title: Enolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites-perspectives for its use as a therapeutic target.
abstract: Glycolysis and glyconeogenesis play crucial roles in the ATP supply and synthesis of glycoconjugates, important for the viability and virulence, respectively, of the human-pathogenic stages of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. These pathways are, therefore, candidate targets for antiparasite drugs. The glycolytic/gluconeogenic enzyme enolase is generally highly conserved, with similar overall fold and identical catalytic residues in all organisms. Nonetheless, potentially important differences exist between the trypanosomatid and host enzymes, with three unique, reactive residues close to the active site of the former that might be exploited for the development of new drugs. In addition, enolase is found both in the secretome and in association with the surface of Leishmania spp. where it probably functions as plasminogen receptor, playing a role in the parasite's invasiveness and virulence, a function possibly also present in the other trypanosomatids. This location and possible function of enolase offer additional perspectives for both drug discovery and vaccination.
authors: Laboratorio de Fisiología, Facultad de Ciencias, Universidad de los Andes, 5101 Mérida, Venezuela.
authors: Luisana
authors: L
authors: Avilán
authors: Melisa
authors: M
authors: Gualdrón-López
authors: Wilfredo
authors: W
authors: Quiñones
authors: Limari
authors: L
authors: González-González
authors: Véronique
authors: V
authors: Hannaert
authors: Paul A M
authors: PA
authors: Michels
authors: Juan-Luis
authors: JL
authors: Concepción
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