title: Extraneural metastases in medulloblastoma.
abstract: Medulloblastoma is the most common childhood malignant tumor of central nervous system, but it may also occur in adults. It presents high invasive growth with spreading of tumor cells into the leptomeningeal space along the neuroaxis early in the course of the disease. Extraneural metastases are rare but frequently lethal, occurring only in 1 to 5% of patients, and are related, in the most of cases, to the presence of ventriculoperitoneal shunt. Here we characterize the clinical profile of five cases of medulloblastoma with systemic spreading of tumor cells, also comparing them to cases already described in the literature.
authors.affiliation: Neurology Department, Medicine School, University of São Paulo, São Paulo, SP, Brazil. valeria.muoio@gmail.com
authors.forename: Valéria Marques Figueira
authors.initials: VM
authors.lastname: Muoio
authors.forename: Sueli Oba
authors.initials: SO
authors.lastname: Shinjo
authors.forename: Hamilton
authors.initials: H
authors.lastname: Matushita
authors.forename: Sérgio
authors.initials: S
authors.lastname: Rosemberg
authors.forename: Manoel Jacobsen
authors.initials: MJ
authors.lastname: Teixeira
authors.forename: Suely Kazue Nagahashi
authors.initials: SK
authors.lastname: Marie
mesh_terms: D000008:Abdominal Neoplasms / Q000556:secondary; D000328:Adult; D019046:Bone Marrow Neoplasms / Q000556:secondary; D002528:Cerebellar Neoplasms / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008527:Medulloblastoma / Q000556:secondary*; D010386:Pelvic Neoplasms / Q000556:secondary