title: Hairy cell leukemia: epidemiology, pharmacokinetics of cladribine, and long-term follow-up of subcutaneous therapy.
abstract: Hairy cell leukemia is often reported as a disease of young males. The male predominance is strong, 4:1, but the median age in the Swedish national compulsory cancer registry is similar to that of follicular lymphoma, i.e. 62 years. The overall 6-year survival in the Swedish registry of patients diagnosed since 2000 is 80%, 93% of patients <60 years, and 68% of those >60 years. The yearly risk of secondary cancers is 1.75%. Cladribine is a prodrug which is selectively activated intracellularly. The intracellular initial half-life is 13 h and the terminal half-life is 30 h. Subcutaneous injection once daily is simple and effective due to 100% bioavailability and no local side effects from injection, and self-administration is easy. Long-term follow-up of Scandinavian patients treated with cladribine (mostly as subcutaneous injections) in the early 1990s shows a >80% 15-year survival from cladribine treatment in <60 years of age, but  <50% in older patients. Survival from diagnosis of these patients was similar for those previously treated and untreated.
authors: Department of Laboratory Medicine, Stem Cell Center, Lund University and Department of Hematology, Skåne University Hospital, Lund, Sweden. Gunnar.Juliusson@med.lu.se
authors: Gunnar
authors: G
authors: Juliusson
authors: Henrik
authors: H
authors: Samuelsson