title: Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes.
abstract: Group I CD1 (CD1a, CD1b, and CD1c) glycoproteins expressed on immature and mature dendritic cells present nonpeptide antigens (i.e., lipid or glycolipid molecules mainly of microbial origin) to T cells. Cytotoxic CD1-restricted T lymphocytes recognizing mycobacterial lipid antigens were found in tuberculosis patients. However, thanks to a complex interplay between mycobacteria and CD1 system, M. tuberculosis possesses a successful tactic based, at least in part, on CD1 downregulation to evade CD1-dependent immunity. On the ground of these findings, it is reasonable to hypothesize that modulation of CD1 protein expression by chemical, biological, or infectious agents could influence host's immune reactivity against M. tuberculosis-associated lipids, possibly affecting antitubercular resistance. This scenario prompted us to perform a detailed analysis of the literature concerning the effect of external agents on Group I CD1 expression in order to obtain valuable information on the possible strategies to be adopted for driving properly CD1-dependent immune functions in human pathology and in particular, in human tuberculosis.
authors: Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
authors: Angelo
authors: A
authors: Aquino
authors: Grazia
authors: G
authors: Graziani
authors: Ornella
authors: O
authors: Franzese
authors: Salvatore P
authors: SP
authors: Prete
authors: Enzo
authors: E
authors: Bonmassar
authors: Laura
authors: L
authors: Bonmassar
authors: Stefania
authors: S
authors: D'Atri
references: Am J Pathol. 2004 Dec;165(6):1853-63
references: 15579430
references: Blood. 2000 Dec 15;96(13):4276-84
references: 11110702
references: J Immunol. 2010 Aug 15;185(4):2261-72
references: 20644169
references: J Immunol. 2010 Feb 1;184(3):1235-41
references: 20026739
references: Immunopharmacol Immunotoxicol. 2009;31(3):499-508
references: 19555208
references: Exp Hematol. 1999 Feb;27(2):326-36
references: 10029172
references: Science. 2004 Jan 23;303(5657):523-7
references: 14684827
references: J Virol. 1993 Jan;67(1):277-87
references: 8416373
references: Int J Infect Dis. 2010 May;14(5):e366-71
references: 19762261
references: J Immunol. 2005 Mar 1;174(5):2637-44
references: 15728470
references: Vaccine. 2009 Jul 30;27(35):4818-25
references: 19538998
references: Arch Immunol Ther Exp (Warsz). 2010 Aug;58(4):313-9
references: 20526818
references: J Exp Med. 2004 Mar 1;199(5):649-59
references: 14981115
references: J Immunol. 2007 Jul 1;179(1):673-81
references: 17579090
references: Arterioscler Thromb Vasc Biol. 2006 May;26(5):1036-42
references: 16497991
references: Histopathology. 2007 Nov;51(5):649-56
references: 17927586
references: Curr Eye Res. 1996 Jun;15(6):669-79
references: 8670771
references: Vaccine. 2006 Jul 17;24(29-30):5700-7
references: 16725232
references: J Immunol. 2003 Nov 1;171(9):4792-800
references: 14568957
references: Blood. 2004 Jan 15;103(2):538-44
references: 14504105
references: Clin Exp Allergy. 2007 Jul;37(7):1083-9
references: 17581203
references: Urology. 2009 Oct;74(4):944-50
references: 19428084
references: Nature. 1992 Dec 10;360(6404):593-7
references: 1281285
references: J Interferon Cytokine Res. 1999 May;19(5):471-8
references: 10386859
references: Haematologica. 2002 Jul;87(7):679-87; discussion 687
references: 12091117
references: Blood. 2008 May 15;111(10):5037-46
references: 18337560
references: Tissue Antigens. 2009 Sep;74(3):189-204
references: 19563525
references: Stem Cells. 2002;20(5):448-59
references: 12351815
references: J Clin Immunol. 2003 May;23(3):194-201
references: 12797541
references: Br J Dermatol. 2007 Aug;157(2):249-58
references: 17489975
references: Life Sci. 1998;63(12):985-94
references: 9749821
references: Hum Vaccin. 2009 Feb;5(2):70-8
references: 19164935
references: J Biomed Sci. 2005;12(1):31-46
references: 15864737
references: Cytokine. 1998 Oct;10(10):747-55
references: 9811527
references: J Immunol. 2006 Nov 15;177(10):7024-32
references: 17082618
references: Microb Pathog. 2006 Aug-Sep;41(2-3):59-66
references: 16716561
references: Immunity. 2000 Aug;13(2):255-64
references: 10981968
references: Cell. 2007 Jul 13;130(1):37-50
references: 17632055
references: J Immunol. 2008 Mar 15;180(6):3642-6
references: 18325888
references: Allergy. 2005 Jul;60(7):944-51
references: 15932386
references: Nat Immunol. 2000 Dec;1(6):510-4
references: 11101873
references: Infect Immun. 2006 Feb;74(2):803-9
references: 16428722
references: FASEB J. 2011 Feb;25(2):544-60
references: 20956612
references: Free Radic Biol Med. 2008 Apr 1;44(7):1443-51
references: 18242195
references: Cell Immunol. 2006 May;241(1):32-7
references: 16934790
references: Cancer Immunol Immunother. 2010 Nov;59(11):1645-53
references: 20607236
references: Annu Rev Immunol. 2004;22:817-90
references: 15032598
references: Curr Top Microbiol Immunol. 2007;314:51-72
references: 17593657
references: J Immunol. 2002 Jul 1;169(1):330-9
references: 12077262
references: Adv Exp Med Biol. 1997;417:363-7
references: 9286387
references: Science. 2005 Nov 25;310(5752):1321-4
references: 16311334
references: Am J Hematol. 2010 Dec;85(12):935-42
references: 20941782
references: J Exp Med. 2006 Oct 30;203(11):2519-27
references: 17060477
references: Mult Scler. 2004 Oct;10(5):499-506
references: 15471364
references: Med Hypotheses. 2010 Mar;74(3):433-42
references: 19932569
references: Annu Rev Immunol. 1999;17:297-329
references: 10358761
references: Scand J Immunol. 2005 Jul;62(1):45-54
references: 16091124
references: J Immunol. 2000 Nov 15;165(10):5773-9
references: 11067936
references: J Immunol. 2008 Mar 15;180(6):3680-8
references: 18322173
references: Clin Exp Immunol. 2000 Nov;122(2):232-40
references: 11091280
references: J Bacteriol. 2009 May;191(10):3321-7
references: 19286800
references: Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8445-50
references: 10890914
references: Nature. 2000 Apr 20;404(6780):884-8
references: 10786796
references: Curr Opin Immunol. 2010 Feb;22(1):81-8
references: 20080041
references: J Am Acad Dermatol. 1997 Jan;36(1):19-28
references: 8996256
references: Int Immunopharmacol. 2007 Mar;7(3):321-32
references: 17276890
references: Antimicrob Agents Chemother. 1998 Mar;42(3):550-4
references: 9517931
references: Clin Cancer Res. 2005 Mar 1;11(5):1928-40
references: 15756019
references: Stem Cells. 2004;22(5):725-40
references: 15342937
references: Science. 2004 Jan 23;303(5657):527-31
references: 14739458
references: J Leukoc Biol. 2009 Aug;86(2):283-91
references: 19401395
references: Immunology. 2006 Jun;118(2):271-8
references: 16771863
references: Biochem Biophys Res Commun. 2002 Oct 11;297(5):1211-7
references: 12372416
references: J Pharm Sci. 2005 May;94(5):974-82
references: 15793803
references: BMC Microbiol. 2008 Feb 19;8:31
references: 18282300
references: J Clin Immunol. 2005 Sep;25(5):482-90
references: 16160917
references: Immunol Lett. 2007 Nov 30;114(1):38-45
references: 17945351
references: J Immunol. 2000 May 1;164(9):4790-6
references: 10779786
references: Nature. 2005 Oct 6;437(7060):906-10
references: 16208376
references: J Immunol. 2010 Jul 1;185(1):15-22
references: 20562268
references: Infect Immun. 2004 Jan;72(1):589-92
references: 14688141
references: J Leukoc Biol. 2007 Dec;82(6):1401-6
references: 17890507
references: Eur J Immunol. 2006 May;36(5):1083-92
references: 16598820
references: APMIS. 2009 Sep;117(9):672-80
