title: Serum glutamine synthetase has no value as a diagnostic biomarker for Alzheimer's disease.
abstract: In order to test whether serum glutamine synthetase (GS) is of potential diagnostic value for Alzheimer's disease (AD), we set up a study to compare serum GS concentrations between AD patients and control subjects. The study population (n = 165) consisted of AD patients (n = 94) and age-matched (n = 41) and age-unmatched (n = 30) control subjects. Serum GS analysis was performed by means of ELISA. No significant differences in serum GS levels were found between the AD group and age-matched controls. Age correlated positively with serum GS concentrations in AD patients and control subjects. This study suggests that serum GS levels have no diagnostic value for AD.
authors: Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Wilrijk, Belgium.
authors: Yannick
authors: Y
authors: Vermeiren
authors: Nathalie
authors: N
authors: Le Bastard
authors: Christopher M
authors: CM
authors: Clark
authors: Sebastiaan
authors: S
authors: Engelborghs
authors: Peter P
authors: PP
authors: De Deyn
references: Biochim Biophys Acta. 2008 Oct;1782(10):549-58
references: 18760351
references: Neurology. 1999 Jan 1;52(1):78-84
references: 9921852
references: J Struct Biol. 2000 Jun;130(2-3):184-208
references: 10940225
references: Neurology. 1993 Feb;43(2):250-60
references: 8094895
references: J Neurochem. 1997 Jun;68(6):2451-7
references: 9166739
references: Neurochem Res. 1995 Jul;20(7):859-62
references: 7477679
references: J Neurosci Res. 2001 Dec 1;66(5):972-80
references: 11746426
references: Brain Res. 2004 Aug 20;1018(1):86-96
references: 15262209
references: J Neurochem. 1996 May;66(5):2050-6
references: 8780035
references: J Neurochem. 1995 Oct;65(4):1899-902
references: 7561891
references: Mech Ageing Dev. 1996 Feb 24;86(2):105-14
references: 8852931
references: J Psychiatr Res. 1975 Nov;12(3):189-98
references: 1202204
references: J Neurochem. 2006 Apr;97(2):515-26
references: 16539660
references: Arch Neurol. 1999 Oct;56(10):1241-6
references: 10520940
references: Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11949-53
references: 1361232
references: Gerontology. 1985;31(2):95-100
references: 2860050
references: Exp Neurol. 1997 Jan;143(1):82-102
references: 9000448
references: CNS Neurosci Ther. 2009 Winter;15(4):358-74
references: 19840034
references: Clin Chem. 2002 Feb;48(2):375-8
references: 11805026
references: Neurochem Int. 2002 Aug-Sep;41(2-3):123-42
references: 12020613
references: Neurochem Int. 2009 Dec;55(8):820-5
references: 19695299
references: Clin Neurol Neurosurg. 2005 Apr;107(3):165-73
references: 15823670
references: Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10540-3
references: 1683703
references: Free Radic Res. 1997 Sep;27(3):267-81
references: 9350431
references: J Alzheimers Dis. 2010;21(1):291-301
references: 20421698
references: J Neurol Sci. 2011 Jun 15;305(1-2):92-6
references: 21440911
references: Neurochem Res. 2005 Nov;30(11):1443-51
references: 16341942
references: Brain. 2007 Sep;130(Pt 9):2320-6
references: 17586559
references: Neurology. 1984 Jul;34(7):939-44
references: 6610841
references: Metab Brain Dis. 1987 Dec;2(4):283-90
references: 2905419
references: Metab Brain Dis. 1994 Mar;9(1):97-103
references: 7914669