title: Elevated triglycerides/HDL-cholesterol ratio associated with insulin resistance.
abstract: BACKGROUND
  Cardiovascular disease is the main cause of death worldwide and insulin resistance (IR) plays an important role for its development. In addition, IR has been associated with hypertension and metabolic syndrome according to the triglyceride/HDL-cholesterol (TGL/HDL) ratio. We undertook this study to determine whether the TGL/HDL ratio is associated with IR in apparently healthy subjects.
  
  
  METHODS
  A cross-sectional study including healthy men and nonpregnant women was performed. Individuals with IR were compared against subjects without IR. Variables studied were age, gender, body mass index, and waist circumference. Exclusion criteria were chronic diseases such as renal disease, hepatic disease, malignancy, and diabetes.
  
  
  RESULTS
  A total of 177 subjects were enrolled, 117 females (66.1%) and 60 males (33.9%). Of these, 145 (93 females and 52 males) with IR were compared against 32 subjects (24 females and 8 males) without IR. Elevated ratio TGL/HDL ratio was detected in 89 (61.4%) and 12 (38.6%) subjects with and without IR, respectively. The elevated TGL/HDL ratio was significantly associated with IR (OR 2.64, 95% CI = 1.12-6.29).
  
  
  CONCLUSIONS
  In apparently healthy subjects, elevated TGL/HDL ratio was significantly associated with the presence of IR.
authors.affiliation: Unidad 308, Servicio de Medicina Interna, Hospital General de México, Secretaría de Salud, México, D. F., Mexico. antglez51@yahoo.com.mx.
authors.forename: Antonio
authors.initials: A
authors.lastname: González-Chávez
authors.forename: Luis Ernesto
authors.initials: LE
authors.lastname: Simental-Mendía
authors.forename: Sandra
authors.initials: S
authors.lastname: Elizondo-Argueta
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D015897:Comorbidity; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000378:metabolism*; D015228:Hypertriglyceridemia / Q000453:epidemiology / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D012306:Risk; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol