title: Modelling effectiveness of herd level vaccination against Q fever in dairy cattle.
abstract: Q fever is a worldwide zoonosis caused by the bacterium Coxiella burnetii. The control of this infection in cattle is crucial: infected ruminants can indeed encounter reproductive disorders and represent the most important source of human infection. In the field, vaccination is currently advised in infected herds but the comparative effectiveness of different vaccination protocols has never been explored: the duration of the vaccination programme and the category of animals to be vaccinated have to be determined. Our objective was to compare, by simulation, the effectiveness over 10 years of three different vaccination strategies in a recently infected dairy cattle herd.A stochastic individual-based epidemic model coupled with a model of herd demography was developed to simulate three temporal outputs (shedder prevalence, environmental bacterial load and number of abortions) and to calculate the extinction rate of the infection. For all strategies, the temporal outputs were predicted to strongly decrease with time at least in the first years of vaccination. However, vaccinating only three years was predicted inadequate to stabilize these dynamic outputs at a low level. Vaccination of both cows and heifers was predicted as being slightly more effective than vaccinating heifers only. Although the simulated extinction rate of the infection was high for both scenarios, the outputs decreased slower when only heifers were vaccinated.Our findings shed new light on vaccination effectiveness related to Q fever. Moreover, the model can be further modified for simulating and assessing various Q fever control strategies such as environmental and hygienic measures.
authors: INRA, UMR1300 Bio-agression, Epidémiologie et Analyse de Risque, Atlanpole La Chantrerie, BP 40706, 44307 Nantes, France. aurelie.courcoul@oniris-nantes.fr.
authors: Aurélie
authors: A
authors: Courcoul
authors: Lenny
authors: L
authors: Hogerwerf
authors: Don
authors: D
authors: Klinkenberg
authors: Mirjam
authors: M
authors: Nielen
authors: Elisabeta
authors: E
authors: Vergu
authors: François
authors: F
authors: Beaudeau
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