title: TdaA regulates Tropodithietic acid synthesis by binding to the tdaC promoter region.
abstract: Silicibacter sp. TM1040, a member of the marine Roseobacter clade, produces the antibiotic and quorum signaling molecule tropodithietic acid (TDA), encoded by tdaABCDEF. Here, we showed that an LysR-type transcriptional regulator, TdaA, is a positive regulator of tdaCDE gene expression and binds to the tdaC promoter region.
authors.affiliation: Department of Marine Biotechnology, University of Maryland Baltimore County, and Institute of Marine and Environmental Technology, Baltimore, MD 21202, USA.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Geng
authors.forename: Robert
authors.initials: R
authors.lastname: Belas
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001665:Binding Sites; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D041902:Rhodobacteraceae / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D014334:Tropolone / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; C527336:tropodithietic acid; D014334:Tropolone