title: Immunohistochemical detection of nm23-H1/NDP kinase in childhood thyroid carcinoma.
abstract: Childhood thyroid cancer is known to be aggressive. High incidence of lymph node and distant metastasis are characteristic features of these cases. In adult, reduced expression of nm23-H1/nucleoside diphosphate (NDP) kinase has been correlated with cancer invasion and metastasis in some tumor types. Therefore, we examined the expression of nm23-H1 gene product in childhood thyroid carcinomas in Japan. 27 primary thyroid carcinomas and 8 metastatic lymph nodes were analyzed by immunohistochemistry using monoclonal antibody H1-229. 21 out of 23 cases (91%) of papillary carcinomas were positively immunostained, whereas none of the 4 follicular carcinomas showed any immunoreactivity. No correlation was found between the nm23-H1/NDP kinase antigen expression and nodal involvement or distant metastasis in primary tumors. However, only 50% (4 out of 8) of metastatic lymph nodes from papillary carcinoma were positively stained, demonstrating a significant decrease comparing to those of primary sites. These data indicate that the expression of nm23-H1/NDP kinase cannot predict tumor metastatic potential in childhood thyroid cancer.
authors: NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 1,NAGASAKI 852,JAPAN. NAGASAKI UNIV,SCH MED,DEPT PATHOL 2,NAGASAKI 852,JAPAN. ITO HOSP,SHIBUYA KU,TOKYO 150,JAPAN.
authors: Y
authors: Y
authors: Shirahige
authors: J
authors: J
authors: Irie
authors: K
authors: K
authors: Ashizawa
authors: N
authors: N
authors: Yokoyama
authors: N
authors: N
authors: Ishikawa
authors: T
authors: T
authors: Mimura
authors: K
authors: K
authors: Ito
authors: S
authors: S
authors: Nagataki