title: Differential conditioned fear response predicts duloxetine treatment outcome in male veterans with PTSD: a pilot study.
abstract: This pilot study tested whether posttraumatic stress disorder (PTSD) patients with impaired conditioned fear acquisition were refractory to open-label duloxetine treatment. Patients with a differential conditioned fear response at pre-treatment subsequently demonstrated significant reductions in PTSD symptoms. These data provide initial evidence of a putative biomarker of selective treatment response in PTSD.
authors.affiliation: Department of Psychiatry, Yale University, 300 George Street, New Haven, CT 06511, USA. deane.aikins@yale.edu
authors.forename: Deane E
authors.initials: DE
authors.lastname: Aikins
authors.forename: Eric D
authors.initials: ED
authors.lastname: Jackson
authors.forename: Alicia
authors.initials: A
authors.lastname: Christensen
authors.forename: Espen
authors.initials: E
authors.lastname: Walderhaug
authors.forename: Sonia
authors.initials: S
authors.lastname: Afroz
authors.forename: Alexander
authors.initials: A
authors.lastname: Neumeister
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003213:Conditioning, Psychological; D000068736:Duloxetine Hydrochloride; D005239:Fear; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010865:Pilot Projects; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D013876:Thiophenes / Q000627:therapeutic use*; D014728:Veterans
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride