title: Synthesis, characterization and in vitro drug release of magnetic N-benzyl-O-carboxymethylchitosan nanoparticles loaded with indomethacin.
abstract: Magnetic N-benzyl-O-carboxymethylchitosan nanoparticles were synthesized through incorporation and in situ methods and characterized by Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, and magnetization measurements. Indomethacin was incorporated into the nanoparticles via the solvent evaporation method. The indomethacin-loaded magnetic nanoparticles were characterized by the same techniques, and also by transmission electron microscopy. The nanoparticles containing the polymer showed a drug loading efficiency of between 60.8% and 74.8%, and the magnetic properties were not significantly affected by incorporation of the drug. The in vitro drug release study was carried out in simulated body fluid, pH 7.4 at 37°C. The profiles showed an initial fast release, which became slower as time progressed. The percentage of drug released after 5 h was between 60% and 90%, and the best fitting mathematical model for drug release was the Korsmeyer-Peppas model, indicating a Fickian diffusion mechanism.
authors: NIQFAR CCS, Universidade do Vale do Itajaí, CEP 88302-202, Itajaí, SC, Brazil.
authors: Aline
authors: A
authors: Debrassi
authors: Cristiani
authors: C
authors: Bürger
authors: Clóvis Antonio
authors: CA
authors: Rodrigues
authors: Nataliya
authors: N
authors: Nedelko
authors: Anna
authors: A
authors: Ślawska-Waniewska
authors: Piotr
authors: P
authors: Dłużewski
authors: Kamil
authors: K
authors: Sobczak
authors: Jean-Marc
authors: JM
authors: Greneche