title: Synthesis and structural revision of phomopsin B, a novel polyketide carrying a 10-membered cyclic-ether ring.
abstract: Total synthesis of the proposed structure 2 for phomopsin B was achieved by using an intramolecular olefin metathesis as a key step. The spectral data, however, did not match with those of the natural product reported. Re-examination of the reported NMR data led to the structural revision of phomopsin B to known dothiorelone A 18. The R configuration of dothiorelone A was determined by total synthesis through a cross-metathesis with a chiral olefin 19.
authors: RIKEN, Wako, Saitama 351-0198, Japan.
authors: Yuko
authors: Y
authors: Izuchi
authors: Hiroyuki
authors: H
authors: Koshino
authors: Yayoi
authors: Y
authors: Hongo
authors: Nobuhiro
authors: N
authors: Kanomata
authors: Shunya
authors: S
authors: Takahashi