title: Prospective, randomized comparison of two small-bowel capsule endoscopy systems in patients with obscure GI bleeding.
abstract: BACKGROUND
  Video capsule endoscopy is the first-intention examination in patients with obscure GI bleeding. The new MiroCam capsule, when using electric-field propagation for transmission, has been poorly evaluated in a clinical setting, in contrast with the PillCam SB2 capsule.
  
  
  OBJECTIVE
  To evaluate the diagnostic concordance (κ value) between PillCam SB2 and MiroCam capsule examinations performed in the same patients.
  
  
  METHODS
  Prospective, randomized study in 7 endoscopy units.
  
  
  METHODS
  Eighty-three consecutive patients, ingesting the 2 capsules at a 1-hour interval.
  
  
  RESULTS
  Seventy-three patients were analyzed (10 technical issues). There were 31 concordant negative cases (42.4%) and 30 concordant positive cases (41.1%). The study showed satisfactory diagnostic concordance between the 2 systems (κ = 0.66). In 12 patients (16.4%), the final diagnosis was different: 9 patients had positive findings on MiroCam examination but no image detected with PillCam SB2, 2 had positive findings on PillCam examination only, and 1 patient had 2 different diagnoses. A positive diagnosis was obtained in 46.6% and 56.2% of patients with PillCam SB2 and MiroCam capsule, respectively, so that the procedures identified 78.6% and 95.2% of positive cases, respectively (P = .02). Small-bowel transit time and capsule reading time were significantly longer in MiroCam procedures.
  
  
  CONCLUSIONS
  Technical failures possibly related to capsule interference.
  
  
  CONCLUSIONS
  This study shows at least comparable efficiency of the MiroCam compared with the PillCam SB2 capsule system for the diagnosis of obscure GI bleeding.
authors.affiliation: Gastroenterology Department, Edouard Herriot Hospital, Lyon, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Pioche
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Gaudin
authors.forename: Bernard
authors.initials: B
authors.lastname: Filoche
authors.forename: Philippe
authors.initials: P
authors.lastname: Jacob
authors.forename: Hervé
authors.initials: H
authors.lastname: Lamouliatte
authors.forename: Marie-George
authors.initials: MG
authors.lastname: Lapalus
authors.forename: Clotilde
authors.initials: C
authors.lastname: Duburque
authors.forename: Ulrikka
authors.initials: U
authors.lastname: Chaput
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ben Soussan
authors.forename: Jacques
authors.initials: J
authors.lastname: Daudet
authors.forename: Romain
authors.initials: R
authors.lastname: Tournan
authors.forename: Marianne
authors.initials: M
authors.lastname: Gaudric
authors.forename: Joel
authors.initials: J
authors.lastname: Edery
authors.forename: Christophe
authors.initials: C
authors.lastname: Cellier
authors.forename: Pierre-Nicolas
authors.initials: PN
authors.lastname: Halluin
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Saurin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053705:Capsule Endoscopes; D016009:Chi-Square Distribution; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult