title: The truth about genetic variation in the serotonin transporter gene and response to stress and medication.
abstract: The question of whether a functional variant in the promoter of the serotonin transporter gene (5-HTTLPR) influences response to adversity and/or antidepressants has generated great interest and controversy. A review of the literature suggests that the issue is complicated by differences in methodology and sample ethnicity. When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity.
authors.forename: Peter
authors.initials: P
authors.lastname: McGuffin
authors.forename: Shaza
authors.initials: S
authors.lastname: Alsabban
authors.forename: Rudolf
authors.initials: R
authors.lastname: Uher
mesh_terms: D000818:Animals; D015986:Confounding Factors, Epidemiologic; D003863:Depression / Q000188:drug therapy* / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D008253:Macaca mulatta; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013315:Stress, Psychological / Q000235:genetics
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; C493230:SLC6A4 protein, human