title: Immunohistochemical study on cathepsin-B and cathepsin-d in pancreatic-cancer.
abstract: Lysosomal enzymes, cathepsin B and D, have been studied in their possible relationship to the ability of malignant cells to invade and metastasize. In the current investigation, these cathepsins were detected immunohistochemically using avidin-biotin-peroxidase complex method in the pancreatic cancer cells of 21 patients. The positive rate of identification of cathepsin B and D was 43% and 81%, respectively. Cathepsin D stained more strongly than cathepsin B and the plasma membrane stained quite strongly in two instances. A correlation between the presence of cathepsin B or D in cancer cells and the degree of metastasis to lymph nodes, liver, or lung was not recognized.
authors: MED COLL OHIO,DEPT SURG,TOLEDO,OH 43699. MED COLL OHIO,DEPT PATHOL,TOLEDO,OH 43699. TOLEDO HOSP,TOLEDO,OH 43606.
authors: B
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authors: Nakata
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authors: Appert
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authors: Lei
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authors: Yamashita
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authors: Chung
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authors: Sowa
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authors: Myles
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authors: Mao
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authors: Howard