title: Synthesis and hydroamination catalysis with 3-aryl substituted pyrrolyl and dipyrrolylmethane titanium(IV) complexes.
abstract: Using an iridium-catalyzed borylation/Suzuki-Miyaura coupling sequence several 3-aryl-pyrroles were accessed; in addition, dipyrrolylmethanes incorporating these 3-arylpyrroles were synthesized. Using the monodentate pyrrolyls, Ti(NMe(2))(2)(HNMe(2))(pyr(3,5-CF3))(2) (1) and a 2,4-diarylpyrrolyl complex Ti(NMe(2))(3)(pyr(Ar/Ar')) (2) were prepared and structurally characterized. Titanium species bearing the new dipyrrolylmethane ligands Ti(NMe(2))(2)(NHMe(2))(dpm(3,5-CF3)) (3) and Ti(NMe(2))(2)(NHMe(2))(dpm(F3)) (4) were also generated. Kinetics under pseudo-first order conditions with 3 and 4 showed them to be measurably more active than the parent derivative without the electron-withdrawing aryl groups.
authors.affiliation: Michigan State University, Department of Chemistry, East Lansing, MI 48824, USA.
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Swartz
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Staples
authors.forename: Aaron L
authors.initials: AL
authors.lastname: Odom