title: The causes, consequences, and treatment of left or right heart failure.
abstract: Chronic heart failure (HF) is a cardiovascular disease of cardinal importance because of several factors: a) an increasing occurrence due to the aging of the population, primary and secondary prevention of cardiovascular events, and modern advances in therapy, b) a bad prognosis: around 65% of patients are dead within 5 years of diagnosis, c) a high economic cost: HF accounts for 1% to 2% of total health care expenditure. This review focuses on the main causes, consequences in terms of morbidity, mortality and costs and treatment of HF.
authors: Department of Cardiology, Complejo hospitalario Universitario A Coruña, A Coruña, Spain. pablo.pazos.lopez@gmail.com
authors: Pablo
authors: P
authors: Pazos-López
authors: Jesús
authors: J
authors: Peteiro-Vázquez
authors: Ana
authors: A
authors: Carcía-Campos
authors: Lourdes
authors: L
authors: García-Bueno
authors: Juan Pablo Abugattas
authors: JP
authors: de Torres
authors: Alfonso
authors: A
authors: Castro-Beiras
references: J Am Coll Cardiol. 2008 Dec 2;52(23):1834-1843
references: 19038680
references: Cardiovasc Res. 2003 Sep 1;59(3):549-62
references: 14499856
references: N Engl J Med. 2005 Jan 20;352(3):225-37
references: 15659722
references: Circulation. 2006 Mar 21;113(11):1424-33
references: 16534009
references: N Engl J Med. 2006 Jul 20;355(3):251-9
references: 16855265
references: Ann Intern Med. 1987 Mar;106(3):346-54
references: 3028221
references: Circulation. 2008 May 20;117(20):2608-16
references: 18458170
references: Am J Cardiol. 1981 Jan;47(1):33-9
references: 7457405
references: Eur J Heart Fail. 2010 Dec;12(12):1354-62
references: 21098580
references: Circulation. 1995 Apr 1;91(7):2043-8
references: 7895363
references: Lancet. 2004 Jun 5;363(9424):1881-91
references: 15183628
references: Br J Pharmacol. 1992 Apr;105(4):771-2
references: 1324047
references: Lancet. 2000 Feb 19;355(9204):637-45
references: 10696996
references: N Engl J Med. 2001 Nov 15;345(20):1435-43
references: 11794191
references: Ann Thorac Surg. 2004 Sep;78(3):794-9; discussion 794-9
references: 15336993
references: Eur J Heart Fail. 2002 Jun;4(3):361-71
references: 12034163
references: Vasc Health Risk Manag. 2009;5(1):13-9
references: 19436649
references: Circulation. 2006 Aug 1;114(5):397-403
references: 16864724
references: Eur Heart J. 2000 Oct;21(20):1653-65
references: 11032692
references: Eur Heart J. 2005 Jan;26(2):187-92
references: 15618076
references: J Card Fail. 1996 Mar;2(1):47-54
references: 8798105
references: Circulation. 2000 Jun 27;101(25):2981-8
references: 10869273
references: N Engl J Med. 2002 Oct 31;347(18):1397-402
references: 12409541
references: Clin Res Cardiol. 2007 Jul;96(7):481-8
references: 17534568
references: Mayo Clin Proc. 2010 Feb;85(2):180-95
references: 20118395
references: Circulation. 2000 Feb 15;101(6):594-7
references: 10673249
references: Coron Artery Dis. 2004 Aug;15(5):291-7
references: 15238827
references: Circulation. 2008 Jan 29;117(4):526-35
references: 18195176
references: Circulation. 2003 Apr 8;107(13):1719-21
references: 12682028
references: N Engl J Med. 2009 Dec 03;361(23):2241-51
references: 19920051
references: JAMA. 1996 May 22-29;275(20):1557-62
references: 8622246
references: Arch Intern Med. 2001 Apr 9;161(7):996-1002
references: 11295963
references: J Am Coll Cardiol. 2009 Jan 13;53(2):184-92
references: 19130987
references: J Heart Lung Transplant. 2010 Oct;29(10):1089-103
references: 20870164
references: Clin Pharmacol Ther. 1995 Jun;57(6):601-9
