title: Endothelial progenitor cells in acute ischemic kidney injury: strategies for increasing the cells' renoprotective competence.
abstract: Acute ischemic kidney injury is the most frequent cause of acute renal failure in daily clinical practice. It has become increasingly recognized that microvascular endothelial cell dysfunction (ED) in peritubular capillaries inhibits the process of postischemic renal reperfusion. ED can serve as therapeutic target in the management of acute ischemic kidney injury. Postischemic reflow can be restored by systemic administration of either mature endothelial cells or of endothelial progenitor cells. Endothelial progenitor cells EPCs can be cultured from the peripheral circulation of humans and different animals. The cells act vasoprotectively by direct and indirect mechanisms. The protective effects of EPCs in acute ischemic kidney injury can be stimulated by preincubating the cells with different agonistic mediators. This paper summarizes the currently available data on strategies to improve the renoprotective activity of EPCs in acute ischemic kidney injury.
authors: Department of Nephrology and Rheumatology, University Medical Center, Robert-Koch-Straße 40, 37075 Göttingen, Germany.
authors: D
authors: D
authors: Patschan
authors: S
authors: S
authors: Patschan
authors: G A
authors: GA
authors: Müller
references: Thromb Haemost. 2007 Nov;98(5):930-9
references: 18000595
references: Blood. 2005 Sep 1;106(5):1525-31
references: 15905185
references: J Clin Invest. 2000 Jan;105(1):71-7
references: 10619863
references: Am J Physiol Renal Physiol. 2006 Jan;290(1):F159-66
references: 16106036
references: Ann Neurol. 2010 Apr;67(4):488-97
references: 20437584
references: J Clin Psychiatry. 2005;66 Suppl 9:3-9; quiz 42-3
references: 16336035
references: Am J Physiol Renal Physiol. 2001 Nov;281(5):F887-99
references: 11592947
references: Circulation. 2004 Apr 13;109(14):1769-75
references: 15066951
references: Am J Physiol Renal Physiol. 2002 Jun;282(6):F1150-5
references: 11997332
references: J Cell Biol. 1994 Jun;125(6):1353-69
references: 8207063
references: J Clin Invest. 1972 Jan;51(1):118-26
references: 5007042
references: J Am Soc Nephrol. 2008 Dec;19(12):2321-30
references: 18715993
references: Nat Med. 1999 Apr;5(4):434-8
references: 10202935
references: Circ Res. 2002 Feb 22;90(3):284-8
references: 11861416
references: Trends Cardiovasc Med. 2004 Nov;14(8):318-22
references: 15596109
references: Science. 1997 Feb 14;275(5302):964-7
references: 9020076
references: Exp Hematol. 2007 Jul;35(7):1109-18
references: 17588480
references: Blood. 2009 Oct 22;114(17):3707-16
references: 19706882
references: Curr Opin Pharmacol. 2006 Apr;6(2):176-83
references: 16487748
references: Ther Adv Cardiovasc Dis. 2008 Jun;2(3):199-213
references: 19124422
references: Circulation. 2001 Jun 12;103(23):2776-9
references: 11401930
references: Cell Signal. 2010 Mar;22(3):527-32
references: 19922791
references: Circulation. 1973 Sep;48(3):455-8
references: 4726229
references: Stem Cells. 2008 Jul;26(7):1749-57
references: 18467662
references: J Clin Invest. 2004 Aug;114(3):330-8
references: 15286799
references: Cell Tissue Res. 2003 Oct;314(1):61-8
references: 12915980
references: Am J Physiol Renal Physiol. 2006 Jul;291(1):F176-85
references: 16478972
references: Circ Res. 2007 Apr 27;100(8):1234-41
references: 17379833
references: Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H525-32
references: 15277196
references: Prog Neurobiol. 2007 Dec;83(6):349-62
references: 17884277
references: Blood. 2003 Aug 15;102(4):1340-6
references: 12702503
references: Kidney Int. 2004 Aug;66(2):641-6
references: 15253717
references: Blood. 2008 Mar 1;111(5):2640-6
references: 18032709
references: J Cell Biol. 1997 Mar 10;136(5):1109-21
references: 9060475
references: Catheter Cardiovasc Interv. 2007 Oct 1;70(4):477-84
references: 17894361
references: J Am Soc Nephrol. 2010 Jun;21(6):911-9
references: 20395371
references: Am J Physiol Renal Physiol. 2010 Jan;298(1):F78-85
references: 19906949
references: J Clin Apher. 2009;24(5):180-5
references: 19753649
references: Circ Res. 2009 Jan 2;104(1):32-40
references: 19023133
references: Circulation. 2002 Aug 27;106(9):1133-9
references: 12196341
references: Curr Opin Lipidol. 2007 Oct;18(5):534-9
references: 17885424
references: Dtsch Med Wochenschr. 2003 May 30;128(22):1231-6
references: 12772081
references: Adv Exp Med Biol. 2010;674:1-7
references: 20549935
references: Circ Res. 1999 Aug 6;85(3):221-8
references: 10436164
references: J Am Soc Nephrol. 2007 May;18(5):1516-24
references: 17409313
references: Kidney Int. 2007 Jul;72(2):151-6
references: 17495858
references: Vasc Med. 2006 Nov;11(4):219-26
references: 17390544
references: Ther Adv Cardiovasc Dis. 2008 Oct;2(5):341-8
references: 19124432
references: Annu Rev Pharmacol Toxicol. 2010;50:355-75
references: 20055708
references: Biochim Biophys Acta. 2009 Aug;1796(1):50-4
references: 19393290
references: Chronobiol Int. 2004 Jan;21(1):1-25
references: 15129821
references: Microvasc Res. 2010 May;79(3):174-7
references: 20085776
references: Am J Physiol Renal Physiol. 2002 Jun;282(6):F1140-9
references: 11997331
references: Stem Cell Rev Rep. 2011 Mar;7(1):208-20
references: 20526754
references: J Nephrol. 2008 Sep-Oct;21(5):657-62
references: 18949719
references: Blood. 2007 Mar 1;109(5):1801-9
references: 17053059
references: Circ Res. 2004 Aug 20;95(4):343-53
references: 15321944
references: Nat Med. 2002 Jun;8(6):607-12
references: 12042812
references: Cardiovasc Radiat Med. 2002 Jul-Dec;3(3-4):221-5
references: 12974378
references: Blood Purif. 2010;29(3):300-7
references: 20130395
references: Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):684-90
references: 14988094
references: Annu Rev Med. 2005;56:79-101
references: 15660503
references: Circulation. 2001 Feb 6;103(5):634-7
references: 11156872
references: Prog Brain Res. 2010;181:127-51
references: 20478436
references: N Engl J Med. 2006 Sep 21;355(12):1222-32
references: 16990385
references: Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):816-22
references: 19342598
references: J Cell Sci. 2009 Nov 15;122(Pt 22):4009-11
references: 19910492
references: Biochem Soc Trans. 2000;28(4):311-39
references: 10961914
references: Development. 1994 Sep;120(9):2539-53
references: 7956830
references: Blood. 2004 Jan 1;103(1):13-9
references: 12958072
references: Hypertension. 2005 Mar;45(3):321-5
references: 15655116
references: Mol Biol Cell. 2010 Feb 15;21(4):584-96
references: 20032304
references: Circulation. 2004 Jun 22;109(24):2986-92
references: 15184289
references: Circulation. 2003 Mar 4;107(8):1164-9
references: 12615796
references: Int J Neurosci. 2010 Sep;120(9):583-90
references: 20707632
references: Circulation. 2002 Apr 2;105(13):1541-4
references: 11927518