title: Etoposide pharmacokinetics in a jaundiced infant with letterer-siwe variant of langerhans cell histiocytosis.
abstract: An infant with hepatocellular jaundice due to Langerhans cell histiocytosis was treated and responded well to intravenous etoposide. Pharmacokinetics demonstrated similar clearance and AUC data in both the jaundiced and non-jaundiced states but myelosuppression was greater when the infant was jaundiced. Children with hepatocellular jaundice require dose reductions of etoposide, despite the similar drag pharmacokinetics to the non-jaundiced state. The mechanisms involved are discussed.
authors: HOSP SICK CHILDREN,DEPT HAEMATOL & ONCOL,LONDON WC1,ENGLAND. ST BARTHOLOMEWS HOSP,DEPT MED ONCOL,BARRY REED ONCOL LAB,LONDON EC1,ENGLAND.
authors: P
authors: P
authors: Plowman
authors: S
authors: S
authors: Joel
authors: S
authors: S
authors: Herman