title: The role of T lymphocytes in cancer patients undergoing immunotherapy with autologous dendritic cells.
abstract: BACKGROUND
  Cancer stems from mutations in specific genes that induce uncontrolled cell proliferation. Dendritic cells (DCs) are important immunologic cells and play a crucial role in the induction of an antitumour response.
  
  
  METHODS
  We examined the immune response mediated by T lymphocytes, helper T cells, cytotoxic T cells, and regulatory T cells, as well as the cytokines [interleukin (IL)-2, IL-12, interferon (IFN)-γ, tumour necrosis factor (TNF)-α and IL-10], produced by these cell populations, in cancer patients (N = 7) undergoing immunotheraphy with autologous DCs.
  
  
  RESULTS
  We observed an initial increase in T helper cells (CD4+) expressing IL-2, IFN-γ, IL-12, TNF-α, and IL-10 after initiation of treatment, with statistically significant for the cytokines IL-2, TNF-α and IL-10. A similar significant effect was observed for IL-2-expressing cytotoxic T cells (CD8+). The percentage of total T cells (CD3+) remained elevated throughout immunotherapy. Regulatory T cells (CD25+/FOXP3+) only showed high percentage of their maximum value when analyzed the pretreatment levels, with statistically significant.
  
  
  CONCLUSIONS
  Immunotherapy with DCs stimulated the immune response, as evidenced by an increase in percent fluorescence of most cell populations investigated during the specified treatment period.
authors: Research Institute for Oncology-IPON, Federal University of the Triângulo Mineiro-UFTM, Uberaba, Minas Gerais, Brazil.
authors: Cláudia M
authors: CM
authors: Rodrigues
authors: Bruna F
authors: BF
authors: Matias
authors: Eddie F C
authors: EF
authors: Murta
authors: Márcia A
authors: MA
authors: Michelin
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