title: Correlation between arterial blood volume obtained by arterial spin labelling and cerebral blood volume in intracranial tumours.
abstract: OBJECTIVE
  To compare measurements of the arterial blood volume (aBV), a perfusion parameter calculated from arterial spin labelling (ASL), and cerebral blood volume (CBV), calculated from dynamic susceptibility contrast (DSC) MRI. In the clinic, CBV is used for grading of intracranial tumours.
  
  
  METHODS
  Estimates of aBV from the model-free ASL technique quantitative STAR labelling of arterial regions (QUASAR) experiment and of DSC-CBV were obtained at 3T in ten patients with eleven tumours (three grade III gliomas, four glioblastomas and four meningiomas, two in one patient). Parametric values of aBV and CBV were determined in the tumour as well as in normal grey matter (GM), and tumour-to-GM aBV and CBV ratios were calculated.
  
  
  RESULTS
  In a 4-pixel ROI representing maximal tumour values, the coefficient of determination R (2) was 0.61 for the comparison of ASL-based aBV tumour-to-GM ratios and DSC-MRI-based CBV tumour-to-GM ratios and 0.29 for the comparison of parametric values of ASL-aBV and DSC-CBV, under the assumption of proportionality. Both aBV and CBV showed a non-significant tendency to increase when going from grade III gliomas to glioblastomas to meningiomas.
  
  
  CONCLUSIONS
  These results suggest that measurement of aBV is a potential tool for non-invasive assessment of blood volume in intracranial tumours.
authors: Department of Diagnostic Radiology, Lund University, Lund, Sweden. danielle.van_westen@med.lu.se
authors: Danielle
authors: D
authors: van Westen
authors: Esben T
authors: ET
authors: Petersen
authors: Ronnie
authors: R
authors: Wirestam
authors: Roger
authors: R
authors: Siemund
authors: Karin Markenroth
authors: KM
authors: Bloch
authors: Freddy
authors: F
authors: Ståhlberg
authors: Isabella M
authors: IM
authors: Björkman-Burtscher
authors: Linda
authors: L
authors: Knutsson
references: Invest Radiol. 2004 May;39(5):277-87
references: 15087722
references: Magn Reson Med. 1992 Jan;23(1):37-45
references: 1734182
references: Magn Reson Med. 2006 Feb;55(2):219-32
references: 16416430
references: AJNR Am J Neuroradiol. 2004 Feb;25(2):214-21
references: 14970020
references: Magn Reson Imaging. 2010 Jan;28(1):1-7
references: 19695822
references: Exp Toxicol Pathol. 1995 May;47(2-3):89-94
references: 7580112
references: Ann Nucl Med. 2001 Apr;15(2):111-6
references: 11448068
references: Magn Reson Med. 1995 Sep;34(3):293-301
references: 7500865
references: AJNR Am J Neuroradiol. 2006 Apr;27(4):859-67
references: 16611779
references: Magn Reson Med. 2003 Jul;50(1):164-74
references: 12815691
references: Radiology. 2006 Feb;238(2):658-67
references: 16396838
references: Ann Pharmacother. 2007 Sep;41(9):1481-5
references: 17684032
references: Int J Radiat Oncol Biol Phys. 1994 Jun 15;29(3):427-31
references: 8005794
references: Magn Reson Med. 2006 Jul;56(1):187-97
references: 16724299
references: Neurology. 2006 Jun 27;66(12):1899-906
references: 16801657
references: Radiology. 2003 Aug;228(2):523-32
references: 12819338
references: J Magn Reson Imaging. 2005 Oct;22(4):475-82
references: 16161080
references: AJR Am J Roentgenol. 1998 Dec;171(6):1479-86
references: 9843274
references: J Nucl Med. 1992 Dec;33(12):2133-7
references: 1334136
references: AJR Am J Roentgenol. 2002 Sep;179(3):783-9
references: 12185064
references: Radiology. 1994 Apr;191(1):41-51
references: 8134596
references: J Neurooncol. 1997 May;32(3):253-65
references: 9049887
references: Clin Cancer Res. 2000 Jun;6(6):2189-200
references: 10873068
references: Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):212-6
references: 1729691
references: AJNR Am J Neuroradiol. 2008 Apr;29(4):688-93
references: 18184842
references: Radiology. 1994 Aug;192(2):513-20
references: 8029425
references: Neuroimage. 2010 Jan 1;49(1):104-13
references: 19660557
references: Radiology. 1994 Dec;193(3):637-41
references: 7972800
references: Clin Radiol. 2005 Apr;60(4):493-502
references: 15767107
references: Radiology. 2002 Sep;224(3):797-803
references: 12202717
references: Ultrasound Obstet Gynecol. 1999 Jun;13(6):425-30
references: 10423807
references: AJNR Am J Neuroradiol. 2003 Nov-Dec;24(10):1989-98
references: 14625221
references: Radiology. 1999 Jun;211(3):791-8
references: 10352608
references: AJNR Am J Neuroradiol. 2006 Jan;27(1):85-93
references: 16418363