title: Vascular endothelial growth factor expression correlates with hematogenous metastasis and prognosis in colorectal carcinoma.
abstract: We investigated the expression of vascular endothelial growth factor (VEGF) in 175 colorectal carcinomas by immunohistochemistry. VEGF expression was correlated with advanced TNM stage (III, IV), advanced T stage (T3, T4), vessel involvement, lymph node metastasis, and liver metastasis. With regard to the prognosis, both overall and relapse-free survival was significantly poorer, and furthermore, the hematogenous recurrences were significantly more commonly found in the patients with VEGF-positive tumors. VEGF expresion in colorectal carcinomas may have a substantial value in predicting those patients at high risk for hematogenous recurrence after surgery.
authors: S
authors: S
authors: Kang
authors: K
authors: K
authors: Maeda
authors: Y
authors: Y
authors: Chung
authors: N
authors: N
authors: Onoda
authors: Y
authors: Y
authors: Ogawa
authors: S
authors: S
authors: Takatsuka
authors: M
authors: M
authors: Ogawa
authors: T
authors: T
authors: Sawada
authors: B
authors: B
authors: Nakata
authors: Y
authors: Y
authors: Nishiguchi
authors: T
authors: T
authors: Ikehara
authors: M
authors: M
authors: Okuno
authors: M
authors: M
authors: Sowa