title: [ABCA1 gene expression in peripheral blood lymphocytes and macrophages in patients with atherosclerosis].
abstract: ABCA1 transporter is known to play important role in the cholesterol transport from peripheral tissues. However its contribution in atherosclerosis development remains not completely understood. Using Real Time PCR, a significant reduction of ABCA1 mRNA level in leukocytes of patients with atherosclerosis was determined when compared with controls. Mean ABCA1 expression levels in leukocytes for the group of patients and for the control group are 0.57 +/- 0.28 and 0.93 +/- 0.14 (p = 0.02). At the same time we detected a significant increase of ABCA1 mRNA level in macrophages of patients when compared with controls. Mean ABCA1 expression levels in macrophages for the group of patients and for the control group are 1.32 +/- 0.10 and 0.90 +/- 0.14 (p = 0.014). In summary, we suggest that expression level of ABCA1 gene may contribute to the development of atherosclerosis.
authors.forename: E P
authors.initials: EP
authors.lastname: Demina
authors.forename: V V
authors.initials: VV
authors.lastname: Miroshnikova
authors.forename: T I
authors.initials: TI
authors.lastname: Rodygina
authors.forename: P S
authors.initials: PS
authors.lastname: Kur'ianov
authors.forename: A G
authors.initials: AG
authors.lastname: Vinogradov
authors.forename: A D
authors.initials: AD
authors.lastname: Denisenko
authors.forename: A L
authors.initials: AL
authors.lastname: Shvartsman
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000328:Adult; D050197:Atherosclerosis / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters