title: p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia.
abstract: Inactive heterozygous aldehyde dehydrogenase-2 (ALDH2(*)1/(*)2) and less-active alcohol dehydrogenase-1B (ADH1B(*)1/(*)1) increase the risk of esophageal cancer in East Asian drinkers, and esophageal cancer multiplicity is strongly associated with ALDH2(*)1/(*)2. p53 alterations are key molecular events in multifocal carcinogenesis in the esophagus. We studied 260 esophageal-cancer free Japanese alcoholics with esophageal dysplasia diagnosed by biopsy of distinct iodine-unstained lesions (DIULs) ≥5mm. The degree of p53 protein accumulation was positively associated with the degree of atypia (p<0.0001) and size (p=0.040) of DIULs and with the presence of multiple DIULs (p=0.070), but not with ALDH2(*)1/(*)2 or ADH1B(*)1/(*)1.
authors: National Hospital Organization, Kurihama Alcoholism Center, Kanagawa, Japan. a_yokoyama@kurihama1.hosp.go.jp
authors: Akira
authors: A
authors: Yokoyama
authors: Yoichi
authors: Y
authors: Tanaka
authors: Tetsuji
authors: T
authors: Yokoyama
authors: Takeshi
authors: T
authors: Mizukami
authors: Toshifumi
authors: T
authors: Matsui
authors: Katsuya
authors: K
authors: Maruyama
authors: Tai
authors: T
authors: Omori