title: [Food intake-suppressing action of incretin and anti-obesity therapy].
abstract: Suppressing food intake is the most well-known central nervous action of glucagon-like peptide-1 (GLP-1). Neurons expressing preproglucagon (PPG) in the nucleus tractus solitarius (NTS) are the only source of "central" GLP-1, and they project to the hypothalamus. Recently, properties of these PPG-neurons have been revealed using transgenic mice expressing fluorescent protein under control of the PPG promoter; whereas they are directly responsible to leptin but not to GLP-1, they can be the second-order neurons of vagal afferents. "Peripheral" GLP-1 released from intestinal L-cells may possess central nervous action through the vagal afferent fibers. The question remains whether food intake suppression due to "peripheral" GLP-1 depends on "central" one. The action is being applied to anti-obesity therapy.
authors: Department of Diabetology and Endocrinology, Kanazawa Medical University.
authors: Atsushi
authors: A
authors: Nakagawa
authors: Makoto
authors: M
authors: Nishizawa
authors: Daisuke
authors: D
authors: Koya