title: Infections in hemodialysis: a concise review - Part 1: bacteremia and respiratory infections.
abstract: Hemodialysis (HD) patients are particularly predisposed to infections. It seems that the HD procedure per se as well as disturbances in both innate and adaptive immunity significantly contribute to this susceptibility. Infections are the major cause of morbidity and the second cause of death following cardiovascular events in HD patients. Episodes of bacteremia and pneumonia account for the majority of severe infections in this population. In addition to these bacterial infections another common problem in HD units is the blood transmitted viral infections, particularly infections caused by hepatitis B virus, hepatitis C virus and Human immunodeficiency virus. A number of safety concerns exist for limiting the spread of these viral infections among HD patients and the staff of the unit. The aim of the present review is to present in a concise albeit practical form the difficult aspect of infections in HD. For practical reasons the review is separated in two parts. The present first part covers bacteremia and respiratory infections, while the second part will cover blood transmitted viral infections.
authors: Nephrology Department, Medical School, University of Thessaly, Larissa, Greece.
authors: T
authors: T
authors: Eleftheriadis
authors: V
authors: V
authors: Liakopoulos
authors: K
authors: K
authors: Leivaditis
authors: G
authors: G
authors: Antoniadi
authors: I
authors: I
authors: Stefanidis
references: Am J Nephrol. 2008;28(1):152-7
references: 17951997
references: Am J Kidney Dis. 2002 Mar;39(3):549-55
references: 11877574
references: Kidney Int. 2003 Feb;63(2):738-43
references: 12631142
references: Am J Kidney Dis. 1995 Apr;25(4):593-6
references: 7702056
references: JAMA. 1994 Mar 2;271(9):698-702
references: 8309034
references: Am J Nephrol. 2004 Jul-Aug;24(4):402-9
references: 15273446
references: Am J Kidney Dis. 2006 Jul;48 Suppl 1:S248-73
references: 16813991
references: N Engl J Med. 2009 Dec 17;361(25):2493
references: 19923563
references: J Autoimmun. 2003 Aug;21(1):1-9
references: 12892730
references: Perit Dial Int. 2001 Nov-Dec;21(6):554-9
references: 11783763
references: Nephrol Dial Transplant. 2004 May;19(5):1237-44
references: 14993504
references: Chest. 1998 Jan;113(1):25-7
references: 9440563
references: J Am Soc Nephrol. 1994 Mar;4(9):1719-25
references: 8011982
references: JAMA. 1991 May 8;265(18):2364-8
references: 2016833
references: Am J Nephrol. 1989;9(6):454-9
references: 2596535
references: Toxicology. 2006 Feb 1;218(2-3):186-96
references: 16309812
references: MMWR Recomm Rep. 2009 Feb 13;58(RR-3):1-43
references: 19214162
references: Am J Epidemiol. 1975 Dec;102(6):553-63
references: 1202957
references: Ann Intern Med. 1997 Aug 15;127(4):275-80
references: 9265426
references: MMWR Recomm Rep. 2009 Aug 28;58(RR-10):1-8
references: 19713882
references: Nephron. 1996;73(3):421-4
references: 8832601
references: Int J Clin Pract. 2004 Dec;58(12):1115-7
references: 15646407
references: Nephrol Dial Transplant. 2006 Sep;21(9):2556-62
references: 16799169
references: Antimicrob Agents Chemother. 2007 Nov;51(11):3880-6
references: 17724154
references: Am J Kidney Dis. 2004 Nov;44(5):779-91
