title: Generation and identification of rat fetal cerebral radial glia-like cells in vitro.
abstract: The role of radial glia cells (RGCs) as neural progenitors and as guides for migrating neurons is well established, mouse or human-derived radial glia (RG)-like cells in vitro showed some astroglia and stem/progenitor properties like RGCs in vivo, but different species-derived RG-like cells present some different properties. Here we acquired rat-derived RG-like cells on adherent conditions in vitro and then identified their astroglia and stem/progenitor properties. Similarly to the RGCs, the RG-like cells could be double-labeled by brain lipid-binding protein, glial fibrillary acidic protein, vimentin with nestin and expressed some astroglia and stem/progenitor genes; these cells also presented tripotent differentiation potentialities, albeit the ability of gliogenesis far exceeded the neurogenesis in vitro. Taken together, we acquired and identified some properties of rat-derived RG-like cells from fetal cerebral cortices in vitro.
authors: Department of Anatomy and Neurobiology, the Jiangsu Key Laboratory of Neuroregeneration, Nantong University, No. 19 Qixiu Road, Nantong, China.
authors: Haoming
authors: H
authors: Li
authors: Guohua
authors: G
authors: Jin
authors: Jianbing
authors: J
authors: Qin
authors: Meiling
authors: M
authors: Tian
authors: Xuefeng
authors: X
authors: Tan
authors: Xinhua
authors: X
authors: Zhang
authors: Weiwei
authors: W
authors: Yang
authors: Jinhong
authors: J
authors: Shi
authors: Linqing
authors: L
authors: Zou
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