title: Melanoma cell-secreted soluble factor that stimulates ubiquitination and degradation of the interferon alpha receptor and attenuates its signaling.
authors.forename: Wei-Chun
authors.initials: WC
authors.lastname: HuangFu
authors.forename: Juan
authors.initials: J
authors.lastname: Qian
authors.forename: Chengbao
authors.initials: C
authors.lastname: Liu
authors.forename: Hallgeir
authors.initials: H
authors.lastname: Rui
authors.forename: Serge Y
authors.initials: SY
authors.lastname: Fuchs
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017077:Culture Media, Conditioned / Q000737:chemistry; D015536:Down-Regulation; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D008545:Melanoma / Q000188:drug therapy / Q000378:metabolism; D009363:Neoplasm Proteins / Q000494:pharmacology*; D053633:Receptor, Interferon alpha-beta / Q000187:drug effects / Q000378:metabolism*; D050794:STAT1 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000188:drug therapy / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D000970:Antineoplastic Agents; D017077:Culture Media, Conditioned; C507964:IFNAR1 protein, human; D016898:Interferon-alpha; D009363:Neoplasm Proteins; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D053633:Receptor, Interferon alpha-beta