title: Genetic players in multiple system atrophy: unfolding the nature of the beast.
abstract: Multiple system atrophy (MSA) is a fatal oligodendrogliopathy characterized by prominent α-synuclein inclusions resulting in a neuronal multisystem degeneration. Until recently MSA was widely conceived as a nongenetic disorder. However, during the last years a few postmortem verified Mendelian pedigrees have been reported consistent with monogenic disease in rare cases of MSA. Further, within the last 2 decades several genes have been associated with an increased risk of MSA, first and foremost the SNCA gene coding for α-synuclein. Moreover, genes involved in oxidative stress, mitochondrial dysfunction, inflammatory processes, as well as parkinsonism- and ataxia-related genes have been implicated as susceptibility factors. In this review, we discuss the emerging evidence in favor of genetic players in MSA.
authors: Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
authors: Sylvia
authors: S
authors: Stemberger
authors: Sonja W
authors: SW
authors: Scholz
authors: Andrew B
authors: AB
authors: Singleton
authors: Gregor K
authors: GK
authors: Wenning
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