title: Hyperbaric oxygen therapy for painful bladder syndrome/interstitial cystitis resistant to conventional treatments: long-term results of a case series in Japan.
abstract: BACKGROUND
  There is no confirmed strategy for treating painful bladder syndrome/interstitial cystitis (PBS/IC) with unclear etiology. Therefore, a pilot study was carried out to evaluate the efficacy and safety of hyperbaric oxygen (HBO) therapy in treatment-resistant PBS/IC patients.
  
  
  METHODS
  HBO treatment (2.0 ATA for 60 minutes/day × 5 days/week for 2 or 4 weeks) was performed on 11 patients with severe symptoms that had not been improved by previous therapy regimens between December 2004 and July 2009.
  
  
  RESULTS
  Seven of the 11 patients demonstrated persistent improvement in symptoms during the 12 months after HBO treatment. These responders demonstrated a decrease in the pelvic pain scale and urgency scale from 7.7 ± 1.0 and, 6.6 ± 0.9 to 3.4 ± 2.5 and 4.3 ± 2.4 after 12 months, respectively (p < 0.05). The total score of the interstitial cystitis symptom index and 24-hour urinary frequency demonstrated a significant sustained decrease from the baseline. Two responders, who received an additional course of HBO 12 and 13 months after initial treatment, respectively, did not suffer impairment for more than two years. There was one case of transient eustachian tube dysfunction and three cases of reversible exudative otitis media as a consequence of HBO treatment.
  
  
  CONCLUSIONS
  HBO is a potent treatment for PBS/IC patients resistant to conventional therapy. It was well tolerated and provided maintained amelioration of pain, urgency and urinary frequency for at least 12 months.
authors: Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan. tomoaki826@kde.biglobe.ne.jp
authors: Tomoaki
authors: T
authors: Tanaka
authors: Yujiro
authors: Y
authors: Nitta
authors: Kazuya
authors: K
authors: Morimoto
authors: Noriaki
authors: N
authors: Nishikawa
authors: Chikako
authors: C
authors: Nishihara
authors: Satoshi
authors: S
authors: Tamada
authors: Hidenori
authors: H
authors: Kawashima
authors: Tatsuya
authors: T
authors: Nakatani
references: Int J Urol. 2007 Jun;14(6):563-5
references: 17593107
references: Acta Physiol Scand Suppl. 1969;334:1-72
references: 5383545
references: Urol Clin North Am. 1994 Feb;21(1):7-20
references: 8284848
references: J Urol. 1999 May;161(5):1596-7
references: 10210424
references: J Urol. 1994 Jun;151(6):1514-7
references: 8189559
references: J Urol. 1993 Aug;150(2 Pt 1):332-4
references: 8326555
references: Eur Urol. 2004 Jul;46(1):108-13
references: 15183555
references: J Urol. 2002 Jun;167(6):2470-2
references: 11992059
references: Am Surg. 1986 Dec;52(12):659-62
references: 2431639
references: Int Urogynecol J Pelvic Floor Dysfunct. 2000;11(1):23-32
references: 10738931
references: Scand J Urol Nephrol. 2005;39(1):73-7
references: 15764276
references: J Urol. 1999 Aug;162(2):330-4
references: 10411032
references: Eur Urol. 2004 Dec;46(6):681-9
references: 15548433
references: Eur Urol. 2006 Apr;49(4):704-9
references: 16417964
references: J Urol. 2006 Oct;176(4 Pt 1):1442-6
references: 16952654
references: BJU Int. 2002 Apr;89(6):637-8
references: 11942986
references: J Urol. 1993 Jun;149(6):1617-21
references: 8501819
references: J Urol. 1999 Sep;162(3 Pt 1):647-54
references: 10458334
references: J Urol. 1993 Apr;149(4):890-2
references: 8455269
references: Eur Urol. 2001 Aug;40(2):111-23
references: 11528186
references: J Urol. 2008 Mar;179(3):1031-4
references: 18206941
references: Am J Physiol Renal Physiol. 2000 Apr;278(4):F540-53
references: 10751214