title: Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.
abstract: We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression.
authors: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.
authors: Xiaomu
authors: X
authors: Wei
authors: Angela
authors: A
authors: Moncada-Pazos
authors: Santiago
authors: S
authors: Cal
authors: Clara
authors: C
authors: Soria-Valles
authors: Jared
authors: J
authors: Gartner
authors: Udo
authors: U
authors: Rudloff
authors: Jimmy C
authors: JC
authors: Lin
authors: Steven A
authors: SA
authors: Rosenberg
authors: Carlos
authors: C
authors: López-Otín
authors: Yardena
authors: Y
authors: Samuels
references: Mol Aspects Med. 2008 Oct;29(5):258-89
references: 18762209
references: Nature. 2007 Mar 8;446(7132):153-8
references: 17344846
references: Nat Genet. 2005 Oct;37(10):1047-54
references: 16142232
references: Nat Genet. 2009 May;41(5):518-20
references: 19330028
references: J Biol Chem. 1989 May 15;264(14):8012-8
references: 2470739
references: Nucleic Acids Res. 2010 Jan;38(Database issue):D142-8
references: 19843607
references: Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43
references: 15688065
references: Nature. 2008 Oct 23;455(7216):1061-8
references: 18772890
references: Curr Opin Struct Biol. 1995 Jun;5(3):383-90
references: 7583637
references: Science. 2008 Sep 26;321(5897):1801-6
references: 18772397
references: Nucleic Acids Res. 2003 Jul 1;31(13):3812-4
references: 12824425
references: Science. 2000 Aug 25;289(5483):1360-5
references: 10958785
references: Nature. 2010 Jan 14;463(7278):191-6
references: 20016485
references: CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
references: 19474385
references: Nat Genet. 2006 Dec;38(12):1457-62
references: 17115056
references: Genome Res. 1998 Mar;8(3):195-202
references: 9521923
references: Genes Dev. 2003 Jan 1;17(1):7-30
references: 12514095
references: FEBS Lett. 1993 Sep 27;331(1-2):134-40
references: 8405391
references: Science. 2008 Sep 26;321(5897):1807-12
references: 18772396
references: Science. 1999 Jan 1;283(5398):91-4
references: 9872749
references: Nat Genet. 2009 Oct;41(10):1127-32
references: 19718025
references: Cancer Res. 2009 Jun 1;69(11):4926-34
references: 19458070
references: Science. 2006 Oct 13;314(5797):268-74
references: 16959974
references: J Clin Oncol. 2012 Jul 1;30(19):2348-53
references: 22529266
references: Science. 1998 Nov 13;282(5392):1281-4
references: 9812885
references: J Biol Chem. 2008 Nov 7;283(45):30433-7
references: 18650443
references: Nucleic Acids Res. 2008 Jan;36(Database issue):D281-8
references: 18039703
references: Am J Pathol. 2002 Feb;160(2):549-57
references: 11839575
references: Nucleic Acids Res. 2008 Jan;36(Database issue):D735-40
references: 18056084
references: Nat Rev Cancer. 2010 Apr;10(4):278-92
references: 20300104
references: J Cell Sci. 1999 Nov;112 ( Pt 21):3603-17
references: 10523497
references: Nature. 2010 Jan 21;463(7279):360-3
references: 20054297
references: Science. 2007 Nov 16;318(5853):1108-13
references: 17932254