title: Water equivalent path length measurement in proton radiotherapy using time resolved diode dosimetry.
abstract: OBJECTIVE
  To verify water equivalent path length (WEPL) before treatment in proton radiotherapy using time resolved in vivo diode dosimetry.
  
  
  METHODS
  Using a passively scattered range modulated proton beam, the output of a diode driving a fast current-to-voltage amplifier is recorded at a number of depths in a water tank. At each depth, a burst of overlapping single proton pulses is observed. The rms duration of the burst is computed and the resulting data set is fitted with a cubic polynomial.
  
  
  RESULTS
  When the diode is subsequently set to an arbitrary depth and the polynomial is used as a calibration curve, the "unknown" depth is determined within 0.3 mm rms.
  
  
  CONCLUSIONS
  A diode or a diode array, placed (for instance) in the rectum in conjunction with a rectal balloon, can potentially determine the WEPL at that point, just prior to treatment, with submillimeter accuracy, allowing the beam energy to be adjusted. The associated unwanted dose is about 0.2% of a typical single fraction treatment dose.
authors.affiliation: Laboratory for Particle Physics and Cosmology, Harvard University, 18 Hammond Street, Cambridge, Massachusetts 02138, USA. bgottsch@fas.harvard.edu
authors.forename: B
authors.initials: B
authors.lastname: Gottschalk
authors.forename: S
authors.initials: S
authors.lastname: Tang
authors.forename: E H
authors.initials: EH
authors.lastname: Bentefour
authors.forename: E W
authors.initials: EW
authors.lastname: Cascio
authors.forename: D
authors.initials: D
authors.lastname: Prieels
authors.forename: H M
authors.initials: HM
authors.lastname: Lu
mesh_terms: D061766:Proton Therapy; D011874:Radiometry; D011878:Radiotherapy / Q000379:methods*; D013997:Time Factors; D014867:Water
chemical_list: D014867:Water