title: Preparation and quality control of ¹⁷⁷Lu-[tris(1,10-phenanthroline) lutetium(III)] complex for therapy.
abstract: The ¹⁷⁷Lu-[tris(1,10-phenanthroline)lutetium(III)] complex (¹⁷⁷Lu-PQ3) was prepared successfully with high radiochemical purity (> 99%). Lu-177 chloride was obtained by thermal neutron flux (4 × 10¹³ n.cm⁻².s⁻¹) of natural Lu₂(NO₃)₃ sample, dissolved in acidic media. The radiochemical yield was checked by measuring the radiochemical purity of the (177)Lu-PQ complex by ITLC (10 mM DTPA, pH = 5, as mobile phase). The final complex solution was injected intravenously into wild-type male rats and bio-distribution of the complex was checked for up to 48 hours. The dose limiting organs were shown to be the reticulu-endothelial system. The bio-distribution of the labelled compounds in tumour-bearing animals is under investigation.
authors: Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran.
authors: Hassan
authors: H
authors: Yousefnia
authors: Amir R
authors: AR
authors: Jalilian
authors: S
authors: S
authors: Zolghadri
authors: A
authors: A
authors: Bahrami-Samani
authors: S
authors: S
authors: Shirvani-Arani
authors: M
authors: M
authors: Ghannadi-Maragheh