title: Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate retinol-binding protein 4 (RBP4), leptin, and asymmetric dimethylarginine (ADMA) levels in young women with polycystic ovary syndrome (PCOS) and to investigate their relationship with each other and with clinical, metabolic, and hormonal parameters.
  
  
  METHODS
  Clinical study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Fifty-seven young women with PCOS (obese [n = 27] and nonobese [n = 30]) and 27 age-matched healthy controls.
  
  
  METHODS
  History and physical examination, peripheral venous blood sampling.
  
  
  METHODS
  Asymmetric dimethylarginine, RBP4, leptin, LH, FSH, DHEAS, total T, E(2), total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride (TG), and homeostasis model assessment insulin resistance index (HOMA-IR).
  
  
  RESULTS
  Obese women with PCOS had significantly higher HOMA-IR, DHEAS, leptin, RBP4, and ADMA levels. Leptin levels were significantly increased in nonobese subjects with PCOS. Leptin and ADMA levels were positively correlated with HOMA-IR in PCOS. There was no correlation between RBP4 and HOMA-IR. Leptin, RBP4, and ADMA levels are positively correlated in PCOS.
  
  
  CONCLUSIONS
  [1] Young obese women with PCOS have increased ADMA, RBP4, and leptin levels, and they are positively correlated with each other. [2] The increased levels of leptin are independent of obesity, and leptin seems to have an association with IR. [3] Levels of RBP4 may not reflect IR in PCOS.
authors: Department of Obstetrics and Gynecology, Yuzuncu Yil University, Van, Turkey. recepyildizhan@yahoo.com
authors: Recep
authors: R
authors: Yildizhan
authors: Gokce Anik
authors: GA
authors: Ilhan
authors: Begum
authors: B
authors: Yildizhan
authors: Ali
authors: A
authors: Kolusari
authors: Ertan
authors: E
authors: Adali
authors: Guler
authors: G
authors: Bugdayci