title: Cushing syndrome due to ectopic adrenocorticotropic hormone secretion in a 3-year-old child.
abstract: Ectopic adrenocorticotrophic hormone (ACTH) secretion is a rare cause of Cushing syndrome in paediatric age, due to tumours arising from different tissues. To date, only 11 reports of ACTH-secreting pancreatic tumours in children and adolescents exist in the literature. We present a paediatric case of Cushing syndrome caused by ectopic ACTH secretion. This was caused by a large acinar cell carcinoma that developed in the pancreas of a 3-year-old girl.
authors.affiliation: Department of Paediatric Endocrinology and Diabetology, University of Torino, Regina Margherita Children Hospital, Torino, Italy. patrizia.matarazzo@oirmsantanna.piemonte.it
authors.forename: Patrizia
authors.initials: P
authors.lastname: Matarazzo
authors.forename: Gerdi
authors.initials: G
authors.lastname: Tuli
authors.forename: Daniele
authors.initials: D
authors.lastname: Tessaris
authors.forename: Francesca
authors.initials: F
authors.lastname: Verna
authors.forename: Ivana
authors.initials: I
authors.lastname: Rabbone
authors.forename: Antonella
authors.initials: A
authors.lastname: Lezo
authors.forename: Andrea
authors.initials: A
authors.lastname: Brunati
authors.forename: Mauro
authors.initials: M
authors.lastname: Salizzoni
authors.forename: Giulia
authors.initials: G
authors.lastname: Carbonaro
authors.forename: Massimo
authors.initials: M
authors.lastname: Terzolo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Reimondo
authors.forename: Mauro
authors.initials: M
authors.lastname: Papotti
authors.forename: Roberto
authors.initials: R
authors.lastname: Lala
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D018267:Carcinoma, Acinar Cell / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003480:Cushing Syndrome / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D013505:Digestive System Surgical Procedures; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000324:Adrenocorticotropic Hormone; D007654:Ketoconazole