title: [Association of C677T gene polymorphism of methylenetetrahydrofolate reductase with insulin resistance among Kirghizes].
abstract: OBJECTIVE
  To study an association of C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) and insulin resistance (IR) among ethical Kirghizes.
  
  
  METHODS
  132 Kirghiz patients with IR according to HOMA index (n=132) and sex and age matched patients without IR, diabetes mellitus (DM) type 2 or metabolic syndrome (MS) (n=132) were included into this study. Measurements of blood pressure (BP), body mass index, waist and hip circumference, fasting blood sugar, insulin, lipid parameters and C677T gene polymorphism of MTHFR were performed in all patients.
  
  
  RESULTS
  Frequency of CT and TT genotypes was significantly higher in patients with IR than in controls (2 - 7.22, p - 0,027, OR - 1.68, 95% confidence interval 1.13-2.5, p=0.027). T677 allele was also associated with obesity, hypertriglyceridemia and low level of high density lipoprotein cholesterol (HDL-C).
  
  
  CONCLUSIONS
  In Kirghizes carriage of T677 allele of MTHFR gene was associated with IR, abdominal obesity, hypertriglyceridemia and low HDL-C level.
authors.forename: O S
authors.initials: OS
authors.lastname: Lunegova
authors.forename: A S
authors.initials: AS
authors.lastname: Kerimkulova
authors.forename: N B
authors.initials: NB
authors.lastname: Turdakmatov
authors.forename: N A
authors.initials: NA
authors.lastname: Sovkhozova
authors.forename: M P
authors.initials: MP
authors.lastname: Nabiev
authors.forename: Zh T
authors.initials: ZhT
authors.lastname: Isakova
authors.forename: É U
authors.initials: ÉU
authors.lastname: Iusupova
authors.forename: Ch B
authors.initials: ChB
authors.lastname: Moldokeeva
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Gotfrid
authors.forename: A É
authors.initials: AÉ
authors.lastname: Mirrakhimov
authors.forename: N M
authors.initials: NM
authors.lastname: Aldasheva
authors.forename: E
authors.initials: E
authors.lastname: Kheĭer
authors.forename: A A
authors.initials: AA
authors.lastname: Aldashev
authors.forename: É M
authors.initials: ÉM
authors.lastname: Mirrakhimov
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D008076:Cholesterol, HDL / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D007707:Kyrgyzstan / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000453:epidemiology / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: D008076:Cholesterol, HDL; D042965:Methylenetetrahydrofolate Reductase (NADPH2)