title: Gastrointestinal stromal tumor with skeletal muscle, adrenal and cardiac metastases: an unusual occurrence.
abstract: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the bowel. It most commonly arises in the stomach, followed by the small intestine, colorectum and the esophagus. It usually spreads to the liver or the peritoneum, with bone and lung metastases being infrequent. Here, we present a case report of GIST behaving in a bizarre way. The patient presented with skeletal muscle metastasis and was initially misdiagnosed as leiomyosarcoma. On follow-up, he developed adrenal metastasis, and later, cardiac metastasis. None of the above unusual sites has previously been reported in literature to our knowledge.
authors.affiliation: Department of Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
authors.forename: Usman
authors.initials: U
authors.lastname: Bashir
authors.forename: Asim
authors.initials: A
authors.lastname: Qureshi
authors.forename: Haseeb A
authors.initials: HA
authors.lastname: Khan
authors.forename: Najam
authors.initials: N
authors.lastname: Uddin
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology / Q000556:secondary*; D046152:Gastrointestinal Stromal Tumors / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000473:pathology / Q000556:secondary*; D018482:Muscle, Skeletal / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000175:diagnosis* / Q000473:pathology; D011860:Radiography, Abdominal; D014057:Tomography, X-Ray Computed