title: Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus.
abstract: A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.
authors: C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, Missouri 63108, USA. dipanjan@wustl.edu
authors: Dipanjan
authors: D
authors: Pan
authors: Shelton D
authors: SD
authors: Caruthers
authors: Angana
authors: A
authors: Senpan
authors: Ceren
authors: C
authors: Yalaz
authors: Allen J
authors: AJ
authors: Stacy
authors: Grace
authors: G
authors: Hu
authors: Jon N
authors: JN
authors: Marsh
authors: Patrick J
authors: PJ
authors: Gaffney
authors: Samuel A
authors: SA
authors: Wickline
authors: Gregory M
authors: GM
authors: Lanza
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