title: [The association between HBV genotyping and clinical characteristics and expression of TH1/TH2 cytokines].
abstract: OBJECTIVE
  To explore the association between HBV genotyping and clinical characteristics and expression of TH1/TH2 cytokines.
  
  
  METHODS
  The expression of IL-4 and IFN-gamma was detected with flow cytometry for 102 HBV infections and 48 healthy controls. 50 CHB patients were randomly selected for HBV genotyping with real-time fluorescence PCR assay.
  
  
  RESULTS
  Higher expression of IL-4 in peripheral blood was detected in patients with HBV infection than healthy controls (P < 0.001); No significant differences on expression of Th1/Th2 cytokines were observed in CHB patients with different HBV DNA levels or HBeAg status (P > 0.05). There were 34 (68%) patients with genotype B infection and 16 (32%) with genotype C infection. Compared to patients with genotype B infection, the patients with genotype C infection showed higher levels of IL-4 (P = 0.018), and Th1/Th2 ratio decreased,but the difference was not statistically significant (P = 0.2262).
  
  
  CONCLUSIONS
  The different expression of TH1/TH2 cytokines may elucidate cellular immune response and clinical outcome difference between patients with genotype B infection and genotype C infection.
authors: Shenzhen Third People's Hospital, Guangdong Medical College, Shenzhen 518020, China.
authors: Si-Min
authors: SM
authors: Yao
authors: Jing
authors: J
authors: Yuan
authors: Fan
authors: F
authors: Zhang
authors: Xin-Chun
authors: XC
authors: Chen
authors: Ming-Xia
authors: MX
authors: Zhang
authors: Hong
authors: H
authors: Liu
authors: Ying-Xia
authors: YX
authors: Liu
authors: Bin
authors: B
authors: Wen
authors: Ming
authors: M
authors: Wu
authors: Wei
authors: W
authors: Dai
authors: Dong
authors: D
authors: Wang
authors: Bo-Ping
authors: BP
authors: Zhou