title: Involvement of proteoglycans in tendinopathy.
abstract: A major feature of chronic tendinopathy is a change in the nature and organisation of the extracellular matrix of tendon. Increased levels of proteoglycans have been shown in the extracellular matrix of tendinopathic tendons and these appear to influence the increased hydration and swelling of the tissue that is a feature of this condition. There is a paucity of knowledge about proteoglycans in normal and tendinopathic tendons. This review sets out to describe the nature, function and metabolism of proteoglycans present in normal tendon and in tendinopathy and outlines how changes in proteoglycan metabolism may contribute to the development and progression of this disease.
authors.affiliation: School of Human Biosciences, La Trobe University, Melbourne, Victoria 3086, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Parkinson
authors.forename: T
authors.initials: T
authors.lastname: Samiric
authors.forename: M Z
authors.initials: MZ
authors.lastname: Ilic
authors.forename: J
authors.initials: J
authors.lastname: Cook
authors.forename: C J
authors.initials: CJ
authors.lastname: Handley
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D006801:Humans; D011509:Proteoglycans / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D052256:Tendinopathy / Q000378:metabolism* / Q000503:physiopathology*; D013710:Tendons / Q000378:metabolism* / Q000503:physiopathology; D013718:Tensile Strength / Q000502:physiology
chemical_list: D011509:Proteoglycans