title: Glaucoma progression after the first-detected optic disc hemorrhage by optical coherence tomography.
abstract: OBJECTIVE
  To evaluate the progression of glaucoma after first detected disc hemorrhage (DH) by time-domain optical coherence tomography (OCT).
  
  
  METHODS
  Forty-four eyes with a unilateral DH were allocated to the DH group and 44 fellow eyes to the non-DH group. OCT signal decrease indicating retinal nerve fiber layer thinning was defined as a decrease beyond the upper 95% limit of test-retest variability defined at the 95% confidence level of 44 control patients. The DH and non-DH groups were compared in terms of OCT-derived glaucoma progressions after the first detected DH. In addition, clock-hour locations of the OCT-derived progression were compared with those of DHs.
  
  
  RESULTS
  After a median 38.8±10.8 months of follow-up, 72.7% (32 of 44) of eyes in the DH group showed OCT-determined progression on a clock-hour basis, compared with 27.3% (12 of 44) of the fellow eyes in the non-DH group (P<0.0001, Fisher exact test). Eyes in the DH group showed more rapid and greater falls in clock-hour-based progression than fellow eyes in the non-DH group (P<0.0001, log-rank test). Twenty-nine eyes (90.6%) showed progression within 1 clock hour of the location of DH. However, no significant intergroup differences were observed in terms of OCT-determined progression on quadrant or average basis (P>0.05, respectively, Fisher exact test).
  
  
  CONCLUSIONS
  Rapid, spatially compatible, localized thinning of the retinal nerve fiber layer after the first detected DH was shown by Stratus OCT.
authors.affiliation: Department of Ophthalmology, Haeundae Paik Hospital, Korea.
authors.forename: Min Hee
authors.initials: MH
authors.lastname: Suh
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
authors.forename: Hyunjoong
authors.initials: H
authors.lastname: Kim
authors.forename: Tae-Woo
authors.initials: TW
authors.lastname: Kim
authors.forename: Seok Whan
authors.initials: SW
authors.lastname: Kim
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Dong Myung
authors.initials: DM
authors.lastname: Kim
mesh_terms: D001369:Axons / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis; D012165:Retinal Ganglion Cells / Q000473:pathology; D012166:Retinal Hemorrhage / Q000175:diagnosis*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular