title: No need for systemic heparinization during laparoscopic donor nephrectomy with short warm ischemia time.
abstract: OBJECTIVE
  Systemic heparin administration during laparoscopic donor nephrectomy (LDN) may prevent microvascular thrombus formation following warm ischemia. We herein present our experience with and without systemic heparinization during LDN.
  
  
  METHODS
  We retrospectively reviewed donor complications and graft outcomes in 119 consecutive live donor kidney transplantations between January 2005 and December 2009. Systemic heparin was administered to the first 65 donors. LDN was carried out by 2 surgeons using a pure laparoscopic technique.
  
  
  RESULTS
  Total operating time for LDN was significantly longer in the heparin group (202 vs. 157 min). The incidence of renal artery multiplicity was significantly higher in the heparin group. Mean warm ischemia time was 160 s, and mean hospital stay was 5 days with no differences between groups. Postoperative hemorrhage occurred in 3 donors with systemic heparinization and in 1 without heparinization. Two donors received blood transfusions, and 2 underwent laparoscopic reexploration. Three grafts were lost in the heparin group and 1 in the non-heparin group. Graft loss was due to early vascular thrombosis (n = 3) and due to acute rejection (n = 1). Overall, 1-year graft survival was 96.6%, and 1-year serum creatinine was 1.41 mg/dl (P = n. s. between groups).
  
  
  CONCLUSIONS
  Abandoning systemic donor heparinization in LDN with short warm ischemia has a low complication rate without adverse effects on short- and long-term graft outcomes.
authors: Department of Urology, Charité Universitätsmedizin, Berlin, Germany. frank.friedersdorff@charite.de
authors: Frank
authors: F
authors: Friedersdorff
authors: Ingmar
authors: I
authors: Wolff
authors: Serdar
authors: S
authors: Deger
authors: Jan
authors: J
authors: Roigas
authors: John
authors: J
authors: Buckendahl
authors: Hannes
authors: H
authors: Cash
authors: Markus
authors: M
authors: Giessing
authors: Lutz
authors: L
authors: Liefeldt
authors: Kurt
authors: K
authors: Miller
authors: Tom Florian
authors: TF
authors: Fuller
authors: T
authors: T
authors: Florian Fuller
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