title: [Spread of carcinogenic and mutagenic effects in the population of Gornaia Shoria].
abstract: Mutagenic and carcinogenic effects were studied in the population of Gornaya Shoria, Kemerovo Region. The carcinogenic effects were evaluated on the basis of the data given by the Kemerovo regional cancer registry over 1990-2008. The standardized cancer morbidity index in Gornaya Shoria (342 per 100,000 population) exceeded the average index in the Kemerovo Region (286 per 100,000) in the same period. The mutagenic effects were estimated on the basis of the monitoring data on the frequency and spectrum of chromosomal aberrations in the peripheral blood lymphocytes of the dwellers of Gornaya Shoria for the 1992-2009 period. The mean level of chromosomal aberrations (5.31%) in the residents of Gornaya Shoria was found to be greater than the regional background mutation rate (2.86%) (p < 0.001). The values of individual aberration types (chromatid and chromosomal breaks, as well as chromosome-type exchange aberrations) were significantly higher in the dwellers of Gornaya Shoria than those in the basic control group. The revealed high mutagenic load in the inhabitants of Tashtagol District, Kemerovo Region, allows this area to be assigned to high genetic risk ones.
authors: V I
authors: VI
authors: Minina
authors: V G
authors: VG
authors: Druzhinin
authors: T A
authors: TA
authors: Golovina
authors: S A
authors: SA
authors: Larin
authors: S A
authors: SA
authors: Mun
authors: V R
authors: VR
authors: Akhmat'ianova
authors: M L
authors: ML
authors: Bakanova
authors: A N
authors: AN
authors: Glushkov