title: The lipopolysaccharide core of Actinobacillus suis and its relationship to those of Actinobacillus pleuropneumoniae.
abstract: The Gram-negative bacteria Actinobacillus suis colonizes the upper respiratory and genital tracts of swine. Along with capsular polysaccharides, lipopolysaccharides (O-chain→core→lipid A~cell) are a main cell-surface component of A. suis. In this study, we determined that A. suis lipopolysaccharide incorporates a conserved core that shares some structural features with several core types of A. pleuropneumoniae . These common core structural features likely account for the observed serological cross-reactivity between A. suis and A. pleuropneumoniae, and the data suggest that the structural epitopes responsible for immunogenicity are those in the outer core domain.
authors.affiliation: Department of Chemistry, University of Guelph, Canada.
authors.forename: Jeyabarathy
authors.initials: J
authors.lastname: Ganeshapillai
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Boncheff
authors.forename: Durda
authors.initials: D
authors.lastname: Slavic
authors.forename: Janet
authors.initials: J
authors.lastname: MacInnes
authors.forename: Mario A
authors.initials: MA
authors.lastname: Monteiro
mesh_terms: D000189:Actinobacillus Infections / Q000276:immunology / Q000382:microbiology*; D016977:Actinobacillus pleuropneumoniae / Q000737:chemistry* / Q000276:immunology; D044132:Actinobacillus suis / Q000737:chemistry* / Q000276:immunology; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000276:immunology; D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology; D016667:Bacterial Capsules / Q000737:chemistry / Q000276:immunology; D002240:Carbohydrate Sequence; D017124:Conserved Sequence; D008070:Lipopolysaccharides / Q000737:chemistry* / Q000276:immunology / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D019081:O Antigens / Q000032:analysis / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000737:chemistry* / Q000276:immunology; D012703:Serotyping; D034421:Sus scrofa / Q000276:immunology / Q000382:microbiology*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; C030659:K antigens; D008070:Lipopolysaccharides; D019081:O Antigens; D011135:Polysaccharides, Bacterial