title: A novel synthesis of N(1)-(substituted)-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones.
abstract: A new synthesis of N(1)-(substituted)-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones, which are analogues of the natural product toxoflavin, is reported. Condensation of preformed alkyl or aryl hydrazones with 6-chloro-3-methyl-5-nitrouracil efficiently provides pyrimidotriazinediones in a three-step process that broadens the scope of R(1) substituents.
authors.affiliation: Department of Medicinal Chemistry, University of Michigan, 428 Church St., Ann Arbor, MI 48109-1065, USA.
authors.forename: Anjanette J
authors.initials: AJ
authors.lastname: Turbiak
authors.forename: H D Hollis
authors.initials: HD
authors.lastname: Showalter