title: Lack of relationship between sedentary behaviour and vascular function in children.
abstract: Some evidence suggests that sedentary behaviour is independently associated with cardiovascular (CV) risk. Endothelial dysfunction is the earliest detectable manifestation of CVD and a strong independent predictor of CV events. No previous study has examined the relationship between sedentary behaviour and endothelial function. We assessed the basal association between conduit artery endothelial function and sedentary behaviour in children, along with the correlation between changes in sedentary behaviour and endothelial function. We studied 116 children (70♀: 10.7 ± 0.3; 46♂: 10.7 ± 0.3 years) on two occasions; in the summer (June) and late autumn (November). We assessed endothelial function via flow-mediated dilation (FMD) using high-resolution Doppler ultrasound. Sedentary behaviour (SB) was assessed using objective uni-axial accelerometry. At baseline, there were no significant differences between girls and boys for any measured variables with the exception of total physical activity time. FMD was not associated with sedentary behaviour in either group or in the cohort as a whole. Although FMD decreased (10.0 ± 4.3-7.9 ± 3.9%, P < 0.001) and SB increased (499.1 ± 103.5-559 ± 81.6 min/day, P < 0.001) between the seasons, no relationship existed between changes in these variables. Our data suggest that sedentary behaviour and changes in sedentary behaviour are not associated with endothelial function in children.
authors.affiliation: Research Institute for Sport and Exercise Science, Liverpool John Moore's University, Tom Reilly Building, Byrom St, Liverpool, L3 3AF, UK. N.D.Hopkins@LJMU.ac.uk
authors.forename: Nicola
authors.initials: N
authors.lastname: Hopkins
authors.forename: G
authors.initials: G
authors.lastname: Stratton
authors.forename: N D
authors.initials: ND
authors.lastname: Ridgers
authors.forename: L E F
authors.initials: LE
authors.lastname: Graves
authors.forename: N T
authors.initials: NT
authors.lastname: Cable
authors.forename: D J
authors.initials: DJ
authors.lastname: Green
mesh_terms: D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000502:physiology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D057185:Sedentary Behavior; D013223:Statistics as Topic; D014463:Ultrasonography; D014661:Vasoconstriction