title: Urotensin-II 143 G/A polymorphism is not associated with the risk of preeclampsia in Korean women.
abstract: OBJECTIVE
  Urotensin-II (UTS-II) may be associated with preeclampsia. We therefore assessed whether the UTS-II 143 G/A polymorphism is associated with preeclampsia in Korean women.
  
  
  METHODS
  This prospective case-control study enrolled 109 patients with preeclampsia and 144 healthy pregnant controls, all of whom were genotyped for the UTS-II 143 G/A polymorphism using the real-time TaqMan SNP Genotyping Assay.
  
  
  RESULTS
  There was no significant difference in the distribution of the 143 G/A polymorphism or the frequency of the 143 A allele between women with preeclampsia and controls. In a dominant model, carriers of the A allele were not significantly more prevalent in the preeclamptic (53.2%) than in the control (60.4%) group. In addition, subgroup analysis showed no significant difference in genotype distribution or allelic frequency of the 143 G/A polymorphism between women with mild or severe preeclampsia and controls.
  
  
  CONCLUSIONS
  In Korean women, the common UTS-II 143 G/A polymorphism is unlikely to have an association with the risk of preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Kangwon National University College of Medicine, Chunchon, Korea.
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Na
authors.forename: Jae-Yoon
authors.initials: JY
authors.lastname: Shim
authors.forename: Bok-Kyung
authors.initials: BK
authors.lastname: Jung
authors.forename: Hye-Sung
authors.initials: HS
authors.lastname: Won
authors.forename: Pil Ryang
authors.initials: PR
authors.lastname: Lee
authors.forename: Ahm
authors.initials: A
authors.lastname: Kim
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics; D011446:Prospective Studies; D056910:Republic of Korea; D014579:Urotensins / Q000235:genetics*
chemical_list: D014579:Urotensins; C029677:urotensin II