title: Diastereoselective intramolecular Friedel-Crafts alkylation of tetralins.
abstract: An efficient and versatile synthesis of cis-hexahydrobenzophenanthridines starting from readily available tetralins has been developed using an intramolecular Friedel-Crafts alkylation as a key step. The substrates were prepared via a highly stereocontrolled rhodium-catalyzed ring-opening reaction of meso-oxabicyclic alkenes and a hydrogenation sequence. Thus, a wide variety of complex tetracyclic compounds have been isolated with a high level of regio-, diastereo-, and enantioselectivity.
authors: Davenport Chemical Laboratories, Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario M5S 3H6, Canada.
authors: Clémence
authors: C
authors: Liébert
authors: Marion K
authors: MK
authors: Brinks
authors: Andrew G
authors: AG
authors: Capacci
authors: Matthew J
authors: MJ
authors: Fleming
authors: Mark
authors: M
authors: Lautens