title: Histopathological correlation of squamous cell abnormalities detected on cervical cytology.
abstract: OBJECTIVE
  To investigate the correlation between cytology and cervical biopsy in patients with squamous cell abnormality on cervical cytology.
  
  
  METHODS
  The cervical smears diagnosed in our clinic between 2005-2008 were reviewed retrospectively. Cases which exhibited squamous cell abnormality (n: 374) were evaluated.
  
  
  RESULTS
  The mean age was 45.15±10.78. In the cytopathological results, 256 (68.4%) ASC-US, 21 (5.6%) ASC-H, 31 (8.2%) LSIL, 48 (12.8%) HSIL, and 8 (4.8%) invasive carcinomas were diagnosed. Histopathological results were 213 (57%) nonneoplastic, 85 (22.7%) CIN I, 14 (3.7%) CIN II, 34(9.0%) CIN III and 28 (7.5%) invasive squamous cell carcinomas. Including all squamous cell abnormalities, the sensitivity of the smear test in CIN I and higher grade lesions was 56.95% and the false positivity was 43.04%. Excluding ASC-US and ASC-H lesions, the sensitivity of the smear test was 77.31% and the false positivity was 22.68%. After evaluating cervical cytohistopathological correlation, the positive predictive value was found to be 100% in invasive carcinoma, 62% in HSIL and 38% in LSIL.
  
  
  CONCLUSIONS
  As the grade of cytopathological result increases, the correlation between biopsy and the smear test also increases. The high sensitivity of the cervical smear test for high-grade lesions shows that it is an effective screening test.
authors.affiliation: Department of Obstetrics and Gynaecology Namık Kemal University, Faculty of Medicine, Tekirdağ, Turkey.
authors.forename: Remzi
authors.initials: R
authors.lastname: Abali
authors.forename: Besim Haluk
authors.initials: BH
authors.lastname: Bacanakgıl
authors.forename: Serdar
authors.initials: S
authors.lastname: Celık
authors.forename: Ozlem
authors.initials: O
authors.lastname: Aras
authors.forename: Pelin
authors.initials: P
authors.lastname: Koca
authors.forename: Birtan
authors.initials: B
authors.lastname: Boran
authors.forename: Nevra
authors.initials: N
authors.lastname: Dursun
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis*