title: The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats.
abstract: Magnesium sulfate (MgSO₄) has been used to prevent seizures in eclampsia. This study examined the central effects of MgSO₄ on different types of pentylenetetrazole (PTZ)-induced seizures. Male Wistar rats were submitted to intracerebroventricular (ICV) administration of MgSO₄ at different doses followed by intraperitoneal administration of PTZ. The latency to the onset of the first seizure induced by PTZ was significantly increased by ICV administration of MgSO₄ at a dose of 100 µg compared to the control treatment. In addition, the total period during which animals presented with seizures was significantly reduced at this dose of MgSO₄. Furthermore, the latency to the onset of the first partial complex seizure was significantly increased by the lowest dose of MgSO₄. However, a high dose of MgSO₄ had no effect or even potentiated the effect of PTZ. These results suggest that, depending on the dose, MgSO₄ may be important in prevention of epileptic seizures.
authors.affiliation: Departamento de Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, ES, Brazil. luzienedb@ig.com.br
authors.forename: Luziene Dalmaschio Biasutti de
authors.initials: LD
authors.lastname: Oliveira
authors.forename: Roney Welinton Dias de
authors.initials: RW
authors.lastname: Oliveira
authors.forename: Henrique de Azevedo
authors.initials: Hde A
authors.lastname: Futuro Neto
authors.forename: Ester Miyuki
authors.initials: EM
authors.lastname: Nakamura-Palacios
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D007276:Injections, Intraventricular; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D008278:Magnesium Sulfate; D010433:Pentylenetetrazole