title: Notch-ing from T-cell to B-cell lymphoid malignancies.
abstract: Notch receptors are transmembrane proteins critically determining cell fate and maintenance of progenitor cells in many developmental systems. Notch signaling is involved in stem cell self-renewal and regulates the main functions of cell life at different levels of development: cell proliferation, differentiation and apoptosis. By virtue of its involvement in the regulation of cell physiology, it is not surprising that a deregulation of the Notch pathway leads to the development of different tumors. In this review, we critically discuss the latest findings concerning Notch roles in hematologic oncology, with a special focus on T-cell acute lymphoblastic leukemia and B-cell malignancies. We also describe the molecular mediators of Notch-driven oncogenic effects and the current pharmacological approaches targeting Notch signaling.
authors.affiliation: Department of Medicine, Surgery and Dentistry, Università degli Studi di Milano, Milan, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Mirandola
authors.forename: Paola
authors.initials: P
authors.lastname: Comi
authors.forename: Everardo
authors.initials: E
authors.lastname: Cobos
authors.forename: W Martin
authors.initials: WM
authors.lastname: Kast
authors.forename: Maurizio
authors.initials: M
authors.lastname: Chiriva-Internati
authors.forename: Raffaella
authors.initials: R
authors.lastname: Chiaramonte
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D019337:Hematologic Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000378:metabolism / Q000473:pathology; D009101:Multiple Myeloma / Q000378:metabolism / Q000473:pathology; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism / Q000473:pathology; D051880:Receptors, Notch / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology; D013601:T-Lymphocytes / Q000378:metabolism* / Q000473:pathology
chemical_list: D051880:Receptors, Notch