title: High blood pressure and obesity increase the risk of abnormal glucose tolerance in young adult african americans.
abstract: Higher prevalence of both hypertension and obesity in African Americans is associated with a disproportionately greater burden of cardiovascular diseases in this ethnic group. The purpose of this study was to examine whether there is an interaction between hypertension and obesity that significantly increases the expression of metabolic risk factors for cardiovascular disease. Four groups of young adult African Americans were recruited based on their weight and blood pressure (BP). The effects of weight and BP on metabolic risk factors were analyzed based on data obtained from 484 patients. Results demonstrated that high BP and obesity were independently associated with increased odds of abnormal glucose tolerance, 1.8- and 2.2-fold, respectively. The coexistence of both high BP and obesity further increased the odds of abnormal glucose tolerance 4-fold. In addition, the geometric mean of homeostasis model assessment, an estimate of insulin resistance, increased by 18% with high BP, 60% with obesity, and 90% with the presence of both high BP and obesity. Although no statistically significant interaction between high BP and obesity was detected, the relationships of both high BP and obesity with metabolic risk factors were clearly additive.
authors.affiliation: Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Huan
authors.forename: Stephanie
authors.initials: S
authors.lastname: DeLoach
authors.forename: Scott W
authors.initials: SW
authors.lastname: Keith
authors.forename: Edward C
authors.initials: EC
authors.lastname: Pequignot
authors.forename: Bonita
authors.initials: B
authors.lastname: Falkner
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use; D015992:Body Mass Index; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000473:pathology*; D009765:Obesity / Q000150:complications* / Q000473:pathology; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D000959:Antihypertensive Agents