title: Peptidomimetic inhibitors of bacterial peptide deformylase.
abstract: A series of N-formyl hydroxylamine peptide deformylase inhibitors containing a cyclic azaamino acid moiety between the P1' and P3' substituents are presented. Selected compounds display antibacterial activity against pathogens associated with respiratory tract infections with representative compounds showing excellent MICs against Haemophilus influenzae.
authors.affiliation: Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, United Kingdom. stephen.east@evotec.com
authors.forename: Stephen P
authors.initials: SP
authors.lastname: East
authors.forename: Andrew
authors.initials: A
authors.lastname: Ayscough
authors.forename: Ian
authors.initials: I
authors.lastname: Toogood-Johnson
authors.forename: Steven
authors.initials: S
authors.lastname: Taylor
authors.forename: Wayne
authors.initials: W
authors.lastname: Thomas
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003500:Cyclization; D006193:Haemophilus influenzae / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D057786:Peptidomimetics; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D057786:Peptidomimetics; D000581:Amidohydrolases; C084507:peptide deformylase