title: Testosterone increases: sodium reabsorption, blood pressure, and renal pathology in female spontaneously hypertensive rats on a high sodium diet.
abstract: Estrogen (E) and testosterone (T) are important in the sexually dimorphic pattern of blood pressure (BP) development. The goal was to examine the effects of endogenous E and exogenous T in the development of hypertension in female spontaneously hypertensive rats (SHR) on a high sodium diet. Female SHR (N = 27, 5-week) were divided into four groups: (1) control (n = 8), (2) ovariectomized (OVX, n = 26), (3) testosterone implants with intact ovaries (T, n = 6), and (4) ovariectomized + testosterone implants (OVX+T, n = 7). T was given immediately after OVX and replaced every two weeks and they were fed a 3% NaCl diet. BP was measured weekly and plasma norepinephrine (NE) analyzed by HPLC. OVX+T females exhibited the greatest elevation in BP (190 ± 4.0 mmHg) compared to controls at 15 weeks of age (140 ± 3.4 mmHg, P < .001) and a pattern of hypertension development similar to that of male SHR. Females with T treatment showed evidence of glomerulosclerosis. In conclusion, T accelerated the development of hypertension similar to the BP pattern observed in males; the presence of ovaries attenuated the T induced increase in BP; T increased renal sodium reabsorption, and T increased glomerulosclerosis.
authors: Department of Biology, The University of Akron, Akron, OH 44325-3908, USA.
authors: Bei
authors: B
authors: Liu
authors: Daniel
authors: D
authors: Ely
references: Regul Pept. 2005 Jan 15;124(1-3):7-17
references: 15544836
references: Hypertension. 2001 May;37(5):1199-208
references: 11358929
references: Clin Exp Hypertens. 1993 Jan;15(1):153-70
references: 8385524
references: Clin Exp Hypertens A. 1983;5(9):1559-87
references: 6685587
references: Am J Physiol. 1997 Dec;273(6):R1908-15
references: 9435644
references: J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):363-6
references: 12943723
references: Hypertension. 1997 Jun;29(6):1351-6
references: 9180640
references: J Hypertens. 1988 Apr;6(4):329-32
references: 3379300
references: Circ Res. 1995 Nov;77(5):936-42
references: 7554147
references: J Am Coll Cardiol. 1998 Nov;32(5):1331-5
references: 9809944
references: Hypertension. 1997 Feb;29(2):613-8
references: 9040447
references: J Hypertens. 1987 Aug;5(4):383-95
references: 3312406
references: Proc Natl Acad Sci U S A. 1994 May 24;91(11):5212-6
references: 7515189
references: Hypertension. 1990 Jun;15(6 Pt 1):547-59
references: 1971810
references: Blood Press. 2000;9(4):227-38
references: 11055476
references: Hypertension. 1995 Jul;26(1):208-12
references: 7607726
references: J Am Soc Nephrol. 1993 May;3(11):1835-8
references: 8329677
references: Arterioscler Thromb Vasc Biol. 1995 May;15(5):562-70
references: 7749870
references: J Hypertens. 1994 Jul;12(7):769-74
references: 7963505
references: BMC Physiol. 2008 Mar 26;8:5
references: 18366771
references: Hypertension. 2000 Feb;35(2):587-94
references: 10679502
references: Hypertension. 1982 Nov-Dec;4(6):753-63
references: 6754600
references: JAMA. 2003 Jul 9;290(2):199-206
references: 12851274
references: Kidney Int. 2004 May;65(5):1774-81
references: 15086916
references: Circ Res. 1975 Jul;37(1):101-10
references: 1149180
references: Hypertension. 1998 Jan;31(1 Pt 2):435-9
references: 9453341
references: Steroids. 2010 Nov;75(11):747-53
references: 19914267
references: Circ Res. 1978 Jan;42(1):126-35
references: 338192
references: Life Sci. 2000 Dec 15;68(4):417-29
references: 11205891
references: Hypertension. 2003 Mar;41(3 Pt 2):830-3
references: 12624004
references: Jpn J Pharmacol. 1994 Dec;66(4):439-44
references: 7723220
references: Hypertension. 1996 Oct;28(4):576-82
references: 8843881
references: Endocr Rev. 2003 Jun;24(3):313-40
references: 12788802
references: J Lab Clin Med. 1977 Dec;90(6):997-1003
references: 925488
references: Clin Exp Pharmacol Physiol. 1999 Feb;26(2):127-31
references: 10065333
references: Hypertension. 1999 Jul;34(1):151-9
references: 10406839
references: Hypertension. 1993 Jun;21(6 Pt 2):1071-5
references: 8505094
references: FASEB J. 1988 Apr;2(7):2241-51
references: 3280378
references: Kidney Int. 1997 Jun;51(6):1719-28
references: 9186859
references: Blood Press. 1999;8(5-6):300-7
references: 10803491
references: Hypertension. 1991 Jun;17(6 Pt 2):1104-10
references: 2045156
references: J Hypertens. 1989 Sep;7(9):721-6
references: 2529310
references: J Appl Physiol (1985). 2002 Feb;92(2):567-71
references: 11796665
references: Life Sci. 1991;48(1):85-96
references: 1986184
references: J Clin Endocrinol Metab. 2005 Jul;90(7):3847-53
references: 15827095
references: Eur J Pharmacol. 1972 Dec;20(3):329-40
references: 4643454
references: Hypertension. 1998 Nov;32(5):880-5
references: 9822448
references: Neurochem Int. 1985;7(4):667-74
references: 20492973
references: Arch Sex Behav. 1996 Dec;25(6):589-600
references: 8931882
references: Jpn Circ J. 1963 Mar;27:282-93
references: 13939773
references: Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1793-801
references: 11247793
references: Hypertension. 2008 Nov;52(5):818-27
references: 18852389