title: [Histopathology of coeliac disease].
abstract: Coeliac disease is a common disease, affecting 1% of the population. Clinical manifestations are multiple. The diagnosis requires serologic testing and a duodenal biopsy that shows the characteristic findings of intraepithelial lymphocytosis, crypt hyperplasia and villous atrophy, and a positive response to a gluten-free diet. In most patients, the histological diagnosis is easily established. Pitfalls in the pathological diagnosis include a poorly orientated biopsy specimen, either an inadequate biopsy sampling in patients with patchy villous atrophy and the other causes of villous atrophy. A non-response to the gluten-free diet needs to reassess first, the initial diagnosis, second to be sure of the gluten-free diet adherence, and third, to exclude malignant complications such as refractory celiac disease or enteropathy-associated T-cell lymphoma.
authors.affiliation: Service de pathologie, université Paris Descartes, hôpital Necker-Enfants-Malades, AP-HP, 149, rue de Sèvres, 75743 Paris cedex 15, France.
authors.forename: V
authors.initials: V
authors.lastname: Verkarre
authors.forename: N
authors.initials: N
authors.lastname: Brousse
mesh_terms: D001706:Biopsy; D002446:Celiac Disease / Q000150:complications / Q000473:pathology*; D018450:Disease Progression; D058527:Enteropathy-Associated T-Cell Lymphoma / Q000209:etiology / Q000276:immunology; D005756:Gastritis / Q000209:etiology / Q000276:immunology; D006801:Humans; D007422:Intestines / Q000276:immunology / Q000473:pathology; D017410:Practice Guidelines as Topic