title: [In vitro and in vivo efficacy of Ingavirin against strains of pandemic influenza virus A(H1N1/09)v].
abstract: OBJECTIVE
  To study efficacy of Ingavirin in vitro and in vivo against strains of pandemic influenza virus A(H1N1/09)v and influenza virus A(H5N1) and A(H3N2).
  
  
  METHODS
  Changes in hemagglutinating and cytopathic activity of influenza virus strains A(H1N1/09)v, A(H5N1) and A(H3N2) during their incubation in the presence of Ingavirin or Remantadin on MDCK cell culture were studied. In mice infected by influenza strains A(H1N1/09)v and A(H3N2) and orally treated with Ingavirin, Tamiflu or Remantadin virus titers in lungs were measured.
  
  
  RESULTS
  There was decrease in hemagglutinating and cytopathic activity of influenza virus strains after incubation with Ingavirin in vitro. Ingavirin effectively inhibited reproduction of influenza virus strains A(H1N1/09)v and A(H3N2) in lungs of infected mice. Titers of these strains in lung homogenates decreased when Ingavirin was orally administered to infected mice.
  
  
  CONCLUSIONS
  Strains of influenza virus A(H1N1/09)v were susceptible to Ingavirin and Tamiflu but resistant to Remantadin. Reference strains of A(H5N1) and A(H3N2) were susceptible to Ingavirin, Tamiflu and Remantadin.
authors: L N
authors: LN
authors: Shishkina
authors: V E
authors: VE
authors: Nebol'sin
authors: A S
authors: AS
authors: Kabanov
authors: M O
authors: MO
authors: Skarnovich
authors: N A
authors: NA
authors: Mazurkova
authors: A A
authors: AA
authors: Sergeev
authors: O A
authors: OA
authors: Serova
authors: E A
authors: EA
authors: Stavskiĭ
authors: I G
authors: IG
authors: Drozdov