title: Photoreceptor degeneration changes magnetic resonance imaging features in a mouse model of retinitis pigmentosa.
abstract: Retinal degeneration-1 (rd1) mice are animal models of retinitis pigmentosa, a blinding disease caused by photoreceptor cell degeneration. This study aims to determine magnetic resonance imaging (MRI) changes in retinas of 1- and 3-month-old rd1 mice. Apparent diffusion coefficient in retina was measured using diffusion MRI. The blood-retinal barrier leakage was evaluated using gadolinium-diethylenetriaminepentaacetic acid-enhanced T(1)-weighted MRI before and after systemic gadolinium-diethylenetriaminepentaacetic acid injection. Photoreceptor degeneration in rd1 retina was apparent by decreased retinal thickness and loss of water diffusion anisotropy in both 1- and 3-month-old rd1 mice. Furthermore, statistically significant increase of mean retinal apparent diffusion coefficient and gadolinium-diethylenetriaminepentaacetic acid-enhanced T(1)-weighted MRI signals were observed in 3-month-old rd1 mice comparing with age-matched wild-type mice. Together, these data suggest that MRI parameter changes can signature common pathological changes in photoreceptor-degenerated eyes, particularly blood-retinal barrier leakage-induced retinal edema.
authors: Department of Mechanical Engineering & Materials Science, Washington University, St. Louis, Missouri, USA.
authors: Qing
authors: Q
authors: Wang
authors: Sheng-Kwei
authors: SK
authors: Song
authors: Huiying
authors: H
authors: Zhang
authors: Bruce A
authors: BA
authors: Berkowitz
authors: Shiming
authors: S
authors: Chen
authors: Samuel A
authors: SA
authors: Wickline
authors: Junjie
authors: J
authors: Chen
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