title: Role of optical spectroscopy using endogenous contrasts in clinical cancer diagnosis.
abstract: Optical spectroscopy has been intensively studied for cancer management in the past two decades. This review paper first introduces the background of optical spectroscopy for cancer management, which includes the advantages of optical techniques compared to other established techniques, the principle of optical spectroscopy and the typical setup of instrumentation. Then the recent progress in optical spectroscopy for cancer diagnosis in the following organs is reviewed: the brain, breast, cervix, lung, stomach, colon, prostate and the skin. Reviewed papers were selected from the PubMed database with keywords combining the terms of individual optical spectroscopy techniques and cancers. The primary focus is on the in vivo applications of optical spectroscopy in clinical studies. Ex vivo studies are also included for some organs to highlight special applications or when there are few in vivo results in the literature. Practical considerations of applying optical spectroscopy in clinical settings such as the speed, cost, complexity of operation, accuracy and clinical value are discussed. A few commercially available clinical instruments that are based on optical spectroscopy techniques are presented. Finally several technical challenges and standard issues are discussed and firm conclusions are made.
authors: Quan Liu, Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, N1.3-B2-06, 70 Nanyang Drive, Singapore 637457, Singapore.
authors: Quan
authors: Q
authors: Liu
references: J Biomed Opt. 2006 Jul-Aug;11(4):044005
references: 16965162
references: Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19494-9
references: 18042710
references: NeuroRx. 2005 Apr;2(2):333-47
references: 15897954
references: Conf Proc IEEE Eng Med Biol Soc. 2004;2004:5285-8
references: 17271533
references: J Biomed Opt. 2008 Jan-Feb;13(1):014017
references: 18315375
references: Opt Lett. 2001 Nov 15;26(22):1782-4
references: 18059697
references: Int J Cancer. 2006 Jul 1;119(1):139-45
references: 16450394
references: Tumori. 2007 Nov-Dec;93(6):567-71
references: 18338491
references: Neurosurgery. 2005 Sep;57(3):518-25; discussion 518-25
references: 16145531
references: Med Phys. 2007 Nov;34(11):4309-21
references: 18072496
references: Faraday Discuss. 2004;126:141-57; discussion 169-83
references: 14992404
references: J Biophotonics. 2009 Feb;2(1-2):13-28
references: 19343682
references: Nat Rev Gastroenterol Hepatol. 2009 Jun;6(6):353-62
references: 19434097
references: Med Phys. 2003 Feb;30(2):235-47
references: 12607841
references: J Photochem Photobiol B. 2005 Jun 1;79(3):231-41
references: 15896650
references: Gastrointest Endosc. 2004 Feb;59(2):191-8
references: 14745391
references: Int J Cancer. 2010 Apr 15;126(8):1920-1927
references: 19816946
references: Photochem Photobiol. 2001 Feb;73(2):178-83
references: 11272732
references: J Neural Eng. 2008 Jun;5(2):185-90
references: 18460743
references: Biotechnol Annu Rev. 2005;11:191-225
references: 16216778
references: Radiology. 2001 Jan;218(1):261-6
references: 11152812
references: J Biomed Opt. 2008 Sep-Oct;13(5):054043
references: 19021423
references: Crit Rev Oncol Hematol. 2009 Dec;72(3):255-64
references: 19819161
references: Eur J Gastroenterol Hepatol. 2005 Aug;17(8):803-8
references: 16003127
references: Cancer. 2003 Nov 1;98(9 Suppl):2015-27
references: 14603538
references: Urol Clin North Am. 2006 May;33(2):133-46, v
references: 16631452
references: J Invest Dermatol. 2001 Dec;117(6):1452-7
references: 11886508
references: Annu Int Conf IEEE Eng Med Biol Soc. 2008;2008:1849-50
references: 19163043
references: Opt Lett. 2007 Apr 15;32(8):933-5
references: 17375158
references: Photochem Photobiol. 1998 Jan;67(1):15-22
references: 9477761
references: J Cancer Res Ther. 2008 Jan-Mar;4(1):26-36
references: 18417899
references: J Biomed Opt. 2009 Sep-Oct;14(5):050505
references: 19895101
references: Cancer Prev Res (Phila). 2010 Jul;3(7):844-51
references: 20570881
references: J Biomed Opt. 2000 Apr;5(2):221-8
references: 10938787
references: J Gastroenterol. 2009;44(11):1125-32
references: 19714289
references: Eur Urol. 2009 Feb;55(2):376-83
references: 18359147
references: Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:118-21
references: 19964924
references: Appl Opt. 2009 Apr 1;48(10):D280-98
references: 19340120
references: Int J Oncol. 2008 Mar;32(3):653-62
references: 18292943
references: Photochem Photobiol. 2001 Apr;73(4):396-402
references: 11332035
references: J Biomed Opt. 2009 Jan-Feb;14(1):014027
references: 19256715
references: Neoplasia. 2009 Apr;11(4):325-32
references: 19308287
references: Obstet Gynecol. 1999 Mar;93(3):462-70
