title: Effects of vitamin E on reproductive hormones and testis structure in chronic dioxin-treated mice.
abstract: The purpose of this study was to investigate the effects of vitamin E on reproductive hormones and testis structure in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Five experimental groups of a combination of TCDD and vitamin E were designed as follows: 0 ng/kg/d and 0 mg/kg/d (control group), 100 ng/kg/d and 0 mg/kg/d (Group I), 100 ng/kg/d and 20 mg/kg/d (Group II), 100 ng/kg/d and 100 mg/kg/d (Group III), and 100 ng/kg/d and 500 mg/kg/d (Group IV) respectively. Vitamin E and TCDD were given by oral gavage for 7 weeks. The results demonstrated that TCDD decreased the levels of brain gonadotropin releasing hormone (GnRH), testis luteinizing hormone (LH) and follicle stimulating hormone (FSH), serum testosterone and testis spermatozoa number, and damaged testis structure. Vitamin E at 20 mg/kg alleviated the decrease of GnRH; vitamin E at 20, 100, and 500 mg/kg antagonized the decline of LH and FSH; vitamin E at 20 and 100 mg/kg reversed the decrease of testosterone and spermatozoa number; and vitamin E at 100 mg/kg decreased the damage of the testis structure caused by TCDD. The results indicate that vitamin E antagonizes the reproductive endocrine toxicity and alleviates the changes in testicular structure caused by TCDD.
authors.affiliation: Department of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
authors.forename: Hai-Ping
authors.initials: HP
authors.lastname: Yin
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Xu
authors.forename: Xian-Qing
authors.initials: XQ
authors.lastname: Zhou
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001923:Brain Chemistry; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006651:Histocytochemistry; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051379:Mice; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013739:Testosterone / Q000097:blood*; D036401:Toxicity Tests, Chronic; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D000072317:Polychlorinated Dibenzodioxins; D014810:Vitamin E; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone