title: Effect of Ficus sycomorus and Azadirachta indica extracts on liver state of mice infected with Schistosoma mansoni.
abstract: The potential role of hepatoprotective and antipathological effect of Ficus sycomorus and Azadirachta indica extracts was evaluated for scavenging the reactive oxygen species (ROS) and reduced the oxidative damage and pathological changes in the liver of S. mansoni infected mice. The levels of alanine aminotransferase (ALT), asparate aminotransferase (AST) and gamma glutamyl transferase (GGT) were evaluated in the infected mice and treated orally with each plant extract 12 weeks post infection (P.I.) in a dose of 500 mg/kg of each plant extract for five consecutive days and sacrificed two weeks P.I. The infection of mice showed an elevation of ALT, AST & GGT. Treatment of mice with 70% methanol extract of each plant extract reduced significantly ALT, AST & GGT elevation. The highest reduction was with the methanolic extract of F. sycomorus (42%, 35% &44% for ALT, AST & GGT respectively). Fractionation of the methanolic extract of each plant was carried out. The effect of ethyl acetate and butanolic fractions of each plant was also evaluated. The result showed that the two fractions lowered the levels of the tested enzymes and decreased the number and size of granuloma diameters with an increased in the percentage of degenerated ova.
authors.affiliation: Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Imbaba P.O.B. 30, Giza, Egypt.
authors.forename: Mortada M
authors.initials: MM
authors.lastname: El-Sayed
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Abdel-Hadi
authors.forename: Abdel Nasser A
authors.initials: AN
authors.lastname: Sabra
authors.forename: Maher A
authors.initials: MA
authors.lastname: Mahmoud
authors.forename: Eman A
authors.initials: EA
authors.lastname: El-Wakil
authors.forename: Mosad A
authors.initials: MA
authors.lastname: Ghareeb
mesh_terms: D000818:Animals; D031601:Azadirachta / Q000737:chemistry*; D030681:Ficus / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000469:parasitology*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves; D017382:Reactive Oxygen Species; D012550:Schistosoma mansoni / Q000187:drug effects; D012555:Schistosomiasis mansoni / Q000188:drug therapy*
chemical_list: D016166:Free Radical Scavengers; D010936:Plant Extracts; D017382:Reactive Oxygen Species