title: Primary signet ring cell mucinous ovarian carcinoma: a case report and literature review.
abstract: A 24-year-old female patient presented with an extremely rare primary signet cell carcinoma of the right ovary 1 year after surgery for a mucinous borderline tumour of the left ovary. Relaparotomy was carried out with right adnexectomy, appendectomy and partial omentectomy. Surgery was followed by 6 courses of paclitaxel/carboplatinum chemotherapy. After an initial response, the patient again developed increasing ascites. The patient was transferred to our hospital and a re-relaparotomy was carried out, completing the operation. After 3 courses of pegylated doxorubicin/trabectedin, the clinical course showed a positive response and a decline of the tumour marker CEA in peripheral blood. After 5 months, ascites developed in the retroperitoneum so that the chemotherapy had to be changed. In spite of a positive response with the new chemotherapy, the patient died of a very rare pulmonary complication after 1 month within 2 days.
authors: Department of Gynaecology and Obstetrics, University Hospital Giessen and Marburg GmbH, Giessen, Germany.
authors: Samer
authors: S
authors: El-Safadi
authors: Ulrich
authors: U
authors: Stahl
authors: Hans Rudolf
authors: HR
authors: Tinneberg
authors: Andreas
authors: A
authors: Hackethal
authors: Karsten
authors: K
authors: Muenstedt
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