title: ParkDB: a Parkinson's disease gene expression database.
abstract: Parkinson's disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and dopaminergic neuron differentiation under different biological conditions and across species. Database URL: http://www2.cancer.ucl.ac.uk/Parkinson_Db2/
authors: UCL, Department of Cancer Biology, University College London, Gower Street, London, UK.
authors: Cristian
authors: C
authors: Taccioli
authors: Jesper
authors: J
authors: Tegnér
authors: Vincenza
authors: V
authors: Maselli
authors: David
authors: D
authors: Gomez-Cabrero
authors: Gioia
authors: G
authors: Altobelli
authors: Warren
authors: W
authors: Emmett
authors: Francesco
authors: F
authors: Lescai
authors: Stefano
authors: S
authors: Gustincich
authors: Elia
authors: E
authors: Stupka
references: Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):955-60
references: 17215369
references: J Biol Chem. 2010 Jun 11;285(24):18565-74
references: 20395301
references: J Proteome Res. 2008 Feb;7(2):666-77
references: 18173235
references: Neurogenetics. 2006 Mar;7(1):1-11
references: 16344956
references: Nucleic Acids Res. 2002 Jan 1;30(1):38-41
references: 11752248
references: FASEB J. 2002 Nov;16(13):1826-8
references: 12223445
references: Bioinformatics. 2004 Dec 12;20(18):3705-6
references: 15297296
references: Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15454-9
references: 19717439
references: Nucleic Acids Res. 2003 Jan 1;31(1):68-71
references: 12519949
references: Neurobiol Dis. 2007 Jun;26(3):606-14
references: 17412603
references: Lancet. 2004 May 29;363(9423):1783-93
references: 15172778
references: Nucleic Acids Res. 2001 Jan 1;29(1):152-5
references: 11125075
references: Brain Res. 1995 Oct 30;697(1-2):35-43
references: 8593592
references: Lancet Neurol. 2006 Jun;5(6):525-35
references: 16713924
references: Hum Mol Genet. 2009 Apr 15;18(R1):R48-59
references: 19297401
references: Br Med Bull. 2008;86:109-27
references: 18398010
references: Am J Med Genet B Neuropsychiatr Genet. 2005 Aug 5;137B(1):5-16
references: 15965975
references: PLoS Genet. 2007 Jun;3(6):e98
references: 17571925
references: PLoS One. 2009;4(3):e4977
references: 19305503
references: Methods Mol Biol. 2003;224:111-36
references: 12710670
references: Bioinformatics. 2005 Aug 15;21(16):3439-40
references: 16082012
references: Neurobiol Dis. 2008 Mar;29(3):515-28
references: 18191405
references: Methods Mol Biol. 2006;338:175-90
references: 16888359
references: Bioinformatics. 2003 Jan;19(1):155-6
references: 12499308