title: A case report of a patient with hereditary hemorrhagic telangiectasia treated successively with thalidomide and bevacizumab.
abstract: Hereditary hemorrhagic telangiectasia is characterized by mucocutaneous and visceral telangiectasia and involves several organs with vascular malformations. It is an autosomal dominant disease and is distinguished into three types, which are due to mutations in different genes. The common symptom is anemia, causing a continous need of blood transfusion. Depending on the severity and disease manifestation, there are various forms of therapy ranging from local therapy activities to operations or drug therapy. Here we describe a dramatic improvement of a patient with a high transfusion frequency due to severe recurrent anemia successively treated with thalidomide and bevacizumab.
authors: Department of Gastroenterology and Endocrinology, University Clinic of the Georg August University, Göttingen, Germany.
authors: Ahmad
authors: A
authors: Amanzada
authors: Gwen-Jana
authors: GJ
authors: Töppler
authors: Silke
authors: S
authors: Cameron
authors: Harald
authors: H
authors: Schwörer
authors: Giuliano
authors: G
authors: Ramadori
references: Eur J Gastroenterol Hepatol. 2009 Dec;21(12):1347-50
references: 19730385
references: N Engl J Med. 2009 May 14;360(20):2143-4
references: 19439755
references: N Engl J Med. 2000 Sep 28;343(13):931-6
references: 11006369
references: Am J Med Genet. 1989 Mar;32(3):291-7
references: 2729347
references: Thorax. 1999 Aug;54(8):714-29
references: 10413726
references: Lancet. 1990 Apr 21;335(8695):953-5
references: 1970032
references: Gut. 2004 Apr;53(4):609-12
references: 15016759
references: N Engl J Med. 2009 Aug 27;361(9):931; author reply 931-2
references: 19710496
references: Ann Surg. 2006 Dec;244(6):854-62; discussion 862-4
references: 17122610
references: Dig Dis Sci. 2008 Jun;53(6):1632-5
references: 17990111
references: Proc Natl Acad Sci U S A. 2009 May 26;106(21):8573-8
references: 19433787
references: Am J Med Genet. 2000 Mar 6;91(1):66-7
references: 10751092
references: Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4082-5
references: 7513432
references: Arch Intern Med. 1996 Apr 8;156(7):714-9
references: 8615703
references: Int J Biochem Cell Biol. 2007;39(7-8):1489-99
references: 17369076
references: Nat Genet. 1994 Dec;8(4):345-51
references: 7894484
references: Am J Rhinol. 2007 Mar-Apr;21(2):187-91
references: 17424877
references: World J Gastroenterol. 2007 Dec 7;13(45):5979-84
references: 18023086
references: Laryngoscope. 2010 Feb;120(2):432-5
references: 19998344
references: Nat Genet. 1996 Jun;13(2):189-95
references: 8640225
references: J Hepatol. 2007 Mar;46(3):499-507
references: 17239481
references: N Engl J Med. 1995 Oct 5;333(14):918-24
references: 7666879
references: J Med Genet. 2005 Jul;42(7):577-82
references: 15994879
references: Am J Med Genet. 2000 Aug 14;93(4):320-7
references: 10946360
references: Arch Otolaryngol. 1977 Mar;103(3):148-51
references: 836242
references: Am J Gastroenterol. 1984 May;79(5):363-7
references: 6609633
references: J Laryngol Otol. 1997 Jan;111(1):30-3
references: 9292127
references: Am J Rhinol. 2008 Mar-Apr;22(2):182-7
references: 18416977
references: AJNR Am J Neuroradiol. 2000 Jun-Jul;21(6):1016-20
references: 10871005
references: Liver Transpl. 2008 Feb;14(2):210-3
references: 18236396
references: Ann Hematol. 2006 Sep;85(9):631-2
references: 16807748
references: Oncology (Williston Park). 2002 Jan;16(1):21-4
references: 11831608
references: Haematologica. 2005 Jun;90(6):818-28
references: 15951295
references: Haematologica. 2002 Aug;87(8):ELT34
references: 12161379