title: Functional consequences of bidirectional promoters.
abstract: Several studies have shown that promoters of protein-coding genes are origins of pervasive non-coding RNA transcription and can initiate transcription in both directions. However, only recently have researchers begun to elucidate the functional implications of this bidirectionality and non-coding RNA production. Increasing evidence indicates that non-coding transcription at promoters influences the expression of protein-coding genes, revealing a new layer of transcriptional regulation. This regulation acts at multiple levels, from modifying local chromatin to enabling regional signal spreading and more distal regulation. Moreover, the bidirectional activity of a promoter is regulated at multiple points during transcription, giving rise to diverse types of transcripts.
authors: Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
authors: Wu
authors: W
authors: Wei
authors: Vicent
authors: V
authors: Pelechano
authors: Aino I
authors: AI
authors: Järvelin
authors: Lars M
authors: LM
authors: Steinmetz
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