title: Severe sorafenib-induced hand-foot skin reaction.
abstract: Sorafenib is a new drug, multikinase inhibitor, which has been recently approved for the treatment of metastatic renal cell carcinoma and hepatocellular carcinoma. Up to 90 percent of patients receiving this drug have been reported to develop dermatological symptoms. Recently, it has been suggested that the appearance of skin toxicity during therapy may indicate antitumor activity. We report a new case of sorafenib-induced severe hand-foot skin reaction, which hindered the patient's normal life. The reaction was successfully treated with topical costicosteroids and discontinuation of sorafenib. However, the patient died one month later.
authors.forename: L
authors.initials: L
authors.lastname: Cuesta
authors.forename: I
authors.initials: I
authors.lastname: Betlloch
authors.forename: F
authors.initials: F
authors.lastname: Toledo
authors.forename: N
authors.initials: N
authors.lastname: Latorre
authors.forename: A
authors.initials: A
authors.lastname: Monteagudo
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001557:Benzenesulfonates / Q000009:adverse effects* / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000556:secondary; D002990:Clobetasol / Q000627:therapeutic use; D018450:Disease Progression; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology*; D017809:Fatal Outcome; D005533:Foot Dermatoses / Q000139:chemically induced* / Q000188:drug therapy; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D008113:Liver Neoplasms; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011725:Pyridines / Q000009:adverse effects* / Q000627:therapeutic use; D000077157:Sorafenib
chemical_list: D000970:Antineoplastic Agents; D001557:Benzenesulfonates; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib; D002990:Clobetasol