title: Gene expression in blood is associated with risperidone response in children with autism spectrum disorders.
abstract: Children with autism spectrum disorders (ASDs) often have severe behavioral problems. Not all children with these problems respond to atypical antipsychotic medications; therefore, we investigated whether peripheral blood gene expression before treatment with risperidone, an atypical antipsychotic, was associated with improvements in severe behavioral disturbances 8 weeks following risperidone treatment in 42 ASD subjects (age 112.7±51.2 months). Exon expression levels in blood before risperidone treatment were compared with pre-post risperidone change in Aberrant Behavior Checklist-Irritability (ABC-I) scores. Expression of exons within five genes was correlated with change in ABC-I scores across all risperidone-treated subjects: GBP6, RABL5, RNF213, NFKBID and RNF40 (α<0.001). RNF40 is located at 16p11.2, a region implicated in autism and schizophrenia. Thus, these genes expressed before treatment were associated with subsequent clinical response. Future studies will be needed to confirm these results and determine whether this expression profile is associated with risperidone response in other disorders, or alternative antipsychotic response within ASD.
authors.affiliation: Department of Neurology, University of California, Davis, MIND Institute, Davis, CA 95817, USA. llit@ucdavis.edu
authors.forename: L
authors.initials: L
authors.lastname: Lit
authors.forename: F R
authors.initials: FR
authors.lastname: Sharp
authors.forename: K
authors.initials: K
authors.lastname: Bertoglio
authors.forename: B
authors.initials: B
authors.lastname: Stamova
authors.forename: B P
authors.initials: BP
authors.lastname: Ander
authors.forename: A D
authors.initials: AD
authors.lastname: Sossong
authors.forename: R L
authors.initials: RL
authors.lastname: Hendren
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage*; D054316:Biomarkers, Pharmacological / Q000097:blood; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000097:blood* / Q000235:genetics / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D056726:Genetic Association Studies; D006801:Humans; D007223:Infant; D008297:Male; D018967:Risperidone / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D054316:Biomarkers, Pharmacological; D018967:Risperidone