title: Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase.
abstract: Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer's disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.72 μmol/L.
authors.affiliation: School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
authors.forename: Raju
authors.initials: R
authors.lastname: Suresh Kumar
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ashraf Ali
authors.forename: Hasnah
authors.initials: H
authors.lastname: Osman
authors.forename: Rusli
authors.initials: R
authors.lastname: Ismail
authors.forename: Tan Soo
authors.initials: TS
authors.lastname: Choon
authors.forename: Yeong Keng
authors.initials: YK
authors.lastname: Yoon
authors.forename: Ang Chee
authors.initials: AC
authors.lastname: Wei
authors.forename: Suresh
authors.initials: S
authors.lastname: Pandian
authors.forename: Elumalai
authors.initials: E
authors.lastname: Manogaran
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
chemical_list: D002800:Cholinesterase Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D000110:Acetylcholinesterase