title: Breast fat grafting with platelet-rich plasma: a comparative clinical study and current state of the art.
abstract: BACKGROUND
  The role of platelet-rich plasma in enhancing fat graft take is attracting the scientific community. There is, however, a lack of clinical studies on the matter. The aim of this article is to report the authors' experience in breast fat grafting with and without platelet-rich plasma and to investigate the state of the art on adipose tissue platelet-rich plasma enrichment.
  
  
  METHODS
  The authors retrospectively reviewed 42 women who underwent breast fat grafting between September of 2007 and September of 2009. Seventeen of these patients (40 percent) were grafted with fat (according to Coleman) enriched with platelet-rich plasma at 10 percent (group A), and 25 patients (60 percent) received only fat grafts according to Coleman (group B). All patients underwent preoperative breast ultrasound and mammography and were regularly followed up with breast ultrasound 3 months later and then at 6-month intervals. The reconstructive and aesthetic outcomes were evaluated using the following parameters: (1) clinical outcomes according to the surgeons and the patient, (2) the rate of liponecrosis at breast ultrasound, and (3) the need of further fat grafting to achieve the planned result.
  
  
  RESULTS
  The clinical outcomes, the rate of liponecrosis at breast ultrasound, and the need for further fat grafting reveal that fat grafting plus platelet-rich plasma at 10 percent is not superior to Coleman fat grafting alone.
  
  
  CONCLUSIONS
  In the authors' retrospective analysis, no effect of platelet-rich plasma was seen in enhancing fat graft take when compared with the Coleman fat graft. Further research and prospective clinical studies are needed to understand the role of platelet-rich plasma, if any, in fat grafting.
authors: Rome, Italy From the Department of Plastic and Reconstructive Surgery, Catholic University of Sacro Cuore, University Hospital Agostino Gemelli; and Department of Oculoplastics, San Carlo di Nancy Hospital.
authors: Marzia
authors: M
authors: Salgarello
authors: Giuseppe
authors: G
authors: Visconti
authors: Antonio
authors: A
authors: Rusciani
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