title: The Ehrlich ascites carcinoma (EAC) contains 300-500 Da inhibitor(s) suppressing DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice.
abstract: A protein preparation obtained from the Ehrlich ascites carcinoma (EAC) by acetone precipitation, water extraction and subsequent two-step alcohol fractionation reduced significantly EAC cell proliferation in vivo and in vitro. The preparation was found to contain a low molecular-weight growth-inhibitory activity, suppressing both DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice. The approximate molecular weight of this inhibitory component(s) is about 300-500 Da, corresponding to oligopeptide molecule(s).
authors: RUSSIAN STATE MED UNIV, FAC MED BIOL, DEPT MED BIOL, MOSCOW 117513, RUSSIA. RUSSIAN STATE MED UNIV, LAB DRUG ECOL TOXICOL & METAB, MOSCOW 117513, RUSSIA.
authors: D
authors: D
authors: Gembitsky
authors: N
authors: N
authors: Popova
authors: A
authors: A
authors: Antokhin
authors: Y
authors: Y
authors: Podusov
authors: L
authors: L
authors: Karpets
authors: N
authors: N
authors: Adrianov
authors: Y
authors: Y
authors: Romanov