title: A highly active and selective palladium pincer catalyst for the formation of α-aryl ketones via cross-coupling.
abstract: Several air and moisture stable Pd(II) pincer complexes were synthesized via oxidative addition of Pd(0) to novel PheBox pincer ligand precursors. Low loadings (1 mol%) of the Pd complex [t-BuPhebox-Me(2)]PdBr are capable of efficiently promoting the selective α-monoarylation of a variety of ketones with numerous aryl bromides in only 1 h at 70 °C with 82-99% yields.
authors.affiliation: Department of Chemistry, Texas A & M University, PO Box 30012, College Station, TX 77842-3012, USA.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Bugarin
authors.forename: Brian T
authors.initials: BT
authors.lastname: Connell