title: Distinct spectrum of N-ras mutations in aml and mds patients in yugoslavia.
abstract: Mutations that activate ras genes were demonstrated to be associated with certain types of malignancies. Multiple point mutations were predominantly found in the N-ras and occasionally in the K-ras genes. The analysis of 4 MDS, 23 AML and 11 CML patients from Yugoslavia revealed the prevalence of the N-ras mutation (83%) over K-ras mutations (17%). Although the frequencies of the N- and K-ras mutations in these patients were similar to the ones reported for patients from USA and Japan, the N-ras mutational spectra considerably differed. The prevailing type of mutation in patients from Yugoslavia was G-to-T transversion at the first position in the codon 12 of the N-ras gene. This study supports a hypothesis that different geographical and environmental factors may cause the accumulation of different type of point mutations in the same target gene.
authors: INST MED RES,YU-11001 BELGRADE,YUGOSLAVIA. MIL MED ACAD,HEMATOL CLIN,BELGRADE,YUGOSLAVIA.
authors: K
authors: K
authors: Krtolica
authors: N
authors: N
authors: Urosevic
authors: D
authors: D
authors: Nesic
authors: L
authors: L
authors: Tukic
authors: B
authors: B
authors: Dimitrijevic
authors: A
authors: A
authors: Dujic