references: 10075001
references: Urology. 2008 Aug;72(2):345-8
references: 18405945
references: Appl Opt. 1999 Nov 1;38(31):6628-37
references: 18324198
references: IEEE Trans Biomed Eng. 2009 Oct;56(10):2518-28
references: 19272976
references: Technol Cancer Res Treat. 2006 Jun;5(3):231-8
references: 16700619
references: Radiat Med. 2003 Jan-Feb;21(1):1-6
references: 12801137
references: Clin Obstet Gynecol. 2005 Mar;48(1):209-17
references: 15725873
references: Lung Cancer. 2007 Sep;57(3):317-21
references: 17485134
references: Lasers Surg Med. 2002;31(5):367-73
references: 12430156
references: Analyst. 2005 Jul;130(7):1070-7
references: 15965532
references: Dis Markers. 2003-2004;19(2-3):95-105
references: 15096707
references: Technol Cancer Res Treat. 2005 Oct;4(5):549-58
references: 16173825
references: Urology. 2005 Jun;65(6):1126-30
references: 15913721
references: J Biomed Opt. 2008 May-Jun;13(3):034013
references: 18601558
references: J Biomed Opt. 2009 Mar-Apr;14(2):024031
references: 19405760
references: J Biomed Opt. 2006 Nov-Dec;11(6):064027
references: 17212550
references: Curr Opin Chem Biol. 2002 Oct;6(5):651-8
references: 12413550
references: Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:6554-6
references: 19964903
references: Med Phys. 2009 Oct;36(10):4819-29
references: 19928112
references: Br J Radiol. 2007 Jul;80(955):545-56
references: 17537757
references: Skin Res Technol. 2008 Nov;14(4):484-92
references: 18937786
references: Opt Express. 2007 Jun 11;15(12):7335-50
references: 19547057
references: Gastroenterology. 2010 Jun;138(6):2140-50
references: 20420951
references: Dermatol Surg. 1995 Sep;21(9):821-2
references: 7655806
references: J Cell Biochem Suppl. 2002;39:125-37
references: 12552612
references: Indian J Urol. 2008 Oct;24(4):444-50
references: 19468494
references: Technol Cancer Res Treat. 2008 Dec;7(6):483-96
references: 19044328
references: Breast Cancer Res. 2005;7(6):279-85
references: 16457705
references: Acad Radiol. 2006 Feb;13(2):195-202
references: 16428055
references: Cancer Res. 2009 Apr 1;69(7):2919-26
references: 19293184
references: Gastrointest Endosc. 2006 Feb;63(2):257-61
references: 16427931
references: AMIA Annu Symp Proc. 2007 Oct 11;:1003
references: 18694102
references: Photochem Photobiol. 2006 Sep-Oct;82(5):1279-84
references: 16696593
references: Lasers Surg Med. 2008 Sep;40(7):461-7
references: 18727020
references: Opt Express. 2009 Feb 16;17(4):2805-17
references: 19219185
references: Pathology. 2008 Oct;40(6):600-3
references: 18752127
references: Philos Trans A Math Phys Eng Sci. 2009 Aug 13;367(1900):3055-72
references: 19581255
references: Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Nov;70(5 Pt 2):056610
references: 15600782
references: Int J Cancer. 2003 Dec 20;107(6):1047-52
references: 14601068
references: Expert Rev Med Devices. 2007 Mar;4(2):121-9
references: 17359219
references: J Biomed Opt. 2005 Sep-Oct;10(5):051503
references: 16292947
references: J Photochem Photobiol B. 2005 Jun 1;79(3):211-22
references: 15896648
references: Lasers Surg Med. 2010 Jan;42(1):15-23
references: 20077490
references: Gastrointest Endosc. 2005 Oct;62(4):521-8
references: 16185965
references: Appl Opt. 1998 Jun 1;37(16):3586-93
references: 18273328
references: Phys Med Biol. 2005 Jun 7;50(11):2573-81
references: 15901955
references: Dermatol Surg. 2007 Oct;33(10):1158-74
references: 17903149
references: J Biomed Opt. 2009 Mar-Apr;14(2):024017
references: 19405747
references: Methods Enzymol. 2003;361:452-81
references: 12624924
references: J Biomed Opt. 2005 Jul-Aug;10(4):44005
references: 16178639
references: Opt Lett. 2009 Mar 15;34(6):758-60
references: 19282923
references: Neoplasia. 2002 Jul-Aug;4(4):347-54
references: 12082551
references: Methods. 2008 Aug;45(4):289-99
references: 18539160
references: J Gastroenterol. 2008;43(4):283-90
references: 18458844
references: J Biomed Opt. 2006 Mar-Apr;11(2):024008
references: 16674198
references: J Biomed Opt. 2003 Jan;8(1):121-47
references: 12542388
references: Gynecol Oncol. 2007 Oct;107(1 Suppl 1):S138-46
references: 17908588
references: J Biomed Opt. 2007 Jan-Feb;12(1):014030
references: 17343505
references: Br J Surg. 2010 Apr;97(4):550-7
references: 20155786
references: Cancer Res. 2006 Mar 15;66(6):3317-22
references: 16540686
references: J Biomed Opt. 2009 Jan-Feb;14(1):014028
references: 19256716
references: Neoplasia. 2000 Jan-Apr;2(1-2):89-117
references: 10933071
references: Annu Int Conf IEEE Eng Med Biol Soc. 2008;2008:3107-9
references: 19163364
references: Opt Lett. 2004 Mar 15;29(6):587-9
references: 15035479
references: Opt Lett. 2009 Dec 1;34(23):3746-8
references: 19953182
references: Med Phys. 2008 Jun;35(6):2443-51
references: 18649477