title: Oncogenic activity of MCM7 transforming cluster.
abstract: The miniature chromosome maintenance (MCM) complex is a group of proteins that are essential for DNA replication licensing and control of cell cycle progression from G1 to S phase. Recent studies suggest that MCM7 is overexpressed and amplified in a variety of human malignancies. MCM7 genome sequence contains a cluster of miRNA that has been shown to downregulate expression of several tumor suppressors including p21, E2F1, BIM and pTEN. The oncogenic potential of MCM7 and its embedded miRNA has been demonstrated vigorously in in vitro experiments and in animal models, and they appear to cooperate in initiation of cancer. MCM7 protein also serves as a critical target for oncogenic signaling pathways such as androgen receptor signaling, or tumor suppressor pathways such as integrin α7 or retinoblastoma signaling. This review analyzes the transforming activity and signaling of MCM7, oncogenic function of miRNA cluster that is embedded in the MCM7 genome, and the potential of gene therapy that targets MCM7.
authors: Jian-Hua Luo, Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, United States.
authors: Jian-Hua
authors: JH
authors: Luo
references: Cancer Res. 2008 Aug 1;68(15):6162-70
references: 18676839
references: Gastroenterology. 2009 May;136(5):1689-700
references: 19422085
references: Cancer Res. 2008 Oct 15;68(20):8191-4
references: 18922889
references: Mol Cell Biol. 1999 Dec;19(12):8003-15
references: 10567526
references: Anticancer Res. 2006 Mar-Apr;26(2A):1071-5
references: 16619508
references: Sci Signal. 2010 Apr 13;3(117):ra29
references: 20388916
references: Cancer Cell Int. 2009 Aug 12;9:21
references: 19674469
references: World J Surg. 2006 May;30(5):767-74
references: 16547620
references: J Biol Chem. 1997 Sep 26;272(39):24508-13
references: 9305914
references: Anticancer Res. 2008 Nov-Dec;28(6A):3763-9
references: 19189662
references: Mol Cell Biol. 1985 Apr;5(4):649-58
references: 2985964
references: Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2514-8
references: 7708676
references: Cancer Res. 2010 Jun 1;70(11):4375-84
references: 20460506
references: Mol Cell Biol. 1998 May;18(5):2748-57
references: 9566894
references: Oncogene. 2006 Jul 6;25(29):4027-32
references: 16518415
references: Histopathology. 2005 Mar;46(3):307-13
references: 15720416
references: Cancer Gene Ther. 2010 Oct;17(10):694-9
references: 20539323
references: Cancer Res. 2003 Dec 1;63(23):8173-80
references: 14678972
references: Science. 1992 Feb 14;255(5046):817-23
references: 1536007
references: Oncogene. 2006 Feb 16;25(7):1090-8
references: 16247466
references: Cancer Cell. 2008 Mar;13(3):272-86
references: 18328430
references: Bioessays. 1996 Mar;18(3):183-90
references: 8867732
references: Trends Biochem Sci. 1996 Mar;21(3):102-6
references: 8882583
references: Nucleic Acids Res. 1992 Nov 11;20(21):5571-7
references: 1454522
references: Int J Oncol. 2008 Aug;33(2):245-51
references: 18636144
references: J Am Acad Dermatol. 2009 May;60(5):808-13
references: 19389522
references: Am J Pathol. 2008 Dec;173(6):1758-67
references: 18988800
references: Mol Cell Biol. 2010 Feb;30(3):845-56
references: 19948884