title: Multivariate survival analysis of the patients with recurrent endometrial cancer.
abstract: OBJECTIVE
  Few studies on the prognosticators of the patients with recurrent endometrial cancer after relapse have been reported in the literature. The aim of this study was to determine the prognosticators after relapse in patients with recurrent endometrial cancer who underwent primary complete cytoreductive surgery and adjuvant chemotherapy.
  
  
  METHODS
  Thirty-five patients with recurrent endometrial cancer were included in this retrospective analysis. The prognostic significance of several clinicopathological factors including histologic type, risk for recurrence, time to relapse after primary surgery, number of relapse sites, site of relapse, treatment modality, and complete resection of recurrent tumors were evaluated. Survival analyses were performed by Kaplan-Meier curves and the log-rank test. Independent prognostic factors were determined by multivariate Cox regression analysis.
  
  
  RESULTS
  Among the clinicopathological factors analyzed, histologic type (p=0.04), time to relapse after primary surgery (p=0.03), and the number of relapse sites (p=0.03) were significantly related to survival after relapse. Multivariate analysis revealed that time to relapse after primary surgery (hazard ratio, 6.8; p=0.004) and the number of relapse sites (hazard ratio, 11.1; p=0.002) were independent prognostic factors for survival after relapse. Survival after relapse could be stratified into three groups by the combination of two independent prognostic factors.
  
  
  CONCLUSIONS
  We conclude that time to relapse after primary surgery, and the number of relapse sites were independent prognostic factors for survival after relapse in patients with recurrent endometrial cancer.
authors: Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors: Tetsuji
authors: T
authors: Odagiri
authors: Hidemichi
authors: H
authors: Watari
authors: Masayoshi
authors: M
authors: Hosaka
authors: Takashi
authors: T
authors: Mitamura
authors: Yousuke
authors: Y
authors: Konno
authors: Tatsuya
authors: T
authors: Kato
authors: Noriko
authors: N
authors: Kobayashi
authors: Satoko
authors: S
authors: Sudo
authors: Mahito
authors: M
authors: Takeda
authors: Masanori
authors: M
authors: Kaneuchi
authors: Noriaki
authors: N
authors: Sakuragi
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