title: Online volume rendering of incrementally accumulated LSCEM images for superficial oral cancer detection.
abstract: Laser scanning confocal endomicroscope (LSCEM) has emerged as an imaging modality which provides non-invasive, in vivo imaging of biological tissue on a microscopic scale. Scientific visualizations for LSCEM datasets captured by current imaging systems require these datasets to be fully acquired and brought to a separate rendering machine. To extend the features and capabilities of this modality, we propose a system which is capable of performing realtime visualization of LSCEM datasets. Using field-programmable gate arrays, our system performs three tasks in parallel: (1) automated control of dataset acquisition; (2) imaging-rendering system synchronization; and (3) realtime volume rendering of dynamic datasets. Through fusion of LSCEM imaging and volume rendering processes, acquired datasets can be visualized in realtime to provide an immediate perception of the image quality and biological conditions of the subject, further assisting in realtime cancer diagnosis. Subsequently, the imaging procedure can be improved for more accurate diagnosis and reduce the need for repeating the process due to unsatisfactory datasets.
authors: Wei Ming Chiew, Feng Lin, Kemao Qian, Hock Soon Seah, School of Computer Engineering, Nanyang Technological University, Singapore 639798, Singapore.
authors: Wei Ming
authors: WM
authors: Chiew
authors: Feng
authors: F
authors: Lin
authors: Kemao
authors: K
authors: Qian
authors: Hock Soon
authors: HS
authors: Seah
references: Appl Opt. 1994 Feb 1;33(4):603-15
references: 20862055
references: J Biomed Opt. 2007 Jan-Feb;12(1):014007
references: 17343482
references: Biol Cell. 2003 Sep;95(6):335-42
references: 14519550
references: Med Image Anal. 2005 Dec;9(6):594-604
references: 15896995
references: IEEE Trans Inf Technol Biomed. 2008 Nov;12(6):800-12
references: 19000961
references: Opt Express. 2009 Jul 6;17(14):11294-308
references: 19582043
references: Annu Int Conf IEEE Eng Med Biol Soc. 2007;2007:6532-5
references: 18003522
references: Radiology. 1986 Sep;160(3):675-81
references: 3737905