title: Mutagen sensitivity and cancer susceptibility in patients with multiple primary cancers.
abstract: Thirty-two patients with multiple cancers were evaluated for in vitro sensitivity to mutagens and were compared with normal controls, Mutagen sensitivity was evaluated by exposing lymphocytes to mitomycin-C in vitro and estimating the mitomycin-induced chromosomal gaps and breaks (G/B) and sister chromatid exchanges (SCE) per cell. The results show significant differences between control and patient groups when spontaneous and induced G/B and SCE were evaluated. In addition, establishing the limit of normality for G/B and SCE, among the control group, the examined patients show largely positive levels in respect to both of the parameters used. In this study we discuss the usefulness of mutagen sensitivity as an indirect measure of DNA repair and genetic susceptibility to multiple primary cancers.
authors: NATL CANC INST ROME,DEPT CLIN PATHOL,ROME,ITALY. NATL CANC INST ROME,DEPT MED ONCOL,ROME,ITALY. S GIUSEPPE HOSP,DEPT UROL,ROME,ITALY.
authors: A
authors: A
authors: Cianciulli
authors: I
authors: I
authors: Venturo
authors: F
authors: F
authors: Leonardo
authors: S
authors: S
authors: Antonaci
authors: C
authors: C
authors: Greco
authors: M
authors: M
authors: Lopez
authors: G
authors: G
authors: Gandolfo