title: Endemic tegumentary leishmaniasis in Brazil: correlation between level of endemicity and number of cases of mucosal disease.
abstract: The purpose of this study was to establish a correlation between the endemic level of tegumentary leishmaniasis in different regions of Brazil during 2002-2009 and the number of cases of mucosal or mucocutaneous leishmaniasis. The proportion of mucosal leishmaniasis was inversely correlated with prevalence of infection. In areas with a lower infection prevalence, the proportion of mucosal leishmaniasis increased (P < 0.05). The hypothesis of an Amazonian origin and dissemination through human migration is considered. Our results show that in regions with lower prevalence and endemically younger, the proportion of cases that evolve to the mucosal form is higher than in regions with higher prevalence and endemically older.
authors.affiliation: Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil. sandro.bedoya@ipec.fiocruz.br
authors.forename: Sandro J
authors.initials: SJ
authors.lastname: Bedoya-Pacheco
authors.forename: Maria H
authors.initials: MH
authors.lastname: Araujo-Melo
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Valete-Rosalino
authors.forename: Maria Inês F
authors.initials: MI
authors.lastname: Pimentel
authors.forename: Fátima
authors.initials: F
authors.lastname: Conceição-Silva
authors.forename: Armando O
authors.initials: AO
authors.lastname: Schubach
authors.forename: Mauro C A
authors.initials: MC
authors.lastname: Marzochi
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002947:Cities; D019353:Endemic Diseases / Q000706:statistics & numerical data*; D006801:Humans; D007897:Leishmaniasis, Mucocutaneous / Q000453:epidemiology* / Q000635:transmission*; D015995:Prevalence; D012044:Regression Analysis; D055815:Young Adult