title: Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of moderate nasolabial folds: 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study.
abstract: BACKGROUND
  Hyaluronic acid (HA) fillers such as Restylane(®) are frequently used for the correction of facial soft tissue defects.
  
  
  OBJECTIVE
  To compare the efficacy and safety of a novel HA filler, Emervel(®) Classic, with those of Restylane in the treatment of moderate nasolabial folds.
  
  
  METHODS
  This was a split-face, randomized and evaluator-blinded comparison study. Subjects were randomized to receive an injection of Emervel Classic or Restylane on their left or right side. Efficacy was evaluated based on the change in Wrinkle Severity Rating Score (WSRS) from baseline. Local tolerability was assessed based on subject diary, which recorded the severity of erythema, oedema/swelling, bruising, pain/tenderness and pruritus during the first 3 weeks after injection.
  
  
  RESULTS
  The interim results 6 months after injection are reported. At week 24, the mean improvement in WSRS from baseline was 0.83 ± 0.51 for Emervel Classic, similar to that for Restylane (0.90 ± 0.57). A similar volume of both fillers was injected. Most local tolerability events were mild and transient. Erythema, oedema/swelling and pain/tenderness were significantly less severe and disappeared faster with Emervel Classic than with Restylane (at least p < 0.05).
  
  
  CONCLUSIONS
  Emervel Classic provides similar efficacy and better overall local tolerability compared with Restylane 6 months after treatment of moderate nasolabial folds.
authors: dEBM, Charité-Universitätsmedizin, Berlin, Germany. berthold.rzany@charite.de
authors: Berthold
authors: B
authors: Rzany
authors: Christiane
authors: C
authors: Bayerl
authors: Isaac
authors: I
authors: Bodokh
authors: Dominique
authors: D
authors: Boineau
authors: Thomas
authors: T
authors: Dirschka
authors: Catherine
authors: C
authors: Queille-Roussel
authors: Michael
authors: M
authors: Sebastian
authors: Boris
authors: B
authors: Sommer
authors: Michel
authors: M
authors: Poncet
authors: Mohammed
authors: M
authors: Guennoun
authors: Maurizio
authors: M
authors: Podda