title: Seroprevalence and risk factors for hepatitis B infection in an adult population in Northeast China.
abstract: OBJECTIVE
  The prevalence of the hepatitis B virus (HBV) is higher in adults than in children. We determined the seroepidemiology of HBV infection in an adult population in JiLin, China, to guide effective preventive measures.
  
  
  METHODS
  A cross-sectional serosurvey was conducted throughout JiLin, China. A total of 3833 people was selected and demographic and behavioral information gathered. Serum samples were tested for HBV markers and liver enzymes.
  
  
  RESULTS
  The prevalence of the hepatitis B surface antigen (HBsAg), the antibody to the hepatitis B surface antigen (anti-HBs), the hepatitis B e antigen (HBeAg), the antibody to HBeAg (anti-HBe), and the antibody to the hepatitis B core antigen (anti-HBc) were 4.38%, 35.66%, 1.38%, 6.65%, and 40.88%, respectively. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were significantly higher among HBsAg (+) than HBsAg (-) subjects. By multivariate logistic regression analysis, independent predictors for chronic HBV infection were smoking, poor sleep quality; occupation as private small-businessmen, laborers, or peasants; male gender; family history of HBV; personal history of vaccination; and older age. Independent predictors for exposure to HBV were large family size, occupation as a private small-businessman, male gender, family history of HBV, personal history of vaccination, and older age. Independent predictors for immunity by vaccination were occupation as a private small-businessman, high income, personal history of vaccination, and young age. Independent predictors for immunity by exposure were drinking, male gender, personal history of vaccination, and older age.
  
  
  CONCLUSIONS
  The prevalence rate of HBV infection (4.38%) was lower than the previous rate of general HBV vaccination. However, 44.59% of the population remained susceptible to HBV. The prevalence of HBV infection was high in young adults, private small-businessmen, peasants, those with a family history of HBV, and males. Therefore, immunization of the non-immune population is reasonable to reduce hepatitis B transmission between adults.
authors: Department of Hepatology, First Hospital, Jilin University, Changchun 130021, China.
authors: Hong
authors: H
authors: Zhang
authors: Qingmei
authors: Q
authors: Li
authors: Jie
authors: J
authors: Sun
authors: Chunyan
authors: C
authors: Wang
authors: Qing
authors: Q
authors: Gu
authors: Xiangwei
authors: X
authors: Feng
authors: Bing
authors: B
authors: Du
authors: Wei
authors: W
authors: Wang
authors: Xiaodong
authors: X
authors: Shi
authors: Siqi
authors: S
authors: Zhang
authors: Wanyu
authors: W
authors: Li
authors: Yanfang
authors: Y
authors: Jiang
authors: Junyan
authors: J
authors: Feng
authors: Shumei
authors: S
authors: He
authors: Junqi
authors: J
authors: Niu
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