title: Serum adipokine profiles in Kawasaki disease.
abstract: Adipokines are cytokines derived from adipose tissue. Recently it has been established that adipokines are closely linked to the pathophysiology of not only metabolic diseases, such as diabetes mellitus, obesity, and atherosclerosis, but also to inflammation and immune diseases. In this study we measured serum levels of adipokines in patients with acute Kawasaki disease to investigate the role of adipokines in the pathophysiology of Kawasaki disease. Serum resistin, high-molecular-weight (HMW) adiponectin, leptin, and visfatin levels were measured by enzyme-linked immunosorbent assay in a total of 117 subjects: 56 patients with acute Kawasaki disease, 30 healthy children, and 31 patients with acute infectious diseases. Serum resistin levels in patients with Kawasaki disease were significantly higher than those of healthy children and patients with acute infectious diseases. In contrast, mean serum HMW adiponectin, leptin, and visfatin levels in patients with Kawasaki disease exhibited no statistically significant differences compared with those in healthy children and patients with infectious diseases. Serum resistin levels decreased significantly after administration of intravenous immune globulin. Serum resistin levels on admission were significantly higher in nonresponders compared with responders to intravenous immune globulin therapy. A multivariate model revealed that C-reactive protein was a factor that was significantly related to elevated serum resistin level in patients with Kawasaki disease. In patients with Kawasaki disease, serum resistin levels were elevated, but decreased to nearly normal after intravenous administration of immune globulin. In contrast, serum HMW adiponectin, leptin, and visfatin levels showed no statistically significant changes. These findings suggest that resistin plays an important role, while other adipokines do not play a major role, in the pathogenesis of Kawasaki disease.
authors.affiliation: Department of Pediatrics, School of Medicine, Faculty of Medicine, Toho University, Tokyo 143-8541, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kemmotsu
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Saji
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kusunoki
authors.forename: Nahoko
authors.initials: N
authors.lastname: Tanaka
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nishimura
authors.forename: Akira
authors.initials: A
authors.lastname: Ishiguro
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kawai
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D002675:Child, Preschool; D003141:Communicable Diseases / Q000097:blood; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D020738:Leptin / Q000097:blood; D008297:Male; D008970:Molecular Weight; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D052243:Resistin / Q000097:blood
chemical_list: D054392:Adipokines; D052242:Adiponectin; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D020738:Leptin; D052243:Resistin; D002097:C-Reactive Protein; D054409:Nicotinamide Phosphoribosyltransferase