title: Immunomodulatory effect of (--)-matairesinol in vivo and ex vivo.
abstract: Matairesinol is one of the lignan compounds found in a variety of plant foodstuffs. We investigated the immunomodulatory effects of (-)-matairesinol in vivo and ex vivo by using mice. Although we found no significant differences in the IgG, IgA and IgM levels in the serum, the IgE level was strongly suppressed by the uptake of (-)-matairesinol in both intact and ovalbumin-immunized mice. The immunoglobulin produced by lymphocytes from the spleen was not activated by the intake of (-)-matairesinol. However, lymphocytes in such gut-associated lymphatic tissues as Peyer's patches and mesenteric lymph nodes were activated by the administration of (-)-matairesinol.
authors: Faculty of Agriculture, Ehime University, Ehime, Japan.
authors: Manami
authors: M
authors: Yamawaki
authors: Kosuke
authors: K
authors: Nishi
authors: Sogo
authors: S
authors: Nishimoto
authors: Satoshi
authors: S
authors: Yamauchi
authors: Koichi
authors: K
authors: Akiyama
authors: Taro
authors: T
authors: Kishida
authors: Masafumi
authors: M
authors: Maruyama
authors: Hisashi
authors: H
authors: Nishiwaki
authors: Takuya
authors: T
authors: Sugahara