title: Relationship between RANTES polymorphisms and respiratory syncytial virus bronchiolitis in a Japanese infant population.
abstract: Respiratory syncytial virus (RSV) is the most important virus associated with bronchiolitis in infants and young children. The regulated upon activation, normal T-cell expressed and secreted protein (RANTES, also known as CCL5) appears to be a key player in the etiology of RSV-infected airway inflammation. In this study, we genotyped three single-nucleotide polymorphisms in the RANTES gene: -403G/A, -28C/G, and In1.1T/C in 59 infants with severe RSV bronchiolitis and 201 control subjects. The frequencies of the -403G/A+A/A, -28C/G+G/G, and In1.1T/C+C/C genotypes were significantly lower in patients with severe RSV bronchiolitis than in control subjects, and the frequencies of the -403A, -28G, and In1.1C alleles were significantly lower in RSV patients than in control subjects. The present results suggest that RANTES polymorphisms may confer risk for severe RSV bronchiolitis.
authors: Department of Public Health, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
authors: Satoshi
authors: S
authors: Hattori
authors: Naoki
authors: N
authors: Shimojo
authors: Toichi
authors: T
authors: Mashimo
authors: Yuzaburo
authors: Y
authors: Inoue
authors: Yasuhiko
authors: Y
authors: Ono
authors: Yoichi
authors: Y
authors: Kohno
authors: Yoshitaka
authors: Y
authors: Okamoto
authors: Akira
authors: A
authors: Hata
authors: Yoichi
authors: Y
authors: Suzuki