title: The D-chiro-inositol paradox in the ovary.
abstract: The D-chiro-inositol-to-myo-inositol ratio is regulated by an insulin-dependent epimerase. Enzyme activity varies among tissues, likely owing to the specific needs of the two different molecules. We hypothesize that in the ovaries of polycystic ovary syndrome patients, epimerase activity is enhanced, leading to a local myo-inositol deficiency which in turn is responsible for the poor oocyte quality.
authors.affiliation: Associazione Ginecologi Unfer Costabile (AGUNCO) Obstetrics and Gynecology Center, Rome, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Carlomagno
authors.forename: Vittorio
authors.initials: V
authors.lastname: Unfer
authors.forename: Scott
authors.initials: S
authors.lastname: Roseff
mesh_terms: D005260:Female; D006801:Humans; D007294:Inositol / Q000378:metabolism* / Q000627:therapeutic use; D007328:Insulin / Q000378:metabolism; D010053:Ovary / Q000378:metabolism* / Q000503:physiopathology; D010060:Ovulation / Q000187:drug effects; D011085:Polycystic Ovary Syndrome / Q000378:metabolism* / Q000503:physiopathology; D019998:Racemases and Epimerases / Q000378:metabolism
chemical_list: D007328:Insulin; D007294:Inositol; D019998:Racemases and Epimerases