title: Circular polarization intrinsic optical signal recording of stimulus-evoked neural activity.
abstract: Linear polarization intrinsic optical signal (LP-IOS) measurement can provide sensitive detection of neural activities in stimulus-activated neural tissues. However, the LP-IOS magnitude and signal-to-noise ratio (SNR) are highly correlated with the nerve orientation relative to the polarization plane of the incident light. Because of the complexity of orientation dependency, LP-IOS optimization and outcome interpretation are time consuming and complicated. In this study, we demonstrate the feasibility of circular polarization intrinsic optical signal (CP-IOS) measurement. Our theoretical modeling and experimental investigation indicate that CP-IOS magnitude and SNR are independent from the nerve orientation. Therefore, CP-IOS promises a practical method for polarization IOS imaging of complex neural systems.
authors: Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
authors: Rong-Wen
authors: RW
authors: Lu
authors: Qiu-Xiang
authors: QX
authors: Zhang
authors: Xin-Cheng
authors: XC
authors: Yao
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