title: Association of functionally important polymorphism of microsomal epoxide hydrolase gene (EPHX1) with lung cancer susceptibility.
abstract: Distribution and gene-environment interaction of EPHX1 polymorphism was evaluated in 175 lung cancer patients and 322 controls from north India. Two novel non-synonymous, Lys117Arg and Leu263Phe, and twelve single nucleotide polymorphisms were identified in the present study. Binary logistic regression analysis showed association of polymorphism Tyr113His with increased risk of lung cancer (OR = 2.2, 95% CI = 1.2-4.0, p < .05). Gene-environment interaction revealed that patients with His113His and smoking habit had significantly greater risk of lung cancer (OR = 4.52, 95% CI = 0.93-43.05, p < .05). Present study provided evidence that EPHX1 polymorphism is associated with lung cancer susceptibility in Indian population.
authors.affiliation: Environmental Biotechnology Section, Indian Institute of Toxicology Research (IITR) (Formerly Industrial Toxicology Research Centre), M.G. Marg, Lucknow, Uttar Pradesh, India.
authors.forename: Anup R
authors.initials: AR
authors.lastname: Tilak
authors.forename: Sachin
authors.initials: S
authors.lastname: Kumar
authors.forename: Meenu
authors.initials: M
authors.lastname: Jain
authors.forename: Mohan C
authors.initials: MC
authors.lastname: Pant
authors.forename: Bhudev C
authors.initials: BC
authors.lastname: Das
authors.forename: Randeep
authors.initials: R
authors.lastname: Guleria
authors.forename: Balraj
authors.initials: B
authors.lastname: Mittal
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mathur
authors.forename: Ashwani
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000328:Adult; D000368:Aged; D004851:Epoxide Hydrolases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D016015:Logistic Models; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012907:Smoking / Q000009:adverse effects
chemical_list: D004851:Epoxide Hydrolases; C522330:EPHX1 protein, human