title: Drug interaction leading to prolonged sedation in a postoperative high risk coronary bypass surgery patient.
abstract: Use of midazolam infusion in mechanically ventilated patient is an established practice in critical care. In our case, the use of erythromycin as a prokinetic agent for better tolerance of enteral feeding and paralytic ileus led to an interaction between midazolam and erythromycin, which resulted in prolonged and deeply sedated patient. In a critically ill patient, there is always a possibility of multiple drug interactions. It is important to understand them and they should be considered before starting new medication.
authors.affiliation: Department of Anaesthesiology and Critical Care, CARE Hospital, Nagpur, India.
authors.forename: Shrikant
authors.initials: S
authors.lastname: Bobade
authors.forename: Vinay
authors.initials: V
authors.lastname: Kulkarni
authors.forename: Sudhir
authors.initials: S
authors.lastname: Dhumne
authors.forename: Saurabh
authors.initials: S
authors.lastname: Barde
authors.forename: Jitesh
authors.initials: J
authors.lastname: Chauhan
authors.forename: Avinash
authors.initials: A
authors.lastname: Sharma