title: Biomarkers of radiosensitivity in a-bomb survivors pregnant at the time of bombings in hiroshima and nagasaki.
abstract: Purpose. There is evidence in the literature of increased maternal radiosensitivity during pregnancy. Materials and Methods. We tested this hypothesis using information from the atomic-bomb survivor cohort, that is, the Adult Health Study database at the Radiation Effects Research Foundation, which contains data from a cohort of women who were pregnant at the time of the bombings of Hiroshima and Nagasaki. Previous evaluation has demonstrated long-term radiation dose-response effects. Results/Conclusions. Data on approximately 250 women were available to assess dose-response rates for serum cholesterol, white blood cell count, erythrocyte sedimentation rate, and serum hemoglobin, and on approximately 85 women for stable chromosome aberrations, glycophorin A locus mutations, and naïve CD4 T-cell counts. Although there is no statistically significant evidence of increased radiosensitivity in pregnant women, the increased slope of the linear trend line in the third trimester with respect to stable chromosome aberrations is suggestive of an increased radiosensitivity.
authors.affiliation: Division of Radiation Oncology, Department of Radiology, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23314, USA.
authors.forename: Edward F
authors.initials: EF
authors.lastname: Miles
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Tatsukawa
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Funamoto
authors.forename: Naoko
authors.initials: N
authors.lastname: Kamada
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakashima
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kodama
authors.forename: Thomas
authors.initials: T
authors.lastname: Seed
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kusonoki
authors.forename: Kei
authors.initials: K
authors.lastname: Nakachi
authors.forename: Saeko
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Masazumi
authors.initials: M
authors.lastname: Akahoshi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Neriishi