title: Exploiting Sm(II) and Sm(III) in SmI2-initiated reaction cascades: application in a tag removal-cyclisation approach to spirooxindole scaffolds.
abstract: A tag removal-cyclisation sequence is described that is initiated by reduction using a Sm(II) species and completed by a Sm(III) Lewis acid that is formed in an earlier stage. Therefore, the reaction cascade utilises both oxidation states of a samarium reagent in discrete steps and allows access to privileged, pyrrolidinyl-spirooxindole scaffolds and analogues inspired by the anti-cancer natural product spirotryprostatin A.
authors: School of Chemistry, University of Manchester, Oxford Road, Manchester, UK M13 9PL.
authors: Susannah C
authors: SC
authors: Coote
authors: Seidjolo
authors: S
authors: Quenum
authors: David J
authors: DJ
authors: Procter