title: Implications of obesity for drug therapy: limitations and challenges.
abstract: Obesity has become a worldwide challenge with significant health and socioeconomic implications. One of the major implications is its impact on drug therapy. In order to gain a better understanding of this impact, we surveyed the regulatory guidances, the newly approved molecular entity drug products, and drug product labels in the Physician's Desk Reference. This review summarizes the findings of the survey along with the existing knowledge on pharmacokinetic and pharmacodynamic changes associated with obesity.
authors.affiliation: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
authors.forename: R
authors.initials: R
authors.lastname: Jain
authors.forename: S M
authors.initials: SM
authors.lastname: Chung
authors.forename: L
authors.initials: L
authors.lastname: Jain
authors.forename: M
authors.initials: M
authors.lastname: Khurana
authors.forename: S W J
authors.initials: SW
authors.lastname: Lau
authors.forename: J E
authors.initials: JE
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Vaidyanathan
authors.forename: I
authors.initials: I
authors.lastname: Zadezensky
authors.forename: S
authors.initials: S
authors.lastname: Choe
authors.forename: C G
authors.initials: CG
authors.lastname: Sahajwalla
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects; D001835:Body Weight / Q000502:physiology; D003276:Contraceptives, Oral / Q000009:adverse effects; D004348:Drug Labeling; D004358:Drug Therapy; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D000890:Anti-Infective Agents; D003276:Contraceptives, Oral; D004364:Pharmaceutical Preparations