title: Vitamin D receptor activation: clinical outcomes.
abstract: Vitamin D has been recognized for years as a key player in the control of bone metabolism through the regulation of calcium and phosphate homeostasis. Vitamin D deficiency appears to be common in the general population as a result of decreased dietary intake, diminished absorption, or limited exposure to sunlight. Vitamin D deficiency results in increased circulating levels of parathyroid hormone, which has several disadvantageous effects on bone metabolism. The intake of ordinary doses of vitamin D supplements appears to be associated with a decrease in total mortality rates. In the chronic kidney disease (CKD) population, vitamin D receptor (VDR) activation deficiency is even more severe than in a non-CKD population, with a 25-(OH) vitamin D level being an independent predictor of all-cause mortality. Similarly to nonrenal populations, the corrections of vitamin D deficiency/treatment with vitamin D is associated with better survival. Selective VDR activators appears to be better than calcitriol in terms of survival or adverse effects.
authors.forename: Adrian
authors.initials: A
authors.lastname: Covic
authors.forename: Mugurel
authors.initials: M
authors.lastname: Apetrii
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality; D002908:Chronic Disease; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000188:drug therapy*; D018167:Receptors, Calcitriol / Q000502:physiology*; D006435:Renal Dialysis / Q000401:mortality; D014807:Vitamin D / Q000008:administration & dosage; D014808:Vitamin D Deficiency / Q000150:complications
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D