title: Tick-borne encephalitis in Latvia 1973-2009: epidemiology, clinical features and sequelae.
abstract: OBJECTIVE
  To report a 37-year observational experience in Latvia relating the incidence of human tick-borne encephalitis (TBE) and its clinical manifestations, to the field abundance of ticks.
  
  
  METHODS
  Tick abundance was measured by standard flagging techniques. Incidence of human tick-borne disease was derived from Public Health reporting data. Clinical and follow-up data were determined from hospital cohorts from 1973 to 2009.
  
  
  RESULTS
  Two TBE incidence peaks in the mid-1970s and the 1990s correlated with increased field abundance of ticks. Increased human TBE in the 1970s was associated with higher field abundance of both Ixodes ricinis and I. Persulcatus. The 1990s peak was particularly associated with I. ricinus, the species predominating in western/central Latvia, and with other factors, including changed agricultural land usage. Proportions of patients with meningitic or focal forms of TBE were similar in the two outbreaks and the intervening periods. Meningeal irritation occurred in 90%, altered consciousness in 19%, ataxia in 34%, seizures in 9%, bulbar features in 2-3% and limb weakness in 15% with shoulder amyotrophy predominating in 5%. Annual mortality varied from 0 to 1.3% and was not related to the overall incidence of TBE. Follow-up for 1-13 years of a cohort of 100 patients revealed long-term sequelae in over 50%, more commonly in those suffering focal forms of acute TBE.
  
  
  CONCLUSIONS
  Clinical features and mortality of the 1970s and 1990s TBE outbreaks were similar and did not point to a change in virulence.
authors: Riga Stradins University, Riga, Latvia.
authors: G
authors: G
authors: Karelis
authors: A
authors: A
authors: Bormane
authors: I
authors: I
authors: Logina
authors: I
authors: I
authors: Lucenko
authors: N
authors: N
authors: Suna
authors: A
authors: A
authors: Krumina
authors: M
authors: M
authors: Donaghy