title: Simian immunodeficiency virus infection in rhesus macaques induces selective tissue specific B cell defects in double positive CD21+CD27+ memory B cells.
abstract: B cell dysfunction represents a central feature in HIV infection and pathogenesis. Our recent studies have shown that peripheral and lymphoid double positive CD21+CD27+ B cells were able to become activated and proliferate at higher rates than other B cell subpopulations. Increased proliferation of tonsillar memory B cells was identified compared to other tissues examined. Here, we demonstrate the decreased proliferation of tonsillar memory (CD21+CD27+) B cells during acute SIV infection also suggests that these cells may play an important role in SIV pathogenesis. Our findings demonstrate that SIV infection may induce selective defective responses in specific tissues, by suppressing memory B cell proliferation in tissues.
authors.affiliation: Division of Microbiology, Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA.
authors.forename: Arpita
authors.initials: A
authors.lastname: Das
authors.forename: Ronald S
authors.initials: RS
authors.lastname: Veazey
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Wang
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Lackner
authors.forename: Huanbin
authors.initials: H
authors.lastname: Xu
authors.forename: Bapi
authors.initials: B
authors.lastname: Pahar
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D049109:Cell Proliferation; D005260:Female; D007156:Immunologic Memory / Q000276:immunology*; D007422:Intestines / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008253:Macaca mulatta; D008297:Male; D014066:Palatine Tonsil / Q000276:immunology; D017464:Receptors, Complement 3d / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000276:immunology*
chemical_list: D017464:Receptors, Complement 3d; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7