title: Structure-activity relationship for quaternary ammonium compounds hybridized with poly(methyl methacrylate).
abstract: Hybrid films from poly (methylmethacrylate) (PMMA) and dioctadecyldimethylammonium bromide (DODAB), cetyltrimethylammonium bromide (CTAB), or tetrapropylammonium bromide (TPAB) were characterized by determination of wettability, ellipsometry, atomic force microscopy, active compounds diffusion to water, X-ray photoelectron spectroscopy (XPS) with determination of atomic composition on the films surface, and biocidal activity against Pseudomonas aeruginosa or Staphylococcus aureus. QAC mobility in the films increased from DODAB to CTAB to TPAB. Diffusion and optimal hydrophobic-hydrophilic balance imparted the highest bioactivity to CTAB. DODAB sustained immobilization at the film surface killed bacteria upon contact. TPAB ability to diffuse was useless because of its unfavorable hydrophobic-hydrophilic balance for bioactivity.
authors: Biocolloids Lab, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05513-970, São Paulo/SP, Brazil.
authors: Leticia D
authors: LD
authors: Melo
authors: Renata R
authors: RR
authors: Palombo
authors: Denise F S
authors: DF
authors: Petri
authors: Michael
authors: M
authors: Bruns
authors: Edla M A
authors: EM
authors: Pereira
authors: Ana M
authors: AM
authors: Carmona-Ribeiro