title: Analysis of somatic hypermutations of immunoglobulin gene rearrangements in childhood acute lymphoblastic leukemia.
abstract: The current study investigated the presence, frequency, and status of somatic hypermutations as well as their role in children with B lineage ALL. The obtained sequences were analyzed using IMGT/V-QUEST. Totally, 150 IGH sequences were evaluated; 139 from the 111 patients at the time of diagnosis and 11 from 8/111 patients at the time of relapse. The findings of the current report revealed the presence of somatically mutated V genes in childhood B lineage ALL. A higher frequency of somatic hypermutations was noted in unproductive rearrangements and was generally attributed to nucleotide mutation type, region, and IGHV gene subgroup biases.
authors: University Research Institute for the Study and Treatment of Childhood Genetic and Malignant Diseases, Hematology/Oncology Unit, First Department of Pediatrics, Aghia Sophia Children's Hospital, University of Athens, Athens, Greece. mbraouda@yahoo.co.uk
authors: M
authors: M
authors: Braoudaki
authors: K
authors: K
authors: Katsibardi
authors: V
authors: V
authors: Giudicelli
authors: K
authors: K
authors: Karamolegou
authors: Ch
authors: Ch
authors: Papathanassiou
authors: M-P
authors: MP
authors: Lefranc
authors: F
authors: F
authors: Tzortzatou-Stathopoulou