title: Expression of secreted mucins (MUC2, MUC5AC, MUC5B, and MUC6) and membrane-bound mucin (MUC4) in the lungs of pigs experimentally infected with Actinobacillus pleuropneumoniae.
abstract: The expression patterns of different secreted (MUC2, MUC5AC, MUC5B, and MUC6) and membrane-bound (MUC4) mucins were determined immunohistochemically in the lungs of pigs experimentally infected with Actinobacillus pleuropneumoniae. Forty-seven-week-old colostrum-deprived pigs were randomly allocated to infected (n=20) or control groups (n=20). Five infected and uninfected pigs were euthanized at 0, 6, 12, and 48 h post-inoculation (hpi). In the infected pigs, the expression of both types of mucins, which were invariably observed, was associated with bronchiolar and respiratory bronchiolar lesions. Strong positive mucin signals were seen on the surface of bronchiolar and respiratory bronchiolar epithelium with neutrophil infiltration. The mean mucin-positive area peaked at 6 hpi and decreased significantly to control levels by 48 hpi on the surface of the bronchiolar and respiratory bronchiolar epithelium. Further studies are needed to establish the functional relationship between mucin expression and the host defense mechanism against A. pleuropneumoniae in the lungs of infected pigs.
authors: Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 599 Gwanak-ro, Gwanak-Gu, 151-742 Seoul, Republic of Korea.
authors: Chung Hyun
authors: CH
authors: Kim
authors: Yeonsu
authors: Y
authors: Oh
authors: Kiwon
authors: K
authors: Han
authors: Hwi Won
authors: HW
authors: Seo
authors: Duyeol
authors: D
authors: Kim
authors: Ikjae
authors: I
authors: Kang
authors: Changhoon
authors: C
authors: Park
authors: Ki Young
authors: KY
authors: Jang
authors: Sung-Hoon
authors: SH
authors: Kim
authors: Chanhee
authors: C
authors: Chae