title: Relationship between Metabolic Syndrome and MTHFR Polymorphism in Colorectal Cancer.
abstract: OBJECTIVE
  There have been studies on the relations between metabolic syndrome and colorectal cancer or on the relations between methylenetetrahydrofolate reductase (MTHFR) polymorphism and colorectal cancer, but reports on the relationship between metabolic syndrome, MTHFR polymorphism and colorectal cancer all together are rare. The aim of this study is to find the interrelation between metabolic syndrome and MTHFR polymorphism in colorectal cancer.
  
  
  METHODS
  This study investigated 255 colorectal cancer patients (cancer group) who underwent surgery in our hospital from March 2003 to December 2008 and compared those patients to 488 healthy patients (control group). The diagnostic criterion for metabolic syndrome was based on the National Cholesterol Education Program-Adult Treatment Panel III (NCEP ATP III), and the MTHFR 677 polymorphism was analyzed.
  
  
  RESULTS
  When colorectal cancer patients and patients in the control group were classified as MTHFR 677 subtypes, there was no difference between the two groups: CC 87 (34.1%), CT 134 (52.6%), and TT 34 (13.3%) for the cancer group and CC 145 (32.4%), CT 238 (53.1%), and TT 65 (14.5%) for the control group. Distributions of MTHFR 677C/T genotype and allele frequencies in the individuals with and without metabolic syndrome in the cancer group showed no differences. Moreover, we could find no differences in distributions of MTHFR 677C/T genotypes in the clinical and the biomedical variables of individuals with and without metabolic syndrome in the cancer group.
  
  
  CONCLUSIONS
  Our results show no relation between metabolic syndrome and MTHFR polymorphism in colorectal cancer. However, a further prospective study, based on a precise diagnostic criterion for metabolic syndrome, is needed.
authors: Department of Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
authors: Bong Su
authors: BS
authors: Kang
authors: Dae Ho
authors: DH
authors: Ahn
authors: Nam Keun
authors: NK
authors: Kim
authors: Jong Woo
authors: JW
authors: Kim
references: Gut. 2006 Feb;55(2):285-91
references: 16239255
references: Int J Colorectal Dis. 2007 May;22(5):483-9
references: 16941173
references: Gut. 2002 Apr;50(4):520-4
references: 11889073
references: Metabolism. 2003 Nov;52(11):1491-5
references: 14624412
references: Circulation. 2003 Sep 30;108(13):1546-51
references: 14517150
references: Schizophr Res. 2008 Jan;98(1-3):47-54
references: 17976958
references: Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2391-7
references: 17164361
references: Nature. 1998 Dec 17;396(6712):643-9
references: 9872311
references: Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2023-9
references: 16103455
references: Diabetes Metab Rev. 1988 Nov;4(7):639-52
references: 3069396
references: Diabetologia. 2003 May;46(5):595-607
references: 12764580