title: The pharmacokinetics and metabolism of meloxicam in camels after intravenous administration.
abstract: The pharmacokinetics and metabolism of meloxicam was studied in camels (Camelus dromedarus) (n = 6) following intravenous (i.v.) administration of a dose of 0.6 mg·kg/body weight. The results obtained (mean ± SD) were as follows: the terminal elimination half-life (t(1/2β) ) was 40.2 ± 16.8 h and total body clearance (Cl(T) ) was 1.94 ± 0.66 mL·kg/h. The volume of distribution at steady state (V(SS)) was 92.8 ± 13.7 mL/kg. One metabolite of meloxicam was tentatively identified as methylhydroxy meloxicam. Meloxicam and metabolite were excreted unconjugated in urine. Meloxicam could be detected in plasma 10 days following i.v. administration in camels using a sensitive liquid chromatography tandem mass spectrometry (LC/MS/MS) method.
authors.affiliation: Camel Racing Laboratory, Forensic Evidence Department, Abu Dhabi, United Arab Emirates. iawasfi@live.com
authors.forename: I A
authors.initials: IA
authors.lastname: Wasfi
authors.forename: W A
authors.initials: WA
authors.lastname: Al Ali
authors.forename: B A
authors.initials: BA
authors.lastname: Agha
authors.forename: A M
authors.initials: AM
authors.lastname: Kamel
authors.forename: N A
authors.initials: NA
authors.lastname: Al Biriki
authors.forename: K M
authors.initials: KM
authors.lastname: Al Neaimi
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine; D019540:Area Under Curve; D002162:Camelus / Q000097:blood* / Q000652:urine; D002853:Chromatography, Liquid / Q000662:veterinary; D004350:Drug Residues; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D000077239:Meloxicam; D053719:Tandem Mass Spectrometry / Q000662:veterinary; D013843:Thiazines / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine; D013844:Thiazoles / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam