title: Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support.
abstract: The Letter describes a strategy for the enzymatic synthesis of glycans based on a pH-responsive water-soluble polymer. In neutral condition, the polymer is water-soluble and convenient for in-solution enzymatic synthesis, whereas in acidic condition (pH lower than 4.0), the polymer disconnects with the product and becomes insoluble, which can be easily removed. A 6-Sialyl lactose analogue was synthesized as a model reaction using this approach.
authors: College of pharmacy, Nankai University, Tianjin 300071, PR China.
authors: Wenjun
authors: W
authors: Wang
authors: Lei
authors: L
authors: Li
authors: Chen
authors: C
authors: Jin
authors: Yujie
authors: Y
authors: Niu
authors: Sen
authors: S
authors: Li
authors: Ji
authors: J
authors: Ma
authors: Linfeng
authors: L
authors: Li
authors: Yu
authors: Y
authors: Liu
authors: Li
authors: L
authors: Cai
authors: Wei
authors: W
authors: Zhao
authors: Peng George
authors: PG
authors: Wang