title: [A multiplicity of morbidity and prognostic factors in patients with septic and acute kidney injury].
abstract: OBJECTIVE
  To investigate the risk factors of morbidity and prognosis in patients with acute kidney injury (AKI) due to sepsis.
  
  
  METHODS
  A case-control retrospective study was carried out in AKI patients with/without sepsis from February 2000.to March 2010. APACHE III and ATN-ISI were calculated. Multivariate logistic regression analysis was used to explore the clinical data and the risk factors of morbidity and prognosis in patients with septic AKI.
  
  
  RESULTS
  (1) The overall mortality rate was 23.3% and the mortality rate of septic AKI patients 44.6%. (2) With no correlation with the level of D-dimer (r = 0.356, P = 0.019), the number of failed organs was positively correlated with the mortality rate in septic AKI patients (r = 0.545, P < 0.01). (3) As demonstrated by multivariate analysis, D-dimer (> 2.2 mg/L), supports of vasoactive agents, APTT (activated partial thromboplastin time) (> 50 s) were the pathogenetic risk factors for septic AKI patients; APACHE III score (> 60), the number of failed organs, supports of mechanical ventilation were the prognostic risk factors for septic AKI patients.
  
  
  CONCLUSIONS
  The pathogenetic risk factors of septic AKI patients are D-dimer (> 2.2 mg/L), supports of vasoactive agents and APTT (> 50 s); APACHE III score (> 60), the number of failed organs and supports of mechanical ventilation are the prognostic risk factors for septic AKI patients. D-dimer may predict the morbidity of septic AKI patients, but it can not predict their prognoses.
authors: Department of Nephrology, First Affiliated Hospital, Wenzhou Medical Collage, Wenzhou 325000, China.
authors: Juan
authors: J
authors: Liu
authors: Zhen
authors: Z
authors: Su
authors: Zhou-cang
authors: ZC
authors: Zhang