title: Oxidant/antioxidant balance, minerals status and apoptosis in peripheral blood of dogs naturally infected with Dirofilaria immitis.
abstract: The present study was aimed to examine lipid peroxides, antioxidants, zinc, copper, iron panels and apoptosis in peripheral blood of dogs with clinical dirofilariosis. In comparison to healthy control, erythrocytic lipid peroxides level and superoxide dismutase activity were significantly (P<0.01) higher in diseased dogs. However, level of reduced glutathione and activities of glutathione peroxidase, glutathione-S-transferase and catalase were significantly (P<0.01) lower in diseased dogs. Blood zinc, copper and iron levels in dogs with dirofilariosis were significantly (P<0.01) lower than the healthy control. The percent apoptotic peripheral leukocytes were significantly higher in dogs with dirofilariosis in comparison with healthy control. From the present study, it is concluded that significant alterations in oxidant/antioxidant balance, mineral status and rate of apoptosis in peripheral blood may be implicated in the pathogenesis of clinical canine dirofilariosis.
authors.affiliation: Division of Medicine, Indian Veterinary Research Institute, Izatnagar 243 122, Bareilly, UP, India. udimrimesh@rediffmail.com
authors.forename: Umesh
authors.initials: U
authors.lastname: Dimri
authors.forename: S K
authors.initials: SK
authors.lastname: Singh
authors.forename: M C
authors.initials: MC
authors.lastname: Sharma
authors.forename: S K
authors.initials: SK
authors.lastname: Behera
authors.forename: Dinesh
authors.initials: D
authors.lastname: Kumar
authors.forename: P
authors.initials: P
authors.lastname: Tiwari
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis; D017209:Apoptosis / Q000502:physiology*; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D003300:Copper / Q000097:blood; D004183:Dirofilaria immitis; D004184:Dirofilariasis / Q000097:blood / Q000378:metabolism*; D004283:Dog Diseases / Q000097:blood / Q000378:metabolism / Q000469:parasitology*; D004285:Dogs; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D045792:Norisoprenoids / Q000097:blood; D010084:Oxidation-Reduction; D015032:Zinc / Q000097:blood
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D045792:Norisoprenoids; D003300:Copper; D002374:Catalase; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D005978:Glutathione; D015032:Zinc