title: Negative regulation of NF-κB and its involvement in rheumatoid arthritis.
abstract: The transcription factor NF-κB plays crucial roles in the regulation of inflammation and immune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses. Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis.
authors.affiliation: Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium. geert.vanloo@dmbr.vib-ugent.be
authors.forename: Geert
authors.initials: G
authors.lastname: van Loo
authors.forename: Rudi
authors.initials: R
authors.lastname: Beyaert
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D014158:Transcription, Genetic / Q000276:immunology*
chemical_list: D016328:NF-kappa B