title: DNA replication: archaeal oriGINS.
abstract: GINS is an essential eukaryotic DNA replication factor that is found in a simplified form in Archaea. A new study in this issue of BMC Biology reveals the first structure of the archaeal GINS complex. The structure reveals the anticipated similarity to the previously determined eukaryotic complex but also has some intriguing differences in the relative disposition of subunit domains.
authors.affiliation: Sir William Dunn School of Pathology, Oxford OX1 3RE, UK. Stephen.bell@path.ox.ac.uk
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Bell
mesh_terms: D019843:Archaeal Proteins / Q000235:genetics* / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000378:metabolism; D004261:DNA Replication; D020836:Protein Structure, Quaternary; D019712:Thermococcus / Q000235:genetics* / Q000378:metabolism
chemical_list: D019843:Archaeal Proteins; D002868:Chromosomal Proteins, Non-Histone