title: Pandemic response lessons from influenza H1N1 2009 in Asia.
abstract: During April 2009, a novel H1N1 influenza A virus strain was identified in Mexico and the USA. Within weeks the virus had spread globally and the first pandemic of the 21st Century had been declared. It is unlikely to be the last and it is crucial that real lessons are learned from the experience. Asia is considered a hot spot for the emergence of new pathogens including past influenza pandemics. On this occasion while preparing for an avian, highly virulent influenza virus (H5N1 like) originating in Asia in fact the pandemic originated from swine, and was less virulent. This discrepancy between what was planned for and what emerged created its own challenges. The H1N1 pandemic has tested national health-care infrastructures and exposed shortcomings in our preparedness as a region. Key health challenges include communication throughout the region, surge capacity, access to reliable information and access to quality care, health-care worker skills, quality, density and distribution, access to essential medicines and lack of organizational infrastructure for emergency response. Despite years of preparation the public health and clinical research community were not ready to respond and opportunities for an immediate research response were missed. Despite warm words and pledges efforts to engage the international community to ensure equitable sharing of limited resources such as antivirals and vaccines fell short and stockpiles in the main remained in the rich world. This manuscript with authors from across the region describes some of the major challenges faced by Asia in response to the pandemic and draws lessons for the future.
authors.affiliation: Division of Infectious Diseases, National University Hospital, Singapore. dale_andrew_fisher@nuhs.edu.sg
authors.forename: Dale
authors.initials: D
authors.lastname: Fisher
authors.forename: David S
authors.initials: DS
authors.lastname: Hui
authors.forename: Zhancheng
authors.initials: Z
authors.lastname: Gao
authors.forename: Christopher
authors.initials: C
authors.lastname: Lee
authors.forename: Myoung-Don
authors.initials: MD
authors.lastname: Oh
authors.forename: Bin
authors.initials: B
authors.lastname: Cao
authors.forename: Tran Tinh
authors.initials: TT
authors.lastname: Hien
authors.forename: Krista
authors.initials: K
authors.lastname: Patlovich
authors.forename: Jeremy
authors.initials: J
authors.lastname: Farrar
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001208:Asia / Q000453:epidemiology; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects / Q000302:isolation & purification*; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology*; D009313:National Health Programs / Q000458:organization & administration / Q000706:statistics & numerical data; D058873:Pandemics; D011247:Pregnancy; D055872:Surge Capacity / Q000458:organization & administration
chemical_list: D000998:Antiviral Agents