title: Cardiac resynchronization therapy.
abstract: Systolic heart failure is a major problem for Americans today, with 550,000 new cases diagnosed per year, and ultimately contributes to 287,000 deaths annually. While pharmacologic therapy has drastically improved outcomes in patients with systolic heart failure, hospitalizations from systolic heart failure continue to increase and remain a major cost burden. In response to this unmet need, recent years have seen dramatic improvements in device-based therapy targeting one cause of systolic dysfunction: dyssynchronous ventricular contraction. Cardiac resynchronization therapy aims to restore mechanical synchrony by electrically activating the heart in a synchronized manner. This review summarizes the rationale for cardiac resynchronization therapy, evidence for its use, current guidelines, and ongoing and future directions for research.
authors: Division of Cardiology, Ochsner Clinic Foundation, New Orleans, LA.
authors: Joseph S
authors: JS
authors: Owen
authors: Sammy
authors: S
authors: Khatib
authors: Daniel P
authors: DP
authors: Morin
references: Ann Noninvasive Electrocardiol. 2005 Oct;10(4 Suppl):34-43
references: 16274414
references: Pacing Clin Electrophysiol. 1994 Nov;17(11 Pt 2):1974-9
references: 7845801
references: JAMA. 2003 May 28;289(20):2685-94
references: 12771115
references: JACC Cardiovasc Imaging. 2008 Sep;1(5):569-71
references: 19356482
references: JACC Cardiovasc Imaging. 2009 Apr;2(4):486-97
references: 19580733
references: J Am Coll Cardiol. 2008 Oct 7;52(15):1239-46
references: 18926327
references: Heart. 2003 Jan;89(1):54-60
references: 12482792
references: J Am Coll Cardiol. 2002 Jan 16;39(2):194-201
references: 11788207
references: Heart Rhythm. 2005 Jun;2(6):616-8
references: 15922269
references: N Engl J Med. 2005 Apr 14;352(15):1539-49
references: 15753115
references: J Am Coll Cardiol. 2009 Jan 27;53(4):355-60
references: 19161886
references: Curr Opin Cardiol. 2008 Sep;23(5):447-51
references: 18670255
references: Europace. 2008 May;10(5):566-71
references: 18390536
references: Circulation. 2008 May 20;117(20):2608-16
references: 18458170
references: Circulation. 2004 Jan 27;109(3):300-7
references: 14744954
references: J Am Coll Cardiol. 1998 Sep;32(3):695-703
references: 9741514
references: J Am Coll Cardiol. 2006 Aug 15;48(4):734-43
references: 16904542
references: Am J Cardiol. 2004 Dec 15;94(12):1506-9
references: 15589005
references: Cardiol J. 2009;16(3):197-209
references: 19437393
references: J Am Coll Cardiol. 2008 Dec 2;52(23):1834-1843
references: 19038680
references: N Engl J Med. 2007 Dec 13;357(24):2461-71
references: 17986493
references: JAMA. 2007 Jun 13;297(22):2502-14
references: 17565085
references: J Am Coll Cardiol. 2000 Mar 1;35(3):569-82
references: 10716457
references: N Engl J Med. 2001 Mar 22;344(12):873-80
references: 11259720
references: Eur J Heart Fail. 2006 Jun;8(4):433-40
references: 16507349
references: Indian Pacing Electrophysiol J. 2007 Oct 22;7(4):215-7
references: 17957269
references: N Engl J Med. 2004 May 20;350(21):2140-50
references: 15152059
references: Curr Opin Cardiol. 2006 Jan;21(1):20-6
references: 16355025
references: N Engl J Med. 1999 Sep 16;341(12):910-1
references: 10486424
references: N Engl J Med. 2002 Jun 13;346(24):1845-53
references: 12063368
references: J Am Coll Cardiol. 2008 May 20;51(20):1944-52
references: 18482662