title: Cytomegalovirus quantification: where to next in optimising patient management?
abstract: BACKGROUND
  Over the years quantification of cytomegalovirus (HCMV) load in blood has become a mainstay of clinical management helping direct deployment of antiviral therapy, assess response to therapy and highlight cases of drug resistance.
  
  
  OBJECTIVE
  The review focuses on a brief historical perspective of HCMV quantification and the ways in which viral load is being used to improve patient management.
  
  
  METHODS
  A review of the published literature and also personal experience at the Royal Free Hospital.
  
  
  RESULTS
  Quantification of HCMV is essential for efficient patient management. The ability to use real time quantitative PCR to drive pre-emptive therapy has improved patient management after transplantation although the threshold viral loads for deployment differ between laboratories. The field would benefit from access to a universal standard for quantification.
  
  
  CONCLUSIONS
  We see that HCMV quantification will continue to be central to delivering individualised patient management and facilitating multicentre trials of new antiviral agents and vaccines in a variety of clinical settings.
authors.affiliation: Centre for Virology, Department of Infection, UCL London, United Kingdom.
authors.forename: Claire
authors.initials: C
authors.lastname: Atkinson
authors.forename: Vincent C
authors.initials: VC
authors.lastname: Emery
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage; D001769:Blood / Q000821:virology*; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000998:Antiviral Agents