title: [Own and parental predictors of high level of low density lipoprotein cholesterol at children of persons with "premature" coronary heart disease].
abstract: OBJECTIVE
  To elucidate associations between high low density lipoprotein cholesterol (LDL-C) in children of persons with premature coronary heart disease (PCHD) and their own and parental characteristics.
  
  
  METHODS
  We examined members of 282 families: probands (n = 262, 70.1% men) with PCHD (onset before 55 [men] or 60 [women] years), their spouses (n = 192, 19.2% men), and children of probands (n = 372, 55.8% men) aged 5-38 years. We defined high LDL-C in children aged 5-17 years as a90 percentile (Lipid Research Clinics Program Prevalence Study), in children aged 18-38 years - > or = 3.36 mmol/l. Factors related to children's high LDL were selected by logistic regression with sex and age adjustment.
  
  
  RESULTS
  High LDL-C was found in 40/155 (25.8%) children aged 5-17 years. It was independently related to non-smoking of proband's spouse, higher own body mass index (BMI), LDL-C of proband and his spouse, lower heart rate of proband. High LDL-C was revealed in 85/217 (39.2%) children aged 18-38 years. It was independently related to metabolic syndrome of parent-nonproband, higher level of LDL-C of both parents, lower height of proband.
  
  
  CONCLUSIONS
  Most associations of high LDLAC of offsprings of patients with PCHD including negative relation to height and heart rate of proband are plausible. Association with parental nonsmoking can be result of analysis of unreliable data from small group but also reflect better economical conditions and more atherogenic nutrition of nonsmokers in Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Konnov
authors.forename: L M
authors.initials: LM
authors.lastname: Dobordzhginidze
authors.forename: A D
authors.initials: AD
authors.lastname: Deev
authors.forename: N A
authors.initials: NA
authors.lastname: Gratsianskiĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D015992:Body Mass Index; D002648:Child; D008078:Cholesterol, LDL / Q000378:metabolism*; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D008875:Middle Aged; D010290:Parents; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000378:metabolism
chemical_list: D008078:Cholesterol, LDL