title: Anti-ribosomal P antibodies and lupus nephritis.
abstract: Increasing attention has been paid to the relationship of autoantibodies to ribosomal P proteins (anti-P) with lupus nephritis. Several mechanisms of involvement of anti-P in lupus nephritis have been proposed, including cross-reactivity with anti-dsDNA and anti-endothelial cell antibodies (AECA). In addition, it is also suggested that anti-P might play a role in the development of lupus nephritis through induction of T helper 1 responses. Of note, recent studies have disclosed that the presence of isolated anti-P antibodies may discriminate patients with pure class V lupus nephritis, whereas the simultaneous presence of anti-dsDNA antibodies suggests class V disease with concomitant proliferative lesions. These observations lead to the hypothesis that anti-P and anti-dsDNA might result in membraneous changes and proliferative changes, respectively, although further investigation is required for confirmation.
authors.affiliation: Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1-15-1 Kitasato, Minamiku, Sagamihara, Kanagawa 252-0374, Japan. shunsei_tenpoint@yahoo.co.jp
authors.forename: Shunsei
authors.initials: S
authors.lastname: Hirohata
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001323:Autoantibodies / Q000276:immunology* / Q000502:physiology; D003429:Cross Reactions; D004247:DNA / Q000276:immunology; D006801:Humans; D008181:Lupus Nephritis / Q000209:etiology / Q000276:immunology*; D051379:Mice; D010750:Phosphoproteins / Q000276:immunology; D012269:Ribosomal Proteins / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology
chemical_list: D001323:Autoantibodies; D010750:Phosphoproteins; D012269:Ribosomal Proteins; C087589:anti-endothelial cell antibody; C031937:phosphoprotein P2, ribosomal; C054675:ribosomal protein P0; D004247:DNA