title: Analysis of Amaryllidaceae alkaloids from Chlidanthus fragrans by GC-MS and their cholinesterase activity.
abstract: The underivatized alkaloid mixture extracted from the bulbs of Chlidanthus fragrans Herb. was investigated by capillary GC/MS for the first time. Fifteen known Amaryllidaceae alkaloids of five structure types were identified. The main alkaloids were tazzetine (9, tazettine-type), chlidanthine (2, galanthamine-type), belladine (8, belladine-type) and lycorine (12, lycorine-type). The alkaloid extract from the bulbs showed promising human blood acetylcholinesterase (IC50 = 20.1 +/- 2.9 microg/mL) and human plasma butyrylcholinesterase (IC50 = 136.8 +/- 6.9 microg/mL) inhibitory activity.
authors: Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. cahlikova@fafcuni.cz
authors: Lucie
authors: L
authors: Cahlíková
authors: Katerina
authors: K
authors: Macáková
authors: Stanislav
authors: S
authors: Zavadil
authors: Pavel
authors: P
authors: Jiros
authors: Lubomír
authors: L
authors: Opletal
authors: Klára
authors: K
authors: Urbanová
authors: Ludek
authors: L
authors: Jahodár