title: Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention.
abstract: Over the past 10 years, dissemination of Klebsiella pneumoniae carbapenemase (KPC) has led to an increase in the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Infections caused by CRE have limited treatment options and have been associated with high mortality rates. In the previous year, other carbapenemase subtypes, including New Delhi metallo-β-lactamase, have been identified among Enterobacteriaceae in the United States. Like KPC, these enzymes are frequently found on mobile genetic elements and have the potential to spread widely. As a result, preventing both CRE transmission and CRE infections have become important public health objectives. This review describes the current epidemiology of CRE in the United States and highlights important prevention strategies.
authors.affiliation: Epidemic Intelligence Service, Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS A-35, Atlanta, GA 30333, USA. ngupta1@cdc.gov
authors.forename: Neil
authors.initials: N
authors.lastname: Gupta
authors.forename: Brandi M
authors.initials: BM
authors.lastname: Limbago
authors.forename: Jean B
authors.initials: JB
authors.lastname: Patel
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Kallen
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D015780:Carbapenems / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae; D004756:Enterobacteriaceae Infections / Q000201:enzymology / Q000453:epidemiology* / Q000382:microbiology* / Q000517:prevention & control; D006801:Humans; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C531581:carbapenemase-2, Klebsiella pneumoniae