title: PUCA pump and IABP comparison: analysis of hemodynamic and energetic effects using a digital computer model of the circulation.
abstract: The pulsatile catheter pump (PUCA pump) is a left ventricular assist device that provides additional flow to the left ventricle. It is usually run in order to ensure a counterpulsation effect, as in the case of the intra-aortic balloon pump (IABP). Because of this similarity, a comparison between the PUCA pump and the IABP was conducted from both the hemodynamic and energetic points of view. Numerical models of the two devices were created and connected to the CARDIOSIM cardiovascular simulator. The PUCA and IABP models were then verified using in vivo experimental data and literature data, respectively. Numerical experiments were conducted for different values of left ventricular end systolic elastance (Els) and systemic arterial compliance (Csa). The energetic comparison was conducted taking into account the diastolic pressure time index and the endocardial viability ratio. Hemodynamic results expressed as cardiac output (CO) and mean coronary blood flow (CBF) show that both the IABP and the PUCA pump efficacy decrease with higher values of Els and Csa. The IABP especially shows higher sensitivity to these parameters, to the extent that in some cases CO actually drops and CBF does not increase. On the other hand, for lower values of Csa, IABP performance improves so much that the PUCA pump flow needs to be increased in order to ensure a hemodynamic effect comparable to that of the IABP. Energetic results show a trend similar to the hemodynamic ones. The study will be continued by investigating other energetic variables and the autonomic response of the cardiovascular system.
authors.affiliation: Institute of Clinical Physiology, CNR, Rome-Italy. libera.fresiello@gmail.com
authors.forename: Libera
authors.initials: L
authors.lastname: Fresiello
authors.forename: Y John
authors.initials: YJ
authors.lastname: Gu
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Ferrari
authors.forename: Arianna
authors.initials: A
authors.lastname: Di Molfetta
authors.forename: Gerhard
authors.initials: G
authors.lastname: Rakhorst
mesh_terms: D002302:Cardiac Output; D057785:Catheters; D003187:Compliance; D003198:Computer Simulation; D003326:Coronary Circulation; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D007423:Intra-Aortic Balloon Pumping / Q000295:instrumentation*; D008955:Models, Cardiovascular; D009716:Numerical Analysis, Computer-Assisted; D011474:Prosthesis Design; D011673:Pulsatile Flow; D016277:Ventricular Function, Left; D017725:Ventricular Pressure