title: Enantioselective synthesis of diverse sulfinamides and sulfinylferrocenes from phenylglycine-derived chiral sulfinyl transfer agent.
abstract: A new chiral sulfinyl transfer auxiliary derived from readily available phenylglycine was developed. This auxiliary is utilized to synthesize a diverse array of alkyl- and arylsulfinamides and sulfinylferrocenes in high yields and excellent ee's. The desired products are produced in a one-pot sequence from the oxathiazolidine 2-oxide by two sequential nucleophilic additions that proceed in a stereospecific manner.
authors: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States. shan@rdg.boehringer-ingelheim.com
authors: Zhengxu S
authors: ZS
authors: Han
authors: Angelica M
authors: AM
authors: Meyer
authors: Yibo
authors: Y
authors: Xu
authors: Yongda
authors: Y
authors: Zhang
authors: Robert
authors: R
authors: Busch
authors: Sherry
authors: S
authors: Shen
authors: Nelu
authors: N
authors: Grinberg
authors: Bruce Z
authors: BZ
authors: Lu
authors: Dhileep
authors: D
authors: Krishnamurthy
authors: Chris H
authors: CH
authors: Senanayake