title: Total synthesis of the cyanolide A aglycon.
abstract: The synthesis of the potent molluscicide cyanolide A has been achieved in 10 steps without the use of protecting groups. The synthesis features a key Sakurai macrocyclization/dimerization reaction that simultaneously forms both tetrahydropyran rings and the macrocycle of the natural product.
authors.affiliation: Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Gesinski
authors.forename: Scott D
authors.initials: SD
authors.lastname: Rychnovsky
mesh_terms: D003500:Cyclization; D019281:Dimerization; D047028:Macrocyclic Compounds / Q000138:chemical synthesis; D018942:Macrolides / Q000138:chemical synthesis*
chemical_list: D047028:Macrocyclic Compounds; D018942:Macrolides; C548188:cyanolide A