title: Computational assessment of insulin secretion and insulin sensitivity from 2-h oral glucose tolerance tests for clinical use for type 2 diabetes.
abstract: In type 2 diabetes mellitus, glucose homeostasis is tightly maintained through insulin secretion and insulin sensitivity. Therefore, finding an accurate method to assess insulin secretion and sensitivity using clinically available data would enhance the quality of diabetic medical care. In an effort to find such a method, we developed a computational approach to derive indices of these factors using a 2-h oral glucose tolerance test (OGTT). To evaluate our method, clinical data from subjects who received an OGTT and a glucose clamp test were examined. Our insulin secretion index was significantly correlated with an analogous index obtained from a hyperglycemic clamp test (r = 0.90, n = 46, p < 0.001). Our insulin sensitivity index sensitivity was also significantly correlated with an analogous index obtained from a hyperinsulinemic-euglycemic clamp test (r = 0.56, n = 79, p < 0.001). These results suggest that our method can potentially provide an accurate and convenient tool toward improving the management of diabetes in clinical practice by assessing insulin secretion and insulin sensitivity.
authors: Central Research Laboratories, Sysmex Corporation, Takatsukadai, Nishi-ku, Kobe, Japan.
authors: Masayoshi
authors: M
authors: Seike
authors: Takeo
authors: T
authors: Saitou
authors: Yasuhiro
authors: Y
authors: Kouchi
authors: Takeshi
authors: T
authors: Ohara
authors: Munehide
authors: M
authors: Matsuhisa
authors: Kazuhiko
authors: K
authors: Sakaguchi
authors: Koji
authors: K
authors: Tomita
authors: Keisuke
authors: K
authors: Kosugi
authors: Atsunori
authors: A
authors: Kashiwagi
authors: Masato
authors: M
authors: Kasuga
authors: Masaru
authors: M
authors: Tomita
authors: Yasuhiro
authors: Y
authors: Naito
authors: Hiromu
authors: H
authors: Nakajima
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