title: The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer.
abstract: OBJECTIVE
  In this study, we compared second-line chemotherapy effects of nodal metastases with other metastases sites.
  
  
  METHODS
  The medical records of 44 women with recurrent ovarian cancer who received second-line chemotherapy were retrospectively reviewed.
  
  
  RESULTS
  Median age at the time of second-line chemotherapy was 55 years (range: 31-74). Recurrent sites were as follows: 29 patients had a solitary site (abdominal cavity: 8; lymph node: 3; pelvic cavity: 10; liver: 4; lung: 4) and 15 patients had multiple sites In total, the response rate was 30% (CR: 8, PR: 5). The response rate in sensitive cases was higher than in refractory/resistant cases (50% vs 5% p = 0.002). However, age, chemotherapy regimen, histologic type and number of diseases were not related with chemotherapy effect. In all diseases, response rate tended to be higher in lymph node disease than in the others (44% vs 27%). In both sensitive and refractory/resistant cases, response rate tended to be higher in lymph node disease.
  
  
  CONCLUSIONS
  The response rate for lymph node diseases tended to be relatively high. Further study analyzing survival will be required to conclude the chemotherapy effect.
authors: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
authors: F
authors: F
authors: Kataoka
authors: H
authors: H
authors: Tsuda
authors: H
authors: H
authors: Nomura
authors: T
authors: T
authors: Chiyoda
authors: E
authors: E
authors: Tominaga
authors: A
authors: A
authors: Suzuki
authors: N
authors: N
authors: Susumu
authors: D
authors: D
authors: Aoki