title: Mental, psychomotor, neurologic, and behavioral outcomes of 2-year-old children born after preimplantation genetic screening: follow-up of a randomized controlled trial.
abstract: OBJECTIVE
  To evaluate the effect of preimplantation genetic screening (PGS) on neurodevelopmental outcomes in children.
  
  
  METHODS
  Prospective, assessor-blinded, follow-up study of children born to women randomly assigned to in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) with or without PGS.
  
  
  METHODS
  University Medical Center, Groningen, and Academic Medical Center, Amsterdam, the Netherlands.
  
  
  METHODS
  Fifty-four PGS children and 77 controls.
  
  
  METHODS
  PGS.
  
  
  METHODS
  Mental, psychomotor, neurologic, and behavioral outcomes in 2-year-old children as measured with the Bayley Scales of Infant Development, the Hempel neurologic examination, and the Child Behavior Check List.
  
  
  RESULTS
  The mental, psychomotor, and behavioral outcomes at 2 years in children born after IVF with and without PGS were similar overall. The PGS children showed lower neurologic optimality scores than the control children. Scores on all tests were within the normal range.
  
  
  CONCLUSIONS
  Conception with PGS does not seem to be associated with impaired mental, psychomotor, or behavioral outcomes by age 2. However, the lower neurologic optimality scores found in the PGS children may signal less favorable long-term neurologic outcomes in PGS children. Our findings stress the need for safety evaluations with new assisted reproductive techniques before large-scale implementation.
authors: Department of Pediatrics, Division of Developmental Neurology, University Medical Center, Groningen, the Netherlands. k.j.middelburg@developmentalneurology.com
authors: Karin J
authors: KJ
authors: Middelburg
authors: Maaike
authors: M
authors: van der Heide
authors: Bregje
authors: B
authors: Houtzager
authors: Marjolein
authors: M
authors: Jongbloed-Pereboom
authors: Vaclav
authors: V
authors: Fidler
authors: Arend F
authors: AF
authors: Bos
authors: Joke
authors: J
authors: Kok
authors: Mijna
authors: M
authors: Hadders-Algra