title: [Preparation and properties of sustained-release pellets of active components from Ligusticun chuanxiong].
abstract: OBJECTIVE
  To prepare sustained-release pellets of active components from Ligusticun chuanxiong by coating in the fluid-bed.
  
  
  METHODS
  The fast-release pellets were prepared by the extrusion-spheronization process. The coating formulation was optimized with the release of ferulic acid as criteria. The micromeritic properties and drug dissolution behaviors of the prepared pellets were evaluated.
  
  
  RESULTS
  The pellets presented perfect sphericity. The obviously sustained-release effects were shown in 12 h. The coating weight gain was the major factor impacting drug release.
  
  
  CONCLUSIONS
  The coating pellets show the obviously sustained-release effects.
authors: Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. hfuir@163.com
authors: Yanlong
authors: Y
authors: Hong
authors: Xiao
authors: X
authors: Ling
authors: Yi
authors: Y
authors: Feng
authors: Desheng
authors: D
authors: Xu
authors: Lihua
authors: L
authors: Chen