title: Successful use of a pneumatic biventricular assist device as a bridge to transplantation in cardiogenic shock.
abstract: BACKGROUND
  Mechanical circulatory support is a highly effective technology to maintain organ perfusion in patients with cardiogenic shock as a bridge to transplantation. Although implantation of a left ventricular assist device alone is often the preferred configuration, patients with biventricular failure and significant end-organ dysfunction often require biventricular assistance.
  
  
  METHODS
  Between January 2000 and September 2008, 80 patients with severe biventricular failure were accepted for heart transplantation and received a pneumatic biventricular assist devices as a bridge to transplant. Patients were retrospectively divided into 2 groups: those successfully bridged to transplant (Group A) and those who died (Group B). Patients were also divided into 2 periods of implantation: Group X (2000-2005) and Group Y (2006-2008, which used a multidiscipline selection process).
  
  
  RESULTS
  Overall success rate to transplantation was 71.3%, with Group Y demonstrating an 82% success to transplant rate vs 63% in Group X. One-year actuarial survival after transplant was 89% compared with 92% in patients without a ventricular assist device. There were no statistically significant laboratory parameters between Groups A and B identifying potential risk factors for poor outcome.
  
  
  CONCLUSIONS
  Biventricular assist device therapy represents an effective and reliable means of supporting selected Interagency Registry for Mechanically Assisted Circulatory Support profile 1 patients as a bridge to transplantation, with excellent success to transplant rates and post-transplant survival.
authors.affiliation: Cedars-Sinai Heart Institute, Los Angeles, California, USA. Jaime.Moriguchi@cshs.org
authors.forename: Jaime
authors.initials: J
authors.lastname: Moriguchi
authors.forename: Stephanie
authors.initials: S
authors.lastname: Davis
authors.forename: Rhodora
authors.initials: R
authors.lastname: Jocson
authors.forename: Fardad
authors.initials: F
authors.lastname: Esmailian
authors.forename: Abbas
authors.initials: A
authors.lastname: Ardehali
authors.forename: Hillel
authors.initials: H
authors.lastname: Laks
authors.forename: Murray
authors.initials: M
authors.lastname: Kwon
authors.forename: Michelle
authors.initials: M
authors.lastname: Kittleson
authors.forename: Jon
authors.initials: J
authors.lastname: Kobashigawa
authors.forename: Jignesh
authors.initials: J
authors.lastname: Patel
authors.forename: Daniel
authors.initials: D
authors.lastname: Marelli
authors.forename: Mark
authors.initials: M
authors.lastname: Plunkett
authors.forename: Ramin
authors.initials: R
authors.lastname: Beygui
authors.forename: Richard
authors.initials: R
authors.lastname: Shemin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015199:Extracorporeal Membrane Oxygenation / Q000706:statistics & numerical data; D005260:Female; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006801:Humans; D007423:Intra-Aortic Balloon Pumping / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D012770:Shock, Cardiogenic / Q000601:surgery*; D055815:Young Adult