title: Periodontitis and blood pressure: the concept of dental hypertension.
abstract: Chronic periodontitis is a common inflammatory disorder that is being contemplated as a risk factor for atherosclerotic complications. Current epidemiological evidence also supports its potential association with increases in blood pressure levels and hypertension prevalence. Furthermore, data from cross-sectional studies suggest that in hypertensive subjects periodontitis may enhance the risk and degree of target organ damage. A possible pathogenetic background of an effect of periodontitis on blood pressure should include the systemic generalization of the local oral inflammation, the role of the host immune response, the direct microbial effect on the vascular system and alterations in endothelial function. Inversely, the concept of hypertension unfavorably affecting periodontal tissues cannot be excluded. The two conditions share multiple common risk factors that should be readily controlled for when assessing a possible association. Thoroughly designed prospective and interventional trials are needed in order to determine the impact of periodontitis on blood pressure regulation and incident hypertension and its integration in the clinical approach of both dental and hypertensive patients.
authors.affiliation: First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, Greece. ktsioufis@hippocratio.gr
authors.forename: Costas
authors.initials: C
authors.lastname: Tsioufis
authors.forename: Alexandros
authors.initials: A
authors.lastname: Kasiakogias
authors.forename: Costas
authors.initials: C
authors.lastname: Thomopoulos
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D007249:Inflammation / Q000150:complications; D018836:Inflammation Mediators / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology; D018384:Oxidative Stress; D010518:Periodontitis / Q000150:complications* / Q000503:physiopathology; D010519:Periodontium / Q000473:pathology; D012307:Risk Factors; D059289:Vascular Stiffness
chemical_list: D018836:Inflammation Mediators