title: Is cytomegalovirus a therapeutic target in glioblastoma?
abstract: Several investigators have now demonstrated the expression of genes unique to cytomegalovirus (CMV) in malignant gliomas. Many of these genes promote oncogenesis, alter tumor microenvironment, and serve as immunologic targets. Is the level of CMV infection within tumor cells sufficient to drive important oncogenic or immunosuppressive processes? Can CMV serve as a target for therapeutic intervention?
authors.affiliation: Duke University Medical Center, Durham, North Carolina 27710, USA. john.sampson@duke.edu
authors.forename: John H
authors.initials: JH
authors.lastname: Sampson
authors.forename: Duane A
authors.initials: DA
authors.lastname: Mitchell
mesh_terms: D001932:Brain Neoplasms / Q000276:immunology* / Q000378:metabolism* / Q000821:virology*; D003587:Cytomegalovirus / Q000276:immunology*; D005909:Glioblastoma / Q000276:immunology* / Q000821:virology*; D006801:Humans; D009000:Monocytes / Q000276:immunology*