title: Synthesis, and antitumor activity of some N1-(coumarin-7-yl) amidrazones and related congeners.
abstract: A series of new N1-(coumarin-7-yl)amidrazones incorporating N-piperazines and related congeners were synthesized by reacting the hydrazonoyl chloride derived from 7-amino-4-methylcoumarin with the appropriate piperazines. The chemical structures of the newly prepared compounds were supported by elemental analyses, ¹H-NMR, ¹³C-NMR, and ESI-HRMS spectral data. The antitumor activity of the newly synthesized compounds was evaluated. Among all the compounds tested, 7-{2-[1-(4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)piperazin-1-yl)-2-oxopropylidene]hydrazinyl}-4-methyl-2H-chromen-2-one (3n) was the most potent against MCF-7 and K562 cells, with IC₅₀ values of 20.2 and 9.3 μM, respectively.
authors: Department of Chemistry, The University of Jordan, Amman 11942, Jordan. mmubarak@ju.edu.jo
authors: Mohammad S
authors: MS
authors: Mustafa
authors: Mustafa M
authors: MM
authors: El-Abadelah
authors: Malek A
authors: MA
authors: Zihlif
authors: Randa G
authors: RG
authors: Naffa
authors: Mohammad S
authors: MS
authors: Mubarak
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