title: Clinical significance of interleukin-2/gamma interferon ratios in Mycobacterium tuberculosis-specific T-cell signatures.
abstract: The simultaneous determination of interleukin-2 (IL-2) and gamma interferon (IFN-γ) in QuantiFERON-TB test plasma supernatants permitted the detection of shifts in Mycobacterium tuberculosis-specific T-cell signatures. A subset of the 84 subjects tested revealed a significantly elevated IL-2/IFN-γ ratio, which may be a marker for the successful elimination of M. tuberculosis infection.
authors.affiliation: University of Bern, Institute for Infectious Diseases, Friedbühlstrasse 51, 3010 Bern, Switzerland. franziska.suter@ifik.unibe.ch
authors.forename: Franziska
authors.initials: F
authors.lastname: Suter-Riniker
authors.forename: Antonia
authors.initials: A
authors.lastname: Berger
authors.forename: Désirée
authors.initials: D
authors.lastname: Mayor
authors.forename: Pascal
authors.initials: P
authors.lastname: Bittel
authors.forename: Patricia
authors.initials: P
authors.lastname: Iseli
authors.forename: Thomas
authors.initials: T
authors.lastname: Bodmer
mesh_terms: D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014376:Tuberculosis / Q000175:diagnosis* / Q000276:immunology
chemical_list: D007376:Interleukin-2; D007371:Interferon-gamma