title: Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders.
abstract: BACKGROUND
  Accumulating evidence suggests that dysregulation of the immune system is involved in the pathophysiology of autism spectrum disorders (ASD). The aim of the study was to explore immunological markers in peripheral plasma samples from non-medicated subjects with high-functioning ASD.
  
  
  RESULTS
  A multiplex assay for cytokines and chemokines was applied to plasma samples from male subjects with high-functioning ASD (n = 28) and matched controls (n = 28). Among a total of 48 analytes examined, the plasma concentrations of IL-1β, IL-1RA, IL-5, IL-8, IL-12(p70), IL-13, IL-17 and GRO-α were significantly higher in subjects with ASD compared with the corresponding values of matched controls after correction for multiple comparisons.
  
  
  CONCLUSIONS
  The results suggest that abnormal immune responses as assessed by multiplex analysis of cytokines may serve as one of the biological trait markers for ASD.
authors.affiliation: Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan. k-suzuki@hama-med.ac.jp
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Iwata
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kameno
authors.forename: Chie
authors.initials: C
authors.lastname: Shimmura
authors.forename: Satomi
authors.initials: S
authors.lastname: Kawai
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Yoshihara
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Wakuda
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Takebayashi
authors.forename: Shu
authors.initials: S
authors.lastname: Takagai
authors.forename: Kaori
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Kenji J
authors.initials: KJ
authors.lastname: Tsuchiya
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Iwata
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Tsujii
authors.forename: Toshirou
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Norio
authors.initials: N
authors.lastname: Mori
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood / Q000276:immunology; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D006801:Humans; D008297:Male
chemical_list: D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines