title: High intensity focused ultrasound in clinical tumor ablation.
abstract: Recent advances in high intensity focused ultrasound (HIFU), which was developed in the 1940s as a viable thermal tissue ablation approach, have increased its popularity. In clinics, HIFU has been applied to treat a variety of solid malignant tumors in a well-defined volume, including the pancreas, liver, prostate, breast, uterine fibroids, and soft-tissue sarcomas. In comparison to conventional tumor/cancer treatment modalities, such as open surgery, radio- and chemo-therapy, HIFU has the advantages of non-invasion, non-ionization, and fewer complications after treatment. Over 100 000 cases have been treated throughout the world with great success. The fundamental principles of HIFU ablation are coagulative thermal necrosis due to the absorption of ultrasound energy during transmission in tissue and the induced cavitation damage. This paper reviews the clinical outcomes of HIFU ablation for applicable cancers, and then summarizes the recommendations for a satisfactory HIFU treatment according to clinical experience. In addition, the current challenges in HIFU for engineers and physicians are also included. More recent horizons have broadened the application of HIFU in tumor treatment, such as HIFU-mediated drug delivery, vessel occlusion, and soft tissue erosion ("histotripsy"). In summary, HIFU is likely to play a significant role in the future oncology practice.
authors: Yu-Feng Zhou, Division of Engineering Mechanics, School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
authors: Yu-Feng
authors: YF
authors: Zhou
references: Radiology. 2005 Sep;236(3):1034-40
references: 16055692
references: Urology. 2004 Feb;63(2):297-300
references: 14972475
references: J Endourol. 2005 Jul-Aug;19(6):693-701
references: 16053358
references: Ultrasound Med Biol. 1994;20(3):259-69
references: 8059487
references: J Endourol. 2003 Oct;17(8):673-7
references: 14622488
references: Ultrasound Med Biol. 2004 Sep;30(9):1217-22
references: 15550325
references: Radiology. 2005 May;235(2):659-67
references: 15858105
references: AJR Am J Roentgenol. 2010 Jan;194(1):274-80
references: 20028933
references: Top Magn Reson Imaging. 2006 Jun;17(3):173-9
references: 17414074
references: Lancet. 2001 Jan 27;357(9252):293-8
references: 11214143
references: IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Aug;53(8):1412-24
references: 16921893
references: Eur J Ultrasound. 1999 Mar;9(1):11-8
references: 10099162
references: J Urol. 2006 Feb;175(2):734-8
references: 16407041
references: J Acoust Soc Am. 2008 Jul;124(1):674-9
references: 18647009
references: Eur Urol. 2000 Jun;37(6):687-94
references: 10828669
references: Magn Reson Med. 1996 Nov;36(5):745-52
references: 8916025
references: Arch Surg. 1991 Aug;126(8):1002-9; discussion 1009-10
references: 1863205
references: J Acoust Soc Am. 2005 Jan;117(1):424-35
references: 15704435
references: Int J Hyperthermia. 1994 Jul-Aug;10(4):457-83
references: 7963805
references: Zhonghua Zhong Liu Za Zhi. 2002 Nov;24(6):612-5
references: 12667339
references: Int J Cancer. 1993 Jun 19;54(4):594-606
references: 8514451
references: J Endourol. 2000 Aug;14(6):519-28
references: 10954310
references: Urology. 1998 Jul;52(1):66-71
references: 9671873
references: Ultrasound Med Biol. 1994;20(3):271-7
references: 8059488
references: CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
references: 19474385
references: Curr Urol Rep. 2003 Jun;4(3):248-52
references: 12756090
references: J Urol. 2004 Jun;171(6 Pt 1):2265-7
references: 15126799
references: Ultrasound Obstet Gynecol. 2009 Nov;34(5):584-9
references: 19852041
references: Ultrasound Med Biol. 2007 Oct;33(10):1592-8
references: 17618040
references: Br J Radiol. 2004 Sep;77(921):713-23
references: 15447955
references: Br J Urol. 1997 Feb;79(2):172-6
references: 9052465
references: Ultrasound Med Biol. 2005 Nov;31(11):1539-50
references: 16286031
references: Neuroimage. 2005 Jan 1;24(1):12-20
references: 15588592
references: Ultrasound Med Biol. 2006 Jan;32(1):115-29
references: 16364803
references: Urology. 1999 Aug;54(2):273-7
references: 10443724
