title: DPP-IV inhibitor may affect spermatogenesis.
abstract: A 39-year-old physician was diagnosed retrograde ejaculation due to diabetes and treated with amoxapine. This treatment was effective; he could ejaculate. He began receiving DPP-IV inhibitor (Sitagliptin 50 mg, daily), in lieu of insulin injection. Unusual effect on semen quality was occurred following the administration of the drug.
authors.affiliation: Department of Urology, Kyoritsu General Hospital, Japan. Electronic address: hibih@quartz.ocn.ne.jp.
authors.forename: Hatsuki
authors.initials: H
authors.lastname: Hibi
authors.affiliation: Department of Urology, Kyoritsu General Hospital, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ohori
authors.affiliation: Department of Urology, Aichi Medical University, School of Medicine, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000657:Amoxapine / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D004542:Ejaculation / Q000187:drug effects; D006801:Humans; D008297:Male; D014179:Neurotransmitter Uptake Inhibitors / Q000627:therapeutic use; D011719:Pyrazines / Q000009:adverse effects / Q000627:therapeutic use; D055101:Semen Analysis; D000068900:Sitagliptin Phosphate; D013091:Spermatogenesis / Q000187:drug effects*; D014230:Triazoles / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D014179:Neurotransmitter Uptake Inhibitors; D011719:Pyrazines; D014230:Triazoles; D000657:Amoxapine; D000068900:Sitagliptin Phosphate