title: Enhancing the effect of repetitive I-wave paired-pulse TMS (iTMS) by adjusting for the individual I-wave periodicity.
abstract: BACKGROUND
  Repeated application of paired-pulse TMS over the primary motor cortex (M1) in human subjects with an inter-pulse interval (IPI) of 1.5 ms (iTMS(1.5 ms)) has been shown to significantly increase paired-pulse MEP (ppMEP) amplitudes during the stimulation period and increased single-pulse MEP amplitudes for up to 10 minutes after termination of iTMS.
  
  
  RESULTS
  Here we show in a cross-over design that a modified version of the iTMS(1.5 ms) protocol with an I-wave periodicity adjusted to the individual I1-peak wave latency (iTMS(adj)) resulted in a stronger effect on ppMEPs relative to iTMS(1.5 ms).
  
  
  CONCLUSIONS
  Based on these findings, our results indicate that the efficiency of iTMS strongly depends on the individual choice of the IPI and that parameter optimization of the conventional iTMS(1.5 ms) protocol might improve the outcome of this novel non-invasive brain stimulation technique.
authors: Max Planck Institute for Human Cognitive and Brain Sciences, Department of Neurology, D-04103 Leipzig, Germany.
authors: Sebastian
authors: S
authors: Sewerin
authors: Marco
authors: M
authors: Taubert
authors: Henning
authors: H
authors: Vollmann
authors: Virginia
authors: V
authors: Conde
authors: Arno
authors: A
authors: Villringer
authors: Patrick
authors: P
authors: Ragert
references: Exp Brain Res. 2011 Jan;208(2):229-35
references: 21069307
references: J Neurosci Methods. 2007 Sep 30;165(2):265-9
references: 17628691
references: Exp Brain Res. 2009 Feb;193(1):1-7
references: 18850091
references: J Physiol. 1998 Aug 15;511 ( Pt 1):181-90
references: 9679173
references: Brain Stimul. 2009 Jan;2(1):2-13
references: 20633398
references: J Physiol. 2008 Dec 1;586(23):5717-25
references: 18845611
references: Clin Neurophysiol. 2007 Jun;118(6):1193-7
references: 17398148
references: Exp Brain Res. 2006 Nov;175(4):626-32
references: 16783555
references: Electroencephalogr Clin Neurophysiol. 1994 Aug;91(2):79-92
references: 7519144
references: Neurology. 1997 May;48(5):1398-403
references: 9153480
references: Clin Neurophysiol. 2006 Dec;117(12):2584-96
references: 16890483
references: Neuron. 2005 Jan 20;45(2):201-6
references: 15664172
references: Exp Brain Res. 2007 Jul;180(4):583-93
references: 17562028
references: J Physiol. 1989 May;412:449-73
references: 2489409
references: Clin Neurophysiol. 2006 Jan;117(1):61-6
references: 16326137
references: J Physiol. 2002 Jan 1;538(Pt 1):253-61
references: 11773332
references: J Clin Neurophysiol. 2000 Jul;17(4):397-405
references: 11012042
references: Neuropsychologia. 1971 Mar;9(1):97-113
references: 5146491