title: Leigh syndrome: MRI findings in two children.
abstract: Leigh syndrome is a progressive neurodegenerative disorder of childhood. The symmetrical necrotic lesions in the basal ganglia and/or brainstem which appear as hyperintense lesions on T2-weighted MRI is characteristic and one of the essential diagnostic criteria. Recognising this MR imaging pattern in a child with neurological problems should prompt the clinician to investigate for Leigh syndrome. We present here two cases of Leigh syndrome due to different biochemical/genetic defects, and discuss the subtle differences in their MR neuroimaging features.
authors: Department of Diagnostic Imaging, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.
authors: Al
authors: A
authors: Kartikasalwah
authors: Ngu
authors: N
authors: Lh
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