title: EGG molecules couple the oocyte-to-embryo transition with cell cycle progression.
abstract: The oocyte-to-embryo transition is a precisely coordinated process in which an oocyte becomes fertilized and transitions to an embryonic program of events. The molecules involved in this process have not been well studied. Recently, a group of interacting molecules in C. elegans have been described as coordinating the oocyte-to-embryo transition with the advancement of the cell cycle. Genes egg-3, egg-4, and egg-5 represent a small class of regulatory molecules known as protein-tyrosine phosphase-like proteins, which can bind phosphorylated substrates and act as scaffolding molecules or inhibitors. These genes are responsible for coupling the movements and activities of regulatory kinase mbk-2 with advancement of the cell cycle during the oocyte-to-embryo transition.
authors.affiliation: Waksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
authors.forename: Jean M
authors.initials: JM
authors.lastname: Parry
authors.forename: Andrew
authors.initials: A
authors.lastname: Singson
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000196:embryology* / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000502:physiology*; D002453:Cell Cycle / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000166:cytology* / Q000502:physiology; D005260:Female; D009865:Oocytes / Q000166:cytology*; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000502:physiology
chemical_list: D029742:Caenorhabditis elegans Proteins; C525138:EGG-3 protein, C elegans; D017027:Protein Tyrosine Phosphatases