title: Prognostic value of fluorine-18 fluorodeoxyglucose positron-emission tomography imaging in patients with head and neck squamous cell carcinoma.
abstract: BACKGROUND
  High tumor uptake of fluorodeoxyglucose (FDG) is associated with an unfavorable outcome in patients with cancer. We evaluated FDG uptake as a prognostic factor in patients with head and neck squamous cell carcinoma.
  
  
  METHODS
  Maximum standardized uptake values (SUVmax) of tumor, liver, and pulmonary artery were recorded. Ratios of SUVmax from tumor to liver (T/L) and from tumor to pulmonary artery (T/PA) were calculated for each patient. Clinical data, tumor, and SUVmax ratios were compared with disease-free survival (DFS) and overall survival (OS).
  
  
  RESULTS
  Eighty-nine patients were included: 48 presented a local recurrent disease or distant metastases and 42 died. For both DFS and OS, tumor SUVmax value of 7 was the best cutoff value and 4 and 5 for T/L and T/PA ratios. Multivariate analysis confirmed the independent prognostic value of these 3 thresholds for DFS and OS.
  
  
  CONCLUSIONS
  FDG uptake has a significant and independent relationship with recurrence and survival.
authors: Nuclear Medicine Department, University Hospital of Brest, Brest, France.
authors: Solène
authors: S
authors: Querellou
authors: Ronan
authors: R
authors: Abgral
authors: Pierre-Yves
authors: PY
authors: Le Roux
authors: Emmanuel
authors: E
authors: Nowak
authors: Gérald
authors: G
authors: Valette
authors: Gaël
authors: G
authors: Potard
authors: Alexandra
authors: A
authors: Le Duc-Pennec
authors: Marie-Béatrice
authors: MB
authors: Cavarec
authors: Rémi
authors: R
authors: Marianovski
authors: Pierre-Yves
authors: PY
authors: Salaün