title: [The effect of cerebrolysin in dosage 50 ml on the volume of lesion in ischemic stroke].
abstract: The purpose of this randomized, double-blind, placebo-controlled study was to assess safety and efficacy of cerebrolysin used in dosage 50 ml in acute ischemic stroke. Forty-seven patients with ischemic stroke, aged 45-85 years, who were admitted to a clinical unit within the first 12 h after stroke onset were included in the study. A quantitative time-related MRI analysis of the dynamics of neurological deficit revealed the more rapid decrease of stroke volume to the 28th day in the group treated with cerebrolysin (45.4% versus 43.6% in the placebo-group (p < 0.05)). No side-effects of treatment with cerebrolysin was found. The results of this prospective, randomized, placebo-controlled study suggest the positive effect of cerebrolysin on the dynamics of volume lesion in patients with ischemic stroke.
authors.forename: N A
authors.initials: NA
authors.lastname: Shamalov
authors.forename: L V
authors.initials: LV
authors.lastname: Stakhovskaia
authors.forename: D V
authors.initials: DV
authors.lastname: Burenchev
authors.forename: I V
authors.initials: IV
authors.lastname: Kichuk
authors.forename: T V
authors.initials: TV
authors.lastname: Tvorogova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Botsina
authors.forename: A S
authors.initials: AS
authors.lastname: Smychkov
authors.forename: O B
authors.initials: OB
authors.lastname: Kerbikov
authors.forename: H
authors.initials: H
authors.lastname: Moessler
authors.forename: P
authors.initials: P
authors.lastname: Novak
authors.forename: V I
authors.initials: VI
authors.lastname: Skvortsova
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000596:Amino Acids / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D020521:Stroke / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000596:Amino Acids; D018696:Neuroprotective Agents; C006952:cerebrolysin