title: Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population.
abstract: The purinergic 1 receptor (P2RY1) has been implicated in development of heart disease and in individual pharmacodynamic response to anticoagulant therapies. However, the association of polymorphisms in the P2RY1 gene with myocardial infarction (MI), and its associated conditions, has yet to be reported in the literature. We evaluated seven known SNPs in P2RY1 for association with MI in a Latvian population. Seven independent parameters that are related to MI [body mass index (BMI), type 2 diabetes (T2D), angina pectoris, hypertension, hyperlipidemia, atrial fibrillation and heart failure] were investigated. No significant association with MI was observed for any of the polymorphisms. Those SNPs for which the P value was close to significance were located in coding or promoter regions. Intriguingly, carriers of the minor allele in the P2RY1 gene locus showed a tendency towards higher onset age for MI, suggesting a possible protective effect of these SNPs against MI or their contribution in progression as opposed to onset. Finally, a linkage disequilibrium (LD) plot was generated for these polymorphisms in the Latvian population. The results of this study suggest that the role of P2RY1 in individuals from Latvian population is likely to be principally involved in platelet aggregation and thromboembolic diseases, and not as a significant contributing factor to the global metabolic syndrome.
authors.affiliation: Latvian Biomedical Research and Study Centre, Ratsupites str. 1, Riga 1067, Latvia. vita.ignatovica@biomed.lu.lv
authors.forename: Vita
authors.initials: V
authors.lastname: Ignatovica
authors.forename: Gustavs
authors.initials: G
authors.lastname: Latkovskis
authors.forename: Raitis
authors.initials: R
authors.lastname: Peculis
authors.forename: Kaspars
authors.initials: K
authors.lastname: Megnis
authors.forename: Helgi B
authors.initials: HB
authors.lastname: Schioth
authors.forename: Iveta
authors.initials: I
authors.lastname: Vaivade
authors.forename: Davids
authors.initials: D
authors.lastname: Fridmanis
authors.forename: Valdis
authors.initials: V
authors.lastname: Pirags
authors.forename: Andrejs
authors.initials: A
authors.lastname: Erglis
authors.forename: Janis
authors.initials: J
authors.lastname: Klovins
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007844:Latvia / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000235:genetics*; D010974:Platelet Aggregation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D058472:Receptors, Purinergic P2Y1 / Q000235:genetics*; D012307:Risk Factors; D013923:Thromboembolism / Q000235:genetics
chemical_list: C546382:P2RY1 protein, human; D058472:Receptors, Purinergic P2Y1