title: Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats.
abstract: A gastroprotective effect occurs when α(2) receptors are innervated. The dextro isomer of medetomidine, dexmedetomidine, is a highly selective α(2)-adrenoreceptor agonist. The aim of this study was to investigate whether dexmedetomidine has an antiulcerative effect and to show whether the antiulcer mechanism of dexmedetomidine is linked with oxidant/antioxidant parameters. The antiulcerative effect of dexmedetomidine was studied in an indomethacin-induced ulcer model, and some oxidant/antioxidant parameters were measured in these gastric tissues. Whereas the average ulcerous areas for the groups that received 10, 25, 50, and 100 μg/kg dexmedetomidine doses were 29 ± 4.2, 8 ± 2.1, 0 ± 0 and 0 ± 0 mm(2), respectively, the ulcerous area was 52.1 ± 4.5 mm(2) in the indomethacin control group and 0.5 ± 0.2 mm(2) in the famotidine group. In conclusion, the α(2)-adrenoreceptor agonist dexmedetomidine showed a significant antiulcerative effect in rat gastric tissue at all doses. This antiulcerative effect is stronger with increasing dosage; at the 50 and 100 μg/kg doses, no ulcerous areas were observed. In light of these results, we conclude that there is a correlation between antiulcer mechanisms and α(2)-receptor activation. In rats given dexmedetomidine, all of the investigated antioxidant parameters increased, except for catalase (CAT). Conversely, aside from myeloperoxidase (MPO), all oxidant parameters decreased. Therefore, oxidant/antioxidant parameters play a role in the antiulcer mechanism of dexmedetomidine.
authors: Department of Pharmacology, Faculty of Medicine, Ataturk University, 25240 Erzurum, Turkey.
authors: Beyzagul
authors: B
authors: Polat
authors: Yavuz
authors: Y
authors: Albayrak
authors: Bahadír
authors: B
authors: Suleyman
authors: Hakan
authors: H
authors: Dursun
authors: Fehmi
authors: F
authors: Odabasoglu
authors: Murat
authors: M
authors: Yigiter
authors: Zekai
authors: Z
authors: Halici
authors: Halis
authors: H
authors: Suleyman