title: [Importance of particle size decrease in the preformulation].
abstract: Present work provides a short review concerning the importance of particle size decreasing in the drug formulation. The presented theoretical introduction collects the must important factors which influence the dezintegration and integration mechanisms. Modification of particle size and morphology could overcome the formulation problems, resulted improved drug release. Wet milling and solvent diffusion, as a novel methods to complete with drying will be presented applying the poorly water-soluble niflumic acid. Differences in particle sizes were found according to the used processing. The specific surface area of the drug was increased following particle size reduction and the dissolution rate was therefore significantly improved. During structural characterizations (DSC and XRPD), strong interactions were detected between the drug and stabilizer.
authors: Szegedi Tudományegyetem, Gyógyszertechnológiai Intézet, Szeged, Eötvös u. 6 - 6720.
authors: Tímea
authors: T
authors: Szunyogh
authors: Rita
authors: R
authors: Ambrus
authors: Révész Piroska
authors: RP
authors: Szabóné