title: Neuroprotective bakkenolides from the roots of Valeriana jatamansi.
abstract: Two new bakkenolides, valerilactones A (1), and B (2), and two known analogues, bakkenolide-H (3) and bakkenolide-B (4), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. Compounds 1, 2, and 3 exhibited potent neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.
authors: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
authors: Jing
authors: J
authors: Xu
authors: Bo
authors: B
authors: Yang
authors: Yuanqiang
authors: Y
authors: Guo
authors: Da-qing
authors: DQ
authors: Jin
authors: Ping
authors: P
authors: Guo
authors: Cuizhou
authors: C
authors: Liu
authors: Wenbin
authors: W
authors: Hou
authors: Tiejun
authors: T
authors: Zhang
authors: Liping
authors: L
authors: Gui
authors: Zhanping
authors: Z
authors: Sun