title: Calcium binding protein-mediated regulation of voltage-gated calcium channels linked to human diseases.
abstract: Calcium ion entry through voltage-gated calcium channels is essential for cellular signalling in a wide variety of cells and multiple physiological processes. Perturbations of voltage-gated calcium channel function can lead to pathophysiological consequences. Calcium binding proteins serve as calcium sensors and regulate the calcium channel properties via feedback mechanisms. This review highlights the current evidences of calcium binding protein-mediated channel regulation in human diseases.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Toronto, 3306 MSB, 1 King's College Circle, Toronto, Ontario, Canada.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Nejatbakhsh
authors.forename: Zhong-ping
authors.initials: ZP
authors.lastname: Feng
mesh_terms: D000818:Animals; D020746:Calcium Channels, L-Type / Q000235:genetics / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004194:Disease / Q000209:etiology* / Q000235:genetics; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D008268:Macular Degeneration / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D020325:Migraine with Aura / Q000209:etiology / Q000235:genetics / Q000378:metabolism
chemical_list: D020746:Calcium Channels, L-Type; D002135:Calcium-Binding Proteins