title: Subventricular zone in motor neuron disease with frontotemporal dementia.
abstract: Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS.
authors: Neuromuscular Unit, Neurology Department, Hospital Clinico San Carlos, Madrid, Spain. elainvestigacion@luciagalan.es
authors: Lucia
authors: L
authors: Galan
authors: Ulises
authors: U
authors: Gomez-Pinedo
authors: Alvaro
authors: A
authors: Vela-Souto
authors: Antonio
authors: A
authors: Guerrero-Sola
authors: Juan Antonio
authors: JA
authors: Barcia
authors: Alberto Rábano
authors: AR
authors: Gutierrez
authors: Armando
authors: A
authors: Martinez-Martinez
authors: Maria Sagrario Barquero
authors: MS
authors: Jiménez
authors: Jose Manuel
authors: JM
authors: García-Verdugo
authors: Jorge
authors: J
authors: Matias-Guiu