title: Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation.
abstract: Four platinum(II) complexes of general formula [PtCl(η(1)-C(9)H(7))L(2)] [where L(2) is 1,2-bis(diphenylphosphino)ethane (dppe) 1 or cycloocta-1,5-diene (cod) 3] and [PtCl(2)L(2)] (where L(2) is dppe 2 or cod 4) were studied. Inhibition growth assays on human tumor cell lines evidenced for 1 and 3 an antiproliferative effect and, interestingly, the cytotoxic effect exerted by 1 is similar to that of cisplatin. Electrochemical and NMR measurements allowed us to determine the structural and redox properties. Investigation of the mechanism of action responsible for the cytotoxicity demonstrated a weak capacity of interacting with DNA. Some experiments performed on rat liver mitochondria indicate that 1 acts as an inducer of the mitochondrial permeability transition, thus leading to the release of proapoptotic factors, such as cytochrome c and apoptosis-inducing factor.
authors: Department of Pharmaceutical Sciences, University of Padova, Padua, Italy.
authors: Lisa
authors: L
authors: Dalla Via
authors: Saverio
authors: S
authors: Santi
authors: Vito
authors: V
authors: Di Noto
authors: Alfonso
authors: A
authors: Venzo
authors: Enzo
authors: E
authors: Agostinelli
authors: Annarica
authors: A
authors: Calcabrini
authors: Maria
authors: M
authors: Condello
authors: Antonio
authors: A
authors: Toninello
references: Cancer Res. 1986 Oct;46(10):5054-60
references: 3756863
references: J Mol Biol. 1962 Jul;5:109-18
references: 14470099
references: Cancer Res. 1986 Nov;46(11):5486-93
references: 3756897
references: Anticancer Res. 1997 Sep-Oct;17(5A):3239-42
references: 9413154
references: Curr Med Chem. 2006;13(11):1337-57
references: 16712474
references: Biophys Chem. 1990 Apr;35(2-3):129-41
references: 2204440
references: Cytometry. 2001 Oct 1;45(2):151-7
references: 11590627
references: J Med Chem. 2005 Feb 24;48(4):977-85
references: 15715467
references: J Med Chem. 2007 Mar 8;50(5):1019-27
references: 17286392
references: Chembiochem. 2003 Aug 4;4(8):754-61
references: 12898627
references: Chembiochem. 2003 Jan 3;4(1):62-8
references: 12512077
references: Chembiochem. 2001 Jan 8;2(1):20-9
references: 11828422
references: J Med Chem. 1990 May;33(5):1386-92
references: 2329559
references: Chemistry. 1997 Feb;3(2):279-85
references: 24022959
references: J Biol Chem. 1949 Feb;177(2):751-66
references: 18110453
references: Chem Biol. 2004 Apr;11(4):557-64
references: 15123250
references: Cytometry. 1998 Jan 1;31(1):1-9
references: 9450519
references: J Am Chem Soc. 2001 Oct 31;123(43):10595-606
references: 11673991
references: J Photochem Photobiol B. 2005 Apr 4;79(1):59-65
references: 15792880
references: Free Radic Biol Med. 1998 Jun;24(9):1455-61
references: 9641263
references: Physiol Rev. 2007 Jan;87(1):99-163
references: 17237344
references: Bioorg Med Chem. 2009 Jan 1;17(1):326-36
references: 19022678
references: Biochem J. 1990 May 15;268(1):153-60
references: 2160810
references: Anticancer Res. 1999 Jan-Feb;19(1A):157-61
references: 10226537
references: Anticancer Res. 1996 Nov-Dec;16(6B):3423-8
references: 9042201
references: Biochem J. 2002 Oct 15;367(Pt 2):541-8
references: 12149099
references: Nat Rev Drug Discov. 2005 Apr;4(4):307-20
references: 15789122
references: Chem Rev. 1999 Sep 8;99(9):2467-98
references: 11749487
references: Chem Rev. 2008 Jul;108(7):2300-47
references: 18605756
references: Anal Biochem. 1969 Mar;27(3):502-22
references: 4388022
references: J Biol Chem. 1988 Aug 15;263(23):11203-10
references: 2457018