title: Asymmetric synthesis of the core structure of leucosceptroids A-D.
abstract: The asymmetric synthesis of the core structure of leucosceptroids A-D has been achieved. The key steps of the synthesis includes the formation of the cis-2,5-disubstituted THF ring by TPAP catalytic oxidative cyclization followed by a highly diastereoselective intramolecular Diels-Alder reaction to fashion the fused tricyclic hydrindane ring system.
authors.affiliation: Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, California 91010, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Ma
authors.forename: David A
authors.initials: DA
authors.lastname: Horne
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D054830:Sesterterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006575:Heterocyclic Compounds, 3-Ring; D054830:Sesterterpenes; C552074:leucosceptroid A; C569088:leucosceptroid B; C569089:leucosceptroid C; C569090:leucosceptroid D