title: Oligomerization and toxicity of Aβ fusion proteins.
abstract: This study has found that the Maltose binding protein Aβ42 fusion protein (MBP-Aβ42) forms soluble oligomers while the shorter MBP-Aβ16 fusion and control MBP did not. MBP-Aβ42, but neither MBP-Aβ16 nor control MBP, was toxic in a dose-dependent manner in both yeast and primary cortical neuronal cells. This study demonstrates the potential utility of MBP-Aβ42 as a reagent for drug screening assays in yeast and neuronal cell cultures and as a candidate for further Aβ42 characterization.
authors: CSIRO Materials Science and Engineering and the Preventive Health Flagship, Parkville, Victoria, Australia. Jo.Caine@csiro.au
authors: Joanne M
authors: JM
authors: Caine
authors: Prashant R
authors: PR
authors: Bharadwaj
authors: Sonia E
authors: SE
authors: Sankovich
authors: Giuseppe D
authors: GD
authors: Ciccotosto
authors: Victor A
authors: VA
authors: Streltsov
authors: Jose
authors: J
authors: Varghese