title: Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury.
abstract: To elucidate the molecular mechanism involved in methylmercury-induced cerebellar disorder, we performed DNA microarray analysis of the cerebellum of methylmercury-treated mice. The expression levels of 21 genes were elevated 2-fold or higher in response to methylmercury, including many genes encoding proteins involved in inflammatory reactions associated with chemokines. The expression levels of 11 genes were reduced by half or more in response to methylmercury.
authors.affiliation: Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences,Tohoku University, Sendai, Miyagi 980-8578, Japan.
authors.forename: Gi-Wook
authors.initials: GW
authors.lastname: Hwang
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Lee
authors.forename: Katsunori
authors.initials: K
authors.lastname: Ryoke
authors.forename: Fujio
authors.initials: F
authors.lastname: Matsuyama
authors.forename: Jong-Mu
authors.initials: JM
authors.lastname: Kim
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Akira
authors.initials: A
authors.lastname: Naganuma
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000473:pathology; D004785:Environmental Pollutants / Q000633:toxicity*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D008297:Male; D008767:Methylmercury Compounds / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D004785:Environmental Pollutants; D008767:Methylmercury Compounds; C004925:methylmercuric chloride