title: PTPMT1: connecting cardiolipin biosynthesis to mitochondrial function.
abstract: Cardiolipin, a phospholipid component of the inner mitochondrial membrane, is required for mitochondrial metabolism. In this issue, Zhang et al. (2011) highlight a critical role for PTPMT1, a mitochondrial phosphatase, in cardiolipin biogenesis and possibly in cardiolipin deficiency diseases. Their findings also unveil a yet uncharacterized pathway affecting cell growth.
authors.affiliation: Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
authors.forename: Karim
authors.initials: K
authors.lastname: El-Kouhen
authors.forename: Michel L
authors.initials: ML
authors.lastname: Tremblay