title: Mucinous cystadenoma coexisting with adult granulosa cell tumor in the ovary: is it a composite tumor or heterologous mucinous elements in a granulosa cell tumor?
abstract: We herein report a rare tumor combination of mucinous cystadenoma and an adult granulosa cell tumor in the same ovary of a 50-year-old woman. Ultrasound examination showed a multicystic mass in the left ovary. Histologically it showed 2 components that were intimately admixed. One was composed of cysts lined by mucinous epithelium of the intestinal type that was strongly positive for cytokeratin-20 and cytokeratin-7. The other was a granulosa cell tumor of the adult type in which the tumor cells showed microfollicular, sheets, and trabecular patterns. They were positive for calretinin, α-inhibin, and CD99. There are many theories for the histogenesis of such a combination. After discussing all the possibilities we conclude that the mucinous component is probably a heterologous mucinous differentiation within an adult granulosa cell tumor because of the intimate admixture of the 2 components and the mucinous epithelium being of the intestinal type.
authors.affiliation: Department of Histopathology, Faculty of Medicine, Kuwait University, Kuwait. nageshbabu_s1@rediffmail.com
authors.forename: Nagesh Babu
authors.initials: NB
authors.lastname: Subrahmanya
authors.forename: Surendra Nayak
authors.initials: SN
authors.lastname: Kapadi
authors.forename: Thamradeen A
authors.initials: TA
authors.lastname: Junaid
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000032:analysis; D064032:Calbindin 2; D015815:Cell Adhesion Molecules / Q000032:analysis; D018291:Cystadenoma, Mucinous / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007265:Inhibins / Q000032:analysis; D053537:Keratin-17 / Q000032:analysis; D053554:Keratin-20 / Q000032:analysis; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology*; D064030:S100 Calcium Binding Protein G / Q000032:analysis
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C576764:CALB2 protein, human; C061828:CD99 protein, human; D064032:Calbindin 2; D015815:Cell Adhesion Molecules; D053537:Keratin-17; D053554:Keratin-20; D064030:S100 Calcium Binding Protein G; C094377:inhibin-alpha subunit; D007265:Inhibins