title: The methylation effect in medicinal chemistry.
authors.affiliation: Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, CCS, Cidade Universitária, CP 68.006, 21941-902 Rio de Janeiro, RJ, Brazil. ejbarreiro@ccsdecania.ufrj.br
authors.forename: Eliezer J
authors.initials: EJ
authors.lastname: Barreiro
authors.forename: Arthur E
authors.initials: AE
authors.lastname: Kümmerle
authors.forename: Carlos A M
authors.initials: CA
authors.lastname: Fraga
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D057927:Hydrophobic and Hydrophilic Interactions; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry; D008745:Methylation; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D004364:Pharmaceutical Preparations