title: A double-blind, placebo-controlled, randomised trial of active manuka honey and standard oral care for radiation-induced oral mucositis.
abstract: Our aim was to investigate the effect of active manuka honey on radiation-induced mucositis. A total of 131 patients diagnosed with head and neck cancer who were having radiotherapy to the oral cavity or oropharyngeal area were recruited into the study, and were randomly allocated to take either manuka honey or placebo (golden syrup) 20 ml 4 times daily for 6 weeks. Mucositis was assessed according to the Radiation Therapy Oncology Group (RTOG) scale at baseline, weekly during radiotherapy, and twice weekly thereafter until the mucositis resolved. The patient's weight was recorded at the same time as the mucositis was assessed. Throat swabs to identify bacterial or fungal infections were taken at baseline, and during and after radiotherapy. There was no significant difference between honey and golden syrup in their effects on mucositis. Active manuka honey did not improve mucositis, but both the honey and the syrup seemed to be associated with a reduction in bacterial infections. Compliance was a problem after the onset of mucositis, which may have affected the findings.
authors.affiliation: School of Nursing, Social Work and Midwifery, University of Manchester, Room 5.304 5th Floor, Jean McFarlane Building, University Place, Oxford Road, Manchester M13 9PL, United Kingdom. Joy.Bardy@manchester.ac.uk
authors.forename: Joy
authors.initials: J
authors.lastname: Bardy
authors.forename: Alex
authors.initials: A
authors.lastname: Molassiotis
authors.forename: W David
authors.initials: WD
authors.lastname: Ryder
authors.forename: Kathleen
authors.initials: K
authors.lastname: Mais
authors.forename: Andrew
authors.initials: A
authors.lastname: Sykes
authors.forename: Beng
authors.initials: B
authors.lastname: Yap
authors.forename: Lip
authors.initials: L
authors.lastname: Lee
authors.forename: Ed
authors.initials: E
authors.lastname: Kaczmarski
authors.forename: Nicholas
authors.initials: N
authors.lastname: Slevin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use; D001424:Bacterial Infections / Q000517:prevention & control; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D017024:Chemotherapy, Adjuvant; D004311:Double-Blind Method; D004750:Enteral Nutrition; D005260:Female; D006722:Honey; D006801:Humans; D031649:Leptospermum; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000528:radiation effects; D009062:Mouth Neoplasms / Q000532:radiotherapy; D009181:Mycoses / Q000517:prevention & control; D009894:Opportunistic Infections / Q000382:microbiology / Q000517:prevention & control; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy; D009960:Oropharynx / Q000528:radiation effects; D010349:Patient Compliance; D010608:Pharyngeal Diseases / Q000382:microbiology / Q000517:prevention & control; D010919:Placebos; D011832:Radiation Injuries / Q000209:etiology / Q000628:therapy*; D013280:Stomatitis / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D000700:Analgesics; D010919:Placebos