title: [Effect of pravastatin on transportation of scutellarin in mouse liver and its mechanism].
abstract: This study is to investigate the transportation of scutellarin in cell and live models and study on mechanism of absorption and transport of scutellarin in mouse liver. The concentration of scutellarin in plasma and liver from control and pretreated groups was determined by high performance liquid chromatography. The uptake of scutellarin was examined in control hepatocytes group, induced hepatocytes group and induced hepatocytes plus pravastatin group. Pravastatin can affect the pharmacokinetics of scutellarin in mouse: CL is decreased while AUC is increased. The scutellarin absorption of hepatocyte induced group was higher than that of control group, but was decreased in the group with pravastatin added. The research showed that there was potential drug interaction between pravastatin and scutellarin. The drugs may compete for oatp2 mediated transport pathway consisted in the uptake of scutellarin in liver.
authors.affiliation: Institute of Clinical Pharmacology, Medical College, Nanchang University, Nanchang 330006, China.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Liu
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Xiong
mesh_terms: D000042:Absorption; D000818:Animals; D047310:Apigenin / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001692:Biological Transport; D002470:Cell Survival; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004347:Drug Interactions; D005965:Glucuronates / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D027701:Organic Cation Transport Proteins / Q000378:metabolism; D017035:Pravastatin / Q000378:metabolism / Q000494:pharmacology*; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology; D011897:Random Allocation
chemical_list: D005965:Glucuronates; C464433:Oatp2 protein, mouse; D027701:Organic Cation Transport Proteins; D011285:Pregnenolone Carbonitrile; C484876:scutellarin; D047310:Apigenin; D017035:Pravastatin