title: Practical preparation of ethyl 2-methylthiophene-3-carboxylate.
abstract: A safe and efficient process for the preparation of ethyl 2-methylthiophene-3-carboxylate (5) was devised. This process provides several advantages over the precedents, involving operational simplicity, avoidance of the use of strong bases such as n-butyllithium and application of noncryogenic conditions, and enabled to prepare 5 in 52% overall yield from commercially available 2-methylthiophene on a multikilogram scale.
authors.affiliation: Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co. Ltd., 363 Shiosaki, Hokusei-cho, Mie, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kogami
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Watanabe
mesh_terms: D009942:Organometallic Compounds / Q000737:chemistry; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D013876:Thiophenes; C561144:ethyl 2-methylthiophene-3-carboxylate; C434823:n-butyllithium; C549318:thiophene-3-carboxylic acid