title: Simplextones A and B, unusual polyketides from the marine sponge Plakortis simplex.
abstract: Two novel polyketides, simplextones A (1) and B (2), were isolated from the sponge Plakortis simplex. Their structures were established by spectroscopic methods. The absolute configurations were assigned by modified Mosher's method, X-ray crystallographic analysis, and quantum mechanical calculation of the electronic circular dichroism (ECD) spectrum. Compounds 1 and 2 featured an unprecedented polyketide skeleton via the connection of a single carbon-carbon bond to form a cyclopentane. These compounds also exhibited moderate cytotoxicity.
authors: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People's Republic of China.
authors: Xiang-Fang
authors: XF
authors: Liu
authors: Yun-Long
authors: YL
authors: Song
authors: Hong-Jun
authors: HJ
authors: Zhang
authors: Fan
authors: F
authors: Yang
authors: Hao-Bing
authors: HB
authors: Yu
authors: Wei-Hua
authors: WH
authors: Jiao
authors: Shu-Juan
authors: SJ
authors: Piao
authors: Wan-Sheng
authors: WS
authors: Chen
authors: Hou-Wen
authors: HW
authors: Lin