title: Notch destabilises maternal beta-catenin and restricts dorsal-anterior development in Xenopus.
abstract: The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and also contains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain.
authors: Laboratorio de Embriología Molecular, Instituto de Biología Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, piso 3, 1121 Ciudad Autónoma de Buenos Aires, Argentina.
authors: Helena
authors: H
authors: Acosta
authors: Silvia L
authors: SL
authors: López
authors: Diego R
authors: DR
authors: Revinski
authors: Andrés E
authors: AE
authors: Carrasco