title: Food allergy and atopic dermatitis: how are they connected?
abstract: Food allergy predominantly affects children rather than adults with atopic dermatitis (AD). Early food sensitization has been found to be significantly associated with AD. Three different patterns of clinical reactions to food allergens in AD patients have been identified: 1) immediate-type symptoms, 2) isolated eczematous late-type reactions, and 3) combined reactions. Whereas in children, allergens from cow's milk, hen's egg, soy, wheat, fish, peanut, or tree nuts are primarily responsible for allergic reactions, birch pollen-related food allergens seem to play a major role in adolescent and adults with AD in Central and Northern Europe. Defects in the epidermal barrier function seem to facilitate the development of sensitization to allergens following epicutaneous exposure. The relevance of defects in the gut barrier as well as genetic characteristics associated with an increased risk of food allergy remain to be further investigated. Many studies focus on sufficient strategies of prevention, which actually include breastfeeding or feeding with hydrolyzed formula during the first 4 months of life.
authors: Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Ricklinger Str. 5, 30449, Hannover, Germany. heratizadeh.annice@mh-hannover.de
authors: Annice
authors: A
authors: Heratizadeh
authors: Katja
authors: K
authors: Wichmann
authors: Thomas
authors: T
authors: Werfel
references: Pediatr Allergy Immunol. 2008 Feb;19(1):1-4
references: 18199086
references: Acta Paediatr. 2009 Sep;98(9):1461-7
references: 19489765
references: Curr Allergy Asthma Rep. 2008 May;8(3):188-94
references: 18589836
references: Br J Dermatol. 1996 Dec;135(6):935-41
references: 8977715
references: J Allergy Clin Immunol. 2004 Jan;113(1):148-54
references: 14713921
references: Nat Genet. 2009 May;41(5):602-8
references: 19349982
references: Pediatr Allergy Immunol. 2010 Mar;21(2 Pt 2):e355-67
references: 19573143
references: J Allergy Clin Immunol. 2007 Jan;119(1):184-91
references: 17208600
references: Allergy. 2010 Feb;65(2):213-9
references: 19712120
references: Allergy. 2009 Jul;64(7):1023-9
references: 19220211
references: J Allergy Clin Immunol. 2007 Jul;120(1):150-5
references: 17512043
references: J Chromatogr B Biomed Sci Appl. 2001 May 25;756(1-2):19-32
references: 11419712
references: J Allergy Clin Immunol. 2010 Oct;126(4):791-7
references: 20832848
references: J Allergy Clin Immunol. 1999 Aug;104(2 Pt 1):466-72
references: 10452773
references: Lancet. 2002 Aug 31;360(9334):701-10
references: 12241890
references: Lancet. 2001 Apr 7;357(9262):1076-9
references: 11297958
references: Curr Opin Clin Nutr Metab Care. 2008 May;11(3):320-8
references: 18403931
references: J Allergy Clin Immunol. 1997 Jan;99(1 Pt 1):124-33
references: 9003220
references: Pediatr Allergy Immunol. 2010 Mar;21(2 Pt 2):e386-93
references: 19840300
references: J Clin Invest. 1995 Feb;95(2):913-8
references: 7532192
references: Pediatrics. 2008 Apr;121(4):e850-6
references: 18332075
references: J Allergy Clin Immunol. 2008 Jun;121(6):1442-7
references: 18539195
references: J Allergy Clin Immunol. 2006 Aug;118(2):481-8
references: 16890775
references: J Allergy Clin Immunol. 2002 Nov;110(5):797-804
references: 12417891
references: Pediatr Allergy Immunol. 2010 Feb;21(1 Pt 1):60-6
references: 20088862
references: Pediatr Allergy Immunol. 2005 Mar;16(2):113-20
references: 15787867
references: J Allergy Clin Immunol. 2007 Aug;120(2):343-50
references: 17604093
references: J Allergy Clin Immunol. 2008 Jun;121(6):1337-43
references: 18329087
references: BMJ. 2009 Jul 09;339:b2433
references: 19589816
references: J Nutr. 2008 Jun;138(6):1091-5
references: 18492839
references: Allergy. 2007 Jul;62(7):723-8
references: 17573718
references: Clin Exp Allergy. 2004 May;34(5):817-24
references: 15144477
references: Curr Allergy Asthma Rep. 2010 May;10(3):215-21
references: 20424996
references: Clin Exp Allergy. 2010 Aug;40(8):1247-55
references: 20545710
references: Semin Cutan Med Surg. 2010 Jun;29(2):72-8
references: 20579595
references: J Allergy Clin Immunol. 2009 Feb;123(2):452-8
references: 18996574
references: Eur J Immunol. 2004 Aug;34(8):2100-9
references: 15259007
references: Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):394-9
references: 20629265
references: J Allergy Clin Immunol. 2001 Aug;108(2):301-7
references: 11496252
references: J Allergy Clin Immunol. 2001 Apr;107(4):693-702
references: 11295660
references: J Allergy Clin Immunol. 2002 Jul;110(1):167-73
references: 12110837
references: J Allergy Clin Immunol. 1998 Feb;101(2 Pt 1):207-9
references: 9500753
references: J Allergy Clin Immunol. 2006 Jul;118(1):242-9
references: 16815162
references: Clin Exp Allergy. 2008 Jan;38(1):161-8
references: 18028467
references: J Allergy Clin Immunol. 2000 Mar;105(3):577-81
references: 10719310
references: J Allergy Clin Immunol. 2001 May;107(5):891-6
references: 11344358
references: J Allergy Clin Immunol. 2008 Apr;121(4):940-46.e3
references: 18313126
references: J Pediatr. 2007 Oct;151(4):352-8
references: 17889067
references: N Engl J Med. 2003 Mar 13;348(11):977-85
references: 12637607
references: N Engl J Med. 2008 Sep 18;359(12):1252-60
references: 18799559
references: J Allergy Clin Immunol. 2010 Jan;125(1):16-29.e1-11; quiz 30-1
references: 20109730
references: Arch Dis Child. 2006 Oct;91(10):814-9
references: 16873437
references: J Dtsch Dermatol Ges. 2010 Sep;8(9):718-24
references: 19878402
references: Pediatr Allergy Immunol. 2009 Dec;20(8):726-34
references: 19744222
references: J Allergy Clin Immunol. 2000 Aug;106(2):373-8
references: 10932083
references: J Pediatr Gastroenterol Nutr. 2010 Apr;50(4):422-30
references: 20216095
references: Clin Exp Allergy. 2008 Feb;38(2):233-45
references: 18081883
references: J Pediatr. 2011 Apr;158(4):578-583.e1
references: 21030035
references: Acta Derm Venereol. 2006;86(2):119-22
references: 16648913
references: Allergy. 2009 Jun;64(6):840-8
references: 19392990
references: Clin Exp Allergy. 2003 Aug;33(8):1067-75
references: 12911780
references: Allergy. 2005 Aug;60(8):1034-9
references: 15969684