title: The relation of HLA genotype to hepatitis C viral load and markers of liver fibrosis in HIV-infected and HIV-uninfected women.
abstract: BACKGROUND
  Human leukocyte antigen (HLA) class I and II genotype is associated with clearance of hepatitis C virus (HCV) infection, but little is known regarding its relation with HCV viral load or risk of liver disease in patients with persistent HCV infection.
  
  
  METHODS
  High-resolution HLA class I and II genotyping was conducted in a prospective cohort of 519 human immunodeficiency virus (HIV)-seropositive and 100 HIV-seronegative women with persistent HCV infection. The end points were baseline HCV viral load and 2 noninvasive indexes of liver disease, fibrosis-4 (FIB-4), and the aspartate aminotransferase to platelet ratio index (APRI), measured at baseline and prospectively.
  
  
  RESULTS
  DQB1*0301 was associated with low baseline HCV load (β = -.4; 95% confidence interval [CI], -.6 to -.3; P < .00001), as well as with low odds of FIB-4-defined (odds ratio [OR], .5; 95% CI, .2-.9; P = .02) and APRI-defined liver fibrosis (OR, .5; 95% CI, .3-1.0; P = .06) at baseline and/or during follow-up. Most additional associations with HCV viral load also involved HLA class II alleles. Additional associations with FIB-4 and APRI primarily involved class I alleles, for example, the relation of B*1503 with APRI-defined fibrosis had an OR of 2.0 (95% CI, 1.0-3.7; P = .04).
  
  
  CONCLUSIONS
  HLA genotype may influence HCV viral load and risk of liver disease, including DQB1*0301, which was associated with HCV clearance in prior studies.
authors: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA. mark.kuniholm@einstein.yu.edu
authors: Mark H
authors: MH
authors: Kuniholm
authors: Xiaojiang
authors: X
authors: Gao
authors: Xiaonan
authors: X
authors: Xue
authors: Andrea
authors: A
authors: Kovacs
authors: Darlene
authors: D
authors: Marti
authors: Chloe L
authors: CL
authors: Thio
authors: Marion G
authors: MG
authors: Peters
authors: Ruth M
authors: RM
authors: Greenblatt
authors: James J
authors: JJ
authors: Goedert
authors: Mardge H
authors: MH
authors: Cohen
authors: Howard
authors: H
authors: Minkoff
authors: Stephen J
authors: SJ
authors: Gange
authors: Kathryn
authors: K
authors: Anastos
authors: Melissa
authors: M
authors: Fazzari
authors: Mary A
authors: MA
authors: Young
authors: Howard D
authors: HD
authors: Strickler
authors: Mary
authors: M
authors: Carrington
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