title: Bisphosphonates and atypical fractures of femur.
abstract: Bisphosphonates are the most widely prescribed medicines for the treatment of osteoporosis and have generally been regarded as well-tolerated and safe drugs. Since 2005, there have been numerous case reports about atypical fractures of the femur linked to long-term treatment of osteoporosis with bisphosphonates. Some attempts to characterize pathophysiology and epidemiology of these fractures have been published as well. However, as the American Society for Bone and Mineral Research (ASBMR) concluded in their task force report, the subject warrants further studies.
authors: Department of Orthopedics, Traumatology and Hand Surgery, Kuopio University Hospital, Puijonlaaksontie 2, P.O. Box 1777, 70211 Kuopio, Finland.
authors: Tero
authors: T
authors: Yli-Kyyny
references: J Bone Miner Res. 2009 Jun;24(6):1095-102
references: 19113931
references: J Clin Endocrinol Metab. 2000 Nov;85(11):4118-24
references: 11095442
references: J Bone Miner Res. 2009 Oct;24(10):1736-40
references: 19419297
references: Lancet. 1996 Dec 7;348(9041):1535-41
references: 8950879
references: Clin Endocrinol (Oxf). 2010 Feb;72(2):161-8
references: 19302584
references: J Clin Endocrinol Metab. 2000 Sep;85(9):3109-15
references: 10999794
references: N Engl J Med. 2008 Mar 20;358(12):1304-6
references: 18354114
references: Curr Osteoporos Rep. 2010 Mar;8(1):34-9
references: 20425089
references: Clin Sports Med. 2006 Jan;25(1):117-28, x
references: 16324978
references: Bone. 2010 Aug;47(2):169-80
references: 20493982
references: J Bone Joint Surg Br. 2007 Mar;89(3):349-53
references: 17356148
references: J Clin Endocrinol Metab. 2005 Mar;90(3):1294-301
references: 15598694
references: Orthopedics. 2010 Dec;33(12):867
references: 21117559
references: Geriatrics. 2006 Jan;61(1):31-3
references: 16405362
references: J Clin Endocrinol Metab. 2000 Feb;85(2):720-6
references: 10690882
references: Osteoporos Int. 2011 Mar;22(3):993-1001
references: 21165600
references: J Bone Miner Res. 2007 Oct;22(10):1502-9
references: 17824840
references: J Clin Invest. 1997 Sep 15;100(6):1475-80
references: 9294113
references: Bone. 2001 May;28(5):524-31
references: 11344052
references: J Bone Miner Res. 2008 Jan;23(1):6-16
references: 17892374
references: N Engl J Med. 2006 Nov 9;355(19):2048-50
references: 17093260
references: J Bone Miner Res. 2000 Apr;15(4):613-20
references: 10780852
references: Drug Saf. 2009;32(9):775-85
references: 19670917
references: Calcif Tissue Int. 2009 Jul;85(1):37-44
references: 19548019
references: Acta Orthop. 2009 Aug;80(4):413-5
references: 19568963
references: N Engl J Med. 1995 Nov 30;333(22):1437-43
references: 7477143
references: J Clin Endocrinol Metab. 2008 Aug;93(8):2948-52
references: 18522980
references: JAMA. 2006 Dec 27;296(24):2927-38
references: 17190893
references: Radiol Case Rep. 2016 Oct 04;4(1):261
references: 27843524
references: J Bone Miner Res. 2010 Nov;25(11):2267-94
references: 20842676
references: Bone. 2007 Sep;41(3):378-85
references: 17597017
references: J Orthop Trauma. 2010 Feb;24(2):75-81
references: 20101130
references: J Orthop Trauma. 2008 May-Jun;22(5):346-50
references: 18448990
references: Injury. 2008 Feb;39(2):224-31
references: 18222447
references: Arch Orthop Trauma Surg. 2007 Sep;127(7):597-601
references: 17572902
references: J Bone Joint Surg Am. 2009 Nov;91(11):2556-61
references: 19884427
references: Hong Kong Med J. 2007 Dec;13(6):485-9
references: 18057440
references: Osteoporos Int. 2011 Feb;22(2):373-90
references: 21085935
references: N Engl J Med. 2010 May 13;362(19):1761-71
references: 20335571