title: Bax inhibitor-1: a highly conserved endoplasmic reticulum-resident cell death suppressor.
abstract: In spite of fundamental differences between plant and animal cells, it is remarkable that some cell death regulators that were identified to control cell death in metazoans can also function in plants. The fact that most of these proteins do not have structural homologs in plant genomes suggests that they may be targeting a highly conserved 'core' mechanism with conserved functions that is present in all eukaryotes. The ubiquitous Bax inhibitor-1 (BI-1) is a common cell death suppressor in eukaryotes that has provided a potential portal to this cell death core. In this review, we will update the current status of our understanding on the function and activities of this intriguing protein. Genetic, molecular and biochemical studies have so far suggested a consistent view that BI-1 is an endoplasmic reticulum (ER)-resident transmembrane protein that can interact with multiple partners to alter intracellular Ca(2+) flux control and lipid dynamics. Functionally, the level of BI-1 protein has been hypothesized to have the role of a rheostat to regulate the threshold of ER-stress inducible cell death. Further, delineation of the cell death suppression mechanism by BI-1 should shed light on an ancient cell death core-control pathway in eukaryotes, as well as novel ways to improve stress tolerance.
authors: Department of Environmental Science and Technology, Saitama University, Saitama 338-8570, Japan.
authors: T
authors: T
authors: Ishikawa
authors: N
authors: N
authors: Watanabe
authors: M
authors: M
authors: Nagano
authors: M
authors: M
authors: Kawai-Yamada
authors: E
authors: E
authors: Lam
references: Biochem Biophys Res Commun. 2002 Jan 11;290(1):457-62
references: 11779192
references: Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18327-32
references: 17989229
references: Plant J. 2000 Feb;21(4):393-9
references: 10758491
references: Planta. 2005 Mar;220(5):804-7
references: 15660205
references: Adv Lipid Res. 1993;26:253-74
references: 8379454
references: Int J Mol Sci. 2009 Jul 10;10(7):3149-67
references: 19742129
references: Plant J. 2009 Apr;58(1):122-34
references: 19054355
references: Theor Appl Genet. 2009 Feb;118(3):455-63
references: 18956174
references: Bioessays. 2003 Sep;25(9):888-96
references: 12938178
references: J Biol Chem. 2000 Sep 22;275(38):29207-16
references: 10859306
references: J Plant Physiol. 2009 Oct 15;166(15):1685-93
references: 19524322
references: Plant Signal Behav. 2010 Sep;5(9):1115-8
references: 20818179
references: Plant Mol Biol. 2004 Sep;56(1):15-27
references: 15604726
references: Genetics. 2000 Sep;156(1):341-50
references: 10978297
references: Biol Chem. 2005 Feb;386(2):161-6
references: 15843160
references: FEBS J. 2009 Apr;276(8):2285-91
references: 19290886
references: New Phytol. 2010 May;186(3):681-95
references: 20298483
references: Mol Cell. 2009 Mar 27;33(6):679-91
references: 19328063
references: Nature. 2002 Mar 28;416(6879):447-51
references: 11919636
references: Cell. 2007 Dec 14;131(6):1047-58
references: 18083096
references: Trends Plant Sci. 2003 Oct;8(10):505-12
references: 14557048
references: Plant J. 2003 Feb;33(3):425-34
references: 12581301
references: Cell Microbiol. 2007 Nov;9(11):2571-85
references: 17714518
references: Curr Biol. 1999 Jul 15;9(14):775-8
references: 10421577
references: Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6088-93
references: 20231441
references: J Biol Chem. 2008 Jun 6;283(23):15946-55
references: 18378668
references: Plant Physiol. 2001 Nov;127(3):949-62
references: 11706177
references: Mol Plant Microbe Interact. 2010 Sep;23(9):1217-27
references: 20687811
references: FEBS Lett. 1999 Dec 31;464(3):143-7
references: 10618494
references: Plant Physiol. 1999 Apr;119(4):1165-76
references: 10198075
references: Plant Cell Physiol. 2009 Feb;50(2):341-59
references: 19106119
references: Mol Cell. 2004 Aug 13;15(3):355-66
references: 15304216
references: J Biol Chem. 1998 Nov 27;273(48):31985-91
references: 9822670
references: Rapid Commun Mass Spectrom. 2007;21(7):1304-14
references: 17340572
references: J Biol Chem. 2008 Feb 8;283(6):3200-3210
references: 18039663
references: Trends Plant Sci. 2010 Dec;15(12):656-63
references: 20934367
references: Mol Cell. 1998 Feb;1(3):337-46
references: 9660918
references: Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5555-60
references: 12704231
references: PLoS One. 2007 Aug 08;2(8):e718
references: 17684564
references: Plant Cell Physiol. 2010 Jan;51(1):9-20
references: 19919949
references: Plant Physiol. 2007 Feb;143(2):650-60
references: 17142482
references: Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15805-10
references: 15505199
references: Plant Cell. 2000 Oct;12(10):1811-22
references: 11041878
references: J Cell Sci. 2009 Apr 15;122(Pt 8):1126-33
references: 19339548
references: J Biol Chem. 2009 Oct 9;284(41):27998-28003
references: 19674971
references: Planta. 2003 Jan;216(3):377-86
references: 12520328
references: Cell. 2004 Jan 23;116(2):205-19
references: 14744432
references: J Biol Chem. 1997 Nov 7;272(45):28281-8
references: 9353282
references: J Biol Chem. 2006 Aug 11;281(32):22684-94
references: 16772288
references: Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6957-62
references: 11381106
references: Mutat Res. 2005 Jan 6;569(1-2):29-63
references: 15603751
references: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7956-61
references: 10393929
references: Genes Dev. 2003 Nov 1;17(21):2636-41
references: 14563678
references: Plant Methods. 2010 Nov 30;6:27
references: 21118545
references: EMBO J. 2010 Mar 3;29(5):1007-18
references: 20075858
references: J Cell Sci. 2004 May 15;117(Pt 12):2591-8
references: 15159454
references: Biochem J. 2003 Jan 15;369(Pt 2):199-211
references: 12408751
references: Plant Cell. 2008 Nov;20(11):3107-21
references: 19017746
references: Cell Death Differ. 2006 Mar;13(3):363-73
references: 16397583
references: J Biol Chem. 2007 Jul 27;282(30):21618-28
references: 17526500
references: Genes Dev. 2002 Feb 15;16(4):490-502
references: 11850411
references: J Biol Chem. 2002 May 31;277(22):19304-14
references: 11904292
references: Plant J. 2006 Mar;45(6):884-94
references: 16507080
references: Plant Cell. 2008 Jul;20(7):1862-78
references: 18612100
references: Gene. 2003 Dec 24;323:101-13
references: 14659883
references: Plant Cell. 2004 Jan;16(1):21-32
references: 14671021
references: Apoptosis. 2004 May;9(3):299-307
references: 15258461
references: Plant Cell. 2008 Nov;20(11):3163-79
references: 19001565
references: Plant Physiol. 2004 Jul;135(3):1630-41
references: 15235116
references: Cell. 1997 Mar 7;88(5):695-705
references: 9054509
references: Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12295-300
references: 11593047
references: Plant Cell Physiol. 2000 Jun;41(6):676-83
references: 10945336
references: Nat Rev Mol Cell Biol. 2004 Apr;5(4):305-15
references: 15071555