title: Ondansetron (OND) vs granisetron (GRA) in the control of chemotherapy induced acute emesis.
abstract: We enrolled 118 chemonaive cancer patients (pts) to receive OND i.v. dl or GRA i.v. dl. Seventy of the 118 pts received moderately emetogenic (ME) chemotherapy (140 cycles), while 48 received highly emetogenic (HE) chemotherapy (93 cycles). Therapeutic success was obtained in 89% (OND) vs 94% (GRA) cycles of HE and in 96.8% (OND) vs 95.6% (GRA) cycles of ME. The main toxicities were headache (24%, OND; 23%, GRA); light-headedness (13%, OND; 18%, GRA); constipation (11%, OND; 6%, GRA). In conclusion, we think that OND and GRA are effective and the two drugs are equally active and toxic.
authors: UNIV PALERMO, INST MED CLIN 1, CHAIR MED ONCOL, I-90127 PALERMO, ITALY. UNIV PALERMO, BMT, DIV HAEMATOL, I-90127 PALERMO, ITALY. UNIV PALERMO, MED ONCOL SERV, I-90127 PALERMO, ITALY.
authors: V
authors: V
authors: Leonardi
authors: E
authors: E
authors: Iannito
authors: M
authors: M
authors: Meli
authors: S
authors: S
authors: Palmeri