title: Self-reported sleep apnoea and mortality in patients from the Swedish Obese Subjects study.
abstract: Sleep apnoea is associated with increased mortality in sleep clinic and community population groups. It is unclear whether a clinical report of sleep apnoea results in additional mortality risk in patients with severe obesity. The Swedish Obese Subjects (SOS) study is a nonrandomised controlled trial of bariatric surgery versus conventional treatment for the treatment of severe obesity and its complications (mean ± SD body mass index 41 ± 5 kg · m(-2)). The presence or absence of sleep apnoea (witnessed pauses in breathing) was determined by self-reporting at baseline in 3,953 patients who were observed for 54,236 person-yrs (mean 13.5 maximum 21.0 yrs). Sleep apnoea was reported by 934 (23.6%) patients at baseline and was a significant univariate predictor of mortality (hazard ratio (95% CI) 1.74 (1.40-2.18)). In a range of multivariate models of mortality risk, controlling for ≤ 16 other potential confounders and established mortality risk factors, sleep apnoea remained a significant prognostic factor (fully adjusted model 1.29 (1.01-1.65)). Self-reported sleep apnoea is an independent prognostic marker of all-cause mortality in obese patients.
authors.affiliation: National Health and Medical Research Council Centre for Integrated Research and Understanding of Sleep,Woolcock Institute of Medical Research, Sydney School of Medicine, University of Sydney, Sydney, Australia. nmarshall@woolcock.org.au
authors.forename: N S
authors.initials: NS
authors.lastname: Marshall
authors.forename: L
authors.initials: L
authors.lastname: Delling
authors.forename: R R
authors.initials: RR
authors.lastname: Grunstein
authors.forename: M
authors.initials: M
authors.lastname: Peltonen
authors.forename: C D
authors.initials: CD
authors.lastname: Sjöström
authors.forename: K
authors.initials: K
authors.lastname: Karason
authors.forename: L M S
authors.initials: LM
authors.lastname: Carlsson
authors.forename: J
authors.initials: J
authors.lastname: Hedner
authors.forename: K
authors.initials: K
authors.lastname: Stenlöf
authors.forename: L
authors.initials: L
authors.lastname: Sjöström
mesh_terms: D000328:Adult; D050110:Bariatric Surgery / Q000379:methods / Q000401:mortality; D018849:Controlled Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000401:mortality* / Q000601:surgery / Q000628:therapy; D011379:Prognosis; D057566:Self Report; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000401:mortality*; D013548:Sweden / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data