title: Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort).
abstract: OBJECTIVE
  The aim of this study was to compare the change in functional signs of venous insufficiency and venous refilling time measured by mercury strain-gauge plethysmography under the effects of the combination of Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid (Cyclo 3 Fort).
  
  
  METHODS
  An open-label clinical trial conducted in 65 women presenting with CEAP class C2s and C3s assessment criteria. At D0 and D28, functional signs were measured on a visual analog scale (VAS), venous refilling time by mercury strain-gauge plethysmography and venous reflux by echo-Doppler method.
  
  
  RESULTS
  Under treatment, venous refilling time increased from 11.7±4 s to 13.8±4.4 s with Δ of 26% (P<0.0001) and the percentage of patients showing improvement of functional symptoms ≥30% was significantly correlated (P=0.04) with the percentage of patients presenting an improvement in venous refilling time ≥10%.
  
  
  CONCLUSIONS
  Improvement in subjective functional signs under treatment with Cyclo 3 Fort was correlated with objective plethysmographic parameter improvement. There-fore, this study contributes to objectively document the benefit of prescribing this venoactive drug to active women with CEAP class C2s to C3s.
authors: Medical Evaluation, ESC CHU, Dijon, France. projet@cenbiotech.com
authors: F A
authors: FA
authors: Allaert
authors: C
authors: C
authors: Hugue
authors: M
authors: M
authors: Cazaubon
authors: J M
authors: JM
authors: Renaudin
authors: T
authors: T
authors: Clavel
authors: P
authors: P
authors: Escourrou