title: RAS and Hedgehog--partners in crime.
abstract: Both RAS and Hedgehog (HH) pathway activation can be found in approximately one third of all cancers. In many cases, this activation occurs in the same tumor types, suggesting a positive impact of a simultaneous activation of RAS and HH on tumor development. This review aims to summarize the current knowledge about the molecular and functional crosstalk of RAS and HH signaling in the development of hyperproliferative disease.
authors.affiliation: Institute of Molecular Biology and Tumor Research (IMT), Philipps University, 35037 Marburg, Germany. lauth@imt.unimarburg.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Lauth
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D011905:Genes, ras; D053823:Hedgehog Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D025941:Protein Interaction Mapping; D015398:Signal Transduction; D018631:ras Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D053823:Hedgehog Proteins; D018631:ras Proteins