title: Decoding subject-driven cognitive states with whole-brain connectivity patterns.
abstract: Decoding specific cognitive states from brain activity constitutes a major goal of neuroscience. Previous studies of brain-state classification have focused largely on decoding brief, discrete events and have required the timing of these events to be known. To date, methods for decoding more continuous and purely subject-driven cognitive states have not been available. Here, we demonstrate that free-streaming subject-driven cognitive states can be decoded using a novel whole-brain functional connectivity analysis. Ninety functional regions of interest (ROIs) were defined across 14 large-scale resting-state brain networks to generate a 3960 cell matrix reflecting whole-brain connectivity. We trained a classifier to identify specific patterns of whole-brain connectivity as subjects rested quietly, remembered the events of their day, subtracted numbers, or (silently) sang lyrics. In a leave-one-out cross-validation, the classifier identified these 4 cognitive states with 84% accuracy. More critically, the classifier achieved 85% accuracy when identifying these states in a second, independent cohort of subjects. Classification accuracy remained high with imaging runs as short as 30-60 s. At all temporal intervals assessed, the 90 functionally defined ROIs outperformed a set of 112 commonly used structural ROIs in classifying cognitive states. This approach should enable decoding a myriad of subject-driven cognitive states from brief imaging data samples.
authors: Functional Imaging in Neuropsychiatric Disorders (FIND) Lab, Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, CA 94305, USA.
authors: W R
authors: WR
authors: Shirer
authors: S
authors: S
authors: Ryali
authors: E
authors: E
authors: Rykhlevskaia
authors: V
authors: V
authors: Menon
authors: M D
authors: MD
authors: Greicius
references: Neuroimage. 2002 Jan;15(1):273-89
references: 11771995
references: Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):796-802
references: 9448243
references: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
references: 15976020
references: Hum Brain Mapp. 2002 Apr;15(4):247-62
references: 11835612
references: Neuroimage. 2001 Feb;13(2):314-27
references: 11162272
references: Neuroimage. 2005 Dec;28(4):980-95
references: 16275139
references: Neuroimage. 2009 Oct 1;47(4):1448-59
references: 19446646
references: Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2035-40
references: 19188601
references: Magn Reson Med. 2002 Oct;48(4):715-22
references: 12353290
references: Neuroimage. 2003 Jun;19(2 Pt 1):253-60
references: 12814576
references: Neuroimage. 2008 May 15;41(1):45-57
references: 18367410
references: Nat Neurosci. 2005 May;8(5):686-91
references: 15852013
references: AJNR Am J Neuroradiol. 2001 Aug;22(7):1326-33
references: 11498421
references: Magn Reson Med. 2001 Sep;46(3):515-22
references: 11550244
references: Cereb Cortex. 2009 Jan;19(1):72-8
references: 18403396
references: Neuropsychologia. 2006;44(14):2836-45
references: 16879844
references: J Neurosci. 2009 Aug 26;29(34):10573-81
references: 19710310
references: Science. 2005 Dec 23;310(5756):1963-6
references: 16373577
references: J Neurosci. 2007 Feb 28;27(9):2349-56
references: 17329432
references: J Cogn Neurosci. 2000 Nov;12(6):1013-23
references: 11177421
references: Nature. 2008 Mar 20;452(7185):352-5
references: 18322462
references: Cereb Cortex. 2001 Apr;11(4):350-9
references: 11278198
references: Nat Neurosci. 2005 May;8(5):679-85
references: 15852014
references: Curr Biol. 2010 Mar 23;20(6):544-7
references: 20226665
references: Nat Rev Neurosci. 2006 Jul;7(7):523-34
references: 16791142
references: Nat Neurosci. 1998 Nov;1(7):549-50
references: 10196560
references: Science. 1999 May 7;284(5416):970-4
references: 10320379
references: PLoS Biol. 2008 Jul 1;6(7):e159
references: 18597554
references: Neuroimage. 2010 Mar;50(1):81-98
references: 20006716
references: Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13040-5
references: 19620724
references: Curr Biol. 2005 Jul 26;15(14):1301-7
references: 16051174
references: Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53
references: 16945915
references: Magn Reson Med. 1995 Oct;34(4):537-41
references: 8524021
references: Neuroimage. 2000 Oct;12(4):357-65
references: 10988030
references: Science. 2001 Sep 28;293(5539):2425-30
references: 11577229
references: Neuroimage. 2006 Feb 15;29(4):1231-43
references: 16246590
references: Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13
references: 16087444
references: Neuroimage. 2011 May 15;56(2):616-26
references: 20541019
references: Neural Netw. 2000 Oct-Nov;13(8-9):861-70
references: 11156197
references: Hum Brain Mapp. 2009 Dec;30(12):3865-86
references: 19507160
references: Neuroimage. 2010 Apr 15;50(3):970-83
references: 20035887
references: Cereb Cortex. 2006 Oct;16(10):1418-30
references: 16306320
references: AMIA Annu Symp Proc. 2003;:465-9
references: 14728216
references: J Cogn Neurosci. 2011 May;23(5):1198-204
references: 20429856
references: Magn Reson Med. 1998 Mar;39(3):361-8
references: 9498591
references: J Neurosci. 2006 Dec 20;26(51):13338-43
references: 17182784
references: Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8
references: 12506194
references: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4637-42
references: 15070770
references: Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17974-9
references: 19805050
references: PLoS Comput Biol. 2008 Jun 27;4(6):e1000100
references: 18584043
references: Neuroimage. 2005 Nov 15;28(3):663-8
references: 16169252
references: PLoS One. 2008 Mar 19;3(3):e1794
references: 18350136
references: Neuroimage. 1997 Feb;5(2):83-96
references: 9345540
references: Science. 2006 Sep 8;313(5792):1402
references: 16959998