title: Neuroprotective effects of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against oxidative stress.
abstract: Oxidative stress, glutamate excitotoxicity, and inflammation are the important pathological mechanisms in neurodegenerative diseases. Recently, we reported that 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride protects rat glial cells against glutamate-induced excitotoxicity. In this study, we report the effects of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride on primary cultured cortical astrocytes after exposure to hydrogen peroxide (H₂O₂). Pretreatment of cells with 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride prior to H₂O₂ exposure attenuated the H₂O₂-induced reductions in cell survival and superoxide dismutase, catalase, glutathione, and glutathione peroxidase activities. It also reduced H₂O₂-induced increases in reactive oxygen species levels, malondialdehyde content, and production of nitric oxide. These effects were all concentration-dependent. Our results suggest that 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride protects against oxidative stress.
authors: Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea.
authors: Hanwook
authors: H
authors: Kim
authors: Hyo Jeong
authors: HJ
authors: Son
authors: Seung Cheol
authors: SC
authors: Ha
authors: Eun-A
authors: EA
authors: Kim
authors: Tae Ue
authors: TU
authors: Kim
authors: Soo Young
authors: SY
authors: Choi
authors: Jee-Yin
authors: JY
authors: Ahn
authors: Sung-Woo
authors: SW
authors: Cho
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