title: Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6J mice.
abstract: METHODS
  This study investigated the global transcriptional and metabolic changes occurring at multiple time points over 24 wk in response to a high-fat diet (HFD).
  
  
  RESULTS
  C57BL/6J mice were fed a HFD or normal diet (ND) over 24 wk. HFD-fed mice developed early clinical indicators of obesity-related co-morbidities including fatty liver, insulin resistance, hyperglycemia and hypercholesterolemia. Time-course microarray analysis at eight time points over 24 wk identified 332 HFD responsive genes as potential targets to counteract diet-induced obesity (DIO) and related co-morbidities. Glucose regulating enzyme activity and gene expression were altered early in the HFD-fed mice. Fatty acid (FA) and triglyceride (TG) accumulation in combination with inflammatory changes appear to be likely candidates contributing to hepatic insulin resistance. Cidea seemed to be one of representative genes related to these changes.
  
  
  CONCLUSIONS
  Global transcriptional and metabolic profiling across multiple time points in liver revealed potential targets for nutritional interventions to reverse DIO. In future, new approaches targeting HFD responsive genes and hepatic metabolism could help ameliorate the deleterious effects of an HFD and DIO-related complication.
authors: Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea.
authors: Gyeong-Min
authors: GM
authors: Do
authors: Hea Young
authors: HY
authors: Oh
authors: Eun-young
authors: EY
authors: Kwon
authors: Yun-young
authors: YY
authors: Cho
authors: Su-kyung
authors: SK
authors: Shin
authors: Hae-Jin
authors: HJ
authors: Park
authors: Seon-Min
authors: SM
authors: Jeon
authors: Eunjung
authors: E
authors: Kim
authors: Cheol-Goo
authors: CG
authors: Hur
authors: Tae-Sun
authors: TS
authors: Park
authors: Mi-Kyung
authors: MK
authors: Sung
authors: Robin A
authors: RA
authors: McGregor
authors: Myung-Sook
authors: MS
authors: Choi