title: Dynamics of insulin secretion and the clinical implications for obesity and diabetes.
abstract: Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism. Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and discusses their clinical relevance.
authors.affiliation: Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. seino@med.kobe-u.ac.jp
authors.forename: Susumu
authors.initials: S
authors.lastname: Seino
authors.forename: Tadao
authors.initials: T
authors.lastname: Shibasaki
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Minami
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D003594:Cytoplasmic Granules / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000503:physiopathology*; D004435:Eating / Q000502:physiology; D044882:Glucose Metabolism Disorders / Q000503:physiopathology; D020662:Guanine Nucleotide Exchange Factors / Q000819:agonists / Q000502:physiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D054795:Incretins / Q000502:physiology; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008954:Models, Biological; D009765:Obesity / Q000188:drug therapy / Q000503:physiopathology*; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology; D012636:Secretory Rate; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D020662:Guanine Nucleotide Exchange Factors; D007004:Hypoglycemic Agents; D054795:Incretins; D007328:Insulin; D015221:Potassium Channels; C442864:RAPGEF4 protein, human; D000242:Cyclic AMP