title: [A case of pulmonary multicentric Castleman disease which appeared as a very large lesion].
abstract: A 31-year-old man visited our hospital with a persistent cough. Computed tomography (CT) scans of his chest showed a very large mass and multiple nodular lesions in the right lung field, mediastinal and hilar lymph node enlargement and splenomegaly. Laboratory analysis showed polyclonal hyperimmunoglobulinemia and increased levels of serum C-reactive protein (14.05 mg/dl) and interleukin-6 (44.2 pg/ml). The pathological findings of lung specimens obtained using video-assisted thoracoscopy revealed hyperplasia of the lymphoid follicles with germinal centers, plasma cell infiltration which stained positively with either anti-kappa chain or anti-lambda chain antibodies, and fibrosis in the alveolar septum. We made a diagnosis of multicentric Castleman disease based on high levels of serum IL-6, multiple lymph node enlargement and splenomegaly, although this case had histological findings in common not only with Castleman disease but also with inflammatory myofibroblastic tumor. His abnormal chest radiography findings and laboratory data significantly improved 6 months after his first visit, without any treatment. Multicentric Castleman disease showing a very large mass is extremely rare.
authors: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine.
authors: Masaki
authors: M
authors: Okamoto
authors: Tomoaki
authors: T
authors: Hoshino
authors: Masayuki
authors: M
authors: Nakamura
authors: Yohei
authors: Y
authors: Imamura
authors: Kiminori
authors: K
authors: Fujimoto
authors: Koichi
authors: K
authors: Oshima
authors: Tomotaka
authors: T
authors: Kawayama
authors: Hisamichi
authors: H
authors: Aizawa