title: Pregnancy-associated homeostasis and dysregulation: lessons from genetically modified animal models.
abstract: Physiological alterations occur in many organ systems during pregnancy. These changes are necessary for the adaptation to pregnancy-specific physiological processes in mother and fetus, and the placenta plays a critical role in the maintenance of homeostasis in pregnancy. Dysregulation of these functional feto-maternal interactions leads to severe complications. There have been many attempts to create animal models that mimic the hypertensive disorders of pregnancy, especially pre-eclampsia. In this review, we summarize the physiology of pregnancy and placental function, and discuss the placental gene expression in normal pregnancy. In addition, we assess a number of established animal models focusing on a specific pathogenic mechanism of pre-eclampsia, including genetically modified mouse models involving the renin-angiotensin system. Validation of these animal models would contribute significantly to understanding the basic principles of pregnancy-associated homeostasis and the pathogenesis of pre-eclampsia.
authors: Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
authors: Junji
authors: J
authors: Ishida
authors: Toshiki
authors: T
authors: Matsuoka
authors: Tomoko
authors: T
authors: Saito-Fujita
authors: Saki
authors: S
authors: Inaba
authors: Satoshi
authors: S
authors: Kunita
authors: Fumihiro
authors: F
authors: Sugiyama
authors: Ken-ichi
authors: K
authors: Yagami
authors: Akiyoshi
authors: A
authors: Fukamizu