title: Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of APOA5-1131T>C and APOC3-482C>T in Chinese healthy young adults.
abstract: OBJECTIVE
  Changes in lipid profiles have been shown to be associated with diet and apolipoprotein (APO) polymorphisms. Therefore, 2 polymorphisms, i.e. APOA5-1131T>C and APOC3-482C>T, and serum lipids were examined in a Chinese healthy young population with high-carbohydrate/low-fat (HC/LF) diet intervention.
  
  
  METHODS
  After a wash-out diet for 7 days, 56 young adults (22.89 ± 1.80 years) received the HC/LF diet for 6 days. Body mass index (BMI) and fasting serum lipid profiles at baseline, after the wash-out diet, and after the HC/LF diet were measured.
  
  
  RESULTS
  APOA5-1131C carriers had higher triglyceride (TG) and TG-rich lipoprotein TG (TRL-TG) levels at baseline and after the HC/LF diet, though this mainly corresponded to the female cohort. APOC3-482T carriers had higher TRL-TG levels following the wash-out and HC/LF diets, but these were not directly attributable to a single gender.
  
  
  CONCLUSIONS
  Both polymorphisms may play an important role in the elevated TG and TRL-TG levels induced by the HC/LF diet, especially in females, thus indicating a potential dietary prevention of coronary heart disease in this Chinese cohort.
authors.affiliation: Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Lin
authors.forename: Ding Zhi
authors.initials: DZ
authors.lastname: Fang
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Sarah
authors.initials: S
authors.lastname: Shigdar
authors.forename: Li Ying
authors.initials: LY
authors.lastname: Xiao
authors.forename: Xue Dong
authors.initials: XD
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Duan
mesh_terms: D000328:Adult; D000072040:Apolipoprotein A-V; D053305:Apolipoprotein C-III / Q000235:genetics*; D001054:Apolipoproteins A / Q000235:genetics*; D015992:Body Mass Index; D002681:China; D015331:Cohort Studies; D018752:Diet, Fat-Restricted; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced / Q000235:genetics*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D053305:Apolipoprotein C-III; D001054:Apolipoproteins A; D004040:Dietary Carbohydrates; D008074:Lipoproteins; D014280:Triglycerides; C030087:lipoprotein triglyceride