title: Polymorphisms of pon1 and pon2 genes in hemodialyzed patients.
abstract: OBJECTIVE
  Q192R, L55M and -108C>T polymorphisms of pon1 gene affect PON1 paraoxonase activity while S311C polymorphism of pon2 gene might be associated with coronary heart disease. The aims of this study were to determine the frequencies of Q192R, L55M, -108C>T and S311C polymorphisms in hemodialyzed patients and to examine the relationship between pon1 gene polymorphisms and PON1 paraoxonase activity in those patients.
  
  
  METHODS
  The study included 238 control subjects and 263 hemodialyzed patients.
  
  
  RESULTS
  PON1 paraoxonase activity was lower in patients. Genotype frequencies were different between two compared groups only for L55M polymorphism, with control group having higher frequency of MM genotype. Polymorphisms of pon1 gene were associated with significant variation in PON1 paraoxonase activity in both study groups.
  
  
  CONCLUSIONS
  Our results suggest that Q192R, L55M and -108C>T polymorphisms are not by itself the causal factors leading to the lower PON1 paraoxonase activity in hemodialyzed patients.
authors.affiliation: Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. m_grdic@yahoo.com
authors.forename: Marija Grdić
authors.initials: MG
authors.lastname: Rajković
authors.forename: Karmela
authors.initials: K
authors.lastname: Barišić
authors.forename: Dubravka
authors.initials: D
authors.lastname: Juretić
authors.forename: Tihana Žanić
authors.initials: TŽ
authors.lastname: Grubišić
authors.forename: Zlata
authors.initials: Z
authors.lastname: Flegar-Meštrić
authors.forename: Lada
authors.initials: L
authors.lastname: Rumora
mesh_terms: D043303:Aryldialkylphosphatase / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D017523:Croatia; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D006435:Renal Dialysis
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C468411:PON2 protein, human