title: Synthesis of novel steroidal 17α-triazolyl derivatives via Cu(I)-catalyzed azide-alkyne cycloaddition, and an evaluation of their cytotoxic activity in vitro.
abstract: Regioselective Cu(I)-catalyzed 1,3-dipolar cycloaddition of steroidal 17α-azides with different terminal alkynes afforded novel 1,4-disubstituted triazolyl derivatives in good yields in both the estrone and the androstane series. The antiproliferative activities of the structurally related triazoles were determined in vitro on three malignant human cell lines (HeLa, MCF7 and A431), with the microculture tetrazolium assay.
authors: Department of Organic Chemistry, University of Szeged, Dóm tér 8., H-6720 Szeged, Hungary. frank@chem.u-szeged.hu
authors: Éva
authors: É
authors: Frank
authors: Judit
authors: J
authors: Molnár
authors: István
authors: I
authors: Zupkó
authors: Zalán
authors: Z
authors: Kádár
authors: János
authors: J
authors: Wölfling