title: Transcription factor networks in erythroid cell and megakaryocyte development.
abstract: Erythroid cells and megakaryocytes are derived from a common precursor, the megakaryocyte-erythroid progenitor. Although these 2 closely related hematopoietic cell types share many transcription factors, there are several key differences in their regulatory networks that lead to differential gene expression downstream of the megakaryocyte-erythroid progenitor. With the advent of next-generation sequencing and our ability to precisely define transcription factor chromatin occupancy in vivo on a global scale, we are much closer to understanding how these 2 lineages are specified and in general how transcription factor complexes govern hematopoiesis.
authors.affiliation: Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Louis C
authors.initials: LC
authors.lastname: Doré
authors.forename: John D
authors.initials: JD
authors.lastname: Crispino
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D019070:Cell Lineage / Q000235:genetics / Q000502:physiology; D041905:Erythroid Cells / Q000378:metabolism; D053263:Gene Regulatory Networks / Q000502:physiology*; D006410:Hematopoiesis / Q000235:genetics* / Q000502:physiology; D006801:Humans; D055015:Megakaryocyte-Erythroid Progenitor Cells / Q000378:metabolism / Q000502:physiology*; D008533:Megakaryocytes / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism / Q000502:physiology
chemical_list: D014157:Transcription Factors