title: Stereoselective synthesis of core structure of cortistatin A.
abstract: A stereoselective synthesis of the core structure of cortistatin A (1), a novel antiangiogenic steroidal alkaloid from Indonesian marine sponge, is described. An 8-oxabicyclo[3.2.1]octene system, a characteristic B-ring structure of 1, was elaborated by a 7-endo selective intramolecular Heck cyclization and a subsequent acid-mediated oxy-Michael reaction.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. kotoku@phs.osaka-u.ac.jp
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kotoku
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sumii
authors.forename: Motomasa
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D003500:Cyclization; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D011083:Polycyclic Compounds; C531521:cortistatin A