title: Soluble endothelial selectin in acute lung injury complicated by severe pneumonia.
abstract: BACKGROUND
  Pneumonia is still one of the most frequent causes of death in the elderly. Complication of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) by pneumonia makes patients very ill due to severe respiratory failure. Biomarkers that can discriminate the presence of complicating ALI/ARDS are required for early detection. The aim of this research was to investigate whether soluble endothelial selectin (sES) could be a biomarker for ALI.
  
  
  METHODS
  Serum sES levels were measured in 27 pneumonia patients, who were enrolled between April 2006 and September 2007. Among these patients, six had ALI or a condition that was clinically comparable to ALI (cALI). All patients who were enrolled were successfully treated and survived.
  
  
  RESULTS
  Circulating sES levels were elevated in pneumonia patients with ALI/cALI, and sES levels decreased following treatment of their pneumonia. Univariate and multivariate logistic regression analyses showed that sES was the only significant factor for identifying complicating ALI/cALI, independently of C-reactive protein (CRP) and lactate dehydrogenase (LDH). By receiver operating characteristic (ROC) curve analysis, the cut-off value for sES was 40.1 ng/mL, with a sensitivity of 0.8 and a specificity of 0.8.
  
  
  CONCLUSIONS
  sES may be a useful biomarker for discriminating complicating ALI/cALI in patients with severe pneumonia.
authors: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
authors: Daisuke
authors: D
authors: Osaka
authors: Yoko
authors: Y
authors: Shibata
authors: Kazunori
authors: K
authors: Kanouchi
authors: Michiko
authors: M
authors: Nishiwaki
authors: Tomomi
authors: T
authors: Kimura
authors: Hiroyuki
authors: H
authors: Kishi
authors: Shuichi
authors: S
authors: Abe
authors: Sumito
authors: S
authors: Inoue
authors: Yoshikane
authors: Y
authors: Tokairin
authors: Akira
authors: A
authors: Igarashi
authors: Keiko
authors: K
authors: Yamauchi
authors: Yasuko
authors: Y
authors: Aida
authors: Takako
authors: T
authors: Nemoto
authors: Keiko
authors: K
authors: Nunomiya
authors: Koji
authors: K
authors: Fukuzaki
authors: Isao
authors: I
authors: Kubota
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