title: Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brain.
abstract: Lipin-1 proteins are phosphatidic acid phosphatases (PAPs) catalyzing the conversion from phosphatidic acid (PA) to diacylglycerol (DG). Two alternative splicing isoforms, lipin-1α and -1β, are localized at different subcellular compartments. A third splicing isoform, lipin-1γ was recently cloned and its subcellular localization is unknown. Here, we demonstrate that lipin-1γ is localized to lipid droplets (LDs), an association mediated by a hydrophobic, lipin-1γ-specific domain. Additional expression of lipin-1γ altered LD morphology without affecting the triacylglycerol (TG) level. In human tissues, lipin-1γ is the main lipin-1 isoform expressed in normal human brain, suggesting a specialized role in regulating brain lipid metabolism.
authors: Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. huajin.wnag@yale.edu
authors: Huajin
authors: H
authors: Wang
authors: Jing
authors: J
authors: Zhang
authors: Wei
authors: W
authors: Qiu
authors: Gil-Soo
authors: GS
authors: Han
authors: George M
authors: GM
authors: Carman
authors: Khosrow
authors: K
authors: Adeli
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