title: Helicobacter pylori genotypes and types of gastritis in first-degree relatives of gastric cancer patients.
abstract: The frequency of Helicobacter pylori vacA alleles, cagA, and jhp0947 and their association with types and advanced forms of gastritis in 143 first-degree relatives of gastric cancer (GC) patients was assessed. The subjects included 64/143 with antral-predominant gastritis, 68/143 with pangastritis, and 11/143 with corpus-predominant gastritis, with or without atrophy or intestinal metaplasia (IM). Further classification included the severity of atrophy or IM. Group I (40/143) included the subjects with moderate-marked atrophy or IM, group II (58/143) those with no atrophy or IM, and group III (45/143) with mild atrophy or IM. The frequency of vacA s1 was 79.7%, vacA s2 20.3%, m1 49.7%, m2 50.3%, cagA 76.2%, and jhp0947 58%. The most prevalent combination was vacAs1 cagA (+) (65.7%) (P=0.001). Of the 143 subjects, 85 (59.4%) showed atrophy or IM, and 40/85 (47%) developed the moderate-marked atrophy or IM. No significant correlation was found between genotypes and the types of gastritis, non-atrophy, atrophy, or IM and severe forms of atrophy or IM (P>0.05). It is proposed that H. pylori genotype status might not be considered as an important determinant of the types and advanced forms of gastritis in the first-degree relatives of GC patients.
authors.affiliation: Dept. of Microbiology, Faculty of Sciences, University of Tehran, Enghelab Ave., Tehran 141556455, Iran. farideh.siavoshi@yahoo.com
authors.forename: F
authors.initials: F
authors.lastname: Siavoshi
authors.forename: A
authors.initials: A
authors.lastname: Asgharzadeh
authors.forename: H
authors.initials: H
authors.lastname: Ghadiri
authors.forename: S
authors.initials: S
authors.lastname: Massarrat
authors.forename: S
authors.initials: S
authors.lastname: Latifi-Navid
authors.forename: M
authors.initials: M
authors.lastname: Zamani
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000942:Antigens, Bacterial / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001706:Biopsy; D004724:Endoscopy; D005260:Female; D005756:Gastritis / Q000382:microbiology*; D005787:Gene Frequency; D005838:Genotype; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D008679:Metaplasia / Q000473:pathology; D008875:Middle Aged; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D013274:Stomach Neoplasms / Q000382:microbiology*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D012336:RNA, Ribosomal, 16S; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori; C558121:CtkA protein, Helicobacter pylori; D017346:Protein Serine-Threonine Kinases