title: Complement regulator factor H in multiple sclerosis.
abstract: A recent proteomic study published in this journal demonstrated lower cerebrospinal fluid (CSF) expression of factor H (fH), an important complement regulator, along with two other complement proteins, in active multiple sclerosis (MS) patients. We have previously demonstrated raised serum fH levels in MS and here, an extended analysis, quantifying fH in CSF, demonstrates no change in fH levels in active disease, but significantly raised levels in progressive disease. These findings support our previous work showing raised serum fH in patients with progressive MS, and our results predict that CSF fH levels will be raised rather than reduced in active disease.
authors: Department of Neurology, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
authors: Gillian
authors: G
authors: Ingram
authors: Svetlana
authors: S
authors: Hakobyan
authors: Samantha
authors: S
authors: Loveless
authors: Neil
authors: N
authors: Robertson
authors: B Paul
authors: BP
authors: Morgan