title: Mood and cognition in leucine-rich repeat kinase 2 G2019S Parkinson's disease.
abstract: The behavioral and cognitive features of the leucine-rich repeat kinase G2019S mutation in Parkinson's disease in the Ashkenazi Jewish population are not well described; therefore, we sought to more systematically characterize these features using a semistructured psychiatric interview and neuropsychological testing. Twenty-one Ashkenazi Jewish patients having the leucine-rich repeat kinase G2019S mutation were compared with age- and sex-matched Ashkenazi Jewish patients with Parkinson's disease without mutations. Although overall rates of affective disorders were not greater in mutation carriers, the carriers exhibited a 6-fold increased risk of premorbid affective disorders (odds ratio, 6.0; P = .10), as determined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-IV. Of interest, we identified 2 leucine-rich repeat kinase carriers with bipolar disorder; no mutation-negative subjects had this diagnosis. Performance on the Hopkins Verbal Learning Test-Revised, Judgment of Line Orientation, and Frontal Assessment Battery was consistent with previous reports and did not differ between groups. Study findings suggest a possible association between premorbid mood disorders and leucine-rich repeat kinase Parkinson's disease, warranting further evaluation.
authors: Beth Israel Medical Center, 10 Union Square East, Suite 5H, New York, NY 10003, USA. vshanker@chpnet.org
authors: Vicki
authors: V
authors: Shanker
authors: Mark
authors: M
authors: Groves
authors: Gary
authors: G
authors: Heiman
authors: Christina
authors: C
authors: Palmese
authors: Rachel
authors: R
authors: Saunders-Pullman
authors: Laurie
authors: L
authors: Ozelius
authors: Deborah
authors: D
authors: Raymond
authors: Susan
authors: S
authors: Bressman
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