title: Unexpected phosphodiesterase activity at low pH of a dinuclear copper-β-cyclodextrin complex.
abstract: A surprisingly low pK(a) (4.3) for a Cu(II) bridging water was found in the presented complex, Cu(2)L, resulting in 3 orders of magnitude higher phosphodiesterase activity on BNPP than Zn(2)L at typical lysosomal pH (~5.0).
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhao
authors.forename: Han-Lu
authors.initials: HL
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Cunyuan
authors.initials: C
authors.lastname: Zhao
authors.forename: Liang-Nian
authors.initials: LN
authors.lastname: Ji
authors.forename: Zong-Wan
authors.initials: ZW
authors.lastname: Mao
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D047392:beta-Cyclodextrins; D003300:Copper; D010727:Phosphoric Diester Hydrolases