title: Long-term antihypertensive effect of angiotensin-converting enzyme inhibitory peptide LAP.
abstract: OBJECTIVE
  To study the antihypertensive effects of the angiotensin-converting enzyme (ACE)-inhibitory peptide LAP on blood pressure in spontaneously hypertensive rats (SHRs).
  
  
  METHODS
  A cohort of 12-week-old SHRs was randomly divided into 2 distinct groups, and ACE-inhibitory peptide LAP (experimental group) or physiological saline (controls) were administered. Caudal arterial blood pressure was then measured at specific time points (0, 4, 8 and 12 weeks).
  
  
  RESULTS
  Systolic blood pressure of the SHRs showed a significant decrease after intraperitoneal injection with the ACE-inhibitory peptide LAP. Moreover, this depressurization effect lasted for over 1 month.
  
  
  CONCLUSIONS
  Systolic blood pressure of SHRs could effectively be depressed in the long term by antihypertensive activity mediated by the ACE-inhibitory peptide LAP.
authors.affiliation: Department of Cardiology, Affiliated Tongji Hospital of Tongji University, Shanghai, PR China.
authors.forename: Luo
authors.initials: L
authors.lastname: Ming
authors.forename: Shen
authors.initials: S
authors.lastname: Yi
authors.forename: Liu
authors.initials: L
authors.lastname: Chi
authors.forename: Huan
authors.initials: H
authors.lastname: Zheng
authors.forename: Zhanxia
authors.initials: Z
authors.lastname: Li
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Deng
authors.forename: Junlin
authors.initials: J
authors.lastname: Huang
authors.forename: Lingxia
authors.initials: L
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Fang
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D015331:Cohort Studies; D006973:Hypertension / Q000188:drug therapy* / Q000201:enzymology*; D008297:Male; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D010455:Peptides