title: Targeting interleukin-1β for pain.
abstract: Interleukin-1β (IL-1β) has been implicated in many inflammatory and autoimmune diseases. Its role in pain, however, is under-appreciated. This may in part be due to the challenges involved in approaching the target from a therapeutic stand point. The scope of this brief review is to understand the direct and indirect roles of IL-1β in contributing to different pain states including inflammatory and neuropathic pain, and discuss approaches to block IL-1β production or IL-1β-receptor interactions.
authors.affiliation: Kareus Therapeutics, Norcross, GA 30071, USA. perlecan@gmail.com
authors.forename: Sivaram
authors.initials: S
authors.lastname: Pillarisetti
mesh_terms: D000818:Animals; D006801:Humans; D053583:Interleukin-1beta / Q000737:chemistry / Q000502:physiology*; D058990:Molecular Targeted Therapy; D059225:Nociception / Q000502:physiology; D010146:Pain / Q000188:drug therapy* / Q000276:immunology; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D053583:Interleukin-1beta; D017472:Receptors, Interleukin-1