title: Biplane correlation imaging: a feasibility study based on phantom and human data.
abstract: The objective of this study was to implement and evaluate the performance of a biplane correlation imaging (BCI) technique aimed to reduce the effect of anatomic noise and improve the detection of lung nodules in chest radiographs. Seventy-one low-dose posterior-anterior images were acquired from an anthropomorphic chest phantom with 0.28° angular separations over a range of ±10° along the vertical axis within an 11 s interval. Similar data were acquired from 19 human subjects with institutional review board approval and informed consent. The data were incorporated into a computer-aided detection (CAD) algorithm in which suspect lesions were identified by examining the geometrical correlation of the detected signals that remained relatively constant against variable anatomic backgrounds. The data were analyzed to determine the effect of angular separation, and the overall sensitivity and false-positives for lung nodule detection. The best performance was achieved for angular separations of the projection pairs greater than 5°. Within that range, the technique provided an order of magnitude decrease in the number of false-positive reports when compared with CAD analysis of single-view images. Overall, the technique yielded ~1.1 false-positive per patient with an average sensitivity of 75%. The results indicated that the incorporation of angular information can offer a reduction in the number of false-positives without a notable reduction in sensitivity. The findings suggest that the BCI technique has the potential for clinical implementation as a cost-effective technique to improve the detection of subtle lung nodules with lowered rate of false-positives.
authors: Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University, Durham, NC 27710, USA. samei@duke.edu
authors: Ehsan
authors: E
authors: Samei
authors: Nariman
authors: N
authors: Majdi-Nasab
authors: James T
authors: JT
authors: Dobbins
authors: H Page
authors: HP
authors: McAdams
references: Perception. 1980;9(3):339-44
references: 7454514
references: IEEE Trans Med Imaging. 1998 Dec;17(6):872-80
references: 10048844
references: Chest. 2003 Aug;124(2):614-21
references: 12907551
references: Radiology. 2009 Jul;252(1):273-81
references: 19561261
references: Invest Radiol. 1978 May-Jun;13(3):175-81
references: 711391
references: Med Phys. 1990 Sep-Oct;17(5):866-75
references: 2233574
references: Acad Radiol. 1995 Nov;2(11):959-66
references: 9419667
references: Radiology. 1997 Jan;202(1):117-24
references: 8988200
references: AJR Am J Roentgenol. 2007 May;188(5):1239-45
references: 17449766
references: Lancet. 1999 Jul 10;354(9173):99-105
references: 10408484
references: Ann Thorac Surg. 1997 Feb;63(2):324-6
references: 9033294
references: Radiology. 1977 Jun;123(3):559-62
references: 860023
references: Radiol Clin North Am. 1996 May;34(3):565-96
references: 8657872
references: Radiographics. 1990 Jan;10(1):41-51
references: 2296696
references: Med Phys. 2008 Jun;35(6):2554-7
references: 18649488
references: Radiology. 2009 Apr;251(1):26-37
references: 19332844
references: Radiology. 1984 May;151(2):289-93
references: 6324279
references: Acad Radiol. 1996 Feb;3(2):129-36
references: 8796653
references: Med Phys. 1989 Jul-Aug;16(4):561-8
references: 2770630
references: Br J Radiol. 2004 Mar;77(915):231-5
references: 15020365
references: Phys Med Biol. 2003 Oct 7;48(19):R65-106
references: 14579853
references: IEEE Trans Med Imaging. 1993;12(4):664-9
references: 18218460
references: IEEE Trans Med Imaging. 2002 Feb;21(2):139-49
references: 11929101
references: Med Phys. 2003 Mar;30(3):387-94
references: 12674239
references: Radiology. 1975 Sep;116(3):527-32
references: 125436
references: Radiology. 1995 Feb;194(2):407-12
references: 7824718
references: J Digit Imaging. 1993 Feb;6(1):48-54
references: 8439583
references: Eur J Radiol. 2009 Nov;72(2):244-51
references: 19616909
references: IEEE Trans Pattern Anal Mach Intell. 1984 Jun;6(6):721-41
references: 22499653
references: IEEE Trans Med Imaging. 2001 Dec;20(12):1228-41
references: 11811823
references: Med Phys. 1988 Mar-Apr;15(2):158-66
references: 3386584
references: Radiology. 1983 Sep;148(3):609-15
references: 6308709
references: Br J Radiol. 2005;78 Spec No 1:S3-S19
references: 15917443
references: Invest Radiol. 1974 Nov-Dec;9(6):479-86
references: 4430588