title: Electrochemical aptasensor for detection of copper based on a reagentless signal-on architecture and amplification by gold nanoparticles.
abstract: A highly sensitive and specific electrochemical aptasensor for Cu(2+) detection based on gold nanoparticles (AuNPs) is presented. In this work, AuNPs offered a big surface area to immobilize a large number of aptamers and excellent electrochemical signal transduction. Its high sensitivity, low detection limit, and wide detection range are the main advantages over our former copper aptasensor. The peak current increased proportionally to the Cu(2+) concentration over the range from 0.1 nM to 10 μM with a detection limit of 0.1 pM. The presence of other divalent metal ions did not affect the detection of Cu(2+), which indicates a high specificity of Cu(2+) detection could be detected. Rapidity, simplicity, and excellent selectivity make it suitable for practical use in determination of Cu(2+) from lake samples.
authors.affiliation: School of Chemistry & Environment, Beihang University, Beijing 100191, China.
authors.forename: Zhengbo
authors.initials: Z
authors.lastname: Chen
authors.forename: Lidong
authors.initials: L
authors.lastname: Li
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Mu
authors.forename: Hongtao
authors.initials: H
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
mesh_terms: D052157:Aptamers, Nucleotide; D003300:Copper / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods*; D005618:Fresh Water / Q000032:analysis*; D006046:Gold; D057230:Limit of Detection; D053768:Metal Nanoparticles; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D052157:Aptamers, Nucleotide; D014874:Water Pollutants, Chemical; D006046:Gold; D003300:Copper