title: In vivo MRI-based 3D mechanical stress-strain profiles of carotid plaques with juxtaluminal plaque haemorrhage: an exploratory study for the mechanism of subsequent cerebrovascular events.
abstract: OBJECTIVE
  Atherosclerotic plaque features, such as fibrous cap erosion, ulceration and rupture and presence of haemorrhage in carotid plaque are two important characteristics associated with subsequent cerebrovascular events and juxtaluminal haemorrhage/thrombus (JLH/T) indicates these two high-risk characteristics. This study aims to investigate the association between JLH/T and subsequent events in patients suffering from transient ischaemic attack (TIA). Three-dimensional mechanical analysis was employed to represent the critical mechanical stress (P-CStress) and stretch (P-CStretch) within the plaque.
  
  
  METHODS
  Fifty TIA patients with mild-to-moderate carotid stenosis (30-69%) underwent high-resolution magnetic resonance imaging (MRI) within 72 h of the acute event and eight were excluded from the analysis due to various reasons. A total of 21 patients were found to have JLH/T in the carotid plaque and 21 did not (N-JLH/T). During a 2-year follow-up period, 11 (52.4%) patients in the JLH/T group experienced recurrent events and none in the N-JLH/T group. Three-dimensional plaque structure was reconstructed based on the in vivo MRI for the mechanical analysis.
  
  
  RESULTS
  P-CStress of both groups was comparable (N-JLH/T: 174.45 ± 63.96 kPa vs. JLH/T: 212.60 ± 89.54 kPa; p = 0.120), but P-CStretch of JLH/T was significantly bigger than that of N-JLH/T (N-JLH/T: 1.21 ± 0.08 vs. JLH/T: 2.10 ± 0.53; p < 0.0001). Moreover, there were much bigger variations in stress and stretch of the JLH/T group during one cardiac cycle than in those of N-JLH/T group.
  
  
  CONCLUSIONS
  In vivo MRI-depicted JLH/T might be a high risk factor initiating recurrent events, as big deformation appearing around the rupture site might prevent healing and tear the haemorrhage/thrombus away from the host structure and prompt further thrombo-embolic events.
authors.affiliation: University Department of Radiology, University of Cambridge, Level 5, Box 218, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ, UK. zt215@cam.ac.uk
authors.forename: Z
authors.initials: Z
authors.lastname: Teng
authors.forename: U
authors.initials: U
authors.lastname: Sadat
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: V E
authors.initials: VE
authors.lastname: Young
authors.forename: M J
authors.initials: MJ
authors.lastname: Graves
authors.forename: J
authors.initials: J
authors.lastname: Lu
authors.forename: J H
authors.initials: JH
authors.lastname: Gillard
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002343:Carotid Artery, Internal / Q000473:pathology / Q000503:physiopathology; D016893:Carotid Stenosis / Q000150:complications / Q000503:physiopathology*; D005260:Female; D020342:Finite Element Analysis; D006470:Hemorrhage / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D002546:Ischemic Attack, Transient / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D058226:Plaque, Atherosclerotic / Q000175:diagnosis / Q000503:physiopathology*; D012008:Recurrence; D013314:Stress, Mechanical