title: The protein kinase CK2 inhibitor TBB mediates up-regulation of MEK3/6 and p38δ activities, down-regulation of ERK1/2 activity and induction of G1/S arrest in normal human epidermal autocrine proliferating keratinocytes.
authors.forename: Antonia Rumenova
authors.initials: AR
authors.lastname: Isaeva
authors.forename: Vanyo Ivanov
authors.initials: VI
authors.lastname: Mitev
mesh_terms: D019898:Autocrine Communication / Q000187:drug effects*; D047390:Casein Kinase II / Q000037:antagonists & inhibitors*; D002453:Cell Cycle / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D015536:Down-Regulation; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects*; D048371:MAP Kinase Kinase 3 / Q000378:metabolism; D048669:MAP Kinase Kinase 6 / Q000378:metabolism; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048292:Mitogen-Activated Protein Kinase 13 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D015854:Up-Regulation
chemical_list: C405354:4,5,6,7-tetrabromobenzotriazole; D047428:Protein Kinase Inhibitors; D014230:Triazoles; D048292:Mitogen-Activated Protein Kinase 13; D047390:Casein Kinase II; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D048371:MAP Kinase Kinase 3; D048669:MAP Kinase Kinase 6