title: A pilot assessment of oxidative stress byproducts and antioxidant activities among Indian patients with various stages of hypertension.
abstract: In humans, hypertension is considered a state of oxidative stress that can contribute to the development of atherosclerosis and other hypertension-induced organ damages. The objective of this study was to evaluate oxidative status, antioxidant activities, and oxidative stress by-products among Indian patients with various stages of hypertension. Lipid profile, enzymatic and non-enzymatic antioxidants, lipid peroxidation as thiobarbituric acid reactive substances (TBARS), C-reactive protein, electrolytes, and minerals were analyzed in the blood of newly diagnosed prehypertensives, stage I and II hypertensives (n = 20 in each group) and were compared to their age-matched normotensives. Elevated levels of lipid profile (except high density lipoprotein cholesterol [HDL-C]) were observed in stage I and II hypertensive patients. Enzymatic and non-enzymatic antioxidants were significantly (P < 0.05) lower, while TBARS and C-reactive protein were higher in prehypertensives, and stage I and II hypertensives. Significant (P <0.05) changes were also observed in the plasma Na(+) and K(+) concentrations among the hypertensive groups. Serum levels of zinc, copper, and magnesium were significantly (P < 0.05) lower in prehypertensives, and stage I and II hypertensives as compared to normotensives. The study indicated a strong association between blood pressure (BP) and oxidative stress-related parameters and suggests a possible role of oxidative stress in the development of elevated BP.
authors.affiliation: Department of Biochemistry, Rabiammal Ahmed Maideen College for Women, Tamilnadu, India.
authors.forename: Raman
authors.initials: R
authors.lastname: Saraswathi
authors.forename: Devarajan
authors.initials: D
authors.lastname: Sankar
authors.forename: Amanat
authors.initials: A
authors.lastname: Ali
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Uehara
authors.forename: Satomi
authors.initials: S
authors.lastname: Abe
authors.forename: Ganapathy
authors.initials: G
authors.lastname: Sambandam
authors.forename: M Ramakrishna
authors.initials: MR
authors.lastname: Rao
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000145:classification / Q000209:etiology*; D007194:India; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010865:Pilot Projects; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D002097:C-Reactive Protein