title: New developments in aminoglycoside therapy and ototoxicity.
abstract: After almost seven decades in clinical use, aminoglycoside antibiotics still remain indispensible drugs for acute infections and specific indications such as tuberculosis or the containment of pseudomonas bacteria in patients with cystic fibrosis. The review will describe the pathology and pathophysiology of aminoglycoside-induced auditory and vestibular toxicity in humans and experimental animals and explore contemporary views of the mechanisms of cell death. It will also outline the current state of protective therapy and recent advances in the development of aminoglycoside derivatives with low toxicity profiles for antimicrobial treatment and for stop-codon suppression in the attenuation of genetic disorders.
authors.affiliation: Kresge Hearing Research Institute, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5616, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.forename: Andra E
authors.initials: AE
authors.lastname: Talaska
authors.forename: Jochen
authors.initials: J
authors.lastname: Schacht
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects* / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000737:chemistry; D001306:Auditory Pathways / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D016923:Cell Death / Q000187:drug effects; D015195:Drug Design; D034381:Hearing Loss / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D015394:Molecular Structure; D018570:Risk Assessment; D012307:Risk Factors; D013329:Structure-Activity Relationship; D014722:Vestibule, Labyrinth / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents