title: Inhibition of the NF-kappaB pathway in human intestinal epithelial cells by commensal Streptococcus salivarius.
abstract: Streptococcus salivarius exhibited an anti-inflammatory effect on intestinal epithelial cells (IECs) and monocytes. Strains were screened using a reporter clone, HT-29/kB-luc-E, induced by tumor necrosis factor alpha (TNF-α). Supernatant from each strain downregulated NF-κB activation. The two most efficient strains produced an active metabolite (<3 kDa) which was able to downregulate the secretion of the proinflammatory chemokine interleukin-8 (IL-8).
authors: Commensal and Food Bacteria Group, INRA, UMR1319 Micalis, Domaine de Vilvert, F-78352 Jouy-en-Josas, France.
authors: Ghalia
authors: G
authors: Kaci
authors: Omar
authors: O
authors: Lakhdari
authors: Joël
authors: J
authors: Doré
authors: S Dusko
authors: SD
authors: Ehrlich
authors: Pierre
authors: P
authors: Renault
authors: Hervé M
authors: HM
authors: Blottière
authors: Christine
authors: C
authors: Delorme
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