title: Novel flavonoids with antiproliferative activities against breast cancer cells.
abstract: A series of flavone analogues were synthesized and evaluated for their antiproliferation activity against breast cancer cells. The IC(50) of compound 10 and 24 were determined to be at 5 μM. These compounds were used as baits to screen breast cancer cDNA expression phage display proteome library. DNA sequencing of the binding phages suggests that eEF1A1 is a target protein for 10 and 24. Further optimization of these compounds led to the discovery of 39 with higher cytotoxic potency (IC(50) = 1 μM) and binding to eEF1A2. Biological and biochemical data suggest that eEF1A2 might be a therapeutic target and that 39 is an excellent lead compound for further development.
authors: Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, California 95817, United States.
authors: Nianhuan
authors: N
authors: Yao
authors: Chao-Yu
authors: CY
authors: Chen
authors: Chun-Yi
authors: CY
authors: Wu
authors: Kiyomi
authors: K
authors: Motonishi
authors: Hsing-Jien
authors: HJ
authors: Kung
authors: Kit S
authors: KS
authors: Lam
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