title: [Notch pathway: from development to regeneration of skeletal muscle].
abstract: In vertebrates, skeletal muscle is derived from mesodermal structures called somites. Myogenic progenitor cells that form skeletal muscles of the trunk and limbs are derived from the dermomyotome, the dorsal region of the somite. These cells enter the myogenic program by activating a set of four myogenic regulatory factors. During embryonic and fetal growth, muscle progenitor cells provide the source for muscle growth. Around birth, the muscle progenitor enters quiescence, and adopts a satellite cell position on muscle fibers, providing a pool of adult muscle stem cells. They are essential for the growth and regeneration of muscles. Among the mechanisms that control the maintenance of satellite cells properties, the Notch pathway plays a crucial role. In facts, this pathway is implicated from the early steps of somitogenesis and the development of skeletal muscles in the embryo. Furthermore, during ageing, Notch activity decreases which results in decreased muscle regeneration. Thus, the Notch pathway is a key regulator of muscle plasticity.
authors: CNRS URA 2578, département de biologie du développement, Institut Pasteur, 25, rue du Docteur Roux, 75015 Paris, France.
authors: Alicia
authors: A
authors: Mayeuf
authors: Frédéric
authors: F
authors: Relaix