title: Molecular analysis of blood with micro-/nanoscale field-effect-transistor biosensors.
abstract: Rapid and accurate molecular blood analysis is essential for disease diagnosis and management. Field-effect transistor (FET) biosensors are a type of device that promise to advance blood point-of-care testing by offering desirable characteristics such as portability, high sensitivity, brief detection time, low manufacturing cost, multiplexing, and label-free detection. By controlling device parameters, desired FET biosensor performance is obtained. This review focuses on the effects of sensing environment, micro-/nanoscale device structure, operation mode, and surface functionalization on device performance and long-term stability.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN 47907, USA.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Makowski
authors.forename: Albena
authors.initials: A
authors.lastname: Ivanisevic
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D001769:Blood / Q000378:metabolism*; D001774:Blood Chemical Analysis / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D036103:Nanotechnology / Q000295:instrumentation*; D012106:Research / Q000639:trends; D014173:Transistors, Electronic