title: Characterization of full-length MHC class II sequences in Indonesian and Vietnamese cynomolgus macaques.
abstract: In recent years, the use of cynomolgus macaques in biomedical research has increased greatly. However, with the exception of the Mauritian population, knowledge of the MHC class II genetics of the species remains limited. Here, using cDNA cloning and Sanger sequencing, we identified 127 full-length MHC class II alleles in a group of 12 Indonesian and 12 Vietnamese cynomolgus macaques. Forty two of these were completely novel to cynomolgus macaques while 61 extended the sequence of previously identified alleles from partial to full length. This more than doubles the number of full-length cynomolgus macaque MHC class II alleles available in GenBank, significantly expanding the allele library for the species and laying the groundwork for future evolutionary and functional studies.
authors: Wisconsin National Primate Research Center, University of Wisconsin-Madison, USA.
authors: Hannah M
authors: HM
authors: Creager
authors: Ericka A
authors: EA
authors: Becker
authors: Kelly K
authors: KK
authors: Sandman
authors: Julie A
authors: JA
authors: Karl
authors: Simon M
authors: SM
authors: Lank
authors: Benjamin N
authors: BN
authors: Bimber
authors: Roger W
authors: RW
authors: Wiseman
authors: Austin L
authors: AL
authors: Hughes
authors: Shelby L
authors: SL
authors: O'Connor
authors: David H
authors: DH
authors: O'Connor
references: Hum Immunol. 2007 Feb;68(2):135-44
references: 17321904
references: J Virol. 2008 Jan;82(2):859-70
references: 17989178
references: Immunogenetics. 2006 May;58(4):269-82
references: 16572321
references: Comp Med. 2008 Feb;58(1):68-75
references: 19793459
references: J Virol. 2010 Mar;84(5):2304-17
references: 20032177
references: Infect Immun. 2003 Oct;71(10):5831-44
references: 14500505
references: Mol Phylogenet Evol. 2007 Feb;42(2):498-504
references: 16979912
references: Nucleic Acids Res. 2003 Jan 1;31(1):311-4
references: 12520010
references: Immunogenetics. 2002 Jul;54(4):230-9
references: 12136334
references: Immunology. 2004 May;112(1):136-42
references: 15096192
references: Immunogenetics. 2010 Dec;62(11-12):773-80
references: 20882385
references: Exp Mol Pathol. 2000 Feb;68(1):21-8
references: 10640451
references: Immunogenetics. 2010 Mar;62(3):123-36
references: 20094710
references: Stem Cells. 2007 Nov;25(11):2720-9
references: 17690179
references: Immunogenetics. 1992;36(2):71-8
references: 1612647
references: Expert Rev Vaccines. 2007 Jun;6(3):357-68
references: 17542751
references: Immunogenetics. 2010 Mar;62(3):137-47
references: 20131048
references: Immunogenetics. 1993;38(6):462
references: 8406621
references: Science. 2000 Feb 11;287(5455):959-60
references: 10691568
references: J Virol. 2004 May;78(9):4761-75
references: 15078958
references: J Virol. 2001 Nov;75(22):10958-68
references: 11602736
references: J Hered. 2008 May-Jun;99(3):254-64
references: 18334507
references: Tissue Antigens. 2006 Apr;67(4):297-306
references: 16634866
references: Immunogenetics. 2011 Mar;63(3):155-66
references: 21132285
references: Mol Ecol. 2008 Feb;17(4):1009-19
references: 18261045
references: AIDS. 2008 Oct 1;22(15):2038-42
references: 18784467
references: Immunogenetics. 2009 May;61(5):327-39
references: 19337730
references: J Virol. 2010 Apr;84(7):3362-72
references: 20089651
references: Immunogenetics. 2006 May;58(4):259-68
references: 16470376
references: J Infect Dis. 2000 May;181(5):1581-9
references: 10823757
references: J Infect Dis. 2000 Sep;182(3):716-24
references: 10950764
references: J Immunol. 2004 May 15;172(10):6152-7
references: 15128802
references: Toxicol Pathol. 2010 Jun;38(4):642-57
references: 20448082
references: J Virol. 2000 Sep;74(18):8751-6
references: 10954578
references: Mol Biol Evol. 1992 Jul;9(4):599-609
references: 1630302
references: Immunogenetics. 2008 Dec;60(12):737-48
references: 18956179
references: J Med Primatol. 2008 Dec;37(6):311-7
references: 18702628
references: Transplant Proc. 2009 Jan-Feb;41(1):429-30
references: 19249572
references: J Immunol. 2000 Mar 15;164(6):3193-9
references: 10706710
references: J Clin Invest. 2001 Feb;107(4):505-17
references: 11181650
references: Tissue Antigens. 2004 Jun;63(6):529-37
references: 15140028
references: AIDS. 1997 Jul 15;11(9):1196-8
references: 9233476
references: Immunogenetics. 2007 Jun;59(6):449-62
references: 17384942
references: Tuberculosis (Edinb). 2004;84(1-2):93-101
references: 14670350
references: PLoS One. 2008 Jun 11;3(6):e2384
references: 18545705
references: Tissue Antigens. 2008 Oct;72(4):369-78
references: 18828835