title: 18F-FDG uptake in primary lung cancer as a predictor of intratumoral vessel invasion.
abstract: OBJECTIVE
  This study investigated how fluorodeoxyglucose (FDG) uptake on PET in the primary tumor may predict intratumoral vessel invasion (IVI) in it.
  
  
  METHODS
  A total of 512 patients with lung neoplasms determined by a surgical procedure and histopathological diagnosis had undergone FDG-PET scanning.
  
  
  RESULTS
  Among the 440 cases confirmed to be malignant, the maximum standardized uptake value (SUV(max)) was significantly lower in IVI-negative cases than IVI-positive cases (P < 0.001). In the substudy on adenocarcinoma (AC), SUV(max) was significantly lower in IVI-negative cases too (P < 0.001), but SUV(max) in squamous cell carcinoma was without significant difference. In addition, IVI was associated with a significantly higher probability of lymph node metastasis (P < 0.001).
  
  
  CONCLUSIONS
  This study indicates that a malignant lung tumor with higher SUV(max) has a significantly higher probability of IVI and lymph node metastasis, particularly if the malignancy is an AC.
authors.affiliation: Department of Radiology, Sapporo Minamisanjo Hospital, 4-2 Minami3 Nishi6, Sapporo, Hokkaido, 060-0063, Japan. pkanzug@me.com
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Mitsuhito
authors.initials: M
authors.lastname: Kaji
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kato
authors.forename: Keidai
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kadoya
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D001706:Biopsy; D018287:Carcinoma, Large Cell / Q000175:diagnosis / Q000000981:diagnostic imaging; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000000981:diagnostic imaging; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000000981:diagnostic imaging; D003952:Diagnostic Imaging / Q000379:methods; D019788:Fluorodeoxyglucose F18 / Q000494:pharmacology*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D011877:Radionuclide Imaging; D012189:Retrospective Studies
chemical_list: D019788:Fluorodeoxyglucose F18