title: Conversion from cyclosporine to sirolimus in chronic renal allograft dysfunction: a 4-year prospective study.
abstract: OBJECTIVE
  The long-term use of cyclosporine always contributes to chronic renal allograft dysfunction. Converting from cyclosporine to sirolimus and reducing cyclosporine dosage under high mycophenolate mofetil levels are 2 common therapies. Their efficacy and safety have not been compared in Chinese patients.
  
  
  METHODS
  In this prospective, open label, randomized study, 51 kidney recipients with an estimated glomerular filtration rate between 30 and 60 mL/min/1.73 m² were enrolled. Patients in the sirolimus group (n=22) initiated sirolimus 12 hours after cessation of cyclosporine. Patients in the cyclosporine group (n=29) significantly reduced cyclosporine dosage under high mycophenolate mofetil dosages. Both groups were followed-up for 4 years.
  
  
  RESULTS
  The baseline estimated glomerular filtration rate was 36.46 ± 6.22 mL/min/1.73 m² in sirolimus group and 36.07 ± 6.18 mL/min/1.73 m² in the cyclosporine group (P = NS). In cyclosporine group, the estimated glomerular filtration rate declined significantly at 12, 18, 24, 30, 36, 42, and 48 months after inclusion compared with baseline, and was lower than the sirolimus group at 30, 36, 42, and 48 months after inclusion (P < .05). As for the endpoints of graft loss and return to dialysis, the 4-year graft survival was 77.3% in the sirolimus group and 55.2% in the cyclosporine group (P = NS). As for the endpoint of serum creatinine doubling, 4-year survival was 77.3% in the sirolimus group and 41.4% in the cyclosporine group (P < .05). Three patients in sirolimus group (2 acute rejections, 1 pneumonia) and 2 patients in the cyclosporine group (owing to acute rejection) dropped out (P = NS).
  
  
  CONCLUSIONS
  Conversion from cyclosporine to sirolimus could improve long-term survival of renal grafts in Chinese patients.
authors: Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, PR China.
authors: Fei
authors: F
authors: Han
authors: Jianyong
authors: J
authors: Wu
authors: Hongfeng
authors: H
authors: Huang
authors: Xiaohui
authors: X
authors: Zhang
authors: Qiang
authors: Q
authors: He
authors: Yimin
authors: Y
authors: Wang
authors: Suya
authors: S
authors: Wang
authors: Huiping
authors: H
authors: Wang
authors: Jianghua
authors: J
authors: Chen