title: Identification of common mechanisms between endometriosis and ovarian cancer.
abstract: OBJECTIVE
  To determine common molecular markers between endometriosis and ovarian cancer.
  
  
  METHODS
  Patients included women who underwent laparoscopic excision of ovarian endometriotic lesions (n = 7), healthy non-pregnant women with normal pelvises, who underwent excision of normal peritoneum (n = 7). Two epithelial ovarian cancer (EOC) cell lines were also utilized. Expression of transforming growth factor (TGF)-β1, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF), estrogen receptor (ER)-1α, progesterone receptor (PR), androgen receptor (AR), and aromatase was evaluated by real-time RT-PCR.
  
  
  RESULTS
  Endometriosis and EOC cells manifested significantly higher mRNA levels of TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase, while they expressed significantly lower mRNA levels of PR.
  
  
  CONCLUSIONS
  Increased TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase and decreased PR in endometriotic as well as EOC cells suggests a potential association between these two disease processes. This association is important, as it may reveal common mechanisms for both diseases.
authors: Department of Clinical Laboratory, Qianfo Shan Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
authors: Qingsong
authors: Q
authors: Meng
authors: Weixue
authors: W
authors: Sun
authors: John
authors: J
authors: Jiang
authors: Nicole M
authors: NM
authors: Fletcher
authors: Michael P
authors: MP
authors: Diamond
authors: Ghassan M
authors: GM
authors: Saed
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