title: Fishing potential antitumor agents from natural plant extracts pool by dialysis and G-quadruplex recognition.
abstract: Screening G-quadruplex ligands from natural plants is important because the ligands may be potential antitumor drugs. A new screening strategy is proposed based on the combination of dialysis and G-quadruplex recognition technique which could separates G-quadruplex ligand from natural extracts and elucidate the structure of this ligand. This result offers a novel approach to obtain active antitumor compounds.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, State Key Laboratory for Structural Chemistry for Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Shang
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Xiang
authors.forename: Xiu-Feng
authors.initials: XF
authors.lastname: Zhang
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Sun
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Ya-Lin
authors.initials: YL
authors.lastname: Tang
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification*; D003956:Dialysis; D055808:Drug Discovery / Q000379:methods*; D054856:G-Quadruplexes; D008024:Ligands; D008722:Methods; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D010936:Plant Extracts