title: Single-channel recording from adult Brugia malayi.
abstract: Lymphatic filariasis is a significant cause of morbidity in humans. One of the causative agents is Brugia malayi a clade III nematode. Current therapeutic agents are effective against the microfilaria but less so against the adults residing in the host lymphatics. A large number of anthelmintics act on nematode ion channels including the nicotinic receptors found on nematode somatic muscle. The purpose of this study was to develop a preparation from adult B. malayi that was amenable to patch-clamp recording to facilitate the study of the ion channels present in this organism. We also present a preliminary characterization of the single-channel properties of nicotinic receptors from the adult musculature.
authors: Dept. Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, USA. alanr@iastate.edu
authors: Alan P
authors: AP
authors: Robertson
authors: Sreekanth
authors: S
authors: Puttachary
authors: Richard J
authors: RJ
authors: Martin
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