title: Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice.
abstract: BACKGROUND
  Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes. The first selective cannabinoid-1 receptor blocker rimonabant, an anorectic anti-obesity drug, was frequently used in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m(2) with associated risk factors such as type II diabetes and dyslipidaemia in the past. Less is known about the impact of this drug on the regulation of lipid metabolism in plasma and liver in the early stage of obesity.
  
  
  RESULTS
  We designed a four-week parallel controlled intervention on apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) transgenic mice with mild overweight and hypercholesterolemia. A liquid chromatography-linear ion trap-Fourier transform ion cyclotron resonance-mass spectrometric approach was employed to investigate plasma and liver lipid responses to the rimonabant intervention. Rimonabant was found to induce a significant body weight loss (9.4%, p<0.05) and a significant plasma total cholesterol reduction (24%, p<0.05). Six plasma and three liver lipids in ApoE*3Leiden.CETP transgenic mice were detected to most significantly respond to rimonabant treatment. Distinct lipid patterns between the mice were observed for both plasma and liver samples in rimonabant treatment vs. non-treated controls. This study successfully applied, for the first time, systems biology based lipidomics approaches to evaluate treatment effects of rimonabant in the early stage of obesity.
  
  
  CONCLUSIONS
  The effects of rimonabant on lipid metabolism and body weight reduction in the early stage obesity were shown to be moderate in ApoE*3Leiden.CETP mice on high-fat diet.
authors: CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
authors: Chunxiu
authors: C
authors: Hu
authors: Heng
authors: H
authors: Wei
authors: Anita M
authors: AM
authors: van den Hoek
authors: Mei
authors: M
authors: Wang
authors: Rob
authors: R
authors: van der Heijden
authors: Gerwin
authors: G
authors: Spijksma
authors: Theo H
authors: TH
authors: Reijmers
authors: Jildau
authors: J
authors: Bouwman
authors: Suzan
authors: S
authors: Wopereis
authors: Louis M
authors: LM
authors: Havekes
authors: Elwin
authors: E
authors: Verheij
authors: Thomas
authors: T
authors: Hankemeier
authors: Guowang
authors: G
authors: Xu
authors: Jan
authors: J
authors: van der Greef
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