title: Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams.
abstract: We describe for the first time the emergence of an mecA-negative Staphylococcus lugdunensis strain with a modified PBP1A/1B that expresses resistance to all β-lactams. A duplication of the tetrapeptide S(569)AYG, which is part of the transpeptidase domain of PBP1A/1B and closely located to the K(583)TG catalytic motif, was associated with this unusual phenotype.
authors: Department of Microbiology, University Hospital of Larissa, Larissa, Greece.
authors: S D
authors: SD
authors: Kotsakis
authors: L S
authors: LS
authors: Tzouvelekis
authors: L
authors: L
authors: Zerva
authors: A
authors: A
authors: Liakopoulos
authors: E
authors: E
authors: Petinaki
references: J Comput Chem. 2005 Dec;26(16):1701-18
references: 16211538
references: Chemotherapy. 2002 Sep;48(4):174-81
references: 12218264
references: Protein Sci. 2006 Nov;15(11):2507-24
references: 17075131
references: Diagn Microbiol Infect Dis. 2010 Dec;68(4):445-8
references: 21094427
references: Methods Mol Biol. 2008;426:145-59
references: 18542861
references: Diagn Microbiol Infect Dis. 2002 Apr;42(4):279-82
references: 12007447
references: Clin Microbiol Rev. 2008 Jan;21(1):111-33
references: 18202439
references: Microb Drug Resist. 2001 Fall;7(3):297-300
references: 11759092
references: Antimicrob Agents Chemother. 1994 May;38(5):1023-6
references: 8067732
references: Antimicrob Agents Chemother. 2010 Nov;54(11):4864-71
references: 20696873
references: J Biol Chem. 2004 Sep 24;279(39):40802-6
references: 15226303
references: J Mol Biol. 2008 Oct 31;383(1):167-77
references: 18760285
references: Biophys J. 2005 Apr;88(4):2472-93
references: 15665128
references: Antimicrob Agents Chemother. 1995 Jan;39(1):103-6
references: 7695289