title: Indexes of β-cell function from the oral glucose tolerance test can modestly predict pancreatic β-cell area in Korean.
abstract: OBJECTIVE
  Pancreatic β-cell function indexes have been suggested using the oral glucose tolerance test (OGTT). Here, we investigated whether β-cell function index from the OGTT reflects pancreatic β-cell area in Korean patients.
  
  
  METHODS
  The study consisted of 45 patients who underwent pancreatectomies. Before operation, a 75-g OGTT was performed. Immunohistochemical staining was performed, and indexes of β-cell function from the OGTT data were compared with the pancreatic β-cell area.
  
  
  RESULTS
  The β-cell area of the pancreas was 1.07 ± 0.33% in the normal glucose tolerance group, 1.71 ± 0.85% in the pre-diabetes group (impaired glucose tolerance and impaired fasting glucose), and 1.08 ± 0.57% in the diabetes group. The β-cell area of the pre-diabetes group was significantly higher than that of the diabetes group. Pancreatic β-cell area showed a significant correlation with a homeostasis model assessment of β-cell function (r=0.358, P=0.016), disposition index (r=0.336, P=0.024), fasting glucose (r=-0.359, P=0.015), and the C-peptide/glucose 30 min ratio (r=0.319, P=0.035).
  
  
  CONCLUSIONS
  Some parameters of β-cell function from the OGTT showed a significant relationship with the β-cell area of pancreas.
authors: Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, #50, Irwon-dong, Gangnam-gu, 135-710 Seoul, Republic of Korea.
authors: Soo Kyoung
authors: SK
authors: Kim
authors: Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, #50, Irwon-dong, Gangnam-gu, 135-710 Seoul, Republic of Korea.
authors: Jae Hyeon
authors: JH
authors: Kim
authors: Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, #50, Irwon-dong, Gangnam-gu, 135-710 Seoul, Republic of Korea.
authors: Ji Young
authors: JY
authors: Park
authors: Samsung Biomedical Research Institute, Seoul, Republic of Korea.
authors: Hee Sung
authors: HS
authors: No
authors: Department of Pathology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Kee-Taek
authors: KT
authors: Jang
authors: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Jin Seok
authors: JS
authors: Heo
authors: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Seong Ho
authors: SH
authors: Choi
authors: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Dong Wook
authors: DW
authors: Choi
authors: Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, #50, Irwon-dong, Gangnam-gu, 135-710 Seoul, Republic of Korea. Electronic address: kw1234@skku.edu.
authors: Kwang-Won
authors: KW
authors: Kim