title: [Risk factors affecting in-hospital mortality of the arterial switch operation for transposition of the great arteries].
abstract: OBJECTIVE
  To analyze the in-hospital mortality and factors affecting in-hospital mortality for patients with transposition of the great arteries (TGA) undergoing arterial switch operation (ASO).
  
  
  METHODS
  Between January 2004 and December 2007, ASO was performed in 169 patients [129 male, 40 female; mean age (11.71 ± 26.3) months] with TGA. The patients were divided in intact ventricular septum group (n = 56): TGA with intact ventricular septum and ventricular septal defect group (n = 113): TGA with ventricular septal defect. Multiple logistic regression analysis was performed to identify the risk factors of in-hospital mortality.
  
  
  RESULTS
  The overall in-hospital mortality was 11.24% (19/169). The yearly in-hospital mortality was similar between intact ventricular septum group and ventricular septal defect group. With the improvement of perioperative treatment, the in-hospital mortality decreased from 16.67% in 2004 to 3.92% in 2007. The multivariate analysis revealed that body weight ≤ 3 kg (OR: 4.571, P = 0.0409), complicating ventricular septal defect (OR: 4.444, P = 0.0406), complex TGA (OR: 4.321, P = 0.0140), coronary anomalies (OR: 4.867, P = 0.0104) and non-type A coronary arteries (OR: 3.045, P = 0.0243) were independent predictors for poor early postoperative survival.
  
  
  CONCLUSIONS
  Body weight ≤ 3 kg, complicating ventricular septal defect, complex TGA, coronary anomalies are independent predictors for increased in-hospital mortality in patients with transposition of TGA and undergoing arterial switch operation.
authors.affiliation: Department of Surgery, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Xiang-bin
authors.initials: XB
authors.lastname: Pan
authors.forename: Sheng-shou
authors.initials: SS
authors.lastname: Hu
authors.forename: Shou-jun
authors.initials: SJ
authors.lastname: Li
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zheng
authors.forename: Ya-juan
authors.initials: YJ
authors.lastname: Zhnag
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.forename: Ye
authors.initials: Y
authors.lastname: Lin
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001158:Arteries / Q000601:surgery*; D001835:Body Weight; D006348:Cardiac Surgical Procedures / Q000401:mortality*; D002675:Child, Preschool; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000401:mortality / Q000601:surgery; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D012307:Risk Factors; D014188:Transposition of Great Vessels / Q000401:mortality / Q000601:surgery*