title: Slowly progressive aphemia: a neuropsychological, conventional, and functional MRI study.
abstract: Slowly progressive aphemia (SPA) is a rare focal degenerative disorder characterized by severe dysarthria, frequent orofacial apraxia, dysprosody, phonetic and phonemic errors without global cognitive deterioration for many years. This condition is caused by a degeneration of anterior frontal lobe regions, mainly of the left frontal operculum. We report a case of SPA with a course of 8 years, evaluated by repeated neuropsychological, conventional, and functional MRI examinations. In our case, neuropsychological examinations showed a progressive impairment of speech articulation including dysprosody, phonetic and phonemic errors, and slight writing errors. No global cognitive deterioration was detected and the patient is still completely autonomous. Morphological and functional investigations showed, respectively, a progressive atrophy and progressive impairment of the left frontal region, confirming the role of the opercular region in determining this rare syndrome. During verbal task generation as the cortical activation of this region gradually decreased, the language articulation worsened.
authors: Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123 Bologna, Italy. roberto.gallassi@unibo.it
authors: R
authors: R
authors: Gallassi
authors: L
authors: L
authors: Sambati
authors: R
authors: R
authors: Poda
authors: F
authors: F
authors: Oppi
authors: M
authors: M
authors: Stanzani Maserati
authors: D
authors: D
authors: Cevolani
authors: R
authors: R
authors: Agati
authors: R
authors: R
authors: Lodi
references: J Neurol Neurosurg Psychiatry. 1993 Aug;56(8):923-4
references: 8350114
references: Eur Neurol. 2006;55(4):225-6
references: 16778439
references: Psychiatry Res. 2004 Jan 15;130(1):97-107
references: 14972372
references: Radiology. 2008 Jan;246(1):214-21
references: 17991785
references: Acta Psychiatr Scand. 1986 Jul;74(1):62-7
references: 3766185
references: Ann Neurol. 2009 Mar;65(3):357
references: 19334080
references: Neurology. 1998 Dec;51(6):1546-54
references: 9855500
references: J Neurol Neurosurg Psychiatry. 1991 Apr;54(4):351-7
references: 2056322
references: Eur Neurol. 1996;36(6):378-84
references: 8954307
references: Neurocase. 2003 Jun;9(3):213-20
references: 12925927
references: Neurocase. 2005 Jun;11(3):234-41
references: 16006336
references: J Neurol Sci. 1998 Aug 14;159(2):156-61
references: 9741400
references: J Neurol Sci. 1996 Dec;144(1-2):44-58
references: 8994103
references: Brain. 2008 Oct;131(Pt 10):2690-700
references: 18819991
references: Neuroimage. 2009 Oct 1;47(4):1558-67
references: 19501654
references: Semin Speech Lang. 2002 Nov;23(4):267-80
references: 12461726
references: Arch Neurol. 1983 Nov;40(12):720-7
references: 6625983
references: Ann Neurol. 2008 Jul;64(1):4-14
references: 18668533
references: Brain. 2006 Jun;129(Pt 6):1385-98
references: 16613895
references: Neurologia. 2000 May;15(5):208-10
references: 10850122
references: Curr Opin Neurol. 2008 Dec;21(6):688-92
references: 18989114
references: Arch Gerontol Geriatr. 2002 Mar-Apr;34(2):123-34
references: 14764316
references: Neurocase. 2005 Dec;11(6):427-32
references: 16393756
references: Neurology. 2008 Oct 14;71(16):1227-34
references: 18633132
references: Neurocase. 2008;14(2):162-8
references: 18569741
references: Neurology. 1997 Nov;49(5):1298-306
references: 9371912
references: Psychiatry Clin Neurosci. 2002 Feb;56(1):111-5
references: 11929580