title: Brief review of the role of glycogen synthase kinase-3β in amyotrophic lateral sclerosis.
abstract: Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenic mechanisms in motor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy.
authors: Department of Neurology, College of Medicine Hanyang University, no. 17 Haengdang-Dong, Seongdong-Gu, Seoul 133-792, Republic of Korea.
authors: Seong-Ho
authors: SH
authors: Koh
authors: Wonki
authors: W
authors: Baek
authors: Seung H
authors: SH
authors: Kim
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