title: Treatment of T cell lymphoblastic lymphoma in children and adolescents: Israel Society of Pediatric Hematology Oncology retrospective study.
abstract: BACKGROUND
  Survival in T cell lymphoblastic lymphoma has improved over the past 30 years, largely due to treatment protocols derived from regimens designed for children with acute lymphoblastic leukemia.
  
  
  OBJECTIVE
  To assess the outcome of the NHL-BFM-95 protocol in children and adolescents hospitalized during the period 1999-2006.
  
  
  METHODS
  We conducted a retrospective multi-institutional, non-randomized study of children and adolescents up to age 21 with T cell lymphoma admitted to pediatric departments in six hospitals in Israel, with regard to prevalence, clinical characteristics, pathological characteristics, prognostic factors, overall survival (OS) and event-free survival (EFS). All patients had a minimal follow-up of one year after diagnosis. The study was based on the NHL-BFM-95 protocol.
  
  
  RESULTS
  At a median follow-up of 4 years (range 1-9 years), OS and EFS for all patients was 86.5% and 83.8%, respectively. OS was 86.7% and 83.3% for patients with stage III and stage IV, respectively, and EFS was 83.3% and 83.3%, respectively. EFS was 62.5% for Arab patients and 89.7% for Jewish patients (P = 0.014). Patients who did not express CD45 antigen showed superior survival (P = 0.028). Five patients (13.5%) relapsed, four of whom died of their disease. Death as a consequence of therapy toxicity was documented in one patient while on the re-induction protocol (protocol IIA).
  
  
  CONCLUSIONS
  Our study shows that OS and EFS for all patients was 86.5% and 83.8%, respectively.
authors: Department of Pediatric Hematology-OncologyMeyer Children's Hospital, Rambam Health Care Campus affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors: Ofrat Beyar
authors: OB
authors: Katz
authors: Ayelet
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authors: Ben Barak
authors: Gall
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authors: Abrahami
authors: Nira
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authors: Arad
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authors: Burstein
authors: Rina
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authors: Dvir
authors: Salvador
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authors: Fischer
authors: Joseph
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authors: Kapelushnik
authors: Haim
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authors: Kaplinsky
authors: Amos
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authors: Toren
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authors: Vilk-Revel
authors: Michael
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authors: Weintraub
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authors: Yaniv
authors: Shai
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authors: Linn
authors: Boris
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authors: Futerman
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authors: Ben-Arush