title: Synthesis of functionalized 2-aminohydropyridines and 2-pyridinones via domino reactions of arylamines, methyl propiolate, aromatic aldehydes, and substituted acetonitriles.
abstract: An efficient and practical synthetic method for the functionalized 2-amino hydropyridines and 2-pyridinones was successfully developed via the domino reactions of arylamines, methyl propiolate, aromatic aldehydes and the substituted acetonitriles with triethylamine as base catalyst. Reactions involving malononitrile and cyanoacetamide gave exclusively the 2-aminohydropyridines. On the other hand ethyl cyanoacetate resulted in the 2-pyridinones as main products.
authors.affiliation: College of Chemistry & Chemical Engineering, Yangzhou University, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Er-Yan
authors.initials: EY
authors.lastname: Xia
authors.forename: Chao-Guo
authors.initials: CG
authors.lastname: Yan
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D001547:Benzaldehydes / Q000737:chemistry; D002384:Catalysis; D004095:Dihydropyridines / Q000138:chemical synthesis*; D055808:Drug Discovery; D015394:Molecular Structure; D011422:Propionates / Q000737:chemistry; D011728:Pyridones / Q000138:chemical synthesis*
chemical_list: D000097:Acetonitriles; D000447:Aldehydes; D000588:Amines; D001547:Benzaldehydes; D004095:Dihydropyridines; D011422:Propionates; D011728:Pyridones