title: Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase.
abstract: An inhibitor of poly (ADP-ribose) polymerase, 1,5-dihydroxyisoquinoline (DHIQ), evaluated in vivo against a murine advanced breast cancer, significantly improved by 20% the PR rate of tumor-regressing chemotherapy. A detailed sequential biochemical cascade is proposed for chemotherapy-induced apoptosis, and the rationale for the utilization of the inhibitor is explained.
authors: CATHOLIC MED CTR, DEPT CANC RES, NEW YORK, NY 11421 USA.
authors: D
authors: D
authors: Martin
authors: R
authors: R
authors: Stolfi
authors: L
authors: L
authors: Nord
authors: J
authors: J
authors: Colofiore