title: Intact internal dynamics of the neocortex in acutely paralyzed mice.
abstract: Animals collect sensory information through self-generated movements. Muscle movements drive active feedback of sensory information and determine large parts of the sensory inputs the animal receives; however, little is known about how this active feedback process modulates the ongoing dynamics of the brain. We made electrophysiological recordings from layer 2/3 neurons of the mouse neocortex and compared spontaneous cortical activity in local field potentials and intracellular potential fluctuations between normal and hypomyotonic conditions. We found that pancuronium-induced paralysis did not affect the electrophysiological properties of ongoing cortical activity and its perturbation evoked by visual and tactile stimuli. Thus, internal cortical dynamics are not much affected by active muscle movements, at least, in an acute phase.
authors.affiliation: Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.
authors.forename: Genki
authors.initials: G
authors.lastname: Minamisawa
authors.forename: Kenta
authors.initials: K
authors.lastname: Funayama
authors.forename: Norio
authors.initials: N
authors.lastname: Matsuki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ikegaya
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D055724:Electrophysiological Phenomena / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008813:Mice, Inbred ICR; D019579:Neocortex / Q000187:drug effects / Q000502:physiology*; D010197:Pancuronium / Q000494:pharmacology; D010243:Paralysis / Q000139:chemically induced* / Q000503:physiopathology*; D018408:Patch-Clamp Techniques; D010775:Photic Stimulation; D014110:Touch / Q000187:drug effects / Q000502:physiology
chemical_list: D000777:Anesthetics; D010197:Pancuronium