title: The epigenetics of estrogen: epigenetic regulation of hormone-induced memory enhancement.
abstract: Epigenetic processes have been implicated in everything from cell proliferation to maternal behavior. Epigenetic alterations, including histone alterations and DNA methylation, have also been shown to play critical roles in the formation of some types of memory, and in the modulatory effects that factors, such as stress, drugs of abuse and environmental stimulation, have on the brain and memory function. Recently, we demonstrated that the ability of the sex-steroid hormone 17β-estradiol (E(2)) to enhance memory formation is dependent on histone acetylation and DNA methylation, a finding that has important implications for understanding how hormones influence cognition in adulthood and aging. In this article, we provide an overview of the literature demonstrating that epigenetic processes and E(2) influence memory, describe our findings indicating that epigenetic alterations regulate E(2)-induced memory enhancement, and discuss directions for future work on the epigenetics of estrogen.
authors: Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. frickk@uwm.edu
authors: Karyn M
authors: KM
authors: Frick
authors: Zaorui
authors: Z
authors: Zhao
authors: Lu
authors: L
authors: Fan
references: Nature. 2007 May 10;447(7141):178-82
references: 17468743
references: Neurobiol Learn Mem. 2007 Nov;88(4):393-408
references: 17869132
references: J Neuroendocrinol. 2006 Oct;18(10):787-95
references: 16965297
references: Annu Rev Psychol. 1997;48:547-72
references: 9046568
references: Mol Endocrinol. 2003 May;17(5):831-44
references: 12554763
references: Endocrinology. 2003 Jul;144(7):2836-44
references: 12810538
references: Brain Res Rev. 2008 Mar;57(2):363-75
references: 17822775
references: Neurobiol Learn Mem. 2008 May;89(4):599-603
references: 17881251
references: J Neurosci. 2006 Sep 13;26(37):9439-47
references: 16971528
references: Annu Rev Pharmacol Toxicol. 2002;42:135-63
references: 11807168
references: Biol Psychiatry. 2009 Feb 1;65(3):191-7
references: 19006788
references: Ann N Y Acad Sci. 2011 Jan;1216:99-113
references: 21272014
references: Psychoneuroendocrinology. 2004 Aug;29(7):883-90
references: 15177703
references: Neuron. 2004 Jun 24;42(6):947-59
references: 15207239
references: Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5605-10
references: 20212170
references: Neurobiol Learn Mem. 2011 Jul;96(1):2-12
references: 21195202
references: Biochim Biophys Acta. 2010 Oct;1800(10):1045-55
references: 19913600
references: Endocrinology. 2003 Mar;144(3):832-8
references: 12586759
references: Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20912-7
references: 19934035
references: JAMA. 2002 Jul 17;288(3):321-33
references: 12117397
references: Neuron. 2004 Jun 24;42(6):961-72
references: 15207240
references: J Neurosci. 2010 Mar 10;30(10):3589-99
references: 20219993
references: J Neurosci. 2008 Aug 27;28(35):8660-7
references: 18753366
references: Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):840-53
references: 20833281
references: Learn Mem. 2007 Aug 29;14(9):564-72
references: 17761541
references: J Neurosci. 1992 Jul;12(7):2549-54
references: 1613547
references: Neurosci Lett. 2010 May 21;475(3):179-83
references: 20371377
references: Front Neuroendocrinol. 2008 May;29(2):219-37
references: 18078984
references: Neurobiol Learn Mem. 2007 Sep;88(2):208-16
references: 17507257
references: J Neurophysiol. 1999 Feb;81(2):925-9
references: 10036289
references: Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9447-52
references: 19470462
references: J Biol Chem. 2004 Sep 24;279(39):40545-59
references: 15273246
references: J Neurosci. 1999 Jul 15;19(14):5792-801
references: 10407020
references: Neuroscience. 2009 Sep 29;163(1):1-8
references: 19531374
references: Neuropsychopharmacology. 2009 Jun;34(7):1721-32
references: 19145227
references: Learn Mem. 2011 Jan 11;18(2):71-9
references: 21224411
references: Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):865-70
references: 14694190
references: Neurobiol Aging. 2002 Jan-Feb;23(1):87-95
references: 11755023
references: Learn Mem. 2002 Mar-Apr;9(2):58-65
references: 11992016
references: Rev Neurosci. 2005;16(2):87-121
references: 15957576
references: J Neurosci. 2007 Jun 6;27(23):6128-40
references: 17553985
references: Nature. 2009 May 7;459(7243):55-60
references: 19424149
references: Neuropsychopharmacology. 2010 Mar;35(4):870-80
references: 20010553
references: Psychol Rev. 1992 Apr;99(2):195-231
references: 1594723
references: Learn Mem. 2005 Mar-Apr;12(2):111-9
references: 15805310
references: J Neurosci. 2011 Jan 12;31(2):764-74
references: 21228185
references: Neuron. 2007 Mar 15;53(6):857-69
references: 17359920
references: J Neurosci. 2010 Mar 24;30(12):4390-400
references: 20335475
references: J Biol Chem. 2006 Jun 9;281(23):15763-73
references: 16606618
references: Pharmacol Biochem Behav. 2006 May;84(1):112-9
references: 16759685
references: Curr Opin Neurobiol. 2009 Jun;19(3):336-42
references: 19539459
references: Neurobiol Learn Mem. 2006 Jul;86(1):35-46
references: 16529958
references: Nat Neurosci. 2006 Apr;9(4):519-25
references: 16501568
references: J Neurosci. 2000 Dec 1;20(23):8853-60
references: 11102494
references: Prog Brain Res. 2007;163:741-53
references: 17765748
references: Learn Mem. 2006 May-Jun;13(3):322-8
references: 16741283
references: Behav Neurosci. 2008 Jun;122(3):716-21
references: 18513142
references: Neuropsychopharmacology. 2008 Jun;33(7):1584-602
references: 17805310
references: Neuroscience. 2008 Sep 9;155(4):1106-19
references: 18601981
references: J Neurosci. 2004 Jun 30;24(26):5913-21
references: 15229239
references: Annu Rev Pharmacol Toxicol. 2007;47:657-80
references: 16918306