title: Brain perfusion CT for acute stroke using a 256-slice CT: improvement of diagnostic information by large volume coverage.
abstract: OBJECTIVE
  To compare a 256-slice CT with a simulated standard CT for brain CT perfusion (CTP).
  
  
  METHODS
  CTP was obtained in 51 patients using a 256-slice CT (128 detector rows, flying z-focus, 8-cm detector width, 80 kV, 120mAs, 20 measurements, 1 CT image/2.5 s). Signal-to-noise ratios (SNR) were compared in grey and white matter. Perfusion maps were evaluated for cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) in hypoperfused areas and corresponding contralateral regions. Two reconstructed 10-mm slices for simulation of a standard CT (SDCT) were compared with the complete data sets (large-volume CT, LVCT).
  
  
  RESULTS
  Adequate image quality was achieved in 50/51 cases. SNR were significantly different in grey and white matter. A perfusion deficit was present in 27 data sets. Differences between the hypoperfusions and the control regions were significant for MTT and CBF, but not for CBV. Three lesions were missed by SDCT but detected by LVCT; 24 lesions were covered incompletely by SDCT, and 6 by LVCT. 21 lesions were detected completely by LVCT, but none by SDCT.
  
  
  CONCLUSIONS
  CTP imaging of the brain using an increased detector width can detect additional ischaemic lesions and cover most ischaemic lesions completely.
authors: Department of Radiology, Klinikum rechts der Isar, Technical University, Munich, Germany. dorn@roe.med.tu-muenchen.de
authors: F
authors: F
authors: Dorn
authors: D
authors: D
authors: Muenzel
authors: R
authors: R
authors: Meier
authors: H
authors: H
authors: Poppert
authors: E J
authors: EJ
authors: Rummeny
authors: A
authors: A
authors: Huber
references: Eur Radiol. 2010 Jun;20(6):1508-14
references: 20013273
references: Eur Radiol. 2005 Nov;15 Suppl 4:D28-31
references: 16479642
references: AJNR Am J Neuroradiol. 2004 May;25(5):720-9
references: 15140710
references: Eur Radiol. 2001;11(7):1220-30
references: 11471616
references: AJNR Am J Neuroradiol. 2003 Oct;24(9):1869-75
references: 14561618
references: Neuroradiology. 2009 Jul;51(7):445-51
references: 19274457
references: AJNR Am J Neuroradiol. 2010 Jun;31(6):1003-9
references: 20110373
references: Invest Radiol. 1983 Jan-Feb;18(1):94-9
references: 6832937
references: AJNR Am J Neuroradiol. 2005 Jan;26(1):104-12
references: 15661711
references: AJNR Am J Neuroradiol. 2000 Sep;21(8):1441-9
references: 11003276
references: Neuroradiology. 2010 Dec;52(12):1095-100
references: 20386891
references: Eur Radiol. 2008 Dec;18(12):2967-74
references: 18618120
references: AJNR Am J Neuroradiol. 2005 Nov-Dec;26(10):2536-41
references: 16286398
references: Neuroradiology. 2010 Mar;52(3):175-87
references: 19953234
references: Radiology. 1980 Dec;137(3):679-86
references: 7003648
references: AJNR Am J Neuroradiol. 2001 Jun-Jul;22(6):1077-80
references: 11415901
references: Ann Neurol. 2002 Apr;51(4):417-32
references: 11921048
references: AJNR Am J Neuroradiol. 2008 Jun;29(6):1118-23
references: 18403559
references: AJNR Am J Neuroradiol. 2004 Apr;25(4):533-8
references: 15090337
references: J Appl Physiol. 1954 Jun;6(12):731-44
references: 13174454
references: Br J Radiol. 2009 Jul;82(979):561-70
references: 19221186
references: J Neurol. 2002 Jan;249(1):43-9
references: 11954867
references: AJNR Am J Neuroradiol. 2010 Apr;31(4):691-5
references: 19942712
references: Radiology. 2009 Jan;250(1):202-11
references: 19092094
references: AJNR Am J Neuroradiol. 2009 May;30(5):885-92
references: 19299489