title: Are pathogenic bacteria just looking for food? Metabolism and microbial pathogenesis.
abstract: It is interesting to speculate that the evolutionary drive for microbes to develop pathogenic characteristics was to access the nutrient resources that animals provided. Animal environments that pathogens colonize have likely driven the evolution of new bacterial characteristics to maximize these new nutritional opportunities. This review focuses on genomic and functional aspects of pathogen metabolism that allow efficient utilization of nutrient resources provided by animals. Similar to genes encoding specific virulence traits, genes encoding metabolic functions have been horizontally acquired by pathogens to provide a selective advantage in host tissues. Selective advantage in host tissues can also be gained by loss of function mutations that alter metabolic capabilities. Greater understanding of bacterial metabolism within host tissues should be important for increased understanding of host-pathogen interactions and the development of future therapeutic strategies.
authors: Department of Immunology, University of Washington, Seattle, WA 98195, USA.
authors: Laurence
authors: L
authors: Rohmer
authors: Didier
authors: D
authors: Hocquet
authors: Samuel I
authors: SI
authors: Miller
references: Br J Dermatol. 2008 Mar;158(3):442-55
references: 18275522
references: Nat Rev Microbiol. 2008 Jan;6(1):53-66
references: 18026123
references: Cochrane Database Syst Rev. 2009 Oct 07;(4):CD004197
references: 19821321
references: Nat Rev Microbiol. 2010 Jan;8(1):15-25
references: 19946288
references: Appl Environ Microbiol. 2010 Jan;76(2):400-5
references: 19948869
references: Cell Host Microbe. 2009 May 8;5(5):476-86
references: 19454351
references: Curr Opin Microbiol. 2010 Feb;13(1):11-7
references: 20034843
references: Annu Rev Microbiol. 2000;54:641-79
references: 11018140
references: Nature. 2001 Oct 25;413(6858):852-6
references: 11677609
references: Proc Natl Acad Sci U S A. 2006 May 30;103(22):8487-92
references: 16687478
references: Gastroenterology. 2009 May;136(6):1863-73
references: 19457415
references: Biometals. 2006 Apr;19(2):173-80
references: 16718602
references: Infect Immun. 2009 Sep;77(9):3807-16
references: 19564383
references: Microbiol Mol Biol Rev. 2009 Jun;73(2):233-48
references: 19487727
references: Int J Med Microbiol. 2011 Jan;301(1):1-6
references: 20705507
references: Nat Rev Microbiol. 2010 Feb;8(2):117-28
references: 20075926
references: PLoS Pathog. 2010 Jan 08;6(1):e1000712
references: 20072604
references: PLoS Pathog. 2010 Aug 12;6(8):e1000949
references: 20711357
references: Mol Microbiol. 2000 Jun;36(5):1015-23
references: 10844687
references: Curr Opin Microbiol. 2009 Apr;12(2):182-91
references: 19249239
references: Nature. 2010 Sep 23;467(7314):426-9
references: 20864996
references: Infect Immun. 2002 Feb;70(2):685-91
references: 11796600
references: Infect Immun. 2011 Jan;79(1):153-66
references: 21041498
references: Infect Immun. 1992 Feb;60(2):406-15
references: 1730470
references: PLoS Pathog. 2009 May;5(5):e1000448
references: 19478872
references: PLoS Biol. 2007 Oct;5(10):2177-89
references: 17760501
references: J Infect Dis. 1994 Dec;170(6):1616-21
references: 7996008
references: Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5502-7
references: 16569701
references: Arch Dis Child. 1998 Jan;78(1):49-53
references: 9534676
references: Nat Cell Biol. 2009 May;11(5):521-6
references: 19404331
references: J Clin Pathol. 2010 May;63(5):424-30
references: 20418234
references: Mol Microbiol. 2010 Sep;77(5):1246-60
references: 20662775
references: Clin Microbiol Rev. 2006 Jul;19(3):449-90
references: 16847081
references: Clin Microbiol Rev. 2006 Apr;19(2):315-37
references: 16614252
references: Biometals. 2009 Aug;22(4):583-93
references: 19350396
references: Clin Infect Dis. 2011 May;52(10):1212-7
references: 21498386
references: BMC Genomics. 2009 Jan 21;10:36
references: 19159446
references: J Bacteriol. 2007 Jun;189(12):4449-55
references: 17400735
references: PLoS One. 2010 Feb 24;5(2):e9394
references: 20195364
references: Infect Immun. 1982 Aug;37(2):662-9
references: 6811437
references: Mol Microbiol. 2007 Apr;64(2):512-33
references: 17493132
references: Recent Pat Antiinfect Drug Discov. 2009 Nov;4(3):190-205
references: 19594436
references: PLoS One. 2010 May 11;5(5):e10586
references: 20485672
references: Appl Environ Microbiol. 2010 Aug;76(15):5181-7
references: 20562286
references: Nat Rev Microbiol. 2004 Dec;2(12):946-53
references: 15550940
references: Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3943-8
references: 9520472
references: Epidemiol Rev. 2000;22(2):283-97
references: 11218379
references: Microbiol Rev. 1996 Sep;60(3):539-74
references: 8840786
references: Genome Res. 2008 Oct;18(10):1624-37
references: 18583645
references: Mol Microbiol. 2005 Jul;57(1):1-8
references: 15948944
references: PLoS Genet. 2009 Jan;5(1):e1000344
references: 19165319
references: Nucleic Acids Res. 2010 Oct;38(18):6089-101
references: 20478826
references: Microbiology (Reading). 2002 Nov;148(Pt 11):3681-3693
references: 12427958
references: J Bacteriol. 2010 Feb;192(3):771-8
references: 19948794
references: Contrib Microbiol. 2009;16:88-102
references: 19494580
references: Clin Microbiol Rev. 1993 Apr;6(2):137-49
references: 8472246
references: Nat Rev Microbiol. 2010 Jun;8(6):401-12
references: 20453875
references: Infect Immun. 2008 Jan;76(1):403-16
references: 17967858
references: Infect Immun. 1996 Jul;64(7):2877-80
references: 8698529
references: J Med Microbiol. 1996 Aug;45(2):110-9
references: 8683546
references: PLoS Pathog. 2010 Sep 09;6(9):e1001097
references: 20844578
references: Infect Immun. 2000 Dec;68(12):6511-8
references: 11083759
references: Mol Microbiol. 2008 Aug;69(4):1008-17
references: 18627458
references: Microbes Infect. 2000 Jan;2(1):55-60
references: 10717541
references: Microbiol Mol Biol Rev. 2010 Jun;74(2):171-99
references: 20508246
references: BMC Evol Biol. 2009 May 26;9:118
references: 19470179
references: Clin Microbiol Rev. 2004 Jan;17(1):14-56
references: 14726454
references: Infect Immun. 2010 Jun;78(6):2723-33
references: 20385761
references: J Bacteriol. 2001 Apr;183(8):2463-75
references: 11274105