title: A novel water-soluble heptaplatin analogue with improved antitumor activity and reduced toxicity.
abstract: A novel water-soluble heptaplatin analogue, cis-[(4R,5R)-4,5-bis-(aminomethyl)-2-isopropyl-1,3-dioxolane](3-hydroxy-1,1-cyclobutanedicarboxylato)platinum(II), has been synthesized and biologically evaluated. The complex shows more activity and less toxicity than its parent drug heptaplatin, exhibiting the great potential for further development.
authors: State Key Lab of Advanced Technologies for PGMs, Kunming Institute of Precious Metals, Kunming 650106, PR China.
authors: Weiping
authors: W
authors: Liu
authors: Xizhu
authors: X
authors: Chen
authors: Qingsong
authors: Q
authors: Ye
authors: Yongping
authors: Y
authors: Xu
authors: Chengying
authors: C
authors: Xie
authors: Mingjin
authors: M
authors: Xie
authors: Qiaowen
authors: Q
authors: Chang
authors: Liguang
authors: L
authors: Lou