title: Highly stable carbon nanotube doped poly(3,4-ethylenedioxythiophene) for chronic neural stimulation.
abstract: The function and longevity of implantable microelectrodes for chronic neural stimulation depends heavily on the electrode materials, which need to present high charge injection capability and high stability. While conducting polymers have been coated on neural microelectrodes and shown promising properties for chronic stimulation, their practical applications have been limited due to unsatisfying stability. Here, poly(3,4-ethylenedioxythiophene) (PEDOT) doped with pure carbon nanotubes (CNTs) was electrochemically deposited on Pt microelectrodes to evaluate its properties for chronic stimulation. The PEDOT/CNT coated microelectrodes demonstrated much lower impedance than the bare Pt, and the PEDOT/CNT film exhibited excellent stability. For both acute and chronic stimulation tests, there is no significant increase in the impedance of the PEDOT/CNT coated microelectrodes, and none of the PEDOT/CNT films show any cracks or delamination, which have been the limitation for many conducting polymer coatings on neural electrodes. The charge injection limit of the Pt microelectrode was significantly increased to 2.5 mC/cm(2) with the PEDOT/CNT coating. Further in vitro experiments also showed that the PEDOT/CNT coatings are non-toxic and support the growth of neurons. It is expected that this highly stable PEDOT/CNT composite may serve as excellent new material for neural electrodes.
authors: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.
authors: Xiliang
authors: X
authors: Luo
authors: Cassandra L
authors: CL
authors: Weaver
authors: David D
authors: DD
authors: Zhou
authors: Robert
authors: R
authors: Greenberg
authors: Xinyan T
authors: XT
authors: Cui
references: IEEE Trans Neural Syst Rehabil Eng. 2001 Mar;9(1):2-11
references: 11482359
references: Parkinsonism Relat Disord. 2008 Nov;14(7):532-8
references: 18325819
references: IEEE Trans Biomed Eng. 1990 Nov;37(11):1118-20
references: 2276759
references: Biomaterials. 2010 Jul;31(19):5169-81
references: 20382421
references: IEEE Trans Neural Syst Rehabil Eng. 2007 Dec;15(4):502-8
references: 18198707
references: Biochem Biophys Res Commun. 2009 Jul 10;384(4):426-30
references: 19426708
references: Appl Biochem Biotechnol. 2006 Feb;128(2):117-30
references: 16484721
references: Biomed Mater. 2010 Feb;5(1):15007
references: 20124668
references: Lancet Neurol. 2004 Feb;3(2):111-8
references: 14747003
references: Biosens Bioelectron. 2007 Mar 15;22(8):1723-32
references: 17015008
references: Adv Drug Deliv Rev. 2006 Dec 1;58(14):1460-70
references: 17113677
references: Neurosurgery. 2001 Aug;49(2):363-7; discussion 367-9
references: 11504112
references: Crit Rev Toxicol. 2006 Mar;36(3):189-217
references: 16686422
references: Adv Mater. 2009 Oct 5;21(37):3764-3770
references: 26345408
references: Annu Rev Biomed Eng. 2005;7:361-401
references: 16004575
references: J Neurosci Methods. 2005 Feb 15;141(2):171-98
references: 15661300
references: J Neurosci Methods. 2004 Aug 30;137(2):141-50
references: 15262054
references: Circulation. 1997 Nov 18;96(10):3732-6
references: 9396477
references: Nano Lett. 2009 Dec;9(12):4012-8
references: 19785391
references: Hear Res. 2008 Aug;242(1-2):117-31
references: 18573323
references: Nanotechnology. 2010 Mar 19;21(11):115101
references: 20173239
references: Otol Neurotol. 2010 Sep;31(7):1062-71
references: 20601922
references: Nat Nanotechnol. 2009 Feb;4(2):126-33
references: 19197316
references: J Phys Chem B. 2009 Jul 16;113(28):9416-28
references: 19545156
references: Nanomedicine. 2010 Apr;6(2):245-56
references: 19699321
references: Neuron. 2005 Mar 3;45(5):651-60
references: 15748841
references: J Phys Chem B. 2005 Mar 17;109(10):4285-9
references: 16851493
references: J Mol Neurosci. 2000 Jun;14(3):175-82
references: 10984193
references: Expert Rev Med Devices. 2006 Sep;3(5):647-55
references: 17064249
references: Nano Lett. 2005 Jun;5(6):1107-10
references: 15943451
references: Int J Audiol. 2009;48(9):601-17
references: 19382017
references: IEEE Trans Biomed Eng. 2000 Jul;47(7):911-8
references: 10916262
references: Neurotherapeutics. 2008 Jan;5(1):86-99
references: 18164487
references: Biomaterials. 2003 Feb;24(5):777-87
references: 12485796
references: Nat Nanotechnol. 2008 Jul;3(7):434-9
references: 18654569