title: Succinylcholine use in adult anesthesia - A multinational questionnaire survey.
abstract: There are no definitive evidence based standards regarding use of succinylcholine (SCh) for anesthesia induction. However, there is a global trend toward eliminating SCh not only in elective, but also in emergency surgery in adults. The aim of the study was to survey the use of SCh in adult elective and emergency anesthesia practice in several European countries and the United States by questionnaire. One hundred and seventy anesthesiologists out of 201 possible, from six institutions in five countries (Croatia, Bosnia and Herzegovina, Hungary, United Kingdom, and the United States) anonymously completed the questionnaire about their use of SCh. The questionnaire was structured to assess the respondents': frequency of use of SCh in adult surgery (elective and emergency), reasons for use or rejection of SCh, positive and negative attributes of SCh, and observed side effects in their practice. Differences in use were tested using X2-test when appropriate. There was a significant difference in the use of SCh between countries for elective surgery with the lower use in UK and Hungary (chi2=45.8, p <0.001). One hundred and seventeen (69%) use it regularly. In emergency surgery 165 (97%) anesthesiologists use it without any significant difference among countries (chi2=2.13, p<0.711). The top indications for SCh use were anticipated difficult intubation/ventilation (74%), caesarean section (54%), and obesity and/or hiatus hernia (49%). The top reasons against SCh use were adequate substitutes (87%), fear of arrhythmias (45%), and anaphylaxis (19%). The most desirable reported drug features were: rapid onset (88%), short duration (64%), and effective relaxation (61%). Forty-six per cent of the surveyed anesthesiologists stated they had never experienced a complication with its use. The most frequently reported side effects were myalgias (47%), bradycardias (42%), and prolonged blockade (39%). Allergic reactions were reported by 13%, and asystole by 12% of physicians. From our survey it is possible to conclude that succinylcholine is still regularly used, at least by surveyed anesthesiologists in Europe and USA, in adult anesthesia practice, especially in elective surgery for which it may be least suited. This reflects the discrepancies between the international guidelines for the use of SCh and the clinical practice of many anesthesiologists in different countries. The regional differences in SCh usage may be considered through anesthesia cultures and practice variations depending on country.
authors.affiliation: University of Split, Split University Hospital Center, Department of Anesthesiology and Intensive Care Medicine, Split, Croatia.
authors.forename: Nenad
authors.initials: N
authors.lastname: Karanović
authors.forename: Mladen
authors.initials: M
authors.lastname: Carev
authors.forename: Goran
authors.initials: G
authors.lastname: Kardum
authors.forename: Nikac
authors.initials: N
authors.lastname: Tomanović
authors.forename: Eckehard
authors.initials: E
authors.lastname: Stuth
authors.forename: Janos
authors.initials: J
authors.lastname: Gal
authors.forename: Mislav
authors.initials: M
authors.lastname: Tonković-Capin
authors.forename: Varja
authors.initials: V
authors.lastname: Dogas
authors.forename: Goran
authors.initials: G
authors.lastname: Racić
authors.forename: Zoran
authors.initials: Z
authors.lastname: Dogas
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000379:methods*; D000777:Anesthetics / Q000008:administration & dosage*; D005061:Europe, Eastern; D005260:Female; D006801:Humans; D008297:Male; D009467:Neuromuscular Depolarizing Agents / Q000008:administration & dosage*; D013390:Succinylcholine / Q000008:administration & dosage*; D011795:Surveys and Questionnaires; D006113:United Kingdom; D014481:United States
chemical_list: D000777:Anesthetics; D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine