title: PG F(2α) Receptor: A Promising Therapeutic Target for Cardiovascular Disease.
abstract: Prostaglandins (PGs), a group of key lipid mediators, are involved in numerous physiological and pathological processes including inflammation and cardiovascular homeostasis. Each PG acts on its specific and distinct cell surface G protein-coupled receptors (GPCRs) or peroxisome proliferator-activated receptors (PPARs). Prostaglandin F(2α) receptor (FP) is required for female reproductive function such as luteolysis and parturition. It has recently been implicated in blood pressure regulation, atherosclerosis and other inflammation-related disorders. The emerging role of FP in cardiovascular diseases is highlighted and potential therapeutic translation is discussed in the current review.
authors: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai, China.
authors: Jian
authors: J
authors: Zhang
authors: Yanjun
authors: Y
authors: Gong
authors: Ying
authors: Y
authors: Yu
references: Am J Obstet Gynecol. 2007 Jul;197(1):54.e1-9
references: 17618756
references: Acta Chem Scand. 1992 Jan;46(1):108-10
references: 1318064
references: Cell Signal. 2008 Nov;20(11):2022-9
references: 18703136
references: BMC Pregnancy Childbirth. 2007 Jun 01;7 Suppl 1:S16
references: 17570160
references: Nature. 2008 Feb 21;451(7181):904-13
references: 18288179
references: J Biol Chem. 1999 Dec 10;274(50):35944-9
references: 10585482
references: Clin Rheumatol. 1987 Jun;6(2):170-6
references: 3113811
references: Annu Rev Physiol. 2008;70:357-77
references: 17988207
references: Nature. 1995 Nov 23;378(6555):406-9
references: 7477380
references: J Clin Invest. 2004 Sep;114(6):805-12
references: 15372104
references: Med Res Rev. 2007 Jul;27(4):435-68
references: 17191216
references: J Investig Med. 2009 Aug;57(6):703-8
references: 19240648
references: J Pharm Pharmacol. 2000 Dec;52(12):1529-39
references: 11197083
references: Diabetes Care. 2005 Jun;28(6):1371-5
references: 15920054
references: Nature. 1997 Dec 11;390(6660):622-5
references: 9403693
references: Circ Res. 2009 Feb 27;104(4):506-13
references: 19122175
references: BJOG. 2005 Aug;112(8):1034-42
references: 16045514
references: Invest Ophthalmol Vis Sci. 2001 Feb;42(2):424-8
references: 11157877
references: Surv Ophthalmol. 2002 Aug;47 Suppl 1:S53-64
references: 12204701
references: Science. 2001 Nov 30;294(5548):1871-5
references: 11729303
references: J Clin Invest. 2001 Jun;107(11):1335-7
references: 11390412
references: Am J Physiol. 1996 Dec;271(6 Pt 2):H2197-208
references: 8997275
references: Proc Natl Acad Sci U S A. 2009 May 5;106(18):7548-52
references: 19376970
references: Prostaglandins Leukot Essent Fatty Acids. 2009 Jan;80(1):51-6
references: 19091535
references: Circulation. 2004 Apr 13;109(14):1729-34
references: 15037525
references: Circulation. 1987 May;75(5):956-63
references: 3552297
references: Reprod Biol Endocrinol. 2007 Mar 16;5:10
references: 17367527
references: J Clin Invest. 2001 Jul;108(1):15-23
references: 11435451
references: J Biol Chem. 1997 Oct 24;272(43):27147-54
references: 9341156
references: J Biol Chem. 2005 Oct 14;280(41):35028-37
references: 16096282
references: J Endocrinol. 2008 Apr;197(1):171-9
references: 18372243
references: J Biol Chem. 1985 Jun 10;260(11):7035-41
references: 3858278
references: Prostaglandins. 1997 Aug;54(2):511-30
references: 9380795
references: J Biol Chem. 2007 Jan 5;282(1):329-36
references: 17107953
