title: Impact of KRAS and BRAF gene mutations on targeted therapies in colorectal cancer.
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Bass
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000096:biosynthesis* / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D015398:Signal Transduction; D018631:ras Proteins / Q000096:biosynthesis* / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; C117307:KRAS protein, human; D008024:Ligands; D011518:Proto-Oncogene Proteins; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins