title: Retinol-binding protein 4 is associated with prediabetes in adults from the general population: the Cooperative Health Research in the Region of Augsburg (KORA) F4 Study.
abstract: OBJECTIVE
  We examined the association between retinol-binding protein 4 (RBP4), a novel adipokine, and prediabetes (isolated impaired fasting glucose [i-IFG], isolated impaired glucose tolerance [i-IGT], and combined IFG and IGT) in men and women aged 32-81 years.
  
  
  METHODS
  The analysis was based on 2,614 participants without previously diagnosed diabetes and those with newly diagnosed diabetes of the Cooperative Health Research in the Region of Augsburg (KORA) F4 Study, conducted from 2006 to 2008 in southern Germany. Plasma RBP4 was analyzed by immunonephelometry.
  
  
  RESULTS
  In logistic regression analysis, RBP4 levels in the fourth quartile versus the first quartile were significantly associated with prediabetes (i-IGT, i-IFG, and IFG/IGT; reference normal glucose tolerance) independent of known metabolic risk factors and lifestyle variables (odds ratio 1.63 [95% CI 1.17-2.27] after multivariable adjustment). Stratification by sex showed generally similar results.
  
  
  CONCLUSIONS
  RBP4 levels were associated with prediabetes in individuals from the general population. Prospective studies investigating the impact of RBP4 on the development of glucose intolerance are needed.
authors: Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany. christa.meisinger@helmholtz-muenchen.de
authors: Christa
authors: C
authors: Meisinger
authors: Ina M
authors: IM
authors: Rückert
authors: Wolfgang
authors: W
authors: Rathmann
authors: Angela
authors: A
authors: Döring
authors: Barbara
authors: B
authors: Thorand
authors: Cornelia
authors: C
authors: Huth
authors: Bernd
authors: B
authors: Kowall
authors: Wolfgang
authors: W
authors: Koenig
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