title: [The expression of VCAM-1 in organs of rats died of anaphylactic shock].
abstract: OBJECTIVE
  To investigate the effect and expression of the vascular cell adhesion molecule-1 (VCAM-1) in organs of rats died of anaphylactic shock.
  
  
  METHODS
  The models of anaphylactic shock in rats were made and the immunohistochemistry of SABC was used to detect as follows: (1) The expression of VCAM-1 in rat lung, heart, brain, kidney, liver, spleen, stomach and intestine. (2) VCAM-1 levels in lungs at 10 min, 30 min after the allergic shock, and the time of death. (3) VCAM-1 levels in lungs of rats after the intervention of anti-VCAM-1.
  
  
  RESULTS
  After the death, the expression VCAM-1 in lungs increased significantly relative to the control group and followed the extension of shock. In the rats which were injected with the anti-VCAM-1, the expression of VCAM-1 in lungs reduced.
  
  
  CONCLUSIONS
  (1) The expression of VCAM-1 shows difference in the various organs of rats after anaphylactic shock. The change of VCAM-1 is the most obvious in lungs and would increase followed the extension of anaphylactic shock. (2) After the anaphylactic shock, anti-VCAM-1 can inhibit the expression of VCAM-1 in rat lung.
authors: School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China.
authors: Xiao-jie
authors: XJ
authors: Li
authors: Xiang-jie
authors: XJ
authors: Guo
authors: Cai-rong
authors: CR
authors: Gao