title: Basophils, IgE, and autoantibody-mediated kidney disease.
abstract: Basophils are of interest in immunology due to their ability to produce a Th2-signature cytokine, IL-4, following activation. A new understanding of the role of basophils in immunity shows novel functions at a cellular level through which basophils influence adaptive immunity. This review summarizes new advances in basophil biology and discusses new roles for basophils in human disease, especially in the mediation of the pathogenesis of lupus nephritis. Recently, basophils have been shown to contribute to self-reactive Ab production in systemic lupus erythematosus and may enhance pre-existing loss of B cell tolerance, suggesting that basophils, IL-4, and IgE mediate the pathogenesis of lupus nephritis by promoting the Th2 environment and activating autoreactive B cells. In addition to envisaging exciting therapeutic prospects, these novel findings open the way for the study of basophils in other autoimmune and renal diseases.
authors: Department of Internal Medicine, Hospital Clinic, Institut d'Investigacions Bimoèdiques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain.
authors: Xavier
authors: X
authors: Bosch
authors: Francisco
authors: F
authors: Lozano
authors: Ricard
authors: R
authors: Cervera
authors: Manuel
authors: M
authors: Ramos-Casals
authors: Booki
authors: B
authors: Min
references: J Exp Med. 2004 Aug 16;200(4):507-17
references: 15314076
references: J Exp Med. 1989 Aug 1;170(2):467-79
references: 2474054
references: Ann N Y Acad Sci. 2010 Jan;1183:211-21
references: 20146717
references: Nat Immunol. 2009 Feb;10(2):214-22
references: 19098920
references: J Immunol. 2009 Sep 1;183(5):3033-9
references: 19667092
references: Nat Immunol. 2009 Jul;10(7):697-705
references: 19465906
references: Int Immunol. 2008 Sep;20(9):1201-9
references: 18632726
references: Kidney Int. 2009 Dec;76(11):1142-7
references: 19692999
references: J Immunol. 1982 Dec;129(6):2407-12
references: 7142697
references: J Immunol. 2005 Dec 1;175(11):7185-92
references: 16301622
references: Int Immunol. 2008 Aug;20(8):1019-30
references: 18550585
references: J Leukoc Biol. 2009 Oct;86(4):769-78
references: 19451398
references: Trends Mol Med. 2010 Feb;16(2):47-57
references: 20138006
references: J Immunol. 2007 May 15;178(10):6023-7
references: 17475824
references: Immunity. 2005 Aug;23(2):191-202
references: 16111637
references: J Immunol. 2005 Aug 1;175(3):1867-75
references: 16034130
references: J Immunol. 2002 May 1;168(9):4701-10
references: 11971020
references: Immunity. 2009 Apr 17;30(4):533-43
references: 19362019
references: Immunity. 2010 Sep 24;33(3):364-74
references: 20817571
references: Nat Immunol. 2009 Aug;10(8):889-98
references: 19561614
references: Exp Dermatol. 2006 Nov;15(11):855-64
references: 17002682
references: Immunity. 2007 Feb;26(2):205-13
references: 17306569
references: Clin Exp Immunol. 1998 Jan;111(1):136-43
references: 9472673
references: J Exp Med. 2010 Sep 27;207(10):2089-96
references: 20819926
references: Trends Immunol. 2008 Mar;29(3):110-5
references: 18249583
references: Lab Invest. 2008 Nov;88(11):1134-42
references: 18975389
references: Blood. 2007 Apr 1;109(7):2921-7
references: 17132717
references: Nature. 1993 Sep 23;365(6444):340-3
references: 7690905
references: Allergol Int. 2009 Mar;58(1):21-8
references: 19153533
references: Nat Immunol. 2008 Dec;9(12):1333-9
references: 19008933
references: Immunity. 2004 Mar;20(3):267-77
references: 15030771
references: Arthritis Rheum. 2001 Sep;44(9):2097-106
references: 11592372
references: Immunity. 2004 May;20(5):517-27
references: 15142521
references: J Leukoc Biol. 2001 Jul;70(1):113-20
references: 11435493
references: J Immunol. 2004 Jun 15;172(12):7734-43
references: 15187157
references: J Allergy Clin Immunol. 1979 Aug;64(2):79-89
references: 313413
references: Immunity. 2001 Jun;14(6):791-800
references: 11420048
references: Nat Med. 2010 Jun;16(6):701-7
references: 20512127
references: Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18105-10
references: 16330751
references: J Exp Med. 2010 Sep 27;207(10):2097-111
references: 20819925
references: J Exp Med. 2004 Jun 7;199(11):1491-502
references: 15173205
references: Blood. 2005 Sep 15;106(6):2011-7
references: 15914553
references: Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13962-6
references: 10570181
references: Nat Immunol. 2009 Jul;10(7):706-12
references: 19465908
references: N Engl J Med. 2008 Feb 28;358(9):929-39
references: 18305268
references: Immunity. 2001 Dec;15(6):985-95
references: 11754819
references: J Immunol. 2003 May 1;170(9):4818-25
references: 12707364
references: Clin Exp Allergy. 2010 Aug;40(8):1194-202
references: 20545698
references: Lancet. 2011 Feb 26;377(9767):721-31
references: 21296403
references: J Immunol. 2007 Feb 15;178(4):2579-88
references: 17277168
references: Curr Opin Immunol. 2009 Dec;21(6):606-11
references: 19683910
references: Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2586-91
references: 20133791
references: Nat Med. 2010 Jun;16(6):635-6
references: 20526313
references: Int Arch Allergy Immunol. 2010;152(4):401-6
references: 20197682
references: J Clin Invest. 2010 Aug;120(8):2867-75
references: 20664169
references: J Investig Dermatol Symp Proc. 2001 Nov;6(2):139-40
references: 11764301
references: J Immunol. 1982 Aug;129(2):790-6
references: 7086142
references: J Immunol. 2009 Mar 1;182(5):2835-41
references: 19234178
references: J Exp Med. 2006 Feb 20;203(2):393-400
references: 16446381
references: Immunol Rev. 2007 Jun;217:19-37
references: 17498049
references: Braz J Med Biol Res. 2004 Oct;37(10):1497-501
references: 15448870
references: J Immunol. 1990 Oct 15;145(8):2500-6
references: 2145362
references: J Allergy Clin Immunol. 2004 Feb;113(2):297-302
references: 14767445
references: Curr Biol. 2001 Jan 9;11(1):34-8
references: 11166177
references: J Intern Med. 2009 Jun;265(6):644-52
references: 19493058
references: Nat Immunol. 2008 Jul;9(7):733-42
references: 18516038
references: Clin Exp Rheumatol. 2003 Jan-Feb;21(1):117-21
references: 12673903
references: J Immunol. 2009 Sep 15;183(6):3591-7
references: 19684081
references: N Engl J Med. 2010 Sep 9;363(11):1080-2
references: 20825323
references: Nat Immunol. 2009 Jul;10(7):713-20
references: 19465907
references: Int Arch Allergy Immunol. 1996 Jul;110(3):261-71
references: 8688673
references: J Leukoc Biol. 2003 Jan;73(1):165-71
references: 12525574
references: J Immunol. 2000 Jan 15;164(2):589-95
references: 10623799
references: J Immunol. 2010 Feb 1;184(3):1143-7
references: 20038645
references: Vet Parasitol. 1984 Oct;16(1-2):147-65
references: 6543047
references: J Allergy Clin Immunol. 2005 Feb;115(2):295-301
references: 15696084
references: Proc Natl Acad Sci U S A. 1990 Feb;87(4):1421-5
references: 2106135
references: Nature. 1998 Mar 5;392(6671):90-3
references: 9510253
references: J Clin Invest. 2003 Oct;112(8):1211-22
references: 14561706
references: Annu Rev Immunol. 2010;28:445-89
references: 20192806
references: J Allergy Clin Immunol. 2000 Mar;105(3):432-7
references: 10719290
references: Nat Immunol. 2008 Mar;9(3):310-8
references: 18300366
references: J Investig Med. 2001 Mar;49(2):157-65
references: 11288756
references: J Immunol. 2009 Sep 15;183(6):3652-60
references: 19710468