title: Spatial Memory Performance Associated with Measures of Immune Function in Elderly Female Rhesus Macaques.
abstract: We recently reported that in aged female rhesus macaques, spatial learning and memory correlates with circadian sleep-wake measures and hippocampal muscarinic type 1 (M(1)) receptor binding. To investigate if spatial memory also correlates with measures of immune function, we now assessed the magnitude of the adaptive immune response to vaccination in the same old female rhesus macaques. Cognitively characterized animals were classified as good spatial performers (GSP) or poor spatial performers (PSP) based on performance in the Spatial Foodport maze. The GSP group had higher frequency of CD8, but not CD4, interferon-γ (IFN-γ) producing cells following vaccination compared to the PSP group, suggesting a stronger CD8 T cell response in the GSP group. In addition, the number of CD-8 IFN-γ positive cells correlated with measures of sleep quality. Interestingly, the PSP group had a significantly higher antibody titer compared to the GSP group, and antibody titer negatively correlated with day-time activity. Thus, in aged female rhesus macaques, superior cognitive performance is correlated with a more robust CD8 T cell response but a reduced antibody response to vaccination.
authors: Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239.
authors: Gwendolen E
authors: GE
authors: Haley
authors: Henryk F
authors: HF
authors: Urbanski
authors: Steven G
authors: SG
authors: Kohama
authors: Ilhem
authors: I
authors: Messaoudi
authors: Jacob
authors: J
authors: Raber
references: Exp Neurol. 2009 May;217(1):55-62
references: 19416674
references: Mol Psychiatry. 2010 Apr;15(4):415-25
references: 19636313
references: Chronobiol Int. 1999 Sep;16(5):581-622
references: 10513884
references: J Med Virol. 2004 Jun;73(2):295-9
references: 15122807
references: J Neurosci. 1996 Mar 15;16(6):2027-33
references: 8604047
references: Front Biosci. 2004 Sep 01;9:2063-85
references: 15353271
references: J Comp Pathol. 2010 Jan;142 Suppl 1:S39-44
references: 19897208
references: Sleep Med. 2010 Mar;11(3):289-94
references: 20156702
references: Immunol Rev. 2005 Dec;208:154-68
references: 16313347
references: Neurobiol Aging. 1988 Sep-Dec;9(5-6):657-66
references: 3145465
references: Pharmacol Biochem Behav. 2002 May;72(1-2):45-53
references: 11900768
references: Dementia. 1996 May-Jun;7(3):128-34
references: 8740626
references: JAMA. 2002 Sep 25;288(12):1471-2
references: 12243633
references: Transpl Int. 2009 Nov;22(11):1041-50
references: 19624493
references: Proc Natl Acad Sci U S A. 2004 May 25;101(21):8180-5
references: 15141078
references: J Exp Psychol Appl. 2000 Sep;6(3):236-49
references: 11014055
references: Mech Ageing Dev. 2009 Jan-Feb;130(1-2):40-5
references: 18671998
references: Trends Immunol. 2009 Jul;30(7):351-9
references: 19540808
references: Curr Opin Immunol. 2009 Aug;21(4):418-24
references: 19570667
references: Life Sci. 2007 May 30;80(24-25):2330-3
references: 17286988
references: J Neuroimmunol. 2007 Aug;188(1-2):80-5
references: 17586055
references: Chronobiol Int. 1986;3(2):91-100
references: 2824075
references: Q J Exp Psychol A. 2000 Feb;53(1):271-9
references: 10718074
references: Behav Sleep Med. 2008;6(1):32-54
references: 18412036
references: Psychosom Med. 2003 Sep-Oct;65(5):831-5
references: 14508028
references: Sleep. 2000 Dec 15;23(8):1067-73
references: 11145321
references: Immun Ageing. 2005 Nov 04;2:14
references: 16271143
references: Rejuvenation Res. 2008 Oct;11(5):903-13
references: 18803478
references: Trends Immunol. 2008 Oct;29(10):455-63
references: 18789764
references: J Neurosci. 2002 Feb 1;22(3):635-8
references: 11826092
references: Semin Neurol. 2007 Feb;27(1):86-92
references: 17226745
references: Hum Psychopharmacol. 2008 Jul;23(5):425-36
references: 18421801
references: Nat Neurosci. 2006 Feb;9(2):268-75
references: 16415867
references: Cancer Immunol Immunother. 2006 Aug;55(8):981-6
references: 16333622
references: Brain Behav Immun. 2008 Aug;22(6):861-9
references: 18249087
references: Neurology. 2009 Dec 8;73(23):1975-81
references: 19890073
references: Curr Neurol Neurosci Rep. 2003 May;3(3):215-22
references: 12691626
references: Aging Clin Exp Res. 2009 Jun;21(3):201-9
references: 19571643
references: Auton Autacoid Pharmacol. 2006 Jul;26(3):219-33
references: 16879488
references: Nat Med. 1998 Nov;4(11):1313-7
references: 9809557
references: Trends Neurosci. 2009 Jul;32(7):367-75
references: 19520437
references: Physiology (Bethesda). 2008 Apr;23:64-74
references: 18400689
references: Age (Dordr). 2011 Sep;33(3):309-20
references: 20890730
references: Nature. 2002 Feb 28;415(6875):1030-4
references: 11875571
references: Clin Interv Aging. 2007;2(4):605-10
references: 18225461
references: J Neurosci. 2008 Jul 30;28(31):7797-807
references: 18667612
references: Exp Gerontol. 2007 Aug;42(8):719-32
references: 17368996
references: Exp Gerontol. 2001 Feb;36(2):267-82
references: 11226742
references: Ann N Y Acad Sci. 2007 Nov;1116:360-75
references: 18083938
references: J Neuroimmunol. 2005 Jul;164(1-2):66-75
references: 15913791