title: Bilateral optic disk swelling plus.
abstract: A 64-year-old woman presented with bilateral optic neuropathy leading to a diagnosis of Sjögren syndrome. She improved with high-dose corticosteroids and oral azathioprine and was subsequently found to have asymptomatic bilateral iridocyclitis. Although central nervous system manifestations of Sjögren syndrome are documented in the literature, they are not widely recognized in clinical practice. Associated optic neuritis often mimics demyelinating disease such as multiple sclerosis. Treatment of CNS disease related to Sjögren syndrome is highly controversial. Uveitis is an uncommon finding associated with Sjögren syndrome.
authors.affiliation: University of Illinois Eye and Ear Infirmary, Chicago, Illinois 60612, USA.
authors.forename: Sing Your
authors.initials: SY
authors.lastname: Li
authors.forename: Molly E
authors.initials: ME
authors.lastname: Gilbert
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Chavis
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015863:Iridocyclitis / Q000175:diagnosis / Q000188:drug therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010211:Papilledema / Q000175:diagnosis* / Q000188:drug therapy; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D014792:Visual Acuity
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D001379:Azathioprine; D008775:Methylprednisolone