title: Cost-effectiveness of enhancing adherence to therapy with statins in the setting of primary cardiovascular prevention. Evidence from an empirical approach based on administrative databases.
abstract: OBJECTIVE
  To estimate the cost-effectiveness of enhancing adherence to statin therapy across a large population without signs of pre-existing cardiovascular disease.
  
  
  RESULTS
  The cohort of 84,262 patients aged 40-79 years, resident in the Italian Lombardia Region, who were newly treated with statins during 2002-2003, was followed from index prescription until 2007. During follow-up the 1397 patients who experienced a hospitalization for ischemic heart disease (IHD) were identified (outcome). Adherence from index prescription until the date of hospitalization or censoring was measured by the proportion of days covered by the therapy with statins (PDC). Cost-effectiveness of enhancing adherence was measured through the incremental cost-effectiveness ratio (ICER). The robustness of findings was tested in a sensitivity analysis. Interventions to increase the average level of adherence from 45% (baseline) to 50% ("soft" intervention) or to 90% ("hard" intervention) reduced the number of patients who experience IHD (from 38.9 to 38.4 or 35.8 events every 10,000 person-year, respectively), and increased the cost for drug therapy (from 1326 to 1452 or 2626 thousand euros every 10,000 person-year, respectively). ICER ranged from 243 (95% CI: 230-259) to 413 (391-439) thousand euros every 10,000 person-year for the soft and hard interventions, respectively.
  
  
  CONCLUSIONS
  Interventions aimed at enhancing adherence to statin therapy in the setting of primary cardiovascular prevention might offer important benefits in reducing the risk of cardiovascular outcome, but at a substantial cost.
authors: Department of Statistics, Unit of Biostatistics and Epidemiology, University of Milano-Bicocca, Milan, Italy. giovanni.corrao@unimib.it
authors: Giovanni
authors: G
authors: Corrao
authors: Lorenza
authors: L
authors: Scotti
authors: Antonella
authors: A
authors: Zambon
authors: Gianluca
authors: G
authors: Baio
authors: Federica
authors: F
authors: Nicotra
authors: Valentino
authors: V
authors: Conti
authors: Stefano
authors: S
authors: Capri
authors: Elena
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authors: Tragni
authors: Luca
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authors: Merlino
authors: Alberico L
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authors: Catapano
authors: Giuseppe
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authors: Mancia