title: Circulating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndrome.
abstract: Circulating microRNAs (miRNAs) are potential biomarkers for cancer. We examined plasma levels of 2 miRNAs, let-7a and miR-16, in 50 patients with myelodysplastic syndrome (MDS) and 76 healthy persons using quantitative real-time PCR. Circulating levels of both miRNAs were similar among healthy controls but were significantly lower in MDS patients (P = .001 and P < .001, respectively). The distributions of these 2 miRNA levels were bimodal in MDS patients, and these levels were significantly associated with their progression-free survival and overall survival (both P < .001 for let-7a; P < .001 and P = .001 for miR-16). This association persisted even after patients were stratified according to the International Prognostic Scoring System. Multivariate analysis revealed that let-7a level was a strong independent predictor for overall survival in this patient cohort. These findings suggest that let-7a and miR-16 plasma levels can serve as noninvasive prognostic markers in MDS patients.
authors: Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77054, USA. zzuo@mdanderson.org
authors: Zhuang
authors: Z
authors: Zuo
authors: George A
authors: GA
authors: Calin
authors: Henrique M
authors: HM
authors: de Paula
authors: L Jeffrey
authors: LJ
authors: Medeiros
authors: Michael H
authors: MH
authors: Fernandez
authors: Masayoshi
authors: M
authors: Shimizu
authors: Guillermo
authors: G
authors: Garcia-Manero
authors: Carlos E
authors: CE
authors: Bueso-Ramos
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