title: [Existing problems and strategies in liposome-mediated nucleic acid delivery].
abstract: Liposome-mediated nucleic acid delivery has been a focus recently, but in the course of delivering nucleic acid, some hurdles seriously limit the nucleic acid exerting treatment effect. This review refers to a series of problems such as low blood stability, reticuloendothelial system absorption, the lower targeting of liposome and the restriction of endosomal escape which are suffered in liposome-mediated nucleic acid delivery; and gives a detail introduction of strategies such as PEGylation, ligand modification, photochemical internalization, the application of degradation liposome and membrane-lytic peptide, to overcome those problems.
authors.affiliation: Department of Pharmaceutical Science, Second Military Medical University, Shanghai 200433, China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Zhang
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Chen
mesh_terms: D000818:Animals; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000493:pharmacokinetics*; D012157:Mononuclear Phagocyte System / Q000378:metabolism*; D053758:Nanoparticles; D009696:Nucleic Acids / Q000737:chemistry / Q000493:pharmacokinetics*; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000493:pharmacokinetics; D011108:Polymers / Q000737:chemistry
chemical_list: D008081:Liposomes; D009696:Nucleic Acids; D011108:Polymers; D011092:Polyethylene Glycols