title: [Open abdomen management treatment of liver injury in rats with abdominal compartment syndrome and sepsis].
abstract: OBJECTIVE
  To evaluate the open and closed management treatment of liver injury in rats with sepsis and abdominal compartment syndrome (ACS).
  
  
  METHODS
  The sepsis and ACS rats (n = 72) were randomized divided into two groups. One group used closed management (n = 36), the other accepted the open abdomen management (n = 36). The rats were killed at 1, 6 h, 1, 3, 5, 7 d after operation. Blood was collected for liver function tests. Liver sections assessed pathologically and the expressions of Toll-like receptor 4 (TLR4), tumor necrosis factor (TNF)-α, interleukin (IL)-6, signal transducers actuators of transcription (STAT3) and suppressor of cytokine signaling 3 (SOCS3) of rat livers were examined by RT-PCR.
  
  
  RESULTS
  The early stage after operation, TNF-α and IL-6 concentrations, STAT3 expressions in rat liver were higher in open abdomen rats than the closed management ones (P < 0.05). TLR4 and SOCS3 expressions were lower in open abdomen rats than the closed management ones (P < 0.05). Aspartate aminotransferase, alanine aminotransferase levels also was lower in open abdomen ones (P < 0.05).
  
  
  CONCLUSIONS
  The randomized study demonstrates that open abdomen management could improve liver regeneration in the early stage after operation. Also open abdomen could reduce inflammatory response by reducing TLR4 expressions.
authors: School of Medicine, Nanjing University, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China.
authors: Jun
authors: J
authors: Chen
authors: Jian-an
authors: JA
authors: Ren
authors: Wei-wei
authors: WW
authors: Zhang
authors: Guo-sheng
authors: GS
authors: Gu
authors: Chao-gang
authors: CG
authors: Fan
authors: Xin-bo
authors: XB
authors: Wang
authors: Jie-shou
authors: JS
authors: Li