title: Isolated seizures in rats do not cause neuronal injury.
abstract: BACKGROUND
  Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain.
  
  
  METHODS
  We used structural MRI and neuropathology to study the effects of isolated seizures induced by kainic acid (KA), (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazole-4-yl)propanoic acid (ATPA), and α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate in rats. A group of animals received normal saline. After seizure induction, animals were followed for 12 weeks.
  
  
  RESULTS
  ATPA and KA led to small but significant increases in ADC. There were no changes in T2 signal intensity or hippocampal volume. Blinded pathological examination showed no differences between animals receiving saline or glutamatergic agents.
  
  
  CONCLUSIONS
  Our study suggests that isolated seizures cause minimal neuronal injury in rats.
authors: Department of Neurology, Children's National Medical Center, Washington, DC, USA.
authors: M T
authors: MT
authors: Acosta
authors: J
authors: J
authors: Munashinge
authors: L
authors: L
authors: Zhang
authors: Daniel A
authors: DA
authors: Guerron
authors: Alexander
authors: A
authors: Vortmeyer
authors: W H
authors: WH
authors: Theodore
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