title: New substituted isocoumarins and Dihydroisocoumarins and their cytotoxic activities.
abstract: New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocoumarin was prepared on an alternative pathway. Some of the new compounds showed moderate cytotoxic activities against a human leukemia cell line (HL 60).
authors: Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5-13, D-81377 Munich, Germany.
authors: Veronika
authors: V
authors: Hampl
authors: Isolde
authors: I
authors: Wetzel
authors: Franz
authors: F
authors: Bracher
authors: Jürgen
authors: J
authors: Krauss
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