title: Development and characterization of rifampicin loaded floating microspheres.
abstract: Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs.
authors.affiliation: Nanomedicine Research Centre, Department of Pharmaceutics, Indo-Soviet Friendship College of Pharmacy, Moga (Punjab), India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Goyal
authors.forename: S
authors.initials: S
authors.lastname: Gill
authors.forename: U D
authors.initials: UD
authors.lastname: Gupta
authors.forename: Goutam
authors.initials: G
authors.lastname: Rath
authors.forename: Raj K
authors.initials: RK
authors.lastname: Narang
authors.forename: Amit K
authors.initials: AK
authors.lastname: Goyal
mesh_terms: D000284:Administration, Oral; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000627:therapeutic use*; D001682:Biological Availability; D002482:Cellulose / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D004339:Drug Compounding / Q000379:methods*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000502:physiology; D010316:Particle Size; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use*; D012997:Solvents / Q000737:chemistry; D013270:Stomach / Q000187:drug effects; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000904:Antibiotics, Antitubercular; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012997:Solvents; D002482:Cellulose; D012293:Rifampin