title: Transarterial embolisation of hepatocellular carcinoma with doxorubicin-eluting beads: single centre early experience.
abstract: OBJECTIVE
  This is a retrospective study to evaluate the results of our early experience of using doxorubicin eluting beads (DEB) to treat patients with early and intermediate hepatocellular carcinoma (HCC).
  
  
  METHODS
  A cohort of 19 patients (84.2% male; 15.8% female; mean age 59.2 years ± 11.0; range, 32-80 years) with documented HCC of size 1.8-10cm (mean, 4.0cm ± 1.8 ) undergoing DEB transarterial chembolisation (TACE) was reviewed. All patients had at least one image examination (multiphase computed tomography or magnetic resonance imaging) after embolisation.
  
  
  RESULTS
  A total of 32 procedures were performed. The objective response according to the European Association for the Study of the Liver criteria was 57.9% at 1-month, 42.8% at 6-month and 50.0% at 1-year follow up. There were 4 (21.1%) treatment-related complications (1 liver abscess, 2 pancreatitis and 1 tumour rupture) which resulted in 2 deaths. One death occurred 3 weeks after second embolisation, due to ruptured pancreatic pseudocyst, giving a 5.3% 30-day mortality rate. Another patient died 2 months after embolisation caused by tumour rupture. Eight patients received radiofrequency ablation after embolisation for residual or recurrent tumours. The 1-year survival rate in the DEB TACE only group was 80% while the 1- and 2-year survival rate in the group that received radiofrequency after DEB TACE was 85.7% and 100% respectively.
  
  
  CONCLUSIONS
  DEB TACE is safe and effective in select group of patients. Survival may be improved when combined with other treatment modality.
authors: Department of Biomedical Imaging, University of Malaya, Kuala Lumpur, Malaysia.
authors: O
authors: O
authors: Nawawi
authors: Mn
authors: M
authors: Hazman
authors: Bjj
authors: B
authors: Abdullah
authors: A
authors: A
authors: Vijayananthan
authors: J
authors: J
authors: Manikam
authors: S
authors: S
authors: Mahadeva
authors: Kl
authors: K
authors: Goh
references: Cardiovasc Intervent Radiol. 2007 Jan-Feb;30(1):6-25
references: 17103105
references: Eur Radiol. 2006 Mar;16(3):661-9
references: 16228211
references: J Hepatol. 2007 Jul;47(1):157-8; author reply 159
references: 17509721
references: Hepatology. 2002 May;35(5):1164-71
references: 11981766
references: Hepatogastroenterology. 2007 Jan-Feb;54(73):186-9
references: 17419257
references: Cardiovasc Intervent Radiol. 2008 Mar-Apr;31(2):269-80
references: 17999110
references: Clin Cancer Res. 2006 Apr 15;12(8):2563-7
references: 16638866
references: J Vasc Interv Radiol. 2006 Feb;17(2 Pt 1):217-23
references: 16517767
references: Radiology. 2002 Jul;224(1):47-54
references: 12091661
references: Hepatology. 1997 Nov;26(5):1156-61
references: 9362356
references: Clin Gastroenterol Hepatol. 2007 Sep;5(9):1100-8
references: 17627902
references: J Vasc Interv Radiol. 2006 Feb;17(2 Pt 1):335-42
references: 16517780
references: Lancet. 2003 Dec 6;362(9399):1907-17
references: 14667750
references: Semin Liver Dis. 1999;19(3):329-38
references: 10518312
references: Pancreatology. 2007;7(1):53-62
references: 17449966
references: Cardiovasc Intervent Radiol. 2008 May-Jun;31(3):468-76
references: 18228095
references: Digestion. 2007;75(2-3):104-12
references: 17598962
references: Hepatology. 2003 Feb;37(2):429-42
references: 12540794
references: N Engl J Med. 1995 May 11;332(19):1256-61
references: 7708069
references: AJR Am J Roentgenol. 1981 Aug;137(2):347-50
references: 6455049
references: J Vasc Interv Radiol. 2001 Mar;12(3):313-20
references: 11287508
references: Dig Dis Sci. 1993 Jan;38(1):65-70
references: 7678384
references: Semin Liver Dis. 1999;19(3):271-85
references: 10518307
references: World J Gastroenterol. 2005 Mar 14;11(10):1554-7
references: 15770737
references: Eur J Radiol. 2006 Sep;59(3):407-12
references: 16621394
references: Hepatobiliary Pancreat Dis Int. 2007 Feb;6(1):49-51
references: 17287166
references: Lancet. 2002 May 18;359(9319):1734-9
references: 12049862
references: Br J Surg. 1998 Apr;85(4):512-4
references: 9607536
references: J Hepatol. 2007 Mar;46(3):474-81
references: 17239480
references: Br J Radiol. 2001 Nov;74(887):983-6
references: 11709461
references: J Hepatol. 1998 Jul;29(1):129-34
references: 9696501
references: AJR Am J Roentgenol. 2001 Mar;176(3):681-8
references: 11222205
references: Nat Clin Pract Oncol. 2006 Jun;3(6):315-24
references: 16757969
references: J Hepatol. 2001 Sep;35(3):421-30
references: 11592607
references: Radiology. 1979 Apr;131(1):59-64
references: 218245
references: Malays J Pathol. 2003 Jun;25(1):37-43
references: 16196376
references: Cardiovasc Intervent Radiol. 2007 Jul-Aug;30(4):571-92
references: 17516113
references: Ann Chir. 2002 Dec;127(10):779-82
references: 12538100