title: Bcl-2 and p53 expressions in large-cell lymphoma.
abstract: Bcl-2 and p53 regulate apoptosis in a see-saw fashion and are expressed abnormally in a variety of malignant tumors. We investigated the frequency and prognostic significance of both bcl-2 and p53 expression in 31 large-cell lymphomas. Immunoreaction of bcl-2 and p53 was found in 74% (23/31) and 65% (20/31) of large-cell lymphomas, respectively. Overall survival was not significantly associated with immunoreactivity for either bcl-2 or p53. Frequent association with both p53 and bcl-2 in large-cell lymphomas confirms the existence of a multistep genetic deregulation in lymphomagenesis, but their clinical significance remains to be elucidated in a larger study.
authors: KYUNG HEE UNIV,SCH MED,DEPT INTERNAL MED,SEOUL 130702,SOUTH KOREA. KYUNG HEE UNIV,SCH MED,DEPT PREVENT MED,SEOUL 130702,SOUTH KOREA. KEIMYUNG UNIV,SCH MED,DEPT PATHOL,TAEGU,SOUTH KOREA. UNIV TEXAS,MD ANDERSON CANC CTR,DEPT PATHOL,HOUSTON,TX 77030.
authors: J
authors: J
authors: Lee
authors: S
authors: S
authors: Kim
authors: T
authors: T
authors: Yoon
authors: K
authors: K
authors: Cho
authors: M
authors: M
authors: Yang
authors: S
authors: S
authors: Lee
authors: J
authors: J
authors: Ro