title: The neural substrates of script knowledge deficits as revealed by a PET study in Huntington's disease.
abstract: BACKGROUND
  Previous neuropsychological investigations have suggested that both the prefrontal cortex and the basal ganglia are involved in the management of script event knowledge required in planning behavior.
  
  
  METHODS
  This study was designated to map, the correlations between resting-state brain glucose utilization as measured by FDG-PET (positron emission tomography) and scores obtained by means of a series of script generation and script sorting tasks in 8 patients with early Huntington's disease.
  
  
  RESULTS
  These patients exhibited a selectively greater impairment for the organizational aspects of scripts compared to the semantic aspects of scripts. We showed significant negative correlations between the number of sequencing, boundary, perseverative and intrusion errors and the metabolism of several cortical regions, not only including frontal, but also posterior regions.
  
  
  CONCLUSIONS
  Our findings suggest that, within the fronto-striatal system, the cortical frontal regions are more crucial in script retrieval and script sequencing than the basal ganglia.
authors.affiliation: Département de Neurologie, CHU Angers, France. PhAllain@chu-angers.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Allain
authors.forename: Véronique
authors.initials: V
authors.lastname: Gaura
authors.forename: Luciano
authors.initials: L
authors.lastname: Fasotti
authors.forename: Valérie
authors.initials: V
authors.lastname: Chauviré
authors.forename: Adriana
authors.initials: A
authors.lastname: Prundean
authors.forename: Clarisse
authors.initials: C
authors.lastname: Sherer-Gagou
authors.forename: Dominique
authors.initials: D
authors.lastname: Bonneau
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Bachoud-Levi
authors.forename: Frédéric
authors.initials: F
authors.lastname: Dubas
authors.forename: Philippe
authors.initials: P
authors.lastname: Remy
authors.forename: Didier
authors.initials: D
authors.lastname: Le Gall
authors.forename: Christophe
authors.initials: C
authors.lastname: Verny
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000378:metabolism / Q000503:physiopathology; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000378:metabolism / Q000503:physiopathology; D006802:Human Activities; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000503:physiopathology*; D008606:Mental Processes / Q000502:physiology*; D008875:Middle Aged; D017072:Neostriatum / Q000378:metabolism / Q000503:physiopathology; D009434:Neural Pathways / Q000378:metabolism / Q000503:physiopathology; D049268:Positron-Emission Tomography; D012016:Reference Values; D012691:Serial Learning / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18