title: The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-β-D-glucose-treated MDA-MB-231 breast cancer cells: molecular target on cancer metabolism.
abstract: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a polyphenolic compound isolated from Rhus chinensis Mill. PGG has been known to have anti-tumor, anti-angiogenic and anti-diabetic activities. The present study revealed another underlying molecular target of PGG in MDA-MB-231 breast cancer cells by using Illumina Human Ref-8 expression BeadChip assay. Through the Beadstudio v3 micro assay program to compare the identified genes expressed in PGG-treated MDA-MB-231 cells with untreated control, we found several unique genes that are closely associated with pyruvate metabolism, glycolysis/gluconeogenesis and tyrosine metabolism, including PC, ACSS2, ACACA, ACYP2, ALDH3B1, FBP1, PRMT2 and COMT. Consistent with microarray data, real-time RT-PCR confirmed the significant down-regulation of these genes at mRNA level in PGG-treated MDA-MB-231 cells. Our findings suggest the potential of PGG as anticancer agent for breast cancer cells by targeting cancer metabolism genes.
authors: Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyung Hee University, Seoul 130-701, Korea.
authors: Woo Sik
authors: WS
authors: Yu
authors: Soo-Jin
authors: SJ
authors: Jeong
authors: Ji-Hyun
authors: JH
authors: Kim
authors: Hyo-Jung
authors: HJ
authors: Lee
authors: Hyo Sook
authors: HS
authors: Song
authors: Min-Seok
authors: MS
authors: Kim
authors: Eunjung
authors: E
authors: Ko
authors: Hyo-Jeong
authors: HJ
authors: Lee
authors: Jae-Ho
authors: JH
authors: Khil
authors: Hyeung-Jin
authors: HJ
authors: Jang
authors: Young Chul
authors: YC
authors: Kim
authors: Hyunsu
authors: H
authors: Bae
authors: Chang Yan
authors: CY
authors: Chen
authors: Sung-Hoon
authors: SH
authors: Kim
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