title: Distribution of inflammatory cells, adhesion molecules, intermediate filaments, and chemokine receptors in subgroups of nasal polyp patients.
abstract: BACKGROUND
  The pathogenesis of nasal polyps (NPs) is incompletely understood. The aim of this study was to investigate the distribution of inflammatory cells, adhesion molecules, intermediate filaments, and chemokine receptors in subgroups of NP patients.
  
  
  METHODS
  In total, 35 patients were enrolled (group 1, 10 patients with Samter syndrome; group 2, 10 patients with diffuse polyposis without signs of Samter syndrome; group 3: 5 patients with solitary nasal polyps; group 4, 10 controls). Immunohistochemical staining was performed for CD105, CD106, CD62E, CD4, CD8, CXCR4, CD147, CD90, CD104, BF45, vimentin, pancytokeratin, and muscle-specific actin (MSA) in all patients' specimens.
  
  
  RESULTS
  Expression of CD4, CD8, and CD106 were similar between the groups. Number of patients expressing CD4 in groups 1, 2, and 3 were higher than the controls. Number of patients expressing CD8 antigen were significantly higher in all three groups than in the control group. Expression of CD147 in groups 3 and 4 was significantly higher than in groups 1 and 2. CD98 expression was higher in groups 1, 2, and 3 than in group 4. The number of patients expressing vimentin in groups 1, 2, and 3 was significantly higher than in group 4. Immunostaining for pancytokeratin was positive in all patients.
  
  
  CONCLUSIONS
  In conclusion, inflammatory cell, adhesion molecule, intermediate filament, and chemokine receptor profiles in nasal polyps differ among different patient groups and control subjects. Additional specific immunohistochemical studies are necessary for development of more specific immunotherapies.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Onerci
authors.forename: Cagdas
authors.initials: C
authors.lastname: Elsurer
authors.forename: Elif E
authors.initials: EE
authors.lastname: Guzel
authors.forename: Attila
authors.initials: A
authors.lastname: Dagdeviren
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D007382:Intermediate Filaments / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000276:immunology*; D019707:Receptors, Chemokine / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D019707:Receptors, Chemokine