title: Pre-emptive eculizumab and plasmapheresis for renal transplant in atypical hemolytic uremic syndrome.
abstract: The case of a 12-year-old with a hybrid CFH/CFHL1 gene and atypical hemolytic uremic syndrome (aHUS) that had previously developed native kidney and then renal allograft loss is reported. This case illustrates the relatively common occurrence of renal loss from the late presentation of aHUS. Also presented is a protocol for the pre-emptive use of eculizumab and plasmapheresis as part of a renal transplant plan for the treatment of aHUS in patients deemed at high risk for recurrent disease. This protocol was a result of a multidisciplinary approach including adult and pediatric nephrology, transplant surgery, transfusion medicine, and infectious disease specialists. This protocol and the justifications and components of it can function as a guideline for the treatment of a group of children that have waited in limbo for the first U.S. transplant to open the door to this type of definitive care for this devastating disease.
authors: Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA. carla-nester@uiowa.edu
authors: Carla
authors: C
authors: Nester
authors: Zoe
authors: Z
authors: Stewart
authors: David
authors: D
authors: Myers
authors: Jennifer
authors: J
authors: Jetton
authors: Ramesh
authors: R
authors: Nair
authors: Alan
authors: A
authors: Reed
authors: Christie
authors: C
authors: Thomas
authors: Richard
authors: R
authors: Smith
authors: Patrick
authors: P
authors: Brophy
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