title: Inhibitors of histone demethylases.
abstract: Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared. Most of the inhibitors are either previously reported inhibitors of related enzymes or compounds derived from these. Development in terms of selectivity and potency is still pertinent. Several reports on the development of functional assays have been published.
authors: Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2 Universitetsparken, DK-2100 Copenhagen, Denmark.
authors: Brian
authors: B
authors: Lohse
authors: Jesper L
authors: JL
authors: Kristensen
authors: Line H
authors: LH
authors: Kristensen
authors: Karl
authors: K
authors: Agger
authors: Kristian
authors: K
authors: Helin
authors: Michael
authors: M
authors: Gajhede
authors: Rasmus P
authors: RP
authors: Clausen