title: [Multifoetal pregnancies complicated by reversed arterial perfusion: report of four cases].
abstract: BACKGROUND
  Twin reversed arterial perfusion syndrome (TRAP) or acardiac anomaly presents a rare and severe complication affecting monochorionic multiple pregnancies occurring in 1 per 35,000 pregnancies or 1 per 100 of monozygotic twins. We report four cases of multiple pregnancies with TRAP diagnosed over the last 2 years, which were under check-up and treatment during the entire pregnancy course finalized by delivery.
  
  
  METHODS
  In two cases pregnancies were trigeminal, and other two geminal, with acardia of one foetus, by anceps type in three and acephalus in one. Expectant management was initially done in all cases. The relation of acardiac and donor abdominal circumference was below 50% and negative signs of the donor's cardiac failure were detected in two cases, so that expectative management was continued until delivery. Due to obstetric indications, a cesarean section was performed on the 33rd and 34th gestational week, and healthy newborns were delivered. Another two acardiac twins had abdominal circumference ratio between the acardiac fetus and the donor of over 50%, and signs of congestive heart failure in the donor, which indicated invasive therapeutic procedure with absolute alcohol chemisclerosis; it was done by alcohol injection into the acardiac abdominal aorta which interrupted the retrograde blood-flow into the acardiac umbilicus. In the first case a successful intervention was performed at 29th gestational week, but after 12 hours distress signs were registered. The delivery was finalized by a cesarean section, and a live donor was delivered. In the second case the intervention was successfully done at the 20th gestational week, and after 96 hours from the intervention lethal ending of the donor was registered.
  
  
  CONCLUSIONS
  Bearing in mind that the occurrence of TRAP is rare, it is necessary to sum-up experiences from a larger number of centres to determine efficient therapeutic procedure.
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Miković
authors.forename: Natasa
authors.initials: N
authors.lastname: Karadzov-Orlić
authors.forename: Maja
authors.initials: M
authors.lastname: Marinković
authors.forename: Slavisa
authors.initials: S
authors.lastname: Djuricić
authors.forename: Amira
authors.initials: A
authors.lastname: Egić
authors.forename: Vladimir
authors.initials: V
authors.lastname: Pazin
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology*; D000328:Adult; D000757:Anencephaly / Q000473:pathology; D005260:Female; D005330:Fetofetal Transfusion; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011272:Pregnancy, Multiple; D014427:Twins