title: [The effects of infrasound on the blood coagulation function of guinea pigs].
abstract: OBJECTIVE
  To study the change of the blood coagulation function of guinea pigs exposed to 16 Hz/120 dB, 16 Hz/125 dB infrasound and to explore the mechanism of circulation system damage.
  
  
  METHODS
  Seventy-two guinea pigs were divided into 3 groups: the control group, the group exposed to 16 Hz/120 dB infrasound for 1.5 h a day and the group exposed to 16 Hz/125 dB infrasound for 1.5 h a day. Each exposure group was divided into 4 sub-groups (8 guinea pigs a sub-group) which were exposed to infrasound for 1, 7, 14 and 21 d, respectively. The coagulation function and serum nitric oxide (NO) were measured for control group and all sub-groups after exposure to infrasound.
  
  
  RESULTS
  The prothrombin time (PT), international normalized ratio (INR) and serum NO of group exposed to 16 Hz/125 dB infrasound were (31.16 ± 3.05) s, 2.53 ± 1.21 and (88.304 ± 52.601) µmol/L, respectively, which were significantly higher than those [(21.36 ± 0.10) s, 1.65 ± 0.07 and (30.943 ± 26.864) µmol/L] of control group (P < 0.05). PT and INR of sub-groups exposed to 16 Hz/125 dB infrasound for 14 and 21 d were significantly higher than those of control group. NO of sub-groups exposed to 16 Hz/125 dB infrasound for 1 week and 2 weeks were significantly higher than that of control group (P < 0.05), but NO of sub-group exposed to 16 Hz/125 dB infrasound for 3 weeks decreased slightly.
  
  
  CONCLUSIONS
  The blood coagulation function of guinea pigs exposed to 16 Hz/125 dB infrasound decreased, PT and INR may be used as the indexes to assess of blood coagulation function change induced by the infrasound exposure.
authors.affiliation: The Department of Cadre Ward, The 306th hospital of PLA, Beijing 100101, China.
authors.forename: Wen-min
authors.initials: WM
authors.lastname: Ma
authors.forename: Peng
authors.initials: P
authors.lastname: Qi
authors.forename: Jian-zhong
authors.initials: JZ
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Yi
authors.forename: Xing-ming
authors.initials: XM
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Rui-gang
authors.initials: RG
authors.lastname: Han
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001790:Blood Physiological Phenomena; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D009622:Noise / Q000009:adverse effects*; D011517:Prothrombin Time
chemical_list: D009569:Nitric Oxide