title: IGF-I and visfatin levels in retinopathy of prematurity.
abstract: OBJECTIVE
  The authors hypothesized that circulating visfatin concentrations in preterm infants might be linked with retinopathy of prematurity (ROP)-like insulin-like growth factor I (IGF-I) levels.
  
  
  METHODS
  The study group comprised 88 children born with a gestational age younger than 32 weeks between 2007 and 2009 who were screened and/or treated for ROP. The authors collected fetal cord blood (sample 1) and a blood sample at 4 to 6 weeks postnatal age (sample 2) for laboratory investigations.
  
  
  RESULTS
  The non-ROP group had higher visfatin-1, visfatin-2, insulin-1, insulin-2, (IGF-I)-1, and (IGF-I)-2 levels than the ROP group (P < .001 for all levels). Change in visfatin was positively correlated with change in IGF-I and change in insulin (P < .001 and P < .001, respectively). Change in IGF-I was positively correlated with change in insulin (P < .001).
  
  
  CONCLUSIONS
  Similar to IGF-I levels, determination of visfatin levels can be a predictive marker of ROP, but more studies are needed.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey. ferhat_cocuk@hotmail.com
authors.forename: Ferhat
authors.initials: F
authors.lastname: Cekmez
authors.forename: Fuat Emre
authors.initials: FE
authors.lastname: Canpolat
authors.forename: Merih
authors.initials: M
authors.lastname: Çetinkaya
authors.forename: Ozgur
authors.initials: O
authors.lastname: Pirgon
authors.forename: Secil
authors.initials: S
authors.lastname: Aydinoz
authors.forename: O Melih
authors.initials: OM
authors.lastname: Ceylan
authors.forename: O Metin
authors.initials: OM
authors.lastname: Ipcioglu
authors.forename: Serdar Umit
authors.initials: SU
authors.lastname: Sarici
mesh_terms: D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D005312:Fetal Blood; D005865:Gestational Age; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008163:Luminescent Measurements; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011863:Radioimmunoassay; D012178:Retinopathy of Prematurity / Q000097:blood*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human