title: Aberrant DNA methylation profile in cholangiocarcinoma.
abstract: Cholangiocarcinoma (CCA) is a notoriously lethal epithelial cancer originating from the biliary system. As radical resection offers a poor success rate and limited effective adjuvant modalities exist in its advanced stage, the disease leads to a fairly poor prognosis. As the incidence of CCA is increasing, although the mortality rate remains stable, and few other definite etiologies have yet to be established, renewing our knowledge of its fundamental carcinogenesis is advisable. The latest advances in molecular carcinogenesis have highlighted the roles of epigenetic perturbations and cancer-related inflammation in CCA. This review focuses on the reciprocal effects between aberrant DNA methylation and inflammatory microenvironment in CCA.
authors: Li Huang, Gabriel Frampton, Sharon DeMorrow, Department of Internal Medicine, Texas A&M Health Science Center College of Medicine, Temple, TX 76504, United States.
authors: Li
authors: L
authors: Huang
authors: Gabriel
authors: G
authors: Frampton
authors: Li-Jian
authors: LJ
authors: Liang
authors: Sharon
authors: S
authors: Demorrow
references: Science. 2009 Jan 30;323(5914):588-9
references: 19179515
references: Gastroenterology. 2007 Jan;132(1):384-96
references: 17241887
references: Oncogene. 2008 Jan 10;27(3):378-86
references: 17621267
references: CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
references: 19474385
references: Nature. 2008 Mar 6;452(7183):112-5
references: 18322535
references: Cancer Res. 2006 Nov 1;66(21):10517-24
references: 17079474
references: J Biol Chem. 2007 Mar 16;282(11):8256-64
references: 17220301
references: Cell Immunol. 2009;256(1-2):19-26
references: 19201396
references: Nat Rev Genet. 2007 Apr;8(4):286-98
references: 17339880
references: Mol Biol Cell. 1997 Dec;8(12):2407-19
references: 9398664
references: J Hepatobiliary Pancreat Surg. 2006;13(4):274-9
references: 16858537
references: J Surg Res. 1999 Jun 1;84(1):88-93
references: 10334895
references: Eur J Immunol. 2009 Mar;39(3):858-68
references: 19224634
references: Clin Cancer Res. 2007 Feb 1;13(3):902-11
references: 17289884
references: Lab Invest. 1999 Apr;79(4):477-83
references: 10212000
references: Nature. 2007 Feb 8;445(7128):671-5
references: 17268471
references: Asian Pac J Cancer Prev. 2009 Oct-Dec;10(4):575-82
references: 19827872
references: Semin Immunopathol. 2009 Sep;31(3):309-22
references: 19533132
references: J Clin Invest. 2007 Dec;117(12):3660-3
references: 18060028
references: Cancer Res. 2006 Jul 1;66(13):6622-7
references: 16818635
references: Hum Pathol. 2009 Jun;40(6):817-26
references: 19200577
references: J Am Coll Surg. 2009 Jan;208(1):134-47
references: 19228515
references: J Pathol. 2008 Jun;215(2):175-83
references: 18393368
references: Cancer Lett. 2005 Jan 20;217(2):213-9
references: 15617839
references: Nat Genet. 2009 Feb;41(2):178-186
references: 19151715
references: Gut. 1996 Apr;38(4):610-5
references: 8707097
references: Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14825-30
references: 16203990
references: Cancer Cell. 2008 Jan;13(1):7-9
references: 18167335
references: Gastroenterology. 2005 May;128(6):1655-67
references: 15887157
references: N Engl J Med. 2008 Mar 13;358(11):1148-59
references: 18337604
references: Science. 2009 Aug 28;325(5944):1142-6
references: 19696312
references: Liver Int. 2008 Jan;28(1):12-27
references: 18031477
references: Blood. 2008 May 15;111(10):5054-63
references: 18349319
references: Surg Oncol Clin N Am. 2002 Oct;11(4):995-1009
references: 12607585
references: Hepatology. 2009 Dec;50(6):2007-13
references: 19824076
references: Int J Cancer. 1998 Dec 9;78(6):695-8
references: 9833761
references: Chromosoma. 2009 Oct;118(5):549-65
references: 19506892
references: Life Sci. 2006 Apr 18;78(21):2494-502
references: 16336976
references: Oncology. 2001;60(2):151-61
references: 11244331
references: J Clin Invest. 2007 Dec;117(12):3988-4002
references: 18060036
references: Nature. 2008 Jun 12;453(7197):948-51
references: 18463634
references: J Surg Oncol. 2009 Nov 1;100(6):500-4
references: 19697355
references: J Pathol. 2009 Feb;217(3):442-51
references: 19025978
references: Int J Parasitol. 2005 May;35(6):591-6
references: 15862573
references: Hepatology. 2010 Jan;51(1):267-76
references: 19827165
references: J Clin Invest. 2007 Dec;117(12):3846-56
references: 18060032
references: Cancer Res. 1995 Jul 1;55(13):2756-60
references: 7796400
references: J Clin Invest. 2009 Jun;119(6):1524-36
references: 19411762
references: J Clin Invest. 2008 Oct;118(10):3331-42
references: 18802480
references: Nature. 2008 Mar 6;452(7183):45-50
references: 18322525
references: Nature. 2008 Jul 24;454(7203):436-44
references: 18650914
references: Biochim Biophys Acta. 2009 Sep;1790(9):925-35
references: 19328836
references: Gastroenterology. 2009 Sep;137(3):1138-50, 1150.e1-9
references: 19376120
references: Int J Cancer. 2000 Oct 15;88(2):228-31
references: 11004673
references: Am J Pathol. 2002 Sep;161(3):1015-22
references: 12213730
references: Gene. 2002 May 1;289(1-2):41-8
references: 12036582
references: Gastroenterology. 2005 Jun;128(7):2054-65
references: 15940637
references: Science. 2009 Feb 20;323(5917):1074-7
references: 19119186
references: World J Gastroenterol. 2007 Dec 28;13(48):6465-9
references: 18161915
references: Nucleic Acids Res. 2002 Nov 1;30(21):4634-42
references: 12409453
references: Lab Invest. 2003 Oct;83(10):1403-13
references: 14563942
references: Nat Rev Cancer. 2009 Feb;9(2):108-22
references: 19165226
references: Lung Cancer. 2005 Dec;50(3):299-307
references: 16125822
references: J Pathol. 2009 Apr;217(5):654-64
references: 19116990
references: J Biol Chem. 1997 Jun 6;272(23):14983-9
references: 9169472
references: Oncologist. 2008 Apr;13(4):415-23
references: 18448556
references: Cancer Res. 1998 Mar 15;58(6):1124-6
references: 9515793
references: Am J Pathol. 2006 Apr;168(4):1155-68
references: 16565491
references: Hum Pathol. 2004 Dec;35(12):1505-14
references: 15619210
references: Hepatology. 2005 Mar;41(3):506-16
references: 15726664
references: Hepatology. 2008 Jul;48(1):308-21
references: 18536057
references: Int J Cancer. 2002 Dec 1;102(4):366-71
references: 12402306
references: Trends Immunol. 2006 Sep;27(9):405-12
references: 16870508
references: Nat Genet. 2006 Dec;38(12):1378-85
references: 17072317
references: Hepatology. 1999 Nov;30(5):1128-33
references: 10534331
references: Proc Natl Acad Sci U S A. 2000 May 9;97(10):5237-42
references: 10805783
references: Cancer Metastasis Rev. 2009 Jun;28(1-2):167-76
references: 19160017
references: Cancer Res. 2008 Dec 15;68(24):10257-66
references: 19074894