title: [Genetic profiles of longevity and healthy cognitive aging in nonagenarians from the Basque Country].
abstract: BACKGROUND
  Currently there are notable differences in the aging of individuals in modern populations. While some of them enjoy a long healthy aging, others develop neurodegenerative diseases, such as Alzheimer's disease (AD). Environmental factors are critical, but genetics could explain the differences observed. It has recently been postulated that longevity genes might also be neuroprotective.
  
  
  OBJECTIVE
  To assess whether certain genetic variants associated with longevity might have a neuroprotective effect.
  
  
  METHODS
  The subjects of this study are people older than 90 years. We will collect sociodemographic and clinical data and multiple assessments, cognitive, functional, anthropometric, nutritional, sensory and physical each participant. In addition, 64 SNPs loci distributed in 13 candidate genes FOXO3, SIRT1, TOMM40, APOE, PICALM, COMT, CETP, CLU, CR1, IL-6, PCK-1, ZNF224 and ACE will be analysed by Taqman array.
  
  
  RESULTS
  It is hoped to gain more knowledge about under/over-represented alleles in nonagenarians. Furthermore, comparison of the genetic characteristics of nonagenarians with AD with those free of disease will enable links to be seen between certain alleles with protection or the risk of AD. Associated information on the participants will create subgroups showing the interactions between environment and genetic variation in relation to healthy aging and AD.
  
  
  CONCLUSIONS
  The study of the genetic variability of nonagenarians can give us information on the alleles associated with longevity and neuroprotection.
authors.affiliation: Grupo de Investigación BIOMICS, Departamento de Z. y Biología Celular A, Centro de Investigación y Estudios Avanzados - CIEA «Lucio Lascaray», Universidad del País Vasco UPV/EHU, Vitoria-Gasteiz, Álava, España.
authors.forename: Xabier
authors.initials: X
authors.lastname: Elcoroaristizabal Martín
authors.forename: Fernando
authors.initials: F
authors.lastname: Gómez Busto
authors.forename: Iñaki
authors.initials: I
authors.lastname: Artaza Artabe
authors.forename: Julia
authors.initials: J
authors.lastname: Barroso Niso
authors.forename: Javier
authors.initials: J
authors.lastname: Goicoechea Boyer
authors.forename: Víctor Ortiz de Murua
authors.initials: VO
authors.lastname: García de Vicuña
authors.forename: Marian
authors.initials: M
authors.lastname: Martínez de Pancorbo
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D003071:Cognition; D005260:Female; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D011446:Prospective Studies; D013030:Spain