title: Analysis of co-spray-dried meloxicam-mannitol systems containing crystalline microcomposites.
abstract: The crystal size, form, wettability and rate of dissolution of a drug are factors limiting its nasal or pulmonary administration. The aim of this work was to achieve an ideal crystal habit, good wettability and the rapid release of meloxicam (MEL), a poorly water-soluble non-steroidal anti-inflammatory drug. The structures of MEL and the carrier-based systems were analysed by differential scanning calorimetry, X-ray diffractometry and Fourier transform infrared spectroscopy. The particle size and morphology were investigated by laser diffraction and SEM analyses. The novelty of this work was the use of a co-spray-drying technique, which resulted in mannitol-based crystalline microcomposites (1-6 μm) containing MEL microcrystals (1-5 μm). The particle size and form of the MEL microcrystals were adjusted by a top-down method. The presence of mannitol (with a MEL:mannitol mass ratio of 1:1) with additives ensured the homogeneous distribution of MEL in the microcomposites with good wettability and rapid release (100% MEL within 5 min).
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Eötvös 6, H-6720 Szeged, Hungary.
authors.forename: Anita
authors.initials: A
authors.lastname: Pomázi
authors.forename: Rita
authors.initials: R
authors.lastname: Ambrus
authors.forename: Péter
authors.initials: P
authors.lastname: Sipos
authors.forename: Piroska
authors.initials: P
authors.lastname: Szabó-Révész
mesh_terms: D000336:Aerosols; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D018360:Crystallography, X-Ray; D003890:Desiccation; D004337:Drug Carriers; D004339:Drug Compounding; D007700:Kinetics; D008353:Mannitol / Q000737:chemistry*; D000077239:Meloxicam; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010316:Particle Size; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D013843:Thiazines / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*; D017155:Wettability
chemical_list: D000336:Aerosols; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D013843:Thiazines; D013844:Thiazoles; D008353:Mannitol; D000077239:Meloxicam