title: The potent anti-inflammatory agent escin does not increase corticosterone secretion and immune cell apoptosis in mice.
abstract: Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 days before observing the relevant parameters. The results showed that escin exhibits a potent anti-inflammatory effect, but does not increase corticosterone secretion in mice, and does not increase immune cell apoptosis in the spleen and thymus of mice. These findings suggest that the anti-inflammatory effect of escin is not dependent on the release of corticosterone.
authors: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, PR China.
authors: Leiming
authors: L
authors: Zhang
authors: Hongsheng
authors: H
authors: Wang
authors: Huaying
authors: H
authors: Fan
authors: Tian
authors: T
authors: Wang
authors: Na
authors: N
authors: Jiang
authors: Pengfei
authors: P
authors: Yu
authors: Fenghua
authors: F
authors: Fu