title: Effect of a single intrauterine administration of recombinant bovine interferon-τ on day 7 of the estrous cycle on the luteal phase length and blood profile in dairy cows.
abstract: This study tested the effect of recombinant bovine interferon-tau (rboIFN-τ) on the length of estrous cycle, luteal lifespan and side effects of rboIFN-τ in the cow. A normal estrous cycle in six non-lactating cycling Holstein cows was observed (non-treated cycle), and either 2.0 mg of liposomalized rboIFN-τ (treated cycle) or bovine serum albumin (BSA; placebo cycle) was infused in the uterus on day 7 of the estrous cycle (day 0=day of ovulation). Rectal temperature, heart rate and respiratory rate were recorded and blood samples were collected before and after the treatments. The length of the estrous cycle and corpus luteum lifespan in rboIFN-τ treated cycles were not significantly different from those of the non-treated and placebo cycles. In contrast, the rboIFN-τ treatment caused a transient increase in rectal temperature and a decrease in the number of peripheral lymphocytes and neutrophils after the treatment.
authors.affiliation: Laboratory of Theriogenology, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Ueda 3-18-8, Morioka 020-8550, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Matsunaga
authors.forename: T
authors.initials: T
authors.lastname: Osawa
authors.forename: M
authors.initials: M
authors.lastname: Geshi
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Inumaru
authors.forename: Y
authors.initials: Y
authors.lastname: Yokomizo
authors.forename: Y-I
authors.initials: YI
authors.lastname: Miyake
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002417:Cattle / Q000097:blood / Q000502:physiology; D003338:Corpus Luteum / Q000187:drug effects; D030762:Estrous Cycle / Q000097:blood / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007370:Interferon Type I / Q000008:administration & dosage / Q000494:pharmacology*; D007958:Leukocyte Count / Q000662:veterinary; D008183:Luteal Phase / Q000097:blood / Q000187:drug effects*; D018655:Lymphocyte Count / Q000662:veterinary; D009504:Neutrophils / Q000187:drug effects; D011257:Pregnancy Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D056152:Respiratory Rate / Q000187:drug effects; D013997:Time Factors
chemical_list: D007370:Interferon Type I; D011257:Pregnancy Proteins; D011994:Recombinant Proteins; C020947:interferon tau