title: [Vitamin D3 in prevention of diseases in adults--a systematic review].
abstract: BACKGROUND
  Current evidence indicates that vitamin D3 plays significant role in calcium balance and bone metabolism through lifetime. There are also evidence on preventive efficacy of vitamin D3 in diabetes, insulin-resistance, hypertension and malignancy.
  
  
  METHODS
  The aim of the systematic review was to gather evidence regarding vitamin D3 in prevention of diseases in adults. MEDLINE via Pubmed was searched using key words: "vitamin D3, "prevention", "adults", "cardiovascular diseases", cancer", "osteoporosis", "common cold", "cold", "diabetes", "obesity", "depression". 26 trials were included into analysis: 17 randomized clinical trials, five observational studies, two systematic reviews, and two metaanalysis.
  
  
  RESULTS
  Vitamin D3 appears to has beneficial effect in depression therapy, protective effect on beta-cells in diabetic patients and reducing frequency of adverse events such as thrombosis in patients with prostate cancer. Supplementing with vitamin D3 results with no significant improve in reducing body weight, fat, blood pressure, risk of hypertension, level of lipids in serum, response to treatment in cancer prostate (together with dexamethasone and carboplatin). Many studies highlights beneficial influence of vitamin D3 with calcium on bone mineral density in whole body. Another studies show improve in bone mineral density in hips and pelvic bones only. There were inconsistencies of studies results regarding role of vitamin D3 in prevention of diabetes, risk of breast cancer and influence on bone mineral density.
  
  
  CONCLUSIONS
  Despite all inconsistencies supplementation of vitamin D3 is important and plays role in effective osteoporotic management and there is evidence on preventive efficacy of vitamin D3 in different diseases.
authors: Zakład Promocji Zdrowia, Instytut Zdrowia Publicznego, Wydział Nauk o Zdrowiu CM UJ w Krakowie. krzysieklach@poczta.fm
authors: Krzysztof
authors: K
authors: Łach
authors: Krzysztof
authors: K
authors: Krajewski-Siuda