title: COMT and age at onset in mood disorders: a replication and extension study.
abstract: Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG+AG genotypes were more represented in the subgroup of early onset MD patients (p=0.04). Additionally, we observed an association between rs737865 alleles and early onset MD (p=0.04). Rs4680 genotype was associated with early onset BD as well (p=0.01). In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes.
authors: Fonds de la Recherche Scientifique (FNRS), Laboratoire de Neurologie Expé rimentale, Université Libre de Bruxelles, Belgium.
authors: Isabelle
authors: I
authors: Massat
authors: Neslihan Aygun
authors: NA
authors: Kocabas
authors: Concetta
authors: C
authors: Crisafulli
authors: Alberto
authors: A
authors: Chiesa
authors: Raffaella
authors: R
authors: Calati
authors: Sylvie
authors: S
authors: Linotte
authors: Siegfried
authors: S
authors: Kasper
authors: Martin
authors: M
authors: Fink
authors: Irina
authors: I
authors: Antonijevic
authors: Carlos
authors: C
authors: Forray
authors: Lenore
authors: L
authors: Snyder
authors: Joseph
authors: J
authors: Bollen
authors: Joseph
authors: J
authors: Zohar
authors: Diana
authors: D
authors: De Ronchi
authors: Daniel
authors: D
authors: Souery
authors: Alessandro
authors: A
authors: Serretti
authors: Julien
authors: J
authors: Mendlewicz