title: [Effects of carteolol hydrochloride on experimental choroidal neovascularization].
abstract: OBJECTIVE
  To investigate the effects of carteolol hydrochloride on choroidal neovascularization (CNV).
  
  
  METHODS
  Laser photocoagulation was performed to induce CNV in C 57 BL/6 mice. The response of CNV was assessed by fluorescein isothiocyanate-isolectin B 4 staining. The expression of intercellular adhesion molecule (ICAM)-1 and monocyte chemotactic protein (MCP)-1 in the retinal pigment epithelium (RPE)-choroid complex and tumor necrosis factor (TNF)-alpha in the RAW 264.7 macrophage culture was evaluated by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Carteolol hydrochloride application led to significant suppression of the generation of CNV, the production of ICAM-1 and MCP-1 in the RPE-choroid, and macrophage expression of TNF-alpha.
  
  
  CONCLUSIONS
  Carteolol hydrochloride prevented CNV development through its anti-inflammatory action.
authors: Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. ishidasu@med.hokudai.ac.jp
authors: Susumu
authors: S
authors: Ishida
authors: Hiroshi
authors: H
authors: Mochimaru
authors: Norihiro
authors: N
authors: Nagai
authors: Kousuke
authors: K
authors: Noda
authors: Yoko
authors: Y
authors: Ozawa