title: [Immunobiological properties of recombinant atoxic forms of the Pseudomonas aeruginosa exotoxin A].
abstract: OBJECTIVE
  Evaluation of immunobiological properties of recombinant atoxic forms of the Pseudomonas aeruginosa exotoxin. MATERIALS AND METHODS. 3 recombinant atoxic forms of the P. aeruginosa exotoxin A were produced and studied: aTox1, consisting only of exotoxin A domain 1; aTox1,2, consisting of domain 1 and 2; and aTox1,2,delta3, consisting of both domain 1 and 2, and part of domain 3.
  
  
  RESULTS
  aToxl,2 and aTox1,2,delta3 had distinctive antigenic properties. Formulations based on these recombinant proteins were immunogenic and protected animals from exotoxin A in experimental conditions.
  
  
  CONCLUSIONS
  These results maybe used to construct direct-action immunobiological formulations.
authors: M A
authors: MA
authors: Isakov
authors: A S
authors: AS
authors: Soldatenkova
authors: A A
authors: AA
authors: Kaloshin
authors: N A
authors: NA
authors: Mikhaĭlova