title: Methylated promoters of genes encoding protocadherins as a new cancer biomarker family.
abstract: Protocadherins are a major subfamily of the cadherin superfamily. Their functions and intracellular signal transduction are poorly understood, although some have been explored in nervous system development. However, recent researches have shown that protocadherins frequently act as tumor suppressor genes (TSGs) and inactivation of these genes through promoter methylation is closely correlated with tumor development. Furthermore, these methylated protocadherins may serve as tumor biomarkers in various body fluids, stool and scrapings not only for early cancer diagnosis, but also for assessing prognosis and monitoring response to therapy. Thus, methylated promoters of genes encoding protocadherins show promise as a new cancer biomarker family.
authors: Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang 310016, China.
authors: Xinbing
authors: X
authors: Sui
authors: Da
authors: D
authors: Wang
authors: Shumin
authors: S
authors: Geng
authors: Gongli
authors: G
authors: Zhou
authors: Chao
authors: C
authors: He
authors: Xiaotong
authors: X
authors: Hu
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