title: Distress screening in allogeneic hematopoietic stem cell (HSCT) caregivers and patients.
abstract: Family caregivers of allogeneic hematopoietic stem cell transplant (HSCT) patients are at risk for experiencing significant psychological distress yet screening caregivers has not been well studied.
  
  
  OBJECTIVE
  This analysis explored the psychometric characteristics of the Distress Thermometer (DT) by examining its relationship, sensitivity, and specificity relative to the Brief Symptom Inventory 18 (BSI-18) and the Multidimensional Fatigue Symptom Inventory (MFSI) in a sample of allogeneic HSCT caregivers and patients.
  
  
  METHODS
  Longitudinal data were drawn from an ongoing intervention study for HSCT caregivers and patients. Data from one hundred and fifty-six English-speaking adults where patients (n = 65) were receiving their first allogeneic HSCT with at least one adult caregiver (n = 91) were eligible for this analysis. Study questionnaires were administered at baseline, initial discharge, and 6 weeks following discharge.
  
  
  RESULTS
  Construct validity was supported by significant relationships (p<0.001) between the DT and the BSI-18 GSI and the MFSI-Emotional subscales for caregivers and patients. The diagnostic utility of the DT for patients was good (AUC = 0.85±0.05, p = 0.001), while for caregivers it was poor (AUC = 0.61±0.08, p = 0.28). A DT cut point of 5 was supported for patients (sensitivity = 1.0, specificity = 0.68), while for caregivers there was less confidence (sensitivity = 0.70, specificity = 0.52). Caregivers and patients reporting a higher number of problems had a greater level of distress (p<0.001).
  
  
  CONCLUSIONS
  These findings support the validity of the DT in screening for distress in HSCT caregivers and patients. Although the diagnostic utility of the DT for HSCT caregivers may be limited, understanding factors associated with distress can guide practice for this understudied population.
authors.affiliation: National Institutes of Health, Clinical Center, Bethesda, MD, USA. mbevans@cc.nih.gov
authors.forename: Margaret
authors.initials: M
authors.lastname: Bevans
authors.forename: Leslie
authors.initials: L
authors.lastname: Wehrlen
authors.forename: Olena
authors.initials: O
authors.lastname: Prachenko
authors.forename: Karen
authors.initials: K
authors.lastname: Soeken
authors.forename: James
authors.initials: J
authors.lastname: Zabora
authors.forename: Gwenyth R
authors.initials: GR
authors.lastname: Wallen
mesh_terms: D000275:Adjustment Disorders / Q000175:diagnosis* / Q000523:psychology; D000328:Adult; D000368:Aged; D017028:Caregivers / Q000193:education / Q000523:psychology*; D017281:Cost of Illness; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D005221:Fatigue / Q000523:psychology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000523:psychology*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010147:Pain Measurement; D011340:Problem Solving; D011594:Psychometrics / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires