title: Toward effective vaccine deployment: a systematic study.
abstract: Vaccination is a commonly-used epidemic control strategy based on direct antiviral immunization and indirect reduction of virus transmissibility. There exist three factors related to the efficacy of vaccine deployment; they are: (1) vaccine coverage, (2) releasing time, and (3) deployment method. Yet, the exact impacts of these factors still remain to be systematically studied. In our work, we examine the effectiveness of vaccination-based epidemic control in adjusting the composition of susceptible and infectious individuals (referred to as composite structure) in a host population. We develop a modified compartmental infection model for characterizing virus spreading dynamics in several age-specific host populations (one host population for each age group). We consider vaccine deployment schedules that correspond to different settings of the three deployment factors. Based on our simulation-based experiments, we evaluate the impacts of deployment factors on virus spreading dynamics as well as their implications for an effective vaccination strategy.
authors: Department of Computer Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong. jiming@comp.hkbu.edu.hk
authors: Jiming
authors: J
authors: Liu
authors: Shang
authors: S
authors: Xia
references: CMAJ. 2010 Feb 9;182(2):131-6
references: 19959592
references: Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Jul;66(1 Pt 2):016128
references: 12241447
references: Lancet. 2010 Mar 27;375(9720):1100-8
references: 20096450
references: PLoS One. 2008;3(12):e4005
references: 19104659
references: Nature. 2004 May 13;429(6988):180-4
references: 15141212
references: Epidemiology. 2010 Nov;21(6):842-6
references: 20805752
references: Clin Infect Dis. 2010 Nov 15;51(10):1184-91
references: 20964521
references: PLoS One. 2010 Nov 11;5(11):e13767
references: 21085686
references: Science. 2009 Sep 25;325(5948):1705-8
references: 19696313
references: Pediatr Infect Dis J. 2007 Feb;26(2):97-106
references: 17259870
references: Math Biosci. 2002 Nov-Dec;180:29-48
references: 12387915
references: Science. 2001 May 18;292(5520):1316-7
references: 11360990
references: Nature. 2008 Apr 10;452(7188):750-4
references: 18401408
references: PLoS Med. 2008 Mar 25;5(3):e74
references: 18366252
references: J Math Biol. 1990;28(4):365-82
references: 2117040
references: PLoS Curr. 2009 Dec 09;1:RRN1134
references: 20033093
references: Nat Rev Microbiol. 2008 Jun;6(6):477-87
references: 18533288