title: Cocaine-related attentional bias following trauma cue exposure among cocaine dependent in-patients with and without post-traumatic stress disorder.
abstract: OBJECTIVE
  Although the co-occurrence of post-traumatic stress disorder (PTSD) and cocaine dependence is associated with a wide range of negative clinical outcomes, little is known about the mechanisms that underlie this association. This study investigated one potential mechanism-attentional bias to cocaine imagery following trauma cue exposure.
  
  
  METHODS
  Male and female cocaine-dependent in-patients with and without PTSD were exposed to both a neutral and personalized trauma script on separate days, followed by a visual dot-probe task. A 2 (PTSD versus non-PTSD) × 2 (neutral versus trauma script) × 2 (male versus female) design was used to examine hypotheses.
  
  
  METHODS
  Participants were recruited from a residential substance use disorder (SUD) treatment center.
  
  
  METHODS
  Participants were 60 trauma-exposed cocaine dependent in-patients, 30 with current PTSD and 30 without a history of PTSD.
  
  
  METHODS
  Attentional bias was assessed using a visual dot-probe task depicting cocaine-related imagery following both a neutral script and personalized trauma script.
  
  
  RESULTS
  Following neutral script exposure, PTSD (versus non-PTSD) participants exhibited an attentional bias away from cocaine imagery. This effect was reversed following trauma script exposure, with PTSD participants exhibiting a greater attentional bias towards the location of cocaine imagery than non-PTSD participants. Severity of subjective distress following trauma script exposure predicted level of attentional bias among PTSD participants.
  
  
  CONCLUSIONS
  Cocaine appears to serve an emotion-regulating function among post-traumatic stress disorder patients and may be a potential target for brief post-traumatic stress disorder-substance use disorder interventions that can facilitate residential substance use disorder treatment retention.
authors: Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA. mtull@umc.edu
authors: Matthew T
authors: MT
authors: Tull
authors: Michael J
authors: MJ
authors: McDermott
authors: Kim L
authors: KL
authors: Gratz
authors: Scott F
authors: SF
authors: Coffey
authors: Carl W
authors: CW
authors: Lejuez
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