title: Efficacy of vitrectomy in improving the outcome of Bacillus cereus endophthalmitis.
abstract: OBJECTIVE
  To evaluate the efficacy of vitrectomy with vancomycin for the treatment of experimental Bacillus cereus endophthalmitis.
  
  
  METHODS
  Endophthalmitis was initiated in rabbits via intravitreal injection of 100 colony-forming unit B. cereus. Treatment groups included 25-gauge transconjunctival sutureless vitrectomy with intravitreal vancomycin (1 mg) or vancomycin alone. Groups were treated at 4, 5, or 6 hours after infection. At 48 hours (for 4-hour and 5-hour groups) or 36 hours (for the 6-hour group) after infection, eyes were analyzed by electroretinography, histology, and inflammatory cell counts.
  
  
  RESULTS
  Treatment with vitrectomy/vancomycin at 4 hours resulted in significantly greater retinal function compared with that of vancomycin alone. Intraocular inflammation after treatment at 4 hours was minimal for both the treatment groups. Treatment with vitrectomy/vancomycin or vancomycin alone at 5 hours or 6 hours after infection resulted in similar levels of retinal function loss (i.e., >90%) and significant intraocular inflammation.
  
  
  CONCLUSIONS
  These results demonstrate that vitrectomy may be of therapeutic benefit in the treatment of B. cereus endophthalmitis but only during the early stages of infection.
authors: Department of Ophthalmology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA. michelle-callegan@ouhsc.edu
authors: Michelle C
authors: MC
authors: Callegan
authors: Scott
authors: S
authors: Guess
authors: Nanette R
authors: NR
authors: Wheatley
authors: Dustin C
authors: DC
authors: Woods
authors: Gabe
authors: G
authors: Griffin
authors: Brandt J
authors: BJ
authors: Wiskur
authors: Robert
authors: R
authors: Leonard
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