title: Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice.
abstract: GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning.
authors.affiliation: Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Taylor
authors.forename: Burkhard
authors.initials: B
authors.lastname: Niewoehner
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeburg
authors.forename: Rolf
authors.initials: R
authors.lastname: Sprengel
authors.forename: J Nicholas P
authors.initials: JN
authors.lastname: Rawlins
authors.forename: David M
authors.initials: DM
authors.lastname: Bannerman
authors.forename: David J
authors.initials: DJ
authors.lastname: Sanderson
mesh_terms: D000818:Animals; D001245:Association Learning / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D003463:Cues; D004192:Discrimination, Psychological / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000235:genetics* / Q000503:physiopathology*; D008570:Memory, Short-Term / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D018091:Receptors, AMPA / Q000172:deficiency*; D013028:Space Perception / Q000502:physiology
chemical_list: D018091:Receptors, AMPA