title: G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance.
abstract: G protein-coupled receptor kinase 2 (GRK2) is emerging as a key, integrative node in many signalling pathways. Besides its canonical role in the modulation of the signalling mediated by many G protein-coupled receptors (GPCR), this protein can display a very complex network of functional interactions with a variety of signal transduction partners, in a stimulus, cell type, or context-specific way. We review herein recent data showing that GRK2 can regulate insulin-triggered transduction cascades at different levels and that this protein plays a relevant role in insulin resistance and obesity in vivo, what uncovers GRK2 as a potential therapeutic target in the treatment of these disorders.
authors: Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (CSIC-UAM), 28049 Madrid, Spain. fmayor@cbm.uam.es
authors: Federico
authors: F
authors: Mayor
authors: Elisa
authors: E
authors: Lucas
authors: María
authors: M
authors: Jurado-Pueyo
authors: Lucia
authors: L
authors: Garcia-Guerra
authors: Iria
authors: I
authors: Nieto-Vazquez
authors: Rocio
authors: R
authors: Vila-Bedmar
authors: Sonia
authors: S
authors: Fernández-Veledo
authors: Cristina
authors: C
authors: Murga