title: Enoyl coenzyme A hydratase 1 is an important factor in the lymphatic metastasis of tumors.
abstract: We have previously demonstrated that enoyl coenzyme A hydratase 1 (Ech1) is involved in the lymphatic metastasis of tumors. In this study, RNAi was used to investigate the role of Ech1 in Hca-F, a hepatocarcinoma cell line with high rates of lymphatic metastasis. The downregulation of Ech1 inhibited proliferation of the Hca-F cells, increased the ratio of Hca-F cells in S phase to G(1) phase and decreased the adhesion and migration capacities of Hca-F cells. A higher expression level of Ech1 was confirmed in tissue from patients with gastric carcinoma (GC) with lymph node metastases (LNM), indicating the clinical association with tumor metastasis. The results indicate that Ech1 is a critical factor in the development of lymphatic metastasis in these tumors.
authors: Department of Pathology, Dalian Medical University, Dalian, Dalian 116044, China.
authors: Jun
authors: J
authors: Zhang
authors: Meiying
authors: M
authors: Song
authors: Jingwen
authors: J
authors: Wang
authors: Mingzhong
authors: M
authors: Sun
authors: Bo
authors: B
authors: Wang
authors: Rongkuan
authors: R
authors: Li
authors: Yuhong
authors: Y
authors: Huang
authors: Li
authors: L
authors: Hou
authors: Yanling
authors: Y
authors: Jin
authors: Mei
authors: M
authors: Wang
authors: Jianwu
authors: J
authors: Tang