title: Relationship between plasma glucose levels and malignant uterine cervical neoplasias.
abstract: BACKGROUND
  There is a direct correlation between glycemic load and the risk of developing many malignant neoplasms.
  
  
  OBJECTIVE
  The aim of this study was to determine the plasma glucose levels in women with cervical cancer.
  
  
  METHODS
  The study included 177 women with anatomopathologically diagnosed uterine cervical cancer (stages 0-IV) treated between 1980 and 2008 at the Gynecology and Obstetrics outpatient service of the UFTM, Brazil. The plasma glucose levels of all patients were assayed at the time of diagnosis and correlated with tumor staging.
  
  
  RESULTS
  We statistically compared the plasma glucose levels of group 1 (cervical intraepithelial neoplasia 2-3), group 2 (stage I-II), group 3 (stage III-IV), and group 4 (control group: leiomyomas). Patient groups with poor prognosis (groups 2 and 3) showed significantly higher plasma glucose levels (P < 0.05) than those with less aggressive lesions (group 1). Plasma glucose levels were significantly higher in groups 2 and 3 than in group 4 (P < 0.05). The comparison of number of patients with plasma glucose level >90 mg/dl showed CIN versus I/II: P = 0.0753; OR = 2.018; (95% CI: 0.9236 to 4.410) and CIN versus III/IV: P = 0.0975; OR = 2.400; (95% CI: 0.8335 to 6.911).
  
  
  CONCLUSIONS
  We observed an association between high plasma glucose levels and cervical cancer cases with poor prognoses. Plasma glucose tests should be routinely used as additional prognostic parameters in patients with cervical neoplasias.
authors: Oncological Research Institute (IPON)/Discipline of Gynecology and Obstetrics.
authors: Rosekeila Simões
authors: RS
authors: Nomelini
authors: Adriano Souza Lima
authors: AS
authors: Neto
authors: Kalebe Alexandre
authors: KA
authors: Capuci
authors: Beatriz Martins Tavares
authors: BM
authors: Murta
authors: Eddie Fernando Candido
authors: EF
authors: Murta
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