title: Leukocyte transfusion and the development of the continuous-flow blood cell separator.
abstract: The treatment of anemia and thrombocytopenia with allogeneic cell transfusions is an effective and well-developed technology. However, leukocyte replacement transfusion has been frustrated by the physiology of the leukocytes. To achieve effective leukocyte replacement, the continuous-flow centrifugal blood cell separator was developed, and it soon proved to be an important instrument for separation, collection, and transfusion of all the components of the blood. Thus, the continuous-flow centrifugal blood cell separator has become an important instrument in the science of blood collection and transfusion.
authors.affiliation: The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 55, Houston, TX 77030, USA. efreirei@mdanderson.org
authors.forename: Emil J
authors.initials: EJ
authors.lastname: Freireich
mesh_terms: D019264:Adoptive Transfer / Q000379:methods; D002469:Cell Separation / Q000266:history / Q000295:instrumentation*; D048429:Cell Size; D002498:Centrifugation / Q000266:history / Q000295:instrumentation; D004867:Equipment Design; D005043:Etiocholanolone / Q000627:therapeutic use; D006098:Granulocytes / Q000637:transplantation / Q000648:ultrastructure; D019650:Hematopoietic Stem Cell Mobilization; D049673:History, 20th Century; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use; D016867:Immunocompromised Host; D007239:Infections / Q000628:therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000276:immunology; D017708:Leukocyte Transfusion / Q000266:history* / Q000295:instrumentation / Q000379:methods; D008214:Lymphocytes / Q000648:ultrastructure; D008396:Maryland; D010952:Plasma Substitutes / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000276:immunology; D012212:Rheology; D013781:Texas
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D005043:Etiocholanolone