title: Use of in-cycle antimüllerian hormone levels to predict cycle outcome.
abstract: OBJECTIVE
  The goal of this work is to expand the usefulness of antimüllerian hormone (AMH) in predicting in vitro fertilization cycle outcome by demonstrating that AMH concentration obtained in an ongoing treatment cycle predicts both oocyte number and pregnancy.
  
  
  METHODS
  Serum samples were obtained from 190 in vitro fertilization patients at onset of follicle-stimulating hormone stimulation. These were analyzed retrospectively during a single cycle in which clinicians were blinded to the results. Our major outcome measures were the number of oocytes obtained and ongoing pregnancy.
  
  
  RESULTS
  Patients with an initial AMH concentration of >3 ng/mL were found to produce a mean of 19.8 oocytes and had an ongoing pregnancy rate of 60.3%. In contrast, those with AMH values of ≤1 ng/mL yielded a mean of 6.2 oocytes and had an ongoing pregnancy rate of 23.4% (P < .0001 for both).
  
  
  CONCLUSIONS
  Greater AMH serum concentration strongly predicts an increased number of oocytes and ongoing pregnancy (P ≤ .0001).
authors.affiliation: Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Providence, RI, USA. ablazar@wihri.org
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Blazar
authors.forename: Geralyn
authors.initials: G
authors.lastname: Lambert-Messerlian
authors.forename: Richard
authors.initials: R
authors.lastname: Hackett
authors.forename: Stephan
authors.initials: S
authors.lastname: Krotz
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Carson
authors.forename: Jared C
authors.initials: JC
authors.lastname: Robins
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D009865:Oocytes / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D054304:Anti-Mullerian Hormone