title: Unraveling the enigma: progress towards understanding the coronin family of actin regulators.
abstract: Coronins are a conserved family of actin cytoskeleton regulators that promote cell motility and modulate other actin-dependent processes. Although these proteins have been known for 20 years, substantial progress has been made in the past 5 years towards their understanding. In this review, we examine this progress, place it into the context of what was already known, and pose several questions that remain to be addressed. In particular, we cover the emerging consensus about the role of Type I coronins in coordinating the function of Arp2/3 complex and ADF/cofilin proteins. This coordination plays an important role in leading-edge actin dynamics and overall cell motility. Finally, we discuss the roles played by the more exotic coronins of the Type II and III classes in cellular processes away from the leading edge.
authors.affiliation: Lineberger Comprehensive Cancer Center and Department of Cell & Developmental Biology, Howard Hughes Medical Institute. University of North Carolina at Chapel Hill, USA.
authors.forename: Keefe T
authors.initials: KT
authors.lastname: Chan
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Creed
authors.forename: James E
authors.initials: JE
authors.lastname: Bear
mesh_terms: D051339:Actin Depolymerizing Factors / Q000378:metabolism; D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism; D000199:Actins / Q000378:metabolism*; D000818:Animals; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D051339:Actin Depolymerizing Factors; D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D008840:Microfilament Proteins; C072061:coronin proteins