title: Association of PPARγ2 polymorphisms with carcass and meat quality traits in a Pietrain x Jinhua F2 population.
abstract: The PPARγ2 gene is a key regulator of both proliferation and preadipocyte differentiation in mammals. Herein its genotype and allele frequencies were analyzed using PCR-SSCP in eight pig breeds (N = 416). Two kinds of polymorphisms of the PPARγ2 gene were detected, including a previously reported shift SNP A177G (Met59Val) in exon 1 and a novel silent mutation G876A in exon 5. The results revealed that European pig breeds carry a higher allele A frequency at the A177G locus and a fixed GG genotype at the G876A locus. Allele A at the G876A locus was only found in Jinhua pigs. The association between haplotype (A177G/G876A) and carcass and meat quality traits was analyzed in a Pietrain x Jinhua F2 population (N = 248). The PPARγ2 gene was found to be significantly associated with backfat thickness at the shoulder (p < 0.05), 6-7(th) ribs (p < 0.01), last rib (p < 0.01), gluteus medius (p <0.05) and ham weight (p < 0.01). Significant effects of different haplotypes on ham weight and backfat thickness at the 6-7(th) ribs, last rib, and gluteus medius were also observed.
authors.affiliation: College of Animal Science, Zhejiang University, Zhejiang Province, P.R. China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhao
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Jiang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Guo
authors.forename: Zunzhou
authors.initials: Z
authors.lastname: Lv
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhou
authors.forename: Ningying
authors.initials: N
authors.lastname: Xu