title: Association of interleukin-6 in women with persistence of DNA-HPV: a nested case-control study.
abstract: OBJECTIVE
  To identify the role of Interleukin-6, IL-10 and their epidemiological association in women with persistence of DNA-HPV.
  
  
  METHODS
  A nested case-control study within a longitudinal cohort study. Cervical specimens and blood samples were collected at enrolment from asymptomatic women who looked for a service of public health in a district of Porto Alegre, Brazil. A logistic regression analysis was performed with 95% confidence intervals. The outcome was the persistence of DNA-HPV infection.
  
  
  RESULTS
  The analysis showed that the age of the first intercourse below 20 years old (OR = 19.65, IC 95% 2.43-68.85), four or more sexual partners during lifetime (OR = 5.67, IC 95% 1.28-24.99), women with a previous altered Pap smear (OR = 10.17, IC 95% 1.80-57.33), marital status (OR = 12.94, IC 95% 2.43-68.85) and IL6 ≤ 3.106 pg/ml were associated with persistence of HPV infection. IL-10 were not associated with the HPV persistence.
  
  
  CONCLUSIONS
  The present study suggests that IL-6 levels may be a marker of HPV DNA persistence, although further investigation is necessary.
authors: Laboratory of Epidemiology and National Institute for Translational Medicine, Postgraduate Program in Health Sciences, University of the Extreme-South Catarinense, Criciuma, Brazil. mir@unesc.net
authors: Maria Inês
authors: MI
authors: Rosa
authors: Matheus Villas
authors: MV
authors: Moraes
authors: Francieli
authors: F
authors: Vuolo
authors: Fabricia
authors: F
authors: Petronilho
authors: Mary Clarisse
authors: MC
authors: Bozzetti
authors: Lidia Rosi
authors: LR
authors: Medeiros
authors: Cristine Nascente
authors: CN
authors: Igansi
authors: Fábio Rosa
authors: FR
authors: Silva
authors: Felipe
authors: F
authors: Dal-Pizzol
authors: Daniela Dorneles
authors: DD
authors: Rosa