title: Oral squamous cell carcinoma: clinicopathological features in patients with and without recurrence.
abstract: OBJECTIVE
  To compare the clinicopathological profile of oral squamous cell carcinoma (OSCC) in groups with and without recurrence.
  
  
  METHODS
  Records of all patients who underwent surgery for primary OSCC at a single institution during 1999 were identified. Patient demographics, lesion site, clinical and pathologic stage, pathologic grading, pattern of invasion, lymphocytic infiltrate, perineural invasion, and treatment and survival data were collected. Descriptive statistics were calculated for each variable and survival was calculated using Kaplan-Meier and Cox models. Patients were divided into 2 groups: with (n = 25) and without (n = 28) recurrence.
  
  
  RESULTS
  Tongue (p = 0.02) and poorly differentiated (p = 0.04) tumors were associated with recurrence. Kaplan-Meier and Cox models revealed tobacco use and the absence of lymphocytic infiltrate to be associated with the poorest survival in recurrent OSCC.
  
  
  CONCLUSIONS
  The tumor site, tobacco use, and pathological features were involved in the recurrence of OSCC and should be taken into account for OSCC treatment and follow-up.
authors.affiliation: Pathology Division and Department of Head and Neck Surgery, National Cancer Institute (INCA), Rio de Janeiro, Brazil.
authors.forename: Danielle Resende
authors.initials: DR
authors.lastname: Camisasca
authors.forename: Marcos Antônio Nunes Costa
authors.initials: MA
authors.lastname: Silami
authors.forename: Júlia
authors.initials: J
authors.lastname: Honorato
authors.forename: Fernando Luiz
authors.initials: FL
authors.lastname: Dias
authors.forename: Paulo Antônio Silvestre
authors.initials: PA
authors.lastname: de Faria
authors.forename: Simone de Queiroz Chaves
authors.initials: Sde Q
authors.lastname: Lourenço
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008499:Medical Records / Q000706:statistics & numerical data; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology; D016016:Proportional Hazards Models; D012307:Risk Factors