title: Bacterial etiology and serotypes of acute otitis media in Mexican children.
abstract: Streptococcus pneumoniae and Haemophilus influenzae have been consistently reported to be the two major bacterial pathogens responsible for acute otitis media (AOM), mainly from studies in the US and Europe. However, data on bacterial pathogens causing AOM in Latin America are limited. Understanding the relative importance of these pathogens in a specific setting, the serotype distribution, and their antibiotic susceptibility levels is important to provide local vaccine and treatment recommendations. We therefore conducted a prospective, multi-center, tympanocentesis-based epidemiological study of Mexican children three months to less than five years of age. Fifty percent of episodes were in children who had received at least one dose of PCV7. Overall, 64% of samples were culture positive for bacterial pathogens. H. influenzae and S. pneumoniae were the leading causes of bacterial AOM, detected in 34% and 29% of AOM episodes, respectively. The most commonly isolated S. pneumoniae serotypes were 19A, 19F and 23F. All H. influenzae isolates were identified as non-typeable. Seventy-four percent of S. pneumoniae were susceptible to penicillin, while 97% were susceptible to amoxicillin/clavulanate. All H. influenzae samples were susceptible to amoxicillin/clavulanate and cefotaxime, 95% to cefuroxime and 75% to ampicillin. Both S. pneumoniae and non-typable H. influenzae represent important targets for vaccination strategies to reduce AOM in Mexican children.
authors: Instituto Nacional de Pediatria, Insurgentes Sur 3700-C, Insurgentes Cuicuilco, México 04530, Mexico. mermacpar@hotmail.com
authors: Mercedes Macias
authors: MM
authors: Parra
authors: Gerardo Martinez
authors: GM
authors: Aguilar
authors: Gabriela
authors: G
authors: Echaniz-Aviles
authors: Romulo Galo
authors: RG
authors: Rionda
authors: Maria de Los Angeles Meza
authors: Mde L
authors: Estrada
authors: Yolanda
authors: Y
authors: Cervantes
authors: Jean-Yves
authors: JY
authors: Pirçon
authors: Melissa K
authors: MK
authors: Van Dyke
authors: Romulo E
authors: RE
authors: Colindres
authors: William P
authors: WP
authors: Hausdorff