title: Regulation of long-term plasticity induction by the channel and C-terminal domains of GluN2 subunits.
abstract: Conventional long-term potentiation (LTP) and long-term depression (LTD) are induced by different patterns of synaptic stimulation, but both forms of synaptic modification require calcium influx through NMDA receptors (NMDARs). A prevailing model (the "calcium hypothesis") suggests that high postsynaptic calcium elevation results in LTP, whereas moderate elevations give rise to LTD. Recently, additional evidence has come to suggest that differential activation of NMDAR subunits also factors in determining which type of plasticity is induced. While the growing amount of data suggest that activation of NMDARs containing specific GluN2 subunits plays an important role in the induction of plasticity, it remains less clear which subunit is tied to which form of plasticity. Additionally, it remains to be determined which properties of the subunits confer upon them the ability to differentially induce long-term plasticity. This review highlights recent studies suggesting differential roles for the subunits, as well as findings that begin to shed light on how two similar subunits may be linked to the induction of opposing forms of plasticity.
authors: Department of Basic Science, The Commonwealth Medical College, 501 Madison Ave., Scranton, PA 18510, USA.
authors: Frank
authors: F
authors: Fetterolf
authors: Kelly A
authors: KA
authors: Foster
references: J Neurophysiol. 2011 Jan;105(1):162-71
references: 20980539
references: Neuron. 1994 Mar;12(3):529-40
references: 7512349
references: Nat Neurosci. 2002 May;5(5):405-14
references: 11953750
references: Neuron. 2001 Jan;29(1):243-54
references: 11182095
references: J Neurosci. 2007 Dec 12;27(50):13649-54
references: 18077676
references: J Neurosci. 2006 Jul 5;26(27):7181-8
references: 16822975
references: J Neurosci. 2003 Nov 26;23(34):10791-9
references: 14645471
references: J Biol Chem. 1999 Sep 24;274(39):27467-73
references: 10488080
references: J Neurosci. 2000 Jun 15;20(12):RC81
references: 10827202
references: J Physiol. 2005 Mar 1;563(Pt 2):345-58
references: 15649985
references: J Neurosci. 2007 Jul 11;27(28):7365-76
references: 17626197
references: Neuron. 2003 Nov 13;40(4):775-84
references: 14622581
references: Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1340-5
references: 12552130
references: Learn Mem. 2011 Jan 21;18(2):118-27
references: 21257779
references: Neuropharmacology. 2007 Jan;52(1):77-86
references: 16901514
references: Biochem Biophys Res Commun. 2000 Apr 21;270(3):903-9
references: 10772923
references: Neuron. 2010 Sep 23;67(6):984-96
references: 20869595
references: Nat Neurosci. 2005 Aug;8(8):1069-77
references: 16025106
references: PLoS One. 2009 Oct 19;4(10):e7486
references: 19838302
references: Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4344-51
references: 16537406
references: Neuron. 2010 Jun 24;66(6):859-70
references: 20620872
references: J Neurosci. 2002 Oct 15;22(20):8902-10
references: 12388597
references: J Neurosci. 2005 Jul 20;25(29):6907-10
references: 16033900
references: Nat Neurosci. 1999 Apr;2(4):352-7
references: 10204542
references: J Neurosci. 2007 Aug 1;27(31):8334-43
references: 17670980
references: Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102
references: 11909726
references: J Pharmacol Exp Ther. 2010 Dec;335(3):636-44
references: 20810618
references: Hippocampus. 2006;16(11):907-15
references: 17024679
references: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3805-10
references: 20133708
references: J Neurophysiol. 1998 Feb;79(2):555-66
references: 9463421
references: Neuron. 1998 Apr;20(4):683-91
references: 9581761
references: Neuropharmacology. 2007 Jan;52(1):71-6
references: 16899258
references: Mol Pharmacol. 2006 Apr;69(4):1251-9
references: 16436589
references: Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12876-80
references: 10536016
references: Nat Rev Neurosci. 2004 Oct;5(10):771-81
references: 15378037
references: J Neurosci. 2004 Nov 10;24(45):10248-59
references: 15537897
references: Trends Cell Biol. 2007 Jul;17(7):343-52
references: 17644382
references: J Neurophysiol. 2008 Oct;100(4):1936-48
references: 18667547
references: J Biol Chem. 2011 Mar 4;286(9):7558-66
references: 21190942
references: Nature. 1994 Mar 10;368(6467):144-7
references: 8139656
references: J Neurosci. 2009 Mar 11;29(10):3109-19
references: 19279248
references: J Neurosci. 2001 Feb 15;21(4):1228-37
references: 11160393
references: J Biol Chem. 2000 Jan 28;275(4):2966-72
references: 10644767
references: Nat Rev Neurosci. 2002 Oct;3(10):791-802
references: 12360323
references: J Neurosci. 2006 Feb 1;26(5):1331-3
references: 16452656
references: J Neurosci. 2010 Mar 31;30(13):4590-600
references: 20357110
references: Nat Neurosci. 2007 Jul;10(7):880-886
references: 17529984
references: Neuroscience. 2008 Jul 17;154(4):1308-17
references: 18538939
references: Nature. 2001 Jun 14;411(6839):801-5
references: 11459059
references: J Biol Chem. 2000 Aug 4;275(31):23798-806
references: 10764765
references: Neuropharmacology. 2002 Mar;42(3):319-24
references: 11897110
references: Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10457-60
references: 8816822
