title: Predicting mixture toxicity of seven phenolic compounds with similar and dissimilar action mechanisms to Vibrio qinghaiensis sp.nov.Q67.
abstract: The predictions of mixture toxicity for chemicals are commonly based on two models: concentration addition (CA) and independent action (IA). Whether the CA and IA can predict mixture toxicity of phenolic compounds with similar and dissimilar action mechanisms was studied. The mixture toxicity was predicted on the basis of the concentration-response data of individual compounds. Test mixtures at different concentration ratios and concentration levels were designed using two methods. The results showed that the Weibull function fit well with the concentration-response data of all the components and their mixtures, with all relative coefficients (Rs) greater than 0.99 and root mean squared errors (RMSEs) less than 0.04. The predicted values from CA and IA models conformed to observed values of the mixtures. Therefore, it can be concluded that both CA and IA can predict reliable results for the mixture toxicity of the phenolic compounds with similar and dissimilar action mechanisms.
authors.affiliation: Beijing Key Laboratory of Water Resources & Environmental Engineering, China University of Geosciences, Beijing 100083, PR China.
authors.forename: Wei Ying
authors.initials: WY
authors.lastname: Huang
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Shu Shen
authors.initials: SS
authors.lastname: Liu
authors.forename: Hui Lin
authors.initials: HL
authors.lastname: Ge
authors.forename: Hong Han
authors.initials: HH
authors.lastname: Chen
mesh_terms: D001592:Benzyl Alcohols / Q000737:chemistry / Q000633:toxicity; D002733:Chlorophenols / Q000737:chemistry / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004785:Environmental Pollutants / Q000633:toxicity*; D006873:Hydroquinones / Q000737:chemistry / Q000633:toxicity; D009596:Nitrophenols / Q000737:chemistry / Q000633:toxicity; D010636:Phenols / Q000737:chemistry / Q000633:toxicity*; D010696:Phloroglucinol / Q000737:chemistry / Q000633:toxicity; D012118:Resorcinols / Q000737:chemistry / Q000633:toxicity; D014733:Vibrio / Q000187:drug effects*
chemical_list: D001592:Benzyl Alcohols; D002733:Chlorophenols; D004785:Environmental Pollutants; D006873:Hydroquinones; D009596:Nitrophenols; D010636:Phenols; D012118:Resorcinols; D010696:Phloroglucinol; C010631:salicyl alcohol; C031927:hydroquinone; C548837:2-chloro-4-nitrophenol; C031389:resorcinol; C030682:3-chlorophenol