title: Can Paneth cell metaplasia in cecum indicate the presence of colorectal epithelial neoplasia?
abstract: The main purpose of the present study was to investigate the relationship between the incidence of Paneth cells in cecal mucosa and the incidence of colorectal epithelial neoplasias. Using endoscopic biopsy specimens, obtained from cecum of 375 subjects in cases of total colonoscopy, we examined the incidence of Paneth cells in the cecal mucosa. In the present study, Paneth cells were present in the human cecal mucosa (47.7%, 179/375 subjects) regardless of age. Paneth cells were found more frequently in the subjects with colorectal epithelial neoplasia (57.3%, 90/157 subjects) than in the subjects without colorectal epithelial neoplasia (40.8%, 89/218 subjects) (p<0.01, chi(2) test). Our results suggest that the incidence of Paneth cells in cecal mucosa indicate some changes in the environment with tumorigenesis of the colorectal region according to the function of Paneth cells, proposed by other investigators.
authors: JUNTENDO UNIV,SCH MED,DEPT GASTROENTEROL,TOKYO 113,JAPAN. JAPAN SELF DEF FORCES CENT HOSP,DEPT INTERNAL MED,TOKYO 154,JAPAN. JUNTENDO UNIV,SCH MED,DEPT PATHOL 1,TOKYO 113,JAPAN.
authors: R
authors: R
authors: Wada
authors: S
authors: S
authors: Matsukuma
authors: H
authors: H
authors: Miwa
authors: K
authors: K
authors: Kondo
authors: N
authors: N
authors: Sato
authors: Y
authors: Y
authors: Hakozaki
authors: K
authors: K
authors: Ohba
authors: H
authors: H
authors: Abe
authors: N
authors: N
authors: Kuwabara
authors: K
authors: K
authors: Suda