title: Obesity is a risk factor for fracture in children but is protective against fracture in adults: a paradox.
abstract: With the rise in obesity worldwide, an important debate has developed as to whether excess fat has a detrimental or protective effect on skeletal health in children and adults. Obese children appear to be over represented in fracture groups and recent evidence suggests that fat may be detrimental to bone accrual in children, although this effect may be confined to adolescence during rapid skeletal growth. Fat induced alterations in hormonal factors and cytokines during growth may play a pivotal role in disturbing bone accrual. In contrast, the widely accepted opinion is that fat appears to be protective of bone in adults and minimises bone loss in postmenopausal women. Recent evidence suggests that in adults, site specific fat depots may exert differing effects on bone (with visceral fat acting as a pathogenic fat depot and subcutaneous fat exerting protective effects), and that the effects of fat mass on bone and fracture risk may vary by skeletal site; obesity protects against hip and vertebral fractures but is a risk factor for fractures of the humerus and ankle. The incidence of fracture during adolescence is rising and osteoporosis remains a considerable health burden in older adults. Understanding the effects of fat mass on bone during growth and early adulthood is vital in informing future health strategies and pharmacotherapies to optimise peak bone mass and prevent fracture.
authors.affiliation: The NIHR Bone Biomedical Research Unit, Sheffield, UK. pauldimitri@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Dimitri
authors.forename: N
authors.initials: N
authors.lastname: Bishop
authors.forename: J S
authors.initials: JS
authors.lastname: Walsh
authors.forename: R
authors.initials: R
authors.lastname: Eastell
mesh_terms: D050154:Adiposity / Q000502:physiology; D000328:Adult; D001846:Bone Development / Q000502:physiology; D002648:Child; D050723:Fractures, Bone / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D006728:Hormones; D006801:Humans; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D006728:Hormones