title: Lactate Effectively Covers Energy Demands during Neuronal Network Activity in Neonatal Hippocampal Slices.
abstract: Although numerous experimental data indicate that lactate is efficiently used for energy by the mature brain, the direct measurements of energy metabolism parameters during neuronal network activity in early postnatal development have not been performed. Therefore, the role of lactate in the energy metabolism of neurons at this age remains unclear. In this study, we monitored field potentials and contents of oxygen and NAD(P)H in correlation with oxidative metabolism during intense network activity in the CA1 hippocampal region of neonatal brain slices. We show that in the presence of glucose, lactate is effectively utilized as an energy substrate, causing an augmentation of oxidative metabolism. Moreover, in the absence of glucose lactate is fully capable of maintaining synaptic function. Therefore, during network activity in neonatal slices, lactate can be an efficient energy substrate capable of sustaining and enhancing aerobic energy metabolism.
authors: Faculté de Médecine Timone, Institut National de la Santé et de la Recherche Médicale U751, Université de la Méditerranée Marseille, France.
authors: Anton
authors: A
authors: Ivanov
authors: Marat
authors: M
authors: Mukhtarov
authors: Piotr
authors: P
authors: Bregestovski
authors: Yuri
authors: Y
authors: Zilberter
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