title: Synthesis of substituted 1,4,5,6-tetrahydrocyclopenta[b]pyrroles by platinum-catalyzed cascade cyclization/ring expansion of 2-alkynyl-1-azaspiro[2.3]hexanes.
abstract: The reaction of 2-alkynyl-1-azaspiro[2.3]hexanes with a platinum catalyst is described. 1,4,5,6-Tetrahydrocyclopenta[b]pyrroles having a variety of substituents were conveniently synthesized via a cascade cyclization/ring-expansion process.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan. yoshida@ph.tokushima-u.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Yohei
authors.initials: Y
authors.lastname: Maeyama
authors.forename: Mohammad
authors.initials: M
authors.lastname: Al-Amin
authors.forename: Kozo
authors.initials: K
authors.lastname: Shishido
mesh_terms: D002384:Catalysis; D003500:Cyclization; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D006586:Hexanes / Q000737:chemistry*; D015394:Molecular Structure; D010984:Platinum / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C568058:1,4,5,6-tetrahydrocyclopenta(b)pyrrole; D003517:Cyclopentanes; D006586:Hexanes; D011758:Pyrroles; D013141:Spiro Compounds; D010984:Platinum