title: Synthesis and screening of (E)-1-(β-D-galactopyranosyl)-4-(aryl)but-3-ene-2-one against Mycobacterium tuberculosis.
abstract: A series of galactose-derived aryl enones were synthesised and screened against Mycobacterium tuberculosis H(37)Rv. Preliminary results were promising with MIC values in the range 1.56-12.5 μg/mL.
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab 160062, India.
authors.forename: G
authors.initials: G
authors.lastname: Mugunthan
authors.forename: Kuppala
authors.initials: K
authors.lastname: Ramakrishna
authors.forename: Dharmarajan
authors.initials: D
authors.lastname: Sriram
authors.forename: Perumal
authors.initials: P
authors.lastname: Yogeeswari
authors.forename: K P
authors.initials: KP
authors.lastname: Ravindranathan Kartha
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005690:Galactose / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D011714:Pyrans; D005690:Galactose