title: Sesquarterpenes (C35 terpenes) biosynthesized via the cyclization of a linear C35 isoprenoid by a tetraprenyl-β-curcumene synthase and a tetraprenyl-β-curcumene cyclase: identification of a new terpene cyclase.
abstract: In this study, mono- and pentacyclic C(35) terpenes from Bacillus subtilis were biosynthesized via the cyclization of C(35) isoprenoid using purified enzymes, including the first identified new terpene cyclase that shows no sequence homology to any of the known terpene cyclases. On the basis of these findings, we propose that these C(35) terpenes should be called the new family of "sesquarterpenes."
authors.affiliation: Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, 8050 Ikarashi-2, Niigata 950-2181, Japan. satot@agr.niigata-u.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Satoru
authors.initials: S
authors.lastname: Yoshida
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hoshino
authors.forename: Mizuki
authors.initials: M
authors.lastname: Tanno
authors.forename: Mami
authors.initials: M
authors.lastname: Nakajima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hoshino
mesh_terms: D001412:Bacillus subtilis / Q000201:enzymology* / Q000378:metabolism; D003474:Curcumin / Q000031:analogs & derivatives; D003500:Cyclization; D004798:Enzymes / Q000378:metabolism*; D013729:Terpenes / Q000378:metabolism
chemical_list: D004798:Enzymes; D013729:Terpenes; D003474:Curcumin