title: Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment.
abstract: In the present paper, we investigated the 5HTTLPR and STin2 polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4), the G861C polymorphism (rs6296) of the serotonin receptor 1D beta (HTR1B), the T102C (rs6113) and C516T (rs6305) polymorphisms of the serotonin receptor gene subtype 2A (HTR2A), the DAT UTR, DAT intron 8 and DAT intron 14 of the dopamine transporter gene (SLC6A3), the Val-158-Met (rs4680) polymorphism of the COMT and the silent mutation G1287A (rs5569) in the norepinephrine transporter gene (SLC6A2). We genotyped 41 obsessive-compulsive disorder (OCD) outpatients, classified as good-responders (n=27) and poor-responders (n=14) to treatment with clomipramine according to the Yale Brown Obsessive-Compulsive Scale (YBOCS). Patients who achieved a reduction in symptoms of 40% or more in YBOCS after 14 weeks of treatment were considered good-responders. Genotypes and alleles distribution of the investigated polymorphisms were compared between both groups. We did not find association between the studied polymorphisms and clomipramine response in our sample.
authors.affiliation: Institute and Department of Psychiatry, University of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Karen
authors.initials: K
authors.lastname: Miguita
authors.forename: Quirino
authors.initials: Q
authors.lastname: Cordeiro
authors.forename: Roseli Gedanke
authors.initials: RG
authors.lastname: Shavitt
authors.forename: Eurípedes Constantino
authors.initials: EC
authors.lastname: Miguel
authors.forename: Homero
authors.initials: H
authors.lastname: Vallada
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D002997:Clomipramine / Q000627:therapeutic use*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009154:Mutation; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics*; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000235:genetics*; D011110:Polymorphism, Genetic; D011985:Receptors, Serotonin / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D000929:Antidepressive Agents, Tricyclic; D050483:Dopamine Plasma Membrane Transport Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011985:Receptors, Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D002997:Clomipramine