title: Human pluripotent stem cells: from biology to cell therapy.
abstract: Human pluripotent stem cells (PSCs), encompassing embryonic stem cells and induced pluripotent stem cells, proliferate extensively and differentiate into virtually any desired cell type. PSCs endow regenerative medicine with an unlimited source of replacement cells suitable for human therapy. Several hurdles must be carefully addressed in PSC research before these theoretical possibilities are translated into clinical applications. These obstacles are: (1) cell proliferation; (2) cell differentiation; (3) genetic integrity; (4) allogenicity; and (5) ethical issues. We discuss these issues and underline the fact that the answers to these questions lie in a better understanding of the biology of PSCs. To contribute to this aim, we have developed a free online expression atlas, Amazonia!, that displays for each human gene a virtual northern blot for PSC samples and adult tissues (http://www.amazonia.transcriptome.eu).
authors: Jean-Marie Ramirez, Qiang Bai, Marilyne Dijon-Grinand, Said Assou, Samir Hamamah, John De Vos, INSERM, U847, Montpellier, F 34000, France.
authors: Jean-Marie
authors: JM
authors: Ramirez
authors: Qiang
authors: Q
authors: Bai
authors: Marilyne
authors: M
authors: Dijon-Grinand
authors: Said
authors: S
authors: Assou
authors: Sabine
authors: S
authors: Gerbal-Chaloin
authors: Samir
authors: S
authors: Hamamah
authors: John
authors: J
authors: De Vos
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