title: Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models.
abstract: BACKGROUND
  Different regions of the striatum may have distinct roles in acute intoxication, alcohol seeking, dependence, and withdrawal.
  
  
  METHODS
  The recent advances are reviewed and discussed in our understanding of the role of the dorsolateral striatum (DLS), dorsomedial striatum (DMS), and ventral striatum in behavioral responses to alcohol, including alcohol craving in abstinent alcoholics, and alcohol consumption and withdrawal in rat, mouse, and nonhuman primate models.
  
  
  RESULTS
  Reduced neuronal activity as well as dysfunctional connectivity between the ventral striatum and the dorsolateral prefrontal cortex is associated with alcohol craving and impairment of new learning processes in abstinent alcoholics. Within the DLS of mice and nonhuman primates withdrawn from alcohol after chronic exposure, glutamatergic transmission in striatal projection neurons is increased, while GABAergic transmission is decreased. Glutamatergic transmission in DMS projection neurons is also increased in ethanol withdrawn rats. Ex vivo or in vivo ethanol exposure and withdrawal causes a long-lasting increase in NR2B subunit-containing NMDA receptor activity in the DMS, contributing to ethanol drinking. Analyses of neuronal activation associated with alcohol withdrawal and site-directed lesions in mice implicate the rostroventral caudate putamen, a ventrolateral segment of the DMS, in genetically determined differences in risk for alcohol withdrawal involved in physical association of the multi-PDZ domain protein, MPDZ, with 5-HT(2C) receptors and/or NR2B.
  
