title: H2AFX polymorphisms are associated with decreased risk of diffuse large B cell lymphoma in Koreans.
abstract: Polymorphisms of the H2A histone family member X (H2AFX) gene have been associated with decreased non-Hodgkin lymphoma (NHL, -417AA) risk and increased breast cancer (1654AG/GG, and -1420GA/AA) risk. We investigated whether H2AFX polymorphisms are associated with the risk of NHL and its subtypes in 573 NHL Korean patients and 721 cancer-free control subjects, using high resolution melting polymerase chain reaction and an automatic sequencer. There was no association between polymorphisms and the risk of overall NHL, all B cell lymphoma, or all T cell lymphoma. However, the -1420 AA genotype was associated with decreased diffuse large B cell lymphoma (DLBCL) risk (OR, 0.65; 95% CI, 0.43-0.97), and there was a trend for allele dose-effect (p-trend=0.03). The -1187 CC genotype was associated with decreased DLBCL risk with borderline significance (OR, 0.70; 95% CI, 0.48-1.02). There was a trend for an allele dose-effect with borderline significance (p-trend=0.06). These results suggest that the -1420 AA genotype of H2AFX may be associated with reduced DLBCL risks in the Korean population.
authors.affiliation: Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun-gun, Chonnam, Republic of Korea.
authors.forename: Xue Mei
authors.initials: XM
authors.lastname: Jin
authors.forename: Hee Nam
authors.initials: HN
authors.lastname: Kim
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
authors.forename: Il-Kwon
authors.initials: IK
authors.lastname: Lee
authors.forename: Ji Shin
authors.initials: JS
authors.lastname: Lee
authors.forename: Jae-Hyuk
authors.initials: JH
authors.lastname: Lee
authors.forename: Hyeoung-Joon
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Juhng
authors.forename: Chan
authors.initials: C
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001665:Binding Sites; D005260:Female; D018628:Gene Dosage; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006657:Histones / Q000235:genetics*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000453:epidemiology / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000235:genetics; D016399:Lymphoma, T-Cell / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D056910:Republic of Korea / Q000453:epidemiology; D012306:Risk; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000378:metabolism; D055815:Young Adult
chemical_list: C468783:H2AX protein, human; D006657:Histones; D014157:Transcription Factors