title: Potential use of stem cells for kidney regeneration.
abstract: Significant advances have been made in stem cell research over the past decade. A number of nonhematopoietic sources of stem cells (or progenitor cells) have been identified, including endothelial stem cells and neural stem cells. These discoveries have been a major step toward the use of stem cells for potential clinical applications of organ regeneration. Accordingly, kidney regeneration is currently gaining considerable attention to replace kidney dialysis as the ultimate therapeutic strategy for renal failure. However, due to anatomic complications, the kidney is believed to be the hardest organ to regenerate; it is virtually impossible to imagine such a complicated organ being completely rebuilt from pluripotent stem cells by gene or chemical manipulation. Nevertheless, several groups are taking on this big challenge. In this manuscript, current advances in renal stem cell research are reviewed and their usefulness for kidney regeneration discussed. We also reviewed the current knowledge of the emerging field of renal stem cell biology.
authors: Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.
authors: Takashi
authors: T
authors: Yokoo
authors: Kei
authors: K
authors: Matsumoto
authors: Shinya
authors: S
authors: Yokote
references: Kidney Int. 2010 Mar;77(5):407-16
references: 20016472
references: Development. 2006 Jan;133(1):151-61
references: 16319116
references: Cell. 2007 Nov 30;131(5):861-72
references: 18035408
references: Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11307-12
references: 11027332
references: Kidney Int. 2003 Apr;63(4):1195-204
references: 12631335
references: Nature. 2007 Jul 19;448(7151):313-7
references: 17554338
references: Kidney Int. 1990 Nov;38(5):991-7
references: 2266685
references: J Am Soc Nephrol. 2003 May;14(5):1188-99
references: 12707389
references: J Clin Invest. 2005 Jul;115(7):1743-55
references: 16007251
references: J Clin Invest. 2005 Jul;115(7):1756-64
references: 16007252
references: J Am Soc Nephrol. 2007 Jun;18(6):1709-20
references: 17475814
references: Transplantation. 2000 Apr 15;69(7):1470-8
references: 10798773
references: Cell. 2006 Aug 25;126(4):663-76
references: 16904174
references: Cell. 2010 Sep 3;142(5):787-99
references: 20813264
references: Nat Biotechnol. 2007 Oct;25(10):1177-81
references: 17724450
references: Nat Med. 2010 Jul;16(7):814-20
references: 20543851
references: Science. 1997 Apr 4;276(5309):71-4
references: 9082988
references: Science. 2007 Dec 21;318(5858):1920-3
references: 18063756
references: Nat Med. 2010 Aug;16(8):927-33
references: 20628374
references: Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2344-9
references: 11782534
references: Nature. 1973 Mar 9;242(5393):115-6
references: 4550020
references: Nature. 2007 Jul 19;448(7151):318-24
references: 17554336
references: Nature. 1973 Jun 22;243(5408):472-3
references: 4795515
references: Biochem Biophys Res Commun. 2009 Jul 31;385(3):330-5
references: 19450546
references: Nat Med. 2008 Feb;14(2):213-21
references: 18193059
references: Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):998-1003
references: 12525695
references: Exp Nephrol. 2002;10(2):102-13
references: 11937757
references: Curr Opin Genet Dev. 2003 Oct;13(5):502-7
references: 14550416
references: Transplantation. 2008 Jun 15;85(11):1654-8
references: 18551074
references: J Clin Invest. 2003 Jul;112(1):42-9
references: 12824456
references: Nat Med. 2000 Nov;6(11):1282-6
references: 11062543
references: Biochem Biophys Res Commun. 2005 Oct 21;336(2):585-95
references: 16140269
references: Naturwissenschaften. 1999 May;86(5):224-7
references: 10360269
references: J Am Soc Nephrol. 2009 Nov;20(11):2338-47
references: 19729441
references: J Nephrol. 2012 Jan-Feb;25(1):50-5
references: 21500184
references: J Am Soc Nephrol. 2006 Apr;17(4):1026-34
references: 16524947
references: Biochem Biophys Res Commun. 2005 Apr 1;329(1):288-95
references: 15721305
references: Am J Kidney Dis. 1998 Mar;31(3):383-97
references: 9506676
references: Proc Natl Acad Sci U S A. 1981 Dec;78(12):7634-8
references: 6950406
references: Kidney Int. 1998 Jul;54(1):27-37
references: 9648060
references: Artif Organs. 2010 Aug;34(8):642-7
references: 20497162
references: Stem Cells. 2009 Dec;27(12):3063-73
references: 19750536
references: J Am Soc Nephrol. 2005 Jun;16(6):1623-31
references: 15872079
references: J Am Soc Nephrol. 2005 Dec;16(12):3527-34
references: 16267156
references: Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3296-300
references: 15728383
references: J Am Soc Nephrol. 2004 May;15(5):1126-32
references: 15100352
references: J Clin Invest. 2010 Sep;120(9):3120-6
references: 20739754
references: Nat Biotechnol. 2002 Jul;20(7):689-96
references: 12089553
references: Proc Natl Acad Sci U S A. 1993 May 15;90(10):4528-32
references: 8506294