title: The evolution of angiotensin blockade in the management of cardiovascular disease.
abstract: Dysregulation of the renin-angiotensin system is implicated in many cardiovascular and renal pathologies. Discovery of the renin-angiotensin system represents a major advance in the understanding of hypertension and cardiovascular disease, leading to the development of the anti-angiotensin medications: angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and direct renin inhibitors. Clinical trials have shown that drugs in each of these classes have a protective effect on vascular organs that surpass the protection associated with the lowering of blood pressure alone.
authors.affiliation: Hotel-Dieu de Sorel, 130 St Nicholas, Sorel-Tracy, Québec. nantelp@videotron.ca
authors.forename: Pierre
authors.initials: P
authors.lastname: Nantel
authors.forename: Paul
authors.initials: P
authors.lastname: René de Cotret
mesh_terms: D057911:Angiotensin Receptor Antagonists / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D006801:Humans; D012083:Renin / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology*
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D012083:Renin