title: A nonpeptidic reverse-turn scaffold stabilized by urea-based dual intramolecular hydrogen bonding.
abstract: A novel nonpeptidic reverse-turn scaffold containing urea fragments that are connected by a conformationally constrained D-prolyl-cis-1,2-diaminocyclohexane (D-Pro-DACH) linker is reported. The scaffold adopts a well-defined reverse-turn conformation that is stabilized by dual intramolecular hydrogen bonding in both solution and solid states.
authors.affiliation: Molecular-Level Interface Research Center, Department of Chemistry, KAIST, Daejeon 305-701, Korea.
authors.forename: Amiya K
authors.initials: AK
authors.lastname: Medda
authors.forename: Chul Min
authors.initials: CM
authors.lastname: Park
authors.forename: Aram
authors.initials: A
authors.lastname: Jeon
authors.forename: Hyunwoo
authors.initials: H
authors.lastname: Kim
authors.forename: Jeong-Hun
authors.initials: JH
authors.lastname: Sohn
authors.forename: Hee-Seung
authors.initials: HS
authors.lastname: Lee
mesh_terms: D003514:Cyclohexylamines / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D014508:Urea / Q000737:chemistry*
chemical_list: D003514:Cyclohexylamines; D010455:Peptides; D014508:Urea; D011392:Proline