title: Association of UGT1A1 Gly71Arg with urine urobilinogen.
abstract: Bilirubin is glucoronized by uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) mainly in the liver, and excreted into bile. The conjugated form is metabolized into the unconjugated form, and then into urobilinogen by bacteria in the intestine. Unconjugated bilirubin and urobilinogen are absorbed into the blood stream. The kidney filtrates conjugated bilurubin and urobilinogen into urine. Accordingly, the reduced enzyme activity of UGTIAI may decrease serum conjugated bilirubin levels, resulting in a lower frequency of positive results of urine bilirubin and urobilinogen. This study examined the associations of UGTIAI Gly71Arg (UGTIAI *6) with urine bilirubin and urobilinogen, as well as serum AST, ALT and GGT. Subjects were 5,172 inhabitants 35 to 69 years old who participated in a cohort study in Nagoya from June 2008 to May 2010. Among them, data from 5,151 participants (1,465 males and 3,686 females) were available for analysis. The age-sex-adjusted odds ratio (OR) of ArgArg relative to GlyGly was 1.37 (95% confidence interval (95% CI), 0.55-1.23) for bilirubin, and 1.67 (95% CI, 0.86-3.26) for urobilinogen. Those of ArgArg+ArgGly were 0.87 (95% CI, 0.59-1.27) and 1.50 (95% CI, 1.17-1.94), respectively. AST, ALT and GGT levels had no associations with the genotype. Although the significant association for urobilinogen was contrary to the biological expectation, this study indicated that UGTIA1 Gly71Arg may be a genetic factor of urine urobilinogen.
authors: Medical Student of Nagoya University School of Medicine, Nagoya, Japan.
authors: Ryuji
authors: R
authors: Kataoka
authors: Akiko
authors: A
authors: Kimata
authors: Kanami
authors: K
authors: Yamamoto
authors: Naoko
authors: N
authors: Hirosawa
authors: Jun
authors: J
authors: Ueyama
authors: Takaaki
authors: T
authors: Kondo
authors: Rieko
authors: R
authors: Okada
authors: Sayo
authors: S
authors: Kawai
authors: Asahi
authors: A
authors: Hishida
authors: Mariko
authors: M
authors: Naito
authors: Emi
authors: E
authors: Morita
authors: Kenji
authors: K
authors: Wakai
authors: Nobuyuki
authors: N
authors: Hamajima
references: Jpn J Cancer Res. 2000 Sep;91(9):865-8
references: 11011111
references: J Matern Fetal Neonatal Med. 2011 Feb;24(2):313-6
references: 20528217
references: Pharmacogenomics. 2008 Sep;9(9):1229-35
references: 18781851
references: Clin Chem. 2003 Dec;49(12):2078-81
references: 14633881
references: Am J Hematol. 2008 Oct;83(10):800-3
references: 18756540
references: J Hum Genet. 1999;44(1):22-5
references: 9929972
references: Int J Clin Oncol. 2009 Apr;14(2):136-42
references: 19390945
references: Cancer Res. 2000 Dec 15;60(24):6921-6
references: 11156391
references: Biochem J. 1994 Oct 1;303 ( Pt 1):233-40
references: 7945246
references: Biochim Biophys Acta. 1998 Apr 28;1406(3):267-73
references: 9630669
references: West J Emerg Med. 2009 May;10(2):85-8
references: 19561824
references: J Hum Genet. 2009 Jun;54(6):317-23
references: 19343046
references: Clin Cancer Res. 2004 Aug 1;10(15):5151-9
references: 15297419
references: Clin Lab Sci. 2008 Summer;21(3):158-61
references: 18678137
references: Pediatrics. 1999 Jun;103(6 Pt 1):1224-7
references: 10353933
references: Asian Pac J Cancer Prev. 2007 Apr-Jun;8(2):317-23
references: 17696755
references: Hum Mol Genet. 2009 Jul 15;18(14):2700-10
references: 19414484