title: Signal transduction mediated through adhesion-GPCRs.
abstract: The signaling cascade of most adhesion-GPCRs remains uncharacterized, as the majority are still orphan receptors and further complicated by their unique structure containing a cleaved long extracellular domain (ECD) and a seven-transmembrane domain (7TM). In this chapter, we review previous reports which suggest G protein-dependent and -independent signaling pathways of adhesion-GPCRs and present our approach to investigate the signal transduction of the adhesion-GPCR, GPR56.
authors: Norikazu
authors: N
authors: Mizuno
authors: Hiroshi
authors: H
authors: Itoh