title: [Modification of GSTM1, GSTT1 and GSTP1 gene polymorphisms on urinary 1-hydroxypyrene excretions].
abstract: OBJECTIVE
  To investigate the modification of GSTM1, GSTT1 and GSTP1 gene polymorphisms on urinary 1-hydroxypyrene (1-OHP) excretions in workers under different exposure levels.
  
  
  METHODS
  Four hundred and forty-seven occupationally exposed workers from two coking plants and 220 control workers from a wire rod plant were genotyped to analyze the modification of GSTM1, GSTT1 and GSTP1 gene polymorphisms on urinary 1-OHP excretions.
  
  
  RESULTS
  The urinary 1-OHP concentration in exposed group was much higher than that in control group (4.61 vs 0.34 µmol/mol Cr, P < 0.05). Occupational exposure levels and cigarette smoking were of the dominating factors affecting 1-OHP excretions in urine. After controlling potential confounders, decreased excretion of urinary 1-OHP was associated with GSTP1 I105V AG + GG genotype in coke oven workers (single-gene model, P = 0.012; multi-gene model, P = 0.011) and with GSTT1 null type in the analysis including all subjects (P = 0.055 in both single-gene and multi-gene models). GSTT1 and GSTP1 were interacted on the urinary concentrations of 1-OHP.
  
  
  CONCLUSIONS
  Urinary 1-OHP concentrations can be modified by GSTM1, GSTT1 and GSTP1 gene polymorphisms, indicating that these genes are involved in the metabolism of polycyclic aromatic hydrocarbons.
authors.affiliation: Department of Nutrition and Food Hygiene, Fudan University, Shanghai 200032, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Gao
authors.forename: Zhi-yin
authors.initials: ZY
authors.lastname: Xu
authors.forename: Shu-guang
authors.initials: SG
authors.lastname: Li
authors.forename: Tai-guang
authors.initials: TG
authors.lastname: Jin
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D035061:Control Groups; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D020641:Polymorphism, Single Nucleotide; D011721:Pyrenes / Q000032:analysis*; D016482:Urinalysis; D055815:Young Adult
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D011721:Pyrenes; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human; C033146:1-hydroxypyrene