title: Cognitive functioning in recent onset psychosis.
abstract: The purpose of the study was to compare the cognitive functioning of persons with a recent onset of psychosis with schizophrenia-spectrum disorders and bipolar disorder and nonpsychiatric controls. A total of 56 persons with a schizophrenia-spectrum disorder and 60 with bipolar disorder, all with a recent onset psychosis, and 312 nonpsychiatric controls were evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Wisconsin Card Sorting Test (WCST). Comparison of the three groups through analysis of covariance indicated a significant difference among the groups for all of the cognitive variables. Pairwise contrasts of the two recent onset groups showed a significant difference favoring the bipolar disorder group on RBANS Language (p = 0.020) and Total (p = 0.050) and a marginally significant difference on RBANS Immediate Memory (p = 0.053) but not on the other RBANS variables or on the WCST. Cognitive performance is broadly impaired in recent onset psychosis, with a cognitive advantage to bipolar disorder patients compared with schizophrenia-spectrum patients.
authors.affiliation: Sheppard Pratt, Baltimore, MD 21204, USA. fdickerson@sheppardpratt.org
authors.forename: Faith
authors.initials: F
authors.lastname: Dickerson
authors.forename: Cassie
authors.initials: C
authors.lastname: Stallings
authors.forename: Crystal
authors.initials: C
authors.lastname: Vaughan
authors.forename: Andrea
authors.initials: A
authors.lastname: Origoni
authors.forename: Sunil
authors.initials: S
authors.lastname: Khushalani
authors.forename: Dwight
authors.initials: D
authors.lastname: Dickinson
authors.forename: Deborah
authors.initials: D
authors.lastname: Medoff
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011618:Psychotic Disorders / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D013997:Time Factors; D055815:Young Adult