title: Streptozotocin-induced diabetes accelerates mammary tumorigenesis in shn and sln mice.
abstract: Virgin female SHN and SLN mice, a high and a low spontaneous mammary tumor strains, respectively, were given a single intravenous injection of streptozotocin (2 mg/10 g body weight), resulting in a significant rise of blood glucose levels and of mammary tumor incidence. The growth rate of mammary tumors was also accelerated by streptozotocin-induced diabetes in SHN mice, but not in SLN mice. The incidence and progression of uterine adenomyosis and adenocarcinoma were not affected by diabetes in SHN and SLN mice. These findings indicate that spontaneous mammary tumorigenesis in SHN and SLN mice is accelerated by streptozotocin-induced diabetes.
authors: YOKOHAMA CITY UNIV,GRAD SCH INTEGRATED SCI,22-2 SETO,KANAZAWA KU,YOKOHAMA 236,JAPAN. MEIJI UNIV,EXPTL ANIM RES LAB,TAMA KU,KAWASAKI 214,JAPAN.
authors: Y
authors: Y
authors: Goto
authors: H
authors: H
authors: Nagasawa
authors: T
authors: T
authors: Iguchi