title: Viral interleukin-10 expressed by human cytomegalovirus during the latent phase of infection modulates latently infected myeloid cell differentiation.
abstract: The human cytomegalovirus UL111A gene is expressed during latent and productive infections, and it codes for homologs of interleukin-10 (IL-10). We examined whether viral IL-10 expressed during latency altered differentiation of latently infected myeloid progenitors. In comparison to infection with parental virus or mock infection, latent infection with a virus in which the gene encoding viral IL-10 has been deleted upregulated cytokines associated with dendritic cell (DC) formation and increased the proportion of myeloid DCs. These data demonstrate that viral IL-10 restricts the ability of latently infected myeloid progenitors to differentiate into DCs and identifies an immunomodulatory role for viral IL-10 which may limit the host's ability to clear latent virus.
authors: Westmead Millennium Institute, Centre for Virus Research, P.O. Box 412, Westmead, New South Wales, Australia 2145.
authors: Selmir
authors: S
authors: Avdic
authors: John Z
authors: JZ
authors: Cao
authors: Allen K L
authors: AK
authors: Cheung
authors: Allison
authors: A
authors: Abendroth
authors: Barry
authors: B
authors: Slobedman
references: J Virol. 1994 Jun;68(6):4017-21
references: 8189535
references: Virology. 2009 Aug 1;390(2):330-7
references: 19524994
references: Transplant Proc. 2001 Feb-Mar;33(1-2):1822-3
references: 11267529
references: J Leukoc Biol. 1992 Sep;52(3):274-81
references: 1387891
references: Eur J Immunol. 1997 Dec;27(12):3135-42
references: 9464798
references: Blood. 1997 Sep 15;90(6):2482-91
references: 9310501
references: Cell Motil Cytoskeleton. 2004 Feb;57(2):118-32
references: 14691951
references: J Immunol. 1997 Feb 15;158(4):1591-7
references: 9029094
references: J Exp Med. 1989 Mar 1;169(3):1169-78
references: 2522497
references: J Immunol. 1993 Feb 1;150(3):821-34
references: 7678623
references: Blood. 1997 Aug 15;90(4):1425-34
references: 9269760
references: J Immunol. 1999 Nov 1;163(9):4869-77
references: 10528188
references: Future Microbiol. 2010 Jun;5(6):883-900
references: 20521934
references: J Virol. 2004 Feb;78(3):1440-7
references: 14722299
references: J Exp Med. 1994 Jul 1;180(1):83-93
references: 8006603
references: Immunology. 1994 Jul;82(3):487-93
references: 7525461
references: J Virol. 2009 Jun;83(11):5615-29
references: 19297488
references: Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11879-83
references: 7991550
references: Viral Immunol. 2006 Spring;19(1):92-101
references: 16553554
references: Chin Med J (Engl). 2005 Aug 5;118(15):1299-302
references: 16117886
references: J Virol. 2004 Aug;78(16):8720-31
references: 15280480
references: Blood. 2006 Dec 1;108(12):3691-9
references: 16931631
references: J Immunol. 1996 Aug 15;157(4):1499-507
references: 8759731
references: Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1695-700
references: 10677520
references: Microbes Infect. 1999 Dec;1(15):1283-90
references: 10611756
references: Scand J Immunol. 1998 Feb;47(2):116-21
references: 9496685
references: J Invest Dermatol. 2003 Dec;121(6):1397-401
references: 14675189
references: Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11137-42
references: 8855322
references: J Immunol. 1992 Oct 15;149(8):2681-8
references: 1383322
references: Virology. 2008 Apr 25;374(1):164-9
references: 18222515
references: Virology. 2000 Mar 15;268(2):272-80
references: 10704336
references: J Virol. 1999 Jun;73(6):4806-12
references: 10233941
references: Immunity. 2008 Sep 19;29(3):497-510
references: 18789730
references: Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12551-6
references: 9356487
references: BMJ. 1989 Oct 7;299(6704):897-8
references: 2555001
references: J Immunol. 2004 Sep 1;173(5):3383-91
references: 15322202
references: Yonsei Med J. 2000 Oct;41(5):642-50
references: 11079625
references: J Immunol Methods. 1996 Sep 27;196(2):137-51
references: 8841452
references: Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3937-42
references: 9520471
references: Proc Natl Acad Sci U S A. 2006 May 16;103(20):7783-8
references: 16672373
references: Cell. 1997 Oct 3;91(1):119-26
references: 9335340
references: Blood. 1990 Sep 15;76(6):1139-49
references: 2400808
references: J Exp Med. 1994 Apr 1;179(4):1109-18
references: 8145033
references: J Leukoc Biol. 1999 Nov;66(5):781-91
references: 10577510
references: J Virol. 2001 Aug;75(16):7543-54
references: 11462026
references: Virus Res. 2008 Feb;131(2):213-23
references: 17976852
references: J Virol. 2008 Apr;82(7):3736-50
references: 18216121
references: J Virol. 2005 Sep;79(17):11022-34
references: 16103153
references: J Virol. 1994 Mar;68(3):1597-604
references: 8107221
references: J Virol. 2003 Apr;77(8):4502-15
references: 12663757
references: J Virol. 2007 Feb;81(4):2083-6
references: 17121792
references: J Virol. 2009 Oct;83(19):9618-29
references: 19640997
references: J Gen Virol. 1991 Sep;72 ( Pt 9):2059-64
references: 1654370
references: Blood. 2004 Aug 1;104(3):687-95
references: 15090458
references: Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4140-5
references: 15738399
references: Nature. 1979 Nov 15;282(5736):324-6
references: 503208
references: Blood. 2009 Nov 5;114(19):4128-37
references: 19706889
references: J Gen Virol. 1996 Dec;77 ( Pt 12):3099-102
references: 9000102
references: Blood. 2007 Aug 1;110(3):937-45
references: 17440050
references: J Virol. 2004 Mar;78(6):2831-40
references: 14990702
references: Nature. 1997 Aug 21;388(6644):787-92
references: 9285592
references: Virology. 2009 Aug 15;391(1):20-4
references: 19564031