title: p53 codon 72 polymorphism and the risk of esophageal cancer: a Korean case-control study.
abstract: The aim of this study was to assess whether p53 codon 72 polymorphism is associated with an increased risk of esophageal cancer (EC) in South Korea. We conducted a case-control study including 340 patients with EC, and 1700 controls. P53 codon 72 polymorphism was determined by real-time polymerase chain reaction. The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in EC were 39.4%, 45.6%, and 15.0%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively. Compared with the Arg/Arg genotype, the OR of the Arg/Pro genotype was 1.09 (95% CI = 0.85-1.41) and that of the Pro/Pro genotype was 1.47 (95% CI = 1.02-2.11) for EC overall. When adjusted by age, gender, and smoking status, the OR of the Arg/Pro genotype was 1.24 (95% CI = 0.92-1.67) and that of the Pro/Pro genotype was 1.77 (95% CI = 1.15-2.74) for EC overall. In never-smokers and ever-smokers, the OR of the Arg/Pro genotype was 0.59 (95% CI = 0.37-0.95) and 1.39 (95% CI = 1.00-1.91), respectively, and there was a significant difference in the homogeneity test (P= 0.011). We observed that the p53 codon 72 polymorphism was associated with an increased risk of EC in this Korean case-control study, and smoking status modified the association between the p53 codon 72 polymorphism and the risk of EC.
authors: Department of Preventive Medicine,Yanbian University College of Medicine, Yanji, Jilin Province, China.
authors: J-M
authors: JM
authors: Piao
authors: H N
authors: HN
authors: Kim
authors: H-R
authors: HR
authors: Song
authors: S-S
authors: SS
authors: Kweon
authors: J-S
authors: JS
authors: Choi
authors: J-Y
authors: JY
authors: Yoon
authors: I J
authors: IJ
authors: Chung
authors: S-H
authors: SH
authors: Kim
authors: M-H
authors: MH
authors: Shin