title: Expression of CD26 and its association with dipeptidyl peptidase IV activity in lymphocytes of type 2 diabetes patients.
abstract: Immune response and inflammation were suggested to play certain roles in the development and complications of type 2 diabetes mellitus. The main objective of this study was to investigate the CD26 expression and its relationship with adenosine deaminase (ADA), dipeptidyl peptidase IV (DPP-IV), γ-glutamyltransferase (GGT), and N-acetyl-β-glucosaminidase (NAG) activities in lymphocytes of type 2 diabetics (T2DM) patients. These parameters were assessed in 25 T2DM patients and 20 control subjects. We observed a decrease in CD26 expression and a significant increase in the ADA activity in T2DM patients when compared with control subjects. There were no differences between activities of DPP-IV, NAG, and GGT in lymphocytes of T2DM patients and control subjects. Meanwhile, a significant negative correlation was observed between CD26 expression and DPP-IV activity in lymphocytes of T2DM patients. Moreover, a positive correlation was found between DPPIV and ADA activities. The results suggest that the reduction of CD26 expression may be associated in the regulation of DPP-IV in T2DM patients.
authors: Postgraduate Program in Pharmacology, Health Science Centre, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.
authors: Luziane Potrich
authors: LP
authors: Bellé
authors: Paula Eliete Rodrigues
authors: PE
authors: Bitencourt
authors: Karine Santos
authors: KS
authors: de Bona
authors: Régis Adriel
authors: RA
authors: Zanette
authors: Rafael Noal
authors: RN
authors: Moresco
authors: Maria Beatriz
authors: MB
authors: Moretto