title: Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
abstract: In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.
authors: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California, USA.
authors: Christopher A
authors: CA
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authors: Gary K
authors: GK
authors: Chen
authors: William J
authors: WJ
authors: Blot
authors: Sara S
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authors: Strom
authors: Sonja I
authors: SI
authors: Berndt
authors: Rick A
authors: RA
authors: Kittles
authors: Benjamin A
authors: BA
authors: Rybicki
authors: William B
authors: WB
authors: Isaacs
authors: Sue A
authors: SA
authors: Ingles
authors: Janet L
authors: JL
authors: Stanford
authors: W Ryan
authors: WR
authors: Diver
authors: John S
authors: JS
authors: Witte
authors: Ann W
authors: AW
authors: Hsing
authors: Barbara
authors: B
authors: Nemesure
authors: Timothy R
authors: TR
authors: Rebbeck
authors: Kathleen A
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authors: Cooney
authors: Jianfeng
authors: J
authors: Xu
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authors: AS
authors: Kibel
authors: Jennifer J
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authors: Hu
authors: Esther M
authors: EM
authors: John
authors: Serigne M
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authors: Stephen
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authors: Watya
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authors: Wang
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authors: Yeboah
authors: Yao
authors: Y
authors: Tettey
authors: Qiuyin
authors: Q
authors: Cai
authors: Suzanne
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authors: Kolb
authors: Elaine A
authors: EA
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authors: Edder R
authors: ER
authors: Duarte
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authors: Xia
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