title: Metabolic effects of pioglitazone in chemically-induced mammary carcinogenesis in rats.
abstract: In this paper, the effect of peroral antidiabetic pioglitazone, a thiazolidinedione derivate, on selected parameters of carbohydrate and lipid metabolism in N-methyl-N-nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats was evaluated. Pioglitazone was administered in the diet at two concentrations (10 ppm and 100 ppm), the chemoprevention was initiated 12 days before carcinogenesis induction and lasted until the termination of the experiment. The experiment was terminated 17 weeks after carcinogenesis induction, selected organs and tissues were removed and weighed and basic metabolic and hormonal parameters were determined. Pioglitazone increased glycemia (without exceeding normal values) and glycogen concentration in both liver and heart muscle without altering insulinemia and increased triacylglycerol concentration in liver, these changes were more prominent in group with higher dose. Pioglitazone also reduced corticosterone serum concentration and attenuated lipid peroxidation. Pioglitazone and other glitazones may be useful in alleviation of unfavourable metabolic changes in cancer patients.
authors.affiliation: Department of Animal Physiology, Institute of Biology and Ecology, Faculty of Science, P.J.Šafárik University, Moyzesova 11, 041 67 Košice, Slovak Republic. bianka.bojkova@upjs.sk
authors.forename: Bianka
authors.initials: B
authors.lastname: Bojková
authors.forename: Miroslava
authors.initials: M
authors.lastname: Garajová
authors.forename: Martin
authors.initials: M
authors.lastname: Péč
authors.forename: Peter
authors.initials: P
authors.lastname: Kubatka
authors.forename: Karol
authors.initials: K
authors.lastname: Kajo
authors.forename: Marián
authors.initials: M
authors.lastname: Mokáň
authors.forename: Monika
authors.initials: M
authors.lastname: Kassayová
authors.forename: Peter
authors.initials: P
authors.lastname: Orendáš
authors.forename: Terézia
authors.initials: T
authors.lastname: Kisková
authors.forename: Eva
authors.initials: E
authors.lastname: Ahlersová
authors.forename: Ivan
authors.initials: I
authors.lastname: Ahlers
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism; D005260:Female; D006003:Glycogen / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D006943:Hyperglycemia / Q000139:chemically induced / Q000378:metabolism; D006946:Hyperinsulinism / Q000139:chemically induced / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D008770:Methylnitrosourea; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D000077205:Pioglitazone; D051381:Rats; D017207:Rats, Sprague-Dawley; D045162:Thiazolidinediones / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D045162:Thiazolidinediones; D014280:Triglycerides; D008770:Methylnitrosourea; D006003:Glycogen; D003345:Corticosterone; D000077205:Pioglitazone