title: Fully automated synthesis of the M₁ receptor agonist [¹¹C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system.
abstract: A fully automated and GMP compatible synthesis has been developed to reliably label the M₁ receptor agonist GSK1034702 with carbon-11. Stille reaction of the trimethylstannyl precursor with [¹¹C]methyl iodide afforded [¹¹C]GSK1034702 in an estimated 10 ± 3% decay corrected yield. This method utilises the commercially available modular laboratory equipment and provides high purity [¹¹C]GSK1034702 in a formulation suitable for human use.
authors: GlaxoSmithKline, Clinical Imaging Centre, Imperial College London, Hammersmith Hospital, London, UK. Mickael.x.huiban@gsk.com
authors: Mickael
authors: M
authors: Huiban
authors: Sabina
authors: S
authors: Pampols-Maso
authors: Jan
authors: J
authors: Passchier