title: Principles of unconventional myosin function and targeting.
abstract: Unconventional myosins are a superfamily of actin-based motors implicated in diverse cellular processes. In recent years, much progress has been made in describing their biophysical properties, and headway has been made into analyzing their cellular functions. Here, we focus on the principles that guide in vivo motor function and targeting to specific cellular locations. Rather than describe each motor comprehensively, we outline the major themes that emerge from research across the superfamily and use specific examples to illustrate each. In presenting the data in this format, we seek to identify open questions in each field as well as to point out commonalities between them. To advance our understanding of myosins' roles in vivo, clearly we must identify their cellular cargoes and the protein complexes that regulate motor attachment to fully appreciate their functions on the cellular and developmental levels.
authors.affiliation: Department of Biochemistry, Stanford University, Stanford, California 94305, USA.
authors.forename: M Amanda
authors.initials: MA
authors.lastname: Hartman
authors.forename: Dina
authors.initials: D
authors.lastname: Finan
authors.forename: Sivaraj
authors.initials: S
authors.lastname: Sivaramakrishnan
authors.forename: James A
authors.initials: JA
authors.lastname: Spudich
mesh_terms: D000199:Actins / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002448:Cell Adhesion; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000378:metabolism* / Q000648:ultrastructure; D009218:Myosins / Q000378:metabolism* / Q000648:ultrastructure; D020033:Protein Isoforms / Q000378:metabolism* / Q000648:ultrastructure; D011499:Protein Processing, Post-Translational
chemical_list: D000199:Actins; D008563:Membrane Lipids; D008840:Microfilament Proteins; D020409:Molecular Motor Proteins; D020033:Protein Isoforms; D020558:GTP Phosphohydrolases; D009218:Myosins; D002118:Calcium