title: A clinical perspective: anti tau's treatment in Alzheimer's disease.
abstract: Alzheimer΄s Disease (AD) physiopathology is not yet totally established. Nevertheless it is known that a metabolism dysfunction of the amyloid beta precursor protein (APP) and the abnormal tau protein phosphorylation lead to the formation of neuritic plaques and neurofibrillary tangles, respectively. These events finally drive to the clinical expression of dementia. Formally approved during the past decade, treatments for AD are lacking of an updating, being essentially symptomatic. Anticholinesterase agents have failed in providing a substantial improvement in the mental health condition of AD patients. On the other hand, antiamyloid strategies, have failed in their efficacy or security on their last development phases. In this context, tau represents a potential therapeutic target, by the action of drugs that diminish its aggregation, or acting by altering its phosphorylation or filaments formation. There is also anti-tau miscellaneous strategies such as normal microtubule-stabilizing agents. Thus, it might be possible that in a near future the neurodegenerative process could be stopped.
authors: Cognitive Neurology Unit, Department of Neurology, Hospital del Salvador & Department of Geriatrics, Clinical Hospital, University of Chile, Chile. pfuentes@redclinicauchile.cl
authors: P
authors: P
authors: Fuentes
authors: J
authors: J
authors: Catalan