title: A metastatic case of gastrointestinal stromal tumor (GIST) treated with imatinib mesylate (Glivec(®)) in Mali.
abstract: Gastrointestinal stromal tumors (GIST) usually showing a spindle cells pattern of cell proliferation have recently benefit from a molecular definition. Indeed imatinib mesylate (Gleevec(®)) treatment has dramatically improved the management of these tumors as they frequently express the c-kit oncogene. We report the first case of a metastatic gastric GIST in a man of 45 years diagnosed and treated in Mali. The gastric tumor was particularly aggressive with a large intra-abdominal and mesenteric spreading and liver metastases. The diagnosis was done on the CD117 and CD34 expression in the tumor sample obtained by laparotomy. After a 34 months 400mg/day imatinib mesylate (Gleevec(®)) treatment a dramatic tumor regression was obtained.
authors.affiliation: Service d'Hématologie Oncologie Médicale, CHU du point G, BP 333 Bamako, Mali. dadiallo@icermali.org
authors.forename: D A
authors.initials: DA
authors.lastname: Diallo
authors.forename: M
authors.initials: M
authors.lastname: Ly
authors.forename: G
authors.initials: G
authors.lastname: Diallo
authors.forename: A K
authors.initials: AK
authors.lastname: Dembélé
authors.forename: M
authors.initials: M
authors.lastname: Touré
authors.forename: B A
authors.initials: BA
authors.lastname: Touré
authors.forename: A
authors.initials: A
authors.lastname: Koné
authors.forename: S
authors.initials: S
authors.lastname: Sidibé
authors.forename: M
authors.initials: M
authors.lastname: Dembelé
authors.forename: B C
authors.initials: BC
authors.lastname: Traore
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000556:secondary*; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate