title: Up-beat UK: a programme of research into the relationship between coronary heart disease and depression in primary care patients.
abstract: BACKGROUND
  Coronary heart disease and depression are both common health problems and by 2020 will be the two leading causes of disability worldwide. Depression has been found to be more common in patients with coronary heart disease but the nature of this relationship is uncertain. In the United Kingdom general practitioners are now being remunerated for case-finding for depression in patients with coronary heart disease, however it is unclear how general practitioners should manage these patients. We aim to explore the relationship between coronary heart disease and depression in a primary care population and to develop an intervention for patients with coronary heart disease and depression.
  
  
  METHODS
  This programme of research will consist of 4 inter-related studies. A 4 year prospective cohort study of primary care patients with coronary heart disease will be conducted to explore the relationship between coronary heart disease and depression. Within this, a nested case-control biological study will investigate genetic and blood-biomarkers as predictors of depression in this sample. Two qualitative studies, one of patients' perspectives of treatments for coronary heart disease and co-morbid depression and one of primary care professionals' views on the management of patients with coronary heart disease and depression will inform the development of an intervention for this patient group. A feasibility study for a randomised controlled trial will then be conducted.
  
  
  CONCLUSIONS
  This study will provide information on the relationship between coronary heart disease and depression that will allow health services to determine the efficiency of case-finding for depression in this patient group. The results of the cohort study will also provide information on risk factors for depression. The study will provide evidence on the efficacy and feasibility of a joint patient and professional led intervention and data necessary to plan a definitive randomised controlled trial of the intervention.
authors: Health Services and Population Research Dept., Institute of Psychiatry, King's College London, UK. a.tylee@iop.kcl.ac.uk
authors: André
authors: A
authors: Tylee
authors: Mark
authors: M
authors: Ashworth
authors: Elizabeth
authors: E
authors: Barley
authors: June
authors: J
authors: Brown
authors: John
authors: J
authors: Chambers
authors: Anne
authors: A
authors: Farmer
authors: Zoe
authors: Z
authors: Fortune
authors: Mark
authors: M
authors: Haddad
authors: Rebecca
authors: R
authors: Lawton
authors: Anthony
authors: A
authors: Mann
authors: Anita
authors: A
authors: Mehay
authors: Paul
authors: P
authors: McCrone
authors: Joanna
authors: J
authors: Murray
authors: Morven
authors: M
authors: Leese
authors: Carmine M
authors: CM
authors: Pariante
authors: Diana
authors: D
authors: Rose
authors: Gill
authors: G
authors: Rowlands
authors: Alison
authors: A
authors: Smith
authors: Paul
authors: P
authors: Walters
references: Med Care. 1996 Mar;34(3):220-33
references: 8628042
references: JAMA. 2003 Jun 18;289(23):3106-16
references: 12813116
references: BMJ. 2006 Apr 29;332(7548):1030-2
references: 16644834
references: Br J Soc Clin Psychol. 1967 Dec;6(4):278-96
references: 6080235
references: Acta Psychiatr Scand. 1983 Jun;67(6):361-70
references: 6880820
references: Psychosom Med. 2006 Sep-Oct;68(5):645-50
references: 17012516
references: Psychosom Med. 2004 Jul-Aug;66(4):466-74
references: 15272090
references: Arch Gen Psychiatry. 2005 Jul;62(7):792-8
references: 15997021
references: Bull World Health Organ. 1962;27:645-58
references: 13974778
references: J Gen Intern Med. 2001 Sep;16(9):606-13
references: 11556941
references: Med Care. 2003 Nov;41(11):1284-92
references: 14583691
references: Acta Psychiatr Scand. 1990 Jul;82(1):77-81
references: 2399824
references: Heart. 1997 Aug;78(2):142-6
references: 9326987
references: BMJ. 2001 Oct 27;323(7319):948-9
references: 11679372
references: Psychol Med. 1985 Aug;15(3):637-49
references: 4048322
references: Fam Med. 1993 Jun;25(6):391-5
references: 8349060
references: Psychosom Med. 2008 May;70(4):450-5
references: 18434496
references: Ann Med. 2001 Jul;33(5):337-43
references: 11491192
references: JAMA. 2002 Aug 14;288(6):701-9
references: 12169073
references: Gen Hosp Psychiatry. 2003 May-Jun;25(3):158-68
references: 12748028
references: J Psychosom Res. 2006 Jun;60(6):631-7
references: 16731240
references: Circulation. 1981 Dec;64(6):1227-34
references: 7296795
references: Psychol Med. 2006 Jan;36(1):7-14
references: 16356292
references: Br J Psychiatry. 2006 May;188:449-52
references: 16648531
references: Int J Cardiol. 2001 May;78(3):257-64
references: 11376829
references: Health Qual Life Outcomes. 2007 Nov 27;5:63
references: 18042300
references: J Epidemiol Community Health. 1994 Apr;48(2):207-10
references: 8189180
references: Lancet. 1997 May 24;349(9064):1498-504
references: 9167458
references: Med Care. 1986 Jan;24(1):67-74
references: 3945130