title: Correlation between human papillomavirus infection and clinicopathological parameters in anal canal carcinoma.
abstract: We evaluated human papillomavirus (HPV) DNA in 17 anal canal tumors and its correlation with symptomatology, tumor extension and prognosis. Five squamous carcinomas and 4 cloacogenic tumors resulted HPV+. Statistical analysis showed no correlation between HPV infection and tumor morphology, lymph node involvement or prognosis, and no significant difference in the duration of symptoms between HPV+ and HPV- patients. HPV are involved in the pathogenesis of the tumors, but are not responsible for an increased neoplastic malignancy. Anoscopy with brushing or biopsy is a suitable screening method to identify HPV.
authors: UNIV ROMA LA SAPIENZA,DEPT EXPT MED & PATHOL,I-00161 ROME,ITALY.
authors: M
authors: M
authors: Indinnimeo
authors: C
authors: C
authors: Cicchini
authors: D
authors: D
authors: French
authors: M
authors: M
authors: Limiti
authors: A
authors: A
authors: Stazi
authors: E
authors: E
authors: Giarnieri
authors: A
authors: A
authors: Vecchione