title: Neuropeptides in the gonads: from evolution to pharmacology.
abstract: Vertebrate gonads are the sites of synthesis and binding of many peptides that were initially classified as neuropeptides. These gonadal neuropeptide systems are neither well understood in isolation, nor in their interactions with other neuropeptide systems. Further, our knowledge of the control of these gonadal neuropeptides by peripheral hormones that bind to the gonads, and which themselves are under regulation by true neuropeptide systems from the hypothalamus, is relatively meager. This review discusses the existence of a variety of neuropeptides and their receptors which have been discovered in vertebrate gonads, and the possible way in which such systems could have evolved. We then focus on two key neuropeptides for regulation of the hypothalamo-pituitary-gonadal axis: gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH). Comparative studies have provided us with a degree of understanding as to how a gonadal GnRH system might have evolved, and they have been responsible for the discovery of GnIH and its gonadal counterpart. We attempt to highlight what is known about these two key gonadal neuropeptides, how their actions differ from their hypothalamic counterparts, and how we might learn from comparative studies of them and other gonadal neuropeptides in terms of pharmacology, reproductive physiology and evolutionary biology.
authors: Laboratory of Reproductive Neuroendocrinology, Department of Integrative Biology, University of California at Berkeley Berkeley, CA, USA.
authors: Nicolette L
authors: NL
authors: McGuire
authors: George E
authors: GE
authors: Bentley
references: Gen Comp Endocrinol. 1997 Nov;108(2):327-39
references: 9356228
references: Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9636-41
references: 11493674
references: Endocrinology. 1990 Nov;127(5):2350-6
references: 2226321
references: Endocrinology. 2009 Jun;150(6):2799-804
references: 19131572
references: Peptides. 2004 Oct;25(10):1751-7
references: 15476942
references: Gen Comp Endocrinol. 2008 Mar 1;156(1):34-43
references: 18031743
references: J Neuroendocrinol. 2009 Mar;21(4):271-5
references: 19207818
references: Mol Cell Endocrinol. 1995 Feb 27;108(1-2):169-77
references: 7758831
references: Endocrinology. 2005 Aug;146(8):3401-8
references: 15908340
references: Biochem Biophys Res Commun. 2000 Aug 28;275(2):661-7
references: 10964719
references: Life Sci. 1998;63(4):255-63
references: 9698034
references: Cell Tissue Res. 1995 Aug;281(2):375-8
references: 7648631
references: J Med Primatol. 2003 Jun;32(3):170-7
references: 12823627
references: Regul Pept. 1997 Jun 18;70(2-3):149-60
references: 9272627
references: Gen Comp Endocrinol. 1985 Nov;60(2):154-61
references: 3905500
references: Endocrinology. 1995 Jan;136(1):172-9
references: 7828528
references: Science. 1984 Aug 10;225(4662):632-4
references: 6740329
references: Mol Cell Endocrinol. 1996 Mar 25;117(2):121-30
references: 8737371
references: Endocrinology. 1991 Nov;129(5):2787-9
references: 1935809
references: Endocrinology. 1986 Jun;118(6):2561-71
references: 3009164
references: Biol Reprod. 1995 Sep;53(3):620-6
references: 7578686
references: J Med Primatol. 2000 Dec;29(6):411-4
references: 11168832
references: Environ Health Perspect. 1993 Jul;101 Suppl 2:91-100
references: 8243411
references: Gen Comp Endocrinol. 2004 Aug;138(1):70-7
references: 15242753
references: Gen Comp Endocrinol. 2010 May 1;166(3):565-72
references: 20074575
references: Mol Reprod Dev. 2002 Oct;63(2):151-60
references: 12203824
references: Can J Physiol Pharmacol. 2000 Dec;78(12):1003-12
