title: [The effect of protein metabolism and immunologic function of glutamine after operation in elder gastrointestinal tumor].
abstract: OBJECTIVE
  To explore the effect of protein metabolism and immunologic function of glutamine after operation in elder gastrointestinal tumor.
  
  
  METHODS
  Form march 2007 to 2010, 87 cases of elder gastrointestinal tumor were given parenteral nutrition and glutamine 0.6 g/( Kg x d).The period of treatment were 8 days. IgA, IgG, IgM were CD4, measured by single immunodiffusion, CD3(+), CD4(+), CD8(+), CD4(+) /CD8(+) were measured by immunohistochemical method, and the index(Alb, PAB, TF, nitrogen equilibrium) were monitored the proteid catabolism distribution.
  
  
  RESULTS
  After the treatment, CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+), IgG, IgA, IgM were evidently declined( P <0.05). Alb, PAB, TF were evidently declined in 4 days postoperatively (P < 0.05), the restore were more obvious in 8 days postoperatively (P < 0. 05). Nitrogen equilibrium was worse in the early postoperative and the restore were more obvious in 8 days postoperatively (P < 0.05).
  
  
  CONCLUSIONS
  Glutamine can improve patient's nutrition, enhance their immunologic function.
authors.affiliation: Cadres Ward, Chengdu Military Command General Hospital, Chengdu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Cheng
authors.forename: Yuang
authors.initials: Y
authors.lastname: Lin
authors.forename: Zhi-jie
authors.initials: ZJ
authors.lastname: Huang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xing-guo
authors.initials: XG
authors.lastname: Pan
authors.forename: Hao
authors.initials: H
authors.lastname: Luo
mesh_terms: D000368:Aged; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D017024:Chemotherapy, Adjuvant; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000601:surgery*; D005973:Glutamine / Q000008:administration & dosage*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007074:Immunoglobulin G / Q000378:metabolism*; D007075:Immunoglobulin M / Q000378:metabolism*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D011184:Postoperative Period; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012709:Serum Albumin; D005973:Glutamine