title: Cobalt-catalyzed coupling of alkyl Grignard reagent with benzamide and 2-phenylpyridine derivatives through directed C-H bond activation under air.
abstract: Aromatic carboxamides and 2-phenylpyridine derivatives can be ortho-alkylated with Grignard reagents in the presence of a cobalt catalyst and DMPU as a ligand. The reaction proceeds smoothly at room temperature, using air as the sole oxidant. The dialkylated product is selectively obtained when N-methylcarboxamide is employed as a substrate, whereas N-phenyl- or N-isopropylcarboxamide preferentially gives the monoalkylated product.
authors: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Tokyo 113-0033, Japan.
authors: Quan
authors: Q
authors: Chen
authors: Laurean
authors: L
authors: Ilies
authors: Naohiko
authors: N
authors: Yoshikai
authors: Eiichi
authors: E
authors: Nakamura