title: Oligodendrocytes as regulators of neuronal networks during early postnatal development.
abstract: Oligodendrocytes are the glial cells responsible for myelin formation. Myelination occurs during the first postnatal weeks and, in rodents, is completed during the third week after birth. Myelin ensures the fast conduction of the nerve impulse; in the adult, myelin proteins have an inhibitory role on axon growth and regeneration after injury. During brain development, oligodendrocytes precursors originating in multiple locations along the antero-posterior axis actively proliferate and migrate to colonize the whole brain. Whether the initial interactions between oligodendrocytes and neurons might play a functional role before the onset of myelination is still not completely elucidated. In this article, we addressed this question by transgenically targeted ablation of proliferating oligodendrocytes during cerebellum development. Interestingly, we show that depletion of oligodendrocytes at postnatal day 1 (P1) profoundly affects the establishment of cerebellar circuitries. We observed an impressive deregulation in the expression of molecules involved in axon growth, guidance and synaptic plasticity. These effects were accompanied by an outstanding increase of neurofilament staining observed 4 hours after the beginning of the ablation protocol, likely dependent from sprouting of cerebellar fibers. Oligodendrocyte ablation modifies localization and function of ionotropic glutamate receptors in Purkinje neurons. These results show a novel oligodendrocyte function expressed during early postnatal brain development, where these cells participate in the formation of cerebellar circuitries, and influence its development.
authors: Department of Microbiology and Molecular Genetics and U904 INSERM/UCI, University of California Irvine, Irvine, California, United States of America.
authors: Sandrine
authors: S
authors: Doretto
authors: Monica
authors: M
authors: Malerba
authors: Maria
authors: M
authors: Ramos
authors: Taruna
authors: T
authors: Ikrar
authors: Chisato
authors: C
authors: Kinoshita
authors: Claudia
authors: C
authors: De Mei
authors: Emanuele
authors: E
authors: Tirotta
authors: Xiangmin
authors: X
authors: Xu
authors: Emiliana
authors: E
authors: Borrelli
references: Nature. 1989 Jun 15;339(6225):538-41
references: 2733785
references: Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9954-9
references: 11493687
references: J Neurosci. 1999 Jun 1;19(11):4407-20
references: 10341242
references: J Neurosci. 2000 Jun 1;20(11):4129-37
references: 10818148
references: J Neurosci. 2000 Oct 15;20(20):7698-705
references: 11027231
references: J Neurosci. 1994 Feb;14(2):667-96
references: 8301357
references: Curr Biol. 2009 Jul 14;19(13):R504-7
references: 19602408
references: Nat Rev Neurosci. 2006 Jan;7(1):11-8
references: 16371946
references: Proc Natl Acad Sci U S A. 1988 Oct;85(20):7572-6
references: 2845412
references: Brain Res Dev Brain Res. 1993 Dec 17;76(2):207-20
references: 8149587
references: J Neurosci Res. 1981;6(3):303-13
references: 6170761
references: Science. 2005 Dec 16;310(5755):1813-7
references: 16293723
references: Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15724-9
references: 9861037
references: Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5597-602
references: 18375768
references: Trends Neurosci. 2008 Feb;31(2):82-9
references: 18201773
references: J Neurosci. 2004 Mar 24;24(12):3002-12
references: 15044539
references: J Cell Biol. 2000 Jun 26;149(7):1443-54
references: 10871284
references: Exp Cell Res. 2007 Aug 1;313(13):2946-57
references: 17544395
references: Trends Neurosci. 2008 May;31(5):215-20
references: 18395807
references: Neuron. 2005 Jun 2;46(5):773-85
references: 15924863
references: J Comp Neurol. 2010 Feb 1;518(3):389-404
references: 19950390
references: Nat Neurosci. 2001 Jan;4(1):38-43
references: 11135643
references: Semin Perinatol. 2004 Dec;28(6):371-8
references: 15693393
references: Neuron. 2002 Jul 18;35(2):283-90
references: 12160746
references: Neuroscience. 1989;32(1):79-98
references: 2586753
references: Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):325-30
references: 14694200
references: Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19553-8
references: 18048342
references: Development. 2001 Dec;128(23):4881-90
references: 11731467
references: Eur J Neurosci. 2006 May;23(9):2247-54
references: 16706833
references: Cell. 1995 Feb 10;80(3):445-52
references: 7859286
references: Nature. 1994 Mar 24;368(6469):335-9
references: 7907398
references: Nature. 2010 Nov 11;468(7321):223-31
references: 21068831
references: Science. 1992 Jun 26;256(5065):1823-5
references: 1352066
references: Nature. 2009 Feb 5;457(7230):675-7
references: 19194443
references: Development. 2003 Oct;130(19):4709-18
references: 12925596
references: Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1593-610
references: 16939977
references: EMBO J. 2001 Aug 15;20(16):4332-6
references: 11500359
references: Development. 2000 Apr;127(7):1359-72
references: 10704383
references: J Neurosci. 1999 Jun 1;19(11):4437-48
references: 10341245
references: J Comp Neurol. 1994 May 22;343(4):513-9
references: 7518474
references: Eur J Neurosci. 2002 Jun;15(12):1976-82
references: 12099903
references: Neuropharmacology. 1998 Oct-Nov;37(10-11):1369-80
references: 9849672
references: J Neurosci. 2009 Jan 7;29(1):70-85
references: 19129386
references: J Biol Chem. 2010 Aug 6;285(32):24834-44
references: 20516067