title: Depression, disability and cognitive impairment in multiple sclerosis: a cross sectional Italian study.
abstract: The disability, cognitive impairment, fatigue and depression are interacting features in multiple sclerosis (MS), whose relation is still unclear. The objective of this study was to evaluate in a sample of MS patients, the frequency of depressive symptoms, its predicting factors and relation with cognitive impairment, fatigue and disability. 255 consecutive MS patients and 166 healthy subjects were assessed for the presence of depressive symptoms with the Beck Depression Inventory-Fast Screen (BDI-FS). Patients with BDI-FS ≥ 4 were further investigated for the presence of neuropsychological impairment. Depressive symptoms were significantly more frequent and severe in patients than in controls. EDSS score was the only predicting factor of depression (3.5 = threshold EDSS score for depressive symptoms) in patients, whereas neuropsychological impairment was not correlated with BDI-FS and fatigue was found to be significantly correlated with attention, executive function and memory test scores, as well as with BDI-FS score in patients.
authors: Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka 13, 25123 Brescia, Italy. flaviacaterina.mattioli@gmail.com
authors: Flavia
authors: F
authors: Mattioli
authors: Fabio
authors: F
authors: Bellomi
authors: Chiara
authors: C
authors: Stampatori
authors: Giovanni
authors: G
authors: Parrinello
authors: Ruggero
authors: R
authors: Capra
references: Neurology. 2000 Oct 10;55(7):934-9
references: 11061247
references: J Int Neuropsychol Soc. 2006 Jul;12(4):549-58
references: 16981607
references: J Neurol. 2008 Jun;255(6):910-6
references: 18484237
references: Mult Scler. 2000 Apr;6(2):115-20
references: 10773857
references: Mult Scler. 2003 Jun;9(3):284-8
references: 12814176
references: Cogn Neuropsychiatry. 2003 Aug;8(3):161-71
references: 16571558
references: Expert Rev Neurother. 2005 May;5(3):413-20
references: 15938674
references: Acta Psychiatr Scand. 1994 Feb;89(2):117-21
references: 8178661
references: J Nerv Ment Dis. 1992 Nov;180(11):730-2
references: 1431826
references: Arch Neurol. 1987 Apr;44(4):376-8
references: 3827692
references: J Int Neuropsychol Soc. 2008 Sep;14(5):691-724
references: 18764967
references: J Clin Exp Neuropsychol. 1986 Oct;8(5):503-42
references: 3805250
references: Lancet Neurol. 2008 Dec;7(12):1139-51
references: 19007738
references: Mult Scler. 2001 Oct;7(5):340-4
references: 11724451
references: Clin Infect Dis. 1994 Jan;18 Suppl 1:S79-83
references: 8148458
references: Ann Neurol. 2005 Dec;58(6):840-6
references: 16283615
references: J Neurol Neurosurg Psychiatry. 1992 Jul;55(7):542-5
references: 1640228
references: Gen Hosp Psychiatry. 1987 Nov;9(6):426-34
references: 3692149
references: Disabil Rehabil. 2006 Jun 30;28(12):779-88
references: 16754575
references: Mult Scler. 2005 Aug;11(4):469-76
references: 16042232
references: J Clin Exp Neuropsychol. 1997 Dec;19(6):810-24
references: 9524876
references: Neurology. 1983 Nov;33(11):1444-52
references: 6685237
references: Arch Neurol. 1990 Jan;47(1):94-7
references: 2403789
references: J Neurol. 2001 May;248(5):416-21
references: 11437165
references: J Clin Exp Neuropsychol. 1994 Apr;16(2):183-9
references: 8021305
references: Am J Alzheimers Dis Other Demen. 2002 Jan-Feb;17(1):23-9
references: 11831417
references: Acta Neurol Scand. 2007 Jan;115(1):67-72
references: 17156268
references: Neurology. 1991 May;41(5):685-91
references: 2027484
references: J Neurol Sci. 2004 Feb 15;217(2):211-6
references: 14706226
references: Mult Scler. 2001 Dec;7(6):411-6
references: 11795464
references: Mult Scler. 2003 Aug;9(4):393-6
references: 12926845
references: Neurology. 2003 Dec 9;61(11):1524-7
references: 14663036
references: Curr Opin Neurol. 2003 Jun;16(3):283-8
references: 12858063