title: Tuberculosis cutis orificialis with both gingival involvement and underlying pulmonary tuberculosis.
abstract: Tuberculosis cutis orificialis is a rare manifestation of cutaneous tuberculosis which occurs in the oral, perianal and adjacent mucosa. The most frequent orificial lesion location is the tongue. We report a case of a 35-year-old female with tuberculosis cutis orificialis with gingival involvement. She had a six-month history of a moderately painful gingival ulceration. Histopathological examination showed granulomatous infiltrates composed of epithelioid cells, Langhans giant cells and caseating necrosis. A purified protein derivative test was positive. Sputum culture was positive for Mycobacterium tuberculosis. Chest X-ray and high resolution computed tomography showed active pulmonary tuberculosis in both upper lung zones. The gingival specimen was positive for M. tuberculosis polymerase chain reaction. A complete resolution was achieved after six months of anti-tuberculosis therapy. Dental identification of M. tuberculosis may serve as an important aid in the first line of control of this dangerous infectious disease.
authors.affiliation: Department of Oral Medicine and Periodontology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, China.
authors.forename: W-L
authors.initials: WL
authors.lastname: Sun
authors.forename: K-L
authors.initials: KL
authors.lastname: Xu
authors.forename: L-L
authors.initials: LL
authors.lastname: Chen
authors.forename: Z-S
authors.initials: ZS
authors.lastname: Yu
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D005260:Female; D005882:Gingival Diseases / Q000382:microbiology*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D019226:Oral Ulcer / Q000382:microbiology; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D014375:Tuberculoma / Q000382:microbiology; D014393:Tuberculosis, Oral / Q000175:diagnosis*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis
chemical_list: D000995:Antitubercular Agents