title: Inflammatory links between obesity and metabolic disease.
abstract: The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that they are inextricably linked. The reframing of obesity as an inflammatory condition has had a wide impact on our conceptualization of obesity-associated diseases. In this Review, we highlight the cellular and molecular mechanisms at play in the generation of obesity-induced inflammation. We also emphasize how defining the immune regulation in metabolic tissues has broadened the understanding of the diversity of inflammatory responses.
authors.affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan 48109-5652, USA. clumeng@umich.edu
authors.forename: Carey N
authors.initials: CN
authors.lastname: Lumeng
authors.forename: Alan R
authors.initials: AR
authors.lastname: Saltiel
mesh_terms: D000209:Acute-Phase Proteins / Q000502:physiology; D000273:Adipose Tissue / Q000503:physiopathology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D016207:Cytokines / Q000502:physiology; D018450:Disease Progression; D004734:Energy Metabolism / Q000502:physiology; D005355:Fibrosis; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D007962:Leukocytes / Q000502:physiology; D008099:Liver / Q000378:metabolism; D008264:Macrophages / Q000502:physiology; D008659:Metabolic Diseases / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D009928:Organ Specificity; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology
chemical_list: D000209:Acute-Phase Proteins; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D047492:Peroxisome Proliferator-Activated Receptors