title: Cross-resistance to antineoplastic agents in a human small-cell lung-cancer subline resistant to okadaic Acid.
abstract: We report on a human small cell lung cancer subline (H69/OA100) resistant to okadaic acid, an inhibitor of protein phosphatases. H69/OA100 showed cross-resistance to cis-diamminedichloroplatinum(II) (CDDP), adriamycin, and vinca alkaloids. Intracellular retention of adriamycin and CDDP in H69/OA100 was the same as those in H69. H69/OA100 was not shown to express MDR-1 by the reverse transcription polymerase chain reaction method. Expression level of mRNA of multidrug resistance-associated protein (MRP) in H69/OA100 was the same as that in H69. These data suggest that the mechanism of drug resistance in H69/OA100 might be due to a new mechanism of non-P-glycoprotein mediated multidrug resistance.
authors: NATL CANC CTR,RES INST,DIV PHARMACOL,CHUO KU,TOKYO 104,JAPAN. NIPPON MED COLL,DEPT INTERNAL MED 4,BUNKYO KU,TOKYO 104,JAPAN.
authors: Y
authors: Y
authors: Takeda
authors: N
authors: N
authors: Kubota
authors: K
authors: K
authors: Nishio
authors: Y
authors: Y
authors: Funayama
authors: A
authors: A
authors: Gemma
authors: H
authors: H
authors: Niitani
authors: N
authors: N
authors: Saijo