title: Gradient echo T2*-weighted magnetic resonance imaging revealing cerebral microbleeds in a patient with microscopic polyangiitis complicated by cerebrovascular disease.
abstract: A 67-year-old woman developed alveolar hemorrhage and was positive for the myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA). She was diagnosed as having probable microscopic polyangiitis (MPA) in accordance with the Japanese criteria. Brain computed tomographic and magnetic resonance imaging (MRI) scans revealed asymptomatic chronic cerebral hemorrhage and white matter lesions. She also later developed thalamic infarction. Gradient echo T2-weighted MRI showed cerebral microbleeds. Cerebral microbleeds in our patient represent bleeding-prone necrotizing vasculitis, which is a characteristic pathologic feature of MPA. Although cerebrovascular disease is not major complication of MPA, cerebral hemorrhage occurs more frequently than ischemic infarction, and it can be critical and fatal. Brain MRIs, including gradient echo T2-weighted imaging, should be performed on patients diagnosed as or suspected of having MPA to assess the risk of cerebral hemorrhage.
authors.affiliation: Department of Neurology, Juntendo University Shizuoka Hospital, Izunokunishi, Shizuoka, Japan. kazuo-y@juntendo.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamashiro
authors.forename: Akio
authors.initials: A
authors.lastname: Mori
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Shimada
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Furuya
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Noda
authors.forename: Takao
authors.initials: T
authors.lastname: Urabe
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Okuma
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D020520:Brain Infarction / Q000209:etiology; D002533:Cerebral Angiography / Q000379:methods; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000209:etiology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000209:etiology; D055953:Microscopic Polyangiitis / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D010291:Paresis / Q000209:etiology; D009195:Peroxidase / Q000276:immunology; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase