title: Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues.
abstract: A series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues were synthesized by the reaction of 5,6-dimethoxy-2-[(E)-1-phenylmethylidene]-1-indanone with hydroxylamine hydrochloride. The title compounds were tested for their in vitro anti-HIV activity. Among the compounds, (4g) showed a promising anti-HIV activity in the in vitro testing against IIIB and ROD strains. The IC50 of both IIIB and ROD were found to be 9.05 microM and > 125 microM, respectively.
authors.affiliation: Pharmacogenetic and Pharmacogenomic Research, Institute for Research in Molecular Medicine, Universiti of Sains Malysia, Pennag-11800, Malaysia. asraf80med@rediffmail.com
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Ali
authors.forename: Rusli
authors.initials: R
authors.lastname: Ismail
authors.forename: Tan S
authors.initials: TS
authors.lastname: Choon
authors.forename: Yeong K
authors.initials: YK
authors.lastname: Yoon
authors.forename: Ang C
authors.initials: AC
authors.lastname: Wei
authors.forename: Suresh
authors.initials: S
authors.lastname: Pandian
authors.forename: Jeyabalan G
authors.initials: JG
authors.lastname: Samy
authors.forename: Eric
authors.initials: E
authors.lastname: De Clercq
authors.forename: Christophe
authors.initials: C
authors.lastname: Pannecouque
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development; D015498:HIV-2 / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D020128:Inhibitory Concentration 50; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D007555:Isoxazoles