title: Treatment of auditory verbal hallucinations with transcranial magnetic stimulation in a patient with psychotic major depression: one-year follow-up.
abstract: Auditory verbal hallucinations (AVH) in patients with schizophrenia can respond to repetitive transcranial magnetic stimulation (TMS). We report the therapeutic utility of rTMS in a 48-year-old patient with a 20-year history of severe depression (five suicidal gestures and previous failure of ECT) and internal AVH. First, 20 Hz rTMS to the left prefrontal cortex for 3 weeks significantly improved depression (BDI-II: 89% change, lasting 14 months along with weekly/bi-weekly maintenance treatments), but AVH remained unchanged. The patient also underwent a further course of the left temporo-parietal 1 Hz rTMS and amelioration of AVH severity was achieved (PSYRATS-AH: 53% change) and maintained at 1-year follow-up. AVH respond to rTMS in disorders other than schizophrenia. Furthermore, targeted rTMS to different brain regions can address diverse symptoms in neuropsychiatric conditions.
authors: Berenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
authors: Catarina
authors: C
authors: Freitas
authors: Chester
authors: C
authors: Pearlman
authors: Alvaro
authors: A
authors: Pascual-Leone
references: Biol Psychiatry. 2007 Dec 1;62(11):1208-16
references: 17573044
references: Schizophr Bull. 2010 May;36(3):633-41
references: 18849293
references: Electroencephalogr Clin Neurophysiol. 1994 Aug;91(2):79-92
references: 7519144
references: Am J Psychiatry. 2002 Nov;159(11):1855-61
references: 12411219
references: Schizophr Res. 2009 Mar;108(1-3):11-24
references: 19138833
references: Brain. 2009 Nov;132(Pt 11):2994-3001
references: 19620178
references: Schizophr Res. 2009 Oct;114(1-3):172-9
references: 19679450
references: Am J Psychiatry. 2002 Jul;159(7):1093-102
references: 12091184
references: Arch Gen Psychiatry. 2010 May;67(5):507-16
references: 20439832
references: Psychol Med. 2009 Jan;39(1):65-75
references: 18447962
references: Am J Psychiatry. 2008 Apr;165(4):537-8
references: 18381921
references: Biol Psychiatry. 1999 Jul 1;46(1):130-2
references: 10394483
references: Biol Psychiatry. 2002 Jul 1;52(1):24-31
references: 12079727
references: PLoS One. 2009 Aug 21;4(8):e6725
references: 19696930
references: J Clin Psychiatry. 2008 Aug;69(8):1293-6
references: 18384244
references: Cogn Neuropsychiatry. 2006 Jan;11(1):65-83
references: 16537234
references: Brain. 2008 Dec;131(Pt 12):3169-77
references: 18854323
references: Schizophr Res. 2007 Jul;93(1-3):406-8
references: 17478084
references: Cereb Cortex. 2007 Nov;17(11):2733-43
references: 17298962
references: Soc Psychiatry Psychiatr Epidemiol. 1991 Dec;26(6):287-92
references: 1792560
references: Cochrane Database Syst Rev. 2004;(1):CD003012
references: 14974002
references: Schizophr Bull. 2011 Sep;37(5):1009-16
references: 20164122
references: Neuroreport. 2004 Jul 19;15(10):1669-73
references: 15232304
references: J Clin Neurophysiol. 1998 Jul;15(4):333-43
references: 9736467
references: Cogn Behav Neurol. 2010 Mar;23(1):29-38
references: 20299861
references: Br J Soc Clin Psychol. 1967 Dec;6(4):278-96
references: 6080235
references: Compr Psychiatry. 2008 Sep-Oct;49(5):421-9
references: 18702928
references: Acta Psychiatr Scand. 2007 Sep;116(3):165-73
references: 17655557
references: Psychol Med. 1999 Jul;29(4):879-89
references: 10473315
references: Schizophr Res. 2009 Aug;113(1):77-83
references: 19505799
references: J Neurosci. 2001 Aug 1;21(15):RC157
references: 11459878
references: Arch Gen Psychiatry. 1976 Jun;33(6):766-71
references: 938196
references: Arch Gen Psychiatry. 2000 Nov;57(11):1033-8
references: 11074868
references: BMC Neurol. 2008 Jun 20;8:21
references: 18570642
references: J Clin Psychopharmacol. 2005 Aug;25(4):358-62
references: 16012279
references: Neuroimage. 2010 Aug 15;52(2):436-44
references: 20438853
references: J Neurosci. 2008 Nov 5;28(45):11435-44
references: 18987180
references: Brain. 2000 Apr;123 ( Pt 4):733-45
references: 10734005
references: Br J Psychiatry. 2002 Feb;180:174-8
references: 11823331
references: Nature. 1995 Nov 9;378(6553):176-9
references: 7477318
references: Biol Psychiatry. 2003 Apr 15;53(8):680-90
references: 12706954
references: Arch Gen Psychiatry. 2003 Jan;60(1):49-56
references: 12511172
references: Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):18035-40
references: 19004769
references: Biol Psychiatry. 2005 Jul 15;58(2):97-104
references: 15936729