title: Cytomegalovirus seroprevalence among solid organ donors in Hungary: correlations with age, gender, and blood group.
abstract: BACKGROUND
  Cytomegalovirus (CMV) is endemic throughout the world, affecting most of the population, but the seroprevalence of CMV is known to vary among countries. CMV causes a mild infection in persons with intact immunity; however, CMV infection in organ transplantation is associated with significant morbidity and mortality. The present retrospective study was designed to evaluate the age-, gender-, and blood group-adjusted CMV seroprevalence among solid organ donors, representing fairly the overall Hungarian population (according to Hungarian Central Statistic Institute). This information is important for calculating risk-factors for CMV-seronegative recipients. No nationwide estimates of CMV seroprevalence in Hungary (as a representative of Eastern Middle Europe) have been published yet.
  
  
  METHODS
  We investigated 2070 organ donors for CMV seroprevalence by measuring the CMV-specific immunoglobulin G. The donors were divided into 3 age groups (2-20, 21-50, and 51-70 years old). A study was also conducted on a fourth group consisting of 200 residents from an old age home. CMV seroprevalence differences were searched according to age-, gender- and blood-group distribution.
  
  
  RESULTS
  The CMV seroprevalence of organ donors is 85% and of all investigated persons is 86%. The age-specific prevalence increases, starting from 72% in the first group to 99% in the fourth group. Seroprevalence of females was found to be significantly higher than of males (P=.0001).
  
  
  CONCLUSIONS
  We have shown that the overall CMV seroprevalence in the Hungarian population is moderately high at 86%. The opportunity for CMV-seronegative recipients to get a graft from a seronegative donor is statistically only 2%. The seroprevalence of the youngest age group is 72% and so it can be concluded that the Hungarian population acquires the infection mainly in childhood or in the early adulthood. Female gender is a risk factor for CMV infection. This fact must be taken into consideration during the planning of patients' follow-up, prophylaxis, and therapy.
authors.affiliation: Transplantation and Surgical Clinic, Semmelweis University, Budapest, Hungary. vmarisa1@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Varga
authors.forename: D
authors.initials: D
authors.lastname: Görög
authors.forename: D
authors.initials: D
authors.lastname: Kári
authors.forename: E
authors.initials: E
authors.lastname: Környei
authors.forename: É
authors.initials: É
authors.lastname: Kis
authors.forename: H J
authors.initials: HJ
authors.lastname: Túryné
authors.forename: I
authors.initials: I
authors.lastname: Jankovics
authors.forename: A
authors.initials: A
authors.lastname: Péter
authors.forename: É
authors.initials: É
authors.lastname: Toronyi
authors.forename: E
authors.initials: E
authors.lastname: Sárváry
authors.forename: J
authors.initials: J
authors.lastname: Fazakas
authors.forename: Gy
authors.initials: G
authors.lastname: Reusz
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D001789:Blood Group Antigens / Q000097:blood*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D012737:Sex Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D001789:Blood Group Antigens; D007074:Immunoglobulin G