title: Metagenomic exploration of antibiotic resistance in soil.
abstract: The ongoing development of metagenomic approaches is providing the means to explore antibiotic resistance in nature and address questions that could not be answered previously with conventional culture-based strategies. The number of available environmental metagenomic sequence datasets is rapidly expanding and henceforth offer the ability to gain a more comprehensive understanding of antibiotic resistance at the global scale. Although there is now evidence that the environment constitutes a vast reservoir of antibiotic resistance gene determinants (ARGDs) and that the majority of ARGDs acquired by human pathogens may have an environmental origin, a better understanding of their diversity, prevalence and ecological significance may help predict the emergence and spreading of newly acquired resistances. Recent applications of metagenomic approaches to the study of ARGDs in natural environments such as soil should help overcome challenges concerning expanding antibiotic resistances.
authors: Environmental Microbial Genomics Group, Laboratoire AMPERE, UMR CNRS 5005, Ecole Centrale de Lyon, Université de Lyon, 36 avenue Guy de Collongue, 69134 Ecully, France.
authors: Jean-Michel
authors: JM
authors: Monier
authors: Sandrine
authors: S
authors: Demanèche
authors: Tom O
authors: TO
authors: Delmont
authors: Alban
authors: A
authors: Mathieu
authors: Timothy M
authors: TM
authors: Vogel
authors: Pascal
authors: P
authors: Simonet