title: A new class of phenazines with activity against a chloroquine resistant Plasmodium falciparum strain and antimicrobial activity.
abstract: New phenazines were synthesized by oxygenation of 1- and 2-naphthol with transition metal peroxo complexes and in situ reaction with 1,2-diamines. The title compounds were evaluated for in vitro antimalarial activity against Plasmodium falciparum and chloroquine-resistant strains. Phenazines 12, 27, and 28 were most prominent in growth inhibition. In vivo protection against cerebral malaria was observed with the phenazines 11, 12, 20, and 27, whereas partial protection was provided by 19.
authors: Department of Chemistry, University of Paderborn, Paderborn, Germany. Hidayat110@gmail.com
authors: Hidayat
authors: H
authors: Hussain
authors: Sabine
authors: S
authors: Specht
authors: Salem R
authors: SR
authors: Sarite
authors: Michael
authors: M
authors: Saeftel
authors: Achim
authors: A
authors: Hoerauf
authors: Barbara
authors: B
authors: Schulz
authors: Karsten
authors: K
authors: Krohn