title: Alteration of GTP-binding proteins in ovarian tumors (Review).
abstract: GTP-binding proteins (G proteins) couple cell surface receptors to generation of a variety of intracellular second messengers. The mutant G protein products may be responsible for trapping the protein in its active and subsequently the abnormal growth of malignant cells and dysfunction. We present recent examples of G protein gene mutations in ovarian tumors and illustrate how such defects might lead to abnormal tumor proliferation.
authors: A
authors: A
authors: Imai
authors: S
authors: S
authors: Horibe
authors: H
authors: H
authors: Takagi
authors: T
authors: T
authors: Fuseya
authors: T
authors: T
authors: Tamaya