title: Genetic variants in ADIPOQ gene and the risk of type 2 diabetes: a case-control study of Chinese Han population.
abstract: This study was to evaluate the association between ADIPOQ gene variants and type 2 diabetes mellitus (T2DM). TaqMan(®) assay was performed to test the genotypes in T2DM patients (n = 1,105) and normal control subjects (n = 1,107). Serum adiponectin concentration was measured by ELISA kit. The variant genotypes rs7649121AT and rs7649121AT/TT, compared with the AA genotype, were associated with a significantly decreased risk of T2DM [Adjusted OR (95% CI) = 0.79(0.66-0.95), 0.80(0.67-0.96), respectively]. In stratified analysis, rs2241767AG genotype increased the risk of T2DM in obesity group [Adjusted OR (95% CI) = 1.32(1.03-1.69)]. Patients with genotype AG/GG of rs2241767 had lower levels of serum adiponectin than those with the genotype AA (P = 0.044). Haplotype analyses were not significant. Crossover analysis of rs7649121 and environmental risk factor (obesity) indicated that the protect effect of rs7649121AT/TT maybe offset by the environmental risk. Those who exposed to environmental risk factor (obesity) had a chance to attack T2DM compared with those who did not expose to the two factors [Adjusted OR (95% CI) = 1.64(1.30-2.06)]. This study suggested that the ADIPOQ gene polymorphisms were associated with the risk of T2DM in a Chinese Han population.
authors: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
authors: Wencong
authors: W
authors: Du
authors: Qian
authors: Q
authors: Li
authors: Ying
authors: Y
authors: Lu
authors: Xiaofang
authors: X
authors: Yu
authors: Xinhua
authors: X
authors: Ye
authors: Yanqin
authors: Y
authors: Gao
authors: Jianhua
authors: J
authors: Ma
authors: Jinluo
authors: J
authors: Cheng
authors: Yuanyuan
authors: Y
authors: Cao
authors: Juan
authors: J
authors: Du
authors: Hui
authors: H
authors: Shi
authors: Ling
authors: L
authors: Zhou
references: Diabetes Care. 2003 Jul;26(7):2015-20
references: 12832305
references: J Genet Genomics. 2009 Jul;36(7):417-23
references: 19631916
references: Biochem Biophys Res Commun. 2001 Feb 2;280(4):1120-9
references: 11162643
references: Int J Obes (Lond). 2006 Feb;30(2):226-32
references: 16231017
references: Diabetes. 2008 Dec;57(12):3353-9
references: 18776141
references: Curr Pharm Des. 2003;9(17):1411-8
references: 12769732
references: Diabetes. 2003 Feb;52(2):239-43
references: 12540592
references: Hum Genet. 2008 Jul;123(6):599-605
references: 18465144
references: Diabetes. 2006 Feb;55(2):523-9
references: 16443790
references: Diabetes. 2004 Jan;53(1):209-13
references: 14693717
references: Lancet. 2005 Apr 9-15;365(9467):1333-46
references: 15823385
references: Metabolism. 2010 Apr;59(4):492-501
references: 19846176
references: Clin Endocrinol (Oxf). 2008 Jun;68(6):885-9
references: 17980008
references: Am J Hum Genet. 2004 Jan;74(1):106-20
references: 14681826
references: Diabetes. 2005 Jan;54(1):268-74
references: 15616038
references: Endocr Rev. 2005 May;26(3):439-51
references: 15897298
references: Diabetes. 2005 Mar;54(3):893-9
references: 15734870
references: Bioinformatics. 2005 Jan 15;21(2):263-5
references: 15297300
references: Diabetes. 2004 Feb;53 Suppl 1:S31-5
references: 14749263
references: Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Feb;23(1):16-9
references: 12015102
references: Diabetes. 2004 Apr;53(4):1150-7
references: 15047634