title: Potassium clavulanate.
abstract: The title salt, K(+)·C(8)H(8)NO(5) (-) [systematic name: potassium (2R,5R,Z)-3-(2-hy-droxy-ethyl-idene)-7-oxo-4-oxa-1-aza-bicyclo-[3.2.0]heptane-2-carb-oxyl-ate], a widely used β-lactam anti-biotic, is usually chemically unstable even in the solid state owing to its tendency to be hydrolysed. In the crystal structure, the potassium cations are arranged along the a axis, forming inter-actions to the carboxyl-ate and hy-droxy groups, resulting in one-dimensional ionic columns. These columns are arranged along the b axis, connected by O-H⋯O hydrogen bonds, forming a layer in the ab plane.
authors: Kotaro
authors: K
authors: Fujii
authors: Kazuyuki
authors: K
authors: Toyota
authors: Akiko
authors: A
authors: Sekine
authors: Hidehiro
authors: H
authors: Uekusa
authors: Ilma
authors: I
authors: Nugrahani
authors: Sukmadjaja
authors: S
authors: Asyarie
authors: N Sundani
authors: NS
authors: Soewandhi
authors: Slamet
authors: S
authors: Ibrahim
references: Biotechnol Bioeng. 2008 Jun 15;100(3):439-47
references: 18183630
references: Biotechnol Adv. 2008 Jul-Aug;26(4):335-51
references: 18450406
references: Appl Microbiol Biotechnol. 1996 Mar;45(1-2):41-6
references: 8920178
references: Chem Pharm Bull (Tokyo). 1985 Jun;33(6):2461-8
references: 2998632
references: J Pharm Sci. 2007 May;96(5):1090-9
references: 17455335
references: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references: 18156677
references: Clin Pharmacokinet. 2005;44(11):1097-115
references: 16231964