title: Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population.
abstract: We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the pro-inflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.
authors: The Veterans Administration Center for AIDS and HIV-1 infection and Center for Personalized Medicine, South Texas Veterans Health Care System and Department of Medicine, University of Texas Health Science Center, San Antonio, USA.
authors: Manju
authors: M
authors: Mamtani
authors: Srinivas
authors: S
authors: Mummidi
authors: Veron
authors: V
authors: Ramsuran
authors: Minh-Hieu
authors: MH
authors: Pham
authors: Robert
authors: R
authors: Maldonado
authors: Kazi
authors: K
authors: Begum
authors: Maria Soledad
authors: MS
authors: Valera
authors: Racquel
authors: R
authors: Sanchez
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authors: Castiblanco
authors: Hemant
authors: H
authors: Kulkarni
authors: Thumbi
authors: T
authors: Ndung'u
authors: Weijing
authors: W
authors: He
authors: Juan Manuel
authors: JM
authors: Anaya
authors: Sunil K
authors: SK
authors: Ahuja
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