title: LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.
abstract: We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key histone modifier that participates in the maintenance of pluripotency through the regulation of bivalent domains, a chromatin environment present at the regulatory regions of developmental genes that contains both H3K4 di/trimethylation and H3K27 trimethylation marks. LSD1 occupies the promoters of a subset of developmental genes that contain bivalent domains and are co-occupied by OCT4 and NANOG in human embryonic stem cells, where it controls the levels of H3K4 methylation through its demethylase activity. Thus, LSD1 has a role in maintaining the silencing of several developmental genes in human embryonic stem cells by regulating the critical balance between H3K4 and H3K27 methylation at their regulatory regions.
authors: Center of Regenerative Medicine in Barcelona, Dr. Aiguader, 88, 08003 Barcelona, Spain.
authors: Antonio
authors: A
authors: Adamo
authors: Borja
authors: B
authors: Sesé
authors: Stephanie
authors: S
authors: Boue
authors: Julio
authors: J
authors: Castaño
authors: Ida
authors: I
authors: Paramonov
authors: Maria J
authors: MJ
authors: Barrero
authors: Juan Carlos
authors: JC
authors: Izpisua Belmonte
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