title: α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.
abstract: We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial disease in open label studies. ATQ3 activity is dependent upon reversible 2e-redox-cycling. ATQ3 may represent a broader class of unappreciated dietary-derived phytomolecular redox motifs that digitally encode biochemical data using redox state as a means to sense and transfer information essential for cellular function.
authors: Edison Pharmaceuticals, Inc., Mountain View, CA 94043, USA. bshrader@edisonpharma.com
authors: William D
authors: WD
authors: Shrader
authors: Akiko
authors: A
authors: Amagata
authors: Adam
authors: A
authors: Barnes
authors: Gregory M
authors: GM
authors: Enns
authors: Andrew
authors: A
authors: Hinman
authors: Orion
authors: O
authors: Jankowski
authors: Viktoria
authors: V
authors: Kheifets
authors: Ryo
authors: R
authors: Komatsuzaki
authors: Edgar
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authors: Lee
authors: Paul
authors: P
authors: Mollard
authors: Katsuyuki
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authors: Murase
authors: Alfredo A
authors: AA
authors: Sadun
authors: Martin
authors: M
authors: Thoolen
authors: Kieron
authors: K
authors: Wesson
authors: Guy
authors: G
authors: Miller