title: Evolutionary crossroads in developmental biology: sea urchins.
abstract: Embryos of the echinoderms, especially those of sea urchins and sea stars, have been studied as model organisms for over 100 years. The simplicity of their early development, and the ease of experimentally perturbing this development, provides an excellent platform for mechanistic studies of cell specification and morphogenesis. As a result, echinoderms have contributed significantly to our understanding of many developmental mechanisms, including those that govern the structure and design of gene regulatory networks, those that direct cell lineage specification, and those that regulate the dynamic morphogenetic events that shape the early embryo.
authors.affiliation: Department of Biology, Duke University, Durham, NC 27708, USA. dmcclay@duke.edu
authors.forename: David R
authors.initials: DR
authors.lastname: McClay
mesh_terms: D000818:Animals; D005075:Biological Evolution; D015509:Developmental Biology / Q000379:methods*; D053263:Gene Regulatory Networks; D012617:Sea Urchins / Q000235:genetics / Q000254:growth & development