title: Plasma osteopontin levels in prediction of prognosis in acute myocardial infarction.
abstract: OBJECTIVE
  We sought to explain the clinical importance of the osteopontin (OPN) in the setting of acute ST-elevation myocardial infarction (STEMI).
  
  
  METHODS
  Eighty consecutive patients (55 = 11 years, 12 women and 68 men) and sixty healthy control subjects were included in the study. In all patients, plasma OPN levels were assessed on admission and on the third day (peak value). Creatinine kinase (CK)/CK-myocardial band (MB), troponin I and N-terminal pro-brain natriuretic factor levels and echocardiographic findings were also recorded. Patients were classified into high and low OPN groups according to the median OPN value, and monitored for the occurrence of major adverse cardiovascular events (MACE).
  
  
  RESULTS
  Patients with STEMI had higher OPN levels (23.8 [16.7-41.3] ng/ml) on admission than the control subjects (18.0 [11.3-31.5] ng/ml, P = 0.004).The third day value of OPN was significantly higher (39.2 [27.2-56.0] ng/ml) than the OPN level on admission (23.8 [16.7-41.3] ng/ml, P < 0.001). Admission and peak OPN levels were not correlated with CK/CK-MB, white blood cell counts, troponin I and the N-terminal pro-brain natriuretic factor. The plasma OPN levels were not correlated with left ventricular wall motion score index either. In the subgroups of infarct localization and reperfusion strategy, plasma OPN levels were similar. When the patients were compared according to the median OPN values, there were no differences in the occurrence of MACE between the high and low OPN groups.
  
  
  CONCLUSIONS
  This study suggests, for the first time, that the plasma OPN level increases in the first hours of the acute STEMI; however, it could not be used as a prognostic biomarker of STEMI.
authors: Department of Cardiology, Gazi University Medical School, Ankara, Turkey. drokyay@yahoo.com
authors: Kaan
authors: K
authors: Okyay
authors: Yusuf
authors: Y
authors: Tavil
authors: Asife
authors: A
authors: Sahinarslan
authors: Gulten
authors: G
authors: Tacoy
authors: Murat
authors: M
authors: Turfan
authors: Nihat
authors: N
authors: Sen
authors: Ozlem
authors: O
authors: Gurbahar
authors: Bulent
authors: B
authors: Boyaci
authors: Ridvan
authors: R
authors: Yalcin
authors: Deniz
authors: D
authors: Demirkan
authors: Atiye
authors: A
authors: Cengel