title: Specialty supplements and prostate cancer risk in the VITamins and Lifestyle (VITAL) cohort.
abstract: Although there is evidence from studies of prostate cancer cell lines and rodent models that several supplements may have antiinflammatory, antioxidant, or other anticancer properties, few epidemiologic studies have examined the association between nonvitamin, nonmineral, "specialty" supplement use and prostate cancer risk. Participants, 50-76 yr, were 35,239 male members of the VITamins and Lifestyle (VITAL) cohort who were residents of western Washington state, and who completed an extensive baseline questionnaire in 2000-2002. Participants responded about their frequency (days/wk) and duration (yr) of specialty supplement uses. 1,602 incident invasive prostate cancers were obtained from the Surveillance, Epidemiology, and End Results registry. Multivariate-adjusted hazards ratios (HR) and 95% confidence intervals (95% CI) were estimated by Cox proportional hazards models. Any use of grapeseed supplements was associated with a 41% (HR 0.59, 95% CI: 0.40-0.86) reduced risk of total prostate cancer. There were no associations for use of chondroitin, coenzyme Q10, fish oil, garlic, ginkgo biloba, ginseng, glucosamine, or saw palmetto. Grapeseed may be a potential chemopreventive agent; however, as current evidence is limited, it should not yet be promoted for prevention of prostate cancer.
authors: Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA. tbrasky@fhcrc.org
authors: Theodore M
authors: TM
authors: Brasky
authors: Alan R
authors: AR
authors: Kristal
authors: Sandi L
authors: SL
authors: Navarro
authors: Johanna W
authors: JW
authors: Lampe
authors: Ulrike
authors: U
authors: Peters
authors: Ruth E
authors: RE
authors: Patterson
authors: Emily
authors: E
authors: White
references: Cancer Causes Control. 1999 Dec;10(6):597-605
references: 10616828
references: Prostate. 2009 Nov 1;69(15):1668-82
references: 19670229
references: Biol Pharm Bull. 2006 Feb;29(2):375-9
references: 16462049
references: Int J Cancer. 2007 Apr 1;120(7):1529-35
references: 17211860
references: Nutr Cancer. 2006;55(1):21-7
references: 16965237
references: Arch Pharm Res. 2004 Apr;27(4):429-35
references: 15180309
references: Mol Cancer Ther. 2008 May;7(5):1258-67
references: 18445658
references: Cytokine. 2009 Aug;47(2):137-42
references: 19560935
references: Mol Cancer Ther. 2006 May;5(5):1265-74
references: 16731759
references: Cancer Res. 2007 Jun 15;67(12):5976-82
references: 17575168
references: J Nutr. 2004 Jun;134(6):1529-35
references: 15173424
references: J Am Diet Assoc. 2004 Jan;104(1):27-34
references: 14702580
references: Clin Cancer Res. 2006 Aug 1;12(15):4662-70
references: 16899616
references: Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1419-28
references: 19423520
references: Asian Pac J Cancer Prev. 2006 Oct-Dec;7(4):599-603
references: 17250435
references: Pharmacoepidemiol Drug Saf. 2010 Jul;19(7):694-8
references: 20582906
references: PLoS One. 2009 Oct 09;4(10):e7398
references: 19816598
references: Mol Cancer Ther. 2006 Dec;5(12):3294-302
references: 17172433
references: Altern Ther Health Med. 2005 Jan-Feb;11(1):42-9
references: 15712765
references: Prostate. 2002 Sep 1;52(4):297-304
references: 12210490
references: Carcinogenesis. 2004 Jun;25(6):987-95
references: 14742313
references: Int J Oncol. 2007 Sep;31(3):593-600
references: 17671686
references: Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H515-23
references: 19098112
references: Prostate. 2008 Nov 1;68(15):1647-54
references: 18663730
references: Mol Cell Biochem. 2006 Aug;288(1-2):107-13
references: 16691315
references: Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):187-91
references: 19502020
references: Cancer Res. 2010 Apr 15;70(8):3382-90
references: 20395211
references: Altern Med Rev. 2009 Jun;14(2):172-6
references: 19594226
references: Br J Pharmacol. 2008 Jun;154(4):843-51
references: 18536737
references: Int J Cancer. 2010 Jan 1;126(1):171-9
references: 19521962
references: Biofactors. 2003;18(1-4):265-70
references: 14695942
references: Cancer Cell. 2004 Mar;5(3):263-73
references: 15050918
references: Arch Intern Med. 2005 Feb 14;165(3):281-6
references: 15710790
references: JAMA. 1998 Nov 11;280(18):1569-75
references: 9820257
references: J Agric Food Chem. 2006 Nov 15;54(23):8804-11
references: 17090126
references: Oncogene. 2003 Mar 6;22(9):1302-16
references: 12618755
references: Ann Epidemiol. 2000 Aug;10(6):361-9
references: 10964002
references: Osteoarthritis Cartilage. 2003 Apr;11(4):290-8
references: 12681956
references: Eur J Cancer Prev. 2000 Apr;9(2):125-30
references: 10830580
references: Int J Cancer. 2008 Aug 1;123(3):660-3
references: 18338754
references: Cancer Cell Int. 2009 Sep 10;9:25
references: 19744341
references: Asian Pac J Cancer Prev. 2008 Jan-Mar;9(1):7-14
references: 18439064
references: Anticancer Res. 2007 Mar-Apr;27(2):937-48
references: 17465224
references: Ann Ist Super Sanita. 2007;43(4):348-61
references: 18209268
references: Drug Metab Dispos. 2004 Dec;32(12):1377-82
references: 15333514
references: J Am Acad Dermatol. 2011 Dec;65(6):1145-51
references: 21664718
references: Br J Nutr. 2008 May;99 E Suppl 1:ES78-108
references: 18503737
references: Am J Epidemiol. 2004 Jan 1;159(1):83-93
references: 14693663
references: J Nutr. 2006 Mar;136(3 Suppl):821S-826S
references: 16484573
references: J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8
references: 20534755
references: Nutr Cancer. 2006;56(1):50-6
references: 17176217
references: Cancer Res. 2007 Sep 1;67(17):8396-405
references: 17804756
references: Cancer Causes Control. 2001 Nov;12(9):789-96
references: 11714106
references: Menopause. 2002 Mar-Apr;9(2):145-50
references: 11875334
references: Science. 1997 Jan 10;275(5297):218-20
references: 8985016
references: Phytother Res. 2009 Sep;23(9):1197-204
references: 19140172
references: Am J Epidemiol. 2003 May 15;157(10):944-54
references: 12746248
references: Prostate. 2009 Jul 1;69(10):1045-54
references: 19301309
references: Carcinogenesis. 2006 Jul;27(7):1445-53
references: 16474170