title: NF-κB signaling in skeletal muscle health and disease.
abstract: Muscle development, growth, and maintenance require an intricate and timely series of events initiated through a multitude of signaling pathways. The very nature of skeletal muscle requires tremendous plasticity to accommodate the need for anabolism or catabolism, and deregulation of these processes may be a tipping point in the development or progression of various skeletal muscle disorders. Among the relevant signaling pathways, NF-κB has emerged as a critical factor involved in various facets of muscle homeostasis. In this review, we summarize the NF-κB signaling pathway and provide a fresh perspective into the regulation and function of this transcription factor, underlying both the physiological and pathophysiological states of skeletal muscle.
authors.affiliation: Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Peterson
authors.forename: Nadine
authors.initials: N
authors.lastname: Bakkar
authors.forename: Denis C
authors.initials: DC
authors.lastname: Guttridge
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D006801:Humans; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B