title: End-stage renal disease among living-kidney donors: single-center experience.
abstract: OBJECTIVE
  Renal transplant from living donors is widely accepted as a highly effective treatment for end-stage renal disease. Donors undergo a major operation with considerable perioperative risks of morbidity and mortality. Living with a single kidney also confers long-term risks. This study sought the incidence and causes of end-stage renal disease among living kidney donors.
  
  
  METHODS
  This study included all donors who had reached end-stage renal disease among 2000 consecutive living-kidney donors. All operations and follow-up were performed in a single center. We studied the onset of renal disease, cause of end-stage renal disease, date of replacement therapy, and outcome. We also revised the donor's medical records related to their corresponding recipients.
  
  
  RESULTS
  Of 2000 living donors, 8 developed end-stage renal disease; 6 were men (mean age, 30.87 ± 5.84 years. Renal failure occurred 5 to 27 years after donation. Renal transplant was done in 1 donor. Medical complications were proteinuria (6 patients), hypertension (7 patients), diabetes (3 patients), gout (3 patients), ischemic heart disease (5 patients), and hepatitis viral infection (4 patients). The causes of end-stage renal disease were diabetic nephropathy in 3 patients. Other possible causes included toxic nephropathy, chronic pyelonephritis, and preeclampsia.
  
  
  CONCLUSIONS
  Living kidney donation is safe, and development of renal failure after donation is caused by the same causes as in the general population.
authors: Department of Nephrology, Urology and Nephrology Center, Mansoura University, 35516 Mansoura, Egypt.
authors: Ehab W
authors: EW
authors: Wafa
authors: Ayman F
authors: AF
authors: Refaie
authors: Tarek M
authors: TM
authors: Abbas
authors: Mohamed A
authors: MA
authors: Fouda
authors: Hussein A
authors: HA
authors: Sheashaa
authors: Amani
authors: A
authors: Mostafa
authors: Mohamed I
authors: MI
authors: Abo El Ghar
authors: Mohamed A
authors: MA
authors: Ghoneim