title: AKAPs: the architectural underpinnings of local cAMP signaling.
abstract: The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".
authors: Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
authors: Michael D
authors: MD
authors: Kritzer
authors: Jinliang
authors: J
authors: Li
authors: Kimberly
authors: K
authors: Dodge-Kafka
authors: Michael S
authors: MS
authors: Kapiloff
references: EMBO J. 1998 Apr 15;17(8):2246-60
references: 9545238
references: J Mol Cell Cardiol. 2011 Mar;50(3):451-9
references: 21147122
references: Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10140-5
references: 17537920
references: Circ Res. 2008 Oct 10;103(8):836-44
references: 18757829
references: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):295-9
references: 8552625
references: J Biol Chem. 2010 Sep 24;285(39):30304-15
references: 20634290
references: J Cell Biol. 2008 Oct 20;183(2):297-311
references: 18936250
references: J Cell Biol. 2007 Feb 12;176(4):521-33
references: 17296797
references: Neuron. 1997 Jul;19(1):185-96
references: 9247274
references: Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12557-62
references: 18711127
references: Circ Res. 2007 Apr 13;100(7):950-66
references: 17431197
references: Pharmacol Ther. 1991;50(1):123-45
references: 1653962
references: Neuron. 2007 Jul 19;55(2):261-75
references: 17640527
references: J Biol Chem. 2001 May 4;276(18):15192-9
references: 11278469
references: Mol Pharmacol. 2009 Nov;76(5):935-41
references: 19684092
references: Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20990-5
references: 18093912
references: Mol Cell Biol. 2007 Dec;27(23):8215-27
references: 17923693
references: J Biol Chem. 2010 May 7;285(19):14450-8
references: 20231277
references: Annu Rev Biochem. 2007;76:481-511
references: 17376027
references: Neurosignals. 2009;17(1):5-22
references: 18948702
references: EMBO J. 2001 Jun 1;20(11):2757-67
references: 11387209
references: Physiol Rev. 2009 Apr;89(2):411-52
references: 19342611
references: J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46
references: 16306226
references: EMBO J. 2001 Apr 17;20(8):1921-30
references: 11296225
references: J Biol Chem. 2005 Apr 15;280(15):15405-12
references: 15691829
references: Nature. 2009 Nov 12;462(7270):182-8
references: 19907488
references: Am J Physiol Renal Physiol. 2000 Sep;279(3):F400-16
references: 10966920
references: Nat Cell Biol. 2010 Dec;12(12):1242-9
references: 21102438
references: J Mol Biol. 2003 Jul 25;330(5):1117-29
references: 12860132
references: J Biol Chem. 2006 Nov 3;281(44):33537-53
references: 16940053
references: J Mol Cell Cardiol. 2010 Apr;48(4):600-8
references: 19944109
references: Structure. 2010 Feb 10;18(2):155-66
references: 20159461
references: Br J Pharmacol. 2009 Sep;158(1):50-60
references: 19371331
references: Sci Signal. 2010 Sep 28;3(141):ra70
references: 20876873
references: J Biol Chem. 2003 Aug 1;278(31):28849-55
references: 12754202
references: EMBO J. 1998 Apr 15;17(8):2261-72
references: 9545239
references: Exp Cell Res. 2005 Feb 15;303(2):388-99
references: 15652351
references: Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13093-8
references: 14569017
references: J Biol Chem. 2010 Apr 9;285(15):11078-86
references: 20106966
references: Mol Cell. 2005 Dec 9;20(5):661-72
references: 16337591
references: J Biol Chem. 1977 Jun 10;252(11):3854-61
references: 16921
references: J Biol Chem. 2009 Aug 28;284(35):23540-6
references: 19574217
references: PLoS One. 2010 Apr 23;5(4):e10325
references: 20428246
references: Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13835-40
references: 18772391
references: Mol Pharmacol. 2011 Mar;79(3):533-40
references: 21149637
references: Proc Natl Acad Sci U S A. 1979 Apr;76(4):1570-4
references: 221898
references: J Biol Chem. 2011 Mar 11;286(10):7925-7937
references: 21224381
references: J Mol Cell Cardiol. 2010 Feb;48(2):387-94
references: 19883655
references: Curr Biol. 2004 Aug 24;14(16):1436-50
references: 15324660
references: Res Commun Chem Pathol Pharmacol. 1977 Oct;18(2):283-90
references: 199922
references: Curr Biol. 2000 Apr 6;10(7):409-12
references: 10753752
