title: Antitumor effects of Doxorubicin hydrochloride (dox) and buthionine sulfoximine (bso)-hydroxyapatite (hap) complex on transplanted tumors in-vivo.
abstract: We prepared hydroxyapatite (HAP) beads containing doxorubicin hydrochloride (DOX) and buthionine sulfoximine (BSO), as a DOX and BSO-HAP complex. When the complex was implanted into mice bearing sarcoma 180 tumor, the antitumor effect of the complex was intensified 1.5-fold, as assessed using tumor volume, on day 27 as compared with that of a complex of DOX-HAP only. Therefore, we concluded that the antitumor effect of the DOX and BSO-HAP complex was increased through depletion of the intracellular radical scavenger glutathione (GSH) by released BSO and subsequently free radicals produced by released DOX.
authors: PL GAKUEN WOMENS JR COLL,DIV MOLEC LIFE SCI,OSAKA 584,JAPAN.
authors: M
authors: M
authors: Imamura
authors: T
authors: T
authors: Seki
authors: K
authors: K
authors: Kunieda
authors: M
authors: M
authors: Wakabayashi
authors: K
authors: K
authors: Inoue
authors: Y
authors: Y
authors: Obiya
authors: K
authors: K
authors: Harada