title: Difference in histological activity of non-tumorous liver tissue between hepatitis B virus- and hepatitis C virus-associated hepatocellular carcinoma without cirrhosis.
abstract: To elucidate the difference in the liver carcinogenetic process during hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, non-tumorous liver tissues obtained from 10 patients who developed HBV-associated hepatocellular carcinoma (HCC) without cirrhosis were compared with those obtained from 26 patients who developed HCV-associated HCC without cirrhosis. The extent of fibrosis was similar in both groups. In contrast, necroinflammatory activities were significantly higher in patients with HCV than in patients with HBV. These results indicate that ongoing liver inflammation mediates the hepatocarcinogenesis more pronouncedly in HCV infection than in HBV infection.
authors: NAGASAKI UNIV, SCH MED, DEPT INTERNAL MED 1, NAGASAKI 852, JAPAN. NAGASAKI UNIV, HLTH RES CTR, NAGASAKI 852, JAPAN. NAGASAKI UNIV, INST TROP MED, DEPT PATHOL, NAGASAKI 852, JAPAN.
authors: T
authors: T
authors: Muro
authors: K
authors: K
authors: Nakata
authors: H
authors: H
authors: Kamito
authors: Y
authors: Y
authors: Kato
authors: K
authors: K
authors: Nakao
authors: K
authors: K
authors: Toriyama
authors: S
authors: S
authors: Tsuruta
authors: Y
authors: Y
authors: Shibata
authors: T
authors: T
authors: Arima
authors: S
authors: S
authors: Nagataki