title: Alteration of polyunsaturated fatty acid pattern of plasma phospholipids and antioxidants in cervical HPV infection and neoplasia.
abstract: The complex interactions between host immunity and infectious diseases have been documented in literature and they play a role in virus infection. Many clinical-experimental reports have stressed the importance of homeostasis of cell membranes and of the 'cell healthy indicators', namely polyunsaturated fatty acids and antioxidants in HIV infection. Today's increased incidence of heterosexual transmission of HIV has showed a strict correlation between HIV and HPV infection. According to some studies, positive HIV subjects have 40-200 times a greater risk of becoming HIV-positive. We have evaluated in 40 women with HIV infection the plasma levels of polyunsaturated fatty acids of phospholipids and vitamin E, determined by GC-MS methods, and the erythrocyte glutathione peroxidase activity (GHS-Px) by spectrophotometric techniques. The alteration of these parameters were correlated with the progression of the infection, i.e. the appearance of dysplastic or neoplastic pathologies on the uterine cervix. The differences were statistically significant (p<0.001) in subjects with cervical cancer with respect to both normal controls and patients with condylomatosis.
authors: IST S MARIA & S GALLICANO,CUTANEOUS PHYSIOPATHOL LAB,I-00153 ROME,ITALY. IST S MARIA & S GALLICANO,STD DEPT,I-00153 ROME,ITALY.
authors: M
authors: M
authors: Pozzi
authors: B
authors: B
authors: Villaccio
authors: M
authors: M
authors: Picardo
authors: E
authors: E
authors: Camera
authors: A
authors: A
authors: Dicarlo