title: Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents.
abstract: Little is known about the expression of heme transporters in human placenta and possible associations between these transporters and maternal or neonatal iron status. To address this area of research, relative protein expression of 2 heme transporters, Feline Leukemia Virus, Subgroup C, Receptor 1 (FLVCR1) and Breast Cancer Resistance Protein (BCRP), was assessed using Western-blot analysis in human placental tissue in relation to maternal/neonatal iron status and placental iron concentration. Placental FLVCR1 (n = 71) and BCRP (n = 83) expression were assessed at term (36.6-41.7 wk gestation) in a cohort of pregnant adolescents (13-18 y of age) at high-risk of iron deficiency. Both FLVCR1 and BCRP were detected in all placental samples assayed. Placental FLVCR1 expression was positively related to placental BCRP expression (n = 69; R(2) = 0.104; P < 0.05). Adolescents that were anemic at delivery had lower placental FLVCR1 expression (n = 49; P < 0.05). Placental FLVCR1 expression was positively associated with placental iron concentration at delivery (n = 61; R(2) = 0.064; P < 0.05). In contrast, placental BCRP expression was not significantly associated with maternal iron status or placental iron content. Both FLVCR1 and BCRP are highly expressed in human placental tissue, but only FLVCR1 was significantly inversely associated with maternal iron status and placental iron concentration. Further analysis is needed to explore potential functional roles of FLVCR1 in human placental iron transport.
authors: Cornell University, Division of Nutritional Sciences, Ithaca, NY 14853-0001, USA.
authors: Lindsay M
authors: LM
authors: Jaacks
authors: Melissa F
authors: MF
authors: Young
authors: Bridget V
authors: BV
authors: Essley
authors: Thomas J
authors: TJ
authors: McNanley
authors: Elizabeth M
authors: EM
authors: Cooper
authors: Eva K
authors: EK
authors: Pressman
authors: Allison W
authors: AW
authors: McIntyre
authors: Mark S
authors: MS
authors: Orlando
authors: Janis L
authors: JL
authors: Abkowitz
authors: Ronnie
authors: R
authors: Guillet
authors: Kimberly O
authors: KO
authors: O'Brien
references: Proc Nutr Soc. 1974 Dec;33(3):275-84
references: 4459970
references: MMWR Morb Mortal Wkly Rep. 1989 Jun 9;38(22):400-4
references: 2542755
references: Blood. 1986 Sep;68(3):726-31
references: 3742051
references: Am J Clin Nutr. 1997 Aug;66(2):347-56
references: 9250114
references: Cancer Res. 2004 Feb 15;64(4):1247-51
references: 14973083
references: N Engl J Med. 1999 Dec 23;341(26):1986-95
references: 10607817
references: Blood Cells Mol Dis. 2005 Sep-Oct;35(2):189-92
references: 15996880
references: Mol Cell Biol. 2010 Nov;30(22):5318-24
references: 20823265
references: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15649-54
references: 12429862
references: J Biol Chem. 1990 Aug 15;265(23):13981-5
references: 2380200
references: Adv Hematol. 2010;2010:790632
references: 20454576
references: J Clin Endocrinol Metab. 2009 Jun;94(6):2066-74
references: 19258402
references: Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15665-70
references: 9861027
references: Blood. 2003 May 1;101(9):3359-64
references: 12521995
references: Cancer Res. 2001 Apr 15;61(8):3458-64
references: 11309308
references: Am J Clin Nutr. 1998 Dec;68(6):1241-6
references: 9846853
references: Acta Obstet Gynecol Scand. 2002 Oct;81(10):931-7
references: 12366483
references: Am J Clin Nutr. 1990 Feb;51(2):301-8
references: 2407101
references: J Trace Elem Med Biol. 2006;19(4):243-9
references: 16443172
references: Pharmacogenetics. 2003 Jan;13(1):19-28
references: 12544509
references: Br J Haematol. 1990 Aug;75(4):603-9
references: 2207011
references: DNA Cell Biol. 2002 Apr;21(4):271-80
references: 12042067
references: Arch Dis Child. 1951 Jun;26(127):205-14
references: 14857788
references: Oncogene. 2003 Oct 20;22(47):7340-58
references: 14576842
references: Adv Drug Deliv Rev. 2009 Jan 31;61(1):3-13
references: 19135109
references: Blood. 1992 Oct 15;80(8):1940-9
references: 1391953
references: Cell. 2004 Sep 17;118(6):757-66
references: 15369674
references: Annu Rev Pharmacol Toxicol. 2006;46:381-410
references: 16402910
references: Blood. 2008 Jul 15;112(2):219-30
references: 18606887
references: J Am Soc Nephrol. 2002 Feb;13(2):423-430
references: 11805171
references: Drug Metab Dispos. 2006 Apr;34(4):524-33
references: 16415123
references: Science. 2008 Feb 8;319(5864):825-8
references: 18258918
references: J Virol. 1999 Aug;73(8):6500-5
references: 10400745
references: Mol Aspects Med. 2001 Feb-Apr;22(1-2):1-87
references: 11207374
references: J Biol Chem. 2010 Sep 10;285(37):28874-82
references: 20610401
references: Placenta. 2010 Nov;31(11):1010-4
references: 20828813
references: Drug Metab Dispos. 2005 Jan;33(1):94-101
references: 15475413
references: J Pediatr. 2002 Feb;140(2):165-70
references: 11865266
references: Antioxid Redox Signal. 2010 Feb;12(2):261-73
references: 19659436