title: [The capping protein on the slow-growing end of actin filament: erythrocyte tropomodulin].
abstract: Erythrocyte tropomodulin (E-Tmod) is first isolated from human erythrocyte membrane as a TM-binding protein. Its N-terminus contains two TM-binding sites and one TM-dependent actin capping domain and C-terminus contains 5 leucine-rich repeats and a TM-independent actin capping domain. As the unique capping protein at the slow-growing end of F-actin, E-Tmod binds to N-terminus of TM and actin and decreases the TM-coated F-actin depolymerization. E-Tmod encoding gene is highly conserved and E-Tmod is distributed widely in erythrocytes and cardiomyocytes, etc. E-Tmod plays a pivotal role in organizing F-actin and cytoskeleton and maintaining the mechanical properties of the cells.
authors: Hemorheology Center, Peking University Health Science Center, Beijing 100191, China.
authors: Xiao-Lan
authors: XL
authors: Zhang
authors: Zong-Yao
authors: ZY
authors: Wen
authors: Wei-Juan
authors: WJ
authors: Yao