title: [Inhibition of three pentacyclic triterpenoids on calcium-induced liver mitochondrial permeability transition in mice].
abstract: OBJECTIVE
  To study effects of three pentacyclic triterpenoids, oleanolic acid (OA), ursolic acid (UA) and asiatic acid (AA) on Ca(2+)-induced liver mitochondrial permeability transition (MPT).
  
  
  METHODS
  Effects of three compounds on liver MPT induced by Ca2+ were assessed by measuring the change in mitochondrial swelling, mitochondrial membrane potential and release of matrix Ca2+ in vitro.
  
  
  RESULTS
  Obvious mitochondrial swelling, loss of mitochondrial membrane potential and release of matrix Ca2+ occurred after the addition of 50 micromol x L(-1) Ca2+. However, preincubation with 50 mg x L(-1) OA, UA or AA significantly blocked the above changes. In addition, it was also found that there are differences in the inhibitions of three compounds on liver MPT induced by Ca2+.
  
  
  CONCLUSIONS
  Three pentacyclic triterpenoids, OA, UA and AA, have significant mitochondrial protection through blocking on liver MPT and the inhibition on liver MPT of AA is stronger than that of UA and OA.
authors: Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, School of Life Science and Technology, Yancheng Teachers College, Yancheng 224051, China.
authors: Xinhui
authors: X
authors: Tang
authors: Lifang
authors: L
authors: Yan
authors: Lizhi
authors: L
authors: Xu
authors: Jing
authors: J
authors: Gao