title: Domestic exposure to aeroallergens in Hong Kong families with asthmatic children.
abstract: Indoor aeroallergen exposures increased asthma symptoms in Caucasians, but their determinants and relationship to asthma and allergy in Asians are unclear. This study investigated exposures to cat, cockroach, and Blomia tropicalis allergens in 115 Hong Kong families with asthmatic children. Patients underwent exhaled nitric oxide and spirometric measurements. Home visits were made within 2 weeks during which parents completed a standardized questionnaire. Fel d 1, Bla g 2, and Blo t 5 in dust samples collected from patients' mattresses, bedroom floors, and living room floors were measured by immunoassays. These aeroallergens were only detectable in some homes (38-55% for Fel d 1; 9-21% for Bla g 2, and 7-14% for Blo t 5). The presence of cat and/or dog was a strong determinant for Fel d 1 in all indoor sites. The timing and frequency of bedding change was associated with Bla g 2 levels, whereas the timing of bedroom floor cleaning was a consistent factor for Blo t 5 levels. Asthmatic children in families with high allergen exposure were more likely to have ≥4 wheezing attacks in preceding 12 months and exercise-induced wheezing than those with normal allergen exposure (P = 0.051 and 0.030, respectively). Mattress levels of all three allergens were also associated with severity of several allergy symptoms (P = 0.025-0.005). None of these aeroallergens correlated with exhaled nitric oxide and spirometric parameters. This study identifies determinants for cat, cockroach, and B. tropicalis levels in Hong Kong families with asthmatic children. These exposures are associated with severity of allergy symptoms.
authors.affiliation: Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: Ting F
authors.initials: TF
authors.lastname: Leung
authors.forename: Yun S
authors.initials: YS
authors.lastname: Wong
authors.forename: Iris H S
authors.initials: IH
authors.lastname: Chan
authors.forename: Edmund
authors.initials: E
authors.lastname: Yung
authors.forename: Hing Y
authors.initials: HY
authors.lastname: Sy
authors.forename: Christopher W K
authors.initials: CW
authors.lastname: Lam
authors.forename: Gary W K
authors.initials: GW
authors.lastname: Wong
mesh_terms: D000293:Adolescent; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000485:Allergens / Q000032:analysis*; D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000276:immunology; D001944:Breath Tests; D002415:Cats; D002648:Child; D003058:Cockroaches; D004285:Dogs; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D006723:Hong Kong; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008925:Mites; D009569:Nitric Oxide / Q000032:analysis; D013147:Spirometry
chemical_list: D000485:Allergens; D009569:Nitric Oxide