title: Intravitreal foscarnet for the treatment of acyclovir-resistant acute retinal necrosis caused by varicella zoster virus.
abstract: OBJECTIVE
  To report of a case of acute retinal necrosis (ARN), successfully treated with intravitreal foscarnet.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 40-year-old man diagnosed with varicella zoster virus (VZV)-induced ARN failed standard acyclovir treatment. He was treated subsequently with intravenous foscarnet, but developed acute renal failure after 1 day of treatment. All systemic anti-viral agents were discontinued, and intravitreal foscarnet was administered weekly. After 5 injections, the retinitis was dramatically improved.
  
  
  CONCLUSIONS
  Intravitreal foscarnet was efficacious in the treatment of acyclovir-resistant ARN caused by VZV. It may be used as the sole treatment in patients with intolerance to systemic administration.
authors: Department of Ophthalmology, Seoul St. Mary's Hospital,College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Mee Yon
authors: MY
authors: Lee
authors: Kyu Seop
authors: KS
authors: Kim
authors: Won Ki
authors: WK
authors: Lee