title: [Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis].
abstract: OBJECTIVE
  To detect the expression of stem cell transcription factor Oct-4 in squamous cell carcinoma (SCC) and seborrheic keratosis (SK) and its association with cancer stem cells.
  
  
  METHODS
  Immunohistochemistry was used to detect Oct-4 expression in 35 SCC cases, 21 SK cases and 15 normal control skin tissues.
  
  
  RESULTS
  Oct-4 expression was negative in normal skin and showed a significant difference between SCC and SK tissues (P<0.05).
  
  
  CONCLUSIONS
  The Oct-4-positive cells in SCC and SK are probably tumor stem cells. Oct-4 expression may provide an important evidence for isolation and identification of human SCC and SK stem cells.
authors: Department of Dermatology, Hainan Province Nongken Sanya Hospital, Sanya, China. syliyuyang@sohu.com
authors: Yu-yang
authors: YY
authors: Li
authors: Yong-jiang
authors: YJ
authors: Dai
authors: Bin
authors: B
authors: Deng
authors: Xiong-an
authors: XA
authors: Liang
authors: Zhi-jie
authors: ZJ
authors: Xie
authors: Hai-fu
authors: HF
authors: Chen