title: Detection of hepatitis B virus genome in hepatocellular carcinoma from both hepatitis B surface antigen- and antibody to hepatitis C virus-negative patients.
abstract: Twenty-two patients who tested seronegative for both hepatitis B virus (HBV) and hepatitis C virus (HCV) markers and undefined pathogenesis of hepatocellular carcinoma (HCC) were studied using polymerase chain reaction (PCR). Among these patients, 5 (23%) were positive for HBV-DNA in serum by PCR, but no patient was positive for HCV-RNA by reverse transcription PCR. Liver tissue specimens were available for analyzing HBV genome by PCR in 17 patients, and HBV sequences were detected in 10 (59%) patients. These results indicate that HBV is commonly implicated in serologically undefined pathogenesis of HCC in Japan.
authors: NAGASAKI UNIV, SCH MED, DEPT INTERNAL MED 1, NAGASAKI 852, JAPAN. NAGASAKI UNIV, HLTH RES CTR, NAGASAKI 852, JAPAN.
authors: H
authors: H
authors: Kamito
authors: K
authors: K
authors: Nakata
authors: K
authors: K
authors: Hamasaki
authors: M
authors: M
authors: Daikoku
authors: F
authors: F
authors: Mawatari
authors: T
authors: T
authors: Ueki
authors: Y
authors: Y
authors: Hayashida
authors: K
authors: K
authors: Nakao
authors: Y
authors: Y
authors: Kato
authors: S
authors: S
authors: Nagataki