title: Combinative growth-inhibitory effects of interferon-alpha and Doxorubicin on multidrug-resistant tumor-cell lines.
abstract: The antiproliferative effects of interferon-alpha (IFN-alpha) and of its combination with doxorubicin (DXR) were studied on three tumor cell lines, the mouse B16 melanoma and Friend erythroleukemia and the human K562 erythroleukemia, both as DXR-sensitive (B16, FLC, K562) and resistant (B16-DXR, FLC-DXR, K562-DXR) variants; the latter lines were endowed with typical multidrug resistance (MDR). Growth inhibition by IFN-alpha was greater in B16-DXR and FLC-DXR than in their chemosensitive counterparts and was superimposable in K562 and K562-DXR. On the other hand, the combination of IFN-alpha and DXR turned out to be merely additive in B16, B16-DXR, K562 and K562-DXR; it was synergistic in FLC and antagonistic in FLC-DXR. Our results and those of others seem to indicate that synergy between IFN-alpha and DXR may occur rarely in MDR cells.
authors: UNIV PALERMO,POLICLIN PAOLO GIACCONE,INST PHARMACOL,I-90127 PALERMO,ITALY.
authors: V
authors: V
authors: Leonardi
authors: N
authors: N
authors: Borsellino
authors: M
authors: M
authors: Crescimanno
authors: C
authors: C
authors: Flandina
authors: A
authors: A
authors: Flugy
authors: N
authors: N
authors: Dalessandro