title: Synthesis of key fragments of leiodelide A.
abstract: The synthesis of all key fragments of the marine macrolide leiodelide A is described. The polyoxygenated northern subunit is derived from d-xylose, while the southern subunit is rapidly assembled via an aldol reaction and Horner-Wadsworth-Emmons olefination. This highly convergent approach will allow for rapid modification and assembly of several isomers of leiodelide A, which may be necessary considering the assignment of leiodelide B has been previously shown to be incorrect.
authors: Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
authors: Mathieu F
authors: MF
authors: Chellat
authors: Nicolas
authors: N
authors: Proust
authors: Matthew G
authors: MG
authors: Lauer
authors: James P
authors: JP
authors: Stambuli