title: MRI findings of recurrent hepatocellular carcinoma after liver transplantation: preliminary results.
abstract: OBJECTIVE
  To describe the patterns of recurrence and serial magnetic resonance imaging (MRI) features of hepatocellular carcinoma (HCC) after liver transplantation.
  
  
  METHODS
  All cases of recurrent HCC after transplantation between September 2002 and August 2009 that underwent MRI including precontrast T1, T2-weighted images, and postgadolinium dynamic images were reviewed. On MRI we evaluated the characteristics and patterns of recurrent HCC after transplantation.
  
  
  RESULTS
  A total 7 of 76 transplanted patients (four men, three women, age range, 45-63, mean 52.7 years) were included in this study. Four patients (57.1%) were identified to have a pattern of persistent local disease (PLD) near the transplanted liver, hepatorenal space, or suture site within 2.75 years (range, 2-4 years). Two patients showed recurrent HCC in the allograft alone within 5 years. One patient showed an intraperitoneal seeding (IPS) pattern which demonstrated diffuse peritoneal infiltration and thickening within 9 months. The diffuse metastatic disease (DMD) pattern was observed as a late manifestation of PLD and IPS. The most prominent volume of recurrent tumor burden was found in an extrahepatic (5 of 7 patients) compared to an intrahepatic (2 of 7 patients) location. The signal intensities and enhancement patterns did not exhibit change with disease progression.
  
  
  CONCLUSIONS
  We describe four patterns of recurrence of HCC following transplant. The most prominent tumor burden was located in an extrahepatic compared to an intrahepatic location.
authors: Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7510, USA.
authors: Chang Hee
authors: CH
authors: Lee
authors: Lauren M
authors: LM
authors: Brubaker
authors: David A
authors: DA
authors: Gerber
authors: Young Mi
authors: YM
authors: Ku
authors: Young Hoon
authors: YH
authors: Kim
authors: Sang Soo
authors: SS
authors: Shin
authors: Richard C
authors: RC
authors: Semelka