title: Ring-closing metathesis (RCM) based synthesis of the macrolactone core of amphidinolactone A.
abstract: A convergent synthesis of the macrolactone core of amphidinolactone A has been achieved, in a 10 step linear sequence with 32% overall yield, through a ring-closing metathesis reaction as the macrolactonization step. The RCM precursor was obtained by the union of acid and alcohol fragments derived from (R)-epichlorohydrin and (R)-2,3-O-isopropylidene glyceraldehyde, respectively.
authors: Organic Chemistry Division-I, Indian Institute of Chemical Technology, CSIR, Hyderabad, India. mohapatra@iict.res.in
authors: Debendra K
authors: DK
authors: Mohapatra
authors: Manas R
authors: MR
authors: Pattanayak
authors: Pragna P
authors: PP
authors: Das
authors: Tapas R
authors: TR
authors: Pradhan
authors: J S
authors: JS
authors: Yadav