title: The characterization of cell line crl-2335 as a Basal-like breast carcinoma model.
abstract: Basal-like breast cancer has been reported to be the most aggressive and deadly carcinoma sub-type. Patients diagnosed with this subtype have a less than 50% five-year survival. In addition, many studies have reported that this sub-type is more prevalent in specific ethnic groups and is believed to be a key factor that drives certain ethnic disparities in mortality. In order to effectively study this sub-type and determine unique gene expression and biochemical pathways which sustain this cancer's growth, we sought to identify human breast cancer cell lines that represent a model for the basal-like subtype. Here, we report our findings which indicate the African American cell line CRL-2335 is a true representative of basal-like breast carcinoma.
authors: Department of Genetics at the University of Georgia, 500 DW Brooks Drive, Athens, GA 30602, USA.
authors: Lori A
authors: LA
authors: Hill Neves
authors: Lishann
authors: L
authors: Ingram
authors: Melissa B
authors: MB
authors: Davis
references: Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23
references: 12829800
references: Int J Cancer. 1998 Dec 9;78(6):766-74
references: 9833771
references: Mol Cancer Ther. 2011 Mar;10(3):550-7
references: 21252285
references: Nature. 2000 Aug 17;406(6797):747-52
references: 10963602
references: Breast Cancer Res Treat. 2011 Feb;125(3):627-36
references: 21161370
references: Clin Cancer Res. 2004 Aug 15;10(16):5367-74
references: 15328174
references: Cancer Treat Rev. 2010 Nov;36 Suppl 3:S80-6
references: 21129616
references: Cancer Genet Cytogenet. 2010 Dec;203(2):222-9
references: 21156237
references: J Clin Oncol. 2009 Sep 20;27(27):4515-21
references: 19704069
references: J Pathol. 2005 Jan;205(2):248-54
references: 15641021
references: BMC Cancer. 2010 Sep 23;10:507
references: 20860845
references: Mol Oncol. 2011 Feb;5(1):5-23
references: 21147047
references: Breast Cancer (Auckl). 2010 May 20;4:35-41
references: 20697531
references: Eur J Cancer. 2008 Dec;44(18):2799-805
references: 19008097
references: J Natl Med Assoc. 2008 Jun;100(6):698-702
references: 18595572
references: Clin Cancer Res. 2010 Dec 15;16(24):6100-10
references: 21169259
references: Cancer. 2007 May 1;109(9):1721-8
references: 17387718
references: Br J Cancer. 2008 Jan 29;98(2):277-81
references: 18182985
references: Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74
references: 11553815
references: JAMA. 1994 Sep 28;272(12):947-54
references: 8084062
references: JAMA. 2006 Jun 7;295(21):2492-502
references: 16757721
references: Breast Cancer Res Treat. 2002 Jun;74(3):199-211
references: 12206512