title: Circulating levels of cell adhesion molecule L1 as a prognostic marker in gastrointestinal stromal tumor patients.
abstract: BACKGROUND
  L1 cell adhesion molecule (CD171) is expressed in many malignant tumors and its expression correlates with unfavourable outcome. It thus represents a target for tumor diagnosis and therapy. An earlier study conducted by our group identified L1 expression levels in primary gastrointestinal stromal tumors (GIST) as a prognostic marker. The aim of the current study was to compare L1 serum levels of GIST patients with those of healthy controls and to determine whether levels of soluble L1 in sera could serve as a prognostic marker.
  
  
  METHODS
  Using a sensitive enzyme-linked immunosorbent assay (ELISA), soluble L1 was measured in sera of 93 GIST patients und 151 healthy controls. Soluble L1 levels were then correlated with clinicopathological data.
  
  
  RESULTS
  Median levels of soluble L1 were significantly higher (p < 0.001; Mann-Whitney U test) in sera of GIST patients compared to healthy individuals. Median soluble L1 levels were particularly elevated in patients with recurrence and relapse (p < 0.05; Mann Whitney U test).
  
  
  CONCLUSIONS
  These results suggest that high soluble L1 levels predict poor prognosis and may thus be a promising tumor marker that can contribute to individualise therapy.
authors: Department of General, Visceral, and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. hilke.zander@zmnh.uni-hamburg.de
authors: Hilke
authors: H
authors: Zander
authors: Tamina
authors: T
authors: Rawnaq
authors: Max
authors: M
authors: von Wedemeyer
authors: Michael
authors: M
authors: Tachezy
authors: Miriam
authors: M
authors: Kunkel
authors: Gerrit
authors: G
authors: Wolters
authors: Maximilian
authors: M
authors: Bockhorn
authors: Melitta
authors: M
authors: Schachner
authors: Jakob R
authors: JR
authors: Izbicki
authors: Jussuf
authors: J
authors: Kaifi
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