title: Utility and limitations of Addenbrooke's Cognitive Examination-Revised for detecting mild cognitive impairment in Parkinson's disease.
abstract: OBJECTIVE
  To evaluate the utility of the Addenbrooke's Cognitive Examination-Revised (ACE-R) as a screening tool for mild cognitive impairment in Parkinson's disease (PD-MCI).
  
  
  METHODS
  PD patients underwent comprehensive neuropsychological and neurological evaluations and ACE-R assessment.
  
  
  RESULTS
  The ACE-R was superior to the Mini-Mental State Exam (MMSE) in detecting PD-MCI, with a cutoff score of ≤93 offering a sensitivity of 61% and a specificity of 64%. The utility of the ACE-R in detecting PD-MCI is largely influenced by the fluency sub-domain score, and has optimal discriminability when utilized in patients with lower levels of education (≤12 years of formal schooling).
  
  
  CONCLUSIONS
  The ACE-R must be used cautiously as a screening tool for PD-MCI, with results being most influenced by its fluency sub-domain score and patient education levels.
authors: University of New South Wales and Neuroscience Research Australia, Sydney, N.S.W.
authors: Natalie C
authors: NC
authors: Komadina
authors: Zoe
authors: Z
authors: Terpening
authors: Yue
authors: Y
authors: Huang
authors: Glenda M
authors: GM
authors: Halliday
authors: Sharon L
authors: SL
authors: Naismith
authors: Simon J G
authors: SJ
authors: Lewis