title: Estrogen promotes benzo[a]pyrene-induced lung carcinogenesis through oxidative stress damage and cytochrome c-mediated caspase-3 activation pathways in female mice.
abstract: Estrogen may contribute to the development of smoking-induced lung cancer in women. To test this hypothesis, an mouse model was used to investigate the effects of 17 beta-estradiol (E2) on benzo[a]pyrene (B[a]P)-induced lung carcinogenesis. We found that B[a]P could cause oxidative stress damage, upregulate mitochondrial cytochrome-c and caspase-3 expression, induce lung carcinogenesis in female mice, E2 promoted these effects of B[a]P while tamoxifen (TAM) inhibited this effects of E2. We conclude that E2 can promote the tumorigenic effects of B[a]P in female mice, and oxidative stress damage and activation of cytochrome-c-mediated caspase-3 pathway may be involved in this process.
authors: Department of Health and Environment, Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment & Food Safety, Tianjin, PR China.
authors: Zhaoli
authors: Z
authors: Chen
authors: Yunxiao
authors: Y
authors: Zhang
authors: Jie
authors: J
authors: Yang
authors: Min
authors: M
authors: Jin
authors: Xin-Wei
authors: XW
authors: Wang
authors: Zhi-Qiang
authors: ZQ
authors: Shen
authors: Zhigang
authors: Z
authors: Qiu
authors: Guofan
authors: G
authors: Zhao
authors: Jingfeng
authors: J
authors: Wang
authors: Jun-Wen
authors: JW
authors: Li