title: Impact of microRNA in normal and pathological respiratory epithelia.
abstract: Extensive sequencing efforts, combined with ad hoc bioinformatics developments, have now led to the identification of 1222 distinct miRNAs in human (derived from 1368 distinct genomic loci) and of many miRNAs in other multicellular organisms. The present chapter is aimed at describing a general experimental strategy to identify specific miRNA expression profiles and to highlight the functional networks operating between them and their mRNA targets, including several miRNAs deregulated in cystic fibrosis and during differentiation of airway epithelial cells.
authors: CNRS, Université de Nice Sophia Antipolis, IPMC, UMR6097, Sophia Antipolis, France. chami@ipmc.cnrs.fr
authors: Lisa
authors: L
authors: Giovannini-Chami
authors: Nathalie
authors: N
authors: Grandvaux
authors: Laure-Emmanuelle
authors: LE
authors: Zaragosi
authors: Karine
authors: K
authors: Robbe-Sermesant
authors: Brice
authors: B
authors: Marcet
authors: Bruno
authors: B
authors: Cardinaud
authors: Christelle
authors: C
authors: Coraux
authors: Yves
authors: Y
authors: Berthiaume
authors: Rainer
authors: R
authors: Waldmann
authors: Bernard
authors: B
authors: Mari
authors: Pascal
authors: P
authors: Barbry
references: Nat Biotechnol. 2009 Jun;27(6):549-55
references: 19465925
references: J Biol Chem. 2007 Nov 16;282(46):33632-33640
references: 17848567
references: Immunity. 2007 Dec;27(6):847-59
references: 18055230
references: Science. 2005 Jul 8;309(5732):310-1
references: 15919954
references: Nat Struct Mol Biol. 2006 Dec;13(12):1097-101
references: 17099701
references: Nat Genet. 2005 May;37(5):495-500
references: 15806104
references: Nature. 2005 Feb 17;433(7027):769-73
references: 15685193
references: RNA. 2005 Sep;11(9):1461-70
references: 16043497
references: Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19291-6
references: 18042700
references: Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9
references: 16166262
references: Science. 2007 Mar 16;315(5818):1579-82
references: 17322031
references: Nat Methods. 2004 Nov;1(2):155-61
references: 15782179
references: EMBO J. 2002 Sep 2;21(17):4663-70
references: 12198168
references: Am J Respir Cell Mol Biol. 2010 Mar;42(3):312-9
references: 19502386
references: RNA. 2006 Feb;12(2):187-91
references: 16373485
references: Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3627-32
references: 15738415
references: Cancer Res. 2005 Aug 15;65(16):7065-70
references: 16103053
references: Nat Struct Mol Biol. 2008 Apr;15(4):346-53
references: 18345015
references: Ann Thorac Surg. 2008 Feb;85(2):S737-42
references: 18222207
references: Nature. 2004 Nov 11;432(7014):231-5
references: 15531879
references: Nat Cell Biol. 2011 Jun;13(6):693-9
references: 21602795
references: RNA. 2006 May;12(5):913-20
references: 16540696
references: Nature. 2009 Jul 23;460(7254):479-86
references: 19536157
references: Ann N Y Acad Sci. 2008 Nov;1143:1-20
references: 19076341
references: Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18255-60
references: 17108080
references: Immunity. 2007 Jul;27(1):123-34
references: 17613256
references: Biotechniques. 2005 Oct;39(4):519-25
references: 16235564
references: Dev Dyn. 2006 Sep;235(9):2538-48
references: 16736490
references: Dev Dyn. 2006 Nov;235(11):3156-65
references: 17013880
references: Clin Microbiol Rev. 2001 Oct;14(4):778-809, table of contents
references: 11585785
references: Pharmacol Ther. 2009 Nov;124(2):219-34
references: 19615405
references: Science. 2007 Apr 27;316(5824):604-8
references: 17463289
references: Genes Dev. 2004 May 15;18(10):1165-78
references: 15131085
references: Nature. 2007 Jul 5;448(7149):83-6
references: 17589500
references: Biochem Biophys Res Commun. 2009 Oct 30;388(4):621-5
references: 19686699
references: Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2319-24
