title: Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy.
abstract: Many genes have been associated with radiotherapy toxicity, but most have only been found in a single study. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.
authors.affiliation: Department of Genetics, University of Leicester, UK.
authors.forename: Robert J S
authors.initials: RJ
authors.lastname: Murray
authors.forename: George A
authors.initials: GA
authors.lastname: Tanteles
authors.forename: Jamie
authors.initials: J
authors.lastname: Mills
authors.forename: Angus
authors.initials: A
authors.lastname: Perry
authors.forename: Irene
authors.initials: I
authors.lastname: Peat
authors.forename: Ahmed
authors.initials: A
authors.lastname: Osman
authors.forename: Steve
authors.initials: S
authors.lastname: Chan
authors.forename: Kwok-Leung
authors.initials: KL
authors.lastname: Cheung
authors.forename: Prabir R
authors.initials: PR
authors.lastname: Chakraborti
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Woodings
authors.forename: Julian G
authors.initials: JG
authors.lastname: Barwell
authors.forename: R Paul
authors.initials: RP
authors.lastname: Symonds
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Talbot
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000532:radiotherapy* / Q000601:surgery; D018797:Cell Cycle Proteins / Q000235:genetics / Q000528:radiation effects; D016009:Chi-Square Distribution; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000235:genetics* / Q000528:radiation effects*; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007564:Japan; D016014:Linear Models; D009363:Neoplasm Proteins / Q000235:genetics / Q000528:radiation effects; D010641:Phenotype; D000075223:Poly-ADP-Ribose Binding Proteins; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D011832:Radiation Injuries / Q000235:genetics*; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D064249:Securin; D012867:Skin / Q000528:radiation effects*; D018709:Statistics, Nonparametric; D029867:Xenopus Proteins
chemical_list: D018797:Cell Cycle Proteins; D009363:Neoplasm Proteins; D000075223:Poly-ADP-Ribose Binding Proteins; D064249:Securin; D029867:Xenopus Proteins; C069930:rad9 protein; D011088:DNA Ligases; D000072481:DNA Ligase ATP; C000618816:DNA ligase III alpha protein, Xenopus; C000618817:LIG3 protein, human