title: Health outcomes of children born to mothers with chronic kidney disease: a pilot study.
abstract: This study aimed to study the health of children born to mothers with chronic kidney disease. Twenty-four children born to mothers with chronic kidney disease were compared with 39 matched control children born to healthy mothers without kidney disease. The well-being of each child was individually assessed in terms of physical health, neurodevelopment and psychological health. Families participating with renal disease were more likely to be from lower socio-economic backgrounds. Significantly fewer vaginal deliveries were reported for mothers with renal disease and their infants were more likely to experience neonatal morbidity. Study and control children were comparable for growth parameters and neurodevelopment as assessed by the Griffiths scales. There was no evidence of more stress amongst mothers with renal disease or of impaired bonding between mother and child when compared to controls. However, there was evidence of greater externalizing behavioral problems in the group of children born to mothers with renal disease. Engaging families in such studies is challenging. Nonetheless, families who participated appreciated being asked. The children were apparently healthy but there was evidence in this small study of significant antenatal and perinatal morbidity compared to controls. Future larger multi-center studies are required to confirm these early findings.
authors: General and Adolescent Paediatrics Unit, Institute of Child Health, University College London;
authors: Indrani
authors: I
authors: Banerjee
authors: Stephen
authors: S
authors: Powis
authors: Mark
authors: M
authors: Shevlin
authors: Jacqueline
authors: J
authors: Barnes
authors: Audrey
authors: A
authors: Soo
authors: Alastair G
authors: AG
authors: Sutcliffe
references: N Engl J Med. 1963 Aug 15;269:341-3
references: 13936776
references: Transplant Proc. 1999 Feb-Mar;31(1-2):241-2
references: 10083092
references: N Engl J Med. 2006 Mar 23;354(12):1281-93
references: 16554530
references: Curr Opin Obstet Gynecol. 2001 Apr;13(2):109-14
references: 11315862
references: J Paediatr Child Health. 2000 Jun;36(3):230-5
references: 10849222
references: Lancet. 1975 Oct 25;2(7939):801-2
references: 78159
references: N Engl J Med. 1996 Jul 25;335(4):226-32
references: 8657238
references: Teratology. 2002 Jan;65(1):5-9
references: 11835226
references: Am J Kidney Dis. 1999 Feb;33(2):235-52
references: 10023634
references: Nephrol Dial Transplant. 1999 Jun;14(6):1511-6
references: 10383016
references: Psychol Med. 1979 Feb;9(1):139-45
references: 424481