title: Stimulatory effects of amphetamine on the development of Walker-256 carcinoma lung metastases in rats.
abstract: Experiments were performed in order to evaluate the effects of amphetamine (0.4 mg/kg/day) on the development of lung metastases in rats injected i.v. with 10(4) Walker 256 (W-256) carcinosarcoma cells, The number of metastatic nodules on the surface of the lungs, as well as the percentage-area of metastases in the frontal section through pulmonary hilus were increased in rats injected with amphetamine in comparison with those injected with placebo. Survival periods were also assessed and amphetamine was found to increase the lethality of rats.
authors: UNIV SANTIAGO DE COMPOSTELA,DEPT PHARMACOL,E-15705 SANTIAGO,SPAIN. UNIV SANTIAGO DE COMPOSTELA,DEPT NURSING,E-15705 SANTIAGO,SPAIN. UNIV SANTIAGO DE COMPOSTELA,DEPT PSYCHOBIOL,E-15705 SANTIAGO,SPAIN. UNIV SANTIAGO DE COMPOSTELA,DEPT SURG,E-15705 SANTIAGO,SPAIN. UNIV SANTIAGO DE COMPOSTELA,DEPT BIOCHEM,E-15705 SANTIAGO,SPAIN.
authors: M
authors: M
authors: Freiregarabal
authors: M
authors: M
authors: Nuneziglesias
authors: C
authors: C
authors: Losada
authors: M
authors: M
authors: Pereiroraposo
authors: C
authors: C
authors: Castrobolano
authors: J
authors: J
authors: Heras
authors: P
authors: P
authors: Riveiro
authors: J
authors: J
authors: Mayan
authors: M
authors: M
authors: Reymendez