title: Chiral indane skeleton based thiourea catalyzed highly stereoselective cascade Michael-enolation-cyclization reaction.
abstract: An efficient asymmetric cascade reaction catalyzed by a chiral bifunctional indane amine-thiourea catalyst has been developed. From a broad substrate scope, chiral dihydro-2H-pyran complexes that contained two stereogenic centers were obtained in a one-pot manner in good to excellent yields (72-97%) and high to excellent stereoselectivities (92-97% ee).
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Ren
authors.forename: Yaojun
authors.initials: Y
authors.lastname: Gao
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000588:Amines / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000588:Amines; D011714:Pyrans; D013890:Thiourea