title: [Recent advance in the genomic study for osteoarthritis].
abstract: Osteoarthritis (OA) is a polygenic disease. Genetic factors are involved in its onset and progression. Identification of its genetic factor, i.e., the susceptibility genes for OA is rapidly in progress by using genomic approaches including genome-wide association study. Recent advance in the study of OA susceptibility genes is reviewed.
authors.affiliation: Laboratory for Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
mesh_terms: D000818:Animals; D024142:Collagen Type VI / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D055428:Growth Differentiation Factor 5 / Q000235:genetics; D006801:Humans; D051379:Mice; D010003:Osteoarthritis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011544:Pseudogenes
chemical_list: C439889:ASPN protein, human; C531065:COL6A4P1 protein, human; D024142:Collagen Type VI; D016326:Extracellular Matrix Proteins; C525893:GDF5 protein, human; D055428:Growth Differentiation Factor 5