title: Antidepressant-associated mania or hypomania: a comparison with personality and bipolarity features of bipolar I disorder.
abstract: BACKGROUND
  Hypomania/mania during antidepressant treatment is often neglected by clinicians. There are no specific diagnostic criteria for hypomania and mania associated by antidepressant treatment in the bipolar spectrum. The aim of this study is to compare various characteristics of bipolar I disorder and antidepressant-associated mania.
  
  
  METHODS
  In this study, 76 bipolar patients who met DSM-IV criteria for bipolar disorder-type I in remission from mania or depression (Group 1; n = 44) and patients with major depression in remission, who had mania associated by antidepressant treatment (Group 2; n = 32), were admitted. All patients were assessed using the SCID I, Bipolarity Index (BI) and a patient data form. First-degree relatives of all patients were evaluated using the Mood Disorder Questionnaire (MDQ).
  
  
  RESULTS
  Sociodemographic features of both groups were similar. The rate of major depression in the relatives of Group 2 was significantly higher than in Group 1. The severity of manic symptoms in Group 2 was significantly lower than in Group 1. Those in Group 2 who were diagnosed with their first episode had atypical depressive features. First-degree relatives of patients in Group 1 had higher positive scores on the MDQ. A statistically significant difference was found between the two groups on all dimensions of the BI except family history.
  
  
  CONCLUSIONS
  This is a cross-sectional study with a relatively small number of subjects. There is no control group of major depressive patients who did not develop mania during antidepressive treatment.
  
  
  CONCLUSIONS
  Our results suggest that antidepressant-associated hypomania/mania could be a different subgroup in the bipolar spectrum.
authors.affiliation: Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey. osaatcioglu@superonline.com
authors.forename: Omer
authors.initials: O
authors.lastname: Saatcioglu
authors.forename: Rahsan
authors.initials: R
authors.lastname: Erim
authors.forename: Nesrin
authors.initials: N
authors.lastname: Tomruk
authors.forename: Timucin
authors.initials: T
authors.lastname: Oral
authors.forename: Nihat
authors.initials: N
authors.lastname: Alpay
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D003430:Cross-Sectional Studies; D003527:Cyclothymic Disorder / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy; D003863:Depression; D003866:Depressive Disorder / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy; D003865:Major Depressive Disorder / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D010551:Personality; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents