title: Regulation of adipocyte differentiation by the zinc finger protein ZNF638.
abstract: Zinc finger proteins constitute the largest family of transcription regulators in eukaryotes. These factors are involved in diverse processes in many tissues, including development and differentiation. We report here the characterization of the zinc finger protein ZNF638 as a novel regulator of adipogenesis. ZNF638 is induced early during adipocyte differentiation. Ectopic expression of ZNF638 increases adipogenesis in vitro, whereas its knockdown inhibits differentiation and decreases the expression of adipocyte-specific genes. ZNF638 physically interacts and transcriptionally cooperates with CCAAT/enhancer-binding protein (C/EBP) β and C/EBPδ. This interaction leads to the expression of peroxisome proliferator-activated receptor γ, which is the key regulator of adipocyte differentiation. In summary, ZNF638 is a novel and early regulator of adipogenesis that works as a transcription cofactor of C/EBPs.
authors: Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors: Sunitha
authors: S
authors: Meruvu
authors: Lynne
authors: L
authors: Hugendubler
authors: Elisabetta
authors: E
authors: Mueller
references: J Cell Biochem. 2002;84(3):556-66
references: 11813260
references: Cell Metab. 2006 Oct;4(4):263-73
references: 17011499
references: Biochem Biophys Res Commun. 1996 Jun 14;223(2):427-33
references: 8670298
references: Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17868-73
references: 17098861
references: Int J Biol Sci. 2009 Oct 01;5(6):622-36
references: 19841733
references: Nature. 2010 Mar 25;464(7288):619-23
references: 20200519
references: Methods Enzymol. 1983;101:582-98
references: 6888276
references: Cell Metab. 2005 Feb;1(2):93-106
references: 16054051
references: Mol Cell Biol. 2005 Jul;25(13):5307-16
references: 15964789
references: Biochem J. 2009 Dec 14;425(1):215-23
references: 19811452
references: Mol Cell. 2000 Aug;6(2):307-16
references: 10983978
references: Mol Cell Biol. 2006 Sep;26(18):6913-22
references: 16943432
references: J Biol Chem. 1996 May 24;271(21):12525-31
references: 8647861
references: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):629-34
references: 11149944