title: Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible.
abstract: OBJECTIVE
  Bone transport distraction osteogenesis provides a promising alternative to traditional grafting techniques. However, existing bone transport distraction osteogenesis devices have many limitations. The purpose of this research was to test a new device, the mandibular bone transport reconstruction plate, in an animal model with comparable mandible size to humans and to histologically and mechanically examine the regenerate bone.
  
  
  METHODS
  Eleven adult foxhounds were divided into an unreconstructed control group of 5 animals and an experimental group of 6 animals. In each animal, a 34-mm segmental defect was created in the mandible. The defect was reconstructed with a bone transport reconstruction plate. Histologic and biomechanical characteristics of the regenerate and unrepaired defect were analyzed and compared with bone on the contralateral side of the mandible after 4 weeks of consolidation.
  
  
  RESULTS
  The reconstructed defect was bridged with new bone, with little bone in the control defect. Regenerate density and microhardness were 22.3% and 42.6%, respectively, lower than the contralateral normal bone. Likewise, the anisotropy of the experimental group was statistically lower than in the contralateral bone. Half the experimental animals showed nonunion at the docking site.
  
  
  CONCLUSIONS
  The device was very stable and easy to install and activate. After 1 month of consolidation, the defect was bridged with new bone, with evidence of active bone formation. Regenerate bone was less mature than the control bone. Studies are underway to identify when the regenerate properties compare with normal bone and to identify methods to augment bone union at the docking site.
authors: Department of Prosthodontics, Baylor College of Dentistry, Texas A&M University System, Dallas, TX, USA.
authors: Lucy K
authors: LK
authors: Nagashima
authors: Michelle
authors: M
authors: Rondon-Newby
authors: Ibrahim E
authors: IE
authors: Zakhary
authors: William W
authors: WW
authors: Nagy
authors: Uriel
authors: U
authors: Zapata
authors: Paul C
authors: PC
authors: Dechow
authors: Lynne A
authors: LA
authors: Opperman
authors: Mohammed E
authors: ME
authors: Elsalanty
references: J Oral Maxillofac Surg. 2004 Apr;62(4):412-20
references: 15085505
references: Am J Phys Anthropol. 2003 Mar;120(3):252-77
references: 12567378
references: Atlas Oral Maxillofac Surg Clin North Am. 2008 Sep;16(2):287-307
references: 18710697
references: Int J Oral Maxillofac Surg. 2003 Jun;32(3):296-304
references: 12767878
references: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Sep;100(3):296-301
references: 16122656
references: Laryngoscope. 1990 Apr;100(4):364-74
references: 2181219
references: Int J Oral Maxillofac Surg. 2004 Apr;33(3):294-300
references: 15287314
references: Angle Orthod. 2000 Apr;70(2):99-111
references: 10832997
references: Br J Oral Maxillofac Surg. 2001 Oct;39(5):356-64
references: 11601816
references: J Biomech. 1984;17(5):349-61
references: 6736070
references: Plast Reconstr Surg. 2002 Apr 15;109(5):1621-9
references: 11932606
references: J Biomech. 2006;39(2):237-45
references: 16321625
references: Microsurgery. 2000;20(4):158-61
references: 10980513
references: Int J Oral Maxillofac Implants. 2006 May-Jun;21(3):380-91
references: 16796280
references: J Mater Sci Mater Med. 2007 Apr;18(4):591-7
references: 17546418
references: J Dent Res. 2002 Sep;81(9):613-7
references: 12202642
references: Plast Reconstr Surg. 2001 Nov;108(6):1555-63
references: 11711927
references: J Biomech. 1987;20(10):979-86
references: 3693379
references: Laryngoscope. 1999 Sep;109(9):1481-9
references: 10499059
references: Ultrasound Med Biol. 2006 Dec;32(12):1913-21
references: 17169703
references: Int J Oral Maxillofac Surg. 2003 Oct;32(5):515-22
references: 14759111
references: J Bone Joint Surg Am. 1966 Mar;48(2):273-88
references: 5932913
references: Int J Periodontics Restorative Dent. 2009 Oct;29(5):523-33
references: 19888496
references: Otolaryngol Clin North Am. 1991 Dec;24(6):1391-418
references: 1792077
references: Plast Reconstr Surg. 2008 Feb;121(2):563-575
references: 18300976
references: J Orthop Res. 1992 Mar;10(2):237-46
references: 1740742
references: Clin Orthop Relat Res. 1989 Feb;(239):263-85
references: 2912628
references: J Oral Maxillofac Surg. 2000 Jun;58(6):593-9; discussion 600-1
references: 10847278
references: Int J Oral Maxillofac Surg. 2006 Sep;35(9):822-7
references: 16698236
references: J Craniofac Surg. 2005 Sep;16(5):805-11
references: 16192859
references: Head Neck. 2003 Oct;25(10):816-24
references: 12966505
references: Clin Orthop Relat Res. 2004 Feb;(419):21-9
references: 15021127
references: Plast Reconstr Surg. 2006 Dec;118(7):1608-1612
references: 17102734
references: Injury. 2007 Mar;38 Suppl 1:S100-7
references: 17383479
references: Am J Otolaryngol. 1995 Jan-Feb;16(1):56-65
references: 7717475
references: Arch Otolaryngol Head Neck Surg. 1993 May;119(5):511-6
references: 8484939
references: J Biomech. 1985;18(9):717-21
references: 4077867
references: Plast Reconstr Surg. 2000 Mar;105(3):889-95
references: 10724247
references: Am J Phys Anthropol. 1993 Mar;90(3):291-306
references: 8460653
references: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jan;101(1):11-28
references: 16360604
references: Int J Oral Maxillofac Implants. 2000 Jan-Feb;15(1):95-102
references: 10697943
references: Ann Plast Surg. 2009 Oct;63(4):441-8
references: 19770704
references: Adv Dent Res. 1987 Oct;1(1):64-7
references: 3326617
references: Arch Otolaryngol Head Neck Surg. 1990 May;116(5):535-45
references: 2328111
references: Clin Orthop Relat Res. 1989 Jan;(238):249-81
references: 2910611
references: Int J Oral Maxillofac Surg. 2003 Oct;32(5):523-7
references: 14759112
references: Am J Orthod Dentofacial Orthop. 1999 Apr;115(4):448-60
references: 10194291
references: J Craniofac Surg. 2002 Mar;13(2):224-30
references: 12000878
references: J Craniofac Surg. 2007 Nov;18(6):1397-402
references: 17993888