title: The discovery of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex and the molecular regulation of synaptic vesicle transmitter release: the 2010 Kavli Prize in neuroscience.
abstract: Brain function depends on a crucial feature: The ability of individual neurons to share packets of information, known as quantal transmission. Given the sheer number of tasks the brain has to deal with, this information sharing must be extremely rapid. Synapses are specialized points of contact between neurons, where fast transmission takes place. Though the basic elements and functions of the synapse had been established since the 1950s, the molecular basis for regulation of fast synaptic transmitter release was not known 20 years ago. However, around 1990, crucial discoveries were made by Richard Scheller, James Rothman, and Thomas Südhof, leading a few years later to the formulation of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) hypothesis and a new understanding of the molecular events controlling vesicular release of transmitter in synapses. The 2010 Kavli Prize in neuroscience was awarded to these three researchers, "for their work to reveal the precise molecular basis of the transfer of signals between nerve cells in the brain."
authors.affiliation: Institute of Basic Medical Science, and Centre for Molecular Biology and Neuroscience, University of Oslo, PO Box 1105 Blindern, 0317 Oslo, Norway.
authors.forename: S
authors.initials: S
authors.lastname: Hussain
authors.forename: S
authors.initials: S
authors.lastname: Davanger
mesh_terms: D001363:Awards and Prizes; D001921:Brain / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D009446:Neurobiology / Q000266:history; D009474:Neurons / Q000378:metabolism*; D009664:Norway; D050600:SNARE Proteins / Q000266:history / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology; D013572:Synaptic Vesicles / Q000378:metabolism*; D014481:United States
chemical_list: D050600:SNARE Proteins