title: Establishment and characterization of a new cell line derived from a human chondrosarcoma.
abstract: A new human cell line, CAL 78, derived from a dedifferentiated chondrosarcoma of the muscle of the thigh has been established in culture. Fibroblastoid morphology, vimentin expression and lack of epithelial antigens are in agreement with mesodermic origin of these cells. The xenograft of CAL 78 cells in nude mouse showed the characteristics of hyaline cartilaginous differentiation. Cytogenetic changes were numerous and complex, all the metaphases were tetraploid and no alterations described by other authors have been found. CAL 78 constitutes an appropriate model to evaluate efficiency of a new therapy for chondrosarcomas. Moreover, this cell line may be used to study some stage of chondrocytic differentiation.
authors: CTR ANTOINE LACASSAGNE,F-06189 NICE 2,FRANCE. FAC MED NICE,LAB CANCEROL,F-06107 NICE,FRANCE. UNIV NICE SOPHIA ANTIPOLIS,DEPT PHYS,F-06108 NICE 2,FRANCE. LAB GENAZUR,F-06100 NICE,FRANCE.
authors: M
authors: M
authors: Farges
authors: C
authors: C
authors: Mazeau
authors: J
authors: J
authors: Gioanni
authors: F
authors: F
authors: Ettore
authors: H
authors: H
authors: Denovion
authors: M
authors: M
authors: Schneider