title: [Effects of incretins on the regulation of beta-cell mass, proliferation and survival].
abstract: Incretins including GLP-1 and GIP have pleiotropic effects on islet biology especially on beta-cell function. Not only enhancing glucose-stimulated insulin secretion, but incretins exert beta-cell mass maintaining effects by upregulation of proliferation and prevention of cell death (apoptosis). Recent research data revealed detailed molecular mechanisms underlying these effects of incretin on beta-cell biology. These beneficial effects of incretins on the regulation of beta-cell mass could contribute to future therapeutic approaches to diabetes focusing on preservation and upregulation of beta-cell mass as well as function.
authors: Department of Metabolic Medicine, Osaka University Graduate School of Medicine.
authors: Dan
authors: D
authors: Kawamori
authors: Hideaki
authors: H
authors: Kaneto