title: Antitumor effect of trimelamol against human breast carcinoma xenografts in nude mice.
abstract: The antitumor effect of N-2, N-4, N-6-trihydroxymethyl-N-2, N-4, N-6-trimethylmelamine (trimelamol), a synthetic analogue of hexamethylmelamine, was investigated using human breast carcinoma xenografts in nude mice. Four tumor models, T-61, Br-10, R-27 and MCF-7 were estrogen receptor (ER)-positive and their growth was estradiol-dependent. The MX-1 model was ER-negative and grew estradiol-independently. Sixty mg of trimelamol per kg dissolved in 5% dimethylsulphoxide (DMSO) with 5% glucose was administered intraperitoneally for 5 days weekly for three weeks. Trimelamol showed potent antitumor activity on T-61 and MX-1 in a dose-responsive manner with a marginal effect on Br-10, whilst R-27 and MCF-7 were insensitive to this agent. This antitumor spectrum on human breast carcinoma xenografts was similar to that of hexamethylmelamine previously reported using the same xenograft models. Trimelamol is water-soluble and does not require metabolic activation which is needed for hexamethylmelamine. These advantages allow the paraenteral administration of trimelamol, and warrant the further investigation of this drug for breast carcinomas.
authors: SOCIAL INSURANCE SAITAMACHUO HOSP,DEPT SURG,URAWA,SAITAMA 336,JAPAN. KEIO UNIV,SCH MED,DEPT SURG,SHINJUKU KU,TOKYO 160,JAPAN. KITASATO INST HOSP,DEPT SURG,MINATO KU,TOKYO 108,JAPAN. INST CANC RES,CRC,CTR CANC THERAPEUT,SUTTON SM2 5NG,SURREY,ENGLAND.
authors: Y
authors: Y
authors: Yamada
authors: T
authors: T
authors: Kubota
authors: Y
authors: Y
authors: Hoshiya
authors: F
authors: F
authors: Asanuma
authors: J
authors: J
authors: Koh
authors: M
authors: M
authors: Kitajima
authors: H
authors: H
authors: Coley
authors: I
authors: I
authors: Judson