title: Treatment of human cancers by NO-releasing reagents related to Mn-SOD.
abstract: Nitric oxide (NO) plays various roles in organisms, including its anti-tumor effect. But it was not well known how NO actually influences human cancer cells and destroys them. We investigated the relation between NO and SODs using S-nitroso-N-acetyl penicillamine (SNAP), an NO releasing reagent. In several cancer cells treated with SNAP, the expression of manganese-superoxide dismutase (Mn-SOD) mRNA and the enzymatic activity of Mn-SOD were both enhanced. These results suggest that some human cancers which are resistant to NO may enhance the expression of Mn-SOD in order to protect themselves against NO radicals. Such mechanism is also expected to offer a clue to the practical use of NO donors as an anti-cancer drug.
authors: NATL INST LONGEV SCI,OBU,AICHI 474,JAPAN. NAGOYA UNIV,SCH MED,DEPT SURG 2,SHOWA KU,NAGOYA,AICHI 466,JAPAN. NAGOYA UNIV,SCH MED,DEPT IMMUNOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN.
authors: H
authors: H
authors: Takeshita
authors: K
authors: K
authors: Isobe
authors: S
authors: S
authors: Akiyama
authors: K
authors: K
authors: Ito
authors: Y
authors: Y
authors: Kasai
authors: I
authors: I
authors: Nakashima
authors: H
authors: H
authors: Takagi