title: Therapeutic interventions targeting organ preservation in muscle-invasive bladder cancer: a review.
abstract: Nowadays in modern oncology there is a tendency towards therapies that target organ preservation. Organ preservation protocols have become standard in the treatment of laryngeal carcinoma, oesophageal cancer, breast carcinoma and soft tissue sarcomas. The three-combined therapy consisting of a transurethral resection of the bladder tumour followed by concomitant chemoradiotherapy has been shown to be an attractive alternative for bladder preservation in selected patients with muscle-invasive bladder cancer. In order to evaluate the organ preservation approaches in muscle-invasive bladder cancer we have conducted a comprehensive literature review. Data reported from the studies have shown that bladder preservation therapy with a trimodality approach is safe and effective. Moreover, such an approach provides patients with the opportunity to maintain an intact and functional bladder with a survival rate similar to that of radical cystectomy.
authors: Second Radiation Therapy Department, Anticancer Institute of Athens Saint Savvas, Athens, Greece. gkoyokoyrakis@yahoo.gr
authors: Georgios
authors: G
authors: Koukourakis
authors: Vassilios
authors: V
authors: Kouloulias
authors: Georgios
authors: G
authors: Zacharias
authors: Anastasia
authors: A
authors: Sotiropoulou-Lontou
authors: Michael
authors: M
authors: Koukourakis
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