title: TGF-β/TGF-β receptor system and its role in physiological and pathological conditions.
abstract: The TGF-β (transforming growth factor-β) system signals via protein kinase receptors and Smad mediators to regulate a plethora of biological processes, including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-β signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-β signal transduction has allowed a better understanding of the disease pathogenicity as well as the identification of several molecular targets with great potential in therapeutic interventions.
authors: Institute for Medical Research, University of Belgrade, 11129 Belgrade, Serbia.
authors: Juan F
authors: JF
authors: Santibañez
authors: Miguel
authors: M
authors: Quintanilla
authors: Carmelo
authors: C
authors: Bernabeu