title: Tango between ubiquitin ligase and deubiquitinase keeps cyclin A tag free.
abstract: Ubiquitin ligases (E3s) and ubiquitin-specific proteases (USPs) dynamically oppose each other during ubiquitination. In this issue of Molecular Cell, Huang et al. (2011) provide a counterintuitive example of a USP residing in an E3 complex, and establish Usp37 as a gatekeeper of APC/C-mediated ubiquitination of cyclin A.
authors: Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. hongtao.yu@utsouthwestern.edu
authors: Hongtao
authors: H
authors: Yu
references: Science. 2006 Aug 4;313(5787):680-4
references: 16825537
references: Nature. 2011 Feb 10;470(7333):274-8
references: 21107322
references: Nat Struct Mol Biol. 2011 Jan;18(1):6-13
references: 21186364
references: Mol Cell. 2007 Jul 6;27(1):3-16
references: 17612486
references: Mol Cell. 2011 May 20;42(4):511-23
references: 21596315
references: Nat Rev Mol Cell Biol. 2006 Sep;7(9):644-56
references: 16896351
references: J Biol Chem. 2007 Feb 9;282(6):3672-9
references: 17158872