title: Impact of contrast enhanced MRI on lymphocyte DNA damage and serum visfatin level.
abstract: OBJECTIVE
  Nephrogenic systemic fibrosis is a novel clinical entity encountered in subjects undergoing contrast enhanced magnetic resonance imaging (MRI). The aim of the present study is to evaluate the impact of contrast enhanced MRI exposure on lymphocyte DNA damage and serum levels of visfatin.
  
  
  METHODS
  Twenty-eight subjects undergoing contrast enhanced hypophysial MRI with omniscan were included in the study. Blood samples were drawn before MRI, after non-contrast MRI and after contrast enhanced MRI from each subject. Lymphocyte DNA damage was analyzed by the alkaline comet assay, whereas serum visfatin level was assessed with enzyme immuno assay.
  
  
  RESULTS
  Both lymphocyte DNA damage and serum visfatin levels were statistically significantly increased in samples withdrawn after contrast enhanced MRI compared to samples withdrawn after non-contrast enhanced MRI and baseline samples (ANOVA p<0.001, for both).
  
  
  CONCLUSIONS
  Findings of the present study revealed that the contrast enhanced MRI is associated with increased lymphocyte DNA damage and increased serum visfatin level.
authors.affiliation: Harran University School of Medicine, Department of Radiology, 63100, Sanliurfa, Turkey. drsemayildiz@yahoo.com
authors.forename: Sema
authors.initials: S
authors.lastname: Yildiz
authors.forename: Hasan
authors.initials: H
authors.lastname: Cece
authors.forename: Ihsan
authors.initials: I
authors.lastname: Kaya
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskin
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.forename: Abdurrahim
authors.initials: A
authors.lastname: Kocyigit
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Eren
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D003287:Contrast Media / Q000009:adverse effects*; D004249:DNA Damage; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008279:Magnetic Resonance Imaging / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D055815:Young Adult
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D002097:C-Reactive Protein; D054409:Nicotinamide Phosphoribosyltransferase; D019786:Gadolinium DTPA