title: Microbubble-based synchrotron radiation phase contrast imaging: basic study and angiography applications.
abstract: The purpose of the study was to evaluate the feasibility of microbubbles as phase contrast imaging (PCI) agents for angiography applications. The hypothesis was that the introduction of microbubbles into tissue produces a significant change in the refractive index and highlights the lumen of the vessel in PCI. The absorption and phase contrast images of commercially available microbubbles were obtained and compared in vitro. A further increase in contrast was observed in PCI. Microbubbles highlighted the lumen of the renal microvessels, acting as a positive contrast medium in ex vivo imaging. In addition, home-made microbubbles with larger diameters were introduced for image contrast enhancement in living tumor-bearing mice, demonstrating the feasibility of microbubble-based x-ray phase-contrast imaging for tumor vasculature in vivo.
authors: Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, People's Republic of China.
authors: Rongbiao
authors: R
authors: Tang
authors: Yan
authors: Y
authors: Xi
authors: Wei-Min
authors: WM
authors: Chai
authors: Yongting
authors: Y
authors: Wang
authors: Yongjing
authors: Y
authors: Guan
authors: Guo-Yuan
authors: GY
authors: Yang
authors: Honglan
authors: H
authors: Xie
authors: Ke-Min
authors: KM
authors: Chen