title: Age does not influence the effect of embryo fragmentation on successful blastocyst development.
abstract: We evaluated the rate of blastocyst development in day 3 embryos with appropriate cellular division and investigated whether maternal age modified the effect of embryo fragmentation on blastulation. Our data showed a significant negative correlation between the degree of embryo fragmentation and rate of blastocyst development, but age did not exert an effect on the degree of fragmentation in embryos with appropriate cleaving status, nor did it modify the significant effect embryo fragmentation had on blastocyst formation.
authors.affiliation: Center for Reproductive Health, University of Cincinnati Academic Health Center, Cincinnati, Ohio 45219, USA. dhwu88@gmail.com
authors.forename: Diana H
authors.initials: DH
authors.lastname: Wu
authors.forename: Kasey
authors.initials: K
authors.lastname: Reynolds
authors.forename: Rose
authors.initials: R
authors.lastname: Maxwell
authors.forename: Steven R
authors.initials: SR
authors.lastname: Lindheim
authors.forename: Mira
authors.initials: M
authors.lastname: Aubuchon
authors.forename: Michael A
authors.initials: MA
authors.lastname: Thomas
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000473:pathology*; D016009:Chi-Square Distribution; D002970:Cleavage Stage, Ovum / Q000473:pathology*; D046149:Embryo Culture Techniques; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008423:Maternal Age; D009820:Ohio; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult