title: Automated versus manual segmentation of atherosclerotic carotid plaque volume and components in CTA: associations with cardiovascular risk factors.
abstract: The purpose of this study was to validate automated atherosclerotic plaque measurements in carotid arteries from CT angiography (CTA). We present an automated method (three initialization points are required) to measure plaque components within the carotid vessel wall in CTA. Plaque components (calcifications, fibrous tissue, lipids) are determined by different ranges of Hounsfield Unit values within the vessel wall. On CTA scans of 40 symptomatic patients with atherosclerotic plaque in the carotid artery automatically segmented plaque volume, calcified, fibrous and lipid percentages were 0.97 ± 0.51 cm(3), 10 ± 11%, 63 ± 10% and 25 ± 5%; while manual measurements by first observer were 0.95 ± 0.60 cm(3), 14 ± 16%, 63 ± 13% and 21 ± 9%, respectively and manual measurement by second observer were 1.05 ± 0.75 cm(3), 11 ± 12%, 61 ± 11% and 27 ± 10%. In 90 datasets, significant associations were found between age, gender, hypercholesterolemia, diabetes, smoking and previous cerebrovascular disease and plaque features. For both automated and manual measurements, significant associations were found between: age and calcium and fibrous tissue percentage; gender and plaque volume and lipid percentage; diabetes and calcium, smoking and plaque volume; previous cerebrovascular disease and plaque volume. Significant associations found only by the automated method were between age and plaque volume, hypercholesterolemia and plaque volume and diabetes and fibrous tissue percentage. Significant association found only by the manual method was between previous cerebrovascular disease and percentage of fibrous tissue. Automated analysis of plaque composition in the carotid arteries is comparable with the manual analysis and has the potential to replace it.
authors: Biomedical Imaging Group, Departments of Medical Informatics and Radiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands. danijela.vuk@gmail.com
authors: Danijela
authors: D
authors: Vukadinovic
authors: Sietske
authors: S
authors: Rozie
authors: Marjon
authors: M
authors: van Gils
authors: Theo
authors: T
authors: van Walsum
authors: Rashindra
authors: R
authors: Manniesing
authors: Aad
authors: A
authors: van der Lugt
authors: Wiro J
authors: WJ
authors: Niessen
references: J Cardiovasc Comput Tomogr. 2009 Nov-Dec;3(6):372-82
references: 20083056
references: Eur Radiol. 2009 Sep;19(9):2294-301
references: 19384548
references: Int J Cardiovasc Imaging. 2003 Oct;19(5):419-28
references: 14609192
references: IEEE Trans Med Imaging. 2010 Jan;29(1):65-76
references: 19556191
references: Radiology. 2007 Jul;244(1):64-77
references: 17581895
references: Med Image Anal. 2006 Apr;10(2):200-14
references: 16263325
references: MAGMA. 2004 Apr;16(5):227-34
references: 15029508
references: Stroke. 2004 Oct;35(10):2306-12
references: 15345798
references: Stroke. 2000 Mar;31(3):615-21
references: 10700494
references: Stroke. 2006 Mar;37(3):818-23
references: 16469957
references: N Engl J Med. 1987 May 28;316(22):1371-5
references: 3574413
references: AJNR Am J Neuroradiol. 2008 May;29(5):875-82
references: 18272562
references: Circulation. 1998 Dec 15;98(24):2666-71
references: 9851951
references: Circulation. 2003 Oct 7;108(14):1664-72
references: 14530185
references: J Vasc Surg. 1997 Oct;26(4):585-94
references: 9357458
references: Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2366-72
references: 16902158
references: Eur J Vasc Endovasc Surg. 2006 Nov;32(5):561-7
references: 16979917
references: N Engl J Med. 1991 Aug 15;325(7):445-53
references: 1852179
references: Stroke. 2007 Mar;38(3):935-40
references: 17272781
references: Radiology. 2005 Nov;237(2):555-62
references: 16170011
references: Int J Cardiovasc Imaging. 2008 Oct;24(7):751-9
references: 18373211
references: Circulation. 2002 Sep 10;106(11):1368-73
references: 12221054
references: Stroke. 1981 Mar-Apr;12(2 Pt 2 Suppl 1):I45-57
references: 7222166
references: Magn Reson Med. 2006 Mar;55(3):659-68
references: 16470594
references: Circulation. 2004 Aug 10;110(6):756-62
references: 15277320
references: Magn Reson Imaging. 1999 Feb;17(2):257-66
references: 10215481
references: Circulation. 2004 Oct 12;110(15):2190-7
references: 15466633
references: Top Magn Reson Imaging. 2007 Oct;18(5):371-8
references: 18025991
references: Int J Cardiovasc Imaging. 2010 Aug;26(6):711-20
references: 20339922