title: [Effect of tinzaparin on survival in non-small-cell lung cancer after surgery. TILT: tinzaparin in lung tumours].
abstract: BACKGROUND
  Experimental and clinical findings suggest that low molecular-weight heparins may improve overall survival in patients with cancer. The evidence is still limited and additional studies are needed to confirm these preliminary findings.
  
  
  METHODS
  Patients with completely resected stage I, II or IIIA (T3N1) histologically confirmed non-small-cell lung cancer will be included in a prospective, controlled, randomized, multicenter open trial. Patients in the control group will receive usual postoperative care including chemotherapy when indicated. Patients in the experimental group will receive tinzaparin given subcutaneously as a daily 100 IU/kg dose for 90 days along with usual postoperative care. Patients will be followed-up for three to eight years. Main end-point is the overall survival. Five hundred and fifty patients are needed to demonstrate a 10% absolute increase in survival in the experimental group.
  
  
  RESULTS
  A 10% absolute increase in the survival rate is expected in the patients receiving tinzaparin.
authors.affiliation: Hôpital Européen Georges-Pompidou, 75908 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Meyer
authors.forename: B
authors.initials: B
authors.lastname: Besse
authors.forename: S
authors.initials: S
authors.lastname: Friard
authors.forename: P
authors.initials: P
authors.lastname: Girard
authors.forename: P
authors.initials: P
authors.lastname: Corbi
authors.forename: R
authors.initials: R
authors.lastname: Azarian
authors.forename: I
authors.initials: I
authors.lastname: Monnet
authors.forename: M
authors.initials: M
authors.lastname: Alifano
authors.forename: C
authors.initials: C
authors.lastname: Chouaid
authors.forename: R
authors.initials: R
authors.lastname: Descourt
authors.forename: G
authors.initials: G
authors.lastname: Dennewald
authors.forename: L
authors.initials: L
authors.lastname: Taillade
authors.forename: K
authors.initials: K
authors.lastname: De Luca
authors.forename: F
authors.initials: F
authors.lastname: Giraud
authors.forename: E
authors.initials: E
authors.lastname: Pichon
authors.forename: G
authors.initials: G
authors.lastname: Chatellier
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000601:surgery*; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000139:chemically induced; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007258:Informed Consent; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery*; D018579:Patient Selection; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D016019:Survival Analysis; D000078222:Tinzaparin; D020246:Venous Thrombosis / Q000517:prevention & control*
chemical_list: D006495:Heparin, Low-Molecular-Weight; D000078222:Tinzaparin