title: Effects of propranolol on the left ventricular volume of normal subjects during CT coronary angiography.
abstract: OBJECTIVE
  The purpose of this study is to determine the effects of propranolol on the left ventricular (LV) volume during CT coronary angiography.
  
  
  METHODS
  The LV volume of 252 normal Chinese subjects (126 subjects with propranolol medication and 126 age- and gender-matched Chinese subjects without medication) was estimated using 64 slices multi-detector CT (MDCT). The heart rate difference was analyzed by the logistic linear regression model with variables that included gender, age, body height, body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the dosage of propranolol. The following global LV functional parameters were calculated: the real-end diastolic volume (EDV), the real-end systolic volume (ESV) and the real-ejection fraction (EF).
  
  
  RESULTS
  The female subjects had a greater decrease of heart rate after taking propranolol. The difference of heart rate was negatively correlated with the dosage of propranolol. The real-EDV, the real-ESV and the real-EF ranged from 48.1 to 109 mL/m², 6.1 to 57.1 mL/m² and 41% to 88%, respectively. There was no significant difference in the SBP and DBP between the groups without and with propranolol medication (123 ± 17 and 80 ± 10 mmHg; 120 ± 14 and 80 ± 11 mmHg, respectively). The real-EDV showed no significant difference between these two groups, but the real-ESV and real-EF showed significant differences between these two groups (69.4 ± 9.3 and 70.6 ± 8.9 mL/m²; 23.5 ± 5.7 and 25.6 ± 3.7 mL/m², 66.5 ± 5.1% and 63.5 ± 4.6%, respectively).
  
  
  CONCLUSIONS
  The difference of heart rate is significantly influenced by gender and the dosage of propranolol. Propranolol will also increase the ESV, which contributes to a decreased EF, while the SBP, DBP and EDV are not statistically changed.
authors: Institute of Biomedical Engineering, College of Engineering and the College of Medicine, National Taiwan University, Taipei, Taiwan.
authors: Yuan Heng
authors: YH
authors: Mo
authors: Fu Shan
authors: FS
authors: Jaw
authors: Yung Cheng
authors: YC
authors: Wang
authors: Chin Ming
authors: CM
authors: Jeng
authors: Shinn Forng
authors: SF
authors: Peng
references: Acta Radiol. 2006 Dec;47(10):1049-57
references: 17135007
references: Circulation. 2006 Aug 15;114(7):654-61
references: 16894035
references: Int J Cardiol. 2008 Aug 1;128(1):69-76
references: 17692410
references: Am J Cardiol. 1989 Jan 15;63(3):166-71
references: 2909996
references: Eur Radiol. 2006 Sep;16(9):1964-72
references: 16699752
references: Clin Pharmacol Ther. 1999 Dec;66(6):594-601
references: 10613615
references: Am Heart J. 2006 Mar;151(3):736-44
references: 16504643
references: J Comput Assist Tomogr. 2006 Jul-Aug;30(4):555-63
references: 16845283
references: Circulation. 2005 Oct 11;112(15):2318-23
references: 16203914
references: Clin Pharmacol Ther. 1986 Jan;39(1):5-14
references: 2935349
references: Eur Radiol. 2008 Sep;18(9):1784-90
references: 18491100
references: Int J Cardiol. 2008 Sep 16;129(1):42-52
references: 17707526
references: J Am Coll Cardiol. 2005 Aug 2;46(3):552-7
references: 16053973
references: Eur Radiol. 2008 Mar;18(3):570-5
references: 17909817
references: Eur Heart J. 2005 Aug;26(15):1482-7
references: 15840624
references: AJR Am J Roentgenol. 2006 Jul;187(1):111-7
references: 16794164
references: Eur Radiol. 2008 Oct;18(10):2087-94
references: 18449547
references: Radiology. 2004 Feb;230(2):403-10
references: 14668428
references: J Nucl Cardiol. 2006 Jul;13(4):480-7
references: 16919571
references: Radiology. 2005 Feb;234(2):381-90
references: 15670995
references: Eur Radiol. 2006 Jul;16(7):1424-33
references: 16518654
references: Circulation. 2006 Oct 17;114(16):1761-91
references: 17015792
references: AJR Am J Roentgenol. 2007 Dec;189(6):1317-23
references: 18029865
references: Circ J. 2006 Mar;70(3):289-96
references: 16501295
references: J Med Primatol. 2007 Feb;36(1):39-46
references: 17359465
references: Eur Radiol. 2006 Feb;16(2):342-57
references: 16132917
references: Korean J Radiol. 2010 Jan-Feb;11(1):4-18
references: 20046490
references: J Med Assoc Thai. 2007 Mar;90(3):532-8
references: 17427532
references: J Nucl Med. 2006 Aug;47(8):1288-94
references: 16883007
references: Invest Radiol. 2008 May;43(5):284-9
references: 18424948
references: Int J Cardiovasc Imaging. 2008 Mar;24(3):317-25
references: 17701445
references: Circulation. 1980 Feb;61(2):358-66
references: 6101310
references: Acta Radiol. 2007 Feb;48(1):30-5
references: 17325922
references: Eur J Radiol. 2008 Sep;67(3):481-6
references: 17826936