title: [Drug induced hyponatremia. About a series of 54 cases notified to the regional center of pharmacovigilance of Saint-Étienne].
abstract: OBJECTIVE
  Analyze the most frequently reported drug in iatrogenic hyponatremia, explaining the mechanism in question.
  
  
  METHODS
  Retrospective study on 54 notified cases between the Jan.1(st) 2003 and Dec. 31(st) 2009. The analysis focuses on drug classes, accountability and mechanism; risk factors, severity and the evolution of the case.
  
  
  RESULTS
  Fourty-nine cases have been retained, 75,5% of the time it was an inappropriate secretion of antidiuretic hormone (SIADH) involving a selective serotonin reuptake inhibitor (SSRI) in 15 cases, an anticonvulsant in 7 cases, a proton pump inhibitor (PPI) in 7 cases or other drugs in 11. The hypo-osmolar hypovolemic hyponatremia was 12.2% of cases, incriminating a thiazide diuretic once in two. The mechanism was different or indeterminate in 12.2% of cases. In 67% cases were serious. The evolution was often favourable.
  
  
  CONCLUSIONS
  Drug induced hyponatremia can be serious. It must control natremia with patients at risk or symptomatic and conduct the etiological diagnosis.
authors.affiliation: Centre Regional de Pharmacovigilance, CHU de Saint-Etienne, Saint-Etienne, France. ivan.fenoglio@wanadoo.fr
authors.forename: Ivan
authors.initials: I
authors.lastname: Fenoglio
authors.forename: Claire
authors.initials: C
authors.lastname: Guy
authors.forename: Marie-Noëlle
authors.initials: MN
authors.lastname: Beyens
authors.forename: Geneviève
authors.initials: G
authors.lastname: Mounier
authors.forename: Fakhria
authors.initials: F
authors.lastname: Marsille
authors.forename: Patrick
authors.initials: P
authors.lastname: Mismetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000009:adverse effects; D002648:Child; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000453:epidemiology; D007177:Inappropriate ADH Syndrome / Q000150:complications; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D060735:Pharmacovigilance; D054328:Proton Pump Inhibitors / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D054328:Proton Pump Inhibitors; D017367:Selective Serotonin Reuptake Inhibitors