title: A new paradigm in the treatment of the cardiovascular disease continuum: focus on prevention.
abstract: The cardiovascular disease continuum (CVDC) is a sequence of cardiovascular events, which begins from a cluster of cardiovascular risk factors consisting of diabetes mellitus, dyslipidemia, hypertension, smoking and visceral obesity. If these factors are not intervened with early, they will, inexorably, progress to atherosclerosis, coronary artery disease, myocardial infarction, left ventricular hypertrophy, left ventricular dilatation leading to left ventricular diastolic or systolic dysfunction and eventually end stage heart failure and death. For this concise review, a Medline search of the English language literature between the years 2000 and 2009 was conducted and 33 pertinent publications were selected. Based on the evidence contained in these publications, it is possible that early intervention and treatment of the various cardiovascular risk factors, which initiate and perpetuate the CVDC, could prevent it or arrest its further progress. Therefore, this concise review will emphasize the early detection and treatment of the various cardiovascular risk factors, which initiate and perpetuate the CVDC.
authors: Oklahoma Cardiovascular and Hypertension Center, Oklahoma City, Oklahoma, USA.
authors: S G
authors: SG
authors: Chrysant
references: Diabetes Care. 2007 Jan;30(1):162-72
references: 17192355
references: Circulation. 2004 Jul 13;110(2):227-39
references: 15249516
references: JAMA. 2002 Oct 9;288(14):1723-7
references: 12365955
references: Ann Intern Med. 2003 Jan 7;138(1):10-6
references: 12513039
references: BMJ. 2004 Jun 26;328(7455):1519
references: 15213107
references: N Engl J Med. 2005 Apr 7;352(14):1425-35
references: 15755765
references: Lancet. 2002 Mar 23;359(9311):995-1003
references: 11937178
references: Eur Heart J. 1999 Dec;20(24):1773-82
references: 10581135
references: J Am Coll Cardiol. 2009 Dec 29;55(1):35-41
references: 20117361
references: J Am Coll Cardiol. 2009 Dec 15;54(25):2353-7
references: 20082922
references: Circulation. 2007 Feb 6;115(5):e69-171
references: 17194875
references: Circulation. 2004 Jun 29;109(25):3244-55
references: 15198946
references: Stroke. 2003 Jul;34(7):1586-92
references: 12775882
references: J Am Coll Cardiol. 2009 Mar 10;53(10):860-9
references: 19264243
references: JAMA. 2003 Jul 2;290(1):86-97
references: 12837716
references: Circulation. 2008 Jul 22;118(4):428-64
references: 18591433
references: Eur J Cardiovasc Prev Rehabil. 2008 Feb;15(1):89-94
references: 18277192
references: Lancet. 2002 Jun 15;359(9323):2072-7
references: 12086760
references: Ann N Y Acad Sci. 2006 Nov;1084:1-29
references: 17151290
references: Am J Cardiol. 1976 Jul;38(1):46-51
references: 132862
references: J Am Coll Cardiol. 2009 Dec 15;54(25):2382-7
references: 20082928
references: Circulation. 2007 Jan 30;115(4):459-67
references: 17242284
references: N Engl J Med. 1998 Jul 23;339(4):229-34
references: 9673301
references: J Hum Hypertens. 2009 Jun;23(6):363-84
references: 19110538
references: J Hypertens. 2002 Nov;20(11):2293-300
references: 12409969
references: Circulation. 1999 Sep 28;100(13):1481-92
references: 10500053
references: Lancet. 2002 Dec 14;360(9349):1903-13
references: 12493255
references: Arch Intern Med. 2000 Apr 10;160(7):939-44
references: 10761958
references: J Am Coll Cardiol. 2004 May 19;43(10):1731-7
references: 15145091
references: J Hypertens. 2008 Jul;26(7):1477-86
references: 18551026
references: Circulation. 2009 Feb 3;119(4):530-7
references: 19153265
references: N Engl J Med. 2006 Apr 20;354(16):1685-97
references: 16537662
references: J Hypertens. 2008 Jun;26(6):1049-57
references: 18475139
references: Hypertens Res. 2005 May;28(5):385-407
references: 16156503
references: Diabetes Res Clin Pract. 2005 Feb;67(2):152-62
references: 15649575
references: Circulation. 2006 Dec 19;114(25):2850-70
references: 17179034
references: Circulation. 2006 Feb 14;113(6):898-918
references: 16380542
references: J Am Coll Cardiol. 1996 Apr;27(5):1214-8
references: 8609345
references: J Hypertens. 2008 Jul;26(7):1487-96
references: 18551027