title: [Progress in down-stream processing of biologically produced 1,3-propanediol].
abstract: 1,3-propanediol is an important raw material in chemical industry. Microbial conversion of glycerol or glucose into 1,3-propanediol has been given much attention due to its renewable resource, mild reaction conditions, and other advantages. It is a challenge to efficiently separate 1,3-propanediol from a mixture of multiple components, such as 1,3-propanediol, 2,3-butanediol, water, residual glycerol, ethanol, macromolecules and salts, for the reason that 1,3-propanediol, glycerol and 2,3-butanediol are all very hydrophilic and have intense polarity. The conventional evaporation and distillation techniques used in the purification of 1,3-propanediol suffer from the problem of high energy consumption and low recovery. It makes the recovery of 1,3-propanediol from a fermentation broth become a bottleneck in industrial production. The down-stream processing of biologically produced 1,3-propanediol mainly includes the removal of protein, salts, water and other impurities. This paper analyze the research progress of these separation technologies and point out the developing direction worth further investigation.
authors.affiliation: Institute of Applied Chemistry, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
authors.forename: Ruchun
authors.initials: R
authors.lastname: Wu
authors.forename: Yunzhen
authors.initials: Y
authors.lastname: Xu
authors.forename: Dehua
authors.initials: D
authors.lastname: Liu
mesh_terms: D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism*; D007218:Industrial Microbiology / Q000379:methods*; D011409:Propylene Glycols / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D011409:Propylene Glycols; C041787:1,3-propanediol; D005947:Glucose; D005990:Glycerol