title: Enantioselective total synthesis of a natural iridoid.
abstract: The first total synthesis of 6-hydroxy-7-(hydroxymethyl)-4-methylenehexahydrocyclopenta[c]pyran-1(3H)-one has been accomplished. A key feature of the synthesis includes facile construction of the bicyclic lactone intermediate via intramolecular Pd(0)-catalyzed allylic alkylation and the efficient transformation of this intermediate into the iridoid skeleton employing silicon tethered radical cyclization.
authors: College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
authors: Sujin
authors: S
authors: Lee
authors: Seung-Mann
authors: SM
authors: Paek
authors: Hwayoung
authors: H
authors: Yun
authors: Nam-Jung
authors: NJ
authors: Kim
authors: Young-Ger
authors: YG
authors: Suh