title: Mechanisms of resistance to RAF inhibitors in melanoma.
abstract: The recent RAF inhibitor trial with PLX4032/RG7204 in late-stage mutant B-RAF melanoma patients has been lauded as a success story for personalized cancer therapy since short-term clinical responses were observed in the majority of patients. However, initial responses were followed by subsequent tumor re-growth, and a subset of patients showed intrinsic resistance. Bi-directional translational efforts are now essential to determine the mechanisms underlying acquired/secondary and intrinsic resistance to RAF inhibitors.
authors: Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Andrew.Aplin@KimmelCancerCenter.Org
authors: Andrew E
authors: AE
authors: Aplin
authors: Fred M
authors: FM
authors: Kaplan
authors: Yongping
authors: Y
authors: Shao
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