title: Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome.
abstract: OBJECTIVE
  To determine the prevalence and clinical and metabolic correlates of sleep-disordered breathing (SDB) and excessive daytime sleepiness (EDS) in adolescent girls with polycystic ovarian syndrome (PCOS).
  
  
  METHODS
  Standardized questionnaires were administered to participants with PCOS and age-, sex-, ethnicity-, and body mass index (BMI) z score-matched controls. Medical records were reviewed for anthropometric and metabolic data.
  
  
  RESULTS
  We studied 103 participants with PCOS (16.9 ± 1.5 years) and 90 controls (16.8 ± 1.7 years). Compared with controls, girls with PCOS had a higher prevalence of SDB (45.6% vs 27.8%; P = .01) and EDS (54.4% vs 35.6%; P < .01). Within PCOS, those with SDB had higher BMI z score (2.1 ± 0.5 vs 1.7 ± 0.6; P < .01), higher homeostatic model assessment index (5.1 ± 2.3 vs 4.1 ± 3.5; P < .01), and higher prevalence of the metabolic syndrome (MetS) (42.6% vs 16.1%; P = .003) compared with those without SDB. Similarly, participants with PCOS and EDS had a higher BMI z score (2.0 ± 0.6 vs 1.7 ± 0.6; P = .03), higher homeostatic model assessment index (5.1 ± 2.9 vs 3.8 ± 3.1; P = .01), and higher rate of MetS (39.3% vs. 14.9%; P < .01) compared with those without EDS. MetS was independently associated with SDB (OR, 3.2; 95% CI, 1.0-10.1) and EDS (OR, 4.5; 95% CI, 1.2-16).
  
  
  CONCLUSIONS
  SDB and EDS are highly prevalent in adolescent girls with PCOS compared with matched controls. The MetS is independently associated with SDB and EDS in this group.
authors.affiliation: Division of Respiratory and Sleep Medicine, Department of Pediatrics, Children's Hospital at Montefiore, Bronx, NY 10467-2490, USA.
authors.forename: Kiran
authors.initials: K
authors.lastname: Nandalike
authors.forename: Temima
authors.initials: T
authors.lastname: Strauss
authors.forename: Chhavi
authors.initials: C
authors.lastname: Agarwal
authors.forename: Susan M
authors.initials: SM
authors.lastname: Coupey
authors.forename: Sanghun
authors.initials: S
authors.lastname: Sin
authors.forename: Swapnil
authors.initials: S
authors.lastname: Rajpathak
authors.forename: Hillel W
authors.initials: HW
authors.lastname: Cohen
authors.forename: Raanan
authors.initials: R
authors.lastname: Arens
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D006970:Disorders of Excessive Somnolence / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D016015:Logistic Models; D024821:Metabolic Syndrome / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D015995:Prevalence; D012189:Retrospective Studies; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000175:diagnosis; D011795:Surveys and Questionnaires
chemical_list: D007328:Insulin