title: 3-haloquinolines by Friedländer reaction of α-haloketones.
abstract: A general approach to 3-fluoro-, 3-chloro-, and 3-bromoquinolines which relies on organosilane-promoted Friedländer reaction of α-haloketones is described. The scope of the methylene component as well as influence of the organosilane component on the outcome of the reaction is studied. The method can be used under parallel synthesis conditions.
authors.affiliation: Kyiv National Taras Shevchenko University, Kyiv, Ukraine. s.v.ryabukhin@gmail.com
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Ryabukhin
authors.forename: Vasiliy S
authors.initials: VS
authors.lastname: Naumchik
authors.forename: Andrey S
authors.initials: AS
authors.lastname: Plaskon
authors.forename: Oleksandr O
authors.initials: OO
authors.lastname: Grygorenko
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Tolmachev
mesh_terms: D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D011804:Quinolines