title: Clinical course and management of paclitaxel extravasation.
abstract: Four case reports describing our experience with clinical course and management of paclitaxel extravasation are presented. Local reactions included swelling, mild pain, erythema, induration and hyperpigmentation, but no ulceration. Two patients were treated with cooling only while two further patients received additional hyaluronidase injections subcutaneously. The latter patients suffered longer from symptoms. Local reaction resolved within two weeks and paclitaxel treatment was continued in 3 of 4 patients without further complications. Overall, paclitaxel extravasation induced only mild soft tissue reaction and cooling should be considered standard treatment.
authors: UNIV ZURICH HOSP,DEPT GYNECOL & OBSTET,CH-8090 ZURICH,SWITZERLAND. BRISTOL MYERS SQUIBB,D-80632 MUNICH,GERMANY.
authors: A
authors: A
authors: Dubois
authors: M
authors: M
authors: Fehr
authors: H
authors: H
authors: Bochtler
authors: O
authors: O
authors: Koechli