title: Plasticity of somatosensory inputs to the cochlear nucleus--implications for tinnitus.
abstract: This chapter reviews evidence for functional connections of the somatosensory and auditory systems at the very lowest levels of the nervous system. Neural inputs from the dosal root and trigeminal ganglia, as well as their brain stem nuclei, cuneate, gracillis and trigeminal, terminate in the cochlear nuclei. Terminations are primarily in the shell regions surrounding the cochlear nuclei but some terminals are found in the magnocellular regions of cochlear nucleus. The effects of stimulating these inputs on multisensory integration are shown as short and long-term, both suppressive and enhancing. Evidence that these projections are glutamatergic and are altered after cochlear damage is provided in the light of probable influences on the modulation and generation of tinnitus.
authors.affiliation: Department of Otolaryngology, University of Michigan, 1150 W. Medical Center, Ann Arbor, MI 48109, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Shore
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001306:Auditory Pathways / Q000378:metabolism / Q000503:physiopathology*; D017626:Cochlear Nucleus / Q000378:metabolism / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D009473:Neuronal Plasticity; D013003:Somatosensory Cortex / Q000378:metabolism / Q000503:physiopathology*; D013997:Time Factors; D014012:Tinnitus / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D018698:Glutamic Acid