references: 19703127
references: Cell Immunol. 2004 Nov-Dec;232(1-2):127-36
references: 15922722
references: Scand J Immunol. 2004 Dec;60(6):584-91
references: 15584969
references: J Immunol. 2010 Jul 1;185(1):400-9
references: 20530258
references: J Neuroimmunol. 2001 Dec 3;121(1-2):102-10
references: 11730946
references: J Immunol. 1997 Jul 1;159(1):28-35
references: 9200435
references: Clin Immunol. 2008 Nov;129(2):350-9
references: 18757244
references: J Invest Dermatol. 2001 May;116(5):721-7
references: 11348460
references: Eur J Immunol. 1997 May;27(5):1229-35
references: 9174615
references: Nat Immunol. 2003 Jun;4(6):517-23
references: 12774075
references: Int Immunopharmacol. 2008 Jul;8(7):997-1005
references: 18486911
references: Mult Scler. 2004 Feb;10(1):16-25
references: 14760948
references: Curr Opin Immunol. 2009 Aug;21(4):397-403
references: 19541469
references: J Immunol. 1993 Jan 15;150(2):579-84
references: 7678276
references: Immunology. 2005 Mar;114(3):369-74
references: 15720438
references: Blood. 2000 Jul 1;96(1):210-7
references: 10891453
references: Nucleic Acids Res. 2010 Jul;38(12):4067-78
references: 20181675
references: Cancer Immunol Immunother. 2009 Apr;58(4):603-14
references: 18802697
references: Cancer Immunol Immunother. 2005 May;54(5):506-12
references: 15750834
references: Virology. 2004 Aug 15;326(1):79-89
references: 15262497
references: Exp Hematol. 2002 Sep;30(9):1020-8
references: 12225793
references: J Clin Immunol. 2005 Jul;25(4):365-75
references: 16133993
references: Br J Haematol. 2003 Sep;122(5):829-36
references: 12930397
references: Int Immunopharmacol. 2009 Jul;9(7-8):910-7
references: 19341823
references: Exp Cell Res. 2002 May 1;275(2):243-54
references: 11969293
references: J Immunol. 2003 Dec 15;171(12):6421-30
references: 14662841
references: FEMS Immunol Med Microbiol. 2006 Feb;46(1):113-23
references: 16420604
references: Cell Microbiol. 2004 Jul;6(7):599-607
references: 15186397
references: J Invest Dermatol. 1998 Jul;111(1):31-8
references: 9665383
references: Biochem Biophys Res Commun. 2005 Nov 18;337(2):730-8
references: 16202980
references: J Immunol. 2004 Sep 15;173(6):4066-74
references: 15356156
references: Clin Cancer Res. 2007 Jul 1;13(13):3933-41
references: 17606727
references: Blood. 2000 May 1;95(9):2875-82
references: 10779434
references: Clin Exp Immunol. 2006 Nov;146(2):354-61
references: 17034589
references: J Immunol. 2002 May 1;168(9):4333-43
references: 11970975
references: Immunology. 2008 Nov;125(3):289-301
references: 18445008
references: Exp Hematol. 2000 May;28(5):575-83
references: 10812248
references: PLoS Negl Trop Dis. 2009;3(3):e399
references: 19308259
references: Br J Cancer. 2001 Dec 14;85(12):1944-51
references: 11747338
references: Nature. 1994 Dec 15;372(6507):691-4
references: 7527500
references: Immunol Cell Biol. 2010 Oct;88(7):716-26
references: 20212510
references: Biochem Pharmacol. 2004 Aug 1;68(3):441-52
references: 15242811
references: J Hematother Stem Cell Res. 2001 Aug;10(4):569-78
references: 11522239
references: J Neuroimmunol. 2007 Oct;190(1-2):177-89
references: 17936916
references: Biol Psychiatry. 2006 Feb 15;59(4):317-26
references: 16165108
references: Biol Direct. 2009 Dec 01;4:47
references: 19948070
references: J Immunol. 1998 Oct 1;161(7):3582-8
references: 9759880
references: Adv Immunol. 2009;102:1-94
references: 19477319
references: FEBS J. 2010 Jun;277(11):2416-27
references: 20553485
references: Eur J Immunol. 2008 Aug;38(8):2351-9
references: 18624350
references: J Interferon Cytokine Res. 2004 Feb;24(2):131-9
references: 14980077
references: Parasite Immunol. 2007 Oct;29(10):515-24
references: 17883454
references: Biochem Soc Trans. 2007 Nov;35(Pt 5):1325-8
