title: Role of nitric oxide and flavohemoglobin homolog genes in Aspergillus nidulans sexual development and mycotoxin production.
abstract: Flavohemoglobins are widely distributed in both prokaryotes and eukaryotes. These proteins are involved in reducing nitric oxide levels. Deletion of the Aspergillus nidulans flavohemoglobin gene fhbA induced sexual development and decreased sterigmatocystin production. Supplementation with a nitric oxide-releasing compound promoted cleistothecial formation and increased nsdD and steA expression, indicating that nitric oxide induces sexual development. This is the first study on the effect of nitric oxide on morphogenesis and secondary metabolism in fungi.
authors.affiliation: Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA.
authors.forename: Sachin
authors.initials: S
authors.lastname: Baidya
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Cary
authors.forename: W Scott
authors.initials: WS
authors.lastname: Grayburn
authors.forename: A M
authors.initials: AM
authors.lastname: Calvo
mesh_terms: D001233:Aspergillus nidulans / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D006420:Hemeproteins / Q000096:biosynthesis* / Q000235:genetics; D009024:Morphogenesis / Q000235:genetics; D009183:Mycotoxins / Q000096:biosynthesis* / Q000235:genetics; D009569:Nitric Oxide / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D015398:Signal Transduction; D013241:Sterigmatocystin / Q000096:biosynthesis
chemical_list: D005656:Fungal Proteins; D006420:Hemeproteins; D009183:Mycotoxins; D012333:RNA, Messenger; D013241:Sterigmatocystin; D009569:Nitric Oxide