title: The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status.
abstract: OBJECTIVE
  To explore associations between IRS-1 rs1801278 G>A polymorphism and metabolic syndrome (MS).
  
  
  METHODS
  rs1801278 G>A was genotyped in 610 healthy Argentinian men.
  
  
  RESULTS
  GA carriers had lower risk of MS (OR=0.52, P=0.045), particularly among smokers (OR=0.10, P=0.006).
  
  
  CONCLUSIONS
  rs1801278 GA carriers had lower risk of MS, especially among smokers.
authors.affiliation: Laboratory of Molecular Biology, Department of Genetics and Molecular Biology, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), Argentina.
authors.forename: María Silvia
authors.initials: MS
authors.lastname: Pérez
authors.forename: Mariana L
authors.initials: ML
authors.lastname: Tellechea
authors.forename: Florencia
authors.initials: F
authors.lastname: Aranguren
authors.forename: Mariano J
authors.initials: MJ
authors.lastname: Taverna
authors.forename: Ricardo G
authors.initials: RG
authors.lastname: Rodríguez
authors.forename: Tomás
authors.initials: T
authors.lastname: Meroño
authors.forename: Fernando
authors.initials: F
authors.lastname: Brites
authors.forename: Edgardo
authors.initials: E
authors.lastname: Poskus
authors.forename: Gustavo D
authors.initials: GD
authors.lastname: Frechtel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001118:Argentina / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D055815:Young Adult
chemical_list: C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins