title: Lung adenocarcinoma presenting as a solitary gingival metastasis: a case report.
abstract: BACKGROUND
  Gingival metastases are very rare and generally occur in disseminated tumors. We report a case of solitary gingival metastasis of lung cancer.
  
  
  METHODS
  We report the case of a 74-year-old asymptomatic Caucasian woman affected by a rapidly growing, painless gingival swelling. Histopathologic examination of the excisional biopsy showed metastasis of poorly differentiated thyroid transcription factor 1-positive adenocarcinoma. A total-body computed tomographic scan revealed a tumor of the right lung lower lobe with ipsilateral, mediastinal lymph node swelling. Moreover, bone scintigraphy revealed no bone metastases. No other metastases were found, so we planned a multi-modal therapeutic approach with a curative intent. However, the tumor proved to be intrinsically resistant and highly aggressive.
  
  
  CONCLUSIONS
  The presentation of solitary gingival metastasis is exceptional. In view of its rapid clinical evolution, our case confirms that gingival metastasis is an important prognostic factor. This behavior raises the question whether the poor prognosis for patients with tumors with oral metastases depends on its diffuse spread or on its highly malignant nature.
authors: Division of Medical Oncology, Catholic University of Sacred Heart, Rome, Italy. armando.orlandi@edu.rm.unicatt.it.
authors: Armando
authors: A
authors: Orlandi
authors: Michele
authors: M
authors: Basso
authors: Mariantonietta
authors: M
authors: Di Salvatore
authors: Francesco
authors: F
authors: Federico
authors: Alessandra
authors: A
authors: Cassano
authors: Carlo
authors: C
authors: Barone
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