title: Electrical conduction block in large nerves: high-frequency current delivery in the nonhuman primate.
abstract: Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.
authors: Cleveland FES Center, Hamman 601, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA. dma18@case.edu
authors: D Michael
authors: DM
authors: Ackermann
authors: Christian
authors: C
authors: Ethier
authors: Emily L
authors: EL
authors: Foldes
authors: Emily R
authors: ER
authors: Oby
authors: Dustin
authors: D
authors: Tyler
authors: Matt
authors: M
authors: Bauman
authors: Niloy
authors: N
authors: Bhadra
authors: Lee
authors: L
authors: Miller
authors: Kevin L
authors: KL
authors: Kilgore
references: IEEE Trans Neural Syst Rehabil Eng. 2010 Dec;18(6):658-65
references: 20813650
references: Neurorehabil Neural Repair. 2009 Jul-Aug;23(6):615-26
references: 19109445
references: Med Biol Eng Comput. 2004 May;42(3):394-406
references: 15191086
references: Med Biol Eng Comput. 2011 Feb;49(2):241-51
references: 20890673
references: IEEE Trans Neural Syst Rehabil Eng. 2009 Oct;17(5):469-77
references: 19840914
references: IEEE Trans Neural Syst Rehabil Eng. 2009 Dec;17(6):537-44
references: 19666341
references: J Urol. 2004 Nov;172(5 Pt 1):2069-72
references: 15540791
references: Appl Neurophysiol. 1986;49(3):121-38
references: 3827239
references: J Neural Eng. 2006 Jun;3(2):180-7
references: 16705274
references: IEEE Trans Biomed Eng. 2005 Mar;52(3):362-70
references: 15759566
references: Muscle Nerve. 2005 Dec;32(6):782-90
references: 16124008
references: J Neurosci Methods. 2010 Oct 30;193(1):72-6
references: 20705099
references: J Comput Neurosci. 2007 Jun;22(3):313-26
references: 17200886
references: J Physiol. 1935 Mar 15;83(4):407-15
references: 16994640
references: Muscle Nerve. 2010 Jan;41(1):117-9
references: 19813186
references: Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:614-7
references: 19963719