title: Hypothyroidism in the elderly: diagnostic pitfalls illustrated by a case report.
abstract: A diagnosis of hypothyroidism in the elderly can easily be overlooked if we rely exclusively on its clinical presentation because this may be highly non-specific, since the signs and symptoms of the disease are common to other diseases typical of old age, and even to the normal aging process. Imaging diagnostics (ultrasound or CT), when considered alone, are also of little use for the purpose of clarifying thyroid gland function. We report here on a case of primary hypothyroidism that was diagnosed late because the correlated signs and symptoms (asthenia, bradycardia, pleural effusions, hyponatremia, worsening renal and respiratory insufficiency, hoarseness) had previously been attributed to the normal aging process and to the patient's other health conditions (Parkinson's disease, PD; chronic obstructive pulmonary disease, COPD). After a couple of weeks of treatment with levothyroxine and liothyronine, there were clinical and laboratory evidences of an improvement in the patient's condition. She became more reactive, with a shriller voice. The pleural effusion disappeared, and so did the bradycardia. Laboratory tests showed normal sodium levels, and the renal insufficiency had improved. The lack of specificity of the clinical presentation of hypothyroidism in the elderly might justify the routine measurement of thyroid-stimulating hormone in these patients.
authors.affiliation: Department of Medicine and Surgical Sciences, Geriatrics Division, University of Padua, Via Giustiniani 2, 35128 Padova, Italy. monica.maselli@unipd.it
authors.forename: Monica
authors.initials: M
authors.lastname: Maselli
authors.forename: Eminè Meral
authors.initials: EM
authors.lastname: Inelmen
authors.forename: Valter
authors.initials: V
authors.lastname: Giantin
authors.forename: Enzo
authors.initials: E
authors.lastname: Manzato
mesh_terms: D000369:Aged, 80 and over; D001919:Bradycardia / Q000175:diagnosis / Q000188:drug therapy; D003951:Diagnostic Errors; D005260:Female; D006685:Hoarseness / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000188:drug therapy; D010300:Parkinson Disease / Q000175:diagnosis; D010996:Pleural Effusion / Q000175:diagnosis / Q000188:drug therapy; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis; D051437:Renal Insufficiency / Q000175:diagnosis / Q000188:drug therapy; D012131:Respiratory Insufficiency / Q000175:diagnosis / Q000188:drug therapy; D012964:Sodium / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use; D014284:Triiodothyronine / Q000627:therapeutic use
chemical_list: D014284:Triiodothyronine; D012964:Sodium; D013974:Thyroxine