title: Pregnancy outcome in female liver transplant recipients.
abstract: Transplantation has become an available and successful treatment option for numerous congenital and acquired hepatic disorders. Studies have shown that when the prepregnancy recipient graft function is stable and adequate, pregnancy is normally well tolerated with favorable neonatal outcomes. However, there are reports of increased incidences of hypertension and preeclampsia as well as lower birth weights and prematurity. Patients administered tacrolimus-based therapies seem to have lower incidences of these complications.
  
  
  METHODS
  The 5 reported patients, aged 23–37 years at the time of conception, were 2–11 years posttransplantation. A preterm delivery for fetal distress was the most clinically important complication among these patients. One episode of acute genital herpes infection, 1 liver hematoma in a patient who was anticoagulated owing to a history of deep vein thrombosis, and 1 case of wound infection postpartum were also observed. Despite these complications, all 5 pregnancies were successful. The mean gestational age at delivery was 35.2 weeks. No structural malformations or early complications were observed in the neonates. All cases showed stable liver parameters.
authors.affiliation: Department of Gynecology and Obstetrics, State University of Campinas, Campinas, Brazil.
authors.forename: M L B
authors.initials: ML
authors.lastname: Costa
authors.forename: F G C
authors.initials: FG
authors.lastname: Surita
authors.forename: R
authors.initials: R
authors.lastname: Passini
authors.forename: J G
authors.initials: JG
authors.lastname: Cecatti
authors.forename: I F S F
authors.initials: IF
authors.lastname: Boin
mesh_terms: D000328:Adult; D005260:Female; D005298:Fertility; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016031:Liver Transplantation / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D011256:Pregnancy Outcome; D013997:Time Factors; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents