title: Targeted single-shot methods for diffusion-weighted imaging in the kidneys.
abstract: OBJECTIVE
  To investigate the feasibility of combining the inner-volume-imaging (IVI) technique with single-shot diffusion-weighted (DW) spin-echo echo-planar imaging (SE-EPI) and DW-SPLICE (split acquisition of fast spin-echo) sequences for renal DW imaging.
  
  
  METHODS
  Renal DWI was performed in 10 healthy volunteers using single-shot DW-SE-EPI, DW-SPLICE, targeted-DW-SE-EPI, and targeted-DW-SPLICE. We compared the quantitative diffusion measurement accuracy and image quality of these targeted-DW-SE-EPI and targeted DW-SPLICE methods with conventional full field of view (FOV) DW-SE-EPI and DW-SPLICE measurements in phantoms and normal volunteers.
  
  
  RESULTS
  Compared with full FOV DW-SE-EPI and DW-SPLICE methods, targeted-DW-SE-EPI and targeted-DW-SPLICE approaches produced images of superior overall quality with fewer artifacts, less distortion, and reduced spatial blurring in both phantom and volunteer studies. The apparent diffusion coefficient (ADC) values measured with each of the four methods were similar and in agreement with previously published data. There were no statistically significant differences between the ADC values and intravoxel incoherent motion (IVIM) measurements in the kidney cortex and medulla using single-shot DW-SE-EPI, targeted-DW-EPI, and targeted-DW-SPLICE (P > 0.05).
  
  
  CONCLUSIONS
  Compared with full-FOV DWI methods, targeted-DW-SE-EPI and targeted-DW-SPLICE techniques reduced image distortion and artifacts observed in the single-shot DW-SE-EPI images, reduced blurring in DW-SPLICE images, and produced comparable quantitative DW and IVIM measurements to those produced with conventional full-FOV approaches.
authors: Department of Biomedical Engineering, Northwestern University Chicago, Illinois, USA.
authors: Ning
authors: N
authors: Jin
authors: Jie
authors: J
authors: Deng
authors: Longjiang
authors: L
authors: Zhang
authors: Zhuoli
authors: Z
authors: Zhang
authors: Guangming
authors: G
authors: Lu
authors: Reed A
authors: RA
authors: Omary
authors: Andrew C
authors: AC
authors: Larson
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