references: Neuropsychopharmacology. 2008 Apr;33(5):1004-18
references: 17625504
references: J Neurosci. 2010 Feb 17;30(7):2676-85
references: 20164351
references: Eur J Neurosci. 2009 Mar;29(6):1141-52
references: 19302150
references: Neuron. 2005 Apr 21;46(2):261-74
references: 15848804
references: Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16697-702
references: 20823230
references: Neuropharmacology. 2009 Jan;56(1):2-5
references: 18655795
references: Mol Pharmacol. 1993 Oct;44(4):851-9
references: 7901753
references: Curr Opin Neurobiol. 2001 Jun;11(3):327-35
references: 11399431
references: J Neurophysiol. 2006 Mar;95(3):1727-34
references: 16319212
references: Neuroscience. 2010 Dec 29;171(4):1102-8
references: 20884329
references: J Neurosci. 2008 Mar 19;28(12):3060-70
references: 18354009
references: Nature. 1995 Jan 12;373(6510):151-5
references: 7816096
references: Eur J Neurosci. 2005 Jul;22(2):485-94
references: 16045501
references: J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92
references: 9400004
references: J Biol Chem. 1996 Dec 6;271(49):31670-8
references: 8940188
references: Brain Res. 2009 Jun 5;1274:40-6
references: 19376094
references: J Biol Chem. 1997 May 23;272(21):13467-70
references: 9153188
references: Neuron. 2005 Oct 20;48(2):289-301
references: 16242409
references: Neuron. 2005 Jun 2;46(5):745-60
references: 15924861
references: J Neurosci. 2000 Feb 1;20(3):1260-71
references: 10648730
references: J Neurosci. 2002 Nov 15;22(22):9721-32
references: 12427827
references: J Biol Chem. 2005 Oct 21;280(42):35329-36
references: 16120608
references: Learn Mem. 2009 May 27;16(6):395-405
references: 19474217
references: Mol Cell Neurosci. 2005 May;29(1):139-47
references: 15866054
references: PLoS Biol. 2009 Feb 24;7(2):e41
references: 19243221
references: Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3239-44
references: 10077668
references: Eur J Pharmacol. 2004 Oct 1;500(1-3):101-11
references: 15464024
references: Eur J Neurosci. 2005 Jan;21(2):339-50
references: 15673434
references: Neuron. 1999 Jul;23(3):583-92
references: 10433269
references: Nature. 1997 Jan 30;385(6615):439-42
references: 9009191
references: J Biol Chem. 2006 Nov 17;281(46):34859-69
references: 16987814
references: Nature. 1996 Jun 6;381(6582):526-8
references: 8632826
references: Ann N Y Acad Sci. 1999 Apr 30;868:494-501
references: 10414326
references: Neuron. 2008 Dec 10;60(5):846-60
references: 19081379
references: J Physiol. 1996 Dec 15;497 ( Pt 3):761-72
references: 9003561
references: Cell. 2002 Oct 18;111(2):219-30
references: 12408866
references: J Neurosci. 2005 Jun 29;25(26):6037-46
references: 15987933
references: Neuropharmacology. 2008 Oct;55(5):871-7
references: 18644393
references: J Neurosci. 2010 Mar 17;30(11):4171-83
references: 20237287
references: Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):649-55
references: 12740110
references: Mol Brain. 2008 Sep 30;1:9
references: 18826591
references: J Neurosci. 2003 Feb 15;23(4):1119-24
references: 12598599
references: Mol Pharmacol. 2001 May;59(5):960-4
references: 11306676
references: J Neurosci. 2005 Sep 14;25(37):8386-90
references: 16162920
references: Cell. 1998 Jan 23;92(2):279-89
references: 9458051
references: J Physiol. 2008 May 15;586(10):2539-50
references: 18372311
references: Neuron. 1996 Feb;16(2):333-44
references: 8789948
references: J Neurosci. 2010 Jun 16;30(24):8162-70
references: 20554866
references: PLoS One. 2010 Jul 22;5(7):e11732
references: 20661302
references: Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10452-6
references: 8816821
references: J Physiol. 2006 May 1;572(Pt 3):789-98
references: 16513670
references: J Neurosci. 2006 Feb 8;26(6):1721-9
references: 16467520
references: J Pharmacol Exp Ther. 2002 Jun;301(3):938-44
references: 12023522
references: J Physiol. 2007 Oct 15;584(Pt 2):509-19
references: 17717018
references: Nature. 1999 Sep 2;401(6748):63-9
references: 10485705
references: Neurosci Lett. 1997 Apr 25;226(2):107-10
references: 9159501
references: J Neurosci. 2009 Jan 21;29(3):669-77
references: 19158293
references: FEBS Lett. 2009 Apr 17;583(8):1226-30
references: 19298817
references: J Neurosci. 2004 Sep 8;24(36):7821-8
references: 15356193
references: J Neurosci. 2010 Nov 10;30(45):15102-12
references: 21068316
references: J Biol Chem. 2001 Jan 5;276(1):693-9
references: 11024032
references: Mol Pharmacol. 2010 Oct;78(4):535-49
references: 20660085
references: Brain Res. 2006 Jan 5;1067(1):103-14
references: 16376317
references: Science. 2004 May 14;304(5673):1021-4
references: 15143284
references: J Neurosci. 1999 May 15;19(10):4180-8
references: 10234045
references: J Neurosci. 2000 Jun 15;20(12):4573-81
references: 10844027
references: Neuron. 2005 Sep 15;47(6):845-57
references: 16157279
references: J Neurosci. 2009 Jul 8;29(27):8764-73
references: 19587283
references: J Neurosci. 1997 Apr 1;17(7):2469-76
references: 9065507
references: Neuropharmacology. 2007 Jan;52(1):60-70
references: 16904707
references: Neuron. 2005 Sep 15;47(6):859-72
references: 16157280
references: J Neurophysiol. 2003 Aug;90(2):786-97
references: 12904493
references: Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11471-6
references: 17592137
references: Eur J Neurosci. 2008 Apr;27(8):1957-64
references: 18412616