title: Preoperative superselective intraarterial chemotherapy in the combined treatment of gastric-carcinoma.
abstract: 146 patients were included in this prospective, randomized study: 50 patients were treated with surgery alone (S), 49 patients received pre-operative intravenous (systemic) chemotherapy (IVCH) and 47 patients received pre-operative superselective intra-arterial chemotherapy (IACH). Left gastric and right gastroepiploic arteries were catheterized for IACH. After IACH a measurable tumor response was registered in 87.1% of the patients; in 61.6% no residual tumor was found in the resected stomach. IVCH produced no survival benefit compared to surgery alone. IACH plus S improved 3-year survival relative to surgery alone (89.3+/-2.1% vs 35.5+/-4.9%; p<0.01). Projected 5-year survival in the IACH+S group is 78.1% vs. 30.1% with surgery alone (p<0.01). IACH provided substantial survival benefit when used as a component of combined modality gastric cancer treatment.
authors: UKRAINIAN INST ONCOL & RADIOL,KIEV,UKRAINE.
authors: I
authors: I
authors: Shchepotin
authors: S
authors: S
authors: Evans
authors: V
authors: V
authors: Chorny
authors: O
authors: O
authors: Ugrinov
authors: S
authors: S
authors: Osinsky
authors: K
authors: K
authors: Galakchin
authors: I
authors: I
authors: Troitsky
authors: R
authors: R
authors: Buras
authors: M
authors: M
authors: Shabahang
authors: R
authors: R
authors: Nauta