title: The structural and biological properties of hydroxyapatite-modified titanate nanowire scaffolds.
abstract: Hydroxyapatite-modified titanate nanowire scaffolds as alternative materials for tissue engineering have been developed via a titanate nanowire matrix assisted electrochemical deposition method. The macroporous titanate nanowire matrix on Ti metal was fabricated by a hydrothermal method, and then followed by an electrochemical synthesis of hydroxyapatite nanoparticles on titanate nanowire. The incorporation of titanate nanowire matrix with high oriented hydroxyapatite nanoparticles generates hierarchical scaffolds with highly osteogenic, structural integrity and excellent mechanical performance. As-prepared porous three dimensional interconnected hydroxyapatite-modified titanate nanowire scaffolds, mimicking the nature's extracellular matrix, could provide a suitable microenvironment for tissue cell ingrowth and differentiation. The ceramic titanate nanowire core with HA nanoparticle sheath structure displays superhydrophilicity, which facilitates the cell attachment and proliferation, and induces the in vitro tissue-engineered bone. Human osteoblast-like MG63 cells were cultured on the hydroxyapatite-modified titanate nanowire scaffolds, and the results showed that the scaffolds highly promote the bioactivity, osteoconductivity and osteoblast differentiation.
authors: Center for Optoelectronics Materials and Devices, Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, Zhejiang Sci-Tech University, Hangzhou, PR China.
authors: Haixin
authors: H
authors: Zhao
authors: Wenjun
authors: W
authors: Dong
authors: Yingying
authors: Y
authors: Zheng
authors: Aiping
authors: A
authors: Liu
authors: Juming
authors: J
authors: Yao
authors: Chaorong
authors: C
authors: Li
authors: Weihua
authors: W
authors: Tang
authors: Benyong
authors: B
authors: Chen
authors: Ge
authors: G
authors: Wang
authors: Zhan
authors: Z
authors: Shi