title: Specific conformational epitope features of pathogenesis-related proteins mediating cross-reactivity between pollen and food allergens.
abstract: Selected members of plant pathogenesis-related and seed storage proteins represent specific groups of proteins with potential characteristics of allergens. Efforts to understand the mechanism by which pathogenesis-related proteins mediate a broad cross-reactivity in pollen-plant food allergens are still limited. In this study, computational biology approach was used to reveal specific structural implications and conservation of different epitopes from members of Bet v 1 and nsLTP protein families mediating cross-reactivity between pollen and food (fruits, vegetables, legumes, and nut/seeds) allergens. A commonly shared epitope conservation was found among all pollen and food Bet v 1 and nsLTP protein families, respectively. However, other allergenic epitopes were also specifically detected in each family. The implication of these conserved epitopes in a broad cross-reactivity for allergy clinical trials is here discussed.
authors: Department of Biochemistry, Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas (CSIC), Profesor Albareda 1, E-18008, Granada, Spain.
authors: Jose C
authors: JC
authors: Jimenez-Lopez
authors: Emma W
authors: EW
authors: Gachomo
authors: Oluwole A
authors: OA
authors: Ariyo
authors: Lamine
authors: L
authors: Baba-Moussa
authors: Simeon O
authors: SO
authors: Kotchoni
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