references: 17956343
references: J Immunol. 2006 May 1;176(9):5191-8
references: 16621983
references: Eur J Immunol. 2007 Oct;37(10):2812-24
references: 17823891
references: J Immunol. 2010 Apr 1;184(7):3303-5
references: 20304830
references: Clin Exp Dermatol. 2004 Sep;29(5):505-12
references: 15347337
references: Clin Immunol. 2002 Mar;102(3):225-36
references: 11890709
references: Blood. 2002 Jul 1;100(1):230-7
references: 12070032
references: Virology. 2000 Aug 15;274(1):140-8
references: 10936095
references: Nat Rev Immunol. 2005 Jun;5(6):485-96
references: 15928680
references: Infect Immun. 2007 Feb;75(2):810-9
references: 17101659
references: Biomed Pharmacother. 2006 May;60(4):156-60
references: 16647239
references: Immunology. 2010 Apr;129(4):610-9
references: 20074207
references: J Exp Med. 1993 Dec 1;178(6):2249-54
references: 7504064
references: J Cell Death. 2010 Mar 3;3:1-11
references: 21072140
references: Blood. 2009 Dec 24;114(27):5481-9
references: 19864645
references: Clin Exp Immunol. 2007 Dec;150(3):397-406
references: 17900307
references: Nature. 1989 Oct 5;341(6241):447-50
references: 2477705
references: Helicobacter. 2005 Jun;10(3):214-22
references: 15904479
references: Clin Exp Immunol. 2003 Sep;133(3):350-9
references: 12930360
references: Immunobiology. 2011 Mar;216(3):275-84
references: 20851496
references: J Korean Med Sci. 2006 Apr;21(2):315-23
references: 16614521
references: J Leukoc Biol. 2000 Nov;68(5):633-40
references: 11073101
references: Semin Immunol. 2000 Dec;12(6):543-50
references: 11145860
references: J Immunol. 1999 Feb 1;162(3):1851-8
references: 9973451
references: J Immunol. 2009 Nov 15;183(10):6269-81
references: 19880448
references: Mult Scler. 2010 Dec;16(12):1513-6
references: 20739336
references: Br J Dermatol. 2001 Jun;144(6):1161-8
references: 11422036
references: Blood. 2007 Jan 15;109(2):643-52
references: 16968896
references: Immunol Lett. 2007 Oct 31;113(1):40-6
references: 17822781
references: Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):738-43
references: 16407131
references: J Immunol. 2005 Dec 1;175(11):7218-25
references: 16301626
references: Immunol Lett. 2004 Apr 30;93(1):87-95
references: 15134904
references: Tuberculosis (Edinb). 2011 Jan;91(1):86-92
references: 20888298
references: J Immunol. 2005 Aug 1;175(3):1758-66
references: 16034117
references: Eur J Immunol. 1997 Mar;27(3):756-62
references: 9079819
references: Eur J Immunol. 2007 Oct;37(10):2834-46
references: 17853407
references: J Leukoc Biol. 2007 Dec;82(6):1473-80
references: 17761954
references: J Chemother. 2001 Feb;13(1):52-8
references: 11233801
references: Br J Dermatol. 2006 Feb;154(2):211-7
references: 16433787
references: Clin Immunol. 2007 Apr;123(1):50-9
references: 17234458
references: Haematologica. 2006 Sep;91(9):1273-4
references: 16956832
references: Photochem Photobiol. 1999 Nov;70(5):766-72
references: 10568168
references: Blood. 2003 Jan 1;101(1):143-50
references: 12393446
references: Infect Immun. 2009 Nov;77(11):4947-52
references: 19720761
references: Blood. 2008 Jun 15;111(12):5610-20
references: 18310500
references: Int J Clin Lab Res. 1998;28(3):162-9
references: 9801926
references: J Virol. 2003 Oct;77(20):10943-56
references: 14512544
references: J Neuroimmunol. 2008 Jul 15;197(2):140-6
references: 18555539
references: J Exp Med. 2009 Oct 26;206(11):2497-509
references: 19808251
references: Int Immunol. 2003 Aug;15(8):915-25
references: 12882829
references: J Immunother. 2000 May-Jun;23(3):369-78
references: 10838666
references: Eur J Endocrinol. 2000 Nov;143(5):687-95
references: 11078994
references: J Neuroimmunol. 2005 Jan;158(1-2):204-12
references: 15589055
references: Eur J Immunol. 2002 Nov;32(11):3050-8
