title: Cerebral vascular hamartoma with thrombosis in a dog.
abstract: A cerebral vascular hamartoma was identified in the frontal lobe, striatum and thalamus of the right side of the brain of a male, 7-year-old Shih Tzu. Histologically, the lesion consisted of thin-walled vessels, which showed various sizes and occasionally contained fibrin thrombi. These vascular walls were composed of a single layer of fibromuscular tissue lined by flat endothelium with various amount of collagen, but devoid of large coat of smooth muscles and elastic tissue. Immunohistochemically, the lining endothelial cells were positive for von Willebrand Factor antibody. Neuropil between the vessels was stained with Klüver-Barrera stain, and positive for synaptophysin and GFAP antibodies. Based on these findings, the lesion was diagnosed as vascular hamartoma, which might resemble venous malformation in humans.
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Tottori, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Sakurai
authors.forename: Takehito
authors.initials: T
authors.lastname: Morita
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kondo
authors.forename: Takashi
authors.initials: T
authors.lastname: Uemura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Haruna
authors.forename: Akinori
authors.initials: A
authors.lastname: Shimada
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D003342:Corpus Striatum / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005625:Frontal Lobe / Q000473:pathology; D006222:Hamartoma / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009383:Neoplasms, Vascular Tissue / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D013788:Thalamus / Q000473:pathology; D013927:Thrombosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*