title: Offspring metabolomic response to maternal protein restriction in a rat model of intrauterine growth restriction (IUGR).
abstract: Intrauterine growth restriction (IUGR), along with postnatal growth trajectory, is closely linked with metabolic diseases and obesity at adulthood. The present study reports the time-dependent metabolomic response of male offspring of rat dams exposed to maternal adequate protein diet during pregnancy and lactation (CC) or protein deprivation during pregnancy only (IUGR with rapid catch-up growth, RC) or through pregnancy and lactation (IUGR with slow postnatal growth, RR). Plasma LC-HRMS metabolomic fingerprints for 8 male rats per group, combined with multivariate statistical analysis (PLS-DA and HCA), were used to study the impact of IUGR and postnatal growth velocity on the offspring metabolism in early life (until weaning) and once they reached adulthood (8 months). Compared with CC rats, RR pups had clear-cut alterations in plasma metabolome during suckling, but none at adulthood; in contrast, in RC pups, alterations in metabolome were minimal in early life but more pronounced in the long run. In particular, our results pinpoint transient alterations in proline, arginine, and histidine in RR rats, compared to CC rats, and persistent differences in tyrosine and carnitine, compared to RC rats at adulthood. These findings suggest that the long-term deregulation in feeding behavior and fatty acid metabolism in IUGR rats depends on postnatal growth velocity.
authors: INRA and University of Nantes, UMR-1280 Physiologie des Adaptations Nutritionnelles CHU Hôtel Dieu, 44093 Nantes cedex 1, France. Marie-Cecile.Alexandre-Gouabau@univ-nantes.fr
authors: Marie-Cécile
authors: MC
authors: Alexandre-Gouabau
authors: Frédérique
authors: F
authors: Courant
authors: Gwénaëlle
authors: G
authors: Le Gall
authors: Thomas
authors: T
authors: Moyon
authors: Dominique
authors: D
authors: Darmaun
authors: Patricia
authors: P
authors: Parnet
authors: Bérengère
authors: B
authors: Coupé
authors: Jean-Philippe
authors: JP
authors: Antignac