title: Comparison of posterior capsule opacification with hydrophobic acrylic and hydrophilic acrylic intraocular lenses.
abstract: OBJECTIVE
  To compare posterior capsule opacification (PCO) 3 years postoperatively in contralateral eyes with a single-piece hydrophobic acrylic and 1 of 2 single-piece hydrophilic acrylic intraocular lenses (IOLs) with different configurations.
  
  
  METHODS
  Iladevi Cataract and IOL Research Institute, Ahmedabad, India.
  
  
  METHODS
  Prospective randomized clinical trial.
  
  
  METHODS
  A hydrophobic Acrysof (hydrophobic group) or a hydrophilic C-flex (hydrophilic group C) or Akreos Adapt IOL (hydrophilic group A) was randomized for implantation in the fellow eye or vice versa of each patient. The Evaluation of Posterior Capsule Opacification (EPCO) area, EPCO score, and neodymium:YAG (Nd:YAG) capsulotomy rates were compared using digital photographs.
  
  
  RESULTS
  The study enrolled 68 patients. Although there was no significant difference at 1 month, the median EPCO score was statistically significantly lower in the hydrophobic group than in hydrophilic group C (P = .00) and hydrophilic group A (P = .000) at 3 years. There were no significant differences in the median EPCO area at 1 month; however, the area was statistically significantly less in the hydrophobic group than in hydrophilic group C and hydrophilic group A at 3 years (both P = .000). Four (12.9%) of 31 eyes in hydrophilic group C and 5 (16%) of 31 eyes in hydrophilic group A required an Nd:YAG capsulotomy; no eye in the hydrophobic group required a capsulotomy (P = .04 and P = .02, respectively).
  
  
  CONCLUSIONS
  Posterior capsule opacification was significantly less with the Acrysof hydrophobic acrylic IOL at 3 years.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors: Iladevi Cataract & IOL Research Centre, Raghudeep Eye Clinic, Memnagar, Ahmedabad, India.
authors: Abhay R
authors: AR
authors: Vasavada
authors: Shetal M
authors: SM
authors: Raj
authors: Alpesh
authors: A
authors: Shah
authors: Gauri
authors: G
authors: Shah
authors: Viraj
authors: V
authors: Vasavada
authors: Vaishali
authors: V
authors: Vasavada