title: Cell cycle reactivation in mature neurons: a link with brain plasticity, neuronal injury and neurodegenerative diseases?
abstract: Although the cell cycle machinery is essentially linked to cellular proliferation, recent findings suggest that neuronal cell death is frequently concurrent with the aberrant expression of cell cycle proteins in post-mitotic neurons. The present work reviews the evidence of cell cycle reentry and expression of cell cycle-associated proteins as a complex response of neurons to insults in the adult brain but also as a mechanism underlying brain plasticity. The basic aspects of cell cycle mechanisms, as well as the evidence showing cell cycle protein expression in the injured brain, are reviewed. The discussion includes recent experimental work attempting to establish a correlation between altered brain plasticity and neuronal death, and an analysis of recent evidence on how neural cell cycle dysregulation is related to neurodegenerative diseases especially the Alzheimer's disease. Understanding the mechanisms that control reexpression of proteins required for cell cycle progression which is involved in brain remodeling, may shed new light into the mechanisms involved in neuronal demise under diverse pathological circumstances. This would provide valuable clues about the possible therapeutic targets, leading to potential treatment of presently challenging neurodegenerative diseases.
authors: Department of Genomic Medicine and Toxicology, Institute of Biomedical Research, National University of Mexico, Mexico City, Mexico.
authors: Karina
authors: K
authors: Hernández-Ortega
authors: Ricardo
authors: R
authors: Quiroz-Baez
authors: Clorinda
authors: C
authors: Arias
references: Cell. 2007 Oct 19;131(2):378-90
references: 17956737
references: Exp Cell Res. 1995 Aug;219(2):612-8
references: 7641812
references: Nat Cell Biol. 2001 Jun;3(6):552-8
references: 11389439
references: Neuropathol Appl Neurobiol. 2000 Aug;26(4):390-7
references: 10931373
references: Aging (Albany NY). 2009 Apr 28;1(4):363-71
references: 20157524
references: Neuron. 2009 May 14;62(3):312-26
references: 19447088
references: J Cell Biol. 1998 Oct 19;143(2):457-67
references: 9786955
references: Nature. 1996 Feb 22;379(6567):736-9
references: 8602221
references: Biochim Biophys Acta. 2007 Apr;1772(4):467-72
references: 17095196
references: Am J Pathol. 2009 Mar;174(3):891-7
references: 19164506
references: Nat Cell Biol. 2002 Nov;4(11):859-64
references: 12389032
references: Cereb Cortex. 2007 Aug;17(8):1821-9
references: 17050646
references: J Neurosci. 1997 Feb 15;17(4):1256-70
references: 9006970
references: J Neurosci Res. 2007 Jun;85(8):1744-51
references: 17455309
references: Neurochem Res. 2007 Oct;32(10):1799-807
references: 17404835
references: Acta Neuropathol. 1997 Mar;93(3):294-300
references: 9083562
references: Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3585-90
references: 17360686
references: J Neurosci. 2003 Mar 15;23(6):2131-40
references: 12657672
references: Mol Neurodegener. 2009 Mar 16;4:14
references: 19291319
references: Learn Mem. 2010 Dec 22;18(1):49-57
references: 21191042
references: Biochim Biophys Acta. 2007 Apr;1772(4):402-8
references: 17182224
references: J Biol Chem. 2005 Sep 2;280(35):31208-19
references: 15975926
references: Int J Dev Neurosci. 2004 Nov;22(7):507-14
references: 15465280
references: Nature. 1992 Sep 24;359(6393):288-94
references: 1406932
references: Biochim Biophys Acta. 2007 Apr;1772(4):409-12
references: 17196375
references: Mol Biol Cell. 1995 Feb;6(2):185-97
references: 7787245
references: Nature. 1992 Sep 24;359(6393):295-300
references: 1406933
references: Neuron. 2003 Mar 6;37(5):735-49
references: 12628165
references: Curr Opin Cell Biol. 1995 Dec;7(6):773-80
references: 8608007
references: Eur J Neurosci. 2004 Jun;19(11):2953-66
references: 15182302
references: Tanpakushitsu Kakusan Koso. 2006 Aug;51(10 Suppl):1362-9
references: 16922401
references: Exp Neurol. 2003 Jan;179(1):17-27
references: 12504864
references: Acta Neurobiol Exp (Wars). 2004;64(1):107-12
references: 15190685
references: Acta Neuropathol. 1997 Jul;94(1):6-15
references: 9224524
references: J Neurosci. 2010 Mar 17;30(11):3973-82
references: 20237268
references: J Neurochem. 2008 Oct;107(1):127-40
references: 18665912
references: Prog Neurobiol. 2004 Jan;72(1):1-25
references: 15019174
references: Oncogene. 1995 Jul 20;11(2):211-9
references: 7624138
references: Curr Biol. 2004 Sep 21;14(18):R787-96
references: 15380093
references: Eur J Neurosci. 2009 Mar;29(6):1096-107
references: 19302146
references: Exp Neurol. 1998 Apr;150(2):240-7
references: 9527893
references: J Biol Chem. 1999 Jul 2;274(27):19011-6
references: 10383401
references: Neuroreport. 2002 Mar 25;13(4):413-6
references: 11930151
references: J Neurosci. 2007 Aug 22;27(34):9201-19
references: 17715356
references: Biochim Biophys Acta. 2007 Apr;1772(4):413-21
references: 17236750
references: J Neurosci. 1996 Feb 1;16(3):1150-62
references: 8558244
references: Curr Opin Pharmacol. 2003 Aug;3(4):362-70
references: 12901944
references: Aging Cell. 2010 Feb;9(1):64-77
references: 19895631
references: Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13650-5
references: 14595022
references: Nature. 1992 Sep 24;359(6393):328-30
references: 1406937
references: J Neurosci. 1987 Mar;7(3):829-36
references: 3559714
references: J Biol Chem. 2010 Apr 30;285(18):14052-61
references: 20189989
references: Acc Chem Res. 2003 Jun;36(6):417-25
references: 12809528
references: J Neurosci Res. 2000 Jul 15;61(2):128-33
references: 10878584
references: Aging (Albany NY). 2009 Apr;1(4):382-8
references: 19946466
references: Am J Pathol. 2003 Mar;162(3):823-35
references: 12598317
references: Neuropathol Appl Neurobiol. 2008 Aug;34(4):457-65
references: 17995921
references: Cell Tissue Res. 2001 Aug;305(2):217-28
references: 11545259
references: Neuron. 2008 May 22;58(4):571-83
references: 18498738
references: J Alzheimers Dis. 2009;16(3):541-9
references: 19276549
references: Acta Neurobiol Exp (Wars). 2009;69(2):232-53
references: 19593337
references: J Neurosci. 2001 Apr 15;21(8):2661-8
references: 11306619
references: Neuroreport. 1996 Nov 25;7(18):3047-9
references: 9116237
references: J Neurosci. 2010 Apr 14;30(15):5219-28
references: 20392944
references: Mol Cell. 2002 May;9(5):1005-16
references: 12049737
references: Neuron. 1994 Feb;12(2):343-55
references: 8110463
references: J Neurosci. 1998 Apr 15;18(8):2801-7
references: 9525997
references: Cell Death Differ. 2010 Jul;17(7):1189-98
references: 20111042
references: Biochim Biophys Acta. 2007 Apr;1772(4):392-401
references: 17229557
references: EMBO J. 1994 Mar 1;13(5):1114-22
references: 8131745
references: Science. 2008 Mar 21;319(5870):1665-8
references: 18356527
references: Development. 1995 Aug;121(8):2385-95
references: 7671804
references: Nature. 1998 Sep 10;395(6698):124-5
references: 9744267
references: J Neuropathol Exp Neurol. 2003 Jan;62(1):68-74
references: 12528819
references: Mutagenesis. 2008 Jan;23(1):57-65
references: 18048581
references: Science. 2004 Feb 13;303(5660):1026-30
references: 14716021
references: J Neurosci. 2003 Mar 1;23(5):1649-58
references: 12629169
references: Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14080-5
references: 16166266
references: J Biol Chem. 2002 Apr 5;277(14):11617-20
references: 11805123
references: FASEB J. 1999 Dec;13(15):2225-34
references: 10593870
references: Int J Dev Neurosci. 2008 Nov;26(7):665-71
references: 18768156
references: J Neurosci. 1997 May 15;17(10):3588-98
references: 9133382
references: Trends Neurosci. 2005 Jul;28(7):348-52
references: 15913799
references: Cell Cycle. 2002 May-Jun;1(3):220-6
references: 12429936
references: Acta Neuropathol. 2009 Jul;118(1):167-79
references: 19390859
references: Nature. 2007 Aug 16;448(7155):811-5
references: 17700700
references: Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10254-9
references: 10944192
references: Acta Neuropathol. 2002 Oct;104(4):369-76
references: 12200623