title: Synthesis of 3-guaninyl- and 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone nucleosides.
abstract: L- and D-glutamic acids, as well as trans-4-hydroxy-L-proline, are converted to the corresponding 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analog. The protecting group used to block the lactam nitrogen in key intermediates has a significant effect on the diastereoselectivity of the coupling reaction with adenine or guanine.
authors: Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269-3060, United States.
authors: Abdullah
authors: A
authors: Saleh
authors: John G
authors: JG
authors: D'Angelo
authors: Martha D
authors: MD
authors: Morton
authors: Jesse
authors: J
authors: Quinn
authors: Kendra
authors: K
authors: Redden
authors: Rafal W
authors: RW
authors: Mielguz
authors: Christopher
authors: C
authors: Pavlik
authors: Michael B
authors: MB
authors: Smith