title: Targeting nicotine addiction: the possibility of a therapeutic vaccine.
abstract: Cigarette smoking is the primary cause of lung cancer, cardiovascular diseases, reproductive disorders, and delayed wound healing all over the world. The goals of smoking cessation are both to reduce health risks and to improve quality of life. The development of novel and more effective medications for smoking cessation is crucial in the treatment of nicotine dependence. Currently, first-line smoking cessation therapies include nicotine replacement products and bupropion. The partial nicotinic receptor agonist, varenicline, has recently been approved by the US Food and Drug Administration (FDA) for smoking cessation. Clonidine and nortriptyline have demonstrated some efficacy, but side effects may limit their use to second-line treatment products. Other therapeutic drugs that are under development include rimonabant, mecamylamine, monoamine oxidase inhibitors, and dopamine D3 receptor antagonists. Nicotine vaccines are among newer products seeking approval from the FDA. Antidrug vaccines are irreversible, provide protection over years and need booster injections far beyond the critical phase of acute withdrawal symptoms. Interacting with the drug in the blood rather than with a receptor in the brain, the vaccines are free of side effects due to central interaction. For drugs like nicotine, which interacts with different types of receptors in many organs, this is a further advantage. Three anti-nicotine vaccines are today in an advanced stage of clinical evaluation. Results show that the efficiency of the vaccines is directly related to the antibody levels, a fact which will help to optimize the vaccine effect. The vaccines are expected to appear on the market between 2011 and 2012.
authors: Unidad de Investigación Multidisciplinaria, Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México, México.
authors: José Juan
authors: JJ
authors: Escobar-Chávez
authors: Clara Luisa
authors: CL
authors: Domínguez-Delgado
authors: Isabel Marlen
authors: IM
authors: Rodríguez-Cruz
references: Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003086
references: 17054160
references: J Am Chem Soc. 2003 Jun 18;125(24):7164-5
references: 12797775
references: Tob Induc Dis. 2002 Jan 15;1(1):35-81
references: 19570247
references: Arch Bronconeumol. 2005 Jan;41(1):2-4
references: 15676128
references: Int Immunopharmacol. 2003 Jan;3(1):137-46
references: 12538044
references: Onkologie. 2002 Oct;25(5):406-11
references: 12415193
references: Biol Psychiatry. 2005 Jul 15;58(2):158-64
references: 16038686
references: Respiration. 2002;69(3):247-53
references: 12097769
references: Curr Drug Discov Technol. 2009 Sep;6(3):171-85
references: 19496753
references: Trends Pharmacol Sci. 2003 Sep;24(9):493-9
references: 12967775
references: Med Clin North Am. 2004 Nov;88(6):1399-413, ix
references: 15464104
references: Br J Pharmacol. 1998 Jun;124(3):455-64
references: 9647468
references: Curr Opin Pharmacol. 2004 Feb;4(1):36-46
references: 15018837
references: J Neurochem. 1997 Apr;68(4):1511-9
references: 9084421
references: N Engl J Med. 1999 Mar 4;340(9):685-91
references: 10053177
references: Curr Med Res Opin. 2008 Jul;24(7):1931-41
references: 18513462
references: Drug Alcohol Depend. 2010 Oct 1;111(3):200-6
references: 20542391
references: Addict Behav. 2004 Dec;29(9):1763-78
references: 15530720
references: MMWR Morb Mortal Wkly Rep. 2002 May 17;51(19):409-12
references: 12033476
references: Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1799-804
references: 17021350
references: Addict Behav. 2007 May;32(5):1094-8
references: 16876332
references: JAMA. 2002 Jul 24-31;288(4):468-74
references: 12132977
references: BMJ. 1999 Jan 30;318(7179):285-8
references: 9924052
