title: Serum apolipoprotein B-48 levels are correlated with carotid intima-media thickness in subjects with normal serum triglyceride levels.
abstract: BACKGROUND
  Postprandial hyperlipidemia (PPHL) is an independent risk factor for coronary heart disease (CHD) which is based on the accumulation of chylomicrons (CM) and CM remnants containing apolipoprotein B-48 (apoB-48). Since atherosclerotic cardiovascular diseases are frequently observed even in subjects with normal serum triglyceride (TG) level, the correlation between fasting apoB-48 containing lipoproteins and carotid intima-media thickness (IMT) was analyzed in subjects with normal TG levels.
  
  
  METHODS
  From subjects who took their annual health check at the Osaka Police Hospital (n=245, male), one-hundred and sixty-four male subjects were selected to take part in this study; the excluding factors were: systolic blood pressure ≥ 140 mmHg, intake of antihypertensive or antihyperlipidemic drugs, or age >65 years. The association between biochemical markers and IMT was analyzed and independent predictors of max-IMT were determined by multiple regression analysis in all subjects and in groups N-1 (TG<100mg/dl, n=58), N-2 (100 ≤ TG<150 mg/dl, n=53) and H (150 ≤ TG mg/dl, n=53), respectively.
  
  
  RESULTS
  Fasting total cholesterol, LDL-cholesterol, HDL-cholesterol, apoB-100 and lnRemL-C (remnant lipoprotein-cholesterol) levels were not correlated with max-IMT, but lnTG and lnapoB-48 were significantly correlated with max-IMT in all subjects. LnapoB-48 and apoB-48/TG ratio were significantly correlated with max-IMT in group N-2. By multiple regression analysis, age and lnapoB-48 were independent variables associated with max-IMT in group N-2.
  
  
  CONCLUSIONS
  Serum apoB-48 level might be a good marker for the detection of early atherosclerosis in middle-aged subjects with normal-range levels of blood pressure and TG.
authors.affiliation: Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakatani
authors.forename: Taizo
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Daisaku
authors.initials: D
authors.lastname: Masuda
authors.forename: Rieko
authors.initials: R
authors.lastname: Okano
authors.forename: Tomoko
authors.initials: T
authors.lastname: Oya
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Monden
authors.forename: Taiji
authors.initials: T
authors.lastname: Yamashita
authors.forename: Ryota
authors.initials: R
authors.lastname: Kawase
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakaoka
authors.forename: Miwako
authors.initials: M
authors.lastname: Inagaki
authors.forename: Miyako
authors.initials: M
authors.lastname: Yuasa-Kawase
authors.forename: Kazumi
authors.initials: K
authors.lastname: Tsubakio-Yamamoto
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohama
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishida
authors.forename: Masato
authors.initials: M
authors.lastname: Ishigami
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
authors.forename: Shizuya
authors.initials: S
authors.lastname: Yamashita
mesh_terms: D053283:Apolipoprotein B-48 / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood; D015415:Biomarkers; D001794:Blood Pressure; D059168:Carotid Intima-Media Thickness; D002784:Cholesterol / Q000097:blood; D002914:Chylomicrons / Q000097:blood; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D019518:Postprandial Period; D012044:Regression Analysis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D053283:Apolipoprotein B-48; D015415:Biomarkers; D002914:Chylomicrons; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol