title: A concise synthesis and antimicrobial activities of 3-polyamino-23,24-bisnorcholanes as steroid-polyamine conjugates.
abstract: A series of steroid-polyamine conjugates were synthesized and evaluated for their antimicrobial activity. This study was focused on the effect of stereochemistry at the C-3 and C-5 of steroids and types of polyamine at C-3 on activity against various human pathogens. All the conjugates exhibited strong antimicrobial activities against Gram-positive strains. Compound 18 was found to be the most potent in these series with a MIC value as low as 1 μg/mL against the bacterium Staphylococcus aureus ATCC6538P.
authors.affiliation: Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, Republic of Korea. kimhs@knu.ac.kr
authors.forename: Hong-Seok
authors.initials: HS
authors.lastname: Kim
authors.forename: Sharaf N
authors.initials: SN
authors.lastname: Khan
authors.forename: Jyoti R
authors.initials: JR
authors.lastname: Jadhav
authors.forename: Ji-Woong
authors.initials: JW
authors.lastname: Jeong
authors.forename: Kyungjin
authors.initials: K
authors.lastname: Jung
authors.forename: Jin-Hwan
authors.initials: JH
authors.lastname: Kwak
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002757:Cholanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D002757:Cholanes; D011073:Polyamines