references: JAMA. 2006 Jul 5;296(1):64-71
references: 16820548
references: Arch Intern Med. 1998 Oct 12;158(18):2035-9
references: 9778204
references: Schizophr Res. 2009 Dec;115(2-3):317-24
references: 19700263
references: Drug Metab Dispos. 2005 Jul;33(7):1056-61
references: 15843487
references: Clin Pharmacol Ther. 2005 Nov;78(5):456-67
references: 16321612
references: J Med Ethics. 2004 Aug;30(4):344-5
references: 15289514
references: Am J Public Health. 1994 Apr;84(4):543-7
references: 8154552
references: Vaccine. 2002 Jan 15;20(7-8):1196-204
references: 11803082
references: J Neurosci. 2003 Apr 15;23(8):3176-85
references: 12716925
references: Arch Gen Psychiatry. 2002 Oct;59(10):930-6
references: 12365880
references: BMJ. 2004 Jun 26;328(7455):1519
references: 15213107
references: N Engl J Med. 1997 Oct 23;337(17):1195-202
references: 9337378
references: Arch Intern Med. 2006 Aug 14-28;166(15):1561-8
references: 16908788
references: J Neurobiol. 2002 Dec;53(4):606-17
references: 12436424
references: Psychopharmacology (Berl). 2006 Mar;184(3-4):523-39
references: 16220335
references: Clin Pharmacol Ther. 1996 Nov;60(5):568-75
references: 8941030
references: PLoS One. 2008 Jun 25;3(6):e2547
references: 18575629
references: Nicotine Tob Res. 2001 Aug;3(3):203-23
references: 11506765
references: J Consult Clin Psychol. 1993 Oct;61(5):743-50
references: 8245272
references: Recent Results Cancer Res. 2005;166:167-75
references: 15648190
references: Przegl Lek. 2006;63(10):1114-8
references: 17288232
references: Psychopharmacology (Berl). 1997 Mar;130(1):28-40
references: 9089846
references: N Engl J Med. 1988 Nov 17;319(20):1318-30
references: 3054551
references: Physiol Behav. 2007 Jan 30;90(1):54-8
references: 17049956
references: Nicotine Tob Res. 2001 May;3(2):151-5
references: 11403729
references: Bioorg Med Chem. 2004 Feb 1;12(3):563-70
references: 14738965
references: Chest. 2002 Aug;122(2):403-8
references: 12171809
references: Clin Ther. 2007 Jun;29(6):1040-56
references: 17692720
references: Prog Neuropsychopharmacol Biol Psychiatry. 2004 Mar;28(2):319-27
references: 14751429
references: J Neurosci. 2002 Oct 15;22(20):8785-9
references: 12388584
references: CMAJ. 2008 Jul 15;179(2):135-44
references: 18625984
references: Eur J Pharmacol. 2000 Mar 30;393(1-3):141-6
references: 10771007
references: Prim Care. 1999 Sep;26(3):611-31
references: 10436290
references: Arch Gen Psychiatry. 1991 Dec;48(12):1069-74
references: 1845224
references: Int J Immunopharmacol. 2000 Oct;22(10):809-19
references: 10963853
references: Toxicon. 2004 May;43(6):619-32
references: 15109883
references: IDrugs. 2002 Nov;5(11):1070-4
references: 12800060
references: Int Immunopharmacol. 2008 Nov;8(11):1589-94
references: 18656557
references: Expert Opin Pharmacother. 2001 Oct;2(10):1545-55
references: 11825298
references: Auton Neurosci. 2011 Feb 24;160(1-2):53-8
references: 21036110
references: J Pharmacol Exp Ther. 1997 Dec;283(3):1076-81
references: 9399979
references: Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006219
references: 19160269
references: Annu Rev Pharmacol Toxicol. 2007;47:541-64
references: 17209799
references: Arch Intern Med. 2006 Aug 14-28;166(15):1571-7
references: 16908789
references: Arch Gen Psychiatry. 1998 Aug;55(8):683-90
references: 9707377
references: Respir Med. 2009 Jul;103(7):963-74
references: 19285850
references: Psychopharmacology (Berl). 2006 Mar;184(3-4):409-16
references: 15991003
references: Br J Addict. 1991 Aug;86(8):991-8
references: 1833003
references: CA Cancer J Clin. 2005 Sep-Oct;55(5):281-99; quiz 322-3, 325
references: 16166074
references: J Clin Endocrinol Metab. 2009 Dec;94(12):4898-906
references: 19846734
references: Clin Pharmacol Ther. 2008 Apr;83(4):619-21
references: 18091758
references: Eur J Immunol. 2005 Jul;35(7):2031-40
