title: Endometrial stromal cells and immune cell populations within lymph nodes in a nonhuman primate model of endometriosis.
abstract: Mounting evidence suggests that immunological responses may be altered in endometriosis. The baboon (Papio anubis) is generally considered the best model of endometriosis pathogenesis. The objective of the current study was to investigate for the first time immunological changes within uterine and peritoneal draining lymph nodes in a nonhuman primate baboon model of endometriosis. Paraffin-embedded femoral lymph nodes were obtained from 22 normally cycling female baboons (induced endometriosis n = 11; control n = 11). Immunohistochemical staining was performed with antibodies for endometrial stromal cells, T cells, immature and mature dendritic cells, and B cells. Lymph nodes were evaluated using an automated cellular imaging system. Endometrial stromal cells were significantly increased in lymph nodes from animals with induced endometriosis, compared to control animals (P = .033). In animals with induced endometriosis, some lymph node immune cell populations including T cells, dendritic cells and B cells were increased, suggesting an efficient early response or peritoneal drainage.
authors: Department of Obstetrics, Gynaecology and Neonatology, Queen Elizabeth II Research Institute for Mothers and Infants, The University of Sydney, NSW, Australia. alison.hey-cunningham@sydney.edu.au
authors: A J
authors: AJ
authors: Hey-Cunningham
authors: A T
authors: AT
authors: Fazleabas
authors: A G
authors: AG
authors: Braundmeier
authors: R
authors: R
authors: Markham
authors: I S
authors: IS
authors: Fraser
authors: M
authors: M
authors: Berbic
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