title: Effects of nanotopography on stem cell phenotypes.
abstract: Stem cells are unspecialized cells that can self renew indefinitely and differentiate into several somatic cells given the correct environmental cues. In the stem cell niche, stem cell-extracellular matrix (ECM) interactions are crucial for different cellular functions, such as adhesion, proliferation, and differentiation. Recently, in addition to chemical surface modifications, the importance of nanometric scale surface topography and roughness of biomaterials has increasingly becoming recognized as a crucial factor for cell survival and host tissue acceptance in synthetic ECMs. This review describes the influence of nanotopography on stem cell phenotypes.
authors: Rajeswari Ravichandran, Casey K Chan, Michael Raghunath, Division of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117574, Singapore.
authors: Rajeswari
authors: R
authors: Ravichandran
authors: Susan
authors: S
authors: Liao
authors: Clarisse Ch
authors: CCh
authors: Ng
authors: Casey K
authors: CK
authors: Chan
authors: Michael
authors: M
authors: Raghunath
authors: Seeram
authors: S
authors: Ramakrishna
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