title: The role of memory-related gene polymorphisms, KIBRA and CLSTN2, on replicate memory assessment in the elderly.
abstract: The role of the CLSTN2 (rs6439886) and KIBRA (rs17070145) SNPs in cognitive impairment was analysed in a 75-76 years old group. Various memory assessment tests were carried out on individuals at baseline and during follow-up investigations, and biallelic genotyping was performed. No influence of the allele status of either SNPs was observed on any memory test. No increased risk of any type of late development, and cognitive impairment was associated with rs6439886 or rs17070145.
authors.affiliation: Department of Clinical Chemistry and Laboratory Medicine, Danube Hospital, Langobardenstr. 122, 1220 Vienna, Austria. Nazanin.sedille-mostafaie@wienkav.at
authors.forename: N
authors.initials: N
authors.lastname: Sédille-Mostafaie
authors.forename: C
authors.initials: C
authors.lastname: Sebesta
authors.forename: K R
authors.initials: KR
authors.lastname: Huber
authors.forename: S
authors.initials: S
authors.lastname: Zehetmayer
authors.forename: S
authors.initials: S
authors.lastname: Jungwirth
authors.forename: K H
authors.initials: KH
authors.lastname: Tragl
authors.forename: P
authors.initials: P
authors.lastname: Fischer
authors.forename: W
authors.initials: W
authors.lastname: Krugluger
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics*; D000544:Alzheimer Disease / Q000175:diagnosis; D001317:Austria; D002135:Calcium-Binding Proteins / Q000235:genetics*; D060825:Cognitive Dysfunction / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008568:Memory; D009483:Neuropsychological Tests; D010750:Phosphoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C472551:CLSTN2 protein, human; D002135:Calcium-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D010750:Phosphoproteins; C513637:WWC1 protein, human