title: The enhanced antitumor-activity of DNA topoisomerase ii-trapping drugs by natural human tumor-necrosis-factor against human glioma cell-lines in-vitro.
abstract: We investigated the antitumor activity of human natural tumor necrosis factor (n-TNF) either alone or in combination with chemotherapeutic drugs on human glioma cell lines in vitro. Although the cytotoxic effect of n-TNF alone did not exceed 30%, n-TNF, in combination with topoisomerase II-trapping drugs, such as actinomycin D (ACD) and daunomycin (DAM), demonstrated a striking synergistic enhancement of the cytotoxicity, and reached a level of more than 80%, against all the tested cell lines. Thus this new combination therapy is considered to be a promising candidate in developing a new treatment approach to glioma patients.
authors: UNIV HAMBURG,DEPT NEUROPATHOL,D-20246 HAMBURG,GERMANY. KYUSHU UNIV,DEPT NEUROSURG,HIGASHI KU,FUKUOKA 812,JAPAN.
authors: K
authors: K
authors: Kamikaseda
authors: D
authors: D
authors: Stavrou
authors: M
authors: M
authors: Fukui