title: Bisindole alkaloids and secoiridoids from Alstonia macrophylla Wall. ex G. Don.
abstract: The ethanolic extract from stems of a Thai medicinal plant, Alstonia macrophylla Wall. ex G. Don (Apocynaceae) showed a significant inhibitory effect on acetylcholinesterase (AChE) determined by using Ellman assay. Four compounds i.e., a bisindole alkaloid, macralstonine (1), a new bisindole alkaloid, thungfaine (2), a secoiridoid glycoside, sweroside (3) and a new secoiridoid glycoside, naresuanoside (4) were isolated. Compound 4 showed moderate AChE and butyrylcholinesterase (BChE) inhibitory effects. Interestingly, compound 4 inhibited cell growth on human androgen-sensitive prostate cancer cell line (LNCaP) but no effect on viability of human foreskin fibroblast cells (HF).
authors: Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.
authors: Kanokwan
authors: K
authors: Changwichit
authors: Nantaka
authors: N
authors: Khorana
authors: Khanit
authors: K
authors: Suwanborirux
authors: Neti
authors: N
authors: Waranuch
authors: Nanteetip
authors: N
authors: Limpeanchob
authors: Wutichai
authors: W
authors: Wisuitiprot
authors: Nungruthai
authors: N
authors: Suphrom
authors: Kornkanok
authors: K
authors: Ingkaninan