title: p53 as tumor marker for the early detection of reincidence in lung cancer.
abstract: To examine the p53 expression in cancer development, we studied the case of a 59-year-old male suffering from squamous cell lung cancer. He was submitted to surgery for resection of the tumoral mass. Through immunoblot and immunohistochemical analysis, the tumor fragment was shown to bear p53 and hsp70 accumulation not detected in the normal lung tissue sample. Six months later, immunohistochemical analysis of a biopsy sample taken from the previous tumor site showed p53 accumulation. Considering the high specificity for p53 detection (100%), this result suggests probable tumor reincidence, not detected by the ordinary H&E staining.
authors: FED UNIV RIO DE JANEIRO,INST BIOFIS CARLOS CHAGAS FILHO,CTR CIENCIAS SAUDE,BR-21949900 RIO JANEIRO,BRAZIL. FED UNIV RIO DE JANEIRO,HOSP UNIV CLEMENTINO FRAGA FILHO,DEPT PATOL,BR-21941590 RIO JANEIRO,BRAZIL. FED UNIV RIO DE JANEIRO,HOSP UNIV CLEMENTINO FRAGA FILHO,SERV PNEUMOL,BR-21941590 RIO JANEIRO,BRAZIL.
authors: N
authors: N
authors: Silva
authors: M
authors: M
authors: Costa
authors: K
authors: K
authors: Madi
authors: L
authors: L
authors: Barbosa
authors: S
authors: S
authors: Rosas
authors: M
authors: M
authors: Carvalho