title: Pulmonary arterial hypertension and benfluorex: 5 case reports.
abstract: Benfluorex, an amphetamine derivative, was marketed as an adjunctive drug for patients with hypertriglyceridemia or diabetes with overweight. We describe here 5 cases of pulmonary arterial hypertension (PAH) associated to a treatment with this drug and notified to the Midi-Pyrénées Pharmacovigilance Centre. All cases are women, exposed to benfluorex during at least 3 years. In most of cases, benfluorex was used off-licence, for overweight.
authors.affiliation: Université de Toulouse, Toulouse, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Bondon-Guitton
authors.forename: Grégoire
authors.initials: G
authors.lastname: Prévôt
authors.forename: Alain
authors.initials: A
authors.lastname: Didier
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montastruc
mesh_terms: D000328:Adult; D000368:Aged; D001067:Appetite Depressants / Q000009:adverse effects*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D004110:Diltiazem / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004417:Dyspnea / Q000139:chemically induced; D065627:Familial Primary Pulmonary Hypertension; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000628:therapy; D000960:Hypolipidemic Agents / Q000009:adverse effects*; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000601:surgery; D009765:Obesity / Q000150:complications / Q000188:drug therapy; D010100:Oxygen / Q000627:therapeutic use; D012891:Sleep Apnea Syndromes / Q000150:complications
chemical_list: D001067:Appetite Depressants; D002121:Calcium Channel Blockers; D004232:Diuretics; D000960:Hypolipidemic Agents; D005277:Fenfluramine; C001584:benfluorex; D005665:Furosemide; D004110:Diltiazem; D010100:Oxygen