title: Non-human leukocyte antigen antibodies reactive with endothelial cells could be involved in early loss of renal allografts.
abstract: Preformed donor-specific human leukocyte antigen (HLA) antibodies have been associated with allograft dysfunction and failure. However, recipients of HLA-identical kidneys can develop acute humoral rejection, implicating putative pathogenic antibodies that are directed against non-HLA antigens. We investigated the presence of endothelial cell-reactive antibodies in 11 patients who experienced early loss of their transplanted kidneys owing to humoral rejection and 1 loss from renal venal thrombosis. We examined the potential efficacy of intravenous immunoglobulin to block the binding of these antibodies, as previously suggested for anti-HLA antibodies.
authors.affiliation: Laboratory of Immunology, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil. cronda51@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: Ronda
authors.forename: S C P
authors.initials: SC
authors.lastname: Borba
authors.forename: S C P
authors.initials: SC
authors.lastname: Ferreira
authors.forename: D
authors.initials: D
authors.lastname: Glotz
authors.forename: L E
authors.initials: LE
authors.lastname: Ianhez
authors.forename: H
authors.initials: H
authors.lastname: Rodrigues
authors.forename: C S
authors.initials: CS
authors.lastname: Viggiani
authors.forename: W
authors.initials: W
authors.lastname: Nahas
authors.forename: E
authors.initials: E
authors.lastname: David-Neto
authors.forename: M C R
authors.initials: MC
authors.lastname: Castro
authors.forename: S R
authors.initials: SR
authors.lastname: David Daisa
authors.forename: J
authors.initials: J
authors.lastname: Kalil
authors.forename: N
authors.initials: N
authors.lastname: Panajotopoulos
mesh_terms: D000906:Antibodies / Q000097:blood*; D001938:Brazil; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D042783:Endothelial Cells / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006084:Graft Rejection / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D056724:Immunity, Humoral; D016756:Immunoglobulins, Intravenous / Q000378:metabolism; D016030:Kidney Transplantation / Q000276:immunology*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D015395:Histocompatibility Antigens Class I; D016756:Immunoglobulins, Intravenous