title: Oncogenes and tumor-suppressor genes - 2 different looks of the same gene.
abstract: Dominant oncogenes and recessive tumor suppressor genes are widely implicated in the pathogenesis of human neoplasia. Several recent experimental findings suggested that an oncogene and a tumor suppressor gene can share a similar ontogeny from the parental normal 'in vivo' gene. At least three mechanisms have been demonstrated to be responsible for this ambivalent expression: the mutations located in different regions of the gene, transcriptional and post-transcriptional events (especially alternative splicing) and cell- and/or time-dependent control of gene expression. There are also evolutionary explanations for the existence of such genes with ambivalent expression.
authors: G
authors: G
authors: Calin