title: Clinical significance of serum c-erbB-2 protein in patients with primary breast cancer.
abstract: We measured serum c-erbB-2 protein concentration in 167 patients with primary breast cancer. The rate of positive results was 6%. The positivity rate of serum c-erbB-2 protein did not differ among stages I, II, IIIa and IIIb. However the positivity rate on stage IV was 50% (3/6) and significantly higher than the other stages (p=0.0006). The rate of;positive results correlated significantly with lymph node status (p=0.0037). We concluded that the level of serum c-erbB-2 protein reflected the malignant characteristics of primary breast cancer and its measurement may be useful for a preoperative evaluation of primary breast cancer.
authors: SAPPORO SOCIAL INSURANCE GEN HOSP,SAPPORO,HOKKAIDO 004,JAPAN. HOKKAIDO UNIV,SCH MED,DEPT PATHOL 2,SAPPORO,HOKKAIDO 060,JAPAN. JICHI MED SCH,DEPT CLIN PATHOL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN.
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authors: Takahashi
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authors: Sasaki
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authors: Okawa
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authors: Taguchi
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authors: Sasaki
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authors: Uchino
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authors: Hata
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authors: Fujita
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authors: Nagashima
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authors: Ito
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authors: Kawai