title: Milestones in atypical and secondary Parkinsonisms.
abstract: During the last decades, atypical parkinsonian disorders such as multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy, and corticobasal degeneration along with secondary parkinsonian disorders have been increasingly recognized as important causes of parkinsonism. Although treatment options are largely limited to date, remarkable progress has occurred through advances in the fields of molecular biology and diagnostic neuroimaging, resulting in intense preclinical drug discovery programs. Early-investigation-assisted clinical diagnosis has become more crucial than ever because disease-modifying therapies will hopefully become available within this decade.
authors.affiliation: Division of Clinical Neurobiology, Department of Neurology, Medical University, Innsbruck, Austria. gregor.wenning@i-med.ac.at
authors.forename: Gregor K
authors.initials: GK
authors.lastname: Wenning
authors.forename: Irene
authors.initials: I
authors.lastname: Litvan
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tolosa
mesh_terms: D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D019578:Multiple System Atrophy / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D010302:Parkinson Disease, Secondary / Q000175:diagnosis* / Q000453:epidemiology / Q000266:history* / Q000503:physiopathology*; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics