title: Genetic variations in FOXO3A are associated with Bipolar Disorder without confering vulnerability for suicidal behavior.
abstract: BACKGROUND
  Genetic variation plays an important role in Bipolar Disorder (BD) and suicide susceptibility. However, little is known about the genetic influence on the risk of suicide, particularly in BD patients. Since FOXO3A plays a role in distinct mood-relevant behavioral processes, this gene could be a novel gene candidate for BD. Thus, we investigated whether FOXO3A polymorphisms are associated with BD and suicidal behavior in BD patients.
  
  
  METHODS
  TaqMan genotyping was used to detect FOXO3A SNPs in 273 BD patients and 264 control subjects.
  
  
  RESULTS
  Three SNPs (rs1536057, rs2802292 and rs1935952) were associated with BD, but none was positively linked with suicidal behavior.
  
  
  CONCLUSIONS
  A systematic evaluation within the whole FOXO3A gene and drug treatment in patients was not performed.
  
  
  CONCLUSIONS
  These data suggest that FOXO3A is a novel susceptibility locus for BD, but not for suicidal behavior in BD patients. These results may contribute to a better understanding of the BD genetics.
authors.affiliation: Laboratório de Neurociência, INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil.
authors.forename: Luiz Alexandre V
authors.initials: LA
authors.lastname: Magno
authors.forename: Cinthia V N
authors.initials: CV
authors.lastname: Santana
authors.forename: Erika K
authors.initials: EK
authors.lastname: Sacramento
authors.forename: Vitor B
authors.initials: VB
authors.lastname: Rezende
authors.forename: Marcus V
authors.initials: MV
authors.lastname: Cardoso
authors.forename: Luiz
authors.initials: L
authors.lastname: Maurício-da-Silva
authors.forename: Fernando S
authors.initials: FS
authors.lastname: Neves
authors.forename: Débora M
authors.initials: DM
authors.lastname: Miranda
authors.forename: Luiz A
authors.initials: LA
authors.lastname: De Marco
authors.forename: Humberto
authors.initials: H
authors.lastname: Correa
authors.forename: Marco A
authors.initials: MA
authors.lastname: Romano-Silva
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology*; D004198:Disease Susceptibility; D005260:Female; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D059020:Suicidal Ideation; D013405:Suicide / Q000523:psychology*
chemical_list: C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors