title: Myth: tocolysis for prevention of preterm birth has a major role in modern obstetrics.
abstract: Tocolytics are widely used to reduce uterine activity in the context of preterm labour. Growing evidence that bacterial colonization of fetal membranes and amniotic fluid triggers an inflammatory response in mother and fetus and leads to preterm labour and long term neurological and respiratory complications in the neonate also raises questions about the desirability of prolonging pregnancy in this context. Combined with recent meta-analyses that fail to demonstrate improvements in neonatal outcome with tocolytic use, and a poor maternal/fetal side-effect profile, the case for continued use of these drugs needs to be questioned.
authors.affiliation: Institute for Women's Health, University College London, UK.
authors.forename: A P
authors.initials: AP
authors.lastname: Kenyon
authors.forename: D
authors.initials: D
authors.lastname: Peebles
mesh_terms: D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000188:drug therapy / Q000517:prevention & control*; D009774:Obstetrics; D011247:Pregnancy; D047928:Premature Birth / Q000188:drug therapy / Q000517:prevention & control*; D015145:Tocolysis / Q000379:methods*; D015149:Tocolytic Agents / Q000627:therapeutic use*
chemical_list: D015149:Tocolytic Agents