title: Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia.
abstract: Methylation profile was analyzed in ninety-five patients with childhood acute lymphoblastic leukemia (ALL). Methylation of both MGMT and p16 genes were associated with higher age (p=0.01 and p=0.03, respectively). Methylation of both p15 and SHP1 genes occurred more frequently in T-ALL than in precursor B-ALL (p=0.02 and p=0.01, respectively). In contrast, methylation of the DAPK gene was more frequent in precursor B-ALL (p=0.01). Patients with methylation of multiple genes more likely had T cell phenotype, and are classified as medium/high risk (p=0.004 and p=0.03, respectively). These results suggest that methylation status is associated with clinicopathological features in childhood ALL.
authors: Department of Medicine, Kochi Medical School, Oko-cho, Nankoku, Kochi 783-8505, Japan. takeuti@kochi-u.ac.jp
authors: Seisho
authors: S
authors: Takeuchi
authors: Masahide
authors: M
authors: Matsushita
authors: Martin
authors: M
authors: Zimmermann
authors: Takayuki
authors: T
authors: Ikezoe
authors: Naoki
authors: N
authors: Komatsu
authors: Taku
authors: T
authors: Seriu
authors: Martin
authors: M
authors: Schrappe
authors: Claus R
authors: CR
authors: Bartram
authors: H Phillip
authors: HP
authors: Koeffler
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