title: A postmenopause-like model of ovariectomized Wistar rats to identify active principles of Erythrina lysistemon (Fabaceae).
abstract: To determine whether the two major compounds of Erythrina lysistemon are active principles accounting for Erythrina estrogenic effects, we used a postmenopause-like model of ovariectomized Wistar rats to evaluate their effects on some menopausal problems. Ovariectomized rats were orally treated either with compound 1 or compound 2 at 1 and 10 mg/kg BW for 28 days. Estradiol valerate served as the reference substance. As results, compounds 1 and 2 displayed estrogen-like effects on the uterus and the vagina, and reduced atherogenic risks by decreasing the two assessed atherogenic parameters, the total cholesterol/HDL-cholesterol ratio and the atherogenic index of plasma.
authors.affiliation: Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaounde I, Yaounde, Cameroon.
authors.forename: M A
authors.initials: MA
authors.lastname: Mvondo
authors.forename: D
authors.initials: D
authors.lastname: Njamen
authors.forename: S Tanee
authors.initials: ST
authors.lastname: Fomum
authors.forename: J
authors.initials: J
authors.lastname: Wandji
authors.forename: Günter
authors.initials: G
authors.lastname: Vollmer
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004895:Erythrina / Q000737:chemistry*; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D023421:Models, Animal; D010052:Ovariectomy; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D017698:Postmenopause; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D014599:Uterus / Q000187:drug effects*; D014621:Vagina / Q000187:drug effects*
chemical_list: D008076:Cholesterol, HDL; D004967:Estrogens; D010936:Plant Extracts; D004958:Estradiol; D002784:Cholesterol