title: Improving Donor Livers by Inhibiting TNF-α Production.
abstract: Hepatic ischemia/reperfusion (I/R) injury has a significant influence on the outcome of liver transplants. Inhibiting certain enzymatic reactions that occur during I/R injury may have a protective effect on the liver during transplantation. After reviewing the biochemical pathways involved in hepatic I/R injury, we describe a pharmacologic line of defense against this injury by means of the enzyme tissue inhibitor of metalloproteinase 3 (TIMP-3). Current results suggest that TIMP-3 will play a clinically relevant role in improving outcomes of liver transplants by reducing I/R injury to the donor liver.
authors: Transplantation Research Laboratory, Ochsner Clinic Foundation, New Orleans, LA.
authors: Christopher P
authors: CP
authors: Zetzmann
authors: O Rama
authors: OR
authors: Swamy
authors: George E
authors: GE
authors: Loss
authors: Humberto
authors: H
authors: Bohorquez
authors: Ari J
authors: AJ
authors: Cohen
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