title: Nocturia in interstitial cystitis/painful bladder syndrome.
abstract: OBJECTIVE
  To explore the roles of pain and urgency in the nocturia of patients with interstitial cystitis/painful bladder syndrome (IC/PBS).
  
  
  METHODS
  In a longitudinal study of incident IC/PBS cases, we assessed the associations of the presence and severity of nocturia with the presence and severity of pain and urgency, using multivariate analyses when necessary. Additionally, we simply asked patients with IC/PBS what awakens them at night.
  
  
  RESULTS
  The multivariate analyses revealed associations of urgency with the presence and severity of nocturia and of bladder pain with the severity of nocturia. Direct queries of patients with IC/PBS about urgency and the reasons for awakening demonstrated that bladder pain might have played a twofold role: directly in awakening a large minority of patients and possibly indirectly in the majority by generating the sensation of urgency.
  
  
  CONCLUSIONS
  These findings are consistent with urinary urgency and bladder pain each being in the causal pathway leading to nocturia in patients with IC/PBS.
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. jwarren@medicine.umaryland.edu
authors.forename: John W
authors.initials: JW
authors.lastname: Warren
authors.forename: Linda
authors.initials: L
authors.lastname: Horne
authors.forename: Christina
authors.initials: C
authors.lastname: Diggs
authors.forename: Patty
authors.initials: P
authors.lastname: Greenberg
authors.forename: Patricia W
authors.initials: PW
authors.lastname: Langenberg
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003556:Cystitis / Q000150:complications / Q000175:diagnosis*; D018856:Cystitis, Interstitial / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D015999:Multivariate Analysis; D053158:Nocturia / Q000150:complications / Q000175:diagnosis*; D012307:Risk Factors; D001743:Urinary Bladder / Q000503:physiopathology