title: Myocardial BOLD imaging at 3 T using quantitative T2: application in a myocardial infarct model.
abstract: Left ventricular remodeling as a result of acute myocardial infarction (AMI) is associated with significant morbidity, leading to cardiovascular dysfunction, disability, and death. Despite successful revascularization, coronary vasodilatory dysfunction has been shown in infarcted and remote myocardium of patients following AMI. Our study explored the utility of a T(2)-based blood-oxygen-level-dependent approach in probing regional and longitudinal fluctuations in vasodilatory function in a porcine model of AMI at 3 T. Ten pigs underwent MRI in control state and at day 2, weeks 1-6 following 90 min occlusion followed by reperfusion. The remote myocardium exhibited vasodilatory dysfunction at weeks 1 and 2 that gradually recovered, whereas the infarct zone showed no vasodilatory alterations. Our study suggests that microvascular alterations occurring in infarcted and remote myocardium after AMI might serve as an indicator of adverse left ventricular remodeling. The blood-oxygen-level-dependent technique using quantitative T(2) could potentially be a useful noninvasive tool to evaluate novel therapeutic strategies aimed at limiting vasoconstriction and improving coronary flow reserve after AMI.
authors.affiliation: Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. nghugre@sri.utoronto.ca.
authors.forename: Nilesh R
authors.initials: NR
authors.lastname: Ghugre
authors.forename: Venkat
authors.initials: V
authors.lastname: Ramanan
authors.forename: Mihaela
authors.initials: M
authors.lastname: Pop
authors.forename: Yuesong
authors.initials: Y
authors.lastname: Yang
authors.forename: Jennifer
authors.initials: J
authors.lastname: Barry
authors.forename: Beiping
authors.initials: B
authors.lastname: Qiang
authors.forename: Kim A
authors.initials: KA
authors.lastname: Connelly
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Dick
authors.forename: Graham A
authors.initials: GA
authors.lastname: Wright
mesh_terms: D000818:Animals; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications*; D055414:Myocardial Perfusion Imaging / Q000379:methods; D010100:Oxygen / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000209:etiology*
chemical_list: D010100:Oxygen