references: 11149378
references: Mol Cell Endocrinol. 2003 Apr 28;202(1-2):155-64
references: 12770745
references: Biochem Biophys Res Commun. 1980 Aug 14;95(3):993-1000
references: 6774721
references: J Exp Zool. 1996 Jan 1;274(1):33-40
references: 8583206
references: Endocrinology. 1998 Feb;139(2):651-8
references: 9449637
references: J Endocrinol. 2004 Jul;182(1):33-42
references: 15225129
references: J Endocrinol. 1998 Oct;159(1):179-89
references: 9795356
references: Peptides. 2006 Dec;27(12):3029-38
references: 16920225
references: Biol Reprod. 1981 May;24(4):747-59
references: 6264981
references: Biochem Biophys Res Commun. 1992 Mar 16;183(2):390-5
references: 1550548
references: J Exp Zool. 1992 Jan 1;261(1):34-9
references: 1729384
references: J Endocrinol. 2006 Oct;191(1):287-99
references: 17065411
references: Gen Comp Endocrinol. 2010 Jun 1;167(2):331-7
references: 20350548
references: J Mol Endocrinol. 2007 Feb;38(1-2):289-304
references: 17293447
references: Horm Behav. 2006 Apr;49(4):550-5
references: 16460739
references: Reproduction. 2007 May;133(5):969-81
references: 17616726
references: N Engl J Med. 1977 Nov 24;297(21):1141-5
references: 411032
references: J Urol. 1995 Nov;154(5):1958-61
references: 7563392
references: Biochem Biophys Res Commun. 1982 Jun 30;106(4):1210-7
references: 7052087
references: Peptides. 2000 Sep;21(9):1383-8
references: 11072126
references: Peptides. 2008 Oct;29(10):1672-8
references: 18586058
references: Gen Comp Endocrinol. 1982 Sep;48(1):117-22
references: 6182053
references: Peptides. 2006 May;27(5):1121-9
references: 16517011
references: Asian J Androl. 2006 Jul;8(4):443-9
references: 16763720
references: Endocrinology. 1980 Jun;106(6):1697-705
references: 6245849
references: J Neuroendocrinol. 2009 Mar;21(4):276-81
references: 19210295
references: Endocrinology. 2002 Mar;143(3):737-43
references: 11861490
references: Endocrinology. 2005 Mar;146(3):1588-96
references: 15564332
references: Biol Reprod. 1988 Mar;38(2):296-303
references: 2451937
references: Peptides. 1999;20(10):1247-62
references: 10573298
references: Front Neuroendocrinol. 2009 Aug;30(3):371-8
references: 19362107
references: Mol Reprod Dev. 2008 Oct;75(10):1567-77
references: 18363198
references: Gen Comp Endocrinol. 1996 Mar;101(3):282-96
references: 8729938
references: Brain Res. 2000 Aug 11;873(2):306-9
references: 10930560
references: J Neuroendocrinol. 2001 Jan;13(1):37-49
references: 11123514
references: Mol Cell Endocrinol. 1981 Jan;21(1):43-9
references: 6781950
references: J Androl. 2005 Mar-Apr;26(2):222-34
references: 15713828
references: Mol Cell Endocrinol. 1998 May 25;140(1-2):175-8
references: 9722187
references: Endocrinology. 2009 Dec;150(12):5549-56
references: 19808777
references: Gen Comp Endocrinol. 2008 Jul;157(3):266-74
references: 18486132
references: Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2343-8
references: 10688887
references: Endocrinology. 1998 Apr;139(4):2015-24
references: 9528989
references: Endocrinology. 1981 Mar;108(3):812-9
references: 6780324
references: Science. 1981 Sep 11;213(4513):1263-4
references: 7022653
references: Biochem Biophys Res Commun. 1994 May 16;200(3):1359-66
references: 8185587
references: Nat Cell Biol. 2000 Oct;2(10):703-8
references: 11025660
references: Physiol Rev. 1972 Jan;52(1):198-236
references: 4621362
references: Acta Endocrinol (Copenh). 1987 Jul;115(3):373-7
references: 3303786
references: Endocrinology. 2006 Oct;147(10):4852-62
references: 16825322
references: J Neuroendocrinol. 2004 Dec;16(12):999-1006
references: 15667455
