title: [Application of thrombolytic therapy of ischemic stroke in the Russian Federation].
abstract: To study the efficacy and safety of thrombolytic therapy (TLT) with the recombinant tissue plasminogen activator (rt-PA) in stroke, we treated 691 patients in 48 clinical units using systemic or selective TLT. Safety and high efficacy of TLT was shown: the three-months fatality rate was 18.2%, the symptomatic hemorrhage transformation rate related to clinical worsening was 6.1%. The good functional recovery (scores 0 or 1 on the modified Rankin scale) was observed in 48.6% of patients.
authors.forename: V I
authors.initials: VI
authors.lastname: Skvortsova
authors.forename: N A
authors.initials: NA
authors.lastname: Shamalov
authors.forename: K V
authors.initials: KV
authors.lastname: Anisimov
authors.forename: G R
authors.initials: GR
authors.lastname: Ramazanov
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use*; D012426:Russia / Q000453:epidemiology; D020521:Stroke / Q000188:drug therapy* / Q000401:mortality; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator