title: Dietary patterns in Alzheimer's disease and cognitive aging.
abstract: Much of the attention on diet and Alzheimer's disease (AD) or cognition among the elderly has focused on the role of single nutrients or foods, while available information on dietary pattern (DP) analysis, which better reflects the complexity of the diet, is sparse. In this review, we describe different patterning approaches and present studies performed to date that have assessed the associations between DPs and risk of AD or cognitive function in the elderly. Three patterning approaches have been most commonly used: (i) hypothesis-based that use dietary quality indexes or scores (e.g. Mediterranean pattern), (ii) data-driven that use factor or cluster analysis to derive DPs, (iii) reduced rank regression which combines characteristics of the former two approaches. Despite differences existing among the approaches, DPs characterized by higher intake of fruits, vegetables, fish, nuts and legumes, and lower intake of meats, high fat dairy, and sweets seemed to be associated with lower odds of cognitive deficits or reduced risk of AD. Overall, the inherent advantages as well as the existing evidence of DP analyses strongly suggest that this approach may be valuable in AD and aging research. Further studies are warranted, though, to confirm the findings in different population settings, to address some methodological issues, and possibly utilize the information for future clinical trial design.
authors: The Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA.
authors: Y
authors: Y
authors: Gu
authors: N
authors: N
authors: Scarmeas
references: Am J Clin Nutr. 2002 Oct;76(4):889-96
references: 12324305
references: Br J Nutr. 2001 Feb;85(2):219-25
references: 11242490
references: Am J Hypertens. 2007 Mar;20(3):225-32
references: 17324731
references: Cancer Causes Control. 2000 Dec;11(10):965-74
references: 11142531
references: BMJ. 1997 Jul 5;315(7099):13-7
references: 9233319
references: JAMA. 2009 Aug 12;302(6):638-48
references: 19671905
references: Clin Interv Aging. 2008;3(1):97-109
references: 18494169
references: Int J Epidemiol. 2002 Aug;31(4):847-54
references: 12177033
references: Br J Nutr. 2001 Feb;85(2):133-4
references: 11242479
references: BMJ. 1995 Dec 2;311(7018):1457-60
references: 8520331
references: Eur J Clin Nutr. 1998 Nov;52(11):826-31
references: 9846596
references: Am J Public Health. 2005;95 Suppl 1:S144-50
references: 16030331
references: Am J Clin Nutr. 2009 May;89(5):1543S-1548S
references: 19279083
references: N Engl J Med. 2003 Jun 26;348(26):2599-608
references: 12826634
references: J Am Diet Assoc. 2008 Sep;108(9):1461-71
references: 18755318
references: Arch Intern Med. 2008 Apr 14;168(7):713-20
references: 18413553
references: Am J Epidemiol. 2004 May 15;159(10):935-44
references: 15128605
references: J Am Diet Assoc. 1994 Jan;94(1):57-64
references: 8270756
references: Eur J Clin Nutr. 2009 Nov;63 Suppl 4:S263-74
references: 19888278
references: Arch Neurol. 2009 Feb;66(2):216-25
references: 19204158
references: Maturitas. 2009 Jan 20;62(1):1-8
references: 19128905
references: Am J Clin Nutr. 1999 Feb;69(2):243-9
references: 9989687
references: Eur J Clin Nutr. 2001 Dec;55(12):1053-8
references: 11781671
references: Lancet Neurol. 2004 Oct;3(10):579-87
references: 15380154
references: J Nutr. 2006 Mar;136(3):626-33
references: 16484535
references: BMJ. 2008 Sep 11;337:a1344
references: 18786971
references: Eur J Clin Nutr. 2007 Feb;61(2):270-8
references: 16929244
references: Arch Neurol. 2010 Jun;67(6):699-706
references: 20385883
references: Am J Clin Nutr. 2005 Sep;82(3):675-84; quiz 714-5
references: 16155283
references: Neurology. 2007 Nov 13;69(20):1921-30
references: 17998483
references: JAMA. 2009 Aug 12;302(6):627-37
references: 19671904
references: Br J Nutr. 2009 Jul;101 Suppl 2:S12-20
references: 19594960
references: Br J Nutr. 2006 May;95(5):860-9
references: 16611375
references: Public Health Nutr. 2009 Sep;12(9A):1607-17
references: 19689829
references: Neurology. 2007 Jan 30;68(5):326-37
references: 17261678
references: Curr Opin Lipidol. 2002 Feb;13(1):3-9
references: 11790957
references: N Engl J Med. 1997 Apr 17;336(16):1117-24
references: 9099655
references: J Nutr. 2004 Jun;134(6):1541-5
references: 15173426
references: Public Health Nutr. 2008 Oct;11(10):1054-62
references: 18205988
references: J Am Diet Assoc. 1995 Oct;95(10):1103-8
references: 7560680
references: Ann Neurol. 2006 Jun;59(6):912-21
references: 16622828
references: J Nutr. 2009 Oct;139(10):1944-9
references: 19675102
references: Am J Clin Nutr. 2002 Dec;76(6):1261-71
references: 12450892
references: Hypertension. 2010 Jun;55(6):1331-8
references: 20305128
references: J Am Diet Assoc. 2009 Jun;109(6):1022-30
references: 19465184
references: JAMA. 2000 Apr 26;283(16):2109-15
references: 10791502
references: J Am Diet Assoc. 2004 Apr;104(4):615-35
references: 15054348
references: J Am Diet Assoc. 2008 Nov;108(11):1896-901
references: 18954580
references: Am J Clin Nutr. 2009 Oct;90(4):1075-83
references: 19710193
references: Am J Epidemiol. 1998 Jul 1;148(1):17-9
references: 9663398
references: Dement Geriatr Cogn Disord. 2009;27(2):147-54
references: 19182482
references: World Health Organ Tech Rep Ser. 1990;797:1-204
references: 2124402
references: Comput Methods Programs Biomed. 2006 Jul;83(1):73-7
references: 16806570
references: Arch Neurol. 2006 Dec;63(12):1709-17
references: 17030648
references: Epidemiol Rev. 2008;30:35-66
references: 18779228