title: EDTA redistribution of lead and cadmium into the soft tissues in a human with a high lead burden - should DMSA always be used to follow EDTA in such cases?
abstract: Intravenous sodium calcium ethylene diamine tetra acetic acid (EDTA) and oral 2,3-dimercaptosuccinic acid (DMSA) have both been used to reduce the burden of lead in humans. Each of these agents enhances the mobilization of lead from different areas of the body - EDTA from the trabecular bone and DMSA from the soft tissue. A study of Korean battery workers revealed that EDTA appeared to increase the soft tissue burden of lead, resulting in increased levels of aminolevulinic acid and greater subsequent lead mobilization with DMSA. This case report discusses a patient with a higher-than-normal lead burden who exhibited increased tissue lead burden after intravenous EDTA. The elevated tissue burden of lead was still present, albeit lower, after five consecutive days of oral DMSA therapy. If this single case is representative of a typical human response to the use of intravenous (IV) EDTA for lead, then it suggests that all persons undergoing such treatment should be administered oral DMSA for a minimum of one week after EDTA treatment.
authors.affiliation: Southwest College of Naturopathic Medicine, Tempe, AZ, USA. w.crinnion@scnm.edu
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Crinnion
mesh_terms: D002104:Cadmium / Q000493:pharmacokinetics*; D015913:Chelation Therapy / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000008:administration & dosage*; D006801:Humans; D007854:Lead / Q000493:pharmacokinetics*; D007855:Lead Poisoning / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D004113:Succimer / Q000008:administration & dosage*; D014018:Tissue Distribution / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D002104:Cadmium; D007854:Lead; D004492:Edetic Acid; D004113:Succimer