title: Pregabalin-induced hepatotoxicity.
abstract: OBJECTIVE
  To report a case of acute elevation of hepatic enzyme levels as a probable adverse reaction associated with pregabalin.
  
  
  METHODS
  A 59-year-old man with a history of mantle cell lymphoma developed neuropathic pain and was treated with pregabalin 25 mg daily. Fourteen days after beginning pregabalin therapy, he developed left ankle edema and elevation of liver enzyme levels. Peak values were aspartate transaminase 907 U/L, alanine transaminase 1582 U/L, and γ-glutamyltransferase 510 U/L. Pregabalin was discontinued and hepatic enzyme levels returned gradually (over 4 months) to baseline levels.
  
  
  CONCLUSIONS
  Many medications are commonly associated with liver injury; few cases of pregabalin-associated hepatotoxicity have been documented. A MEDLINE search (1966-November 2010) revealed 2 reports of acute liver injury with the initiation of pregabalin. In our patient, with hemosiderosis after hematopoietic cell transplantation, pregabalin worsened the underlying liver injury. The low pregabalin dosage and the short time to elevation of liver enzyme levels suggest an idiosyncratic reaction. According to the Naranjo probability scale and the Council for International Organizations of Medical Sciences probability scale, this reaction was probably due to pregabalin.
  
  
  CONCLUSIONS
  Prescribers should be alert to the possibility of idiosyncratic hepatotoxicity associated with pregabalin use.
authors.affiliation: Pharmacy Department, Hospital Clínico Universitario de Valencia, Valencia, Spain. juanmoll@alumni.uv.es
authors.forename: Juan Moll
authors.initials: JM
authors.lastname: Sendra
authors.forename: Teresa Torrecilla
authors.initials: TT
authors.lastname: Junyent
authors.forename: Maria José Remigia
authors.initials: MJ
authors.lastname: Pellicer
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006486:Hemosiderosis / Q000503:physiopathology; D006801:Humans; D008111:Liver Function Tests; D020522:Lymphoma, Mantle-Cell / Q000150:complications; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy / Q000209:etiology; D000069583:Pregabalin; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid