title: A tolerance gene for prenylated flavonoid encodes a 26S proteasome regulatory subunit in Sophora flavescens.
abstract: Yeast functional screening with a Sophora flavescens cDNA library was performed to identify the genes involved in the tolerant mechanism to the self-producing prenylated flavonoid sophoraflavanone G (SFG). One cDNA, which conferred SFG tolerance, encoded a regulatory particle triple-A ATPase 2 (SfRPT2), a member of the 26S proteasome subunit. The yeast transformant of SfRPT2 showed reduced SFG accumulation in the cells.
authors: Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, Kobe, Japan.
authors: Nobukazu
authors: N
authors: Shitan
authors: Yoshihisa
authors: Y
authors: Kamimoto
authors: Shota
authors: S
authors: Minami
authors: Mizuki
authors: M
authors: Kubo
authors: Kozue
authors: K
authors: Ito
authors: Masataka
authors: M
authors: Moriyasu
authors: Kazufumi
authors: K
authors: Yazaki