title: Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)--a potential mechanism for the anti-cancer effects of ibuprofen.
abstract: Metabolic chiral inversion of 2-arylpropanoic acids (2-APAs;'profens'), such as ibuprofen, is important for pharmacological activity. Several 2-APA-CoA esters were good racemisation substrates for human AMACR 1A, suggesting a common chiral inversion pathway for all 2-APAs and an additional mechanism for their anti-cancer properties.
authors: Medicinal Chemistry, Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK. M.D.Lloyd@bath.ac.uk
authors: Timothy J
authors: TJ
authors: Woodman
authors: Pauline J
authors: PJ
authors: Wood
authors: Andrew S
authors: AS
authors: Thompson
authors: Thomas J
authors: TJ
authors: Hutchings
authors: Georgina R
authors: GR
authors: Steel
authors: Ping
authors: P
authors: Jiao
authors: Michael D
authors: MD
authors: Threadgill
authors: Matthew D
authors: MD
authors: Lloyd