title: The insulin-like growth factor 2 receptor gene Gly1619Arg polymorphism and idiopathic recurrent spontaneous abortion.
abstract: OBJECTIVE
  The insulin-like growth factor 2 (IGF2) and its receptor (IGF2R) are important regulators of placental function and fetal growth. Our aim was to investigate the association between IGF2R gene Gly1619Arg G>A polymorphism and recurrent spontaneous abortion (RSA).
  
  
  METHODS
  Polymerase chain reaction and restriction fragment length polymorphism methods were performed to identify the genotypes in 149 couples with a history of at least three consecutive spontaneous abortions and 149 age-matched, unrelated, and fertile couples.
  
  
  RESULTS
  There were no statistically significant differences in genotype or allele frequency among the couples with RSA and healthy controls.
  
  
  CONCLUSIONS
  We found no evidence that the IGF2R Gly1619Arg variation is associated with RSA.
authors.affiliation: Department of Biology and Medical Genetics, University of Rijeka, Rijeka, Croatia. nina.pereza@xnet.hr
authors.forename: Nina
authors.initials: N
authors.lastname: Pereza
authors.forename: Saša
authors.initials: S
authors.lastname: Ostojić
authors.forename: Marija
authors.initials: M
authors.lastname: Volk
authors.forename: Aleš
authors.initials: A
authors.lastname: Maver
authors.forename: Miljenko
authors.initials: M
authors.lastname: Kapović
authors.forename: Borut
authors.initials: B
authors.lastname: Peterlin
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics / Q000502:physiology; D001120:Arginine / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005998:Glycine / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011247:Pregnancy; D017527:Receptor, IGF Type 2 / Q000235:genetics*; D055815:Young Adult
chemical_list: D017527:Receptor, IGF Type 2; D001120:Arginine; D005998:Glycine