title: Treatment of high-risk solid tumors of childhood with myeloablative chemotherapy and autologous stem cell transplantation.
abstract: Sixteen consecutive stem cell transplantations (SCT) were performed after myeloablative chemotherapy in patients with high-risk solid tumors of childhood. Seven patients received autologous bone marrow transplantation (ABMT), seven received peripheral blood stem cell transplantation (PBSCT) and two received ABMT + PBSCT. The progression-free survival was similar in three types of transplants (57% ABMT, 43% PBSCT vs. 50% ABMT + PBSCT). The rate of relapse in site of distant organs was also similar (57% ABMT, 57% PBSCT vs. 50% ABMT + PBSCT). There was no statistically significant difference in the hematopoietic recovery time between each group. PBSCT group had a significantly fewer days of food intolerance and a lower morbidity than ABMT group. The disease-free survival was 71% for neuroblastoma, 50% for small round cell tumors and 25% for rhabdomyosarcoma. Post-SCT therapy for possible reinfused tumor cells should be mandatory to decrease the frequency of relapse.
authors: KEIO UNIV,SCH MED,DEPT PEDIAT,SHINJUKU KU,TOKYO 160,JAPAN. KEIO UNIV,SCH MED,CTR BLOOD TRANSFUS,SHINJUKU KU,TOKYO 160,JAPAN.
authors: M
authors: M
authors: Endo
authors: J
authors: J
authors: Yokoyama
authors: H
authors: H
authors: Ikawa
authors: K
authors: K
authors: Watanabe
authors: M
authors: M
authors: Ueda
authors: M
authors: M
authors: Kitajima
authors: A
authors: A
authors: Kinoshita
authors: Y
authors: Y
authors: Kurosawa
authors: R
authors: R
authors: Tanosaki