title: Automated discrimination of brain pathological state attending to complex structural brain network properties: the shiverer mutant mouse case.
abstract: Neuroimaging classification procedures between normal and pathological subjects are sparse and highly dependent of an expert's clinical criterion. Here, we aimed to investigate whether possible brain structural network differences in the shiverer mouse mutant, a relevant animal model of myelin related diseases, can reflect intrinsic individual brain properties that allow the automatic discrimination between the shiverer and normal subjects. Common structural networks properties between shiverer (C3Fe.SWV Mbp(shi)/Mbp(shi), n = 6) and background control (C3HeB.FeJ, n = 6) mice are estimated and compared by means of three diffusion weighted MRI (DW-MRI) fiber tractography algorithms and a graph framework. Firstly, we found that brain networks of control group are significantly more clustered, modularized, efficient and optimized than those of the shiverer group, which presented significantly increased characteristic path length. These results are in line with previous structural/functional complex brain networks analysis that have revealed topologic differences and brain network randomization associated to specific states of human brain pathology. In addition, by means of network measures spatial representations and discrimination analysis, we show that it is possible to classify with high accuracy to which group each subject belongs, providing also a probability value of being a normal or shiverer subject as an individual anatomical classifier. The obtained correct predictions (e.g., around 91.6-100%) and clear spatial subdivisions between control and shiverer mice, suggest that there might exist specific network subspaces corresponding to specific brain disorders, supporting also the point of view that complex brain network analyses constitutes promising tools in the future creation of interpretable imaging biomarkers.
authors.affiliation: Neuroimaging Department, Cuban Neuroscience Center, La Habana, Cuba. iturria.medina@gmail.com
authors.forename: Yasser
authors.initials: Y
authors.lastname: Iturria-Medina
authors.forename: Alejandro
authors.initials: A
authors.lastname: Pérez Fernández
authors.forename: Pedro
authors.initials: P
authors.lastname: Valdés Hernández
authors.forename: Lorna
authors.initials: L
authors.lastname: García Pentón
authors.forename: Erick J
authors.initials: EJ
authors.lastname: Canales-Rodríguez
authors.forename: Lester
authors.initials: L
authors.lastname: Melie-Garcia
authors.forename: Agustin
authors.initials: A
authors.lastname: Lage Castellanos
authors.forename: Marlis
authors.initials: M
authors.lastname: Ontivero Ortega
mesh_terms: D000818:Animals; D001331:Automation; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D016000:Cluster Analysis; D038524:Diffusion Magnetic Resonance Imaging; D051379:Mice; D008818:Mice, Neurologic Mutants; D009415:Nerve Net / Q000503:physiopathology*; D012768:Shivering / Q000502:physiology*