title: Functional transformation of gastric parietal cells and intracellular trafficking of ion channels/transporters in the apical canalicular membrane associated with acid secretion.
abstract: The parietal cell of the gastric gland is a highly differentiated cell responsible for the gastric hydrochloric acid secretion into the lumen of the stomach. In response to stimulation of acid secretion, the parietal cells undergo well-characterized morphological transformations to recruit H⁺/K⁺-ATPase from the cytoplasmic tubulovesicles to the apical canalicular membrane. Besides H⁺ extrusion via H⁺/K⁺-ATPase, Cl⁻ efflux and K⁺ recycling across the apical canalicular membrane are necessary via chloride and potassium channels/transporters, respectively. In the last decade, a number of molecular candidates for the Cl⁻ efflux and K⁺ recycling have been identified in the apical canalicular membrane of the parietal cell. This review focuses on the functional transformation of gastric parietal cells and intracellular trafficking of ion channels/transporters expressed in the apical canalicular membrane associated with gastric acid secretion.
authors.affiliation: Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan.
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Aoyama
authors.forename: Akira
authors.initials: A
authors.lastname: Sawaguchi
mesh_terms: D000818:Animals; D021961:Cell Membrane Structures / Q000378:metabolism*; D016764:Cell Polarity; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism*; D016623:Ion Pumps / Q000235:genetics / Q000378:metabolism*; D010295:Parietal Cells, Gastric / Q000378:metabolism* / Q000648:ultrastructure; D021381:Protein Transport; D055571:Secretory Pathway
chemical_list: D007473:Ion Channels; D016623:Ion Pumps