title: HRQoL questionnaire evaluation in lactose intolerant patients with adverse reactions to foods.
abstract: The occurrence of patients with gastrointestinal symptoms attributed either to food allergy or intolerance has significantly increased. Nevertheless, an accurate and detailed case history, a systematic evaluation and the outcomes of specific allergy tests to identify the offending foods, including "in vivo" and "in vitro" allergy tests, are often negative for food allergy and may indicate a lactose intolerance, which is a recurrent condition affecting about 50% of adults. The aims of our study were the following: (1) What is the real incidence of the food hypersensitivity and the primary lactose intolerance in patients with gastrointestinal symptoms, initially referred to allergy or food intolerance? (2) Does lactose intolerance affect the quality of life and compliance to the therapy program? We investigated 262 consecutive patients, 72 men and 190 women. An accurate and detailed history and clinical examination were completed to investigate the offending foods. The evaluation in each patient included: allergy tests, lactose H2 breath test (LHBT) and the HRQoL questionnaire. Five years after the diagnosis of lactose intolerance, a questionnaire on the persistence of gastrointestinal symptoms after lactose ingestion and the diet compliance was distributed. Our results demonstrate an high prevalence of lactose intolerance, more frequent in women; in these patients, bloating and diarrhea are the most reported symptoms. We observe only a significant positive correlation between adverse drug reaction (ADR) and LHBT+ patients, but not an augmented prevalence of food allergy and a negative impact on the HRQoL questionnaire of lactose intolerance.
authors: Clinical Sciences, University of Parma, Parma, Italy. erminia.ridolo@unipr.it
authors: Ridolo
authors: R
authors: Erminia
authors: Baiardini
authors: B
authors: Ilaria
authors: Meschi
authors: M
authors: Tiziana
authors: Peveri
authors: P
authors: Silvia
authors: Nouvenne
authors: N
authors: Antonio
authors: Dall'Aglio
authors: D
authors: Pierpaolo
authors: Borghi
authors: B
authors: Loris
references: Eur J Clin Invest. 2008 Aug;38(8):541-7
references: 18573099
references: Eur Ann Allergy Clin Immunol. 2009 Feb;41(1):3-16
references: 19496347
references: Allergy. 1997 Oct;52(10):1031-5
references: 9360758
references: Ann Allergy Asthma Immunol. 2005 Jul;95(1):26-32
references: 16095138
references: Med Klin (Munich). 2008 Jun 15;103(6):413-22; quiz 423-4
references: 18548211
references: Med Care. 1992 Jun;30(6):473-83
references: 1593914
references: Am Fam Physician. 2002 May 1;65(9):1855-6
references: 12018808
references: Aliment Pharmacol Ther. 1999 Sep;13(9):1227-33
references: 10468706
references: Clin Exp Allergy. 2007 May;37(5):651-60
references: 17456212
references: J Allergy Clin Immunol. 2006 Feb;117(2 Suppl Mini-Primer):S470-5
references: 16455349
references: Dig Liver Dis. 2006 Jun;38(6):437-8
references: 16574518
references: Pediatr Nurs. 2005 Nov-Dec;31(6):486-93
references: 16411542
references: Health Qual Life Outcomes. 2006 Aug 10;4:48
references: 16901348
references: Ann Allergy Asthma Immunol. 2002 Dec;89(6 Suppl 1):56-60
references: 12487206
references: Annu Rev Med. 2009;60:261-77
references: 18729729
references: J Epidemiol Biostat. 2001;6(3):305-16
references: 11437095
references: J Allergy Clin Immunol. 1989 Mar;83(3):683-90
references: 2926087
references: Dig Dis. 2008;26(2):96-103
references: 18431058