title: IVM is an alternative for patients with PCO after failed conventional IVF attempt.
abstract: OBJECTIVE
  To determine if IVM of oocytes from unstimulated cycle is a treatment option for patients who did not deliver after standard IVF-ET.
  
  
  METHODS
  Twenty three women with PCO, thirteen of them with normal cycles and all <35 years old, who failed IVF served as their own control. During the control IVF cycle patients were stimulated with 1730.7 ± 639.5 IU recombinant FSH, a long Buserelin acetate protocol was used and embryo transfer was performed on day 2 or 3 after ICSI. After failed IVF immature oocytes were aspirated transvaginally from antral follicles during spontaneous menstrual cycle. Embryo transfer was performed 2 or 3 days later.
  
  
  RESULTS
  11.4 ± 4.8 mature oocytes and 6.7 ± 3.2 embryos were produced with IVF, which served as the control, compared to 9.7 ± 4.5 mature oocytes and 6.2 ± 3.2 embryos with IVM. There was one clinical pregnancy in the IVF group which did not result in a live birth where as five singleton and one pair of twins with healthy live births and one miscarriage in the IVM group.
  
  
  CONCLUSIONS
  IVM does not involve ovarian stimulation with possible financial and health consequences. İt may be an useful treatment after unsuccessful IVF.
authors.affiliation: Department of Obstetrics & Gynecology, School of Medicine, Dokuz Eylul University Hospital, Izmir, Turkey. bulent.gulekli@deu.edu.tr
authors.forename: Bulent
authors.initials: B
authors.lastname: Gulekli
authors.forename: Muge
authors.initials: M
authors.lastname: Kovali
authors.forename: Fulya
authors.initials: F
authors.lastname: Aydiner
authors.forename: Sule
authors.initials: S
authors.lastname: Dogan
authors.forename: Seda S
authors.initials: SS
authors.lastname: Dogan
mesh_terms: D000328:Adult; D002064:Buserelin / Q000627:therapeutic use; D004624:Embryo Transfer / Q000379:methods; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques / Q000379:methods*; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D009865:Oocytes / Q000254:growth & development*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*
chemical_list: D005640:Follicle Stimulating Hormone; D002064:Buserelin