title: Compliant gluten-free children with celiac disease: an evaluation of psychological distress.
abstract: BACKGROUND
  Children with chronic illnesses are known to have increased risks for emotional and behavioral problems. In the present study, children and adolescent suffering from celiac disease (CD) were compared with healthy controls to assess differences in the psychological profile.
  
  
  METHODS
  A total of 100 well-treated and compliant CD patients (65 females/35 males; age mean ± SD: 10.38 ± 2.71) were compared to 100 normal controls (58 females/42 males; age mean ± SD: 11.47 ± 2.61). Emotional and behavioral problems were assessed by the Child Behavior Checklist (CBCL), the Children's Depression Inventory (CDI) and the Multidimensional Anxiety Scale for Children (MASC).
  
  
  RESULTS
  Subjects with CD self-reported an increased rate of anxiety and depression symptoms and showed higher scores in "harm avoidance" and "somatic complaints", in the CBCL parent-report questionnaire, as compared to healthy control subjects. Furthermore, gender differences could be observed in the group of CD patients, with males displaying significantly higher CBCL externalizing scores, in social, thought and attention problems, as compared to female, who in turns showed more prominent internalizing symptoms such as depression.
  
  
  CONCLUSIONS
  The increased rate of emotional and behavioral problems in children and adolescent with CD emphasizes the importance of an early detection of mental health problems in these children.
authors: Department of Paediatrics, Division of Child Neurology and Psychiatry, University of Catania, Catania, Italy. gigimazzone@yahoo.it
authors: Luigi
authors: L
authors: Mazzone
authors: Laura
authors: L
authors: Reale
authors: Massimo
authors: M
authors: Spina
authors: Manuela
authors: M
authors: Guarnera
authors: Elena
authors: E
authors: Lionetti
authors: Serena
authors: S
authors: Martorana
authors: Domenico
authors: D
authors: Mazzone
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