title: Synthesis of P-triazinylphosphonium salts--hybrid molecules with potential antimicrobial activity.
abstract: The new hybrid drugs combining in a single molecule triazine ring attached to phosphonium salt were prepared and their bactericidal activity against Gram-positive bacteria Staphylococcus aureus ATCC43300 (MRSA - methycyline resistant Staphylococcus aureus strain) two Gram-negative bacteria Escherichia coli CCUG31997 serotype O153 (EPEC - enteropathogenic Escherichia coli strain), Proteus mirabilis 1784 (MDR - multidrug resistant clinical strain) were determined using microdilution method.
authors.affiliation: Institute of Organic Chemistry, Technical University of Łódź, Zeromskiego 116, 90-924 Łódź, Poland. beata.kolesinska@p.lodz.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Kolesińska
authors.forename: Rafał
authors.initials: R
authors.lastname: Motylski
authors.forename: Zbigniew J
authors.initials: ZJ
authors.lastname: Kamiński
authors.forename: Marek
authors.initials: M
authors.lastname: Kwinkowski
authors.forename: Wiesław
authors.initials: W
authors.lastname: Kaca
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D054308:Enteropathogenic Escherichia coli / Q000187:drug effects / Q000254:growth & development; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D011513:Proteus mirabilis / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D009943:Organophosphorus Compounds; D014227:Triazines