title: Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei.
abstract: Fenfluramine reduces hunger and promotes body weight loss by increasing central serotonin (5-HT) signaling. More recently, neuropeptides have been linked to the regulation of feeding behavior, metabolism and body weight. To examine possible interactions between 5-HT and neuropeptides in appetite control, fenfluramine (200 nmol/0.5 μl/side) was administered directly into the hypothalamic paraventricular nuclei (PVN) of male rats. Bilateral fenfluramine produced significant hypophagia and increased expression of PVN corticotropin releasing factor (CRF) mRNA and neuropeptide Y (NPY) mRNA in the arcuate nucleus within the first hour after drug administration. Fenfluramine's effects on feeding behavior and mRNA expression were blocked by PVN injections of a 5-HT(1-2) receptor antagonist, metergoline (15 nmol/0.5 μl/side). These data suggest that 5-HT neurons targeting hypothalamic paraventricular CRF neurons may participate in an appetite control circuit for reducing food intake.
authors: Department of Biomedical Sciences, Marquette University, Schroeder Complex 446, P.O. Box 1881, Milwaukee, WI 53201, United States.
authors: Joanne P
authors: JP
authors: Boisvert
authors: Tyler J
authors: TJ
authors: Boschuetz
authors: Jon M
authors: JM
authors: Resch
authors: Christopher R
authors: CR
authors: Mueller
authors: Sujean
authors: S
authors: Choi
references: Endocrinology. 2009 Jan;150(1):153-60
references: 18787020
references: J Comp Neurol. 1999 Jun 28;409(2):187-209
references: 10379914
references: Neuropharmacology. 2001 Aug;41(2):200-9
references: 11489456
references: Nutrition. 2000 Oct;16(10):953-60
references: 11054601
references: Histochemistry. 1987;86(6):541-9
references: 3497137
references: Brain Res. 1991 Aug 2;555(2):245-50
references: 1933336
references: Trends Pharmacol Sci. 1993 Jun;14(6):233-6
references: 8372403
references: Neuroscience. 1999 Mar;90(3):851-8
references: 10218785
references: Brain Res. 1983 Oct 31;277(2):355-60
references: 6357352
references: Pharmacol Biochem Behav. 1986 Dec;25(6):1223-30
references: 3027720
references: Am J Physiol. 1984 Jan;246(1 Pt 2):R1-12
references: 6320667
references: Neuroreport. 1994 Oct 3;5(15):1925-8
references: 7841378
references: Psychopharmacology (Berl). 1989;97(2):213-8
references: 2498930
references: Science. 2002 Jul 26;297(5581):609-11
references: 12142539
references: Brain Res. 2006 May 4;1087(1):83-6
references: 16626640
references: Nutrition. 2005 Feb;21(2):269-79
references: 15723758
references: Neurosci Lett. 2002 Aug 9;328(2):155-9
references: 12133578
references: Prog Neurobiol. 1987;28(1):1-54
references: 3547503
references: Behav Brain Res. 1996;73(1-2):37-42
references: 8788474
references: Pharmacol Biochem Behav. 1980 Feb;12(2):265-75
references: 7375488
references: J Neurosci. 2007 Jun 27;27(26):6956-64
references: 17596444
references: Neuroscience. 1981;6(4):557-618
references: 7017455
references: Behav Pharmacol. 1991 Apr;2(2):113-119
references: 11224055
references: Neuroreport. 1994 Oct 27;5(16):2113-6
references: 7865757
references: Nature. 2000 Apr 6;404(6778):661-71
references: 10766253
references: Brain Res. 2003 Dec 12;993(1-2):30-41
references: 14642828
references: N Engl J Med. 1997 Aug 28;337(9):581-8
references: 9271479
references: Neuropharmacology. 2000;39(1):123-32
references: 10665825
references: Brain Res. 2002 Feb 22;928(1-2):30-9
references: 11844469
references: Br J Pharmacol. 1996 Mar;117(6):1021-34
references: 8882592
references: Physiol Behav. 1989 Mar;45(3):565-70
references: 2787915
references: Psychopharmacology (Berl). 2005 Mar;178(2-3):241-9
references: 15719229
references: Eur J Pharmacol. 1995 Feb 14;274(1-3):221-4
references: 7768274
references: Brain Res Bull. 1990 Dec;25(6):849-59
references: 2289171