title: Illness-induced changes in thyroid hormone metabolism: focus on the tissue level.
abstract: During illness changes in thyroid hormone metabolism occur, collectively known as the non-thyroidal illness syndrome (NTIS). NTIS is characterised by low serum thyroid hormone levels without the expected rise in serum thyroid-stimulating hormone, indicating a major change in thyroid hormone feedback regulation. Recent studies have made clear that during NTIS differential changes in thyroid hormone metabolism occur in various tissues, the net effect of which may be either activation or inhibition of thyroid hormone action. In this review we discuss systemic and local changes in thyroid hormone metabolism during illness, highlighting their physiological implications in terms of disease course.
authors.affiliation: Department of Endocrinology & Metabolism, Academic Medical Center, University of Amsterdam, the Netherlands. g.j.kwakkel@amc.uva.nl
authors.forename: J
authors.initials: J
authors.lastname: Kwakkel
authors.forename: E
authors.initials: E
authors.lastname: Fliers
authors.forename: A
authors.initials: A
authors.lastname: Boelen
mesh_terms: D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007453:Iodide Peroxidase / Q000097:blood / Q000378:metabolism*; D013577:Syndrome; D013959:Thyroid Diseases / Q000097:blood / Q000378:metabolism*; D013963:Thyroid Hormones / Q000097:blood / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism
chemical_list: D013963:Thyroid Hormones; D013972:Thyrotropin; D007453:Iodide Peroxidase