title: Fluorescent magnetic hybrid nanoprobe for multimodal bioimaging.
abstract: A fluorescent magnetic hybrid imaging nanoprobe (HINP) was fabricated by the conjugation of superparamagnetic Fe3O4 nanoparticles and visible light emitting (∼600 nm) fluorescent CdTe/CdS quantum dots (QDs). The assembly strategy used the covalent linking of the oxidized dextran shell of magnetic particles to the glutathione ligands of QDs. The synthesized HINP formed stable water-soluble colloidal dispersions. The structure and properties of the particles were characterized by transmission electron and atomic force microscopy, energy dispersive x-ray analysis and inductively coupled plasma optical emission spectroscopy, dynamic light scattering analysis, optical absorption and photoluminescence spectroscopy, and fluorescent imaging. The luminescence imaging region of the nanoprobe was extended to the near-infrared (NIR) (∼800 nm) by conjugation of the superparamagnetic nanoparticles with synthesized CdHgTe/CdS QDs. Cadmium, mercury based QDs in HINP can be easily replaced by novel water-soluble glutathione stabilized AgInS2/ZnS QDs to present a new class of cadmium-free multimodal imaging agents. The observed NIR photoluminescence of fluorescent magnetic nanocomposites supports their use for bioimaging. The developed HINP provides dual-imaging channels for simultaneous optical and magnetic resonance imaging.
authors: Department of Chemistry, Vanderbilt University, Station B 351822, Nashville, TN 37235, USA.
authors: Dmitry
authors: D
authors: Koktysh
authors: Vanessa
authors: V
authors: Bright
authors: Wellington
authors: W
authors: Pham
references: Science. 2005 Jan 28;307(5709):538-44
references: 15681376
references: Int J Mol Sci. 2008 Oct;9(10):2044-61
references: 19325735
references: Proc Natl Acad Sci U S A. 1979 Jul;76(7):3392-6
references: 16592679
references: Nat Med. 2007 Mar;13(3):372-7
references: 17322898
references: J Am Chem Soc. 2007 Oct 17;129(41):12388-9
references: 17887678
references: Chem Commun (Camb). 2009 Jul 28;(28):4188-90
references: 19585016
references: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009 Sep-Oct;1(5):475-91
references: 20049812
references: NMR Biomed. 2007 Feb;20(1):21-7
references: 16998951
references: Am J Physiol. 1989 Oct;257(4 Pt 1):L163-73
references: 2572174
references: Chem Commun (Camb). 2010 Mar 28;46(12):2082-4
references: 20221499
references: IEEE Trans Nanobioscience. 2007 Dec;6(4):298-308
references: 18217623
references: J Am Chem Soc. 2005 Apr 13;127(14):4990-1
references: 15810812
references: J Control Release. 2000 Oct 3;69(1):1-25
references: 11018543
references: Nat Rev Cancer. 2002 Jan;2(1):11-8
references: 11902581
references: Magn Reson Med. 2010 May;63(5):1383-90
references: 20432309
references: Biochim Biophys Acta. 1994 Jul 13;1193(1):212-8
references: 7518693
references: Nat Biotechnol. 2001 Apr;19(4):316-7
references: 11283581
references: J Colloid Interface Sci. 2009 May 15;333(2):690-8
references: 19215940
references: Langmuir. 2008 May 20;24(10):5270-6
references: 18412382
references: Nat Med. 2003 Jan;9(1):123-8
references: 12514725