title: The first Australian experience of heterotopic grafting of cryopreserved ovarian tissue: evidence of establishment of normal ovarian function.
abstract: Cryostorage of reproductive potential, in the form of ovarian cortex, for young women about to undergo cytotoxic therapies has been offered clinically for some time. However, the prospects of re-establishing reproductive function using this tissue remain unclear. We now report reproducible follicular development, oocyte retrieval and embryo development following heterotopic grafting of cryopreserved ovarian cortex which had been stored for over 10 years.
authors.affiliation: Melbourne IVF, East Melbourne, Victoria 3002, Australia. kate.stern@mivf.com.au
authors.forename: Catharyn J
authors.initials: CJ
authors.lastname: Stern
authors.forename: Manuela G
authors.initials: MG
authors.lastname: Toledo
authors.forename: Lyndon G
authors.initials: LG
authors.lastname: Hale
authors.forename: Debra A
authors.initials: DA
authors.lastname: Gook
authors.forename: David H
authors.initials: DH
authors.lastname: Edgar
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001315:Australia; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D015925:Cryopreservation; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004958:Estradiol / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy; D010053:Ovary / Q000502:physiology* / Q000637:transplantation*; D011241:Prednisone / Q000627:therapeutic use; D011374:Progesterone / Q000097:blood; D020554:Sperm Injections, Intracytoplasmic; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011374:Progesterone; D004958:Estradiol; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011241:Prednisone