title: PPAR-α transcriptional activity is required to combat doxorubicin-induced podocyte injury in mice.
abstract: Immunosuppressants and inhibitors of the renin angiotensin system are major reagents to treat nephrotic syndrome but their clinical effects are not necessarily satisfactory. Injection of doxorubicin in several strains of mice causes nephrotic syndrome-like disorder. Zhou et al. report that PPAR-α expression is downregulated in murine doxorubicin nephropathy and a PPAR-α agonist, fenofibrate, partially ameliorates the disorder induced likely through stabilization of nephrin expression and suppression of apoptosis in podocytes, providing a new preventive strategy.
authors.affiliation: Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan. keyem@kuhp.kyoto-u.ac.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Mori
authors.forename: Masashi
authors.initials: M
authors.lastname: Mukoyama
authors.forename: Kazuwa
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D019610:Cytoprotection; D004195:Disease Models, Animal; D004317:Doxorubicin; D011345:Fenofibrate / Q000494:pharmacology; D007674:Kidney Diseases / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D007678:Kidney Glomerulus / Q000378:metabolism* / Q000473:pathology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D047493:PPAR alpha / Q000819:agonists / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D050199:Podocytes / Q000378:metabolism / Q000473:pathology; D011507:Proteinuria / Q000378:metabolism / Q000517:prevention & control; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D013997:Time Factors; D014158:Transcription, Genetic
chemical_list: D008565:Membrane Proteins; D047493:PPAR alpha; D019253:Proto-Oncogene Proteins c-bcl-2; C113267:nephrin; D004317:Doxorubicin; C505409:Casp3 protein, mouse; D053148:Caspase 3; D011345:Fenofibrate