title: Detection of herpesvirus-like DNA sequences in Mediterranean Kaposi's sarcoma.
abstract: The aetiology of Kaposi's sarcoma remains obscure, however, epidemiological studies indicate that the disease possesses an infectious aetiology. Recent data revealed the presence of specific herpesvirus-like DNA sequences (KHSV) in all forms of Kaposi's sarcoma indicating that a novel virus may be the infectious agent which causes the disease. The aim of the present investigation was to assess the incidence of this herpesvirus-like DNA sequence in 28 Mediterranean Kaposi's sarcomas. DNA was extracted from formalin-fixed paraffin-embedded tissues and analysed by a sensitive PCR based assay. The KSHV specific DNA sequences were found in 22 of 28 (79%) cases suggesting a potential important role in the development of the disease.
authors: NATL HELLEN RES FND,INST BIOL RES & BIOTECHNOL,GR-11635 ATHENS,GREECE. UNIV CRETE,SCH MED,IRAKLION,GREECE. RED CROSS HOSP,PATHOL LAB,ATHENS,GREECE. HIPPOKRATIO GEN HOSP,PATHOL LAB,ATHENS,GREECE.
authors: H
authors: H
authors: Kiaris
authors: M
authors: M
authors: Ergazaki
authors: I
authors: I
authors: Nikolaou
authors: K
authors: K
authors: Papadimitriou
authors: D
authors: D
authors: Spandidos