title: Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264.
abstract: A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting antibiotic family.
authors: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors: Gavin
authors: G
authors: Carr
authors: Mohammad R
authors: MR
authors: Seyedsayamdost
authors: Josephine R
authors: JR
authors: Chandler
authors: E Peter
authors: EP
authors: Greenberg
authors: Jon
authors: J
authors: Clardy
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