title: Improved therapeutic effect of folate-decorated PLGA-PEG nanoparticles for endometrial carcinoma.
abstract: Folate (FOL) mediated poly-lactide-co-glycolide-polyethylene glycol nanoparticles (FOL-PEG-PLGA NPs) bearing paclitaxel (PTX) were prepared for the effective delivery of drug to endometrial carcinoma. The average size, zeta potential and encapsulation efficiency of FOL-targeted NPs were found to be around 220 nm, -30.43 mV and 95.6%. Cellular uptake was observed. The accumulation of FOL-targeted NPs depends on dual effects of passive and active targeting. The FOL-targeted PTX NPs showed a greater cytotoxicity against HEC-1A cancer cells in vitro and in vivo, which might be induced by apoptosis. H&E staining did not showed apparent tissue damage to liver and kidney of the mice after injecting NPs intravenously. These results suggest that the novel FOL-PEG-PLGA NPs could be a potential delivery system with excellent therapeutic efficacy for targeting the drugs to cancer cells.
authors.affiliation: Department of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Changyan
authors.initials: C
authors.lastname: Liang
authors.forename: Yuebo
authors.initials: Y
authors.lastname: Yang
authors.forename: You
authors.initials: Y
authors.lastname: Ling
authors.forename: Yueshan
authors.initials: Y
authors.lastname: Huang
authors.forename: Tian
authors.initials: T
authors.lastname: Li
authors.forename: Xiaomao
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D016889:Endometrial Neoplasms / Q000188:drug therapy*; D005260:Female; D005492:Folic Acid / Q000737:chemistry*; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005492:Folic Acid; D017239:Paclitaxel