title: Steatosis induced by the accumulation of apolipoprotein A-I and elevated ROS levels in H-ras12V transgenic mice contributes to hepatic lesions.
abstract: Hepatic steatosis is considered to have an important impact on liver tumorigenesis, despite a lack of clear experimental evidence. Histopathological analysis of H-ras12V transgenic mice showed liver lesions on a steatosis background had significantly higher incidence than on a non-steatosis background. Further investigation showed that apolipoprotein A-I was elevated and accumulated around fatty vacuoles. This elevated level of apolipoprotein A-I was coupled with an elevated level of H-ras12V protein and ROS. In conclusion, our results suggest that the expression of H-ras12V oncogene leads to elevated levels of ROS and apolipoprotein A-I that contribute to steatosis. The steatosis, in turn, promotes the development of hepatic lesions induced by H-ras12V oncogene.
authors: Laboratory Animal Center, Dalian Medical University, Dalian 116044, People's Republic of China. wangaiguotl@hotmail.com
authors: Ai-Guo
authors: AG
authors: Wang
authors: Hyung-Bae
authors: HB
authors: Moon
authors: Jung-Il
authors: JI
authors: Chae
authors: Jin-Man
authors: JM
authors: Kim
authors: Ye-Eun
authors: YE
authors: Kim
authors: Dae-Yeul
authors: DY
authors: Yu
authors: Dong-Seok
authors: DS
authors: Lee