title: Anoctamins.
abstract: Endogenous Ca(2+)-activated Cl(-) channels (CaCC) demonstrate biophysical and pharmacological properties that are well represented in cells overexpressing anoctamin 1 (Ano 1, TMEM16A), a protein that has been identified recently as CaCC. Proteins of the anoctamin family (anoctamin 1-10, TMEM16A-K) are widely expressed. The number of reports demonstrating their physiological and clinical relevance is quickly rising. Anoctamins gain additional interest through their potential role in cell volume regulation and malignancy. Available data suggest that Ano 1 forms stable dimers and probably liaise with accessory proteins such as calmodulin or other anoctamins. In order to understand how anoctamins produce Ca(2+)-activated Cl(-) currents, it will be necessary to obtain better insight into their molecular structure, interactions with partner proteins, and mode of activation.
authors: Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, Regensburg, Germany. karl.kunzelmann@vkl.uni-regensburg.de
authors: Karl
authors: K
authors: Kunzelmann
authors: Yuemin
authors: Y
authors: Tian
authors: Joana Raquel
authors: JR
authors: Martins
authors: Diana
authors: D
authors: Faria
authors: Patthara
authors: P
authors: Kongsuphol
authors: Jiraporn
authors: J
authors: Ousingsawat
authors: Frank
authors: F
authors: Thevenod
authors: Eleni
authors: E
authors: Roussa
authors: Jason
authors: J
authors: Rock
authors: Rainer
authors: R
authors: Schreiber
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