title: Catalytic asymmetric synthesis of trisubstituted aziridines.
abstract: A method is described which provides for the direct asymmetric catalytic synthesis of trisubstituted aziridines from imines and diazo compounds. While unactivated imines were not reactive to α-diazo carbonyl compounds in which the diazo carbon was disubstituted, N-Boc imines react with both α-diazo esters and α-diazo-N-acyloxazolidinones to give trisubstituted aziridines with excellent diastereo- and enantioselectivities.
authors: Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
authors: Li
authors: L
authors: Huang
authors: William D
authors: WD
authors: Wulff