title: Hormonal repression of miRNA biosynthesis through a nuclear steroid hormone receptor.
abstract: The maturation of primary microRNAs (pri-miRNAs) to precursor miRNAs (pre-miRNAs) is mediated by the "microprocessor" complex minimally comprimising two core components, Drosha and DGCR8. However, the roles of RNA-binding proteins associated with these core units in the large Drosha complex remain to be defined. While signal-dependent regulation of miRNA biogenesis is assumed, such regulation remains to be described. Here, we provide a short review based on our recent findings of hormonally-regulated pri-miRNA processing by nuclear estrogen receptor.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-0032, Japan.
authors.forename: Sally
authors.initials: S
authors.lastname: Fujiyama-Nakamura
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yamagata
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Kato
mesh_terms: D000818:Animals; D053487:DEAD-box RNA Helicases / Q000502:physiology; D004967:Estrogens / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis*; D011960:Receptors, Estrogen / Q000502:physiology*; D043244:Ribonuclease III / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
chemical_list: D004967:Estrogens; D035683:MicroRNAs; D011960:Receptors, Estrogen; D042461:Vascular Endothelial Growth Factor A; C517918:DROSHA protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases