title: A specific prebiotic mixture added to starting infant formula has long-lasting bifidogenic effects.
abstract: There is some evidence that early colonization of the intestine affects the composition of the intestinal microbiota after weaning. In the present study, the effect of prebiotics administered from the first day of life on fecal counts of bifidobacteria and lactobacilli were studied during and after the administration of the prebiotics. In this double-blind, randomized, placebo-controlled, explorative study, 20 newborns of hepatitis C virus-infected mothers who decided not to breast feed due to their concerns regarding their plasma viral load were randomly assigned to either a formula with 8 g/L of a specific prebiotic mixture (short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides, ratio 9:1) or a formula containing the same amount of maltodextrin (placebo). Clinical examination including anthropometric measurements, microbiological analysis of fecal samples, and blood leukocyte population analysis were performed at birth and 3, 6, and 12 mo age. At the age of 12 mo, hepatitis B vaccine-specific IgG serum titers (Hepatitis B virus surface antibodies) were also measured. Prebiotic supplementation resulted in more fecal bifidobacteria (P < 0.0001) and lactobacilli (P = 0.0044) compared with the placebo group. These differences between the groups were maintained during the second half of the first year without any prebiotic supplementation. There was no influence of the different diets on anthropometric data or the measured immunological variables. The data from this small explorative study indicate that early colonization of the intestine might have long-lasting effects on the composition of the intestinal microbiota.
authors: Paediatric Department, University of Milan, San Paolo Hospital, Milan 20142, Italy. Filippo.Salvini@ao-sanpaolo.it
authors: Filippo
authors: F
authors: Salvini
authors: Enrica
authors: E
authors: Riva
authors: Elisabetta
authors: E
authors: Salvatici
authors: Günther
authors: G
authors: Boehm
authors: Jürgen
authors: J
authors: Jelinek
authors: Giuseppe
authors: G
authors: Banderali
authors: Marcello
authors: M
authors: Giovannini
references: J Nutr. 2006 Aug;136(8):2127-30
references: 16857829
references: J Nutr. 2009 Jul;139(7):1398-403
references: 19474160
references: J Pediatr Gastroenterol Nutr. 2007 Mar;44(3):392-7
references: 17325568
references: J Pediatr Gastroenterol Nutr. 2006 May;42(5):488-95
references: 16707969
references: Clin Nutr. 2009 Apr;28(2):156-61
references: 19231042
references: Nutr Res Rev. 2004 Dec;17(2):259-75
references: 19079930
references: J Nutr. 2008 Sep;138(9):1782S-1790S
references: 18716187
references: ISME J. 2007 May;1(1):56-66
references: 18043614
references: J Med Microbiol. 1982 May;15(2):189-203
references: 7143428
references: J Nutr. 2005 Jan;135(1):1-4
references: 15623823
references: Annu Rev Nutr. 2000;20:699-722
references: 10940350
references: Int Immunopharmacol. 2007 Dec 5;7(12):1582-7
references: 17920536
references: Microbiology (Reading). 2010 Nov;156(Pt 11):3329-3341
references: 20864478
references: J Appl Bacteriol. 1989 May;66(5):365-78
references: 2666378
references: Acta Paediatr. 2003 May;92(5):634-5
references: 12839299
references: J Nutr. 2008 Sep;138(9):1818S-1828S
references: 18716193
references: Pediatr Allergy Immunol. 2010 Mar;21(2 Pt 2):e377-85
references: 20003064
references: J Pediatr Gastroenterol Nutr. 2006 Aug;43(2):200-5
references: 16877985
references: J Nutr. 2008 Jun;138(6):1141-7
references: 18492847
references: J Allergy Clin Immunol. 2010 Jun;125(6):1308-14
references: 20434201
references: Acta Paediatr Suppl. 2003 Sep;91(441):64-7
references: 14599044
references: Gut. 2005 Mar;54(3):317-20
references: 15710972
references: J Nutr. 2008 Jun;138(6):1091-5
references: 18492839
references: Am J Clin Nutr. 1999 May;69(5):1052S-1057S
references: 10232648
references: Allergy. 2009 Mar;64(3):484-7
references: 18507650
references: J Pediatr Gastroenterol Nutr. 2004 Aug;39(2):147-52
references: 15269618
references: Br J Nutr. 2005 Sep;94(3):452-81
references: 16176618
references: J Nutr. 2008 Sep;138(9):1796S-1800S
references: 18716189
references: Gut. 2004 Sep;53(9):1388-9
references: 15306608
references: Early Hum Dev. 2001 Nov;65 Suppl:S43-52
references: 11755034
references: J Nutr. 2008 Sep;138(9):1791S-1795S
references: 18716188
references: J Pediatr Gastroenterol Nutr. 1999 Jan;28(1):19-25
references: 9890463
references: J Med Microbiol. 2005 Dec;54(Pt 12):1239-1242
references: 16278440
references: J Hepatol. 2005 Sep;43(3):515-25
references: 16144064
references: J Pediatr Gastroenterol Nutr. 2004 Jun;39 Suppl 3:S772-3
references: 15167384
references: J Nutr. 2007 Nov;137(11):2420-4
references: 17951479
references: J Pediatr Gastroenterol Nutr. 1997 May;24(5):497-505
references: 9161941
references: Crit Rev Immunol. 2007;27(2):97-140
references: 17725499
references: Arch Dis Child. 2006 Oct;91(10):814-9
references: 16873437
references: Pediatrics. 2006 Aug;118(2):511-21
references: 16882802
references: FEMS Microbiol Ecol. 2006 Dec;58(3):563-71
references: 17117997
references: Dig Liver Dis. 2006 Dec;38 Suppl 2:S291-4
references: 17259094