  
  CONCLUSIONS
  Alterations of dopaminergic, glutamatergic, and GABAergic signaling within different regions of the striatum by alcohol is critical for alcohol craving, consumption, dependence, and withdrawal in humans and animal models.
authors: Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA. hdn_2001@yahoo.com
authors: Gang
authors: G
authors: Chen
authors: Verginia C
authors: VC
authors: Cuzon Carlson
authors: Jun
authors: J
authors: Wang
authors: Anne
authors: A
authors: Beck
authors: Andreas
authors: A
authors: Heinz
authors: Dorit
authors: D
authors: Ron
authors: David M
authors: DM
authors: Lovinger
authors: Kari J
authors: KJ
authors: Buck
references: Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3113-23
references: 18653439
references: Biol Psychiatry. 2007 Mar 15;61(6):765-75
references: 17027930
references: Alcohol Clin Exp Res. 1999 Apr;23(4):611-6
references: 10235296
references: Crit Rev Neurobiol. 2000;14(1):69-89
references: 11253956
references: Brain Res. 2007 Apr 13;1141:65-73
references: 17289000
references: Neuroimage. 2007 Apr 1;35(2):787-94
references: 17291784
references: Alcohol Clin Exp Res. 2001 Aug;25(8):1087-97
references: 11505038
references: Neurosci Lett. 2010 Jan 22;469(2):251-5
references: 20004702
references: J Neurochem. 2007 Dec;103(6):2200-11
references: 17986236
references: J Neurochem. 2008 Jul;106(2):957-68
references: 18435828
references: Am J Psychiatry. 2005 Aug;162(8):1515-20
references: 16055774
references: Addict Biol. 2009 Jan;14(1):108-18
references: 18855799
references: Drug Alcohol Depend. 1995 May;38(2):95-137
references: 7671769
references: Alcohol. 2009 Feb;43(1):35-43
references: 19185208
references: Neuroscientist. 2004 Aug;10(4):325-36
references: 15271260
references: Trends Neurosci. 2003 Apr;26(4):184-92
references: 12689769
references: Science. 1989 Mar 31;243(4899):1721-4
references: 2467382
references: J Neurosci. 2010 Jun 2;30(22):7749-53
references: 20519550
references: Alcohol Clin Exp Res. 2005 Nov;29(11):1939-48
references: 16340450
references: Biol Psychiatry. 2008 Aug 1;64(3):192-202
references: 18374900
references: Cereb Cortex. 2009 Aug;19(8):1844-56
references: 19068490
references: Pharmacol Rev. 2009 Mar;61(1):98-114
references: 19270242
references: Behav Pharmacol. 1994 Aug;5(4 And 5):425-440
references: 11224295
references: Alcohol Clin Exp Res. 2008 Feb;32(2):197-208
references: 18162080
references: Prog Drug Res. 2000;54:152-89
references: 10857388
references: Ann N Y Acad Sci. 1992 Jun 28;654:513-6
references: 1632615
references: J Biol Chem. 2001 Apr 20;276(16):12974-82
references: 11150294
references: Biol Psychiatry. 2005 Nov 15;58(10):779-86
references: 16018986
references: Aust N Z J Psychiatry. 2006 Feb;40(2):171-8
references: 16476136
references: Hum Neurobiol. 1986;5(3):159-68
references: 2876974
references: Behav Neurosci. 2005 Aug;119(4):911-25
references: 16187819
references: Neuron. 2004 Aug 19;43(4):563-74
references: 15312654
references: J Comp Neurol. 1985 Jun 22;236(4):454-76
references: 2414339
references: Neuron. 1994 Mar;12(3):529-40
references: 7512349
references: Neuropsychopharmacology. 2010 Jan;35(1):48-69
references: 19776734
references: Alcohol. 2009 Sep;43(6):411-20
references: 19801271
references: Am J Psychiatry. 2004 Oct;161(10):1783-9
references: 15465974
references: Neuropsychopharmacology. 2009 Oct;34(11):2420-9
references: 19553918
references: Curr Opin Neurobiol. 2001 Jun;11(3):327-35
references: 11399431
references: Methods. 2010 Mar;50(3):199-204
references: 19364532
references: Alcohol Clin Exp Res. 2004 Dec;28(12):1829-38
references: 15608599
references: Br J Pharmacol. 2008 May;154(2):299-315
references: 18311194
references: Neurosci Lett. 1984 Jun 1;47(1):15-22
references: 6087218
references: Eur Psychiatry. 2002 Mar;17(1):9-16
references: 11918987
references: Neuron. 2005 Jun 2;46(5):745-60
references: 15924861
references: J Neurosci. 2007 Jun 6;27(23):6313-9
references: 17554005
references: J Neurosci. 2010 Jul 28;30(30):10187-98
references: 20668202
references: BMC Biol. 2009 Oct 27;7:70
references: 19874574
references: Alcohol Clin Exp Res. 2009 Apr;33(4):712-21
references: 19175764
references: J Neurosci. 2003 May 1;23(9):3623-32
references: 12736333
references: J Neurosci. 2007 May 16;27(20):5506-14
references: 17507572
references: Brain Res. 1985 Feb 18;327(1-2):307-11
references: 3986508
references: J Neurosci. 2001 Aug 15;21(16):RC159
references: 11459880
references: Nat Neurosci. 2004 Jul;7(7):699-700
references: 15208631
references: Nat Rev Neurosci. 2006 Jun;7(6):464-76
references: 16715055
references: J Neurosci. 2007 Mar 28;27(13):3593-602
references: 17392475
references: Arch Gen Psychiatry. 1996 Dec;53(12):1123-8
references: 8956678
references: Genes Brain Behav. 2010 Oct;9(7):768-76
references: 20608999
references: Addiction. 2010 Oct;105(10):1741-9
references: 20670348
references: Trends Pharmacol Sci. 2003 Nov;24(11):566-73
references: 14607079
references: J Neurophysiol. 2000 Sep;84(3):1422-9
references: 10980015
references: Neuron. 2003 Apr 24;38(2):329-37
references: 12718865
references: Curr Opin Neurobiol. 1996 Apr;6(2):228-36
references: 8725965
references: J Neurosci. 2008 Sep 24;28(39):9840-9
references: 18815268
references: Eur J Neurosci. 1998 May;10(5):1716-22
references: 9751143
references: Nat Neurosci. 2005 Nov;8(11):1481-9
references: 16251991
references: J Neurosci. 1997 May 15;17(10):3946-55
references: 9133412
references: J Biol Chem. 2003 Jun 13;278(24):21576-83
references: 12682077
references: J Neurosci. 2002 May 1;22(9):3730-8
references: 11978849
references: Int Rev Neurobiol. 1996;39:283-367
references: 8894851
references: Psychopharmacology (Berl). 2009 Sep;205(4):529-64
references: 19455309
references: J Neurosci. 2008 Dec 10;28(50):13384-9
references: 19074011
references: J Comp Neurol. 1990 Jul 15;297(3):359-76
references: 1697864
references: Behav Brain Res. 2011 Mar 17;218(1):152-7
references: 20974184
references: Brain Res Brain Res Rev. 1993 Sep-Dec;18(3):247-91
references: 8401595
references: Science. 1997 Mar 14;275(5306):1593-9
references: 9054347
references: Nat Genet. 1998 Feb;18(2):155-8
references: 9462745
references: Alcohol Clin Exp Res. 1996 Dec;20(9):1594-8
references: 8986209
references: Biol Psychiatry. 2009 Oct 15;66(8):734-42
references: 19560123
references: Nat Rev Neurosci. 2004 Apr;5(4):317-28
references: 15034556
references: Psychopharmacology (Berl). 2004 Sep;175(3):296-302
references: 15127179
references: J Neurosci. 2004 Feb 18;24(7):1594-603
references: 14973247