title: Failure tolerance of motif structure in biological networks.
abstract: Complex networks serve as generic models for many biological systems that have been shown to share a number of common structural properties such as power-law degree distribution and small-worldness. Real-world networks are composed of building blocks called motifs that are indeed specific subgraphs of (usually) small number of nodes. Network motifs are important in the functionality of complex networks, and the role of some motifs such as feed-forward loop in many biological networks has been heavily studied. On the other hand, many biological networks have shown some degrees of robustness in terms of their efficiency and connectedness against failures in their components. In this paper we investigated how random and systematic failures in the edges of biological networks influenced their motif structure. We considered two biological networks, namely, protein structure network and human brain functional network. Furthermore, we considered random failures as well as systematic failures based on different strategies for choosing candidate edges for removal. Failure in the edges tipping to high degree nodes had the most destructive role in the motif structure of the networks by decreasing their significance level, while removing edges that were connected to nodes with high values of betweenness centrality had the least effect on the significance profiles. In some cases, the latter caused increase in the significance levels of the motifs.
authors.affiliation: Department of Computer Engineering, Sharif University of Technology, Tehran, Iran.
authors.forename: Baharan
authors.initials: B
authors.lastname: Mirzasoleiman
authors.forename: Mahdi
authors.initials: M
authors.lastname: Jalili
mesh_terms: D020816:Amino Acid Motifs; D006801:Humans; D009415:Nerve Net / Q000502:physiology*; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins