title: Acute promyelocytic leukemia with complex translocation t(5;17;15)(q35;q21;q22): case report and review of the literature.
abstract: The t(15;17)(q22;q21), resulting in PML-RARA fusion gene, is a characteristic chromosomal translocation in acute promyelocytic leukemia (APL). We report a pediatric APL case with a 3-way translocation: t(5;17;15)(q35;q21;q22). Complete blood cell counts of a 12-year-old girl, of pale appearance, showed pancytopenia with increased blasts. Morphology and immunophenotype of the leukemic cells were compatible with APL. Karyotype analysis showed t(5;17;15)(q35;q21;q22) and add(7)(q32). We detected the PML-RARA fusion gene by both reverse transcriptase-polymerase chain reaction and fluorescent in situ hybridization analysis. The patient underwent successful treatment with cytarabine with all-trans retinoic acid and anthracycline-based therapy.
authors: Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.
authors: Sung Ran
authors: SR
authors: Cho
authors: Seo-Jin
authors: SJ
authors: Park
authors: Hyon J
authors: HJ
authors: Kim
authors: Il Joong
authors: IJ
authors: Park
authors: Jong Rak
authors: JR
authors: Choi
authors: Hyun Joo
authors: HJ
authors: Jung
authors: Jun Eun
authors: JE
authors: Park