title: Persistence of antibodies in 4-8 year old Austrian children after vaccination with hexavalent DTaP-HBV-IPV/Hib and MMR vaccines.
abstract: To determine the proficiency of the Austrian childhood vaccination schedule to induce long lasting seroprotection against vaccine preventable diseases a seroepidemiological study in 348 children between four and eight years of age was conducted. Antibodies against diphtheria, tetanus, pertussis, hepatitis B, measles, mumps and rubella antigens were assessed in children, who had been vaccinated with hexavalent DTaP-HBV-IPV/Hib vaccines at three, four, five months and in the second year of life and/or MMR vaccines in the second year of life at least once, but mostly twice. High seroprotection rates (SPRs) were detected for tetanus (96%) and measles (90%). SPRs regarding diphtheria and mumps were 81% and 72%, respectively. Rubella-SPRs were 68% in females and 58% in males. Hepatitis B-antibody levels ≥10 mIU/mL were present in 52%; antibodies against pertussis were detected in 27% of the children. SPRs for measles and rubella depended on the interval since last vaccination; mumps-antibodies were significantly lower after one MMR-vaccination only. Antibodies against diphtheria, tetanus and pertussis depended on the interval since last vaccination while HBs-antibodies did not. The low levels of antibodies 1-7 years after vaccination against pertussis, rubella and mumps after only one vaccination should be considered when recommending new vaccination schedules.
authors.affiliation: Department of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, Vienna, Austria.
authors.forename: Maria
authors.initials: M
authors.lastname: Paulke-Korinek
authors.forename: Gustav
authors.initials: G
authors.lastname: Fischmeister
authors.forename: Ana
authors.initials: A
authors.lastname: Grac
authors.forename: Pamela
authors.initials: P
authors.lastname: Rendi-Wagner
authors.forename: Michael
authors.initials: M
authors.lastname: Kundi
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Mohsenzadeh-Rabbani
authors.forename: Katharina
authors.initials: K
authors.lastname: Moritz
authors.forename: Beate
authors.initials: B
authors.lastname: Fenninger
authors.forename: Reinhart
authors.initials: R
authors.lastname: Jarisch
authors.forename: Joanna
authors.initials: J
authors.lastname: Jasinska
authors.forename: Heidemarie
authors.initials: H
authors.lastname: Holzmann
authors.forename: Ursula
authors.initials: U
authors.lastname: Wiedermann
authors.forename: Herwig
authors.initials: H
authors.lastname: Kollaritsch
mesh_terms: D000906:Antibodies / Q000097:blood* / Q000276:immunology; D001317:Austria; D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D008297:Male; D008457:Measles / Q000276:immunology; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000276:immunology*; D009107:Mumps / Q000276:immunology; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage / Q000276:immunology*; D012409:Rubella / Q000276:immunology; D013742:Tetanus / Q000276:immunology; D014611:Vaccination; D017778:Vaccines, Combined; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology; D014917:Whooping Cough / Q000276:immunology
chemical_list: D000906:Antibodies; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D017325:Hepatitis B Vaccines; D022542:Measles-Mumps-Rubella Vaccine; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined; D018074:Vaccines, Conjugate; C541235:diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine