title: Asthma is a distinct comorbid condition in children with sickle cell anemia with elevated total and allergen-specific IgE levels.
abstract: Asthma in children with sickle cell anemia (SCA) is associated with increased morbidity and mortality. However, the definition of asthma in SCA is based on a physician's impression. In a retrospective cohort of children with SCA, relationships between a physician diagnosis of asthma and total and allergen-specific immunoglobulin E levels were evaluated. In children with SCA, elevated total and specific immunoglobulin E levels were significantly associated with a diagnosis of asthma (P<0.05), further supporting the concept that asthma is a separate comorbid condition of SCA.
authors: Department of Pediatrics, Washington University School of Medicine, St-Louis, MO, USA.
authors: Jerlinda G C
authors: JG
authors: Ross
authors: Francoise
authors: F
authors: Bernaudin
authors: Robert C
authors: RC
authors: Strunk
authors: Annie
authors: A
authors: Kamdem
authors: Cecile
authors: C
authors: Arnaud
authors: Martine
authors: M
authors: Hervé
authors: Christophe
authors: C
authors: Delacourt
authors: Michael R
authors: MR
authors: DeBaun
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