title: [Association of IL-1beta gene -31T/C polymorphism with chronic rhinosinusitis].
abstract: OBJECTIVE
  To investigate the relationship between polymorphism of IL-1beta gene 31T/C and chronic rhinosinusitis.
  
  
  METHODS
  One hundred and twenty-three patients with chronic rhinosinusitis and 239 healthy controls were collected to determine the genotypes by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  There was significant difference in genotype and allelic frequencies between the CRS and control group (P < 0.05). -31CC genotype was an independent risk factor with CRS (P < 0.05, OR = 1.639). There was no significant difference in TIgE and ECP among these genotypes (P > 0.05).
  
  
  CONCLUSIONS
  IL-1beta gene 31CC genotype may be an independent risk factor with chronic rhinosinusitis.
authors: Department of Otolaryngology, Ruijin Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
authors: Nijun
authors: N
authors: Chen
authors: Peihua
authors: P
authors: Ni
authors: Changping
authors: C
authors: Cai
authors: Shili
authors: S
authors: Wang