title: [Hemorrhagic colitis caused by dasatinib following cytomegalovirus enterocolitis in a patient with chronic myelogenous leukemia in the second chronic phase].
abstract: A 26-year-old female progressed to blastic crisis (BC) after three months administration of imatinib for chronic myelogenous leukemia (CML) chronic phase (CP) and was treated with a dasatinib containing chemotherapy regimen. After remission to second CP, she was hospitalized because of fever and hemorrhagic diarrhea during dasatinib maintenance therapy. She was diagnosed as having cytomegalovirus (CMV) colitis because CMV antigen in blood leukocytes was positive and CMV-positive cells were also detected on staining of an ileocecal mucosal biopsy specimen with an anti-CMV antibody. Although blood leukocyte CMV antigen and CMV staining in colonic mucosa became negative after ganciclovir treatment, hemorrhagic diarrhea did not improve. However, after discontinuance of dasatinib, hemorrhagic colitis drastically improved and did not recur after administration of nilotinib. It is possible that hemorrhagic diarrhea occurred due to dasatinib-related hemorrhagic colitis. Previous case reports have indicated that CD8-positive T-lymphocytes infiltrate the colonic mucosa in dasatinib-related hemorrhagic colitis, and the same pathological findings were seen in our case. Dasatinib may cause hemorrhagic colitis via immunological mechanisms in CML. Dasatinib-related gastrointestinal bleeding is less frequent in Japan compared to that in western countries, and Japanese cases diagnosed as having hemorrhagic colitis are extremely rare.
authors.affiliation: Department of Hematology, Juntendo University School of Medicine, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Sunami
authors.forename: Eriko
authors.initials: E
authors.lastname: Sato
authors.forename: Kunimoto
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Yasuda
authors.forename: Norio
authors.initials: N
authors.lastname: Komatsu
mesh_terms: D000328:Adult; D003092:Colitis / Q000209:etiology*; D003586:Cytomegalovirus Infections; D000069439:Dasatinib; D004760:Enterocolitis / Q000209:etiology* / Q000821:virology*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D015466:Leukemia, Myeloid, Chronic-Phase / Q000150:complications* / Q000188:drug therapy*; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D011743:Pyrimidines; D013844:Thiazoles; D000069439:Dasatinib