title: "Tako-tsubo" cardiomyopathy and duloxetine use.
abstract: We report the case of a 68-year-old woman in whom the use of duloxetine, a potent serotonin and norepinephrine reuptake inhibitor, was associated with "tako-tsubo" cardiomyopathy (TTC). Although several pathophysiological mechanisms for TTC have been proposed, available evidence suggests that an excess of catecholamines may play a major role. Our patient had a history of myocardial infarction with normal coronary arteries, probably the first manifestation of TTC. We speculate that duloxetine may have precipitated TTC by increasing plasma catecholamine concentration in a predisposed patient.
authors: Division of Cardiology, San Giuseppe Moscati Hospital, Avellino, Italy. francesco.rotondi@tin.it
authors: Francesco
authors: F
authors: Rotondi
authors: Fiore
authors: F
authors: Manganelli
authors: Giannignazio
authors: G
authors: Carbone
authors: Giovanni
authors: G
authors: Stanco