title: [PD-1/PD-L1 expressions in liver tissues of patients with chronic HBV infection].
abstract: OBJECTIVE
  To detect and compare the PD-1/PD-L1 (programmed death 1/programmed death 1 ligand) expressions in the liver tissues of chronic HBV infection patients in immune tolerant phase and those in immune clearance phase.
  
  
  METHODS
  Liver biopsy samples were divided into two groups: 25 samples from patients in immune clearance phase and 19 samples from patients in immune tolerant phase. PD-1/PD-L1 expressions on T lymphocytes in these liver biopsy specimens were detected by immunohistochemistry method. Percentage of PD-1/PD-L1 positive cells among CD3 positive cells was calculated by semi-quantitative evaluation. Differences between the two groups were statistically analyzed.
  
  
  RESULTS
  PD-1/PD-L1 expressions were significantly higher in the patients in immune tolerant phase as compared to that in immune active phase (P < 0.05). No statistical difference found between the two groups for PD-L1 expression in Kupffer cells (P > 0.05).
  
  
  CONCLUSIONS
  PD-1/PD-L1 expression level can reflect the immune functions of chronic hepatitis B patients.
authors.affiliation: Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Xiao-ying
authors.initials: XY
authors.lastname: Teng
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Xin-gang
authors.initials: XG
authors.lastname: Zhou
authors.forename: Bing
authors.initials: B
authors.lastname: Shen
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.forename: Zhen-wei
authors.initials: ZW
authors.lastname: Lang
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D060890:B7-H1 Antigen / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D005260:Female; D019694:Hepatitis B, Chronic / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D060890:B7-H1 Antigen; C423236:CD274 protein, human; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor