title: The SecY complex: conducting the orchestra of protein translocation.
abstract: Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous protein-conducting pathway by which thousands of newly synthesized polypeptides make their way through the lipid bilayer. The channel is not a simple passive pore, however; it displays remarkable complexity by interacting with numerous soluble partners, including SecA, Syd, FtsY and the ribosome in bacteria. For several decades, scientists have been fascinated by the sophistication and versatility of this transport channel. In this review, we cover the current state of the field including some of the newest and most exciting findings on channel structure and mechanism of action.
authors.affiliation: Life Sciences Institute, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, Canada.
authors.forename: Kush
authors.initials: K
authors.lastname: Dalal
authors.forename: Franck
authors.initials: F
authors.lastname: Duong
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D012269:Ribosomal Proteins / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism; D000069816:SEC Translocation Channels; D012440:Saccharomyces / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D000081416:SecA Proteins; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; C087406:FtsY protein, Bacteria; D026901:Membrane Transport Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D012269:Ribosomal Proteins; D000069816:SEC Translocation Channels; C499383:SEC61 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins