title: Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or race.
abstract: OBJECTIVE
  To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships.
  
  
  METHODS
  Subjects were 441 adolescents, 14-18 years old (44% black, 56% white; 50% female, 50% male). Percent body fat (%BF) was measured with dual-energy X-ray absorptiometry. Leptin and adiponectin were measured using immunoassays.
  
  
  RESULTS
  Among the four groups (white boys, white girls, black boys and black girls), white girls had the highest adiponectin (p = 0.0017) and black girls had the highest leptin (p = 0.0164). Percent BF and leptin were positively correlated (p = 0.0164). The %BF-leptin relationship was stronger in boys than girls (p < 0.0001). Those with lower adiponectin had a stronger %BF-leptin relationship than those with high adiponectin in the entire sample (p = 0.0220). Statistical models were adjusted for age, race, gender and the interaction between race and gender.
  
  
  CONCLUSIONS
  Our data suggest a protective metabolic interaction for adiponectin and lend additional support for obesity prevention strategies in adolescents.
authors.affiliation: Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Bundy
authors.forename: Maribeth
authors.initials: M
authors.lastname: Johnson
authors.forename: Bernard
authors.initials: B
authors.lastname: Gutin
authors.forename: Haidong
authors.initials: H
authors.lastname: Zhu
authors.forename: Inger
authors.initials: I
authors.lastname: Stallmann-Jorgensen
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Dong
mesh_terms: D015502:Absorptiometry, Photon; D052242:Adiponectin / Q000502:physiology*; D000273:Adipose Tissue / Q000000981:diagnostic imaging; D050154:Adiposity / Q000208:ethnology / Q000502:physiology*; D000293:Adolescent; D001741:Black or African American / Q000208:ethnology; D005260:Female; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000208:ethnology / Q000517:prevention & control; D012737:Sex Factors; D044465:White People / Q000208:ethnology
chemical_list: D052242:Adiponectin; D020738:Leptin