title: Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery.
abstract: A class of glycolipopeptides for use as building blocks for a new type of dynamic combinatorial library is reported. The members of the library consist of a variable carbohydrate moiety, coded amino acids, and lipoamino acids in order to convert them into amphiphiles. Glycolipopeptidic amphiphiles interact through non-covalent bonding when mixed together in aqueous phase and form micelles in dynamic close-packed fluid mosaic arrays. The head groups of amphiphiles are exposed on the micelle surface, providing entities which could be screened in biological assays to find the most potent combination of building blocks in order to identify new bioactive carbohydrate ligands.
authors.affiliation: The University of Queensland, School of Chemistry and Molecular Biosciences, Brisbane, Qld 4072, Australia.
authors.forename: Zyta M
authors.initials: ZM
authors.lastname: Ziora
authors.forename: Norbert
authors.initials: N
authors.lastname: Wimmer
authors.forename: Roger
authors.initials: R
authors.lastname: New
authors.forename: Mariusz
authors.initials: M
authors.lastname: Skwarczynski
authors.forename: Istvan
authors.initials: I
authors.lastname: Toth
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D004347:Drug Interactions; D006023:Glycoproteins / Q000737:chemistry; D057166:High-Throughput Screening Assays / Q000379:methods*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D019151:Peptide Library; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D000596:Amino Acids; D006023:Glycoproteins; D008024:Ligands; D008823:Micelles; D019151:Peptide Library; D011956:Receptors, Cell Surface; D054852:Small Molecule Libraries; D013501:Surface-Active Agents