title: Celiac disease and gyneco-obstetrics complications: can serum antibodies modulate tissue transglutaminase functions and contribute to clinical pattern?
abstract: OBJECTIVE
  Untreated celiac disease (CD) is often associated with early miscarriages, infertility, and alterations in menstrual cycle. Tissue transglutaminase (tTG) antibodies could be involved by interfering with tTG transamidating activity and/or biological functions mediated by its interaction with fibronectin (FN).
  
  
  METHODS
  The correlation between the presence of extra-digestive disorders and the reactivity of sera against tTG-FN and its effects on tTG transamidating activity was analyzed in a group or 50 women with recently diagnosed CD.
  
  
  RESULTS
  Heterogeneous behavior was observed among serum samples derived from patients with different complaints, suggesting that differences in fine specificity patterns could condition clinical outcome. Sera from women with gynecological and/or obstetric problems induced significant inhibition of in vitro enzymatic activity in comparison with those without these kinds of disorders.
  
  
  CONCLUSIONS
  The significant correlation observed between serum effects and clinical profile suggests a putative involvement of tTG-specific antibodies in gynecological and/or obstetric disorders during active CD.
authors.affiliation: Cátedra de Inmunología, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Sóñora
authors.forename: Florencia
authors.initials: F
authors.lastname: Muñoz
authors.forename: Natalia
authors.initials: N
authors.lastname: Del Río
authors.forename: Giséle
authors.initials: G
authors.lastname: Acosta
authors.forename: Cecilia
authors.initials: C
authors.lastname: Montenegro
authors.forename: Elena
authors.initials: E
authors.lastname: Trucco
authors.forename: Ana
authors.initials: A
authors.lastname: Hernández
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D015551:Autoimmunity; D002446:Celiac Disease / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005260:Female; D052776:Female Urogenital Diseases / Q000276:immunology / Q000503:physiopathology*; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology / Q000503:physiopathology*; D011503:Transglutaminases / Q000276:immunology / Q000378:metabolism*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D005353:Fibronectins; D011503:Transglutaminases