title: Fatigue and progression of corpus callosum atrophy in multiple sclerosis.
abstract: Fatigue is one of the most disabling symptoms in multiple sclerosis (MS) patients. There is no or only weak correlation between conventional magnetic resonance imaging (MRI) parameters and level of fatigue. The aim of this study was to investigate the relationship between progression of corpus callosum (CC) atrophy and fatigue in MS patients. This was a cohort study in 70 patients with relapsing form of MS (RRMS) and serial MRIs over a mean follow-up of 4.8 years [67% female, mean age 42 ± 11 years, mean disease duration 9.7 ± 7.6 years, mean Expanded Disability Status Scale (EDSS) 2.8 ± 1.6]. Fatigue was assessed by the Fatigue Severity Scale (FSS). CC size was measured with the CC index (CCI). In total, 40% of the patients suffered from fatigue (mean FSS score 5.3 ± 1.1) and 60% patients had no fatigue (mean FSS score of 2.1 ± 1). Patients with fatigue had higher EDSS scores (p = 0.01) and CC atrophy was more pronounced in patients with fatigue (-21.8 vs. -12.1%, p = 0.005). FSS correlated with CCI change over time (r = -0.33; p = 0.009) and EDSS (p = 0.008; r = 0.361). The association between annualized CCI change and FSS was independent from EDSS, disease duration, gender and age in a multivariate linear regression analysis (p < 0.001). Progression of CC atrophy may play a role in the evolution of MS-related fatigue.
authors: Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland. OYaldizli@uhbs.ch
authors: Özgür
authors: Ö
authors: Yaldizli
authors: Stephanie
authors: S
authors: Glassl
authors: Dietrich
authors: D
authors: Sturm
authors: Athina
authors: A
authors: Papadopoulou
authors: Achim
authors: A
authors: Gass
authors: Barbara
authors: B
authors: Tettenborn
authors: Norman
authors: N
authors: Putzki
references: J Neurol. 1998 Mar;245(3):153-8
references: 9553845
references: Behav Res Ther. 1997 Nov;35(11):1039-46
references: 9431735
references: J Neurol. 2002 May;249(5):535-7
references: 12021941
references: Can J Neurol Sci. 1994 Feb;21(1):9-14
references: 8180914
references: Hum Brain Mapp. 2009 Aug;30(8):2656-66
references: 19067325
references: Arch Phys Med Rehabil. 1984 Mar;65(3):135-8
references: 6703889
references: Arch Neurol. 2004 Feb;61(2):201-7
references: 14967766
references: Swiss Med Wkly. 2007 Sep 8;137(35-36):496-501
references: 17990136
references: Acta Neurol Scand. 2001 Jul;104(1):24-30
references: 11442439
references: Mult Scler. 2000 Jun;6(3):181-5
references: 10871830
references: Arch Neurol. 1988 Apr;45(4):435-7
references: 3355400
references: Neuroimage. 2002 Mar;15(3):559-67
references: 11848698
references: Neurology. 2001 Aug 28;57(4):676-81
references: 11524478
references: J Magn Reson Imaging. 2006 May;23(5):605-18
references: 16596564
references: Curr Opin Neurol. 1996 Dec;9(6):456-60
references: 9007405
references: Ann Neurol. 2005 Dec;58(6):840-6
references: 16283615
references: Mult Scler. 2004 Aug;10(4):387-91
references: 15327034
references: Radiology. 1991 Jul;180(1):215-21
references: 2052698
references: Hum Brain Mapp. 2007 May;28(5):373-82
references: 16933299
references: Arch Neurol. 2003 Dec;60(12):1736-9
references: 14676048
references: Arch Neurol. 1989 Oct;46(10):1121-3
references: 2803071
references: Neurology. 1997 Jun;48(6):1566-71
references: 9191767
references: Lancet. 2004 Mar 20;363(9413):978-88
references: 15043967
references: Radiology. 2001 Sep;220(3):606-10
references: 11526256
references: J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):375-80
references: 17119006
references: J Neurol Sci. 2005 Feb 15;228(2):161-6
references: 15694198
references: J Neurol. 2010 Aug;257(8):1256-64
references: 20198382
references: Eur Neurol. 2001;45(1):11-8
references: 11150835
references: J Neurol Sci. 2006 Apr 15;243(1-2):39-45
references: 16434057
references: Arch Neurol. 2001 Jan;58(1):105-11
references: 11176943
references: J Neurol. 2006 Jul;253(7):896-902
references: 16525881
references: Radiology. 1986 Aug;160(2):363-7
references: 3726114
references: J Neurol. 1999 Jun;246(6):454-8
references: 10431770
references: Neurology. 1999 Sep 22;53(5):1151-3
references: 10496289
references: Arq Neuropsiquiatr. 2007 Dec;65(4A):931-5
references: 18094848
references: J Psychosom Res. 1998 Jul;45(1):33-8
references: 9720853
references: J Neurol. 2000 Jul;247(7):506-9
references: 10993490
references: J Neurol Sci. 2002 Feb 15;194(1):71-4
references: 11809169
references: Neurology. 1989 Feb;39(2 Pt 1):161-6
references: 2915783
references: J Neurol Sci. 1998 Oct 8;160(2):164-70
references: 9849800