title: Molecular mechanisms and clinical applications of angiogenesis.
abstract: Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish diseases such as cancer. Over the past decade, our understanding of the molecular mechanisms of angiogenesis (blood vessel growth) has increased at an explosive rate and has led to the approval of anti-angiogenic drugs for cancer and eye diseases. So far, hundreds of thousands of patients have benefited from blockers of the angiogenic protein vascular endothelial growth factor, but limited efficacy and resistance remain outstanding problems. Recent preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
authors: Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven B-3000, Belgium. peter.carmeliet@vib-kuleuven.be
authors: Peter
authors: P
authors: Carmeliet
authors: Rakesh K
authors: RK
authors: Jain
references: Nat Med. 2001 Sep;7(9):987-9
references: 11533692
references: Circ Res. 2009 Mar 13;104(5):576-88
references: 19286613
references: Nat Rev Mol Cell Biol. 2002 Dec;3(12):932-43
references: 12461559
references: Cold Spring Harb Perspect Biol. 2010 May;2(5):a001875
references: 20452960
references: Nat Cell Biol. 2010 Oct;12(10):943-53
references: 20871601
references: Cancer Cell. 2005 Sep;8(3):211-26
references: 16169466
references: J Clin Invest. 2003 May;111(9):1287-95
references: 12727920
references: Nat Med. 2010 Apr;16(4):420-8
references: 20364125
references: Nat Rev Cancer. 2007 May;7(5):327-31
references: 17457300
references: Nature. 2010 Feb 11;463(7282):E6-7
references: 20147986
references: J Mol Med (Berl). 2008 Feb;86(2):135-44
references: 17891366
references: Clin Cancer Res. 2011 Apr 15;17(8):2074-80
references: 21349998
references: Cancer Cell. 2009 Mar 3;15(3):232-9
references: 19249681
references: J Cell Mol Med. 2008 Dec;12(6B):2533-51
references: 19210754
references: Cell. 2010 Jan 22;140(2):268-79
references: 20141840
references: Nat Cell Biol. 2000 Oct;2(10):737-44
references: 11025665
references: Annu Rev Pathol. 2007;2:251-75
references: 18039100
references: Cancer Cell. 2010 Dec 14;18(6):630-40
references: 21130043
references: Nat Rev Drug Discov. 2009 Mar;8(3):235-53
references: 19247306
references: Nature. 2008 Dec 11;456(7223):814-8
references: 18997773
references: Cancer Res. 2004 Nov 15;64(22):8249-55
references: 15548691
references: Cancer Cell. 2006 Mar;9(3):225-38
references: 16530706
references: J Clin Oncol. 2011 Jan 1;29(1):83-8
references: 21098326
references: J Clin Invest. 2007 Aug;117(8):2114-22
references: 17641778
references: Basic Res Cardiol. 2011 Jan;106(1):5-11
references: 21184089
references: Cell. 2002 May 31;109(5):625-37
references: 12062105
references: Trends Cell Biol. 2010 Sep;20(9):556-67
references: 20656490
references: J Clin Oncol. 2010 May 1;28(13):2144-50
references: 20368553
references: Cytokine Growth Factor Rev. 2010 Feb;21(1):21-6
references: 20005148
references: Cancer Cell. 2008 Mar;13(3):206-20
references: 18328425
references: Nat Rev Cancer. 2008 Dec;8(12):942-56
references: 19029957
references: Histol Histopathol. 2010 Jun;25(6):765-70
references: 20376783
references: Dev Cell. 2009 Oct;17(4):505-15
references: 19853564
references: Cancer Cell. 2010 Aug 9;18(2):171-84
references: 20708158
references: Curr Opin Cell Biol. 2008 Oct;20(5):514-9
references: 18638550
references: Semin Cancer Biol. 2009 Oct;19(5):318-28
references: 19482089
references: Mol Cancer Ther. 2008 Aug;7(8):2272-9
references: 18687659
references: Circ Res. 2010 Oct 15;107(8):943-52
references: 20947863
references: Eur Cytokine Netw. 2009 Dec;20(4):158-63
references: 20167554
references: Neuron. 2010 Nov 4;68(3):321-3
references: 21040834
references: Science. 2005 Jan 7;307(5706):58-62
references: 15637262
references: Nat Rev Cancer. 2008 Aug;8(8):592-603
references: 18650835
references: Cancer Res. 2011 Jan 1;71(1):19-28
references: 21199795
references: Science. 2010 Nov 12;330(6006):985-9
