title: Enantioselective binding of a lanthanide(III) complex to human serum albumin studied by 1H STD NMR techniques.
abstract: The enantioselective binding of the (SSS)-Δ isomer of an yttrium(III) tetraazatriphenylene complex to 'drug-site II' of human serum albumin (HSA) was detected by the intensity differences of its STD (1)H NMR spectrum relative to the (RRR)-Λ isomer, by the effect of the competitive binder to that site, N-dansyl sarcosine, upon the STD spectrum of each isomer, in the presence of HSA and by 3D docking simulations.
authors.affiliation: Department of Life Sciences and Center of Neurosciences and Cell Biology, Faculty of Science and Technology, University of Coimbra, P.O. Box 3046, 3001-401 Coimbra, Portugal.
authors.forename: David M
authors.initials: DM
authors.lastname: Dias
authors.forename: João M C
authors.initials: JM
authors.lastname: Teixeira
authors.forename: Ilya
authors.initials: I
authors.lastname: Kuprov
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: New
authors.forename: David
authors.initials: D
authors.lastname: Parker
authors.forename: Carlos F G C
authors.initials: CF
authors.lastname: Geraldes
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D011522:Protons; D011789:Quantum Theory; D012709:Serum Albumin / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; D011522:Protons; D012709:Serum Albumin