title: Association between vascular cell adhesion molecule 1 and radiographic hand osteoarthritis.
abstract: BACKGROUND
  A recent study showed that the level of soluble Vascular Cell Adhesion Molecule 1 (VCAM-1) emerged as a strong and independent predictor of the risk of hip and knee joint replacement due to severe osteoarthritis (OA). Therefore, we hypothesized that soluble VCAM-1 level can be associated with prevalence and severity of radiographic hand OA.
  
  
  OBJECTIVE
  To evaluate the association between soluble VCAM-1, and radiographic hand OA in a large community-based sample.
  
  
  METHODS
  The study population comprised Chuvashians (473 males age 45.90±17.16; and 451 females, age 46.18±16.70 years). OA was evaluated for 14 joints of each hand using Kellgren and Lawrence (K-L). OA was characterised by the number of affected joints and by the presence of at least one affected joint. The VCAM-1 level was determined by a sandwichenzyme immunoassay technique using ELISA-OSTEO kit. Statistical analyses included multiple linear and logistic regressions.
  
  
  RESULTS
  The linear regression model showed a significant association of a number of affected joints with VCAM-1 level (p=0.004) after adjustment for age, sex, BMI. In the logistic regression model the level of association between the presence of at least one affected joint and soluble VCAM-1 level was p=0.070 (OR(95%CI): 1.003 (1.000, 1.007)).
  
  
  CONCLUSIONS
  In this cross-sectional population-based study, we found that the serum level of soluble VCAM-1 level is positively associated with the number of affected joints of hand OA.
authors.affiliation: Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel. kleonid@bgu.ac.il
authors.forename: L
authors.initials: L
authors.lastname: Kalichman
authors.forename: I
authors.initials: I
authors.lastname: Pantsulaia
authors.forename: E
authors.initials: E
authors.lastname: Kobyliansky
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D050823:Hand Joints / Q000000981:diagnostic imaging*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood* / Q000000981:diagnostic imaging*; D011859:Radiography; D012720:Severity of Illness Index; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019010:Vascular Cell Adhesion Molecule-1