title: Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4.
abstract: A sequential Pd-mediated multi-component reaction followed by Suzuki or Heck or Sonogashira coupling in a single pot has been developed for the synthesis of functionalized pyrroles as potential inhibitors of PDE4.
authors.affiliation: Custom Pharmaceutical Services, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500 049, India.
authors.forename: G Rajeshwar
authors.initials: GR
authors.lastname: Reddy
authors.forename: T Ram
authors.initials: TR
authors.lastname: Reddy
authors.forename: Suju C
authors.initials: SC
authors.lastname: Joseph
authors.forename: K Sateesh
authors.initials: KS
authors.lastname: Reddy
authors.forename: L Srinivasula
authors.initials: LS
authors.lastname: Reddy
authors.forename: P Mahesh
authors.initials: PM
authors.lastname: Kumar
authors.forename: G Rama
authors.initials: GR
authors.lastname: Krishna
authors.forename: C Malla
authors.initials: CM
authors.lastname: Reddy
authors.forename: D
authors.initials: D
authors.lastname: Rambabu
authors.forename: Ravikumar
authors.initials: R
authors.lastname: Kapavarapu
authors.forename: Chandana
authors.initials: C
authors.lastname: Lakshmi
authors.forename: Teja
authors.initials: T
authors.lastname: Meda
authors.forename: K Krishna
authors.initials: KK
authors.lastname: Priya
authors.forename: Kishore V L
authors.initials: KV
authors.lastname: Parsa
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D002384:Catalysis; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism*; D057809:HEK293 Cells; D006801:Humans; D008958:Models, Molecular; D010165:Palladium / Q000737:chemistry*; D058988:Phosphodiesterase 4 Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D058988:Phosphodiesterase 4 Inhibitors; D011758:Pyrroles; D010165:Palladium; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4