title: 18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism.
abstract: BACKGROUND
  18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2). The potential for this steroid as a biomarker for differentiating patients with aldosterone-producing adenoma (APA) from those with idiopathic hyperaldosteronism (IHA) has not been examined.
  
  
  OBJECTIVE
  We measured 18-oxoF, aldosterone, and F in plasma from adrenal vein sampling (AVS) of patients with primary aldosteronism. We compared 18-oxoF levels and 18-oxoF/F ratios for their potential to differentiate APA from IHA.
  
  
  METHODS
  This study measured 18-oxoF, F, and aldosterone in AVS obtained from patients with unilateral APA (14 cases) or bilateral IHA (seven cases, 14 samples total) using liquid chromatography-tandem mass spectrometry and RIA analyses.
  
  
  RESULTS
  The levels of 18-oxoF and the ratios of 18-oxoF/F, before and after ACTH stimulation, were significantly higher in blood-draining APA than in those from the contralateral adrenal glands and from adrenal glands with IHA.
  
  
  CONCLUSIONS
  The 18-oxoF levels and ratios of 18-oxoF/F in AVS samples can be a clinically useful biomarker for differentiating APA from IHA and for determining the localization or lateralization of APA in patients with primary aldosteronism.
authors: Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai 980-8574, Japan.
authors: Yasuhiro
authors: Y
authors: Nakamura
authors: Fumitoshi
authors: F
authors: Satoh
authors: Ryo
authors: R
authors: Morimoto
authors: Masataka
authors: M
authors: Kudo
authors: Kei
authors: K
authors: Takase
authors: Celso E
authors: CE
authors: Gomez-Sanchez
authors: Seijiro
authors: S
authors: Honma
authors: Mitsunobu
authors: M
authors: Okuyama
authors: Kouwa
authors: K
authors: Yamashita
authors: William E
authors: WE
authors: Rainey
authors: Hironobu
authors: H
authors: Sasano
authors: Sadayoshi
authors: S
authors: Ito
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