title: Emergence of oseltamivir-resistant pandemic H1N1 in an immunocompetent child with severe status asthmaticus.
abstract: BACKGROUND
  Pandemic influenza A (H1N1) may cause severe illness in pediatric patient with chronic lung disease.
  
  
  METHODS
  We describe the emergence of oseltamivir resistance in an immunocompetent child with status asthmaticus triggered by pandemic influenza A (H1N1). This case highlights the possible relationship between influenza viral load and risk of resistance emergence in children with asthma. Influenza vaccination should continue to be emphasized as the mainstay of prevention in children with chronic lung disease.
  
  
  CONCLUSIONS
  Influenza virus can lead to severe status asthmaticus and can develop oseltamivir resistance in immunocompetent children.
authors: Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. crenaud@fhcrc.org
authors: Christian
authors: C
authors: Renaud
authors: Jane
authors: J
authors: Kuypers
authors: François
authors: F
authors: Aspesberro
authors: Margaret
authors: M
authors: Rosenfeld
authors: Janet A
authors: JA
authors: Englund