title: Resolution of diabetes mellitus by ileal transposition compared with biliopancreatic diversion in a nonobese animal model of type 2 diabetes.
abstract: BACKGROUND
  It has been demonstrated that biliopancreatic diversion (BPD) and ileal transposition (IT) effectively induce weight loss and long-term control of type 2 diabetes in morbidly obese individuals. It is unknown whether the control of diabetes is better after IT or after BPD. The objective of this study was to investigate the effects of IT and BPD on the control of diabetes in an animal model.
  
  
  METHODS
  We performed IT and BPD on 10- to 12-week-old Goto-Kakizaki rats with a spontaneous nonobese model of type 2 diabetes, and we performed a series of detection. The rats were observed for 24 weeks after surgery.
  
  
  RESULTS
  Animals who underwent IT and BPD demonstrated improved glucose tolerance, insulin sensitivity and the secretion of glucagon-like peptide-1 compared with the sham-operated animals. Furthermore, IT resulted in a shorter duration of surgery and better postoperative recovery than BPD.
  
  
  CONCLUSIONS
  This study provides strong evidence for the crucial role of the hindgut in the resolution of diabetes after duodenum-jejunum bypass or IT. We confirmed that IT was associated with better postoperative recovery than BPD and had a similar control of diabetes as BPD in nonobese animals with type 2 diabetes.
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China.
authors.forename: Guang Yong
authors.initials: GY
authors.lastname: Zhang
authors.forename: Tian Tian
authors.initials: TT
authors.lastname: Wang
authors.forename: Zhi Qiang
authors.initials: ZQ
authors.lastname: Cheng
authors.forename: Jin Bo
authors.initials: JB
authors.lastname: Feng
authors.forename: San Yuau
authors.initials: SY
authors.lastname: Hu
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D015904:Biliopancreatic Diversion; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000601:surgery*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000601:surgery*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D007082:Ileum / Q000601:surgery*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D051381:Rats
chemical_list: D001786:Blood Glucose; D052216:Glucagon-Like Peptide 1