references: 19168627
references: J Virol. 2003 Jul;77(13):7159-65
references: 12805414
references: Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R121-32
references: 15809264
references: Biostatistics. 2003 Apr;4(2):249-64
references: 12925520
references: J Biol Chem. 2006 Jul 7;281(27):18277-84
references: 16675453
references: Mol Cell Biol. 1997 Mar;17(3):1490-502
references: 9032277
references: Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2735-40
references: 19193853
references: Science. 2007 Apr 27;316(5824):608-11
references: 17463290
references: Curr Cancer Drug Targets. 2009 Jun;9(4):572-94
references: 19519323
references: Nat Biotechnol. 2008 Apr;26(4):407-15
references: 18392026
references: N Biotechnol. 2009 Apr;25(4):195-203
references: 19429539
references: RNA. 2008 Dec;14(12):2580-96
references: 18978028
references: J Thorac Oncol. 2009 Aug;4(8):1028-34
references: 19474765
references: Nat Genet. 2006 Jun;38 Suppl:S8-13
references: 16736023
references: Science. 2005 Sep 2;309(5740):1577-81
references: 16141076
references: Cell. 2004 Jan 23;116(2 Suppl):S89-92, 1 p following S96
references: 15055592
references: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61
references: 16461460
references: RNA. 2004 Oct;10(10):1518-25
references: 15337849
references: Nat Genet. 2005 Jul;37(7):766-70
references: 15965474
references: Nat Rev Cancer. 2006 Apr;6(4):259-69
references: 16557279
references: Thorac Surg Clin. 2007 May;17(2):167-73, viii
references: 17626395
references: J Immunol. 2010 Feb 15;184(4):1702-9
references: 20083669
references: Gene. 2008 Nov 1;423(2):108-15
references: 18692553
references: Genes Dev. 2004 Mar 1;18(5):504-11
references: 15014042
references: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2208-13
references: 16452165
references: Cell. 1993 Dec 3;75(5):843-54
references: 8252621
references: Nat Methods. 2006 Jan;3(1):27-9
references: 16369549
references: RNA. 2006 Jul;12(7):1161-7
references: 16738409
references: Bioinformatics. 2007 May 15;23(10):1304-6
references: 17384016
references: Cell. 1993 Dec 3;75(5):855-62
references: 8252622
references: Cell Death Differ. 2011 Mar;18(3):465-78
references: 20885442
references: Dev Biol. 2004 Mar 15;267(2):529-35
references: 15013811
references: Mol Cell. 2007 Jun 8;26(5):611-23
references: 17560368
references: Bioinformatics. 2010 Dec 15;26(24):3131-2
references: 20959382
references: Mol Cell Biol. 2008 Nov;28(22):6773-84
references: 18794355
references: Nucleic Acids Res. 2009 Jun;37(10):3464-73
references: 19339516
references: RNA. 2010 Feb;16(2):394-404
references: 20042474
references: Nature. 2009 Oct 8;461(7265):754-61
references: 19812667
references: PLoS One. 2008 May 07;3(5):e2126
references: 18461144
references: J Biol Chem. 2008 Feb 1;283(5):2654-62
references: 18048365
references: FASEB J. 2007 Feb;21(2):415-26
references: 17167072
references: RNA. 2007 Aug;13(8):1198-204
references: 17592038
references: Nat Protoc. 2006;1(1):302-7
references: 17406249
references: Genome Biol. 2004;5(10):R80
references: 15461798
references: Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):7964-9
references: 18524951
references: FASEB J. 2009 Sep;23(9):3243-50
references: 19465468
references: BMC Genomics. 2007 Jun 15;8:172
references: 17573962
references: Nature. 2008 Sep 4;455(7209):58-63
references: 18668040
references: Immunity. 2008 May;28(5):621-9
references: 18450484
references: J Pathol. 2005 Oct;207(2):243-9
references: 16041695
references: Nature. 2005 Jun 9;435(7043):834-8
references: 15944708
references: Ann Rheum Dis. 2008 Dec;67 Suppl 3:iii50-5
references: 19022814
references: Cell. 2007 Jun 29;129(7):1401-14
references: 17604727
references: Cell. 2009 Jan 23;136(2):215-33
references: 19167326
references: Oncology. 2009;76(3):162-9
references: 19209007
references: Gene. 2001 Aug 22;274(1-2):157-67
