title: Macrophage colony-stimulating factor as a marker of ovarian carcinoma.
abstract: Macrophage colony stimulating factor (M-CSF) is a cytokine which stimulates the proliferation and differentiation of phagocytic cells. We evaluated the usefulness of M-CSF as a serum tumor marker for ovarian malignancies and also assessed M-CSF production by tumor cells and the role of an autocrine system in such M-CSF production. The findings obtained were as follows: i) Serum M-CSF was a useful marker for malignant ovarian tumors. ii) M-CSF was a marker for both epithelial stromal tumors and for germ cell tumors. It was also a marker for dysgerminoma, for which no specific tumor marker is currently available. iii) The value of combined assays employing M-CSF was confirmed. iv) M-CSF production was demonstrated in various malignant ovarian tumor cell lines, but the presence of an autocrine system for M-CSF was not confirmed.
authors: KANSAI MED UNIV,DEPT PATHOL 2,MORIGUCHI,OSAKA 570,JAPAN.
authors: N
authors: N
authors: Ookura
authors: H
authors: H
authors: Nishimura
authors: Y
authors: Y
authors: Kiyozuka
authors: K
authors: K
authors: Komai
authors: K
authors: K
authors: Ushijima
authors: T
authors: T
authors: Sugiyama
authors: T
authors: T
authors: Nishida
authors: M
authors: M
authors: Yakushiji