title: Glioblastoma multiforme: enhancing survival and quality of life.
abstract: A diagnosis of a malignant brain tumor is devastating to patients and their families. The patients' inevitable loss of independence, which can occur suddenly or gradually, is tragic, and the eventual complete dependence can be overwhelming to the family and caregivers. Glioblastoma multiforme (GBM) is the most common type of primary malignant brain tumor in adults and is associated with a disproportionately high mortality rate. The highly malignant tumor grows rapidly and has a tendency to recur through treatment. The brain itself presents a multitude of barriers to treatment, such as tumor location, accessibility for surgery, and the blood-brain barrier's natural protection. Despite access to optimal multimodality treatment, patients diagnosed with GBM have a low survival rate. Patients and families need emotional and practical support throughout the continuum of this devastating disease. Astute neurologic assessment skills and immediate and appropriate interventions are required to maintain the patient's functional status. This article provides an overview of the treatment of GBM and reviews how oncology nurses can intervene to positively improve the quality of life of patients and their families.
authors.affiliation: Department of Ambulatory Nursing, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. davism@mskcc.org
authors.forename: Mary Elizabeth
authors.initials: ME
authors.lastname: Davis
authors.forename: Ann Marie Mulligan
authors.initials: AM
authors.lastname: Stoiber
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005909:Glioblastoma / Q000401:mortality* / Q000451:nursing / Q000523:psychology; D006801:Humans; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011788:Quality of Life / Q000523:psychology*; D011878:Radiotherapy; D012640:Seizures; D000077204:Temozolomide; D014481:United States; D054556:Venous Thromboembolism
chemical_list: D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide