title: Decision-oriented multi-outcome modeling for anesthesia patients.
abstract: Anesthesia drugs have impact on multiple outcomes of an anesthesia patient. Most typical outcomes include anesthesia depth, blood pressures, heart rates, etc. Traditional diagnosis and control in anesthesia focus on a one-drug-one-outcome scenario. This paper studies the problem of real-time modeling for monitoring, diagnosing, and predicting multiple outcomes of anesthesia patients. It is shown that consideration of multiple outcomes is necessary and beneficial for anesthesia managements. Due to limited real-time data, real-time modeling in multi-outcome modeling requires low-complexity model strucrtures. This paper introduces a method of decision-oriented modeling that significantly reduces the complexity of the problem. The method employs simplified and combined model functions in a Wiener structure to contain model complexity. The ideas of drug impact prediction and reachable sets are introduced for utility of the models in diagnosis, outcome prediction, and decision assistance. Clinical data are used to evaluate the effectiveness of the method.
authors: Dept. of Electrical and Computer Engineering, Wayne State University, Detroit, Michigan 48202, USA.
authors: Zhibin
authors: Z
authors: Tan
authors: Romeo
authors: R
authors: Kaddoum
authors: Le Yi
authors: le Y
authors: Wang
authors: Hong
authors: H
authors: Wang
references: IEEE Trans Biomed Eng. 2004 Nov;51(11):1876-87
references: 15536890
references: J Clin Anesth. 2002 Mar;14(2):146-9
references: 11943530
references: IEEE Trans Biomed Eng. 2001 Aug;48(8):874-89
references: 11499525
references: Anesthesiology. 2000 Mar;92(3):727-38
references: 10719952
references: Artif Intell Med. 2005 Nov;35(3):195-206
references: 16019196
references: Conf Proc IEEE Eng Med Biol Soc. 2005;2006:74-7
references: 17282114
references: Anesthesiology. 1999 Aug;91(2):600-1
references: 10443643
references: Artif Intell Med. 2005 Nov;35(3):207-13
references: 16011892
references: Anesthesiology. 1997 Oct;87(4):808-15
references: 9357882