title: Association of insulin resistance with arterial stiffness in nondiabetic peritoneal dialysis patients.
abstract: BACKGROUND
  Insulin resistance is a risk factor for cardiovascular morbidity and mortality in the general and end-stage renal disease populations. In this study, we investigated the association between insulin resistance and arterial stiffness in nondiabetic peritoneal dialysis (PD) patients.
  
  
  METHODS
  Fifty-three patients were enrolled. Patients were divided into 2 groups as homeostasis model assessment of insulin resistance (HOMA-IR) ≤ 2.97 (low) and >2.97 (high). Carotid-femoral pulse wave velocity (c-f PWV) analysis and intima-media thickness of the carotid artery were measured.
  
  
  RESULTS
  Mean age was 46 ± 12 years and HOMA-IR was 2.97 ± 1.77 (0.77-8.88). Mean c-f PWV was 7.6 ± 1.7 m/s. HOMA-IR was positively correlated with age, body mass index, and c-f PWV and negatively with serum HDL cholesterol and parathormone. In linear regression analysis, age and mean arterial pressure were predictors for c-f PWV. When patients were divided into 2 groups according to median age as ≤ 49 and >50, mean arterial pressure, male gender, and age were predictors for c-f PWV in patients aged ≤ 49, whereas HOMA-IR was the only predictor for c-f PWV in patients aged >50 years.
  
  
  CONCLUSIONS
  Insulin resistance is an independent risk factor for arterial stiffness in PD patients older than 50 years. IR is not associated with carotid intima-media thickness.
authors.affiliation: Division of Nephrology, Ege University School of Medicine, 35100 Bornova, Izmir, Turkey. etatar@hotmail.com
authors.forename: Erhan
authors.initials: E
authors.lastname: Tatar
authors.forename: Meltem Sezis
authors.initials: MS
authors.lastname: Demirci
authors.forename: Fatih
authors.initials: F
authors.lastname: Kircelli
authors.forename: Ozkan
authors.initials: O
authors.lastname: Gungor
authors.forename: Mehmet Nuri
authors.initials: MN
authors.lastname: Turan
authors.forename: Ebru
authors.initials: E
authors.lastname: Sevinc Ok
authors.forename: Gulay
authors.initials: G
authors.lastname: Asci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozkahya
authors.forename: Ercan
authors.initials: E
authors.lastname: Ok
mesh_terms: D000328:Adult; D000367:Age Factors; D001783:Blood Flow Velocity; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011673:Pulsatile Flow; D012307:Risk Factors; D012737:Sex Factors; D059289:Vascular Stiffness
chemical_list: D008076:Cholesterol, HDL