title: Solid-state NMR techniques for the structural determination of amyloid fibrils.
abstract: This review discusses the solid-state NMR techniques developed for the study of amyloid fibrils. Literature up to the end of 2010 has been surveyed and the materials are organized according to five categories, viz. homonuclear dipolar recoupling and polarization transfer via J-coupling, heteronuclear dipolar recoupling, correlation spectroscopy, recoupling of chemical shift anisotropy, and tensor correlation. Our emphasis is on the NMR techniques and their practical aspects. The biological implications of the results obtained for amyloid fibrils are only briefly discussed. Our main objective is to showcase the power of NMR in the study of biological unoriented solids.
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei, Taiwan. chanjcc@ntu.edu.tw
authors.forename: Jerry C C
authors.initials: JC
authors.lastname: Chan
mesh_terms: D000465:Algorithms; D000682:Amyloid / Q000737:chemistry*; D000818:Animals; D016880:Anisotropy; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods
chemical_list: D000682:Amyloid