title: Bone mineral density in ambulatory patients with multiple sclerosis.
abstract: Multiple sclerosis (MS) may be associated with reduced bone mass and higher frequency of osteoporosis. Femoral and spinal bone mineral density (BMD) in 70 ambulatory MS patients (46 females and 24 males) was compared with 100 sex-, age-, and BMI-matched control individuals. BMD was reduced in male patients (lumbar spine 0.976 ± 0.114 g/cm(2) compared with 1.059 ± 0.147 g/cm(2) in controls, p = 0.024, total hip 0.946 ± 0.136 g/cm(2) compared to 1.036 ± 0.118 g/cm(2) in controls, p = 0.008, femoral neck 0.812 ± 0.136 g/cm(2) compared with 0.887 ± 0.135 g/cm(2) in controls p = 0.042), and only in the total hip in female patients (0.88 ± 0.127 g/cm(2) compared with 0.935 ± 0.112 g/cm(2) in controls, p = 0.018). Multivariate analysis demonstrated that the predominantly affected site was the hip. MS patients exhibit increased frequency of low bone mass compared with controls. Further studies should assess the etiologic factors and employ appropriate therapies.
authors: Department of Nuclear Medicine, University Hospital of Ioannina, 45110 Ioannina, Greece. csioka@yahoo.com
authors: Chrissa
authors: C
authors: Sioka
authors: Stylianos
authors: S
authors: Papakonstantinou
authors: Andreas
authors: A
authors: Fotopoulos
authors: Yiannis
authors: Y
authors: Alamanos
authors: Athanasia
authors: A
authors: Georgiou
authors: Sofia
authors: S
authors: Tsouli
authors: Sygliti-Henrietta
authors: SH
authors: Pelidou
authors: Athanassios P
authors: AP
authors: Kyritsis
authors: John
authors: J
authors: Kalef-Ezra
references: Mult Scler. 2004 Apr;10(2):170-5
references: 15124763
references: J Bone Miner Metab. 2005;23(4):309-13
references: 15981027
references: Calcif Tissue Int. 1997 Aug;61(2):129-33
references: 9236259
references: Bone. 2008 Aug;43(2):332-9
references: 18519175
references: J Clin Endocrinol Metab. 2004 Oct;89(10):4923-8
references: 15472186
references: Eur J Neurol. 2005 Jul;12(7):550-6
references: 15958096
references: Neurology. 1998 Oct;51(4):1161-5
references: 9781548
references: J Womens Health Gend Based Med. 2000 May;9(4):389-95
references: 10868611
references: Bone. 2008 Dec;43(6):1115-21
references: 18793764
references: Arch Neurol. 1996 Aug;53(8):753-7
references: 8759981
references: J Bone Miner Res. 1994 Jul;9(7):1097-105
references: 7942157
references: Mult Scler. 2005 Feb;11(1):24-32
references: 15732263
references: Mult Scler. 2005 Dec;11(6):635-40
references: 16320721
references: Lancet. 2002 Jun 1;359(9321):1929-36
references: 12057569
references: J Back Musculoskelet Rehabil. 2010;23(1):25-9
references: 20231786
references: Mult Scler. 2003 Dec;9(6):600-4
references: 14664473
references: J Rehabil Res Dev. 2008;45(6):851-61
references: 19009471
references: J Neurol Sci. 2009 Dec 15;287(1-2):1-6
references: 19800081
references: J Neurol Sci. 2009 Jan 15;276(1-2):41-4
references: 18845306
references: Bone. 2006 Feb;38(2 Suppl 1):S4-9
references: 16455317
references: J Neurol. 2010 Mar;257(3):410-8
references: 19795152
references: Neurology. 1994 Sep;44(9):1687-92
references: 7936297