title: Direct resolution of optically active isomers on chiral packings containing ergoline skeletons. 5. Enantioseparation of amino Acid derivatives.
abstract: A new procedure for ergot alkaloid-based chiral stationary phase preparation is described. Synthesis is based on bonding the allyl derivative of terguride to mercaptopropylsilanized silica gel. The packing exhibits higher content of chiral selector, stability, reproducibility, and enantioselectivity toward amino acids compared to that previously studied. The chromatographic behavior of amino acids with different side chains and substituent groups is investigated in order to obtain a deeper insight into the enantiodiscriminative mechanism as well as to determine the limitations and strengths of terguride as a chiral selector for this class of compounds. A variety of factors, including mobile phase parameters such as pH, ionic strength, content and nature of organic modifier, and temperature, are examined.
authors: Dipartimento di Chimica, Università di Roma "La Sapienza", Piazzale Aldo Moro 5, I-00185 Roma, Italy, Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnskà 1083, C-142 20 Prague 4, Czech Republic, Istituto di Cromatografia, CNR-Area della Ricerca di Roma, P.O. Box 10, I-00016 Monterotondo Stazione, Roma, Italy, and Galena Opava, Opava, Czech Republic.
authors: A
authors: A
authors: Messina
authors: A M
authors: AM
authors: Girelli
authors: M
authors: M
authors: Flieger
authors: M
authors: M
authors: Sinibaldi
authors: P
authors: P
authors: Sedmera
authors: L
authors: L
authors: Cvak