title: Intracellular uptake of (-)epicatechin by human erythrocytes as a function of human age.
abstract: The present studies were carried out to determine the intracellular uptake of (-)epicatechin by erythrocytes during aging in humans. (-)Epicatechin uptake was estimated by performing ethyl acetate extraction while the total antioxidant potential of the (-)epicatechin was estimated in terms of FRAP (ferric reducing ability of plasma) values. A significant (p < 0.001) decrease in (-)epicatechin uptake by human erythrocytes was observed as a function of age. It is hypothesized that the uptake of (-)epicatechin in human erythrocytes has an important role in the regulation of PMRS (plasma membrane redox system) activity during normal human aging.
authors.affiliation: Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida 201303, U.P. India. pawan_biochem@yahoo.co.in
authors.forename: Pawan Kumar
authors.initials: PK
authors.lastname: Maurya
authors.forename: Siya
authors.initials: S
authors.lastname: Prakash
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism; D028241:Camellia sinensis / Q000737:chemistry; D002392:Catechin / Q000097:blood* / Q000493:pharmacokinetics*; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D013662:Tea
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D013662:Tea; D002392:Catechin