title: Bone phenotypes of P2 receptor knockout mice.
abstract: The action of extracellular nucleotides is mediated by ionotropic P2X receptors and G-protein coupled P2Y receptors. The human genome contains 7 P2X and 8 P2Y receptor genes. Knockout mice strains are available for most of them. As their phenotypic analysis is progressing, bone abnormalities have been observed in an impressive number of these mice: distinct abnormalities in P2X7-/- mice, depending on the gene targeting construct and the genetic background, decreased bone mass in P2Y1-/- mice, increased bone mass in P2Y2-/- mice, decreased bone resorption in P2Y6-/- mice, decreased bone formation and bone resorption in P2Y13-/- mice. These findings demonstrate the unexpected importance of extracellular nucleotide signalling in the regulation of bone metabolism via multiple P2 receptors and distinct mechanisms involving both osteoblasts and osteoclasts.
authors.affiliation: Department of Cell and Developmental Biology, University College London, London, UK.
authors.forename: Isabel
authors.initials: I
authors.lastname: Orriss
authors.forename: Susanne
authors.initials: S
authors.lastname: Syberg
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Bernard
authors.initials: B
authors.lastname: Robaye
authors.forename: Alison
authors.initials: A
authors.lastname: Gartland
authors.forename: Niklas
authors.initials: N
authors.lastname: Jorgensen
authors.forename: Tim
authors.initials: T
authors.lastname: Arnett
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Boeynaems
mesh_terms: D000818:Animals; D015519:Bone Density / Q000235:genetics; D001862:Bone Resorption / Q000235:genetics; D001842:Bone and Bones / Q000002:abnormalities* / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009711:Nucleotides / Q000378:metabolism; D010641:Phenotype; D018048:Receptors, Purinergic P2 / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D009711:Nucleotides; D018048:Receptors, Purinergic P2