title: The effect of pharmacological treatment on ADMA in patients with heart failure.
abstract: Asymmetric dimethylarginine (ADMA) plays a crucial role in the arginine-nitric oxide (NO) pathway. NO plays an important role in controlling vascular tone and regulates the contractile properties of cardiac myocytes. The purpose of this study was to investigate the effect of pharmacological treatment on asymmetrical dimethylarginine (ADMA) plasma levels in patients with acute congestive heart failure (HF). Patients with symptomatic acute congestive HF (NYHA Class III-IV) and impaired left ventricular (LV) function (ejection fraction less than 40 percent) were included in the study. ADMA and SDMA concentrations were assessed before and after pharmacological treatment in 18 critically ill patients on the intensive care unit by high performance liquid chromatography. All patients received a complete pharmacological treatment (diuretics, digoxin, ACE-inhibitors or angiotensin receptor blockers, and nitroglicerin) for the treatment of acute congestive HF. ADMA plasma levels of critically ill patients were significantly higher after pharmacological treatment respect baseline values (pre-treatment). In critically ill patients with acute congestive HF acute renal impairment function and the modulation of NOS determine plasma ADMA/SDMA levels after therapy.
authors.affiliation: Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy. griccioni@hotmail.com
authors.forename: Graziano
authors.initials: G
authors.lastname: Riccioni
authors.forename: Lorenza
authors.initials: L
authors.lastname: Speranza
authors.forename: Luca
authors.initials: L
authors.lastname: Scotti
authors.forename: Valentina
authors.initials: V
authors.lastname: Bucciarelli
authors.forename: Emanuela
authors.initials: E
authors.lastname: Di Ilio
authors.forename: Nicolantonio
authors.initials: N
authors.lastname: D'Orazio
authors.forename: Mirko
authors.initials: M
authors.lastname: Pesce
authors.forename: Antonio
authors.initials: A
authors.lastname: Aceto
authors.forename: Valeria
authors.initials: V
authors.lastname: Sorrenti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Frigiola
authors.forename: Tonino
authors.initials: T
authors.lastname: Bucciarelli
mesh_terms: D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine