title: Human cancers express mutator phenotypes: origin, consequences and targeting.
abstract: Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.
authors: Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA. laloeb@u.washington.edu
authors: Lawrence A
authors: LA
authors: Loeb
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