title: Titrating autophagy in cardiac plasticity.
abstract: The heart is a highly plastic organ. In a recent study, we found that autophagy is a required element in load-induced cardiomyocyte growth; when autophagy is suppressed, the heart does not grow. Conversely, afterload stress triggers a transient increase in cardiomyocyte autophagic activity which settles to a new--higher--baseline once the heart has re-achieved steady-state size. Our work went on to decipher the role of histone deacetylases in this biology.
authors: Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Dian J
authors: DJ
authors: Cao
authors: Joseph A
authors: JA
authors: Hill
references: Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4123-8
references: 21367693