title: Efficacy of a mycotoxin binder against dietary fumonisin, deoxynivalenol, and zearalenone in rats.
abstract: It was hypothesized that a mycotoxin binder, Grainsure E, would inhibit adverse effects of a mixture of fumonisin B1, deoxynivalenol, and zearalenone in rats. For 14 and 28 days, 8-10 Sprague-Dawley rats were fed control diet, Grainsure E (0.5%), toxins (7 μg fumonisin B1/g, 8 μg of deoxynivalenol/g and 0.2 μg of zearalenone/g), toxins (12 μg of fumonisin B1/g, 9 μg of deoxynivalenol/g, and 0.2 μg of zearalenone/g + Grainsure E), or pair-fed to control for food intake of toxin-fed rats. After 28 days, decreased body weight gain was prevented by Grainsure E in toxin-fed female rats, indicating partial protection against deoxynivalenol and fumonisin B1. Two effects of fumonisin B1 were partly prevented by Grainsure E in toxin-fed rats, increased plasma alanine transaminase (ALT) and urinary sphinganine/sphingosine, but sphinganine/sphingosine increase was not prevented in females at the latter time point. Grainsure E prevented some effects of fumonisin B1 and deoxynivalenol in rats.
authors.affiliation: Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA.
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Qiang
authors.forename: My
authors.initials: M
authors.lastname: Truong
authors.forename: Koen
authors.initials: K
authors.lastname: Meynen
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Murphy
authors.forename: Suzanne
authors.initials: S
authors.lastname: Hendrich
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control; D004032:Diet; D005260:Female; D037341:Fumonisins / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control; D008107:Liver Diseases; D008297:Male; D009183:Mycotoxins; D051381:Rats; D017207:Rats, Sprague-Dawley; D014255:Trichothecenes / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity; D015025:Zearalenone / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity
chemical_list: D037341:Fumonisins; D009183:Mycotoxins; D014255:Trichothecenes; C056933:fumonisin B1; D015025:Zearalenone; C007262:deoxynivalenol