title: A new twist on the PYRIN Mediterranean coast.
abstract: Familial Mediterranean fever is caused by mutations of the PYRIN protein. Chae et al. (2011) provide evidence for a ASC protein-dependent pathway of caspase-1 activation in which gain-of-function PYRIN mutations lead to IL-1β cytokine overproduction and inflammatory disease.
authors: Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors: Luigi
authors: L
authors: Franchi
authors: Gabriel
authors: G
authors: Núñez