title: Expression of interleukin-22 in Sjögren's syndrome: significant correlation with disease parameters.
abstract: Sjögren's syndrome (SS) is an autoimmune disease targeting the exocrine glands resulting in xerostomia/keratoconjunctivitis sicca. Presently, we examined the levels and clinical correlations of IL-22 in SS. Patients with SS together with normal controls were randomly selected. IL-22 was detected at significantly higher levels in sera of patients with SS. The levels of IL-22 present in sera showed statistically significant direct correlations with hyposalivation, anti-SSB, anti-SSA/SSB combined, hypergammaglobulinemia and rheumatoid factor. IL-22 showed a direct correlation with major clinical parameters. The data suggest that IL-22 plays a critical role in the development of SS, and further study is needed to examine its function in human SS.
authors.affiliation: Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
authors.forename: T N
authors.initials: TN
authors.lastname: Lavoie
authors.forename: C M
authors.initials: CM
authors.lastname: Stewart
authors.forename: K M
authors.initials: KM
authors.lastname: Berg
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: C Q
authors.initials: CQ
authors.lastname: Nguyen
mesh_terms: D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005088:Exocrine Glands / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D007378:Interleukins / Q000096:biosynthesis / Q000097:blood*; D007638:Keratoconjunctivitis Sicca / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000276:immunology; D012859:Sjogren's Syndrome / Q000097:blood* / Q000276:immunology; D014987:Xerostomia / Q000276:immunology; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D012217:Rheumatoid Factor; D000097043:Interleukin-22