title: Effects of essential fatty acid supplementation in dogs with idiopathic epilepsy: a clinical trial.
abstract: The effects of essential fatty acid supplementation (EFA) on the control of idiopathic epilepsy in dogs were investigated in a blinded, placebo-controlled trial. Fifteen dogs were treated with triple purified Ω-3 oil containing 400 mg eicosapentaenoic acid, 250 mg docosahexaenoic acid and 22 mg vitamin E per 1.5 mL at a dose of 1.5 mL/10 kg once daily for 12 weeks, followed by a 12 week placebo period of supplementation with olive oil. Owners recorded seizure frequency and severity and any adverse events. EFA supplementation did not reduce seizure frequency or severity in dogs with idiopathic epilepsy.
authors.affiliation: Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Matthews
authors.forename: Nicolas
authors.initials: N
authors.lastname: Granger
authors.forename: James
authors.initials: J
authors.lastname: Wood
authors.forename: Barbara
authors.initials: B
authors.lastname: Skelly
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004827:Epilepsy / Q000188:drug therapy / Q000662:veterinary*; D005228:Fatty Acids, Essential / Q000008:administration & dosage / Q000627:therapeutic use*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D005228:Fatty Acids, Essential; D015525:Fatty Acids, Omega-3; D014810:Vitamin E