title: Improved myo-inositol detection through Carr-Purcell PRESS: a tool for more sensitive mild cognitive impairment diagnosis.
abstract: A 3-T study is presented, comparing the ability of two (1) H spectroscopy pulse sequences, Carr-Purcell point resolved spectroscopy (CPRESS; TE = 45 msec), and conventional PRESS (TE = 35 msec), to separate between groups of 20 normal control (NC) and 20 mild cognitive impairment (MCI) subjects. Both sequences showed higher myo-inositol (mI) and mI/N-acetyl-aspartate (NAA) levels in the posterior cingulate gyrus of the MCI subjects. The increased intrasubject repeatability of mI and mI/NAA CPRESS measurements (∼ 6% vs. 9% for PRESS) translated into decreased intraclass variability. A 22% intraclass mI PRESS variability was reduced to 16% for CPRESS, and an 18% intraclass mI/NAA PRESS variability was reduced to 12% for CPRESS for the group of NC subjects. Similar results were observed for the MCI subjects. Decreased intraclass variability led to improved separation between NC and MCI subjects (P = 0.017 for PRESS and P < 0.0001 for CPRESS mI/NAA, the best NC/MCI discriminant for each method). Seventy-five percent sensitivity at eighty percent specificity was demonstrated by mI/NAA CPRESS measurements in separating NC from MCI subjects. High correlations were also observed between subject performance on a number of neuropsychological tests (probing verbal memory, visuoconstruction performance, and visual motor integration) and the mI/NAA ratio; higher correlation coefficients (with stronger statistical significance) were consistently evident for CPRESS than for PRESS data.
authors: GE Global Research Center, Niskayuna, New York 12309, USA. hancu@ge.com
authors: Ileana
authors: I
authors: Hancu
authors: Robert
authors: R
authors: Gillen
authors: John
authors: J
authors: Cowan
authors: Earl A
authors: EA
authors: Zimmerman
references: J Magn Reson Imaging. 2003 Jun;17(6):625-33
references: 12766890
references: Arch Neurol. 1999 Mar;56(3):303-8
references: 10190820
references: NMR Biomed. 2009 May;22(4):426-35
references: 19006101
references: NMR Biomed. 1991 Apr;4(2):59-63
references: 1677586
references: Neurobiol Aging. 2004 Mar;25(3):303-10
references: 15123335
references: Magn Reson Med. 1993 Dec;30(6):672-9
references: 8139448
references: J Psychiatr Res. 1982-1983;17(1):37-49
references: 7183759
references: Neuroimaging Clin N Am. 1998 Nov;8(4):809-22
references: 9769343
references: Neurology. 2000 Jul 25;55(2):210-7
references: 10908893
references: Arch Neurol. 2001 Mar;58(3):397-405
references: 11255443
references: Brain Res. 2004 Apr 2;1003(1-2):26-35
references: 15019560
references: Neurology. 1993 Nov;43(11):2412-4
references: 8232972
references: J Magn Reson Imaging. 2009 Nov;30(5):1155-62
references: 19856449
references: Magn Reson Med. 1997 Jun;37(6):816-20
references: 9178230
references: NMR Biomed. 2000 May;13(3):129-53
references: 10861994
references: Neurobiol Aging. 2004 Aug;25(7):913-24
references: 15212845
references: Dev Neurosci. 1993;15(3-5):289-98
references: 7805581
references: NMR Biomed. 2007 Aug;20(5):512-21
references: 17205487
references: J Int Neuropsychol Soc. 2009 May;15(3):372-82
references: 19402923
references: Dement Geriatr Cogn Disord. 2002;14(4):198-207
references: 12411762
references: Dement Geriatr Cogn Disord. 2006;22(2):165-72
references: 16847376
references: Neurology. 2002 Mar 12;58(5):758-64
references: 11889240
references: Magn Reson Imaging. 2004 Dec;22(10):1385-93
references: 15707788
references: Neuroreport. 2001 Aug 8;12(11):2315-7
references: 11496102