title: Kaposi's sarcoma-associated herpesvirus vFLIP and human T cell lymphotropic virus type 1 Tax oncogenic proteins activate IkappaB kinase subunit gamma by different mechanisms independent of the physiological cytokine-induced pathways.
abstract: Activation of IκB kinase subunit γ (IKKγ), a key regulator of the classical NF-κB pathway, by the vFLIP protein of Kaposi's sarcoma-associated herpesvirus (KSHV) and the Tax protein of human T cell lymphotropic virus type 1 (HTLV1) is essential for virus-associated cancer. We show that vFLIP and Tax activate this pathway by different interactions with IKKγ and independently of the ubiquitin-mediated signaling pathways induced by cytokines. Our data provide new insights into the mechanisms by which IKKγ can be activated and show that NF-κB activation by oncogenic viruses can be targeted without affecting physiologically important pathways.
authors: Infection & Immunity, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.
authors: Akira
authors: A
authors: Shimizu
authors: Mehdi
authors: M
authors: Baratchian
authors: Yasu
authors: Y
authors: Takeuchi
authors: David
authors: D
authors: Escors
authors: Douglas
authors: D
authors: Macdonald
authors: Tracey
authors: T
authors: Barrett
authors: Claire
authors: C
authors: Bagneris
authors: Mary
authors: M
authors: Collins
authors: Mahdad
authors: M
authors: Noursadeghi
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