title: Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs.
abstract: Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.
authors: Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea.
authors: Eun-Joo
authors: EJ
authors: Shin
authors: Jae-Hyung
authors: JH
authors: Bach
authors: Sung Youl
authors: SY
authors: Lee
authors: Jeong Min
authors: JM
authors: Kim
authors: Jinhwa
authors: J
authors: Lee
authors: Jau-Shyong
authors: JS
authors: Hong
authors: Toshitaka
authors: T
authors: Nabeshima
authors: Hyoung-Chun
authors: HC
authors: Kim