title: Differential regulation of glucose-transporter expression in hematopoietic-cells by oncogenic transformation and cytokine stimulation.
abstract: Malignant transformation by the v-src oncogene and mitogenic stimulation by interleukin-3 (IL-3) both increased glucose transport into a hematopoietic cell line. These increases were additive and correlated with elevations in the level of GLUT1 mRNA. Glucose transport and GLUT1 mRNA were dependent on the presence of a functional v-src gene product in the absence of IL-3. Nuclear run-on analyses and mRNA turnover experiments demonstrated that GLUT1 gene transcription was enhanced by v-src while IL-3 stabilized GLUT1 mRNA. Introduction of retroviruses overexpressing GLUT1 into factor-dependent cells did not abrogate factor-dependency. Thus, GLUT1 induction is necessary but not sufficient for mitogenesis.
authors: M
authors: M
authors: White
authors: J
authors: J
authors: Devente
authors: P
authors: P
authors: Robbins
authors: D
authors: D
authors: Canupp
authors: M
authors: M
authors: Mayo
authors: L
authors: L
authors: Steelman
authors: J
authors: J
authors: McCubrey