title: Perioperative seizure incidence and risk factors in 223 pediatric brain tumor patients without prior seizures.
abstract: OBJECTIVE
  The incidence of, and risk factors for, perioperative seizures and the need for perioperative antiepileptic drugs (AEDs) in previously seizure-free children with brain tumors remains unclear. The authors have undertaken a review of previously seizure-free pediatric patients with brain tumors undergoing resection to identify the incidence of seizures in the perioperative period, and to characterize risk factors for perioperative seizures in this population.
  
  
  METHODS
  A retrospective review was conducted of all patients between 0 and 19 years of age without prior seizures who underwent intracranial tumor resection at the authors' institution between January 2005 and December 2009.
  
  
  RESULTS
  Of the 223 patients undergoing 229 operations, 7.4% experienced at least 1 clinical seizure during the surgical admission. Over half of all tumors were supratentorial. Only 4.4% of patients received prophylactic AEDs. Independent factors associated with perioperative seizures included supratentorial tumor, age < 2 years, and hyponatremia due to syndrome of inappropriate antidiuretic hormone or cerebral salt wasting. Tumor type, lobe affected, operative blood loss, and length of surgery were not independently associated with seizure incidence.
  
  
  CONCLUSIONS
  Perioperative seizures in previously seizure-free children undergoing resection of brain tumors are associated with supratentorial tumor location, age < 2 years, and postoperative hyponatremia. Perioperative seizures are not associated with tumor pathology, tumor size, or frontotemporal location. Due to the low incidence of seizures in this series in patients more than 2 years old with normal serum sodium, the authors recommend that pediatric patients with brain tumors not routinely receive perioperative prophylactic AEDs. However, the role for prophylaxis in patients younger than 2 years of age deserves further study.
authors.affiliation: Department of Neurosurgery, University of Pennsylvania Medical Center, and Division of Neurosurgery, Children's Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104-4399, USA. dharde@mail.med.upenn.edu
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Hardesty
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Sanborn
authors.forename: Whitney E
authors.initials: WE
authors.lastname: Parker
authors.forename: Phillip B
authors.initials: PB
authors.lastname: Storm
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000927:Anticonvulsants / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000150:complications* / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications; D015994:Incidence; D007223:Infant; D008297:Male; D059035:Perioperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D015173:Supratentorial Neoplasms / Q000601:surgery; D055815:Young Adult
chemical_list: D000927:Anticonvulsants