title: Bidirectional interactions between bone metabolism and hematopoiesis.
abstract: Interactions between hematopoiesis and bone metabolism have been described in various developmental and pathological situations. Here we review this evidence from the literature with a focus on microenvironmental regulation of hematopoiesis and bone metabolism. Our hypothesis is that this process occurs by bidirectional signaling between hematopoietic and mesenchymal cells through cell adhesion molecules, membrane-bound growth factors, and secreted matrix proteins. Examples of steady-state hematopoiesis and pathologies are presented and support our view that hematopoietic and mesenchymal cell functions are modulated by specific microenvironments in the bone marrow.
authors: Centre de Recherche de l'Hôpital Sainte-Justine, Département de Pharmacologie, Université de Montréal, Canada.
authors: Geneviève
authors: G
authors: Despars
authors: Yves
authors: Y
authors: St-Pierre