title: Low bone mass in microscopic colitis.
abstract: BACKGROUND
  Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis.
  
  
  OBJECTIVE
  The aim of the present study was to evaluate bone density and metabolism in patients with microscopic colitis.
  
  
  METHODS
  Fourteen patients microscopic colitis were included in the study, and 28 healthy persons and 28 age and gender matched Crohn's disease patients were enrolled as controls. Bone mineral density was measured using dual x-ray absorptiometry at the lumbar spine, femoral neck and the radius. Serum bone formation and bone resorption markers (osteocalcin and beta-crosslaps, respectively) were measured using immunoassays.
  
  
  RESULTS
  Low bone mass was measured in 57.14% patients with microscopic colitis. Bone mineral density at the femoral neck in patients suffering from microscopic colitis and Crohn's disease was lower than in healthy controls (0.852 ± 0.165 and 0.807 ± 0.136 vs. 1.056 ± 0.126 g/cm²; p < 0.01). Bone mineral density at the non-dominant radius was decreased in microscopic colitis patients (0.565 ± 0.093 vs. 0.667 ± 0.072 g/cm²; p < 0.05) but unaffected in Crohn's disease patients (0.672 ± 0.056 g/cm²). Mean beta-crosslaps concentration was higher in microscopic colitis and Crohn's disease patients than controls (417.714 ± 250.37 and 466.071 ± 249.96 vs. 264.75 ± 138.65 pg/ml; p < 0.05). A negative correlation between beta-crosslaps concentration and the femoral and radius t-scores was evident in microscopic colitis patients.
  
  
  CONCLUSIONS
  Low bone mass is frequent in microscopic colitis, and alterations to bone metabolism are similar to those present in Crohn's disease. Therefore, microscopic colitis-associated osteopenia could be a significant problem in such patients.
authors: 2nd Department of Medicine, Semmelweis University, Budapest, Hungary.
authors: Katalin
authors: K
authors: Lorinczy
authors: Gábor
authors: G
authors: Lakatos
authors: Katalin
authors: K
authors: Müllner
authors: István
authors: I
authors: Hritz
authors: Péter László
authors: PL
authors: Lakatos
authors: Zsolt
authors: Z
authors: Tulassay
authors: Pál
authors: P
authors: Miheller
references: Gut. 1987 Apr;28(4):410-5
references: 3583068
references: World Health Organ Tech Rep Ser. 1994;843:1-129
references: 7941614
references: Clin Orthop Relat Res. 1988 Jan;(226):267-91
references: 3275514
references: Lakartidningen. 2007 May 14-29;104(20-21):1597-8
references: 17564268
references: J Intern Med. 2000 Jan;247(1):63-70
references: 10672132
references: Pathol Eur. 1976;11(1):87-9
references: 934705
references: J Clin Invest. 1999 Oct;104(7):895-901
references: 10510330
references: Gut. 2004 Apr;53(4):536-41
references: 15016748
references: Aliment Pharmacol Ther. 1998 Jan;12(1):21-5
references: 9692696
references: Inflamm Bowel Dis. 2007 Nov;13(11):1379-84
references: 17663430
references: Osteoporos Int. 2010 Mar;21(3):365-72
references: 19495826
references: Inflamm Bowel Dis. 2000 Feb;6(1):8-15
references: 10701144
references: Dig Dis Sci. 2003 Dec;48(12):2323-7
references: 14714620
references: Dig Dis Sci. 1990 Feb;35(2):257-60
references: 2302984
references: Am J Gastroenterol. 1998 May;93(5):848-9
references: 9625151
references: Scand J Gastroenterol. 2001 Sep;36(9):959-62
references: 11521987
references: J Clin Gastroenterol. 1990 Jun;12(3):279-85
references: 2362097
references: World J Gastroenterol. 2008 Dec 28;14(48):7280-8
references: 19109861
references: Gastroenterology. 1976 Mar;70(3):439-44
references: 1248701
references: Orv Hetil. 2001 Jul 22;142(29):1557-60
references: 11494747
references: Gastroenterology. 1997 Jul;113(1):136-43
references: 9207271
references: Eur J Gastroenterol Hepatol. 2005 May;17(5):573-5
references: 15827449
references: Scand J Gastroenterol. 2002 Jun;37(6):711-4
references: 12126251
references: Clin Chem. 2001 Aug;47(8):1410-4
references: 11468230
references: Hum Pathol. 1989 Jan;20(1):18-28
references: 2912870
references: Cochrane Database Syst Rev. 2007 Jan 24;(1):CD006096
references: 17253579
references: Gastroenterology. 1992 Dec;103(6):1790-6
references: 1451972
references: Gastroenterology. 2003 Mar;124(3):795-841
references: 12612917
references: Ann Pathol. 2007 Dec;27(6):448-58
references: 18554555
references: Dig Dis. 2006;24(1-2):201-6
references: 16699279
references: J Clin Gastroenterol. 2009 Apr;43(4):293-6
references: 19169149
references: Aliment Pharmacol Ther. 2006 Feb 1;23(3):387-96
references: 16422998
references: World J Gastroenterol. 2009 Jul 7;15(25):3122-7
references: 19575491
references: BMC Gastroenterol. 2008 Oct 23;8:48
references: 18947388
references: Gastroenterology. 2003 Dec;125(6):1591-7
references: 14724810
references: Gut. 2005 Apr;54(4):479-87
references: 15753532