title: Treatment of cervical intraepithelial neoplasia (CIN) with interferon alpha-2a, CO2 laser (vaporization, cone) and 5-fluorouracil.
abstract: This study was undertaken to assess the effect of CO2 laser (vaporization, conization), 5-FU topical application and interferon alpha-2a parenterally in the therapy of GIN. Three hundred and forty-seven (347) women with CIN were treated with CO2 laser (vaporization, conization), 5-FU topical application and interferon alpha-2a parenterally. The cure rates in the various treatment groups were analysed by the chi(2) test. The most effective treatment used for CIN I was the combination of CO2 laser vaporization plus 5-FU (p<0.05). The most effective treatment used for CIN II was the combination of CO2 laser vaporization plus 5-FU (p<0.001). The treatment modalities used for patients with CIN III achieved the same therapeutic results (p>0.1). The addition of interferon does not achieve better cure rates in patients with CIN.
authors: UNIV CRETE,DEPT OBSTET & GYNECOL,IRAKLION,GREECE. EL VENIZELOU MATERN HOSP,DEPT OBSTET & GYNECOL 2,ATHENS,GREECE. EUROMEDICA MED INST,ATHENS,GREECE. ATHENS NAVAL HOSP,DEPT PATHOL,ATHENS,GREECE.
authors: E
authors: E
authors: Cardamakis
authors: E
authors: E
authors: Koumantakis
authors: C
authors: C
authors: Relakis
authors: I
authors: I
authors: Kotoulas
authors: A
authors: A
authors: Korantzis
authors: H
authors: H
authors: Mantouvalos
authors: C
authors: C
authors: Metalinos
authors: E
authors: E
authors: Stathopoulos
authors: V
authors: V
authors: Tzingounis