title: sLORETA allows reliable distributed source reconstruction based on subdural strip and grid recordings.
abstract: Source localization based on invasive recordings by subdural strip and grid electrodes is a topic of increasing interest. This simulation study addresses the question, which factors are relevant for reliable source reconstruction based on sLORETA. MRI and electrode positions of a patient undergoing invasive presurgical epilepsy diagnostics were the basis of sLORETA simulations. A boundary element head model derived from the MRI was used for the simulation of electrical potentials and source reconstruction. Focal dipolar sources distributed on a regular three-dimensional lattice and spatiotemporal distributed patches served as input for simulation. In addition to the distance between original and reconstructed source maxima, the activation volume of the reconstruction and the correlation of time courses between the original and reconstructed sources were investigated. Simulations were supplemented by the localization of the patient's spike activity. For noise-free simulated data, sLORETA achieved results with zero localization error. Added noise diminished the percentage of reliable source localizations with a localization error ≤15 mm to 67.8%. Only for source positions close to the electrode contacts the activation volume correctly represented focal generators. Time-courses of original and reconstructed sources were significantly correlated. The case study results showed accurate localization. sLORETA is a distributed source model, which can be applied for reliable grid and strip based source localization. For distant source positions, overestimation of the extent of the generator has to be taken into account. sLORETA-based source reconstruction has the potential to improve the localization of distributed generators in presurgical epilepsy diagnostics and cognitive neuroscience.
authors: Epilepsy Center, University Hospital Freiburg, Freiburg im Breisgau, Germany. matthias.duempelmann@uniklinik-freiburg.de
authors: Matthias
authors: M
authors: Dümpelmann
authors: Tonio
authors: T
authors: Ball
authors: Andreas
authors: A
authors: Schulze-Bonhage
references: Epilepsy Res. 2000 Sep;41(2):169-78
references: 10940618
references: Brain. 2001 Sep;124(Pt 9):1683-700
references: 11522572
references: AJNR Am J Neuroradiol. 2005 May;26(5):1078-83
references: 15891163
references: Brain Topogr. 2004 Summer;16(4):277-80
references: 15379227
references: Electroencephalogr Clin Neurophysiol. 1996 Aug;99(2):183-90
references: 8761054
references: Ann N Y Acad Sci. 2009 Jul;1169:494-8
references: 19673829
references: J Clin Neurophysiol. 1999 May;16(3):225-38
references: 10426406
references: Neuroimage. 2011 Feb 1;54(3):1966-74
references: 20884360
references: Comput Intell Neurosci. 2009;:659247
references: 19557137
references: IEEE Trans Biomed Eng. 1992 Jun;39(6):541-57
references: 1601435
references: IEEE Trans Biomed Eng. 1998 Apr;45(4):440-8
references: 9556961
references: IEEE Trans Biomed Eng. 1997 Sep;44(9):867-80
references: 9282479
references: Clin Neurophysiol. 2005 Nov;116(11):2707-16
references: 16214401
references: J Clin Neurophysiol. 2003 May-Jun;20(3):163-78
references: 12881663
references: Hum Brain Mapp. 2002 May;16(1):47-62
references: 11870926
references: Neuroimage. 2009 Jul 1;46(3):708-16
references: 19264143
references: Neurosci Lett. 2009 Jun 26;457(2):66-70
references: 19429164
references: Hum Brain Mapp. 2010 Jan;31(1):140-9
references: 19639553
references: J Clin Neurophysiol. 1999 May;16(3):267-95
references: 10426408
references: Neurology. 2004 Mar 23;62(6 Suppl 3):S2-8
references: 15037671
references: Neuroimage. 2009 Jan 15;44(2):399-410
references: 18848896
references: Neuron. 2010 Feb 25;65(4):541-9
references: 20188658
references: Clin Neurophysiol. 2002 May;113(5):725-34
references: 11976052
references: Clin Neurophysiol. 2002 May;113(5):713-24
references: 11976051
references: Epilepsia. 2008 Feb;49(2):201-18
references: 17941844
references: Clin Neurophysiol. 2009 Jun;120(6):1061-9
references: 19394893
references: Neuroimage. 2008 Aug 15;42(2):683-95
references: 18579412
references: Epilepsia. 2006 Jun;47(6):981-90
references: 16822244
references: Clin Neurophysiol. 1999 Jun;110(6):1013-28
references: 10402088
references: Methods Find Exp Clin Pharmacol. 2002;24 Suppl D:5-12
references: 12575463
references: AJNR Am J Neuroradiol. 2002 Mar;23(3):400-3
references: 11901007
references: Neuroimage. 2007 Apr 1;35(2):814-26
references: 17293126
references: Brain Topogr. 2004 Summer;16(4):287-90
references: 15379229
references: Clin Neurophysiol. 2004 Oct;115(10):2195-222
references: 15351361
references: Science. 1999 Sep 3;285(5433):1582-5
references: 10477525
references: J Clin Neurophysiol. 2007 Apr;24(2):101-19
references: 17414966