title: A randomised controlled trial evaluating the use of polyglactin (Vicryl) mesh, polydioxanone (PDS) or polyglactin (Vicryl) sutures for pelvic organ prolapse surgery: outcomes at 2 years.
abstract: The effects at 2 years of polyglactin (Vicryl) mesh inlay and polydioxanone (PDS) or polyglactin (Vicryl) suture material on prolapse symptoms, urinary, bowel, sexual function and prolapse related Quality-of-Life (QoL) in women undergoing pelvic organ prolapse surgery were evaluated in a randomised controlled trial with a 2 × 2 factorial design of Vicryl mesh (n = 32) or not (n = 34) and PDS (n = 33) or Vicryl suture (n = 33). The response rate at 2 years was 82%. There were no differences in the prolapse symptom scores between the randomised groups. Prolapse-related QoL score (mean difference: 2.05, 95% CI 0.19-3.91) and urinary incontinence score (mean difference: 2.56, 95% CI 0.02-5.11) were significantly lower (better) in women who had Vicryl compared with PDS sutures. The apparent superiority of the prolapse-related QoL and urinary incontinence scores in women using Vicryl suture material (vs PDS) needs to be confirmed in a larger trial.
authors.affiliation: Sheffield Teaching Hospital, Sheffield, UK. priyamadhuvrata@nhs.net
authors.forename: P
authors.initials: P
authors.lastname: Madhuvrata
authors.forename: C
authors.initials: C
authors.lastname: Glazener
authors.forename: C
authors.initials: C
authors.lastname: Boachie
authors.forename: S
authors.initials: S
authors.lastname: Allahdin
authors.forename: C
authors.initials: C
authors.lastname: Bain
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects / Q000295:instrumentation*; D006801:Humans; D008875:Middle Aged; D017060:Patient Satisfaction; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D016687:Polydioxanone; D011098:Polyglactin 910; D011183:Postoperative Complications / Q000209:etiology*; D011788:Quality of Life; D012735:Sexual Dysfunction, Physiological; D013526:Surgical Mesh; D013537:Sutures; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000209:etiology
chemical_list: D016687:Polydioxanone; D011098:Polyglactin 910