title: Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
abstract: Thymidine kinase is the key enzyme in salvage pathway for pyrimidine nucleotide synthesis. High activities of thymidine kinase have been found in rapidly proliferating normal, neoplastic tissues and sera from patients with various diseases including lymphoma, leukemias and small cell lung cancer. We investigated the serum thymidine kinase activities and the colorectal carcinomas in rats treated with 1,2-dimethylhydrazine. The positive correlations between serum thymidine kinase activities and numbers of total and large tumors were observed. These findings suggest the measurement of serum thymidine kinase activity may be clinically valuable in an early stage of the colonic carcinogenesis.
authors: TOKYO MED & DENT UNIV,MED RES INST,BUNKYO KU,TOKYO 113,JAPAN. UNIV TSUKUBA,COLL MED TECHNOL & NURSING,DEPT CLIN CHEM,TSUKUBA,IBARAKI,JAPAN. TOKYO METROPOLITAN BOKUTO GEN HOSP,DIV BLOOD TRANSFUS,TOKYO,JAPAN.
authors: K
authors: K
authors: Kuwa
authors: H
authors: H
authors: Kudo
authors: S
authors: S
authors: Sakamoto