title: Random-start gonadotropin-releasing hormone (GnRH) antagonist-treated cycles with GnRH agonist trigger for fertility preservation.
abstract: OBJECTIVE
  To describe our experience with random-start IVF with the use of GnRH agonist for final oocyte maturation, to reduce the risk of ovarian hyperstimulation syndrome.
  
  
  METHODS
  Case series.
  
  
  METHODS
  University-based center for reproductive endocrinology and infertility.
  
  
  METHODS
  Patients with a new diagnosis of cancer who presented with a narrow time frame for IVF before initiating cancer therapy.
  
  
  METHODS
  Random-start GnRH antagonist cycles with GnRH agonist trigger for final oocyte maturation.
  
  
  METHODS
  Number of oocytes retrieved, fertilization rate, rates of ovarian hyperstimulation syndrome.
  
  
  RESULTS
  Cycles were started in the late follicular or luteal phase, and the duration of controlled ovarian hyperstimulation ranged between 8-13 days. A total of 14-40 oocytes were retrieved and 5-20 embryos cryopreserved for each patient.
  
  
  CONCLUSIONS
  Random-start IVF is a reasonable option for fertility preservation in those cancer patients for whom the treatment window may be narrow. In addition, the use of a GnRH agonist for final oocyte maturation may decrease the potential risk of ovarian hyperstimulation syndrome.
authors: University of Pittsburgh Medical Center, Department of Obstetrics and Gynecology, 300 Halket Street, Pittsburgh, PA 15213, USA. nayaksr2@upmc.edu
authors: Shweta R
authors: SR
authors: Nayak
authors: Anthony N
authors: AN
authors: Wakim