title: Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity.
abstract: Carbon nanotubes (CNTs) cause perturbations in immune systems and limit the application of CNTs in biomedicine. Here we demonstrate that a surface chemistry modification on multiwalled CNTs (MWCNTs) reduces their immune perturbations in mice and in macrophages. The modified MWCNTs change their preferred binding pattern from mannose receptor to scavenger receptor. This switch significantly alleviates NFκB activation and reduces immunotoxicity of MWCNTs.
authors: School of Pharmaceutical Sciences, Shandong University, Jinan 250100, China.
authors: Ningning
authors: N
authors: Gao
authors: Qiu
authors: Q
authors: Zhang
authors: Qingxin
authors: Q
authors: Mu
authors: Yuhong
authors: Y
authors: Bai
authors: Liwen
authors: L
authors: Li
authors: Hongyu
authors: H
authors: Zhou
authors: Elizabeth R
authors: ER
authors: Butch
authors: Tremaine B
authors: TB
authors: Powell
authors: Scott E
authors: SE
authors: Snyder
authors: Guibin
authors: G
authors: Jiang
authors: Bing
authors: B
authors: Yan
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