title: Intranuclear inclusions in epithelial cells of benign proliferative breast lesions.
abstract: OBJECTIVE
  To document and clarify the nature of intranuclear inclusions of luminal epithelium in benign proliferative breast lesions.
  
  
  RESULTS
  Five benign breast lesions were selected which showed intranuclear inclusions within epithelial cells on light microscopy. Following confirmation of their luminal epithelial (non-myoepithelial) localisation by immunohistochemistry, ultrastructural examination was performed with the following observations: (1) presence of deep nuclear indentations occasionally verging on nuclear inclusions; (2) inclusions with features of helioid bodies; and (3) a morphological spectrum of helioid bodies and their focal coexistence.
  
  
  CONCLUSIONS
  Intranuclear inclusions of breast epithelium are likely of cytoplasmic origin. Helioid bodies may be formed by a stepwise process, the nature of which needs further study.
authors: Department of Pathology, Singapore General Hospital, Singapore.
authors: Oi
authors: O
authors: Harada
authors: Rebecca
authors: R
authors: Hoe
authors: Jieyan
authors: J
authors: Lin
authors: Aye Aye
authors: AA
authors: Thike
authors: Ana Richelia
authors: AR
authors: Jara-Lazaro
authors: Fredrik
authors: F
authors: Petersson
authors: Puay Hoon
authors: PH
authors: Tan