title: Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials.
abstract: Bioinspired from adhesion behaviors of mussels, injectable and thermosensitive chitosan/Pluronic composite hydrogels were synthesized for tissue adhesives and hemostatic materials. Chitosan conjugated with multiple catechol groups in the backbone was cross-linked with terminally thiolated Pluronic F-127 triblock copolymer to produce temperature-sensitive and adhesive sol-gel transition hydrogels. A blend mixture of the catechol-conjugated chitosan and the thiolated Pluronic F-127 was a viscous solution state at room temperature but became a cross-linked gel state with instantaneous solidification at the body temperature and physiological pH. The adhesive chitosan/Pluronic injectable hydrogels with remnant catechol groups showed strong adhesiveness to soft tissues and mucous layers and also demonstrated superior hemostatic properties. These chitosan/Pluronic hydrogels are expected to be usefully exploited for injectable drug delivery depots, tissue engineering hydrogels, tissue adhesives, and antibleeding materials.
authors: Graduate School of Nanoscience and Technology (WCU), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
authors: Ji Hyun
authors: JH
authors: Ryu
authors: Yuhan
authors: Y
authors: Lee
authors: Won Ho
authors: WH
authors: Kong
authors: Taek Gyoung
authors: TG
authors: Kim
authors: Tae Gwan
authors: TG
authors: Park
authors: Haeshin
authors: H
authors: Lee