title: Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity.
abstract: A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared starting from 2,3-active functional pyridine 1via cyclization, propargylation followed by reaction with alkyl or perfluoroalkyl azides under Sharpless conditions. All the compounds 5 and 6 were screened for anticancer activity against three cancer cell lines such as U(937), THP-1 and Colo205. The promising compounds 5b and 5e have been identified.
authors.affiliation: Fluoroorganic Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
authors.forename: C
authors.initials: C
authors.lastname: Kurumurthy
authors.forename: P
authors.initials: P
authors.lastname: Sambasiva Rao
authors.forename: B
authors.initials: B
authors.lastname: Veera Swamy
authors.forename: G
authors.initials: G
authors.lastname: Santhosh Kumar
authors.forename: P
authors.initials: P
authors.lastname: Shanthan Rao
authors.forename: B
authors.initials: B
authors.lastname: Narsaiah
authors.forename: L R
authors.initials: LR
authors.lastname: Velatooru
authors.forename: R
authors.initials: R
authors.lastname: Pamanji
authors.forename: J
authors.initials: J
authors.lastname: Venkateswara Rao
mesh_terms: D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001386:Azides / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy / Q000473:pathology; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001386:Azides; D011743:Pyrimidines; D014230:Triazoles