title: Acidophilic nuclear inclusions are specific for florid ductal hyperplasia among proliferative breast lesions.
abstract: BACKGROUND
  Recently we have observed distinctive acidophilic intranuclear inclusions in cases of usual intraductal hyperplasia of the breast. Similar inclusions were described almost 20 years ago in cases of mammary hyperplasia. These correlated ultrastructurally with so-called helioid inclusions. However, there since has been little discussion of these inclusions in the literature.
  
  
  OBJECTIVE
  To examine the incidence and specificity of these inclusions in proliferative lesions of the breast.
  
  
  METHODS
  Forty cases of usual intraductal hyperplasia, 15 cases of atypical ductal hyperplasia, and 34 cases of low-grade ductal carcinoma in situ were examined for the presence of acidophilic intranuclear inclusions.
  
  
  RESULTS
  Acidophilic intranuclear inclusions were present in 50% of cases of usual intraductal hyperplasia (20 of 40) but were not identified in any cases of atypical ductal hyperplasia (0 of 15) or low-grade ductal carcinoma in situ (0 of 34).
  
  
  CONCLUSIONS
  Acidophilic intranuclear inclusions appear to be a common, specific feature found in usual intraductal hyperplasia and may be helpful in distinguishing it from atypical ductal hyperplasia and low-grade ductal carcinoma in situ in some cases. Elucidating the nature of these inclusions may provide insight into the pathogenesis of usual intraductal hyperplasia.
authors.affiliation: Department of Pathology, Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Lauer
authors.forename: Gabriela
authors.initials: G
authors.lastname: Oprea-Ilies
authors.forename: Cynthia
authors.initials: C
authors.lastname: Cohen
authors.forename: Volkan
authors.initials: V
authors.lastname: Adsay
authors.forename: Amy L
authors.initials: AL
authors.lastname: Adams
mesh_terms: D016477:Artifacts; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D045586:Intranuclear Inclusion Bodies / Q000648:ultrastructure*