title: Diffusion tensor imaging findings are not strongly associated with postconcussional disorder 2 months following mild traumatic brain injury.
abstract: OBJECTIVE
  To examine the relation between diffusion tensor imaging (DTI) of the corpus callosum and postconcussion symptom reporting following mild traumatic brain injury (MTBI).
  
  
  METHODS
  Sixty patients with MTBI and 34 patients with orthopedic/soft-tissue injuries (Trauma Controls) prospectively enrolled from consecutive admissions to a level 1 trauma center.
  
  
  METHODS
  Diffusion tensor imaging of the corpus callosum was undertaken using a Phillips 3T scanner at 6 to 8 weeks postinjury. Participants also completed a postconcussion symptom checklist. The MTBI group was divided into 2 subgroups based on the International Classification of Diseases, Tenth Revision symptom criteria for postconcussion disorder (PCD): PCD Present (n = 21), PCD Absent (n = 39).
  
  
  METHODS
  Measures of fractional anisotropy and mean diffusivity for the genu, body, and splenium of the corpus callosum. Participants also completed the British Columbia Post-Concussion Symptom Inventory.
  
  
  RESULTS
  The MTBI group reported more postconcussion symptoms than the trauma controls. There were no significant differences between MTBI and trauma control groups on all DTI measures. In the MTBI sample, there were no significant differences on all DTI measures between those who did and did not meet the International Classification of Diseases, Tenth Revision research criteria for postconcussion disorder.
  
  
  CONCLUSIONS
  These data do not support an association between white matter integrity in the corpus callosum and self-reported postconcussion syndrome 6 to 8 weeks post-MTBI.
authors.affiliation: Defense and Veterans Brain Injury Center, Walter Reed Army Medical Center, Washington, DC 20307, USA. rlange@dvbic.org
authors.forename: Rael T
authors.initials: RT
authors.lastname: Lange
authors.forename: Grant L
authors.initials: GL
authors.lastname: Iverson
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Brubacher
authors.forename: Burkhard
authors.initials: B
authors.lastname: Mädler
authors.forename: Manraj K
authors.initials: MK
authors.lastname: Heran
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016880:Anisotropy; D001930:Brain Injuries / Q000150:complications* / Q000175:diagnosis*; D001955:British Columbia; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000293:injuries / Q000473:pathology; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D009483:Neuropsychological Tests; D038223:Post-Concussion Syndrome / Q000175:diagnosis* / Q000209:etiology*; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D013997:Time Factors; D014193:Trauma Centers; D055815:Young Adult