title: Clinical analysis of skin lesions in 796 Chinese HIV- positive patients.
abstract: Skin lesions are often associated with human immunodeficiency virus (HIV) infection, reflecting the immunocompromised status of the individual. We investigated the relationship between skin lesions and immune function in a retrospective study of 796 Chinese HIV patients with and without highly active antiretroviral therapy (HAART). Of the 651 patients who had not received HAART, we found that 531 (81.6%) had apparent skin lesions. The incidence of infectious skin diseases (fungi, viruses, bacteria, spirochetes and parasites) and non-infectious skin diseases (excluding skin cancer) was 68.8% and 34.9%, respectively. Mean CD4(+) T-cell counts and CD4(+)/CD8(+) ratios were lower in patients with skin lesions than in patients without lesions (178 ± 96/µl vs. 306 ± 189/µl (p < 0.05) and 0.22 vs. 0.34 (p < 0.01), respectively). Candidiasis (25.8%), eczema (19.2%), nodular prurigo (13.8%), dermatophyte infections (10.6%) and herpes zoster (9.4%) were most common in Chinese patients with HIV. Among the 145 patients who had started HAART, there was a significantly lower prevalence of skin diseases (29.0%), although drug eruptions (12.4%) were more commonly observed. These findings indicate that HAART often reduces the incidence of infectious and non-infectious skin lesions in patients with HIV, but can itself be the cause of drug eruptions.
authors: STD and AIDS Clinical Center, Beijing Youan Hospital, Capital Medical University, China.
authors: Xiao-jie
authors: XJ
authors: Huang
authors: Hai-ying
authors: HY
authors: Li
authors: De-xi
authors: DX
authors: Chen
authors: Xi-cheng
authors: XC
authors: Wang
authors: Zai-chun
authors: ZC
authors: Li
authors: Ya-song
authors: YS
authors: Wu
authors: Tong
authors: T
authors: Zhang
authors: Yan-qing
authors: YQ
authors: Gao
authors: Hao
authors: H
authors: Wu