title: Improved detectability of small-bowel lesions via capsule endoscopy with computed virtual chromoendoscopy: a pilot study.
abstract: OBJECTIVE
  Real-time video capsule endoscopy (CE) with flexible spectral imaging color enhancement (FICE) improves visibility of small-bowel lesions. This article aims to clarify whether CE-FICE also improves detectability of small-bowel lesions.
  
  
  METHODS
  A total of 55 patients who underwent CE at Hiroshima University Hospital during the period November 2009 through March 2010 were enrolled in the study. Five patients were excluded from the study because residues and transit delays prevented sufficient evaluation. Thus, 50 patients participated. Two experienced endoscopists (each having interpreted more than 50 capsule videos) analyzed the images. One interpreted conventional capsule videos; the other, blinded to interpretation of the conventional images, interpreted CE-FICE images obtained at settings 1-3 (setting 1: red 595 nm, green 540 nm, blue 535 nm; setting 2: red 420 nm, green 520 nm, blue 530 nm; setting 3: red 595 nm, green 570 nm, blue 415 nm). Lesions were classified as angioectasia, erosion, ulceration, or tumor. Detectability was compared between the two modalities. Time taken to interpret the capsule videos was also determined.
  
  
  RESULTS
  Seventeen angioectasias were identified by conventional CE; 48 were detected by CE-FICE at setting 1, 45 at setting 2, and 24 at setting 3, with significant differences at settings 1 and 2 (p = 0.0003, p < 0.0001, respectively). Detection of erosion, ulceration, and tumor did not differ statistically between conventional CE and CE-FICE, nor did interpretation time (conventional CE 36 ± 6.9 min; CE-FICE setting 1, 36 ± 6.4 min; setting 2, 38 ± 5.8 min; setting 3, 35 ± 6.7 min).
  
  
  CONCLUSIONS
  CE-FICE is superior in the lesion detection in comparison with conventional CE and improves detection of angioectasia.
authors: Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan.
authors: Hiroki
authors: H
authors: Imagawa
authors: Shiro
authors: S
authors: Oka
authors: Shinji
authors: S
authors: Tanaka
authors: Ikue
authors: I
authors: Noda
authors: Makoto
authors: M
authors: Higashiyama
authors: Youji
authors: Y
authors: Sanomura
authors: Takayoshi
authors: T
authors: Shishido
authors: Shigeto
authors: S
authors: Yoshida
authors: Kazuaki
authors: K
authors: Chayama
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