title: An evidence-based update on myopia and interventions to retard its progression.
abstract: Myopia is the most common human eye disorder. With its increasing prevalence and earlier age-of-onset in recent birth cohorts, myopia now affects almost 33% of adults in the United States, and epidemic proportions of 85% to 90% adults in Asian cities. Unlike children in Western populations, where the prevalence of myopia is very low (less than 5%), Asian children have prevalences as high as 29% in 7-year-olds. In addition to the direct economic and social burdens of myopia, associated ocular complications may lead to substantial vision loss. This workshop summarizes the current literature regarding myopia epidemiology, genetics, animal model studies, risk factors, and clinical treatments. Published treatment strategies to retard the progression of myopia in children, such as pharmacologic agents, progressive addition lenses, and neural adaptation programs, are outlined.
authors: National Healthcare Group Eye Institute, Singapore. drleoseowei@gmail.com
authors: Seo-Wei
authors: SW
authors: Leo
authors: Terri L
authors: TL
authors: Young
references: Invest Ophthalmol Vis Sci. 1997 Feb;38(2):334-40
references: 9040465
references: Curr Opin Ophthalmol. 2009 Sep;20(5):356-62
references: 19587595
references: Invest Ophthalmol Vis Sci. 2006 Mar;47(3):837-46
references: 16505015
references: Ophthalmology. 2002 Nov;109(11):2065-71
references: 12414416
references: Ophthalmic Physiol Opt. 1995 Sep;15(5):375-8
references: 8524558
references: Vision Res. 1995 Jan;35(1):37-50
references: 7839608
references: Br J Ophthalmol. 1989 Jul;73(7):547-51
references: 2667638
references: J Am Optom Assoc. 1993 Feb;64(2):112-6
references: 8436795
references: Optom Vis Sci. 1999 Jun;76(6):346-54
references: 10416928
references: Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3768-78
references: 18421076
references: Q Rev Biol. 1996 Dec;71(4):475-509
references: 8987172
references: Vision Res. 2001 Feb;41(3):267-73
references: 11164443
references: Invest Ophthalmol Vis Sci. 1993 Mar;34(3):690-4
references: 8449687
references: Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2748-54
references: 16043846
references: Neuron. 2004 Aug 19;43(4):447-68
references: 15312645
references: Br J Ophthalmol. 2009 Sep;93(9):1181-5
references: 19416935
references: Am J Ophthalmol. 2009 Mar;147(3):512-517.e2
references: 19026404
references: Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3324-7
references: 18408192
references: Am J Optom Physiol Opt. 1987 Jul;64(7):482-98
references: 3307440
references: Optom Vis Sci. 2001 Apr;78(4):234-9
references: 11349931
references: Acta Ophthalmol Suppl. 1988;185:29-33
references: 2853535
references: Genet Epidemiol. 2008 Jul;32(5):454-63
references: 18293391
references: Invest Ophthalmol Vis Sci. 2002 Sep;43(9):2852-8
references: 12202502
references: Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1492-500
references: 12657584
references: Invest Ophthalmol Vis Sci. 1999 Aug;40(9):1936-43
references: 10440246
references: Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4790-4
references: 18586876
references: Mol Vis. 2009;15:312-8
references: 19204786
references: Vision Res. 2002 Oct;42(22):2555-9
references: 12445849
references: Optometry. 2001 May;72(5):286-91
references: 11394838
references: Clin Exp Optom. 2003 Sep;86(5):339-45
references: 14558856
references: ILAR J. 1999 Mar;40(2):59-77
references: 11304585
references: Br J Ophthalmol. 2009 Aug;93(8):997-1000
references: 19211608
references: Int J Mol Med. 2008 Apr;21(4):429-38
references: 18360688
references: Am J Ophthalmol. 2003 Jul;136(1):82-90
references: 12834674
references: Ophthalmic Physiol Opt. 2003 Jan;23(1):71-7
references: 12535059
references: Surv Ophthalmol. 1999 Oct;44 Suppl 1:S109-115
references: 10548123
references: Am J Ophthalmol. 1997 Feb;123(2):181-7
references: 9186123
references: Arch Ophthalmol. 2008 Aug;126(8):1111-9
references: 18695106
references: Arch Ophthalmol. 2007 Jan;125(1):38-48
references: 17210850
references: Optom Vis Sci. 1991 Feb;68(2):110-6
references: 2027649
references: Ophthalmic Epidemiol. 2010 Jan-Feb;17(1):50-7
references: 20100100
references: Trans Am Ophthalmol Soc. 2007;105:132-8; discussion 138-40
references: 18427602
references: Ann Ophthalmol. 1989 May;21(5):180-2, 187
references: 2742290
references: Ophthalmology. 1999 Oct;106(10):2010-5
references: 10519600
references: Invest Ophthalmol Vis Sci. 2007 Sep;48(9):3914-22
references: 17724167
