title: Immunohistochemical detection of p53 protein and proliferating cell nuclear antigen (pcna) in salivary-gland tumors.
abstract: The expression of p53 protein and PCNA was immunohistochemically examined in 161 cases of salivary gland tumors. The p53 protein was positive in 23.8% (24/101) of malignant salivary gland tumors, while only one case of 60 pleomorphic adenomas was positive. p53 protein was frequently detectable in salivary duct carcinoma (60%), basal cell adenocarcinoma (66.7%), acinic cell carcinoma (53.3%) and undifferentiated carcinoma (50%), but was rarely seen in adenoid cystic carcinoma (17.2%) and mucoepidermoid carcinoma (0%). p53 protein was more frequently detectable in PCNA positive cases than in negative cases (p=0.0074).
authors: YAMAGUCHI UNIV,SCH MED,DEPT ORAL & MAXILLOFACIAL SURG,1144 KOGUSHI,UBE,YAMAGUCHI 755,JAPAN. CHINA MED UNIV,SCH MED,DEPT ORAL & MAXILLOFACIAL SURG,SHENYANG 110002,PEOPLES R CHINA. CHINA MED UNIV,SCH MED,DEPT ORAL PATHOL,SHENYANG 110002,PEOPLES R CHINA. YAMAGUCHI UNIV,SCH MED,DEPT PATHOL 2,UBE,YAMAGUCHI 755,JAPAN. IWATE MED UNIV,SCH MED,DEPT PATHOL 1,MORIOKA,IWATE 020,JAPAN.
authors: S
authors: S
authors: Wen
authors: T
authors: T
authors: Tsuji
authors: X
authors: X
authors: Li
authors: Y
authors: Y
authors: Mimura
authors: K
authors: K
authors: Sasaki
authors: F
authors: F
authors: Shinozaki