title: Abnormalities in the enamel in bmp2-deficient mice.
abstract: Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal molecular signaling. Bone morphogenetic protein 2 (Bmp2) is essential for tooth formation. However, the role of Bmp2 during enamel formation remains unknown in vivo. In this study, the role of Bmp2 in the regulation of postnatal enamel formation was investigated via the conditional ablation of Bmp2 in enamel using the (Osx-Cre) mouse. Bmp2 gene ablation was confirmed by PCR analysis in Osx-Cre, Bmp2(flox/flox) mice. Bmp2-null mice displayed a severe and profound tooth phenotype with asymmetric and open forked incisors. Microradiographs revealed broken incisor tips and dental pulp chamber exposure. The enamel layer of incisors and molars was thin with hypomineralization. Scanning electron microscopy analysis showed that the enamel surface was rough with chipping and the enamel lacked a typical prismatic architecture. These results demonstrate that Bmp2 is essential for enamel formation.
authors: The University of Texas Health Science Center at San Antonio, San Antonio, Tex., USA.
authors: Junsheng
authors: J
authors: Feng
authors: Guobin
authors: G
authors: Yang
authors: Guohua
authors: G
authors: Yuan
authors: Jelica
authors: J
authors: Gluhak-Heinrich
authors: Wuchen
authors: W
authors: Yang
authors: Lynn
authors: L
authors: Wang
authors: Zhi
authors: Z
authors: Chen
authors: Jennifer
authors: J
authors: Schulze McDaniel
authors: Kevin J
authors: KJ
authors: Donly
authors: Stephen E
authors: SE
authors: Harris
authors: Mary
authors: M
authors: Macdougall
authors: Shuo
authors: S
authors: Chen
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