title: Rational redesign of Candida antarctica lipase B for the ring opening polymerization of D,D-lactide.
abstract: Based on molecular modelling, the enzyme Candida antarctica lipase B was redesigned as a catalyst for the ring opening polymerization of D,D-lactide. Two mutants with 90-fold increased activity as compared to the wild-type enzyme were created. In a preparative synthesis of poly(D,D-lactide) the mutants greatly improved the rate and the degree of polymerization.
authors: Royal Institute of Technology, School of Biotechnology, Department of Biochemistry, AlbaNova University Centre, 106 91 Stockholm, Sweden.
authors: Mohamad
authors: M
authors: Takwa
authors: Marianne Wittrup
authors: MW
authors: Larsen
authors: Karl
authors: K
authors: Hult
authors: Mats
authors: M
authors: Martinelle