title: A platinum Chugaev carbene complex as a potent anticancer agent.
abstract: A platinum Chugaev complex was synthesised and fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. This cis bis acyclic diamino carbene complex acts as a cytotoxic compound and behaves as a cisplatin equivalent by interacting with supercoiled DNA and thiols. Stability of the ligand is also discussed.
authors.affiliation: CNRS, UMR 6247, GReD Laboratory, 24 Ave des Landais, F-63177, Aubière, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Alves
authors.forename: Laurent
authors.initials: L
authors.lastname: Morel
authors.forename: Malika
authors.initials: M
authors.lastname: El-Ghozzi
authors.forename: Daniel
authors.initials: D
authors.lastname: Avignant
authors.forename: Bertrand
authors.initials: B
authors.lastname: Legeret
authors.forename: Lionel
authors.initials: L
authors.lastname: Nauton
authors.forename: Federico
authors.initials: F
authors.lastname: Cisnetti
authors.forename: Arnaud
authors.initials: A
authors.lastname: Gautier
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004278:DNA, Superhelical / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004278:DNA, Superhelical; D009944:Organoplatinum Compounds; D013438:Sulfhydryl Compounds; C030011:carbene; D008697:Methane