title: [Expression and prognostic value of M2 macrophages and regulatory T cells in gastric carcinoma tissue].
abstract: OBJECTIVE
  To explore the prognostic value of M2 macrophages and regulatory T cells(Tregs) in gastric carcinoma.
  
  
  METHODS
  Clinicopathological characteristics and follow up data of 135 patients with gastric carcinoma were collected. Patients included were those who underwent D2 radical resection(R0) at Zhongshan Hospital of Fudan University from February 1999 to December 2005. Tissue chips of gastric carcinoma specimen were stained using immunohistochemistry to determine the cells density and number of M2(CD163 positive) and Tregs(Foxp3 positive).
  
  
  RESULTS
  The median positive cells density of M2 macrophages and Tregs in tumor tissue were 7.48/HP and 6.33/HP, respectively, higher than that in adjacent tissues(1.37/HP and 2.92/HP, P<0.001). The density of M2 macrophages was positively correlated with that of Treg cells(r=0.415, P<0.001) in tumor tissue. The median survival of patients with low expression of M2 and Tregs(n=43) was significantly longer than those with high expression of the 2 cells(n=45) (99.0 vs. 72.3 months, P<0.05).
  
  
  CONCLUSIONS
  Combined detection of M2 macrophages and Tregs may predict the prognosis of gastric carcinoma.
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Ping
authors: P
authors: Shu
authors: Jing
authors: J
authors: Qin
authors: Xin-Yu
authors: XY
authors: Qin
authors: Yi-Hong
authors: YH
authors: Sun
authors: Zhen-Bin
authors: ZB
authors: Shen
authors: Yan-Na
authors: YN
authors: Wang
authors: Jing-Lei
authors: JL
authors: Liu