title: Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes.
abstract: A series of 2-amino-4-aryl-3-cyano-7- (dimethylamino)-4H-chromenes was synthesized by condensation of 3- (dimethylamino) phenol, an aromatic aldehyde and malonitrile in ethanol containing piperidine. The assignments of the structure of all synthesized compounds were based on spectral data (IR, Mass and(1)H NMR). The cytotoxic activities of the synthesized compounds against six human tumor cell lines were determined by MTT assay. Several compounds showed significant cytotoxic activity.
authors: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, I.R.Iran.
authors: M
authors: M
authors: Vosooghi
authors: S
authors: S
authors: Rajabalian
authors: M
authors: M
authors: Sorkhi
authors: M
authors: M
authors: Badinloo
authors: M
authors: M
authors: Nakhjiri
authors: A S
authors: AS
authors: Negahbani
authors: A
authors: A
authors: Asadipour
authors: M
authors: M
authors: Mahdavi
authors: A
authors: A
authors: Shafiee
authors: A
authors: A
authors: Foroumadi
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