title: An open, comparative, multicentre clinical study of combined oral therapy with sildenafil and doxazosin GITS for treating Chinese patients with erectile dysfunction and lower urinary tract symptoms secondary to benign prostatic hyperplasia.
abstract: This study sought to investigate the clinical efficacy and safety of combined oral therapy with sildenafil and doxazosin GITS compared to sildenafil monotherapy in treating Chinese patients with erectile dysfunction (ED) and lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH/LUTS). The trial was conducted in hospitals in Beijing, Shanghai, Changsha, Wuhan and Guangzhou, five major cities in China. A total of 250 patients diagnosed with ED and BPH/LUTS aged 50-75 years, and who had International Index of Erection Function-5 (IIEF-5) scores ≤21 and International Prostate Symptom Score (IPSS) ≥10 points, were enrolled and randomly divided into Group A (168 cases; doxazosin GITS 4 mg once daily plus sildenafil 25-100 mg on demand) and Group B (82 cases; sildenafil 25-100 mg on demand). Efficacies were evaluated by IIEF-5 and IPSS scores and a quality of life (QoL) questionnaire, and adverse effects were evaluated during the treatment period. There were no statistically significant differences in mean age, and IIEF-5, IPSS and QoL scores pre-treatment between the two groups. After treatment, IIEF-5, IPSS and QoL scores were significantly improved in Group A, while only IIEF-5 scores were significantly improved in Group B compared with pre-treatment. There were no significant differences in side effects between the two groups. The results indicated that combined therapy with sildenafil and doxazosin GITS for the treatment of ED and BPH/LUTS is safe and effective compared to sildenafil monotherapy.
authors: Andrology Center, Peking University First Hospital, Peking University, Beijing 100034, China.
authors: Zhe
authors: Z
authors: Jin
authors: Zhi-Chao
authors: ZC
authors: Zhang
authors: Ji-Hong
authors: JH
authors: Liu
authors: Jun
authors: J
authors: Lu
authors: Yu-Xin
authors: YX
authors: Tang
authors: Xiang-Zhou
authors: XZ
authors: Sun
authors: Wei-Dong
authors: WD
authors: Song
authors: Bing
authors: B
authors: Gao
authors: Ying-Lu
authors: YL
authors: Guo
authors: Zhong-Cheng
authors: ZC
authors: Xin
references: BJU Int. 2006 Apr;97(4):763-5
references: 16536769
references: J Urol. 2003 Aug;170(2 Pt 1):530-47
references: 12853821
references: Eur Urol. 2007 Jun;51(6):1717-23
references: 17258855
references: J Am Geriatr Soc. 2001 Apr;49(4):436-42
references: 11347788
references: J Urol. 1994 Jan;151(1):54-61
references: 8254833
references: Eur Urol. 2010 Apr;57(4):699-707
references: 19428174
references: Int Urol Nephrol. 2001;33(2):283-92
references: 12092641
references: Int J Impot Res. 2002 Feb;14(1):50-3
references: 11896478
references: Urology. 2008 Mar;71(3):526-30
references: 18342202
references: J Urol. 2004 Nov;172(5 Pt 1):1935-40
references: 15540759
references: Clin Interv Aging. 2006;1(4):403-14
references: 18046917
references: BJU Int. 2008 Jan;101(2):197-202
references: 18005205
references: J Sex Med. 2009 Nov;6(11):3158-65
references: 19515207
references: J Urol. 2001 Dec;166(6):2484-90
references: 11696815
references: J Sex Med. 2009 Mar;6(3):836-47
references: 19143907
references: Eur Urol. 2003 Dec;44(6):637-49
references: 14644114
references: Asian J Androl. 2008 Jan;10(1):45-53
references: 18087643
references: Urology. 2010 Jun;75(6):1452-8
references: 20163842
references: Urology. 2009 Mar;73(3):562-6
references: 19167031
references: Eur Urol. 2009 Oct;56(4):727-35
references: 19409693