title: Chronic granulomatous disease: a review of the infectious and inflammatory complications.
abstract: Chronic Granulomatous Disease is the most commonly encountered immunodeficiency involving the phagocyte, and is characterized by repeated infections with bacterial and fungal pathogens, as well as the formation of granulomas in tissue. The disease is the result of a disorder of the NADPH oxidase system, culminating in an inability of the phagocyte to generate superoxide, leading to the defective killing of pathogenic organisms. This can lead to infections with Staphylococcus aureus, Psedomonas species, Nocardia species, and fungi (such as Aspergillus species and Candida albicans). Involvement of vital or large organs can contribute to morbidity and/or mortality in the affected patients. Major advances have occurred in the diagnosis and treatment of this disease, with the potential for gene therapy or stem cell transplantation looming on the horizon.
authors.affiliation: Department of Pediatrics, Division of Allergy and Clinical Immunology, Quillen College of Medicine, East Tennessee State University, USA. krishnas@etsu.edu.
authors.forename: Eunkyung
authors.initials: E
authors.lastname: Song
authors.forename: Gayatri Bala
authors.initials: GB
authors.lastname: Jaishankar
authors.forename: Hana
authors.initials: H
authors.lastname: Saleh
authors.forename: Warit
authors.initials: W
authors.lastname: Jithpratuck
authors.forename: Ryan
authors.initials: R
authors.lastname: Sahni
authors.forename: Guha
authors.initials: G
authors.lastname: Krishnaswamy