title: Colonic phasic motor activity is stronger in patients with repaired anorectal malformations than patients with severe colonic dismotility.
abstract: In this study, colonic manometry studies of the patients with repaired anorectal malformations (ARM) were compared with those of patients with severe colonic dismotility due to chronic constipation (CC) and acute pseudo-obstruction (PSO). The patients with repaired ARM were accepted as group #1 (n=10). The patients with CC and acute PSO composed group #2 (n=10). Eight-channel water perfused catheter was inserted into the colon under sedation. Colonic activity was recorded in three phases including fasting, after meal and after bisacodyl installation. The results were assessed by Pearson χ(2) test, P<.05 was considered statistically significant. Mean age was 9.6 and 12.1 in groups #1 and #2, respectively. Ninety-five per cent of all patients had propagated contractions (PCs) and 20% and 40% of the patients in group #1 had PCs during fasting and after meal, respectively. These contractions were seen 30% and 70% of the patients in group #2, but no statistical difference was found between the groups. PCs after bisacodyl were observed 90% and 40% of the patients in groups #1 and #2, respectively, and this difference was statistically significant (P=.019). In this study, the prominent difference between the groups was found in response to intraluminal stimulation. This finding may indicate that the colon of the patients with ARM has more capacity to develop PCs by peripheral stimuli and more regular enteric nervous integrity.
authors: Gazi University Medical Faculty Departments of Pediatric Surgery and Pediatric Gastroenterology, Ankara, Turkey.
authors: Billur
authors: B
authors: Demirogullari
authors: Sinan
authors: S
authors: Sari
authors: Odul
authors: O
authors: Egritas
authors: Cuneyt
authors: C
authors: Karakus
authors: Io
authors: I
authors: Ozen
authors: Kaan
authors: K
authors: Sonmez
authors: Buket
authors: B
authors: Dalgic
authors: Nuri
authors: N
authors: Kale
authors: A Can
authors: AC
authors: Basaklar
references: Gut. 1993 Jun;34(6):803-7
references: 8314513
references: Am J Surg. 2000 Nov;180(5):370-6
references: 11137690
references: J Pediatr Gastroenterol Nutr. 2009 Jan;48(1):22-9
references: 19172119
references: J Pediatr Surg. 2006 Apr;41(4):730-6; discussion 730-6
references: 16567185
references: J Pediatr Surg. 2008 Oct;43(10):1839-43
references: 18926217
references: J Pediatr Surg. 2004 Mar;39(3):352-9; discussion 352-9
references: 15017551
references: Gastroenterology. 2000 Jan;118(1):14-21
references: 10611149
references: Gut. 2006 Jan;55(1):41-6
references: 16041063
references: Br Med J. 1948 Oct 9;2(4579):671-3
references: 18886657
references: Dig Dis Sci. 1999 Jul;44(7):1288-92
references: 10489907
references: J Pediatr Surg. 2001 Dec;36(12):1757-63
references: 11733901
references: J Pediatr. 1992 May;120(5):690-5
references: 1578302
references: Orphanet J Rare Dis. 2007 May 04;2:22
references: 17480225
references: J Pediatr Surg. 2004 Jun;39(6):795-9
references: 15185198