title: Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K.
abstract: Vitamin K(2) has been demonstrated to induce gene expression related to bone formation through a nuclear steroid and xenobiotic receptor (SXR). We synthesized new vitamin K analogues with the same isoprene side chains symmetrically introduced at the 2 and 3 positions of 1,4-naphthoquinone and evaluated the transcriptional activity of the target gene. The transcriptional activity was related to the length of the side chain which allowed optimal interaction with ligand-binding domain of SXR.
authors: Laboratory of Environmental Sciences, Yokohama College of Pharmacy, Totsuka-ku, Yokohama, Japan.
authors: Yoshitomo
authors: Y
authors: Suhara
authors: Masato
authors: M
authors: Watanabe
authors: Sayaka
authors: S
authors: Motoyoshi
authors: Kimie
authors: K
authors: Nakagawa
authors: Akimori
authors: A
authors: Wada
authors: Kazuyoshi
authors: K
authors: Takeda
authors: Kazuhiko
authors: K
authors: Takahashi
authors: Hiroaki
authors: H
authors: Tokiwa
authors: Toshio
authors: T
authors: Okano