title: Effects of intrathecal baclofen on daily care in children with secondary generalized dystonia: a pilot study.
abstract: OBJECTIVE
  Treatment options for dystonic cerebral palsy (CP) are limited. Our aims were to determine whether intrathecal baclofen (ITB) improves daily care, decreases dystonia and decreases pain in patients with dystonic CP.
  
  
  METHODS
  Patients received randomized blinded treatment with ITB or placebo. Scores on problems of daily care were recorded and dystonia, pain and comfort were assessed.
  
  
  RESULTS
  Four patients (three males, average age 12 years 6 months) were included (all Gross Motor Function Classification System level V). During the trial period problem scores and dystonia scores decreased in all four patients.
  
  
  CONCLUSIONS
  In this pilot study we report positive functional effects of ITB trial treatment in four patients with dystonic CP. A randomized trial with a larger cohort is needed to verify these results.
authors.affiliation: Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Bonouvrié
authors.forename: Petra E M
authors.initials: PE
authors.lastname: van Schie
authors.forename: Jules G
authors.initials: JG
authors.lastname: Becher
authors.forename: Willem J R
authors.initials: WJ
authors.lastname: van Ouwerkerk
authors.forename: Alexander
authors.initials: A
authors.lastname: Reeuwijk
authors.forename: R
authors.initials: R
authors.lastname: Jeroen Vermeulen
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D001418:Baclofen / Q000008:administration & dosage*; D002648:Child; D004311:Double-Blind Method; D020821:Dystonic Disorders / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D010865:Pilot Projects; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen