title: Assembly of homolinear α(1→2)-linked nonamannoside on ionic liquid support.
abstract: An improved method for the synthesis of large and complex oligosaccharides on ionic liquid (IL) support was developed. A strategy to attach the acceptor on IL using a more stable ether linker was used to prevent undesirable decomposition and side products. A "dissolution-evaporation-precipitation" purification procedure was also developed by combining the advantages of precipitation and solid-liquid extraction to reduce mechanical loss and purification time. This approach was successfully used for the rapid assembly of ionic liquid supported homolinear α(1→2)-linked nonamannoside in 25.2% overall yield within 28.5 h.
authors.affiliation: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, P R China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ma
authors.forename: Sheng
authors.initials: S
authors.lastname: Sun
authors.forename: Xiang-Bao
authors.initials: XB
authors.lastname: Meng
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Shu-Chun
authors.initials: SC
authors.lastname: Li
authors.forename: Zhong-Jun
authors.initials: ZJ
authors.lastname: Li
mesh_terms: D006031:Glycosylation; D052578:Ionic Liquids / Q000737:chemistry*; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D052578:Ionic Liquids; D009844:Oligosaccharides