references: 12385024
references: PLoS One. 2010 May 04;5(5):e10474
references: 20454556
references: Clin Exp Immunol. 2009 Jul;157(1):48-59
references: 19659770
references: Eur J Immunol. 1998 Jan;28(1):359-69
references: 9485215
references: Infect Immun. 2003 Jun;71(6):3076-87
references: 12761085
references: J Cell Physiol. 2011 Feb;226(2):424-33
references: 20672290
references: Int Immunol. 2003 Aug;15(8):1007-15
references: 12882838
references: Novartis Found Symp. 2008;291:196-208; discussion 208-11, 221-4
references: 18575275
references: J Immunol. 2005 Nov 15;175(10):6344-51
references: 16272286
references: Eur J Endocrinol. 2001 Sep;145(3):351-7
references: 11517017
references: J Clin Immunol. 2006 Mar;26(2):153-9
references: 16598657
references: J Acquir Immune Defic Syndr. 2007 Dec 15;46(5):519-28
references: 18043312
references: Infect Immun. 2007 Apr;75(4):1667-78
references: 17210662
references: Ann Rheum Dis. 2002 Nov;61 Suppl 2:ii54-8
references: 12379623
references: Arch Dermatol. 1998 Oct;134(10):1263-8
references: 9801682
references: Int Immunopharmacol. 2007 Aug;7(8):1102-10
references: 17570327
references: Adv Immunol. 1995;59:1-98
references: 7484459
references: Inflamm Bowel Dis. 2009 Oct;15(10):1548-56
references: 19340880
references: J Immunol. 2000 May 1;164(9):4443-51
references: 10779743
references: Toxicol In Vitro. 2009 Apr;23(3):509-19
references: 19444928
references: Pediatr Res. 2005 Jul;58(1):125-31
references: 15774840
references: Blood. 2003 May 15;101(10):4005-12
references: 12531797
references: Eur J Pharmacol. 2006 May 10;537(1-3):190-9
references: 16631732
references: Reprod Biol Endocrinol. 2008 Oct 01;6:46
references: 18828896
references: J Allergy Clin Immunol. 2001 Mar;107(3):519-25
references: 11240954
references: Immunity. 2008 Jun;28(6):774-86
references: 18538591
references: Eur J Immunol. 2006 Jun;36(6):1443-52
references: 16673446
references: Int Immunopharmacol. 2005 Aug;5(9):1415-26
references: 15953568
references: Cancer Sci. 2007 Oct;98(10):1597-603
references: 17645774
references: Genome Biol. 2010;11(8):R90
references: 20799968
references: BMC Biol. 2009 May 05;7:20
references: 19416510
references: Curr Opin Immunol. 2009 Jun;21(3):331-8
references: 19505813
references: Infect Immun. 2001 Dec;69(12):7461-70
references: 11705921
references: FASEB J. 2003 Mar;17(3):491-3
references: 12514109
references: Tuberculosis (Edinb). 2009 Jan;89(1):77-83
references: 18823820
references: Immunol Cell Biol. 2011 Mar;89(3):437-46
references: 20805841
references: World J Gastroenterol. 2008 Mar 14;14(10):1617-21
references: 18330958
references: Folia Histochem Cytobiol. 2008;46(4):535-9
references: 19141410
references: Clin Exp Allergy. 1996 May;26(5):517-24
references: 8735863
references: Trends Immunol. 2008 Jul;29(7):343-51
references: 18515182
references: J Immunol. 2009 Jun 1;182(11):7030-7
references: 19454700
references: J Immunol. 2000 May 1;164(9):4843-52
references: 10779793
references: Blood. 1998 Dec 15;92(12):4778-91
references: 9845545
references: Vaccine. 2004 Sep 28;22(29-30):3848-57
references: 15364431
references: J Immunol. 2007 Jan 15;178(2):798-807
references: 17202341
references: Transplantation. 2003 Jan 15;75(1):137-45
references: 12544886
references: Vaccine. 2009 Sep 18;27(41):5581-8
references: 19651176
references: J Immunol. 2001 Sep 15;167(6):3339-45
references: 11544323
references: Clin Exp Rheumatol. 2002 Sep-Oct;20(5):683-8
references: 12412200
references: Scand J Immunol. 1999 Nov;50(5):499-509
references: 10564553
references: Cell Immunol. 2008 Jan;251(1):37-42
references: 18423589
references: Science. 1997 Jun 13;276(5319):1684-7
references: 9180075
references: Pharmacol Res. 1997 Feb;35(2):135-40
references: 9175583