title: Hyperglycemia and death in cystic fibrosis-related diabetes.
abstract: OBJECTIVE
  Diabetes is common in cystic fibrosis and increases the risk of death, yet the role of hyperglycemia remains unproven. An association between glycemia and mortality would provide compelling evidence to support glucose lowering in cystic fibrosis-related diabetes (CFRD).
  
  
  METHODS
  Using the U.K. Cystic Fibrosis Registry, we analyzed longitudinal data from 2006 to 2009 in 520 individuals with diabetes. We tested the association between HbA1c and mortality.
  
  
  RESULTS
  During a median follow-up of 2 years, 36 patients died. The median value of HbA1c was higher in those who died (7.3%) than in those who did not (6.7%). An HbA1c value of ≥6.5% was associated with a threefold increased risk of death (hazard ratio 3.2 [95% CI 1.4-7.3]; P=0.005) independent of potential confounders.
  
  
  CONCLUSIONS
  Hyperglycemia trebles the risk of death in patients with CFRD. These findings provide epidemiologic support for continued efforts to improve glycemic control.
authors: Wolfson Diabetes and Endocrine Clinic, Addenbrooke’s Hospital, Cambridge, UK. amanda.adler@addenbrookes.nhs.uk
authors: Amanda I
authors: AI
authors: Adler
authors: Brian
authors: B
authors: Shine
authors: Charles
authors: C
authors: Haworth
authors: Lalantha
authors: L
authors: Leelarathna
authors: Diana
authors: D
authors: Bilton
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