title: Analysis of prognostic factors of pediatric-type sarcomas in adult patients.
abstract: OBJECTIVE
  Pediatric-type sarcomas such as Ewing's sarcoma (EWS)/primitive neuroectodermal tumor family and rhabdomyosarcoma are relatively uncommon in adult patients. Optimal treatment strategies for this population and prognosis in adult patients compared with pediatric patients remain controversial.
  
  
  METHODS
  We retrospectively reviewed pediatric-type sarcoma patients older than 15 years at a single institution.
  
  
  RESULTS
  A total of 84 consecutive patients between 1995 and 2009 were identified at the Samsung Medical Center, Seoul, Korea. Median age was 30 years with a range of 15-74 years. Forty-seven patients (56.0%) were diagnosed with Ewing's sarcoma/primitive neuroectodermal tumor family, 34 (40.5%) with rhabdomyosarcoma and 3 (3.6%) with desmoplastic round-cell tumor. Median follow-up duration was 5.9 years. Median overall survival for all patients was 33.1 months (95% CI 13.5-52.7) and median event-free survival for all patients was 14.4 months (95% CI 5.9-22.9 months). Multivariate analysis revealed that localized disease was a significant independent prognostic factor for longer overall survival (hazard ratio 0.30, 95% CI 0.14-0.66, p = 0.003), and favorable primary tumor sites were associated with longer event-free survival (hazard ratio 0.33, 95% CI 0.11-0.98, p = 0.045).
  
  
  CONCLUSIONS
  We identified the prognostic variables which may facilitate risk-adapted therapies for this rare adult sarcoma group, which should be further investigated.
authors: Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Hee Kyung
authors: HK
authors: Ahn
authors: Ji Eun
authors: JE
authors: Uhm
authors: Jeeyun
authors: J
authors: Lee
authors: Do Hoon
authors: DH
authors: Lim
authors: Sung Wook
authors: SW
authors: Seo
authors: Ki-Sun
authors: KS
authors: Sung
authors: Su Jin
authors: SJ
authors: Lee
authors: Duk Joo
authors: DJ
authors: Lee
authors: Kyung Kee
authors: KK
authors: Baek
authors: Won-Seog
authors: WS
authors: Kim
authors: Joon Oh
authors: JO
authors: Park