title: Effecting skin renewal: a multifaceted approach.
abstract: The skin undergoes intrinsic aging as a normal course, but exposure to ultraviolet (UV) light results in major cumulative damage that manifests as the typical aged photodamaged skin. UV irradiation produces a sequence of changes within the skin layers starting with signaling processes following DNA damage and culminating in nonabsorbed fragmentation of collagen and other proteins within the extracellular matrix. These fragments promote the synthesis of matrix metalloproteinases (MMPs) that further aggravate the damage to the ground substance and add to fragment accumulation. This study describes a unique sequential approach to controlling this photodamage - inhibition of signaling, inhibition of MMPs, proteasome stimulation and mopping up of fragments, stimulation of procollagen and collagen production, and uniform packaging of new collagen fibers. Thus, a multifaceted approach is introduced with presentation of a unique product formulation based on these research principles.
authors.affiliation: Department of Plastic Surgery, University of the Witwatersrand, Johannesburg, South Africa. awidgerow@adarscience.co
authors.forename: Alan D
authors.initials: AD
authors.lastname: Widgerow
authors.forename: Steven K
authors.initials: SK
authors.lastname: Grekin
mesh_terms: D003094:Collagen / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism / Q000502:physiology; D006801:Humans; D057888:Iridoid Glucosides; D039823:Iridoids; D015603:Keratinocytes / Q000378:metabolism / Q000502:physiology; D019668:Liliaceae; D020782:Matrix Metalloproteinases / Q000378:metabolism; D053978:Pentacyclic Triterpenes / Q000494:pharmacology; D010718:Phosphatidylserines / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D011714:Pyrans / Q000494:pharmacology; D017382:Reactive Oxygen Species; D012060:Rejuvenation; D015398:Signal Transduction / Q000502:physiology; D012867:Skin / Q000378:metabolism / Q000503:physiopathology* / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects / Q000502:physiology*; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D057888:Iridoid Glucosides; D039823:Iridoids; D053978:Pentacyclic Triterpenes; D010718:Phosphatidylserines; D010936:Plant Extracts; D011714:Pyrans; D017382:Reactive Oxygen Species; C002769:oleuropein; D003094:Collagen; C017032:asiatic acid; D020782:Matrix Metalloproteinases