references: 11675008
references: Nat Struct Mol Biol. 2009 Nov;16(11):1148-53
references: 19820710
references: Mol Cell. 2007 Oct 26;28(2):328-36
references: 17964270
references: Nat Rev Genet. 2008 Feb;9(2):102-14
references: 18197166
references: Nat Methods. 2009 Feb;6(2):139-41
references: 19137005
references: BMC Genomics. 2009 Nov 05;10:512
references: 19891781
references: RNA. 2007 Jan;13(1):151-9
references: 17105992
references: Cell. 2005 Jan 14;120(1):15-20
references: 15652477
references: CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96
references: 18287387
references: Nucleic Acids Res. 2004 Dec 22;32(22):e188
references: 15616155
references: Nat Methods. 2008 Dec;5(12):1023-5
references: 18978784
references: PLoS Biol. 2005 Mar;3(3):e85
references: 15723116
references: Carcinogenesis. 2010 Feb;31(2):252-8
references: 19748927
references: PLoS One. 2009 Nov 13;4(11):e7837
references: 19915717
references: Cell. 2003 Dec 26;115(7):787-98
references: 14697198
references: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9
references: 12434020
references: Am J Respir Crit Care Med. 2009 Oct 15;180(8):713-9
references: 19644046
references: RNA Biol. 2007 Jun;4(2):76-84
references: 17637574
references: PLoS One. 2009 Jun 12;4(6):e5889
references: 19521514
references: J Virol. 2008 Jun;82(11):5295-306
references: 18367535
references: Genome Biol. 2009;10(4):217
references: 19435485
references: FASEB J. 2009 Mar;23(3):806-12
references: 18952709
references: J Biol Chem. 2011 Apr 1;286(13):11604-15
references: 21282106
references: Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1604-9
references: 17242365
references: PLoS One. 2009 Aug 24;4(8):e6718
references: 19701459
references: Immunity. 2008 May;28(5):630-8
references: 18455451
references: Nat Struct Mol Biol. 2009 Dec;16(12):1259-66
references: 19946268
references: Nat Immunol. 2008 Aug;9(8):839-45
references: 18645592
references: Biochem Biophys Res Commun. 2008 Dec 12;377(2):668-673
references: 18948085
references: J Immunol. 2009 Mar 1;182(5):2578-82
references: 19234151
references: Endocr Relat Cancer. 2011 Sep 13;18(5):579-94
references: 21778212
references: Nat Rev Genet. 2009 Oct;10(10):704-14
references: 19763153
references: BMC Genomics. 2009 Nov 30;10:563
references: 19943974
references: Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4034-9
references: 16495412
references: J Immunol. 2007 Oct 15;179(8):5082-9
references: 17911593
references: Br J Haematol. 2009 Jan;144(1):138-40
references: 19016736
references: Nature. 2004 Nov 11;432(7014):235-40
references: 15531877
references: Nat Genet. 2006 Feb;38(2):228-33
references: 16380711
references: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
references: 16381832
references: Cell. 2004 Jan 23;116(2):281-97
references: 14744438
references: Methods. 2007 Oct;43(2):153-61
references: 17889803
references: Oncogene. 2007 May 31;26(26):3769-76
references: 17173072
references: Nature. 2005 Mar 17;434(7031):338-45
references: 15735639
references: Nature. 2008 Sep 4;455(7209):64-71
references: 18668037
references: Nat Protoc. 2008;3(4):563-78
references: 18388938
references: Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9740-4
references: 15210942
references: Cancer Genet Cytogenet. 2008 Feb;181(1):8-15
references: 18262046
references: Curr Med Chem. 2009;16(9):1047-61
references: 19275611
references: Nat Struct Mol Biol. 2009 Nov;16(11):1160-6
references: 19838187
references: Cell. 2006 Sep 22;126(6):1203-17
references: 16990141
references: Arthritis Rheum. 2008 Apr;58(4):1001-9
references: 18383392
references: RNA. 2006 Sep;12(9):1747-52
references: 16888321
references: Blood. 2009 Jan 8;113(2):412-21
references: 18941112
references: Genes Dev. 2008 Oct 15;22(20):2773-85
references: 18923076
references: Curr Opin Infect Dis. 2002 Jun;15(3):259-67
references: 12015460