title: Stereoselective synthesis of E,Z-configured 1,3-dienes by ring-closing metathesis. Application to the total synthesis of lactimidomycin.
abstract: Strategic positioning of a silyl group on the diene unit of a diene-ene substrate allows rigorous regio- and stereocontrol to be exerted during metathesis-based macrocyclization reactions. The versatility of this concise approach to E,Z-configured 1,3-dienes of ring sizes of 12 or larger is demonstrated by an application to the total synthesis of lactimidomycin, a potent translation and cell-migration inhibitor.
authors: Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim/Ruhr, Germany.
authors: Daniel
authors: D
authors: Gallenkamp
authors: Alois
authors: A
authors: Fürstner