title: Adjuvant chemoradiation after laparoscopically assisted vaginal radical hysterectomy (LARVH) in patients with cervical cancer: oncologic outcome and morbidity.
abstract: OBJECTIVE
  Compared to laparotomic surgery, laparoscopically assisted radical vaginal hysterectomy (LARVH) offers decreased blood loss during surgery and faster convalescence of the patient postoperatively, while at the same time delivering similar oncologic results. However, there is no data on outcome and toxicity of LARVH followed by (chemo)radiation.
  
  
  METHODS
  A total of 55 patients (range 28-78 years) with cervical cancer on FIGO stages IB1-IIIA (Tables 1 and 2) with risk factors were submitted to either external beam radiotherapy alone [EBRT, n = 8 (14%), including paraaortic irradiation, n = 4 (2.2%); EBRT and brachytherapy (BT), n = 33 (60%); BT alone, n = 14 (25.5%)] or chemoradiation after LARVH.
  
  
  RESULTS
  At a median follow-up of 4.4 years, the 5-year disease-free survival (DFS) was 81.8% with 84.5% overall survival (OS). Acute grade 3 side effects were seen in 4 patients. These were mainly gastrointestinal (GI) and genitourinary (GU) symptoms. Grade 4 side effects were not observed.
  
  
  CONCLUSIONS
  With similar oncologic outcome data and mostly mild side effects, LARVH followed by (chemo)radiation is a valid alternative in the treatment of cervical cancer patients.
authors: Department of Radiooncology, Charité - University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany.
authors: Arne
authors: A
authors: Gruen
authors: Thabea
authors: T
authors: Musik
authors: Christhardt
authors: C
authors: Köhler
authors: Jürgen
authors: J
authors: Füller
authors: Thomas
authors: T
authors: Wendt
authors: Carmen
authors: C
authors: Stromberger
authors: Volker
authors: V
authors: Budach
authors: Achim
authors: A
authors: Schneider
authors: Simone
authors: S
authors: Marnitz
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