title: Amyloidosis and Crohn´s disease.
abstract: Secondary amyloidosis is a rare but serious complication of inflammatory bowel disease that may influence the prognosis even more than the underlying disease. Due to a better knowledge of the association of secondary amyloidosis to inflammatory bowel disease, early diagnosis of this complication is becoming more frequent, but its treatment continues to pose a challenge. We report 4 cases of patients with Crohn´s disease and amyloidosis diagnosed in the inflammatory bowel disease Units of Toledo and Ciudad Real, which represent 0.68% of the patients with Crohn´s disease of our health areas. There have been not cases of amyloidosis in patients with ulcerative colitis. In our 4 patients the secondary amyloidosis was clearly related to Crohn´s disease,which was often of fistulising type. The predominant clinical picture of amyloidosis was nephrotic syndrome. The patients responded to medical and surgical treatment of Crohn´s disease and colchicine, which improved renal function in all cases except in one who required kidney transplantation.
authors: Departments of Gastroenterology, Hospital Virgen de la Salud, Toledo, Spain. tonig2004@terra.es
authors: Antonio
authors: A
authors: Guardiola-Arévalo
authors: Mariano
authors: M
authors: Alcántara-Torres
authors: Julio
authors: J
authors: Valle-Muñoz
authors: Rufo Humberto
authors: RH
authors: Lorente-Poyatos
authors: Marta
authors: M
authors: Romero-Gutiérrez
authors: Rufo
authors: R
authors: Rodríguez-Merlo
authors: Alejandro
authors: A
authors: Pérez-Martínez
authors: José María
authors: JM
authors: Carrobles-Jiménez