title: Successful intravenous thrombolysis in a 14-year-old boy with ischemic stroke.
abstract: We report a healthy 14-year-old boy with an acute left middle cerebral artery stroke, treated 2 hours after the onset of symptoms with intravenous recombinant tissue plasminogen activator (r-TPA). Recanalization of the middle cerebral artery was documented with transcranial Doppler during the first 5 minutes of intravenous r-TPA perfusion, and progressive recovery of the neurological deficits occurred. Although lack of evidence regarding safety and efficacy in children precludes the recommendation of systematic use of r-TPA in pediatric stroke, we propose that this option should be considered and discussed with the parents, especially in older children presenting within 3 hours in centers with experience in adult thrombolysis.
authors.affiliation: Pediatrics Department, Hospital de Santa Maria, Lisbon, Portugal. i_sampaio@yahoo.com
authors.forename: Isabel
authors.initials: I
authors.lastname: Sampaio
authors.forename: Francisco
authors.initials: F
authors.lastname: Abecasis
authors.forename: Sofia
authors.initials: S
authors.lastname: Quintas
authors.forename: Teresa
authors.initials: T
authors.lastname: Moreno
authors.forename: Cristina
authors.initials: C
authors.lastname: Camilo
authors.forename: Marisa
authors.initials: M
authors.lastname: Vieira
authors.forename: Teresa
authors.initials: T
authors.lastname: Pinho e Melo
authors.forename: Manuela
authors.initials: M
authors.lastname: Correia
mesh_terms: D000293:Adolescent; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis / Q000188:drug therapy*; D007275:Injections, Intravenous; D008297:Male; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator