title: Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently.
abstract: OBJECTIVE
  Fibroblast growth factor (FGF21) has beneficial effects on lipolysis. Highly sensitive C-reactive protein (hs-CRP) is a predictor of type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). This study aimed to determine the levels of serum FGF21 and hs-CRP in newly diagnosed type 2 diabetes patients with and without NAFLD, and further explored the correlation between FGF21 with hs-CRP in newly diagnosed type 2 DM.
  
  
  METHODS
  69 patients with newly diagnosed type 2 DM and 30 normal subjects were included in the study. FGF21 and hs-CRP were measured by ELISA kits. The severity of NAFLD was measured by ultrasound.
  
  
  RESULTS
  Serum FGF21 in newly diagnosed type 2 DM with NAFLD group were significantly increased (p<0.01). There was no difference for the FGF21 level in normal control group and newly diagnosed type 2 DM without NFALD group. In type 2 DM group, the FGF21 level was positively correlated with hsCRP (r=0.417, p<0.001). In multiple stepwise regression models, only hsCRP was a significantly independent determinant for serum FGF21.
  
  
  CONCLUSIONS
  Serum levels of FGF21 are closely related to liver steatosis in newly diagnosed type 2 DM patients.
authors: Department of Endocrinology and Metabolism, Shanghai Minhang District Central Hospital, Shanghai 201100, China.
authors: Xuesong
authors: X
authors: Li
authors: Xiaofang
authors: X
authors: Fan
authors: Fengdong
authors: F
authors: Ren
authors: Yu
authors: Y
authors: Zhang
authors: Chunfang
authors: C
authors: Shen
authors: Guoguang
authors: G
authors: Ren
authors: Jue
authors: J
authors: Sun
authors: Ning
authors: N
authors: Zhang
authors: Weiqing
authors: W
authors: Wang
authors: Guang
authors: G
authors: Ning
authors: Jialin
authors: J
authors: Yang