title: Evidence of involvement of the receptor for advanced glycation end-products (RAGE) in the adhesion of Helicobacter pylori to gastric epithelial cells.
abstract: The adherence of Helicobacter pylori to gastric epithelial cells is required for prolonged persistence in the stomach and for induction of injury. Here, we first reported a new role of the receptor for advanced glycation end-products (RAGE) on the adherence of H. pylori to gastric epithelial cells, assessed by different methods and binding to immobilized RAGE. RAGE-targeted knock-down in MKN74 cell line markedly reduced not only the adhesion of H. pylori, but also the levels of IL-8 transcripts and protein released in response to infection. These data suggest that RAGE may represent a new factor on the pathogenesis of H. pylori infection.
authors: Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave., Talca, Chile. arojasr@ucm.cl
authors: Armando
authors: A
authors: Rojas
authors: Ileana
authors: I
authors: González
authors: Boris
authors: B
authors: Rodríguez
authors: Jacqueline
authors: J
authors: Romero
authors: Héctor
authors: H
authors: Figueroa
authors: Jorge
authors: J
authors: Llanos
authors: Erik
authors: E
authors: Morales
authors: Ramón
authors: R
authors: Pérez-Castro