title: Regulation of adult neurogenesis by behavior and age in the accessory olfactory bulb.
abstract: The vomeronasal system (VNS) participates in the detection and processing of pheromonal information related to social and sexual behaviors. Within the VNS, two different populations of sensory neurons, with a distinct pattern of distribution, line the epithelium of the vomeronasal organ (VNO) and give rise to segregated sensory projections to the accessory olfactory bulb (AOB). Apical sensory neurons in the VNO project to the anterior AOB (aAOB), while basal neurons project to the posterior AOB (pAOB). In the AOB, the largest population of neurons are inhibitory, the granule and periglomerular cells (GCs and PGs) and remarkably, these neurons are continuously born and functionally integrated in the adult brain, underscoring their role on olfactory function. Here we show that behaviors mediated by the VNS differentially regulate adult neurogenesis across the anterior-posterior axis of the AOB. We used immunohistochemical labeling of newly born cells under different behavioral conditions in mice. Using a resident-intruder aggression paradigm, we found that subordinate mice exhibited increased neurogenesis in the aAOB. In addition, in sexually naive adult females exposed to soiled bedding odorized by adult males, the number of newly born cells was significantly increased in the pAOB; however, neurogenesis was not affected in females exposed to female odors. In addition, we found that at two months of age adult neurogenesis was sexually dimorphic, with male mice exhibiting higher levels of newly born cells than females. Interestingly, adult neurogenesis was greatly reduced with age and this decrease correlated with a decrease in progenitor cells proliferation but not with an increase in cell death in the AOB. These results indicate that the physiological regulation of adult neurogenesis in the AOB by behaviors is both sex and age dependent and suggests an important role of newly born neurons in sex dependent behaviors mediated by the VNS.
authors: Department of Biology and Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, MD 20742, USA.
authors: Alexia
authors: A
authors: Nunez-Parra
authors: Victoria
authors: V
authors: Pugh
authors: Ricardo C
authors: RC
authors: Araneda
references: J Neurosci. 1984 Sep;4(9):2222-9
references: 6541245
references: Horm Behav. 2008 Apr;53(4):509-17
references: 18258236
references: J Comp Neurol. 2002 Dec 23;454(4):361-72
references: 12455003
references: Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6376-81
references: 11972034
references: Cell Mol Life Sci. 2006 Jul;63(13):1476-84
references: 16732428
references: Development. 1992 Sep;116(1):201-11
references: 1483388
references: Nature. 1970 Jun 6;226(5249):967-8
references: 5463060
references: Curr Biol. 2003 Jul 15;13(14):1214-9
references: 12867032
references: Nat Neurosci. 2007 Aug;10(8):1003-11
references: 17603480
references: Curr Protoc Neurosci. 2006 Feb;Chapter 8:Unit8.4
references: 18428648
references: An Acad Bras Cienc. 2003 Dec;75(4):469-86
references: 14605681
references: Nat Rev Neurosci. 2006 Mar;7(3):179-93
references: 16495940
references: Nat Neurosci. 2005 Dec;8(12):1660-2
references: 16261133
references: J Neurosci. 2001 Apr 1;21(7):2474-80
references: 11264321
references: Brain Res. 2000 Sep 8;876(1-2):211-4
references: 10973612
references: Brain Res. 1996 May 6;719(1-2):117-28
references: 8782871
references: Nat Neurosci. 2003 May;6(5):507-18
references: 12704391
references: Chem Senses. 2005 Jan;30 Suppl 1:i146-7
references: 15738083
references: Cell. 2010 May 14;141(4):692-703
references: 20478258
references: Nat Rev Neurosci. 2003 Jul;4(7):551-62
references: 12838330
references: J Neurosci. 2009 Apr 8;29(14):4408-19
references: 19357268
references: Physiol Behav. 2007 Apr 23;90(5):797-802
references: 17306314
references: Science. 1994 May 20;264(5162):1145-8
references: 8178174
references: Genes Cells. 2006 Oct;11(10):1145-59
references: 16999735
references: Behav Brain Res. 2009 Mar 17;198(2):306-12
references: 19046995
references: J Neurosci. 2006 Oct 11;26(41):10508-13
references: 17035535
references: J Neurosci. 2003 Nov 12;23(32):10411-8
references: 14614100
references: Trends Neurosci. 2008 Aug;31(8):392-400
references: 18603310
references: Physiol Rev. 2009 Jul;89(3):921-56
references: 19584317
references: J Comp Neurol. 1965 Jun;124(3):319-35
references: 5861717
references: Eur J Neurosci. 2009 Feb;29(4):679-92
references: 19200078
