title: Intravenous calcium infusion as a novel preventive therapy of ovarian hyperstimulation syndrome for patients with polycystic ovarian syndrome.
abstract: OBJECTIVE
  To evaluate the effectiveness of IV calcium infusion on prevention of ovarian hyperstimulation syndrome (OHSS) in patients with polycystic ovary syndrome undergoing assisted reproductive techniques cycles.
  
  
  METHODS
  A retrospective comparative study.
  
  
  METHODS
  Assisted reproduction techniques centre in Turkey.
  
  
  METHODS
  Four hundred fifty-five women with high risk for OHSS.
  
  
  METHODS
  The patients in group I (n = 84) were administered IV calcium gluconate for prevention of OHSS, and the patients in group II (n = 371) comprised the control group, with no manipulation for prevention of OHSS and were age- and body mass index-matched with the study group.
  
  
  METHODS
  Ovarian hyperstimulation syndrome rate, clinical pregnancy rate.
  
  
  RESULTS
  Mean (±SD) ages of the women in the calcium infusion group (group I) and the control group (group II) were comparable (30.5 ± 4.3 vs. 31.4 ± 3.9, respectively). Ovarian hyperstimulation syndrome was found in 16.2% (60 patients) in group II, whereas in group I, only 3 patients (3.6%) developed OHSS. Interestingly, all the hyperstimulation cases in group I were mild, and there was no severe effect. Implantation rates were similar in both groups. Furthermore, we obtained clinical pregnancy in nearly 40.5% in group I and 28.8% in group II. The live-birth rate was 38.1% in the calcium infusion group and 24.8% in the control group.
  
  
  CONCLUSIONS
  Intravenous calcium infusion resulted in a significantly lower rate of development of OHSS for patients with polycystic ovary syndrome and high risk of OHSS. This novel therapy may be used for prevention of OHSS effectively.
authors.affiliation: Gurgan Clinic Women Health, Infertility and IVF Center, Ankara, Turkey.
authors.forename: Timur
authors.initials: T
authors.lastname: Gurgan
authors.forename: Aygul
authors.initials: A
authors.lastname: Demirol
authors.forename: Suleyman
authors.initials: S
authors.lastname: Guven
authors.forename: Moncef
authors.initials: M
authors.lastname: Benkhalifa
authors.forename: Bagdagul
authors.initials: B
authors.lastname: Girgin
authors.forename: Tin Chiu
authors.initials: TC
authors.lastname: Li
mesh_terms: D000328:Adult; D002125:Calcium Gluconate / Q000008:administration & dosage*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology / Q000517:prevention & control*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects; D012189:Retrospective Studies
chemical_list: D002125:Calcium Gluconate