title: Neuro-ophthalmological features of primary diffuse leptomeningeal gliomatosis.
abstract: We performed an in-depth study of the neuro-ophthalmologic signs and symptoms of a rare but fatal disease known as primary diffuse leptomeningeal gliomatosis (PDLG). Two new cases of PDLG are described, and 22 published cases reviewed. Papilledema and sixth nerve palsy are the most common neuro-ophthalmic findings. Other abnormalities include third and fourth nerve palsies, nystagmus, and vision loss. Involvement of the visual system may be part of the initial presentation of PDLG.
authors.affiliation: Department of Ophthalmology, Hospital University La Paz, Madrid, Spain. sunoval@hotmail.com
authors.forename: Susana
authors.initials: S
authors.lastname: Noval
authors.forename: Santiago
authors.initials: S
authors.lastname: Ortiz-Pérez
authors.forename: Bernardo F
authors.initials: BF
authors.lastname: Sánchez-Dalmau
authors.forename: Gerardo
authors.initials: G
authors.lastname: Ruiz-Ares
authors.forename: Javier
authors.initials: J
authors.lastname: Arpa
authors.forename: Alfredo
authors.initials: A
authors.lastname: Adán
mesh_terms: D020434:Abducens Nerve Diseases / Q000175:diagnosis; D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use; D015170:Cerebrospinal Fluid Pressure; D016371:Cranial Irradiation; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018302:Neoplasms, Neuroepithelial / Q000175:diagnosis* / Q000188:drug therapy; D010211:Papilledema / Q000175:diagnosis; D014390:Tuberculosis, Meningeal / Q000175:diagnosis* / Q000188:drug therapy; D014786:Vision Disorders / Q000175:diagnosis; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents