title: Effects of dipotassium trioxohydroxytetrafluorotriborate (K2[BO3F4OH]) on genetic material and inhibition of cell division in human cell cultures.
abstract: We have examined antiproliferative, cytotoxic, and genotoxic potential of a halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate (K₂[B₃O₃F₄OH]). The impact on cell growth was evaluated by alamarBlue assay in basal cell carcinoma culture. Cytostatic, cytotoxic, and genotoxic potential were evaluated in lymphocytes culture, applying cytokinesis-block micronucleus cytome assay and chromosome aberrations analysis. Tested concentrations (0.05, 0.1, 0.2, and 0.4 mg/mL) were correlated with inhibition of cell growth in basal cell carcinoma culture and with the lymphocytes proliferation. Clastogenic activity has been confirmed, without evidences of aneugenic activity, in human lymphocytes.
authors.affiliation: Institute for Genetic Engineering and Biotechnology, University of Sarajevo, Bosnia and Herzegovina. sanin.haveric@ingeb.ba
authors.forename: Sanin
authors.initials: S
authors.lastname: Haveric
authors.forename: Anja
authors.initials: A
authors.lastname: Haveric
authors.forename: Kasim
authors.initials: K
authors.lastname: Bajrovic
authors.forename: Borivoj
authors.initials: B
authors.lastname: Galic
authors.forename: Milka
authors.initials: M
authors.lastname: Maksimovic
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D001896:Boron Compounds / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D015394:Molecular Structure; D009152:Mutagenicity Tests; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D001896:Boron Compounds; C561431:dipotassium trioxohydroxytetrafluorotriborate