title: PPARγ: a molecular link between systemic metabolic disease and benign prostate hyperplasia.
abstract: The emergent epidemic of metabolic syndrome and its complex list of sequelae mandate a more thorough understanding of benign prostatic hyperplasia and lower urinary tract symptoms (BPH/LUTS) in the context of systemic metabolic disease. Here we discuss the nature and origins of BPH, examine its role as a component of LUTS and review retrospective clinical studies that have drawn associations between BPH/LUTS and type II diabetes, inflammation and dyslipidemia. PPARγ signaling, which sits at the nexus of systemic metabolic disease and BPH/LUTS through its regulation of inflammation and insulin resistance, is proposed as a candidate for molecular manipulation in regard to BPH/LUTS. Finally, we introduce new cell and animal models that are being used to study the consequences of obesity, diabetes and inflammation on benign prostatic growth.
authors.affiliation: Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA. ming.jiang.1@vanderbilt.edu
authors.forename: Ming
authors.initials: M
authors.lastname: Jiang
authors.forename: Douglas W
authors.initials: DW
authors.lastname: Strand
authors.forename: Omar E
authors.initials: OE
authors.lastname: Franco
authors.forename: Peter E
authors.initials: PE
authors.lastname: Clark
authors.forename: Simon W
authors.initials: SW
authors.lastname: Hayward
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000473:pathology; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000150:complications / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000473:pathology; D059411:Lower Urinary Tract Symptoms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D058990:Molecular Targeted Therapy; D047495:PPAR gamma / Q000235:genetics* / Q000378:metabolism*; D011467:Prostate / Q000033:anatomy & histology / Q000254:growth & development / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D047495:PPAR gamma