title: Jatrophane diterpenes from Euphorbia esula as antiproliferative agents and potent chemosensitizers to overcome multidrug resistance.
abstract: Phytochemical study of whole, undried plants of Euphorbia esula led to the isolation of six new (1-6) jatrophane diterpene polyesters, named esulatins H-M, together with the known compounds 2α,3β,5α,7β,15β-pentaacetoxy-9α-nicotinoyloxyjatropha-6(17),11-dien-14-one (7), salicinolide (8), and euphosalicin (9). The structures and relative configuration of 1-6 were established on the basis of extensive spectroscopic analysis, including HRESIMS and one- and two-dimensional NMR techniques. All these compounds, together with diterpenes (10-14) isolated previously from this plant, were evaluated for their antiproliferative activity against HeLa, Ishikawa, and MCF7 cells. The multidrug-resistance-reversing activities were also investigated on L5178 mouse lymphoma cells transfected with the pHa MDR1/A retrovirus DNA. Preliminary structure-activity relationship data are discussed.
authors: Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
authors: Andrea
authors: A
authors: Vasas
authors: Edvárd
authors: E
authors: Sulyok
authors: Dóra
authors: D
authors: Rédei
authors: Peter
authors: P
authors: Forgo
authors: Pál
authors: P
authors: Szabó
authors: István
authors: I
authors: Zupkó
authors: Ágnes
authors: Á
authors: Berényi
authors: Joseph
authors: J
authors: Molnár
authors: Judit
authors: J
authors: Hohmann