title: Pre-operative factors that can predict neoplastic polypoid lesions of the gallbladder.
abstract: OBJECTIVE
  To investigate the preoperative factors that can predict neoplastic polypoid lesions of the gallbladder (PLGs) as well as malignant PLGs.
  
  
  METHODS
  A retrospective analysis was conducted on the 210 consecutively enrolled patients who underwent cholecystectomy due to a PLG larger than 10 mm, as was determined by preoperative trans-abdominal ultrasonography or endoscopic ultrasonography. We analyzed the medical, laboratory, radiologic data and the pathologic results.
  
  
  RESULTS
  In 210 cases, 146 had non-neoplastic polyps (69.5%) and 64 cases were neoplastic polyps (30.5%). An older age (≥ 65 years), the presence of diabetes mellitus (DM) and the size of polyp (≥ 15 mm) were revealed to be independent predictive variables for neoplastic polyps with odd ratios (OR) of 2.27 (P = 0.044), 2.64 (P = 0.021) and 4.94 (P < 0.01), respectively. Among the neoplastic PLGs, an older age (≥ 65 years), the presence of DM and polyp size (≥ 15 mm) were associated with malignancy with ORs of 4.97 (P = 0.005), 6.13 (P = 0.001) and 20.55 (P < 0.001), respectively.
  
  
  CONCLUSIONS
  Among patients with PLGs larger than 10 mm in size, higher risk groups such as elderly patients more than 65 years old, those with DM or a large polyp size (≥ 15 mm) should be managed by cholecystectomy.
authors.affiliation: Department of Internal Medicine, Cheju Halla General Hospital, Cheju-si, Cheju-do 690-766, South Korea.
authors.forename: Byung Hyo
authors.initials: BH
authors.lastname: Cha
authors.forename: Jin-Hyeok
authors.initials: JH
authors.lastname: Hwang
authors.forename: Sang Hyub
authors.initials: SH
authors.lastname: Lee
authors.forename: Jang Eon
authors.initials: JE
authors.lastname: Kim
authors.forename: Jai Young
authors.initials: JY
authors.lastname: Cho
authors.forename: Haeryoung
authors.initials: H
authors.lastname: Kim
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Kim
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003920:Diabetes Mellitus / Q000473:pathology; D005260:Female; D005706:Gallbladder Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D014463:Ultrasonography