title: Total synthesis and absolute stereochemical assignment of kibdelone C.
abstract: Kibdelones are hexacyclic tetrahydroxanthones and potent anticancer agents isolated from an Australian microbe. Herein, we describe the synthesis of a chiral, nonracemic iodocyclohexene carboxylate EF ring fragment of the kibdelones employing an intramolecular iodo halo-Michael aldol reaction and its merger with an ABCD ring fragment to afford the congener kibdelone C.
authors.affiliation: Center for Chemical Methodology and Library Development (CMLD-BU), Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Sloman
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Bacon
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D044004:Xanthones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D044004:Xanthones; C574351:kibdelone C