title: Synthesis of purine nucleosides built on a 3-oxabicyclo[3.2.0]heptane scaffold.
abstract: The photochemical [2 + 2] cycloaddition of chiral 3-chloro and 3-fluoro-5-hydroxymethyl-2(5H)-furanone to ethylene and acetylene has been studied. The effect of the halogen atom on the chemical yield and facial diastereoselectivity of the cycloaddition process has been evaluated. From the major anti cycloadducts, practical syntheses of several purine cyclobutane and cyclobutene-fused nucleosides containing a halogen atom have been developed. The anti-HIV activity of the new nucleoside analogues has been evaluated.
authors: Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
authors: Ramon
authors: R
authors: Flores
authors: Albert
authors: A
authors: Rustullet
authors: Ramon
authors: R
authors: Alibés
authors: Angel
authors: A
authors: Álvarez-Larena
authors: Pedro
authors: P
authors: de March
authors: Marta
authors: M
authors: Figueredo
authors: Josep
authors: J
authors: Font