title: Effects of APOE, APOB and LDLR variants on serum lipids and lack of association with xanthelasma in individuals from Southeastern Brazil.
abstract: Xanthelasma might be a clinical manifestation of dyslipidemia, a recognized risk factor for coronary artery disease. We investigated the association of apolipoprotein E (APOE HhaI), apolipoprotein B (APOB XbaI and Ins/Del) and LDL receptor (LDLR AvaII and HincII) gene polymorphisms with lipid profiles in 100 Brazilians with xanthelasma and 100 controls. Allele frequencies were similar in both groups. APOE, APOB and LDLR genotypes were not correlated with differences in the serum lipid profile. In individuals with xanthelasma, the APOB D allele was associated with less chance of having increased LDL-cholesterol (O.R. = 0.16, CI95% = 0.03-0.94, p = 0.042). In the control group, the APOB X+ allele was associated with less chance of having both increased total cholesterol (O.R. = 0.16, CI95% = 0.03-0.78, p = 0.023) and increased LDL-cholesterol (O.R. = 0.10, CI95% = 0.02-0.60, p = 0.012). Moreover, there was a significantly higher frequency of control individuals (68%) with elevated serum triglyceride levels, compared to patients (48%, p = 0.008). On the other hand, triglyceride levels in controls also seemed to be influenced by all other gene polymorphisms studied, an effect that might be enhanced by environmental factors.
authors.affiliation: Departamento de Biologia Molecular, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP Brazil.
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Nakazone
authors.forename: Miguel A
authors.initials: MA
authors.lastname: De Marchi
authors.forename: Marcela A S
authors.initials: MA
authors.lastname: Pinhel
authors.forename: Carolina F D C
authors.initials: CF
authors.lastname: Barros
authors.forename: Maysa A F
authors.initials: MA
authors.lastname: Júlio
authors.forename: Anielli
authors.initials: A
authors.lastname: Pinheiro
authors.forename: Simone S
authors.initials: SS
authors.lastname: Arazi
authors.forename: Júlia K
authors.initials: JK
authors.lastname: Hotta
authors.forename: Mário H
authors.initials: MH
authors.lastname: Hirata
authors.forename: Rosario D C
authors.initials: RD
authors.lastname: Hirata
authors.forename: José E
authors.initials: JE
authors.lastname: Dos Santos
authors.forename: Dorotéia R S
authors.initials: DR
authors.lastname: Souza