title: Serum anti-Müllerian hormone, inhibin B, and total inhibin levels in women with hypothalamic amenorrhea and anorexia nervosa.
abstract: OBJECTIVE
  To evaluate whether neuroendocrine forms of secondary amenorrhea (hypothalamic nervosa (HA) and anorexia nervosa (AN)) affect serum anti-Müllerian hormone (AMH), inhibin B, and total inhibin levels.
  
  
  METHODS
  Amenorrheic women (n = 82) (aged between 16 and 35 years old) according to diagnosed with neuroendocrine forms of amenorrhea: HA (n = 64), AN (n = 18), and healthy women (n = 41) (control group) were enrolled. Serum AMH, inhibin B, and total inhibin levels were measured by specific ELISA.
  
  
  RESULTS
  No statistically significant difference of AMH serum levels between women with HA, AN, and control group was observed. Serum inhibin B and total inhibin levels in women with HA (p < 0.0001), AN (p < 0.05) resulted significantly lower than in control healthy women.
  
  
  CONCLUSIONS
  The present data showed that neuroendocrine forms of amenorrhea are associated with an impaired inhibin secretion while not AMH. These data indirectly support that AMH is an excellent marker of ovarian reserve and its secretion is not influenced by the hypothalamic-ovarian axis activity.
authors.affiliation: Division of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy. luisi@unisi.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Luisi
authors.forename: Valentina
authors.initials: V
authors.lastname: Ciani
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Podfigurna-Stopa
authors.forename: Lucia
authors.initials: L
authors.lastname: Lazzeri
authors.forename: Flavio
authors.initials: F
authors.lastname: De Pascalis
authors.forename: Blazej
authors.initials: B
authors.lastname: Meczekalski
authors.forename: Felice
authors.initials: F
authors.lastname: Petraglia
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000097:blood* / Q000209:etiology; D000856:Anorexia Nervosa / Q000097:blood* / Q000150:complications; D054304:Anti-Mullerian Hormone / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007027:Hypothalamic Diseases / Q000097:blood* / Q000150:complications; D007265:Inhibins / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000150:complications; D055815:Young Adult
chemical_list: C422364:inhibin B; D007265:Inhibins; D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone