title: Cholesterol-rich low density lipoproteins are also more oxidized.
abstract: Cardiovascular diseases are accompanied by active oxygen species and organic free radical generation. The aim of this study was to examine the possibility of using oxidized low-density lipoprotein (oxLDL) as a new diagnostic biomarker. Epidemiological study in populations of Estonia (782 subjects) and Russia (1433 subjects) was carried out in 2007-2009. The screening procedure included standard epidemiological methods. Oxidative stress was assessed by measuring the level of oxLDL using immunoassay method. Positive correlation between the levels of oxLDL and LDL cholesterol was indicated in blood of patients from estonian (r = 0.61; P < 0.05) and russian (r = 0.56; P < 0.05) populations. In russian population oxLDL/HDL cholesterol ratio was higher in the groups with highest risk of atherosclerosis development or manifest coronary artery disease (CAD). Cholesterol-rich low density lipoproteins are also more oxidized. Estimation of oxLDL/HDL ratio may be used as an independent biochemical marker for atherosclerosis.
authors.affiliation: Russian Cardiology Research Complex, 3rd Cherepkovskaya 15A, Moscow, Russia. lankin@cardio.ru
authors.forename: Vadim
authors.initials: V
authors.lastname: Lankin
authors.forename: Margus
authors.initials: M
authors.lastname: Viigimaa
authors.forename: Alla
authors.initials: A
authors.lastname: Tikhaze
authors.forename: Elena
authors.initials: E
authors.lastname: Kumskova
authors.forename: Galina
authors.initials: G
authors.lastname: Konovalova
authors.forename: Jelena
authors.initials: J
authors.lastname: Abina
authors.forename: Galina
authors.initials: G
authors.lastname: Zemtsovskaya
authors.forename: Tatyana
authors.initials: T
authors.lastname: Kotkina
authors.forename: Elena
authors.initials: E
authors.lastname: Yanushevskaya
authors.forename: Tatyana
authors.initials: T
authors.lastname: Vlasik
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein