title: The evolution of understanding inhalant allergy.
abstract: This article summarizes the developments that led to the current approach to immunotherapy. These developments were characterized in the early years by empirically derived successive approximations to arrive at effective injection regimens, in the middle years by a sorting through of the wide variations in practice with placebo-controlled clinical trials, and more recently by a closer association of clinical and laboratory measures to better define evidence-based practices. The pace of investigation along with the scientific quality continues to increase.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA. John.Osguthorpe@va.gov
authors.forename: J David
authors.initials: JD
authors.lastname: Osguthorpe
mesh_terms: D049671:History, 18th Century; D049672:History, 19th Century; D049690:History, Ancient; D006801:Humans; D007159:Immunologic Tests / Q000266:history*; D007167:Immunotherapy / Q000266:history*; D012221:Rhinitis, Allergic, Perennial / Q000266:history*; D006255:Rhinitis, Allergic, Seasonal / Q000266:history*