title: Ultrasound and MRI of fetuses with ventriculomegaly: can cortical development be used to predict postnatal outcome?
abstract: OBJECTIVE
  The purpose of this study was to assess the conspicuity of brain cortical maturation with sonography and MRI of fetuses referred because of ventriculomegaly and to determine whether sulcal visualization can be used to predict postnatal outcome.
  
  
  METHODS
  Women with 374 fetuses referred because of ventriculomegaly underwent sonography and MRI. Four to six radiologists rated visualization of 19 fissures or sulci. Majority opinion regarding sulcal visualization was compared among fetuses categorized by CNS abnormality: normal, isolated ventriculomegaly, and ventriculomegaly with additional CNS abnormalities. Live-born infants were categorized as having normal or abnormal development. Logistic regression analysis was used to correlate sulcal visualization and postnatal development. A subanalysis was performed with fetuses who had been classified prenatally as having a normal brain or isolated ventriculomegaly.
  
  
  RESULTS
  Cortical sulci were visualized more frequently and at an earlier gestational age with MRI than with ultrasound. In the entire cohort, the odds ratio of normal development ranged from 3.1 to 10.0 whenever the calcarine, parietooccipital, cingulate, superior temporal, precentral, or postcentral sulcus was seen on MR images. In fetuses categorized as having a normal brain or having isolated ventriculomegaly, the odds ratio of normal development ranged from 3.5 to 9.0 whenever the parietooccipital, cingulate, or superior temporal sulcus was seen.
  
  
  CONCLUSIONS
  Visualization of the sulci in fetal brains depends on the imaging modality used and the gestational age at imaging. Information regarding sulcal visualization may aid in counseling patients carrying fetuses with ventriculomegaly.
authors: Harvard Medical School, Boston, MA, USA.
authors: Yi
authors: Y
authors: Li
authors: Judy A
authors: JA
authors: Estroff
authors: Tejas S
authors: TS
authors: Mehta
authors: Richard L
authors: RL
authors: Robertson
authors: Caroline D
authors: CD
authors: Robson
authors: Tina Y
authors: TY
authors: Poussaint
authors: Henry A
authors: HA
authors: Feldman
authors: Janet
authors: J
authors: Ware
authors: Deborah
authors: D
authors: Levine
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