title: Synthesis, characterization and biological evaluation of some 16β-azolyl-3β-amino-5α-androstane derivatives as potential anticancer agents.
abstract: A series of new 16β-azolyl-3β-amino-5α-androstane derivatives were synthesized and characterized. The new compounds were screened for their anticancer activity against the human cancer cell lines SW480, A549, HepG2, HeLa and SiHa in vitro using the MTT assay. The results of the in vitro study showed that a number of compounds have shown IC(50) values lower than 20 μM against the five cancer cell lines.
authors.affiliation: State Key Laboratory of Virology, Ministry of Education Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University School of Pharmaceutical Science, Wuhan 430071, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Guo
authors.forename: Guolan
authors.initials: G
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Xianran
authors.initials: X
authors.lastname: He
authors.forename: Zhongyuan
authors.initials: Z
authors.lastname: Wu
authors.forename: Yuling
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yuanhu
authors.initials: Y
authors.lastname: Pan
authors.forename: Guofu
authors.initials: G
authors.lastname: Qiu
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Xianming
authors.initials: X
authors.lastname: Hu
mesh_terms: D000731:Androstanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000731:Androstanes; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D014230:Triazoles