title: No association between polymorphisms and haplotypes of COL1A1 and COL1A2 genes and osteoporotic fracture in postmenopausal Chinese women.
abstract: OBJECTIVE
  To study whether genetic polymorphisms of COL1A1 and COL1A2 genes affected the onset of fracture in postmenopausal Chinese women.
  
  
  METHODS
  SNPs in COL1A1 and COL1A2 genes were identified via direct sequencing in 32 unrelated postmenopausal Chinese women. Ten SNPs were genotyped in 1252 postmenopausal Chinese women. The associations were examined using both single-SNP and haplotype tests using logistic regression.
  
  
  RESULTS
  Twenty four (4 novel) and 28 (7 novel) SNPs were identified in COL1A1 and COL1A2 gene, respectively. The distribution frequencies of 2 SNPs in COL1A1 (rs2075554 and rs2586494) and 3 SNPs in COL1A2 (rs42517, rs1801182, and rs42524) were significantly different from those documented for the European Caucasian population. No significant difference was observed between fracture and control groups with respect to allele frequency or genotype distribution in 9 selected SNPs and haplotype. No significant association was found between fragility fracture and each SNP or haplotype. The results remained the same after additional corrections for other risk factors such as weight, height, and bone mineral density.
  
  
  CONCLUSIONS
  Our results show no association between common genetic variations of COL1A1 and COL1A2 genes and fracture, suggesting the complex genetic background of osteoporotic fractures.
authors: Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors: Wei-wei
authors: WW
authors: Hu
authors: Jin-wei
authors: JW
authors: He
authors: Hao
authors: H
authors: Zhang
authors: Chun
authors: C
authors: Wang
authors: Jie-mei
authors: JM
authors: Gu
authors: Hua
authors: H
authors: Yue
authors: Yao-hua
authors: YH
authors: Ke
authors: Yun-qiu
authors: YQ
authors: Hu
authors: Wen-zhen
authors: WZ
authors: Fu
authors: Miao
authors: M
authors: Li
authors: Yu-juan
authors: YJ
authors: Liu
authors: Zhen-lin
authors: ZL
authors: Zhang
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