title: Prognostic value of urokinase-type plasminogen activators in gastric-cancer.
abstract: To elucidate the relation between urokinase-type plasminogen activator (U-PA) and metastasis in gastric cancer, we examined U-PA tissue status immunohistochemically. Ninety-eight primary gastric cancer, prepared by AMeX method, were analyzed with anti-U-PA and anti-proliferating cell nuclear antigen (PCNA) monoclonal antibody. In addition, DNA ploidy patterns were determined by cytofluorometer after staining with propidium iodide. U-PA immunoreactivity can be observed as diffuse cytoplasmic staining, as intensely outlined luminal borders or in desquameted cells in the lumens. U-PA expression-positive tumors showed higher incidence of serosal invasion, lymph node involvement or larger tumors than did U-PA negative ones. There was no correlation between U-PA tissue status and PCNA labeling rates or DNA ploidy patterns. Patients with a U-PA positive tumor survived significantly shorter than those with U-PA negative ones. These results may indicate that U-PA tissue status is a useful biological prognostic indicator in gastric cancer. The high malignant potential of U-PA positive tumors may be associated with a rapid infiltrating capacity through gastric wall but not with a high proliferative activity.
authors: KANAZAWA UNIV,CANC RES INST,DEPT EXPTL THERAPEUT,KANAZAWA,ISHIKAWA 920,JAPAN.
authors: Y
authors: Y
authors: Yonemura
authors: I
authors: I
authors: Ninomiya
authors: N
authors: N
authors: Nojima
authors: K
authors: K
authors: Sugiyama
authors: T
authors: T
authors: Fujimura
authors: K
authors: K
authors: Tsuchihara
authors: T
authors: T
authors: Kawamura
authors: M
authors: M
authors: Kaji
authors: I
authors: I
authors: Miyazaki
authors: Y
authors: Y
authors: Endo
authors: M
authors: M
authors: Tanaka
authors: T
authors: T
authors: Sasaki