title: Efficient route to atropisomeric ligands--application to the synthesis of MeOBIPHEP analogues.
abstract: A highly efficient Pd-catalyzed P-C coupling reaction of easily accessible atropisomeric bisphosphane is described in the presence of various electron-poor aromatic iodides. The reactions are conducted in the presence of a Pd(II)/dppf catalyst in acetonitrile at 80 °C. The reaction conditions are compatible with several electron-withdrawing groups such as esters, cyano, chloro, and trifluoromethyl groups and lead to atropisomeric MeOBIPHEP derivatives in good to excellent yields and high enantiomeric purities.
authors: Chimie ParisTech, UMR 7223, Laboratoire Charles Friedel 11 rue P. et M. Curie, 75231 Paris Cedex 05, France.
authors: Lucie
authors: L
authors: Leseurre
authors: Florent Le Boucher
authors: Fle B
authors: d'Herouville
authors: Kurt
authors: K
authors: Püntener
authors: Michelangelo
authors: M
authors: Scalone
authors: Jean-Pierre
authors: JP
authors: Genêt
authors: Véronique
authors: V
authors: Michelet