title: Management of congenital uterine abnormalities.
abstract: Congenital uterine abnormalities are a heterogeneous group of uterine configurations that may adversely affect reproductive potential. Although subtle variations can occur, the more common abnormalities fall into two broad categories of unilateral development or failure of midline fusion. These abnormalities have been well described for over a century although the mechanisms of their unfavourable impact on fertility and clinical management have not been systematically studied until recently. The quality of the literature on this topic has traditionally fallen below the level on which solid evidence-based decisions can be made. Nonetheless, considerable progress has been made in recent times. The understanding of the aetiology of these abnormalities and how they impact reproduction has matured and evolved and this evolution and the growing body of recent studies better define clinical scenarios in which intervention will clearly and positively impact outcome. This article will review four common congenital abnormalities, their impact on reproduction, options for management and the role of assisted reproduction treatment in maximizing reproductive potential. Recommendations are made with consideration of the quality of the literature in an outcome-driven environment.
authors.affiliation: Seattle Reproductive Medicine, 1505 Westlake Avenue N, Suite 400, Seattle WA 98109, USA. gerard.letterie@integramed.com
authors.forename: Gerard S
authors.initials: GS
authors.lastname: Letterie
mesh_terms: D001723:Birth Rate; D005260:Female; D006801:Humans; D007047:Hysterosalpingography; D007247:Infertility, Female / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D014591:Uterine Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000601:surgery*; D014599:Uterus / Q000002:abnormalities / Q000601:surgery*