title: Surgical therapy of peri-implantitis lesions by means of a bovine-derived xenograft: comparative results of a prospective study on two different implant surfaces.
abstract: OBJECTIVE
  The aim of this prospective study was to evaluate a regenerative surgical treatment modality for peri-implantitis lesions on two different implant surfaces.
  
  
  METHODS
  Twenty-six patients with one crater-like defect, around either TPS (Control) or SLA (Test) dental implants, with a probing depth (PD) ≥6 mm and no implant mobility, were included. The implant surface was mechanically debrided and treated using a 24% EDTA gel and a 1% chlorhexidine gel. The bone defect was filled with a bovine-derived xenograft (BDX) and the flap was sutured around the non-submerged implant.
  
  
  RESULTS
  One-year follow-up demonstrated clinical and radiographic improvements. PDs were significantly reduced by 2.1±1.2 mm in the Control implants and by 3.4±1.7 mm in the Test implants. Complete defect fill was never found around Controls, while it occurred in three out of 12 Test implants. Bleeding on probing decreased from 91.1±12.4% (Control) and 75.0±30.2% (Test) to 57.1±38.5% (p=0.004) and 14.6±16.7% (p=0.003), respectively. Several deep pockets (≥6 mm) were still present after surgical therapy around Controls.
  
  
  CONCLUSIONS
  Surface characteristics may have an impact on the clinical outcome following surgical debridement, disinfection of the contaminated surfaces and grafting with BDX. Complete fill of the bony defect seems not to be a predictable result.
authors.affiliation: Department of Maxillo-Facial Surgery, University of Torino, Torino, Italy. mroccuzzo@iol.it
authors.forename: Mario
authors.initials: M
authors.lastname: Roccuzzo
authors.forename: Francesca
authors.initials: F
authors.lastname: Bonino
authors.forename: Luca
authors.initials: L
authors.lastname: Bonino
authors.forename: Paola
authors.initials: P
authors.lastname: Dalmasso
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D000368:Aged; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000737:chemistry; D001857:Bone Matrix / Q000637:transplantation*; D002417:Cattle; D002710:Chlorhexidine / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D045662:Dental Etching / Q000379:methods; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry; D017267:Dental Prosthesis Design; D004492:Edetic Acid / Q000737:chemistry; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000145:classification / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D057873:Peri-Implantitis / Q000601:surgery*; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D058626:Plasma Gases / Q000737:chemistry; D011446:Prospective Studies; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry; D014183:Transplantation, Heterologous; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; C077540:Bio-Oss; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D003764:Dental Materials; D008903:Minerals; D058626:Plasma Gases; D004492:Edetic Acid; D014025:Titanium; D002710:Chlorhexidine