title: Hodgkin's lymphoma--long-term outcome: an experience from a tertiary care cancer center in North India.
abstract: Limited information is available from developing countries on long-term outcome of patients with Hodgkin's lymphoma (HL). Between January 1998 and December 2005, 262 patients (age ≥15 years) underwent treatment. Patients' median age was 30 years, ranging from 15 to 72 years. Male to female ratio was 2.8:1. B symptoms were present in 64% of patients. Seventy percent of patients had stage III and IV disease. Mixed cellularity (52.3%) was the most common histology followed by nodular sclerosis (38%). ABVD chemotherapy was used in 85% of the patients, and 50% received radiotherapy as consolidation. Following treatment 92% of patients achieved complete response. Five-year freedom from treatment failure (FFTF) and overall survival rate are 78.3% and 86.6% ± 0.02% (95% CI 80.0-93.2%), respectively. Stage at presentation, number of lymph node regions involved (≥3 vs ≤2), presence of B symptoms, and serum albumin (≥40 vs <40 g/L) were important determinants of FFTF. In a subset analysis of stage I and II HL patients, presence of bulky disease and pure infradiaphragmatic disease was associated with inferior outcome. On multivariate analysis involvement of three or more number of lymph node regions was a significant predictor of inferior freedom from treatment failure survival (hazard ratio 2.2, p < 0.01). Our analysis confirms excellent outcome for patients of Hodgkin's lymphoma with results comparable to developed countries.
authors.affiliation: Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Prasanth
authors.initials: P
authors.lastname: Ganesan
authors.forename: Lalit
authors.initials: L
authors.lastname: Kumar
authors.forename: Vinod
authors.initials: V
authors.lastname: Raina
authors.forename: Atul
authors.initials: A
authors.lastname: Sharma
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
authors.forename: Vishnubhatla
authors.initials: V
authors.lastname: Sreenivas
authors.forename: Malini
authors.initials: M
authors.lastname: Vijayaraghavan
authors.forename: Sanjay
authors.initials: S
authors.lastname: Thulkar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003906:Developing Countries; D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D006779:Hospitals, Public; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010044:Outpatient Clinics, Hospital; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D000075462:Serum Albumin, Human; D017678:Sex Distribution; D016019:Survival Analysis; D055815:Young Adult
chemical_list: C422455:ALB protein, human; D012709:Serum Albumin; D000075462:Serum Albumin, Human