title: Spatiotemporal differences in vascular permeability after ischaemic brain damage.
abstract: To study spatiotemporal differences in vascular permeability, we histologically analysed tracer extravasation, neovessels and reactive astrocytes in a mouse ischaemic brain damage model. On day 1 after damage induction, the extravasation was not associated with the distribution of neovessels or reactive astrocytes. On day 7, the extravasation was limited within the infarct region in which neovessels, but not reactive astrocytes, were observed. However, the extravasation was not observed at peri-infarct region in which both neovessels and reactive astrocytes were observed, suggesting that neovessels had high permeability and reactive astrocytes prevented the extravasation from neovessels. Furthermore, the extravasation was denser in the regions near the surface than in those further in the infarct region, suggesting a spatial heterogeneity in neovascular permeability.
authors: Department of Physiology, Kinki University Faculty of Medicine, Ohnohigashi, Osakasayama, Japan.
authors: Masato
authors: M
authors: Yano
authors: Naoyuki
authors: N
authors: Kawao
authors: Yukinori
authors: Y
authors: Tamura
authors: Kiyotaka
authors: K
authors: Okada
authors: Shigeru
authors: S
authors: Ueshima
authors: Nobuo
authors: N
authors: Nagai
authors: Osamu
authors: O
authors: Matsuo