title: Formal synthesis of leustroducsin B via Reformatsky/Claisen condensation of silyl glyoxylates.
abstract: A formal synthesis of leustroducsin B has been completed. The synthesis relies upon a recently developed Reformatsky/Claisen condensation of silyl glyoxylates and enantioenriched β-lactones that establishes two of the molecule's three core stereocenters and permits further elaboration to an intermediate in Imanishi's synthesis via reliable chemistry (Prasad reduction, asymmetric pentenylation, Mitsunobu inversion).
authors: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
authors: Stephen N
authors: SN
authors: Greszler
authors: Justin T
authors: JT
authors: Malinowski
authors: Jeffrey S
authors: JS
authors: Johnson
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