title: Abronione, a rotenoid from the desert annual Abronia villosa.
abstract: A high-throughput phytochemical investigation of Abronia villosa afforded a new rotenoid designated abronione (1) along with the known compounds boeravinone C and lupeol. The structure of 1 was determined using NMR, MS, and optical analysis with < 400 µg of material. Compound 1 displayed moderate cytotoxicity against NCI-H460 and HL-60 human cancer cell lines with IC(50) values of 14 and 36 µM, respectively.
authors: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States.
authors: Courtney M
authors: CM
authors: Starks
authors: Russell B
authors: RB
authors: Williams
authors: Vanessa L
authors: VL
authors: Norman
authors: Julie A
authors: JA
authors: Lawrence
authors: Matt G
authors: MG
authors: Goering
authors: Mark
authors: M
authors: O'Neil-Johnson
authors: Jin-Feng
authors: JF
authors: Hu
authors: Stephanie M
authors: SM
authors: Rice
authors: Gary R
authors: GR
authors: Eldridge
references: J Natl Cancer Inst. 2007 Jun 20;99(12):949-61
references: 17565155
references: Phytochem Anal. 2005 Mar-Apr;16(2):127-33
references: 15881121
references: J Agric Food Chem. 1999 May;47(5):2130-6
references: 10552508
references: Cancer Prev Res (Phila). 2008 Dec;1(7):577-87
references: 19139008
references: Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3380-4
references: 9520374
references: J Med Chem. 2007 Apr 19;50(8):1933-8
references: 17341062
references: Anal Chem. 2002 Aug 15;74(16):3963-71
references: 12199561