title: Impact of noise or styrene exposure on the kinetics of presbycusis.
abstract: Presbycusis, or age-related hearing loss is a growing problem as the general population ages. In this longitudinal study, the influence of noise or styrene exposure on presbycusis was investigated in Brown Norway rats. Animals were exposed at 6 months of age, either to a band noise centered at 8 kHz at a Lex,8h = 85 dB (86.2 dB SPL for 6 h), or to 300 ppm of styrene for 6 h per day, five days per week, for four weeks. Cubic distortion product otoacoustic emissions (2f1-f2 DPOAEs) were used to test the capacity of the auditory receptor over the lifespan of the animals. 2f1-f2DPOAE measurements are easy to implement and efficiently track the age-related deterioration of mid- and high-frequencies. They are good indicators of temporary auditory threshold shift, especially with a level of primaries close to 60 dB SPL. Post-exposure hearing defects are best identified using moderate, rather than high, levels of primaries. Like many aging humans, aging rats lose sensitivity to high-frequencies faster than to medium-frequencies. Although the results obtained with the styrene exposure were not entirely conclusive, histopathological data showed the presbycusis process to be enhanced. Noise-exposed rats exhibit a loss of spiral ganglion cells from 12 months and a 7 dB drop in 2f1-f2DPOAEs at 24 months, indicating that even moderate-intensity noise can accelerate the presbycusis process. Even though the results obtained with the styrene exposure are less conclusive, the histopathological data show an enhancement of the presbycusis process.
authors: Institut National de Recherche et de Sécurité, Rue du Morvan, CS 60027, 54519 Vandœuvre Cédex, France. Pierre.campo@inrs.fr
authors: Pierre
authors: P
authors: Campo
authors: Thomas
authors: T
authors: Venet
authors: Cécile
authors: C
authors: Rumeau
authors: Aurélie
authors: A
authors: Thomas
authors: Benoît
authors: B
authors: Rieger
authors: Chantal
authors: C
authors: Cour
authors: Frédéric
authors: F
authors: Cosnier
authors: Cécile
authors: C
authors: Parietti-Winkler