title: Predictors for clinically relevant Gleason score upgrade in patients undergoing radical prostatectomy.
abstract: OBJECTIVE
  To evaluate clinical predictors for Gleason score upgrade (GSU) in radical prostatectomy (RP) specimen, especially in patients with 'very' low risk PCA (T1c and biopsy Gleason score ≤6 and PSA <10 ng/ml and ≤2 positive biopsy cores and PSA density <0.15).
  
  
  METHODS
  402 consecutive patients undergoing RP between 2004 and 2006, including a subgroup of 62 patients with 'very' low risk PCA, were examined. Patients were categorized for clinically relevant GSU (defined as upgrade into a higher PCA risk category). Parameters including number of biopsy cores obtained, positive biopsy cores, prostate weight, PSA, DRE and pathology department were evaluated for their role as predictors. Furthermore, GSU in RP specimen was analyzed for its impact on pT-stage.
  
  
  RESULTS
  Clinically relevant GSU occurred in 38.1% in the whole cohort and in 32.3% in the 'very' low risk PCA subgroup. Gleason score downgrade (GSD) occurred in 4.7%. Number of biopsy cores obtained and prostate weight were independent negative predictors of GSU in all 402 patients (P = 0.02 and P = 0.03, respectively). In the 'very' low risk group, only number of biopsy cores obtained revealed as an independent negative predictor of GSU (P = 0.02). PSA, DRE, number of positive cores or pathology department were not associated to GSU. In the 'very' low risk group, GSU was related with extracapsular tumor extension (P = 0.05).
  
  
  CONCLUSIONS
  Clinically relevant GSU in RP specimen is still a challenging problem. Increasing the number of biopsy cores lower this risk significantly. GSD is rare and thus of minor importance for treatment decisions.
authors: Department of Urology, University of Mainz, Germany.
authors: Christian
authors: C
authors: Thomas
authors: Karin
authors: K
authors: Pfirrmann
authors: Frauke
authors: F
authors: Pieles
authors: Alexander
authors: A
authors: Bogumil
authors: Rolf
authors: R
authors: Gillitzer
authors: Christoph
authors: C
authors: Wiesner
authors: Joachim W
authors: JW
authors: Thüroff
authors: Sebastian W
authors: SW
authors: Melchior