title: Late vitamin K deficiency bleeding leading to a diagnosis of cystic fibrosis: a case report.
abstract: Vitamin K deficiency bleeding (VKDB) in infants still occurs despite worldwide use of prophylaxis. Clinical manifestations can be dramatic with over 50% of patients presenting with intracranial haemorrhage and a mortality rate of 20% in late vitamin K deficiency bleeding. Special attention should be given to infants with a high risk profile (preterm, breast feeding, cholestasis, malabsorption). A tentative diagnosis can be made observing quick normalisation of some easy-to-perform haemostatic parameters (PT, aPTT) after administration of vitamin K. Nowadays, VKDB can still be the first clinical sign of diseases causing malabsorption of fat-soluble vitamins. In this case report, VKDB led to the diagnosis of cystic fibrosis, the most common fatal autosomal recessive disease among Caucasian people.
authors.affiliation: Laboratory of Clinical Biology, Ziekenhuis Oost-Limburg, Campus St.-Jan, Genk, Belgium. bram_ngo@hotmail.com
authors.forename: B
authors.initials: B
authors.lastname: Ngo
authors.forename: K
authors.initials: K
authors.lastname: Van Pelt
authors.forename: V
authors.initials: V
authors.lastname: Labarque
authors.forename: W
authors.initials: W
authors.lastname: Van De Casseye
authors.forename: J
authors.initials: J
authors.lastname: Penders
mesh_terms: D017668:Age of Onset; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001942:Breast Feeding; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D004333:Drug Administration Routes; D056947:Enzyme Replacement Therapy; D010188:Exocrine Pancreatic Insufficiency / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D005183:Failure to Thrive / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D008111:Liver Function Tests; D008286:Malabsorption Syndromes / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors; D016896:Treatment Outcome; D014812:Vitamin K / Q000008:administration & dosage / Q000378:metabolism; D006475:Vitamin K Deficiency Bleeding / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D014815:Vitamins / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D001779:Blood Coagulation Factors; D014815:Vitamins; D014812:Vitamin K