title: Imaging brain tumor by dendrimer-based optical/paramagnetic nanoprobe across the blood-brain barrier.
abstract: A multimodal optical/paramagnetic nanoprobe, Den-Angio, was developed and demonstrated a capability to circumvent the blood brain barrier (BBB) and visualize brain tumors with high sensitivity in vivo. Den-Angio holds promise to pre-operatively localize brain tumors and make image-guided tumor resection possible during surgery.
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital affiliated to Fudan University, 180 Fenglin Rd., Shanghai 200032, China.
authors.forename: Huihui
authors.initials: H
authors.lastname: Yan
authors.forename: Jiyao
authors.initials: J
authors.lastname: Wang
authors.forename: Peiwei
authors.initials: P
authors.lastname: Yi
authors.forename: Hao
authors.initials: H
authors.lastname: Lei
authors.forename: Changyou
authors.initials: C
authors.lastname: Zhan
authors.forename: Cao
authors.initials: C
authors.lastname: Xie
authors.forename: Linglin
authors.initials: L
authors.lastname: Feng
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhu
authors.forename: Weiyue
authors.initials: W
authors.lastname: Lu
authors.forename: Cong
authors.initials: C
authors.lastname: Li
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000737:chemistry*; D006801:Humans; D008280:Magnetics; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D015335:Molecular Probes / Q000737:chemistry / Q000378:metabolism*; D055620:Optical Phenomena
chemical_list: D050091:Dendrimers; D015335:Molecular Probes