title: Light acts through melanopsin to alter retinal waves and segregation of retinogeniculate afferents.
abstract: Waves of correlated activity sweeping across the early postnatal mouse retina promote the segregation and refinement of retinofugal projections. This process has been thought to be spontaneous and unaffected by visual experience. We found, however, that light prolongs spiking during the waves and enhances the segregation of retinogeniculate afferents, and that it did so by activating melanopsin-expressing, intrinsically photosensitive retinal ganglion cells.
authors.affiliation: Department of Neuroscience, Brown University, Providence, Rhode Island, USA. jordan_renna@brown.edu
authors.forename: Jordan M
authors.initials: JM
authors.lastname: Renna
authors.forename: Shijun
authors.initials: S
authors.lastname: Weng
authors.forename: David M
authors.initials: DM
authors.lastname: Berson
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000344:Afferent Pathways / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D002772:Cholera Toxin / Q000378:metabolism; D004566:Electrodes; D007839:Functional Laterality; D005829:Geniculate Bodies / Q000502:physiology*; D049452:Green Fluorescent Proteins / Q000235:genetics; D066298:In Vitro Techniques; D008027:Light; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010775:Photic Stimulation / Q000379:methods; D012160:Retina / Q000166:cytology / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology; D017299:Rod Opsins / Q000235:genetics / Q000502:physiology*; D000099210:Melanopsin
chemical_list: D002772:Cholera Toxin; D049452:Green Fluorescent Proteins; D017299:Rod Opsins; D000099210:Melanopsin; C485184:enhanced green fluorescent protein