title: Giant Merkel cell carcinoma of the eyelid: a case report and review of the literature.
abstract: Merkel cell carcinoma (MCC) is a rare cutaneous tumor and cases located in the eyelid have been described, but still its rarity may lead to difficulty in diagnosis and delay in treatment. A 51-year-old female patient that presented with large lesions in the eyelid underwent surgery after the diagnosis of acute chalazion. Following respiratory distress secondary to pulmonary metastasis, the patient's condition deteriorated and was not fit for complete excision treatment. Histopathological investigation of the biopsies, taken from the tumor, revealed that it was undifferentiated small cell carcinoma. Our aim with this paper is to point out that more cases should be reported for more effective diagnosis, histopathological study, clinical investigation, treatment and prognosis of this specific neoplasm.
authors: TianJin Medical University Eye Center, 300084 TianJin, PR China. lq1012@yahoo.com.cn
authors: Luxia
authors: L
authors: Chen
authors: Limin
authors: L
authors: Zhu
authors: Jianguo
authors: J
authors: Wu
authors: Tingting
authors: T
authors: Lin
authors: Baocun
authors: B
authors: Sun
authors: Yanjin
authors: Y
authors: He
references: Br J Dermatol. 1991 May;124(5):509
references: 2039736
references: Cancer. 1997 Sep 1;80(5):881-5
references: 9307187
references: Expert Rev Anticancer Ther. 2001 Oct;1(3):441-5
references: 12113110
references: J Cutan Pathol. 2009 Sep;36(9):983-6
references: 19017040
references: Appl Immunohistochem Mol Morphol. 2006 Jun;14(2):244-8
references: 16785798
references: Int J Radiat Oncol Biol Phys. 1995 Jan 15;31(2):325-31
references: 7836086
references: Graefes Arch Clin Exp Ophthalmol. 1998 Aug;236(8):561-6
references: 9717649
references: Ophthalmology. 2008 Jan;115(1):195-201
references: 17531320
references: Can J Ophthalmol. 2007 Jun;42(3):469-70
references: 17508048
references: Histopathology. 2005 Jun;46(6):622-34
references: 15910593
references: Orbit. 2008;27(4):331-3
references: 18716977
references: Science. 2008 Feb 22;319(5866):1096-100
references: 18202256
references: Can J Ophthalmol. 2010 Feb;45(1):85-6
references: 20130724
references: Br J Dermatol. 2009 Jul;161(1):90-4
references: 19438439
references: J Am Acad Dermatol. 2007 Jul;57(1):166-9
references: 17482714
references: Arch Dermatol. 1972 Jan;105(1):107-10
references: 5009611
references: Am Surg. 2009 Jul;75(7):615-9
references: 19655608
references: Am J Dermatopathol. 2006 Apr;28(2):99-104
references: 16625069
references: J Clin Oncol. 1988 Dec;6(12):1863-73
references: 3199169
references: J Clin Oncol. 2005 Apr 1;23(10):2300-9
references: 15800320
references: J Am Acad Dermatol. 2008 Mar;58(3):375-81
references: 18280333
references: Arch Dermatol. 2006 Jun;142(6):685-90
references: 16785370
references: Cancer. 1999 Jun 15;85(12):2589-95
references: 10375107
references: Orbit. 2005 Dec;24(4):273-5
references: 16354638
references: Int J Radiat Oncol Biol Phys. 2006 Jan 1;64(1):114-9
references: 16125873