title: Ketonethiosemicarbazones: structure-activity relationships for their melanogenesis inhibition.
abstract: A series of 2-(1-phenylalkylidene)hydrazinecarbothioamides 2, 2-(1-phenylalkyl)hydrazinecarbothioamides 3, 2-(3,4-dihydronaphthalen-1(2H)-ylidene)hydrazinecarbothioamide (4), and 2-(1-(thiophen-2-yl)ethylidene)hydrazinecarbothioamide (5) were synthesized for their melanogenesis inhibition in melanoma B16 cells. The SAR of these ketonethiosemicarbazones revealed that the benzylidene hydrogen in aldehydethiosemicarbazones 1 can be replaced by hydrophobic moiety and substitutions with alkyl group for the terminal amino hydrogen of ketonethiosemicarbazones improved the activity appreciably. In addition, the double bond in thiosemicarbazones is an important factor for the increment of hydrophobicity. Thus hydrophobic ketonethiosemicarbazones are excellent inhibitors of melanogenesis like aldehydethiosemicarbazones.
authors: College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, Republic of Korea.
authors: Pillaiyar
authors: P
authors: Thanigaimalai
authors: Ki-Cheul
authors: KC
authors: Lee
authors: Vinay K
authors: VK
authors: Sharma
authors: Eunmiri
authors: E
authors: Roh
authors: Youngsoo
authors: Y
authors: Kim
authors: Sang-Hun
authors: SH
authors: Jung