title: Progesterone receptor polymorphisms and clinical response to 17-alpha-hydroxyprogesterone caproate.
abstract: OBJECTIVE
  Seventeen-alpha-hydroxyprogesterone caproate (17-OHPC) reduces recurrent preterm birth (PTB). We hypothesized that single nucleotide polymorphisms in the human progesterone receptor (PGR) affect response to 17-OHPC in the prevention of recurrent PTB.
  
  
  METHODS
  We conducted secondary analysis of a study of 17-OHPC vs placebo for recurrent PTB prevention. Twenty PGR gene single nucleotide polymorphisms were studied. Multivariable logistic regression assessed for an interaction between PGR genotype and treatment status in modulating the risk of recurrent PTB.
  
  
  RESULTS
  A total of 380 women were included; 253 (66.6%) received 17-OHPC and 127 (33.4%) received placebo. In all, 61.1% of women were African American. Multivariable logistic regression demonstrated significant treatment-genotype interactions (either a beneficial or harmful treatment response) for African Americans delivering<37 weeks' gestation for rs471767 and rs578029, and for Hispanics/Caucasians delivering<37 weeks' gestation for rs500760 and <32 weeks' gestation for rs578029, rs503362, and rs666553.
  
  
  CONCLUSIONS
  The clinical efficacy and safety of 17-OHPC for recurrent PTB prevention may be altered by PGR gene polymorphisms.
authors: Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network, Bethesda, MD, USA. tracy.manuck@hsc.utah.edu
authors: Tracy A
authors: TA
authors: Manuck
authors: Yinglei
authors: Y
authors: Lai
authors: Paul J
authors: PJ
authors: Meis
authors: Mitchell P
authors: MP
authors: Dombrowski
authors: Baha
authors: B
authors: Sibai
authors: Catherine Y
authors: CY
authors: Spong
authors: Dwight J
authors: DJ
authors: Rouse
authors: Celeste P
authors: CP
authors: Durnwald
authors: Steve N
authors: SN
authors: Caritis
authors: Ronald J
authors: RJ
authors: Wapner
authors: Brian M
authors: BM
authors: Mercer
authors: Susan M
authors: SM
authors: Ramin
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