title: Tibrogargan and Coastal Plains rhabdoviruses: genomic characterization, evolution of novel genes and seroprevalence in Australian livestock.
abstract: Tibrogargan virus (TIBV) and Coastal Plains virus (CPV) were isolated from cattle in Australia and TIBV has also been isolated from the biting midge Culicoides brevitarsis. Complete genomic sequencing revealed that the viruses share a novel genome structure within the family Rhabdoviridae, each virus containing two additional putative genes between the matrix protein (M) and glycoprotein (G) genes and one between the G and viral RNA polymerase (L) genes. The predicted novel protein products are highly diverged at the sequence level but demonstrate clear conservation of secondary structure elements, suggesting conservation of biological functions. Phylogenetic analyses showed that TIBV and CPV form an independent group within the 'dimarhabdovirus supergroup'. Although no disease has been observed in association with these viruses, antibodies were detected at high prevalence in cattle and buffalo in northern Australia, indicating the need for disease monitoring and further study of this distinctive group of viruses.
authors: Commonwealth Scientific and Industrial Research Organisation (CSIRO) Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia.|Human Protection and Performance Division, Defence Science and Technology Organisation, Melbourne, Australia.|School of Chemistry and Molecular Sciences, University of Queensland, St Lucia, Queensland, Australia.|Australian Biosecurity Cooperative Research Centre for Emerging Infectious Disease, Brisbane, Queensland, Australia.
authors: Aneta
authors: A
authors: Gubala
authors: Northern Territory Department of Resources, Berrimah Veterinary Laboratories, Berrimah, Northern Territory, Australia.
authors: Steven
authors: S
authors: Davis
authors: Australian Biosecurity Cooperative Research Centre for Emerging Infectious Disease, Brisbane, Queensland, Australia.|Northern Territory Department of Resources, Berrimah Veterinary Laboratories, Berrimah, Northern Territory, Australia.
authors: Richard
authors: R
authors: Weir
authors: Australian Biosecurity Cooperative Research Centre for Emerging Infectious Disease, Brisbane, Queensland, Australia.|Northern Territory Department of Resources, Berrimah Veterinary Laboratories, Berrimah, Northern Territory, Australia.
authors: Lorna
authors: L
authors: Melville
authors: Australian Biosecurity Cooperative Research Centre for Emerging Infectious Disease, Brisbane, Queensland, Australia.|Commonwealth Scientific and Industrial Research Organisation (CSIRO) Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
authors: Chris
authors: C
authors: Cowled
authors: Australian Biosecurity Cooperative Research Centre for Emerging Infectious Disease, Brisbane, Queensland, Australia.|Commonwealth Scientific and Industrial Research Organisation (CSIRO) Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
authors: David
authors: D
authors: Boyle