title: Pharmacogenetic approaches to cognitive enhancement in schizophrenia.
abstract: Research in the area of pharmacogenetics in psychiatry is aimed at identifying clinically relevant genetic variations that can predict treatment response. Ultimately, the goal is to individualize treatment in order to optimize outcome in disorders in which incomplete treatment response is common. Positive symptoms in patients with schizophrenia appear to be the most amenable to the currently available agents; however, negative symptoms and cognitive deficits frequently persist even when frank psychosis is well controlled. Given the relationship between these persistent traits and functional disability in schizophrenia, efforts are under way to directly target cognitive impairment and negative symptoms pharmacologically in order to improve quality of life. To date, most pharmacogenetic studies of schizophrenia have been focused on predicting clinical efficacy and side effects. In this review, we discuss the potential use of cognition as a primary outcome measure of interest in future pharmacogenetic trials of schizophrenia.
authors.affiliation: Albert Einstein College of Medicine, USA. KBurdick@NSHS.edu
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Burdick
authors.forename: Chaya B
authors.initials: CB
authors.lastname: Gopin
authors.forename: Anil K
authors.initials: AK
authors.lastname: Malhotra
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D015259:Dopamine Agents / Q000627:therapeutic use; D018683:Excitatory Amino Acid Agents / Q000627:therapeutic use; D006801:Humans; D010597:Pharmacogenetics; D011954:Receptors, Dopamine / Q000235:genetics; D017470:Receptors, Glutamate / Q000235:genetics; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D015259:Dopamine Agents; D018683:Excitatory Amino Acid Agents; D011954:Receptors, Dopamine; D017470:Receptors, Glutamate