title: Lipid lowering by hydroalcoholic extracts of Amaranthus caudatus L. induces regression of rabbits atherosclerotic lesions.
abstract: BACKGROUND
  The antihypercholesterolemic and antiatherogenic effect of hydroalcoholic extracts of Amaranthus caudatus L (A. caudatus). on regression of atherosclerosis in experimental rabbits maintained on a high cholesterol diet.
  
  
  METHODS
  Twenty five rabbits were randomly divided into five groups of five each and treated 75 days as follows: Group I: normal diet(ND), Group II: Hypercholesterolemic diet (HCD) for 45 days; Group III: Hypercholesterolemic diet (HCD) for 75 days, Group IV and V: HCD for 45 days and then normal diet and normal diet + A. caudatus(150 mg·kg day) respectively for an additional 30 days(regression period). Blood samples were collected before (0 time) and after 45 days and 75 days of experimental diets for measurement of biochemical factors. The aortas were removed at the end of the study for assessment of atherosclerotic plaques.
  
  
  RESULTS
  In regression period dietary use of A. caudatus in group V significantly decreased total cholesterol, LDL-cholesterol, malondialdehyde, C-reactive protein while apolipoproteinA and HDL-cholesterol was significantly increased compared to group IV. The atherosclerotic area was significantly decreased in group V. Whereas, the animals that in regression period received only normal diet showed no regression but rather progression of atherosclerosis.
  
  
  CONCLUSIONS
  These results thus suggest that hydroalcoholic extracts of A. caudatus can reduce risk factors and cause regression of fatty lesions in aorta.
authors: Department of Biology, Faculty of Sciences, Isfahan University, Isfahan, Iran. kabiri_s97@yahoo.com
authors: Najmeh
authors: N
authors: Kabiri
authors: Sedigheh
authors: S
authors: Asgary
authors: Mahbubeh
authors: M
authors: Setorki
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