title: Gonadotropin-releasing-hormone (gn-rh) receptor in the reproductive-tract tumor - physiological-role and signal-transduction pathway.
abstract: Gonadotropin-releasing hormoen (Gn-RH) analogs have been used in the therapy of the endocrine-dependent cancers including the repductive tract-originated tumors. Gn-RH receptor and its transmembrane signaling pathways have been demonstrated in a high proportion of these tumors. The demonstration of existence of receptors for a hormone can better predict hormonal dependency, and might be a first step towards an effective hormonal treatment. These findings suggest the merit of further therapeutic investigations of Gn-RH analogs alone or in combination with traditional therapies in the management of Gn-RH receptor-positive tumors.
authors: A
authors: A
authors: Imai
authors: S
authors: S
authors: Horibe
authors: H
authors: H
authors: Takagi
authors: T
authors: T
authors: Fuseya
authors: T
authors: T
authors: Furui
authors: T
authors: T
authors: Tamaya