title: Time-dependent changes in the plasma amino acid concentration in diabetes mellitus.
abstract: We investigated longitudinal change in the amino acid (AA) profile in type 1 diabetes mellitus (DM) using AKITA mice, which develop DM as a result of insulin deficiency. The plasma concentrations of valine, leucine, isoleucine, as well as the total branched chain amino acids, alanine, citrulline and proline, were significantly higher in the diabetic mice. We show that the degree and timing of the changes were different among the plasma amino acid concentrations (pAAs) during the development of type 1 DM.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Kumamoto 860-8556, Japan.
authors.forename: Taiga
authors.initials: T
authors.lastname: Mochida
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Shiraki
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tajiri
authors.forename: Shirou
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Shimbo
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ando
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okamoto
authors.forename: Fumio
authors.initials: F
authors.lastname: Endo
mesh_terms: D000409:Alanine / Q000097:blood; D000596:Amino Acids / Q000097:blood*; D000597:Amino Acids, Branched-Chain / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D007532:Isoleucine / Q000378:metabolism; D007930:Leucine / Q000097:blood; D008137:Longitudinal Studies; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D001786:Blood Glucose; D007328:Insulin; D007532:Isoleucine; D007930:Leucine; D000409:Alanine