title: Relationship between plasma inflammatory markers and platelet aggregation in patients with clopidogrel resistance after angioplasty.
abstract: We evaluated the relationship between plasma inflammation markers and clopidogrel resistance in patients after stent implantation. The plasma levels of C-reactive protein (CRP), P-selectin, platelet soluble CD40 ligand (sCD40L), interleukin 6 (IL-6) and platelet aggregation were measured in 352 patients undergoing percutaneous coronary intervention (PCI) at baseline and after 6 months. The plasma levels of CRP, P-selectin, sCD40L, IL-6 was higher in 65 (18.5%) patients with clopidogrel resistance than in those with normal responsiveness at 6 months after PCI. There was a significant positive correlation between soluble CD40L levels and platelet aggregation (r = .28, P < .05). Diabetes (DM) and sCD40L level were independent predictors for unresponsiveness after stent implantation according to stepwise multivariate analyses. The hazard ratio (HR) for sCD40L level was 3.02 (95% CI = 1.28 to 3.25; P = .036) and for DM 2.53 (95% CI = 1.28 to 6.55, P = .03). We conclude that sCD40L and DM may influence clopidogrel resistance.
authors: Department of Cardiology, Anzhen Hospital, Capital Medical University, Beijing, China.
authors: Hailong
authors: H
authors: Ge
authors: Yujie
authors: Y
authors: Zhou
authors: Xiaoli
authors: X
authors: Liu
authors: Xiaomin
authors: X
authors: Nie
authors: Zhijian
authors: Z
authors: Wang
authors: Yonghe
authors: Y
authors: Guo
authors: Wangjun
authors: W
authors: Chen
authors: Qing
authors: Q
authors: Yang