title: Preparation and characterization of highly stable lipid nanoparticles with amorphous core of tuneable viscosity.
abstract: Lipid nanoparticles (LNP) have been designed based on low cost and human-use approved excipients, and manufactured by an easy, robust, and up-scalable process. Fluid colloidal dispersions or gel viscous formulations of highly stable nanoparticles (more than 12 month stability is achieved for some formulations) can be obtained. Their physicochemical properties are studied by Dynamic Light Scattering, Differential Scanning Calorimetry, and NMR. The results picture nanoparticles with a non-crystalline core, which viscosity can be finely tuned by the lipid composition and the temperature. A design of experiments has been used to investigate the limits of the system colloidal stability. The impact of core and surfactant weight fractions have been explored both experimentally and using the design of experiments. The versatility of this physicochemical system could open the way to a wide range of future pharmaceutical applications.
authors: CEA, LETI-MINATEC, Département des Technologies pour la Biologie et la Santé, 17 rue des Martyrs, F-38054 Grenoble, France.
authors: Thomas
authors: T
authors: Delmas
authors: Anne-Claude
authors: AC
authors: Couffin
authors: Pierre Alain
authors: PA
authors: Bayle
authors: François
authors: F
authors: de Crécy
authors: Emmanuelle
authors: E
authors: Neumann
authors: Françoise
authors: F
authors: Vinet
authors: Michel
authors: M
authors: Bardet
authors: Jérôme
authors: J
authors: Bibette
authors: Isabelle
authors: I
authors: Texier