title: The early repolarization pattern in the general population: clinical correlates and heritability.
abstract: OBJECTIVE
  This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based cohorts.
  
  
  BACKGROUND
  There is growing recognition that ERP is associated with adverse outcomes.
  
  
  METHODS
  Participants of the Framingham Heart Study (FHS) (N = 3,995) and the Health 2000 Survey (H2K) (N = 5,489) were included. ERP was defined as a J-point elevation ≥0.1 mV in ≥2 leads in either the inferior (II, III, aVF) or lateral (I, aVL, V(4-6)) territory or both. We tested the association between clinical characteristics and ERP, and estimated sibling recurrence risk.
  
  
  RESULTS
  ERP was present in 243 of 3,955 (6.1%) of FHS and 180 of 5,489 (3.3%) of H2K subjects. Male sex, younger age, lower systolic blood pressure, higher Sokolow-Lyon index, and lower Cornell voltage were independently associated with the presence of ERP. In the FHS sample, siblings of individuals with ERP had an ERP prevalence of 11.6% (recurrence risk ratio of 1.89). Siblings of individuals with ERP had an increased unadjusted odds of ERP (odds ratio: 2.22, 95% confidence interval: 1.01 to 4.85, p = 0.047).
  
  
  CONCLUSIONS
  ERP has strong association with clinical factors and has evidence for a heritable basis in the general population. Further assessment of the genetic determinants of ERP is warranted.
authors: Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors: Peter A
authors: PA
authors: Noseworthy
authors: Jani T
authors: JT
authors: Tikkanen
authors: Kimmo
authors: K
authors: Porthan
authors: Lasse
authors: L
authors: Oikarinen
authors: Arto
authors: A
authors: Pietilä
authors: Kennet
authors: K
authors: Harald
authors: Gina M
authors: GM
authors: Peloso
authors: Faisal M
authors: FM
authors: Merchant
authors: Antti
authors: A
authors: Jula
authors: Heikki
authors: H
authors: Väänänen
authors: Shih-Jen
authors: SJ
authors: Hwang
authors: Christopher J
authors: CJ
authors: O'Donnell
authors: Veikko
authors: V
authors: Salomaa
authors: Christopher
authors: C
authors: Newton-Cheh
authors: Heikki V
authors: HV
authors: Huikuri
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