title: [Synthesis and antitumor activities of pyrimidines].
abstract: OBJECTIVE
  To synthesize cyclin-dependent kinase (CDKs) inhibitors and assay their antitumor activities.
  
  
  METHODS
  A series of pyrimidines containing different arylamino and 1-(methylsulfonyl)piperidin moieties were designed by combining the segments 1-(methylsulfonyl)piperidin and pyrimidine heterocycles according to the super-position principle of the reinforcement of biological activities.
  
  
  RESULTS
  Their structures were characterized by MS and 1H NMR spectra and all the synthesized compounds were screened for their antimicrobial activity with MTT assay.
  
  
  CONCLUSIONS
  The preliminary bioassay showed that compound 3 b displayed good antitumor activity (IC(50)=13.6 µmol/L). The preliminary structure activity relationship analysis of these analogues suggest that the steric factor may have important impact on the anti-tumor activity.
authors: College of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. youww@fimmu.com
authors: Wen-wei
authors: WW
authors: You
authors: Pei-liang
authors: PL
authors: Zhao
authors: Min
authors: M
authors: Zou
authors: Zhong-zhen
authors: ZZ
authors: Zhou
authors: An-na
authors: AN
authors: Duan
authors: Shu-guang
authors: SG
authors: Wu