title: The rs2910164:G>C SNP in the MIR146A gene is not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
abstract: The rs2910164:G>C SNP is located in the gene for miR-146a, a microRNA that binds the 3' UTR of the BRCA1 transcript. Preliminary data based on the analysis of a small number of cases suggested that this single nucleotide polymorphism (SNP) might be associated with the age of onset of familial breast and ovarian cancer. This effect was not confirmed on a large series of familial breast cancer cases negative for a BRCA1 or BRCA2 mutation. We show here a lack of association of the rs2910164:G>C SNP with breast cancer risk in a series of 1,166 BRCA1 and 560 BRCA2 mutation carriers. In conclusion, the polymorphism in the miR-146a gene is unlikely to be of substantial significance regarding breast cancer risk.
authors: CNRS UMR5286 Inserm U1052, Equipe Labellisée LIGUE 2008, Université Lyon 1, Cancer Research Centre of Lyon, Centre Léon Bérard, Lyon, France.
authors: Amandine I
authors: AI
authors: Garcia
authors: David G
authors: DG
authors: Cox
authors: Laure
authors: L
authors: Barjhoux
authors: Carole
authors: C
authors: Verny-Pierre
authors: Daniel
authors: D
authors: Barnes
authors: Antonis C
authors: AC
authors: Antoniou
authors: Dominique
authors: D
authors: Stoppa-Lyonnet
authors: Olga M
authors: OM
authors: Sinilnikova
authors: Sylvie
authors: S
authors: Mazoyer