title: Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata.
abstract: Bioassay-guided isolation was performed on the leaves of Apodytes dimidiata E. Mey. Ex Arn. (Icacinaceae), based on previously demonstrated activity against Leishmania. Six saponins never isolated from nature before were elucidated with LC-MS/MS, GC-MS and 1D and 2D NMR. The compounds apodytine A-F are responsible at least in part for the antiprotozoal activity, but also possess haemolytic activity and display antiangiogenic activity in the rat aorta ring assay, an effect which may be due to a non-selective toxicity.
authors: Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. Kenn.Foubert@ua.ac.be
authors: Kenn
authors: K
authors: Foubert
authors: Filip
authors: F
authors: Cuyckens
authors: Ann
authors: A
authors: Matheeussen
authors: Arnold
authors: A
authors: Vlietinck
authors: Sandra
authors: S
authors: Apers
authors: Louis
authors: L
authors: Maes
authors: Luc
authors: L
authors: Pieters