title: Effect of donor/recipient body weight ratio, donor weight, recipient weight and donor age on kidney graft function in children.
abstract: BACKGROUND
  We hypothesized that supplementing a higher mass of renal parenchyma from adult donors, and their younger age, would improve graft function in paediatric recipients.
  
  
  METHODS
  We calculated estimated glomerular filtration rate (eGFR; Schwartz formula) and absolute glomerular filtration rate (absGFR) in 57 renal-grafted children (1995-2007) aged 3.1-17.9 years, weighing 12.9-85.0 kg, on discharge from the hospital after transplantation (TPL), 1 year after TPL and at the last follow-up (1.5-11.7 years after TPL). We correlated their eGFR with the individual ratio between the donor and the recipient body weight at the time of TPL (donor/recipient body weight ratio; D/R BWR), and we evaluated the effect of the donor and the actual recipient body weight on the eGFR and absGFR.
  
  
  RESULTS
  The D/R BWR varied from 0.65 to 5.23. We found a significant positive correlation between D/R BWR and eGFR at discharge from the hospital (P < 0.001), 1-year post-TPL (P < 0.001) and at the last follow-up (P < 0.05). Using multiple linear regression analyses, we found that both eGFR and absGFR values were much more determined by the actual recipient weight than by the donor weight (27/6% and 43/4% at discharge, by 24/4% and 57/0% 1 year after TPL, and 0/0% and 20/0% at the end of the follow-up). A tendency for lower eGFR with increasing age of donors was apparent at discharge and 1 year after TPL, but it reached statistical significance only at the last follow-up (r = 0.4254, P < 0.01).
  
  
  CONCLUSIONS
  In paediatric renal transplants, the value of D/R BWR directly correlated with eGFR in the early and late posttransplant periods. However, this correlation was mainly influenced by the recipient weight, while the donor weight played only a minor or negligible role.
authors.affiliation: Transplantation Centre, University Hospital Motol, Prague, Czech Republic.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Špatenka
authors.forename: Tomáš
authors.initials: T
authors.lastname: Seeman
authors.forename: Eva
authors.initials: E
authors.lastname: Foltynová
authors.forename: Jan
authors.initials: J
authors.lastname: Burkert
authors.forename: Jiří
authors.initials: J
authors.lastname: Dušek
authors.forename: Karel
authors.initials: K
authors.lastname: Vondrák
authors.forename: Jan
authors.initials: J
authors.lastname: Janda
authors.forename: Anna
authors.initials: A
authors.lastname: Habrmanová
authors.forename: Jana
authors.initials: J
authors.lastname: Krejčová
authors.forename: Karel
authors.initials: K
authors.lastname: Matoušovic
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D007902:Length of Stay; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D018570:Risk Assessment; D013997:Time Factors; D014019:Tissue Donors