title: Incidence of cancer in kidney transplantation waiting list patients: a single center experience.
abstract: BACKGROUND
  It is widely accepted that the risk of malignancies is significantly increased among patients with end-stage kidney disease (ESKD) and after kidney transplantation compared with the general population. Only a few data are available on kidney transplantation waiting list patients. The aim of this study was to investigate solid organ cancer incidence among subjects on the waiting list at a single center.
  
  
  METHODS
  We retrospectively reviewed the records of all patients enrolled on our kidney transplantation waiting list between August 1, 2008 and July 31, 2010, seeking to evaluate the causes of withdrawal from the list, incidence of cancer, type of neoplasm, and its correlation with clinical features. We estimated the ratio of observed to expected numbers of cancers, the standardized incidence ratio (SIR).
  
  
  RESULTS
  Among 1184 patients, we excluded 569 patients from the waiting list including 26 (4.56%) who displayed malignancies. The overall incidence of cancer was 0.11 events/person-months and the overall prevalence of cancer was 2.2%. In 97% of patients, the malignant disease was confined to the primitive organ of origin without secondary dissemination. We observed a prevalence of cancers related to ESKD (17; 65.38%). The SIR for all cancer types in our population compared with the general population was 2.22. The SIR for native kidney and thyroid cancers among our population compared with the general population was >10.
  
  
  CONCLUSIONS
  The incidence of cancer was significantly increased among kidney transplantation waiting list patients compared with the general population. Our study highlighted the importance of a careful, targeted neoplastic screening. It could be particularly important for ESKD-related malignancies like native kidney tumors or thyroid cancers.
authors.affiliation: Section of Nephrology, Department of Internal Medicine, Aging and Renal Disease, St. Orsola Hospital, University of Bologna, Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Mosconi
authors.forename: L
authors.initials: L
authors.lastname: Stalteri
authors.forename: F
authors.initials: F
authors.lastname: Centofanti
authors.forename: I
authors.initials: I
authors.lastname: Capelli
authors.forename: E
authors.initials: E
authors.lastname: Carretta
authors.forename: E
authors.initials: E
authors.lastname: Persici
authors.forename: G
authors.initials: G
authors.lastname: Ubaldi
authors.forename: G
authors.initials: G
authors.lastname: Battaglino
authors.forename: C
authors.initials: C
authors.lastname: Raimondi
authors.forename: M P
authors.initials: MP
authors.lastname: Scolari
authors.forename: S
authors.initials: S
authors.lastname: Stefoni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000601:surgery; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D014850:Waiting Lists; D055815:Young Adult