title: Latrophilin signalling in tissue polarity and morphogenesis.
abstract: Understanding the mechanisms that coordinate the polarity of cells and tissues during embryogenesis and morphogenesis is a fundamental problem in developmental biology. We have recently demonstrated that the putative neurotoxin receptor lat-1 defines a mechanism required for the alignment of cell division planes in the early embryo of the nematode C. elegans. Our analysis suggests that lat-1 is required for the propagation rather than the initial establishment of polarity signals. Similar to the role of the flamingo/CELSR protein family in the control of planar cell polarity, these results implicate an evolutionary conserved subfamily of adhesion-GPCRs in the control of tissue polarity and morphogenesis.
authors: Institute of Physiology, University of Würzburg, 97070 Würzburg, Germany. tobias.langenhan@uni-wuerzburg.de
authors: Tobias
authors: T
authors: Langenhan
authors: Andreas P
authors: AP
authors: Russ