title: Effects of synthetic retinoid Am80 on iodide-induced autoimmune thyroiditis in nonobese diabetic mice.
abstract: We examined whether a synthetic retinoid Am80 prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic mice, an animal model of Hashimoto's thyroiditis (HT). Am80 (0, 0.1 or 1 mg/kg/day) was orally administered in feed during the 8-week iodide treatment. While iodide ingestion effectively induced thyroiditis, Am80 administration failed to interfere with thyroiditis development and serum anti-thyroglobulin antibody levels regardless of the dose of the retinoid. Splenic T cell numbers, splenocyte proliferation and interferon-γ production were decreased in the Am80-treated mice. Our data suggest that Am80 is not a candidate for use in the prevention of HT.
authors: Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. kokimori@yahoo.co.jp
authors: Kazuki
authors: K
authors: Morohoshi
authors: Katsumi
authors: K
authors: Yoshida
authors: Yoshinori
authors: Y
authors: Nakagawa
authors: Saeko
authors: S
authors: Hoshikawa
authors: Hiroshi
authors: H
authors: Ozaki
authors: Yurie
authors: Y
authors: Takahashi
authors: Sadayoshi
authors: S
authors: Ito
authors: Kouki
authors: K
authors: Mori