title: Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma.
abstract: COX-2 and 5-LOX are up-regulated in ESCC. This study aims to determine the efficacy of COX-2 inhibitor, 5-LOX inhibitor and their combination on ESCC. Nimesulide can suppress cell growth and promote apoptosis, accompanied with a decrease of PGE(2) production. AA861 has the similar effect with a down-regulation of LTB(4). In animal experiment, the tumor volumes in drug-treated groups were significantly smaller with the lowest rates of Ki-67 positive cells. In conclusion, either COX-2 inhibitor or 5-LOX inhibitor can suppress ESCC. Dual inhibition of COX-2 and 5-LOX pathway may present a superior anticancer efficacy to either inhibition of COX-2 or 5-LOX alone.
authors.affiliation: Department of Gastroenterology, Beijing Digestive Disease Center, Beijing Friendship Hospital affiliated to Capital Medical University, Yong'an Road 95, Beijing, China.
authors.forename: Hai-yun
authors.initials: HY
authors.lastname: Shi
authors.forename: Fu-jing
authors.initials: FJ
authors.lastname: Lv
authors.forename: Sheng-tao
authors.initials: ST
authors.lastname: Zhu
authors.forename: Qing-gang
authors.initials: QG
authors.lastname: Wang
authors.forename: Shu-tian
authors.initials: ST
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D004357:Drug Synergism; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016859:Lipoxygenase Inhibitors; D001094:Arachidonate 5-Lipoxygenase; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human