title: Oleanene triterpenes from Sedum lineare Thunb.
abstract: One new olean-13(18)-ene-3,12,19-trione (1), and two known oleanene triterpenes δ-amyrone (2), and δ-amyrine acetate (3) were isolated from the petroleum ether fraction from an alcoholic extract of the whole plant of Sedum linear Thunb. The new compound was characterized by means of spectroscopic methods including 1D, 2D NMR and HR-ESI-MS, and was further confirmed by X-ray diffraction analysis. The known ones were established on the basis of comparing their NMR data with those of the corresponding compounds in the literature. In addition, the inhibitory effects of the compounds isolated on the TNF-α and NO production were examined in vitro.
authors.affiliation: aculty of Pharmacy, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, PR China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Niu
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.forename: Lan
authors.initials: L
authors.lastname: Pan
authors.forename: Lin
authors.initials: L
authors.lastname: Qi
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D031963:Sedum / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014961:X-Ray Diffraction
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D014315:Triterpenes; D014409:Tumor Necrosis Factor-alpha; C570369:olean-13(18)-ene-3,12,19-trione; D009569:Nitric Oxide; D009828:Oleanolic Acid