title: CCL4L polymorphisms and CCL4/CCL4L serum levels are associated with psoriasis severity.
abstract: Psoriasis is a common inflammatory skin disease with key immunological and genetic components. Recruitment of leukocytes into the skin is a central step in its pathogenesis, mediated by cytokines. Among the cytokines expressed in psoriatic lesions, C-C chemokine ligand 4 (CCL4) and C-C chemokine ligand 4-like (CCL4L) chemokines appear to be pivotal elements for the skin recruitment of proinflammatory cells. The aim of this study is to evaluate the relationship between CCL4L polymorphisms (including single-nucleotide polymorphisms (SNPs) and copy number variation (CNV)) and the course and prognosis of psoriasis. We analyzed the CNV and the rs4796195 SNP in 211 psoriatic patients and 234 controls; sera from both populations were also quantified for CCL4/CCL4L protein. Our results showed that a high CNV (≥3 copies) is associated with psoriasis severity, whereas moderate disease correlated with a lower CNV (≤2 copies); specifically, the CCL4L1 allele frequency is higher in severe psoriasis, whereas CCL4L2 is more frequent in patients with a milder disease. In addition, we found a positive correlation between the CNV and sera protein levels. Our results suggest that CCL4L genotyping could not only allow a better understanding of the psoriatic pathogenesis but could also be used as a prognostic tool, even helping to modulate the efficacy of treatments.
authors: Laboratory of Immunobiology for Research and Application to Diagnosis, Tissue and Blood Bank (BST), Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain.
authors: Edurne
authors: E
authors: Pedrosa
authors: Laura
authors: L
authors: Carretero-Iglesia
authors: Aram
authors: A
authors: Boada
authors: Roger
authors: R
authors: Colobran
authors: Rosa
authors: R
authors: Faner
authors: Irma
authors: I
authors: Pujol-Autonell
authors: Eduard
authors: E
authors: Palou
authors: Anna
authors: A
authors: Esteve
authors: Ricardo
authors: R
authors: Pujol-Borrell
authors: Carlos
authors: C
authors: Ferrándiz
authors: Manel
authors: M
authors: Juan
authors: José-Manuel
authors: JM
authors: Carrascosa