title: Interlaboratory evaluation of VITEK2 system and Sensititre YeastOne® for antifungal susceptibility testing of yeasts isolated from blood cultures against four antifungal agents.
abstract: An interlaboratory evaluation (seven centers) of VITEK2 System and Sensititre YeastOne® was conducted to test the antifungal susceptibilities of yeasts. The MICs of amphotericin B, fluconazole, flucytosine, and voriconazole were determined for 70 isolates of Candida spp. Our results demonstrated a higher interlaboratory agreement of VITEK 2 System than Sensititre YeastOne©. A good concordance between the two methods was observed for amphotericin B, fluconazole, voriconazole and 5-fluorocytosine (from 81.4% to 88.6%). The study suggests the potential value of the VITEK2 System as a convenient alternative method for testing the susceptibility of yeasts. It also indicates the need for further optimization of MIC endpoint criteria to improve interlaboratory agreement.
authors: Comitato Studio Micologia (CoSM), Associazione Microbiologi Clinici Italiani, Milano, Italia. farina.claudio@sancarlo.mi.it
authors: Claudio
authors: C
authors: Farina
authors: Esther
authors: E
authors: Manso
authors: Stefano
authors: S
authors: Andreoni
authors: Marco
authors: M
authors: Conte
authors: Paolo
authors: P
authors: Fazii
authors: Gianluigi
authors: G
authors: Lombardi
authors: Silvana
authors: S
authors: Sanna
authors: Giuseppe
authors: G
authors: Russello