title: [The correlation between hyperinsulinemia and pulse wave velocity].
abstract: OBJECTIVE
  To study the correlation between hyperinsulinemia (HIns) and arteriosclerosis in one community in Beijing.
  
  
  METHODS
  Subjects who received arteriosclerosis screening in physical examination annually were studied. All subjects were received 75g oral glucose tolerance test (OGTT) to evaluate glucose metabolic level, and brachial-ankle pulse wave velocity (baPWV) examination to evaluate arteriosclerosis. The correlation between hyperinsulinemia and pulse wave velocity was analyzed.
  
  
  RESULTS
  Among all the 1046 subjects under investigation, baPWV of subjects with HIns was higher than subjects with normoinsulinemic (NIns) in different glucose metabolism status [normal glucose tolerance, (1381.2 ± 280.8) cm/s vs (1280.3 ± 218.7) cm/s; imparied glucose regulation, (1557.5 ± 319.3) cm/s vs (1474.7 ± 305.1) cm/s; diabetes, (1764.3 ± 476.6) cm/s vs (1664.2 ± 374.6) cm/s], especially in subjects with normal glucose tolerance (P < 0.01). The prevalence of cardiovascular risk factors in subjects with HIns was much higher than subjects with NIns (P < 0.01). Multiple logistic regression analysis showed that hyperinsulinemia was the risk factor of arteriosclerosis, and the OR (95%CI) of subjects with HIns was 1.91 (1.169 - 3.105, P < 0.01) as compared to the subjects with NIns.
  
  
  CONCLUSIONS
  The subjects with HIns suffered from much more metabolic risk factors than NIns. Hyperinsulinemia that closely correlated with baPWV was a risk factor of arteriosclerosis.
authors: Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
authors: Fu-Sheng
authors: FS
authors: Fang
authors: Hui
authors: H
authors: Tian
authors: Chun-Lin
authors: CL
authors: Li
authors: Min-Yan
authors: MY
authors: Liu
authors: Xin-Yu
authors: XY
authors: Miao
authors: Xiao-Ling
authors: XL
authors: Cheng