title: [Relationship between MnSOD polymorphisms and susceptibility of chronic poisoning exposed to manganism occupationally].
abstract: OBJECTIVE
  To study the relationship between polymorphisms of MnSOD and the susceptibility of chronic poisoning exposed to manganism occupationally.
  
  
  METHODS
  In a study of case-control, genotypes were determined by PCR-RFLP in 164 patients with chronic occupational mangamism poisoning and 328 controls with age- and sex-matched for MnSOD 9Ala-Val.
  
  
  RESULTS
  There was a significant difference in the frequency of MnSOD 9Ala-Val at V locus mutant allele between cases and controls (χ(2) = 15.225, P < 0.01, 95%CI = 1.43 ∼ 3.00). Individuals with the genotype VV had a 1.30 of risk increase of occupational chronic manganism poisoning compared with the the genotype AV or AA (OR = 2.30, 95%CI = 1.52 ∼ 3.49, P < 0.05).
  
  
  CONCLUSIONS
  The MnSOD polymorphisms may be related with the susceptibility to chronic occupational manganism poisoning, the risk of chronic occupational manganism poisoning increases in carriers with genotype VV at MnSOD 9Ala-Val locus.
authors.affiliation: Shandong Academy of Occupational Health and Occupational Medicine, Jinan 250062, China.
authors.forename: Shao-lei
authors.initials: SL
authors.lastname: Cai
authors.forename: Ming-xia
authors.initials: MX
authors.lastname: Sun
authors.forename: Yong-jian
authors.initials: YJ
authors.lastname: Yan
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Sun
authors.forename: Bin
authors.initials: B
authors.lastname: Lin
authors.forename: Ji-hua
authors.initials: JH
authors.lastname: Fu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020149:Manganese Poisoning / Q000235:genetics*; D008875:Middle Aged; D009784:Occupational Diseases / Q000235:genetics*; D016273:Occupational Exposure; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: D013482:Superoxide Dismutase