title: The effect of exercise training on the responsiveness of renal resistance arteries in rats.
abstract: Blood flow to several tissues changes during an acute bout of exercise. The kidney is one of the organs that are most affected by exercise-induced blood redistribution. The aim of the present study was to investigate possible exercise-induced vascular reactivity changes in renal resistance arteries in rats. Renal resistance arteries were isolated from rats that underwent 8 weeks of swimming and sedentary control rats, and the arteries were evaluated using wire myography. Similar dilation responses to acetylcholine, bradykinin, adenosine, isoproterenol, and sodium nitroprusside were observed in both groups. The vasoconstrictive agents vasopressin, endothelin-1, potassium chloride, and thromboxane A(2) also induced similar responses in both groups; however, the trained group had an increased constrictive response to norepinephrine compared to the control rats. The results of our study show that renal resistance arteries of trained rats behave differently than conduit-type renal arteries and exhibit an increased contractile response to sympathetic agonists. This finding provides supporting evidence that renal blood flow markedly decreases during exercise in trained individuals.
authors.affiliation: Department of Physiology, Akdeniz University, Antalya, Turkey.
authors.forename: Günnur
authors.initials: G
authors.lastname: Koçer
authors.forename: Oktay
authors.initials: O
authors.lastname: Kuru
authors.forename: Filiz
authors.initials: F
authors.lastname: Gündüz
authors.forename: Zeliha
authors.initials: Z
authors.lastname: Bayram
authors.forename: Sadi
authors.initials: S
authors.lastname: Ozdem
authors.forename: Duygu
authors.initials: D
authors.lastname: Aksoy
authors.forename: Umit Kemal
authors.initials: UK
authors.lastname: Sentürk
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D005260:Female; D009213:Myography; D010805:Physical Conditioning, Animal / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D012077:Renal Artery / Q000187:drug effects / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents