title: Rosiglitazone as an option for patients with acromegaly: a case series.
abstract: BACKGROUND
  In the patient with acromegaly, pituitary surgery is the therapeutic standard. Despite undergoing surgery, a significant number of patients with acromegaly continue to have uncontrolled growth hormone secretion. These patients require other treatments such as external irradiation and/or drug therapy.
  
  
  METHODS
  We present the clinical and laboratory responses to six months of treatment with rosiglitazone in four cases. In all four cases, the patients had persistent growth hormone overproduction despite previous surgical treatment and other conventional therapy. Case 1 is a 57-year-old Caucasian woman, case 2 is a 51-year-old Hispanic man, case 3 is a 32-year-old Hispanic woman, and case 4 is a 36-year-old Hispanic man. In three of these patients, basal and nadir growth hormone and insulin-like growth factor 1 levels were significantly decreased (P < 0.05 and P < 0.01, respectively).
  
  
  CONCLUSIONS
  Rosiglitazone could be a treatment option in select patients with acromegaly.
authors: Subdirección de Investigación, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, N,L,, México. hectoreloytamez@aol.com.
authors: Héctor E
authors: HE
authors: Tamez-Pérez
authors: Ana
authors: A
authors: Bahena-García
authors: María D
authors: MD
authors: Gómez de Ossio
authors: Hugo
authors: H
authors: Gutiérrez-Hermosillo
authors: Alejandra L
authors: AL
authors: Tamez-Peña
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