title: Surprising hair analysis results following acute carbofuran intoxication.
abstract: We present two non fatal cases of intoxication with carbofuran (CBF) documented by hair analysis. Carbofuran and 3-hydroxycarbofuran (OHCBF, its main metabolite) hair concentrations were determined using a liquid chromatography-tandem mass spectrometry method. The obtained results were surprising if we consider several hair analyses previously published and based on a theory of the presence of xenobiotic in the only segment that comprised its intake. Among the two intoxication cases, we noticed the presence of CBF and OHCBF in hair segments corresponding to 45 days before, and more than 100 days after, the day of intoxication. Additionally, repeated hair samplings and subsequent analysis revealed a decrease of the carbofuran's concentration during the hair life.
authors.affiliation: Department of Pharmacology and Toxicology, CHU Dupuytren, 87042 Limoges Cedex, France. sylvain.dulaurent@unilim.fr
authors.forename: S
authors.initials: S
authors.lastname: Dulaurent
authors.forename: J M
authors.initials: JM
authors.lastname: Gaulier
authors.forename: K
authors.initials: K
authors.lastname: Zouaoui
authors.forename: C
authors.initials: C
authors.lastname: Moesch
authors.forename: B
authors.initials: B
authors.lastname: François
authors.forename: G
authors.initials: G
authors.lastname: Lachâtre
mesh_terms: D002235:Carbofuran / Q000031:analogs & derivatives* / Q000032:analysis / Q000506:poisoning*; D005500:Follow-Up Studies; D053593:Forensic Toxicology / Q000379:methods*; D005602:France; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007306:Insecticides / Q000032:analysis / Q000506:poisoning; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D013406:Suicide, Attempted; D013997:Time Factors
chemical_list: D007306:Insecticides; C028403:3-hydroxycarbofuran; D002235:Carbofuran