title: XPD Lys751Gln polymorphism and esophageal cancer risk: a meta-analysis involving 2288 cases and 4096 controls.
abstract: OBJECTIVE
  To evaluate the association between xeroderma pigmentosum group D (XPD), genetic polymorphism Lys751Gln and esophageal cancer risk.
  
  
  METHODS
  We searched PubMed up to September 1, 2010 to identify eligible studies. A total of 10 case-control studies including 2288 cases and 4096 controls were included in the meta-analysis. Statistical analysis was performed with Review Manage version 4.2. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.
  
  
  RESULTS
  The results suggested that there is no significant association between XPD Lys751Gln polymorphism and esophageal cancer susceptibility in the overall population. However, in subgroup analysis by histology type, a significant association was found between XPD Lys751Gln polymorphism and esophageal adenocarcinoma (for CC vs AA: OR = 1.25, 95% CI = 1.01-1.55, P = 0.05 for heterogeneity).
  
  
  CONCLUSIONS
  Our meta-analysis suggested that XPD Lys751Gln polymorphism may be associated with increased risk of esophageal adenocarcinoma.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yuan
authors.forename: Dan
authors.initials: D
authors.lastname: Cui
authors.forename: Er-Jiang
authors.initials: EJ
authors.lastname: Zhao
authors.forename: Chen-Zhi
authors.initials: CZ
authors.lastname: Jia
authors.forename: Li-Dong
authors.initials: LD
authors.lastname: Wang
authors.forename: Wei-Quan
authors.initials: WQ
authors.lastname: Lu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human