title: Nanomaterials for X-ray imaging: gold nanoparticle enhancement of X-ray scatter imaging of hepatocellular carcinoma.
abstract: We present the development of a new imaging technique for the early diagnosis of hepatocellular carcinoma that utilizes surface-modified gold nanoparticles in combination with X-ray imaging. Tissues labeled with these electron-dense particles show enhanced X-ray scattering over normal tissues, distinguishing cells containing gold nanoparticles from cells without gold in X-ray scatter images. Our results suggest that this novel approach could enable the in vivo detection of tumors as small as a few millimeters in size.
authors.affiliation: Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States.
authors.forename: Danielle
authors.initials: D
authors.lastname: Rand
authors.forename: Vivian
authors.initials: V
authors.lastname: Ortiz
authors.forename: Yanan
authors.initials: Y
authors.lastname: Liu
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Derdak
authors.forename: Jack R
authors.initials: JR
authors.lastname: Wands
authors.forename: Milan
authors.initials: M
authors.lastname: Tatíček
authors.forename: Christoph
authors.initials: C
authors.lastname: Rose-Petruck
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*; D057054:Molecular Imaging; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D010316:Particle Size; D012542:Scattering, Radiation; D013499:Surface Properties; D014965:X-Rays
chemical_list: D006046:Gold