title: The formation of lipid droplets: possible role in the development of insulin resistance/type 2 diabetes.
abstract: Neutral lipids are stored in so-called lipid droplets, which are formed as small primordial droplets at microsomal membranes and increase in size by a fusion process. The fusion is catalyzed by the SNARE proteins SNAP23, syntaxin-5 and VAMP4. SNAP23 is involved in the insulin dependent translocation of GLUT4 to the plasma membrane, and has an important role in the development of insulin resistance. Thus fatty acids relocalize SNAP23 from the plasma membrane (and the translocation of GLUT 4) to the interior of the cell giving rise to insulin resistance. Moreover this relocalization is seen in skeletal muscles biopsies from patients with type 2 diabetes compared to matched control. Thus a missorting of SNAP23 is essential for the development of insulin resistance.
authors: Sahlgrenska Center for Metabolic and Cardiovascular Research, the Department of Molecular and Clinical Medicine, Sahlgenska Academy University of Göteborg, Sweden. Sven-Olof.Olofsson@wlab.gu.se
authors: Sven-Olof
authors: SO
authors: Olofsson
authors: Linda
authors: L
authors: Andersson
authors: Liliana
authors: L
authors: Håversen
authors: Christina
authors: C
authors: Olsson
authors: Susanna
authors: S
authors: Myhre
authors: Mikael
authors: M
authors: Rutberg
authors: Reza
authors: R
authors: Mobini
authors: Lu
authors: L
authors: Li
authors: Emma
authors: E
authors: Lu
authors: Jan
authors: J
authors: Borén
authors: Pontus
authors: P
authors: Boström