title: Growth-control of human ovarian-carcinoma cells by insulin-like growth-factors.
abstract: The role of the insulin-like growth factors (IGFs) in 3 cultured human ovarian cancer cell lines (PEO1, PEO4, PEO14) was investigated. All three cell lines express mRNA for IGF-I and the PEO14 cell line expresses mRNA for IGF-II. Protein expression of IGF-II was demonstrated in the PEO14 and PEO4 cell lines. All 3 cell lines expressed mRNA for the IGF type I, IGF type II and insulin receptors; the presence of type I IGF receptors was confirmed by immuno-cytochemistry. IGF-I and insulin markedly stimulated the proliferation of PEO1 and PEO4 but not PEO14 cells while all 3 lines were insensitive to the addition of exogenous IGF-II.
authors: WESTERN GEN HOSP,IMPERIAL CANC RES FUND,MED ONCOL UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND. UNIV SURREY,SCH BIOL SCI,IMPERIAL CANC RES FUND,BREAST BIOL GRP,GUILDFORD GU2 5XH,SURREY,ENGLAND.
authors: J M
authors: JM
authors: Bartlett
authors: G J
authors: GJ
authors: Rabiasz
authors: W N
authors: WN
authors: Scott
authors: S P
authors: SP
authors: Langdon
authors: G L
authors: GL
authors: Hirst
authors: A
authors: A
authors: Lee
authors: J F
authors: JF
authors: Smyth
authors: W R
authors: WR
authors: Miller