title: An autonomous CMOS hysteretic sensor for the detection of desorption-free DNA hybridization.
abstract: This paper describes a sensor for label-free, fully electrical detection of DNA hybridization based on capacitive changes in the electrode-electrolyte interface. The sensor measures capacitive changes in real time according to a charging-discharging principle that is limited by the hysteresis window. In addition, a novel autonomous searching technique, which exclusively monitors desorption-free hybridized electrodes among electrode arrays, enhances the performance of the sensor compared with conventional capacitive measurement. The sensor system achieves a detection range of 80 dB. The integrated circuit sensor is fabricated with a 0.35 μm CMOS process. The proposed sensor offers rapid, robust and inexpensive measurement of capacitance with highly integrated detection circuitry. It also facilitates quantitative evaluations of molecular densities on a chip with distinctive impedance variations by monitoring desorption-free hybridized electrodes. Our electrical biosensor has great potential for use with bio analytical tools and point-of-care diagnosis.
authors: School of EECS, Korea Advanced Institute of Science and Technology, 335 Gwahakro, Yuseong-gu, Daejeon 305-701, Republic of Korea.
authors: Kang-Ho
authors: KH
authors: Lee
authors: Suk-Hwan
authors: SH
authors: Choi
authors: Jeong-Oen
authors: JO
authors: Lee
authors: Mi-Jin
authors: MJ
authors: Sohn
authors: Jun-Bo
authors: JB
authors: Yoon
authors: Gyu-Hyeong
authors: GH
authors: Cho