title: Effects of the ABO-mismatch between donor and recipient of cryopreserved arterial homografts.
abstract: OBJECTIVE
  Cryopreserved arterial homograft (CAH) is a well-established substitute material for in situ reconstruction of vascular infections. However, their degeneration remains serious complication. Although several studies propose ABO-mismatching between CAH-donor and -recipient as the main reason, the results are controversial. We compared the outcome between ABO-compatible and ABO-incompatible CAH recipients to evaluate the contribution of ABO-mismatching.
  
  
  METHODS
  Between January 2004 and December 2007, a retrospective review in 32 patients who underwent CAH-implantation was performed. The patients were divided in ABO-incompatible (group A: 17/32 patients; 53%) and ABO-compatible (group B: 15/32 patients; 47%) to CAH donor. Leucocytes, platelets and C-reactive protein (CRP) levels were recorded during the in-hospital stay. These were correlated with the surface of implanted homograft (SIH). Mid-term survival- and freedom-from-reoperation (FFR) rates were also calculated.
  
  
  RESULTS
  In both groups, peak of leucocytes and CRP was recorded on third postoperative day (POD3) and regarding platelets lowest values on POD1. Interestingly, a second CRP-peak was reported on POD8 in group A (A: 172±104mg/L vs. B: 75±55mg/L, P=0.01). No relationship between second CRP-peak and SIH was found. After 27 months median follow-up (range, 5-49 months), survival- (65% vs. 84%, P=0.28) and FFR-rates (94% vs. 93%, P=0.98) remained comparable.
  
  
  CONCLUSIONS
  We consider that the second CRP-peak expresses an early cytoimmunologic response of ABO-incompatible recipients against CAH. However, we did not find any relationship between ABO-incompatibility and poor mid-term outcome in terms of reoperation or mortality. Longer surveillance of our patients is mandatory.
authors: Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover, Germany. bisdas.theodosios@mh-hannover.de
authors: T
authors: T
authors: Bisdas
authors: M
authors: M
authors: Pichlmaier
authors: M
authors: M
authors: Wilhelmi
authors: S
authors: S
authors: Bisdas
authors: A
authors: A
authors: Haverich
authors: O E
authors: OE
authors: Teebken