title: A large population genetic study of 15 autosomal short tandem repeat loci for establishment of Korean DNA profile database.
abstract: Genotyping of highly polymorphic short tandem repeat (STR) markers is widely used for the genetic identification of individuals in forensic DNA analyses and in paternity disputes. The National DNA Profile Databank recently established by the DNA Identification Act in Korea contains the computerized STR DNA profiles of individuals convicted of crimes. For the establishment of a large autosomal STR loci population database, 1805 samples were obtained at random from Korean individuals and 15 autosomal STR markers were analyzed using the AmpFlSTR Identifiler PCR Amplification kit. For the 15 autosomal STR markers, no deviations from the Hardy-Weinberg equilibrium were observed. The most informative locus in our data set was the D2S1338 with a discrimination power of 0.9699. The combined matching probability was 1.521 × 10(-17). This large STR profile dataset including atypical alleles will be important for the establishment of the Korean DNA database and for forensic applications.
authors: Department of Forensic Medicine, Central District Office, National Forensic Service, Daejeon, 305-348, Korea.
authors: Seong Yeon
authors: SY
authors: Yoo
authors: Nam Soo
authors: NS
authors: Cho
authors: Myung Jin
authors: MJ
authors: Park
authors: Ki Min
authors: KM
authors: Seong
authors: Jung Ho
authors: JH
authors: Hwang
authors: Seok Bean
authors: SB
authors: Song
authors: Myun Soo
authors: MS
authors: Han
authors: Won Tae
authors: WT
authors: Lee
authors: Ki Wha
authors: KW
authors: Chung
references: Leg Med (Tokyo). 2006 Jan;8(1):55-7
references: 16213775
references: Int J Legal Med. 2000;114(1-2):41-4
references: 11197626
references: Forensic Sci Int Genet. 2009 Sep;3(4):e117-8
references: 19647695
references: Forensic Sci Int Genet. 2008 Sep;2(4):e71-2
references: 19083833
references: J Forensic Sci. 2004 Nov;49(6):1207-14
references: 15568691
references: J Forensic Sci. 1999 Nov;44(6):1277-86
references: 10582369
references: Mol Cells. 2009 Jan 31;27(1):21-37
references: 19214431
references: Forensic Sci Int. 2003 Sep 9;136(1-3):92-5
references: 12969628
references: Genome Res. 2006 Aug;16(8):949-61
references: 16809666
references: J Forensic Sci. 2001 May;46(3):453-89
references: 11372982
references: Am J Hum Genet. 1994 Jul;55(1):175-89
references: 7912887
references: Forensic Sci Int Genet. 2008 Dec;3(1):e1-3
references: 19083853
references: Mol Ecol Resour. 2010 May;10(3):564-7
references: 21565059
references: J Forensic Sci. 2006 Mar;51(2):253-65
references: 16566758
references: Heredity (Edinb). 1951 Apr;5(1):95-102
references: 14840760
references: Forensic Sci Int. 2000 Sep 11;113(1-3):25-7
references: 10978596
references: Forensic Sci Int Genet. 2008 Mar;2(2):e1-4
references: 19083795
references: Leg Med (Tokyo). 2006 May;8(3):182-3
references: 16515880
references: J Forensic Sci. 2005 May;50(3):710-2
references: 15932114
references: Nucleic Acids Res. 1989 Aug 25;17(16):6463-71
references: 2780284