title: [Synthesis of ferulic acid derivatives and their inhibitory effect on platelet aggregation].
abstract: Ferulic acid, an useful compound of Chinese traditional medicine, was used as leading compound. Six ferulic acid derivatives were designed and synthesized based on bioisosterism. Their structures were characterized by IR, 1H NMR, 13C NMR and mass spectra. In vivo experiment showed that ferulic acid derivatives had good inhibitory effects on adenosine diphosphate (ADP) induced platelet aggregation, which were significantly higher than that of Ozagrel.
authors.affiliation: Anhui Key Laboratory of Traditional Chinese Medicine, School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230031, China. lijiaming2004@sina.com
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Li
authors.forename: Yong-Hai
authors.initials: YH
authors.lastname: Zhao
authors.forename: Guo-Chen
authors.initials: GC
authors.lastname: Zhong
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Long
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.forename: Ming
authors.initials: M
authors.lastname: Yuan
mesh_terms: D000818:Animals; D003373:Coumaric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits; D011897:Random Allocation; D013329:Structure-Activity Relationship
chemical_list: D003373:Coumaric Acids; D010975:Platelet Aggregation Inhibitors; C004999:ferulic acid