title: 10-(2-Eth-oxy-1,3-thia-zol-5-yl)-10-hy-droxy-phenanthren-9(10H)-one.
abstract: In the title compound, C(19)H(15)NO(3)S, the dihydro-phenanthrene unit is not planar, its central ring being distorted towards a sofa conformation. The essentially planar thia-zole ring [maximum deviation = 0.005 (1) Å] is inclined at a dihedral angle of 85.29 (5)° with respect to the mean plane formed through the dihydro-phenanthrene unit. In the crystal structure, pairs of inter-molecular C-H⋯O hydrogen bonds link adjacent mol-ecules into inversion dimers. Inter-molecular O-H⋯N hydrogen bonds further inter-connect these dimers into chains along the a axis. The crystal structure is further stabilized by weak inter-molecular C-H⋯π inter-actions involving the thia-zole ring.
authors: Hoong-Kun
authors: HK
authors: Fun
authors: Jia Hao
authors: JH
authors: Goh
authors: Yang
authors: Y
authors: Liu
authors: Yan
authors: Y
authors: Zhang
references: Free Radic Biol Med. 2003 Apr 15;34(8):1060-9
references: 12684091
references: Org Lett. 2006 Apr 13;8(8):1625-8
references: 16597126
references: J Antibiot (Tokyo). 1995 Oct;48(10):1066-72
references: 7490208
references: J Nat Prod. 2001 Oct;64(10):1354-6
references: 11678667
references: Free Radic Biol Med. 1998 Oct;25(6):635-44
references: 9801062
references: Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55
references: 19171970
references: Org Lett. 2004 Dec 23;6(26):4893-5
references: 15606093
references: J Antibiot (Tokyo). 1995 Oct;48(10):1073-5
references: 7490209
references: Environ Health Perspect. 1983 Jan;47:65-80
references: 6186484
references: Org Lett. 2003 Oct 30;5(22):4163-5
references: 14572275
references: Acta Crystallogr C. 2003 Jun;59(Pt 6):o305-7
references: 12794346
references: J Org Chem. 2001 Dec 14;66(25):8463-9
references: 11735526
references: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references: 18156677
references: Org Biomol Chem. 2010 Jul 21;8(14):3259-66
references: 20502779
references: J Org Chem. 2010 Jan 1;75(1):152-61
references: 19954177