title: Polled Intersex Syndrome with urethral atresia in a goat.
abstract: A 5-day-old hornless goat was referred with dysuria since birth. The scrotum was absent, and a small penis-like structure was seen below the perineal raphe. On the laparotomy, the testicles were found near the inguinal ring- and attached to a uterus-like structure. On histological analysis, the uterus-like structure was blind-end. Germ cells were absent in the testis. The karyotype of this goat was 60, XX and the SRY gene was absent. The goat was homozygous for a DNA deletion responsible for the Polled Intersex Syndrome (PIS). To the authors' knowledge, this is the first report as the clinical case of the PIS-/- goat with urethral atresia.
authors.affiliation: Department of Veterinary Internal Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Yokota
authors.forename: Aya
authors.initials: A
authors.lastname: Matsuu
authors.forename: Takehito
authors.initials: T
authors.lastname: Morita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuka
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Hishinuma
authors.forename: Saburo
authors.initials: S
authors.lastname: Minami
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hikasa
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics / Q000662:veterinary*; D000818:Animals; D012734:Disorders of Sex Development / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*; D024282:Genes, sry / Q000235:genetics; D015511:Goat Diseases / Q000175:diagnosis* / Q000235:genetics; D006041:Goats; D059785:Karyotype; D013577:Syndrome; D014521:Urethra / Q000002:abnormalities*