title: Spinal multifocal amyloidosis derived from wild-type transthyretin.
abstract: Abstract Spinal amyloidosis can occur as a part of systemic amyloidosis or as localized amyloidomas. However, the exact pathogenesis of the spinal amyloidosis remains to be fully understood. Transthyretin (TTR) is an amyloidogenic protein causing two kinds of amyloid diseases. One is senile systemic amyloidosis (SSA), which is caused by wild-type (WT) TTR and primarily affects cardiac functions. The other type is familial amyloidosis, which is mainly induced by mutated TTR. We report here the first case of multifocal spinal TTR amyloidosis derived from WT TTR with radiculomyelopathy and destructive spondylosis. The data and clinical manifestations suggest that the patient may develop SSA. Clinical manifestations of TTR-related amyloidosis may vary more than we previously thought. In spinal amyloidosis, WT TTR is one of the candidate precursor proteins for the disease.
authors.affiliation: Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan.
authors.forename: Takanao
authors.initials: T
authors.lastname: Sueyoshi
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Ueda
authors.forename: Akira
authors.initials: A
authors.lastname: Sei
authors.forename: Yohei
authors.initials: Y
authors.lastname: Misumi
authors.forename: Toshinori
authors.initials: T
authors.lastname: Oshima
authors.forename: Taro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Konen
authors.initials: K
authors.lastname: Obayashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Shinriki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Jono
authors.forename: Makoto
authors.initials: M
authors.lastname: Shono
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ando
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizuta
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D015153:Blotting, Western; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011228:Prealbumin / Q000378:metabolism*; D011843:Radiculopathy / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D055009:Spondylosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D011228:Prealbumin