title: [Stabilization of cellular membranes as a target of vascular therapy].
abstract: We present data of the study of effect of trimetazidine MB on the state of cellular membranes assessed on lymphocytes as highly sensitive model of hypoxia and endothelial dysfunction. Detection of external cytoplasmatic membrane blebbing and registration of quantity of membrane released microparticles by the method of phase-contrast microscopy were carried out in groups of patients with hypertensive disease without and with ischemic heart disease (IHD). It was found that number of cells in the state of terminal blebbing statistically significantly decreased and number of cells with intact cytoplasmic membrane increased at the background of intake of trimetazidine in all groups of patients. With correlation coefficient 0.76 (p&lt;0.05) between content of membrane microparticles and terminal blebbing lowering of content of membrane released microparticles was noted in peripheral blood of patients of all studied groups. The investigation conducted allows to make conclusion that stabilization of cellular membranes is one of spectra of trimetazidine actions underlying improvement of self feeling of patients with vascular pathology.
authors.forename: A I
authors.initials: AI
authors.lastname: Inzhutova
authors.forename: A A
authors.initials: AA
authors.lastname: Larionov
authors.forename: M M
authors.initials: MM
authors.lastname: Petrova
authors.forename: A B
authors.initials: AB
authors.lastname: Salmina
mesh_terms: D000328:Adult; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D055252:Cell-Derived Microparticles / Q000187:drug effects* / Q000378:metabolism; D057186:Comparative Effectiveness Research; D019610:Cytoprotection; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008858:Microscopy, Phase-Contrast; D008875:Middle Aged; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000378:metabolism; D016896:Treatment Outcome; D014292:Trimetazidine / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D014292:Trimetazidine