title: Emerging role of bioflavonoids in gastroenterology: Especially their effects on intestinal neoplasia.
abstract: Flavonoids, secondary plant products which could be essential for normal physiology in humans and animals, may be the vitamins of the next century. Flavonoids belong to the polyphenols and possess antioxidative, anti-inflammatory, antimutagenic and anticarcinogenic properties. Among the various flavonoid species, tea flavonoids such as apigenin (from camomile) and epigallocatechin gallate (EGCG from green tea) can be used for the prevention of intestinal neoplasia, especially for adenoma and cancer prevention in the gastrointestinal tract. Numerous experimental studies with molecular and biological end points support the therapeutic efficacy of bioflavonoids. Clinical studies with cohorts and case-control trials suggest that flavonoids are effective in tertiary bioprevention but, as yet, there are no controlled randomized clinical trials. Flavonoids can inhibit inflammatory pathways and could be useful for chronic inflammatory bowel diseases. Flavonoid deficiency syndromes could be therapeutic targets in the future.
authors: Harald P Hoensch, Marien-Hospital, Private Practice of Internal Medicine, Martinspfad 72, D-64285 Darmstadt, Germany.
authors: Harald P
authors: HP
authors: Hoensch
authors: Reinhard
authors: R
authors: Oertel
references: Am J Clin Nutr. 2004 May;79(5):727-47
references: 15113710
references: Nutrition. 2009 Oct;25(10):981-97
references: 19502006
references: Mol Nutr Food Res. 2011 Jan;55(1):32-45
references: 21207511
references: Eur J Nutr. 2002 Oct;41(5):203-9
references: 12395214
references: Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3020-5
references: 18990744
references: Gut. 2007 Mar;56(3):426-35
references: 16931577
references: J Nutr. 2007 May;137(5):1244-52
references: 17449588
references: Int J Gastrointest Cancer. 2005;35(3):187-95
references: 16110120
references: Nat Rev Cancer. 2009 Jun;9(6):429-39
references: 19472429
references: Drug Dev Res. 2008 Nov 1;69(7):460-471
references: 19884979
references: World J Gastroenterol. 2008 Apr 14;14(14):2187-93
references: 18407592
references: Eur J Nutr. 1999 Jun;38(3):133-42
references: 10443335
references: Nutr Rev. 2008 Nov;66(11):630-41
references: 19019025
references: Planta Med. 2008 Oct;74(13):1608-24
references: 18855307
references: Cochrane Database Syst Rev. 2009 Jul 08;(3):CD005004
references: 19588362
references: Nutr Cancer. 2010;62(7):931-7
references: 20924968
references: Med Klin (Munich). 2010 Aug;105(8):554-9
references: 20824413