title: Effect of specific activity on neuroblastoma uptake of I-123-meta-iodobenzylguanidine in nude mice xenografted with SK-N-SH cells.
abstract: The effect of specific activity of meta[I-123]iodobenzylguanidine ([I-123]MIBG) on neuroblastoma uptake was studied in a nude mouse model (NMRI nu/nu) xenografted subcutaneously with SK-N-SH cells. Groups of eight animals received [I-123]MIBG intravenously with a specific activity of greater than or equal to 260 GBq/mu mol (no-carrier-added), 3.7 GBq/mu mol, 37 MBq/mu mol, and 0.37 MBq/mu mol, respectively. All animals in the group injected with 0.37 MBq/mu mol died immediately after the injection. Al 4 and 24 h, there was no significant effect of specific activity on tumor uptake of [I-123]MIBG in the different groups. The uptake of non-tumor tissue was in general lower with 37 MBq/mu mol compared to higher specific activities. The differences in blood, heart, liver, spleen and lungs were statistically significant at 24 h, whereas at 4 h significant differences were only present in the heart, liver and lungs. The results suggest that for the treatment of children with neuroblastoma a lower specific activity of radioiodinated MIBG may minimize the radiation exposure to non-tumor tissue but not to the tumor. Higher mass of MIBG >0.5 mu mol/g, however, is considered as lethal dose in our nude mice model and corresponding doses may cause toxic side effects in human.
authors: UNIV ESSEN GESAMTHSCH,DEPT NUCL MED,ESSEN,GERMANY. UNIV ESSEN GESAMTHSCH,DEPT RADIAT ONCOL,ESSEN,GERMANY. UNIV ESSEN GESAMTHSCH,DEPT PEDIAT ONCOL,ESSEN,GERMANY.
authors: J
authors: J
authors: Farahati
authors: H
authors: H
authors: Coenen
authors: K
authors: K
authors: Dutschka
authors: G
authors: G
authors: Stuben
authors: K
authors: K
authors: Knuhmann
authors: W
authors: W
authors: Budach
authors: B
authors: B
authors: Kremens
authors: C
authors: C
authors: Reiners