title: Antioxidant hispidin derivatives from medicinal mushroom Inonotus hispidus.
abstract: Two natural antioxidants, named inonotusin A (1) and B (2), were isolated from the methanolic extract of the fruit bodies of Inonotus hispidus, together with (E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one (3), hispidin (4) and 3,4-dihydroxybenzaldehyde (5). Their structures were identified by means of extensive NMR and MS data analysis. Compounds 1, 2 and 4 exhibited significant scavenging activity against the 2,20-azinobis(3-ethylbenzhiazoline-6-sulfonate) (ABTS) radical cation. Compound 1 also showed moderate cytotoxicity against a human breast carcinoma cell line (MCF-7) with IC(50) values of 19.6 µM.
authors.affiliation: Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun, Jilin, China.
authors.forename: Li-feng
authors.initials: LF
authors.lastname: Zan
authors.forename: Jian-chun
authors.initials: JC
authors.lastname: Qin
authors.forename: Ya-mei
authors.initials: YM
authors.lastname: Zhang
authors.forename: Yan-hua
authors.initials: YH
authors.lastname: Yao
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Bao
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D000975:Antioxidants; D011753:Pyrones; C561259:inonotusin A; C561260:inonotusin B; C007946:hispidin