title: In vitro suppression of quercetin on hypertrophy and extracellular matrix accumulation in rat glomerular mesangial cells cultured by high glucose.
abstract: Quercetin's protective effects on the glomerulosclerosis of diabetic nephropathy (DN) in rat mesangial cells were investigated. The cell cycles, type IV collagen and laminin, TGF-β(1) mRNA, Smad 2/3 and Smad 7, and activities of cell antioxidases were measured. Compared with the high glucose group, quercetin may decrease the cell percentages of G(0)/G(1) phase, Smad 2/3 expression, laminin and type IV collagen, and TGF-β(1) mRNA level significantly. The antioxidant capacity, the cell percentages of S phase and Smad 7 expression was significantly increased by quercetin. These results suggest that quercetin is a protective agent against glomerulosclerosis in DN.
authors: Department of Pharmaceutical Analysis, School of Pharmacy, Xuzhou Medical College, Xuzhou 221004, China.
authors: Dao-quan
authors: DQ
authors: Tang
authors: Ya-qin
authors: YQ
authors: Wei
authors: Xiao-xing
authors: XX
authors: Yin
authors: Qian
authors: Q
authors: Lu
authors: Hui-hui
authors: HH
authors: Hao
authors: Yun-peng
authors: YP
authors: Zhai
authors: Jian-yun
authors: JY
authors: Wang
authors: Jin
authors: J
authors: Ren