title: Intracellular α(2C)-adrenoceptors: storage depot, stunted development or signaling domain?
abstract: G-protein coupled receptors (GPCRs) are generally considered to function as cell surface signaling structures that respond to extracellular mediators, many of which do not readily access the cell's interior. Indeed, most GPCRs are preferentially targeted to the plasma membrane. However, some receptors, including α(2C)-Adrenoceptors, challenge conventional concepts of GPCR activity by being preferentially retained and localized within intracellular organelles. This review will address the issues associated with this unusual GPCR localization and discuss whether it represents a novel sub-cellular niche for GPCR signaling, whether these receptors are being stored for rapid deployment to the cell surface, or whether they represent immature or incomplete receptor systems.
authors: Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
authors: Maqsood A
authors: MA
authors: Chotani
authors: Nicholas A
authors: NA
authors: Flavahan
references: Neuroendocrinology. 1995 Sep;62(3):215-25
references: 8538858
references: Biochemistry. 2006 Apr 18;45(15):4760-7
references: 16605244
references: Neuropharmacology. 2006 Sep;51(3):397-413
references: 16750543
references: Nature. 1999 Nov 11;402(6758):181-4
references: 10647009
references: Nat Rev Neurosci. 2005 Aug;6(8):615-25
references: 16062170
references: Pharmacol Rev. 2001 Jun;53(2):319-56
references: 11356987
references: Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12195-200
references: 19587238
references: J Biol Chem. 1995 Mar 10;270(10):4967-70
references: 7890600
references: Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1700-5
references: 17172270
references: Mol Pharmacol. 1999 Jul;56(1):154-61
references: 10385696
references: J Cell Biol. 1993 Jul;122(1):39-51
references: 8314846
references: Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H243-50
references: 15764673
references: BioDrugs. 2007;21(3):157-66
references: 17516711
references: Biochem Biophys Res Commun. 1993 May 28;193(1):318-23
references: 8099284
references: N Engl J Med. 2002 Oct 10;347(15):1135-42
references: 12374873
references: Am J Physiol. 1998 Mar;274(3):C654-62
references: 9530096
references: J Neurosci. 2008 Apr 23;28(17):4336-49
references: 18434512
references: J Cell Biol. 1995 Jul;130(2):285-97
references: 7615632
references: Circulation. 1995 Sep 15;92(6):1448-51
references: 7664425
references: J Biol Chem. 2000 Jul 28;275(30):23059-64
references: 10801795
references: J Pharmacol Exp Ther. 2005 Apr;313(1):16-23
references: 15615865
references: J Pharmacol Exp Ther. 2009 Jan;328(1):223-30
references: 18955588
references: Proc Natl Acad Sci U S A. 1992 May 15;89(10):4319-23
references: 1584766
references: J Pharmacol Exp Ther. 1986 Jul;238(1):131-8
references: 3014111
references: Circulation. 2002 Nov 5;106(19):2491-6
references: 12417548
references: Rheum Dis Clin North Am. 1996 Nov;22(4):765-81
references: 8923595
references: Curr Opin Neurobiol. 2002 Jun;12(3):287-92
references: 12049935
references: Traffic. 2008 Nov;9(11):1878-93
references: 18764821
references: J Comp Neurol. 1996 Aug 12;372(1):135-65
references: 8841925
references: Circ Res. 2004 May 28;94(10):1367-74
references: 15087420
references: Arch Int Pharmacodyn Ther. 1990 Nov-Dec;308:63-75
references: 1983065
references: J Pharmacol Exp Ther. 1984 Sep;230(3):699-705
references: 6088763
references: Annu Rev Pharmacol Toxicol. 2004;44:559-609
references: 14744258
references: Br J Pharmacol. 1991 Jan;102(1):10-2
references: 1646053
references: J Neurosci. 2003 Mar 15;23(6):2075-85
references: 12657666
references: J Pharmacol Exp Ther. 2006 Sep;318(3):974-81
references: 16757535
references: Br J Pharmacol. 1989 Jun;97(2):563-71
references: 2547477
references: Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H69-76
references: 15345481
references: Nature. 1992 Aug 27;358(6389):761-4
references: 1380673
references: Pharmacol Rev. 2005 Sep;57(3):289-98
references: 16109836
references: Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13020-5
references: 15319474
references: J Biol Chem. 2010 Dec 31;285(53):41772-80
references: 21041313
