title: Divergent synthesis of unsymmetrical annulated biheterocyclic compound libraries: benzimidazole linked indolo-benzodiazepines/quinoxaline.
abstract: Diversity-oriented synthesis of novel benzimidazole linked indolo-benzodiazepine/quinoxaline ring systems using poly(ethylene glycol) as soluble polymer support is described. Commercially available 4-fluoro-3-nitrobenzoic acid and indoline were utilized for the construction of these annulated biheterocyclic compound libraries having multiple privileged structures with three-point structural diversity. A reagent based diversification approach coupled with the Pictet-Spengler-type condensation was used to construct the tetracyclic indolo-benzodiazepines/quinoxalines on substituted benzimidazoles.
authors.affiliation: Laboratory of Combinatorial Drug Discovery, Department of Applied Chemistry National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Li-Hsun
authors.initials: LH
authors.lastname: Chen
authors.forename: Chia-Mao
authors.initials: CM
authors.lastname: Chang
authors.forename: Deepak B
authors.initials: DB
authors.lastname: Salunke
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis*; D001569:Benzodiazepines / Q000138:chemical synthesis*; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis*; D015394:Molecular Structure; D011810:Quinoxalines / Q000138:chemical synthesis*; D054852:Small Molecule Libraries / Q000138:chemical synthesis*
chemical_list: D001562:Benzimidazoles; D006576:Heterocyclic Compounds, 4 or More Rings; D011810:Quinoxalines; D054852:Small Molecule Libraries; D001569:Benzodiazepines