title: Effects of acetazolamide on epileptic apnea in migrating partial seizures in infancy.
abstract: We report two cases of migrating partial seizures in infancy complicated with intractable epileptic apnea with severe desaturation. Ictal electroencephalography revealed migrating foci of epileptiform discharges, which spread to bilateral temporal areas resulting in the onset of apnea. Magnetoencephalography detected dipole sources at bilateral perisylvian areas. Single photon emission tomography revealed a significant ictal change in perfusion at bilateral anterior temporal lobes in one patient. Addition of acetazolamide to the regimen resulted in complete disappearance of epileptic seizures.
authors.affiliation: Department of Child Neurology, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaita, Tokyo 187-8551, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Irahara
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Saito
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugai
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Saito
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Komaki
authors.forename: Shin
authors.initials: S
authors.lastname: Nabatame
authors.forename: Yuu
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Mamiko
authors.initials: M
authors.lastname: Hotate
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D001049:Apnea / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000927:Anticonvulsants; D000086:Acetazolamide