title: Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model.
abstract: Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.
authors: Clinic of Plastic Surgery, Breast Surgery and Burns Unit, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
authors: A H
authors: AH
authors: Chakera
authors: B S
authors: BS
authors: Nielsen
authors: J
authors: J
authors: Madsen
authors: J
authors: J
authors: Romer
authors: P E G
authors: PE
authors: Kristjansen
authors: I
authors: I
authors: Buch
authors: T
authors: T
authors: Binderup
authors: C
authors: C
authors: Ingvar
authors: A
authors: A
authors: Nalla
authors: A
authors: A
authors: Kjaer
authors: B
authors: B
authors: Hesse
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