title: Rare presentation of juvenile xanthogranuloma in the thoracic spine of an adult patient: case report and literature review.
abstract: Isolated spinal involvement of juvenile xanthogranuloma (JXG) is extremely rare. There are only seven prior published cases of spinal JXG, of which only one has been reported in an adult. We report here the eighth case of spinal JXG and the second in an adult. The patient, a 22-year-old female, presented with progressive upper backache. Radiological examination revealed a well-defined osteolytic hypointense mass in the T7 vertebral body, with a large soft tissue paraspinal extension causing cord compression. Complete resection of the mass was performed, with resolution of symptoms. Histology showed a histiocytic tumour with numerous Touton, foreign body and osteoclastic giant cells, immunopositive for CD68 and vimentin and negative for S100 and CD1a, corresponding to a diagnosis of JXG. Literature regarding spinal JXG is reviewed and discussed.
authors.affiliation: Department of Pathology, Sawai Man Singh Medical College, JLN Marg, Jaipur, Rajasthan, India. ayujain@rediffmail.com
authors.forename: Ayushi
authors.initials: A
authors.lastname: Jain
authors.forename: Kusum
authors.initials: K
authors.lastname: Mathur
authors.forename: Suman
authors.initials: S
authors.lastname: Khatri
authors.forename: Shweta
authors.initials: S
authors.lastname: Kasana
authors.forename: S K
authors.initials: SK
authors.lastname: Jain
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001416:Back Pain / Q000209:etiology; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D019635:Neurosurgical Procedures / Q000379:methods; D011859:Radiography; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome; D014972:Xanthogranuloma, Juvenile / Q000175:diagnosis* / Q000601:surgery*; D055815:Young Adult; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; C067980:CD68 antigen, human; D000097382:CD68 Molecule