title: Adiponectin and lipid profiles compared with insulins in relation to early growth of British South Asian and European children: the Manchester children's growth and vascular health study.
abstract: BACKGROUND
  Adiponectin, high-density lipoprotein cholesterol (HDL-C) and insulin concentrations may be important in the pathophysiology of cardiovascular disease.
  
  
  OBJECTIVE
  We tested the hypothesis that serum adiponectin rather than insulin differs from early life, between South Asians and Europeans, with a potentially key role in excess cardiovascular risk characteristic of adult South Asians.
  
  
  METHODS
  We conducted a longitudinal study of 215 British-born children of European (n = 138) and South Asian (n = 77) origin, from birth to 3 yr.
  
  
  METHODS
  Serum adiponectin, insulin, proinsulin and HDL-C concentrations were assessed in relation to ethnic group and growth in anthropometric variables from 0-3 yr of age.
  
  
  RESULTS
  Serum adiponectin was lower in South Asian children, despite their smaller size, notable at age 3-6 months (9.5 vs. 11.8 mg/liter; P = 0.04), with no ethnic differences in serum lipids or insulin or proinsulin. In mixed-effects longitudinal models for HDL-C, determinants were adiponectin (P = 0.034), age (P < 0.001), and body mass index (P < 0.001) but not ethnicity. None of these or growth variables affected either insulin or proinsulin. In a fully adjusted mixed-effects longitudinal model including age, sex, insulin, and proinsulin, the independent determinants of serum adiponectin were height [21.3 (95% confidence interval = 31.7-10.8 cm lower, for every 1 mmol/liter increase in adiponectin, P < 0.001], HDL-C [2.8 (1.3-4.2) mmol/liter higher, P < 0.0001], body mass index (lower, P = 0.03), and South Asian ethnicity (lower, P = 0.01).
  
  
  CONCLUSIONS
  These British South Asian-origin infants have lower serum adiponectin but no differences in HDL-C or insulin molecules. In South Asians, factors affecting adiponectin metabolism in early life, rather than insulin resistance, likely determine later excess cardiovascular risk.
authors.affiliation: Cardiovascular Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.
authors.forename: Narinder
authors.initials: N
authors.lastname: Bansal
authors.forename: Simon G
authors.initials: SG
authors.lastname: Anderson
authors.forename: Avni
authors.initials: A
authors.lastname: Vyas
authors.forename: Isla
authors.initials: I
authors.lastname: Gemmell
authors.forename: Valentine
authors.initials: V
authors.lastname: Charlton-Menys
authors.forename: John
authors.initials: J
authors.lastname: Oldroyd
authors.forename: Philip
authors.initials: P
authors.lastname: Pemberton
authors.forename: Paul N
authors.initials: PN
authors.lastname: Durrington
authors.forename: Peter E
authors.initials: PE
authors.lastname: Clayton
authors.forename: J Kennedy
authors.initials: JK
authors.lastname: Cruickshank
mesh_terms: D052242:Adiponectin / Q000097:blood; D001208:Asia / Q000208:ethnology; D044466:Asian People / Q000706:statistics & numerical data*; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000378:metabolism; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood*; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007229:Infant Welfare / Q000706:statistics & numerical data; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D008297:Male; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D044465:White People / Q000706:statistics & numerical data*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides