title: Recurrent early pregnancy loss and consanguinity in Omani couples.
abstract: Consanguinity is common in Arab countries. The Sultanate of Oman has a relatively small population with a high prevalence of consanguineous marriages. This is a retrospective study of women who had three or more consecutive miscarriages between January 2002 and December 2008, investigated in the non-pregnant state. Age, parity, menstrual history, number of miscarriages, personal and family history, history of consanguinity and investigations were collected for 141 patients. The mean number of miscarriages was 3.4; 53% of the women had a consanguineous marriage, 42% were non-consanguineous and in 5% the marital interrelationship was unknown. There was no significant difference in the prevalence of parental karyotype abnormalities, anticardiolipin antibodies, antinuclear antibodies, thyroid disorders, or lupus between the consanguineous and non-consanguineous couples. Consanguinity appeared not to play a significant role in the etiology of recurrent spontaneous miscarriage.
authors.affiliation: Department of Obstetrics and Gynecology Department of Genetics Department of Family Medicine and Community Health, Sultan Qaboos University, Muscat, Sultanate of Oman. gowrie61@hotmail.com
authors.forename: Vaidyanathan
authors.initials: V
authors.lastname: Gowri
authors.forename: Achandira Muthappa
authors.initials: AM
authors.lastname: Udayakumar
authors.forename: Wafa
authors.initials: W
authors.lastname: Bsiso
authors.forename: Yahaya
authors.initials: Y
authors.lastname: Al Farsi
authors.forename: Kuntal
authors.initials: K
authors.lastname: Rao
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology* / Q000209:etiology; D015331:Cohort Studies; D003241:Consanguinity; D003906:Developing Countries; D005191:Family Characteristics / Q000208:ethnology; D005260:Female; D005865:Gestational Age; D006801:Humans; D009850:Oman / Q000453:epidemiology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D015995:Prevalence; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment