title: The vascular effects of infection in Pediatric Stroke (VIPS) Study.
abstract: Understanding the vascular injury pathway is crucial to developing rational strategies for secondary stroke prevention in children. The multicenter Vascular Effects of Infection in Pediatric Stroke (VIPS) cohort study will test the hypotheses that (1) infection can lead to childhood arterial ischemic stroke by causing vascular injury and (2) resultant arteriopathy and inflammatory markers predict recurrent stroke. The authors are prospectively enrolling 480 children (aged 1 month through 18 years) with arterial ischemic stroke and collecting extensive infectious histories, blood and serum samples (and cerebrospinal fluid, when clinically obtained), and standardized brain and cerebrovascular imaging studies. Laboratory assays include serologies (acute and convalescent) and molecular assays for herpesviruses and levels of inflammatory markers. Participants are followed prospectively for recurrent ischemic events (minimum of 1 year). The analyses will measure association between markers of infection and cerebral arteriopathy and will assess whether cerebral arteriopathy and inflammatory markers predict recurrent stroke.
authors: Department of Neurology, University of California San Francisco, San Francisco, California, 94143-0114, USA.
authors: Heather J
authors: HJ
authors: Fullerton
authors: Mitchell S V
authors: MS
authors: Elkind
authors: A James
authors: AJ
authors: Barkovich
authors: Carol
authors: C
authors: Glaser
authors: David
authors: D
authors: Glidden
authors: Nancy K
authors: NK
authors: Hills
authors: Carlos
authors: C
authors: Leiva-Salinas
authors: Max
authors: M
authors: Wintermark
authors: Gabrielle A
authors: GA
authors: Deveber
references: N Engl J Med. 1999 Feb 11;340(6):448-54
references: 9971870
references: J Clin Epidemiol. 1995 Nov;48(11):1343-8
references: 7490597
references: Circulation. 2000 May 9;101(18):2149-53
references: 10801754
references: Arch Neurol. 1999 Jul;56(7):851-6
references: 10404987
references: Pediatr Infect Dis J. 2000 Jul;19(7):648-53
references: 10917224
references: Cleve Clin J Med. 1992 May-Jun;59(3):293-306
references: 1516217
references: Arthritis Rheum. 2002 Dec 15;47(6):662-9
references: 12522842
references: Ann Neurol. 1985 Sep;18(3):358-60
references: 4051463
references: Acta Neurol Scand. 2007 Jan;115(1):60-6
references: 17156267
references: Clin Neurol Neurosurg. 1997 Oct;99 Suppl 2:S238-40
references: 9409446
references: Neurology. 2006 Dec 12;67(11):2045-7
references: 17159117
references: J Am Coll Cardiol. 2007 May 22;49(20):1993-2000
references: 17512353
references: Stroke. 2009 Nov;40(11):3415-21
references: 19762687
references: Ann Neurol. 1999 May;45(5):679-80
references: 10319896
references: Neuropediatrics. 1994 Oct;25(5):227-33
references: 7885530
references: N Engl J Med. 1997 Apr 3;336(14):973-9
references: 9077376
references: J Child Neurol. 1998 Jan;13(1):27-32
references: 9477245
references: Neuropediatrics. 1998 Aug;29(4):202-7
references: 9762696
references: J Magn Reson Imaging. 1999 Mar;9(3):491-6
references: 10194723
references: Arch Dis Child. 1997 Jun;76(6):522-5
references: 9245851
references: Circulation. 1998 Sep 1;98(9):839-44
references: 9738637
references: Br Med J (Clin Res Ed). 1988 Apr 23;296(6630):1156-60
references: 3132245
references: Eur Heart J. 2008 May;29(9):1096-102
references: 18339606
references: Arthritis Rheum. 2006 Apr;54(4):1291-7
references: 16575852
references: Circulation. 1995 May 1;91(9):2488-96
