title: Three new megastigmane glucopyranosides from the Cardamine komarovii.
abstract: Three new megastigmane glucopyranosides, komaroveside A [(3S,4R,5Z,7E)-3,4-dihydroxy-5,7-megastigmadien-9-one-3-O-β-D-glucopyranoside] (1), komaroveside B [(3S,4S,5S,6R,7E)-5,6-epoxy-3,4-dihydroxy-7-megastigmen-9-one-3-O-β-D-glucopyranoside] (2) and komaroveside C [(3S,4S,5S,6R,7E,9S)-5,6-epoxy-3,4,9-trihydroxy-7-megastigmen-3-O-β-D-glucopyranoside] (3) were isolated, together with eight known compounds, from Cardamine komarovii. The identification of these compounds and the elucidation of their structures were based on 1D- and 2D-NMR spectral data analysis. The isolated compounds were tested for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, HCT15) in vitro using the sulforhodamine B bioassay.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
authors.forename: Il Kyun
authors.initials: IK
authors.lastname: Lee
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Seung Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D031217:Cardamine / Q000737:chemistry*; D045744:Cell Line, Tumor; D003512:Cyclohexanones / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D045792:Norisoprenoids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: C561140:(3S,4R,5Z,7E)-3,4-dihydroxy-5,7-megastigmadien-9-one-3-O-beta-D-glucopyranoside; C561141:(3S,4S,5S,6R,7E)-5,6-epoxy-3,4-dihydroxy-7-megastigmen-9-one-3-O-beta-D-glucopyranoside; C561142:(3S,4S,5S,6R,7E,9S)-5,6-epoxy-3,4,9-trihydroxy-7-megastigmen-3-O-beta-D-glucopyranoside; D000972:Antineoplastic Agents, Phytogenic; D003512:Cyclohexanones; D005960:Glucosides; D045792:Norisoprenoids; C413264:megastigmane