title: Tyrphostin analogs are GPR35 agonists.
abstract: GPR35 is an orphan G protein-coupled receptor that is not well-characterized. Here we employ dynamic mass redistribution (DMR) assays to discover new GPR35 agonists. DMR assays identified tyrphostin analogs as GPR35 agonists, which were confirmed with receptor internalization, Tango β-arrestin translocation, and extracellular-signal-regulated kinase phosphorylation assays. These agonists provide pharmacological tools to study the biology and function of GPR35.
authors: Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, NY 14831, United States.
authors: Huayun
authors: H
authors: Deng
authors: Haibei
authors: H
authors: Hu
authors: Ye
authors: Y
authors: Fang