title: Remodeling and repair of orthopedic tissue: role of mechanical loading and biologics.
abstract: Orthopedic tissues respond to mechanical loads to maintain normal homeostasis and in response to injury. As the body of work on this continues to grow, it is important to synthesize the recent studies across tissues and specialties with one another and with past studies. Hence, this review highlights the knowledge gained since 2000, with only few exceptions, concerning the effects of mechanical load and biologics on remodeling and repair of orthopedic tissue.
authors.affiliation: McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, and Bioengineering Department, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, USA.
authors.forename: Spencer E
authors.initials: SE
authors.lastname: Szczesny
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Lee
authors.forename: Louis J
authors.initials: LJ
authors.lastname: Soslowsky
mesh_terms: D001688:Biological Products / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000502:physiology; D002358:Cartilage, Articular / Q000033:anatomy & histology / Q000293:injuries / Q000502:physiology; D017102:Fracture Healing / Q000187:drug effects* / Q000502:physiology; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008023:Ligaments, Articular / Q000033:anatomy & histology / Q000293:injuries / Q000502:physiology; D008592:Menisci, Tibial / Q000033:anatomy & histology / Q000502:physiology; D013314:Stress, Mechanical; D013708:Tendon Injuries / Q000188:drug therapy / Q000503:physiopathology; D013710:Tendons / Q000033:anatomy & histology / Q000502:physiology; D000070600:Tibial Meniscus Injuries; D016474:Weight-Bearing
chemical_list: D001688:Biological Products