title: Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): central amino acid linker and right-hand-side SAR studies.
abstract: In this part 2, new indole 5-carboxamide Thumb Pocket 1 inhibitors of HCV NS5B polymerase are described. Structure-activity relationships (SAR) were explored at the central amino acid linker position and the right-hand-side of the molecule in an attempt to identify molecules with a balanced overall profile of potency (EC(50)<100 nM), physicochemical properties and ADME characteristics.
authors: Department of Chemistry, Boehringer Ingelheim (Canada) Ltd, Research and Development, Laval, Québec, Canada. pierre.beaulieu@boehringer-ingelheim.com
authors: Pierre L
authors: PL
authors: Beaulieu
authors: Catherine
authors: C
authors: Chabot
authors: Jianmin
authors: J
authors: Duan
authors: Michel
authors: M
authors: Garneau
authors: James
authors: J
authors: Gillard
authors: Eric
authors: E
authors: Jolicoeur
authors: Martin
authors: M
authors: Poirier
authors: Marc-André
authors: MA
authors: Poupart
authors: Timothy A
authors: TA
authors: Stammers
authors: George
authors: G
authors: Kukolj
authors: Youla S
authors: YS
authors: Tsantrizos