title: No effect of physiotherapy on the serum levels of adipocytokines in patients with ankylosing spondylitis.
abstract: To investigate the effect of intensive physiotherapy on disease activity and serum levels of adipocytokines in patients with ankylosing spondylitis (AS). Twenty-six patients with AS were included in this study. Intensive physiotherapy was performed twice a week for a period of 3 months. The Bath AS Disease Activity Index (BASDAI) and the Bath AS Functional Index (BASFI) were assessed at inclusion and after 3 months. Leptin, adiponectin, resistin and visfatin serum levels were analysed by ELISA assays. Patients had mild to moderate disease activity. Baseline levels of adipocytokines did not correlate with indicators of disease activity, functional status or acute-phase reactants. After the 3 months of intensive physiotherapy, BASDAI significantly decreased from 2.98 to 1.8 (p = 0.01) and BASFI improved from 2.31 to 1.37 (p = 0.05), while there were no changes in serum levels of CRP, ESR and adipocytokines. In addition, baseline levels of adipocytokines did not predict the change of disease activity or functional ability. Intensive physiotherapy effectively reduces all clinical measures of disease activity, but it is not associated with a significant change in acute-phase reactants or serum levels of adipocytokines.
authors: Institute of Rheumatology, Department of Experimental and Clinical Rheumatology, Prague, Czech Republic. hule@revma.cz
authors: Hana
authors: H
authors: Hulejová
authors: Andrea
authors: A
authors: Levitová
authors: Markéta
authors: M
authors: Kuklová
authors: Jan
authors: J
authors: Stochl
authors: Martin
authors: M
authors: Haluzík
authors: Karel
authors: K
authors: Pavelka
authors: Jiří
authors: J
authors: Vencovský
authors: Ladislav
authors: L
authors: Senolt
references: J Rheumatol. 1994 Dec;21(12):2286-91
references: 7699630
references: J Immunol. 2005 May 1;174(9):5789-95
references: 15843582
references: Ann Rheum Dis. 2006 Sep;65(9):1198-201
references: 16414972
references: J Immunol. 2006 Apr 1;176(7):4468-78
references: 16547285
references: Ann Rheum Dis. 2007 Apr;66(4):458-63
references: 17040961
references: Clin Rheumatol. 2008 Jun;27(6):695-700
references: 17985194
references: Arthritis Rheum. 2007 Sep;56(9):2829-39
references: 17763446
references: J Rheumatol. 2002 Apr;29(4):763-6
references: 11950019
references: Ann Rheum Dis. 2003 Oct;62(10):952-6
references: 12972473
references: Obesity (Silver Spring). 2009 Jun;17(6):1189-95
references: 19247279
references: Med Sci Sports Exerc. 2010 Mar;42(3):456-62
references: 19952805
references: Endocr Regul. 2010 Jan;44(1):25-36
references: 20151765
references: Nat Clin Pract Rheumatol. 2008 Nov;4(11):597-604
references: 18839010
references: Lancet. 2007 Apr 21;369(9570):1379-1390
references: 17448825
references: Metabolism. 2007 Oct;56(10):1383-9
references: 17884449
references: Trends Cardiovasc Med. 2007 Nov;17(8):275-83
references: 18021938
references: Rheumatology (Oxford). 2006 Mar;45(3):283-6
references: 16204374
references: J Rheumatol. 1994 Dec;21(12):2281-5
references: 7699629
references: J Rheumatol. 2005 Oct;32(10):1899-906
references: 16206344
references: Arthritis Rheum. 1984 Apr;27(4):361-8
references: 6231933
references: Curr Opin Rheumatol. 2008 Mar;20(2):203-7
references: 18349752
references: Scand J Rheumatol. 2007 Mar-Apr;36(2):101-6
references: 17476615
references: Cytokine. 2006 Sep;35(5-6):247-52
references: 17079158
references: Clin Immunol. 2009 Nov;133(2):157-70
references: 19740705
references: Ann Rheum Dis. 2003 Sep;62(9):817-24
references: 12922952
references: J Am Coll Cardiol. 2005 May 17;45(10):1563-9
references: 15893167
references: Nat Rev Immunol. 2006 Oct;6(10):772-83
references: 16998510