title: Molecular SPECT Imaging: An Overview.
abstract: Molecular imaging has witnessed a tremendous change over the last decade. Growing interest and emphasis are placed on this specialized technology represented by developing new scanners, pharmaceutical drugs, diagnostic agents, new therapeutic regimens, and ultimately, significant improvement of patient health care. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) have their signature on paving the way to molecular diagnostics and personalized medicine. The former will be the topic of the current paper where the authors address the current position of the molecular SPECT imaging among other imaging techniques, describing strengths and weaknesses, differences between SPECT and PET, and focusing on different SPECT designs and detection systems. Radiopharmaceutical compounds of clinical as well-preclinical interest have also been reviewed. Moreover, the last section covers several application, of μSPECT imaging in many areas of disease detection and diagnosis.
authors: Biological Imaging Centre, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
authors: Magdy M
authors: MM
authors: Khalil
authors: Jordi L
authors: JL
authors: Tremoleda
authors: Tamer B
authors: TB
authors: Bayomy
authors: Willy
authors: W
authors: Gsell
references: Nucl Med Biol. 2003 Nov;30(8):889-95
references: 14698793
references: NeuroRx. 2005 Apr;2(2):237-49
references: 15897948
references: Phys Med Biol. 2009 May 7;54(9):2635-49
references: 19351981
references: J Nucl Med. 2005 May;46(5):816-22
references: 15872356
references: Phys Med Biol. 2005 Nov 21;50(22):R45-61
references: 16264248
references: J Nucl Med. 2006 May;47(5):868-76
references: 16644758
references: Mol Imaging Biol. 2003 Sep-Oct;5(5):304-11
references: 14630510
references: Circulation. 2004 Nov 23;110(21):3378-83
references: 15557385
references: J Nucl Med. 2008 Oct;49(10):1651-63
references: 18794275
references: J Nucl Med. 2009 Jul;50(7):1147-52
references: 19525450
references: Arch Toxicol. 2005 May;79(5):268-76
references: 15902424
references: Eur J Nucl Med Mol Imaging. 2005 Feb;32(2):211-20
references: 15372208
references: Eur J Nucl Med. 2001 Mar;28(3):266-72
references: 11315592
references: Nature. 1975 Aug 7;256(5517):495-7
references: 1172191
references: Clin Nucl Med. 2008 Jan;33(1):46-8
references: 18097260
references: J Radiol. 2008 Mar;89(3 Pt 2):438-47; quiz 448
references: 18408643
references: J Nucl Med. 2001 Sep;42(9):1368-74
references: 11535727
references: Eur J Nucl Med Mol Imaging. 2004 Jan;31(1):44-51
references: 14551751
references: Neurochem Int. 2008 Feb;52(3):352-62
references: 17904694
references: J Nucl Med. 2009 May;50(5):667-70
references: 19372476
references: J Nucl Med. 1990 Mar;31(3):281-6
references: 2155314
references: Clin Radiol. 2010 Jul;65(7):500-16
references: 20541650
references: J Nucl Med. 2004 Oct;45(10):1759-65
references: 15471846
references: J Nucl Med. 1991 May;32(5):819-24
references: 2022989
references: J Nucl Med. 2008 Jun;49 Suppl 2:129S-48S
references: 18523070
references: Nucl Med Biol. 1995 Oct;22(7):875-85
references: 8547885
references: J Nucl Med. 2002 Jul;43(7):933-9
references: 12097466
references: Thromb Res. 1994 Sep 1;75(5):491-501
references: 7992250
references: J Nucl Med. 2000 Apr;41(4):661-81
references: 10768568
references: Curr Cardiol Rep. 2010 Jan;12(1):51-8
references: 20425184
references: Mol Pharm. 2006 Nov-Dec;3(6):717-25
references: 17140259
references: J Cell Biochem Suppl. 2002;39:116-24
references: 12552611
