title: The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population.
abstract: The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified.
authors.affiliation: Department of Human Genetics and Molecular Diagnosis, Institute of Genetics, University of Bucharest, Bucharest Romania.
authors.forename: Danut
authors.initials: D
authors.lastname: Cimponeriu
authors.forename: Pompilia
authors.initials: P
authors.lastname: Apostol
authors.forename: Irina
authors.initials: I
authors.lastname: Radu
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Craciun
authors.forename: Cristian
authors.initials: C
authors.lastname: Serafinceanu
authors.forename: Mihai
authors.initials: M
authors.lastname: Toma
authors.forename: Cristian
authors.initials: C
authors.lastname: Panaite
authors.forename: Dan
authors.initials: D
authors.lastname: Cheta