title: Translating genomic research into care for people with schizophrenia in China.
abstract: The implications of increased understanding of the genetic contribution to schizophrenia for patients and their families remain unclear. We carried out a study of Chinese patients'(n=118) and relatives' (n=78) views of illness severity, attribution of cause, concern about developing illness, and effect of schizophrenia on family planning. A comparison sample of English-survey respondents was also obtained, using the same series of questions (n=42 patients, n=127 relatives). Fewer Chinese patients and family members rated schizophrenia as very severe (33%) than did the predominantly North American respondents (67%, p<0.0001). The pattern of attribution of cause differed between samples (p<0.0001), favoring environmental alone in the Chinese sample (52%), with a low frequency of genetics alone (9%). Although comparatively fewer Chinese respondents were very concerned about developing schizophrenia themselves or about the risk of illness in their families (21%), this high level of concern was more common in family members (28%). Finally, Chinese respondents were somewhat less likely to indicate that schizophrenia impacted on family planning decisions (31%) than were English-survey respondents (45%, p=0.02). The descriptive findings contribute to understanding schizophrenia in China. The comparative findings must be regarded as preliminary, since differences in demographics could influence results. The present findings suggest that understanding patients' and families' attributions of cause of schizophrenia may be important for developing a shared model of illness in order to decrease stigmatization, and improve therapeutic alliances.
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. rckchan@psych.ac.cn
authors.forename: Raymond C K
authors.initials: RC
authors.lastname: Chan
authors.forename: Jehannine C
authors.initials: JC
authors.lastname: Austin
authors.forename: Veronica J
authors.initials: VJ
authors.lastname: Pearson
authors.forename: Qi-yong
authors.initials: QY
authors.lastname: Gong
authors.forename: William G
authors.initials: WG
authors.lastname: Honer
mesh_terms: D000328:Adult; D000367:Age Factors; D017028:Caregivers / Q000523:psychology*; D002681:China; D003431:Cross-Cultural Comparison; D005190:Family / Q000523:psychology*; D005260:Female; D023281:Genomics; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D012938:Social Perception; D055815:Young Adult