title: How do I begin? Sensing extracellular stress to maintain yeast cell wall integrity.
abstract: The cell wall integrity (CWI) signalling pathway is necessary to remodel the yeast cell wall during normal morphogenesis and in response to cell surface stress. In the Baker's yeast Saccharomyces cerevisiae, a set of five membrane-spanning sensors, namely Wsc1, Wsc2, Wsc3, Mid2 and Mtl1, detect perturbations in the cell wall and/or the plasma membrane and activate a downstream signal transduction pathway with a central MAP kinase module. As a consequence, the expression of genes whose products are involved in cell wall structure and remodelling is induced. This review summarises our recent results on sensor structure and function, as well as the advances made regarding sensor mechanics.
authors.affiliation: University of Osnabrück, Faculty of Biology and Chemistry, Department of Genetics, Barbarastrasse 11, 49076 Osnabrück, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Jendretzki
authors.forename: Janina
authors.initials: J
authors.lastname: Wittland
authors.forename: Sabrina
authors.initials: S
authors.lastname: Wilk
authors.forename: Andrea
authors.initials: A
authors.lastname: Straede
authors.forename: Jürgen J
authors.initials: JJ
authors.lastname: Heinisch
mesh_terms: D002473:Cell Wall / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D029701:Saccharomyces cerevisiae Proteins