title: Vicenin-2, a potential anti-inflammatory constituent of Urtica circularis.
abstract: Vicenin-2 (1), a flavonoid glycoside, was isolated and identified from an ethanol extract of the aerial parts of Urtica circularis. This crude extract was found to possess significant anti-inflammatory activity in a carrageenan-induced rat hind paw edema model (41.5% inhibition at a dose of 300 mg/kg; ip). The effects of 1 on several inflammatory mediators were investigated. In cultured murine macrophages, this compound modified LPS-induced total nitrite and TNF-α production, in addition to the LPS-induced translocation of the nuclear factor NF-κB.
authors: Cátedra de Farmacognosia-IQUIMEFA CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, C1113AAD Buenos Aires, Argentina. cmarra@ffyb.uba.ar
authors: Carla
authors: C
authors: Marrassini
authors: Roberto
authors: R
authors: Davicino
authors: Cristina
authors: C
authors: Acevedo
authors: Claudia
authors: C
authors: Anesini
authors: Susana
authors: S
authors: Gorzalczany
authors: Graciela
authors: G
authors: Ferraro