title: Pulmonary vein variants predispose to atrial fibrillation: a case-control study using multislice contrast-enhanced computed tomography.
abstract: OBJECTIVE
  Pulmonary veins (PV) play a pivotal role in atrial fibrillation (AF). Anatomical variants of PV have been described and related to a higher arrhythmogenic potential. The aim of this study was to compare the prevalence of PV variants and diameters of PV ostia in AF patients and controls.
  
  
  RESULTS
  Variants of PV were defined as right or left common ostia (RCO, LCO), a right middle or right top PV . A long common trunk (LCT) was defined as an LCO with a distance to the first branching ≥ 10 mm. Multislice contrast-enhanced thoracic computed tomography was performed prior to AF ablation in 166 consecutive patients, 47.6% with paroxysmal, 52.4% with persistent AF, as well as in a sex- and age-matched control group without AF, for non-cardiological indications. Images were evaluated by two independent observers. The mean age was 59 ± 10 years, 108 were men (65.1%). A higher prevalence of LCO was found in the AF group: 33.7 vs. 19.9% (P= 0.004), odds ratio (OR) 2.1; 15.4% in patients vs. 10.2% in controls had an LCT (P= 0.14). No differences in other PV variants were found. The ostial diameters were greater in AF-patients (P< 0.001).
  
  
  CONCLUSIONS
  To the best of our knowledge, the present study shows for the first time a higher prevalence of an LCO in patients with AF as compared with controls, with an OR of 2.1. This suggests a pre-disposing role of LCO in the development of AF.
authors: Department of Cardiology and Angiology, Division of Experimental and Clinical Electrophysiology, Hospital of University of Münster, Germany.
authors: Alex
authors: A
authors: Bittner
authors: Gerold
authors: G
authors: Mönnig
authors: Ann Janine
authors: AJ
authors: Vagt
authors: Stephan
authors: S
authors: Zellerhoff
authors: Kristina
authors: K
authors: Wasmer
authors: Julia
authors: J
authors: Köbe
authors: Christian
authors: C
authors: Pott
authors: Peter
authors: P
authors: Milberg
authors: Cristina
authors: C
authors: Sauerland
authors: Johannes
authors: J
authors: Wessling
authors: Lars
authors: L
authors: Eckardt