title: Lack of association of tumor-associated macrophages with clinical outcome in patients with classical Hodgkin's lymphoma.
abstract: BACKGROUND
  A recent study demonstrated that an increased number of CD68+ macrophages were correlated with primary treatment failure, shortened progression-free survival (PFS) and disease-specific survival (DSS) in patients with classical Hodgkin's lymphoma (cHL).
  
  
  METHODS
  The aim of the present study was to verify the relationship between the number of CD68+ and CD163+ macrophages with clinical outcomes in a cohort of 265 well-characterized patients with cHL treated uniformly with the standard doxorubicin, bleomycin, vinblastine and dacarbazine chemotherapy regimen. Two pairs of hematopathologists carried out independent pathological evaluations of tissue microarray slides.
  
  
  RESULTS
  There were no associations between clinical characteristics and the expression of CD68 or CD163. However, higher levels of CD68 and CD163 expression were correlated with the presence of Epstein-Barr virus-positive Hodgkin tumor cells (P = 0.01 and 0.037, respectively). The expression of CD68 or CD163 was not associated with either the PFS or the DSS.
  
  
  CONCLUSIONS
  CD68 and CD163 expression require further evaluation before their use can be recommended for prognostic stratification of patients with cHL.
authors: Department of Hematology, Postgraduate Program in Internal Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors: D
authors: D
authors: Azambuja
authors: Department of Pathology, Stanford University School of Medicine, Stanford, USA.
authors: Y
authors: Y
authors: Natkunam
authors: Departments of Medicine and Pathology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors: I
authors: I
authors: Biasoli
authors: Department of Medicine, Division of Hematology-Oncology and Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, USA.
authors: I S
authors: IS
authors: Lossos
authors: Department of Pathology, Stanford University School of Medicine, Stanford, USA.
authors: M W
authors: MW
authors: Anderson
authors: Departments of Medicine and Pathology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors: J C
authors: JC
authors: Morais
authors: Departments of Medicine and Pathology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: spector@ufrj.br.
authors: N
authors: N
authors: Spector
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