references: J Cataract Refract Surg. 2008 Apr;34(4):570-7
references: 18361977
references: Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4702-6
references: 18566461
references: Ophthalmology. 2009 Mar;116(3):572-9
references: 19167081
references: Invest Ophthalmol Vis Sci. 2009 May;50(5):2024-32
references: 19151385
references: N Engl J Med. 1985 Jun 20;312(25):1609-15
references: 4000200
references: Am J Hum Genet. 1998 Nov;63(5):1419-24
references: 9792869
references: Ann Acad Med Singap. 2004 Jan;33(1):27-33
references: 15008558
references: J AAPOS. 2008 Aug;12(4):332-9
references: 18359651
references: Acta Ophthalmol Suppl. 1991;(200):1-79
references: 1663308
references: Ophthalmology. 2008 Dec;115(12):2301-2313.e1
references: 18804868
references: Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2510-9
references: 17525178
references: Br J Ophthalmol. 2005 Feb;89(2):151-3
references: 15665343
references: J Ocul Pharmacol Ther. 1999 Feb;15(1):85-90
references: 10048351
references: Optom Vis Sci. 2005 Apr;82(4):273-8
references: 15829855
references: Acta Ophthalmol Scand. 2001 Jun;79(3):233-6
references: 11401629
references: Br J Ophthalmol. 2006 Mar;90(3):362-6
references: 16488963
references: Invest Ophthalmol Vis Sci. 1997 Feb;38(2):321-33
references: 9040464
references: Exp Eye Res. 1991 Jun;52(6):755-8
references: 1855549
references: Invest Ophthalmol Vis Sci. 1994 Dec;35(13):4344-7
references: 8002254
references: Ann Acad Med Singap. 2000 Nov;29(6):740-4
references: 11269981
references: Ophthalmic Physiol Opt. 2010 Jul;30(4):321-38
references: 20629956
references: Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4433-9
references: 17898262
references: Epidemiol Rev. 1996;18(2):175-87
references: 9021311
references: Am J Optom Arch Am Acad Optom. 1954 Apr;31(4):192-203
references: 13148296
references: Drugs. 1985 Aug;30(2):85-126
references: 3928324
references: Optom Vis Sci. 1999 Jun;76(6):397-407
references: 10416935
references: Vision Res. 2009 Sep;49(19):2386-92
references: 19632261
references: Clin Exp Optom. 2006 May;89(3):124-43
references: 16637967
references: Vision Res. 1995 May;35(9):1175-94
references: 7610579
references: Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5208-14
references: 18689702
references: Arch Ophthalmol. 2004 Dec;122(12):1760-6
references: 15596577
references: Ophthalmology. 2006 Dec;113(12):2285-91
references: 16996612
references: Vision Res. 1999 May;39(9):1585-9
references: 10343852
references: Optom Vis Sci. 2004 Feb;81(2):137-47
references: 15127933
references: Curr Eye Res. 2005 Jan;30(1):71-80
references: 15875367
references: N Y State J Med. 1975 Jun;75(7):1105-10
references: 1095980
references: Ophthalmology. 2008 Aug;115(8):1279-85
references: 18294691
references: Ophthalmology. 2002 Apr;109(4):704-11
references: 11927427
references: Optom Vis Sci. 1999 Jun;76(6):363-9
references: 10416930
references: Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3116-27
references: 19324860
references: Ophthalmic Physiol Opt. 1997 Jul;17(4):279-90
references: 9390372
references: Arch Ophthalmol. 2001 Nov;119(11):1625-8
references: 11709012
references: Vision Res. 2003 Jun;43(14):1519-31
references: 12782066
references: Invest Ophthalmol Vis Sci. 2005 Nov;46(11):3965-72
references: 16249469
references: Invest Ophthalmol Vis Sci. 2002 Feb;43(2):332-9
references: 11818374
references: J Pharmacol Exp Ther. 1991 Feb;256(2):727-33
references: 1994002
references: Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2300-7
references: 15980214
references: Optom Vis Sci. 1999 Jul;76(7):474-9
references: 10445639
references: Am J Ophthalmol. 2000 Jun;129(6):825-6
references: 10970240
references: Retina. 2000;20(4):338-41
references: 10950409
references: Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3858-63
references: 18469186
references: Optom Vis Sci. 2000 Aug;77(8):395-401
references: 10966065
references: BMC Ophthalmol. 2005 Feb 11;5:1
references: 15705207
references: Ophthalmology. 1984 Dec;91(12):1573-81
references: 6084222
references: Ophthalmology. 2001 Dec;108(12):2347-57
references: 11733284
references: Invest Ophthalmol Vis Sci. 1993 Jan;34(1):205-15
references: 8425826
references: Ciba Found Symp. 1990;155:89-102; discussion 102-14
references: 2088683
references: Ophthalmology. 2008 Jun;115(6):1053-1057.e2
references: 17964656
references: Invest Ophthalmol Vis Sci. 2007 Jan;48(1):11-7
references: 17197510
references: Ophthalmology. 2005 Jan;112(1):84-91
references: 15629825
references: Arch Ophthalmol. 2008 Apr;126(4):527-30
references: 18413523