title: Role of the non-receptor tyrosine kinase fes in cancer.
abstract: Non receptor protein tyrosine kinases are targets in the treatment of a number of diseases. This review focuses on the role of Fes tyrosine kinase and on the design of inhibitors of this protein. Fes and its homologously related protein Fer are the only two members of a distinct class of non receptor tyrosine kinases and they seem to play a role in cytoskeletal rearrangements and inside-out signaling associated with receptor-ligand, cell-matrix and cell-cell interactions. The knowledge of the three dimensional structure of this protein, in fact, has informed drug design, while at the same time it has helped to shed some light on the molecular mechanism at the basis of kinase activation and functions.
authors.affiliation: DiSCAFF & DFB Center, University of Piemonte Orientale A. Avogadro, Novara, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Condorelli
authors.forename: E
authors.initials: E
authors.lastname: Stec-Martyna
authors.forename: J
authors.initials: J
authors.lastname: Zaborowska
authors.forename: L
authors.initials: L
authors.lastname: Felli
authors.forename: I
authors.initials: I
authors.lastname: Gnemmi
authors.forename: M
authors.initials: M
authors.lastname: Ponassi
authors.forename: C
authors.initials: C
authors.lastname: Rosano
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D051578:Proto-Oncogene Proteins c-fes / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D051578:Proto-Oncogene Proteins c-fes