title: Expression and localization of matrix metalloproteinases and tissue inhibitors of metalloproteinases as a prognostic factor in advanced colorectal carcinomas.
abstract: To clarify the usefulness of matrix metallo-proteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) as prognostic factors in advanced colorectal carcinoma, the immunohistochemical expressions of MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1 and TIMP-2 were examined. Specimens were selected from 67 consecutive patients undergoing surgery for advanced colorectal carcinoma. The patterns of expression were compared with the prognoses of the patients. The patients with TIMP-2 expression in stroma adjacent to the tumor mass had better prognoses than those of the patients who had no TIMP-2 expression in normal stroma adjacent to the tumor (p<0.05), which probably acted as a block of cancer cell invasion. However, the expression of MMP-2, presumably acting as an antagonist to TIMP-2 was not related to the prognosis, and the MMP-1, MMP-2, MMP-3, MMP-9 and TIMP-1 expressions were not related to any clinicopathological factors examined.
authors: KANSAI MED UNIV,DEPT PATHOL 2,MORIGUCHI,OSAKA 570,JAPAN. KANSAI MED UNIV,DEPT SURG 2,MORIGUCHI,OSAKA 570,JAPAN.
authors: E
authors: E
authors: Ogura
authors: H
authors: H
authors: Senzaki
authors: Y
authors: Y
authors: Kiyozuka
authors: H
authors: H
authors: Takada
authors: K
authors: K
authors: Hioki
authors: A
authors: A
authors: Tsubura