title: Exploiting MeSH indexing in MEDLINE to generate a data set for word sense disambiguation.
abstract: BACKGROUND
  Evaluation of Word Sense Disambiguation (WSD) methods in the biomedical domain is difficult because the available resources are either too small or too focused on specific types of entities (e.g. diseases or genes). We present a method that can be used to automatically develop a WSD test collection using the Unified Medical Language System (UMLS) Metathesaurus and the manual MeSH indexing of MEDLINE. We demonstrate the use of this method by developing such a data set, called MSH WSD.
  
  
  METHODS
  In our method, the Metathesaurus is first screened to identify ambiguous terms whose possible senses consist of two or more MeSH headings. We then use each ambiguous term and its corresponding MeSH heading to extract MEDLINE citations where the term and only one of the MeSH headings co-occur. The term found in the MEDLINE citation is automatically assigned the UMLS CUI linked to the MeSH heading. Each instance has been assigned a UMLS Concept Unique Identifier (CUI). We compare the characteristics of the MSH WSD data set to the previously existing NLM WSD data set.
  
  
  RESULTS
  The resulting MSH WSD data set consists of 106 ambiguous abbreviations, 88 ambiguous terms and 9 which are a combination of both, for a total of 203 ambiguous entities. For each ambiguous term/abbreviation, the data set contains a maximum of 100 instances per sense obtained from MEDLINE.We evaluated the reliability of the MSH WSD data set using existing knowledge-based methods and compared their performance to that of the results previously obtained by these algorithms on the pre-existing data set, NLM WSD. We show that the knowledge-based methods achieve different results but keep their relative performance except for the Journal Descriptor Indexing (JDI) method, whose performance is below the other methods.
  
  
  CONCLUSIONS
  The MSH WSD data set allows the evaluation of WSD algorithms in the biomedical domain. Compared to previously existing data sets, MSH WSD contains a larger number of biomedical terms/abbreviations and covers the largest set of UMLS Semantic Types. Furthermore, the MSH WSD data set has been generated automatically reusing already existing annotations and, therefore, can be regenerated from subsequent UMLS versions.
authors.affiliation: National Library of Medicine, Bethesda, MD 20894, USA. antonio.jimeno@gmail.com
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Jimeno-Yepes
authors.forename: Bridget T
authors.initials: BT
authors.lastname: McInnes
authors.forename: Alan R
authors.initials: AR
authors.lastname: Aronson
mesh_terms: D000043:Abstracting and Indexing; D000465:Algorithms; D006801:Humans; D051188:Knowledge Bases; D016239:MEDLINE; D046650:Medical Subject Headings; D009323:Natural Language Processing; D012660:Semantics; D017432:Unified Medical Language System; D014481:United States