title: Core-shell-corona micelle stabilized by reversible cross-linkage for intracellular drug delivery.
abstract: Reversibly cross-linked core-shell-corona micelles based on a triblock copolymer composed of poly(aliphatic ester), polyphosphoester, and poly(ethylene glycol) are reported. The triblock copolymer is synthesized through consecutive ring-opening polymerization of ε-caprolactone and 2,4-dinitrophenylthioethyl ethylene phosphate, followed by conjugation of poly(ethylene glycol). After deprotection under mild conditions, the amphiphilic polymer forms core-shell-corona micelles with free thiols in the shell. Cross-linking of the micelles within the shell reduces their critical micellization concentration and enhances their stability against severe conditions. The redox-sensitive cross-linkage allows the facilitated release of entrapped anticancer drugs in the cytoplasm in response to the intracellular reductive environment. With enhanced stability during circulation after administration, and accelerated intracellular drug release at the target site, the biocompatible and biodegradable shell-cross-linked polymeric micelle is promising as a drug vehicle for cancer chemotherapy.
authors: Department of Polymer Science and Engineering and CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
authors: Yu-Cai
authors: YC
authors: Wang
authors: Yang
authors: Y
authors: Li
authors: Tian-Meng
authors: TM
authors: Sun
authors: Meng-Hua
authors: MH
authors: Xiong
authors: Juan
authors: J
authors: Wu
authors: Yi-Yan
authors: YY
authors: Yang
authors: Jun
authors: J
authors: Wang