title: Prevalence, predictors and prognostic significance of microalbuminuria in acute cardiac patients: a single center experience.
abstract: The objective of this study was to prospectively assess the prevalence, predictors and prognostic significance of microalbuminuria in a large cohort of consecutive acute cardiac patients, admitted to an intensive cardiac care unit from 1 January 2008 to 30 June 2009. In 815 acute cardiac patients, microalbuminuria is detectable in 39.3%. Microalbuminuria shows a significant negative correlation with left ventricular ejection fraction (Spearman's ρ = -0.228; p < 0.001), while it is positively correlated with C-reactive protein (Spearman's ρ = 0.239; p < 0.001), NT-pro-BNP (Spearman's ρ = 0.306; p < 0.001) and glycemia (Spearman's ρ = 0.191; p < 0.001). Microalbuminuria is an independent predictor for in-hospital mortality (1 μg/min step) (OR 1.015; 95% CI 1.008-1.023; p < 0.001). In the acute phase of cardiac patients, microalbuminuria is a common finding, and it represents an independent predictor for early mortality. It is strictly linked to the inflammatory activation (as indicated by C-reactive protein) and to acute glucose values, thus suggesting that it may be part of the acute response to stress.
authors: Intensive Cardiac Care Unit, Heart and Vessel Department, Azienda Ospedaliero Universitaria Careggi, VialeMorgagni 85, 50134, Florence, Italy. seravalente@hotmail.com
authors: Serafina
authors: S
authors: Valente
authors: Chiara
authors: C
authors: Lazzeri
authors: Marco
authors: M
authors: Chiostri
authors: Bruno
authors: B
authors: Alterini
authors: Agostino
authors: A
authors: Ognibene
authors: Cristina
authors: C
authors: Giglioli
authors: Clara
authors: C
authors: Pigozzi
authors: Gian Franco
authors: GF
authors: Gensini
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