title: The l-Ser analog #290 promotes bone recovery in OP and RA mice.
abstract: We previously characterized the l-Ser analog #290, H(tBut)-l-Ser-O-Methyl·HCl, as a novel inhibitor of osteoclastogenesis which functions in both mouse and human cells. Here, we assessed the activity of #290 in animal models of osteoporosis and rheumatoid arthritis. Treatment of animals with #290 both prevented bone loss and led to the recovery of lost bone in osteoporotic mice. When inflammatory arthritis was induced in SKG mice, #290 treatment suppressed arthritis scores and significantly prevented the destruction of calcaneous bones. Additionally, #290 reciprocally modulated the mammalian target of rapamycin (mTOR) pathway in osteoclasts and osteoblasts in vitro, suggesting a dual effect on bone homeostasis. Our results demonstrate that #290 is a potential novel therapeutic tool for the treatment and/or study of diseases associated with bone destruction.
authors: Graduate School of Biological Sciences, Nara Institute of Science and, Technology, 8916-5 Takayama, Ikoma, Nara 630-0101, Japan.
authors: Anton
authors: A
authors: Bahtiar
authors: Takashi
authors: T
authors: Nakamura
authors: Koichi
authors: K
authors: Kishida
authors: Junpei
authors: J
authors: Katsura
authors: Mai
authors: M
authors: Nitta
authors: Norihiro
authors: N
authors: Ishida-Kitagawa
authors: Takuya
authors: T
authors: Ogawa
authors: Tatsuo
authors: T
authors: Takeya