title: Head and neck cancer in young adults and nonsmokers: study of cancer susceptibility by genome-wide high-density SNP microarray mapping.
abstract: CONCLUSIONS
  Our results raise the question as to whether specific patterns of 'germline loss of heterozygosity (LOH)' could contribute to the genetic susceptibility for head and neck squamous cell carcinoma (HNSCC).
  
  
  OBJECTIVE
  HNSCC usually occurs in older individuals with a history of smoking. However, about 5% of HNSCC patients have never used tobacco or develop this disease at an exceptionally young age. Therefore, genetic susceptibility must contribute significantly to HNSCC risk. The objective was to introduce a novel approach that might help to unveil candidate genes contributing to cancer predisposition and to identify individuals at risk for HNSCC, and to present our observations with this method in a specific group of patients.
  
  
  METHODS
  High-resolution SNP (single-nucleotide polymorphism) microarray mapping for homozygous stretches in germline DNA was performed in 12 patients who appeared particularly susceptible to develop HNSCC, because they were exceptionally young or never users of tobacco.
  
  
  RESULTS
  We could identify strings of consecutive homozygous SNPs that were much longer than would be expected to appear by chance alone, indicating regions of DNA deletions that we named germline LOH.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Freiburg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Pfeiffer
authors.forename: Thorsten
authors.initials: T
authors.lastname: Wiech
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Gerd J
authors.initials: GJ
authors.lastname: Ridder
authors.forename: Roland
authors.initials: R
authors.lastname: Laszig
authors.forename: Ralf
authors.initials: R
authors.lastname: Birkenhäger
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005858:Germany / Q000453:epidemiology; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck