title: [Key laboratory diagnostic biomarkers of coronary atherosclerosis].
abstract: Laboratory lipid and lipoprotein biomarkers (total cholesterol - CH, triglycerides - TG, low-density and high-density lipoprotein cholesterol- LDL-CH, HDL-CH, apolipoproteins B and A1 - apoB, apoA1), carbohydrate biomarkers (plasma glucose, basal insulin), high sensitive C-reactive protein (hsCRP) and oxidative biomarkers (basal level of lipid peroxidation [LPO] products in LDL, LDL resistance to oxidation in vitro, oxidative modification of apoLDL and level of LDL lipophilic antioxidants) were studied in 388 men aged 42-70 years: 96 citizens of Western Siberia with angiographically documented coronary atherosclerosis and coronary heart disease (CHD); 292 men of population sample of citizens of Novosibirsk, including 44 men with CHD confirmed by standardized criteria and methods. Significant associations were found of coronary atherosclerosis and CHD with laboratory diagnostic biomarkers like blood levels of HDL-CH, TG, apoB, apoA1, basal insulin, hsCRP and basal level of LPO products in LDL and LDL resistance to oxidation.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Ragino
authors.forename: A M
authors.initials: AM
authors.lastname: Cherniavskiĭ
authors.forename: N V
authors.initials: NV
authors.lastname: Eremenko
authors.forename: E V
authors.initials: EV
authors.lastname: Shakhtshneĭder
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Polonskaia
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Tsymbal
authors.forename: M V
authors.initials: MV
authors.lastname: Ivanova
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D001055:Apolipoproteins B / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D002097:C-Reactive Protein / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000378:metabolism; D003627:Data Interpretation, Statistical; D006801:Humans; D007328:Insulin / Q000097:blood*; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012800:Siberia / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood*
chemical_list: D000975:Antioxidants; D001055:Apolipoproteins B; D015415:Biomarkers; D001786:Blood Glucose; D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol