title: Community walking can be assessed using a 10-metre timed walk test.
abstract: BACKGROUND
  A decline in mobility is a common feature of multiple sclerosis (MS). Community walking scales are used to categorize patients in their ability to move independently. The first purpose of this study was to determine which specific gait speed corresponded with the categories of the Modified Functional Walking Categories (MFWC). The second purpose was to determine the Minimally Important Change (MIC) in absolute gait speed using the MFWC and Expanded Disability Status Scale (EDSS) as external criteria.
  
  
  METHODS
  MS patients were measured six times in 6 years. Gait velocity was measured with the 10-metre timed walk test (10-m TWT), the severity of MS was determined with the EDSS, and community walking was assessed with the MFWC. For each category of the MFWC, Receiver Operating Characteristic (ROC) curves were used to find the best possible cut-off point on the 10-m TWT. The MIC in absolute gait speed was determined using a change of one category on the MFWC or one point on the EDSS.
  
  
  RESULTS
  A strong relationship was found between gait speed and the MFWC; all areas under the ROC curves (AUCs) were between 0.74 and 0.86. The MIC in absolute gait speed could not be determined, because the AUCs were below the threshold of 0.70 and changes in gait speed were small.
  
  
  CONCLUSIONS
  Gait speed is related to community walking, but an MIC in absolute gait speed could not be determined using a minimally important change on the MFWC or the EDSS as external criteria.
authors.affiliation: Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands. j.kempen@vumc.nl
authors.forename: J C E
authors.initials: JC
authors.lastname: Kempen
authors.forename: V
authors.initials: V
authors.lastname: de Groot
authors.forename: D L
authors.initials: DL
authors.lastname: Knol
authors.forename: C H
authors.initials: CH
authors.lastname: Polman
authors.forename: G J
authors.initials: GJ
authors.lastname: Lankhorst
authors.forename: H
authors.initials: H
authors.lastname: Beckerman
mesh_terms: D004185:Disability Evaluation; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D051346:Mobility Limitation; D009103:Multiple Sclerosis / Q000150:complications*; D012372:ROC Curve; D016138:Walking