title: Micropatterned fiber scaffolds for spatially controlled cell adhesion.
abstract: Because the local microstructure plays a pivotal role for many biological functions, a wide range of methods have been developed to design precisely engineered substrates for both fundamental biological studies and biotechnological applications. However, these techniques have been by-and-large limited to flat surfaces. Herein, we use electrohydrodynamic co-spinning to prepare biodegradable three-dimensional fiber scaffolds with precisely engineered, micrometre-scale patterns, wherein each fiber is comprised of two distinguishable compartments. When bicompartmental fiber scaffolds are modified via spatially controlled peptide immobilization, highly selective cell guidance at spatial resolutions (<10 µm), so far exclusively reserved for flat substrates, is achieved. Microstructured fiber scaffolds may have utility for a range of biotechnological applications including tissue engineering or cell-based assays.
authors.affiliation: Department of Chemical Engineering, University of Michigan, 48109 (USA).
authors.forename: Suparna
authors.initials: S
authors.lastname: Mandal
authors.forename: Srijanani
authors.initials: S
authors.lastname: Bhaskar
authors.forename: Joerg
authors.initials: J
authors.lastname: Lahann