title: Hypoglycemic effect of lupin seed γ-conglutin in experimental animals and healthy human subjects.
abstract: A lupin seed γ-conglutin-enriched preparation was tested in a glucose overload trial with both murine models and adult healthy volunteers. The results with rats showed a dose-dependent significant decrease of blood glucose concentration, which confirmed previous findings obtained with the purified protein. Moreover, three test-product doses equivalent to 630, 315, and 157.5 mg γ-conglutin, orally administered 30 min before the carbohydrate supply, showed a relevant hypoglycemic effect in human trials. Insulin concentrations were not significantly affected. The general hematic parameters did not change at all. This is the first report on the glucose-lowering effect of lupin γ-conglutin in human subjects.
authors: Instituto de Medicina, Valdivia, Chile.
authors: Juan C
authors: JC
authors: Bertoglio
authors: Mario A
authors: MA
authors: Calvo
authors: Juan L
authors: JL
authors: Hancke
authors: Rafael A
authors: RA
authors: Burgos
authors: Antonella
authors: A
authors: Riva
authors: Paolo
authors: P
authors: Morazzoni
authors: Cesare
authors: C
authors: Ponzone
authors: Chiara
authors: C
authors: Magni
authors: Marcello
authors: M
authors: Duranti