title: Lack of prognostic significance for p53-overexpression and Ki-67-immunoreactivity in oral T1-2 squamous cell carcinomas.
abstract: Previous investigations on squamous cell carcinomas (SCC) of the head and neck region have failed to reveal a significant correlation between p53-overexpression or Ki-67-immunoreactivity and survival. Contrary to these studies we restricted the evaluation to T1-2 SCC from the oral cavity. Immunohistochemically identified p53-overexpression was observed in 69% of the tumours, and Ki-67-positive cancer cells ranged from 12 to 83% in individual rumours (median 37%). No significant correlation was found between p53-overexpression or Ki-67-positivity and survival. Although the degree of tumour differentiation and the pattern of invasion correlated with prognosis (p=0.0387 and 0.0319 respectively), these associations were too weak to be used as prognostic markers.
authors: UNIV OSLO,RIKSHOSP,NATL HOSP,DEPT OTOLARYNGOL,N-0027 OSLO,NORWAY. UNIV OSLO,INST PATHOL,N-0027 OSLO,NORWAY. MARIE SKLODOWSKA CURIE MEM INST,INST ONCOL,GLIWICE,POLAND.
authors: D
authors: D
authors: Lange
authors: A
authors: A
authors: Heyden
authors: E
authors: E
authors: Lie
authors: P
authors: P
authors: Brandtzaeg
authors: M
authors: M
authors: Boysen
authors: O
authors: O
authors: Clausen