title: Diffusion tensor imaging and cognitive function in older adults with no dementia.
abstract: OBJECTIVE
  To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia.
  
  
  METHODS
  We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps.
  
  
  RESULTS
  Memory function was associated with the medial temporal lobe cortical MD on voxel-based analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe cortical MD (p < 0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01).
  
  
  CONCLUSIONS
  Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.
authors: Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. kantarci.kejal@mayo.edu
authors: K
authors: K
authors: Kantarci
authors: M L
authors: ML
authors: Senjem
authors: R
authors: R
authors: Avula
authors: B
authors: B
authors: Zhang
authors: A R
authors: AR
authors: Samikoglu
authors: S D
authors: SD
authors: Weigand
authors: S A
authors: SA
authors: Przybelski
authors: H A
authors: HA
authors: Edmonson
authors: P
authors: P
authors: Vemuri
authors: D S
authors: DS
authors: Knopman
authors: B F
authors: BF
authors: Boeve
authors: R J
authors: RJ
authors: Ivnik
authors: G E
authors: GE
authors: Smith
authors: R C
authors: RC
authors: Petersen
authors: C R
authors: CR
authors: Jack
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