title: Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men.
abstract: BACKGROUND
  Adipocyte fatty acid-binding protein (A-FABP) has been reported to play critical roles in the development of atherosclerosis. We investigated whether an increased in plasma A-FABP level can be independently associated with the presence of coronary artery disease (CAD).
  
  
  METHODS
  Two hundred eleven consecutive male patients (mean age: 66 years, range: 33-87 years) were enrolled from inpatients who underwent coronary angiography. Age-matched male subjects (n = 211) having no evidence of CAD served as controls. Plasma A-FABP levels were measured by enzyme-linked immunosorbent assays.
  
  
  RESULTS
  Plasma A-FABP levels in CAD patients were significantly higher than in control subjects (median [IQR], 20.6 [15.7-27.8] ng/mL vs. 15.1 [11.7-19.9] ng/mL, p < 0.01). Multivariate logistic regression analysis revealed that an increased plasma A-FABP level was independently associated with the presence of CAD in all subjects (adjusted odds ratio: 1.76, 95% confidence interval: 1.14 to 2.70, p = 0.01). Furthermore, sub-analysis based on age showed that this association remained significant in subjects aged < 65 years (adjusted odds ratio: 3.06, 95% confidence interval: 1.34 to 6.98, p < 0.01), but not in subjects aged ≥65 years.
  
  
  CONCLUSIONS
  Increased plasma A-FABP in non-elderly men had a significant association with the presence of CAD, independent of established CAD risk factors.
authors: Department of Cardiology, Kagawa Prefectural Central Hospital, Kagawa, Japan.
authors: Masayuki
authors: M
authors: Doi
authors: Toru
authors: T
authors: Miyoshi
authors: Satoshi
authors: S
authors: Hirohata
authors: Kazufumi
authors: K
authors: Nakamura
authors: Shinichi
authors: S
authors: Usui
authors: Ko
authors: K
authors: Takeda
authors: Mutsumi
authors: M
authors: Iwamoto
authors: Shozo
authors: S
authors: Kusachi
authors: Kengo
authors: K
authors: Kusano
authors: Hiroshi
authors: H
authors: Ito
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