title: Incidental Lewy body disease: electrophysiological findings suggesting pre-clinical Lewy body disorders.
abstract: OBJECTIVE
  Evaluate electrophysiologic findings in incidental Lewy body disease (ILBD).
  
  
  METHODS
  ILBD, Control, and Parkinson's disease (PD) subjects had electrophysiological evaluation within 2 years prior to autopsy. Data analyzed included surface electromyography (EMG) of upper extremity muscles during rest and muscle activation, and electroencephalography (EEG) recording at rest. For EMG, gross tracings and spectral peaks were analyzed. EEG measures analyzed were background frequency and power in delta, theta, alpha, and beta bands.
  
  
  RESULTS
  Three of ten ILBD subjects (30%) showed unilateral rhythmic EMG discharges at rest without a visually apparent rest tremor. The ILBD resting EMG frequency was lower than in the Control group with no overlap (P=.03) and close to that of the PD group. The ILBD group had significantly lower background rhythm frequency than the Control group (P=.001) but was greater than the PD group (P=.01).
  
  
  CONCLUSIONS
  The electrophysiologic changes in ILBD cases are between those of Control and PD, suggesting that these findings may reflect changes correlating with ILBD as a possible precursor to PD.
  
  
  CONCLUSIONS
  Electrophysiologic changes in ILBD may assist with the identification of a preclinical stage for Lewy body disorders and help the development of a therapeutic agent for modifying Lewy body disease progression.
authors: Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA. jcaviness@mayo.edu
authors: John N
authors: JN
authors: Caviness
authors: Charles H
authors: CH
authors: Adler
authors: Joseph G
authors: JG
authors: Hentz
authors: Holly A
authors: HA
authors: Shill
authors: Virgilio G H
authors: VG
authors: Evidente
authors: Erika D
authors: ED
authors: Driver-Dunckley
authors: Marwan N
authors: MN
authors: Sabbagh
authors: Lucia
authors: L
authors: Sue
authors: Thomas G
authors: TG
authors: Beach
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