title: [The prevention cerebrospinal fluid leakage during operating anterior skull base meningioma involving paranasal sinuses].
abstract: OBJECTIVE
  To introduce a kind of method for skull base reconstruction after resecting anterior skull base tumors involving paranasal sinuses.
  
  
  METHODS
  A retrospective analysis was carried out on 13 patients who underwent anterior skull base reconstruction. Pericranial flap were detached with integrity from the frontal bone during craniotomy, after the tumor had been resected partitionedly, the cribriform plate of ethmoid bone which was involved by tumor was resected. Using the fat tissue to fill the skull-base defects and sutured the pedicled pericranial flap with surrounding normal dura mater. Then reinforced at the junction of pericranial flap and dura mater with biogel.
  
  
  RESULTS
  The pathogenic diagnosis of all cases were meningioma. I grade resection was acquired in 12 cases and II grade in 1 case according to Simpson grading standard of meningioma resection. The postoperative complications were 3 cases aseptic meningitis, 3 cases frontal syndrome. No CSF leakage, intracranial infection, nor death occurred. An average of 3. 4-year follow-up was achieved in all the cases from 9 months to 8 years, no tumor relapse.
  
  
  CONCLUSIONS
  CSF leakage can be effectively prevented by filling the skull-base defects with the fat tissue, suturing the pedicled pericranial flap with surrounding normal dura mater, and reinforcing at the junction of pericranial flap and dura mater with biogel.
authors: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
authors: Zhiquan
authors: Z
authors: Yang
authors: Xianrui
authors: X
authors: Yuan
authors: Jun
authors: J
authors: Wu
authors: Dun
authors: D
authors: Yuan
authors: Qing
authors: Q
authors: Liu
authors: Xingjun
authors: X
authors: Jiang