title: Addressing brain tumors with targeted gold nanoparticles: a new gold standard for hydrophobic drug delivery?
abstract: EGF-modified Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF-Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers.
authors.affiliation: Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA, Fax: (+1) 216-368-3006.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cheng
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Meyers
authors.forename: Richard S
authors.initials: RS
authors.lastname: Agnes
authors.forename: Tennyson L
authors.initials: TL
authors.lastname: Doane
authors.forename: Malcolm E
authors.initials: ME
authors.lastname: Kenney
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Broome
authors.forename: Clemens
authors.initials: C
authors.lastname: Burda
authors.forename: James P
authors.initials: JP
authors.lastname: Basilion
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations; D004815:Epidermal Growth Factor / Q000737:chemistry / Q000493:pharmacokinetics*; D066246:ErbB Receptors / Q000378:metabolism; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism; D006046:Gold / Q000627:therapeutic use*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007211:Indoles / Q000008:administration & dosage / Q000737:chemistry; D054833:Isoindoles; D053768:Metal Nanoparticles / Q000627:therapeutic use* / Q000648:ultrastructure; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry / Q000648:ultrastructure; D058726:Nanoconjugates / Q000627:therapeutic use / Q000648:ultrastructure; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D003692:Delayed-Action Preparations; D007211:Indoles; D054833:Isoindoles; D053769:Nanocapsules; D058726:Nanoconjugates; D017319:Photosensitizing Agents; D004815:Epidermal Growth Factor; D006046:Gold; D066246:ErbB Receptors; C013647:phthalocyanine