title: Primary colorectal lymphoma-clinical outcomes in a population-based series.
abstract: OBJECTIVE
  The purpose of this study was to investigate the characteristics and the outcomes of primary colorectal lymphomas using a population-based registry.
  
  
  METHODS
  All cases of colorectal lymphoma diagnosed between 1980 and 2007 were identified using a provincial cancer registry. Patients meeting Dawson's criteria and having a negative bone marrow biopsy were included.
  
  
  RESULTS
  One hundred ten cases of colorectal lymphoma were identified, 43 met the inclusion criteria. The majority of patients was male (86%), and the median age at diagnosis was 62 (range 26-82) years. Tumors were mostly located in the cecum (51.1%) and rectum (20.9%). The 5-year overall survival rate calculated by the Kaplan-Meier method was 57%. Age under 60 was associated with a better median survival time (265 vs 54 months; p < 0.0001). The surgical treatment was associated with a better overall survival compared to medical treatment alone (110 vs 56 months; p = 0.083). Tumors located in the rectum were associated with a decreased overall survival (41 months vs 110 months; p = 0.065).
  
  
  CONCLUSIONS
  Primary colorectal lymphoma is a rare disease. The age at diagnosis is an important predictor of outcome. Surgical resection may be associated with improved survival. Rectal lymphoma appears to be associated with a worse outcome and may warrant more aggressive therapy.
authors.affiliation: Department of Surgery, University of Calgary, Calgary, AB, Canada.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Drolet
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Maclean
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Stewart
authors.forename: Elijah
authors.initials: E
authors.lastname: Dixon
authors.forename: Elizabeth Oddone
authors.initials: EO
authors.lastname: Paolucci
authors.forename: W Donald
authors.initials: WD
authors.lastname: Buie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000416:Alberta; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome