title: Management in the wound-care center outpatient setting of a diabetic patient with forefoot osteomyelitis using Cerament Bone Void Filler impregnated with vancomycin: off-label use.
abstract: Several nonbiodegradable and biodegradable antibiotic cement delivery systems are available for the delivery of antibiotics for adjunctive therapy in the management of osteomyelitis. A major nonbiodegradable delivery system is polymethylmethacrylate beads. Antibiotics that can be incorporated into this delivery system are limited to the heat-stable antibiotics vancomycin and aminoglycosides, tobramycin being the most popular. Calcium sulfate and hydroxyapatite (Cerament Bone Void Filler) is a unique biocompatible and biodegradable ceramic bone void filler that can successfully deliver heat-stable and heat-unstable antibiotics in musculoskeletal infections. The use of Cerament as antibiotic beads has not been previously reported. An off-label case of diabetic foot osteomyelitis successfully managed with surgical bone resection and vancomycin Cerament antibiotic beads is presented. Subsequent surgery for the bone infection and staged removal of the antibiotic beads was not necessary.
authors.affiliation: Lakeland Regional Medical Center, 5421 S Florida Ave, Lakeland, FL 33813, USA. drkarr@gmail.com
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Karr
mesh_terms: D000553:Ambulatory Care; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002133:Calcium Sulfate / Q000627:therapeutic use; D002516:Ceramics / Q000627:therapeutic use*; D017719:Diabetic Foot / Q000628:therapy*; D017886:Durapatite / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D056687:Off-Label Use; D010019:Osteomyelitis / Q000628:therapy*; D014640:Vancomycin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D014640:Vancomycin; D017886:Durapatite; D002133:Calcium Sulfate