title: [Chondrocyte metabolism may be regulated through the interaction with the extracellular matrix].
abstract: Articular chondrocytes are the sole type of cell that resides within articular cartilage. The chondrocytes are very sensitive to the matrix around the cells. This is best illustrated by the dramatic change in cell shape and metabolism that occurs during monolayer culture. Although this change, or dedifferentiation, has been known for decades, an underlying mechanism (s) for the change has not yet been determined. Recently, we have reported thatαvβ5 integrin is significantly involved in the change through the activation of ERK signaling. This review describes our recent findings about the dedifferentiation of monolayer-cultured chondrocytes.
authors.affiliation: Graduate School of Arts and Sciences, the University of Tokyo, Tokyo, Japan.
authors.forename: Naoshi
authors.initials: N
authors.lastname: Fukui
mesh_terms: D002358:Cartilage, Articular / Q000166:cytology*; D002454:Cell Differentiation / Q000235:genetics; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism*; D005109:Extracellular Matrix / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D006801:Humans; D039564:Integrin alphaV / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D039564:Integrin alphaV; D048049:Extracellular Signal-Regulated MAP Kinases