title: [The effect of sevoflurane inhalation anesthesia only and propofol total intravenous anesthesia on perioperative cytokine balance in lung cancer patients].
abstract: OBJECTIVE
  To investigate the effects of sevoflurane inhalation anesthesia only and propofol total intravenous anesthesia on perioperative cytokine balance in lung cancer patients.
  
  
  METHODS
  ASA I or II patients undergoing lobectomy for lung cancer were randomly divided into two groups with 45 cases each. In group A, patients received g sevoflurane inhalation anesthesia only and patients in group B received propofol total intravenous anesthesia. The cervical venous blood samples were obtained at the following time points: before induetion of anesthesia(T0), before the start of one-lung ventilation(T1), before the end of one-lung ventilation(T2), after closed chest surgery(T3), after 24 h (T4) . The serum concentrations of IL-6, IL-8 and IL-10 were measured by ELISA.
  
  
  RESULTS
  (1) In both groups the concentration of IL-6 increased at T1 and kept raising to a high level at T4 which showed significant differences with that of pre-operation(P < 0.05).Compared between the groups, the concentration of IL-6 at T1 and T2 in group B was lower than that of group A(P < 0.05). (2) In both groups the concentration of IL-8 kept at T1 and T3 which were significant with that of pre-operation(P < 0.01). The concentration of IL-8 decreased apparantly at T4 in both groups, it was significant with that of pre-operation though(P < 0.01).Compared between the groups, the concentration of IL-8 at T1, T2 and T3 in group B were all lower than that of group A (P < 0.05). (3) In both groups the concentration of IL-10 increased at T1 which was significant with that of pre-operation(P < 0.05)and kept at T2 and T3. It dropped somehow at T4 but still maintained at a high level.Compared between the groups, the concentration of IL-10 in group B at T1, T2, T3 and T4 was singicantly higher than that of group A(P < 0.05).
  
  
  CONCLUSIONS
  Propofol causes less inflammatory mediator release and can also modulate the balance of cytokines. It is a better anesthetic for lung cancer than sevoflurane.
authors.affiliation: General Surgery, Affiliated Xiangya Hospital, Central South University, Changsha 410008, China. huxiaoling0123@126.com
authors.forename: Xiao-ling
authors.initials: XL
authors.lastname: Hu
authors.forename: Hui-huan
authors.initials: HH
authors.lastname: Tang
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Yin
authors.forename: Wen-jie
authors.initials: WJ
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D016207:Cytokines / Q000097:blood* / Q000187:drug effects*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism; D016209:Interleukin-8 / Q000097:blood / Q000378:metabolism; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D008875:Middle Aged; D059035:Perioperative Period; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D013510:Pulmonary Surgical Procedures; D000077149:Sevoflurane; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000187:drug effects
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D008738:Methyl Ethers; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D000077149:Sevoflurane; D015742:Propofol