title: Increased serum matrix metalloproteinase-9 in neuromyelitis optica: implication of disruption of blood-brain barrier.
abstract: Matrix metalloproteinase-9 (MMP-9) plays an important role in some neuroinflammatory diseases through the blood-brain barrier (BBB) disruption. To investigate the pathogenicity of MMP-9 in neuromyelitis optica (NMO), serum and CSF MMP-9 concentrations were measured in 13 NMO and 15 multiple sclerosis (MS) patients and 14 healthy controls, and correlated with clinical and laboratorial parameters. Serum MMP-9 concentrations were significantly higher in NMO than MS and controls, and correlated with EDSS score, CSF/serum albumin ratio, and CSF IL-8 concentrations. Our results indicate that MMP-9, promoted by elevated IL-8 activation, plays a crucial role in the pathogenesis of NMO through the BBB disruption.
authors.affiliation: Department of Internal Medicine I, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 568-8686, Japan. in1237@poh.osaka-med.ac.jp
authors.forename: Takafumi
authors.initials: T
authors.lastname: Hosokawa
authors.forename: Hideto
authors.initials: H
authors.lastname: Nakajima
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Doi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Sugino
authors.forename: Fumiharu
authors.initials: F
authors.lastname: Kimura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hanafusa
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier / Q000201:enzymology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood* / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid / Q000201:enzymology* / Q000503:physiopathology*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood / Q000134:cerebrospinal fluid; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019715:Tissue Inhibitor of Metalloproteinase-1; D020780:Matrix Metalloproteinase 9