title: Pathogenesis of acne vulgaris: what's new, what's interesting and what may be clinically relevant.
abstract: Acne vulgaris is the most common skin disorder seen in dermatology and primary care offices today with significant associated morbidity. The pathogenesis of acne is complex and multifactorial, and there continues to be an influx of new information to increase our understanding of this chronic disease. Recent advances in acne pathogenesis will be discussed, including theories regarding the sequence of events in acne formation, the functions of P. acnes, TLR involvement and role of the sebaceous gland and factors influencing sebum production.
authors.affiliation: Valley Hospital Medical Center, 620 Shadow Lane, Las Vegas, NV 89106, USA.
authors.forename: Susun
authors.initials: S
authors.lastname: Bellew
authors.forename: Diane
authors.initials: D
authors.lastname: Thiboutot
authors.forename: James Q
authors.initials: JQ
authors.lastname: Del Rosso
mesh_terms: D000152:Acne Vulgaris / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D011425:Propionibacterium acnes / Q000302:isolation & purification*; D012627:Sebaceous Glands / Q000378:metabolism; D012629:Sebum / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism*
chemical_list: D051193:Toll-Like Receptors