title: Cross-sectional study of bone metabolism with nutrition in adult classical phenylketonuric patients diagnosed by neonatal screening.
abstract: The mechanism underlying the development of osteopenia or osteoporosis in longstanding phenylketonuria (PKU) remains to be clarified. We investigated the details of bone metabolism in 21 female and 13 male classical PKU patients aged 20-35 years. Vitamin D (VD), parathyroid hormone (PTH), bone turnover markers, and daily nutrient intake were examined. The patients had lower daily energy and protein intake than did the age-matched controls (22 women, 14 men), but their respective fat, VD, and calcium intake did not differ. Serum 1,25-dihydroxy VD and 25-hydroxy VD levels in female and male patient groups were significantly higher and lower than those in respective control groups (females, P < 0.001; males, P < 0.05 and P < 0.01, respectively). Serum intact PTH levels were significantly higher in the female patient group (P < 0.05). Urinary calcium levels in the patient groups were significantly higher than those of the control subjects (females, P < 0.001; males, P < 0.05). Bone resorption markers were significantly higher in patients than in controls, although bone formation markers were not different. Patient serum levels of osteoprotegerin-inhibiting bone resorption were significantly lower (females, P < 0.001; males, P < 0.01). None of the bone parameters correlated significantly with serum phenylalanine or nutrient intake. PKU patients exhibited lower VD status and more rapid bone resorption despite normal calcium-VD intakes.
authors: Department of Pediatrics, Takarazuka City Hospital, 4-5-1 Kohama Cho, Takarazuka 665-0827, Japan. nagasa-hirono@k2.dion.ne.jp
authors: Hironori
authors: H
authors: Nagasaka
authors: Hirokazu
authors: H
authors: Tsukahara
authors: Tomozumi
authors: T
authors: Takatani
authors: Yoshitami
authors: Y
authors: Sanayama
authors: Masaki
authors: M
authors: Takayanagi
authors: Toshihiro
authors: T
authors: Ohura
authors: Osamu
authors: O
authors: Sakamoto
authors: Tetsuya
authors: T
authors: Ito
authors: Mika
authors: M
authors: Wada
authors: Makoto
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authors: Yoshino
authors: Akira
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authors: Ohtake
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authors: Yorifuji
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authors: Miida
authors: Hiroki
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authors: Fujimoto
authors: Hiroshi
authors: H
authors: Mochizuki
authors: Toshikazu
authors: T
authors: Hattori
authors: Yoshiyuki
authors: Y
authors: Okano
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