references: Mol Cell Endocrinol. 2000 Dec 22;170(1-2):143-51
references: 11162898
references: Mol Reprod Dev. 2009 May;76(5):444-52
references: 18937338
references: Nature. 1979 Nov 1;282(5734):90-2
references: 228197
references: Mol Cell Endocrinol. 2000 Feb 25;160(1-2):75-88
references: 10715541
references: Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10461-4
references: 8816823
references: Gen Comp Endocrinol. 2007 Aug-Sep;153(1-3):365-70
references: 17141777
references: J Endocrinol. 2005 Jan;184(1):257-66
references: 15642802
references: Mol Cell Endocrinol. 1999 Nov 25;157(1-2):41-54
references: 10619396
references: J Exp Zool A Comp Exp Biol. 2006 Sep 1;305(9):807-14
references: 16902963
references: Gen Comp Endocrinol. 2003 Apr;131(2):192-201
references: 12679096
references: Endocrinology. 2010 Feb;151(2):617-27
references: 20051487
references: Nature. 1979 Sep 6;281(5726):66-7
references: 233123
references: Am J Physiol Endocrinol Metab. 2007 May;292(5):E1456-64
references: 17468395
references: J Clin Endocrinol Metab. 1999 Jun;84(6):1768-74
references: 10372662
references: Gen Comp Endocrinol. 1995 Jul;99(1):85-99
references: 7657161
references: Horm Behav. 2007 Jan;51(1):126-34
references: 17049519
references: Regul Pept. 1984 Mar;8(2):141-6
references: 6729151
references: Endocrinology. 2010 Apr;151(4):1902-13
references: 20160130
references: Endocrinology. 1994 Nov;135(5):1740-6
references: 7956897
references: Peptides. 1997;18(9):1411-4
references: 9392844
references: Comp Biochem Physiol B Biochem Mol Biol. 2001 Jun;129(2-3):483-7
references: 11399483
references: Mol Cell Endocrinol. 2006 Jun 27;252(1-2):120-5
references: 16672174
references: Endocr Rev. 1981 Fall;2(4):437-61
references: 6273147
references: Horm Behav. 2007 Jan;51(1):171-80
references: 17113584
references: Environ Sci Technol. 2009 Apr 1;43(7):2614-9
references: 19452925
references: Gastroenterology. 1995 Oct;109(4):1105-12
references: 7557075
references: PLoS One. 2009 Dec 22;4(12):e8400
references: 20027225
references: Biochim Biophys Acta. 1999 Jul 8;1450(3):452-9
references: 10395956
references: Neuroendocrinology. 2009;90(4):416-32
references: 19657181
references: Gen Comp Endocrinol. 2009 Apr;161(2):252-61
references: 19523382
references: Endocrinology. 2001 Jan;142(1):182-92
references: 11145581
references: Science. 1971 Sep 10;173(4001):1036-8
references: 4938639
references: Endocrinology. 2002 Dec;143(12):4673-82
references: 12446595
references: Proc Soc Exp Biol Med. 1995 Sep;209(4):387-91
references: 7638247
references: J Clin Endocrinol Metab. 2002 Mar;87(3):1427-30
references: 11889221
references: Biol Reprod. 1971 Oct;5(2):111-4
references: 5000818
references: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2410-5
references: 16467147
references: Gen Comp Endocrinol. 1999 Jan;113(1):112-20
references: 9882550
references: Reproduction. 2008 Feb;135(2):267-74
references: 18239054
references: Endocrinology. 1986 Aug;119(2):731-6
references: 3089762
references: Gynecol Obstet Invest. 2000;49(1):52-6
references: 10629374
references: Endocrinology. 1983 May;112(5):1653-61
references: 6299703
references: Endocrinology. 2006 Mar;147(3):1187-94
references: 16293662
references: Endocr Rev. 1996 Apr;17(2):121-55
references: 8706629
references: J Steroid Biochem. 1985 Nov;23(5B):743-55
references: 3001417
references: J Natl Cancer Inst. 1996 Aug 21;88(16):1118-26
references: 8757191
references: Growth Regul. 1992 Dec;2(4):175-91
references: 1290954
references: Fertil Steril. 1984 Dec;42(6):906-14
references: 6389185
references: Life Sci. 1980 Dec 1;27(22):2125-32
references: 6259472