references: Cell. 1995 Nov 3;83(3):473-82
references: 8521477
references: Int Heart J. 2008 May;49(3):329-42
references: 18612190
references: Am J Obstet Gynecol. 2005 Jul;193(1):256-66
references: 16021088
references: Annu Rev Biochem. 2000;69:145-82
references: 10966456
references: J Pharmacol Exp Ther. 1999 Sep;290(3):1278-84
references: 10454504
references: N Engl J Med. 1999 Jan 14;340(2):115-26
references: 9887164
references: Obstet Gynecol. 1999 Jan;93(1):89-93
references: 9916963
references: Free Radic Res. 2005 Jun;39(6):629-36
references: 16036341
references: Eicosanoids. 1992;5(3-4):163-7
references: 1292526
references: Cytokine. 2007 Jun;38(3):130-6
references: 17644349
references: Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11875-9
references: 9751758
references: Am J Physiol. 1985 May;248(5 Pt 1):G580-6
references: 2986466
references: Nat Med. 2006 Jun;12(6):699-704
references: 16732282
references: Cell. 1995 Nov 3;83(3):483-92
references: 8521478
references: Nat Med. 2009 Dec;15(12):1426-30
references: 19966781
references: J Cardiovasc Pharmacol. 2007 Nov;50(5):470-9
references: 18030055
references: Invest Ophthalmol Vis Sci. 1998 Feb;39(2):315-21
references: 9477988
references: Semin Perinatol. 2002 Dec;26(6):389-97
references: 12537309
references: Circulation. 2005 Apr 19;111(15):1985-91
references: 15837953
references: Proc Natl Acad Sci U S A. 2009 May 12;106(19):7985-90
references: 19416858
references: Eur J Pharmacol. 1985 Oct 8;116(1-2):153-7
references: 3932082
references: J Biol Chem. 1994 Jul 1;269(26):17619-25
references: 8021271
references: J Lipid Res. 2009 Apr;50 Suppl:S423-8
references: 19095631
references: Atherosclerosis. 2005 Jul;181(1):201-7
references: 15939073
references: J Clin Endocrinol Metab. 2004 Feb;89(2):986-93
references: 14764825
references: Nat Med. 2005 May;11(5):562-6
references: 15834430
references: Cardiovasc Res. 1993 Mar;27(3):396-402
references: 8490938
references: Am J Physiol Renal Physiol. 2003 Jun;284(6):F1164-70
references: 12631554
references: Prostaglandins Other Lipid Mediat. 2008 Feb;85(1-2):49-57
references: 18160324
references: J Soc Gynecol Investig. 2005 Oct;12(7):466-78
references: 16202923
references: Ann Rheum Dis. 2001 Jun;60(6):627-31
references: 11350853
references: Scand J Rheumatol. 1977;6(3):151-4
references: 929121
references: J Clin Invest. 2005 Apr;115(4):986-95
references: 15776109
references: J Clin Invest. 2001 Jul;108(1):25-30
references: 11435452
references: J Biol Chem. 1996 Jan 12;271(2):1179-86
references: 8557648
references: Physiol Rev. 1999 Oct;79(4):1193-226
references: 10508233
references: Prostaglandins Leukot Essent Fatty Acids. 2005 Apr;72(4):227-33
references: 15763433
references: J Biol Chem. 1994 Jan 14;269(2):1356-60
references: 8288601
references: J Biol Chem. 1994 Jan 28;269(4):2632-6
references: 8300593
references: Mol Hum Reprod. 2002 Jul;8(7):681-7
references: 12087084
references: Exp Physiol. 2001 Mar;86(2):213-22
references: 11429638
references: J Clin Invest. 2004 Sep;114(6):784-94
references: 15372102
references: Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):77-84
references: 17164135
references: Circ Res. 2009 Jan 30;104(2):228-35
references: 19096033
references: Free Radic Res. 2004 May;38(5):517-25
references: 15293560
references: Cardiovasc Drug Rev. 2006 Spring;24(1):1-10
references: 16939629
references: Science. 1997 Aug 1;277(5326):681-3
references: 9235889