title: Protective effects of exogenous hydrogen sulfide on neurons of hippocampus in a rat model of brain ischemia.
abstract: Many studies have demonstrated the cytoprotective effects of hydrogen sulfide (H(2)S) in vitro and/or in vivo ischemic injury. The aim of the current study was to investigate whether exogenous H(2)S attenuates the neuronal injury induced by brain ischemia. As an H(2)S donor, sodium hydrosulfide (NaHS) was administered intraperitoneally (5.6 mg/kg/day, i.p.). The effects of exogenous H(2)S on neurons of ischemic hippocampus were examined by using measurement of behavior, electrophysiology, morphology and immunohistochemical staining, respectively. Our results showed that exogenous H(2)S significantly improved spatial learning and memory deficits induced by brain ischemia (P < 0.01). Exogenous H(2)S enhanced synaptic plasticity in the hippocampus of brain-ischemic rats, inhibited the edema around pyramidal neurons and the nuclear shrink induced by ischemia, and promoted the expression of growth-associated protein-43 (GAP-43) in the CA1 region of hippocampus post ischemia. The results suggest a protective effect and therapeutic potential of H(2)S in the treatment of brain ischemia.
authors: Key Laboratory of Bioactive Materials, Ministry of Education and College of Life Science, Nankai University, Tianjin 300071, People's Republic of China.
authors: Zhanyong
authors: Z
authors: Li
authors: Yiyi
authors: Y
authors: Wang
authors: Yongling
authors: Y
authors: Xie
authors: Zhuo
authors: Z
authors: Yang
authors: Tao
authors: T
authors: Zhang
references: Can J Physiol Pharmacol. 2003 Sep;81(9):848-53
references: 14614520
references: Life Sci. 2008 Jun 6;82(23-24):1196-202
references: 18482739
references: Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):661-70
references: 16677109
references: Br J Pharmacol. 1995 Dec;116(8):3093-8
references: 8719782
references: Brain Res. 2010 Jul 23;1345:197-205
references: 20478278
references: Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H801-6
references: 18567706
references: Biochem Biophys Res Commun. 2009 Oct 30;388(4):718-22
references: 19695225
references: J Pharmacol Exp Ther. 2006 Feb;316(2):670-8
references: 16204473
references: Phytother Res. 2010 Jan;24(1):136-40
references: 19688719
references: Stroke. 1979 May-Jun;10(3):267-72
references: 37614
references: Basic Res Cardiol. 2006 Jan;101(1):53-60
references: 16328106
references: EMBO J. 2001 Nov 1;20(21):6008-16
references: 11689441
references: Pharmacol Res. 2010 Oct;62(4):289-97
references: 20542117
references: Neuron. 2004 Sep 30;44(1):5-21
references: 15450156
references: Antioxid Redox Signal. 2009 Jan;11(1):25-33
references: 18837652
references: Stroke. 2006 Mar;37(3):889-93
references: 16439695
references: Life Sci. 2009 Aug 12;85(7-8):269-75
references: 19540852
references: Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15560-5
references: 17878306
references: Nat Rev Drug Discov. 2007 Nov;6(11):917-35
references: 17948022
references: J Neurosci. 1996 Feb 1;16(3):1066-71
references: 8558235
references: Neurochem Res. 2009 Nov;34(11):1984-92
references: 19488854
references: Liver Transpl. 2009 Oct;15(10):1306-14
references: 19790158
references: Neuroscience. 2010 May 5;167(2):277-86
references: 20149843
references: Neurol Res. 1993 Apr;15(2):128-30
references: 8099207
references: Neuroscience. 2010 Aug 11;169(1):214-22
references: 20438813
references: J Neurochem. 2009 Feb;108(3):676-84
references: 19054275
references: Science. 1999 Sep 17;285(5435):1870-4
references: 10489359
references: Neurochem Res. 2007 Nov;32(11):1875-83
references: 17549628
references: Circulation. 2009 Sep 8;120(10):888-96
references: 19704099
references: Biochem Biophys Res Commun. 2000 Jan 7;267(1):129-33
references: 10623586
references: J Neurotrauma. 2009 Oct;26(10):1695-706
references: 19785543
references: Antioxid Redox Signal. 2009 Feb;11(2):205-14
references: 18754702
references: Prog Brain Res. 1990;86:309-20
references: 2150888
references: FASEB J. 2004 Jul;18(10):1165-7
references: 15155563
references: J Am Soc Nephrol. 2009 Sep;20(9):1901-5
references: 19628669
references: Lab Invest. 2008 Oct;88(10):1038-48
references: 18679378
references: Am J Physiol Renal Physiol. 2009 Jul;297(1):F27-35
references: 19439522
references: Acta Neurol Scand. 1984 Jun;69(6):385-401
references: 6464670
references: J Appl Physiol (1985). 2006 Mar;100(3):1065-76
references: 16467393
references: Neurochem Int. 2010 Jan;56(1):3-10
references: 19703504
references: Pharmacol Rep. 2007 Jan-Feb;59(1):4-24
references: 17377202
references: Trends Pharmacol Sci. 2008 Feb;29(2):84-90
references: 18180046
references: Eur J Cardiothorac Surg. 2008 Aug;34(2):344-9
references: 18455926
references: FASEB J. 2004 Mar;18(3):557-9
references: 14734631
references: Antioxid Redox Signal. 2009 Apr;11(4):703-14
references: 18855522
references: Plast Reconstr Surg. 2010 Jun;125(6):1670-1678
references: 20517090
references: FASEB J. 2002 Nov;16(13):1792-8
references: 12409322
references: Biochem Biophys Res Commun. 1997 Aug 28;237(3):527-31
references: 9299397
references: Gen Pharmacol. 1998 Apr;30(4):431-4
references: 9522158
references: Neurosci Lett. 2008 Jun 20;438(2):180-5
references: 18456407
references: Shock. 2006 Aug;26(2):154-61
references: 16878023
references: Antioxid Redox Signal. 2010 Jan;12(1):1-13
references: 19852698
references: Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7657-62
references: 10861025