title: Expression of P-selectin, von Willebrand and endothelin-1 after carotid artery stenting.
abstract: BACKGROUND
  This study was designed to investigate the impact of carotid artery stenting (CAS) on plasma levels of P-selectin, von Willebrand (vWF) and endothelin-1.
  
  
  METHODS
  Sixty-seven patients who received CAS were divided into group 1 (one stent for a simple lesion, n = 38) and group 2 (two stents for complex lesions, n = 29). The levels of P-selectin, vWF and endothelin-1 were measured before CAS, 1 h, 6h, 24 h and 2 weeks after the stenting.
  
  
  RESULTS
  Sixty-one patients completed one-year follow up. Restenosis was noted in 14 (23 %) patients, among these three (4.8 %) had a restenosis of > 50 % of the vascular lumen. In all patients, the levels of P-selectin, vWF and endothelin-1 increased immediately after CAS (P < 0.05 or < 0.01). The levels of vWF and endothelin-1 in group 2 were higher than in group 1 (P < 0.05 or 0.01). There was no significant difference in P-selectin and endothelin-1 between the restenosis and non-restenosis group (P > 0.05). The 24 h vWF in patients with restenosis were higher than in non-restenosis group (P < 0.05).
  
  
  CONCLUSIONS
  CAS results in a significant increase in plasma P-selectin, vWF and endothelin-1. The post-CAS levels of P-selectin, vWF and endothelin-1 are related to the extent of endothelial injury. Whether they are associated with restenosis 12 months after the treatment requires further investigation.
authors.affiliation: Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong, PR China.
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Xia
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: H-Q
authors.initials: HQ
authors.lastname: Qu
authors.forename: W-D
authors.initials: WD
authors.lastname: Cheng
authors.forename: L-X
authors.initials: LX
authors.lastname: Wang
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D017130:Angioplasty / Q000009:adverse effects / Q000295:instrumentation*; D015415:Biomarkers / Q000097:blood; D016893:Carotid Stenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D016009:Chi-Square Distribution; D002681:China; D019332:Endothelin-1 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D011446:Prospective Studies; D011863:Radioimmunoassay; D012008:Recurrence; D015607:Stents; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015854:Up-Regulation; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D019007:P-Selectin; C546937:SELP protein, human; D014841:von Willebrand Factor