title: Opposing amygdala and ventral striatum connectivity during emotion identification.
abstract: Lesion and electrophysiological studies in animals provide evidence of opposing functions for subcortical nuclei such as the amygdala and ventral striatum, but the implications of these findings for emotion identification in humans remain poorly described. Here we report a high-resolution fMRI study in a sample of 39 healthy subjects who performed a well-characterized emotion identification task. As expected, the amygdala responded to THREAT (angry or fearful) faces more than NON-THREAT (sad or happy) faces. A functional connectivity analysis of the time series from an anatomically defined amygdala seed revealed a strong anticorrelation between the amygdala and the ventral striatum/ventral pallidum, consistent with an opposing role for these regions in during emotion identification. A second functional connectivity analysis (psychophysiological interaction) investigating relative connectivity on THREAT vs. NON-THREAT trials demonstrated that the amygdala had increased connectivity with the orbitofrontal cortex during THREAT trials, whereas the ventral striatum demonstrated increased connectivity with the posterior hippocampus on NON-THREAT trials. These results indicate that activity in the amygdala and ventral striatum may be inversely related, and that both regions may provide opposing affective bias signals during emotion identification.
authors: Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. sattertt@upenn.edu
authors: Theodore D
authors: TD
authors: Satterthwaite
authors: Daniel H
authors: DH
authors: Wolf
authors: Amy E
authors: AE
authors: Pinkham
authors: Kosha
authors: K
authors: Ruparel
authors: Mark A
authors: MA
authors: Elliott
authors: Jeffrey N
authors: JN
authors: Valdez
authors: Eve
authors: E
authors: Overton
authors: Janina
authors: J
authors: Seubert
authors: Raquel E
authors: RE
authors: Gur
authors: Ruben C
authors: RC
authors: Gur
authors: James
authors: J
authors: Loughead
references: Neuroimage. 2006 Jun;31(2):906-19
references: 16488159
references: Neuron. 2009 Mar 12;61(5):786-800
references: 19285474
references: J Neurosci Methods. 2002 Apr 15;115(2):137-43
references: 11992665
references: Am J Psychiatry. 2003 Oct;160(10):1768-74
references: 14514489
references: J Neurophysiol. 2008 Dec;100(6):3328-42
references: 18799601
references: Cogn Neuropsychiatry. 2006 May;11(3):219-32
references: 17354069
references: J Neurophysiol. 2009 Jun;101(6):3270-83
references: 19339462
references: Neuroimage. 2009 Apr 1;45(2):614-26
references: 19110061
references: J Pers Soc Psychol. 1989 Jul;57(1):55-66
references: 2754604
references: Science. 2007 May 11;316(5826):904-6
references: 17431137
references: Neuroimage. 2009 Feb 1;44(3):893-905
references: 18976716
references: Neuron. 2004 May 13;42(3):509-17
references: 15134646
references: J Psychiatr Res. 1992 Jul;26(3):169-82
references: 1432844
references: Nature. 1994 Dec 15;372(6507):669-72
references: 7990957
references: Cell Mol Neurobiol. 2003 Oct;23(4-5):727-38
references: 14514027
references: J Clin Exp Neuropsychol. 2009 Apr;31(3):278-91
references: 18720178
references: J Neurosci. 2008 Mar 12;28(11):2719-25
references: 18337401
references: Neuron. 2005 Oct 20;48(2):175-87
references: 16242399
references: Schizophr Bull. 2009 Jan;35(1):153-62
references: 19011231
references: Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10456-9
references: 10468630
references: PLoS One. 2008 Jan 30;3(1):e1506
references: 18231593
references: Emotion. 2001 Mar;1(1):70-83
references: 12894812
references: Nature. 2008 Oct 16;455(7215):894-902
references: 18923511
references: Trends Cogn Sci. 2000 Jun;4(6):223-233
references: 10827445
references: Am J Physiol. 1960 Dec;199:965-8
references: 13730698
references: Neuroreport. 2000 Jan 17;11(1):43-8
references: 10683827
references: Neuron. 2008 Apr 24;58(2):273-83
references: 18439411
references: Neuroscience. 2003;118(4):1099-120
references: 12732254
references: J Comp Physiol Psychol. 1954 Jun;47(3):173-8
references: 13163250
references: Curr Psychiatry Rep. 2006 Aug;8(4):322-8
references: 16879797
references: Am J Psychiatry. 2010 Apr;167(4):418-26
references: 20194482
references: Arch Gen Psychiatry. 2002 Nov;59(11):1027-34
references: 12418936
references: Neuroimage. 2004 Apr;21(4):1215-23
references: 15050549
references: Nature. 2001 May 17;411(6835):305-9
references: 11357132
references: Arch Neurol. 2008 Dec;65(12):1604-11
