title: Strong inhibition of xenografted tumor growth by low-level doses of [(32)P]ATP.
abstract: The ability of a potential human anti-cancer therapeutic agent to inhibit the growth of xenografted tumors in nude mice has been an established and accepted testing method for several decades. The current report shows that a single, low-level intravenous dose of [(32)P]ATP significantly inhibits the growth of established xenografted tumors in nude mice. This inhibitory effect becomes appreciable very rapidly, within only five days post-injection and the low dose demonstrates little or no toxicity in the mice. Surprisingly, a narrow dose window of optimum effectiveness is seen, whereby either decreasing or increasing the [(32)P]ATP dose results in far less growth inhibition. Thus, the intravenous systemic injection of [(32)P]ATP may represent a simple, potent method to target and inhibit primary human tumors and malignant lesions.
authors.affiliation: Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Yulan
authors.initials: Y
authors.lastname: Cheng
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Rachana
authors.initials: R
authors.lastname: Agarwal
authors.forename: Gilbert M
authors.initials: GM
authors.lastname: Green
authors.forename: Ron C
authors.initials: RC
authors.lastname: Mease
authors.forename: Martin G
authors.initials: MG
authors.lastname: Pomper
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Meltzer
authors.forename: John M
authors.initials: JM
authors.lastname: Abraham
mesh_terms: D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D049109:Cell Proliferation / Q000528:radiation effects; D015536:Down-Regulation / Q000528:radiation effects; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D016896:Treatment Outcome; D047368:Tumor Burden / Q000528:radiation effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D010761:Phosphorus Radioisotopes; D000255:Adenosine Triphosphate