title: Nonionic Block Copolypeptide Micelles Containing a Hydrophobic racemic-Leucine Core.
abstract: Block copolymer micelles have been used extensively as carriers for therapeutic drugs and diagnostic molecules. Here, we report the synthesis of nonionic, block copolypeptides, K(P) (x)(rac-L)(y), which have a "reversed" rod-coil structure composed of a hydrophilic, rod-like, α-helical segment attached to a disordered, racemic hydrophobic segment. The self assembly of these block copolypeptides in water was studied, and their compositions were optimized to identify a sample, K(P) (100)(rac-L)(10), which is able to form well defined micelles that are very stable against dilution, high temperatures, and various media. Micelle structure was determined using a combination of electron microscopy and dynamic light scattering measurements. The potential of these micelles as drug delivery carriers was evaluated by encapsulation of the anticancer drug camptothecin. The drug containing micelles were found to be stable.
authors: Bioengineering Department,University of California, Los Angeles, CA 90095.
authors: Jarrod A
authors: JA
authors: Hanson
authors: Zhibo
authors: Z
authors: Li
authors: Timothy J
authors: TJ
authors: Deming
references: J Control Release. 2000 Feb 14;64(1-3):143-53
references: 10640653
references: J Control Release. 1998 Feb 12;51(2-3):241-8
references: 9685922
references: Nat Mater. 2004 Apr;3(4):244-8
references: 15034560
references: J Control Release. 2005 Dec 5;109(1-3):169-88
references: 16289422
references: Science. 1995 Jun 23;268(5218):1728-31
references: 17834990
references: Nature. 2008 Sep 4;455(7209):85-8
references: 18769436
references: J Control Release. 1998 Feb 12;51(2-3):169-78
references: 9685914
references: Pharm Res. 2007 Jan;24(1):1-16
references: 17109211
references: Biochemistry. 2000 Sep 26;39(38):11657-66
references: 10995233