title: Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population.
abstract: Chronic obstructive pulmonary disease (COPD) is a complex human disease influenced by multiple genes and environmental factors. The SERPINE2 gene has recently been demonstrated to be associated with COPD onset in a non-East Asian population. In this study, we genotyped 20 single nucleotide polymorphisms (SNPs) in SERPINE2 from 310 cases and 203 controls, all of which belong to the Han from North China. Genotype frequencies were compared between the cases and the controls and analyzed for statistical significance. Two SNPs (rs729631 and rs975278), which are in strong linkage disequilibrium (LD) and locate in block 1 on the LD map of our samples, showed significant association both with the risk of COPD and decline in baseline lung function after Bonferroni correction (P < 0.05). This study provides further evidences for SERPINE2 gene as a COPD susceptible gene, and block 1 of SERPINE2 appears to be the genetic variant region that affects the Han Chinese.
authors: Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Institute of Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, No 8, Gongren Tiyuchang Nanlu, Chao-yang District, Beijing 100020, China.
authors: Li
authors: L
authors: An
authors: Ting
authors: T
authors: Yang
authors: Yongbiao
authors: Y
authors: Zhang
authors: Yingxiang
authors: Y
authors: Lin
authors: Hong
authors: H
authors: Zhang
authors: Xia
authors: X
authors: Jiao
authors: Lin
authors: L
authors: Hua
authors: Huaping
authors: H
authors: Dai
authors: Chen
authors: C
authors: Wang
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