title: [The cyclin A, B1, D1 and E expression in advanced non-small cell lung cancer--stages IIIB-IV (preliminary report)].
abstract: Lung cancer is the leading cause of cancer death in the majority of developed countries. Uncontrolled cell proliferation is the hallmark of malignant tumours. Cyclins play an important role in cell cycle regulation. The aim of this study was to evaluate the expression of cyclins A, B1, D1 and E in advanced non-small cell lung cancer (stages IIIB-IV) with its prognostic significance.
  
  
  METHODS
  An immunohistochemical assessment of cyclins A, B1, D1 and E expression was performed in the paraffin-embedded tumor tissues of 19 patients (9 men and 10 women). The mean was age 59 +/- 6.64 years. 9 patients were in IIIB and 10 in IV. The 2-years survival rate was evaluated.
  
  
  RESULTS
  We showed positive cyclin A expression in 13 tumor tissue specimens (68%), cyclin B1 in 3 (16%), cyclin D1 in 9 (47%) and cyclin E in 7 (37%). We analyzed the prognostic value of examinated cyclins in all NSCLC patients and separately in patients with squamous cell lung cancer and adenocarcinoma and in patients in stage IIIB and IV, but we have no found any correlations. We did not find also any differences in examinated cyclins expression depending on stages nor different histopathological types.
  
  
  CONCLUSIONS
  We did not observe prognostic value of cyclins A, B1, D1 or E expression in advanced non-small cell lung cancer.
authors: Akademia Medyczna we Wrocławiu, Katedra i Klinika Pulmonologii i Nowotworów Płuc. mika113@tlen.pl
authors: Monika
authors: M
authors: Kosacka
authors: Paweł
authors: P
authors: Piesiak
authors: Irena
authors: I
authors: Porebska
authors: Anna
authors: A
authors: Korzeniewska
authors: Renata
authors: R
authors: Jankowska