title: Management of Bladder Cancer following Solid Organ Transplantation.
abstract: Objective. Present our experience managing bladder cancer following liver and renal transplantation. Methods. Single institution retrospective review of patients diagnosed with bladder urothelial carcinoma (BUC) following solid organ transplantation between January 1992 and December 2007. Results. Of the 2,925 renal and 2,761 liver transplant recipients reviewed, we identified eleven patients (0.2%) following transplant diagnosed with BUC. Two patients with low grade T1 TCC were managed by TURBT. Three patients with CIS and one patient with T1 low grade BUC were treated by TURBT and adjuvant BCG. All four are alive and free of recurrence at a mean follow-up of 51 ± 22 months. One patient with T1 high grade BUC underwent radical cystectomy and remains disease free with a follow-up of 98 months. Muscle invasive TCC was diagnosed in four patients at a median of 3.6 years following transplantation. Two patients are recurrence free at 24 and 36 months following radical cystectomy. Urinary diversion and palliative XRT were performed in one patient with un-resectable disease. Conclusions. Bladder cancer is uncommon following renal and liver transplantation, but it can be managed successfully with local and/or extirpative therapy. The use of intravesical BCG is possible in select immunosuppressed patients.
authors: Department of Urology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors: Jeffrey J
authors: JJ
authors: Tomaszewski
authors: Jeffrey A
authors: JA
authors: Larson
authors: Marc C
authors: MC
authors: Smaldone
authors: Matthew H
authors: MH
authors: Hayn
authors: Stephen V
authors: SV
authors: Jackman
references: Urology. 1997 Oct;50(4):525-8
references: 9338726
references: Clin Transplant. 1998 Feb;12(1):65-9
references: 9541425
references: J Clin Oncol. 2001 Feb 1;19(3):666-75
references: 11157016
references: Cancer. 1992 Apr 1;69(7):1776-90
references: 1551063
references: Urol Int. 2003;71(2):176-7
references: 12890956
references: Lancet. 2000 May 27;355(9218):1886-7
references: 10866449
references: J Urol. 1998 May;159(5):1635-6
references: 9554370
references: J Urol. 2009 Oct;182(4):1482-7
references: 19683766
references: Ann Transplant. 1997;2(4):14-7
references: 9869873
references: Cancer Res. 1991 Jan 15;51(2):629-31
references: 1985779
references: Prog Urol. 2008 Dec;18(13):1097-9
references: 19041819
references: J Urol. 1988 Nov;140(5):1009-11
references: 3050150
references: Br J Urol. 1993 Oct;72(4):511-3
references: 8261312
references: BJU Int. 2008 Jan;101(1):30-5
references: 17850360
references: Urology. 2005 Dec;66(6 Suppl 1):4-34
references: 16399414
references: J Urol. 1990 Dec;144(6):1331-3; discussion 1333-4
references: 2231918
references: J Urol. 2005 Mar;173(3):881-4
references: 15711303
references: Clin Transpl. 1998;:147-58
references: 10503093
references: J Urol. 2004 Mar;171(3):1085-8
references: 14767276
references: Transplant Proc. 1999 Feb-Mar;31(1-2):1260-2
references: 10083562
references: Transplantation. 2005 Sep 27;80(6):709-16
references: 16210955
references: Cancer. 1996 Jan 1;77(1):160-3
references: 8630924
references: Ann Surg. 2001 Aug;234(2):149-64
references: 11505060
references: BJU Int. 2007 Sep;100(3):502-5
references: 17669141
references: World J Surg. 2003 Aug;27(8):912-6
references: 12784144
references: Transplantation. 2003 Nov 27;76(10):1514-6
references: 14657696
references: Nephrol Dial Transplant. 2000 Jan;15(1):110-2
references: 10607779
references: Actas Urol Esp. 2010 Jan;34(1):51-62
references: 20223133
references: Br J Urol. 1995 May;75(5):572-7
references: 7613790
references: J Urol. 1990 Nov;144(5):1233-5
references: 2231905
references: Hematol Oncol Clin North Am. 1993 Apr;7(2):431-45
references: 8468275
references: Urology. 2004 Apr;63(4):682-6; discussion 686-7
references: 15072879
references: Urology. 2011 Feb;77(2):514
references: 21295262
references: Clin Transplant. 2002 Dec;16(6):410-3
references: 12437619
references: Transplantation. 2009 May 15;87(9):1347-59
references: 19424035
references: J Urol. 1997 Dec;158(6):2236-7
references: 9366357
references: J Urol. 1995 Jul;154(1):57-61
references: 7776456
references: Int J Cancer. 1995 Jan 17;60(2):183-9
references: 7829213
references: J Urol. 2001 Oct;166(4):1383
references: 11547081