title: Killing of tumor cells: a drama in two acts.
abstract: Cancer still represents a major health problem worldwide, which urges the development of more effective strategies. Resistance to chemotherapy, a major obstacle for cancer eradication, is mainly related to an intrinsic failure to activate the apoptotic pathways. However, a protective effect of autophagy toward cancer cells has been recently observed, thus adding further complexity to the development of an effective approach counteracting cancer cell growth and improving the response to therapy.
authors.affiliation: Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Giansanti
authors.forename: Micol
authors.initials: M
authors.lastname: Tillhon
authors.forename: Giuliano
authors.initials: G
authors.lastname: Mazzini
authors.forename: Ennio
authors.initials: E
authors.lastname: Prosperi
authors.forename: Paolo
authors.initials: P
authors.lastname: Lombardi
authors.forename: A Ivana
authors.initials: AI
authors.lastname: Scovassi
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001343:Autophagy / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents