title: Synthesis of spiro-fused pyrazolidoylisoxazolines.
abstract: Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-heterocycles. Molecular shape space diversity analyses were performed on these pyrazolidoylisoxazolines showing that manipulation of the appended R groups significantly changes the molecular shape.
authors.affiliation: Department of Chemistry, University of California, Davis, California 95616, United States.
authors.forename: Kathryn G
authors.initials: KG
authors.lastname: Guggenheim
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Butler
authors.forename: Phillip P
authors.initials: PP
authors.lastname: Painter
authors.forename: Beth A
authors.initials: BA
authors.lastname: Lorsbach
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Tantillo
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kurth
mesh_terms: D003500:Cyclization; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007555:Isoxazoles; D013141:Spiro Compounds