title: Correlation between E-cadherin and CD44 adhesion molecules expression and cervical lymph node metastasis in oral tongue SCC: Predictive significance or not.
abstract: The aim of this article was to evaluate the expression of E-cadherin and CD44 adhesion molecule in oral tongue squamous cell carcinoma (SCC) since inappropriate expression of adhesion molecules raises the metastatic ability of the tumor cells. Biopsy specimens from 92 patients with tongue SCC were examined for the expression of E-cadherin and CD44 by immunohistochemistry. The relationship of immunoreactivity with tumor stage and cervical lymph node metastasis was then analyzed. Sixty-one patients (66.3%) had reduced or negative staining for CD44. Weak or absent staining for E-cadherin was seen in 14 patients (15.21%). Cervical lymph node metastasis is associated with decreased or negative staining for CD44, but no association was found between E-cadherin immunoreactivity and nodal metastasis. Our study reveals that reduced expression of CD44 could be an indicator of high invasiveness of tumor by increasing cervical lymph node metastasis.
authors.affiliation: Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Leila Vazifeh
authors.initials: LV
authors.lastname: Mostaan
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Khorsandi
authors.forename: Shahriar-Mohammad Reza
authors.initials: SM
authors.lastname: Sharifian
authors.forename: Fatemeh Homee
authors.initials: FH
authors.lastname: Shandiz
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mirashrafi
authors.forename: Homa
authors.initials: H
authors.lastname: Sabzari
authors.forename: Reza
authors.initials: R
authors.lastname: Badiee
authors.forename: Hasti
authors.initials: H
authors.lastname: Borghei
authors.forename: Nasrin
authors.initials: N
authors.lastname: Yazdani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D009333:Neck; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C497483:CD44 protein, human; D015820:Cadherins; D018960:Hyaluronan Receptors