title: Synthesis of unsymmetrical diarylureas via Pd-catalyzed C-N cross-coupling reactions.
abstract: A facile synthesis of unsymmetrical N,N'-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation-deprotection protocol, followed by a second arylation.
authors: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors: Simon
authors: S
authors: Breitler
authors: Nathan J
authors: NJ
authors: Oldenhuis
authors: Brett P
authors: BP
authors: Fors
authors: Stephen L
authors: SL
authors: Buchwald
references: Org Lett. 2009 Feb 19;11(4):947-50
references: 19178160
references: Org Lett. 2009 Dec 17;11(24):5622-5
references: 19908883
references: J Org Chem. 2005 Aug 19;70(17):6960-3
references: 16095326
references: ACS Med Chem Lett. 2010 Dec 9;1(9):460-465
references: 21243104
references: Org Lett. 2006 Oct 26;8(22):5089-91
references: 17048850
references: Org Lett. 2006 Jul 20;8(15):3311-4
references: 16836393
references: Org Lett. 2010 Oct 1;12(19):4220-3
references: 20809613
references: Tetrahedron. 2009 Aug 15;65(33):6576-6583
references: 20740063
references: J Org Chem. 2000 May 19;65(10):3239-40
references: 10814225
references: Bioorg Med Chem Lett. 2009 Aug 1;19(15):4259-63
references: 19520575
references: Invest New Drugs. 2012 Apr;30(2):490-507
references: 21080210
references: Org Lett. 2009 Apr 2;11(7):1527-30
references: 19254041
references: ACS Med Chem Lett. 2010 Aug 20;1(9):472-7
references: 24900233
references: Org Lett. 2007 Apr 12;9(8):1517-20
references: 17358074
references: Org Lett. 2008 Aug 21;10(16):3567-70
references: 18642922
references: Nat Rev Drug Discov. 2006 Oct;5(10):835-44
references: 17016424
references: Org Lett. 2008 Aug 21;10(16):3505-8
references: 18620415
references: Org Lett. 2010 Mar 19;12(6):1340-3
references: 20175533
references: J Am Chem Soc. 2001 Jun 6;123(22):5213-20
references: 11457383
references: J Org Chem. 2000 Mar 10;65(5):1549-51
references: 10814121
references: J Org Chem. 2009 Dec 18;74(24):9539-42
references: 19928811