title: Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation.
abstract: Recently, investigation of new neurons in memory formation has focused on a specific function-pattern separation. However, it has been difficult to reconcile the form of separation tested in behavioral tasks with how it is conceptualized according to computational and electrophysiology perspectives. Here, we propose a memory resolution hypothesis that considers the unique information contributions of broadly tuned young neurons and highly specific mature neurons and describe how the fidelity of memories can relate to spatial and contextual discrimination. See the related Perspective from Sahay, Wilson, and Hen, "Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb," in this issue of Neuron.
authors: Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors: James B
authors: JB
authors: Aimone
authors: Wei
authors: W
authors: Deng
authors: Fred H
authors: FH
authors: Gage
references: Nat Neurosci. 2008 Aug;11(8):901-7
references: 18622400
references: Cognition. 2009 Aug;112(2):229-40
references: 19481201
references: Hippocampus. 2010 Oct;20(10):1109-23
references: 20872737
references: PLoS One. 2009;4(5):e5464
references: 19421325
references: Proc Natl Acad Sci U S A. 1982 Apr;79(8):2554-8
references: 6953413
references: Nat Neurosci. 2006 Jun;9(6):723-7
references: 16732202
references: Nature. 2011 Apr 28;472(7344):466-70
references: 21460835
references: Hippocampus. 2008;18(9):955-64
references: 18493930
references: Nat Rev Neurosci. 2010 May;11(5):339-50
references: 20354534
references: Hippocampus. 1992 Apr;2(2):189-99
references: 1308182
references: Trends Cogn Sci. 2010 Jul;14(7):325-37
references: 20471301
references: Neuron. 2010 Dec 22;68(6):1051-8
references: 21172608
references: Nat Neurosci. 2002 Aug;5(8):790-5
references: 12118256
references: Behav Brain Res. 2006 Apr 25;169(1):142-9
references: 16455144
references: J Neurosci. 2005 Nov 2;25(44):10074-86
references: 16267214
references: Prog Brain Res. 2007;163:567-76
references: 17765738
references: Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2367-72
references: 20133882
references: Neuron. 1999 Feb;22(2):233-42
references: 10069330
references: Prog Brain Res. 2007;163:3-22
references: 17765709
references: Cell. 2009 Nov 13;139(4):814-27
references: 19914173
references: Philos Trans R Soc Lond B Biol Sci. 1971 Jul 1;262(841):23-81
references: 4399412
references: Science. 2007 Jul 6;317(5834):94-9
references: 17556551
references: Hippocampus. 1993 Apr;3(2):165-82
references: 8353604
references: Hippocampus. 2005;15(6):722-38
references: 15986407
references: Neuroscience. 2008 Jul 17;154(4):1155-72
references: 18554812
references: J Neurosci. 2007 Mar 21;27(12):3252-9
references: 17376985
references: Neuron. 2007 May 24;54(4):559-66
references: 17521569
references: Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4642-6
references: 17360577
references: Eur J Neurosci. 2011 Mar;33(6):1160-9
references: 21395860
references: Hippocampus. 2008;18(10):1064-73
references: 18651615
references: Hippocampus. 1994 Dec;4(6):661-82
references: 7704110
references: Hippocampus. 2009 Apr;19(4):321-37
references: 18958849
references: PLoS Comput Biol. 2010 Apr 29;6(4):e1000759
references: 20454678
references: Curr Opin Neurobiol. 2011 Apr;21(2):360-4
references: 21367599
references: Cell. 2008 Feb 22;132(4):645-60
references: 18295581
references: J Neurosci. 2009 Oct 28;29(43):13532-42
references: 19864566
references: Science. 2009 Jul 10;325(5937):210-3
references: 19590004
references: Nat Neurosci. 2007 Mar;10(3):355-62
references: 17277773
references: PLoS One. 2008 Apr 09;3(4):e1959
references: 18509506
references: Hippocampus. 2001;11(6):626-36
references: 11811656
references: Hippocampus. 2004;14(1):66-76
references: 15058484
references: Hippocampus. 2010 Oct;20(10):1124-5
references: 20848611
references: Neuron. 2009 Jan 29;61(2):187-202
references: 19186162
references: Neuroscience. 2005;130(4):843-52
references: 15652983
references: Science. 2007 Feb 16;315(5814):961-6
references: 17303747
references: Trends Cogn Sci. 2007 Feb;11(2):70-6
references: 17174137
references: Science. 2008 Mar 21;319(5870):1640-2
references: 18356518