title: Total and regional brain volumes in a population-based normative sample from 4 to 18 years: the NIH MRI Study of Normal Brain Development.
abstract: Using a population-based sampling strategy, the National Institutes of Health (NIH) Magnetic Resonance Imaging Study of Normal Brain Development compiled a longitudinal normative reference database of neuroimaging and correlated clinical/behavioral data from a demographically representative sample of healthy children and adolescents aged newborn through early adulthood. The present paper reports brain volume data for 325 children, ages 4.5-18 years, from the first cross-sectional time point. Measures included volumes of whole-brain gray matter (GM) and white matter (WM), left and right lateral ventricles, frontal, temporal, parietal and occipital lobe GM and WM, subcortical GM (thalamus, caudate, putamen, and globus pallidus), cerebellum, and brainstem. Associations with cross-sectional age, sex, family income, parental education, and body mass index (BMI) were evaluated. Key observations are: 1) age-related decreases in lobar GM most prominent in parietal and occipital cortex; 2) age-related increases in lobar WM, greatest in occipital, followed by the temporal lobe; 3) age-related trajectories predominantly curvilinear in females, but linear in males; and 4) small systematic associations of brain tissue volumes with BMI but not with IQ, family income, or parental education. These findings constitute a normative reference on regional brain volumes in children and adolescents.
references: Biol Psychiatry. 2007 Jun 15;61(12):1361-9
references: 16950217
references: Exp Brain Res. 2007 Apr;178(3):296-307
references: 17051378
references: Nat Neurosci. 1999 Oct;2(10):861-3
references: 10491603
references: J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205
references: 8126267
references: Arch Gen Psychiatry. 1994 Jan;51(1):8-19
references: 8279933
references: Dev Neuropsychol. 2010;35(3):296-317
references: 20446134
references: J Neurosci. 2010 Mar 24;30(12):4419-27
references: 20335478
references: Neuroimage. 2005 Feb 1;24(3):678-91
references: 15652303
references: Cereb Cortex. 1998 Jun;8(4):372-84
references: 9651132
references: Neuroimage. 2006 Jul 15;31(4):1419-25
references: 16545583
references: Am J Psychiatry. 2003 Dec;160(12):2181-9
references: 14638588
references: Med Image Anal. 2003 Dec;7(4):513-27
references: 14561555
references: J Magn Reson Imaging. 2008 Aug;28(2):308-19
references: 18666143
references: Obesity (Silver Spring). 2008 Jan;16(1):119-24
references: 18223623
references: Int J Neurosci. 2008 Nov;118(11):1582-93
references: 18853335
references: Ann N Y Acad Sci. 1976;280:349-66
references: 827951
references: IEEE Trans Med Imaging. 2002 Oct;21(10):1280-91
references: 12585710
references: J Comp Neurol. 1997 Oct 20;387(2):167-78
references: 9336221
references: Arch Pediatr Adolesc Med. 2010 Jul;164(7):598-607
references: 20603458
references: IEEE Trans Med Imaging. 1998 Feb;17(1):87-97
references: 9617910
references: Trends Cogn Sci. 2009 Feb;13(2):65-73
references: 19135405
references: Neuroimage. 2007 Mar;35(1):308-25
references: 17239623
references: J Child Neurol. 2006 Nov;21(11):922-31
references: 17092456
references: Brain Cogn. 1999 Aug;40(3):441-52
references: 10415130
references: Neuroimage. 2006 Mar;30(1):184-202
references: 16376577
references: J Am Acad Child Adolesc Psychiatry. 1997 Feb;36(2):282-90
references: 9031582
references: Trends Cogn Sci. 2010 Mar;14(3):138-46
references: 20138795
references: Hum Brain Mapp. 2010 Jul;31(7):1052-64
references: 19998366
references: Neuroimage. 2008 Apr 15;40(3):1392-401
references: 18308588
references: N Engl J Med. 2008 Jun 5;358(23):2468-81
references: 18525043
references: Psychiatry Res. 1997 Mar 14;74(1):1-12
references: 10710158
references: Cereb Cortex. 2007 Jul;17(7):1550-60
references: 16945978
references: Biometrics. 1982 Dec;38(4):963-74
references: 7168798
references: Hum Brain Mapp. 2002 Nov;17(3):143-55
references: 12391568
references: Neuroimage. 2007 Jul 15;36(4):1065-73
references: 17513132
references: Cereb Cortex. 1996 Sep-Oct;6(5):726-36
references: 8921207
references: Cereb Cortex. 1996 Jul-Aug;6(4):551-60
references: 8670681
references: Soc Sci Med. 1998 Dec;47(12):2043-53
references: 10075245
references: Brain Cogn. 2000 Mar;42(2):183-200
references: 10744919
references: Biol Psychiatry. 2007 Oct 15;62(8):847-55
references: 17544382
references: Biometrics. 2005 Dec;61(4):1037-48
references: 16401277
references: J Neurosci. 2007 Feb 7;27(6):1255-60
references: 17287499
references: Schizophr Res. 1999 Nov 30;40(2):111-20
references: 10593451
references: J Int Neuropsychol Soc. 2007 Sep;13(5):729-46
references: 17511896
references: Hum Brain Mapp. 2003 Jun;19(2):79-89
references: 12768532
references: Dev Med Child Neurol. 2002 Jan;44(1):4-16
references: 11811649
references: Oncogene. 2002 Oct 21;21(48):7326-40
references: 12379876
references: Autism Res. 2010 Dec;3(6):350-8
references: 21182212
references: Neuroreport. 2002 Dec 3;13(17):2371-4
references: 12488829
references: Neuroreport. 2001 Mar 5;12(3):515-23
references: 11234756
references: Radiology. 1989 Aug;172(2):549-54
references: 2748838
references: Brain. 1996 Oct;119 ( Pt 5):1763-74
references: 8931596
references: J Clin Endocrinol Metab. 2007 Aug;92(8):3278-84
references: 17536002
references: Annu Rev Public Health. 2002;23:303-31
references: 11910065
references: Child Dev. 2001 Jul-Aug;72(4):988-1002
references: 11480950