title: Bioactive neolignans and lignans from the bark of Machilus robusta.
abstract: Sixteen new neolignans and lignans (1-16), together with 12 known analogues, have been isolated from an ethanol extract of the bark of Machilus robusta. Compounds 1 and 2 showed activity against HIV-1 replication in vitro, with IC(50) values of 2.52 and 2.01 μM, respectively. At 10 μM, 6, 8, and 9 reduced dl-galactosamine-induced hepatocyte (WB-F344 cells) damage, and 9 could additionally attenuate rotenone-induced PC12 cell damage. The known compounds (-)-pinoresinol (17) and (+)-lyoniresinol (18) were active against serum deprivation induced PC12 cell damage.
authors.affiliation: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Yanru
authors.initials: Y
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Cheng
authors.forename: Chenggen
authors.initials: C
authors.lastname: Zhu
authors.forename: Chunsuo
authors.initials: C
authors.lastname: Yao
authors.forename: Liang
authors.initials: L
authors.lastname: Xiong
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Sujuan
authors.initials: S
authors.lastname: Wang
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Hu
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Yuhe
authors.initials: Y
authors.lastname: Yuan
authors.forename: Naihong
authors.initials: N
authors.lastname: Chen
authors.forename: Jiangong
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005688:Galactosamine / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D022781:Hepatocytes / Q000187:drug effects; D019770:Lauraceae / Q000737:chemistry*; D017705:Lignans / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells / Q000378:metabolism; D024301:Plant Bark / Q000737:chemistry; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal; D017705:Lignans; D005688:Galactosamine