title: Premature ventricular contractions originating from the left ventricular septum: results of radiofrequency catheter ablation in twenty patients.
abstract: BACKGROUND
  RFCA has been established as an effective and curative therapy for severely symptomatic PVC from the outflow tract in structurally normal hearts. However, it is unknown whether PVCs originating from the left ventricular septum, are effectively eliminated by RFCA. This study aimed to investigate electrophysiologic characteristics and effects of radiofrequency catheter ablation (RFCA) for patients with symptomatic premature ventricular contraction (PVC) originating from the left ventricular septum without including fascicular PVCs.
  
  
  METHODS
  Characteristics of body surface electrocardiogram (ECG) and electrophysiologic recordings endocardiogram in a successful RFCA target were analyzed in 20 patients with symptomatic PVCs originating from the left ventricular septum. RFCA was performed using pace mapping and activation mapping.
  
  
  RESULTS
  The QRS morphology of PVCs originating from the left ventricular septum is similar to that seen in fascicular tachycardia. Most of the PVCs originated from the left septum appears in the form of ventricular parasystole. The incidence of ventricular parasystole was 70%. Sustained ventricular tachycardia was not inducible by electrical stimulation and isoproterenol infusion in all 20 patients, ablation at the site recording the earliest Purkinje potential was not effective in all 20 patients, and Purkinje potentials were not identified at successful sites during point mapping. Sixteen patients were successful with RFCA using pace mapping and activation mapping, 3 failed, and 1 recurrent.
  
  
  CONCLUSIONS
  Although the ECG characteristics of the PVCs arising from the left ventricular septum are similar to that seen in fascicular tachycardia, the electrophysiologic characteristics are different between the two types of PVCs. The distinguishing characteristic of the PVCs is that Purkinje potentials were not present at the site of successful ablation, suggesting a myocardial as opposed to fascicular substrate. RFCA is an effective curative therapy for symptomatic PVCs originating from the left ventricular septum (not from the left anterior and posterior fascicle).
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jia
authors.forename: Li
authors.initials: L
authors.lastname: Yue-Chun
authors.forename: Ji
authors.initials: J
authors.lastname: Kang-Ting
authors.forename: Zhou
authors.initials: Z
authors.lastname: Na-Dan
authors.forename: Lin
authors.initials: L
authors.lastname: Jia-Xuan
authors.forename: Zhang
authors.initials: Z
authors.lastname: Wen-Wu
authors.forename: Yang
authors.initials: Y
authors.lastname: Peng-Lin
authors.forename: Tang
authors.initials: T
authors.lastname: Ji-Fei
authors.forename: Lin
authors.initials: L
authors.lastname: Jia-Feng
mesh_terms: D000200:Action Potentials; D000293:Adolescent; D000318:Adrenergic beta-Agonists; D000328:Adult; D000368:Aged; D018780:Body Surface Potential Mapping; D017115:Catheter Ablation; D002681:China; D015716:Electrocardiography, Ambulatory; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006801:Humans; D007545:Isoproterenol; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011690:Purkinje Fibers / Q000503:physiopathology; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome; D018879:Ventricular Premature Complexes / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D054088:Ventricular Septum / Q000503:physiopathology / Q000601:surgery*
chemical_list: D000318:Adrenergic beta-Agonists; D007545:Isoproterenol