title: [A case of autoimmune hepatitis following acute hepatitis A].
abstract: The pathogenesis of autoimmune hepatitis (AIH) is unclear, but viral infections have been proposed as a potential trigger in patients with genetic predisposition. We report a case of AIH following acute hepatitis A (AHA). A 57-year-old woman presented with fatigue and pitting edema for last 3 months. She had been diagnosed as an AHA 15 months ago based on clinical features, biochemical tests and positive HAV IgM antibody at a local clinic. Her biochemical tests was normalized one month after AHA diagnosis, but the serum levels of aminotransferase started to rise four months after AHA diagnosis. Antinuclear antibody was positive at a titer of 1:40, and anti-smooth muscle antibody was also positive. Hypergammaglobulinemia and liver pathology were typical for AIH. The patients had a score of 17 according to the International Autoimmune Hepatitis Group's system. She was given prednisolone and azathioprine and showed complete response to immunosuppressive therapy. The present case is the first report on AIH triggered by AHA in Korea.
authors.affiliation: Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
authors.forename: Young Doo
authors.initials: YD
authors.lastname: Kim
authors.forename: Kyung Ah
authors.initials: KA
authors.lastname: Kim
authors.forename: Woo Sun
authors.initials: WS
authors.lastname: Rou
authors.forename: June Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Tae June
authors.initials: TJ
authors.lastname: Song
authors.forename: Won Ki
authors.initials: WK
authors.lastname: Bae
authors.forename: Nam Hoon
authors.initials: NH
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D000974:Antibodies, Antinuclear / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000097:blood; D001323:Autoantibodies / Q000032:analysis; D001379:Azathioprine / Q000627:therapeutic use; D005260:Female; D006506:Hepatitis A / Q000150:complications / Q000188:drug therapy*; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000175:diagnosis; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007166:Immunosuppressive Agents; C051931:myasthenia gravis anti-skeletal muscle antibody; D011239:Prednisolone; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001379:Azathioprine