title: Essential role for p53 and caspase-9 in DNA damaging drug-induced apoptosis in neuroblastoma IMR32 cells.
abstract: Neuroblastoma is a solid tumor of the sympathetic nervous system accounting for up to 10% of pediatric cancers and 15% of cancer-related deaths. It is a useful system for investigation of stress signal-mediated apoptosis as a tumor suppression mechanism. In this study, we present evidence that p53 mediates DNA damaging drug-induced apoptosis in IMR32 cells through the caspase-9 pathway. In summary, we define a molecular pathway for mediating DNA damaging drug-induced apoptosis in human neuroblastoma IMR32 cells and suggest that inactivation of essential components of this apoptotic pathway may confer drug resistance on neuroblastoma cells.
authors: The Institute of Sericulture and Systems Biology, College of Biotechnology, Southwest University, Chongqing, China.
authors: Tai
authors: T
authors: Li
authors: Zhao-Bo
authors: ZB
authors: Cui
authors: Xiao-Xue
authors: XX
authors: Ke
authors: Juan
authors: J
authors: Tan
authors: Fang-Fang
authors: FF
authors: Li
authors: Ting
authors: T
authors: Li
authors: Xiang-Wei
authors: XW
authors: Wang
authors: Hong-Juan
authors: HJ
authors: Cui