title: [Character of lipopolysaccharide-binding protein level changes in different pathological conditions and dysbiosis].
abstract: OBJECTIVE
  To evaluate diagnostic value of lipopolysaccharide-binding protein (LBP) level in different infectious processes and dysbiosis.
  
  
  METHODS
  Serum samples of patients with salmonellosis, urogenital chlamydiosis, community-acquired pneumonia, polypous rhinosinusitis, and bacterial vaginosis were studied.
  
  
  RESULTS
  LBP level were lower in patients with salmonellosis compared to healthy persons and decreased with increasing severity of the disease. Higher levels of LBP were detected in patients with chlamydiosis. Direct correlation between LBP level and etiology and severity of community-acquired pneumonia was demonstrated. In patients with polypous sinusitis, LBP level correlated directly with duration of disease, and inversely--with duration of remission. Twofold increase of mean LBP blood concentration and its correlation with duration of dysbiosis in patients with bacterial vaginosis were revealed.
  
  
  CONCLUSIONS
  Multidirectional modulation of antiendotoxin defense was observed in different pathological conditions.
authors: A R
authors: AR
authors: Mavziutov
authors: G A
authors: GA
authors: Mavziutova
authors: K R
authors: KR
authors: Bondarenko
authors: S E
authors: SE
authors: Senderovich
authors: R G
authors: RG
authors: Nazmutdinova
authors: R T
authors: RT
authors: Murzabaeva
authors: O Z
authors: OZ
authors: Kuzovkina
authors: A O
authors: AO
authors: Akbasheva
authors: D N
authors: DN
authors: Dubrovskaia