title: Predictive utility of the Framingham general cardiovascular disease risk profile for cognitive function: evidence from the Whitehall II study.
abstract: Aims Vascular risk factors are associated with cognitive impairment and dementia, although most of the research in this domain focuses on cerebrovascular factors. We examined the relationship between the recently developed Framingham general cardiovascular risk profile and cognitive function and 10-year decline in late midlife. Methods and results Study sample comprised of 3486 men and 1341 women, mean age 55 years [standard deviation (SD)=6], from the Whitehall II study, a longitudinal British cohort study. The Framingham General Cardiovascular Risk profile, assessed between 1997 and 1999, included age, sex, HDL cholesterol, total cholesterol, systolic blood pressure, smoking status, and diabetes status. Measures of cognitive function consisted of tests of reasoning (Alice Heim 4-I), memory, phonemic and semantic fluency, and vocabulary (Mill-Hill), assessed three times (1997-1999, 2002-2004, 2007-2009) over 10 years. In cross-sectional age-adjusted models, 10% point increments in cardiovascular risk were associated with poor performance in all cognitive domains in both men and women (all P-values <0.001). In models adjusted for age, ethnicity, marital status, and education, 10% higher cardiovascular risk was associated with greater overall 10-year cognitive decline in men, reasoning in particular (-0.47; 95% CI: -0.81, -0.11). Conclusion In middle-aged individuals free of cardiovascular disease, an adverse cardiovascular risk profile is associated with poor cognitive function, and decline in at least one cognitive domain in men.
authors: INSERM U1018, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, 16 Avenue Paul Vaillant Couturier,Villejuif Cedex, France. sara.kaffashian@inserm.fr
authors: Sara
authors: S
authors: Kaffashian
authors: Aline
authors: A
authors: Dugravot
authors: Hermann
authors: H
authors: Nabi
authors: G David
authors: GD
authors: Batty
authors: Eric
authors: E
authors: Brunner
authors: Mika
authors: M
authors: Kivimäki
authors: Archana
authors: A
authors: Singh-Manoux
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