title: Oxidative DNA damage in early pregnancy and risk of gestational diabetes mellitus: A pilot study.
abstract: OBJECTIVE
  To examine the association of maternal early pregnancy oxidative stress with risk of gestational diabetes mellitus (GDM).
  
  
  METHODS
  A pilot prospective, nested case-control study was conducted. Study participants were recruited before 20weeks gestation. Maternal urinary 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of systemic oxidative DNA damage and repair, was measured using competitive immunoassays. Logistic regression was used to calculate odds ratio (OR) and 95% confidence intervals (95%CI).
  
  
  RESULTS
  Elevations in early pregnancy urinary 8-OHdG concentrations were associated with increased GDM risk. After adjusting for confounders, the OR for extreme quartiles (≥8.01 vs. <4.23ng/mg creatinine) of 8-OHdG was 3.79 (95%CI 1.03-14.00). The risk for GDM was highest for overweight women with urine 8-OHdG concentrations ≥8.01ng/mg creatinine (OR=5.36, 95%CI 1.33-21.55) when compared with lean women who had 8-OHdG concentrations <8.01ng/mg creatinine.
  
  
  CONCLUSIONS
  Elevated urine 8-OHdG concentrations in early pregnancy appear to be associated with increased GDM risk.
authors: Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington, USA. Chun-fang.Qiu@Swedish.org
authors: Chunfang
authors: C
authors: Qiu
authors: Karin
authors: K
authors: Hevner
authors: Dejene
authors: D
authors: Abetew
authors: Daniel A
authors: DA
authors: Enquobahrie
authors: Michelle A
authors: MA
authors: Williams
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