title: A randomized, investigator-blinded, controlled pilot study to evaluate the safety and efficacy of a poly-N-acetyl glucosamine-derived membrane material in patients with venous leg ulcers.
abstract: BACKGROUND
  Standard care for venous leg ulcers (VLUs) has remained unchanged over several decades despite high rates of initial treatment failure and ulcer recurrence.
  
  
  OBJECTIVE
  We sought to evaluate the efficacy, safety, and tolerability of an advanced, poly-N-acetyl glucosamine (pGlcNAc), nanofiber-derived, wound-healing technology among patients with VLUs (Talymed, Marine Polymer Technologies Inc, Danvers, MA).
  
  
  METHODS
  In this randomized, investigator-blinded, parallel-group, controlled study, eligible patients were randomized to treatment with standard care plus pGlcNAc (applied only once, every other week, or every 3 weeks) or to standard care alone. The primary end point was the proportion of patients with complete wound healing at week 20 in the intent-to-treat population (all randomized subjects), with last observation carried forward.
  
  
  RESULTS
  Among 82 randomized patients, 71 completed the study with 7 lost to follow-up and 4 discontinued because of systemic infection. There were no significant group differences with regard to baseline demographic, illness, and VLU characteristics. At 20 weeks, the proportion of patients with completely healed VLUs was 45.0% (n = 9 of 20), 86.4% (n = 19 of 22), and 65.0% (n = 13 of 20) for groups receiving standard care plus pGlcNAc only once, every other week, and every 3 weeks, respectively, versus 45.0% (n = 9 of 20) for those receiving standard care alone (P < .01 for pGlcNAc every other week vs standard care). The novel pGlcNAc advanced wound-healing technology was well tolerated and safe.
  
  
  CONCLUSIONS
  Limitations were small sample size and patients unblinded to treatment allocation.
  
  
  CONCLUSIONS
  These pilot study results suggest that the pGlcNAc advanced wound-healing technology is well tolerated and effective.
authors.affiliation: College of Nursing, Medical University of South Carolina, Charleston, SC 29425-1600, USA. kelechtj@musc.edu
authors.forename: Teresa J
authors.initials: TJ
authors.lastname: Kelechi
authors.forename: Martina
authors.initials: M
authors.lastname: Mueller
authors.forename: Cheryl S
authors.initials: CS
authors.lastname: Hankin
authors.forename: Amy
authors.initials: A
authors.lastname: Bronstone
authors.forename: John
authors.initials: J
authors.lastname: Samies
authors.forename: Phyllis A
authors.initials: PA
authors.lastname: Bonham
mesh_terms: D000117:Acetylglucosamine / Q000494:pharmacology / Q000627:therapeutic use*; D000368:Aged; D005260:Female; D006801:Humans; D057194:Intention to Treat Analysis; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D014647:Varicose Ulcer / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D011134:Polysaccharides; C113831:poly-N-acetyl glucosamine; D000117:Acetylglucosamine