title: Acute psychopathology as a predictor of global functioning in patients with ICD-10 non-affective psychosis: a prospective study in 11 European countries.
abstract: This prospective analysis aimed to study the influence of psychopathological dimensions on the global functioning of persons suffering from psychotic disorders, taking into account the role of a broad range of potential confounders. A large international cohort (n=1888) with ICD-10 non-affective psychosis was evaluated both at baseline during a hospital admission and three months after discharge. Trained interviewers administered a global functioning scale (GAF) and a psychopathological scale (BPRS) at baseline and follow-up). Baseline BPRS psychopathological dimensions were extracted using Principal Component Analysis. Results of multiple linear regression analyses demonstrated that affective symptoms (depressive or manic) prospectively predict a better global functioning, whilst agitation/cognitive symptoms determined poorer global functioning. Other predictors showing an independent effect on better global functioning were medication compliance, country of residence, female gender, married or coupled status, younger age and having a diagnosis of schizoaffective disorder rather than schizophrenia or other ICD-10 psychosis. A predicting model for global functioning in patients with psychosis is provided, showing that assessment of affective and agitation/cognitive symptoms should be emphasised during admission as they can be more informative than positive/negative symptoms in prospectively planning follow-up care that is geared towards a better functional recovery.
authors.affiliation: CIBERSAM, Section of Psychiatry and Medical Psychology, Institute of Neurosciences, Faculty of Medicine, University of Granada, Spain.
authors.forename: Eleni
authors.initials: E
authors.lastname: Petkari
authors.forename: Ana M
authors.initials: AM
authors.lastname: Salazar-Montes
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Kallert
authors.forename: Stefan
authors.initials: S
authors.lastname: Priebe
authors.forename: Andrea
authors.initials: A
authors.lastname: Fiorillo
authors.forename: Jiří
authors.initials: J
authors.lastname: Raboch
authors.forename: Georgi
authors.initials: G
authors.lastname: Onchev
authors.forename: Anastasia
authors.initials: A
authors.lastname: Karastergiou
authors.forename: Alexander
authors.initials: A
authors.lastname: Nawka
authors.forename: Algirdas
authors.initials: A
authors.lastname: Dembinskas
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kiejna
authors.forename: Lars
authors.initials: L
authors.lastname: Kjellin
authors.forename: Francisco
authors.initials: F
authors.lastname: Torres-González
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Cervilla
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D038801:International Classification of Diseases / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D025341:Principal Component Analysis; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011599:Psychopathology; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D012189:Retrospective Studies; D055815:Young Adult