title: Grading recommendations in clinical practice guidelines: randomised experimental evaluation of four different systems.
abstract: OBJECTIVE
  To evaluate the effect of presenting a recommendation in a clinical practice guideline using different grading systems to determine to what extent the system used changes the clinician's eventual response to a particular clinical question.
  
  
  METHODS
  Randomised experimental study.
  
  
  METHODS
  Clinician offices and academic settings.
  
  
  METHODS
  Paediatricians and paediatric residents in private and public practice in Mexico.
  
  
  METHODS
  Case notes of a child with diarrhoea and a question about clinician preference for using racecadotril. The same evidence was provided in a clinical recommendation but with different presentations according to the following grading systems: NICE (National Institute for Health and Clinical Excellence), SIGN (Scottish Intercollegiate Guideline Network), GRADE (Grading of Recommendations Assessment, Development and Evaluation) and CEBM (Centre for Evidence-Based Medicine, Oxford).
  
  
  METHODS
  Mean change in direction from baseline response (measured on a 10 cm visual scale and a Likert scale) and among groups.
  
  
  RESULTS
  216 subjects agreed to participate. Most participants changed their decision after reading the clinical recommendations (mean difference 0.7 cm, 95% CI 0.29 to 1.0; p<0.001). By groups, mean change (95% CI) from baseline was 0.04 (-0.68 to 0.77) for NICE, 0.31 (-0.41 to 1.05) for SIGN, 2.18 (1.48 to 2.88) for GRADE and 0.08 (-0.52 to 0.69) for CEBM (p=0.007 between groups). In a final survey, a small difference was noted regarding the clarity of the results presented with the GRADE system.
  
  
  CONCLUSIONS
  The clinician's decision to use a therapy was influenced most by the GRADE system.
  
  
  BACKGROUND
  NCT00940290.
authors: Centre for Evidence-Based Practice, Tecnológico de Monterrey, School of Medicine, Monterrey, Mexico. carlos.cuello@itesm.mx
authors: Carlos A
authors: CA
authors: Cuello García
authors: Karla P
authors: KP
authors: Pacheco Alvarado
authors: Giordano
authors: G
authors: Pérez Gaxiola