title: Transient, three-dimensional flow field simulation through a mechanical, trileaflet heart valve prosthesis.
abstract: Thromboembolic complications are one of the major challenges faced by designers and researchers in development of artificial organs with blood-contacting devices such as heart valve prostheses, especially mechanical valves. Besides increasing the thrombogenic potential, these valves change the hydrodynamic performance of the heart. In this study, the flow through a trileaflet, mechanical heart valve prosthesis was modeled with transient computational fluid dynamics to analyze flow patterns causing thrombus formations on valves. The valve was simulated under conditions of a test rig (THIA II), which was specially designed to analyze different valves with respect to thrombosis. The main goal of this study was to mimic the exact conditions of the test rig to be able to compare numerical and experimental results. The boundary conditions were obtained from experimental data as leaflet kinematics and pressure profiles. One complete cycle of the valve was simulated. Numerical flow and pressure results were analyzed and compared with experimental results. Shear stress and shear rates were determined with respect to thrombogenic potential, especially in the pivot regions, which seem to be the main influence for activation and deposition of thrombocytes. Approximately 0.7% of the blood volume moving through the fluid domain of the valve was exposed to shear rates high enough to cause platelet activation. However, shear rates of up to 20,000 s⁻¹ occurred in pivot regions. The pressure differences between the simulation and experimental data were approximately 2.5% during systole and increased up to 25% during diastole. The presented method, however, can be used to gain more information about the flow through different heart valve prostheses and, thus, improve the development process.
authors.affiliation: Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany. kaufmann@hia.rwth-aachen.de
authors.forename: Tim A S
authors.initials: TA
authors.lastname: Kaufmann
authors.forename: Torsten
authors.initials: T
authors.lastname: Linde
authors.forename: Elena
authors.initials: E
authors.lastname: Cuenca-Navalon
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmitz
authors.forename: Marcus
authors.initials: M
authors.lastname: Hormes
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmitz-Rode
authors.forename: Ulrich
authors.initials: U
authors.lastname: Steinseifer
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D001792:Blood Platelets / Q000166:cytology; D003198:Computer Simulation; D006350:Heart Valve Prosthesis; D006351:Heart Valves / Q000473:pathology*; D006801:Humans; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D012306:Risk; D033081:Shear Strength; D012984:Software; D013314:Stress, Mechanical; D013923:Thromboembolism / Q000097:blood