title: P53 gene alterations in differentiated thyroid cancers.
abstract: Analysis of 22 human thyroid cancers including papillary, follicular and medullary subtypes (PTC, FTC, MTC) by PCR-SSCP, and immunohistochemistry detected 4 deletions and 3 mutations. Deletions involved exons 1, 2-3 and 5-6 in 3 PTCs, mutations exons 2-3 in 2 MTCs and exons 8-9 in PTC4. p53 alterations occurred in 2/5 recurrent tumors and 2/3 tumors developing to cell lines. Immuno-histochemistry detected p53 mutations in differentiated areas of papillary thyroid cancers as frequent events occurring at stage T1 to T4 in contrast to prior findings by other authors which restrict p53 alterations to undifferentiated stages.
authors: SUNY STONY BROOK,DEPT SURG & PATHOL,STONY BROOK,NY 11794. UNIV CHICAGO,SCH MED,DEPT SURG & PATHOL,CHICAGO,IL 60637. HENRY FORD HOSP,DEPT SURG PULM RES & PATHOL,DETROIT,MI 48202. MICHIGAN CANC FDN,MOLEC CANC GENET LABS,DETROIT,MI 48201. ROCHESTER INST TECHNOL,ROCHESTER,NY 14623. UNIV MICHIGAN,SCH MED,DEPT SURG,ANN ARBOR,MI. WAYNE STATE UNIV,CTR MOLEC BIOL,DETROIT,MI. WAYNE STATE UNIV,DEPT ENDOCRINOL,DETROIT,MI. BAY STATE MED CTR,DEPT OBSTET GYNECOL RES,SPRINGFIELD,MA.
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