references: 19064747
references: Hum Brain Mapp. 2002 Nov;17(3):143-55
references: 12391568
references: Neuroimage. 1997 Oct;6(3):218-29
references: 9344826
references: J Neurosci. 2003 Sep 3;23(22):8092-7
references: 12954871
references: J Neurophysiol. 2007 Feb;97(2):1671-83
references: 17093126
references: Neuropsychopharmacology. 2010 Jan;35(1):337
references: 20010703
references: Neuroimage. 2006 Feb 1;29(3):977-83
references: 16153860
references: Hum Brain Mapp. 2009 Nov;30(11):3748-58
references: 19530218
references: Neuroimage. 2002 Jul;16(3 Pt 1):651-62
references: 12169250
references: Brain Res. 1985 Mar 11;329(1-2):241-57
references: 3978445
references: J Neurosci Methods. 2010 Mar 30;187(2):254-62
references: 19945485
references: J Neurosci. 1995 Sep;15(9):5879-91
references: 7666173
references: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
references: 15976020
references: J Neurosci. 1997 Jun 1;17(11):4302-11
references: 9151747
references: Am J Psychiatry. 2009 Jun;166(6):702-10
references: 19411368
references: Nature. 2005 Jan 6;433(7021):68-72
references: 15635411
references: J Neurophysiol. 2006 Dec;96(6):3517-31
references: 16899645
references: Neuron. 2001 Nov 8;32(3):537-51
references: 11709163
references: J Comp Neurol. 1984 Dec 20;230(4):465-96
references: 6520247
references: Arch Gen Psychiatry. 2007 Dec;64(12):1356-66
references: 18056543
references: Brain Res. 2008 Feb 15;1194:37-44
references: 18191116
references: Neuroimage. 2001 Dec;14(6):1370-86
references: 11707093
references: J Comp Physiol Psychol. 1954 Dec;47(6):419-27
references: 13233369
references: Brain Res Brain Res Rev. 2003 Jan;41(1):88-123
references: 12505650
references: Nature. 2007 May 3;447(7140):83-6
references: 17476267
references: Neuron. 2005 Apr 21;46(2):309-20
references: 15848808
references: Cereb Cortex. 2005 Dec;15(12):1866-76
references: 15746001
references: Arch Gen Psychiatry. 2009 Dec;66(12):1361-72
references: 19996041
references: Neuroimage. 2011 Mar 1;55(1):371-80
references: 21122818
references: Can J Psychol. 1991 Mar;45(1):1-36
references: 2044020
references: J Neurosci. 2001 Aug 15;21(16):RC159
references: 11459880
references: J Neurosci. 2009 Nov 25;29(47):14864-8
references: 19940182
references: Neuroimage. 2002 Oct;17(2):825-41
references: 12377157
references: Neuroimage. 2007 Sep 1;37(3):1017-31
references: 17632014
references: J Neurosci. 2006 Sep 6;26(36):9264-71
references: 16957082
references: Neuroimage. 2006 May 1;30(4):1441-8
references: 16368249
references: Neurosci Biobehav Rev. 2008;32(4):811-30
references: 18316124
references: Neuroimage. 2009 Feb 1;44(3):1144-51
references: 18996489
references: Cereb Cortex. 2007 Oct;17(10):2400-6
references: 17190969
references: Psychol Bull. 1987 Jan;101(1):91-119
references: 3562705
references: J Pers Soc Psychol. 2001 May;80(5):797-803
references: 11374750
references: Nat Neurosci. 2001 Apr;4(4):437-41
references: 11276236
references: Hum Brain Mapp. 2009 Feb;30(2):532-40
references: 18095279
references: J Neurosci. 2009 Sep 16;29(37):11614-8
references: 19759308
references: Ann N Y Acad Sci. 2003 Dec;1000:337-47
references: 14766647
references: Nat Rev Neurosci. 2007 Sep;8(9):700-11
references: 17704812
references: Neuron. 1996 Nov;17(5):875-87
references: 8938120
references: Magn Reson Med. 2002 Jul;48(1):137-46
references: 12111941
references: Biol Psychiatry. 2009 Nov 1;66(9):847-53
references: 19709644
references: Nature. 1996 Oct 31;383(6603):812-5
references: 8893004
references: Nature. 1998 Jun 4;393(6684):470-4
references: 9624002
references: Ann N Y Acad Sci. 2007 May;1104:54-69
references: 17416922
references: Annu Rev Neurosci. 2000;23:155-84
references: 10845062
references: Neuron. 2008 Jun 12;58(5):662-71
references: 18549779
references: J Neurosci. 2001 Apr 15;21(8):2793-8
references: 11306631
references: Cereb Cortex. 2006 Apr;16(4):561-73
references: 16033924
references: Neuropsychologia. 2007 Jan 7;45(1):174-94
references: 16854439
references: J Cogn Neurosci. 2004 Oct;16(8):1388-411
references: 15509386
references: J Comp Neurol. 1963 Apr;120:259-95
references: 13939939
references: Neuroimage. 2005 May 15;26(1):141-8
references: 15862214
references: Biol Psychiatry. 2002 Jan 1;51(1):59-67
references: 11801231
references: Nat Neurosci. 2004 Nov;7(11):1271-8
references: 15494727
references: Neuroimage. 2011 Jan 15;54(2):1755-62
references: 20723605
references: Brain Cogn. 2006 Aug;61(3):243-8
references: 16510224