title: Whole brain high-resolution functional imaging at ultra high magnetic fields: an application to the analysis of resting state networks.
abstract: Whole-brain functional magnetic resonance imaging (fMRI) allows measuring brain dynamics at all brain regions simultaneously and is widely used in research and clinical neuroscience to observe both stimulus-related and spontaneous neural activity. Ultrahigh magnetic fields (7T and above) allow functional imaging with high contrast-to-noise ratios and improved spatial resolution and specificity compared to clinical fields (1.5T and 3T). High-resolution 7T fMRI, however, has been mostly limited to partial brain coverage with previous whole-brain applications sacrificing either the spatial or temporal resolution. Here we present whole-brain high-resolution (1, 1.5 and 2mm isotropic voxels) resting state fMRI at 7T, obtained with parallel imaging technology, without sacrificing temporal resolution or brain coverage, over what is typically achieved at 3T with several fold larger voxel volumes. Using Independent Component Analysis we demonstrate that high resolution images acquired at 7T retain enough sensitivity for the reliable extraction of typical resting state brain networks and illustrate the added value of obtaining both single subject and group maps, using cortex based alignment, of the default-mode network (DMN) with high native resolution. By comparing results between multiple resolutions we show that smaller voxels volumes (1 and 1.5mm isotropic) data result in reduced partial volume effects, permitting separations of detailed spatial features within the DMN patterns as well as a better function to anatomy correspondence.
authors: Department of Cognitive Neurosciences, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands. f.demartino@maastrichtuniversity.nl
authors: Federico
authors: F
authors: De Martino
authors: Fabrizio
authors: F
authors: Esposito
authors: Pierre-Francois
authors: PF
authors: van de Moortele
authors: Noam
authors: N
authors: Harel
authors: Elia
authors: E
authors: Formisano
authors: Rainer
authors: R
authors: Goebel
authors: Kamil
authors: K
authors: Ugurbil
authors: Essa
authors: E
authors: Yacoub
references: Magn Reson Imaging. 2008 Sep;26(7):905-13
references: 18486388
references: Magn Reson Med. 2010 May;63(5):1144-53
references: 20432285
references: Magn Reson Med. 2001 Jul;46(1):24-30
references: 11443707
references: J Magn Reson Imaging. 1995 Jul-Aug;5(4):403-9
references: 7549201
references: Magn Reson Med. 2006 Jul;56(1):118-29
references: 16767760
references: Neurobiol Aging. 2012 May;33(5):886-98
references: 20739098
references: Nature. 2001 Jul 12;412(6843):150-7
references: 11449264
references: Neuroimage. 2009 Oct 1;47(4):1425-34
references: 19446641
references: IEEE Trans Neural Netw. 1999;10(3):626-34
references: 18252563
references: Neuron. 2009 Jul 30;63(2):178-88
references: 19640477
references: Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2035-40
references: 19188601
references: Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11796-801
references: 17586684
references: Neuroimage. 2005 Feb 1;24(3):738-50
references: 15652309
references: Hum Brain Mapp. 2001 May;13(1):43-53
references: 11284046
references: Magn Reson Med. 2002 May;47(5):982-9
references: 11979578
references: Magn Reson Imaging. 2009 Oct;27(8):1011-8
references: 19261421
references: Neuroimage. 2005 Mar;25(1):193-205
references: 15734355
references: Magn Reson Med. 2003 Apr;49(4):655-64
references: 12652536
references: Neuroimage. 2009 Mar 1;45(1):160-8
references: 19028588
references: Neuroimage. 2005 May 15;26(1):243-50
references: 15862224
references: J Neurophysiol. 1997 May;77(5):2780-7
references: 9163392
references: Am J Psychiatry. 2007 Mar;164(3):450-7
references: 17329470
references: Neuroimage. 2006 Jul 15;31(4):1536-48
references: 16632379
references: NMR Biomed. 1994 Mar;7(1-2):45-53
references: 8068525
references: Neuroimage. 2010 May 15;51(1):261-6
references: 20139009
references: PLoS One. 2010 Dec 20;5(12):e15710
references: 21187930
references: Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5951-5
references: 1631079
references: J Neurosci. 2005 Aug 24;25(34):7709-17
references: 16120771
references: Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5675-9
references: 1608978
references: Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734-9
references: 20176931
references: Magn Reson Med. 1997 Oct;38(4):591-603
references: 9324327
references: Magn Reson Med. 2003 Jun;49(6):1019-27
references: 12768579
references: Hum Brain Mapp. 1998;6(3):160-88
references: 9673671
references: Hum Brain Mapp. 1999;8(4):272-84
references: 10619420
references: Magn Reson Med. 1994 Oct;32(4):535-9
references: 7997122
references: Neuroimage. 2007 Apr 1;35(2):539-52
references: 17306989
references: Neuroimage. 2006 Feb 1;29(3):879-87
references: 16194614
references: Magn Reson Med. 1990 Jul;15(1):152-7
references: 2374495
references: Magn Reson Med. 1999 Nov;42(5):952-62
references: 10542355
references: Neuron. 2003 Nov 13;40(4):859-69
references: 14622588
references: PLoS Biol. 2008 Jul 1;6(7):e159
references: 18597554
references: Neuroimage. 2010 Oct 1;52(4):1334-46
references: 20460157
references: Magn Reson Med. 1993 Sep;30(3):387-92
references: 8412613
references: Neuroimage. 2009 Jun;46(2):432-46
references: 19233292
references: Magn Reson Imaging. 2009 Oct;27(8):1019-29
references: 19375260
references: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
references: 11209064
references: Neuron. 2001 Oct 25;32(2):359-74
references: 11684004
references: Magn Reson Imaging. 2004 Dec;22(10):1493-504
references: 15707799
references: Magn Reson Med. 2001 Apr;45(4):588-94
references: 11283986
references: Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53
references: 16945915
references: Magn Reson Med. 1993 Sep;30(3):380-6
references: 8412612
references: Magn Reson Imaging. 2003 Dec;21(10):1263-81
references: 14725934
references: Magn Reson Imaging. 2010 Nov;28(9):1258-69
references: 20656431
references: Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10607-12
references: 18641121
references: Hum Brain Mapp. 2006 May;27(5):392-401
references: 16596654
references: Magn Reson Imaging. 2006 Jan;24(1):1-5
references: 16410172
references: Neuroimage. 2007 Oct 1;37(4):1161-77
references: 17702606
references: Neuroreport. 1994 Mar 21;5(7):813-6
references: 8018855
references: Magn Reson Med. 1992 Jun;25(2):390-7
references: 1614324
references: Hum Brain Mapp. 2008 Jul;29(7):740-50
references: 18438886
references: J Cereb Blood Flow Metab. 2011 Feb;31(2):401-12
references: 20859295
references: Trends Neurosci. 2003 Feb;26(2):108-14
references: 12536134
references: NMR Biomed. 2006 May;19(3):368-78
references: 16705638
references: Neuroimage. 2006 May 1;30(4):1149-60
references: 16414284
references: NMR Biomed. 1994 Mar;7(1-2):69-74
references: 8068528
references: Magn Reson Med. 1993 Nov;30(5):609-16
references: 8259061
references: Neuroimage. 2009 Jan 15;44(2):448-54
references: 18835582
references: Neuroimage. 2009 May 1;45(4):1162-72
references: 19349231
references: Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8
references: 12506194
references: Front Syst Neurosci. 2010 Jun 17;4:19
references: 20592951
references: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4637-42
references: 15070770