references: 7781259
references: J Am Coll Cardiol. 2004 Apr 21;43(8):1432-8
references: 15093880
references: Vasc Health Risk Manag. 2010 Jun 01;6:411-8
references: 20539843
references: N Engl J Med. 1998 Jul 16;339(3):173-81
references: 9664095
references: N Engl J Med. 2003 Apr 3;348(14):1309-21
references: 12668699
references: N Engl J Med. 2010 Dec 9;363(24):2301-9
references: 21080835
references: N Engl J Med. 1991 Aug 1;325(5):303-10
references: 2057035
references: J Am Coll Cardiol. 1995 May;25(6):1239-49
references: 7722116
references: Pacing Clin Electrophysiol. 1996 Jan;19(1):95-106
references: 8848384
references: Heart. 2003 Dec;89(12):1455-61
references: 14617564
references: Vasc Health Risk Manag. 2010 May 06;6:297-305
references: 20479952
references: J Am Coll Cardiol. 2002 Apr 3;39(7):1151-8
references: 11923039
references: Rev Esp Cardiol. 2010 Apr;63(4):451-71
references: 20334811
references: N Engl J Med. 2004 Nov 11;351(20):2049-57
references: 15533851
references: Arch Intern Med. 1996 Sep 9;156(16):1789-96
references: 8790072
references: Circulation. 2006 Jul 18;114(3):216-25
references: 16831987
references: Eur Heart J. 2002 Dec;23(23):1861-6
references: 12445535
references: Eur Heart J. 2008 Jan;29(2):270-6
references: 17916581
references: Ann Intern Med. 2004 Nov 2;141(9):693-704
references: 15520426
references: Circulation. 1998 Jan 27;97(3):282-9
references: 9462531
references: J Am Coll Cardiol. 1985 Apr;5(4):869-74
references: 3156176
references: N Engl J Med. 1999 Sep 2;341(10):709-17
references: 10471456
references: Heart. 2000 May;83(5):505-10
references: 10768897
references: Eur Heart J. 2004 Sep;25(18):1614-9
references: 15351160
references: Heart. 2003 Jun;89(6):615-20
references: 12748214
references: Eur J Heart Fail. 2009 May;11(5):433-43
references: 19386813
references: Circulation. 2004 Jun 22;109(24):2959-64
references: 15210613
references: Eur Heart J. 2005 Feb;26(3):215-25
references: 15642700
references: Am Heart J. 2007 Jun;153(6):1021-8
references: 17540205
references: J Am Coll Cardiol. 2009 Nov 10;54(20):1837-46
references: 19800193
references: N Engl J Med. 2009 Apr 23;360(17):1705-17
references: 19329820
references: N Engl J Med. 2007 Dec 13;357(24):2461-71
references: 17986493
references: JAMA. 2007 Jun 13;297(22):2502-14
references: 17565085
references: J Am Coll Cardiol. 2006 Sep 5;48(5):e247-346
references: 16949478
references: Int J Cardiol. 2005 Oct 20;105(1):46-52
references: 16207544
references: Circulation. 1987 Jan;75(1 Pt 2):I19-25
references: 2947748
references: Lancet. 2010 Sep 11;376(9744):886-94
references: 20801495
references: J Pharmacol Exp Ther. 1989 Mar;248(3):1175-81
references: 2703968
references: Cardiovasc Res. 1999 Jul;43(1):77-85
references: 10536692
references: JAMA. 2004 Jul 21;292(3):344-50
references: 15265849
references: Circulation. 2002 Oct 22;106(17):2194-9
references: 12390947
references: Eur Heart J. 1998 Mar;19(3):481-9
references: 9568453
references: Circulation. 1983 Oct;68(4):803-12
references: 6352079
references: Am J Cardiol. 2002 Jan 15;89(2):198-203
references: 11792342
references: Hypertension. 1994 Jun;23(6 Pt 2):869-77
references: 8206620
references: J Am Coll Cardiol. 1989 Feb;13(2):337-9
references: 2913111
references: N Engl J Med. 2011 Jan 6;364(1):11-21
references: 21073363
references: Lancet. 2009 Apr 11;373(9671):1289-300
references: 19362677
references: N Engl J Med. 1986 Jun 12;314(24):1547-52
references: 3520315
references: N Engl J Med. 2002 Mar 21;346(12):877-83
references: 11907286
