title: Mosapride citrate improves postoperative ileus of patients with colectomy.
abstract: OBJECTIVE
  Postoperative ileus is a transient bowel dysmotility that occurs following many types of operations and is a common complication of gastrointestinal surgery. Mosapride citrate is an agonist of the 5-hydroxytryptamine 4 receptor and accelerates upper gut motility. No study has evaluated its effect on gastrointestinal motility after surgery. The aim of this study was to investigate whether mosapride citrate reduces the duration of postoperative ileus.
  
  
  METHODS
  Thirty patients with colon cancer who underwent colectomy were divided into two groups: the mosapride group and the control group. The mosapride group received mosapride 15 mg by mouth with a minimal amount of water three times a day, starting on postoperative day 1. The control group received only a minimal amount of water on the same schedule. Patients were allowed to resume oral feeding on postoperative day 4. Postoperative time to first flatus and defecation were evaluated, and the amount of food intake was observed. Gastrointestinal motility was recorded on postoperative day 8.
  
  
  RESULTS
  The appearance ratio of interdigestive migrating contractions and the motility index at the antrum and duodenum were significantly higher in the mosapride group than in the control group. The time to first flatus and defecation were significantly shorter in the mosapride group than in the control group. The amount of food intake on postoperative days 6 and 7 was significantly larger in the mosapride group than in the control group.
  
  
  CONCLUSIONS
  Mosapride citrate reduces the duration of postoperative ileus and may improve outcomes after gastrointestinal surgery.
authors: Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, Gunma, 371-8511, Japan. toyomasu@med.gunma-u.ac.jp
authors: Yoshitaka
authors: Y
authors: Toyomasu
authors: Erito
authors: E
authors: Mochiki
authors: Hiroki
authors: H
authors: Morita
authors: Atsushi
authors: A
authors: Ogawa
authors: Mitsuhiro
authors: M
authors: Yanai
authors: Tetsuro
authors: T
authors: Ohno
authors: Takaaki
authors: T
authors: Fujii
authors: Soichi
authors: S
authors: Tsutsumi
authors: Takayuki
authors: T
authors: Asao
authors: Hiroyuki
authors: H
authors: Kuwano
references: Neurogastroenterol Motil. 1998 Aug;10(4):295-303
references: 9697104
references: Eur J Pharmacol. 1999 Nov 3;383(3):281-5
references: 10594320
references: Jpn J Pharmacol. 1999 Apr;79(4):493-6
references: 10361891
references: J Gastroenterol. 2009;44(3):183-9
references: 19214661
references: Am J Surg. 2004 Jun;187(6):728-35
references: 15191866
references: Jpn J Pharmacol. 2002 Dec;90(4):313-20
references: 12501007
references: J Pharmacol Exp Ther. 1997 Dec;283(3):1000-8
references: 9399969
references: Auton Neurosci. 2002 Jul 31;99(1):62-5
references: 12171259
references: Clin Exp Pharmacol Physiol. 2008 Jan;35(1):35-42
references: 18047625
references: Am J Physiol Gastrointest Liver Physiol. 2002 Jul;283(1):G148-56
references: 12065302
references: Neurogastroenterol Motil. 2008 Feb;20(2):169-76
references: 17931343
references: Dis Colon Rectum. 2008 Nov;51(11):1692-5
references: 18584249
references: Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G389-95
references: 12724131
references: J Pharmacol Exp Ther. 1991 May;257(2):781-7
references: 2033519
references: J Pharmacol Exp Ther. 2008 Apr;325(1):190-9
references: 18198343