title: Hypocholesterolemic Effects of N-[(2-Hydroxy-3-N,N-Dimethylhexadecyl Ammonium)Propyl] Chitosan Chloride in High-Fat-Diet-Induced Rats.
abstract: In this paper, the potential hypocholesterolemic effect of N-[(2-hydroxy-3-N,N-dimethylhexadecyl ammonium)propyl] chitosan chloride (N-CQCs) was studied. In vivo hypocholesterolemic tests of N-CQCs were carried out to examine the effect on LDL, HDL, TC, leptin, FFA and SOD. The results showed that LDL, TC, leptin and FFA were decreased after supplementation with N-CQCs in the high-fat diet, preliminarily indicating that N-CQCs have a better hypocholesterolemic effect than chitosan. SOD was significantly elevated by N-CQCs compared with that of HF and HFC groups. N-CQCs increased antioxidant activity of SOD, indicating that N-CQCs regulated antioxidant enzyme activities and might reduced lipid peroxidation.
authors.affiliation: a Department of Polymer Materials Science and Engineering, College of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China; Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, P. R. China. liuxf@tju.edu.cn.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Liu
authors.forename: Anrong
authors.initials: A
authors.lastname: Zeng
authors.forename: Tao
authors.initials: T
authors.lastname: Song
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaona
authors.initials: X
authors.lastname: Zhi
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D048271:Chitosan / Q000031:analogs & derivatives* / Q000494:pharmacology; D059305:Diet, High-Fat / Q000009:adverse effects*; D005243:Feces / Q000737:chemistry; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D020738:Leptin; D008055:Lipids; C569571:N-((2-hydroxy-3-N,N-dimethylhexadecylammonium)propyl)chitosan chloride; D048271:Chitosan; D013482:Superoxide Dismutase