title: Successful treatment of chronic pseudophakic macular edema (Irvine-Gass syndrome) with interferon alpha: a report of three cases.
abstract: OBJECTIVE
  To describe treatment of chronic Irvine-Gass syndrome (CME) with interferon (IFN) alpha.
  
  
  METHODS
  Interventional retrospective case series. IFN alpha-2a was administered at a dose of 3 million IU/day subcutaneously for 4 weeks, and was tapered thereafter. Treatment efficacy was assessed by best-corrected visual acuity (BCVA) and by optical coherence tomography (OCT).
  
  
  RESULTS
  Three patients (4 eyes) with chronic Irvine-Gass syndrome were treated. Ineffective pretreatment included local and systemic corticosteroids. Within 4 weeks, IFN alpha led to resolution of CME in all eyes. BCVA improved in 3 eyes and remained unchanged in 1 eye. During follow-up of 3-11 months no relapse of CME occurred. No systemic or local side effects were noted.
  
  
  CONCLUSIONS
  IFN alpha has been demonstrated to be a successful and well-tolerated treatment option for resistant chronic pseudophakic CME. Further studies are necessary to evaluate the role of IFN alpha in Irvine-Gass syndrome.
authors: Centre for Ophthalmology, University of Tübingen, Tübingen, Germany. christoph.deuter@med.uni-tuebingen.de
authors: Christoph M E
authors: CM
authors: Deuter
authors: Faik
authors: F
authors: Gelisken
authors: Nicole
authors: N
authors: Stübiger
authors: Manfred
authors: M
authors: Zierhut
authors: Deshka
authors: D
authors: Doycheva