title: Antifatigue activity of the liposoluble fraction from Acanthopanax senticosus.
abstract: The crude extract of Acanthopanax senticosus (AS) has been used extensively in Russia, China, Korea and Japan as an adaptogenic agent to fight against stress and fatigue. However, whether the liposoluble fraction possesses antifatigue activity or not is still unclear. A liposoluble fraction was administered orally to mice for 9 days. The swimming time to exhaustion was longer in the treatment groups (22.2 ± 3.3, 25.5 ± 4.8 min) than in the control group (13.7 ± 1.2 min, p < 0.05). The plasma TG (triglyceride) and BUN (blood urea nitrogen) levels in the high dose (500 mg/kg) groups were decreased significantly compared with the control group. Plasma lactate dehydrogenase (LDH) was lower in the treatment groups than in the control group. Chemical analysis from GC/MS revealed that the main components of the liposoluble fraction of AS were saturated fatty acid (12.98%), unsaturated fatty acid (33.13%), unsaturated alcohol (27.46%) and diolefine (15.76%). In conclusion, the liposoluble fraction enhanced the forced swimming capacity of mice by decreasing muscle damage, effectively preventing the increase in BUN concentration and increasing fat utilization. It is proposed that the antioxidant effect may be one of the antifatigue mechanisms of the liposoluble fraction of AS.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, PR China.
authors.forename: Lin-Zhang
authors.initials: LZ
authors.lastname: Huang
authors.forename: Bao-Kang
authors.initials: BK
authors.lastname: Huang
authors.forename: Jie
authors.initials: J
authors.lastname: Liang
authors.forename: Cheng-Jian
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Ting
authors.initials: T
authors.lastname: Han
authors.forename: Qiao-Yan
authors.initials: QY
authors.lastname: Zhang
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Qin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002681:China; D004305:Dose-Response Relationship, Drug; D028001:Eleutherococcus / Q000737:chemistry*; D005221:Fatigue / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010807:Physical Endurance / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D013550:Swimming
chemical_list: D000975:Antioxidants; D010936:Plant Extracts