title: Triterpenoids from the roots of Sanguisorba tenuifolia var. Alba.
abstract: The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC₅₀ values in the 0.62-3.62 mM range.
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China. hxkuang@hotmail.com
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Li
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Wang
authors.forename: Bing-You
authors.initials: BY
authors.lastname: Yang
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Wang
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Xia
mesh_terms: D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D031993:Sanguisorba / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D014315:Triterpenes