title: Clinical and genetic correlates of severity in schizophrenia in India: an ordinal logistic regression approach.
abstract: Genetic association studies of schizophrenia typically utilize diagnostic status as the trait of interest. Among Indian schizophrenia (SZ) participants, we evaluated genetic associations (selected single nucleotide polymorphisms (SNPs) associated with SZ) with selected indices of severity and symptom pattern. Ordinal logistic regression enabled us to analyze variables with multiple categories as outcome variables, while incorporating key demographic variables; this form of analysis may be useful in future genetic association studies. No significant associations were detected following corrections for multiple comparisons.
authors.affiliation: Dr RML Hospital, New Delhi, India.
authors.forename: Pramod
authors.initials: P
authors.lastname: Thomas
authors.forename: Abha
authors.initials: A
authors.lastname: Chandra
authors.forename: Triptish
authors.initials: T
authors.lastname: Bhatia
authors.forename: N N
authors.initials: NN
authors.lastname: Mishra
authors.forename: Vikash Ranjan
authors.initials: VR
authors.lastname: Sharma
authors.forename: Deepak
authors.initials: D
authors.lastname: Gauba
authors.forename: Joel
authors.initials: J
authors.lastname: Wood
authors.forename: Kodavali
authors.initials: K
authors.lastname: Chowdari
authors.forename: Prachi
authors.initials: P
authors.lastname: Semwal
authors.forename: B K
authors.initials: BK
authors.lastname: Thelma
authors.forename: Vishwajit L
authors.initials: VL
authors.lastname: Nimgaonkar
authors.forename: Smita N
authors.initials: SN
authors.lastname: Deshpande
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007194:India / Q000453:epidemiology / Q000208:ethnology; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D055815:Young Adult