title: rac-Ethyl 4-hy-droxy-6-(2-hy-droxy-phen-yl)-2-oxo-4-(trifluoro-methyl)per-hydro-pyrimidine-5-carboxyl-ate.
abstract: In the title compound, C(14)H(15)F(3)N(2)O(5), prepared by reaction of 2-hy-droxy-benzaldehyde, ethyl 4,4,4-trifluoro-3-oxobutano-ate and urea, the tetra-pyrimidine ring adopts a half-chair conformation. The crystal structure is stabilized by five inter-molecular hydrogen bonds, three O-H⋯O and two N-H⋯O, giving cyclic dimers (through three hydrogen bonds) which are further extended into a two-dimensional network.
authors: College of Chemistry and Chemical Engineering, Xuchang University, Xuchang, Henan Province 461000, People's Republic of China.
authors: Xiao-Ping
authors: XP
authors: Song
authors: Gong-Chun
authors: GC
authors: Li
authors: Feng-Xiang
authors: FX
authors: Zhu
authors: Chang-Zeng
authors: CZ
authors: Wu
references: Biochemistry. 2004 Oct 19;43(41):13072-82
references: 15476401
references: J Biol Chem. 2005 Apr 1;280(13):12658-67
references: 15665380
references: Bioorg Med Chem. 2006 Dec 15;14(24):8582-9
references: 16971126
references: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references: 18156677