title: Human urinary peptide database for multiple disease biomarker discovery.
abstract: OBJECTIVE
  Human urine is an ideal candidate for use in clinical diagnostics. It is easily available, as untrained personnel can collect it. It correlates well with the pathophysiology of a number of diseases, making it a useful source for clinical proteomics.
  
  
  METHODS
  In this article, we give an update of the human urinary peptide database derived from over 13,000 data sets of CE-MS by now.
  
  
  RESULTS
  Urine samples from both patients and healthy subjects were analyzed by CE-MS; these included 47 different pathophysiological conditions. Besides defining biomarkers by their experimental parameters, information on their sequences provides fundamental data into the pathological pathways of diseases. Therefore, we have sequenced 953 urinary peptides by using state-of-the-art top-down MS/MS. Identified biomarkers of all clinical proteomic CE-MS studies including their regulation are also listed in this work.
  
  
  CONCLUSIONS
  Biomarker discovery can be used in the management of a wide range of diseases, by combining these data sets of the database. Taking this approach, we can reveal details, at a molecular level, on the pathogenesis of a number of diseases, in particular those associated with urine production and excretion.
authors: Mosaiques diagnostics GmbH, Hannover, Germany.
authors: Justyna
authors: J
authors: Siwy
authors: William
authors: W
authors: Mullen
authors: Igor
authors: I
authors: Golovko
authors: Julia
authors: J
authors: Franke
authors: Petra
authors: P
authors: Zürbig