title: [Association between serum amyloid protein A1 polymorphisms and carotid intima media thickness in Han Chinese].
abstract: OBJECTIVE
  To explore the association between genetic polymorphism of serum amyloid protein A1 (SAA1) with carotid intima media thickness in a healthy Han Chinese population of Xinjiang.
  
  
  METHODS
  A total of 449 healthy Han Chinese participating the cardiovascular risk survey between June 2007 and September 2009 were included, the genotypes of the SAA1 were detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The mean IMT of the right and left common carotid arteries were measured by B-mode ultrasonography.
  
  
  RESULTS
  (1) There was strong linkage disequilibrium between rs12218 and rs2229338 (D' = 0.89). (2) The carotid common IMT (CC-IMT) and the carotid bulb IMT (CB-IMT) were similar between the AA genotype (wild genotype) and the GGFAG genotype (mutational genotype) in rs2229338 of SAA1 gene. (3) CC-IMT [(0.081 ± 0.071) cm vs (0.068 ± 0.019) cm, P = 0.01] was significantly thicker in CC + CT genotype (mutational genotype) group than in TT genotype (wild genotype) of rs12218 group and the difference remains significant after adjustment for age, gender, blood pressure, waist circumference, creatinine and high density lipoprotein cholesterol. CB-IMT [(0.085 ± 0.038) cm vs. (0.081 ± 0.052) cm, P = 0.36] was similar between CC + CT genotype and TT genotype of rs12218 groups.
  
  
  CONCLUSIONS
  Our results suggested that the genetic polymorphism of SAA1 might be linked with IMT and rs12218 mutation could serve as a promoting factor for IMT in Han Chinese people.
authors.affiliation: Heart Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Yi-tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Yi-ning
authors.initials: YN
authors.lastname: Yang
authors.forename: Zhen-yan
authors.initials: ZY
authors.lastname: Fu
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.forename: Ding
authors.initials: D
authors.lastname: Huang
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Bang-dang
authors.initials: BD
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000685:Serum Amyloid A Protein / Q000235:genetics*
chemical_list: C521404:SAA1 protein, human; D000685:Serum Amyloid A Protein