title: Anovulatory bleeding in a 12-year-old as presenting sign for rare undifferentiated sarcoma.
abstract: BACKGROUND
  Abnormal uterine bleeding is a common phenomenon in perimenarchal females. Though most cases of abnormal bleeding are due to anovulatory bleeding or bleeding disorders, rare cases are attributable to underlying malignancy.
  
  
  METHODS
  Here we report a 12-year-old female patient who presented with abnormal uterine bleeding three months after menarche. She was ultimately diagnosed with a pelvic sarcoma of unknown primary origin. She was subsequently treated with chemotherapy, whole pelvic radiation, and hysterectomy with bilateral salpingo-oophorectomy.
  
  
  CONCLUSIONS
  Abnormal uterine bleeding unresponsive to conventional temporizing measures should be thoroughly evaluated. Management of pelvic malignancies in the pediatric population requires cooperation amongst specialists from an array of disciplines.
authors.affiliation: Division of Women's Reproductive Healthcare, Department of Obsterics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35249, USA.
authors.forename: Janeen
authors.initials: J
authors.lastname: Arbuckle
authors.forename: Kim
authors.initials: K
authors.lastname: Hoover
mesh_terms: D000858:Anovulation; D002648:Child; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007044:Hysterectomy; D010052:Ovariectomy; D058994:Salpingectomy; D012509:Sarcoma / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000175:diagnosis*; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000628:therapy