title: Total synthesis and bioactivity of 18(R)-hydroxyeicosapentaenoic acid.
abstract: Resolvins are family of lipid mediators derived from omega-3 polyunsaturated fatty acids, which are generated during the resolution phase of acute inflammation. Resolvin E1 is biosynthesized from eicosapentaenoic acid via 18(R)-hydroxyeicosapentaenoic acid (18R-HEPE) in the Cox-2 and lipoxygenase mediated pathway and has proven to exhibit potent anti-inflammatory activity. We report herein the first total chemical synthesis of 18R-HEPE and demonstrate that this compound displays in vivo bioactivity by blocking neutrophil infiltration in a murine model of zymosan-induced peritonitis.
authors: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States.
authors: Venkata R
authors: VR
authors: Krishnamurthy
authors: Ann
authors: A
authors: Dougherty
authors: Carolyn A
authors: CA
authors: Haller
authors: Elliot L
authors: EL
authors: Chaikof
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