title: Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating 99mTc-labelled compounds in high effective specific activity.
abstract: A new approach for preparing (99m)Tc-labelled compounds in high effective specific activity was developed by utilizing a novel fluorous ligand capture (FLC) agent and a chemoselective filtration strategy. This paradigm eliminates the need to use HPLC to obtain technetium(I) based molecular imaging probes free from residual precursor.
authors.affiliation: Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
authors.forename: Justin W
authors.initials: JW
authors.lastname: Hicks
authors.forename: Laura E
authors.initials: LE
authors.lastname: Harrington
authors.forename: John F
authors.initials: JF
authors.lastname: Valliant
mesh_terms: D005591:Chemical Fractionation / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D008024:Ligands; D015609:Organotechnetium Compounds / Q000737:chemistry* / Q000302:isolation & purification*; D012996:Solutions; D013379:Substrate Specificity
chemical_list: D008024:Ligands; D015609:Organotechnetium Compounds; D012996:Solutions