title: Synthesis, structure and cytotoxicity of 3-C, N, S, Se substituted benzo[b]selenophene derivatives.
abstract: Synthesis, molecular structure and cytotoxic activity of a series of 3-C, N, S, Se substituted benzo[b]selenophene derivatives on human fibrosarcoma HT-1080, mouse hepatoma MG-22A, and mouse fibroblasts 3T3 cell lines are described. The correlation between compound LD(50) 3T3 fibroblast cell line and HT-1080 morphology was shown.
authors.affiliation: Department of Medicinal Chemistry, Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia. pavel.arsenyan@lycos.com
authors.forename: Pavel
authors.initials: P
authors.lastname: Arsenyan
authors.forename: Edgars
authors.initials: E
authors.lastname: Paegle
authors.forename: Sergey
authors.initials: S
authors.lastname: Belyakov
authors.forename: Irina
authors.initials: I
authors.lastname: Shestakova
authors.forename: Elina
authors.initials: E
authors.lastname: Jaschenko
authors.forename: Ilona
authors.initials: I
authors.lastname: Domracheva
authors.forename: Juris
authors.initials: J
authors.lastname: Popelis
mesh_terms: D000165:Acridine Orange / Q000032:analysis; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002244:Carbon / Q000737:chemistry; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005354:Fibrosarcoma / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008856:Microscopy, Fluorescence; D008958:Models, Molecular; D009584:Nitrogen / Q000737:chemistry; D012643:Selenium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000737:chemistry; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013876:Thiophenes; C088015:benzothiophene; D013455:Sulfur; D002244:Carbon; D000165:Acridine Orange; D012643:Selenium; D009584:Nitrogen