references: 15492943
references: Toxicol Sci. 2004 Apr;78(2):222-8
references: 14718649
references: Infect Control Hosp Epidemiol. 1995 Sep;16(9):506-11
references: 8537627
references: Am J Kidney Dis. 2009 Jul;54(1):77-85
references: 19339089
references: Scand J Infect Dis. 2007;39(1):6-13
references: 17366006
references: BMJ. 2005 Jul 2;331(7507):10
references: 15994677
references: J Infect Dis. 2009 Aug 1;200(3):321-8
references: 19563262
references: Clin J Am Soc Nephrol. 2008 Sep;3(5):1357-63
references: 18550653
references: Am J Kidney Dis. 1990 Sep;16(3):211-5
references: 2144708
references: N Engl J Med. 2009 Dec 3;361(23):2296-7
references: 19907034
references: Arch Intern Med. 1984 Sep;144(9):1787-9
references: 6476997
references: J Hosp Infect. 1991 Dec;19(4):257-62
references: 1686038
references: MMWR Recomm Rep. 1995 Sep 22;44(RR-12):1-13
references: 7565541
references: MMWR Morb Mortal Wkly Rep. 2007 Mar 9;56(9):197-9
references: 17347644
references: J Am Soc Nephrol. 1999 May;10(5):1045-9
references: 10232691
references: MMWR Recomm Rep. 1996 Apr 26;45(RR-4):1-18
references: 8602127
references: Am J Kidney Dis. 1998 May;31(5):848-52
references: 9590196
references: Am J Kidney Dis. 2008 Feb;51(2):233-41
references: 18215701
references: Vaccine. 2009 Oct 23;27(45):6291-5
references: 19840662
references: Lancet. 1981 Jun 20;1(8234):1373
references: 6113344
references: Vaccine. 2009 Nov 16;27(49):6959-65
references: 19751689
references: N Engl J Med. 2009 Dec 17;361(25):2424-35
references: 19745215
references: MMWR Morb Mortal Wkly Rep. 2002 Jul 5;51(26):565-7
references: 12139181
references: Clin Infect Dis. 2007 Jan 15;44(2):190-6
references: 17173215
references: Am J Kidney Dis. 2006 Jul;48 Suppl 1:S176-247
references: 16813989
references: Ren Fail. 2001 Jan;23(1):97-106
references: 11256535
references: Lancet. 2010 Jan 2;375(9708):41-8
references: 20018365
references: BMC Infect Dis. 2008 Jul 29;8:102
references: 18664278
references: Artif Organs. 1994 Apr;18(4):301-4
references: 8024480
references: Nephron. 2001 Jun;88(2):138-43
references: 11399916
references: Am J Kidney Dis. 2005 Oct;46(4):706-12
references: 16183426
references: MMWR Recomm Rep. 1997 Apr 4;46(RR-8):1-24
references: 9132580
references: Kidney Int. 2000 Oct;58(4):1758-64
references: 11012910
references: Am J Kidney Dis. 2009 Nov;54(5):912-21
references: 19748717
references: Ann Intern Med. 2008 Apr 15;148(8):596-605
references: 18413621
references: Trans Am Soc Artif Intern Organs. 1978;24:27-31
references: 716012
references: Lancet. 2005 Oct 1;366(9492):1175-81
references: 16198766
references: Nephrol Dial Transplant. 2009 Dec;24(12):3566-72
references: 19846392
references: Lancet. 2006 Apr 8;367(9517):1173-80
references: 16616560
references: Nephrol Dial Transplant. 2003 Dec;18(12):2688-90
references: 14605312
references: Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 2):S221-47
references: 10764341
references: Semin Dial. 2003 May-Jun;16(3):233-44
references: 12753686
references: Postgrad Med J. 1993;69 Suppl 3:S15-7
references: 8290450
references: MMWR Morb Mortal Wkly Rep. 2009 Sep 25;58(37):1029-32
references: 19779397
references: J Am Soc Nephrol. 2003 Jul;14(7):1863-70
references: 12819247
references: Semin Dial. 2007 Sep-Oct;20(5):416-22
