title: Using magnetoencephalography to investigate brain activity during high frequency deep brain stimulation in a cluster headache patient.
abstract: OBJECTIVE
  Treatment-resistant cluster headache can be successfully alleviated with deep brain stimulation (DBS) of the posterior hypothalamus [1]. Magnetoencephalography (MEG) is a non-invasive functional imaging technique with both high temporal and high spatial resolution. However, it is not known whether the inherent electromagnetic (EM) noise produced by high frequency DBS is compatible with MEG.
  
  
  METHODS
  We used MEG to record brain activity in an asymptomatic cluster headache patient with a DBS implanted in the right posterior hypothalamus while he made small movements during periods of no stimulation, 7 Hz stimulation and 180 Hz stimulation.
  
  
  RESULTS
  We were able to measure brain activity successfully both during low and high frequency stimulation. Analysis of the MEG recordings showed similar activation in motor areas in during the patient's movements as expected. We also observed similar activations in cortical and subcortical areas that have previously been reported to be associated with pain when the patient's stimulator was turned on or off [2,3].
  
  
  CONCLUSIONS
  These results show that MEG can be used to measure brain activity regardless of the presence of high frequency deep brain stimulation.
authors: Department of Physiology, Anatomy and Genetics, University of Oxford, UK.
authors: Nj
authors: Nj
authors: Ray
authors: Ml
authors: M
authors: Kringelbach
authors: N
authors: N
authors: Jenkinson
authors: Slf
authors: S
authors: Owen
authors: P
authors: P
authors: Davies
authors: S
authors: S
authors: Wang
authors: N
authors: N
authors: De Pennington
authors: Pc
authors: P
authors: Hansen
authors: J
authors: J
authors: Stein
authors: Tz
authors: T
authors: Aziz
references: Neurosurgery. 2003 May;52(5):1095-9; discussion 1099-101
references: 12699552
references: J Comp Neurol. 2003 Sep 15;464(2):220-37
references: 12898614
references: Curr Psychiatry Rep. 2006 Dec;8(6):437-44
references: 17094923
references: Neuroimage. 2002 May;16(1):103-14
references: 11969322
references: Science. 2002 Mar 1;295(5560):1737-40
references: 11834781
references: Methods. 2001 Oct;25(2):249-71
references: 11812209
references: Neuroreport. 2007 Feb 12;18(3):223-8
references: 17314661
references: Neuropsychopharmacology. 2006 Nov;31(11):2384-93
references: 16855529
references: Pain. 2007 Mar;128(1-2):101-10
references: 17070996
references: J Clin Neurosci. 2007 Oct;14(10):955-60
references: 17689083
references: Epilepsia. 2006 Nov;47(11):1958-62
references: 17116040