title: Comparison on gestation and lactation exposure of perfluorinated compounds for newborns.
abstract: Perfluorinated compounds (PFCs) are worldwide present in the environment and the general population. Animal studies have shown developmental toxicity of these compounds. To investigate the PFCs exposure of neonates from mother during gestation and lactation, we analyzed twelve PFCs in matched maternal serum, cord serum and breast milk samples collected from 50 pairs of women and their newborns between June and July 2009 in Jinhu, China. Eight PFCs were detected in serum samples, and five of them were also detectable in breast milk. A significant intercorrelation between PFCs concentrations in matched maternal serum, cord serum and breast milk was observed (p<0.01, r=0.435-0.911). The median partition ratio was from 0.39:1 (PFDA) to 1.74:1 (PFTrDA) for seven PFCs through the placenta, and was from 0.02:1 (PFOS) to 0.09:1 (PFOA) for five PFCs through the lactation. A high transport efficiency of PFOA both through placental barrier and lactation was observed. The postnatal exposure of PFCs through lactation was higher compared to prenatal exposure, especially for PFOA.
authors.affiliation: Key Laboratory of Chemical Safety and Health, National Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing, 100050, China.
authors.forename: Jiaying
authors.initials: J
authors.lastname: Liu
authors.forename: Jingguang
authors.initials: J
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Hing Man
authors.initials: HM
authors.lastname: Chan
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zongwei
authors.initials: Z
authors.lastname: Cai
authors.forename: Yongning
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000328:Adult; D017738:Alkanesulfonic Acids / Q000097:blood; D001942:Breast Feeding / Q000706:statistics & numerical data*; D002210:Caprylates / Q000097:blood; D002681:China; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005466:Fluorocarbons / Q000032:analysis / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007774:Lactation / Q000097:blood*; D008297:Male; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D008895:Milk, Human / Q000737:chemistry*; D011247:Pregnancy
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D004785:Environmental Pollutants; D005466:Fluorocarbons; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid