title: RNA interference and ischemic injury.
abstract: In the early period of 21st century, RNA interference (RNAi) had emerged as one of the most important discoveries. This highly conserved endogenous gene silencing mechanism has been largely exploited as a powerful tool to determine biological functions of each gene. Both direct introduction of chemically synthesized small interference RNA (siRNA) and a plasmid or viral vectors encoding for siRNA can allow especially stable RNA knockdown. Recently, it has been widely used in the production of therapeutic drugs against hepatitis or immuno-deficiency viruses in human beings. Here, we provide a brief overview of the RNAi mechanism and the technology of RNAi on ischemic injury.
authors: Department of Cardiology, The First College of Clinical Medical Sciences & Yichang Central People's Hospital, China Three Gorges University, Yichang, 443000, Hubei, China.
authors: Min
authors: M
authors: Liu
authors: Jin
authors: J
authors: Sun
authors: Wen
authors: W
authors: Wang
authors: Jia-Wang
authors: JW
authors: Ding
authors: Shu-Guo
authors: SG
authors: Li
authors: Shubash
authors: S
authors: Adhikari
authors: Li
authors: L
authors: Li
authors: Jun
authors: J
authors: Yang
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