title: Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009.
abstract: We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.
authors.affiliation: Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy. simona.digiambenedetto@rm.unicatt.it
authors.forename: S
authors.initials: S
authors.lastname: Di Giambenedetto
authors.forename: M
authors.initials: M
authors.lastname: Prosperi
authors.forename: I
authors.initials: I
authors.lastname: Fanti
authors.forename: B
authors.initials: B
authors.lastname: Bruzzone
authors.forename: S
authors.initials: S
authors.lastname: Paolucci
authors.forename: G
authors.initials: G
authors.lastname: Penco
authors.forename: G
authors.initials: G
authors.lastname: Meini
authors.forename: A
authors.initials: A
authors.lastname: Di Biagio
authors.forename: E
authors.initials: E
authors.lastname: Paolini
authors.forename: V
authors.initials: V
authors.lastname: Micheli
authors.forename: P
authors.initials: P
authors.lastname: Meraviglia
authors.forename: P
authors.initials: P
authors.lastname: Castelli
authors.forename: P
authors.initials: P
authors.lastname: Corsi
authors.forename: A
authors.initials: A
authors.lastname: Gonnelli
authors.forename: M
authors.initials: M
authors.lastname: Fabbiani
authors.forename: M
authors.initials: M
authors.lastname: Zazzi
authors.forename: A
authors.initials: A
authors.lastname: De Luca
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D016208:Databases, Factual; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1; D006801:Humans; D007558:Italy; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017211:Treatment Failure
chemical_list: D019380:Anti-HIV Agents