title: Seromucinous hamartoma of the nasal cavity: a report of two cases and review of the literature.
abstract: The sinonasal tract is a complex anatomic site, home to a wide variety of reactive, inflammatory, benign, and malignant lesions. Inflammatory polyps and papillomas are usually easily recognized by pathologists. A poorly understood lesion that has been more clearly defined in recent years is the nasal hamartoma. The epithelial subtypes include seromucinous hamartoma, respiratory epithelial adenomatoid hamartoma, and hybrid lesions. Seromucinous hamartomas have only been recognized and substantially reported over the past few years. They are a diagnostic challenge, needing to be distinguished from low grade adenocarcinomas, and are of interest because most of the basic questions about their pathophysiology remain unanswered. Herein, we present two novel cases of seromucinous hamartoma with features that partly expand the morphologic spectrum of these lesions, discuss the differential diagnosis, and review the literature to compare our findings with previously reported cases with the aim of better understanding this interesting entity.
authors: Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
authors: R A
authors: RA
authors: Khan
authors: R D
authors: RD
authors: Chernock
authors: J S
authors: JS
authors: Lewis
references: J Clin Pathol. 2009 Dec;62(12):1085-95
references: 19946095
references: Am J Rhinol. 2006 Nov-Dec;20(6):586-90
references: 17181098
references: Arch Pathol Lab Med. 2001 Mar;125(3):400-3
references: 11231491
references: Histopathology. 2009 Jan;54(2):205-13
references: 19207945
references: Am J Surg Pathol. 1998 Apr;22(4):425-33
references: 9537469
references: Laryngoscope. 1983 Apr;93(4):494-7
references: 6834978
references: Pediatr Dev Pathol. 2004 Sep-Oct;7(5):517-20
references: 15547776
references: Oral Surg Oral Med Oral Pathol. 1974 Nov;38(5):760-2
references: 4530965
references: Nat Rev Cancer. 2007 Dec;7(12):899-910
references: 18004397
references: Am J Surg Pathol. 2006 Dec;30(12):1576-80
references: 17122514
references: Arch Pathol Lab Med. 2005 Nov;129(11):1444-50
references: 16253025
references: Hum Pathol. 1999 Oct;30(10):1140-5
references: 10534159
references: Head Neck Pathol. 2007 Sep;1(1):38-43
references: 20614280
references: Am J Surg Pathol. 2009 Mar;33(3):401-8
references: 19011560
references: Ann Otol Rhinol Laryngol. 1995 Aug;104(8):639-45
references: 7639474
references: Arch Pathol Lab Med. 2007 Apr;131(4):530-7
references: 17425380
references: Eur Arch Otorhinolaryngol. 2007 Apr;264(4):451-3
references: 17089137
references: Virchows Arch. 2010 Dec;457(6):727-34
references: 20922408
references: Head Neck. 1992 Jul-Aug;14(4):321-7
references: 1517084
references: Histopathology. 2000 Apr;36(4):376-7
references: 10841649
references: Head Neck Pathol. 2010 Mar;4(1):77-83
references: 20237993
references: Otolaryngol Head Neck Surg. 2010 Jul;143(1):165-6
references: 20620639