title: Investigations on interpolymer complexes of cationic guar gum and xanthan gum for formulation of bioadhesive films.
abstract: The present study was aimed at evaluating the possible use of inter polymer complexed (IPC) films of xanthan gum (XG) and cationic guar gum (CGG) for formulating domperidone bioadhesive films. Formation of bonds between -COO¯ groups of XG and -N(+)(CH(3))(3) groups of CGG was evident in the FTIR spectra of IPC films. Bioadhesive strength of the films was evaluated employing texture analyser. Water uptake studies indicated swelling to be a function of XG concentration in the interpolymer complexes. The bioadhesive films were found to possess neutral pH. In vitro drug release studies and residence time studies indicated that the film comprising CGG:XG (80:20) released 98% of domperidone in 8 h and exhibited a residence time of approximately 8 h. Enhanced bioavailability of domperidone was observed from bioadhesive films as compared to orally administered conventional tablets. Overall, the findings suggest that IPC films of XG and CGG, exhibiting desired bioadhesive strength and enhanced bioavailability of domperidone, can be prepared.
authors: Ranbaxy Research Labs, Plot No. 20, Sector 18, Gurgaon, India.
authors: M
authors: M
authors: Singh
authors: A K
authors: AK
authors: Tiwary
authors: G
authors: G
authors: Kaur
references: Drug Dev Ind Pharm. 2003 Mar;29(3):321-37
references: 12741613
references: Adv Drug Deliv Rev. 2005 Nov 3;57(11):1666-91
references: 16183164
references: Drug Dev Ind Pharm. 2000 Sep;26(9):913-24
references: 10914315
references: Eur J Pharm Biopharm. 2009 Feb;71(2):325-31
references: 18804532
references: Drug Dev Ind Pharm. 2008 Nov;34(11):1246-66
references: 18720139
references: AAPS PharmSciTech. 2004 Apr 29;5(3):e35
references: 15760069
references: J Pharm Pharmacol. 1991 Jul;43(7):457-64
references: 1682457
references: Eur J Pharm Biopharm. 2009 Mar;71(3):505-18
references: 18984051
references: Sci Pharm. 2010;78(1):57-78
references: 21179370
references: J Biomed Mater Res. 2000 Sep;53(5):592-9
references: 10984709
references: Acta Pharm. 2003 Sep;53(3):199-212
references: 14769243
references: J Control Release. 2000 Jan 3;63(1-2):31-9
references: 10640578
references: Oral Dis. 2006 Jul;12(4):420-3
references: 16792729