title: Nitrosyl iron complexes--synthesis, structure and biology.
abstract: Nitrosyl complexes of iron are formed in living species in the presence of nitric oxide. They are considered a form in which NO can be stored and stabilized within a living cell. Upon entering a topic in bioinorganic chemistry the researcher faces a wide spectrum of issues concerning synthetic methods, the structure and chemical properties of the complex on the one hand, and its biological implications on the other. The aim of this review is to present the newest knowledge on nitrosyl iron complexes, summarizing the issues that are important for understanding the nature of nitrosyl iron complexes, their possible interactions, behavior in vitro and in vivo, handling of the preparations etc. in response to the growing interest in these compounds. Herein we focus mostly on the dinitrosyl iron complexes (DNICs) due to their prevailing occurrence in NO-treated biological samples. This article reviews recent knowledge on the structure, chemical properties and biological action of DNICs and some mononitrosyls of heme proteins. Synthetic methods are also briefly reviewed.
authors.affiliation: Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, 16 Dorodna Str., 03-195, Warsaw, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Lewandowska
authors.forename: Monika
authors.initials: M
authors.lastname: Kalinowska
authors.forename: Kamil
authors.initials: K
authors.lastname: Brzóska
authors.forename: Karolina
authors.initials: K
authors.lastname: Wójciuk
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Wójciuk
authors.forename: Marcin
authors.initials: M
authors.lastname: Kruszewski
mesh_terms: D005982:Glutathione Transferase / Q000737:chemistry / Q000378:metabolism; D006420:Hemeproteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000737:chemistry / Q000378:metabolism*; D008511:Medicine; D009569:Nitric Oxide / Q000378:metabolism; D009589:Nitrogen Oxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D006420:Hemeproteins; D009589:Nitrogen Oxides; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D007501:Iron; D005982:Glutathione Transferase