title: [Abnormal increase in CD8(low) T lymphocyte in patients with occupational chronic lead poisoning].
abstract: OBJECTIVE
  To analyze the changes in CD8(low) T lymphocyte subsets in patients with occupational chronic lead poisoning.
  
  
  METHODS
  Flow cytometric analysis was used to count the numbers of CD8+ cells. 23 patients with occupational chronic lead poisoning and 20 controls were examined.
  
  
  RESULTS
  Compared with control group (8.21% ± 3.02%), the CD8(low) T lymphocyte (12.98% ± 5.62%) were significantly increased in patients with occupational chronic lead poisoning.
  
  
  CONCLUSIONS
  Although the ratio of CD+ T lymphocyte is normal, the CD8 level is significantly decreased. The increase of CD8(low) T lymphocyte may be an important phenomenon of immuno-injury induced by lead. CD8(low) T lymphocyte could be an new direction for research of lead immuno-toxicity.
authors.affiliation: Department of Internal Medicine, Guangzhou Municipal Twelfth People's Hospital, Guangzhou 510620, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.forename: Jia-yu
authors.initials: JY
authors.lastname: Chen
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Liu
authors.forename: Ling-zhen
authors.initials: LZ
authors.lastname: Chen
authors.forename: Jin-min
authors.initials: JM
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhan
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Yang-qiu
authors.initials: YQ
authors.lastname: Li
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007855:Lead Poisoning / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D009784:Occupational Diseases / Q000276:immunology*; D055815:Young Adult