title: Latent toxoplasmosis reduces gray matter density in schizophrenia but not in controls: voxel-based-morphometry (VBM) study.
abstract: OBJECTIVE
  To address the role of latent T. gondii infection in schizophrenia we studied the influence of latent toxoplasmosis on brain morphology.
  
  
  METHODS
  An optimized voxel-based morphometry of magnetic resonance imaging was analyzed by analysis of variance with diagnosis and seropositivity as factors in 44 schizophrenic patients (12 T. gondii positive) and 56 controls (13 T. gondii positive).
  
  
  RESULTS
  Grey matter (GM) volume was reduced in schizophrenia patients compared with controls in the cortical regions, hippocampus and in the caudate. In the schizophrenia sample we found a significant reduction of GM volume in T. gondii positive comparing with T. gondii-negative patients bilaterally in the caudate, median cingulate, thalamus and occipital cortex and in the left cerebellar hemispheres. T. gondii-positive and -negative controls did not differ in any cluster. Among participants seropositive to T. gondii the reduction of GM in the schizophrenia subjects was located in the same regions when comparing the entire sample (11,660 over-threshold voxels (P ≤ 0.05, FWR corrected). The differences between T. gondii-negative patients and controls consisted only of 289 voxels in temporal regions.
  
  
  CONCLUSIONS
  Our study is the first to document that latent toxoplasmosis reduces GM in schizophrenia but not in controls.
authors: Prague Psychiatric Centre, Faculty of Science of Charles University, Prague, Czech Republic. horacek@pcp.lf3.cuni.cz
authors: Jiri
authors: J
authors: Horacek
authors: Jaroslav
authors: J
authors: Flegr
authors: Jaroslav
authors: J
authors: Tintera
authors: Karin
authors: K
authors: Verebova
authors: Filip
authors: F
authors: Spaniel
authors: Tomas
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authors: Novak
authors: Martin
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authors: Brunovsky
authors: Vera
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authors: Bubenikova-Valesova
authors: David
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authors: Holub
authors: Tomas
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authors: Palenicek
authors: Cyril
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authors: Höschl