title: Expression of ras p21 and myc p64 oncoproteins in imprint smears of lung-cancer.
abstract: The expression of ras p21 and myc p64 was examined in imprint smears of 52 patients with lung cancer and 44 patients with benign disorders, by immunochemistry. Imprint smears were-taken from fresh bronchial biopsies during diagnostic bronchoscopy. Both ras and mye oncoproteins were found to give negative reaction in all benign examined cases; Of the 52 malignant bronchial tissue imprint smears, 28 (54%) and 30 (58%) were positively stained with ms p21 and mye p64 antibodies respectively. Positive staining of ras p21 was demonstrated in 54.5% of squamous cell carcinoma, in 80% of adenocarcinoma and in 0% of small cell carcinoma imprint smears. Positive staining of myc p64 was demonstrated in 45.4% of squamous cell carcinoma, in 50% of adeno-carcinoma and in 100% of small cell carcinoma. The results of this study indicate that both ras and myc oncoproteins detected in bronchial biopsies, may play a crucial role in lung cancer.
authors: UNIV ATHENS,DEPT CYTOL & CYTOGENET,GR-11527 ATHENS,GREECE.
authors: D
authors: D
authors: Orphanidou
authors: P
authors: P
authors: Athanasiadou
authors: M
authors: M
authors: Toumbis
authors: A
authors: A
authors: Rasidakis
authors: E
authors: E
authors: Petrakakou
authors: K
authors: K
authors: Kyrkou
authors: J
authors: J
authors: Jordanoglou