title: [Study of local anaesthetics--Part 194. Evaluation of carbopol hydrogels with lidocaine].
abstract: The objective of this article is to describe the formulation and evaluation of dermal semisolid drugs--carbopol hydrogels containing the solution of Bukofit, zinc chloride and the local anaesthetic lidocaine. The hydrogels were evaluated after 2, 7, 14 and 28 days after their preparation and stored at the temperature of 5 degrees C +/- 0.2 degrees C. All prepared hydrogels were found to be stable with respect to pH values and rheological parameters. It follows from the found rheological parameters and flow curves that all evaluated hydrogels belong to non-Newtonian thixotropic systems. The extensometric analyses revealed increased deformation values, indicating that the gels can be easily spread out over the mucous membrane which results in the increased ability of the drug to diffuse into it. Based on the results obtained, it can be concluded that the prepared hydrogels have appropriate technological parameters and therefore in the future they may become potential drugs for the treatment of various inflammations in the oral cavity.
authors.affiliation: Univerzita Komenského Bratislava, Farmaceutická fakulta, Katedra galenickej farmácie, Slovenská republika.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Vitková
authors.forename: Petra
authors.initials: P
authors.lastname: Herdová
authors.forename: Jozef
authors.initials: J
authors.lastname: Cizmárik
authors.forename: Marián
authors.initials: M
authors.lastname: Zabka
authors.forename: Bronislava
authors.initials: B
authors.lastname: Brázdovicová
authors.forename: Katarína
authors.initials: K
authors.lastname: Bockajová
mesh_terms: D000180:Acrylic Resins; D000779:Anesthetics, Local; D002626:Chemistry, Pharmaceutical; D002712:Chlorides; D004337:Drug Carriers; D020100:Hydrogels; D008012:Lidocaine; D009092:Mucous Membrane / Q000378:metabolism; D011145:Polyvinyls; D012212:Rheology; D017967:Zinc Compounds
chemical_list: D000180:Acrylic Resins; D000779:Anesthetics, Local; D002712:Chlorides; D004337:Drug Carriers; D020100:Hydrogels; D011145:Polyvinyls; D017967:Zinc Compounds; C006912:carboxypolymethylene; C016837:zinc chloride; D008012:Lidocaine