title: Efficient three-step one-pot synthesis of a novel 2,3,5-substituted pyrazine library.
abstract: The partnership between rational synthesis design and mass-triggered preparative LCMS is a powerful one, capable of furnishing very large libraries in a selective manner in a very short space of time. Herein, we communicate one example of possibly a perfect marriage between the synthetic chemistry and the subsequent purification method employed, affording a ∼1000-member library supplying 50 mg on average of final compound in less than a month.
authors.affiliation: AstraZeneca, Centre de Recherches, Z.I. la Pompelle, Reims, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Delvare
authors.forename: Craig S
authors.initials: CS
authors.lastname: Harris
authors.forename: Laurent
authors.initials: L
authors.lastname: Hennequin
authors.forename: Patrice
authors.initials: P
authors.lastname: Koza
authors.forename: Christine
authors.initials: C
authors.lastname: Lambert-van der Brempt
authors.forename: Jacques
authors.initials: J
authors.lastname: Pelleter
authors.forename: Olivier
authors.initials: O
authors.lastname: Willerval
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011719:Pyrazines; D054852:Small Molecule Libraries