title: Unprecedented Cu-catalyzed coupling of internal 1,3-diynes with azides: one-pot tandem cyclizations involving 1,3-dipolar cycloaddition and carbocyclization furnishing naphthotriazoles.
abstract: A one-pot protocol for the synthesis of triazole-annulated polyheterocycles via metal-catalyzed coupling of internal 1,4-disubstituted 1,3-diynes and organic azides has been described. The mechanistic rationale for the reaction suggests tandem cyclizations involving copper-catalyzed cycloaddition and 6-endo carbocyclization reactions. The cascade cyclization leads to an increase in molecular complexity to furnish naphtho[1,2-d]triazoles in satisfactory yields. The generality of the method has been demonstrated by using a series of aromatic/aliphatic azides and symmetrical internal 1,3-diynes.
authors: Medicinal Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India.
authors: Anil K
authors: AK
authors: Mandadapu
authors: Sudhir K
authors: SK
authors: Sharma
authors: Sahaj
authors: S
authors: Gupta
authors: Deevi G Venkata
authors: DG
authors: Krishna
authors: Bijoy
authors: B
authors: Kundu