title: A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures.
abstract: A new machine for conducting continuous flow processes at low temperatures on a laboratory scale is reported. The use of this cryogenic flow reactor has been demonstrated by the preparation of a variety of (hetero)aromatic boronic acids and esters via lithium halogen exchange chemistry. Furthermore, scale-up of the reaction conditions not only demonstrates the application of this device for the preparation of useful building blocks but also combines the ability to process n-butyllithium directly through pump heads attached to the unit.
authors: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
authors: Duncan L
authors: DL
authors: Browne
authors: Marcus
authors: M
authors: Baumann
authors: Bashir H
authors: BH
authors: Harji
authors: Ian R
authors: IR
authors: Baxendale
authors: Steven V
authors: SV
authors: Ley