title: FDG PET/CT in a patient with spontaneous remission of methotrexate-associated lymphoproliferative disorders after interruption of methotrexate.
abstract: We report a case that fluorodeoxyglucose positron emission tomography (FDG PET)/computed tomography (CT) depicted systemically multiple lesions of methotrexate (MTX)-associated lymphoproliferative disorders. A 70-year-old man receiving MTX for rheumatoid arthritis complained of neck swelling. FDG PET/CT revealed multiple FDG-avid lesions in lymph nodes, lungs, bones, and muscles. Lesions in bones and muscles were not detected on X-CT. Final diagnosis of cervical node was confirmed as MTX-associated lymphoproliferative disorders. FDG PET/CT performed 148 days after discontinuing MTX demonstrated complete remission.
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan. rinnosuke1007@hotmail.com
authors.forename: Rinnosuke
authors.initials: R
authors.lastname: Kuramoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Hirata
authors.forename: Toshiki
authors.initials: T
authors.lastname: Takei
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Oridate
authors.forename: Seigo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Yamada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Imamura
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D000368:Aged; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D049268:Positron-Emission Tomography; D012075:Remission, Spontaneous; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18; D008727:Methotrexate