title: Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome.
abstract: The pathogenesis of irritable bowel syndrome (IBS) is considered to be multifactorial and includes psychosocial factors, visceral hypersensitivity, infection, microbiota and immune activation. It is becoming increasingly clear that low-grade inflammation is present in IBS patients and a number of biomarkers have emerged. This review describes the evidence for low-grade inflammation in IBS and explores its mechanism with particular focus on gastrointestinal motor dysfunction. Understanding of the immunological basis of the altered gastrointestinal motor function in IBS may lead to new therapeutic strategies for IBS.
authors: Hirotada Akiho, Eikichi Ihara, Kazuhiko Nakamura, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors: Hirotada
authors: H
authors: Akiho
authors: Eikichi
authors: E
authors: Ihara
authors: Kazuhiko
authors: K
authors: Nakamura
references: Gut. 2002 Jul;51 Suppl 1:i19-23
references: 12077058
references: Curr Gastroenterol Rep. 2008 Aug;10(4):385-90
references: 18627650
references: Gastroenterology. 2005 Nov;129(5):1557-66
references: 16285955
references: Gastroenterology. 2007 Jan;132(1):397-414
references: 17241888
references: Mediators Inflamm. 2009;2009:517052
references: 20016839
references: J Physiol. 1998 May 1;508 ( Pt 3):871-81
references: 9518739
references: Neurogastroenterol Motil. 2003 Feb;15(1):79-86
references: 12588472
references: Clin Gastroenterol Hepatol. 2009 Jan;7(1):48-53
references: 18848909
references: J Cell Sci. 1985 Feb;73:187-206
references: 4019592
references: Am J Gastroenterol. 2000 Dec;95(12):3503-6
references: 11151884
references: Digestion. 2001;63(3):188-94
references: 11351146
references: Gastroenterology. 2002 Dec;123(6):1972-9
references: 12454854
references: J Muscle Res Cell Motil. 1998 May;19(4):325-41
references: 9635276
references: Am J Physiol Gastrointest Liver Physiol. 2003 Sep;285(3):G483-93
references: 12646416
references: Drugs. 2001;61(3):317-32
references: 11293643
references: Gastroenterology. 2004 Mar;126(3):693-702
references: 14988823
references: World J Gastroenterol. 2007 Mar 7;13(9):1313-32
references: 17457962
references: Trends Mol Med. 2009 Oct;15(10):478-89
references: 19811951
references: Clin Exp Immunol. 2006 Mar;143(3):389-97
references: 16487236
references: Biochem J. 2002 Jul 1;365(Pt 1):79-87
references: 11931630
references: Dig Dis Sci. 1993 Sep;38(9):1590-5
references: 8359068
references: Aliment Pharmacol Ther. 2010 Jan;31(1):35-46
references: 19785622
references: Science. 1996 Jul 12;273(5272):245-8
references: 8662509
references: Curr Gastroenterol Rep. 2008 Aug;10(4):363-8
references: 18627647
references: Gastroenterology. 2004 Jan;126(1):159-69
references: 14699497
references: Physiol Rev. 2003 Oct;83(4):1325-58
references: 14506307
references: Clin Gastroenterol Hepatol. 2008 Feb;6(2):194-205
references: 18237869
references: Am J Physiol Gastrointest Liver Physiol. 2005 Mar;288(3):G422-30
references: 15701621
references: Scand J Gastroenterol. 2008;43(12):1467-76
references: 18752146
references: Gastroenterology. 2005 Mar;128(3):783-5
references: 15765414
references: Mol Pharmacol. 2009 May;75(5):1031-41
references: 19190174
references: Trop Gastroenterol. 2009 Apr-Jun;30(2):76-85
references: 19760989
references: Infect Immun. 2001 Feb;69(2):838-44
references: 11159976
references: Neurogastroenterol Motil. 2009 Nov;21(11):1189-e107
references: 19413681
references: Neurogastroenterol Motil. 2010 May;22(5):573-8, e124
references: 20003079
references: Pain. 2010 Jun;149(3):555-564
references: 20413219
references: Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G226-32
references: 11804843
references: Pharmacol Ther. 1994 Apr-May;62(1-2):159-73
references: 7991641
references: Gut. 2000 Dec;47(6):804-11
references: 11076879
references: Lancet. 2000 Mar 25;355(9209):1035-40
references: 10744088
references: Aliment Pharmacol Ther. 1997 Dec;11(6):1109-14
references: 9663837
references: Gastroenterology. 2002 Jun;122(7):1778-83
references: 12055584
references: Gastroenterology. 2006 Feb;130(2):304-11
references: 16472586
references: Gastroenterology. 2007 Mar;132(3):913-20
references: 17383420
references: Am J Gastroenterol. 2000 May;95(5):1231-8
references: 10811333
references: Nature. 2003 Feb 13;421(6924):744-8
references: 12610626
references: FEBS Lett. 2001 Mar 30;493(2-3):91-4
references: 11287002
references: Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G250-5
