title: Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats.
abstract: The hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague-Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl(4)-diminished activity of the antioxidant enzymes and reduced CCl(4)-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale.
authors: Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, People's Republic of China.
authors: Lan
authors: L
authors: Yang
authors: Cheng-zhang
authors: CZ
authors: Wang
authors: Jian-zhong
authors: JZ
authors: Ye
authors: Hai-tao
authors: HT
authors: Li