title: Chemistry and biological activity of platinum amidine complexes.
abstract: Platinum amidine complexes represent a new class of potential antitumor drugs that contain the imino moiety HN=C(sp(2)) bonded to the platinum center. They can be related to the iminoether derivatives, which were recently shown to be the first Pt(II) compounds with a trans configuration endowed with anticancer activity. The chemical and biological properties of platinum amidine complexes, and more generally of platinum imino derivatives, can be rationally modified through suitable synthetic procedures with the aim of improving their cytotoxicity and antitumor activity. The addition of protic nucleophiles to nitriles coordinated to platinum in various oxidation states can offer a wide variety of complexes with chemical, structural, and physical properties specifically tuned for a more efficacious biological response.
authors.affiliation: Department of Chemical Processes of Engineering, Padova University, Via F. Marzolo 9, 35131 Padova, Italy.
authors.forename: Rino A
authors.initials: RA
authors.lastname: Michelin
authors.forename: Paolo
authors.initials: P
authors.lastname: Sgarbossa
authors.forename: Silvia Mazzega
authors.initials: SM
authors.lastname: Sbovata
authors.forename: Valentina
authors.initials: V
authors.lastname: Gandin
authors.forename: Cristina
authors.initials: C
authors.lastname: Marzano
authors.forename: Roberta
authors.initials: R
authors.lastname: Bertani
mesh_terms: D000578:Amidines / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D000641:Ammonia / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009570:Nitriles / Q000737:chemistry; D010984:Platinum / Q000737:chemistry*
chemical_list: D000578:Amidines; D000588:Amines; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D009570:Nitriles; D010984:Platinum; D000641:Ammonia