title: Altered central sensitization in subgroups of women with vulvodynia.
abstract: OBJECTIVE
  To investigate the clinical correlates of central nervous system alterations among women with vulvodynia. Altered central sensitization has been linked to dysfunction in central nervous system-inhibitory pathways (e.g., γ-aminobutyric acidergic), and metrics of sensory adaptation, a centrally mediated process that is sensitive to this dysfunction, could potentially be used to identify women at risk of treatment failure using conventional approaches.
  
  
  METHODS
  Twelve women with vulvodynia and 20 age-matched controls participated in this study, which was conducted by sensory testing of the right hand's index and middle fingers. The following sensory precepts were assessed: (1) vibrotactile detection threshold; (2) amplitude discrimination capacity (defined as the ability to detect differences in intensity of simultaneously delivered stimuli to 2 fingers); and (3) a metric of adaptation (determined by the impact that applying conditioning stimuli have on amplitude discriminative capacity).
  
  
  RESULTS
  Participants did not differ on key demographic variables, vibrotactile detection threshold, and amplitude discrimination capacity. However, we found significant differences from controls in adaptation metrics in 1 subgroup of vulvodynia patients. Compared with healthy controls and women with a shorter history of pain [n=5; duration (y) = 3.4 ± 1.3], those with a longer history [n=7; duration (y) = 9.3 ± 1.4)] were found to be less likely to have adaptation metrics similar to control values.
  
  
  CONCLUSIONS
  Chronic pain is thought to lead to altered central sensitization, and adaptation is a centrally mediated process that is sensitive to this condition. This report suggests that similar alterations exist in a subgroup of vulvodynia patients.
authors: Department of Biomedical Engineering, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors: Zheng
authors: Z
authors: Zhang
authors: Denniz A
authors: DA
authors: Zolnoun
authors: Eric M
authors: EM
authors: Francisco
authors: Jameson K
authors: JK
authors: Holden
authors: Robert G
authors: RG
authors: Dennis
authors: Mark
authors: M
authors: Tommerdahl
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