title: Why is it crucial to reintegrate pathology into cancer research?
abstract: The integration of pathology with molecular biology is vital if we are to enhance the translational value of cancer research. Pathology represents a bridge between medicine and basic biology, it remains the gold standard for cancer diagnosis, and it plays an important role in discovery studies. In the past, pathology and cancer research were closely associated; however, the molecular biology revolution has shifted the focus of investigators toward the molecular alterations of tumors. The reductionist approach taken in molecular studies is producing great insight into the inner workings of neoplasia, but it can also minimize the importance of histopathology and of understanding the disease as a whole. In turn, pathologists can underestimate the role of molecular studies in developing new ancillary techniques for clinical diagnosis. A multidisciplinary approach that integrates pathology and molecular biology within a translational research system is needed. This process will require overcoming cultural barriers and can be achieved through education, a more effective incorporation of pathology into biological research, and conversely an integration of biological research into the pathology laboratory.
authors: Laser Capture Microdissection Core and Pathogenetics Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. rodrigja@mail.nih.gov
authors: Jaime
authors: J
authors: Rodriguez-Canales
authors: Franziska C
authors: FC
authors: Eberle
authors: Elaine S
authors: ES
authors: Jaffe
authors: Michael R
authors: MR
authors: Emmert-Buck
references: Cancer J. 2001 Jan-Feb;7(1):32-9
references: 11269646
references: Arch Pathol Lab Med. 2008 May;132(5):774-6
references: 18466023
references: J Mol Diagn. 2000 May;2(2):60-6
references: 11272889
references: Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:31-9
references: 15209401
references: Cell Cycle. 2006 Aug;5(15):1597-601
references: 16880743
references: Health Info Libr J. 2009 Mar;26(1):56-62
references: 19245644
references: Lab Invest. 2010 May;90(5):787-96
references: 20195244
references: Nat Rev Cancer. 2010 Dec;10(12):878-89
references: 21102637
references: Rev Med Chil. 1995 Oct;123(10):1306-12
references: 8733325
references: Adv Exp Med Biol. 2010;671:67-73
references: 20455496
references: Dev Cell. 2010 Jun 15;18(6):884-901
references: 20627072
references: Science. 1997 Apr 18;276(5311):404-7
references: 9103196
references: Scand J Gastroenterol. 2009;44(7):787-95
references: 19391063
references: BMC Syst Biol. 2010 Nov 26;4:162
references: 21110851
references: Clin Exp Metastasis. 2008;25(1):81-8
references: 17932773
references: PLoS Med. 2006 May;3(6):e208
references: 16681415
references: Am J Surg Pathol. 1984 Apr;8(4):301-7
references: 6369999
references: J Mol Diagn. 2004 Nov;6(4):371-7
references: 15507677
references: Nature. 2000 Aug 17;406(6797):747-52
references: 10963602
references: Haematologica. 2011 Apr;96(4):558-66
references: 21454882
references: Acta Pathol Jpn. 1964 Jan;14:147-66
references: 14196556
references: Cancer. 2007 Oct 15;110(8):1641-3
references: 17763370
references: Endocr Pathol. 2008 Fall;19(3):139-47
references: 18758692
references: Mol Med. 2009 Jan-Feb;15(1-2):60-3
references: 19043478
references: Nature. 2009 Sep 3;461(7260):27-32
references: 19727179
references: Virchows Arch. 2010 Jun;456(6):599-607
references: 20422212
references: PLoS One. 2010 Nov 30;5(11):e14031
references: 21152421
references: Cancer Res. 2009 Feb 1;69(3):758-64
references: 19155300
references: BMC Med Genomics. 2009 Mar 09;2:13
references: 19272143
references: JAMA. 2008 Oct 1;300(13):1580-1
references: 18827215
references: N Engl J Med. 2002 Nov 14;347(20):1593-603
references: 12432047
references: J Mol Diagn. 2009 Nov;11(6):497-507
references: 19797613
references: J Mol Diagn. 2010 Jul;12(4):394-401
references: 20413681
references: Nat Protoc. 2009;4(6):902-22
references: 19478806
references: Annu Rev Pathol. 2009;4:229-49
references: 18840073
references: Cancer. 2009 Jul 1;115(13 Suppl):3078-84
references: 19544549
references: Science. 1996 Nov 8;274(5289):998-1001
references: 8875945
references: Cytopathology. 2011 Feb;22(1):36-42
references: 20977506
references: Blood. 2008 Dec 1;112(12):4384-99
references: 19029456
references: Cancer Chemother Pharmacol. 2009 Mar;63(4):571-82
references: 19083000
references: Trans Med Soc Lond. 2011-2012;128:24-35
references: 24941652
references: Lab Invest. 2008 Jan;88(1):18-26
references: 18040269
references: Radiat Prot Dosimetry. 2003;105(1-4):39-42
references: 14526924
references: Cell. 2000 Jan 7;100(1):57-70
references: 10647931
references: Nat Biotechnol. 2008 Sep;26(9):978-9; discussion 979
references: 18779800
references: Nature. 2001 Feb 15;409(6822):860-921
references: 11237011
references: Nature. 2007 Dec 6;450(7171):893-8
references: 17982442
references: Diagn Mol Pathol. 2007 Dec;16(4):189-97
references: 18043281
references: Mol Biotechnol. 2005 Feb;29(2):119-52
references: 15699569
references: Arch Pathol Lab Med. 2011 Jan;135(1):67-82
references: 21204713
references: Science. 2005 Oct 28;310(5748):644-8
references: 16254181
references: Eur J Cancer. 2009 May;45(8):1518-26
references: 19272767
references: Cancer J. 2009 Mar-Apr;15(2):129-37
references: 19390308
references: Cancer Res. 1997 May 15;57(10):1855-8
references: 9157974
references: Cell Cycle. 2008 Mar 1;7(5):570-2
references: 18256538
references: Ann Diagn Pathol. 1998 Apr;2(2):146-8
references: 9845732
references: Nature. 2010 Feb 18;463(7283):858
references: 20164888
references: Curr Opin Oncol. 2011 Jan;23(1):62-8
references: 21119514
references: Adv Anat Pathol. 2010 Nov;17(6):394-403
references: 20966645
references: N Engl J Med. 2010 Mar 11;362(10):875-85
references: 20220182
references: J Vet Diagn Invest. 2007 Jul;19(4):455-6
references: 17609364
references: Curr Issues Mol Biol. 2003 Apr;5(2):27-35
references: 12793526
references: Lab Invest. 2007 May;87(5):403-8
references: 17401434