title: Effects of oligodeoxynucleotide with CCT repeats on chronic graft versus host disease induced experimental lupus nephritis in mice.
abstract: A synthesized single-stranded oligodeoxynucleotide (ODN), designed as SAT05f with the sequence of human microsatellite DNA, has been studied for its capacity of alleviating the lupus nephritis in the chronic graft versus host disease (cGVHD) induced lupus-prone mice. In cGVHD model mice, both of continuous and discontinuous treatment with SAT05f was effective on reducing anti-ssDNA antibody production, decreasing renal IgG deposition and delaying the onset of lupus nephritis. In addition, SAT05f could down-regulate TLR9 mRNA expression in splenocytes of cGVHD model mice. These results indicated that SAT05f could be developed as a new therapeutic agent for the treatment of lupus nephritis by inhibiting TLR9 signaling pathways.
authors.affiliation: Department of Immunology, Norman Bethune Medical College, Jilin University, Changchun 130021, PR China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: He
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.forename: Ran
authors.initials: R
authors.lastname: Sun
authors.forename: Tiesuo
authors.initials: T
authors.lastname: Zhao
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu
authors.forename: Liying
authors.initials: L
authors.lastname: Wang
authors.forename: Yongli
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004277:DNA, Single-Stranded / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008181:Lupus Nephritis / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018895:Microsatellite Repeats / Q000235:genetics; D009838:Oligodeoxyribonucleotides / Q000276:immunology / Q000627:therapeutic use*; D051217:Toll-Like Receptor 9 / Q000096:biosynthesis / Q000276:immunology
chemical_list: D004277:DNA, Single-Stranded; D007074:Immunoglobulin G; D009838:Oligodeoxyribonucleotides; C561797:SAT05f; C495370:Tlr9 protein, mouse; D051217:Toll-Like Receptor 9