title: Serum intracellular adhesion molecule-1 (sicam-1) and soluble hla class-1 antigens in breast-cancer patients in relation to tumor burden.
abstract: sICAM-1 and beta-2 microglobulin (beta-2M) serum levels were measured in 143 breast cancer patients and 43 controls. The patients were divided into three groups. A: new patients; B: patients on long term follow-up and C: metastatic patients. In all patients the mean +/-1SD sICAM-1 and beta-2M serum levels were significantly higher than normal controls (p <0.001 and p <0.0001, respectively). Analysis of the three groups showed that for both sICAM-1 and beta-2M, Groups A and C had similar serum levels, which differed significantly from Group B. sICAM-1 of Group B was similar to controls, while beta-2M of Group B was significantly higher than controls. During the study 20 patients relapsed. Initial high levels of sICAM-1 were observed in 20% and beta-2M in 50% of patients. These data suggest that sICAM-1 and beta-2M level indicate host cell-mediated immunity against tumor.
authors: SOROKA HOSP,DEPT UROL,BEER SHEVA,ISRAEL. BEILINSON MED CTR,TISSUE TYPING LAB,IL-49100 PETAH TIQWA,ISRAEL. MEIR HOSP,ONCOL UNIT,KEFAR SAVA,ISRAEL. BEILINSON MED CTR,DEPT ONCOL,IL-49100 PETAH TIQWA,ISRAEL. GOLDA MEIR MED CTR,ONCOL UNIT,PETAH TIQWA,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL.
authors: I
authors: I
authors: Levin
authors: T
authors: T
authors: Klein
authors: Y
authors: Y
authors: Shapira
authors: H
authors: H
authors: Lurie
authors: B
authors: B
authors: Kfir
authors: R
authors: R
authors: Narinsky
authors: J
authors: J
authors: Lehmann
authors: B
authors: B
authors: Klein