title: Feasibility of a lifestyle intervention for ovarian cancer patients receiving adjuvant chemotherapy.
abstract: OBJECTIVE
  This study aimed to assess the feasibility of a lifestyle intervention for promoting physical activity (PA) and diet quality during adjuvant chemotherapy for ovarian cancer.
  
  
  METHODS
  Patients were enrolled post-operatively and received PA and nutrition counseling, at every chemotherapy visit for six cycles. Quality of life (QoL) was measured with the Functional Assessment of Cancer Therapy (FACT-G), PA with the Leisure Score Index (LSI), dietary intake with 3-day food records, and symptom severity/distress by the Memorial Symptom Assessment Scale (MSAS). Pedometer step count was collected during chemotherapy cycles.
  
  
  RESULTS
  Recruitment was 73% with 27 patients enrolled. Mean [95% confidence interval] change in minutes of PA from cycle #3 to following cycle #6 was 61 min [-3, 120] p=0.063, and from baseline to after cycle #6 was 73 min [-10, 15]; p=0.082. Mean change in total fruit and vegetable consumption between baseline and during chemotherapy was 0.56 [-0.09, 0.64]; p=0.090. FACT-G increased from 75.4 at baseline to 77.6 during chemotherapy and 83.9 following chemotherapy (p=0.001 for change from baseline to post-chemotherapy). Mean total MSAS score was 20.6 at baseline, 26.6 at cycle #3 and decreased to 17.0 following chemotherapy (p=0.01 comparison of cycle #3 and following chemotherapy). Increased moderate to strenuous PA was correlated with higher physical well-being during chemotherapy (r=0.48, p=0.037).
  
  
  CONCLUSIONS
  Lifestyle counseling during adjuvant chemotherapy for ovarian cancer is feasible and may improve PA and diet quality. Randomized controlled trials examining the effects of lifestyle counseling on quality of life and treatment outcomes in ovarian cancer patients are warranted.
authors: Summa Health System/Akron City Hospital, Akron, OH 44309, USA. vongruev@summahealth.org
authors: Vivian E
authors: VE
authors: von Gruenigen
authors: Heidi E
authors: HE
authors: Frasure
authors: Mary Beth
authors: MB
authors: Kavanagh
authors: Edith
authors: E
authors: Lerner
authors: Steven E
authors: SE
authors: Waggoner
authors: Kerry S
authors: KS
authors: Courneya