title: Manganese toxicity in a child with iron deficiency and polycythemia.
abstract: A previously healthy 5-year-old girl presented with pica, emotional lability, and marked gait abnormalities. She had concurrent severe iron deficiency and polycythemia. Her magnetic resonance imaging (MRI) scan showed increased signal in the basal ganglia on T1-weighted images consistent with manganese neurotoxicity. Manganism was subsequently confirmed as her blood manganese levels were extremely elevated. Chelation therapy resulted in improvement in her mobility but she continues to have significant gait impairment. An epidemiological investigation identified well water as the potential source of manganese exposure for our patient, but to date, we have been unable to identify the nature of her neurotoxic susceptibility.
authors: Division of Neurology, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. pbrna@dal.ca
authors: Paula
authors: P
authors: Brna
authors: Kevin
authors: K
authors: Gordon
authors: Joseph M
authors: JM
authors: Dooley
authors: Victoria
authors: V
authors: Price