title: There is no age limit for methadone: a retrospective cohort study.
abstract: BACKGROUND
  Data from the US indicates that methadone-maintained populations are aging, with an increase of patients aged 50 or older. Data from European methadone populations is sparse. This retrospective cohort study sought to evaluate the age trends and related developments in the methadone population of Basel-City, Switzerland.
  
  
  METHODS
  The study included methadone patients between April 1, 1995 and March 31, 2003. Anonymized data was taken from the methadone register of Basel-City. For analysis of age distributions, patient samples were split into four age categories from '20-29 years' to '50 years and over'. Cross-sectional comparisons were performed using patient samples of 1996 and 2003.
  
  
  RESULTS
  Analysis showed a significant increase in older patients between 1996 and 2003 (p < 0.001). During that period, the percentage of patients aged 50 and over rose almost tenfold, while the proportion of patients aged under 30 dropped significantly from 52.8% to 12.3%. The average methadone dose (p < 0.001) and the 1-year retention rate (p < 0.001) also increased significantly.
  
  
  CONCLUSIONS
  Findings point to clear trends in aging of methadone patients in Basel-City which are comparable, although less pronounced, to developments among US methadone populations. Many unanswered questions on medical, psychosocial and health economic consequences remain as the needs of older patients have not yet been evaluated extensively. However, older methadone patients, just as any other patients, should be accorded treatment appropriate to their medical condition and needs. Particular attention should be paid to adequate solutions for persons in need of care.
authors: Division of Substance Use Disorders, Psychiatric Hospital of the University of Basel, Wilhelm Klein-Strasse 27, 4012 Basel, Switzerland. Kenneth.Duersteler@upkbs.ch
authors: Kenneth M
authors: KM
authors: Dürsteler-MacFarland
authors: Marc
authors: M
authors: Vogel
authors: Gerhard A
authors: GA
authors: Wiesbeck
authors: Sylvie A
authors: SA
authors: Petitjean
references: Int J Drug Policy. 2010 Sep;21(5):429-31
references: 20172707
references: Mt Sinai J Med. 2000 Oct-Nov;67(5-6):340-6
references: 11064484
references: Can J Psychiatry. 2006 Sep;51(10):635-46
references: 17052031
references: Menopause. 2008 May-Jun;15(3):551-7
references: 18188138
references: Am J Psychiatry. 2008 Mar;165(3):303-5
references: 18316426
references: Gerontologist. 2004 Aug;44(4):543-7
references: 15331811
references: Mt Sinai J Med. 2001 Jan;68(1):62-74
references: 11135508
references: Eur Addict Res. 2003 Oct;9(4):176-81
references: 12970586
references: Am J Psychiatry. 2005 Aug;162(8):1494-502
references: 16055770
references: Immun Ageing. 2007 Sep 24;4:6
references: 17892544
references: Arch Gen Psychiatry. 2001 May;58(5):503-8
references: 11343531
references: J Pharmacol Toxicol Methods. 1999 Oct;42(2):61-6
references: 10924887
references: Soz Praventivmed. 2004;49(4):276-80
references: 15357530
references: Eur J Clin Pharmacol. 2007 Sep;63(9):821-7
references: 17598095
references: J Subst Abuse Treat. 2005 Apr;28(3):265-72
references: 15857727
references: J Subst Abuse Treat. 2011 Mar;40(2):132-41
references: 21036509
references: J Am Med Dir Assoc. 2003 Mar-Apr;4(2):98-100
references: 12807582
references: Drug Alcohol Depend. 2006 May 20;82(3):211-7
references: 16219428
references: Acta Psychiatr Scand. 1988 Jan;77(1):22-6
references: 3348092
references: Am J Geriatr Psychiatry. 2011 Aug;19(8):704-11
references: 21785290
references: Lancet. 2006 Jun 3;367(9525):1830-4
references: 16753485
references: Addiction. 2003 Jun;98(6):761-70
references: 12780364
references: Am J Public Health. 2000 Jul;90(7):1100-11
references: 10897189
references: JAMA. 1965 Aug 23;193:646-50
references: 14321530
references: J Psychiatr Pract. 2009 May;15(3):227-34
references: 19461397
references: Health Serv Res. 2008 Dec;43(6):2143-63
references: 18522665
references: JAMA. 1999 Oct 13;282(14):1314-6
references: 10527162
references: Aust Fam Physician. 2006 Nov;35(11):839; author reply 839
references: 17120337
references: Drug Alcohol Depend. 2006 Jul 27;83(3):218-24
references: 16384657
references: Addiction. 1998 Apr;93(4):515-32
references: 9684390
references: J Subst Abuse Treat. 2002 Sep;23(2):93-105
references: 12220607
references: JAMA. 1993 Apr 21;269(15):1953-9
references: 8385230
references: Drug Alcohol Depend. 2006 Dec 1;85(3):258-62
references: 16860495
references: Act Nerv Super (Praha). 1978 Oct;20(3):231-5
references: 751425
references: Ann Epidemiol. 2009 Mar;19(3):187-93
references: 19217001
references: Addiction. 2007 May;102(5):761-70
references: 17506153
references: Soc Work Health Care. 2007;45(4):43-62
references: 17954448
references: Am J Geriatr Psychiatry. 2008 Jun;16(6):488-97
references: 18515693
references: Lancet. 1999 Jan 16;353(9148):221-6
references: 9923893
references: Addiction. 2009 Aug;104(8):1363-72
references: 19549053
references: JAMA. 1998 Dec 9;280(22):1936-43
references: 9851480
references: Drug Alcohol Depend. 1999 Dec 1;57(2):113-25
references: 10617096
references: Psychopharmacology (Berl). 2002 May;161(2):202-12
references: 11981600
references: Drug Alcohol Depend. 2006 Feb 28;81(3):231-9
references: 16135401
references: Drug Alcohol Depend. 1998 Oct 1;52(2):167-71
references: 9800146
references: Pain Med. 2008 Apr;9(3):315-44
references: 18386306
references: J Clin Pharm Ther. 2006 Oct;31(5):477-84
references: 16958826
references: Drug Alcohol Depend. 2008 Oct 1;97(3):237-46
references: 18487025
references: Anesth Analg. 2005 Jun;100(6):1740-1745
references: 15920207
references: J Behav Med. 2004 Dec;27(6):607-22
references: 15669446
references: Addiction. 2005 Aug;100(8):1101-9
references: 16042640
references: Am J Geriatr Psychiatry. 2004 Sep-Oct;12(5):539-41
references: 15353395
references: Can J Public Health. 2004 Mar-Apr;95(2):104-9
references: 15074899
references: Subst Abuse Treat Prev Policy. 2009 Jun 12;4:14
references: 19519920
references: BMC Fam Pract. 2009 Jun 11;10:42
references: 19519882
references: Addiction. 1999 Jul;94(7):961-72
references: 10707430
references: J Stud Alcohol. 2003 Jul;64(4):520-30
references: 12921194
references: J Opioid Manag. 2009 Jan-Feb;5(1):27-37
references: 19344046