title: [Dupuytren's disease: state of knowledge and research in physiopathology].
abstract: From Baron Dupuytren's historical description up to the advent of molecular biology, many hypotheses about the etiology of Dupuytren's disease have been proposed. This bibliography of the last ten years' publications describes tissue anomalies from the macroscopic down to the ultrastructural level of pathology. The myofibroblast, which is the principal cell of the disease, is the seat of genetics anomalies involving proto-oncogenes (c-myc and MafB). Similarly, glycoproteins implicated in cellular adhesion like fibronectins and catenins are modified and overexpressed in the disease. Extracellular proteins of the metalloproteinase family exhibit many dysfunctions responsible for collagenic proliferation. Finally, growth factors like Transforming Growth Factor (TGF) and Epidermal Growth Factor (EGF) receptor maintain and worsen the disease and could be therapeutic targets in the future.
authors: Service de chirurgie plastique et de la main, CHU de Rouen, 4, rue de Germont, 76000 Rouen, France. gilbert.carvalhana@libertysurf.fr
authors: G
authors: G
authors: Carvalhana
authors: I
authors: I
authors: Auquit-Auckbur
authors: P-Y
authors: PY
authors: Milliez