title: Decreased serum brain-derived neurotrophic factor concentration in young nonobese subjects with low insulin sensitivity.
abstract: OBJECTIVE
  Insulin resistance and type 2 diabetes are associated with an increased risk of neurodegenerative diseases. Decreased brain-derived neurotrophic factor (BDNF) levels might play a role in the pathogenesis of neuropsychiatric disorders. The aim of our study was to estimate serum BDNF concentration in nonobese women divided into subgroups according to their insulin sensitivity.
  
  
  METHODS
  We studied 46 young, healthy, nonobese women. Insulin sensitivity was estimated with the euglycemic-hyperinsulinemic clamp technique. Then, participants were divided into subgroups of high (mean, 12.79±2.01mg/kg fat-free mass/min) and low insulin sensitivity (mean, 7.33±1.66mg/kg fat-free mass/min).
  
  
  RESULTS
  We observed decreased serum BDNF concentration in women with low insulin sensitivity in comparison to high insulin sensitivity group (3306.11±603.10 vs 4141.91±755.37pg/mL, p=0.001). Serum BDNF was positively related to insulin sensitivity (r=0.43, p=0.003). This correlation remained significant after adjustment for other estimated parameters.
  
  
  CONCLUSIONS
  Serum BDNF is decreased in young nonobese women with low insulin sensitivity. Early detection and prevention of insulin resistance might be useful in the prevention of neurodegenerative disorders.
authors.affiliation: Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Poland. monika3101@wp.pl
authors.forename: Monika
authors.initials: M
authors.lastname: Karczewska-Kupczewska
authors.forename: Marek
authors.initials: M
authors.lastname: Strączkowski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Adamska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Nikołajuk
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Otziomek
authors.forename: Maria
authors.initials: M
authors.lastname: Górska
authors.forename: Irina
authors.initials: I
authors.lastname: Kowalska
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D009765:Obesity / Q000097:blood
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D007328:Insulin