title: Safety and efficacy of adjuvant chemoradiation therapy with capecitabine after resection of pancreatic ductal adenocarcinoma: a retrospective review.
abstract: OBJECTIVE
  To evaluate clinical outcomes and safety of adjuvant chemoradiation therapy (CRT) with capecitabine after resection of pancreatic adenocarcinoma at a single institution.
  
  
  METHODS
  A retrospective analysis of patients undergoing adjuvant CRT with capecitabine after resection of pancreatic ductal adenocarcinoma between 2004 and 2007 yielded a total of 55 patients. Capecitabine was administered at 850 mg/m(2) twice daily every day per week radiotherapy (45 Gy in 25 fractions) over the 5 weeks. Sixteen percent of patients (N=9) went on to receive gemcitabine.
  
  
  RESULTS
  Of 55 patients, 42 had curative (R0) resection and 13 had incomplete resection (R1). Median overall survival (OS) and progression free survival were 18.3 and 8.0 months for all patients, respectively. Patients receiving additional gemcitabine after adjuvant CRT with capecitabine showed better OS and progression free survival than those not receiving additional gemcitabine (P<0.05). In multivariate analysis, lymphovascular invasion (present vs. absent) and addition gemcitabine therapy (yes vs. no) were significant independent prognostic factors for OS (P<0.05). Local recurrence was observed in 10 patients, and distant recurrence in 26 patients, synchronously accounting for 6 recurrences. Ten patients (18.2%) had severe grade 3 toxicities.
  
  
  CONCLUSIONS
  Capecitabine-based CRT after resection of pancreatic adenocarcinoma showed favorable outcomes and tolerable toxicity profiles.
authors: Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea.
authors: Seung Tae
authors: ST
authors: Kim
authors: Jeeyun
authors: J
authors: Lee
authors: Se Hoon
authors: SH
authors: Park
authors: Jong Kyun
authors: JK
authors: Lee
authors: Kyu Taek
authors: KT
authors: Lee
authors: Kwang Hyuck
authors: KH
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authors: Jin-Seok
authors: JS
authors: Heo
authors: Seong Ho
authors: SH
authors: Choi
authors: Dong Wook
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authors: Choi
authors: Young Suk
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authors: Park
authors: Ho Yeong
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authors: Lim
authors: Won Ki
authors: WK
authors: Kang
authors: Kee-Taek
authors: KT
authors: Jang
authors: Hee Chul
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authors: Park
authors: Do Hoon
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authors: Lim
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authors: Park