references: 15971275
references: MMWR Morb Mortal Wkly Rep. 2001 Oct 12;50(40):869-73
references: 11666113
references: Cardiol Rev. 2006 Mar-Apr;14(2):57-73
references: 16493243
references: J Consult Clin Psychol. 2010 Feb;78(1):24-33
references: 20099947
references: Psychopharmacology (Berl). 1999 Jul;145(1):1-20
references: 10445368
references: Curr Opin Mol Ther. 2006 Feb;8(1):11-6
references: 16506520
references: Prev Med. 1995 Jan;24(1):41-7
references: 7740014
references: Neurosci Biobehav Rev. 2010 Mar;34(3):295-342
references: 19665479
references: Clin Pharmacol Ther. 1995 Oct;58(4):444-52
references: 7586937
references: Respiration. 2002;69(3):254-60
references: 12097770
references: Expert Opin Emerg Drugs. 2004 May;9(1):39-53
references: 15155135
references: Clin Ther. 2007 Jun;29(6):1027-39
references: 17692719
references: J Pharmacol Exp Ther. 1988 Aug;246(2):619-27
references: 3404450
references: Pharmacol Biochem Behav. 2000 Jan 1;65(1):191-8
references: 10638653
references: JAMA. 2000 Aug 9;284(6):706-12
references: 10927778
references: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD000146
references: 18253970
references: Psychopharmacology (Berl). 1998 Aug;138(3-4):217-30
references: 9725745
references: Trends Neurosci. 1999 Dec;22(12):555-61
references: 10542436
references: Expert Opin Investig Drugs. 2007 Nov;16(11):1775-83
references: 17970637
references: Expert Rev Vaccines. 2004 Aug;3(4):386
references: 15270640
references: Lancet. 1992 Aug 8;340(8815):324-9
references: 1353803
references: Neuropsychopharmacology. 2000 May;22(5):451-65
references: 10731620
references: Food Chem Toxicol. 2004;42 Suppl:S53-83
references: 15072838
references: Nicotine Tob Res. 2004 Dec;6(6):899-912
references: 15801566
references: J Adolesc Health. 2007 Feb;40(2):144-50
references: 17259054
references: Curr Med Res Opin. 2007 Apr;23(4):793-801
references: 17407636
references: Arch Intern Med. 2000 Nov 13;160(20):3128-34
references: 11074742
references: J Consult Clin Psychol. 1999 Aug;67(4):547-54
references: 10450625
references: Psychol Med. 2004 Oct;34(7):1251-61
references: 15697051
references: Alaska Med. 1995 Apr-Jun;37(2):43-7
references: 7661325
references: Epidemiol Rev. 1995;17(1):48-65
references: 8521946
references: Curr Opin Investig Drugs. 2007 Jan;8(1):71-7
references: 17263188
references: J Chromatogr A. 2003 Oct 31;1017(1-2):187-93
references: 14584703
references: Nicotine Tob Res. 2005 Aug;7(4):491-9
references: 16085520
references: Addict Behav. 2010 Mar;35(3):229-34
references: 19926400
references: Addict Behav. 2008 Jan;33(1):173-9
references: 17587504
references: Drugs. 1995 Aug;50(2):197-207
references: 8521754
references: Ann Intern Med. 2004 Mar 16;140(6):426-33
references: 15023708
references: IDrugs. 2003 Dec;6(12):1178-81
references: 14666429
references: Cochrane Database Syst Rev. 2000;(2):CD000031
references: 10796472
references: Drug Alcohol Depend. 2004 Aug 16;75(2):193-8
references: 15276225
references: Addict Behav. 2000 Sep-Oct;25(5):653-62
references: 11023009
references: Bioorg Med Chem. 2004 Sep 15;12(18):4981-7
references: 15336277
references: Addict Behav. 1998 May-Jun;23(3):303-24
references: 9668929
references: Arch Intern Med. 1991 Oct;151(10):1993-8
references: 1929687
references: Addiction. 2004 Jan;99(1):83-92
references: 14678066
references: Cochrane Database Syst Rev. 2000;(2):CD001009
references: 10796584
references: Prev Med. 2000 Mar;30(3):209-16
references: 10684744
references: Arch Intern Med. 2002 Jun 10;162(11):1267-76
references: 12038945
references: J Med Ethics. 2005 Sep;31(9):558
references: 16131563
references: Clin Ther. 2009 Mar;31(3):463-91
references: 19393839
references: Drug Alcohol Rev. 2003 Jun;22(2):203-20
references: 12850907
references: Nicotine Tob Res. 2006 Feb;8(1):77-87
references: 16497602