title: Risperidone treatment for polydipsia and hyponatremia in schizophrenia: a case report.
abstract: Psychogenic polydipsia with associated hyponatremia is a potentially fatal condition observed in patients with chronic psychiatric illness, especially schizophrenia. Recognition and management of this condition are difficult, as patients are uncooperative and secretive about their water intake, but are important in terms of the associated complications. Different strategies, including involuntary fluid restriction and use of various pharmacological agents, such as demeclocycline, propranolol, captopril, and naloxone, have been used for the treatment of this condition with inconsistent results. Antipsychotics have also been used in the treatment of polydipsia; however, their role is not clear as there are reports of antipsychotics both improving and causing polydipsia. Typical antipsychotics have been associated with exacerbation of polydipsia, whereas clozapine has been associated with its improvement. The efficacy of risperidone in the treatment of this condition is controversial, as negative results have been reported. Herein we present a schizophrenia case with polydipsia and hyponatremia that was successfully treated with risperidone.
authors.affiliation: National Institute of Mental Health and Neurosciences, Department of Psychiatry, Bangalore, India.
authors.forename: Naren
authors.initials: N
authors.lastname: Rao
authors.forename: Ganesan
authors.initials: G
authors.lastname: Venkatasubramanian
authors.forename: Vinayak
authors.initials: V
authors.lastname: Korpade
authors.forename: Rishikesh
authors.initials: R
authors.lastname: Behere
authors.forename: Shivarama
authors.initials: S
authors.lastname: Varambally
authors.forename: Bangalore
authors.initials: B
authors.lastname: Gangadhar
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy* / Q000209:etiology; D009765:Obesity / Q000150:complications; D059607:Polydipsia, Psychogenic / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone