title: Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions.
abstract: Novel types of PKCα activators based on isobenzofuranone bearing a myo-inositol moiety were designed and synthesized. The derivatives with bulky substituents on the myo-inositol moiety significantly activated PKCα, but their binding sites were not the same as that of phorbol ester.
authors: RIKEN Advanced Science Institute, Hirosawa, Wako, Japan.
authors: Go
authors: G
authors: Hirai
authors: Megumi
authors: M
authors: Ohkubo
authors: Yuki
authors: Y
authors: Tamura
authors: Mikiko
authors: M
authors: Sodeoka