title: Effects of tnp-470 (agm-1470) on tumor-growth, angiogenesis and serum copper levels in liver-cancer bearing rats.
abstract: Administration of TNP-470 (AGM-1470), a newly developed angiogenesis inhibitor, elevated serum copper concentrations (SCu) in a dose-dependent manner in normal rats as well as tumor-bearing rats. After discontinuation of TNP-470, SCu returned to the normal range in normal rats. In tumor-bearing rats, however, SCu decreased and then became elevated in relation to the tumor growth and capillary density in this hepatic tumor. The mechanisms leading to serum copper elevation may reflect a specific pharmacologic action of TNP-470, though it may also be related to tumor growth and reactivation of tumor angiogenesis after cessation of TNP-470.
authors: S
authors: S
authors: Matsuoka
authors: J
authors: J
authors: Uchino
authors: Y
authors: Y
authors: Une
authors: H
authors: H
authors: Ishimura
authors: S
authors: S
authors: Tsuchimoto
authors: T
authors: T
authors: Kamiyama