title: General base-guanidinium cooperation in bifunctional artificial phosphodiesterases.
abstract: Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The bifunctional catalysts presented in this work show varying extents of cooperation between catalytic units and a rate enhancement of 4 × 10(4) in the most favorable case.
authors: Dipartimento di Chimica and IMC-CNR Sezione Meccanismi di Reazione, Università La Sapienza, P.le Aldo Moro 5, 00185 Roma, Italy.
authors: Riccardo
authors: R
authors: Salvio
authors: Roberta
authors: R
authors: Cacciapaglia
authors: Luigi
authors: L
authors: Mandolini