title: Basiliximab induction and delayed calcineurin inhibitor initiation in liver transplant recipients with renal insufficiency.
abstract: BACKGROUND
  Renal insufficiency (RI) is common after liver transplantation (LT) and may worsen due to calcineurin inhibitor (CNI) use. We compared LT outcomes using basiliximab induction and delayed CNI initiation to controls with a standard CNI regimen in patients with peri-LT RI.
  
  
  METHODS
  All adults transplanted January 2004 to December 2007 with peri-LT RI (hemodialysis or creatinine ≥1.5 within 1 week of LT) were included in a retrospective nonrandomized cohort. Outcomes including 30-day and 1-year patient and graft survival and renal function were compared between basiliximab and control groups.
  
  
  RESULTS
  Two hundred twenty-nine patients (102 basiliximab, 127 controls) were analyzed, mean age 54 years, 72% men, 54% with hepatitis C virus. Mean model for end-stage liver disease (28.2 vs. 20.0; P<0.001) and creatinine (1.9 vs. 1.6; P=0.001) were higher and more patients were on hemodialysis at LT (29% vs. 6%; P<0.001) in the basiliximab group. 30-day patient (99% vs. 97%; P=0.26) and graft survival (98% vs. 95%; P=0.17), 1-year patient (87% vs. 87%; P=0.89) and graft survival (86% vs. 82%; P=0.37), mean creatinine at 1-year (1.5 vs. 1.5 mg/dL; P=0.82), and treated acute rejection (6% vs. 6%; P=0.90) were similar between basiliximab and control groups, respectively. In multivariable logistic regression, basiliximab was not significantly associated with 30-day (odds ratio, 0.10; P=0.11) or 1-year (odds ratio, 0.97; P=0.94) survival, controlling for age, previous LT, model for end-stage liver disease, and hepatitis C virus.
  
  
  CONCLUSIONS
  Basiliximab induction resulted in 30-day and 1-year patient, graft and renal outcomes comparable with a control group receiving standard CNI-based immunosuppression. Antibody induction with delayed CNI should be further studied prospectively.
authors: Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, New York, NY 10032-3784, USA.
authors: Elizabeth C
authors: EC
authors: Verna
authors: Erica D
authors: ED
authors: Farrand
authors: Abdulrhman S
authors: AS
authors: Elnaggar
authors: Elsa M
authors: EM
authors: Pichardo
authors: Anastasia
authors: A
authors: Balducci
authors: Jean C
authors: JC
authors: Emond
authors: James V
authors: JV
authors: Guarrera
authors: Robert S
authors: RS
authors: Brown