title: αvβ3-Integrin-targeting lanthanide complex: synthesis and evaluation as a tumor-homing luminescent probe.
abstract: The application of lanthanide complexes in the time-resolved fluorescence imaging of living cells has emerged in the last few decades, providing high-contrast images of cells through detection of the delayed emission. In the present study, we synthesized novel trivalent lanthanide complexes containing the cyclic peptide c(RGDfK) to visualize the α(v)β(3)-integrin-expressing tumor cells. Conjugation of c(RGDfK) with the macrocyclic bipyridine ligand had little effect on the fluorescence properties of the complex, indicating that the coordinated lanthanide ion was well isolated from the peptide. Bright luminescence images of α(v)β(3)-integrin-expressing U87-MG cells were successfully obtained by employing the probes.
authors: Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan. takeoit@scl.kyoto-u.ac.jp
authors: Takeo
authors: T
authors: Ito
authors: Masaki
authors: M
authors: Inoue
authors: Kanako
authors: K
authors: Akamatsu
authors: Eriko
authors: E
authors: Kusaka
authors: Kazuhito
authors: K
authors: Tanabe
authors: Sei-ichi
authors: S
authors: Nishimoto