title: Induction of myeloma-specific cytotoxic T lymphocytes responses by natural killer cells stimulated-dendritic cells in patients with multiple myeloma.
abstract: The interaction between dendritic cells (DCs) and natural killer (NK) cells plays a key role in inducing DC maturation for subsequent T-cell priming. We investigated to generate potent DCs by stimulated with NK cells to induce myeloma-specific cytotoxic T lymphocytes (CTLs). NK cells-stimulated-DCs exhibited high expression of costimulatory molecules and high production of IL-12p70. These DCs induce high potency of Th1 polarization and exhibit a high ability to generate myeloma-specific CTLs responses. These results suggest that functionally potent DCs can be generated by stimulation with NK cells and may provide an effective source of DC-based immunotherapy in multiple myeloma.
authors: Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Jeollanamdo, Hwasun, Republic of Korea.
authors: Thanh-Nhan
authors: TN
authors: Nguyen-Pham
authors: Chang-Min
authors: CM
authors: Im
authors: Truc-Anh Thi
authors: TA
authors: Nguyen
authors: Mi-Seon
authors: MS
authors: Lim
authors: Cheol Yi
authors: CY
authors: Hong
authors: Mi-Hyun
authors: MH
authors: Kim
authors: Hyun Ju
authors: HJ
authors: Lee
authors: Youn-Kyung
authors: YK
authors: Lee
authors: Duck
authors: D
authors: Cho
authors: Jae-Sook
authors: JS
authors: Ahn
authors: Deok-Hwan
authors: DH
authors: Yang
authors: Yeo-Kyeoung
authors: YK
authors: Kim
authors: Ik-Joo
authors: IJ
authors: Chung
authors: Hyeoung-Joon
authors: HJ
authors: Kim
authors: Je-Jung
authors: JJ
authors: Lee