title: Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing.
abstract: The pathogenesis of alveolitis is not well known and therefore experimental situations that mimic some features of this disease should be developed.
  
  
  OBJECTIVE
  In this study, the evolution of the experimentally induced infection in rat sockets is characterized, which leads to clinical signs of suppurative alveolitis with remarkable wound healing disturbs.
  
  
  METHODS
  Non-infected (Group I) and experimentally infected sockets in Rattus novergicus (Group II) were histometrically evaluated regarding the kinetics of alveolar healing. In addition, the characterization of the present bacteria in inoculation material and the serum levels of C-reactive protein (CRP) were performed. The detected species were Capnocytophaga ochracea, Fusobacterium nucleatum ss nucleatum, Prevotella melaninogenica, Streptococcus anginosus, Treponema socranskii and Streptococcus sanguis.
  
  
  RESULTS
  All experimentally infected rats developed suppurative alveolitis, showing higher levels of CRP in comparison to those non-infected ones. Furthermore, infected rats presented a significant delayed wound healing as measured by the histometric analysis (higher persistent polymorphonuclear infiltrate and lower density of newly formed bone).
  
  
  CONCLUSIONS
  These findings indicate that rat sockets with experimentally induced infection produced higher levels of serum CRP, showing the potential of disseminated infection and a disturb in the alveolar repair process in an interesting experimental model for alveolitis studies.
authors.affiliation: São Lucas School, Porto Velho, RO, Brazil.
authors.forename: Moacyr Tadeu Vicente
authors.initials: MT
authors.lastname: Rodrigues
authors.forename: Camila Lopes
authors.initials: CL
authors.lastname: Cardoso
authors.forename: Paulo Sérgio Perri de
authors.initials: PS
authors.lastname: Carvalho
authors.forename: Tânia Mary
authors.initials: TM
authors.lastname: Cestari
authors.forename: Magda
authors.initials: M
authors.lastname: Feres
authors.forename: Gustavo Pompermaier
authors.initials: GP
authors.lastname: Garlet
authors.forename: Osny
authors.initials: O
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis; D015342:DNA Probes; D004368:Dry Socket / Q000382:microbiology / Q000473:pathology*; D008297:Male; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014081:Tooth Extraction / Q000009:adverse effects*; D020390:Tooth Socket / Q000382:microbiology / Q000473:pathology*; D014945:Wound Healing
chemical_list: D015342:DNA Probes; D002097:C-Reactive Protein