title: [Venovenous hemodiafiltration for patient with baclofen intoxication].
abstract: Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.
authors.affiliation: Anæstesiafdelingen, Bispebjerg Hospital, Denmark. simonuhl@hotmail.com
authors.forename: Simon Uhl
authors.initials: SU
authors.lastname: Nielsen
authors.forename: Tejs
authors.initials: T
authors.lastname: Jansen
authors.forename: Sys Stybe
authors.initials: SS
authors.lastname: Johansen
authors.forename: Kristian
authors.initials: K
authors.lastname: Linnet
authors.forename: Peter
authors.initials: P
authors.lastname: Gregersen
authors.forename: Lotte Christine Groth
authors.initials: LC
authors.lastname: Høgberg
mesh_terms: D001418:Baclofen / Q000493:pharmacokinetics / Q000506:poisoning*; D062787:Drug Overdose / Q000378:metabolism / Q000628:therapy; D006207:Half-Life; D006440:Hemofiltration; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000493:pharmacokinetics / Q000506:poisoning*; D013406:Suicide, Attempted; D055815:Young Adult
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen