title: Incidence of infection is inversely related to steady-state (trough) serum IgG level in studies of subcutaneous IgG in PIDD.
abstract: Results from seven studies of four subcutaneous IgG preparations in patients with primary immune deficiencies show that the incidence of infection is inversely related to the steady-state IgG level. Maintaining higher IgG levels may be beneficial, and no given level is necessarily adequate for all patients.
authors.forename: Melvin
authors.initials: M
authors.lastname: Berger
mesh_terms: D000361:Agammaglobulinemia / Q000188:drug therapy* / Q000276:immunology*; D001424:Bacterial Infections / Q000188:drug therapy*; D001987:Bronchiectasis / Q000188:drug therapy*; D017074:Common Variable Immunodeficiency / Q000188:drug therapy*; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000188:drug therapy*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000097:blood*; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology* / Q000628:therapy*; D007155:Immunologic Factors / Q000008:administration & dosage*; D008297:Male; D011014:Pneumonia / Q000188:drug therapy*
chemical_list: D007074:Immunoglobulin G; D007136:Immunoglobulins; D007155:Immunologic Factors