title: Is Gilbert syndrome a new risk factor for breast cancer?
abstract: Patients with Gilbert syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis.
authors.affiliation: Medical School, Universidade de São Paulo, Brazil. rafael.astolfi95@gmail.com
authors.forename: Rafael Haddad
authors.initials: RH
authors.lastname: Astolfi
authors.forename: Diogo Diniz Gomes
authors.initials: DD
authors.lastname: Bugano
authors.forename: Alice Aparecida Rodrigues Ferreira
authors.initials: AA
authors.lastname: Francisco
authors.forename: Marcelo Moreira Tavares
authors.initials: MM
authors.lastname: de Souza
authors.forename: Suzane Kioko
authors.initials: SK
authors.lastname: Ono-Nita
authors.forename: Edmund Chada
authors.initials: EC
authors.lastname: Baracat
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology* / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D005878:Gilbert Disease / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors; D000099148:UGT1A1 Enzyme
chemical_list: D004967:Estrogens; D014453:Glucuronosyltransferase; D000099148:UGT1A1 Enzyme