title: Several stressors fail to reduce adult hippocampal neurogenesis.
abstract: Neurogenesis in the dentate gyrus of the hippocampus of adult laboratory animals has been widely reported to be vulnerable to many psychological and physical stressors. However, we have found no effects of acute restraint stress, acute or subchronic tailshock stress, or acute, subchronic, or chronic resident-intruder stress on neural progenitor cell (NPC) proliferation, short or long term survival of newborn cells, or brain-derived neurotrophic factor (BDNF) mRNA expression in adult rats. In addition, we did not observe any effect of chronic resident-intruder stress on NPC proliferation in adolescent rats. A selectively bred stress-sensitive line was also found to exhibit no alterations in NPC proliferation following tailshock stress, although this line did exhibit a lower proliferation rate under baseline (unstressed) conditions when compared with non-selected rats. These results challenge the prevailing hypothesis that any stressor of sufficient intensity and duration has a marked negative impact upon the rate of hippocampal neurogenesis, and suggest that some yet unidentified factors related to stress and experimental conditions are crucial in the regulation of neurogenesis.
authors: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, United States. nicola.hanson@gmail.com
authors: Nicola D
authors: ND
authors: Hanson
authors: Michael J
authors: MJ
authors: Owens
authors: Katherine A
authors: KA
authors: Boss-Williams
authors: Jay M
authors: JM
authors: Weiss
authors: Charles B
authors: CB
authors: Nemeroff
references: Neuroscience. 2007 Feb 23;144(4):1219-28
references: 17197100
references: Nat Neurosci. 2004 Aug;7(8):841-6
references: 15273691
references: J Neurosci. 2007 Mar 14;27(11):2734-43
references: 17360895
references: Int J Neuropsychopharmacol. 2005 Sep;8(3):357-68
references: 15769301
references: Eur J Neurosci. 2003 Feb;17(4):879-86
references: 12603278
references: Brain Res. 2004 Oct 29;1025(1-2):10-20
references: 15464739
references: J Psychiatr Res. 2010 Jan;44(2):106-11
references: 19573876
references: J Pain. 2006 Aug;7(8):544-55
references: 16885011
references: Biol Psychiatry. 2002 Dec 1;52(11):1057-65
references: 12460689
references: Dev Neurosci. 2007;29(1-2):124-33
references: 17148955
references: Biol Psychiatry. 2007 Sep 1;62(5):487-95
references: 17306770
references: J Neurosci Res. 2006 Nov 1;84(6):1292-302
references: 17099915
references: Brain Res Bull. 2004 Dec 15;64(4):303-8
references: 15561464
references: Biochem Pharmacol. 2008 Jan 1;75(1):134-59
references: 18053966
references: Neuropsychopharmacology. 2003 Sep;28(9):1562-71
references: 12838272
references: Neurosci Res. 2005 Oct;53(2):129-39
references: 16024125
references: Hippocampus. 2003;13(5):646-55
references: 12921353
references: Neuroreport. 2006 Jun 26;17(9):863-7
references: 16738477
references: Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):751-6
references: 18178625
references: Biol Psychiatry. 2003 Nov 15;54(10):1035-40
references: 14625145
references: Hippocampus. 2010 May;20(5):596-607
references: 19554644
references: Biol Psychiatry. 1986 Jul;21(8-9):724-34
references: 3730457
references: Neuroreport. 2006 Apr 24;17(6):593-7
references: 16603918
references: Trends Neurosci. 2005 Apr;28(4):171-2
references: 15808349
references: Biol Psychiatry. 2006 Jun 15;59(12):1116-27
references: 16631126
references: Neuroscience. 2005;130(1):17-24
references: 15561421
references: Neurochem Res. 1980 Jan;5(1):9-22
references: 7366796
references: Neuroscience. 2008 Dec 2;157(3):677-82
references: 18930787
references: J Comp Neurol. 1975 Jan 15;159(2):149-75
references: 1112911
references: J Pharmacol Exp Ther. 2011 Apr;337(1):180-6
references: 21220416
references: J Neurosci. 1996 Mar 15;16(6):2027-33
references: 8604047
references: Neuroscience. 2006;137(2):437-45
references: 16289890
references: Behav Brain Res. 2006 Sep 25;172(2):344-50
references: 16839619