title: Stereoselective synthesis of deuterated β-cyclohexenylserine, a biosynthetic intermediate of the salinosporamides.
abstract: A straightforward, highly stereoselective protocol toward the synthesis of deuterium-labeled (2R,3S,4S)-β-cyclohexenylserine has been developed. Key steps are a Nozaki-Hiyama-Kishi reaction generating the stereogenic centers and a ring-closing metathesis for the construction of the cyclohexenyl ring system. The labeled amino acid was further activated as an SNAc-ester for feeding experiments.
authors: Universität des Saarlandes, Institut für Organische Chemie, Im Stadtwald, Geb. C4.2, D-66123 Saarbrücken, Germany.
authors: Jan
authors: J
authors: Deska
authors: Saskia
authors: S
authors: Hähn
authors: Uli
authors: U
authors: Kazmaier