title: Uncovering auditory evoked potentials from cochlear implant users with independent component analysis.
abstract: Auditory evoked potentials (AEPs) provide an objective measure of auditory cortical function, but AEPs from cochlear implant (CI) users are contaminated by an electrical artifact. Here, we investigated the effects of electrical artifact attenuation on AEP quality. The ability of independent component analysis (ICA) in attenuating the CI artifact while preserving the AEPs was evaluated. AEPs recovered from CI users were systematically correlated with age, demonstrating that individual differences were well preserved. CI users with high-quality AEPs were characterized by a significantly shorter duration of deafness. Finally, a simulation study revealed very high spatial correlations between original and recovered normal hearing AEPs (r>.95) that were previously contaminated with CI artifacts. The results confirm that after ICA, good quality AEPs can be recovered, facilitating the objective, noninvasive study of auditory cortex function in CI users.
authors.affiliation: Neuropsychology Lab, Department of Psychology, University of Oldenburg, GermanyMRC Institute of Hearing Research, University Park, Nottingham, UKInstitute for Sound and Vibration Research, University of Southampton, UKBiomagnetic Center, Department of Neurology, University Hospital Jena, Jena, Germany.
authors.forename: Filipa C
authors.initials: FC
authors.lastname: Viola
authors.affiliation: Neuropsychology Lab, Department of Psychology, University of Oldenburg, GermanyMRC Institute of Hearing Research, University Park, Nottingham, UKInstitute for Sound and Vibration Research, University of Southampton, UKBiomagnetic Center, Department of Neurology, University Hospital Jena, Jena, Germany.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Thorne
authors.affiliation: Neuropsychology Lab, Department of Psychology, University of Oldenburg, GermanyMRC Institute of Hearing Research, University Park, Nottingham, UKInstitute for Sound and Vibration Research, University of Southampton, UKBiomagnetic Center, Department of Neurology, University Hospital Jena, Jena, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Bleeck
authors.affiliation: Neuropsychology Lab, Department of Psychology, University of Oldenburg, GermanyMRC Institute of Hearing Research, University Park, Nottingham, UKInstitute for Sound and Vibration Research, University of Southampton, UKBiomagnetic Center, Department of Neurology, University Hospital Jena, Jena, Germany.
authors.forename: Julie
authors.initials: J
authors.lastname: Eyles
authors.affiliation: Neuropsychology Lab, Department of Psychology, University of Oldenburg, GermanyMRC Institute of Hearing Research, University Park, Nottingham, UKInstitute for Sound and Vibration Research, University of Southampton, UKBiomagnetic Center, Department of Neurology, University Hospital Jena, Jena, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Debener
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001303:Auditory Cortex / Q000503:physiopathology* / Q000601:surgery; D019929:Cochlear Implantation; D003054:Cochlear Implants; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology