title: Regulation of obesity and lipid disorders by extracts from Angelica acutiloba root in high-fat diet-induced obese rats.
abstract: The aim of this study was to investigate the antiobesity and antihyperlipidemic effects of Angelica acutiloba root (Japanese Dong Quai). High-fat diet (HFD)-induced obese rats were treated orally with the polyphenolic-rich extract of Angelica acutiloba root (AARE) once daily for 8 weeks. The AARE (300 mg/kg per day) supplementation significantly lowered body weight gain, visceral fat-pad weights and plasma lipid levels, as well as the coronary artery risk index and the atherogenic index of HFD-fed rats. The AARE caused dose related reductions in the hepatic triglyceride and cholesterol contents, as well as lowered hepatic lipid droplet accumulation and epididymal adipocyte size in the HFD-fed rats. The AARE reversed the HFD-induced down-regulation of the hepatic peroxisome proliferator activated receptor-α (PPARα). The HFD-induced decreases of the hepatic protein level of acyl-CoA oxidase (ACO), and the cytochrome P450 isoform 4A1 (CYP4A1) was up-regulated by AARE. The elevated expressions of hepatic sterol regulatory element binding proteins (SREBPs) of HFD-fed rats were lowered by AARE. These results suggest that AARE attenuated visceral fat accumulation and improved hyperlipidemia in HFD-induced obesity by increasing lipid metabolism through the down-regulation of SREBPs and enhanced the expression of ACO and CYP4A1 in the liver, which was likely mediated by up-regulation of the expression of hepatic PPARα.
authors.affiliation: Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yenpu Township, Pingtung Country, Taiwan, R.O.C. iml@mail.tajen.edu.tw
authors.forename: I-Min
authors.initials: IM
authors.lastname: Liu
authors.forename: Thing-Fong
authors.initials: TF
authors.lastname: Tzeng
authors.forename: Shorong-Shii
authors.initials: SS
authors.lastname: Liou
authors.forename: Chia Ju
authors.initials: CJ
authors.lastname: Chang
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D059305:Diet, High-Fat / Q000009:adverse effects; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D050152:Intra-Abdominal Fat / Q000187:drug effects; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts