title: Effect of CPAP on oxidative stress and circulating progenitor cell levels in sleep patients with apnea-hypopnea syndrome.
abstract: BACKGROUND
  The sleep apnea-hypopnea syndrome is associated with elevated oxidative stress, which is associated with reduced levels and functional impairment of progenitor cells.
  
  
  OBJECTIVE
  To evaluate whether one month of CPAP treatment affects circulating-progenitor-cell levels and  oxidative stress in patients with sleep apnea-hypopnea syndrome.
  
  
  METHODS
  We enrolled 13 patients with sleep apnea-hypopnea syndrome who required nasal CPAP. We evaluated white-blood-cell oxidative stress and CD45-, CD34+, KDR+, and CD133+ cell levels via flow-cytometry, before and one  month after CPAP treatment.
  
  
  RESULTS
  Superoxide anion and hydrogen peroxide were reduced, and markers of protection against oxidative stress were increased after CPAP. Progenitor-cell levels increased significantly after CPAP. There was a significant negative correlation between CD45-,  CD34+, KDR+, and CD133+ cell levels and the severity of sleep apnea-hypopnea syndrome and superoxide anion.
  
  
  CONCLUSIONS
  CD45-, CD34+, KDR+, and CD133+ cell levels rose significantly and reached values close to those in the control group after one month of CPAP. This change was accompanied  by a significant decrease in oxidative stress, and no change in anthropometric or metabolic variables, including insulin resistance, weight, blood pressure, or lipid levels; consequently, the increase in progenitor-cell levels might be attributable to reduced oxidative stress.
authors: Servicio de Hematología, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain. moramurri@gmail.com
authors: Mora
authors: M
authors: Murri
authors: Regina
authors: R
authors: García-Delgado
authors: José
authors: J
authors: Alcázar-Ramírez
authors: Ana
authors: A
authors: Fernández-Ramos
authors: Juan
authors: J
authors: Alcaide
authors: Fernando
authors: F
authors: Cardona
authors: Francisco J
authors: FJ
authors: Tinahones