references: JAMA. 1995 May 10;273(18):1450-6
references: 7654275
references: Eur Heart J. 2005 Aug;26(15):1519-27
references: 15917275
references: J Am Coll Cardiol. 1996 Aug;28(2):376-82
references: 8800113
references: Health Aff (Millwood). 2009 Jan-Feb;28(1):179-89
references: 19124869
references: N Engl J Med. 2001 May 31;344(22):1651-8
references: 11386263
references: N Engl J Med. 2004 May 20;350(21):2140-50
references: 15152059
references: Ann Intern Med. 2001 Apr 3;134(7):550-60
references: 11281737
references: Cardiol Res Pract. 2010 Sep 30;2011:
references: 20953365
references: Circulation. 1992 Jun;85(6):2119-31
references: 1591831
references: Int J Clin Pract. 2008 Sep;62(9):1397-402
references: 18793376
references: N Engl J Med. 1997 Feb 20;336(8):525-33
references: 9036306
references: Cardiology. 1994;84 Suppl 2:155-61
references: 7954539
references: Am J Cardiol. 1984 Jan 1;53(1):120-6
references: 6691248
references: Am Heart J. 2005 Sep;150(3):448-54
references: 16169322
references: Congest Heart Fail. 1999 Sep-Oct;5(5):208-215
references: 12189302
references: Heart. 2006 Jan;92(1):12-6
references: 16159969
references: N Engl J Med. 2005 Apr 14;352(15):1539-49
references: 15753115
references: Br J Clin Pharmacol. 1995 Aug;40(2):141-4
references: 8562296
references: Eur Heart J. 2010 Nov;31(21):2677-87
references: 20801924
references: Heart. 2007 Sep;93(9):1137-46
references: 17699180
references: N Engl J Med. 2006 Jul 20;355(3):260-9
references: 16855266
references: J Am Coll Cardiol. 2005 Apr 5;45(7):969-81
references: 15808750
references: Circulation. 2007 Sep 25;116(13):1482-7
references: 17724259
references: J Am Coll Cardiol. 1991 Feb;17(2):422-30
references: 1825095
references: N Engl J Med. 2008 Dec 4;359(23):2456-67
references: 19001508
references: Am Heart J. 1999 Feb;137(2):352-60
references: 9924171
references: Eur Heart J. 2001 Feb;22(3):228-36
references: 11161934
references: Eur Heart J. 2008 Oct;29(19):2388-442
references: 18799522
references: BMJ. 2004 Jan 24;328(7433):189
references: 14729656
references: Intern Emerg Med. 2008 Sep;3(3):205-12
references: 18299800
references: JAMA. 2009 Apr 8;301(14):1439-50
references: 19351941
references: J Thorac Cardiovasc Surg. 2007 Dec;134(6):1540-7
references: 18023680
references: Lancet. 1999 Jun 12;353(9169):2001-7
references: 10376614
references: Lancet. 2003 Sep 6;362(9386):777-81
references: 13678871
references: Heart. 2002 Jan;87(1):75-6
references: 11751672
references: Future Cardiol. 2010 Nov;6(6):743-7
references: 21142628
references: Ann Intern Med. 1992 Aug 1;117(3):234-42
references: 1616218
references: Clin Pharmacokinet. 1996 Mar;30(3):229-49
references: 8882303
references: Eur Heart J. 2000 Jan;21(1):53-7
references: 10610744
references: Lancet. 1999 Jan 2;353(9146):9-13
references: 10023943
references: JAMA. 2000 Mar 8;283(10):1295-302
references: 10714728
references: Circulation. 1998 Nov 24;98(21):2282-9
references: 9826315
references: N Engl J Med. 2009 Oct 1;361(14):1329-38
references: 19723701
references: J Am Coll Cardiol. 2009 Apr 14;53(15):e1-e90
references: 19358937
references: Herz. 2000 Aug;25(5):538-46
references: 10993002
references: Circulation. 1999 Dec 7;100(23):2312-8
references: 10587334
references: Cochrane Database Syst Rev. 2010 Aug 04;(8):CD007228
references: 20687083
references: J Am Coll Cardiol. 2010 Jan 26;55(4):271-82
references: 20117430
references: Heart. 1998 Jul;80(1):5-6
references: 9764049
references: Circulation. 1991 Nov;84(5):2181-6
references: 1834367
references: Eur Heart J. 1999 Jan;20(2):93-102
references: 10099905