title: [Genetic variations of bone morphogenetic protein 7 gene are associated with hypertriglyceridemia of Uygur Chinese in Xinjiang].
abstract: OBJECTIVE
  To analyze the association between the genetic variations of functional region in bone morphogenetic protein (BMP7) gene and dyslipidemia in Chinese Uygur individuals.
  
  
  METHODS
  The case-control study was conducted in 1514 Uygur Chinese based on epidemiological investigation. The all exons, segmental introns and the promoter regions of BMP7 gene were sequenced in 48 out of 1514 Uygur Chinese. Representative variations were then selected according to the minor allele frequency (MAF) and linkage disequilibrium, and genotyped using the TaqMan polymerase chain reaction method in 1514 Uygur Chinese, a relatively isolated general population in a relatively homogeneous environment, to observe the association between genetic variations of BMP7 gene and dyslipidemia.
  
  
  RESULTS
  Five novel and eight known variations in the BMP7 gene were identified. All genotype distributions were tested for deviations from Hardy-Weinberg equilibrium. There were significant differences of genotype distribution of rs6025422 between hypertriglyceridemia group and control group (P = 0.001). The levels of triglyceride (TG) showed a decreasing tendency in individuals with AA, AG and GG genotypes of rs6025422. Odd ratio (OR) value adjusted for age, gender, body mass index, smoking and alcohol drinking habits was 0.562 by logistic regression analysis (95%CI: 0.393 - 0.802, P = 0.002).
  
  
  CONCLUSIONS
  The present study shows rs6025422 polymorphism in the BMP7 gene is linked with hypertriglyceridemia phenotype in Uygur Chinese population.
authors: Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, Department of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China.
authors: Zhi-Tao
authors: ZT
authors: Yan
authors: Nan-Fang
authors: NF
authors: Li
authors: Yan-Ying
authors: YY
authors: Guo
authors: Xiao-Guang
authors: XG
authors: Yao
authors: Hong-Mei
authors: HM
authors: Wang
authors: Wen-Li
authors: WL
authors: Luo
authors: Ju-Hong
authors: JH
authors: Zhang
authors: Jing
authors: J
authors: Hong
authors: Ling
authors: L
authors: Zhou