title: Angiogenic markers in canine lymphoma tissues do not predict survival times in chemotherapy treated dogs.
abstract: Angiogenesis, which is essential for malignancies to progress, depends on various signalling proteins including vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptors 1 and 2 (VEGFR-1 and VEGFR-2). Microvessel density (MVD) is frequently used to evaluate angiogenesis. This study assessed the relationship between expression of VEGF, VEGFR-1 and VEGFR-2, MVD and the survival time in dogs with lymphoma. VEGF, VEGFR-1 and VEGFR-2 expression was evaluated immunohistochemically and microvessel profiles were counted in 34 lymphoma samples. Seventy-nine percent of the samples showed high VEGF expression and 62% were highly positive for VEGFR-1; VEGFR-2 immunoreactivity was mostly negative. Dogs treated with chemotherapy had a median survival time of 266days, but no significant relationships were found between overall survival time, MVD and expression of VEGF, VEGFR-1 or VEGFR-2. In this study, VEGF its receptors and the MVD were no prognostic factors in dogs with lymphoma.
authors: Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria. Birgitt.Wolfesberger@vetmeduni.ac.at
authors: B
authors: B
authors: Wolfesberger
authors: Z
authors: Z
authors: Tonar
authors: A
authors: A
authors: Fuchs-Baumgartinger
authors: I
authors: I
authors: Walter
authors: M
authors: M
authors: Skalicky
authors: K
authors: K
authors: Witter
authors: J G
authors: JG
authors: Thalhammer
authors: M
authors: M
authors: Pagitz
authors: M
authors: M
authors: Kleiter