title: Organocatalytic asymmetric synthesis of sulfoxides from sulfenic acid anions mediated by a Cinchona-derived phase-transfer reagent.
abstract: Preliminary results concerning a conceptually novel route to chiral sulfoxides based on the asymmetric alkylation of sulfenate salts with alkyl halides mediated by a chiral phase-transfer catalyst are described. As a representative example, o-anisyl methyl sulfoxide was produced in 96% yield and with an enantiomeric excess of 58% using commercial cinchonidinium derivative 2a.
authors: Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, INC3M, FR 3038, ENSICAEN & Université de Caen Basse-Normandie, 14050 CAEN, France.
authors: Fabien
authors: F
authors: Gelat
authors: Jayadevan
authors: J
authors: Jayashankaran
authors: Jean-François
authors: JF
authors: Lohier
authors: Annie-Claude
authors: AC
authors: Gaumont
authors: Stéphane
authors: S
authors: Perrio