title: Interferon-α induces G1 cell-cycle arrest in renal cell carcinoma cells via activation of Jak-Stat signaling.
abstract: The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused growth inhibition of RCC cell lines via arrest in the G1 phase without inducing apoptosis. The resistance of RCC to IFN-α was associated with the low expression of Stat1. This study indicated that the Jak-Stat pathway should be considered a primary target for improving the response of RCC to IFN-α treatment.
authors: Department of Urology, Friendship Hospital, Capital Medical University, Beijing, China.
authors: Donghao
authors: D
authors: Shang
authors: Peiqian
authors: P
authors: Yang
authors: Yuting
authors: Y
authors: Liu
authors: Jian
authors: J
authors: Song
authors: Fengbo
authors: F
authors: Zhang
authors: Ye
authors: Y
authors: Tian