title: [Evaluation of cytokine levels and pulmonary function in patients undergoing coronary artery bypass graft].
abstract: OBJECTIVE
  Systemic inflammatory response syndrome is commonly observed in coronary artery bypass grafts (CABG) with cardiopulmonary bypass (CB). The objective of this study was to evaluate the systemic and pulmonary levels of cytokines and their correlation with lung function in patients undergoing myocardial revascularization (MR) with CB.
  
  
  METHODS
  This study was approved by the Institutional Ethics Committee, and 13 patients undergoing MR with CB were evaluated. After anesthetic induction and at the end of CB, plasma and bronchoalveolar lavage levels of IL-1β, IL-6, IL-8, IL-10, and TNF-α were determined. The duration of CB and surgery, PaO(2)/FiO(2) ratio, alveolar-arterial oxygen gradient (A-a gradient), shunt, and lung compliance were evaluated. Results were submitted to analysis of variance for repeated measurements (*p < 0.05) and Spearman's correlation coefficient.
  
  
  RESULTS
  We observed increased levels of cytokines in plasma and bronchoalveolar lavage after CB and a direct relationship between the increase in IL-1β and decrease in lung compliance (p = 0.0439), as well as the inverse relationship between the increase in IL-10 and a decrease in compliance (p = 0.0325). The increase in IL-6 was directly related to the duration of CB (p = 0.012), while the increase in IL-8 was directly related to the duration of surgery (p < 0.0001). Levels of interleukin-1β, IL-8, and TNF-α in bronchoalveolar lavage were higher than in plasma.
  
  
  CONCLUSIONS
  There is an increase in cytokine levels in plasma and bronchoalveolar lavage after CB, as well as a correlation between increased cytokine levels and CB duration and surgery and changes in lung compliance.
authors: Physician of the Serviço de Anestesiologia UNIANEST, Bauru-SP.
authors: Luciano Brandão
authors: LB
authors: Machado
authors: Elnara Marcia
authors: EM
authors: Negri
authors: Wanderley Wesley
authors: WW
authors: Bonafé
authors: Luciana Moraes
authors: LM
authors: Santos
authors: Luís Marcelo
authors: LM
authors: Sá Malbouisson
authors: Maria José Carvalho
authors: MJ
authors: Carmona