title: Color of meconium and interleukin-6.
abstract: OBJECTIVE
  To test the hypothesis that the color of meconial fluid is associated with inflammatory biomarkers, by determining C-reactive protein (CRP) and Interleukin-6 (IL-6) in serum from the umbilical cord.
  
  
  METHODS
  In this prospective study, the authors selected 30 newborns with meconium-stained amniotic fluid (MSAF): 14 with green/brown 656 R color and 16 with brown/cinnamon 654 R color, and 20 newborns which showed clear amniotic fluid without MSAF (non-MSAF); all newborns were from mothers without risk factors for neonatal sepsis.
  
  
  RESULTS
  IL-6 concentration from umbilical cord blood, [median of 12.9 pg/mL (interquartile range {IQR} 8.7-31.0)] of MSAF-green/brown 656 R increased significantly (p < 0.05) when compared with IL-6 concentration, [median of 9.2 pg/mL (IQR 7.2-12.2)] of newborns with clear amniotic fluid and without meconium. CRP from MSAF-green/brown 656 R was median of 0.5 mg/mL (IQR 0.0-2.7), and median of 1.0 mg/mL (IQR 0.0-5.5) from clear amniotic fluid, without meconium.
  
  
  CONCLUSIONS
  Significant association was found between MSAF-green/brown 656 R and increase in IL-6, with normal CRP values.
authors.affiliation: Hospital General "Dr. Aurelio Valdivieso", Servicios de Salud del Estado de Oaxaca, Oaxaca, Mexico.
authors.forename: Raquel
authors.initials: R
authors.lastname: Silva-Bravo
authors.forename: Gabriel
authors.initials: G
authors.lastname: Mayoral-Andrade
authors.forename: Edgar
authors.initials: E
authors.lastname: Zenteno
authors.forename: Pedro
authors.initials: P
authors.lastname: Hernandez
authors.forename: Ruth
authors.initials: R
authors.lastname: Martínez-Cruz
authors.forename: Laura Perez-Campos
authors.initials: LP
authors.lastname: Mayoral
authors.forename: Sergio
authors.initials: S
authors.lastname: Aguilar-Ruiz
authors.forename: Alberto
authors.initials: A
authors.lastname: Paz-Pacheco
authors.forename: Romeo
authors.initials: R
authors.lastname: Zarate-Aspiros
authors.forename: Magdalena
authors.initials: M
authors.lastname: López-Bravo
authors.forename: Yuri
authors.initials: Y
authors.lastname: Roldan-Aragon
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pérez-Campos
mesh_terms: D000653:Amniotic Fluid; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D003116:Color; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008470:Meconium / Q000737:chemistry*; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein