title: Concise total synthesis of calothrixins A and B.
abstract: The concise total synthesis of calothrixins A and B has been accomplished by utilizing the one-pot formation of hexatriene as a key intermediate via the palladium-catalyzed tandem cyclization/cross-coupling reaction of triethyl(indol-2-yl)borate. In another key transformation, the indolo[3,2-j]phenanthridine core was prepared in high yield via Cu(I)-mediated 6π-electrocyclization.
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Abe
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ikeda
authors.forename: Reiko
authors.initials: R
authors.lastname: Yanada
authors.forename: Minoru
authors.initials: M
authors.lastname: Ishikura
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D026121:Indole Alkaloids; C418328:calothrixin A; C418327:calothrixin B; D010165:Palladium; D003300:Copper