title: Crystal structure of human germline antibody 3-23/B3.
abstract: The human antibody repertoire is dominated by a few combinations of germline sequences, with the genes 3-23 for the heavy chain and B3 for the light chain being among the most frequently used. Despite this fact, there was no experimental structure of the antibody composed of 3-23 and B3. The crystal structure of the Fab fragment of the synthetic antibody composed of the 3-23 and B3 germline sequences was determined to provide a template for antibody modeling. The antigen-binding loops were found in the canonical conformations. Comparison to the other structures where either 3-23 or B3 is paired with a different chain reveals a significant deviation in the orientation of the variable domains.
authors: Centocor R&D, Inc., 145 King of Prussia Road, Radnor, PA 19087, USA.
authors: Thomas J
authors: TJ
authors: Malia
authors: Galina
authors: G
authors: Obmolova
authors: Juan Carlos
authors: JC
authors: Almagro
authors: Gary L
authors: GL
authors: Gilliland
authors: Alexey
authors: A
authors: Teplyakov