title: Association between the presence of brown adipose tissue and non-alcoholic fatty liver disease in adult humans.
abstract: BACKGROUND
  The presence of active brown adipose tissue (BAT) has been associated with a reduced risk of obesity in adult humans.
  
  
  OBJECTIVE
  To examine whether the presence and activity of BAT in patients undergoing PET-CT examinations is related to the presence of fatty liver.
  
  
  METHODS
  We retrospectively analysed 3666 consecutive PET-CT whole-body scans performed on a total of 1832 patients who were referred for suspected malignancies. BAT-positive subjects (BAT+) were defined as subjects who showed substantial amounts of brown adipose tissue on PET-CT scans. In areas where uptake of [(18)F]FDG was identified by CT for BAT, the maximal standardised uptake values (SUVmax), defined as the maximum activity per millilitre within the region of interest divided by the injected dose in megabecquerels per gram of body weight, were determined. A ratio of mean liver attenuation to spleen attenuation <0.8 on CT scans was considered to indicate NAFLD.
  
  
  RESULTS
  Thirty patients of the 1832 screened individuals (2%) demonstrated brown fat uptake (BAT+ subjects). Ninety matched individuals without evidence of BAT on PET scans (BAT- subjects) were enrolled for comparison purposes. After adjustment for potential confounders, the odds ratio for having NAFLD was significantly higher for BAT- subjects (3.12, 95% confidence interval = 1.03-9.88, P < 0.05). The SUVmax for brown fat tissue was significantly correlated with the ratio of mean liver attenuation to spleen attenuation (P < 0.05).
  
  
  CONCLUSIONS
  The presence of brown adipose tissue in adulthood is independently associated with a lower likelihood of NAFLD diagnosed by CT findings.
authors.affiliation: Department of Gastroenterology, Marmara University, School of Medicine, Pendik, Istanbul, Turkey. yusufyilmaz@uludag.edu.tr
authors.forename: Y
authors.initials: Y
authors.lastname: Yilmaz
authors.forename: T
authors.initials: T
authors.lastname: Ones
authors.forename: T
authors.initials: T
authors.lastname: Purnak
authors.forename: S
authors.initials: S
authors.lastname: Ozguven
authors.forename: R
authors.initials: R
authors.lastname: Kurt
authors.forename: O
authors.initials: O
authors.lastname: Atug
authors.forename: H T
authors.initials: HT
authors.lastname: Turoglu
authors.forename: N
authors.initials: N
authors.lastname: Imeryuz
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D065626:Non-alcoholic Fatty Liver Disease; D016017:Odds Ratio; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18