title: Identification of SACE_7040, a member of TetR family related to the morphological differentiation of Saccharopolyspora erythraea.
abstract: SACE_7040 is presumed to be a member of the TetR family of transcriptional regulators in Saccharopolyspora erythraea, but its biological function is unknown. It was shown that the SACE_7040 gene knockout mutant formed aerial mycelium earlier than its original strain, and this phenotype could be restored by complementation of a single copy of SACE_7040 gene, demonstrating that SACE_7040 is an important regulator of the morphological differentiation of Sac. erythraea. When SACE_7040 gene was disrupted in the bldD mutant, we intriguingly found that the defect in aerial development exhibited by the bldD mutant could be overcome, suggesting a crosstalk between SACE_7040 and BldD in Sac. erythraea morphogenesis. These findings provide novel insights toward the Sac. erythraea developmental biology.
authors.affiliation: School of Life Sciences, Anhui University, Jiu Long Road No. 111, Hefei, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Han
authors.forename: Ping
authors.initials: P
authors.lastname: Song
authors.forename: Ting
authors.initials: T
authors.lastname: Ren
authors.forename: Xunduan
authors.initials: X
authors.lastname: Huang
authors.forename: Cheng
authors.initials: C
authors.lastname: Cao
authors.forename: Buchang
authors.initials: B
authors.lastname: Zhang
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D055786:Gene Knockout Techniques; D005816:Genetic Complementation Test; D016930:Saccharopolyspora / Q000166:cytology* / Q000235:genetics / Q000254:growth & development*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D014157:Transcription Factors