title: Inherited mitochondrial variants are not a major cause of age-related hearing impairment in the European population.
abstract: Mitochondrial DNA (mtDNA) mutations have been implicated in various age-related diseases. To further clarify the role of mtDNA variants in age-related hearing impairment (ARHI), we determined the DNA sequence of the entire mitochondrial genome of 400 individuals using the Affymetrix Human Mitochondrial Resequencing Array. These were the 200 worst hearing and the 200 best hearing from a collection of 947 Belgian samples. We performed association tests with individual mitochondrial variants, comparison of the mutation load, and association with European haplogroups and their interaction with environmental risk factors. We also tested the influence of rare variants on ARHI. None of these tests showed any association with ARHI.
authors.affiliation: Department of Medical Genetics, University of Antwerp, Antwerp, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Bonneux
authors.forename: E
authors.initials: E
authors.lastname: Fransen
authors.forename: E
authors.initials: E
authors.lastname: Van Eyken
authors.forename: L
authors.initials: L
authors.lastname: Van Laer
authors.forename: J
authors.initials: J
authors.lastname: Huyghe
authors.forename: P
authors.initials: P
authors.lastname: Van de Heyning
authors.forename: A
authors.initials: A
authors.lastname: Voets
authors.forename: M
authors.initials: M
authors.lastname: Gerards
authors.forename: A P M
authors.initials: AP
authors.lastname: Stassen
authors.forename: A T M
authors.initials: AT
authors.lastname: Hendrickx
authors.forename: H J M
authors.initials: HJ
authors.lastname: Smeets
authors.forename: G
authors.initials: G
authors.lastname: Van Camp
mesh_terms: D000368:Aged; D001530:Belgium / Q000453:epidemiology; D050259:Genes, Mitochondrial; D056726:Genetic Association Studies; D006239:Haplotypes; D040941:Heredity; D006801:Humans; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics*; D009154:Mutation; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011304:Presbycusis / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D018709:Statistics, Nonparametric