title: Parietofrontal circuits in goal-oriented behaviour.
abstract: Parietal and frontal cortical areas play important roles in the control of goal-oriented behaviour. This review examines how signal processing in the parietal and frontal eye fields is involved in coding and storing space, directing attention and processing the sensorimotor transformation for saccades. After a survey of the functional specialization of these areas in monkeys, we discuss homologous regions in the human brain in terms of topographic organization, storage capacity, target selection, spatial remapping, reference frame transformations and effector specificity. The overall picture suggests that bottom-up sensory, top-down cognitive signals and efferent motor signals are integrated in dynamic sensorimotor maps as part of a functionally flexible parietofrontal network. Neuronal synchronization in these maps may be instrumental in amplifying behaviourally relevant representations and setting up a functional pathway to route information in this parietofrontal circuit.
authors.affiliation: Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, NL 6500 HE, Nijmegen, The Netherlands. p.medendorp@donders.ru.nl
authors.forename: W Pieter
authors.initials: WP
authors.lastname: Medendorp
authors.forename: Verena N
authors.initials: VN
authors.lastname: Buchholz
authors.forename: Jurrian
authors.initials: J
authors.lastname: Van Der Werf
authors.forename: Frank T M
authors.initials: FT
authors.lastname: Leoné
mesh_terms: D000818:Animals; D005625:Frontal Lobe / Q000502:physiology*; D006040:Goals; D000882:Haplorhini; D006801:Humans; D009434:Neural Pathways / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D012438:Saccades / Q000502:physiology; D013028:Space Perception / Q000502:physiology