title: Evaluation of hypercoagulability in obese children with thrombin generation test and microparticle release: effect of metabolic parameters.
abstract: Obesity is associated with a hypercoagulable state. Thrombin generation test (TGT) and microparticle levels were not studied in obese children extensively. It is aimed to determine whether any differences in the coagulation system between obese and normal weighed children exist with the use of TGT and microparticles release. A total of 120 obese and 38 healthy children were included to the study. An increase of thrombin generation and microparticles levels were found in obese children. Hyperinsulinism could not find a risk factor for hypercoagulability in our obese children. None of the parameters of TGT has been shown to be related to metabolic parameters and metabolic syndrome. Microparticles release time is found to correlate only to body mass index (BMI) Standard deviation score (SDS) in obese children. Hypercoagulability is associated with childhood obesity. Significant correlation between degree of obesity and microparticles release suggested that high adipokine levels secreted from adipose tissue can stimulate procoagulant status-independent metabolic dearrangements.
authors: Department of Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey. zeynepsklr@gmail.com
authors: Zeynep
authors: Z
authors: Siklar
authors: Gönül
authors: G
authors: Öçal
authors: Merih
authors: M
authors: Berberoğlu
authors: Bülent
authors: B
authors: Hacihamdioğlu
authors: Senay
authors: S
authors: Savas Erdeve
authors: Yonca
authors: Y
authors: Eğin
authors: Nejat
authors: N
authors: Akar