title: Antibody fragments as tools in crystallography.
abstract: While antibody-based therapeutics have become firmly established as front-line drugs, the use of antibodies as research tools in small molecule drug discovery is still in its infancy. In this review we focus on the use of antibody fragments as crystallization chaperones to aid the structural determination of otherwise 'uncrystallizable' or 'undruggable' target proteins. We also highlight a potential application for this technology, in which antibody-mediated structures may be used to inform the design of new chemical entities.
authors.affiliation: Department of Structural Biology, UCB, Slough, UK.
authors.forename: L
authors.initials: L
authors.lastname: Griffin
authors.forename: A
authors.initials: A
authors.lastname: Lawson
mesh_terms: D003461:Crystallography / Q000379:methods*; D055808:Drug Discovery / Q000379:methods; D007128:Immunoglobulin Fragments / Q000737:chemistry / Q000494:pharmacology*; D055550:Protein Stability / Q000187:drug effects*
chemical_list: D007128:Immunoglobulin Fragments