title: Prevention of lyme disease: promising research or sisyphean task?
abstract: Borrelia burgdorferi sensu lato (Spirochaetes) is a group of at least 12 closely related species, some of which are responsible for chronic zoonotic infection that may cause Lyme disease. The only experimentally confirmed vector transmitting Borrelia to mammals is the Ixodes ticks. Borrelia is a highly adapted pathogen that can survive in the host organism in spite of the intense immune responses. Some patients have chronic long-lasting complications despite antibiotic therapy, probably due to adverse effects of the immune responses. A preventive vaccine against this bacterium has not been available due to the relatively broad spectrum and antigenic variability of Borrelia-surface lipoproteins and the different epitope recognition by experimental animals and humans. Although a human vaccine was marketed in the USA, it has been already pulled off the market. In addition, this vaccine was effective only in the USA, where the only pathogenic species is B. burgdorferi sensu stricto. Recent data indicate that a broadly effective vaccine will to be composed of a mixture of several antigens or multiple epitopes.
authors.affiliation: Department of Immunology, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Krupka
authors.forename: Katerina
authors.initials: K
authors.lastname: Zachova
authors.forename: Evzen
authors.initials: E
authors.lastname: Weigl
authors.forename: Milan
authors.initials: M
authors.lastname: Raska
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000940:Antigenic Variation; D000942:Antigens, Bacterial / Q000276:immunology* / Q000378:metabolism; D000954:Antigens, Surface / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology* / Q000378:metabolism; D001428:Bacterial Vaccines / Q000276:immunology*; D025065:Borrelia burgdorferi / Q000276:immunology / Q000378:metabolism; D006801:Humans; D018884:Ixodes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D008074:Lipoproteins / Q000276:immunology* / Q000378:metabolism; D008193:Lyme Disease / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D051379:Mice; D008969:Molecular Sequence Data; D014481:United States; D014611:Vaccination / Q000009:adverse effects
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D008074:Lipoproteins; C072045:OspA protein; C105546:VlsE protein, Borrelia burgdorferi; C077030:OspB protein, Borrelia burgdorferi