title: Non-Gaussian diffusion in human brain tissue at high b-factors as examined by a combined diffusion kurtosis and biexponential diffusion tensor analysis.
abstract: Diffusion tensor imaging (DTI) permits non-invasive probing of tissue microstructure and provides invaluable information in brain diagnostics. Our aim was to examine approaches capable of capturing more detailed information on the propagation mechanisms and underlying tissue microstructure in comparison to the conventional methods. In this work, we report a detailed in vivo diffusion study of the human brain in an extended range of the b-factors (up to 7000 s mm(-2)) performed on a group of 14 healthy volunteers at 3T. Combined diffusion kurtosis imaging (DKI) and biexponential diffusion tensor analysis (BEDTA) were applied to quantify the attenuation curves. New quantitative indices are suggested as map parameters and are shown to improve the underlying structure contrast in comparison to conventional DTI. In particular, fractional anisotropy maps related to the slow diffusion tensor are shown to attain significantly higher values and to substantially improve white matter mapping. This is demonstrated for the specified regions of the frontal and occipital lobes and for the anterior cingulate. The findings of this work are substantiated by the statistical analysis of the whole slice histograms averaged over 14 subjects. Colour-coded directional maps related to the fast and slow diffusion tensors in human brain tissue are constructed for the first time and these demonstrate a high degree of axial co-alignment of the two tensors in the white matter regions. It is concluded that a combined DKI and BEDTA offers a promising framework for monitoring tissue alteration during development and degeneration or as a consequence of the neurological disease.
authors: Institute of Neuroscience and Medicine-4, Forschungszentrum Juelich GmbH, 52425 Juelich, Germany. f.grinberg@fz-juelich.de
authors: Farida
authors: F
authors: Grinberg
authors: Ezequiel
authors: E
authors: Farrher
authors: Joachim
authors: J
authors: Kaffanke
authors: Ana-Maria
authors: AM
authors: Oros-Peusquens
authors: N Jon
authors: NJ
authors: Shah