title: [Systematic analysis of molecular mechanisms of action of omega-3 polyunsaturated fatty acids on arrhythmia].
abstract: Safe pharmacotherapy and prevention of arrhythmia is an urgent problem of modern cardiology. Essential micronutrients such as omega-3 polyunsaturated fatty acids (-3 PUF-) significantly contribute to the metabolic processes in cardiomyocytes and cardiac conduction system. This article presents a systematic analysis of anti-arrhythmic effects of omega-3 PUFA and of standardized ethyl esters of omega-3 PUFA. The currently available data indicate two fundamentally different molecular mechanisms of anti-arrhythmic effects: "slow" and "fast" types. Formulation of fundamental prospects of bioinformatic studies of molecular effects of anti-arrhythmic action of omega-3 PUF-s is presented.
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Torshin
authors.forename: O A
authors.initials: OA
authors.lastname: Gromova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Egorova
authors.forename: K V
authors.initials: KV
authors.lastname: Rudakov
mesh_terms: D016718:Arachidonic Acid / Q000378:metabolism; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000378:metabolism; D001711:Biotransformation; D002317:Cardiovascular Agents / Q000378:metabolism / Q000494:pharmacology; D002986:Clinical Trials as Topic; D003580:Cytochromes / Q000378:metabolism; D004281:Docosahexaenoic Acids / Q000378:metabolism / Q000494:pharmacology; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid / Q000378:metabolism / Q000494:pharmacology; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000494:pharmacology; D006329:Heart Conduction System / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D018977:Micronutrients / Q000378:metabolism / Q000494:pharmacology; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism; D018055:Receptors, Eicosanoid / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000378:metabolism
chemical_list: D002317:Cardiovascular Agents; D003580:Cytochromes; D004338:Drug Combinations; D015525:Fatty Acids, Omega-3; D007473:Ion Channels; D018977:Micronutrients; D018055:Receptors, Eicosanoid; D011982:Receptors, Prostaglandin; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid; C405603:Omacor