title: Postoperative analgesia with tramadol and indomethacin for diagnostic curettage and early termination of pregnancy.
abstract: BACKGROUND
  The postoperative analgesic effects of rectal indomethacin and tramadol were compared in patients undergoing elective termination of first trimester pregnancy and diagnostic dilatation and curettage.
  
  
  METHODS
  Eighty-one American Society of Anesthesiologists class I and II women undergoing first trimester termination of pregnancy or diagnostic dilation and curettage were randomly allocated to receive rectal suppositories of either tramadol 100 mg (n=41) or indomethacin 100 mg (n=40) 90 min before induction of anesthesia. Pain scores and side effects were evaluated until discharge. Intraoperative anesthetic and postoperative analgesic consumption was also recorded. Intravenous metamizole 1 g was employed for postoperative rescue analgesia.
  
  
  RESULTS
  When compared to the indomethacin group, the tramadol group required less intraoperative propofol [136 mg ±28 vs. 160 mg ±35 (P=0.001)], less rescue analgesia [2.4% vs. 22% (P=0.005)] and lower visual analogue pain scores [2.4 ±8 vs. 23 ±22 (P=0.005)]. The incidence of postoperative nausea and vomiting was similar in both groups.
  
  
  CONCLUSIONS
  When compared to indomethacin 100 mg, preoperative administration of tramadol 100 mg provides superior postoperative analgesia with minimal adverse effects.
authors.affiliation: Department of Anesthesia, Edith Wolfson Medical Center, Holon, Affiliated with Sackler Medical School, Tel Aviv University, Israel.
authors.forename: V
authors.initials: V
authors.lastname: Khazin
authors.forename: S
authors.initials: S
authors.lastname: Weitzman
authors.forename: E
authors.initials: E
authors.lastname: Rozenzvit-Podles
authors.forename: T
authors.initials: T
authors.lastname: Ezri
authors.forename: A
authors.initials: A
authors.lastname: Debby
authors.forename: A
authors.initials: A
authors.lastname: Golan
authors.forename: S
authors.initials: S
authors.lastname: Evron
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000768:Anesthesia, General; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004107:Dilatation and Curettage; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D015656:Respiratory Mechanics / Q000187:drug effects; D013488:Suppositories; D014147:Tramadol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013488:Suppositories; D014147:Tramadol; D007213:Indomethacin