title: Baseline new bone formation does not predict bone loss in ankylosing spondylitis as assessed by quantitative computed tomography (QCT): 10-year follow-up.
abstract: BACKGROUND
  To evaluate the relationship between bone loss and new bone formation in ankylosing spondylitis (AS) using 10-year X-ray, dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT) follow-up.
  
  
  METHODS
  Fifteen AS patients free from medical conditions and drugs affecting bone metabolism underwent X-ray, DXA and QCT in 1999 and 2009.
  
  
  RESULTS
  In spine QCT a statistically significant (p = 0,001) decrease of trabecular bone mineral content (BMC) was observed (change ± SD: 18.0 ± 7.3 mg/cm3). In contrast, spine DXA revealed a significant increase of bone mineral density (change ± SD: -0.15 ± 0.14 g/cm2). The mean BMC, both at baseline and follow-up was significantly lower (p = 0.02 and p = 0.005, respectively) in advanced radiological group as compared to early radiological group. However, in multiple regression model after adjustment for baseline BMC, the baseline radiological scoring did not influence the progression of bone loss as assessed with QCT (p = 0.22, p for BMC*X-ray syndesmophyte scoring interaction = 0.65, p for ANOVA-based X-ray syndesmophyte scoring*time interaction = 0.39). Baseline BMC was the only significant determinant of 10-year BMC change, to date the longest QCT follow-up data in AS.
  
  
  CONCLUSIONS
  In AS patients who were not using antiosteoporotic therapy spine trabecular bone density evaluated by QCT decreased over 10-year follow-up and was not related to baseline radiological severity of spine involvement.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine and Gerontology, Jagiellonian University, Sniadeckich, Krakow, Poland. mariuszk@mp.pl
authors.forename: Mariusz
authors.initials: M
authors.lastname: Korkosz
authors.forename: Jerzy
authors.initials: J
authors.lastname: Gąsowski
authors.forename: Piotr
authors.initials: P
authors.lastname: Grzanka
authors.forename: Janusz
authors.initials: J
authors.lastname: Gorczowski
authors.forename: Wojciech
authors.initials: W
authors.lastname: Pluskiewicz
authors.forename: Sławomir
authors.initials: S
authors.lastname: Jeka
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grodzicki
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000704:Analysis of Variance; D015519:Bone Density; D001861:Bone Regeneration; D005500:Follow-Up Studies; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D011044:Poland; D012720:Severity of Illness Index; D013131:Spine / Q000000981:diagnostic imaging* / Q000503:physiopathology; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed