title: Thyroid hormone action in metabolic regulation.
abstract: Thyroid hormone plays pivotal roles in growth, differentiation, development and metabolic homeostasis via thyroid hormone receptors (TRs) by controlling the expression of TR target genes. The transcriptional activity of TRs is modulated by multiple factors including various TR isoforms, diverse thyroid hormone response elements, different heterodimeric partners, coregulators, and the cellular location of TRs. In the present review, we summarize recent advance in understanding the molecular mechanisms of thyroid hormone action obtained from human subject research, thyroid hormone mimetics application, TR isoform-specific knock-in mouse models, and mitochondrion study with highlights in metabolic regulations. Finally, as future perspectives, we share our thoughts about current challenges and possible approaches to promote our knowledge of thyroid hormone action in metabolism.
authors: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China.
authors: Yiyun
authors: Y
authors: Song
authors: Xuan
authors: X
authors: Yao
authors: Hao
authors: H
authors: Ying
references: Mol Cell Endocrinol. 1995 Jan;107(1):55-66
references: 7796935
references: Nature. 1988 Aug 11;334(6182):539-42
references: 2841611
references: Mol Cell Biol. 2001 May;21(9):2991-3000
references: 11287605
references: Endocrinology. 1992 Feb;130(2):1077-9
references: 1733708
references: Thyroid. 2008 Feb;18(2):141-4
references: 18279014
references: Endocrinology. 2005 Jul;146(7):2872-84
references: 15845618
references: J Biol Chem. 1994 Apr 22;269(16):11683-6
references: 8163464
references: Cell. 2008 Jul 11;134(1):112-23
references: 18614015
references: J Biol Chem. 1995 Jul 7;270(27):16347-54
references: 7608204
references: Steroids. 2007 Feb;72(2):171-9
references: 17169389
references: Endocrinology. 2010 Jan;151(1):432-40
references: 19906816
references: FEBS Lett. 1997 Oct 27;416(3):291-6
references: 9373172
references: Receptor. 1993 Fall;3(3):183-91
references: 8167569
references: J Biol Chem. 2003 Oct 3;278(40):38913-20
references: 12869545
references: J Biol Chem. 2010 Sep 3;285(36):28156-63
references: 20615868
references: Biochem Biophys Res Commun. 1994 Apr 15;200(1):619-26
references: 8166737
references: Rev Endocr Metab Disord. 2000 Jan;1(1-2):49-58
references: 11704992
references: J Clin Invest. 2001 Jul;108(1):97-105
references: 11435461
references: Diabetes. 2002 Apr;51(4):1022-7
references: 11916921
references: Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15095-100
references: 11734632
references: J Clin Invest. 2001 Sep;108(5):733-7
references: 11544279
references: EMBO J. 2007 Oct 31;26(21):4535-45
references: 17932484
references: Am J Physiol. 1989 Jan;256(1 Pt 1):E159-66
references: 2643338
references: Nature. 1994 Aug 4;370(6488):382-6
references: 8047145
references: Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):349-54
references: 11120878
references: Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):439-43
references: 8290545
references: Genome Biol. 2002;3(12):REVIEWS3015
references: 12537581
references: Nature. 1995 Dec 14;378(6558):690-7
references: 7501015
references: Behav Brain Res. 2007 Feb 12;177(1):109-16
references: 17129617
references: J Clin Endocrinol Metab. 2007 Feb;92(2):491-6
references: 17090642
references: Genes Dev. 2005 Sep 15;19(18):2152-63
references: 16131613
references: Cell. 1999 Jul 9;98(1):115-24
references: 10412986
references: J Endocrinol. 1970 Jun;47(2):257-8
references: 5431696
references: J Appl Physiol (1985). 2001 Apr;90(4):1267-74
references: 11247923
references: Nature. 1986 Dec 18-31;324(6098):641-6
references: 2879243
references: Nature. 1995 Oct 5;377(6548):397-404
references: 7566114
references: Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9913-8
references: 11481455
references: Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16251-6
references: 16260719
references: Mol Psychiatry. 2003 Jan;8(1):30-8
references: 12556906
references: J Clin Invest. 2003 Aug;112(4):588-97
references: 12925699
references: J Clin Invest. 1970 May;49(5):855-64
references: 4986007
references: Thyroid. 2008 Feb;18(2):145-56
references: 18279015
references: Nature. 1986 Dec 18-31;324(6098):635-40
references: 2879242
references: J Clin Endocrinol Metab. 1988 Mar;66(3):565-9
references: 3280588
references: Rev Endocr Metab Disord. 2000 Jan;1(1-2):9-18
references: 11704997
references: Mol Endocrinol. 1992 Mar;6(3):429-42
references: 1316541
references: J Clin Invest. 1991 Jan;87(1):125-32
references: 1985090
references: Physiol Rev. 2001 Jul;81(3):1097-142
references: 11427693
references: J Biol Chem. 2000 Nov 10;275(45):34989-97
references: 10956641
references: J Clin Endocrinol Metab. 2009 Sep;94(9):3521-9
references: 19549744
references: Endocrinology. 1992 Mar;130(3):1539-46
references: 1537303
references: J Clin Invest. 1991 Dec;88(6):2123-30
references: 1661299
references: J Biol Chem. 1997 Feb 14;272(7):4129-34
references: 9020124
references: Trends Endocrinol Metab. 2003 Mar;14(2):85-90
references: 12591179
references: Thyroid. 1997 Jun;7(3):463-9
references: 9226220
references: Nat Biotechnol. 2008 Mar;26(3):343-51
references: 18297058
references: J Clin Endocrinol Metab. 1985 Dec;61(6):1165-71
references: 3840492
references: Nat Genet. 1996 Jul;13(3):354-7
references: 8673137
references: Nature. 1995 Oct 5;377(6548):454-7
references: 7566127
references: Proc Natl Acad Sci U S A. 1988 Aug;85(16):5804-8
references: 2901090
references: Endocr Rev. 1999 Jun;20(3):321-44
references: 10368774
references: Am J Physiol. 1994 Aug;267(2 Pt 1):E273-7
references: 8074207
references: Endocrinology. 1997 Apr;138(4):1456-63
references: 9075702
references: Cell. 1997 May 2;89(3):373-80
references: 9150137
references: EMBO J. 2002 Oct 1;21(19):5079-87
references: 12356724
references: Diabetologia. 2005 Apr;48(4):624-33
references: 15756538
references: Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14104-9
references: 16966610
references: Metabolism. 1995 Nov;44(11):1380-3
references: 7476321
references: Mol Endocrinol. 2005 Dec;19(12):2955-63
references: 16051672
references: Science. 1989 Apr 7;244(4900):76-9
references: 2539642
references: Mol Cell Biol. 1999 Dec;19(12):7913-24
references: 10567517
references: Biochem Soc Trans. 2005 Nov;33(Pt 5):897-904
references: 16246006
references: EMBO J. 1996 Oct 1;15(19):5336-48
references: 8895578
references: Mol Endocrinol. 2009 Mar;23(3):308-15
references: 19131509
references: Nat Med. 2010 Sep;16(9):1001-8
references: 20802499
references: J Clin Endocrinol Metab. 2006 Dec;91(12):4930-7
references: 17003097
references: Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4471-6
references: 20160073
references: Am J Physiol. 1999 Jan;276(1):E179-87
references: 9886965
references: Endocrinology. 1995 Aug;136(8):3267-76
references: 7628360
references: Biochem J. 1979 Aug 15;182(2):565-75
references: 508297
references: J Clin Invest. 1990 Jan;85(1):101-5
references: 2153150
references: Mol Cell Endocrinol. 2008 Jun 11;287(1-2):1-12
references: 18448240
references: Mol Cell Biol. 2007 Mar;27(6):2359-71
references: 17220280
references: Mol Cell Biochem. 2000 Jul;210(1-2):47-52
references: 10976757
references: Diabetologia. 1999 Jan;42(1):113-6
references: 10027589
references: Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14
references: 11069286
references: J Biol Chem. 1992 Feb 15;267(5):3358-67
references: 1737790
references: Endocrinology. 2009 Jul;150(7):3417-24
references: 19324998
references: J Clin Endocrinol Metab. 1996 Aug;81(8):2768-72
references: 8768826