title: A phase-ii trial of 5-Fluorouracil, folinic Acid, vinorelbine in pretreated patients with metastic colorectal-cancer.
abstract: 43 patients with metastatic colorectal Cancer pretreated with 5-fluorouracil-based chemotherapy received vinorelbine plus 5-fluorouracil plus folinic acid with the aim of evaluating vinorelbine activity in advanced colorectal cancer and its potential synergism with commonly used drugs. 9 partial responses were observed, for an;overall objective response rate of 20.9%. 20 additional patients had stable disease (46.5%). Median duration of response was 7 months. Median survival from the start of treatment was 6 months. The main toxic effect was myelosuppression. We conclude that our regimen is active enough to warrant further evaluation in advanced colorectal cancer.
authors: UNIV CAGLIARI,IST MED INTERNA,I-09124 CAGLIARI,ITALY. IST MED LEGALE AM,MILAN,ITALY. UNIV NAPLES 2,NAPLES,ITALY. OSPED AVELLINO,DIV CHIRURG,AVELLINO,ITALY.
authors: R
authors: R
authors: Iaffaioli
authors: G
authors: G
authors: Facchini
authors: A
authors: A
authors: Tortoriello
authors: F
authors: F
authors: Caponigro
authors: G
authors: G
authors: Gesue
authors: A
authors: A
authors: Finizio
authors: N
authors: N
authors: Dimartino
authors: G
authors: G
authors: Desena
authors: B
authors: B
authors: Antonelli
authors: G
authors: G
authors: Scaramellino
authors: L
authors: L
authors: Fei
authors: M
authors: M
authors: Santangelo
authors: L
authors: L
authors: Bucci