title: Metastatic splenic α-fetoprotein-producing adenocarcinoma: report of a case.
abstract: Solitary carcinomatous metastases to the spleen are rare, and the presence of solitary splenic metastasis of hepatoid adenocarcinomas (HAC) has not yet been reported. We herein present the case of a 54-year-old male patient who developed a metastatic tumor to the spleen with enhanced levels of serum α-fetoprotein and carcinoembryonic antigen (CEA). The patient underwent a gastrectomy due to adenocarcinoma of the stomach 5 years previously. The tumor was diagnosed on the grounds of histopathology and immunohistochemical staining after splenectomy. The pathology slides showed both adenocarcinoma and hepatoid structures. α-Fetoprotein antibody staining was positive in the tumor, suggesting hepatoid characteristics. After the operation, the patient recovered well and had no signs of recurrence at a follow-up examination after 9 months. Together with this case, several aspects of the disease are discussed after a review of the current literature.
authors.affiliation: Department of Hepatobiliary Surgery, Xiamen University Zhongshan Hospital, 209 South Hubin Road, 361004, Xiamen, PR China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Deng
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Yin
authors.forename: Shouhui
authors.initials: S
authors.lastname: Chen
authors.forename: Youyuan
authors.initials: Y
authors.lastname: Peng
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Wang
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000378:metabolism* / Q000556:secondary; D002272:Carcinoembryonic Antigen / Q000097:blood; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000097:blood / Q000378:metabolism* / Q000556:secondary; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D002272:Carcinoembryonic Antigen; D000509:alpha-Fetoproteins