title: [Pleiotropic effects of nicotinic acid therapy in men with coronary heart disease and elevated lipoprotein(a) levels].
abstract: OBJECTIVE
  To assess effects of niacin on risk factors of atherosclerosis in men with coronary heart disease (CHD) and high lipoprotein(a) [Lp(a)] levels.
  
  
  METHODS
  Sixty men (mean age 54+/-6 years) with angiographic evidence of CHD were randomized into two groups. Active group (n=30) received extended release nicotinic acid 1500 mg, control group consisted of remaining 30 patients. All patients received basic therapy with atorvastatin 10-40 mg qd. Blood samples were collected for total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), Lp(a), lipoprotein-associated phospholipase A2 (Lp-PL-2), high-sensitivity C-reactive protein (hsCRP), complex of tissue-type plasminogen activator with plasminogen activator inhibitor type 1 (tPA/PAI-1). Carotid intima media thickness (CIMT) was measured at baseline and after 6-months therapy.
  
  
  RESULTS
  There was no statistically significant difference between the groups in the clinical and biochemical characteristics. During the study lipid profile data were within the target levels. In the active group median percent decrease of Lp(a) level was 23% (from 84+/-40 to 67+/-25 mg/dl after 6 weeks and up to 65+/-37 mg/dl after 6 months of treatment, p<0.01); LDL-C, TG, tPA/PAI-1, and Lp-PL-2 mass levels decreased by 25, 20, 25, and 32%, respectively; HDL-C increased by 16% (p<0.05 vs baseline, respectively). Nicotinic acid treatment produced statistically significant reduction nicotinic acid of the mean CIMT (right: 0.83+/-0.16 vs 0.77+/-0.17 mm, p<0.05; left: 0.88+/-0.21 vs 0.82+/-0.17, p<0.05). In control group no changes of CIMT or blood tests were observed.
  
  
  CONCLUSIONS
  In men with CHD and Lp(a) excess of addition to atorvastatin results in regression of CIMT on an average of 0.06 mm in 6 months. Such rapid and significant effect on the arterial wall structure can be attributed to the complex influence of nicotinic acid on Lp(a), lipids, Lp-PL-2 and thrombogenic factors. This is the first study providing the evidence of using Lp(a) as one of therapeutic targets in patients with high Lp(a) levels for achieving beneficial effect on a surrogate marker of atherosclerosis.
authors.forename: M S
authors.initials: MS
authors.lastname: Safarova
authors.forename: E P
authors.initials: EP
authors.lastname: Trukhacheva
authors.forename: M V
authors.initials: MV
authors.lastname: Ezhov
authors.forename: O I
authors.initials: OI
authors.lastname: Afanas'eva
authors.forename: M I
authors.initials: MI
authors.lastname: Afanas'eva
authors.forename: M I
authors.initials: MI
authors.lastname: Tripoten'
authors.forename: A A
authors.initials: AA
authors.lastname: Liakishev
authors.forename: S N
authors.initials: SN
authors.lastname: Pokrovskiĭ
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood; D050197:Atherosclerosis / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D000069059:Atorvastatin; D002339:Carotid Arteries / Q000187:drug effects / Q000473:pathology; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D004359:Drug Therapy, Combination; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D006951:Hyperlipoproteinemias / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000009:adverse effects; D050356:Lipid Metabolism / Q000187:drug effects*; D017270:Lipoprotein(a) / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000008:administration & dosage / Q000009:adverse effects; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D011758:Pyrroles / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology
chemical_list: D006538:Heptanoic Acids; D000960:Hypolipidemic Agents; D017270:Lipoprotein(a); D017395:Plasminogen Activator Inhibitor 1; D011758:Pyrroles; D009525:Niacin; D000069059:Atorvastatin; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase