title: CDH1 promoter polymorphism and stomach cancer susceptibility.
abstract: The relationship of stomach cancer susceptibility and the presence of E-cadherin (CDH1) promoter -160 C/A polymorphism had been reported with conflicting results. To further explore the association of this polymorphism with stomach cancer susceptibility, we performed an extensive search of relevant studies and carried out a meta-analysis to obtain a more precise estimate. A total of 16 studies including 2,611 cases and 3,788 controls were involved in this meta-analysis. When all studies involved, the meta-analysis results suggest no statistically significant association between CDH1 -160 C/A polymorphism and stomach cancer risk (CA vs. CC: OR = 1.01, 95% CI: 0.85-1.19; AA vs. CC: OR = 1.05, 95% CI: 0.75-1.46; dominant model: OR = 1.02, 95% CI: 0.86-1.20; recessive model: OR = 1.04, 95% CI: 0.76-1.41). When subgroup analyses were performed by ethnicity, the A-allele carriers conferred a decreased stomach cancer risk in Asians (AA vs. CC: OR = 0.67, 95% CI: 0.47-0.96; dominant model: OR = 0.85, 95% CI: 0.72-0.99), but no statistically significant association was found in Caucasians. In conclusion, this meta-analysis suggests that CDH1 -160 A-allele may play a protective role of stomach cancer development in Asians but not in Caucasians.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China. lyl-1972@hotmail.com
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Li
authors.forename: Zhong
authors.initials: Z
authors.lastname: Tian
authors.forename: Jian-Bing
authors.initials: JB
authors.lastname: Zhang
authors.forename: Bao-Yu
authors.initials: BY
authors.lastname: Fu
mesh_terms: D015703:Antigens, CD; D044466:Asian People / Q000235:genetics; D015820:Cadherins / Q000235:genetics*; D002681:China / Q000453:epidemiology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016014:Linear Models; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins