title: N'-[(2-n-Butyl-4-chloro-1H-imidazol-5-yl)-methyl-idene]adamantane-1-carbo-hydrazide sesquihydrate ethanol hemi-solvate.
abstract: In the asymmetric unit of the title compound, C(19)H(27)ClN(4)O·0.5C(2)H(6)O·1.5H(2)O, there are two mol-ecules of the Schiff base, which has a rigid adamantyl cage at one end of the C(= O)NH-N=CH- chain and an almost planar [torsion angles = 1.3 (1) and 7.9 (2)° imidazolyl ring at the other end, three mol-ecules of water and one mol-ecule of ethanol. In both independent mol-ecules of the Schiff base, this chain displays an extended zigzag configuration. All their amino groups function as hydrogen-bond donors to water mol-ecules; these are linked to other acceptor atoms, generating a layer structure. O-H⋯O and O-H⋯N inter-actions involving the water mol-ecules also occur.
authors: Abdul-Malek S
authors: AM
authors: Al-Tamimi
authors: Ahmed
authors: A
authors: Bari
authors: Mohamed A
authors: MA
authors: Al-Omar
authors: Ali A
authors: AA
authors: El-Emam
authors: Seik Weng
authors: SW
authors: Ng
references: Eur J Med Chem. 2007 Feb;42(2):235-42
references: 17129641
references: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references: 18156677