title: Endothelial progenitor cell biology in disease and tissue regeneration.
abstract: Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marrow niche to sites of inflammation and tumor to induce neovasculogenesis has afforded a novel opportunity to understand the tissue microenvironment and specific cell-cell interactive pathways. This review provides a comprehensive up-to-date understanding of the physiological function and therapeutic utility of these cells. The emphasis is on the systemic factors that modulate their differentiation/mobilization and survival and presents the challenges of its potential therapeutic clinical utility as a diagnostic and prognostic reagent.
authors: Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.
authors: Andrea L
authors: AL
authors: George
authors: Pradeep
authors: P
authors: Bangalore-Prakash
authors: Shilpi
authors: S
authors: Rajoria
authors: Robert
authors: R
authors: Suriano
authors: Arulkumaran
authors: A
authors: Shanmugam
authors: Abraham
authors: A
authors: Mittelman
authors: Raj K
authors: RK
authors: Tiwari
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