title: Mechanisms of rule acquisition and rule following in inductive reasoning.
abstract: Despite the recent interest in the neuroanatomy of inductive reasoning processes, the regional specificity within prefrontal cortex (PFC) for the different mechanisms involved in induction tasks remains to be determined. In this study, we used fMRI to investigate the contribution of PFC regions to rule acquisition (rule search and rule discovery) and rule following. Twenty-six healthy young adult participants were presented with a series of images of cards, each consisting of a set of circles numbered in sequence with one colored blue. Participants had to predict the position of the blue circle on the next card. The rules that had to be acquired pertained to the relationship among succeeding stimuli. Responses given by subjects were categorized in a series of phases either tapping rule acquisition (responses given up to and including rule discovery) or rule following (correct responses after rule acquisition). Mid-dorsolateral PFC (mid-DLPFC) was active during rule search and remained active until successful rule acquisition. By contrast, rule following was associated with activation in temporal, motor, and medial/anterior prefrontal cortex. Moreover, frontopolar cortex (FPC) was active throughout the rule acquisition and rule following phases before a rule became familiar. We attributed activation in mid-DLPFC to hypothesis generation and in FPC to integration of multiple separate inferences. The present study provides evidence that brain activation during inductive reasoning involves a complex network of frontal processes and that different subregions respond during rule acquisition and rule following phases.
authors: Cognitive Neuroscience Sector, International School for Advanced Studies, 34136 Trieste, Italy. crescent@sissa.it
authors: Cristiano
authors: C
authors: Crescentini
authors: Shima
authors: S
authors: Seyed-Allaei
authors: Nicola
authors: N
authors: De Pisapia
authors: Jorge
authors: J
authors: Jovicich
authors: Daniele
authors: D
authors: Amati
authors: Tim
authors: T
authors: Shallice
references: Nat Rev Neurosci. 2004 Mar;5(3):184-94
references: 14976518
references: Neuroimage. 2005 Jul 15;26(4):1140-9
references: 15961050
references: Neurobiol Aging. 2010 May;31(5):839-52
references: 18674847
references: Cogn Affect Behav Neurosci. 2004 Dec;4(4):564-79
references: 15849898
references: Brain Res Cogn Brain Res. 1998 Jul;7(1):1-13
references: 9714705
references: Magn Reson Med. 2004 Nov;52(5):1156-66
references: 15508146
references: Exp Brain Res. 1999 Jun;126(3):315-35
references: 10382618
references: J Neurosci. 2005 Nov 9;25(45):10347-50
references: 16280570
references: Neuropsychologia. 2000;38(9):1316-24
references: 10865107
references: Eur J Neurosci. 2000 Oct;12(10):3787-96
references: 11029649
references: Behav Neurosci. 2001 Oct;115(5):971-82
references: 11584930
references: Neuroimage. 2005 Apr 15;25(3):653-60
references: 15808966
references: Cereb Cortex. 2011 Jan;21(1):1-10
references: 20483908
references: Neuropsychologia. 2000;38(6):848-63
references: 10689059
references: Hum Brain Mapp. 2009 May;30(5):1734-43
references: 18729079
references: Trends Cogn Sci. 2010 Apr;14(4):180-90
references: 20206576
references: Trends Cogn Sci. 2005 Jul;9(7):314-6
references: 15927520
references: Neuropsychologia. 2001;39(6):545-55
references: 11257280
references: J Cogn Neurosci. 2007 Dec;19(12):2082-99
references: 17892391
references: Neuroimage. 2009 May 15;46(1):338-42
references: 19457362
references: J Neurophysiol. 2000 Jul;84(1):451-9
references: 10899218
references: Neuron. 2010 Apr 29;66(2):315-26
references: 20435006
references: Science. 2007 Oct 26;318(5850):594-8
references: 17962551
references: Nature. 1999 May 13;399(6732):148-51
references: 10335843
references: Q J Exp Psychol A. 2005 Feb;58(2):193-233
references: 15903115
references: Neuron. 2009 Jun 11;62(5):733-43
references: 19524531
references: Cogn Psychol. 1997 Jun;33(1):5-42
references: 9212720
references: J Neurosci. 2005 Mar 9;25(10):2723-32
references: 15758182
references: Cereb Cortex. 2001 Nov;11(11):1040-6
references: 11590113
references: Brain Res Bull. 2006 Oct 16;70(4-6):263-9
references: 17027761
references: Neuropsychologia. 2005;43(13):1924-37
references: 16168733
references: J Neurosci. 2006 Mar 8;26(10):2745-56
references: 16525054
references: Spat Vis. 1997;10(4):433-6
references: 9176952
references: PLoS One. 2008 Jun 25;3(6):e2520
references: 18575585
references: Neuropsychologia. 2005;43(3):460-72
references: 15707621
references: Neuroimage. 2002 Jun;16(2):484-512
references: 12030833
references: J Cogn Neurosci. 2000 Jan;12(1):110-9
references: 10769309
references: Cortex. 1996 Jun;32(2):241-59
references: 8800613