title: Partial characterization of cobalamin deficiency in Chinese Shar Peis.
abstract: A total of 22,462 serum sample results from dogs being evaluated for gastrointestinal disease at the Gastrointestinal Laboratory, College of Veterinary Medicine, Texas A&M University were evaluated retrospectively. The proportion of dogs with serum cobalamin concentrations below the reference interval and median serum concentrations were compared between Shar Peis and other dog breeds. Serum samples were also obtained prospectively from 22 healthy and 32 Shar Peis with chronic gastrointestinal disease and 59 healthy dogs of other breeds, and serum concentrations of cobalamin, folate, and methylmalonic acid were determined and compared. Overall, 64.0% (89/139) of serum samples from Shar Peis showed serum cobalamin concentrations below the limit of the reference interval and 38.1% (53/139) of these were below the detectable limit for the assay. The median serum cobalamin concentration in Shar Peis was significantly lower than in other breeds. Shar Peis with gastrointestinal disease had significantly lower serum cobalamin and higher serum methylmalonic acid concentrations compared to healthy Shar Peis. Healthy Shar Peis had significantly increased serum methylmalonic acid concentrations compared to healthy dogs of other breeds. There were no meaningful differences in folate concentrations between groups. In conclusion, Shar Peis have a high prevalence of cobalamin deficiency compared to other breeds and healthy Shar Peis may have subclinical cobalamin deficiency.
authors.affiliation: Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474, USA. mbishop@cvm.tamu.edu
authors.forename: Micah A
authors.initials: MA
authors.lastname: Bishop
authors.forename: Panagiotis G
authors.initials: PG
authors.lastname: Xenoulis
authors.forename: Nora
authors.initials: N
authors.lastname: Berghoff
authors.forename: Niels
authors.initials: N
authors.lastname: Grützner
authors.forename: Jan S
authors.initials: JS
authors.lastname: Suchodolski
authors.forename: Jörg M
authors.initials: JM
authors.lastname: Steiner
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000453:epidemiology*; D004285:Dogs; D005260:Female; D008297:Male; D010375:Pedigree; D015995:Prevalence; D013781:Texas / Q000453:epidemiology; D014805:Vitamin B 12 / Q000097:blood; D014806:Vitamin B 12 Deficiency / Q000453:epidemiology / Q000662:veterinary*
chemical_list: D014805:Vitamin B 12