title: Thermal solvent-free synthesis of chromonyl chalcones, pyrazolines and their in vitro antibacterial, antifungal activities.
abstract: A facile and ecofriendly synthesis of new chromonyl chalcones 3a-b from 3-formylchromone 1 and active methyl compounds 2a-b is reported under thermal solvent-free heating condition in good yields. The chromonyl chalcones 3a-b were used as intermediates under green condition for the synthesis of new bioactive pyrazoline derivatives 4a-f. The compounds were tested for antimicrobial activity by disk diffusion assay with slight modifications against Gram-positive, Gram-negative strains of bacteria as well as fungal strains. The investigation of antimicrobial screening revealed that compounds 3a-b and 4a-f showed antibacterial and antifungal activities.
authors: Department of Chemistry, Aligarh Muslim University, Aligarh, India. siddiqui_zeba@yahoo.co.in
authors: Zeba N
authors: ZN
authors: Siddiqui
authors: Shagufta
authors: S
authors: Praveen
authors: T N Mohammed
authors: TN
authors: Musthafa
authors: Anis
authors: A
authors: Ahmad
authors: Asad U
authors: AU
authors: Khan