title: Associations of complement factor H and smoking with early age-related macular degeneration: the ALIENOR study.
abstract: OBJECTIVE
  To assess the associations of complement factor H (CFH) Y402H polymorphism and smoking with specific features of early AMD (type, location, and area).
  
  
  METHODS
  The ALIENOR study is a population-based study of age-related eye diseases in 963 residents of Bordeaux (France), aged 73 years or more. AMD features were graded from nonmydriatic color retinal photographs. CFH Y402H was genotyped by using DNA extracted from blood. Statistical analyses included 796 subjects with complete data.
  
  
  RESULTS
  CFH CC genotype was strongly associated with late neovascular AMD (OR, 6.0; 95% confidence interval [CI], 1.5-23.5) but not with late atrophic AMD (OR, 0.9; 95% CI, 0.2-4.3). Among early characteristics, it was associated with central soft drusen (within 500 μm of the fovea), whether of intermediate (63-125 μm; OR, 2.7; 95% CI, 1.5-4.8), or large (>125 μm; OR, 5.9; 95% CI, 2.2-15.7) size, but not with pericentral soft drusen (500-3000 μm from the fovea). It was also strongly associated with a large central area of soft drusen (OR, 5.7; 95% CI, 1.7-19.2). Similarly, heavy smoking (>20 pack-years) was strongly associated with central large drusen (OR, 3.9; 95% CI, 1.6-9.6) and a large central area of drusen (OR, 3.5; 95% CI, 1.2-10.0), but not with pericentral soft drusen. By contrast, both CFH CC and smoking tended to be more strongly associated with pericentral pigmentary abnormalities.
  
  
  CONCLUSIONS
  Location of abnormalities, together with type and area, may prove useful for the identification of subjects at high risk for late AMD.
authors.affiliation: INSERM, U897, Bordeaux, France. cecile.delcourt@isped.u-bordeaux2.fr
authors.forename: Cécile
authors.initials: C
authors.lastname: Delcourt
authors.forename: Marie-Noëlle
authors.initials: MN
authors.lastname: Delyfer
authors.forename: Marie-Bénédicte
authors.initials: MB
authors.lastname: Rougier
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Joseph
authors.initials: J
authors.lastname: Colin
authors.forename: Mélanie
authors.initials: M
authors.lastname: Le Goff
authors.forename: Florence
authors.initials: F
authors.lastname: Malet
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lambert
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Korobelnik
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D017242:Complement Factor H / Q000235:genetics; D005260:Female; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D006801:Humans; D008019:Life Style; D008268:Macular Degeneration / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D015594:Optic Disk Drusen / Q000453:epidemiology / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*
chemical_list: C493495:CFH protein, human; D017242:Complement Factor H