references: J Clin Invest. 2004 Jun;113(12):1684-91
references: 15199403
references: J Am Coll Cardiol. 2008 Nov 11;52(20):1652-60
references: 18992656
references: J Org Chem. 2003 Jan 24;68(2):512-8
references: 12530878
references: J Nucl Med. 2004 Oct;45(10):1688-93
references: 15471834
references: Nucl Med Biol. 2006 Feb;33(2):217-26
references: 16546676
references: J Nucl Med. 2004 Jul;45(7):1251-9
references: 15235074
references: J Magn Reson Imaging. 2002 Oct;16(4):352-61
references: 12353251
references: Eur J Nucl Med. 2000 Jul;27(7):867-9
references: 10952500
references: Med Phys. 2006 May;33(5):1259-68
references: 16752560
references: J Nucl Med. 1991 Jun;32(6):1225-9
references: 2045937
references: Nucl Med Commun. 2006 Jul;27(7):595-6
references: 16794521
references: J Nucl Med. 2007 Jan;48(1):115-21
references: 17204707
references: Circulation. 2003 Oct 28;108(17):2127-33
references: 14530205
references: Anticancer Drugs. 2006 Jul;17(6):601-8
references: 16917205
references: Phys Med Biol. 2008 May 7;53(9):2233-52
references: 18401059
references: J Nucl Med. 2009 Apr;50(4):599-605
references: 19289425
references: Clin Cancer Res. 2005 Jun 1;11(11):4022-8
references: 15930336
references: Mol Imaging Biol. 2009 May-Jun;11(3):195-203
references: 19048346
references: Clin Nucl Med. 1995 Nov;20(11):973-5
references: 8565377
references: Ann Oncol. 2006 Dec;17(12):1733-42
references: 16801334
references: Eur J Nucl Med Mol Imaging. 2004 Aug;31(8):1136-45
references: 15007564
references: Methods. 2009 Jun;48(2):83-91
references: 19328232
references: J Nucl Med. 1998 Nov;39(11):1928-36
references: 9829585
references: Prostate Cancer Prostatic Dis. 2002;5(2):132-5
references: 12497003
references: J Nucl Med. 2005 Jun;46(6):1005-11
references: 15937312
references: Eur J Nucl Med Mol Imaging. 2007 Jun;34 Suppl 1:S27-33
references: 17464505
references: Semin Nucl Med. 1990 Jan;20(1):80-91
references: 2404343
references: Clin Nucl Med. 2003 Apr;28(4):267-76
references: 12642703
references: J Nucl Med. 2009 Apr;50(4):635-43
references: 19339672
references: Int J Pharm. 2006 Jun 19;316(1-2):162-9
references: 16580161
references: Nucl Med Commun. 2003 Nov;24(11):1149-54
references: 14569169
references: J Nucl Med. 1999 Jan;40(1):184-91
references: 9935075
references: Circ Res. 2000 Jun 9;86(11):1107-13
references: 10850960
references: J Nucl Med. 2002 Aug;43(8):1072-83
references: 12163634
references: Cell. 2000 Jan 7;100(1):57-70
references: 10647931
references: Q J Nucl Med Mol Imaging. 2009 Aug;53(4):374-81
references: 19834446
references: J Nucl Med. 2001 Sep;42(9):1418-23
references: 11535735
references: Eur J Nucl Med Mol Imaging. 2005 Nov;32(11):1305-10
references: 16003562
references: Eur J Nucl Med Mol Imaging. 2002 Nov;29(11):1507-15
references: 12537007
references: Eur J Nucl Med Mol Imaging. 2009 Mar;36 Suppl 1:S3-9
references: 19104804
references: Cancer. 1993 Dec 1;72(11 Suppl):3453-62
references: 8242578
references: J Clin Oncol. 1996 Aug;14(8):2295-305
references: 8708720
references: Semin Nucl Med. 2001 Oct;31(4):321-9
references: 11710774
references: J Nucl Med. 2006 May;47(5):877-84
references: 16644759
references: Methods. 2010 Jan;50(1):2-13
references: 19706326
references: Circulation. 2003 Dec 23;108(25):3134-9
references: 14676140
references: Chest. 2004 Feb;125(2):494-501
references: 14769730
references: Cell Res. 2009 Mar;19(3):370-9
references: 19114988
references: Eur J Nucl Med Mol Imaging. 2005 Aug;32(8):925-31
references: 15841374
references: Nucl Med Commun. 1994 Sep;15(9):718-22
references: 7816385