title: Pediatric sensorineural hearing loss, part 2: syndromic and acquired causes.
abstract: This article is the second in a 2-part series reviewing neuroimaging in childhood SNHL. Previously, we discussed the clinical work-up of children with hearing impairment, the classification of inner ear malformations, and congenital nonsyndromic causes of hearing loss. Here, we review and illustrate the most common syndromic hereditary and acquired causes of childhood SNHL, with an emphasis on entities that demonstrate inner ear abnormalities on cross-sectional imaging. Syndromes discussed include BOR syndrome, CHARGE syndrome, Pendred syndrome, Waardenburg syndrome, and X-linked hearing loss with stapes gusher. We conclude the article with a review of acquired causes of childhood SNHL, including infections, trauma, and neoplasms.
authors: Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. bhuang@med.unc.edu
authors: B Y
authors: BY
authors: Huang
authors: C
authors: C
authors: Zdanski
authors: M
authors: M
authors: Castillo
references: Nat Genet. 1996 Apr;12(4):421-3
references: 8630497
references: Int J Pediatr Otorhinolaryngol. 2008 Apr;72(4):529-34
references: 18255162
references: Int J Audiol. 2008 Sep;47(9):560-5
references: 18821225
references: Laryngoscope. 1998 Jun;108(6):816-21
references: 9628495
references: J Pediatr. 1981 Aug;99(2):223-7
references: 6166737
references: Neuroimaging Clin N Am. 2009 Aug;19(3):321-37
references: 19733311
references: Laryngoscope. 1992 Jun;102(6):600-3
references: 1602907
references: AJNR Am J Neuroradiol. 1999 Feb;20(2):281-4
references: 10094354
references: Otol Neurotol. 2002 Mar;23(2):200-7
references: 11875350
references: Neuroradiology. 1998 Jul;40(7):462-5
references: 9730349
references: Ann N Y Acad Sci. 1997 Dec 29;830:291-8
references: 9616687
references: Otolaryngol Head Neck Surg. 1991 Mar;104(3):320-6
references: 1902932
references: Clin Genet. 2008 Jan;73(1):14-23
references: 18005182
references: Pediatr Neurosurg. 2009;45(3):214-9
references: 19521135
references: Am J Otol. 1999 Jan;20(1):115-32
references: 9918184
references: Eur J Hum Genet. 2007 Apr;15(4):389-99
references: 17299439
references: Laryngoscope. 2003 Nov;113(11):2035-41
references: 14603070
references: Am J Med Genet A. 2005 Mar 15;133A(3):306-8
references: 15666308
references: AJNR Am J Neuroradiol. 2006 Sep;27(8):1663-71
references: 16971610
references: Am J Otolaryngol. 1992 Mar-Apr;13(2):113-4
references: 1642327
references: Otolaryngol Head Neck Surg. 1999 Jul;121(1):130-2
references: 10388895
references: Int J Pediatr Otorhinolaryngol. 2004 Sep;68(9):1193-8
references: 15302152
references: J Child Neurol. 2005 Nov;20(11):914-5
references: 16417863
references: Otolaryngol Head Neck Surg. 2010 May;142(5):772-3
references: 20416474
references: Br J Neurosurg. 2009 Jun;23(3):315-7
references: 19533466
references: Eur J Radiol. 1998 Nov;29(1):71-5
references: 9934561
references: J Med Genet. 1996 Dec;33(12):1037-40
references: 9004139
references: Curr Opin Otolaryngol Head Neck Surg. 2003 Oct;11(5):340-6
references: 14502064
references: J Trauma. 1996 Mar;40(3):488-96
references: 8601878
references: Arch Otolaryngol Head Neck Surg. 1999 May;125(5):517-21
references: 10326808
references: Laryngoscope. 2005 Oct;115(10):1855-62
references: 16222209
references: Arch Otolaryngol Head Neck Surg. 1993 Jan;119(1):49-54
references: 8417743
references: Radiology. 2005 May;235(2):537-40
references: 15758191
references: Laryngoscope. 2009 Apr;119(4):832
references: 19213038
references: Hum Mutat. 2010 Apr;31(4):391-406
references: 20127975
references: Clin Radiol. 1998 Apr;53(4):268-73
references: 9585042
references: Int J Pediatr Otorhinolaryngol. 2008 Jun;72(6):905-9
references: 18355927
references: Laryngoscope. 1992 Feb;102(2):129-34
references: 1738283
references: Clin Genet. 2010 Dec;78(6):524-32
references: 20412083
references: AJNR Am J Neuroradiol. 1993 Jan-Feb;14(1):37-45
references: 8427110
references: N Engl J Med. 2006 May 18;354(20):2151-64
references: 16707752
references: Laryngoscope. 2006 Jul;116(7):1273-5
references: 16826074
references: Am J Med Genet A. 2007 Jul 15;143A(14):1671-8
references: 17238186
references: J Otolaryngol. 1992 Aug;21(4):262-4
references: 1527831
references: Otolaryngol Clin North Am. 2005 Aug;38(4):671-84, ix
references: 16005725
references: Am J Otol. 1994 Mar;15(2):177-82
references: 8172298
references: Laryngoscope. 1984 Jun;94(6):746-52
references: 6727511
references: Laryngoscope. 2002 Jan;112(1):8-17
references: 11802031
references: Arch Dis Child. 1999 Dec;81(6):496-9
references: 10569966
references: Childs Nerv Syst. 2009 Feb;25(2):247-51
references: 18690462
references: Ann Otol Rhinol Laryngol Suppl. 1995 Apr;165:15-8
references: 7717629
references: AJNR Am J Neuroradiol. 2003 Jun-Jul;24(6):1130-2
references: 12812938