title: Refractory anemia as a presenting feature of microscopic polyangiitis: a rare vasculitis in children.
abstract: Microcytic anemia refractory to usual supplementation is an important clue to an alternative diagnosis. Accompanying pulmonary and renal involvement during the disease course suggests a multisystem disease. Small-vessel vasculitis should be suspected in any patient who presents with a multisystem disease that is not caused by an infectious or malignant process. Among these, antineutrophilic cytoplasmic antibodies (ANCA)-associated vasculitis is a distinct subclass involving anti-neutrophil cytoplasmic antibody (ANCA) as the common pathogenesis. Microscopic polyangiitis is a rare form of such vasculitis in children characterized by pulmonary-renal syndrome with pauci-imune rapidly progressive glomerulonephritis and a poor outcome.
authors.affiliation: Department of Pediatrics, Government Medical College, Sector 32 Chandigarh, India. geetanjali_jindal@yahoo.com
authors.forename: Geetanjali
authors.initials: G
authors.lastname: Jindal
authors.forename: Sanjay D
authors.initials: SD
authors.lastname: Cruz
authors.forename: R P S
authors.initials: RP
authors.lastname: Punia
authors.forename: Ravinder
authors.initials: R
authors.lastname: Kaur
mesh_terms: D000753:Anemia, Refractory / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D055953:Microscopic Polyangiitis / Q000175:diagnosis*