title: Chlorination and ortho-acetoxylation of 2-arylbenzoxazoles.
abstract: Efficient and facile catalytic protocols for chlorination and ligand-directed ortho-acetoxylation of 2-arylbenzoxazoles have been developed. The chlorination is not a ligand-directed ortho-functionalization, but an electrophilic substitution process in the benzo ring of the benzoxazole moiety. Meanwhile, the acetoxylation exhibited high regioselectivity for the substrates containing a meta-substituent and occurred at the less sterically hindered ortho-C-H bond of the directing group.
authors.affiliation: Chemistry Department, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou 450052, People's Republic of China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Leng
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Weiguo
authors.initials: W
authors.lastname: Zhu
authors.forename: Yangjie
authors.initials: Y
authors.lastname: Wu
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
mesh_terms: D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D054879:Halogenation; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D015394:Molecular Structure; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D001583:Benzoxazoles; D008024:Ligands