title: Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.
abstract: A series of chalcone derivatives bearing the 2,4-thiazolidinedione and benzoic acid moieties (8a-s) were synthesized, characterized, and evaluated for their anti-bacterial activity. Among the tested compounds, the most effective were 8a, 8h, 8k, 8n and 8q with MIC value in the range of 0.5-4 μg/mL against six Gram-positive bacteria (including multidrug-resistant clinical isolates). None of the compounds exhibited any activity against the Gram-negative bacteria Escherichia coli 1356 and E. coli 1682 at 64 μg/mL.
authors.affiliation: Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, PR China.
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Liu
authors.forename: Chang-Ji
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Liang-Peng
authors.initials: LP
authors.lastname: Sun
authors.forename: Xue-Kun
authors.initials: XK
authors.lastname: Liu
authors.forename: Hu-Ri
authors.initials: HR
authors.lastname: Piao
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D019817:Benzoic Acid / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D002599:Chalcone / Q000138:chemical synthesis* / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D045162:Thiazolidinediones / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D045162:Thiazolidinediones; D002599:Chalcone; D019817:Benzoic Acid; C089946:2,4-thiazolidinedione