title: Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress.
abstract: BACKGROUND
  To study the association between lipid-metabolism and depressive symptoms, genetic polymorphisms in serotonin transporter linked promoter region (5-HTTLPR) and fatty acid synthase gene (FASN) were investigated.
  
  
  METHODS
  A cross-sectional study was conducted on 177 women (n = 166) and men (n = 15) recruited from workers in a hospital and nursing homes in Japan. Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression (CES-D) scale and perceived psychological stress was measured using visual analogue scale (VAS). The genotypes of 5-HTTLPR (insertion/deletion; L/S), and FASN (Val1483Ile) were determined by the PCR methods. Linear regression analysis was performed, in which CES-D scores served as a dependent variable, and VAS scores, gene polymorphism, and confounders as independent variables.
  
  
  RESULTS
  Under the influence of perceived stress, S/S carriers of the 5-HTTLPR gene showed significantly higher CES-D scores in comparison with L/L+L/S carriers (F = 8.2, standardised β = 0.15, p < 0.05). Regression analysis also confirmed that CES-D scores in participants with Ile/Ile+Val/Ile genotypes of the FASN gene were significantly higher than those with Val/Val genotype (F = 8.4, standardised β = 0.16, p<0.05). In relation to physical features, BMI among participants with S/S genotype of 5-HTTLPR was significantly lower compared with those with L/L+L/S genotypes.
  
  
  CONCLUSIONS
  The Val1483Ile polymorphism in the FASN was associated with depressive symptoms under the influence of psychological stress. The S variant of 5-HTTLPR was related with less obese.
authors.affiliation: Department of Drug Management and Policy, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. yayevgeny@livedoor.com
authors.forename: Hirohito
authors.initials: H
authors.lastname: Tsuboi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakakibara
authors.forename: Kimiko
authors.initials: K
authors.lastname: Yamakawa-Kobayashi
authors.forename: Asami
authors.initials: A
authors.lastname: Tatsumi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Inamori
authors.forename: Reiko
authors.initials: R
authors.lastname: Hamamoto
authors.forename: Atsuko
authors.initials: A
authors.lastname: Suzuki
authors.forename: Kayoko
authors.initials: K
authors.lastname: Shimoi
mesh_terms: D000328:Adult; D000483:Alleles; D003430:Cross-Sectional Studies; D003863:Depression / Q000235:genetics*; D003866:Depressive Disorder / Q000235:genetics; D016021:Epidemiologic Studies; D054890:Fatty Acid Synthase, Type I / Q000235:genetics*; D064429:Fatty Acid Synthases / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007532:Isoleucine / Q000235:genetics; D007564:Japan; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013315:Stress, Psychological / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D007532:Isoleucine; C518729:FASN protein, human; D054890:Fatty Acid Synthase, Type I; D064429:Fatty Acid Synthases