title: [Thyroid cancer in Iceland. Epidemiology and prognostic factors with special emphasis on the results of nuclear DNA-analysis].
abstract: All malignant primary tumours of the thyroid gland in Iceland during the 36 years 1955 to 1990 were studied. In all 494 thyroid carcinomas were diagnosed during that period. A considerable increase in the reported incidence of thyroid cancer was noted around 1965 and a decline around 1980. These changes are mainly due to variability in incidence of papillary carcinomas in females. The survival rate corrected for intercurrent death was similar for both papillary and follicular carcinomas. During the observation period there was a decline in mortality rate for this disease. In this study we also analysed if DNA-ploidy status and S-phase fraction had an effect on the prognosis of patients with carcinoma of the thyroid gland. By analysing tumour material from paraffin blocks we were able to evaluate the ploidy status in 424 tumours and S-phase value in 417 tumours. Univariate analysis showed that both the ploidy status and the S-phase fraction gave significant values. When taking into account known prognostic variables of thyroid carcinoma in a multivariate analysis neither the ploidy status nor the S-phase value proved significant.
authors: J
authors: J
authors: Hrafnkelsson
authors: J G
authors: JG
authors: Jonasson