title: Antitumor potential induction and free radicals production in melanoma cells by Boron Neutron Capture Therapy.
abstract: Antiproliferative and oxidative damage effects occurring in Boron Neutron Capture Therapy (BNCT) in normal fibroblasts and melanoma cell lines were analyzed. Melanoma cells and normal fibroblasts were treated with different concentrations of Boronophenylalanine and irradiated with thermal neutron flux. The cellular viability and the oxidative stress were determined. BNCT induced free radicals production and proliferative potential inhibition in melanoma cells. Therefore, this therapeutic technique could be considered efficient to inhibit growth of melanoma with minimal effects on normal tissues.
authors.affiliation: Biochemical and Biophysical Laboratory, Butantan Institute, São Paulo, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Faião-Flores
authors.forename: P R P
authors.initials: PR
authors.lastname: Coelho
authors.forename: R O R
authors.initials: RO
authors.lastname: Muniz
authors.forename: G S
authors.initials: GS
authors.lastname: Souza
authors.forename: J
authors.initials: J
authors.lastname: Arruda-Neto
authors.forename: Durvanei A
authors.initials: DA
authors.lastname: Maria
mesh_terms: D000818:Animals; D016754:Boron Neutron Capture Therapy; D002460:Cell Line; D045744:Cell Line, Tumor; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D008546:Melanoma, Experimental / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice
chemical_list: D005609:Free Radicals