title: The role of antibiotic prophylaxis in totally implantable venous access device placement: results of a single-center prospective randomized trial.
abstract: BACKGROUND
  This study evaluated whether prophylactic treatment with a cefazolin could prevent infections in patients who had a surgically inserted totally implantable venous access device (TIVAD).
  
  
  METHODS
  We conducted a prospective, randomized, double-blind, placebo-controlled trial comparing wound infection rates in 404 patients (203 received prophylactic cefazolin, 201 received a placebo) undergoing TIVAD insertion. Infections were evaluated 3, 7, 14, and 30 days after discharge and outcomes were compared and analyzed.
  
  
  RESULTS
  Groups were well matched for all preoperative variables studied, including comorbid conditions. Superficial surgical site infection developed in 5 patients (2.5%) from the antibiotic group and 6 (3%) from the placebo group (P = .75). One from each group developed deep surgical site infection. Both patients were readmitted and underwent repeated debridement, which eventually resulted in port loss in 1 patient.
  
  
  CONCLUSIONS
  We do not recommend the use of prophylactic antibiotics in TIVAD insertion because they will not decrease the already low rate of postoperative infectious complications. Registration number NCT00867295 (http://www.clinicaltrials.gov).
authors: Department of Surgery, Istanbul University, Institute of Oncology, Capa, Turkey. hasankaranlik@yahoo.com
authors: Hasan
authors: H
authors: Karanlik
authors: Sidika
authors: S
authors: Kurul
authors: Pinar
authors: P
authors: Saip
authors: Ersin Selcuk
authors: ES
authors: Unal
authors: Fatma
authors: F
authors: Sen
authors: Rian
authors: R
authors: Disci
authors: Erkan
authors: E
authors: Topuz