title: Translating pharmacogenetics into clinical practice: interleukin (IL)28B and inosine triphosphatase (ITPA) polymophisms in hepatitis C virus (HCV) infection.
abstract: Hepatitis C virus (HCV) infection is frequently characterized by evolution to chronicity and by a variable clinical course of the disease. The clinical heterogeneities of HCV infection and the imperfect predictability of the response to interferon (IFN) have suggested the need to search for a genetic basis of clinical features. This led to the discovery of genetic polymorphisms playing a major role in the evolution of infection, as well as on treatment response and adverse effects. This review will cover recent reports on the subject, focusing on the potential use of the new genetic markers in the diagnostic algorithm for the stratification of patients for personalized antiviral regimens.
authors: Clinical Pathology-Toxicology, Ospedale Civile S. Agostino-Estense, Modena, Italy.
authors: Elisabetta
authors: E
authors: Cariani
authors: Department of Gastroenterology, Azienda Ospedaliera-Universitaria, University of Modena and Reggio Emilia, Modena, Italy.
authors: Erica
authors: E
authors: Villa
authors: Clinical Pathology-Toxicology, Ospedale Civile S. Agostino-Estense, Modena, Italy.
authors: Cristina
authors: C
authors: Rota
authors: Department of Gastroenterology, Azienda Ospedaliera-Universitaria, University of Modena and Reggio Emilia, Modena, Italy.
authors: Rosina
authors: R
authors: Critelli
authors: Clinical Pathology-Toxicology, Ospedale Civile S. Agostino-Estense, Modena, Italy.
authors: Tommaso
authors: T
authors: Trenti