title: The extra-hematopoietic role of erythropoietin in diabetes mellitus.
abstract: Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia and vascular complications, leading to significant morbidity and mortality. All forms of diabetes are ultimately related to insufficient functional pancreatic β-cell mass to maintain euglycemia. In this context, the promotion of β-cell survival and function is a fundamental issue of direct relevance to diabetes prevention and treatment. Although first identified as a hematopoietic factor that promotes erythropoiesis and erythrocyte survival, an accumulating body of evidence suggests that erythropoietin (EPO) may also exert cytoprotective effects on non-erythroid tissues, including the brain, kidney, blood vessels, and pancreatic β cells. Recent reports have demonstrated the biological effects of EPO on the pancreatic β cells and its potential preventative and therapeutic role in diabetes. This review will focus on the emerging extra-hematopoietic roles of EPO and its potential protective role in diabetes.
authors.affiliation: University of Toronto, Toronto, Ontario, M5G 2M9, Canada.
authors.forename: Diana
authors.initials: D
authors.lastname: Choi
authors.forename: Ravi
authors.initials: R
authors.lastname: Retnakaran
authors.forename: Minna
authors.initials: M
authors.lastname: Woo
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D048909:Diabetes Complications / Q000188:drug therapy; D003920:Diabetes Mellitus / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D004921:Erythropoietin / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D006413:Hematopoietic System / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008954:Models, Biological
chemical_list: D001786:Blood Glucose; D004921:Erythropoietin