title: Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes.
abstract: A series of chiral pyrrolidinyl-sulfamide derivatives have been identified as efficient bifunctional organocatalysts for the direct Michael addition of cyclohexanone to a wide range of nitroalkenes. The desired Michael adducts were obtained in high chemical yields and excellent stereoselectivities (up to 99/1 dr and 95% ee).
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079, China. jiarongchen2003@yahoo.com.cn
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Fu
authors.forename: You-Quan
authors.initials: YQ
authors.lastname: Zou
authors.forename: Ning-Jie
authors.initials: NJ
authors.lastname: Chang
authors.forename: Jian
authors.initials: J
authors.lastname: Rong
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry*; D015394:Molecular Structure; D009595:Nitroparaffins / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000475:Alkenes; D003512:Cyclohexanones; D009595:Nitroparaffins; D011759:Pyrrolidines; D013449:Sulfonamides; C036468:cyclohexanone