references: Am J Med. 2001 May;110(7):558-62
references: 11343669
references: Nat Clin Pract Urol. 2005 Apr;2(4):191-8
references: 16474762
references: J Urol. 2003 Dec;170(6 Pt 1):2237-40
references: 14634387
references: Obstet Gynecol. 2002 Feb;99(2):290-300
references: 11814511
references: Nat Rev Cancer. 2005 Apr;5(4):321-7
references: 15776004
references: Breast Cancer Res Treat. 2005 Jul;92(1):51-60
references: 15980991
references: Mol Urol. 2000 Fall;4(3):179-82
references: 11062372
references: Ultrasonics. 2001 Jun;39(4):307-9
references: 11432441
references: Science. 1955 Sep 16;122(3168):517-8
references: 13255886
references: Exp Hematol. 2002 Nov;30(11):1293-301
references: 12423682
references: Radiographics. 1996 Jan;16(1):185-95
references: 10946699
references: Int J Hyperthermia. 2005 Dec;21(8):745-53
references: 16338857
references: Ultrasound Med Biol. 1995;21(1):113-9
references: 7754571
references: Zhonghua Zhong Liu Za Zhi. 2002 May;24(3):278-81
references: 12515626
references: IEEE Trans Ultrason Ferroelectr Freq Control. 1988;35(5):578-81
references: 18290190
references: Eur Urol. 1996;29(2):174-83
references: 8647143
references: Med Eng Phys. 2000 May;22(4):253-63
references: 11018457
references: Int J Hyperthermia. 2007 Mar;23(2):89-104
references: 17578335
references: Eur J Radiol. 2006 Aug;59(2):163-7
references: 16740371
references: Expert Opin Drug Deliv. 2004 Nov;1(1):37-56
references: 16296719
references: Ultrasound Med Biol. 2001 Aug;27(8):1099-106
references: 11527596
references: J Acoust Soc Am. 2007 Mar;121(3):1434-9
references: 17407880
references: Eur Urol. 1993;23 Suppl 1:44-7
references: 7685696
references: Top Magn Reson Imaging. 2006 Jun;17(3):209-15
references: 17414078
references: Phys Med Biol. 2009 May 7;54(9):2597-613
references: 19351986
references: Fertil Steril. 2006 Jan;85(1):22-9
references: 16412721
references: J Transl Med. 2007 Jul 11;5:34
references: 17625013
references: World J Urol. 2006 Nov;24(5):585-90
references: 16850340
references: Ultrasound Med Biol. 2008 Mar;34(3):406-13
references: 17988788
references: Adv Exp Med Biol. 1990;267:369-81
references: 2088054
references: Phys Med Biol. 2006 Feb 21;51(4):793-807
references: 16467579
references: Arch Surg. 1973 Dec;107(6):887-91
references: 4751833
references: Breast Cancer. 2007;14(1):55-8
references: 17244995
references: Ultrasound Obstet Gynecol. 2004 Mar;23(3):216-7
references: 15027006
references: Invest Radiol. 1990 Jul;25(7):824-34
references: 2202694
references: J Acoust Soc Am. 2007 Apr;121(4):2421-30
references: 17471753
references: Ann Surg Oncol. 2009 Jan;16(1):140-6
references: 19002530
references: World J Gastroenterol. 2004 Aug 1;10(15):2201-4
references: 15259065
references: Ultrasound Med Biol. 1978;4(4):337-41
references: 753007
references: Radiology. 2005 Feb;234(2):431-7
references: 15671000
references: J Magn Reson Imaging. 2008 Feb;27(2):391-9
references: 18219674
references: J Acoust Soc Am. 2006 Aug;120(2):676-85
references: 16938956
references: Radiology. 2001 Sep;220(3):640-6
references: 11526261
references: Ultrasound Med Biol. 2005 Nov;31(11):1527-37
references: 16286030
references: Semin Urol. 1993 Feb;11(1):7-9
references: 7682004
references: Prostate Cancer Prostatic Dis. 2006;9(4):439-43
references: 16847468
references: Ultrasonics. 2006 Dec 22;44 Suppl 1:e31-5
references: 16844165
references: J Clin Ultrasound. 1998 Feb;26(2):59-64
references: 9460631
references: Am J Pathol. 1944 May;20(3):637-49
references: 19970769
references: Ultrasound Med Biol. 2001 Oct;27(10):1427-33
references: 11731056
references: Int J Urol. 2006 Mar;13(3):228-33
references: 16643614
references: J Acoust Soc Am. 2009 Apr;125(4):2420-31
references: 19354416
references: AJR Am J Roentgenol. 2008 Jan;190(1):191-9
references: 18094311
references: Expert Rev Med Devices. 2010 May;7(3):303-6
references: 20420552
references: NMR Biomed. 2008 Oct;21(8):849-58
references: 18574794
references: Phys Med Biol. 1991 Nov;36(11):1495-501
references: 1754620
references: Cancer Res. 1995 Aug 1;55(15):3346-51
references: 7542168
references: J Gen Physiol. 1942 Nov 20;26(2):179-93
references: 19873337