title: Is microencapsulation the future of probiotic preparations? The increased efficacy of gastro-protected probiotics.
abstract: In a recent publication we assessed the kinetics of intestinal colonization by microencapsulated probiotic bacteria in comparison with the same strains given in an uncoated form. It's well known, in fact, that microencapsulation of probiotics with specific materials is able to confer a significant resistance to gastric juice, thus protecting the cells during the gastric and duodenal transit and enhancing the probiotic efficacy of any supplementation. In any case, this was the first study reporting the fecal amounts of probiotics administered in a coated, protected form compared with traditional, uncoated ones. Here we discuss additional in vitro data of resistance of the same bacteria to gastric juice, human bile and pancreatic secretion and correlate them with the results of in vivo gut colonization.
authors.affiliation: Gastroenterology Unit, Maggiore della Carità Hospital, Novara, Italy. mario.delpiano@alice.it
authors.forename: Mario
authors.initials: M
authors.lastname: Del Piano
authors.forename: Stefania
authors.initials: S
authors.lastname: Carmagnola
authors.forename: Marco
authors.initials: M
authors.lastname: Ballarè
authors.forename: Massimo
authors.initials: M
authors.lastname: Sartori
authors.forename: Marco
authors.initials: M
authors.lastname: Orsello
authors.forename: Marco
authors.initials: M
authors.lastname: Balzarini
authors.forename: Michela
authors.initials: M
authors.lastname: Pagliarulo
authors.forename: Roberto
authors.initials: R
authors.lastname: Tari
authors.forename: Andrea
authors.initials: A
authors.lastname: Anderloni
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Strozzi
authors.forename: Luca
authors.initials: L
authors.lastname: Mogna
authors.forename: Filomena
authors.initials: F
authors.lastname: Sforza
authors.forename: Lucio
authors.initials: L
authors.lastname: Capurso
mesh_terms: D001419:Bacteria / Q000254:growth & development*; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D007422:Intestines / Q000382:microbiology; D050296:Microbial Viability; D019936:Probiotics / Q000008:administration & dosage*