title: Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts.
abstract: BACKGROUND
  Both genome-wide association studies and candidate gene studies have reported that the major determinant of plasma levels of the Lipoprotein (a) [Lp(a)] reside within the LPA locus on chromosome 6. We have used data from the HumanCVD BeadChip to explore the contribution of other candidate genes determining Lp(a) levels.
  
  
  METHODS
  48,032 single nucleotide polymorphisms (SNPs) from the Illumina HumanCVD BeadChip were genotyped in 5059 participants of the Whitehall II study (WHII) of randomly ascertained healthy men and women. SNPs showing association with Lp(a) levels of p<10(-4) outside the LPA locus were selected for replication in a total of an additional 9463 participants of five European based studies (EAS, EPIC-Norfolk, NPHSII, PROCARDIS, and SAPHIR).
  
  
  RESULTS
  In Whitehall II, apart from the LPA locus (where p values for several SNPs were <10(-30)) there was significant association at four loci GALNT2, FABP1, PPARGC1A and TNFRSFF11A. However, a meta-analysis of the six studies did not confirm any of these findings.
  
  
  CONCLUSIONS
  Results from this meta analysis of 14,522 participants revealed no candidate genes from the HumanCVD BeadChip outside the LPA locus to have an effect on Lp(a) levels. Further studies with genome-wide and denser SNP coverage are required to confirm or refute this finding.
authors: University College London Genetics Institute, Department of Genetics, Environment and Evolution, Gower St, London WC1E 6BT, UK.
authors: Delilah
authors: D
authors: Zabaneh
authors: Meena
authors: M
authors: Kumari
authors: Manj
authors: M
authors: Sandhu
authors: Nick
authors: N
authors: Wareham
authors: Nick
authors: N
authors: Wainwright
authors: Theodore
authors: T
authors: Papamarkou
authors: Jemma
authors: J
authors: Hopewell
authors: Robert
authors: R
authors: Clarke
authors: KaWah
authors: K
authors: Li
authors: Jutta
authors: J
authors: Palmen
authors: Philippa J
authors: PJ
authors: Talmud
authors: Florian
authors: F
authors: Kronenberg
authors: Claudia
authors: C
authors: Lamina
authors: Monika
authors: M
authors: Summerer
authors: Bernhard
authors: B
authors: Paulweber
authors: Jackie
authors: J
authors: Price
authors: Gerry
authors: G
authors: Fowkes
authors: Marlene
authors: M
authors: Stewart
authors: Fotios
authors: F
authors: Drenos
authors: Sonia
authors: S
authors: Shah
authors: Tina
authors: T
authors: Shah
authors: Juan-Pablo
authors: JP
authors: Casas
authors: Mika
authors: M
authors: Kivimaki
authors: John
authors: J
authors: Whittaker
authors: Aroon D
authors: AD
authors: Hingorani
authors: Steve E
authors: SE
authors: Humphries
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