title: Association between polymorphism of the tumor necrosis factor alpha-308 gene promoter and colon cancer in the Chinese population.
abstract: Tumor necrosis factor (TNF) is a type of cytokine that inhibits tumorigenesis. Several studies have assessed the relationship between the polymorphism of TNF-alpha 308G/A and the susceptibility to colon cancer; however, the results have been controversial. A case-control study was carried out to investigate whether TNF-alpha 308G/A gene polymorphism was associated with the risk of colon cancer in a group of 180 cases and 180 controls from Heilongjiang, China. DNA was isolated from peripheral blood, and gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Results of our study showed that colon cancer cases had a significantly higher frequency of TNF-alpha 308AA genotype (odds ratio=9.42, 95% confidence interval=1.18, 75.15; p=0.03) than controls. When stratified by the tumor location, tumor size, growth pattern, differentiation, and stage of colon cancer, no statistically significant results was observed. The present study demonstrated that TNF-alpha 308AA genotype was associated with a higher risk of colon cancer in the Chinese population. Confirmation of these findings in other populations is required.
authors.affiliation: Department of Colorectal Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: Mingqi
authors.initials: M
authors.lastname: Li
authors.forename: Qi
authors.initials: Q
authors.lastname: You
authors.forename: Xishan
authors.initials: X
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People; D002681:China / Q000453:epidemiology; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha