title: Outcomes of antiretroviral therapy in the Swiss HIV Cohort Study: latent class analysis.
abstract: An in-depth understanding of the different groups that make up the HIV-infected population should inform prevention and care. Using latent class analysis (LCA) we identified seven groups with similar socio-demographic and behavioral characteristics at enrolment in the Swiss HIV Cohort Study: older gay men, younger gay men, older heterosexual men, injection drug users, single migrants, migrant women in partnerships and heterosexual men and women. Outcomes of combination antiretroviral therapy (ART) were analyzed in 1,633 patients starting ART. Compared to older gay men, the probability of a virologic response to ART was reduced in single migrants, in older heterosexual men and in IDUs. Loss to follow-up was higher in single migrants and IDUs, and mortality was increased in older heterosexual men and IDUs. Socio-behavioral groups identified by LCA allow insights above what can be gleaned from traditional transmission groups, and may identify patients who could benefit from targeted interventions.
authors.affiliation: Institute of Social and Preventive Medicine, University of Bern, Switzerland. okeiser@ipsm.unibe.ch
authors.forename: Olivia
authors.initials: O
authors.lastname: Keiser
authors.forename: Ben
authors.initials: B
authors.lastname: Spycher
authors.forename: Andri
authors.initials: A
authors.lastname: Rauch
authors.forename: Alexandra
authors.initials: A
authors.lastname: Calmy
authors.forename: Matthias
authors.initials: M
authors.lastname: Cavassini
authors.forename: Tracy R
authors.initials: TR
authors.lastname: Glass
authors.forename: Dunja
authors.initials: D
authors.lastname: Nicca
authors.forename: Bruno
authors.initials: B
authors.lastname: Ledergerber
authors.forename: Matthias
authors.initials: M
authors.lastname: Egger
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D016000:Cluster Analysis; D015331:Cohort Studies; D005260:Female; D006679:HIV Seropositivity / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission; D007722:Health Knowledge, Attitudes, Practice; D020010:Heterosexuality / Q000706:statistics & numerical data; D018451:Homosexuality, Male / Q000706:statistics & numerical data; D006801:Humans; D059012:Lost to Follow-Up; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D013557:Switzerland / Q000453:epidemiology; D014171:Transients and Migrants / Q000706:statistics & numerical data; D016896:Treatment Outcome; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents