title: Computational design of virus-like protein assemblies on carbon nanotube surfaces.
abstract: There is a general need for the engineering of protein-like molecules that organize into geometrically specific superstructures on molecular surfaces, directing further functionalization to create richly textured, multilayered assemblies. Here we describe a computational approach whereby the surface properties and symmetry of a targeted surface define the sequence and superstructure of surface-organizing peptides. Computational design proceeds in a series of steps that encode both surface recognition and favorable intersubunit packing interactions. This procedure is exemplified in the design of peptides that assemble into a tubular structure surrounding single-walled carbon nanotubes (SWNTs). The geometrically defined, virus-like coating created by these peptides converts the smooth surfaces of SWNTs into highly textured assemblies with long-scale order, capable of directing the assembly of gold nanoparticles into helical arrays along the SWNT axis.
authors: Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors: Gevorg
authors: G
authors: Grigoryan
authors: Yong Ho
authors: YH
authors: Kim
authors: Rudresh
authors: R
authors: Acharya
authors: Kevin
authors: K
authors: Axelrod
authors: Rishabh M
authors: RM
authors: Jain
authors: Lauren
authors: L
authors: Willis
authors: Marija
authors: M
authors: Drndic
authors: James M
authors: JM
authors: Kikkawa
authors: William F
authors: WF
authors: DeGrado
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