title: [Prognostic value of aortic stenosis in patients after acute coronary syndrome].
abstract: With the aim to assess prevalence of aortic stenosis (AS) and prognostic value of its detection among survivors of acute coronary syndrome (ACS) we examined 851 patients included into multicenter prospective study of risk factors of serious vascular events and death after acute coronary syndrome. The patients were enrolled into the study in stable condition on 10th day after onset of myocardial infarction (MI) or unstable angina (UA). Examination involved medical history, laboratory tests and echocardiography. Afterwards all cases of death and serious vascular events were registered. Severity of AS was specified by maximal aortic flow rate: 1st degree > 2.5, 2nd degree 3.0-4.0, 3rd degree > 4.0 m/s. AS was detected in 16 patients (1.9%). AS severity was 1st, 2nd and 3rd degree in 9, 4 and 3 patients, respectively. Patients with AS were significantly older (77.4 vs. 61.3 years, p < 0.001), more often had history of chronic heart failure (CHF) (81.3 vs. 53.2%, p = 0.021) and lowered renal function (66.7 vs. 34.0%, p < 0.041). At multifactorial analysis independent prognostic value in relation to development of serious events showed age > 75 years (OR 1,395 [1.023-1.902], p = 0.036), history of CHF (1.319 [1.015-1.713], p = 0.038), history of MI (1.692 [1.320-2.170], p < 0.001), left ventricular diastolic dimention (1.023 [1.005-1.041], p = 0.012), left atrial diameter (1.024 [1.001-1.047], p = 0.037) and presence of AS (3.211 [1.742-.,916], p < 0.001). Prevalence of preexisting AS among patients who have had MI/UA is 1.9% what is similar to data of European Heart Survey ACS-II (1.8%). Presence of AS of any severity in a survivor of ACS worsens prognosis independently of other known risk factors.
authors.forename: O S
authors.initials: OS
authors.lastname: Chumakova
authors.forename: N D
authors.initials: ND
authors.lastname: Selezneva
authors.forename: M A
authors.initials: MA
authors.lastname: Evdokimova
authors.forename: B S
authors.initials: BS
authors.lastname: Osmolovskaia
authors.forename: M S
authors.initials: MS
authors.lastname: Kochkina
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Aseĭcheva
authors.forename: L O
authors.initials: LO
authors.lastname: Minushkina
authors.forename: T N
authors.initials: TN
authors.lastname: Baklanova
authors.forename: P A
authors.initials: PA
authors.lastname: Talyzin
authors.forename: S N
authors.initials: SN
authors.lastname: Tereshchenko
authors.forename: N A
authors.initials: NA
authors.lastname: Dzhaiani
authors.forename: E V
authors.initials: EV
authors.lastname: Akatova
authors.forename: M G
authors.initials: MG
authors.lastname: Glezer
authors.forename: A S
authors.initials: AS
authors.lastname: Galiavich
authors.forename: V B
authors.initials: VB
authors.lastname: Zakirova
authors.forename: N A
authors.initials: NA
authors.lastname: Koziolova
authors.forename: E A
authors.initials: EA
authors.lastname: Polianskaia
authors.forename: A V
authors.initials: AV
authors.lastname: Iagoda
authors.forename: O I
authors.initials: OI
authors.lastname: Boeva
authors.forename: E V
authors.initials: EV
authors.lastname: Khorolets
authors.forename: S V
authors.initials: SV
authors.lastname: Shlyk
authors.forename: E G
authors.initials: EG
authors.lastname: Volkova
authors.forename: O A
authors.initials: OA
authors.lastname: Rodicheva
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Levashov
authors.forename: V O
authors.initials: VO
authors.lastname: Konstantinov
authors.forename: N B
authors.initials: NB
authors.lastname: Kalishevich
authors.forename: D A
authors.initials: DA
authors.lastname: Zateĭshchikov
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D000367:Age Factors; D000368:Aged; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000150:complications / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D012720:Severity of Illness Index; D017741:Survivors / Q000706:statistics & numerical data; D014463:Ultrasonography