title: Prevalence of psychotic symptoms in a community-based Parkinson disease sample.
abstract: OBJECTIVE
  : To determine the prevalence of psychotic phenomena, including minor symptoms, in a Parkinson disease (PD) sample and compare the clinical correlates associated with the various psychotic phenomena. To evaluate the extent to which cases met National Institute of Neurological Diseases and Stroke (NINDS)/National Institute of Mental Health (NIMH)-proposed criteria for PD-associated psychosis.
  
  
  METHODS
  : A total of 250 patients with idiopathic PD and Mini Mental State Exam scores greater than 23 from three community-based movement disorder clinics underwent comprehensive research diagnostic evaluations by a geriatric psychiatrist as part of a study on mood disorders in PD. Psychotic symptoms were categorized using a checklist, which included a breakdown of hallucinations, delusions, and minor symptoms. Clinical characteristics of groups with minor and other psychotic symptoms were compared. The NINDS/NIMH criteria for PD-psychosis were retrospectively applied.
  
  
  RESULTS
  : Of the total sample, 26% of patients were found to have any current psychotic symptoms, with 47.7% of those having isolated minor symptoms, and 52.3% having hallucinations and/or delusions. Compared to those with no current psychiatric symptoms, minor symptoms were associated with more depressive symptoms and worse quality of life, and 90.8% of those with psychotic symptoms fulfilled the NINDS/NIMH proposed criteria.
  
  
  CONCLUSIONS
  : Psychotic symptoms are common in PD patients, with minor psychotic phenomena present in nearly half of affected patients in a community-based sample. Psychotic symptoms, including minor phenomena, were clinically significant. The NINDS/NIMH PD-psychosis criteria captured the clinical characteristics of psychosis as it relates to PD. Longitudinal studies are needed to determine whether minor psychotic symptoms represent a precursor to hallucinations and delusions, and to further validate diagnostic criteria.
authors: Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Joel
authors: J
authors: Mack
authors: Peter
authors: P
authors: Rabins
authors: Karen
authors: K
authors: Anderson
authors: Susanne
authors: S
authors: Goldstein
authors: Stephen
authors: S
authors: Grill
authors: Elaina S
authors: ES
authors: Hirsch
authors: Susan
authors: S
authors: Lehmann
authors: John T
authors: JT
authors: Little
authors: Russell L
authors: RL
authors: Margolis
authors: Justin
authors: J
authors: Palanci
authors: Gregory
authors: G
authors: Pontone
authors: Howard
authors: H
authors: Weiss
authors: James R
authors: JR
authors: Williams
authors: Laura
authors: L
authors: Marsh
references: J Psychiatr Res. 1975 Nov;12(3):189-98
references: 1202204
references: Neurology. 1967 May;17(5):427-42
references: 6067254
references: J Neurol. 2002 Apr;249(4):419-23
references: 11967646
references: Arch Neurol. 1999 May;56(5):595-601
references: 10328255
references: Arch Gen Psychiatry. 1982 Aug;39(8):879-83
references: 7103676
references: Neurology. 1997 May;48(5 Suppl 6):S10-6
references: 9153155
references: J Neurol Sci. 2010 Feb 15;289(1-2):12-7
references: 19740486
references: Neurology. 1995 Apr;45(4):669-71
references: 7723953
references: J Neurol Neurosurg Psychiatry. 1971 Oct;34(5):502-7
references: 5127432
references: JAMA. 1971 Dec 27;218(13):1915-20
references: 5000569
references: Int J Geriatr Psychiatry. 1998 May;13(5):298-309
references: 9658262
references: J Neurol Neurosurg Psychiatry. 1998 Apr;64(4):533-5
references: 9576549
references: N Engl J Med. 1997 Oct 9;337(15):1036-42
references: 9321531
references: J Neurol Neurosurg Psychiatry. 1997 Oct;63(4):434-40
references: 9343119
references: Neurology. 2005 May 24;64(10):1712-5
references: 15911796
references: Parkinsonism Relat Disord. 2006 Oct;12(7):427-31
references: 16797214
references: Mov Disord. 2008 Mar 15;23(4):484-500
references: 18175343
references: Mov Disord. 2010 Apr 30;25(6):763-6
references: 20437542
references: Neurology. 2006 Jan 10;66(1):93-8
references: 16401853
references: Arch Neurol. 2006 May;63(5):713-6
references: 16682540
references: J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
references: 14399272
references: J Am Geriatr Soc. 2000 Aug;48(8):938-42
references: 10968298
references: J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4
references: 1564476
references: J Neurol Neurosurg Psychiatry. 2001 Jun;70(6):734-8
references: 11385005
references: Mov Disord. 2005 Nov;20(11):1439-48
references: 16028215
references: Arch Neurol. 1996 Dec;53(12):1265-8
references: 8970453
references: BMC Neurol. 2008 Jun 20;8:21
references: 18570642
references: Brain. 2000 Apr;123 ( Pt 4):733-45
references: 10734005
references: J Neurol Neurosurg Psychiatry. 2009 Aug;80(8):928-30
references: 19608786
references: Mov Disord. 2007 Jun 15;22(8):1061-8
references: 17266092
references: J Neural Transm (Vienna). 2000;107(1):59-71
references: 10809404
references: J Neurol Neurosurg Psychiatry. 2008 Jun;79(6):652-5
references: 17872984
references: J Neural Transm (Vienna). 2004 Oct;111(10-11):1447-53
references: 15480845
references: Am J Geriatr Psychiatry. 2005 Oct;13(10):844-51
references: 16223962
references: Neurology. 2001 Dec 11;57(11):2078-82
references: 11739829
references: Neurology. 2004 Jul 27;63(2):293-300
references: 15277623