title: [Cytopenias following kidney transplantation].
abstract: Cytopenias frequently occur during the first months after solid organ transplantation. Many mechanisms are involved but drugs toxicity and infections are the major causes of cytopenias. Anemia is also related with chronic kidney graft dysfunction. Several drugs are pointed out but antithymocyte globulin, antiproliferative drugs and antiviral drugs are mainly responsible for cytopenias. Infectious causes are mainly viral and can rarely induce macrophage activation syndromes. Passenger lymphocyte syndrome is only described after ABO incompatible transplantations. Thrombotic microangiopathies are frequent and multifactorial (antibody mediated rejection, calcineurine inhibitors toxicity, infections, initial nephropathy recurrence). Cytopenias following transplantation increase the risk of infectious disease by neutropenia and generally lead to an immunosuppressive therapy reduction. It seems to increase the risk of rejection when the baseline immunosuppressive level is not further restored.
authors: Service de néphrologie et transplantation, hôpital Saint-Louis, université Denis-Diderot Paris 7, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France. denis.viglietti@wanadoo.fr
authors: Denis
authors: D
authors: Viglietti
authors: Marie-Noëlle
authors: MN
authors: Peraldi