title: A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis.
abstract: Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis. JAM-C expressed on both murine B16 melanoma cells as well as on endothelial cells promoted the transendothelial migration of the melanoma cells. We generated mice with inactivation of JAM-C. JAM-C(-/-) mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis. Together, JAM-C represents a novel therapeutic target for melanoma metastasis.
authors: Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.
authors: Harald F
authors: HF
authors: Langer
authors: Valeria V
authors: VV
authors: Orlova
authors: Changping
authors: C
authors: Xie
authors: Sunil
authors: S
authors: Kaul
authors: Darius
authors: D
authors: Schneider
authors: Anke S
authors: AS
authors: Lonsdorf
authors: Manuela
authors: M
authors: Fahrleitner
authors: Eun Young
authors: EY
authors: Choi
authors: Vanessa
authors: V
authors: Dutoit
authors: Manuela
authors: M
authors: Pellegrini
authors: Sylvia
authors: S
authors: Grossklaus
authors: Peter P
authors: PP
authors: Nawroth
authors: Gustavo
authors: G
authors: Baretton
authors: Sentot
authors: S
authors: Santoso
authors: Sam T
authors: ST
authors: Hwang
authors: Bernd
authors: B
authors: Arnold
authors: Triantafyllos
authors: T
authors: Chavakis
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