title: Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes.
abstract: The engagement of inhibitory receptors specific for major histocompatibility complex class I (MHC-I) molecules educates natural killer (NK) cells, meaning the improvement of the response of activation receptors to subsequent stimulation. It is not known whether inhibitory MHC-I receptors educate only NK cells or whether they improve the responsiveness of all cell types, which express them. To address this issue, we analyzed the expression of inhibitory MHC-I receptors on intestinal intraepithelial lymphocytes (iIELs) and show that T-cell receptor (TCR)-αβ CD8αα iIELs express multiple inhibitory receptors specific for MHC-I molecules, including CD94/NKG2A, Ly49A, and Ly49G2. However, the presence of MHC-I ligand for these receptors did not improve the response of iIELs to activation via the TCR. The absence of iIEL education by MHC-I receptors was not related to a lack of inhibitory function of these receptors in iIELs and a failure of these receptors to couple to the TCR. Thus, unlike NK cells, iIELs do not undergo an MHC-I-guided education process. These data suggest that education is an NK cell-specific function of inhibitory MHC-I receptors.
authors: Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium.
authors: Sylvie
authors: S
authors: Taveirne
authors: Jessica
authors: J
authors: Filtjens
authors: Els
authors: E
authors: Van Ammel
authors: Veerle
authors: V
authors: De Colvenaer
authors: Tessa
authors: T
authors: Kerre
authors: Tom
authors: T
authors: Taghon
authors: Bart
authors: B
authors: Vandekerckhove
authors: Jean
authors: J
authors: Plum
authors: Werner
authors: W
authors: Held
authors: Georges
authors: G
authors: Leclercq