title: AICDA expression in BCR/ABL1-positive acute lymphoblastic leukaemia is associated with a peculiar gene expression profile.
abstract: Activation-induced cytidine deaminase (AICDA) initiates somatic hypermutation and class-switch recombination of immunoglobulin (Ig) genes and induces mutations also in non-Ig genes. AICDA aberrant expression was detected in B-lineage acute lymphoblastic leukaemia (B-ALL), particularly BCR/ABL1+ B-ALL; patients expressing AICDA carried more copy number alterations than 'AICDA-negative' cases. To determine the role of AICDA, AICDA expression and gene expression profiling were studied in adult BCR/ABL1+ B-ALL. Patients displaying the full-length isoform AICDA are characterized by up-regulation of DNA repair/replication and cell cycle genes, suggesting their involvement in the genetic instability of BCR/ABL1+ B-ALL.
authors.affiliation: Division of Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome.
authors.forename: Monica
authors.initials: M
authors.lastname: Messina
authors.forename: Sabina
authors.initials: S
authors.lastname: Chiaretti
authors.forename: Ilaria
authors.initials: I
authors.lastname: Iacobucci
authors.forename: Simona
authors.initials: S
authors.lastname: Tavolaro
authors.forename: Annalisa
authors.initials: A
authors.lastname: Lonetti
authors.forename: Simona
authors.initials: S
authors.lastname: Santangelo
authors.forename: Loredana
authors.initials: L
authors.lastname: Elia
authors.forename: Cristina
authors.initials: C
authors.lastname: Papayannidis
authors.forename: Francesca
authors.initials: F
authors.lastname: Paoloni
authors.forename: Antonella
authors.initials: A
authors.lastname: Vitale
authors.forename: Anna
authors.initials: A
authors.lastname: Guarini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
authors.forename: Robin
authors.initials: R
authors.lastname: Foà
mesh_terms: D000328:Adult; D003564:Cytidine Deaminase / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
chemical_list: D016044:Fusion Proteins, bcr-abl; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase