title: Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.
abstract: Tyrosine kinase-2 (Tyk2), a member of the Jak family of kinases, mediates the signals triggered by various cytokines, including type I IFNs, IL-12, and IL-23. In the current study, we investigated the in vivo involvement of Tyk2 in several IL-12/Th1- and IL-23/Th17-mediated models of experimental diseases, including methylated BSA injection-induced footpad thickness, imiquimod-induced psoriasis-like skin inflammation, and dextran sulfate sodium- or 2,4,6-trinitrobenzene sulfonic acid-induced colitis. In these disease models, Tyk2 deficiency influenced the phenotypes in immunity and/or inflammation. Our findings demonstrate a somewhat broader contribution of Tyk2 to immune systems than previously expected and suggest that Tyk2 may represent an important candidate for drug development by targeting both the IL-12/Th1 and IL-23/Th17 axes.
authors: Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors: Masayuki
authors: M
authors: Ishizaki
authors: Toshihiko
authors: T
authors: Akimoto
authors: Ryuta
authors: R
authors: Muromoto
authors: Mika
authors: M
authors: Yokoyama
authors: Yuya
authors: Y
authors: Ohshiro
authors: Yuichi
authors: Y
authors: Sekine
authors: Hiroaki
authors: H
authors: Maeda
authors: Kazuya
authors: K
authors: Shimoda
authors: Kenji
authors: K
authors: Oritani
authors: Tadashi
authors: T
authors: Matsuda