title: Pharmacokinetics of levetiracetam in neonates with seizures.
abstract: The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.
authors: Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. stephanie.merhar@cchmc.org
authors: Stephanie L
authors: SL
authors: Merhar
authors: Kurt R
authors: KR
authors: Schibler
authors: Catherine M
authors: CM
authors: Sherwin
authors: Jareen
authors: J
authors: Meinzen-Derr
authors: Jing
authors: J
authors: Shi
authors: Tonya
authors: T
authors: Balmakund
authors: Alexander A
authors: AA
authors: Vinks
references: Epilepsia. 2002 May;43(5):518-24
references: 12027913
references: J Child Neurol. 2007 Jan;22(1):95-8
references: 17608315
references: Epilepsia. 2009 May;50(5):1141-9
references: 19243423
references: Seizure. 2005 Jun;14(4):248-53
references: 15911359
references: J Child Neurol. 2010 May;25(5):551-5
references: 20413804
references: Epilepsia. 2001 Dec;42(12):1574-9
references: 11879369
references: Epilepsia. 2007 Jun;48(6):1117-22
references: 17442002
references: N Engl J Med. 1990 Feb 8;322(6):364-9
references: 2242106
references: Drug Metab Pharmacokinet. 2009;24(1):25-36
references: 19252334
references: Seizure. 2007 Jun;16(4):345-50
references: 17368928
references: Eur J Paediatr Neurol. 2011 Jan;15(1):1-7
references: 21094062
references: Seizure. 2010 Apr;19(3):185-9
references: 20133173
references: Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15089-94
references: 12417760
references: Clin Pharmacokinet. 2004;43(11):707-24
references: 15301575
references: Pediatr Neurol. 2007 Aug;37(2):85-90
references: 17675022
references: Clin Chim Acta. 2007 Jan;375(1-2):115-8
references: 16914128