title: [Transcriptional regulation of osteoarthritis].
abstract: Osteoarthritis (OA) is one of the most common skeletal disorders characterized by cartilage degradation ; however, little was known about the underlying molecular mechanism. Several experimental OA models in mice by producing instability in the knee joints have been developed, and many molecules and signals have been shown to be involved with OA progression through in vivo analyses using mouse OA models. Recently we identified hypoxia-inducible factor-2α (HIF2A) as an extensive regulator of the endochondal ossification process. We have shown that HIF2A, which is induced by the NF-κB signal, controls OA progression by inducing various target molecules.
authors.affiliation: Department of Bone & Cartilage Regenerative Medicine, University of Tokyo Hospital, Tokyo, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Saito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
mesh_terms: D000818:Animals; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000502:physiology; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000502:physiology; D010003:Osteoarthritis / Q000235:genetics*; D010012:Osteogenesis / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics*; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D051792:Basic Helix-Loop-Helix Proteins; D016328:NF-kappa B; D000099162:Endothelial PAS Domain-Containing Protein 1