title: One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines.
abstract: The Au(III)-catalyzed cyclization of 2-alkynylanilines was combined in a one-pot procedure with the Au(I)-catalyzed C3-selective direct alkynylation of indoles using the benziodoxolone reagent TIPS-EBX to give a mild, easy and straightforward entry to 2-substituted-3-alkynylindoles. The reaction can be applied to unprotected anilines, was tolerant to functional groups and easy to carry out (RT, and requires neither an inert atmosphere nor special solvents).
authors.affiliation: Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC LCSO, BCH4306, 1015 Lausanne, Switzerland.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Brand
authors.forename: Clara
authors.initials: C
authors.lastname: Chevalley
authors.forename: Jérôme
authors.initials: J
authors.lastname: Waser