title: Synthesis and biological evaluation of novel 6, 7-dimethoxy-3-(4-pyridyl)-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-yl-4-substituted phenylmethanone/ethanone derivatives.
abstract: A series of 6,7-dimethoxy-3-(4-pyridyl)-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-yl-4-substituted phenylmethanone/ethanone derivatives were synthesized and in vitro activity against mycobacterium tuberculosis (MTB) and INHR-MTB were carried out. Among the synthesized compounds, compound (4h) 6,7-dimethoxy-3-(4-pyridyl)-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-yl-4-pyridyl methanone was found to be the most active agent against MTB and INHR-MTB with a minimum inhibitory concentration of 0.22 μM.
authors.affiliation: New Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan, India. asraf80med@rediffmail.com
authors.forename: Mohamed Ashraf
authors.initials: MA
authors.lastname: Ali
authors.forename: Rusli
authors.initials: R
authors.lastname: Ismail
authors.forename: Tan Soo
authors.initials: TS
authors.lastname: Choon
authors.forename: Manogaran
authors.initials: M
authors.lastname: Elumalai
authors.forename: Suresh
authors.initials: S
authors.lastname: Kumar
authors.forename: Hasnah
authors.initials: H
authors.lastname: Osman
authors.forename: Jeyabalan
authors.initials: J
authors.lastname: Govidasamy
authors.forename: Rajesh
authors.initials: R
authors.lastname: Yadav
authors.forename: Garima
authors.initials: G
authors.lastname: Yadav
authors.forename: Ravinder
authors.initials: R
authors.lastname: Kour
authors.forename: Swati
authors.initials: S
authors.lastname: Vyas
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007192:Indenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C572404:6,7-dimethoxy-3-(4-pyridyl)-2,3,3a,4-tetrahydroindeno(1,2-c)pyrazol-2-yl-4-pyridyl methanone; D000900:Anti-Bacterial Agents; D007192:Indenes; D011720:Pyrazoles