title: Role of paraxial mesoderm in limb/flank regionalization of the trunk lateral plate.
abstract: To understand the developmental mechanism that determines limb size and the consequent limb-to-trunk proportions in the tetrapod body, we investigated the role of the paraxial mesoderm in the specification of the limb and flank fields in the chick embryo. We found that the paraxial mesoderm subjacent to the limb field can affect the size of the limb bud along the anterior-posterior and proximal-distal axes. We also found that the paraxial mesoderm subjacent to the flank plays roles in suppressing the emergence and growth of the limb bud and in promoting flank-specific apoptosis in the lateral plate mesoderm. Our results suggest that signals from the paraxial mesoderm specify the limb and flank fields in the competent lateral plate mesoderm.
authors: Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
authors: Miyuki
authors: M
authors: Noro
authors: Hiroki
authors: H
authors: Yuguchi
authors: Taeko
authors: T
authors: Sato
authors: Takanobu
authors: T
authors: Tsuihiji
authors: Sayuri
authors: S
authors: Yonei-Tamura
authors: Hitoshi
authors: H
authors: Yokoyama
authors: Yoshio
authors: Y
authors: Wakamatsu
authors: Koji
authors: K
authors: Tamura