title: Metabolic engineering of microbial pathways for advanced biofuels production.
abstract: Production of biofuels from renewable resources such as cellulosic biomass provides a source of liquid transportation fuel to replace petroleum-based fuels. This endeavor requires the conversion of cellulosic biomass into simple sugars, and the conversion of simple sugars into biofuels. Recently, microorganisms have been engineered to convert simple sugars into several types of biofuels, such as alcohols, fatty acid alkyl esters, alkanes, and terpenes, with high titers and yields. Here, we review recently engineered biosynthetic pathways from the well-characterized microorganisms Escherichia coli and Saccharomyces cerevisiae for the production of several advanced biofuels.
authors.affiliation: Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA.
authors.forename: Fuzhong
authors.initials: F
authors.lastname: Zhang
authors.forename: Sarah
authors.initials: S
authors.lastname: Rodriguez
authors.forename: Jay D
authors.initials: JD
authors.lastname: Keasling
mesh_terms: D000438:Alcohols / Q000378:metabolism; D056804:Biofuels; D053898:Biosynthetic Pathways / Q000235:genetics / Q000502:physiology*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D007218:Industrial Microbiology / Q000639:trends; D060847:Metabolic Engineering; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D013729:Terpenes / Q000378:metabolism
chemical_list: D000438:Alcohols; D056804:Biofuels; D005227:Fatty Acids; D013729:Terpenes