title: Exome sequencing in Parkinson's disease.
abstract: Exome sequencing is rapidly becoming a fundamental tool for genetics and functional genomics laboratories. This methodology has enabled the discovery of novel pathogenic mutations causing mendelian diseases that had, until now, remained elusive. In this review, we discuss not only how we envisage exome sequencing being applied to a complex disease, such as Parkinson's disease, but also what are the known caveats of this approach.
authors.affiliation: Department of Molecular Neuroscience, Institute of Neurology, University College of London, London, UK. j.bras@ion.ucl.ac.uk
authors.forename: Jose M
authors.initials: JM
authors.lastname: Bras
authors.forename: A B
authors.initials: AB
authors.lastname: Singleton
mesh_terms: D000818:Animals; D005091:Exons / Q000235:genetics*; D016678:Genome / Q000235:genetics*; D006801:Humans; D009154:Mutation; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*; D017422:Sequence Analysis, DNA