title: None of the known different fibroblast growth-factor receptor-2 carboxy-terminal tails are restricted to cancer-cells.
abstract: Fibroblast growth factor receptor-2 cDNAs derived from healthy tissues code for proteins with a 63 amino acid carboxy-terminal tail. Some cDNAs isolated from human tumour cDNA libraries code for receptors with 11, 15 or 29 amino acid carboxy-terminal tails. However, the important issue as to whether these latter tails are tumour specific markers has remained unresolved. We show that mRNAs coding for FGFR-2 proteins with carboxy-terminal tails of 11, 29 and 63 amino acids are co-expressed not only in many tumour tissues but also in normal human tissues, while the 15 amino acid tail appears to reflect a cloning artefact.
authors: CHR NANTES,INST BIOL,INSERM,U211,F-44035 NANTES,FRANCE. CTR LUTTE CONTRE CANC PAUL STRAUSS,F-67085 STRASBOURG,FRANCE.
authors: E
authors: E
authors: Gilbert
authors: D
authors: D
authors: Muller
authors: R
authors: R
authors: Breathnach