title: The cell biology of the unfolded protein response.
abstract: The unfolded protein response (UPR) is an ensemble of signal transduction pathways that respond to perturbations in the oxidative, pro-folding environment of the endoplasmic reticulum. During the past decade, ongoing research implicated these pathways in maintaining homeostasis of cells and organisms exposed to various stresses. Herein, we highlight recent findings regarding the functional role of the UPR in both normal and pathophysiologic processes.
authors.affiliation: The Abramson Family Cancer Research Institute, Department of Cancer Biology, Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. adiehl@mail.med.upenn.edu
authors.forename: J Alan
authors.initials: JA
authors.lastname: Diehl
authors.forename: Serge Y
authors.initials: SY
authors.lastname: Fuchs
authors.forename: Costantinos
authors.initials: C
authors.lastname: Koumenis
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D002453:Cell Cycle; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000821:virology; D004734:Energy Metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D017510:Protein Folding; D015398:Signal Transduction; D013312:Stress, Physiological; D056811:Unfolded Protein Response; D014777:Virus Diseases / Q000378:metabolism