title: Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG).
abstract: In April 2008, a nucleotide-sequence-based, complete genome classification system was developed for group A rotaviruses (RVs). This system assigns a specific genotype to each of the 11 genome segments of a particular RV strain according to established nucleotide percent cutoff values. Using this approach, the genome of individual RV strains are given the complete descriptor of Gx-P[x]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx. The Rotavirus Classification Working Group (RCWG) was formed by scientists in the field to maintain, evaluate and develop the RV genotype classification system, in particular to aid in the designation of new genotypes. Since its conception, the group has ratified 51 new genotypes: as of April 2011, new genotypes for VP7 (G20-G27), VP4 (P[28]-P[35]), VP6 (I12-I16), VP1 (R5-R9), VP2 (C6-C9), VP3 (M7-M8), NSP1 (A15-A16), NSP2 (N6-N9), NSP3 (T8-T12), NSP4 (E12-E14) and NSP5/6 (H7-H11) have been defined for RV strains recovered from humans, cows, pigs, horses, mice, South American camelids (guanaco), chickens, turkeys, pheasants, bats and a sugar glider. With increasing numbers of complete RV genome sequences becoming available, a standardized RV strain nomenclature system is needed, and the RCWG proposes that individual RV strains are named as follows: RV group/species of origin/country of identification/common name/year of identification/G- and P-type. In collaboration with the National Center for Biotechnology Information (NCBI), the RCWG is also working on developing a RV-specific resource for the deposition of nucleotide sequences. This resource will provide useful information regarding RV strains, including, but not limited to, the individual gene genotypes and epidemiological and clinical information. Together, the proposed nomenclature system and the NCBI RV resource will offer highly useful tools for investigators to search for, retrieve, and analyze the ever-growing volume of RV genomic data.
authors: Laboratory of Clinical & Epidemiological Virology, Department of Microbiology & Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, 3000, Leuven, Belgium. jelle.matthijnssens@uz.kuleuven.ac.be
authors: Jelle
authors: J
authors: Matthijnssens
authors: Max
authors: M
authors: Ciarlet
authors: Sarah M
authors: SM
authors: McDonald
authors: Houssam
authors: H
authors: Attoui
authors: Krisztián
authors: K
authors: Bányai
authors: J Rodney
authors: JR
authors: Brister
authors: Javier
authors: J
authors: Buesa
authors: Mathew D
authors: MD
authors: Esona
authors: Mary K
authors: MK
authors: Estes
authors: Jon R
authors: JR
authors: Gentsch
authors: Miren
authors: M
authors: Iturriza-Gómara
authors: Reimar
authors: R
authors: Johne
authors: Carl D
authors: CD
authors: Kirkwood
authors: Vito
authors: V
authors: Martella
authors: Peter P C
authors: PP
authors: Mertens
authors: Osamu
authors: O
authors: Nakagomi
authors: Viviana
authors: V
authors: Parreño
authors: Mustafizur
authors: M
authors: Rahman
authors: Franco M
authors: FM
authors: Ruggeri
authors: Linda J
authors: LJ
authors: Saif
authors: Norma
authors: N
authors: Santos
authors: Andrej
authors: A
authors: Steyer
authors: Koki
authors: K
authors: Taniguchi
authors: John T
authors: JT
authors: Patton
authors: Ulrich
authors: U
authors: Desselberger
authors: Marc
authors: M
authors: Van Ranst
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