title: The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: results from the CALERIE Trial of Human Caloric Restriction.
abstract: Decreasing oxidative stress and increasing antioxidant defense has been hypothesized as one mechanism by which caloric restriction (CR) increases longevity in animals. A total of 46 moderately overweight volunteers (BMI: 25-30 kg/m2), ages 20-42 yr were randomized to either high glycemic (HG) or low glycemic (LG) dietary load CR regimen at either 10% (n=12) or 30% (n=34) of basal caloric intake. All food was provided to participants for 6 mo. Overall, after controlling for CR levels and dietary regimen for 6 mo, plasma glutathione peroxidase activity increased (p=0.04) and plasma protein carbonyl levels decreased (p=0.02) and a non-significant decrease in plasma 8-epi-prostaglandin F2α level was observed (p=0.09). No significant change was observed in other plasma antioxidants such as superoxide dismutase and catalase. These findings indicate that short term CR (10% or 30%) in moderately overweight subjects modulates some but not all measures of antioxidant defense and oxidative stress.
authors.affiliation: USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. mohsen.meydani@tufts.edu
authors.forename: M
authors.initials: M
authors.lastname: Meydani
authors.forename: S
authors.initials: S
authors.lastname: Das
authors.forename: M
authors.initials: M
authors.lastname: Band
authors.forename: S
authors.initials: S
authors.lastname: Epstein
authors.forename: S
authors.initials: S
authors.lastname: Roberts
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D031204:Caloric Restriction / Q000379:methods*; D004032:Diet; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D002149:Energy Intake; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D038321:Glycemic Index; D006801:Humans; D008136:Longevity; D008297:Male; D050177:Overweight / Q000178:diet therapy* / Q000378:metabolism; D018384:Oxidative Stress; D050050:Protein Carbonylation; D055815:Young Adult
chemical_list: D000975:Antioxidants; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D005979:Glutathione Peroxidase