title: Do complement factor H 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome?
abstract: Typical haemolytic uraemic syndrome (HUS) is mainly caused by infections with enterohaemorrhagic Escherichia coli, whereas in atypical, nonbacteria-associated HUS, complement plays a dominant role. Recently, complement has also been shown to be involved in typical HUS. In this study, mostly weakly significant associations with homozygosities of complement allotype C7 M and inversely with factor H 402H were found, suggesting that 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome.
authors.affiliation: Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Poolpol
authors.forename: B
authors.initials: B
authors.lastname: Gadner
authors.forename: S
authors.initials: S
authors.lastname: Neururer
authors.forename: A
authors.initials: A
authors.lastname: Mellmann
authors.forename: H
authors.initials: H
authors.lastname: Karch
authors.forename: D
authors.initials: D
authors.lastname: Orth
authors.forename: R
authors.initials: R
authors.lastname: Würzner
mesh_terms: D017242:Complement Factor H / Q000235:genetics / Q000276:immunology; D003165:Complement System Proteins / Q000235:genetics; D004927:Escherichia coli Infections / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D006463:Hemolytic-Uremic Syndrome / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D009154:Mutation
chemical_list: C493495:CFH protein, human; D017242:Complement Factor H; D003165:Complement System Proteins