title: Prevalence of the NKG2D Thr72Ala polymorphism in patients with systemic lupus erythematosus.
abstract: Multiple studies have indicated that SLE incidence exhibits a strong genetic background. We studied the frequency of the natural killer group 2, member D (NKG2D) receptor Thr72Ala (rs2255336) polymorphism in patients with SLE (n = 243) and controls (n = 502) in a sample of the Polish population. The p value for SLE patients with the Thr/Thr genotype was 0.0455 and Odds Ratio (OR) = 0.3846 (95% CI = 0.1458-1.014). For the Thr/Thr and Ala/Thr genotypes we found p = 0.0135 and OR = 0.6556 (95% CI = 0.4684-0.9177). The frequency of the NKG2D 72Thr allele in patients and controls was respectively, 15 and 21%, P = 0.0046, OR = 0.6547 (95% CI = 0.4877-0.8789). Our studies may confirm that the NKG2D 72Thr gene variant may protect against the incidence of SLE.
authors: Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Święcickiego St, 60-781 Poznań, Poland.
authors: Piotr
authors: P
authors: Piotrowski
authors: Margarita
authors: M
authors: Lianeri
authors: Marzena
authors: M
authors: Olesińska
authors: Paweł P
authors: PP
authors: Jagodziński
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