title: A woman with premature ovarian failure induced by Tripterygium wilfordii Hook.f. gives birth to a healthy child.
abstract: OBJECTIVE
  To inform clinicians about the reproductive damage of Tripterygium wilfordii Hook.f. (TW) associated with subsequent premature ovarian failure.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Reproductive medicine center in a university-affiliated hospital.
  
  
  METHODS
  A 36-year-old infertile woman presenting amenorrhea and elevated FSH levels (65.56 mIU/mL) after using TW.
  
  
  METHODS
  Estradiol valerate, two month course of oral contraceptives, GnRH agonist, stimulation cycle with urine FSH, triggered ovulation using 5000 IU of hCG and IVF-ET.
  
  
  METHODS
  Serum hormone levels, antral follicle count (AFC), oocyte retrieval number, embryo quality and birth.
  
  
  RESULTS
  Serum hormone levels and AFC of the POF woman were restored, and she gave birth to a healthy child after IVF-ET. Through IVF-ET she was found to have had oocyte and granulosa cell damage because of TW.
  
  
  CONCLUSIONS
  This is a real-life manifestation of reproductive damage of TW. The medicamentous amenorrhea, hormone levels and AFC decline induced by TW are reversible, but oocyte and granulosa cell damage may be irreversible. This will help clinicians to avoid using TW for nulligravida.
authors.affiliation: Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Shi-Ling
authors.initials: SL
authors.lastname: Chen
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D004958:Estradiol / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D029757:Tripterygium; D014463:Ultrasonography
chemical_list: D004365:Drugs, Chinese Herbal; D004958:Estradiol