title: Performance and longevity of a novel intraosseous device in a goat (Capra hircus) model.
abstract: We performed 2 studies to assess the function and longevity of a novel intraosseous catheter device. For study 1, 9 goats were assigned to 3 groups (intraosseous catheter in the proximal humerus, intraosseous catheter in the proximal tibia, or standard jugular catheter). Devices in the tibia remained in place for less time than did those in the humerus, and no goats exhibited radiographic evidence of resulting damage or structural change in surrounding bone. Positive bacterial cultures were found in all 9 goats at various time points. In study 2, 18 goats were assigned to 2 groups (intraosseous catheter in the wing of the ilium or proximal humerus). Samples for serial aerobic and anaerobic blood cultures and CBC were collected while devices remained in use. Clinical monitoring and removal criteria were identical those for study 1. Catheters in the ilium remained in place for less than 24 h on average, and those in the humerus remained in place for an average of 2.5 d. Several goats with proximal humeral catheters demonstrated moderate lameness after removal, and radiographic evidence of periosteal bone growth was noted in another goat. Bloodwork indicated mild elevations of WBC counts from baseline in some cases. Bacterial growth was found in samples from 4 of 18 goats at various time points. Our study indicated that intraosseous catheters may remain safely in place for more than 24 h, but animals should be monitored closely for negative side effects for several days after removal.
authors.affiliation: Comparative Medicine Program, Veterinary Medical Park, Texas A&M University, College Station, Texas, USA. erin.jackson@utsouthwestern.edu
authors.forename: Erin E
authors.initials: EE
authors.lastname: Jackson
authors.forename: T Clay
authors.initials: TC
authors.lastname: Ashley
authors.forename: Karen F
authors.initials: KF
authors.lastname: Snowden
authors.forename: Vincent C
authors.initials: VC
authors.lastname: Gresham
authors.forename: Christine M
authors.initials: CM
authors.lastname: Budke
authors.forename: Bunita M
authors.initials: BM
authors.lastname: Eichelberger
authors.forename: Destiny A
authors.initials: DA
authors.lastname: Taylor
mesh_terms: D000818:Animals; D000830:Animals, Laboratory / Q000382:microbiology / Q000502:physiology*; D001407:Bacillus / Q000302:isolation & purification; D057785:Catheters / Q000382:microbiology* / Q000592:standards; D004869:Equipment Safety / Q000592:standards*; D015511:Goat Diseases / Q000453:epidemiology* / Q000382:microbiology; D006041:Goats / Q000382:microbiology / Q000502:physiology*; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology / Q000662:veterinary*; D006811:Humerus; D015994:Incidence; D017148:Infusions, Intraosseous / Q000295:instrumentation*; D007601:Jugular Veins; D023421:Models, Animal; D013977:Tibia