title: Disruption of ion homeostasis by verrucosin and a related compound.
abstract: We have found that (-)-virgatusin and related compounds have antimicrobial and antifungal activity. To identify further biological activities of these compounds, we tested the activity of acridine orange efflux, which shows ionophore-like disruption of cellular ion homeostasis activity. After testing 31 compounds, we found that verrucosin and a related compound had disruption activity.
authors: Integrated Center for Sciences (INCS), Ehime University, Matsuyama, Japan.
authors: Koichi
authors: K
authors: Akiyama
authors: Junichi
authors: J
authors: Tone
authors: Satoshi
authors: S
authors: Yamauchi
authors: Takuya
authors: T
authors: Sugahara
authors: Masafumi
authors: M
authors: Maruyama
authors: Yoshimi
authors: Y
authors: Kakinuma