title: Successful allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia during respiratory failure and invasive mechanical ventilation.
abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option for various hematologic disorders. However, life-threatening adverse events resulting from treatment-related toxicity, severe infections, and/or graft-versus-host disease (GvHD) can occur. We report on a 64-year-old patient suffering from secondary acute myeloid leukemia (AML) who underwent successful allogeneic HSCT while on invasive mandatory ventilation (IMV). The patient received reduced intensity conditioning (RIC) according to the FLAMSA-protocol. Acute respiratory failure occurred one day before scheduled HSCT. Following emergency endotracheal intubation the patient was transferred to the intensive care unit (ICU). Because of respiratory deterioration, stem cell infusion was postponed. After stabilization of respiratory parameters, HSCT was performed during IMV which was continued for seven days. Following hematopoietic regeneration the patient was discharged in good condition on day 35 after HSCT. This case illustrates that intubation and mechanical ventilation do not necessarily exclude leukemic patients from HSCT.
authors.affiliation: Department of Internal Medicine I, Bone Marrow Transplantation Unit, Medical University of Vienna, Vienna, Austria.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Boehm
authors.forename: Werner
authors.initials: W
authors.lastname: Rabitsch
authors.forename: Gottfried J
authors.initials: GJ
authors.lastname: Locker
authors.forename: Nina
authors.initials: N
authors.lastname: Worel
authors.forename: Oliver
authors.initials: O
authors.lastname: Robak
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Laczika
authors.forename: Thomas
authors.initials: T
authors.lastname: Staudinger
authors.forename: Andja
authors.initials: A
authors.lastname: Bojic
authors.forename: Viktoria
authors.initials: V
authors.lastname: Siersch
authors.forename: Peter
authors.initials: P
authors.lastname: Valent
authors.forename: Wolfgang R
authors.initials: WR
authors.lastname: Sperr
mesh_terms: D001853:Bone Marrow; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008175:Lung Neoplasms / Q000628:therapy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000628:therapy; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000628:therapy*; D019172:Transplantation Conditioning