title: Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system.
abstract: Cell survival proteins play an important role throughout nervous system development, normal physiological processes, and pathological conditions. Transmembrane BAX inhibitor motif 3 (TMBIM3, also known as GRINA), is a member of a family of proteins that contain a conserved BAX inhibitor-1 motif. This family of proteins includes several members that have been shown to protect cells from apoptosis. In this study, the authors show that TMBIM3 is expressed in the brain including high levels in the hippocampus. Biochemical and sequence analysis of TMBIM3 demonstrates that the rat, murine, and human genes encode an approximately 38 kDa protein with a predicted seven transmembrane domain topology. A Tmbim3 knockout mouse line did not have an obvious phenotype, but may prove useful in future studies of this family of proteins.
authors: Section of Developmental Genetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. joseph.nielsen@fda.hhs.gov
authors: Joseph A
authors: JA
authors: Nielsen
authors: Meredith A
authors: MA
authors: Chambers
authors: Elena
authors: E
authors: Romm
authors: Laurel Yong-Hwa
authors: LY
authors: Lee
authors: Jo Ann
authors: JA
authors: Berndt
authors: Lynn D
authors: LD
authors: Hudson
references: J Biol Chem. 1990 Sep 25;265(27):16195-204
references: 2168883
references: Nature. 1991 Nov 7;354(6348):70-3
references: 1719427
references: Nature. 2002 Jul 25;418(6896):443-7
references: 12140561
references: Genes Genet Syst. 2006 Feb;81(1):41-50
references: 16607040
references: J Neurochem. 2007 Oct;103(1):190-203
references: 17635665
references: Nucleic Acids Res. 2003 Jul 1;31(13):3625-30
references: 12824381
references: Nucleic Acids Res. 2002 May 1;30(9):e36
references: 11972351
references: PLoS Pathog. 2007 Feb;3(2):e17
references: 17319741
references: Mol Cell. 2004 Aug 13;15(3):355-66
references: 15304216
references: J Mol Biol. 1999 Dec 17;294(5):1351-62
references: 10600390
references: Mol Cell. 1998 Feb;1(3):337-46
references: 9660918
references: Curr Mol Med. 2008 Mar;8(2):148-56
references: 18336295
references: J Cell Biol. 1991 Oct;115(1):19-30
references: 1655802
references: J Biochem Mol Biol. 2002 Jan 31;35(1):61-6
references: 16248971
references: J Mol Biol. 2001 Jan 19;305(3):567-80
references: 11152613
references: Nat Cell Biol. 2001 Nov;3(11):E255-63
references: 11715037
references: J Mol Biol. 1997 Apr 25;268(1):78-94
references: 9149143