title: Differences and similarities of postprandial lipemia in rodents and humans.
abstract: BACKGROUND
  The rat has been a mainstay of physiological and metabolic research, and more recently mice. This study aimed at characterizing the postprandial triglyceride profile of two members of the Muridae family: the Wistar rats (Rattus norvegicus albinus) and C57BL/6 mice (Mus musculus) plus comparing them to the profile obtained in humans.
  
  
  METHODS
  Thirty-one male and twelve female Wistar rats, ten C57BL/6 male and nine female mice received a liquid meal containing fat (17%), protein (4%) and carbohydrates (4%), providing 2 g fat/Kg. Thirty-one men and twenty-nine women received a standardized liquid meal containing fat (25%), dextromaltose (55%), protein (14%), and vitamins and minerals (6%), and providing 40 g of fat per square meter of body surface. Serial blood samples were collected at 2, 4, 6, 8 and 10 h after the ingestion in rats, at 1, 2, 3, 4, 5 and 6 h in mice and in humans at 2, 4, 6 and 8 h. Wilcoxon and Mann-Whitney tests were used.
  
  
  CONCLUSIONS
  The triglyceride responses were evaluated after the oral fat loads. Fasting and postprandial triglyceridemia were determined sequentially in blood sample. AUC, AUIC, AR, RR and late peaks were determined.
  
  
  CONCLUSIONS
  Rats are prone to respond in a pro-atherogenic manner. The responses in mice were closer to the ones in healthy men. This study presents striking differences in postprandial triglycerides patterns between rats and mice not correlated to baseline triglycerides, the animal baseline body weight or fat load in all animal groups.
authors: Department of Clinical Pathology, Lipid Laboratory and Center for Medicine and Experimental Surgery, Faculty of Medical Sciences, Rua Tessália Vieira de Camargo, University of Campinas, Campinas 13084-971, Brazil.
authors: Natalia B
authors: NB
authors: Panzoldo
authors: Aline
authors: A
authors: Urban
authors: Eliane S
authors: ES
authors: Parra
authors: Rogério
authors: R
authors: Oliveira
authors: Vanessa S
authors: VS
authors: Zago
authors: Lívia R
authors: LR
authors: da Silva
authors: Eliana C
authors: EC
authors: de Faria
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