title: HER-2 positive and p53 negative breast cancers are associated with poor prognosis.
abstract: p53 and HER-2 coexpression in breast cancer has been controversial. These markers were tested using immunohistochemistry and HercepTest. HER-2 expression is related to reduced breast cancer survival (p = .02) . p53 expression relates to HER-2 expression (p = .029). Coexpression between p53 and HER-2 has no relation to prognosis. On univariate and multivariate analysis, combination of HER-2 positive and p53 negative expression was associated with a poor prognosis (p = .018 and p = .027, respectively), while the combination of HER-2 negative and p53 positive expression was associated with a favorable prognosis (p = .022 and p = .010, respectively). Therefore the expression of these markers should be considered collectively.
authors: Department of Surgery, Beaumont Hospital, Dublin, Ireland. dalazawi@rcsi.ie
authors: Dhafir
authors: D
authors: Al-azawi
authors: Sum
authors: S
authors: Leong
authors: Limy
authors: L
authors: Wong
authors: Elaine
authors: E
authors: Kay
authors: Arnold D K
authors: AD
authors: Hill
authors: Leonie
authors: L
authors: Young