title: A new drimane sesquiterpenoid glycoside from the seeds of Antiaris toxicaria.
abstract: A new drimane sesquiterpenoid glycoside, named 7-drimen-3β,11-diol 3-O-β-d-glucopyranoside, was isolated from the 95% EtOH extract of the seeds of Antiaris toxicaria (Pers.) Lesch. The chemical structure was completely elucidated using a combination of 1D and 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analysis. The compound showed inhibitory activities toward methicillin-resistant Staphylococcus aureus (MRSA), chronic myelogenous leukemia (K562), and human hepatoma (SMMC-7721) cell lines.
authors.affiliation: Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Dong
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Zeng
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000890:Anti-Infective Agents; D031621:Antiaris / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D000081223:Polycyclic Sesquiterpenes; D012639:Seeds / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C560722:7-drimen-3beta,11-diol 3-O-beta-D-glucopyranoside; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane