title: Immunologic mapping of glycomes: implications for cancer diagnosis and therapy.
abstract: Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.
authors.affiliation: Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. dzhou@mdanderson.org
authors.forename: Dapeng
authors.initials: D
authors.lastname: Zhou
authors.forename: Steven B
authors.initials: SB
authors.lastname: Levery
authors.forename: Fong-Fu
authors.initials: FF
authors.lastname: Hsu
authors.forename: Peng G
authors.initials: PG
authors.lastname: Wang
authors.forename: Susann
authors.initials: S
authors.lastname: Teneberg
authors.forename: Igor C
authors.initials: IC
authors.lastname: Almeida
authors.forename: Yunsen
authors.initials: Y
authors.lastname: Li
authors.forename: Huaxi
authors.initials: H
authors.lastname: Xu
authors.forename: Lai-Xi
authors.initials: LX
authors.lastname: Wang
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Xia
authors.forename: Nuhad K
authors.initials: NK
authors.lastname: Ibrahim
authors.forename: Katja
authors.initials: K
authors.lastname: Michael
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000954:Antigens, Surface / Q000378:metabolism*; D000939:Epitopes / Q000276:immunology / Q000378:metabolism; D037161:Galectins / Q000378:metabolism; D006001:Glycoconjugates / Q000276:immunology / Q000378:metabolism*; D054794:Glycomics / Q000379:methods*; D006801:Humans; D037102:Lectins / Q000378:metabolism; D037181:Lectins, C-Type / Q000378:metabolism; D013058:Mass Spectrometry / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D011134:Polysaccharides / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D000954:Antigens, Surface; D000939:Epitopes; D037161:Galectins; D006001:Glycoconjugates; D037102:Lectins; D037181:Lectins, C-Type; D011134:Polysaccharides; D011948:Receptors, Antigen, T-Cell; D063265:Sialic Acid Binding Immunoglobulin-like Lectins