title: [Prognostic value of various markers of inflammation in ST-elevation myocardial infarction].
abstract: We measured levels of several parameters of immune inflammation (interleukins [IL] 1, 6, 8, 10, 12, tumor necrosis factor [TNF], serum neopterin, C-reactive protein) on days 10-14 after onset of ST segment elevation myocardial infarction (MI) and related them to results of 12 months follow up. Elevated titers of IL-12 and neopterin were significantly associated with unfavorable events (repetitive MI, progression of angina, stroke, decompensation of chronic heart failure) (=0.001 and =0.003, respectively). After adjustment for initial severity of MI only IL-12 retained its prognostic value (=0.05). Regression analysis identified IL-12 level &gt;108.7 g/ml and TIMI score &gt; 3 as independent predictors of combined end point formation. Prognostic value of IL-12 level was significant both among patients with TIMI scores &lt;3 and more or equal 4.
authors.forename: O L
authors.initials: OL
authors.lastname: Barbarash
authors.forename: M V
authors.initials: MV
authors.lastname: Zykov
authors.forename: V V
authors.initials: VV
authors.lastname: Kashtalap
authors.forename: A V
authors.initials: AV
authors.lastname: Osokina
authors.forename: S A
authors.initials: SA
authors.lastname: Berns
authors.forename: V N
authors.initials: VN
authors.lastname: Karetnikova
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D018450:Disease Progression; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D015425:Myocardial Reperfusion; D019798:Neopterin / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D055502:Secondary Prevention; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D019798:Neopterin; D002097:C-Reactive Protein