title: The C-terminal part of human melanoma growth stimulating activity (MGSA/GRO alpha) binds to neutrophils but does not stimulate enzyme release.
abstract: CXC chemokines are known to bind to their receptors on neutrophils and activate them through the N-terminal ELR box. In this study, we show that the C-terminal alpha helix of human MGSA does bind to neutrophils, but contrary to complete MGSA, is unable to promote enzyme release by neutrophils. These results raise the possibility of MGSA being a multi-functional molecule with various domains of activation.
authors: UNIV LAVAL,FAC MED,DEPT BIOCHEM,QUEBEC CITY,PQ G1K 7P4,CANADA.
authors: P
authors: P
authors: Roby
authors: M
authors: M
authors: Page