title: Immunogenicity of the hydrophilic region of the MUC1 mucin protein core.
abstract: This report is an analysis of data relating to the epitopes of 28 murine monoclonal antibodies reactive with the protein core of human carcinoma-associated MUC1 mucins. All anti-MUC1 antibodies define epitopes of linear sequences of 3, 4 or 5 amino acids within the hydrophilic domain, APDTRPAP, which is expressed multiple times in a highly conserved 20 amino acid repeat sequence of the MUC1 core. The R residue is present in the epitopes defined by all of the 28 anti-MUC1 monoclonal antibodies. Epitopes of antibodies originally prepared against immunogens containing human milk fat globule membranes include the motif DTR in over 90% of the examples studied.
authors: M
authors: M
authors: Price
authors: E
authors: E
authors: Petrakou
authors: M
authors: M
authors: Sekowski
authors: A
authors: A
authors: Murray