title: Association between microRNA196a2 rs11614913 genotypes and the risk of non-small cell lung cancer in Korean population.
abstract: OBJECTIVE
  The microRNA (miRNA) miR-196a2 may play an important role in lung cancer development and survival by altering binding activity of target mRNA. In this study, we evaluated their associations with the susceptibility of non-small cell lung cancers (NSCLC) by case-control study in a Korean population.
  
  
  METHODS
  We performed genotyping analyses for miR-196a2 rs11614913 T/C at miRNA regions in a case-control study using blood samples of 406 NSCLC patient and 428 cancer-free control groups.
  
  
  RESULTS
  The total C allele frequencies for miR-196a2 were 48.8% for the patients and 45.6% for the controls; and the genotype frequencies of TT, TC, and CC were 23.7%, 55.2%, and 21.1% for the patients and 31.1%, 46.35%, and 22.4% for the controls (p<0.05). Participants who possesses TC/CC genotypes showed high risk for NSCLC compared to those possessed TT genotypes (OR, 1.42; 95% CI, 1.03 to 1.96). The association was persisted in 60 and older age group, male, smokers, those without family history for cancer. However, no significant association of CC genotypes in recessive genetic model was observed.
  
  
  CONCLUSIONS
  In conclusion, this case-control study provides evidence that miR-196a2 rs11614913 C/T polymorphisms are associated with a significantly increased risk of NSCLC in a dominant model, indicating that common genetic polymorphisms in miR-196a2 rs11614913 are associated with NSCLC. The association of miR196a2 rs11614913 polymorphisms and NSCLC risk require confirmation through additional larger studies.
authors: Department of Preventive Medicine, Dong-A University College of Medicine, Busan, Korea. yshong@dau.ac.kr
authors: Young-Seoub
authors: YS
authors: Hong
authors: Ho-Jin
authors: HJ
authors: Kang
authors: Jong-Young
authors: JY
authors: Kwak
authors: Byung Lae
authors: BL
authors: Park
authors: Chang-Hun
authors: CH
authors: You
authors: Yu-Mi
authors: YM
authors: Kim
authors: Heon
authors: H
authors: Kim
references: Retrovirology. 2007 Jan 25;4:5
references: 17442096
references: Cancer Res. 2007 Feb 15;67(4):1419-23
references: 17308078
references: Science. 2001 Oct 26;294(5543):862-4
references: 11679672
references: Cell. 2007 Apr 20;129(2):303-17
references: 17397913
references: Hum Mutat. 2009 Aug;30(8):1231-6
references: 19514064
references: Cancer Res. 2007 Jun 1;67(11):5148-55
references: 17545593
references: Cell. 2003 Jun 13;113(6):673-6
references: 12809598
references: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9
references: 12434020
references: J Clin Invest. 2008 Jul;118(7):2600-8
references: 18521189
references: Cell. 2004 Jan 23;116(2):281-97
references: 14744438
references: Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1183-7
references: 19293314
references: Cardiovasc Res. 2008 Sep 1;79(4):562-70
references: 18511432
references: Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18255-60
references: 17108080
references: Nat Genet. 2007 May;39(5):673-7
references: 17401365
references: Science. 2001 Oct 26;294(5543):797-9
references: 11679654
references: Nat Rev Cancer. 2006 Apr;6(4):259-69
references: 16557279
references: Leuk Lymphoma. 2007 Feb;48(2):410-2
references: 17325905
references: Cancer Res. 2004 Jun 1;64(11):3753-6
references: 15172979
references: Science. 2001 Oct 26;294(5543):853-8
references: 11679670
references: Clin Chim Acta. 2010 Sep 6;411(17-18):1287-90
references: 20488170
references: Hum Mutat. 2009 Jan;30(1):79-84
references: 18634034
references: Nature. 2005 Jun 9;435(7043):834-8
references: 15944708
references: Circ Res. 2007 Feb 16;100(3):416-24
references: 17234972
references: Science. 2007 Apr 27;316(5824):575-9
references: 17379774
references: Cancer Res. 2009 Jul 15;69(14):5970-7
references: 19567675
references: Cancer Res. 2005 Nov 1;65(21):9628-32
references: 16266980