title: Concise review: challenging the pluripotency of human testis-derived ESC-like cells.
abstract: Several research groups have claimed to have successfully generated pluripotent or multipotent cells from human testis. However, the pluripotent character of those cells with respect to gene expression profile and ability to generate teratomas has been called into question. Here, we critically review these reports and provide insight to guide future studies on the derivation of human pluripotent cells from testicular tissue.
authors.affiliation: Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
authors.forename: Natalia
authors.initials: N
authors.lastname: Tapia
authors.forename: Marcos J
authors.initials: MJ
authors.lastname: Araúzo-Bravo
authors.forename: Kinarm
authors.initials: K
authors.lastname: Ko
authors.forename: Hans R
authors.initials: HR
authors.lastname: Schöler
mesh_terms: D002454:Cell Differentiation; D003114:Colony-Forming Units Assay; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D039902:Multipotent Stem Cells / Q000166:cytology / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D013737:Testis / Q000166:cytology*