title: Spontaneously hypertensive rat (SHR) as an animal model for ADHD: a short overview.
abstract: Diverse studies indicate that attention-deficit hyperactivity disorder (ADHD) is associated with alterations in encoding processes, including working or short-term memory. Some ADHD dysfunctional domains are reflected in the spontaneously hypertensive rat (SHR). Because ADHD, drugs and animal models are eliciting a growing interest, hence the aim of this work is to present a brief overview with a focus on the SHR as an animal model for ADHD and memory deficits. Thus, this paper reviews the concept of SHR as a model system for ADHD, comparing SHR, Wistar-Kyoto and Sprague-Dawley rats with a focus on the hypertension level and working, short-term memory and attention in different behavioral tasks, such as open field, five choice serial reaction time, water maze, passive avoidance, and autoshaping. In addition, drug treatments (d-amphetamine and methylphenidate) are evaluated.
authors: Department of Pharmacobiology, CINVESTAV, Tenorios 235, Granjas Coapa, Mexico City 14330, Mexico. ameneses@msn.com
authors: Alfredo
authors: A
authors: Meneses
authors: Georgina
authors: G
authors: Perez-Garcia
authors: Teresa
authors: T
authors: Ponce-Lopez
authors: Ruth
authors: R
authors: Tellez
authors: Andrea
authors: A
authors: Gallegos-Cari
authors: Carlos
authors: C
authors: Castillo