title: [Intracellular accumulation and antitumor activity of various nanosomal formulations of paclitaxel].
abstract: Paclitaxel-loaded poly(lactic-glycolic) copolymer nanoparticles have been prepared using a precipitation technique. The cytotoxic activity of nanosomal paclitaxel was studied on the model of highly resistant cell line Jurkat WT (human T-cell leukemia) using various biochemical assays. It is found that the inhibitory concentration (IC50) for the experimental formulation of paclitaxel falls within 10(-4)-10(-6) M. Accumulation of nanoparticles in the highly resistant Jurkat/WT cells was revealed by fluorescence microscopy.
authors: V
authors: V
authors: Boiat
authors: V Iu
authors: VIu
authors: Balaban'ian
authors: R N
authors: RN
authors: Aliautdin