title: [Effects on serum myelin proteins of n-hexane exposure].
abstract: OBJECTIVE
  Exploring the effects of n-hexane on expression of serum myelin proteins in occupational exposure workers, and finding the early biomarker of n-hexane exposure.
  
  
  METHODS
  In the study, 373 subjects were recruited, 269 exposure workers (work experience of more than1 year) and 104 non-exposure workers were selected. Firstly examined the level of urinary 2,5-hexanedione in the two groups, based on urinary 2,5-hexanedione biological limit value (4 mg/L), the exposed group was divided into high-exposed group and low-exposed group. And then collected blood samples and extracted serum. Human peripheral myelin protein zero (P0) antibody (IgG, IgM) and human peripheral myelin protein two (P2) antibody (IgG, IgM) analysis was performed according to ELISA kit.
  
  
  RESULTS
  The concentration of urinary 2,5-hexanedione in the exposed group was (3.10 ± 1.35) mg/L. The level of P0 antibody (IgG, IgM) and P2 antibody (IgG, IgM) in the high-exposed group and low-exposed group were both higher than that in the controls (P < 0.01).
  
  
  CONCLUSIONS
  P0 antibody and P2 antibody could be used as the early biomarkers of n-hexane exposure, which not only evaluate the occupational hazards in the early, but also provide the policy maker with scientific evidence.
authors.affiliation: Shenzhen Institute of Occupational Disease Treatment and Prevention, Shenzhen 518001, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yi
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Jia-xi
authors.initials: JX
authors.lastname: He
authors.forename: Qing-jun
authors.initials: QJ
authors.lastname: Liu
authors.forename: Xian-qing
authors.initials: XQ
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D035061:Control Groups; D005260:Female; D006586:Hexanes / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009185:Myelin Proteins / Q000276:immunology*; D016273:Occupational Exposure; D055815:Young Adult
chemical_list: D000906:Antibodies; D015415:Biomarkers; D006586:Hexanes; D009185:Myelin Proteins; C026385:n-hexane