title: Copper-glucosamine microcubes: synthesis, characterization, and C-reactive protein detection.
abstract: Cubelike microstructures of glucosamine-functionalized copper (GlcN-CuMC's) have been fabricated by the integration of injection pump and ultrasonochemistry. Although bulk microstructures and the nanostructure of metallic copper exhibit distinct applications, the amino sugar surface-functionalized copper is almost biocompatible and exhibits advanced features such as more crystallinity, high thermal stability, and electrochemical feasibility toward biomolecule (C-reactive protein, CRP) detection. An electrochemical test of this GlcN-CuMC's was demonstrated by immobilization on a conventional gold-PCB (Au-PCB) electrode. The combination of a biointerface membrane, from glucosamine functionalization, and electroactive sites of metallic copper provides a very efficient electrochemical response against various concentration of CRP. A perfect scaling of steady-state currents with r(2) values of 0.9862 (I(pa)) and 0.9972 (I(pc)) indicate the promise of this kind of biofunctionalized microstructure electrode for many surface and interface applications.
authors.affiliation: Department of Bionanotechnology, Kyungwon University, Gyeonggi, Republic of Korea.
authors.forename: Murugan
authors.initials: M
authors.lastname: Veerapandian
authors.forename: Ramesh
authors.initials: R
authors.lastname: Subbiah
authors.forename: Guei-Sam
authors.initials: GS
authors.lastname: Lim
authors.forename: Sung-Ha
authors.initials: SH
authors.lastname: Park
authors.forename: KyuSik
authors.initials: K
authors.lastname: Yun
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Lee
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D002097:C-Reactive Protein / Q000032:analysis*; D003300:Copper / Q000737:chemistry*; D005944:Glucosamine / Q000737:chemistry*; D006801:Humans; D055616:Microtechnology / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D003300:Copper; D002097:C-Reactive Protein; D005944:Glucosamine