title: Therapy related myelodysplastic syndrome: a case report and review of literature.
abstract: Therapy related myeloid neoplasm is directly related to previous cytotoxic chemotherapy or radiation therapy. We present a 47-year-old lady who developed therapy related myelodysplastic syndrome (MDS) 2.5 years after she received four cycles of chemotherapy and local radiation therapy for carcinoma breast. She presented with bicytopenia with trilineage dyspoiesis in the peripheral blood, bone marrow aspirate and biopsy. Fluorescent in-situ hybridization studies did not reveal any of the common abnormalities associated with MDS. A diagnosis of therapy related MDS was rendered. Different studies have shown that patients treated with alkylating agents and ionizing radiation present as MDS with a latent period of 3-10 years. Our patient developed MDS within 2.5 years of starting chemotherapy and radiotherapy and did not reveal any of the conventional cytogenetic abnormalities. It highlights the importance of simple tests like a complete blood count and peripheral blood smear examination in follow-up of the patients treated with chemotherapy.
authors.affiliation: Department of Pathology, LTMG Hospital, Sion, Mumbai, India.
authors.forename: Smita
authors.initials: S
authors.lastname: Sonawane
authors.forename: Nitin
authors.initials: N
authors.lastname: Gadgil
authors.forename: Sangita
authors.initials: S
authors.lastname: Margam
mesh_terms: D001943:Breast Neoplasms / Q000150:complications / Q000628:therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced* / Q000473:pathology*; D011878:Radiotherapy / Q000009:adverse effects*