title: Risk of canine cranial cruciate ligament rupture is not associated with the major histocompatibility complex.
abstract: OBJECTIVE
  To investigate the association of the major histocompatability (MHC) class II allele haplotype frequencies with the diagnosis of cranial cruciate ligament (CCL) rupture in two breeds of dog.
  
  
  METHODS
  DNA samples from populations of Labrador Retrievers and Golden Retrievers with CCL rupture and general populations of the same breeds were characterised for three DLA class II loci (DRB1*, DQA1* and DQB1*) alleles using sequence-based typing or reference strand-mediated conformation analysis.
  
  
  RESULTS
  Although distinct differences in haplotype types, frequencies and homozygozity were observed between the two breeds, no disease specific association could be identified for the development of the CCL rupture within either population.
  
  
  CONCLUSIONS
  The risk for developing CCL rupture was not associated with DLA haplotype group(s) in Labrador Retrievers or Golden Retrievers, thus the hypothesis that there is an autoimmune basis to CCL rupture was not supported.
authors: Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, Scotland. dylan.clements@ed.ac.uk
authors: D N
authors: DN
authors: Clements
authors: L J
authors: LJ
authors: Kennedy
authors: A D
authors: AD
authors: Short
authors: A
authors: A
authors: Barnes
authors: J
authors: J
authors: Ferguson
authors: W E R
authors: WE
authors: Ollier