references: Kurume Med J. 1990;37 Suppl:S95-9
references: 2166182
references: Hepatology. 2009 Apr;49(4):1218-27
references: 19185004
references: Biochim Biophys Acta. 2011 Feb;1813(2):346-57
references: 21145921
references: J Biol Chem. 1992 Dec 15;267(35):25473-9
references: 1334095
references: Am J Physiol. 1997 Dec;273(6):H2756-64
references: 9435612
references: Trends Pharmacol Sci. 1997 Jun;18(6):211-9
references: 9227000
references: Mol Pharmacol. 1997 May;51(5):711-20
references: 9145909
references: Cell. 2006 Nov 17;127(4):803-15
references: 17110338
references: Can J Physiol Pharmacol. 2006 Mar-Apr;84(3-4):287-97
references: 16902576
references: Mol Pharmacol. 2001 May;59(5):1256-68
references: 11306711
references: Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G433-44
references: 19033537
references: J Biol Chem. 2006 Jun 2;281(22):15475-84
references: 16595684
references: Recent Prog Horm Res. 1996;51:319-51; discussion 352-3
references: 8701085
references: Traffic. 2010 Apr;11(4):560-78
references: 20059747
references: Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):487-97
references: 20862454
references: Biochim Biophys Acta. 1999 Dec 6;1473(1):96-107
references: 10580131
references: Mol Pharmacol. 2001 Dec;60(6):1195-200
references: 11723226
references: Mol Biol Cell. 1999 Jan;10(1):35-46
references: 9880325
references: J Neurosci. 1999 Nov 1;19(21):9281-8
references: 10531432
references: J Vasc Surg. 1990 Jul;12(1):45-9
references: 2165189
references: Am J Physiol. 1985 Nov;249(5 Pt 2):H950-5
references: 2865900
references: Science. 1996 Aug 9;273(5276):801-3
references: 8670421
references: J Biol Chem. 1996 Jul 26;271(30):18082-7
references: 8663433
references: J Immunol. 2003 Apr 15;170(8):4196-200
references: 12682252
references: Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H59-67
references: 12946937
references: J Biol Chem. 1994 Apr 1;269(13):10093-9
references: 7908287
references: Mol Pharmacol. 2006 Jan;69(1):45-55
references: 16195468
references: J Biol Chem. 2006 Nov 10;281(45):34561-73
references: 16959776
references: Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):9982-7
references: 17535904
references: Rheum Dis Clin North Am. 2003 May;29(2):275-91, vi
references: 12841295
references: FASEB J. 2008 Sep;22(9):3255-63
references: 18556464
references: Neuron. 2000 Apr;26(1):155-67
references: 10798400
references: J Pharmacol Exp Ther. 2005 Apr;313(1):432-9
references: 15608085
references: Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H266-72
references: 18487435
references: Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9950-5
references: 9275232
references: Biochem J. 1997 Dec 1;328 ( Pt 2):431-8
references: 9371698
references: Am J Physiol. 1991 Apr;260(4 Pt 2):H1166-71
references: 1849370
references: Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1075-83
references: 10749700
references: Exp Cell Res. 2009 Mar 10;315(5):877-89
references: 19162007
references: Science. 1996 Aug 9;273(5276):803-5
references: 8670422
references: Cell Stress Chaperones. 1996 Jun;1(2):117-25
references: 9222597
references: J Biol Chem. 1996 Mar 1;271(9):5017-24
references: 8617778
references: Glycobiology. 1994 Dec;4(6):917-28
references: 7734854
references: Life Sci. 2001 Apr 6;68(19-20):2277-85
references: 11358337
references: J Biol Chem. 1994 Nov 4;269(44):27719-26
references: 7961693
references: Proc Natl Acad Sci U S A. 1988 Sep;85(17):6301-5
references: 2842764
references: J Biol Chem. 2000 Nov 10;275(45):35424-31
references: 10906149
references: Br J Pharmacol. 2007 Sep;152(1):91-100
references: 17618305
references: Am J Physiol. 1988 Jul;255(1 Pt 2):H121-30
references: 2839993
references: Am J Physiol. 1988 Nov;255(5 Pt 2):H1000-3
references: 2903677
references: J Virol. 2000 Jul;74(14):6600-13
references: 10864674
references: Cell Signal. 2006 Mar;18(3):318-27
references: 15961277
references: Trends Pharmacol Sci. 2010 May;31(5):221-8
references: 20303186
references: Peptides. 2010 Nov;31(11):2035-45
references: 20691743
references: Cell Signal. 2007 Mar;19(3):481-9
references: 16979872
references: Exp Cell Res. 2001 May 1;265(2):288-93
references: 11302694
references: Cell. 2002 Nov 15;111(4):577-88
references: 12437930