title: High-density glycosylation of polymer membrane surfaces by click chemistry for carbohydrate-protein recognition.
abstract: To biologically mimic the carbohydrate-protein interactions in artificial systems, one of the challenges is to construct a glycosylated surface with a high glycosyl density to yield a notable 'glycoside cluster effect'. A novel strategy is presented for high density glycosylation of the surface of a microporous poly(propylene) membrane (MPPM) by click chemistry. It is promising that the surface glycosyl density can be well controlled over a wide range and the maximum value is over 10 µmol · cm(-2) . The recognition capability of these glycosylated MPPMs to lectins indicates the occurrence of the 'glycoside cluster effect' when the glycosyl density on the membrane surface exceeds 0.20 µmol · cm(-2) .
authors: Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
authors: Cang
authors: C
authors: Wang
authors: Jian
authors: J
authors: Wu
authors: Zhi-Kang
authors: ZK
authors: Xu