title: [Antihypertensive and nephroprotective effectiveness of AT1-angiotensin II receptor blocker valsartan in average therapeutic and maximal daily dose in patients with arterial hypertension and chronic kidney disease].
abstract: The results of the study which show efficiency of an antihypertensive and nephroprotective angiotensin II receptor blocker valsartan in patients with arterial hypertension of and chronic kidney disease are presented. Dose dependence of nephroprotective and antihypertensive effects of valsartan is demonstrated as well as high safety profile of the drug in average and maximal therapeutic doses.
authors.forename: M A
authors.initials: MA
authors.lastname: Maksimov
authors.forename: E A
authors.initials: EA
authors.lastname: Derbentseva
authors.forename: O V
authors.initials: OV
authors.lastname: Dralova
authors.forename: A K
authors.initials: AK
authors.lastname: Starodubtsev
authors.forename: O D
authors.initials: OD
authors.lastname: Ostroumova
mesh_terms: D000284:Administration, Oral; D000368:Aged; D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects*; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism; D012720:Severity of Illness Index; D013777:Tetrazoles / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome; D014633:Valine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D000068756:Valsartan; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D044140:Receptor, Angiotensin, Type 1; D013777:Tetrazoles; D000068756:Valsartan; D014633:Valine