title: Efficacy of temsirolimus after previous treatment with sunitinib, sorafenib or everolimus in advanced renal cell cancer.
abstract: OBJECTIVE
  Temsirolimus inhibits the mammalian target of rapamycin with demonstrated efficacy in patients with advanced renal cell cancer.
  
  
  METHODS
  We present a retrospective analysis of our single-center experience with temsirolimus in patients pretreated with sunitinib, sorafenib or everolimus. Sixteen patients were treated within our center starting in December 2006 until September 2009. The majority of patients (14 of 16) had received a prior antiangiogenic pretreatment. We further analyzed the efficacy of subsequent treatment with temsirolimus in these patients.
  
  
  RESULTS
  Stable disease could be achieved in 8 of 14 pretreated patients (57%). The duration of median progression-free survival was 10 weeks (range 1-43). Especially patients with a good response to previous antiangiogenic treatment, a good overall condition and a low Memorial Sloan Kettering Cancer Center (MSKCC) score benefited from subsequent treatment with temsirolimus. We did not see any complete or partial response meeting the World Health Organization criteria. Temsirolimus was well tolerated.
  
  
  CONCLUSIONS
  Temsirolimus appears to be an effective and well-tolerated substance in the treatment of patients with a good performance status, low MSKCC score and stable disease under previous antiangiogenic treatment in advanced renal cell cancer. However, its use is highly questionable in pretreated patients with a poor performance score and a high MSKCC score.
authors: 3rd Medical Department of Hematology, Medical Oncology, Hemostaseology, Rheumatology and Infectious Disease, Laboratory for Immunological and Molecular Cancer Research, University Hospital Salzburg, Salzburg, Austria.
authors: Michael
authors: M
authors: Grundbichler
authors: Brigitte
authors: B
authors: Mlineritsch
authors: Sigrun
authors: S
authors: Ressler
authors: Martin
authors: M
authors: Moik
authors: Andrea
authors: A
authors: Kappacher
authors: Sabine
authors: S
authors: Rosenlechner
authors: Richard
authors: R
authors: Greil