title: Dietary inflammation factor rating system and risk of Alzheimer disease in elders.
abstract: It has been suggested that inflammation is involved in Alzheimer disease (AD) pathogenesis. The aim of this study is to evaluate the association between inflammatory aspects of diet and incident AD risk. About 2258 nondemented elderly (age ≥ 65) in New York who provided dietary information at baseline were followed-up prospectively for AD development. We examined the composite total Inflammation Factor Rating (tIFR), as a measure of inflammatory impact of foods, in relation with (i) serum level of high-sensitivity C-reactive protein (hsCRP) and (ii) risk of incident AD using Cox proportional hazard model. The tIFR was not associated with serum hsCRP level. After an average of 4.0 years of follow-up, 262 participants developed incident AD. The tIFR was not associated with AD risk: compared with the lowest tertile of tIFR (most proinflammatory), hazard ratios (95% confidence interval) for the highest tertile (most anti-inflammatory) was 0.97 (0.69-1.35) (P-for-trend=0.71), in the adjusted model. We conclude that tIFR might not be a biologically relevant measure of the inflammatory impact of the diet. In addition, although it remains possible that tIFR might be related with some other aspects of inflammation not captured by hsCRP, lack of association with AD risk suggests its limited clinical utility.
authors: Taub Institute for Research in Alzheimer's Disease and Aging Brain, Columbia University Medical Center, New York, NY 10032, USA.
authors: Yian
authors: Y
authors: Gu
authors: Jeri W
authors: JW
authors: Nieves
authors: Jose A
authors: JA
authors: Luchsinger
authors: Nikolaos
authors: N
authors: Scarmeas
references: J Lipid Res. 1990 Mar;31(3):545-8
references: 2341813
references: Clin Chem Lab Med. 2008;46(7):990-6
references: 18605965
references: Circulation. 2008 Jan 15;117(2):169-75
references: 18086924
references: Eur J Nutr. 2005 Sep;44(6):348-54
references: 16151968
references: Neurology. 2005 Apr 26;64(8):1371-7
references: 15851726
references: J Am Geriatr Soc. 2004 Apr;52(4):540-6
references: 15066068
references: Eur J Clin Nutr. 2008 May;62(5):651-9
references: 17440519
references: N Engl J Med. 2004 Jul 1;351(1):56-67
references: 15229308
references: Neurobiol Aging. 2000 May-Jun;21(3):383-421
references: 10858586
references: Aust N Z J Public Health. 1998 Jun;22(4):456-63
references: 9659773
references: Neurobiol Aging. 2007 Dec;28(12):1810-20
references: 17011077
references: Maturitas. 2002 Apr 25;41(4):313-9
references: 12034518
references: Neurology. 2002 Aug 13;59(3):371-8
references: 12177370
references: Curr Opin Investig Drugs. 2004 Jul;5(7):706-13
references: 15298065
references: Neurology. 2003 Jul 8;61(1):76-80
references: 12847160
references: JAMA. 2004 Jun 23;291(24):2947-58
references: 15213206
references: J Chronic Dis. 1987;40(5):373-83
references: 3558716
references: Int Psychogeriatr. 2008 Feb;20(1):47-56
references: 18072983
references: Am J Clin Nutr. 2008 Jul;88(1):185-94
references: 18614740
references: Neurology. 2000 Feb 22;54(4):833-7
references: 10690972
references: Curr Neurol Neurosci Rep. 2007 Sep;7(5):366-72
references: 17764625
references: Arch Neurol. 2002 Aug;59(8):1258-63
references: 12164721
references: J Am Coll Cardiol. 2004 Jul 7;44(1):152-8
references: 15234425
references: Ann Neurol. 2006 Jun;59(6):912-21
references: 16622828
references: Cytokine. 2009 Jan;45(1):44-9
references: 19058974
references: Am J Clin Nutr. 2004 Oct;80(4):1029-35
references: 15447916
references: Clin Chem. 2009 Feb;55(2):256-64
references: 19074515
references: Arch Neurol. 2003 Feb;60(2):203-8
references: 12580704
references: JAMA. 2004 Sep 22;292(12):1440-6
references: 15383514
references: Neurology. 1995 Mar;45(3 Pt 1):555-7
references: 7898715
references: Am J Epidemiol. 1985 Jul;122(1):51-65
references: 4014201
references: Ann Neurol. 2002 Aug;52(2):168-74
references: 12210786
references: J Nutr. 2007 Apr;137(4):992-8
references: 17374666
references: Neurology. 1984 Jul;34(7):939-44
references: 6610841
references: Cardiol Clin. 2003 Aug;21(3):315-25
references: 14621448
references: Arch Med Res. 2008 Jan;39(1):1-16
references: 18067990
references: J Alzheimers Dis. 2007 Jul;11(4):457-63
references: 17656824
references: Neurology. 2007 May 29;68(22):1902-8
references: 17536046
references: Arch Neurol. 2004 May;61(5):668-72
references: 15148142
references: Arch Neurol. 1992 May;49(5):453-60
references: 1580806
references: Ann N Y Acad Sci. 2009 Feb;1153:240-6
references: 19236346
references: J Neuroimmunol. 2003 Jan;134(1-2):142-50
references: 12507782
references: Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1026-32
references: 19336550
references: Am J Epidemiol. 1986 Jul;124(1):17-27
references: 3521261
references: Inflamm Res. 2005 May;54(5):194-203
references: 15953991
references: Arch Neurol. 2005 Oct;62(10):1601-8
references: 16216946