title: [Clinical and etiopathogenetic role of plasminogen and metaloproteinase systems in the tumor growth. Pericellular proteolysis of extracellular matrix and tumor growth].
abstract: Pericellular proteolysis is a cascade process involved in degradation of extracellular matrix. This process is included in various physiological and pathological processes. Pericellullar proteolysis has major functions like degradation of tissue stroma and weakening of intercellular connections but it also has a function in the synthesis of bioactive molecules (cytokines, growth factors and inhibitory factors). Plasminogen system is involved in fibrinolysis and starts metalloproteinase activation. Activity of proteolytic molecules is controlled by the rate of zymogenic activation, half-life of molecules, and action of inhibitory molecules. Inhibition is achieved through direct binding of inhibitor and enzyme and takes a few steps. Pericellular proteolysis is involved in tumor invasion and metastasis, inflammatory reaction, degenerative diseases and other diseases. Pathophysiological regulation of pericellular proteolysis in mentioned diseases contributes to clinical properties of diseases and has diagnostic and therapeutic importance.
authors.affiliation: Zavod za patofiziologiju Medicinskog fakulteta Sveucilista u Zagrebu, KBC Zagreb.
authors.forename: Sanda Jelisavac
authors.initials: SJ
authors.lastname: Cosić
authors.forename: Zdenko
authors.initials: Z
authors.lastname: Kovac
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D045726:Metalloproteases / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology*; D010958:Plasminogen / Q000502:physiology*; D010960:Plasminogen Activators / Q000502:physiology
chemical_list: D010958:Plasminogen; D045726:Metalloproteases; D010960:Plasminogen Activators