title: The value of Carlsson-dent questionnaire in diagnosis of gastroesophageal reflux disease in area with low prevalence of gastroesophageal reflux disease.
abstract: OBJECTIVE
  Symptom-based diagnosis for gastroesophageal reflux disease (GERD) has been accepted in the population with high prevalence. Carlsson-Dent questionnaire (CDQ) is a standardized symptom-based diagnosis tool for GERD. The value of this tool in the population with low prevalence is unknown. The aim of this study was to determine CDQ performance for diagnosis of GERD in Thai population with low prevalence versus endoscopy or 24 hour pH monitoring.
  
  
  METHODS
  Patients with dyspepsia by Rome II criteria were recruited. All patients completed a Thai version of CDQ and underwent endoscopic examination. Those without esophagitis or peptic ulcer and positive CDQ score took pH monitoring.
  
  
  RESULTS
  One hundred patients (68 female) with mean age ± SD of 45.6 ± 12.4 years were recruited. Six with Los Angeles grade A esophagitis had negative CDQ score. In 44 with positive CDQ score, 3 had Los Angeles grade B esophagitis and 41 had pH monitoring done with 8 having positive test. The GERD diagnosis by CDQ was confirmed in 11 of 44 patients (25%). CDQ detected 11 out of 17 GERD detected by endoscopy and pH monitoring and the sensitivity of CDQ was 64%.
  
  
  CONCLUSIONS
  CDQ diagnosed more GERD in Thai population with low prevalence compared with endoscopy and pH monitoring. This may be due to some patients with functional heartburn were picked up by CDQ and some patients with GERD were not detected by endoscopy and pH monitoring.
authors: NKC Institute of Gastroenterology and Hepatology, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, Thailand.
authors: Nisa
authors: N
authors: Netinatsunton
authors: Siriboon
authors: S
authors: Attasaranya
authors: Bancha
authors: B
authors: Ovartlarnporn
authors: Sulee
authors: S
authors: Sangnil
authors: Sopa
authors: S
authors: Boonviriya
authors: Teerha
authors: T
authors: Piratvisuth
references: J Gastroenterol Hepatol. 2008 Dec;23(12):1785-93
references: 19120871
references: J Clin Gastroenterol. 2007 May-Jun;41(5):437-44
references: 17450022
references: Gastroenterology. 2005 Nov;129(5):1756-80
references: 16285971
references: J Clin Gastroenterol. 2008 Jul;42(6):680-6
references: 18347510
references: J Gastroenterol Hepatol. 1998 Apr;13(4):335-53
references: 9641295
references: Am J Gastroenterol. 1974 Oct;62(4):325-32
references: 4432845
references: Aliment Pharmacol Ther. 2003 Jun 1;17(11):1407-13
references: 12786635
references: Aliment Pharmacol Ther. 2003 Apr;17(8):1049-55
references: 12694087
references: Aliment Pharmacol Ther. 2004 Oct 1;20(7):705-17
references: 15379831
references: J Gastrointest Surg. 2010 Mar;14(3):427-36
references: 20066567
references: J Neurogastroenterol Motil. 2011 Jan;17(1):14-27
references: 21369488
references: J Gastroenterol Hepatol. 2005 Apr;20(4):643-7
references: 15836717
references: J Gastroenterol. 2004 Sep;39(9):888-91
references: 15565409
references: Lancet. 1994 Dec 3;344(8936):1533-6
references: 7983953
references: World J Gastroenterol. 2004 Nov 15;10(22):3332-5
references: 15484311
references: Scand J Gastroenterol. 1998 Oct;33(10):1023-9
references: 9829354
references: Am J Gastroenterol. 2005 Oct;100(10):2324-37
references: 16181387
references: Gut. 1999 Aug;45(2):172-80
references: 10403727
references: Aliment Pharmacol Ther. 2009 Nov 15;30(10):1030-8
references: 19737151
references: Gut. 2004 May;53 Suppl 4:iv25-7
references: 15082610
references: Aliment Pharmacol Ther. 2004 Mar 1;19(5):463-79
references: 14987316
references: Gut. 2005 May;54(5):710-7
references: 15831922
references: Clin Gastroenterol Hepatol. 2006 Apr;4(4):398-407
references: 16616342
references: J Gastroenterol Hepatol. 2005 Dec;20(12):1900-5
references: 16336451