title: [Effect on expression of vascular smooth muscle cell calcium channel in rats exposed in low temperature].
abstract: OBJECTIVE
  To observe the expression of vascular smooth muscle cells calcium channel α1C subunit (LTCCα1C) in rats exposed in low temperature.
  
  
  METHODS
  Cold-induced hypertension was established and blood pressure was measured every two weeks. The mRNA expression of L type calcium channel α1C was determined by RT-PCR.
  
  
  RESULTS
  The blood pressure of the rats exposed to cold environment increased. The blood pressure of experimental groups [(102.8 ± 2.25) mm Hg] began to increase from the first two weeks, compared with the control group [(89.2 ± 3.73) mm Hg], there were significant difference (P < 0.05). The blood pressure of experimental groups were (114.5 ± 4.21), (121.9 ± 3.03) mm Hg respectively at 4, 6 weeks. Compared with the control group, the expression of LTCCα1C mRNA of the cold exposure group increased significantly (P < 0.01). There was a significant correlation between the expression of LTCCα1C mRNA and the blood pressure of the rats (r = 0.86, P < 0.01).
  
  
  CONCLUSIONS
  Repeated cold exposure can establish cold-induced hypertension, and the level of vascular smooth muscle cells LTCCα1C expression increase.
authors.affiliation: Department of Cardiology, Jiangxi Provincial People's Hospital, Nanchang 330006, China.
authors.forename: Dong-mei
authors.initials: DM
authors.lastname: Yang
authors.forename: Shu-hua
authors.initials: SH
authors.lastname: Zhang
authors.forename: Yu-zhi
authors.initials: YZ
authors.lastname: Ge
authors.forename: Yun-xia
authors.initials: YX
authors.lastname: Wang
authors.forename: Yan-feng
authors.initials: YF
authors.lastname: Liu
authors.forename: Zhi-ting
authors.initials: ZT
authors.lastname: Wu
mesh_terms: D000818:Animals; D001794:Blood Pressure; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D003080:Cold Temperature / Q000009:adverse effects; D006973:Hypertension; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C504728:Cacna1c protein, rat; D020746:Calcium Channels, L-Type