title: "Click" synthesis of fatty acid derivatives as fast-degrading polyanhydride precursors.
abstract: Fast-degrading linear and branched polyanhydrides are obtained by melt-condensation of novel di- and tri-carboxylic acid monomers based on oleic and undecylenic acid synthesized using photoinitiated thiol-ene click chemistry. (1)H NMR spectroscopy, size exclusion chromatography, differential scanning calorimetry, thermogravimetric analysis, and FT-IR spectroscopy have been used to fully characterize these polymers. The hydrolytic degradation of these polymers was studied by means of weight loss, anhydride bond loss, and changes in molecular weight, showing fast degrading properties. Drug release studies from the synthesized polyanhydrides have also been conducted, using rhodamine B as a hydrophobic model drug, to evaluate the potential of these polymers in biomedical applications.
authors.affiliation: Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, C/ Marcel.lí Domingo s/n, 43007 Tarragona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Lluch
authors.forename: Gerard
authors.initials: G
authors.lastname: Lligadas
authors.forename: Joan C
authors.initials: JC
authors.lastname: Ronda
authors.forename: Marina
authors.initials: M
authors.lastname: Galià
authors.forename: Virginia
authors.initials: V
authors.lastname: Cadiz
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D057930:Click Chemistry; D004337:Drug Carriers; D065546:Drug Liberation; D006868:Hydrolysis; D008027:Light; D008970:Molecular Weight; D009829:Oleic Acids / Q000138:chemical synthesis*; D055668:Photochemical Processes; D049388:Polyanhydrides / Q000138:chemical synthesis*; D012235:Rhodamines / Q000737:chemistry; D014476:Undecylenic Acids / Q000138:chemical synthesis*
chemical_list: D002264:Carboxylic Acids; D004337:Drug Carriers; D009829:Oleic Acids; D049388:Polyanhydrides; D012235:Rhodamines; D014476:Undecylenic Acids; C029773:rhodamine B