title: Alternatively spliced tissue factor pathway inhibitor: functional implications.
abstract: Tissue factor pathway inhibitor (TFPI) is a factor Xa dependent inhibitor of tissue factor initiated blood coagulation. In recent years several alternatively spliced forms of TFPI have been identified. These alternatively spliced forms have different C-terminal regions and have different mechanisms for association with cell surfaces. They are differentially expressed in human and mouse tissues and may have distinct physiological functions.
authors.affiliation: Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201-2178, USA. alan.mast@bcw.edu
authors.forename: Alan E
authors.initials: AE
authors.lastname: Mast
mesh_terms: D017398:Alternative Splicing / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D019143:Evolution, Molecular; D065427:Factor Xa Inhibitors; D006801:Humans; D008074:Lipoproteins / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D013045:Species Specificity
chemical_list: D065427:Factor Xa Inhibitors; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor