title: Characterization of MHC class I and II genes in a subantarctic seabird, the blue petrel, Halobaena caerulea (Procellariiformes).
abstract: The great polymorphism observed in the major histocompatibility complex (MHC) genes is thought to be maintained by pathogen-mediated selection possibly combined with MHC-disassortative mating, guided by MHC-determined olfactory cues. Here, we partly characterize the MHC class I and II B of the blue petrel, Halobaena caerulea (Procellariiformes), a bird with significant olfactory abilities that lives under presumably low pathogen burdens in Subantarctica. Blue petrels are long-lived, monogamous birds which suggest the necessity of an accurate mate choice process. The species is ancestral to songbirds (Passeriformes; many MHC loci), although not to gamefowls (Galliformes; few MHC loci). Considering the phylogenetic relationships and the low subantarctic pathogen burden, we expected few rather than many MHC loci in the blue petrel. However, when we analysed partial MHC class I and class II B cDNA and gDNA sequences we found evidence for as many as at least eight MHC class I loci and at least two class II B loci. These class I and II B sequences showed classical MHC characteristics, e.g. high nucleotide diversity, especially in putative peptide-binding regions where signatures of positive selection was detected. Trans-species polymorphism was found between MHC class II B sequences of the blue petrel and those of thin-billed prion, Pachyptila belcheri, two species that diverged ∼25 MYA. The observed MHC allele richness in the blue petrel may well serve as a basis for mate choice, especially since olfactory discrimination of MHC types may be possible in this species.
authors: Behavioral Ecology Group, CEFE-CNRS, 1919 Route de Mende, 34293, Montpellier Cedex 5, France. maria.strandh@biol.lu.se
authors: Maria
authors: M
authors: Strandh
authors: Mimi
authors: M
authors: Lannefors
authors: Francesco
authors: F
authors: Bonadonna
authors: Helena
authors: H
authors: Westerdahl
references: J Mol Evol. 2009 Mar;68(3):279-91
references: 19209378
references: Nature. 1993 Jul 1;364(6432):33-9
references: 8316295
references: Genetics. 2003 Jul;164(3):1229-36
references: 12871927
references: Heredity (Edinb). 2004 Jun;92(6):534-42
references: 15162116
references: BMC Biol. 2010 Apr 01;8:29
references: 20359332
references: J Immunol. 2004 Jun 1;172(11):6751-63
references: 15153492
references: Anim Behav. 1998 Aug;56(2):319-327
references: 9787022
references: Mol Ecol. 2000 Aug;9(8):1013-27
references: 10964221
references: J Immunol. 2005 Nov 15;175(10):6702-12
references: 16272326
references: Behav Genet. 1989 Sep;19(5):659-74
references: 2508616
references: Nature. 1999 Oct 28;401(6756):923-5
references: 10553909
references: J Mol Evol. 1980 Dec;16(2):111-20
references: 7463489
references: Microbes Infect. 2000 Sep;2(11):1335-41
references: 11018450
references: Immunogenetics. 2006 Jun;58(5-6):433-42
references: 16738940
references: Mol Ecol. 2004 Aug;13(8):2465-70
references: 15245418
references: Immunogenetics. 2000 Nov;52(1-2):92-100
references: 11132162
references: Science. 2008 Jun 27;320(5884):1763-8
references: 18583609
references: Mol Ecol. 2004 Dec;13(12):3821-8
references: 15548294
references: Physiol Behav. 1987;40(1):65-73
references: 3615656
references: Evolution. 1996 Oct;50(5):2066-2072
references: 28565588
references: Nucleic Acids Res. 2003 Jul 1;31(13):3497-500
references: 12824352
references: Mol Biol Evol. 1987 Jul;4(4):406-25
references: 3447015
references: Proc Biol Sci. 2005 Apr 7;272(1564):759-67
references: 15870038
references: Science. 2004 Oct 29;306(5697):835
references: 15514149
references: Mol Biol Evol. 2007 Aug;24(8):1586-91
references: 17483113
references: Mol Ecol. 2003 Dec;12(12):3523-9
references: 14629367
references: Trends Ecol Evol. 2004 Oct;19(10):554-9
references: 16701321
references: Immunogenetics. 2004 Mar;55(12):855-65
references: 14963619
references: Psychoneuroendocrinology. 2009 May;34(4):497-512
references: 19054623
references: Immunogenetics. 2009 May;61(5):341-52
references: 19319519
references: Heredity (Edinb). 1998 Aug;81 ( Pt 2):127-33
references: 9750260
references: Immunogenetics. 1999 Mar;49(3):158-70
references: 9914330
references: J Evol Biol. 2003 May;16(3):363-77
references: 14635837
references: J Exp Med. 1979 Oct 1;150(4):755-60
references: 512584
references: PLoS Genet. 2008 Sep 12;4(9):e1000184
references: 18787687
references: Am Nat. 2002 Dec;160 Suppl 6:S225-37
references: 18707479
references: Mol Biol Evol. 1986 Sep;3(5):418-26
references: 3444411
references: Mol Biol Evol. 2005 Apr;22(4):1107-18
references: 15689528
references: Mol Ecol. 2003 Nov;12(11):3077-83
references: 14629387
references: Adv Immunol. 1998;69:411-36
references: 9646849
references: Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1434-9
references: 16432226
references: Vet Immunol Immunopathol. 2002 Mar;85(3-4):129-35
references: 11943314
references: Mol Biol Evol. 1998 Oct;15(10):1360-71
references: 9787440
references: Lancet. 1975 Jun 28;1(7922):1406-9
references: 49564
references: Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7
references: 271968
references: J Hered. 2010 Jul-Aug;101(4):448-60
references: 20200139
references: Mol Biol Evol. 2007 Aug;24(8):1596-9
references: 17488738
references: J Exp Med. 1976 Nov 2;144(5):1324-35
references: 1032893
references: Chem Senses. 2010 May;35(4):309-21
references: 20190009
references: Evolution. 1985 Jul;39(4):783-791
references: 28561359
references: Nucleic Acids Res. 2008 Jan;36(Database issue):D25-30
references: 18073190
references: Am Nat. 2003 Apr;161(4):657-71
references: 12778891
references: Immunol Rev. 1995 Feb;143:63-88
references: 7558083
references: Immunogenetics. 2011 Apr;63(4):223-33
references: 21221966
references: J Exp Biol. 2006 Jun;209(Pt 11):2165-9
references: 16709918
references: Immunogenetics. 1990;31(4):217-9
references: 2329006
references: Proc Biol Sci. 2006 May 7;273(1590):1111-6
references: 16600889
references: Proc Biol Sci. 2009 Mar 22;276(1659):1083-92
references: 19129124