title: New candidaspongiolides, tedanolide analogues that selectively inhibit melanoma cell growth.
abstract: Extracts of the sponge genus Candidaspongia showed selective cytotoxicity toward melanoma cells in the NCI 60-cell-line screen. Continued investigation of the Candidaspongia sp. extracts led to the isolation of three new tedanolide analogues, precandidaspongiolides A (1) and B (2) and candidaspongiolide B (4), as well as candidaspongiolide A (3) and tedanolide (5). Semisynthetic derivatives were also generated to develop SAR. Candidaspongiolides A/B were the most potent and showed low nanomolar activity against several melanoma cell lines.
authors.affiliation: Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA.
authors.forename: Emily L
authors.initials: EL
authors.lastname: Whitson
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Pluchino
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Hall
authors.forename: James B
authors.initials: JB
authors.lastname: McMahon
authors.forename: Tawnya C
authors.initials: TC
authors.lastname: McKee
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D008545:Melanoma / Q000473:pathology*; D013329:Structure-Activity Relationship
chemical_list: D018942:Macrolides; C531429:candidaspongiolide; C119775:tedanolide