title: Olfactory cortex generates synchronized top-down inputs to the olfactory bulb during slow-wave sleep.
abstract: The olfactory cortex is functionally isolated from the external odor world during slow-wave sleep. However, the neuronal activity pattern in the olfactory cortex and its functional roles during slow-wave sleep are not well understood. Here, we demonstrate in freely behaving rats that the anterior piriform cortex, a major area of the olfactory cortex, repeatedly generates sharp waves that are accompanied by synchronized discharges of numerous cortical neurons. Olfactory cortex sharp waves occurred relatively independently of hippocampal sharp waves. Current source density analysis showed that sharp wave generation involved the participation of recurrent association fiber synapses to pyramidal cells in the olfactory cortex. During slow-wave sleep, the olfactory bulb showed sharp waves that were in synchrony with olfactory cortex sharp waves, indicating that olfactory cortex sharp waves drove synchronized top-down inputs to the olfactory bulb. Based on these results, we speculate that the olfactory cortex sharp waves may play a role in the reorganization of bulbar neuronal circuits during slow-wave sleep.
authors.affiliation: Department of Physiology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Manabe
authors.forename: Ikue
authors.initials: I
authors.lastname: Kusumoto-Yoshida
authors.forename: Mizuho
authors.initials: M
authors.lastname: Ota
authors.forename: Kensaku
authors.initials: K
authors.lastname: Mori
mesh_terms: D000758:Anesthesia; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D058256:Brain Waves / Q000187:drug effects / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D006624:Hippocampus / Q000502:physiology; D008297:Male; D009474:Neurons / Q000502:physiology; D009830:Olfactory Bulb / Q000502:physiology*; D009833:Olfactory Pathways / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D012890:Sleep / Q000502:physiology*; D014520:Urethane / Q000494:pharmacology
chemical_list: D014520:Urethane