title: Sentinel lymph node biopsy and survival in elderly patients with cutaneous melanoma.
abstract: BACKGROUND
  Sentinel lymph node biopsy (SNB) is a widely adopted staging procedure in patients with cutaneous melanoma. The benefits of SNB have not been evaluated thoroughly in older age groups.
  
  
  METHODS
  This was a two-centre retrospective observational study of patients with melanoma aged at least 70 years undergoing SNB.
  
  
  RESULTS
  A total of 423 patients were included. SNB was successful in 405 patients (95·7 per cent), of whom 88 (21·7 per cent) had sentinel node metastasis. During a median follow-up of 2·5 years, recurrence developed in 80 patients (18·9 per cent). Nodal recurrence developed in eight sentinel node-negative patients, giving a false-negative rate of 8·3 per cent, a sensitivity of 91·7 per cent and an overall diagnostic accuracy of 98·0 per cent. A total of 46 patients (10·9 per cent) died from melanoma and 42 (9·9 per cent) from other causes. At 5 years, the relapse-free survival rate was 80·0 per cent in sentinel node-negative patients and 39 per cent in node-positive patients; cancer-specific survival rates were 88·6 per cent and 46 per cent respectively (P < 0·001). In multivariable analysis, sentinel node metastasis (P < 0·001), a Breslow thickness of at least 2·0 mm (P = 0·007) and presence of ulceration (P = 0·012) were independent prognostic factors for cancer-specific survival.
  
  
  CONCLUSIONS
  SNB is a feasible and accurate technique for detecting nodal metastases in older patients with melanoma. Sentinel node status is the most important predictor of cancer-specific outcome in the elderly.
authors.affiliation: Department of Surgery, Turku University Hospital, Turku, Finland. ilkka.koskivuo@tyks.fi
authors.forename: I
authors.initials: I
authors.lastname: Koskivuo
authors.forename: M
authors.initials: M
authors.lastname: Hernberg
authors.forename: P
authors.initials: P
authors.lastname: Vihinen
authors.forename: S
authors.initials: S
authors.lastname: Virolainen
authors.forename: L
authors.initials: L
authors.lastname: Talve
authors.forename: M
authors.initials: M
authors.lastname: Seppänen
authors.forename: T
authors.initials: T
authors.lastname: Vahlberg
authors.forename: T
authors.initials: T
authors.lastname: Jahkola
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000401:mortality; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology*