title: T-cell receptor gene rearrangement in Epstein-Barr virus infectious mononucleosis.
abstract: This report describes the case of a previously healthy young man who presented with fever, pharyngitis, cervical lymphadenopathy, lymphocytosis, and severe thrombocytopenia. Serological tests for Epstein-Barr virus were diagnostic of a primary Epstein-Barr virus infectious mononucleosis but severe thrombocytopenia aroused the suspicion of a lymphoproliferative disease. T-cell receptor gene analysis performed on peripheral and bone marrow blood revealed a T-cell receptor γ-chain rearrangement without the evidence of malignancy using standard histologic and immunophenotype studies. Signs and symptoms of the infectious disease, blood count, and T-cell receptor gene rearrangement resolved with observation without the evidence of emergence of a lymphoproliferative disease. In the contest of a suspected lymphoproliferative disease, molecular results should be integrated with all available data for an appropriate diagnosis.
authors: Department of Hematology, Niguarda Ca' Granda Hospital, Piazza Ospedale Maggiore 3, 20162 Milan, Italy. laura.marbello@ospedaleniguarda.it
authors: L
authors: L
authors: Marbello
authors: M
authors: M
authors: Riva
authors: S
authors: S
authors: Veronese
authors: A M
authors: AM
authors: Nosari
authors: E
authors: E
authors: Ravano
authors: A
authors: A
authors: Colosimo
authors: L
authors: L
authors: Paris
authors: E
authors: E
authors: Morra
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