title: The case of BK virus infection in which it was difficult to differentiate from acute rejection.
abstract: BK virus (BKV) nephropathy is one of the major causes of allograft dysfunction or graft loss in kidney transplant recipients. Early diagnosis and timely reduction in immunosuppressant is important for proper treatment. We report a 35-yr-old male case of cadaveric renal transplantation with BK viral related tubulointerstitial nephritis complicated by acute rejection. The diagnostic biopsy showed severe inflammatory infiltrates, tubulitis, and peritubular capillaritis. Discontinuation of mycophenolate mofetil, prednisone pulse therapy, and r-globulin was successful in relieving allograft dysfunction.
authors.affiliation: Division of Clinical Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan. yumiboston@yahoo.co.jp
authors.forename: Yumi
authors.initials: Y
authors.lastname: Ito
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nishi
authors.forename: Naofumi
authors.initials: N
authors.lastname: Imai
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshita
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Saito
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Kota
authors.initials: K
authors.lastname: Takahashi
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
mesh_terms: D000328:Adult; D001739:BK Virus / Q000472:pathogenicity*; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D003937:Diagnosis, Differential; D006084:Graft Rejection / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000628:therapy; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000209:etiology*; D027601:Polyomavirus Infections / Q000175:diagnosis / Q000209:etiology*; D014019:Tissue Donors; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000209:etiology*
chemical_list: D007166:Immunosuppressive Agents; D003404:Creatinine