title: Human diurnal preference and circadian rhythmicity are not associated with the CLOCK 3111C/T gene polymorphism.
abstract: Genetic association studies of the CLOCK 3111C/T polymorphism and diurnal preference have yielded conflicting results since the first report that the 3111C allele was associated with eveningness. The goal of the present study was to investigate the association of this polymorphism with diurnal preference and circadian physiology in a group of 179 individuals, by comparing the frequency of the 3111C allele to diurnal preference, habitual sleep timing, circadian phase markers, and circadian period. We did not find a significant association between this allele and morningness/eveningness or any circadian marker.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Chang
authors.forename: Alison M
authors.initials: AM
authors.lastname: Buch
authors.forename: Dayna S
authors.initials: DS
authors.lastname: Bradstreet
authors.forename: David J
authors.initials: DJ
authors.lastname: Klements
authors.forename: Jeanne F
authors.initials: JF
authors.lastname: Duffy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D056926:CLOCK Proteins / Q000235:genetics*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000378:metabolism; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012890:Sleep / Q000235:genetics; D055815:Young Adult
chemical_list: D056926:CLOCK Proteins; C538943:CLOCK protein, human; D008550:Melatonin