title: Diastereoselective synthesis of the Leu-Pro type phosphinyl dipeptide isostere.
abstract: A diastereoselective synthesis of the Leu-Pro type phosphinyl dipeptide isostere in its protected form was achieved from stereodefined α-amino-H-phosphinate. The methodology involved a cross-coupling reaction with alkenyl triflate and subsequent diastereoselective hydrogenation of the alkene moiety, which capitalized on the phosphorus chirality.
authors: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors: Takehiro
authors: T
authors: Yamagishi
authors: Naoko
authors: N
authors: Tashiro
authors: Tsutomu
authors: T
authors: Yokomatsu