title: The yin, the yang, and the angiopoietin-1.
abstract: Twenty years after the discovery of the vascular endothelial Tie receptor tyrosine kinases and 15 years after the discovery of the Tie2 ligand, angiopoietin-1 (Angpt1, also known as Ang1), a study published in the current issue of the JCI reveals an unexpected loss-of-function phenotype of mice conditionally deleted of the Angpt1 gene. The results suggest that Angpt1 is needed as a vascular stabilizing factor that organizes and limits the angiogenesis response and protects from pathological consequences, such as tissue fibrosis.
authors: Molecular/Cancer Biology Program and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
authors: Pipsa
authors: P
authors: Saharinen
authors: Kari
authors: K
authors: Alitalo
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