title: Detecting small lung tumors in mouse models by refractive-index microradiology.
abstract: Refractive-index (phase-contrast) radiology was able to detect lung tumors less than 1 mm in live mice. Significant micromorphology differences were observed in the microradiographs between normal, inflamed, and lung cancer tissues. This was made possible by the high phase contrast and by the fast image taking that reduces the motion blur. The detection of cancer and inflammation areas by phase contrast microradiology and microtomography was validated by bioluminescence and histopathological analysis. The smallest tumor detected is less than 1 mm(3) with accuracy better than 1 × 10(-3) mm(3). This level of performance is currently suitable for animal studies, while further developments are required for clinical application.
authors.affiliation: Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan.
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Chien
authors.forename: Guilin
authors.initials: G
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Hwu
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Weisheng
authors.initials: W
authors.lastname: Yue
authors.forename: Jianqi
authors.initials: J
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Hongjie
authors.initials: H
authors.lastname: Xu
authors.forename: Hongjie
authors.initials: H
authors.lastname: Xue
authors.forename: Lisa X
authors.initials: LX
authors.lastname: Xu
authors.forename: Chang Hai
authors.initials: CH
authors.lastname: Wang
authors.forename: Nanyow
authors.initials: N
authors.lastname: Chen
authors.forename: Chien Hung
authors.initials: CH
authors.lastname: Lu
authors.forename: Ting-Kuo
authors.initials: TK
authors.lastname: Lee
authors.forename: Yuh-Cheng
authors.initials: YC
authors.lastname: Yang
authors.forename: Yen-Ta
authors.initials: YT
authors.lastname: Lu
authors.forename: Yu-Tai
authors.initials: YT
authors.lastname: Ching
authors.forename: T F
authors.initials: TF
authors.lastname: Shih
authors.forename: P C
authors.initials: PC
authors.lastname: Yang
authors.forename: J H
authors.initials: JH
authors.lastname: Je
authors.forename: G
authors.initials: G
authors.lastname: Margaritondo
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D045744:Cell Line, Tumor; D003094:Collagen / Q000737:chemistry; D004195:Disease Models, Animal; D005910:Glioma / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D051379:Mice; D011859:Radiography; D051381:Rats; D012015:Reference Standards; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D003094:Collagen