title: Modern PET imaging for paragangliomas: relation to genetic mutations.
abstract: OBJECTIVE
  Paragangliomas (PGL) are neural crest-derived tumours that are found along the autonomic neural network throughout the body and can be multiple and/or metastatic. Nuclear medicine imaging in combination with conventional imaging is required to fully delineate the extent of the disease. The performance of molecular imaging modalities is widely dependent on tumour biology.
  
  
  RESULTS
  In the present paper we discuss the recent publications focused on the role of positron emission tomography (PET) imaging and the relationship between tracer uptake patterns and genetic mutations associated with the disease.
  
  
  CONCLUSIONS
  Recent advances in genetic and molecular pathogenesis of PGL have allowed for the identification of new molecular diagnostic and therapeutic radiopharmaceuticals tailored to genetic abnormalities. However, the optimal diagnostic imaging algorithm remains to be determined.
authors.affiliation: Department of Nuclear Medicine, Centre hospitalo-universitaire Timone, Marseille, France.
authors.forename: D
authors.initials: D
authors.lastname: Taïeb
authors.forename: D
authors.initials: D
authors.lastname: Rubello
authors.forename: A
authors.initials: A
authors.lastname: Al-Nahhas
authors.forename: M
authors.initials: M
authors.lastname: Calzada
authors.forename: M C
authors.initials: MC
authors.lastname: Marzola
authors.forename: E
authors.initials: E
authors.lastname: Hindié
mesh_terms: D006801:Humans; D009154:Mutation; D010235:Paraganglioma / Q000000981:diagnostic imaging* / Q000235:genetics*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals