title: Acute hepatitis A induction of precursor B-cell acute lymphoblastic leukemia: a causal relationship?
abstract: BACKGROUND
  Precursor B-cell acute lymphoblastic leukemia accounts for 2% of all lymphoid neoplasms in the United States and occurs most frequently in childhood, but can also occur in adults with a median age of 39 years. It is more commonly seen in males and in Caucasians.
  
  
  METHODS
  We present a case of a 51-year-old Caucasian female with the development of precursor B-cell acute lymphoblastic leukemia after suffering acute hepatitis A 4 weeks prior to her diagnosis. She presented with malaise for a month without spontaneous bruising/bleeding, infections, or B-symptoms, such as fevers, night sweats, or unintentional weight loss.
  
  
  CONCLUSIONS
  Nonspecific viral transformation of bone marrow has been discussed in the literature, but we specifically describe hepatitis A-induced adult-onset precursor B-cell acute lymphoblastic leukemia, which is the first reported case in the literature.
authors: Department of Internal Medicine, Sinai Hospital, Johns Hopkins University/Sinai Hospital Program in Internal Medicine, Baltimore, Md. USA.
authors: V
authors: V
authors: Senadhi
authors: D
authors: D
authors: Emuron
authors: R
authors: R
authors: Gupta
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