title: Vaccine design of hemagglutinin glycoprotein against influenza.
abstract: Influenza viruses continue to cause annual epidemics and pose the threat of a deadly global pandemic. Vaccination has remained the best approach for prevention and control of influenza infection. However, current influenza vaccines are only effective against closely-matched circulating strains, and therefore must be updated and administered every year. In this review, we discuss recent developments in the search for better influenza vaccines, especially using the major virus surface glycoprotein hemagglutinins (HAs). Understanding how glycans on HAs affect the immune response and knowledge of how broadly neutralizing antibodies are induced will pave the way for a cross-protective influenza vaccine that does not require frequent updates or annual immunizations.
authors.affiliation: Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Taipei 115, Taiwan.
authors.forename: Juine-Ruey
authors.initials: JR
authors.lastname: Chen
authors.forename: Che
authors.initials: C
authors.lastname: Ma
authors.forename: Chi-Huey
authors.initials: CH
authors.lastname: Wong
mesh_terms: D000818:Animals; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology*; D006801:Humans; D007252:Influenza Vaccines / Q000138:chemical synthesis / Q000737:chemistry*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D011994:Recombinant Proteins / Q000737:chemistry / Q000276:immunology
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines; D011994:Recombinant Proteins