title: F-cell levels are altered with erythrocyte density in sickle cell disease.
abstract: Lighter cells from density fractionated erythrocytes of sickle cell disease (SCD) patients carry higher amount of externalized phosphatidylserine (PS) and cell surface glycophorins compared to the denser counterparts. Further analysis also revealed that the denser cells contained higher levels of fetal hemoglobin (HbF) compared to the lighter cells, supported by the presence of larger number of F-cells in these populations. In this report, we have found direct evidence on the higher survival of the HbF rich erythrocytes in SCD.
authors: Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India.
authors: Sumanta
authors: S
authors: Basu
authors: Bisnu Prasad
authors: BP
authors: Dash
authors: Dilip Kumar
authors: DK
authors: Patel
authors: Sudipa
authors: S
authors: Chakravarty
authors: Amit
authors: A
authors: Chakravarty
authors: Debashis
authors: D
authors: Banerjee
authors: Abhijit
authors: A
authors: Chakrabarti