title: Chemotherapy of human alpha-fetoprotein-producing gastric carcinomas grown in nude mice.
abstract: We have examined the effects of chemotherapeutic drugs on tumor growth and metastasis of human alpha-fetoprotein-producing gastric carcinoma (AFPGC) xenografts growing in nude mice. These xenografts consisted of 3 hepatoid adenocarcinomas and 2 non-hepatoid, poorly differentiated adenocarcinomas. Mitomycin C and cisplatin inhibited the tumor growth and liver metastasis of hepatoid adenocarcinomas in nude mice. 5-fluorouracil also inhibited the growth of hepatoid adenocarcinomas but did not exhibit a significant antimetastatic action. Doxorubicin was effective only against non-hepatoid adenocarcinomas. These results indicate that chemotherapeutic drugs for AFPGC should be used according to the subtype of the tumor.
authors: YAMAGATA UNIV,SCH MED,DEPT PATHOL 2,YAMAGATA 99023,JAPAN.
authors: K
authors: K
authors: Aizawa
authors: T
authors: T
authors: Motoyama
authors: K
authors: K
authors: Ueki
authors: S
authors: S
authors: Suzuki
authors: N
authors: N
authors: Tanaka
authors: H
authors: H
authors: Yabusaki
authors: T
authors: T
authors: Suzuki
authors: K
authors: K
authors: Hatakeyama