title: Association between gene alteration and drug-sensitivity in human lung-carcinoma cell-lines.
abstract: The association between gene alterations (K-ras, p53, N-myc) and drug resistance (CDDP, CBDCA, MMC, Epi-ADM) was examined in 29 human lung carcinoma cell lines using the in vitro MTT assay. There was no significant difference in the IC50 values of four drugs between K-ras or p53 gene alteration-positive and -negative groups. However, two cell lines with N-myc amplification showed a higher resistance than those without N-myc amplification to all four drugs. This preliminary study suggests that K-ras or p53 gene alteration is probably not related to drug resistance, but N-myc might be.
authors: Y
authors: Y
authors: Mizushima
authors: T
authors: T
authors: Kashii
authors: M
authors: M
authors: Kobayashi