title: Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss.
abstract: Leptin has emerged over the past decade as a key hormone not only in energy balance regulation but also in neuroendocrine and inflammatory processes. The aim of the present study was to evaluate whether hyperleptinemia deregulates neuropeptides during weight loss. A total of 86 post-pubertal obese adolescents (with or without hyperleptinemia) participated in one year of interdisciplinary weight loss therapy (clinical, nutritional, psychological and exercise-related). Adipokine and neuropeptide concentrations were measured by ELISA, visceral fat was measured by ultrasound and body composition was measured by pletismography. The hyperleptinemic patients presented a lower alpha-MSH concentration and higher NPY/AgRP ratio while the adiponectin/leptin (A/L) ratio was lower compared with the non-hyperleptinemic group. After therapy, significant improvements in BM, BMI, body fat mass, visceral and subcutaneous fat, HOMA-IR, QUICKI, total cholesterol and triglycerides were observed in both groups. Indeed, we observed significant increases in adiponectin and A/L as well as reductions in leptin and NPY/AgRP ratio in the hyperleptinemic group. In the stepwise multiple linear regression analysis with leptin concentration as the dependent variable, α-MSH and body fat mass (%) were the independent predictors to explain leptin concentration. For the entire group, we found positive correlations between leptinemia and BMI and body fat mass (%) as well as a negative correlation with free fat mass (%) and alpha-MSH. Finally, we verified negative correlations between adiponectin/leptin ratio with total cholesterol and LDL-c, only in hyperleptinemic patients. In conclusion, the hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss.
authors.affiliation: Biosciences Department, Federal University of São Paulo-Paulista Medicine School-UNIFESP-EPM, São Paulo, Brazil. ana.damaso@unifesp.br
authors.forename: Ana R
authors.initials: AR
authors.lastname: Dâmaso
authors.forename: Aline
authors.initials: A
authors.lastname: de Piano
authors.forename: Priscila L
authors.initials: PL
authors.lastname: Sanches
authors.forename: Flávia
authors.initials: F
authors.lastname: Corgosinho
authors.forename: Lian
authors.initials: L
authors.lastname: Tock
authors.forename: Lila M
authors.initials: LM
authors.lastname: Oyama
authors.forename: Luciana
authors.initials: L
authors.lastname: Tock
authors.forename: Claudia M Oller
authors.initials: CM
authors.lastname: do Nascimento
authors.forename: Sérgio
authors.initials: S
authors.lastname: Tufik
authors.forename: Marco Túlio
authors.initials: MT
authors.lastname: de Mello
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D001823:Body Composition; D050218:Body Fat Distribution; D002784:Cholesterol / Q000097:blood; D004038:Diet, Reducing / Q000523:psychology; D015536:Down-Regulation; D005081:Exercise Therapy / Q000379:methods* / Q000523:psychology; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat; D020738:Leptin / Q000502:physiology*; D008297:Male; D009479:Neuropeptides / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000000981:diagnostic imaging / Q000235:genetics / Q000523:psychology / Q000628:therapy; D010991:Plethysmography; D014280:Triglycerides / Q000097:blood; D014463:Ultrasonography; D015854:Up-Regulation; D015431:Weight Loss; D055815:Young Adult; D000521:alpha-MSH / Q000097:blood*
chemical_list: D052242:Adiponectin; D020738:Leptin; D009479:Neuropeptides; D014280:Triglycerides; D000521:alpha-MSH; D002784:Cholesterol