title: Assessment of gastroesophageal reflux disease by serodiagnosis of Helicobacter pylori-related chronic gastritis stage.
abstract: OBJECTIVE
  To evaluate the association of Helicobacter pylori (H.pylori)-related chronic gastritis stage with upper gastrointestinal symptoms and gastroesophageal reflux disease (GERD).
  
  
  METHODS
  Subjects underwent upper gastrointestinal endoscopy, a questionnaire using a frequency scale for symptoms of GERD (FSSG), and measurements of serum H.pylori-antibody and pepsinogen (PG) levels. They were classified into the following 4 groups in terms of H.pylori-related chronic gastritis stage: Group A (n = 219), H.pylori(-)PG(-); Group B (n = 310), H.pylori(+)PG(-); Group C (n = 279), H.pylori(+)PG(+); and Group D (n = 17), H.pylori(-)PG(+).
  
  
  RESULTS
  Reflux esophagitis occurred in 30.6% of Group A, 14.5% of Group B, 6.8% of Group C, and 0% of Group D (P < 0.001). Scores for acid reflux symptoms decreased significantly with chronic gastritis stage (from Group A to D) (P < 0.05), while scores for dysmotility symptoms did not differ significantly. The prevalence of non-erosive reflux disease (NERD) did not differ among groups. However, in subjects with GERD, the prevalence of NERD tended to increase with chronic gastritis stage (P = 0.081).
  
  
  CONCLUSIONS
  Acid reflux symptoms and the prevalence of reflux esophagitis can be assessed by measuring both serum H.pylori-antibody and PG levels.
authors: Shotaro Enomoto, Masashi Oka, Chizu Mukoubayashi, Mika Watanabe, Kosaku Moribata, Yosuke Muraki, Naoki Shingaki, Hisanobu Deguchi, Kazuki Ueda, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Kimihiko Yanaoka, Hideyuki Tamai, Masao Ichinose, Second Department of Internal Medicine, Wakayama Medical University, Wakayama 641-0012, Japan.
authors: Shotaro
authors: S
authors: Enomoto
authors: Masashi
authors: M
authors: Oka
authors: Hiroshi
authors: H
authors: Ohata
authors: Chizu
authors: C
authors: Mukoubayashi
authors: Mika
authors: M
authors: Watanabe
authors: Kosaku
authors: K
authors: Moribata
authors: Yosuke
authors: Y
authors: Muraki
authors: Naoki
authors: N
authors: Shingaki
authors: Hisanobu
authors: H
authors: Deguchi
authors: Kazuki
authors: K
authors: Ueda
authors: Izumi
authors: I
authors: Inoue
authors: Takao
authors: T
authors: Maekita
authors: Mikitaka
authors: M
authors: Iguchi
authors: Kimihiko
authors: K
authors: Yanaoka
authors: Hideyuki
authors: H
authors: Tamai
authors: Mitsuhiro
authors: M
authors: Fujishiro
authors: Osamu
authors: O
authors: Mohara
authors: Masao
authors: M
authors: Ichinose
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