references: Circ Res. 2008 Feb 1;102(2):e1-e11
references: 18174462
references: Circ Res. 2001 Feb 16;88(3):291-7
references: 11179196
references: J Biol Chem. 2009 Jan 16;284(3):1583-92
references: 18945669
references: Nature. 2005 Sep 22;437(7058):574-8
references: 16177794
references: J Biol Chem. 2002 Feb 8;277(6):4079-87
references: 11733497
references: J Biol Chem. 2009 Apr 3;284(14):9140-6
references: 19218243
references: EMBO Rep. 2007 Nov;8(11):1061-7
references: 17901878
references: Cell. 2005 Oct 7;123(1):25-35
references: 16213210
references: Arch Biochem Biophys. 2006 Dec 15;456(2):204-15
references: 16934740
references: Mol Pharmacol. 2002 Aug;62(2):193-9
references: 12130668
references: Circ Res. 2006 Apr 28;98(8):1081-8
references: 16556871
references: J Biol Chem. 1992 Aug 25;267(24):16816-23
references: 1512224
references: Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4586-91
references: 11904392
references: Biochem J. 2009 Oct 23;424(1):69-78
references: 19715558
references: J Mol Cell Cardiol. 2009 Sep;47(3):365-71
references: 19481088
references: J Biol Chem. 2011 Jan 7;286(1):530-41
references: 21056973
references: J Biol Chem. 2006 Jul 28;281(30):21535-21545
references: 16728392
references: J Am Coll Cardiol. 2010 Apr 6;55(14):1476-86
references: 20359598
references: J Biol Chem. 2001 Nov 23;276(47):44247-57
references: 11546812
references: Circ Res. 2010 Sep 17;107(6):747-56
references: 20671242
references: Physiol Rev. 2007 Jul;87(3):965-1010
references: 17615394
references: J Biol Chem. 1992 Jul 5;267(19):13376-82
references: 1618839
references: J Biol Chem. 2010 Sep 3;285(36):27632-40
references: 20581396
references: J Biol Chem. 2010 Apr 16;285(16):12344-54
references: 20139090
references: Mol Cell. 2006 Nov 3;24(3):383-95
references: 17081989
references: J Biol Chem. 1980 Jun 10;255(11):5113-9
references: 6154700
references: Biochem Soc Trans. 2007 Nov;35(Pt 5):931-7
references: 17956249
references: Mol Cell. 2008 Oct 24;32(2):169-79
references: 18951085
references: EMBO J. 2004 Jul 21;23(14):2811-20
references: 15229649
references: Biochim Biophys Acta. 2008 Jan;1784(1):16-26
references: 17996741
references: Circ Res. 2004 Jul 9;95(1):67-75
references: 15178638
references: Science. 2010 Mar 26;327(5973):1653-7
references: 20185685
references: Cell. 2007 Jul 27;130(2):247-58
references: 17662940
references: IUBMB Life. 2007 Mar;59(3):163-9
references: 17487687
references: Mol Cell. 2004 Sep 24;15(6):889-99
references: 15383279
references: J Biol Chem. 2008 Aug 8;283(32):22295-303
references: 18477567
references: Circ Res. 2011 Jan 21;108(2):176-83
references: 21127295
references: J Cell Sci. 1999 Aug;112 ( Pt 16):2725-36
references: 10413680
references: J Biol Chem. 1996 Jul 12;271(28):16526-34
references: 8663227
references: J Cell Sci. 2001 Sep;114(Pt 17):3167-76
references: 11590243
references: Circ Res. 2006 Nov 10;99(10):1084-91
references: 17038640
references: J Biol Chem. 2005 Sep 9;280(36):31347-52
references: 16002409
references: Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3322-7
references: 11248077
references: Neuron. 1998 May;20(5):1017-26
references: 9620705
references: Nat Struct Biol. 1999 Mar;6(3):222-7
references: 10074940
references: Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9986-90
references: 12904575
references: Science. 2002 Jan 18;295(5554):496-9
references: 11799244
references: Hypertens Res. 2007 Dec;30(12):1239-46
references: 18344630
references: Trends Biochem Sci. 2006 Jun;31(6):316-23
references: 16690317
references: Cell. 2000 May 12;101(4):365-76
references: 10830164
references: J Biol Chem. 1995 May 26;270(21):12481-4
references: 7759492
references: Sci Signal. 2008 Dec 23;1(51):ra18
references: 19109240
references: Eur J Cell Biol. 2006 Jul;85(7):693-7
references: 16466668
references: J Biol Chem. 1983 Sep 10;258(17):10233-9
references: 6309796
references: Mol Cell Biol. 2002 Nov;22(21):7603-13
references: 12370307
references: IUBMB Life. 2009 Apr;61(4):394-406
references: 19319965
references: Mol Cell. 2006 Sep 15;23(6):925-31
references: 16973443
references: Cell. 2009 Aug 21;138(4):760-73
references: 19703401