title: Central nervous system agents and erectile dysfunction.
abstract: Several centrally acting agents have shown potential to improve erectile function in men with ED. They still lack adequate data in efficacy and tolerability. Nasal formulations of apomorphine and bremelanotide seem to be the most likely candidates for future approval. They may play a role, specifically in men who fail phosphodiesterase 5 (PDE5) therapy, are unable to take PDE5 inhibitors because of side effects, or are on nitrate therapy. This article reviews the centrally acting agents and the data on their efficacy.
authors.affiliation: Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Kumar
authors.forename: Ajay
authors.initials: A
authors.lastname: Nehra
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage / Q000627:therapeutic use; D001058:Apomorphine / Q000008:administration & dosage / Q000627:therapeutic use*; D002491:Central Nervous System Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018491:Dopamine Agonists / Q000627:therapeutic use*; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D053486:Melanocortins / Q000008:administration & dosage / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use; D010410:Penile Erection / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D000521:alpha-MSH / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000596:Amino Acids; D001058:Apomorphine; D002491:Central Nervous System Agents; D018491:Dopamine Agonists; D053486:Melanocortins; D009569:Nitric Oxide; D010456:Peptides, Cyclic; D058986:Phosphodiesterase 5 Inhibitors; D017367:Selective Serotonin Reuptake Inhibitors; D000521:alpha-MSH; C476721:bremelanotide