title: Diagnostic value of resistin and visfatin, in comparison with C-reactive protein, procalcitonin and interleukin-6 in neonatal sepsis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the predictive value of resistin and visfatin in neonatal sepsis, and to compare these adipocytokines with C-reactive protein (CRP), procalcitonin and interleukin 6 (IL-6).
  
  
  METHODS
  A total of 62 term or near term infants with sepsis proven by positivity of blood culture, and 43 healthy infants were included in this study.
  
  
  RESULTS
  There were no statistically significant differences between the two groups as regards birthweight and gestational age. White blood cell count (p= 0.039), CRP levels (p=0.01), procalcitonin levels (p=0.01), IL-6 levels (p= 0.01), visfatin levels (p=0.01) and resistin levels (p=0.01) were significantly higher in septic infants. There was a positive correlation between visfatin, resistin and other markers (WBC, CRP, procalcitonin and IL-6). A cut-off value of 10 ng/mL for visfatin, showed 92% sensitivity and 94% specificity, and a cut-off value of 8 ng/mL for resistin showed 93% sensitivity and 95% specificity for neonatal sepsis.
  
  
  CONCLUSIONS
  In the light of these results, visfatin and resistin can be used as a diagnostic marker similar to CRP, procalcitonin and IL-6 in neonatal sepsis. Further studies are needed to better understand the role and predictive value of these molecules in neonatal sepsis.
authors.affiliation: GATA Medical Faculty, Department of Neonatology, Ankara, Turkey.
authors.forename: Ferhat
authors.initials: F
authors.lastname: Cekmez
authors.forename: Fuat Emre
authors.initials: FE
authors.lastname: Canpolat
authors.forename: Merih
authors.initials: M
authors.lastname: Cetinkaya
authors.forename: Seçil
authors.initials: S
authors.lastname: Aydinöz
authors.forename: Gokhan
authors.initials: G
authors.lastname: Aydemir
authors.forename: Ferhan
authors.initials: F
authors.lastname: Karademir
authors.forename: Osman Metin
authors.initials: OM
authors.lastname: Ipcioglu
authors.forename: Serdar Ümit
authors.initials: SÜ
authors.lastname: Sarici
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000175:diagnosis; D015850:Interleukin-6 / Q000097:blood*; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011247:Pregnancy; D011498:Protein Precursors / Q000097:blood*; D052243:Resistin / Q000097:blood*; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis*
chemical_list: C000606589:CALCA protein, human; D015850:Interleukin-6; D011498:Protein Precursors; D052243:Resistin; D002116:Calcitonin; D002097:C-Reactive Protein; D054409:Nicotinamide Phosphoribosyltransferase; D015740:Calcitonin Gene-Related Peptide