title: One-pot stereoselective synthesis of 1,2-amino alcohol derivatives.
abstract: Common β-hydroxy amino acids (such as threonine) can be readily transformed into 1,2-amino alcohols with excellent stereoselectivity. This one-pot decarboxylation-alkylation process allows the replacement of the carboxyl group by alkyl, allyl, or aryl groups, generally in high yields. A variation of the process (decarboxylation-Diels-Alder) allows the formation of bi- and polycyclic systems, which are useful precursors of alkaloid cores or iminosugars.
authors: Instituto de Productos Naturales y Agrobiología CSIC, Avda. Astrofísico Fco. Sánchez 3, 38206-La Laguna, Tenerife, Spain. alicia@ipna.csic.es
authors: Alicia
authors: A
authors: Boto
authors: Iván
authors: I
authors: Romero-Estudillo