title: Vitamin d status in patients with chronic obstructive pulmonary disease who participate in pulmonary rehabilitation.
abstract: OBJECTIVE
  Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease; however, no study has evaluated the influence of vitamin D status on effects of pulmonary rehabilitation (PR).
  
  
  METHODS
  We studied 311 patients, who participated in a 7-week outpatient PR. Vitamin D status was assessed at entry and examined for association with patient characteristics, dropout from PR, and effect on endurance shuttle walk time.
  
  
  RESULTS
  Vitamin D level 25 nM was seen in 61 (19.6%) of the patients. They were significantly younger, were more frequently on long-term oxygen therapy, had higher body mass index and fat-free mass index, had worse quality of life score, tended to have lower percent predicted value for forced expiratory volume in the first second of expiration, and more frequently were current smokers. They had a 3-time higher risk of dropout from the PR program (P = .003) compared with patients with normal vitamin D status and a poorer improvement in endurance shuttle walk time (P = .03).
  
  
  CONCLUSIONS
  In conclusion, vitamin D deficiency was significantly associated with higher dropout rates from PR, and there was a tendency toward a poorer improvement in endurance shuttle walk time.
authors.affiliation: Department of Cardiology and Respiratory Medicine, University Hospital, Hvidovre, Denmark. Ringbaek@dadlnet.dk
authors.forename: Thomas
authors.initials: T
authors.lastname: Ringbaek
authors.forename: Gerd
authors.initials: G
authors.lastname: Martinez
authors.forename: Amal
authors.initials: A
authors.lastname: Durakovic
authors.forename: Jane
authors.initials: J
authors.lastname: Thøgersen
authors.forename: Anne-Kirsten
authors.initials: AK
authors.lastname: Midjord
authors.forename: Jens-Erik Beck
authors.initials: JE
authors.lastname: Jensen
authors.forename: Peter
authors.initials: P
authors.lastname: Lange
mesh_terms: D000368:Aged; D016001:Confidence Intervals; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume; D006305:Health Status Indicators; D006306:Health Surveys; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010045:Outpatients; D010358:Patient Participation / Q000523:psychology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000523:psychology / Q000534:rehabilitation*; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014797:Vital Capacity; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D