title: Design, synthesis, and diversification of 3,5-substituted enone library.
abstract: This paper describes the synthesis of a 300 member library of 3,5-substituted enones. The synthesis starts with 6 different bromoenones that are accessed from the corresponding 1,3 diones. These bromides are then diversified by Suzuki coupling with a variety of aromatic and vinyl boronic acids. Additionally a small series of triazoles was synthesized by a Sonogashira coupling reaction dipolar cycloaddition sequence. The library was analyzed by principal component analysis to examine its diversity.
authors.forename: Juhienah
authors.initials: J
authors.lastname: Khalaf
authors.forename: Maria E
authors.initials: ME
authors.lastname: Estrella-Jimenez
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Shashack
authors.forename: Sharangdhar S
authors.initials: SS
authors.lastname: Phatak
authors.forename: Shuxing
authors.initials: S
authors.lastname: Zhang
authors.forename: Scott R
authors.initials: SR
authors.lastname: Gilbertson
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003512:Cyclohexanones / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D003512:Cyclohexanones