title: Neural dynamics in parkinsonian brain: the boundary between synchronized and nonsynchronized dynamics.
abstract: Synchronous oscillatory dynamics is frequently observed in the human brain. We analyze the fine temporal structure of phase-locking in a realistic network model and match it with the experimental data from Parkinsonian patients. We show that the experimentally observed intermittent synchrony can be generated just by moderately increased coupling strength in the basal ganglia circuits due to the lack of dopamine. Comparison of the experimental and modeling data suggest that brain activity in Parkinson's disease resides in the large boundary region between synchronized and nonsynchronized dynamics. Being on the edge of synchrony may allow for easy formation of transient neuronal assemblies.
authors: Department of Mathematical Sciences and Center for Mathematical Biosciences, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA.
authors: Choongseok
authors: C
authors: Park
authors: Robert M
authors: RM
authors: Worth
authors: Leonid L
authors: LL
authors: Rubchinsky
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