title: GiSAO.db: a database for ageing research.
abstract: BACKGROUND
  Age-related gene expression patterns of Homo sapiens as well as of model organisms such as Mus musculus, Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster are a basis for understanding the genetic mechanisms of ageing. For an effective analysis and interpretation of expression profiles it is necessary to store and manage huge amounts of data in an organized way, so that these data can be accessed and processed easily.
  
  
  METHODS
  GiSAO.db (Genes involved in senescence, apoptosis and oxidative stress database) is a web-based database system for storing and retrieving ageing-related experimental data. Expression data of genes and miRNAs, annotation data like gene identifiers and GO terms, orthologs data and data of follow-up experiments are stored in the database. A user-friendly web application provides access to the stored data. KEGG pathways were incorporated and links to external databases augment the information in GiSAO.db. Search functions facilitate retrieval of data which can also be exported for further processing.
  
  
  CONCLUSIONS
  We have developed a centralized database that is very well suited for the management of data for ageing research. The database can be accessed at https://gisao.genome.tugraz.at and all the stored data can be viewed with a guest account.
authors: Division for Bioinformatics, Biocenter, Innsbruck Medical University, Schöpfstrasse, Austria.
authors: Edith
authors: E
authors: Hofer
authors: Gerhard T
authors: GT
authors: Laschober
authors: Matthias
authors: M
authors: Hackl
authors: Gerhard G
authors: GG
authors: Thallinger
authors: Günter
authors: G
authors: Lepperdinger
authors: Johannes
authors: J
authors: Grillari
authors: Pidder
authors: P
authors: Jansen-Dürr
authors: Zlatko
authors: Z
authors: Trajanoski
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