title: Circulating levels of a biomarker of collagen metabolism are associated with health-related quality of life in patients with chronic heart failure.
abstract: OBJECTIVE
  Assessment of circulating levels of collagen-derived peptides has been proposed as a useful tool to monitor indirectly myocardial collagen metabolism in chronic heart failure (CHF) patients. The potential link between circulating concentrations of collagen metabolism biomarkers and health-related quality of life (HRQOL) has not been adequately evaluated. With the present study, we investigated the association between serum levels of collagen-derived peptides and HRQOL.
  
  
  METHODS
  We studied 280 consecutive outpatients (of mean age 67 ± 10 years, 180 men) with CHF. Serum concentrations of carboxy-terminal telopeptide of collagen type I (CITP)-a marker of collagen type I degradation-were measured in all patients both at baseline and during a period of 6 months follow-up. HRQOL was assessed by Minnesota living with heart failure questionnaire (MLHFQ).
  
  
  RESULTS
  CITP levels were significantly associated with MLHFQ scores both at baseline (r = 0.231, P < 0.001) and at 6 months follow-up (r = 0.145, P = 0.044). CITP levels remained significantly associated with MLHFQ score in multivariable linear regression analysis. Higher CITP levels were observed with higher MLHFQ scores (poor HRQOL) both at baseline (P = 0.001) and at 6 months (P = 0.041). Unadjusted analysis demonstrated a significant relationship between increasing CITP levels during 6 months follow-up and worsening HRQOL (r = 0.204, P = 0.001). The aforementioned correlation remained significant in multivariable linear regression analysis.
  
  
  CONCLUSIONS
  Our findings show that increased CITP levels are associated with poorer HRQOL in patients with CHF. These findings are consistent with a link between a pathophysiologic mechanism, i.e., collagen metabolism and patient self-assessed health status in CHF.
authors: University Cardiology Department, Medical School, Democritus University of Thrace, Voulgaroktonou 23, 68100 Alexandroupolis, Greece.
authors: Sofia V
authors: SV
authors: Chatzikyriakou
authors: Dimitrios N
authors: DN
authors: Tziakas
authors: Georgios K
authors: GK
authors: Chalikias
authors: Dimitrios
authors: D
authors: Stakos
authors: Dimitrios
authors: D
authors: Papazoglou
authors: Asimina
authors: A
authors: Lantzouraki
authors: Adina
authors: A
authors: Thomaidi
authors: Harisios
authors: H
authors: Boudoulas
authors: Stavros
authors: S
authors: Konstantinides
references: Circulation. 2010 Apr 13;121(14):1645-54
references: 20385961
references: Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:6242-6
references: 19965089
references: Eur J Heart Fail. 2008 Dec;10(12):1181-5
references: 18849192
references: Cardiovasc Res. 2002 Jul;55(1):76-82
references: 12062710
references: J Am Coll Cardiol. 2002 May 1;39(9):1414-21
references: 11985901
references: Circulation. 2009 May 12;119(18):2471-9
references: 19398668
references: J Card Fail. 2006 Aug;12(6):439-45
references: 16911910
references: Clin Chem. 1993 Apr;39(4):635-40
references: 8472358
references: Qual Life Res. 2004 Feb;13(1):63-72
references: 15058788
references: Am Heart J. 2005 Oct;150(4):707-15
references: 16209970
references: Arch Intern Med. 2005 Jun 13;165(11):1274-9
references: 15956007
references: Curr Heart Fail Rep. 2007 Sep;4(3):170-7
references: 17883994
references: J Card Fail. 2001 Jun;7(2):194-201
references: 11420772
references: Eur J Heart Fail. 2001 Oct;3(5):517-26
references: 11595599
references: Annu Rev Cell Dev Biol. 2001;17:463-516
references: 11687497
references: Hypertension. 2002 Aug;40(2):136-41
references: 12154103
references: Am J Hypertens. 2010 May;23(5):488-94
references: 20134406
references: Circ J. 2007 Jun;71(6):929-35
references: 17526992
references: Eur Heart J. 1995 Jul;16 Suppl F:4-6
references: 8521884
references: J Card Fail. 2009 Nov;15(9):763-9
references: 19879462
references: Am J Cardiol. 1993 May 1;71(12):1106-7
references: 8475878
references: Eur J Cardiovasc Prev Rehabil. 2007 Oct;14(5):589-607
references: 17925617
references: Int J Cardiol. 2005 Dec 7;105(3):294-9
references: 16274771
references: Am Heart J. 2009 Oct;158(4 Suppl):S64-71
references: 19782791
references: Am J Cardiol. 2009 Oct 1;104(7):904-9
references: 19766754
references: Pharmacoeconomics. 1999 Jan;15(1):19-46
references: 10345157
references: Eur J Prev Cardiol. 2012 Feb;19(1):62-71
references: 20479644
references: Circulation. 2000 Nov 28;102(22):2700-6
references: 11094035
references: J Mol Cell Cardiol. 1994 Mar;26(3):279-92
references: 8028011
references: Brain Behav Immun. 2010 Feb;24(2):229-35
references: 19800964
references: Circulation. 1997 Oct 21;96(8):2488-92
references: 9355880
references: Eur Heart J. 2008 Oct;29(19):2388-442
references: 18799522
references: J Adv Nurs. 2010 Oct;66(10):2287-96
references: 20735508
references: Circulation. 2003 Sep 16;108(11):1395-403
references: 12975244
references: Circulation. 1997 Mar 18;95(6):1686-744
references: 9118558
references: J Heart Lung Transplant. 2001 Sep;20(9):1016-24
references: 11557198
references: Am Heart J. 1992 Oct;124(4):1017-25
references: 1529875
references: J Card Fail. 1995 Jun;1(3):201-6
references: 9420652
references: J Card Fail. 2009 Dec;15(10):835-42
references: 19944359
references: JAMA. 2009 Jan 28;301(4):383-92
references: 19176440
references: Am J Cardiol. 1995 May 1;75(14):913-8
references: 7733000