title: Association of amino-terminal pro-brain natriuretic peptide with metabolic syndrome.
abstract: OBJECTIVE
  This study evaluated the relationship between individual components in metabolic syndrome (MetS) and amino-terminal pro-brain natriuretic peptide (NT-proBNP).
  
  
  METHODS
  A screening program for MetS in 2008 in Taiwan excluded subjects aged <30 years and pregnant women. Fasting glucose, insulin level, high-sensitivity C-reactive protein (hsCRP), and NT-proBNP were assessed. A propensity-score matching process was used to select subjects with and without MetS comparable in age, gender, body height, and serum creatinine levels. A multiple regression model was used to determine the association between individual components of MetS and NT-proBNP. Finally 270 subjects with MetS and another 270 matched subjects without MetS aged ≥30 years were included.
  
  
  RESULTS
  The subjects with MetS had higher uric acid and hsCRP, but not NT-proBNP. Multiple regression model showed that log (NT-proBNP) was positively associated with systolic blood pressure (β=0.002 per mmHg, p=0.013), but negatively associated with body mass index (β=-0.017 per kg/m(2), p=0.018), triglyceride (β=-0.00048 per mg/dL, p=0.020) and insulin level (β=-0.005 per mU/L, p=0.005). Log (NT-proBNP) was neutral to waist circumference, fasting glucose, high-density lipoprotein cholesterol, and diastolic blood pressure.
  
  
  CONCLUSIONS
  MetS was not associated with serum NT-proBNP concentrations due to the contradictory effects of each component.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Taiwan.
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Li
authors.forename: Fu-Chun
authors.initials: FC
authors.lastname: Chiu
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Chien
authors.forename: Jou-Wei
authors.initials: JW
authors.lastname: Lin
authors.forename: Juey-Jen
authors.initials: JJ
authors.lastname: Hwang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis* / Q000208:ethnology; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012044:Regression Analysis; D013624:Taiwan
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein