title: Combination therapy with cisplatin, 5'-deoxy-5-fluorouridine (5'-DFUR) and mitomycin (MMC) in patients with inoperable, advanced gastric cancer.
abstract: The optimal dose of cisplatin (CDDP) for combination chemotherapy for the treatment of inoperable, advanced gastric cancer has yet to be established. We therefore performed a randomized study to compare the therapeutic usefulness of two dose levels of cisplatin. 5'-deoxy-5-fluorouridine (5'-DFUR 1,400 mg/m(2)/d) was given orally on days 1 to 4 and 15 to 18. Mitomycin C (MMC, 5.75 mg/m(2)/d) was injected intravenously on day 5. In addition, 80 mg/m2/d of CDDP (regimen A) or 60 mg/m(2)/d of CDDP (regimen B) was given by 2-h intravenous drip infusion on day 5. This treatment cycle was repeated every four weeks. Fifty-six patients were enrolled. Clinical response was evaluated in 32 patients (regimen A, 16 patients; regimen B? 16 patients) with measurable lesions. The response rate was significantly higher with regimen A (9 PR/16, 56.3%) than with regimen B (3 PR/16, 18.9%) (p=0.028, chi(2) test). Median survival was slightly but not significantly longer with regimen A (7.4 months) than with regimen B (6.3 months). Drug toxicity included myelosuppression and gastrointestinal symptoms, but there were no serious adverse reactions or differences in safety between the treatment regimens. Regimen A was associated with a high response rate and low toxicity. The optimal dose of CDDP in combination with 5'-DFUR and MMC for the treatment of advanced gastric cancer is regarded to be 80 mg/m(2).
authors: SHOWA UNIV,TOYOSU HOSP,SCH MED,TOKYO,JAPAN. SENDAI OPEN HOSP,DEPT INTERNAL MED,SENDAI,MIYAGI,JAPAN. OMUTA CITY HOSP,OMUTA,JAPAN. JUNTENDO UNIV,SCH MED,TOKYO,JAPAN. NATL OKAYAMA HOSP,DEPT INTERNAL MED,OKAYAMA,JAPAN. OMIYA RED CROSS HOSP,DEPT INTERNAL MED,OMIYA,SAITAMA,JAPAN. HIGASHI SAPPORO HOSP,AKASHI,HYOGO,JAPAN. MEITETSU HOSP,DEPT GASTROENTEROL,NAGOYA,AICHI,JAPAN.
authors: W
authors: W
authors: Koizumi
authors: M
authors: M
authors: Kurihara
authors: K
authors: K
authors: Hasegawa
authors: A
authors: A
authors: Chonan
authors: Y
authors: Y
authors: Kubo
authors: R
authors: R
authors: Maekawa
authors: R
authors: R
authors: Iwasaki
authors: T
authors: T
authors: Sasai
authors: Y
authors: Y
authors: Fukuyama
authors: K
authors: K
authors: Ishikawa
authors: K
authors: K
authors: Miyoshi
authors: K
authors: K
authors: Yasutake
authors: M
authors: M
authors: Hayakawa