title: Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney.
abstract: Pituitary adenylate cyclase activating polypeptide (PACAP) is a widespread neuropeptide with diverse effects in the nervous system and peripheral organs. One of the most well-studied effects of PACAP is its cytoprotective action, against different harmful stimuli in a wide variety of cells and tissues. PACAP occurs in the urinary system, from the kidney to the lower urinary tract. The present review focuses on the nephroprotective effects of PACAP and summarizes data obtained regarding the protective effects of PACAP in different models of kidney pathologies. In vitro data show that PACAP protects tubular cells against oxidative stress, myeloma light chain, cisplatin, cyclosporine-A and hypoxia. In vivo data provide evidence for its protective effects in ischemia/reperfusion, cisplatin, cyclosporine-A, myeloma kidney injury, diabetic nephropathy and gentamicin-induced kidney damage. Results accumulated on the renoprotective effects of PACAP suggest that PACAP is an emerging candidate for treatment of human kidney pathologies.
authors.affiliation: Department of Anatomy, University of Pecs, Szigeti u 12, 7624 Pecs, Hungary. dora.reglodi@aok.pte.hu
authors.forename: Dora
authors.initials: D
authors.lastname: Reglodi
authors.forename: Peter
authors.initials: P
authors.lastname: Kiss
authors.forename: Gabriella
authors.initials: G
authors.lastname: Horvath
authors.forename: Andrea
authors.initials: A
authors.lastname: Lubics
authors.forename: Eszter
authors.initials: E
authors.lastname: Laszlo
authors.forename: Andrea
authors.initials: A
authors.lastname: Tamas
authors.forename: Boglarka
authors.initials: B
authors.lastname: Racz
authors.forename: Peter
authors.initials: P
authors.lastname: Szakaly
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000494:pharmacology / Q000633:toxicity; D016572:Cyclosporine / Q000633:toxicity; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D007674:Kidney Diseases / Q000378:metabolism* / Q000517:prevention & control*; D018384:Oxidative Stress / Q000187:drug effects; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000378:metabolism* / Q000494:pharmacology; D015424:Reperfusion; D014551:Urinary Tract / Q000187:drug effects / Q000201:enzymology*
chemical_list: D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D016572:Cyclosporine; D002945:Cisplatin