title: Interferon-gamma enhances TNF sensitivity in A172 human glioblastoma cell line.
abstract: Although human glioblastoma cell line A172 presents tumor necrosis factor (TNF) high affinity receptors, it is resistant to TNF-mediated cytotoxicity. Preincubation of cells with 10 ng/ml interferon (IFN)-gamma for 6 h causes a great increase in TNF receptor numbers (about 477%). IFN-gamma alone is not cytotoxic in A172 cells. Cells preincubated with 10 ng/ml IFN-gamma for 6 h became more sensitive to the TNF cytotoxicity (about 400%). In A172 cells the enhanced TNF receptor expression may contribute to the enhancement of TNF cytotoxicity. This observation may have importance in designing new more effective therapies for human gliomas.
authors: IST NAZL RIC CANC,DEPT EXPTL ONCOL,I-16132 GENOA,ITALY.
authors: G
authors: G
authors: Cimoli
authors: S
authors: S
authors: Parodi
authors: P
authors: P
authors: Russo