title: [Influence of pertussis preparations on primary culture of peritoneal macrophages and continuous human monocyte-like cell line U937].
abstract: OBJECTIVE
  Selection of optimal tests for pertussis formulations (PF) cytotoxicity evaluation using mononuclear phagocytes model cells.
  
  
  METHODS
  A cellular pertussis vaccine, pertussis dialysated antigen and pertussis dialysated antigen fraction 2 cytotoxicity evaluation was performed by using primary mice peritoneal macrophage culture and human monocyte-like cell line U937.
  
  
  RESULTS
  Mononuclear phagocytes are a simple, sensitive and easily accessible model for PF cytotoxicity evaluation. The results of analysis are available within 6 hours.
  
  
  CONCLUSIONS
  This model may be recommended as screening test for detection of PF toxicity.
authors: S Iu
authors: SIu
authors: Tiukavkina
authors: A A
authors: AA
authors: Savis'ko
authors: G G
authors: GG
authors: Kharseeva