title: Design and synthesis of a bombesin peptide-conjugated tripodal phosphino dithioether ligand topology for the stabilization of the fac-[M(CO)3]+ core (M=(99 m)Tc or Re).
abstract: A new tumor-seeking tridentate topology consisting of a phosphino dithioether ((HOCH(2))(2)PCH(2)CH(2)S(CH(2))(n)CH(2)SR; PS(2)) ligand framework for the production of kinetically inert and in vivo stable facial [(99m)Tc(CO)(3)(PS(2))](+) or [Re(CO)(3)(PS(2))](+) is described. The X-ray crystal structure of fac-Re(CO)(3)(PS(2))PF(6) is reported. The bioconjugation strategies for incorporating bombesin (BBN) peptides on to the PS(2) tripodal framework and, thereby, de novo designing of GRP receptor-seeking Tc(PS(2)-BBN)(CO)(3) are developed.
authors: Department of Radiology, University of Missouri, Columbia, Missouri 65211, USA. kannanr@health.missouri.edu
authors: Raghuraman
authors: R
authors: Kannan
authors: Nagavarakishore
authors: N
authors: Pillarsetty
authors: Hariprasad
authors: H
authors: Gali
authors: Timothy J
authors: TJ
authors: Hoffman
authors: Charles L
authors: CL
authors: Barnes
authors: Silvia S
authors: SS
authors: Jurisson
authors: Charles J
authors: CJ
authors: Smith
authors: Wynn A
authors: WA
authors: Volkert
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