title: The development of auditory skills in infants with isolated Large Vestibular Aqueduct Syndrome after cochlear implantation.
abstract: OBJECTIVE
  The purpose of this study was to investigate the auditory performance of infants with isolated Large Vestibular Aqueduct Syndrome (LVAS) after cochlear implantation, compare their performance with those of infants with a normal inner ear, and establish a database of auditory development.
  
  
  METHODS
  435 infants with congenital severe to profound hearing loss participated in this study. 62 infants in group A were diagnosed with isolated LVAS. 373 infants in group B had a normal inner ear. Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS) was used to evaluate the development of auditory skills.
  
  
  RESULTS
  The mean scores for auditory ability showed no significant difference between groups A and B. The mean scores for the three different auditory skills increased significantly over time. The differences were statistically significant in mean scores among the three different auditory skills for group B.
  
  
  CONCLUSIONS
  Auditory skills of infants with isolated LVAS developed rapidly after cochlear implantation, in a similar manner to those of infants with a normal inner ear. Cochlear implantation is an effective interventional approach and an established therapeutic option for infants with isolated LVAS.
authors: Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education), Beijing Institute of Otolaryngology, Beijing 100005, China.
authors: Xueqing
authors: X
authors: Chen
authors: Bo
authors: B
authors: Liu
authors: Sha
authors: S
authors: Liu
authors: Lingyan
authors: L
authors: Mo
authors: Haihong
authors: H
authors: Liu
authors: Ruijuan
authors: R
authors: Dong
authors: Yongxin
authors: Y
authors: Li
authors: Shusheng
authors: S
authors: Gong
authors: Demin
authors: D
authors: Han
authors: Luo
authors: L
authors: Zhang