title: Acute liver failure: an uncommon complication of commonly used medication.
abstract: The incidence of drug-related acute liver failure is approximately 14 per 100,000 populations. Drug-induced liver injury may take place through a variety of mechanism. Withdrawal of the offending agent may result in complete recovery. Clindamycin is known to cause mild derangement of liver function; however, acute liver injury causing severe derangement of liver function associated with encephalopathy is uncommon.
authors.affiliation: 1Internal Medicine Department, University of Toledo Medical Center, Toledo, OH; 2King Abdul Aziz Medical Center, Riyadh, KSA; and 3Gastroenterology and Hepatology Department, University of Toledo Medical Center, Toledo, OH.
authors.forename: Muhammad Z
authors.initials: MZ
authors.lastname: Bawany
authors.forename: Burhan
authors.initials: B
authors.lastname: Bhutto
authors.forename: Wael I
authors.initials: WI
authors.lastname: Youssef
authors.forename: Ali
authors.initials: A
authors.lastname: Nawras
authors.forename: Thomas
authors.initials: T
authors.lastname: Sodeman
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology*; D002981:Clindamycin / Q000009:adverse effects*; D060825:Cognitive Dysfunction / Q000453:epidemiology*; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced*; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin