title: Serotonin induces long-term depression at corticostriatal synapses.
abstract: The striatum has important roles in motor control and action learning and, like many brain regions, receives multiple monoaminergic inputs. We have examined serotonergic modulation of rat and mouse corticostriatal neurotransmission and find that serotonin (5-HT) activates 5-HT(1b) receptors resulting in a long-term depression (LTD) of glutamate release and striatal output that we have termed 5-HT-LTD. 5-HT-LTD is presynaptically mediated, cAMP pathway dependent, and inducible by endogenous striatal 5-HT, as revealed by application of a selective 5-HT reuptake inhibitor. 5-HT-LTD is mutually occlusive with dopamine/endocannabinoid-dependent LTD, suggesting that these two forms of LTD act on the same corticostriatal terminals. Thus, serotonergic and dopaminergic mechanisms exist that may interact to persistently sculpt corticostriatal circuits, potentially influencing action learning and striatal-based disorders.
authors: Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20852-9411, USA.
authors: Brian N
authors: BN
authors: Mathur
authors: Nicole A
authors: NA
authors: Capik
authors: Veronica A
authors: VA
authors: Alvarez
authors: David M
authors: DM
authors: Lovinger
references: Nature. 1998 May 14;393(6681):175-8
references: 9603521
references: Neuropharmacology. 2008 Jan;54(1):79-86
references: 17675102
references: Brain Res Rev. 2008 Aug;58(2):272-81
references: 18054796
references: Drug Discov Today. 2008 Apr;13(7-8):325-32
references: 18405845
references: Eur J Neurosci. 2009 Apr;29(8):1604-14
references: 19419423
references: Neuropsychopharmacology. 1999 Aug;21(2 Suppl):9S-15S
references: 10432483
references: Neuron. 2004 Oct 28;44(3):483-93
references: 15504328
references: J Biol Chem. 2003 Dec 5;278(49):48973-80
references: 14517212
references: Mol Pharmacol. 2000 Dec;58(6):1271-8
references: 11093763
references: Nat Neurosci. 2004 May;7(5):483
references: 15114362
references: Nature. 2007 Aug 23;448(7156):894-900
references: 17713528
references: Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4
references: 1557407
references: J Physiol (Paris). 1981;77(2-3):157-74
references: 6169825
references: J Neurosci. 2007 May 9;27(19):5260-4
references: 17494712
references: Nature. 2007 Feb 8;445(7128):643-7
references: 17287809
references: Brain Res. 1996 Apr 15;716(1-2):123-33
references: 8738228
references: Nat Neurosci. 2002 May;5(5):446-51
references: 11976704
references: Brain Res. 1989 Feb 27;481(1):67-86
references: 2706468
references: Eur J Neurosci. 2007 Jun;25(11):3226-32
references: 17552991
references: J Neurosci. 2005 Nov 9;25(45):10537-45
references: 16280591
references: Prog Brain Res. 2008;172:423-63
references: 18772045
references: Neuroscience. 1994 Jan;58(1):167-82
references: 8159291
references: Eur J Neurosci. 1998 Jul;10(7):2371-9
references: 9749765
references: Eur J Neurosci. 2009 Jan;29(1):32-41
references: 19120438
references: Neuroscience. 1999;88(3):899-915
references: 10363826
references: Eur J Pharmacol. 1988 Jul 7;151(2):189-96
references: 2971554
references: J Neurosci. 2008 Jun 18;28(25):6508-15
references: 18562622