references: 7729036
references: Stroke. 2001 Jun;32(6):1257-62
references: 11387484
references: Circulation. 2000 Apr 18;101(15):1767-72
references: 10769275
references: Stroke. 2001 Nov;32(11):2575-9
references: 11692019
references: Stroke. 1986 Sep-Oct;17(5):1024-8
references: 3020742
references: AJNR Am J Neuroradiol. 2006 Apr;27(4):884-6
references: 16611784
references: Stroke. 2003 Oct;34(10):2463-8
references: 14500938
references: Pediatrics. 2007 Mar;119(3):495-501
references: 17332202
references: Arch Intern Med. 2006 Oct 23;166(19):2073-80
references: 17060536
references: Eur Heart J. 2008 Jan;29(2):224-30
references: 18156137
references: Ann Neurol. 1986 Jan;19(1):7-14
references: 3004319
references: J Am Coll Cardiol. 2007 Jul 10;50(2):159-65
references: 17616301
references: Pediatr Neurol. 2000 Oct;23(4):345-8
references: 11068169
references: Pediatr Infect Dis J. 2000 Jul;19(7):653-6
references: 10917225
references: J Child Neurol. 1993 Jul;8(3):250-5
references: 8409267
references: Arch Intern Med. 2005 Nov 28;165(21):2479-84
references: 16314544
references: Eur J Paediatr Neurol. 2002;6(6):331-3
references: 12401459
references: Circulation. 2006 Nov 14;114(20):2170-7
references: 17075014
references: Arterioscler Thromb Vasc Biol. 2000 Apr;20(4):1052-6
references: 10764672
references: Arch Neurol. 1980 Apr;37(4):239-40
references: 6244805
references: Circulation. 2009 Mar 17;119(10):1417-23
references: 19255344
references: Circulation. 2005 Feb 8;111(5):570-5
references: 15699277
references: J Child Neurol. 2009 Oct;24(10):1250-7
references: 19351813
references: Int J Infect Dis. 2003 Dec;7(4):274-7
references: 14656418
references: Neurology. 2001 Oct 9;57(7):1155-60
references: 11601431
references: J Child Neurol. 1993 Jul;8(3):201-20
references: 8409261
references: Atherosclerosis. 2003 Apr;167(2):223-30
references: 12818404
references: Curr Opin Pediatr. 2004 Dec;16(6):617-22
references: 15548922
references: Semin Neurol. 2006 Feb;26(1):88-99
references: 16479447
references: J Child Neurol. 2000 May;15(5):316-24
references: 10830198
references: Stroke. 2003 Jul;34(7):e79-81
references: 12805497
references: Curr Opin Neurol. 2002 Apr;15(2):139-44
references: 11923626
references: AJNR Am J Neuroradiol. 1995 Mar;16(3):449-52
references: 7793362
references: Ann Neurol. 2003 Feb;53(2):167-73
references: 12557282
references: Neurology. 2009 Feb 17;72(7):627-34
references: 19221296
references: N Engl J Med. 2003 Oct 23;349(17):1595-604
references: 14573731
references: JAMA. 2001 Nov 7;286(17):2136-42
references: 11694155
references: Neurology. 1978 Aug;28(8):763-8
references: 567292
references: Arch Neurol. 1990 Sep;47(9):1033-5
references: 2168697
references: Arterioscler Thromb Vasc Biol. 2000 Apr;20(4):1047-51
references: 10764671
references: Ann Neurol. 2006 Apr;59(4):620-6
references: 16450385
references: Circulation. 2003 Apr 22;107(15):2016-20
references: 12681999
references: Eur J Paediatr Neurol. 2003;7(2):73-5
references: 12697430
references: J Child Neurol. 2000 May;15(5):299-307
references: 10830196
references: Stroke. 1995 Mar;26(3):373-9
references: 7886709
references: Circulation. 1998 May 26;97(20):2007-11
references: 9610529
references: Neurology. 2005 Feb 22;64(4):660-3
references: 15728288
references: N Engl J Med. 2000 Mar 23;342(12):836-43
references: 10733371
references: Lancet. 2002 Nov 16;360(9345):1540-5
references: 12443591
references: Neurology. 1996 Aug;47(2):569-70
references: 8757040
references: Pediatr Neurol. 2001 May;24(5):387-9
references: 11516617