title: Peptide/laccase cocatalyzed asymmetric α-oxyamination of aldehydes.
abstract: An asymmetric α-oxyamination could be successfully performed by a peptide catalyst and laccase. The combination of peptide catalysis and enzymatic air oxidation promoted the reaction smoothly in water without employing a metal reagent. The oxyaminated compounds could be obtained as both aldehyde and carboxylic acid products depending on the reaction conditions.
authors.affiliation: Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Akagawa
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kudo
mesh_terms: D000447:Aldehydes / Q000737:chemistry* / Q000378:metabolism; D000586:Amination; D055162:Biocatalysis; D042845:Laccase / Q000378:metabolism*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D010087:Oxides; D010455:Peptides; D042845:Laccase