title: [Metabolism of mangiferin by human intestinal bacteria in vitro].
abstract: OBJECTIVE
  To study the metabolism of mangiferin by human intestinal bacteria in vitro.
  
  
  METHODS
  Human intestinal bacteria and mangiferin were incubated under anaerobic conditions in vitro. The metabolite was separated and purified by D101 macroporous resin column and preparation high performance liquid chromatography, and its structure was identified by MS and NMR.
  
  
  RESULTS
  After 12 h incubation with human intestinal bacteria, the content of mangiferin metabolite reached the maximum, and it was determined as 1, 3, 6, 7-tetrahydroxyxanthen by MS and NMR.
  
  
  CONCLUSIONS
  Mangiferin can be metabolized in vitro by human intestinal bacteria into its aglycone (1, 3, 6, 7-tetrahydroxyxanthen).
authors: Faculty of Pharmaceutical Science, Guangxi Traditional Chinese Medical University, Nanning 530001, China. hhx123@yahoo.com.cn
authors: Huixue
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