title: Role of sex hormones in the modulation of cholangiocyte function.
abstract: Over the last years, cholangiocytes, the cells that line the biliary tree, have been considered an important object of study for their biological properties which involves bile formation, proliferation, injury repair, fibrosis and angiogenesis. Cholangiocyte proliferation occurs in all pathologic conditions of liver injury where it is associated with inflammation and regeneration. During these processes, biliary cells start to secrete different cytokines, growth factors, neuropeptides and hormones which represent potential mechanisms for cross talk with other liver cells. Several studies suggest that hormones, and in particular, sex hormones, play a fundamental role in the modulation of the growth of this compartment in the injured liver which functionally conditions the progression of liver disease. Understanding the mechanisms of action and the intracellular pathways of these compounds on cholangiocyte pathophysiology will provide new potential strategies for the management of chronic liver diseases. The purpose of this review is to summarize the recent findings on the role of sex hormones in cholangiocyte proliferation and biology.
authors: Romina Mancinelli, Antonio Franchitto, Eugenio Gaudio, Department of Human Anatomy, University of Rome "La Sapienza", Rome 00161, Italy.
authors: Romina
authors: R
authors: Mancinelli
authors: Paolo
authors: P
authors: Onori
authors: Sharon
authors: S
authors: Demorrow
authors: Heather
authors: H
authors: Francis
authors: Shannon
authors: S
authors: Glaser
authors: Antonio
authors: A
authors: Franchitto
authors: Guido
authors: G
authors: Carpino
authors: Gianfranco
authors: G
authors: Alpini
authors: Eugenio
authors: E
authors: Gaudio
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