title: 4-Methylpyrazole as a treatment in naturally occurring ethylene glycol intoxication in cats.
abstract: OBJECTIVE
  To describe the clinical experience and therapeutic use of fomepizole (4-methylpyrazole [4-MP]) in 3 cats with naturally occurring ethylene glycol (EG) toxicity.
  
  
  METHODS
  All cats were documented to be EG positive by an ethylene glycol test kit. This report describes the dose of 4-MP used, available clinicopathological data, and clinical progression during hospitalization. All patients survived to discharge.
  
  
  CONCLUSIONS
  IV use of 4-MP at 125 mg/kg as an initial dose and 31.25 mg/kg at 12, 24, and 36 hours is safe and effective for treatment of naturally occurring EG toxicity in cats. Increased HCO₃ concentrations were noted after IV use of 4-MP. This is the first report documenting the successful treatment of naturally occurring EG intoxication in cats with 4-MP.
authors.affiliation: Section of Emergency and Critical Care, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, C339 Veterinary Medical Center, University of Minnesota, St Paul, MN 55108-6192, USA. johns172@umn.edu
authors.forename: Kelly M
authors.initials: KM
authors.lastname: Tart
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Powell
mesh_terms: D000818:Animals; D000931:Antidotes / Q000008:administration & dosage*; D002371:Cat Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D002415:Cats; D019855:Ethylene Glycol / Q000506:poisoning*; D005260:Female; D000077604:Fomepizole; D008297:Male; D011720:Pyrazoles / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000931:Antidotes; D011720:Pyrazoles; D000077604:Fomepizole; D019855:Ethylene Glycol