title: Cord blood-derived hematopoietic stem/progenitor cells: current challenges in engraftment, infection, and ex vivo expansion.
abstract: Umbilical cord blood has served as an alternative to bone marrow for hematopoietic transplantation since the late 1980s. Numerous clinical studies have proven the efficacy of umbilical cord blood. Moreover, the possible immaturity of cells in umbilical cord blood gives more options to recipients with HLA mismatch and allows for the use of umbilical cord blood from unrelated donors. However, morbidity and mortality rates associated with hematopoietic malignancies still remain relatively high, even after cord blood transplantation. Infections and relapse are the major causes of death after cord blood transplantation in patients with hematopoietic diseases. Recently, new strategies have been introduced to improve these major problems. Establishing better protocols for simple isolation of primitive cells and ex vivo expansion will also be very important. In this short review, we discuss several recent promising findings related to the technical improvement of cord blood transplantation.
authors: Department of Surgery, Shriners Hospitals for Children, University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA.
authors: Katsuhiro
authors: K
authors: Kita
authors: Jong O
authors: JO
authors: Lee
authors: Celeste C
authors: CC
authors: Finnerty
authors: David N
authors: DN
authors: Herndon
references: Blood. 1994 Apr 15;83(8):2057-62
references: 7512837
references: J Exp Med. 1993 May 1;177(5):1331-42
references: 7683034
references: J Biotechnol. 2006 Jul 25;124(3):592-601
references: 16513201
references: Lancet. 1995 Jul 22;346(8969):214-9
references: 7616801
references: J Hematother. 1996 Dec;5(6):655-62
references: 9117254
references: Am J Hematol. 1997 Nov;56(3):161-7
references: 9371528
references: Eur J Haematol. 2003 Nov;71(5):341-50
references: 14667197
references: Blood. 2000 Nov 15;96(10):3414-21
references: 11071636
references: Blood. 1992 Jun 15;79(12):3159-67
references: 1375842
references: J Biol Chem. 2001 Aug 10;276(32):29839-45
references: 11390394
references: Blood. 2000 Oct 15;96(8):2717-22
references: 11023503
references: Blood. 1995 Oct 15;86(8):3247-56
references: 7579422
references: Science. 1988 Jul 1;241(4861):58-62
references: 2898810
references: Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4040-4
references: 8633013
references: Blood. 2001 Oct 15;98(8):2332-8
references: 11588027
references: Blood. 2010 Apr 1;115(13):2695-703
references: 20110422
references: Exp Hematol. 2003 Jun;31(6):535-44
references: 12829030
references: Blood. 1999 Dec 1;94(11):3928-40
references: 10572110
references: Blood. 1998 Jan 1;91(1):100-10
references: 9414273
references: Exp Hematol. 1980 Nov;8(10):1202-7
references: 6164560
references: Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9118-23
references: 10430905
references: N Engl J Med. 1998 Nov 26;339(22):1565-77
references: 9828244
references: Lancet. 1997 Sep 13;350(9080):767-71
references: 9297996
references: Nat Med. 1997 Dec;3(12):1337-45
references: 9396603
references: Br J Haematol. 2001 Feb;112(2):397-404
references: 11167838
references: Blood. 2000 Jun 1;95(11):3489-97
references: 10828034
references: Stem Cells. 1998;16 Suppl 2:243-8
references: 11012196
references: Blood. 2000 Sep 1;96(5):1748-55
references: 10961873
references: Blood. 2005 Oct 15;106(8):2693-9
references: 15976178
references: Blood. 1997 Dec 1;90(11):4363-8
references: 9373247
references: J Immunol. 2002 Dec 15;169(12):7000-8
references: 12471135
references: Exp Hematol. 1994 Apr;22(4):388-92
references: 7512047
references: Biotechnology (N Y). 1993 Mar;11(3):368-72
references: 7763438
references: Annu Rev Biomed Eng. 1999;1:129-52
references: 11701485
references: Science. 1996 Jul 12;273(5272):242-5
references: 8662508
references: Nat Med. 2010 Feb;16(2):232-6
references: 20081862
references: Stem Cells. 2001;19(4):313-20
references: 11463951
references: Science. 1999 Feb 5;283(5403):845-8
references: 9933168
references: J Clin Invest. 2002 Oct;110(8):1165-74
references: 12393852
references: Biotechnol Bioeng. 2009 Nov 1;104(4):832-40
references: 19591208
references: N Engl J Med. 1996 Jul 18;335(3):157-66
references: 8657213
references: Blood. 1993 Mar 15;81(6):1479-88
references: 7680919
references: Acta Paediatr Scand. 1978 Jul;67(4):413-6
references: 676726
references: J Clin Invest. 1982 Dec;70(6):1324-8
references: 7174797
references: Blood. 2001 May 15;97(10):2957-61
references: 11342417
references: Exp Hematol. 1981 Aug;9(7):716-22
references: 7318975
references: Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2859-63
references: 7535932
references: Leuk Lymphoma. 2001 Jan;40(3-4):221-34
references: 11426544
references: Cell. 2009 Apr 17;137(2):369-79
references: 19379700
references: Blood. 1996 Jan 1;87(1):1-13
references: 8547630
references: Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10006-10
references: 1438190
references: N Engl J Med. 1989 Oct 26;321(17):1174-8
references: 2571931
references: Stem Cells. 1999;17(5):286-94
references: 10527463
references: Science. 2010 Sep 10;329(5997):1345-8
references: 20688981
references: J Exp Med. 1996 Oct 1;184(4):1357-64
references: 8879208
references: Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9836-41
references: 9275212
references: J Hematother. 1997 Apr;6(2):145-50
references: 9131444
references: Methods Enzymol. 2006;419:439-73
references: 17141066
references: Leukemia. 1998 May;12(5):728-34
references: 9593271
references: Blood. 1996 Jul 15;88(2):487-91
references: 8695796
references: Br J Haematol. 1998 Jun;101(3):425-35
references: 9633882
references: Science. 2004 Aug 13;305(5686):1000-3
references: 15310902
references: Stem Cells. 1993 Jul;11 Suppl 2:105-12
references: 7691315
references: Bone Marrow Transplant. 2002 Dec;30(12):937-43
references: 12476288
references: Leukemia. 1997 Apr;11(4):524-30
references: 9096693
references: J Immunol. 1998 Dec 1;161(11):5909-17
references: 9834071
references: Stem Cells Dev. 2007 Jun;16(3):347-54
references: 17610364
references: Blood. 1990 May 15;75(10):1947-50
references: 2337669
references: Blood. 1995 Apr 1;85(7):1751-61
references: 7535587
references: N Engl J Med. 1993 Mar 4;328(9):593-602
references: 8429851
references: Transfus Apher Sci. 2004 Apr;30(2):153-6
references: 15062755
references: J Exp Med. 1992 Jun 1;175(6):1443-7
references: 1375260
references: J Exp Med. 1991 Jul 1;174(1):63-71
references: 1711568
references: N Engl J Med. 2001 Jun 14;344(24):1815-22
references: 11407342
references: Blood. 1996 Aug 1;88(3):795-802
references: 8704232
references: N Engl J Med. 1957 Sep 12;257(11):491-6
references: 13464965
references: N Engl J Med. 1997 Aug 7;337(6):373-81
references: 9241126
references: Blood. 1995 Nov 1;86(9):3413-20
references: 7579445