title: [Urinary level of tissue factor and its procoagulant activity in patients with type 2 diabetes].
abstract: OBJECTIVE
  To examine the urinary level of tissue factor (uTF) and its procoagulant activity (PCA) in patients with diabetes mellitus, and explore the relationship between uTF and renal damage in diabetes mellitus.
  
  
  METHODS
  Eighty-six patients with type 2 diabetes mellitus were divided into 3 groups according to urine albumin excretion (UACR), namely normal albuminuria group, microalbuminuria group and macroalbuminuria group. The levels of uTF, PCA, blood urea nitrogen (BUN), serum creatinine (CRE), serum cystatin C (CYSC), glycohemoglobin A1c (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) were measured in all the patients and 21 healthy controls.
  
  
  RESULTS
  Compared with normal control, the diabetic patients showed significantly increased levels of uTF and PCA. The urinary TF-PCA was positively correlated to BUN, CYSC, CRE, UACR, fasting glucose and hs-CRP, but not to uTF; only hs-CRP, UACR were positively correlated to uTF.
  
  
  CONCLUSIONS
  uTF is probably implicated in the development and progression of diabetic nephropathy.
authors: Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. dffwj@sina.com
authors: Wen-jin
authors: WJ
authors: Fu
authors: Lei
authors: L
authors: Zheng
authors: Qian
authors: Q
authors: Wang
authors: Ren-tang
authors: RT
authors: Deng
authors: Chang-qin
authors: CQ
authors: Ye
authors: Shao-bo
authors: SB
authors: Wang
authors: Lan-fen
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authors: Peng
authors: Shi-long
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authors: Xiong
authors: Hui-hua
authors: HH
authors: Tang