title: Hematologic, serologic, and histologic profile of aged Siberian hamsters (Phodopus sungorus).
abstract: Biologic samples from 18 (12 female, 6 male) Siberian hamsters (Phodopus sungorus) representing an aged colony (17 to 27 mo) were examined. Values for CBC and serum biochemical parameters were determined, and macroscopic and microscopic pathologic evaluations were performed. Blood urea nitrogen levels were significantly higher in male (54.2 ± 14 mg/dL) compared with female (35.3 ± 22 mg/dL) hamsters and correlated histologically with a higher incidence of chronic glomerulonephropathy in males (5 of 6 males; 0 of 12 females). All 18 hamsters had histologic evidence of follicular mite infestation. Half (6 of 12) of the female hamsters showed cystic rete ovarii. Other histologic findings included thymic or thyroid branchial cysts (3 of 18), focal enteritis (2 of 18), and single cases of hepatic hemangiosarcoma, renal adenoma, subcutaneous mast cell tumor, cutaneous sebaceous adenoma, cutaneous trichofolliculoma, squamous papilloma of the nonglandular stomach, epididymal cholesteatoma, pyometra, and pituitary craniopharyngeal cyst. This study is the first published report of hematologic and serum chemical values for any population of Siberian hamsters and the first published report showing a potential male predisposition for chronic progressive glomerulonephropathy and a potential female predisposition for cystic rete ovarii.
authors.affiliation: Department of Comparative Medicine, School of Medicine, Stanford University, Stanford, California, USA. gpmckeon@stanford.edu
authors.forename: Gabriel P
authors.initials: GP
authors.lastname: McKeon
authors.forename: Claude M
authors.initials: CM
authors.lastname: Nagamine
authors.forename: Norman F
authors.initials: NF
authors.lastname: Ruby
authors.forename: Richard H
authors.initials: RH
authors.lastname: Luong
mesh_terms: D000375:Aging / Q000097:blood / Q000473:pathology; D000818:Animals; D000830:Animals, Laboratory / Q000097:blood; D001806:Blood Urea Nitrogen; D015984:Causality; D002908:Chronic Disease; D006224:Cricetinae / Q000097:blood*; D005260:Female; D005921:Glomerulonephritis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008924:Mite Infestations / Q000453:epidemiology / Q000662:veterinary*; D010048:Ovarian Cysts / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D017111:Phodopus / Q000097:blood*; D015995:Prevalence; D012376:Rodent Diseases / Q000097:blood / Q000473:pathology; D012737:Sex Factors