title: Flavonoid C- and O-glycosides from the Mongolian medicinal plant Dianthus versicolor Fisch.
abstract: Eighteen flavonoids were identified from an aqueous extract of the aerial parts of Dianthus versicolor, a plant used in traditional Mongolian medicine against liver diseases. The flavonoid C- and O-glycosides isoorientin-7-O-rutinoside, isoorientin-7-O-rhamnosyl-galactoside, isovitexin-7-O-rutinoside, isovitexin-7-O-rhamnosyl-galactoside, isoscoparin-7-O-rutinoside, isoscoparin-7-O-rhamnosyl-galactoside, isoscoparin-7-O-galactoside, and isoorientin-7-O-galactoside were isolated and structurally elucidated. Their structures were established on the basis of extensive spectroscopic techniques including LC-UV-DAD, LC-MS(n), LC-HRMS, 1D and 2D NMR spectroscopy, and by GC-MS analysis after hydrolysis. Flavonoids with such a high glycosylation pattern are rare within the genus Dianthus. Furthermore, isovitexin-7-O-glucoside (saponarin), isovitexin-2″-O-rhamnoside, apigenin-6-glucoside (isovitexin), luteolin-7-O-glucoside, apigenin-7-O-glucoside, as well as the aglycons luteolin, apigenin, chrysoeriol, diosmetin, and acacetin were identified by TLC and LC-DAD-MS(n) in comparison to reference substances or literature data. The NMR data of seven structures have not been reported in the literature to date.
authors.affiliation: Department of Pharmacognosy, University of Vienna, Vienna, Austria.
authors.forename: Astrid
authors.initials: A
authors.lastname: Obmann
authors.forename: Ingrid
authors.initials: I
authors.lastname: Werner
authors.forename: Armin
authors.initials: A
authors.lastname: Presser
authors.forename: Martin
authors.initials: M
authors.lastname: Zehl
authors.forename: Zita
authors.initials: Z
authors.lastname: Swoboda
authors.forename: Sodnomtseren
authors.initials: S
authors.lastname: Purevsuren
authors.forename: Samdan
authors.initials: S
authors.lastname: Narantuya
authors.forename: Christa
authors.initials: C
authors.lastname: Kletter
authors.forename: Sabine
authors.initials: S
authors.lastname: Glasl
mesh_terms: D002851:Chromatography, High Pressure Liquid; D029749:Dianthus / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006027:Glycosides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D006027:Glycosides