references: 21071672
references: Cancer Cell. 2009 Mar 3;15(3):220-31
references: 19249680
references: Nat Clin Pract Oncol. 2006 Jan;3(1):24-40
references: 16407877
references: Nature. 2010 Dec 9;468(7325):829-33
references: 21102433
references: Dev Cell. 2010 Jun 15;18(6):938-49
references: 20627076
references: Nat Rev Cancer. 2009 Apr;9(4):239-52
references: 19279573
references: Cell. 2010 Feb 19;140(4):460-76
references: 20178740
references: Cancer Res. 2009 May 15;69(10):4527-36
references: 19401451
references: Nature. 2005 Dec 8;438(7069):820-7
references: 16341007
references: Nat Rev Cancer. 2008 Aug;8(8):632-45
references: 18580951
references: Basic Res Cardiol. 2009 Jan;104(1):5-21
references: 19101749
references: Cancer Res. 2011 Jan 1;71(1):143-53
references: 21084271
references: Mol Cell. 2010 Oct 22;40(2):294-309
references: 20965423
references: Nature. 2008 Feb 21;451(7181):1008-12
references: 18288196
references: J Clin Oncol. 2011 Jan 1;29(1):11-6
references: 20940184
references: Cancer Cell. 2011 Jan 18;19(1):31-44
references: 21215706
references: Nat Rev Cancer. 2010 Feb;10(2):138-46
references: 20094048
references: Nature. 2005 Dec 15;438(7070):932-6
references: 16355210
references: Nature. 2010 May 27;465(7297):487-91
references: 20445540
references: Nat Cell Biol. 2008 May;10(5):527-37
references: 18425119
references: J Oncol. 2010;2010:135285
references: 20224755
references: Cancer Cell. 2009 Jan 6;15(1):21-34
references: 19111878
references: Dev Cell. 2009 Feb;16(2):167-79
references: 19217420
references: Science. 2009 Oct 9;326(5950):294-8
references: 19815777
references: Dev Cell. 2009 Feb;16(2):222-31
references: 19217424
references: Nat Rev Cancer. 2010 Jan;10(1):9-22
references: 20029421
references: N Engl J Med. 2009 Jul 23;361(4):358-67
references: 19587327
references: Biochim Biophys Acta. 2010 Jan;1803(1):103-20
references: 19800930
references: Cell. 2009 Jun 12;137(6):1124-35
references: 19524514
references: Cancer. 2010 Feb 15;116(4 Suppl):1027-32
references: 20127948
references: Cancer Res. 2010 Jul 15;70(14):5670-3
references: 20587530
references: J Clin Invest. 2006 Oct;116(10):2610-21
references: 17016557
references: Nat Rev Mol Cell Biol. 2009 Mar;10(3):165-77
references: 19234476
references: Cell. 2010 Apr 2;141(1):166-77
references: 20371352
references: Cancer Res. 2010 Jun 15;70(12):5109-15
references: 20501841
references: Dev Cell. 2009 Jan;16(1):70-82
references: 19154719
references: Arterioscler Thromb Vasc Biol. 2009 May;29(5):630-8
references: 19164813
references: Nat Rev Drug Discov. 2007 Apr;6(4):273-86
references: 17396134
references: Nat Rev Cancer. 2010 Aug;10(8):587-93
references: 20631803
references: Dev Cell. 2010 May 18;18(5):713-24
references: 20434959
references: Am J Pathol. 2009 Nov;175(5):2159-70
references: 19815705
references: Cell. 2009 Mar 6;136(5):839-851
references: 19217150
references: Dev Cell. 2009 Feb;16(2):196-208
references: 19217422
references: Nat Med. 2001 May;7(5):575-83
references: 11329059
references: Nature. 2010 Apr 22;464(7292):1196-200
references: 20364122
references: Nat Rev Clin Oncol. 2009 Jun;6(6):327-38
references: 19483739
references: Dev Cell. 2009 Feb;16(2):209-21
references: 19217423
references: Nature. 2010 Apr 8;464(7290):917-21
references: 20228789
references: Cell. 2007 Aug 24;130(4):691-703
references: 17719546
references: Nat Cell Biol. 2005 Sep;7(9):870-9
references: 16113679
references: Circulation. 2010 Oct 26;122(17):1725-33
references: 20937974
references: Nat Med. 2003 Jun;9(6):685-93
references: 12778167
references: PLoS One. 2009;4(4):e5123
references: 19352490
references: J Clin Invest. 2008 Oct;118(10):3355-66
references: 18776942
references: Recent Results Cancer Res. 2010;180:103-14
references: 20033380
references: Cell. 2010 Apr 2;141(1):178-90
references: 20371353
references: Nat Med. 2003 Jun;9(6):653-60
references: 12778163