title: Direct Effects of Ionizing Radiation on Macromolecules.
abstract: In the dry or frozen states, macromolecules are damaged directly by interactions with ionizing radiation. Since γ-rays and high-energy electrons randomly ionize orbital electrons in their path, larger molecules are more likely to suffer an interaction with these radiations. In each interaction, energy is transferred to the struck molecule, resulting in irreversibly broken covalent bonds. There is an extensive literature describing these radiation modifications in both synthetic and biopolymers. Although many different properties are measured, there emerges a similar picture of the nature of radiation damage that is common to all macromolecules. The techniques used in study of one species may be used to resolve questions raised in the other class of macromolecules.
authors.affiliation: National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda MD 20892.
authors.forename: E S
authors.initials: ES
authors.lastname: Kempner