references: 17431212
references: Neuropharmacology. 1999 Aug;38(8):1083-152
references: 10462127
references: J Gastroenterol. 2007 Jan;42 Suppl 17:29-33
references: 17238023
references: Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1429-38
references: 17307724
references: Dig Dis Sci. 2008 Jan;53(1):169-74
references: 17520365
references: Arch Intern Med. 2001 Jul 23;161(14):1733-40
references: 11485506
references: Neuropharmacology. 2008 Nov;55(6):1072-80
references: 18687345
references: Neurogastroenterol Motil. 2000 Oct;12(5):449-57
references: 11012945
references: Gut. 2002 Aug;51(2):155-63
references: 12117872
references: Neurogastroenterol Motil. 2006 Jul;18(7):578-88
references: 16771773
references: Gastroenterology. 2005 Jul;129(1):131-41
references: 16012943
references: Biochem J. 2002 Oct 15;367(Pt 2):517-24
references: 12144526
references: Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G699-710
references: 17656444
references: Gastroenterology. 2002 Nov;123(5):1554-64
references: 12404230
references: Front Biosci (Landmark Ed). 2009 Jan 01;14:2765-78
references: 19273235
references: J Immunol. 2006 Jul 1;177(1):566-73
references: 16785554
references: J Gastroenterol Hepatol. 2010 Feb;25(2):244-51
references: 20074148
references: Gut. 2008 Apr;57(4):475-81
references: 18198200
references: Aliment Pharmacol Ther. 2009 Apr 15;29(8):834-42
references: 19226291
references: Gastroenterology. 2003 May;124(6):1662-71
references: 12761724
references: J Physiol. 2003 Mar 1;547(Pt 2):531-42
references: 12562962
references: Int Rev Immunol. 2002 Jul-Oct;21(4-5):439-67
references: 12486823
references: Gastroenterology. 2004 Aug;127(2):635-57
references: 15300595
references: Clin Chim Acta. 2009 May;403(1-2):47-55
references: 19361459
references: Am J Gastroenterol. 2009 Jul;104(7):1831-43; quiz 1844
references: 19471254
references: Am J Physiol Gastrointest Liver Physiol. 2004 Nov;287(5):G954-61
references: 15231486
references: Aliment Pharmacol Ther. 2001 Jul;15(7):959-64
references: 11421870
references: Aliment Pharmacol Ther. 2004 Jul;20 Suppl 2:1-9
references: 15335408
references: Gastroenterology. 2006 Apr;130(5):1480-91
references: 16678561
references: Neurogastroenterol Motil. 2008 Oct;20(10):1147-56
references: 18761632
references: J Immunol. 2003 Jul 15;171(2):948-54
references: 12847266
references: Gut. 2009 Dec;58(12):1571-5
references: 19923339
references: Pharmacoeconomics. 2001;19(6):643-53
references: 11456212
references: Am J Physiol. 1991 Dec;261(6 Pt 1):G1017-23
references: 1767843
references: Gastroenterology. 2006 Jan;130(1):34-43
references: 16401466
references: Am J Gastroenterol. 2009 Jan;104 Suppl 1:S1-35
references: 19521341
references: Neurogastroenterol Motil. 2008 Aug;20(8):900-7
references: 18363639
references: Gastroenterology. 2008 Jul;135(1):217-225.e1
references: 18471439
references: Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G102-10
references: 11408260
references: Gastroenterology. 2007 Jan;132(1):26-37
references: 17241857
references: Annu Rev Immunol. 2009;27:485-517
references: 19132915
references: Dig Liver Dis. 2009 Dec;41(12):850-3
references: 19740713
references: Annu Rev Immunol. 1989;7:145-73
references: 2523712
references: Gastroenterology. 2002 Aug;123(2):425-32
references: 12145795
references: Am J Gastroenterol. 2005 Feb;100(2):373-82
references: 15667495
references: Am J Physiol Gastrointest Liver Physiol. 2000 Feb;278(2):G259-65
references: 10666050
references: J Appl Bacteriol. 1991 Jun;70(6):443-59
references: 1938669
references: Gut. 2008 Dec;57(12):1682-9
references: 18653729
references: J Immunol. 2003 Dec 1;171(11):6173-7
references: 14634133
references: Curr Opin Investig Drugs. 2004 Jan;5(1):55-60
references: 14983974
references: Gastroenterology. 2004 Jun;126(7):1657-64
references: 15188158
references: Adv Ther. 2009 May;26(5):519-30
references: 19444393
references: Neurogastroenterol Motil. 2010 Feb;22(2):e69-76
references: 19740115
references: Gastroenterology. 2003 Dec;125(6):1651-9
references: 14724817
references: J Immunol. 2007 Apr 1;178(7):4641-9
references: 17372023
references: Clin Gastroenterol Hepatol. 2005 Apr;3(4):349-57
references: 15822040
references: J Biol Chem. 2003 Dec 5;278(49):48794-804
references: 14512413
references: Gastroenterology. 1996 Dec;111(6):1683-99
references: 8942751
references: Gastroenterology. 2002 Dec;123(6):2108-31
references: 12454866
references: Neurogastroenterol Motil. 2007 Aug;19 Suppl 2:25-31
references: 17620085