title: Metabolic derangements seen in chronic kidney disease and end-stage renal disease patients.
abstract: The National Health and Nutrition Examination Survey (NHANES) shows increasing trends in the prevalence of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in the US population. There is an inverse relationship between a declining glomerular filtration rate and mortality and morbidity. A wide spectrum of complex metabolic derangements contributes to a large extent for this increased mortality and morbidity. An overview of some of these metabolic derangements--like uremic dyslipidemia, uremic inflammation, and endocrine abnormalities affecting thyroid and sexual functioning of CKD patients--is provided. Understanding some of these metabolic derangements may help develop new and affective strategies to help reduce mortality and morbidity among CKD patients.
authors.forename: Diptesh
authors.initials: D
authors.lastname: Gupta
authors.forename: Madhukar
authors.initials: M
authors.lastname: Misra
mesh_terms: D002908:Chronic Disease; D006801:Humans; D007333:Insulin Resistance; D007674:Kidney Diseases / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D050356:Lipid Metabolism; D011502:Protein-Energy Malnutrition / Q000209:etiology; D012735:Sexual Dysfunction, Physiological / Q000209:etiology; D013959:Thyroid Diseases / Q000209:etiology