title: Cooperative protein transport in cellular organelles.
abstract: Compartmentalization into biochemically distinct organelles constantly exchanging material is one of the hallmarks of eukaryotic cells. In the most naive picture of interorganelle transport driven by concentration gradients, concentration differences between organelles should relax. We determine the conditions under which cooperative transport, i.e., based on molecular recognition, allows for the existence and maintenance of distinct organelle identities. Cooperative transport is also shown to control the flux of material transiting through a compartmentalized system, dramatically increasing the transit time under high incoming flux. By including chemical processing of the transported species, we show that this property provides a strong functional advantage to a system responsible for protein maturation and sorting.
authors: Laboratoire Gulliver (CNRS UMR 7083), ESPCI, 10 rue Vauquelin, F-75231 Paris Cedex 05, France. serge.dmitrieff@espci.fr
authors: S
authors: S
authors: Dmitrieff
authors: P
authors: P
authors: Sens