title: [Fetoscopic laser coagulation in 100 consecutive monochorionic pregnancies with severe twin-to-twin transfusion syndrome].
abstract: OBJECTIVE
  To report pre- and post-surgical datas of large series of severe twin-to-twin transfusion syndrome (TTTS) managed with laser ablation surgery in our centre, to evaluate the incidence of complications, perinatal outcome and to compare with other cohorts.
  
  
  METHODS
  Observational study of 100 cases of TTTS consecutively treated with fetoscopic laser coagulation between January 2004 and April 2010 in CMCO-SIHCUS of Schiltigheim.
  
  
  RESULTS
  There are nine stage I, 49 stage II, 38 stage III and four stage 4. Median gestation at time of laser is 20.6 weeks (14-29) whereas median gestation at delivery is 32.6 weeks (16.3-39). Overall perinatal survival rate is 68.5% (137 children over 200). Eighty-five percent have one or more surviving twins. The survival rate is the same for donors and for recipients. Preterm premature rupture of the membranes are observed in 17% of cases and the median gestational age for this complication is 30 weeks (20-34). Cerebral abnormalities are present in 7% of newborns.
  
  
  CONCLUSIONS
  Our results for the management of severe TTTS are comparable to the other reported series. There are still many questions remaining concerning the optimal management of TTTS.
authors.affiliation: Département d'échographie et de médecine fœtale, pôle de gynécologie obstétrique, CMCO-SIHCUS, 19 rue Louis-Pasteur, Schiltigheim, France. Anne-Sophie.Weingertner@sihcus.fr
authors.forename: A-S
authors.initials: AS
authors.lastname: Weingertner
authors.forename: A
authors.initials: A
authors.lastname: Kohler
authors.forename: C
authors.initials: C
authors.lastname: Mager
authors.forename: C
authors.initials: C
authors.lastname: Miry
authors.forename: B
authors.initials: B
authors.lastname: Viville
authors.forename: M
authors.initials: M
authors.lastname: Kohler
authors.forename: M-C
authors.initials: MC
authors.lastname: Hunsinger
authors.forename: F
authors.initials: F
authors.lastname: Hornecker
authors.forename: N
authors.initials: N
authors.lastname: Bouffet
authors.forename: S
authors.initials: S
authors.lastname: Trastour
authors.forename: M
authors.initials: M
authors.lastname: Neumann
authors.forename: F
authors.initials: F
authors.lastname: Roth
authors.forename: C
authors.initials: C
authors.lastname: Bartolomei
authors.forename: R
authors.initials: R
authors.lastname: Favre
mesh_terms: D000328:Adult; D001921:Brain / Q000002:abnormalities; D015331:Cohort Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D005330:Fetofetal Transfusion / Q000453:epidemiology / Q000601:surgery*; D005332:Fetoscopy / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D017075:Laser Coagulation / Q000379:methods*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000601:surgery; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012720:Severity of Illness Index; D055815:Young Adult