title: [Relationship of glucose metabolic rate and plasma levels of adiponectin and leptin in patients with metabolic syndrome].
abstract: OBJECTIVE
  To investigate the relationship of glucose metabolic rate (GMR) and plasma levels of adiponectin and leptin in patients with metabolic syndrome (MS).
  
  
  METHODS
  A total of 30 MS subjects aged 36-60 years old were selected as MS group. And 20 normal adults were selected as control group. The GMR was evaluated by the technique of hyperinsulinemic euglycemia clamp. The plasma concentrations of adiponectin and leptin were detected by enzyme-linked immunosorbent assay (ELISA). Blood pressure, waist circumference (WC), body weight and body height were measured.
  
  
  RESULTS
  (1) During the steady state (last 30 min), the GMR was significantly lower in MS group than that in control Group [(4.13 ± 1.34) mg×kg(-1)×min(-1) vs (8.33 ± 1.59) mg·kg(-1)×min(-1), P < 0.01]. (2) The plasma level of adiponectin was significantly lower in MS group than that in control group [(5.15 ± 2.54) µg/ml vs (10.28 ± 5.50) µg/ml, P < 0.01]. The plasma level of leptin were significantly higher in MS group than that in control group [(189.37 ± 90.48) ng/ml vs (126.55 ± 72.70) ng/ml, P < 0.01]. (3) In MS group, glucose metabolic rate was associated with WC, BMI, TG, HDL-C FINS, leptin, and adiponectin, (all P < 0.05).
  
  
  CONCLUSIONS
  The technique of hyperinsulinemic euglycemic clamp shows that the BMR of MS patients significantly decreases. It may be associated with their lowered plasma levels of adiponectin and leptin.
authors: Department of Endocrinology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou Traditional Chinese Medicine University, Foshan 528000, China. yejianhong2005@163.com
authors: Jian-hong
authors: JH
authors: Ye
authors: Xiao-chun
authors: XC
authors: Shu
authors: Ping
authors: P
authors: Chen
authors: Wei-hua
authors: WH
authors: Mai
authors: Jiang-ming
authors: JM
authors: Lang