title: Post-operative Changes of Cerebral Glucose Metabolism in Patients with Lumbar Spinal Stenosis with Pre-operative Anxiety: Statistical Parametric Mapping Analysis of F-18 FDG Brain PET.
abstract: METHODS
  A prospective study.
  
  
  OBJECTIVE
  To assess postoperative changes in cerebral glucose metabolism in anxiety patients with lumbar spinal stenosis (SS).
  
  
  BACKGROUND
  Although an association between preoperative anxiety and abnormal cerebral glucose metabolism may exist, only a limited number of studies using F-18 fluorodeoxyglucose positron emission tomography (FDG PET) have evaluated preoperative to postoperative changes in cerebral glucose metabolism in SS patients in detail.
  
  
  METHODS
  The present study was designed to assess preoperative to postoperative changes in cerebral glucose metabolism in anxiety patients with SS. F-18 FDG PET with statistical parametric mapping analyses was used to compare preoperative and postoperative regional brain glucose metabolism in 18 SS patients.
  
  
  RESULTS
  F-18 FDG PET scans showed postoperative activation of several brain clusters in gray matter. These included left parahippocampus, left cerebellar tonsil, left inferior semi-lunar lobule, and right cerebellar tonsil. Areas that were deactivated postoperatively were the right insula, left fusiform gyrus, left orbitofrontal cortex, left inferior frontal gyrus, left middle frontal gyrus, left precuneus, and left inferior frontal gyrus.
  
  
  CONCLUSIONS
  SS patients with preoperative anxiety showed altered cerebral glucose metabolism at postoperative follow-up.
authors.affiliation: Department of Nuclear Medicine, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Seong-Jang
authors.initials: SJ
authors.lastname: Kim
authors.forename: Kuen Tak
authors.initials: KT
authors.lastname: Suh
authors.forename: Jeung Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Lim
authors.forename: Tae Sik
authors.initials: TS
authors.lastname: Goh
authors.forename: Jung Sub
authors.initials: JS
authors.lastname: Lee