title: Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis.
abstract: Somitogenesis is controlled by cyclic genes such as Notch effectors and by the wave front established by morphogens such as Fgf8, but the precise mechanism of how these factors are coordinated remains to be determined. Here, we show that effectors of Notch and Fgf pathways oscillate in different dynamics and that oscillations in Notch signaling generate alternating phase shift, thereby periodically segregating a group of synchronized cells, whereas oscillations in Fgf signaling released these synchronized cells for somitogenesis at the same time. These results suggest that Notch oscillators define the prospective somite region, while Fgf oscillators regulate the pace of segmentation.
authors.affiliation: Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Niwa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Shimojo
authors.forename: Akihiro
authors.initials: A
authors.lastname: Isomura
authors.forename: Aitor
authors.initials: A
authors.lastname: González
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Miyachi
authors.forename: Ryoichiro
authors.initials: R
authors.lastname: Kageyama
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D002460:Cell Line; D004622:Embryo, Mammalian; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D010507:Periodicity; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D019170:Somites / Q000166:cytology* / Q000378:metabolism*; D019892:eIF-2 Kinase / Q000235:genetics / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D005346:Fibroblast Growth Factors; D051880:Receptors, Notch; D019892:eIF-2 Kinase; C430525:Hes7 protein, mouse; C107407:Mesp2 protein, mouse