title: Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di(indolyl)indolin-2-ones.
abstract: An operation friendly protocol for the synthesis of novel di(indolyl)indolin-2-ones via Cu(OTf)(2) catalyzed bis-addition of N-allyl and N-propargyl indole with isatin was developed. This methodology allowed us to achieve the products in excellent yields without requiring purification technique like column chromatography. All the synthesized compounds were evaluated for their in vivo anticonvulsant activity against maximal electroshock test. Six compounds showed maximum activity compared to the standard drug phenytoin. The scope of the new molecules as antimicrobial agents were tested against two bacterial strains (Staphylococcus aureus and Escherichia coli) and one fungal strain (Candida albicans).
authors.affiliation: Organic Chemistry Division, Central Leather Research Institute, Adyar, Chennai 600 020, Tamil Nadu, India.
authors.forename: Chandrasekaran
authors.initials: C
authors.lastname: Praveen
authors.forename: Asairajan
authors.initials: A
authors.lastname: Ayyanar
authors.forename: Paramasivan Thirumalai
authors.initials: PT
authors.lastname: Perumal
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002384:Catalysis; D002478:Cells, Cultured; D003300:Copper / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007510:Isatin / Q000737:chemistry; D051379:Mice; D015394:Molecular Structure; D010672:Phenytoin / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000927:Anticonvulsants; D007211:Indoles; C456900:indolin-2-one; D010672:Phenytoin; D003300:Copper; D007510:Isatin