title: Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression.
abstract: Linezolid, an oxazolidinone class derivative is a reversible and nonselective inhibitor of monoamine oxidase (MAO), predominantly for MAO-A type. MAO-A is a key enzyme regulating the catabolism of catecholamine neurotransmitters in the brain. It is well known that the catecholaminergic neuronal systems are associated with depression and inhibition of MAO-A level in the brain could be used to treat depression. Hence, the objective of this study was to evaluate the anti-depressant-like effect of linezolid, a MAO-A inhibitor in the animal models of depression. In the present study, linezolid (10 & 20mg/kg, i.p.), exhibited anti-depressant-like effects in forced swim test (FST) and tail suspension test (TST) in mice without influencing the baseline locomotion. Moreover, linezolid (10 & 20mg/kg, i.p.), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and antagonized the reserpine-induced hypothermia in rats. In conclusion, the behavioral investigation revealed the anti-depressant-like effect of linezolid in rodent's behavioral model.
authors.affiliation: Department of Pharmacy, Birla Institute of Technology & Science, Pilani-333031, Rajasthan, India.
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Mahesh
authors.forename: Ankur
authors.initials: A
authors.lastname: Jindal
authors.forename: Baldev
authors.initials: B
authors.lastname: Gautam
authors.forename: Shvetank
authors.initials: S
authors.lastname: Bhatt
authors.forename: Dilip
authors.initials: D
authors.lastname: Pandey
mesh_terms: D006916:5-Hydroxytryptophan / Q000627:therapeutic use; D000081:Acetamides / Q000627:therapeutic use*; D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001519:Behavior / Q000187:drug effects; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007035:Hypothermia / Q000139:chemically induced; D000069349:Linezolid; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D009043:Motor Activity / Q000187:drug effects; D023303:Oxazolidinones / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D023303:Oxazolidinones; D012110:Reserpine; D006916:5-Hydroxytryptophan; D000069349:Linezolid