title: In vitro inhibition of polyphenol oxidase by some new diarylureas.
abstract: A new series of N,N'-diarylureas (1-9) was synthesized. These compounds were investigated as inhibitors of polyphenol oxidase (PPO) which had been purified from banana by an affinity gel comprised of Sepharose 4B-l-tyrosine-p-amino benzoic acid. K(i) values for (1), (2), (3), (5), (6), (7) and (8) were determined as 0.285, 17.97, 0.187, 0.108, 0.063, 0.044 and 0.047 mM, respectively. Thus (2) was by far the most effective inhibitor. Interestingly, (4) and (9) behaved as an activator of PPO in this study.
authors: Department of Chemistry, Balikesir University, Balikesir, Turkey.
authors: Dudu
authors: D
authors: Demir
authors: Nahit
authors: N
authors: Gençer
authors: Oktay
authors: O
authors: Arslan
authors: Hayriye
authors: H
authors: Genç
authors: Mustafa
authors: M
authors: Zengin