title: Airway pathogens during the first year after lung transplantation: a single-center experience.
abstract: After lung transplantation, a high level of immunosuppression is needed to prevent rejection. This demand renders recipients more sensitive to infections. As pulmonary infections are a major clinical problem during the first postoperative year after lung transplantation, preventive treatment and regular surveillance examinations are needed for immediate, adequate therapy. We describe the airway pathogens registered during the first posttransplantation year among our 12 lung transplant recipients since December 2008. Samples were obtained for microbiologic analysis from the upper and lower respiratory tracts and from serum as part of routine care. During the first year after transplantation the most frequent pathogens were fungi (Candida albicans 82%; Aspergillus 50%), Pneumocystis (8%), gram-negative bacteria (Pseudomonas spp 60%; Klebsiella 25%, Acinetobacter 17%; Escherichia Coli 17%; and Enterococcus faecalis 25%), and Staphylococcus aureus (50%, including methicillin-resistant strains 25%). This pathogen spectrum in the first postoperative year after lung transplantation was similar to other centers. Colonization with Pseudomonas or fungi presented early and was prevalent among our patients.
authors.affiliation: Department of Pulmonology, Semmelweis University, Budapest, Hungary. tskovacs@freemail.hu
authors.forename: Z
authors.initials: Z
authors.lastname: Kovats
authors.forename: Z
authors.initials: Z
authors.lastname: Sütto
authors.forename: G
authors.initials: G
authors.lastname: Muraközy
authors.forename: A
authors.initials: A
authors.lastname: Bohacs
authors.forename: K
authors.initials: K
authors.lastname: Czebe
authors.forename: G
authors.initials: G
authors.lastname: Lang
authors.forename: F
authors.initials: F
authors.lastname: Renyi-Vamos
authors.forename: W
authors.initials: W
authors.lastname: Klepetko
authors.forename: V
authors.initials: V
authors.lastname: Müller
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D001999:Bronchoscopy; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008168:Lung / Q000382:microbiology / Q000601:surgery* / Q000821:virology; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000821:virology*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D007166:Immunosuppressive Agents