title: Reduction of CD4+ T cells in vivo does not affect virus load in macaque elite controllers.
abstract: A small percentage of human immunodeficiency virus (HIV)- and simian immunodeficiency virus (SIV)-infected individuals spontaneously control virus replication. The majority of these elite controllers mount high-frequency virus-specific CD4(+) T cell responses. To evaluate the role these responses might play in viral control, we depleted two elite controller macaques of CD4(+) cells. SIV-specific CD4(+) T cell responses did not return to baseline levels until 8 weeks postdepletion. Viral loads remained stable throughout the experiment, suggesting that SIV-specific CD4(+) T cell responses may not play a direct role in controlling chronic viral replication in these elite controllers.
authors: Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, 555 Science Dr., Madison, WI 53711, USA.
authors: Philip A
authors: PA
authors: Mudd
authors: Adam J
authors: AJ
authors: Ericsen
authors: Andrew A
authors: AA
authors: Price
authors: Nancy A
authors: NA
authors: Wilson
authors: Keith A
authors: KA
authors: Reimann
authors: David I
authors: DI
authors: Watkins
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