title: pH-Operated mechanized porous silicon nanoparticles.
abstract: Porous silicon nanoparticles (PSiNPs) were synthesized by silver-assisted electroless chemical etching of silicon nanowires generated on a silicon wafer. The rod-shaped particles (200-400 nm long and 100-200 nm in diameter) were derivatized with a cyclodextrin-based nanovalve that was closed at the physiological pH of 7.4 but open at pH <6. Release profiles in water and tissue culture media showed that no cargo leaked when the valves were closed and that release occurred immediately after acidification. In vitro studies using human pancreatic carcinoma PANC-1 cells proved that these PSiNPs were endocytosed and carried cargo molecules into the cells and released them in response to lysosomal acidity. These studies show that PSiNPs can serve as an autonomously functioning delivery platform in biological systems and open new possibilities for drug delivery.
authors: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
authors: Min
authors: M
authors: Xue
authors: Xing
authors: X
authors: Zhong
authors: Zory
authors: Z
authors: Shaposhnik
authors: Yongquan
authors: Y
authors: Qu
authors: Fuyuhiko
authors: F
authors: Tamanoi
authors: Xiangfeng
authors: X
authors: Duan
authors: Jeffrey I
authors: JI
authors: Zink
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