title: On the utility of S-mesitylsulfinimines for the stereoselective synthesis of chiral amines and aziridines.
abstract: The synthetic utility of S-mesitylsulfinimines for the synthesis of chiral amines and aziridines was examined through their reactions with Grignard reagents, with the ylides derived from trimethylsulfonium iodide and S-allyl-tetrahydrothiophenium bromide and through an aza-Darzens manifold, affording convenient access to a diverse range of highly substituted chiral amines and aziridines in high yields and excellent stereoselectivities.
authors.affiliation: School of Chemistry, University of Nottingham, Nottingham, NG7 2RD.
authors.forename: Caroline
authors.initials: C
authors.lastname: Roe
authors.forename: Toni
authors.initials: T
authors.lastname: Moragas Solá
authors.forename: Leonid
authors.initials: L
authors.lastname: Sasraku-Neequaye
authors.forename: Heather
authors.initials: H
authors.lastname: Hobbs
authors.forename: Ian
authors.initials: I
authors.lastname: Churcher
authors.forename: David
authors.initials: D
authors.lastname: MacPherson
authors.forename: Robert A
authors.initials: RA
authors.lastname: Stockman
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity; D013452:Sulfonium Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D001388:Aziridines; D007097:Imines; D007202:Indicators and Reagents; D013452:Sulfonium Compounds; C522016:sulfinimine