title: Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
abstract: Designed and synthesized were a series of 5H-chromeno[4,3-b]pyridines with substitution at 2- and 4-positions with various 5- or 6-membered heteroaromatics as antitumor agents. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Structure-activity relationship study showed that 2-furyl or 2-thienyl at 2- or 4-position of central pyridine is crucial in displaying topo I or II inhibitory activity and cytotoxicity.
authors: College of Pharmacy, Yeungnam University, Kyongsan 712-749, Republic of Korea.
authors: Uttam
authors: U
authors: Thapa
authors: Pritam
authors: P
authors: Thapa
authors: Radha
authors: R
authors: Karki
authors: Minho
authors: M
authors: Yun
authors: Jae Hun
authors: JH
authors: Choi
authors: Yurngdong
authors: Y
authors: Jahng
authors: Eunyoung
authors: E
authors: Lee
authors: Kyung-Hwa
authors: KH
authors: Jeon
authors: Younghwa
authors: Y
authors: Na
authors: Eun-Mi
authors: EM
authors: Ha
authors: Won-Jea
authors: WJ
authors: Cho
authors: Youngjoo
authors: Y
authors: Kwon
authors: Eung-Seok
authors: ES
authors: Lee