title: Composition of fatty acids in plasma and erythrocytes and eicosanoids level in patients with metabolic syndrome.
abstract: BACKGROUND
  Disturbances of the fatty acids composition in plasma and red blood cells and eicosanoid synthesis play an important role in the metabolic syndrome (MS) formation.
  
  
  METHODS
  The observation group included 61 people with metabolic syndrome (30 patients with MS and normal levels of insulin, 31 people with MS and insulin resistance--IR). The parameters of carbohydrate and lipid metabolism in blood serum were examined. The composition of nonesterified fatty acids (NEFA), fatty acid (FA) of red blood cells lipids was analyzed by gas-liquid chromatography. Eicosanoids level in MS patients blood serum was studied by enzyme immunoassay.
  
  
  RESULTS
  In MS patients in the absence of glucose-insulin homeostasis disturbances and in patients with IR the accumulation of polyunsaturated fatty acids (18:2 n6, 18:3 n3, 22:4 n6) and lower pool of saturated FA (12:0, 14:0, 16: 0, 17:0) in plasma were discovered. A deficit of polyunsaturated FA (18:3 n3, 20:4 n6) with a predominance of on-saturated FA (14:0, 18:0) in erythrocyte membranes was revealed. In MS patients regardless of the carbohydrate metabolism status high levels of leukotriene B4 and 6-keto-prostaglandin-F1α in serum were found. The development of IR in MS patients leads to increased synthesis of thromboxane A2.
  
  
  CONCLUSIONS
  The results revealed a disturbance in nonesterified fatty acids of plasma lipids and red blood cells, eicosanoid synthesis in MS patients. The breach of the plasma and cell membranes fatty acids compositions, synthesis of vasoactive and proinflammatory eicosanoids is an important pathogenetic part of the MS development.
authors: Vladivostok Branch of the Far Eastern Center of Physiology and Pathology of Respiration of SB RAMN-Institute of Medical Climatology and Rehabilitative Treatment, Russia.
authors: Tatyana P
authors: TP
authors: Novgorodtseva
authors: Yulia K
authors: YK
authors: Karaman
authors: Natalia V
authors: NV
authors: Zhukova
authors: Elena G
authors: EG
authors: Lobanova
authors: Marina V
authors: MV
authors: Antonyuk
authors: Tatyana A
authors: TA
authors: Kantur
references: Diabetes Care. 2003 May;26(5):1362-8
references: 12716789
references: Can J Biochem Physiol. 1959 Aug;37(8):911-7
references: 13671378
references: Metabolism. 2004 Mar;53(3):310-7
references: 15015142
references: J Clin Invest. 2003 Apr;111(8):1107-13
references: 12697726
references: Am J Clin Nutr. 2005 Dec;82(6):1151-2
references: 16332644
references: J Family Community Med. 2010 May;17(2):73-8
references: 21359028
references: Biomed Pharmacother. 2002 Jul;56(5):215-22
references: 12199620
references: Circulation. 2004 Jan 27;109(3):433-8
references: 14744958
references: Am J Clin Nutr. 2005 Dec;82(6):1178-84
references: 16332649
references: Lancet. 2005 Dec 3;366(9501):1921; author reply 1923-4
references: 16325688
references: Curr Mol Med. 2011 Feb;11(1):13-25
references: 21189121
references: Am J Clin Nutr. 2006 Jun;83(6 Suppl):1505S-1519S
references: 16841861
references: Klin Lab Diagn. 2010 Oct;(10):22-5
references: 21162180
references: Curr Opin Clin Nutr Metab Care. 1998 Nov;1(6):559-63
references: 10565410
references: Klin Lab Diagn. 2008 Oct;(10):38-40
references: 19069444
references: Vopr Med Khim. 1998 Jul-Aug;44(4):317-30
references: 9845918
references: Prostaglandins Leukot Essent Fatty Acids. 1994 Nov;51(5):317-21
references: 7846102
references: Lancet. 2005 Apr 16-22;365(9468):1415-28
references: 15836891
references: N Engl J Med. 1990 Sep 6;323(10):645-55
references: 2166915
references: Klin Med (Mosk). 2009;87(5):33-7
references: 19565825