references: 17897248
references: Am J Nephrol. 2006;26(2):206-11
references: 16699258
references: Semin Dial. 2004 Jan-Feb;17(1):9-11
references: 14717802
references: Nephrol Dial Transplant. 2008 Aug;23(8):2599-603
references: 18305314
references: Am J Kidney Dis. 1998 Sep;32(3):410-4
references: 9740156
references: Kidney Int. 1998 Jun;53(6):1792-4
references: 9607214
references: Nephron Clin Pract. 2004;96(1):c15-20
references: 14752249
references: Infect Control Hosp Epidemiol. 1999 Sep;20(9):607-9
references: 10501258
references: Blood Purif. 2008;26(4):317-21
references: 18463433
references: Semin Dial. 2003 Jan-Feb;16(1):38-44
references: 12535299
references: Clin Nephrol. 1988 Aug;30(2):63-72
references: 2846218
references: Semin Dial. 2007 Sep-Oct;20(5):440-51
references: 17897251
references: MMWR Morb Mortal Wkly Rep. 1996 Apr 26;45(16):330-3
references: 8602134
references: Chest. 2001 Dec;120(6):1883-7
references: 11742917
references: Immunol Rev. 2001 Dec;184:184-202
references: 12086312
references: Nephron. 2002 Aug;91(4):682-7
references: 12138273
references: Clin Exp Immunol. 2002 Mar;127(3):430-5
references: 11966758
references: Am J Kidney Dis. 2009 Jun;53(6):1034-41
references: 19394731
references: Am J Nephrol. 2000 Jul-Aug;20(4):273-7
references: 10970979
references: Clin Nephrol. 2003 Jun;59(6):436-40
references: 12834175
references: Am J Kidney Dis. 1999 Dec;34(6):1114-24
references: 10585322
references: Semin Dial. 2008 Nov-Dec;21(6):528-38
references: 19000122
references: Clin Nephrol. 2002 Nov;58(5):356-62
references: 12425486
references: Am J Kidney Dis. 2007 Feb;49(2):276-83
references: 17261430
references: J Am Soc Nephrol. 2004 Apr;15(4):1038-45
references: 15034107
references: Clin Infect Dis. 2009 Sep 15;49(6):e66-8
references: 19681710
references: J Med Virol. 2007 Aug;79(8):1176-9
references: 17596830
references: Am J Kidney Dis. 2005 Dec;46(6):997-1011
references: 16310566
references: MMWR Recomm Rep. 1995 Sep 8;44(RR-11):19-34
references: 7565540
references: Kidney Int. 2004 Oct;66(4):1622-32
references: 15458459
references: Am J Kidney Dis. 2007 Aug;50(2):289-95
references: 17660030
references: Clin Exp Immunol. 2007 Mar;147(3):401-11
references: 17302888
references: Am J Infect Control. 2004 May;32(3):155-60
references: 15153927
references: JAMA. 1999 Aug 18;282(7):677-86
references: 10517722
references: Ren Fail. 2003 Sep;25(5):739-46
references: 14575282
references: Semin Dial. 2008 Sep-Oct;21(5):440-6
references: 18397202
references: Int J Tuberc Lung Dis. 1998 Dec;2(12):989-91
references: 9869114
references: Nephrol Dial Transplant. 2002 Oct;17(10):1802-7
references: 12270988
references: MMWR Morb Mortal Wkly Rep. 2009 Oct 9;58(39):1100-1
references: 19816398
references: Nephrol News Issues. 2005 Jun;19(7):37-8, 43
references: 16008022
references: Ann Intern Med. 2005 Mar 15;142(6):451-66
references: 15767623
references: Int J Tuberc Lung Dis. 2004 Jan;8(1):92-7
references: 14974751
references: N Engl J Med. 1986 Jul 10;315(2):91-6
references: 3523240
references: Eur J Clin Microbiol Infect Dis. 1992 May;11(5):403-7
references: 1425710
references: J Am Soc Nephrol. 2003 Jan;14(1):169-79
references: 12506149
references: Life Sci. 2005 Nov 4;77(25):3141-55
references: 16005905