title: Mediterranean diet mediates the adverse effect of depressive symptomatology on short-term outcome in elderly survivors from an acute coronary event.
abstract: Aims. We evaluated the interaction effect between depressive symptoms and dietary habits on 30-day development of cardiovascular disease (CVD) (death or rehospitalization) in elderly, acute coronary syndrome (ACS) survivors. Methods. During 2006-2008, we recorded 277 nonfatal, consecutive ACS admissions (75 ± 6 years, 70% males, 70% had diagnosis of myocardial infarction) with complete 30-day follow-up. Assessment of recent depressive symptoms was based on the CES-D scale. Among sociodemographic, bioclinical, lifestyle characteristics, the MedDietScore that assesses the inherent characteristics of the Mediterranean diet was applied. Results. 22% of the ACS pts developed a CVD event during the first 30 days (14.8% rehospitalization and 9.4% death). Patients in the upper tertile of the CES-D scale (i.e., >18) had higher incidence of CVD events as compared with those in the lowest tertile (21% versus 8%, P = .01). Multiple logistic regression analysis revealed that 1-unit increase in CES-D was associated with 4% higher odds (95% CI 1.008-1.076, P = .01) of CVD events; however, when MedDietScore was entered in the model, CES-D lost its significance (P = .20). Conclusion. Short-term depressive symptoms are related to a worsen 30-day prognosis of ACS patients; however, this relationship was mediated by Mediterranean diet adherence.
authors.affiliation: First Cardiology Clinic, School of Medicine, University of Athens, 46 Paleon Polemiston Street, 166 74 Glyfada, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Chrysohoou
authors.forename: Catherine
authors.initials: C
authors.lastname: Liontou
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Aggelopoulos
authors.forename: Christina-Maria
authors.initials: CM
authors.lastname: Kastorini
authors.forename: Demosthenes
authors.initials: D
authors.lastname: Panagiotakos
authors.forename: Athanasios
authors.initials: A
authors.lastname: Aggelis
authors.forename: Elefterios
authors.initials: E
authors.lastname: Tsiamis
authors.forename: Manolis
authors.initials: M
authors.lastname: Vavouranakis
authors.forename: Christos
authors.initials: C
authors.lastname: Pitsavos
authors.forename: Dimitris
authors.initials: D
authors.lastname: Tousoulis
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis