title: Impact of coronary calcium on outcome following sirolimus-eluting stent implantation.
abstract: There remain a small but sizable number of patients who develop restenosis after sirolimus-eluting stent (SES) implantation. However, the cause of SES restenosis has not been fully elucidated. The study population consisted of 52 patients with 69 lesions who underwent noninvasive coronary imaging by 64-slice multidetector computed tomography before SES deployment. Agatston calcium scores in target lesions were measured. All patients underwent follow-up coronary angiography at 8 months. Three coronary segments (in stent, proximal edge, and distal edge) were analyzed by quantitative coronary angiography. Agatston calcium score in target lesions averaged 214.7. Late lumen losses in the proximal edge, stent, and distal edge were 0.16 ± 0.45, 0.47 ± 0.58, and 0.07 ± 0.29 mm, respectively. Lesions with restenosis at follow-up showed a trend to produce higher preprocedural calcium scores (629) compared to those without restenosis (153, p = 0.08). There was a significant positive correlation between lesion calcium score and in-stent late lumen loss (r = 0.47, p <0.01). In conclusion, assessment of coronary calcium by multidetector computed tomography might be useful to predict outcomes after SES implantation.
authors.affiliation: Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan. kengo-t@zd5.so-net.ne.jp
authors.forename: Kengo
authors.initials: K
authors.lastname: Tanabe
authors.forename: Satoru
authors.initials: S
authors.lastname: Kishi
authors.forename: Jiro
authors.initials: J
authors.lastname: Aoki
authors.forename: Shuzou
authors.initials: S
authors.lastname: Tanimoto
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Onuma
authors.forename: Sen
authors.initials: S
authors.lastname: Yachi
authors.forename: Masanori
authors.initials: M
authors.lastname: Taniwaki
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Nakajima
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hara
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Isobe
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed