title: Initial results after implementation of a multimodal treatment for peritoneal malignancies.
abstract: BACKGROUND
  Peritoneal carcinomatosis represents a clinical condition with a limited perspective concerning long term survival. The combination of surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) represents a complex multimodal therapeutic management concept with promising results for prolongation of survival. For the identification of pitfalls during implementation of the HIPEC procedure into clinical practice an observational study was conducted.
  
  
  METHODS
  Between 2005 and 2009 data from all patients treated with cytoreductive surgery and HIPEC for peritoneal carcinomatosis was prospectively collected and analysed.
  
  
  RESULTS
  During the observational interval a total of 42 patients underwent surgical treatment for peritoneal carcinomatosis. In 34 patients the complete procedure with surgical cytoreduction and HIPEC was performed. Perioperative mortality (6%) and morbidity (35%) was similar to other reported series. Twenty-five patients (76%) survived the 18 months follow-up period after complete procedure.
  
  
  CONCLUSIONS
  The multimodal therapeutic treatment concept of surgical cytoreduction and following HIPEC leads to promising results for patients suffering from peritoneal carcinomatosis. However this treatment concept is afflicted with a relevant risk of postoperative complications.
authors: Department of General-, Visceral-, Vascular and Thoracic Surgery, Charité - University Medicine Berlin, Campus Mitte, Berlin, Germany. wieland.raue@charite.de
authors: W
authors: W
authors: Raue
authors: N
authors: N
authors: Tsilimparis
authors: C
authors: C
authors: Langelotz
authors: B
authors: B
authors: Rau
authors: W
authors: W
authors: Schwenk
authors: J
authors: J
authors: Hartmann