title: A fatal central nervous system enterovirus 68 infection.
abstract: The anticipated eradication of poliovirus emphasizes the need to identify other enteroviral causes of severe central nervous system disease. Enterovirus 68 has been implicated only in cases of respiratory illness. We therefore report a case of fatal meningomyeloencephalitis caused by enterovirus 68 in a 5-year-old boy, which required neuropathology, microbiology, and molecular techniques to diagnose.
authors.affiliation: Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA. justin.d.kreuter@hitchcock.org
authors.forename: Justin D
authors.initials: JD
authors.lastname: Kreuter
authors.forename: Arti
authors.initials: A
authors.lastname: Barnes
authors.forename: James E
authors.initials: JE
authors.lastname: McCarthy
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Schwartzman
authors.forename: M Steven
authors.initials: MS
authors.lastname: Oberste
authors.forename: C Harker
authors.initials: CH
authors.lastname: Rhodes
authors.forename: John F
authors.initials: JF
authors.lastname: Modlin
authors.forename: Peter F
authors.initials: PF
authors.lastname: Wright
mesh_terms: D000208:Acute Disease; D001929:Brain Edema / Q000473:pathology / Q000821:virology; D020805:Central Nervous System Viral Diseases / Q000175:diagnosis* / Q000821:virology; D002675:Child, Preschool; D004679:Encephalomyelitis / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000821:virology; D030016:Enterovirus D, Human / Q000235:genetics / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000175:diagnosis* / Q000821:virology; D017809:Fatal Outcome; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000821:virology; D011014:Pneumonia / Q000473:pathology; D012367:RNA, Viral / Q000032:analysis; D013116:Spinal Cord / Q000473:pathology
chemical_list: D012367:RNA, Viral