references: Nature. 1959 Jul 11;184:105
references: 13805128
references: Science. 2003 Jan 3;299(5603):117-20
references: 12511652
references: J Neurosci. 2004 Oct 20;24(42):9451-7
references: 15496681
references: PLoS One. 2009 Jul 23;4(7):e6359
references: 19626121
references: J Endocrinol. 1975 Mar;64(3):38P
references: 1133523
references: Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2074-7
references: 8446631
references: Behav Brain Res. 1999 Nov 1;105(1):69-80
references: 10553691
references: J Comp Neurol. 2005 Sep 5;489(4):491-500
references: 16025460
references: Cell Tissue Res. 2001 Dec;306(3):385-9
references: 11735038
references: J Neurosci. 2008 Nov 5;28(45):11511-6
references: 18987187
references: Horm Behav. 2001 Feb;39(1):11-21
references: 11161879
references: Physiol Behav. 1982 Jan;28(1):31-7
references: 7079320
references: Behav Brain Res. 2006 Sep 25;172(2):344-50
references: 16839619
references: J Neurosci. 2005 Jul 20;25(29):6816-25
references: 16033891
references: J Neurosci. 2004 Sep 22;24(38):8354-65
references: 15385618
references: Neuroreport. 2006 Nov 6;17(16):1663-7
references: 17047450
references: Trends Neurosci. 2005 May;28(5):248-54
references: 15866199
references: Cell. 1999 Apr 16;97(2):199-208
references: 10219241
references: Brain Res. 2006 Aug 2;1102(1):52-62
references: 16806123
references: Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):191-9
references: 17023106
references: PLoS One. 2010 Jun 29;5(6):e11359
references: 20613876
references: Eur J Neurosci. 2009 Feb;29(3):624-34
references: 19187265
references: Annu Rev Neurosci. 2005;28:223-50
references: 16022595
references: J Neurosci. 2006 Jul 12;26(28):7375-9
references: 16837584
references: Physiol Behav. 1986;37(4):655-7
references: 3749330
references: Neuropsychopharmacology. 2009 Feb;34(3):786-95
references: 18946468
references: J Neurobiol. 2002 May;51(2):115-28
references: 11932953
references: Nature. 1965 Aug 28;207(5000):953-6
references: 5886931
references: Neurosci Lett. 2007 Feb 8;413(1):11-5
references: 17125926
references: Nat Neurosci. 2009 Dec;12(12):1524-33
references: 19881504
references: Horm Behav. 2002 May;41(3):343-50
references: 11971669
references: Acta Physiol Scand Suppl. 1997;640:69-72
references: 9401610
references: C R Biol. 2007 Jun-Jul;330(6-7):510-20
references: 17631446
references: Nature. 2007 Dec 6;450(7171):899-902
references: 18064011
references: Neuroscience. 1999;90(4):1463-70
references: 10338312
references: Eur J Neurosci. 2007 Jul;26(2):463-75
references: 17623023
references: J Neurosci. 2002 Apr 1;22(7):2679-89
references: 11923433
references: Neuroscience. 2008 Jan 2;151(1):120-8
references: 18093744
references: J Anat. 1996 Feb;188 ( Pt 1):1-15
references: 8655396
references: Behav Brain Res. 2009 Jun 25;200(2):315-22
references: 19374018
references: Ageing Res Rev. 2004 Apr;3(2):215-32
references: 15177056
references: Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10409-14
references: 9294224
references: J Neurosci. 2009 Sep 30;29(39):12302-14
references: 19793989
references: Cell. 1997 Aug 22;90(4):763-73
references: 9288755
references: Cell. 2008 Feb 22;132(4):645-60
references: 18295581
references: Horm Behav. 1996 Dec;30(4):455-73
references: 9047271
references: Science. 2007 Jul 20;317(5836):381-4
references: 17615304
references: J Comp Neurol. 1995 Aug 28;359(3):382-90
references: 7499536
references: Neuron. 2006 Jun 1;50(5):697-709
references: 16731509
references: Annu Rev Physiol. 2009;71:141-60
references: 18817511
references: Science. 2002 Feb 22;295(5559):1493-500
references: 11823606
references: Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17980-5
references: 19815505
references: J Endocrinol. 1959 Jan;18(1):102-7
references: 13620841
references: J Neurosci. 1999 Oct 15;19(20):RC32
references: 10516334
references: Neuroreport. 1997 May 6;8(7):1679-83
references: 9189914
references: Curr Opin Neurobiol. 1995 Aug;5(4):482-8
references: 7488850
references: Physiol Behav. 2006 Sep 30;89(2):123-7
references: 16837015
references: Trends Neurosci. 2003 Sep;26(9):501-6
references: 12948662
references: Eur J Neurosci. 1999 Jul;11(7):2254-60
references: 10383614
references: Neuroscience. 1999;91(4):1549-56
references: 10391458
references: Brain Res. 1995 Apr 17;677(1):157-61
references: 7606461
references: J Neurosci. 2002 Jul 15;22(14):6106-13
references: 12122071
references: Behav Brain Res. 2009 Jun 25;200(2):268-76
references: 19374011
references: Nat Neurosci. 2008 Jan;11(1):80-7
references: 18084286