title: C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4.
abstract: CKLF1, a human cytokine that is a functional ligand for CCR4, is upregulated in various inflammation and autoimmune diseases. CKLF1 contains at least two secreted forms, the C-terminal peptides C19 and C27. Chemically synthesized C19 and C27 can interact with CCR4 and attenuate allergic inflammation. In this study, we found C19 and C27 could inhibit SDF-1-induced CXCR4-mediated chemotaxis and promote CXCR4 internalization. The inhibitory effect was due to desensitization of CXCR4, which was mediated by CCR4. Further experiments confirmed that CXCR4 desensitization required activation of PI3K/PKC pathway. Altogether our data elucidate the mechanism of C19- and C27-induced CXCR4 desensitization.
authors: Center for Human Disease Genomics, Peking University, 38 Xueyuan Road, Beijing 100191, PR China.
authors: Yan
authors: Y
authors: Zhang
authors: Linjie
authors: L
authors: Tian
authors: Yi
authors: Y
authors: Zheng
authors: Hui
authors: H
authors: Qi
authors: Changyuan
authors: C
authors: Guo
authors: Qianying
authors: Q
authors: Sun
authors: Enquan
authors: E
authors: Xu
authors: Yingmei
authors: Y
authors: Zhang
authors: Dalong
authors: D
authors: Ma
authors: Ying
authors: Y
authors: Wang