title: Wilms' tumor gene 1 expression: an independent acute leukemia prognostic indicator following allogeneic hematopoietic SCT.
abstract: To evaluate the prognostic significance of Wilms' tumor gene 1 (WT1) expression for monitoring minimal residual disease and predicting relapse in patients with acute leukemia (AL) following allogeneic hematopoietic SCT (allo-HSCT), the WT1 expression levels of 138 AL patients were measured using real-time quantitative reverse transcription PCR at designed time points after allo-HSCT. All patients were divided into four groups based on the HSCT outcomes and intervention application. A low level of WT1 expression following HSCT indicated a low risk of relapse, whereas WT1 expression >1.05% was indicative of a higher probability of relapse. Only the advanced stage of disease (hazard ratio (HR)=2.73; 95% confidence interval (CI)=1.337-5.573, P=0.006) and a WT1 expression ≥ 0.60% (HR=4.774; 95% CI=2.410-9.459, P=0.000) were associated with lower disease-free survival. Relapse (HR=0.119; 95% CI=0.056-0.250, P=0.000) and a WT1 expression 0.60% (HR=2.771; 95% CI=1.316-5.834, P=0.007) were associated with lower OS. In conclusion, the WT1 expression level is an independent prognostic factor that can predict clinical outcomes for AL patients after HSCT and provide a guide for suitable interventions.
authors.affiliation: Department of Bone Marrow Transplantation, People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors.forename: X-S
authors.initials: XS
authors.lastname: Zhao
authors.forename: S
authors.initials: S
authors.lastname: Jin
authors.forename: H-H
authors.initials: HH
authors.lastname: Zhu
authors.forename: L-P
authors.initials: LP
authors.lastname: Xu
authors.forename: D-H
authors.initials: DH
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: K-Y
authors.initials: KY
authors.lastname: Liu
authors.forename: X-J
authors.initials: XJ
authors.lastname: Huang
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate; D014184:Transplantation, Homologous; D025721:WT1 Proteins / Q000096:biosynthesis*
chemical_list: D025721:WT1 Proteins