title: Rabies virus as a research tool and viral vaccine vector.
abstract: Until recently, single-stranded negative sense RNA viruses (ssNSVs) were one of only a few important human viral pathogens, which could not be created from cDNA. The inability to manipulate their genomes hindered their detailed genetic analysis. A key paper from Conzelmann's laboratory in 1994 changed this with the publication of a method to recover rabies virus (RABV) from cDNA. This discovery not only dramatically changed the broader field of ssNSV biology but also opened a whole new avenue for studying RABV pathogenicity, developing novel RABV vaccines as well a new generation of RABV-based vaccine vectors, and creating research tools important in neuroscience such as neuronal tracing.
authors: Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors: Emily A
authors: EA
authors: Gomme
authors: Celestine N
authors: CN
authors: Wanjalla
authors: Christoph
authors: C
authors: Wirblich
authors: Matthias J
authors: MJ
authors: Schnell
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