title: HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations.
abstract: A study of the human leukocyte antigen (HLA) genetic characteristics in the Zhuang, the largest ethnic population in China, would provide insight into Zhuang history and give a useful tool for disease associations, transplantation, and anthropology. In the present study, we report the comprehensive HLA-A, HLA-B, HLA-C, and HLA-DRB1 alleles and haplotypes in the Zhuang population of southern China for the first time. A total of 13 HLA-A, 24 HLA-B, 22 HLA-C, and 18 HLA-DRB1 were identified in 104 Zhuang individuals. The frequencies of HLA-A*11:01, A*02:07, A*24:02, A*02:03, and A*33:03 on A loci, B*15:02, B*58:01, B*46:01, and B*13:01 on B loci, C*03:04, C*08:01, C*01:02, C*03:02, and C*07:02 on C loci, and DRB1*15:01, DRB1*16:02, DRB1*14:01, DRB1*15:02, and DRB1*03:01 on the DRB1 loci were >10%. The A*33:03-C*03:02-B*58:01-DRB1*03:01 and A*02:07-C*01:02-B*46:01-DRB1*14:01 haplotypes were predominant in the Zhuang. The phylogenetic tree, as well as the analysis of haplotypes, suggested that the Zhuang are genetically similar to southern Chinese populations, especially the Zhuang-Dong language-speaking populations, such as the Bouyei, Dai, and Maonan. Even though the Zhuang and southern Chinese populations shared common alleles and haplotypes, the Zhuang has maintained its unique genetic characteristics.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shi
authors.forename: Xiao-qin
authors.initials: XQ
authors.lastname: Huang
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Yu-fen
authors.initials: YF
authors.lastname: Tao
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Yao
authors.forename: Liang
authors.initials: L
authors.lastname: Yu
authors.forename: Ke-qin
authors.initials: KQ
authors.lastname: Lin
authors.forename: Wen
authors.initials: W
authors.lastname: Yi
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Jia-you
authors.initials: JY
authors.lastname: Chu
mesh_terms: D000483:Alleles; D002681:China / Q000208:ethnology; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D010802:Phylogeny; D011110:Polymorphism, Genetic
chemical_list: D006680:HLA Antigens