title: Relationship between plasma adiponectin, retinol-binding protein 4 and uric Acid in hypertensive patients with metabolic syndrome.
abstract: OBJECTIVE
  Adipokines have been suggested for their potential use in tracking the clinical progress in the subjects with metabolic syndrome (MS). To investigate the relationship between the serum levels of adipokines {adiponectin and retinol-binding protein 4 (RBP4)} and the serum level of uric acid in hypertensive (HTN) patients with MS.
  
  
  METHODS
  In this study, 38 totally untreated HTN patients were enrolled. Anthropometric measurements, blood pressure (BP) were taken in the 12 HTN patients without MS and the 26 HTN patients with MS. Fasting blood samples were collected for measurement of adiponectin, RBP4, nitric oxide (NO), glucose, creatinine, uric acid, lipid profile and insulin.
  
  
  RESULTS
  The HTN with MS group had significant higher values of body mass index, waist length, serum uric acid and triglyceride levels than the HTN without MS group. Compared to the HTN without MS group, the HTN with MS group showed significantly lower adiponectin (p=0.030), NO (p=0.003) and high density lipoprotein levels (p<0.001). Serum adiponectin levels negatively correlated with insulin level (R=-0.453, p=0.026) and uric acid level (R=-0.413, p=0.036), and serum RBP4 levels positively correlated with uric acid level (R=0.527, p=0.006) in the HTN with MS group. Multiple linear regression analysis using RBP4 and adiponectin levels as the dependent variables showed that uric acid level correlated with serum RBP4 level (p=0.046) and adiponectin level (p=0.044).
  
  
  CONCLUSIONS
  The HTN with MS group showed a correlation with two types of adipokines (adiponectin, RBP4) and uric acid. Adiponectin, RBP4 and uric acid may be important components associated with MS, especially when associated with hypertension.
authors: Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital, Bucheon, Korea.
authors: Chan Seok
authors: CS
authors: Park
authors: Sang-Hyun
authors: SH
authors: Ihm
authors: Hun-Jun
authors: HJ
authors: Park
authors: Woo-Seung
authors: WS
authors: Shin
authors: Pum-Jun
authors: PJ
authors: Kim
authors: Kiyuk
authors: K
authors: Chang
authors: Hee-Yeol
authors: HY
authors: Kim
authors: Ho-Joong
authors: HJ
authors: Youn
authors: Wook-Sung
authors: WS
authors: Chung
authors: Ki Bae
authors: KB
authors: Seung
authors: Jae-Hyung
authors: JH
authors: Kim
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