title: Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities.
abstract: Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a prominent candidate for further studies and drug development. In this review, we briefly investigate molecular events and cell-specific activities of this chemical in relation to cytochrome c, nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), signal transduction and activation of transcription (STAT), reactive oxygen species (ROS), TCP, HDACs, microtubules, and inflammasomes. This paper reports that parthenolide shows strong NF-κB- and STAT-inhibition-mediated transcriptional suppression of pro-apoptotic genes. This compound acts both at the transcriptional level and by direct inhibition of associated kinases (IKK-β). Similarly, this review discusses parthenolide-induced ROS-mediated apoptosis of tumor cells via the intrinsic apoptotic signaling pathway. The unique ability of this compound to not harm normal cells but at the same time induce sensitization to extrinsic as well as intrinsic apoptosis signaling in cancer cells provides an important, novel therapeutic strategy for treatment of cancer and inflammation-related disorders.
authors: Department of Microbiology, School of Medicine and Brain Korea 21 Program, Jeju National University, Jeju, Jeju-Do, South Korea. vivek_mathema@hotmail.com
authors: Vivek Bhakta
authors: VB
authors: Mathema
authors: Young-Sang
authors: YS
authors: Koh
authors: Balkrishna Chand
authors: BC
authors: Thakuri
authors: Mika
authors: M
authors: Sillanpää
references: J Virol. 2011 May;85(9):4167-72
references: 21289120
references: Prostate. 2006 Jun 15;66(9):954-65
references: 16541425
references: Chem Biol. 2001 Aug;8(8):759-66
references: 11514225
references: Cancer Lett. 2007 Aug 28;254(1):119-27
references: 17470383
references: Carcinogenesis. 2007 Jan;28(1):215-22
references: 16887864
references: Cancer Cell Int. 2005 Jul 24;5(1):22
references: 16042792
references: Nat Rev Cancer. 2006 Jan;6(1):38-51
references: 16397526
references: Cell Death Differ. 2004 Jul;11 Suppl 1:S86-96
references: 15105837
references: Cell Chromosome. 2004 Jan 13;3(1):1
references: 14720303
references: Int J Cancer. 2004 Nov 10;112(3):365-75
references: 15382060
references: Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13012-7
references: 9789032
references: Nat Immunol. 2008 Aug;9(8):847-56
references: 18604214
references: Oncogene. 2004 Sep 23;23(44):7330-44
references: 15286701
references: Antimicrob Agents Chemother. 2011 Mar;55(3):961-6
references: 21135175
references: J Med Food. 2006 Spring;9(1):55-61
references: 16579729
references: Eur J Cell Biol. 2001 Aug;80(8):554-61
references: 11561906
references: Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9035-40
references: 18577586
references: Nature. 2006 Mar 9;440(7081):237-41
references: 16407889
references: Leukemia. 2006 Jun;20(6):1073-9
references: 16628188
references: Thromb Res. 2011 May;127(5):426-34
references: 21272923
references: Curr Med Chem Anticancer Agents. 2005 Jan;5(1):65-71
references: 15720262
references: Annu Rev Immunol. 2009;27:229-65
references: 19302040
references: J Dig Dis. 2009 Aug;10(3):172-80
references: 19659784
references: Int Rev Immunol. 1998;16(5-6):457-99
references: 9646173
references: Oncogene. 2004 Jun 17;23(28):4921-9
references: 15077160
references: Med Hypotheses. 2006;66(4):832-43
references: 16242247
references: Clin Cancer Res. 2010 Nov 1;16(21):5189-99
references: 20884624
references: Arch Biochem Biophys. 2000 Aug 15;380(2):309-18
references: 10933886
references: Neurochem Res. 2000 Jan;25(1):11-8
references: 10685599
references: Nat Rev Drug Discov. 2009 Jan;8(1):33-40
references: 19116625
references: Br J Haematol. 2008 Dec;143(5):661-71
references: 19036014
references: Biofactors. 1998;8(1-2):1-5
references: 9699000
references: Blood. 2005 Jun 1;105(11):4163-9
references: 15687234
references: J Cell Physiol. 2011 Jun;226(6):1632-41
references: 21413021
references: PLoS Pathog. 2009 Dec;5(12):e1000510
references: 20041168
references: Biochem Biophys Res Commun. 2000 Jan 7;267(1):329-33
references: 10623619
references: Cancer Res. 2007 Apr 1;67(7):3371-8
references: 17409447
references: Biochem Biophys Res Commun. 2005 Jul 1;332(2):321-5
references: 15910740
references: J Biol Chem. 2010 Mar 26;285(13):9792-9802
references: 20093358
references: Expert Opin Ther Targets. 2007 Oct;11(10):1355-65
references: 17907964
references: J Inflamm (Lond). 2005 Jun 29;2:6
references: 15987517
references: Annu Rev Immunol. 2000;18:621-63
references: 10837071
references: Folia Histochem Cytobiol. 2008;46(2):129-35
references: 18519227
references: Cancer Lett. 2004 May 28;208(2):143-53
references: 15142672
references: Apoptosis. 2006 Dec;11(12):2225-35
references: 17051330
references: Br J Haematol. 2010 Oct;151(1):70-83
references: 20701602
references: Purinergic Signal. 2009 Jun;5(2):129-37
references: 19212823
references: J Zhejiang Univ Sci B. 2009 Jul;10(7):528-35
references: 19585671
references: Chem Biol. 2007 Jul;14(7):813-23
references: 17656318
references: Free Radic Biol Med. 2008 Sep 1;45(5):549-61
references: 18544350
references: Cancer Res. 2001 Jul 1;61(13):5024-7
references: 11431336
references: Cancer Lett. 2004 Aug 10;211(2):175-88
references: 15219941
references: J Thromb Haemost. 2009 Jan;7(1):182-9
references: 18983509
references: Cell. 1998 Aug 21;94(4):491-501
references: 9727492
references: Cancer Res. 2010 Apr 1;70(7):2880-90
references: 20233868
references: Carcinogenesis. 2004 Nov;25(11):2089-100
references: 15240510
references: Clin Cancer Res. 2008 Dec 15;14(24):8102-11
references: 19088025