title: [Structure and function of incretin receptor].
abstract: G protein-coupled receptor (GPCR) is integral membrane protein with seven alfa-helices and most diverse families of protein in mammals. It is located on cell membrane and activated by binding neurotransmit proteins and hormones. It has critical role of functional regulation in central nerve system and peripheral organs. Recently, many orphan GPCRs have been identified from the data of genomic sequence in human genomic project. GIP receptor and GLP-1 receptor belong to glucagon receptor subfamily of class B and are widely expressed in many organs. GIP receptor is expressed in intestine, adipose tissue, brain, adrenal gland, and bone, while GLP-1 receptor is expressed in intestine, CNS, lung, kidney and heart. GIP and GLP-1 have not only pancreatic effect, such as potentiation of insulin secretion but also many extrapancreatic effects.
authors: Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University.
authors: Norio
authors: N
authors: Harada