title: Fluorinated paramagnetic chelates as potential multi-chromic 19F tracer agents.
abstract: A class of potential multi-chromic (19)F imaging tracers is made by pairing metal ions with a fluorinated chelator. All fluorinated metal chelates emit a single (19)F signal. Paramagnetic metal ions shifted the (19)F signal frequency and made the (19)F relaxation rates insensitive toward local chemical environment.
authors: Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, USA.
authors: Zhong-Xing
authors: ZX
authors: Jiang
authors: Yue
authors: Y
authors: Feng
authors: Yihua Bruce
authors: YB
authors: Yu
references: J Am Chem Soc. 2010 Apr 21;132(15):5336-7
references: 20345132
references: Magn Reson Med. 2008 Nov;60(5):1066-72
references: 18956457
references: Invest Radiol. 1989 Mar;24(3):224-7
references: 2753638
references: J Am Chem Soc. 2008 Jan 23;130(3):794-5
references: 18154336
references: Drug Discov Today. 2008 Jun;13(11-12):473-80
references: 18549972
references: Magn Reson Med. 2008 Dec;60(6):1506-11
references: 19025893
references: Chem Commun (Camb). 2009 Oct 28;(40):6044-6
references: 19809638
references: Chemistry. 2010 Jan 4;16(1):134-48
references: 19957317
references: Chem Commun (Camb). 2008 Jun 14;(22):2514-6
references: 18506228
references: Nature. 1971 Jul 23;232(5308):236-45
references: 4937076
references: Angew Chem Int Ed Engl. 2009;48(26):4755-8
references: 19475598
references: Synthesis (Stuttg). 2008 Jan 1;2008(2):215-220
references: 20585414
references: FASEB J. 2007 Jun;21(8):1647-54
references: 17284484
references: J Magn Reson Imaging. 1994 Jul-Aug;4(4):609-13
references: 7949689
references: J Am Chem Soc. 2008 Mar 5;130(9):2832-41
references: 18266363
references: Nat Neurosci. 2005 Apr;8(4):527-33
references: 15768036