title: Tamoxifen inhibits phorbol ester-induced reactive nitrogen intermediate production by U937 cells.
abstract: Phorbol 12-myristate 13-acetate (PMA) enhanced nitrite production by U937 cells. During a 6-day treatment of U937 cells with PMA (200 nM-1000 nM) there was a significant increase (p<0.001) in NO2- secreted into the culture medium. Treatment of the same cells with tamoxifen (10(-10) M -10(-6) M) had no effect on nitrite production. However, tamoxifen was able to significantly (p<0.05) down-regulate PMA-enhanced nitrite production by U937 cells.
authors: J
authors: J
authors: Martin
authors: O
authors: O
authors: Alalami