title: Mannose-binding lectin serum levels in neonatal sepsis and septic shock.
abstract: OBJECTIVE
  To evaluate mannose-binding lectin (MBL) serum levels as a marker for predicting sepsis, septic shock, and their outcomes in neonates.
  
  
  METHODS
  A prospective study was conducted on 62 neonates (27 preterm and 35 full term) with culture-proven sepsis and 35 controls. Serum levels of MBL were measured by immunoassay.
  
  
  RESULTS
  Of 62 infants with positive blood cultures (Gram-negative = 44 and Gram-positive = 18), 11 infants had severe sepsis and 6 neonates developed septic shock. MBL levels were significantly lower in infants with sepsis than in control group (0.39 ± 0.07 vs. 1.34 ± 0.03 μg/ml; p < 0.001). The lowest MBL levels were detected in those infants with septic shock, particularly those who died (p < 0.05). MBL had high sensitivity (96.7), specificity (97.1), positive (98.3), and negative (94.4) predictive values to detect sepsis.
  
  
  CONCLUSIONS
  Low MBL serum levels could be considered as sensitive and specific marker for predicting sepsis, septic shock, and their clinical outcomes in newborn infants.
authors.affiliation: Department of Pediatrics, King Khalid University, Abha, Saudi Arabia. walidabdo2020@gmail.com
authors.forename: Walid Abdel
authors.initials: WA
authors.lastname: Wahab Mohamed
authors.forename: Mohamed Abdullatif
authors.initials: MA
authors.lastname: Saeed
mesh_terms: D001724:Birth Weight / Q000502:physiology; D016022:Case-Control Studies; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000150:complications / Q000453:epidemiology; D016908:Gram-Positive Bacterial Infections / Q000097:blood / Q000150:complications / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D007234:Infant, Premature / Q000097:blood; D007235:Infant, Premature, Diseases / Q000097:blood / Q000453:epidemiology; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D008297:Male; D037601:Mannose-Binding Lectin / Q000032:analysis / Q000097:blood*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000453:epidemiology; D012529:Saudi Arabia / Q000453:epidemiology; D018805:Sepsis / Q000097:blood* / Q000151:congenital / Q000175:diagnosis / Q000453:epidemiology; D012772:Shock, Septic / Q000097:blood* / Q000151:congenital / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D037601:Mannose-Binding Lectin