title: Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-D-xylofuranose.
abstract: A simple and efficient synthetic approach toward a series of chiral aryl boronate esters, starting from D-xylose, as anti-microbial agents, is described herein. Minimum inhibitory concentration and zone of inhibition revealed that these derivatives exhibit potent anti-bacterial and anti-fungal properties. Herein, we report the first anti-microbial activity of this class of compounds. All products have been characterized by NMR ((1)H, (13)C and (11)B), IR, elemental and mass spectral study.
authors.affiliation: Organometallic Group, I & P C Division, Discovery Lab D-214, Indian Institute of Chemical Technology, Hyderabad, Uppal Road, Tarnaka, Hyderabad 500007, India. trivedi@iict.res.in
authors.forename: Rajiv
authors.initials: R
authors.lastname: Trivedi
authors.forename: E
authors.initials: E
authors.lastname: Rami Reddy
authors.forename: Ch
authors.initials: Ch
authors.lastname: Kiran Kumar
authors.forename: B
authors.initials: B
authors.lastname: Sridhar
authors.forename: K
authors.initials: K
authors.lastname: Pranay Kumar
authors.forename: M
authors.initials: M
authors.lastname: Srinivasa Rao
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001881:Borates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014994:Xylose / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001881:Borates; D004952:Esters; D014994:Xylose