title: Synthesis and biological activity of chiral dihydropyrazole: potential lead for drug design.
abstract: Dihydropyrazole, a small bioactive molecule, is a prominent structural motif found in numerous pharmaceutically active compounds. The chiral dihydropyrazole structure has been demonstrated to bear important biological activities such as anticancer, antimicrobial, antimalarial, antinociceptive, antiviral, antitubercular, antiinflammatory, anticonvulsant and steroidal, and can also act as MAO inhibitors, CB1 receptor antagonists and nitric oxide synthase inhibitors. The review describes the latest advances in the synthesis of dihydropyrazole derivatives incorporating physiologically active substances. It is the first attempt at a general and systematic account of the extensive literature data on this subject.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China.
authors.forename: X-H
authors.initials: XH
authors.lastname: Liu
authors.forename: B-F
authors.initials: BF
authors.lastname: Ruan
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: F H
authors.initials: FH
authors.lastname: Chen
authors.forename: B-A
authors.initials: BA
authors.lastname: Song
authors.forename: H-L
authors.initials: HL
authors.lastname: Zhu
authors.forename: P S
authors.initials: PS
authors.lastname: Bhadury
authors.forename: J
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D008995:Monoamine Oxidase / Q000737:chemistry / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D000970:Antineoplastic Agents; D011720:Pyrazoles; D043884:Receptor, Cannabinoid, CB1; D019001:Nitric Oxide Synthase; D008995:Monoamine Oxidase