title: Stimulation of defecation in spinal cord-injured rats by a centrally acting ghrelin receptor agonist.
abstract: METHODS
  Animal proof of principle study.
  
  
  OBJECTIVE
  To determine whether capromorelin, a compound that causes defecation by stimulating ghrelin receptors within the lumbosacral defecation centers, is effective after spinal cord injury (SCI), and whether SCI significantly alters sensitivity to the compound.
  
  
  METHODS
  University of Melbourne and Austin Hospital, Melbourne, Australia.
  
  
  METHODS
  Rats were subjected to spinal cord contusion injury or were sham-operated. At 6 weeks after surgery, effects of capromorelin on blood pressure, heart rate and propulsive contractions of the colorectum were investigated.
  
  
  RESULTS
  Capromorelin caused robust propulsive activity in the colorectum soon after its application. The compound was similarly effective in naïve, sham-operated and spinal cord-injured rats. Blood pressure increases caused by capromorelin were not exaggerated after SCI, and there was no evidence of phasic blood pressure increases when the colon was contracted by the compound.
  
  
  CONCLUSIONS
  Capromorelin is a therapeutic compound that could potentially be used to relieve constipation by triggering defecation in spinal cord-injured patients.
authors.affiliation: Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: D M
authors.initials: DM
authors.lastname: Ferens
authors.forename: M D
authors.initials: MD
authors.lastname: Habgood
authors.forename: N R
authors.initials: NR
authors.lastname: Saunders
authors.forename: Y H
authors.initials: YH
authors.lastname: Tan
authors.forename: D J
authors.initials: DJ
authors.lastname: Brown
authors.forename: J A
authors.initials: JA
authors.lastname: Brock
authors.forename: J B
authors.initials: JB
authors.lastname: Furness
mesh_terms: D000818:Animals; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D003672:Defecation / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D013006:Growth Hormone / Q000378:metabolism; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D054440:Receptors, Ghrelin / Q000819:agonists* / Q000502:physiology; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology*
chemical_list: C433143:CP 424391; D010880:Piperidines; D011720:Pyrazoles; D054440:Receptors, Ghrelin; D013006:Growth Hormone