title: Clinical implications for girdin protein expression in breast cancer.
abstract: Girdin is highly expressed in breast carcinomas. Suppression of Girdin inhibited breast cancer cell migration. However, the clinical implications of Girdin as a marker are still unclear. Here we examined 80 breast cancer specimens using immunohistochemistry. Overall, positive Girdin staining was 41.25% in all of the cases. Girdin was strongly expressed in tumors of CerbB2-positive breast cancers (p < .05). Cases with both CerbB2- and Girdin-positive expression had a higher histological grade than the others. These findings indicated the closed relationship between breast cancer progression and Girdin expression. Girdin together with CerbB2 might be a new potential marker for breast cancers.
authors.affiliation: Department of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ling
authors.forename: Ping
authors.initials: P
authors.lastname: Jiang
authors.forename: Su-Ping
authors.initials: SP
authors.lastname: Cui
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Ren
authors.forename: Sai-Nan
authors.initials: SN
authors.lastname: Zhu
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Yang
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008840:Microfilament Proteins / Q000032:analysis*; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D033921:Vesicular Transport Proteins / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D008840:Microfilament Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D033921:Vesicular Transport Proteins; C502451:CCDC88A protein, human; C508053:ERBB2 protein, human