title: Frequency and clinical correlates of radiographic patterns of bronchopulmonary dysplasia in very low birth weight infants by term age.
abstract: Our aim was to study the frequency and clinical correlates of two radiographic patterns of bronchopulmonary dysplasia (BPD), the cystic BPD (cBPD) and the leaky lung syndrome (LLS). Radiographic findings of BPD from sixth day of life until term in a cohort of 82 very low birth weight (VLBW) infants were evaluated and scored independently by a neonatologist and a paediatric radiologist. Data on prenatal factors and events during the first hospitalisation were collected prospectively. Forty-four (53.7%) infants showed radiographic evidence of BPD, 19 (23.2%) cBPD and 25 (30.5%) LLS. In multivariate analysis, the best predictors for radiographic BPD were oxygen dependency at 28 days (odds ratio (OR) 10.2 [95% confidence interval (CI) 2.49-41.4]), more than 2 days on ventilator (OR 10.4 [95% CI 1.8-61.5]) and volume expanders in the first 2 h (OR 7.36 [95% CI 1.32-41.2]). During the first week of life, infants with radiographic BPD received less energy per kilogram (p < 0.001) and more daily fluids per kilogram of body weight (p = 0.013). Sixty-two percent of the infants with radiographic BPD were not oxygen dependent at 36 weeks postmenstrual age (PMA). Seventeen (89.5%) of the 19 infants who needed oxygen supplementation at 36 weeks PMA also had abnormal chest X-rays.
  
  
  CONCLUSIONS
  Radiographic BPD findings appeared to be common in VLBW infants. In addition to the well-known respiratory risk factors (oxygen and ventilator therapy), poor nutrition and excessive fluid administration in early life seem to be significantly associated with radiological findings of lung injury in these patients.
authors: Paediatric Research Centre, University of Tampere, Tampere, Finland.
authors: Elina
authors: E
authors: Hyödynmaa
authors: Päivi
authors: P
authors: Korhonen
authors: Sirkku
authors: S
authors: Ahonen
authors: Tiina
authors: T
authors: Luukkaala
authors: Outi
authors: O
authors: Tammela
references: Pediatrics. 1988 Oct;82(4):527-32
references: 3174313
references: Pediatr Pulmonol. 2001 Apr;31(4):297-300
references: 11288212
references: N Engl J Med. 1967 Feb 16;276(7):357-68
references: 5334613
references: Semin Neonatol. 2003 Feb;8(1):29-38
references: 12667828
references: Pediatr Clin North Am. 1986 Feb;33(1):179-201
references: 3081865
references: Pediatr Radiol. 1996;26(8):508-11
references: 8753660
references: J Pediatr. 1998 Jan;132(1):57-63
references: 9470001
references: Paediatr Respir Rev. 2010 Sep;11(3):158-61
references: 20692630
references: Br J Radiol. 2000 Apr;73(868):366-9
references: 10844861
references: Acta Paediatr. 2004 Feb;93(2):211-5
references: 15046276
references: J Pediatr. 2002 Feb;140(2):171-6
references: 11865267
references: Am J Dis Child. 1984 Jun;138(6):581-5
references: 6720645
references: Duodecim. 1989;105(18):1540-6
references: 2680445
references: Eur J Pediatr. 2004 Jan;163(1):14-8
references: 14610670
references: Arch Dis Child. 1989 Apr;64(4 Spec No):448-51
references: 2730112
references: J Perinatol. 2003 Sep;23(6):451-6
references: 13679930
references: Lancet. 2006 Apr 29;367(9520):1421-31
references: 16650652
references: Pediatr Radiol. 2001 May;31(5):339-42
references: 11373921
references: Lancet. 1993 Jul 24;342(8865):193-8
references: 8100927
references: Pediatrics. 1984 Jul;74(1):127-33
references: 6547526
references: Pediatrics. 2004 Nov;114(5):1305-11
references: 15520112
references: Pediatrics. 2008 Apr;121(4):e936-44
references: 18378548
references: J Pediatr. 1995 Apr;126(4):605-10
references: 7699543
references: Pediatr Radiol. 1986;16(3):180-4
references: 3703591
references: Pediatrics. 1999 Apr;103(4 Pt 1):759-65
references: 10103299