title: An atypical subtrochanteric femoral fracture from pycnodysostosis: a lesson from nature.
abstract: This case describes a man with an unusual cause of an atypical subtrochanteric fracture, pycnodysostosis. This condition results from mutations involving the cathepsin K gene. New antiresorptive treatments for osteoporosis inhibit the cathepsin K enzyme in osteoclasts. Therefore, there should be vigilant monitoring for the development of long-term complications noted to occur in diseases of reduced osteoclast function, including pycnodysostosis, in patients receiving these novel antiresorptive agents.
authors: Endocrinology Unit, University of Melbourne, Western Hospital, Footscray, Victoria, Australia.
authors: Christopher J
authors: CJ
authors: Yates
authors: Miriam J
authors: MJ
authors: Bartlett
authors: Peter R
authors: PR
authors: Ebeling