title: Beneficial effects of dietary fish-oil-derived monounsaturated fatty acids on metabolic syndrome risk factors and insulin resistance in mice.
abstract: The aim of this study was to elucidate the effect of fish-oil-derived monounsaturated fatty acids (MUFAs) containing large amounts of C20:1 and C22:1 isomers on metabolic disorders in mice. Male C57BL/6J mice were fed a 32% lard diet (control) or a 27% lard plus 5% saury-oil-derived MUFA diet for 6 weeks. Dietary MUFA improved insulin resistance and alleviated metabolic syndrome risk factors by reducing blood glucose and lipids. These favorable changes may be attributed to an improved adipocytokine profile. MUFA ingestion resulted in favorable changes in mRNA expression of genes involved in glucose/lipid metabolism (SCD-1, CPT1a, UCPs, and CS) as well as inflammation (MAC1, MMP3, and SAA3) and alterations in fatty acid composition. Our data suggest that marine MUFA improved glucose/lipid homeostasis and hindered the development of metabolic syndrome in obese mice.
authors.affiliation: Central Research Laboratory, Tokyo Innovation Center, Nippon Suisan Kaisha, Ltd., Tokyo 192-0991, Japan. yangzh@nissui.co.jp
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Yang
authors.forename: Hiroko
authors.initials: H
authors.lastname: Miyahara
authors.forename: Tetsu
authors.initials: T
authors.lastname: Mori
authors.forename: Nobushige
authors.initials: N
authors.lastname: Doisaki
authors.forename: Akimasa
authors.initials: A
authors.lastname: Hatanaka
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004041:Dietary Fats / Q000008:administration & dosage; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005395:Fish Oils / Q000737:chemistry*; D007333:Insulin Resistance; D008050:Lipid A / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000150:complications
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D005395:Fish Oils; D008050:Lipid A; C029310:lard