title: Nodular lymphocyte predominant Hodgkin's disease progressing to a large B-cell lymphoma without previous treatment.
abstract: The nodular form of lymphocyte predominance Hodgkin's disease presents particular clinical and biological features that have set it apart as a distinct clinicopathological entity. It has an indolent course with long-term survival despite frequent localized relapses, and a remarkable tendency to progress into a B-cell non-Hodgkin's lymphoma. Biological evidence strongly point to a B-cell proliferation from the start. We report the unique case of a patient with nodular lymphocyte predominant Hodgkin's disease in stage I who had all disease removed for diagnosis and did not receive fu;ther treatment. He relapsed in the same lymph node area twelve years later, and the biopsy was now consistent with a large B-cell lymphoma. The histopathological and immunophenotypic profiles clearly show the identity of the two lymph node proliferations. This phenomenon exemplifies the growing inter-relashionship between Hodgkin's disease and non-Hodgkin's lymphomas.
authors: UNIV FED RIO DE JANEIRO,HOSP CLEMENTINO FRAGA FILHO,SERV HEMATOL,BR-21941590 ILHA FUNDACAO,BRAZIL. UNIV FED RIO DE JANEIRO,HOSP CLEMENTINO FRAGA FILHO,SERV PATHOL,BR-21941590 ILHA FUNDACAO,BRAZIL.
authors: J
authors: J
authors: Morais
authors: M
authors: M
authors: Nucci
authors: V
authors: V
authors: Dearaujo
authors: W
authors: W
authors: Pulcheri
authors: N
authors: N
authors: Spector