title: Radiofrequency ablation of early breast cancer followed by delayed surgical resection--a promising alternative to breast-conserving surgery.
abstract: To examine the radiofrequency ablation (RFA) reliability in early breast cancer, we performed RFA followed by delayed surgical resection on 41 patients with invasive or non-invasive breast carcinoma less than 2 cm. MRI scans were obtained before ablation and resection. Excised specimens were examined pathologically by haematoxylin-eosin and nicotinamide adenine dinucleotide-diaphorase staining. 40 patients completed 1 RFA session, which was sufficient to achieve complete tumour cell death. Overall complete ablation rate was 87.8% (36/41). There were no treatment-related complications other than that of a superficial burn in 1 case. After RFA, the tumour was no longer enhanced on MRI in 25/26 (96.2%) cases. Residual cancer, which was suspected on MRI in 1 case, was confirmed pathologically. MRI could be an applicable modality to evaluate therapeutic effect. RFA could be an alternate local treatment option to breast-conserving surgery for early breast cancer.
authors.affiliation: Department of Breast Surgery, Hiroshima City Hospital, and Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 7-33 Moto-machi, Naka-ku, Hiroshima 730-8518, Japan. sho_ohtani@hotmail.com
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ohtani
authors.forename: Mariko
authors.initials: M
authors.lastname: Kochi
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Ito
authors.forename: Kenji
authors.initials: K
authors.lastname: Higaki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takada
authors.forename: Hiroo
authors.initials: H
authors.lastname: Matsuura
authors.forename: Naoki
authors.initials: N
authors.lastname: Kagawa
authors.forename: Sakae
authors.initials: S
authors.lastname: Hata
authors.forename: Noriaki
authors.initials: N
authors.lastname: Wada
authors.forename: Kouki
authors.initials: K
authors.lastname: Inai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Imoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Moriya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015412:Mastectomy, Segmental; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D009361:Neoplasm Invasiveness; D010865:Pilot Projects; D013997:Time Factors; D016896:Treatment Outcome