title: Neuroprotective effect of anthocyanin on experimental traumatic spinal cord injury.
abstract: OBJECTIVE
  We investigated the neuroprotective effect of anthocyanin, oxygen radical scavenger extracted from raspberries, after traumatic spinal cord injury (SCI) in rats.
  
  
  METHODS
  THE ANIMALS WERE DIVIDED INTO TWO GROUPS : the vehicle-treated group (control group, n=20) received an oral administration of normal saline via stomach intubation immediately after SCI, and the anthocyanin-treated group (AT group, n=20) received 400 mg/kg of cyanidin 3-O-β-glucoside (C3G) in the same way. We compared the neurological functions, superoxide expressions and lesion volumes in two groups.
  
  
  RESULTS
  At 14 days after SCI, the AT group showed significant improvement of the BBB score by 16.7±3.4%, platform hang by 40.0±9.1% and hind foot bar grab by 30.8±8.4% (p<0.05 in all outcomes). The degree of superoxide expression, represented by the ratio of red fluorescence intensity, was significantly lower in the AT group (0.98±0.38) than the control group (1.34±0.24) (p<0.05). The lesion volume in lesion periphery was 32.1±2.4 µL in the control and 24.5±2.3 µL in the AT group, respectively (p<0.05), and the motor neuron cell number of the anterior horn in lesion periphery was 8.3±5.1 cells/HPF in the control and 13.4±6.3 cells/HPF in the AT group, respectively (p<0.05).
  
  
  CONCLUSIONS
  Anthocyanin seemed to reduce lesion volume and neuronal loss by its antioxidant effect and these resulted in improved functional recovery.
authors: Department of Neurosurgery, Kyungpook National University Hospital, Daegu, Korea.
authors: Kyoung-Tae
authors: KT
authors: Kim
authors: Taek-Kyun
authors: TK
authors: Nam
authors: Yong-Sook
authors: YS
authors: Park
authors: Young-Baeg
authors: YB
authors: Kim
authors: Seung-Won
authors: SW
authors: Park
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