title: [Case report: a normal dose of rocuronium achieved the desired effect in a short time after the administration of sugammadex during reoperation].
abstract: A 69-year-old man with normal renal function underwent resection of a parotid tumor under general anesthesia. For tracheal intubation, rocuronium 0.6 mg x kg(-1) was administered, and for facial nerve stimulation, sugammadex 2 mg x kg(-1) was administered immediately after intubation. The operation time was 3 h. At the end of the surgery, sugammadex 2 mg x kg(-1) was administered again. Bleeding occurred 6 h after the surgery. During the second operation, rocuronium 0.6 mg x kg (-1) was administered for tracheal intubation. Maximal suppression was achieved 1 min 42 s after the administration of rocuronium, and the recovery time was 44 min. The times for both maximal suppression and recovery are similar to those when the same dose of rocuronium was used without sugammadex. The half-life of sugammadex is about 2 h. From the observations in this case, we think that after the completion of approximately 3 half-lives, a normal dose of rocuronium can produce the desired effect without the influence of residual sugammadex present in the plasma.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Asahikawa 078-8510.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Sasakawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kurosawa
authors.forename: Chika
authors.initials: C
authors.lastname: Kikuchi
authors.forename: Osamu
authors.initials: O
authors.lastname: Takahata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwasaki
mesh_terms: D000368:Aged; D000732:Androstanols / Q000008:administration & dosage*; D000768:Anesthesia, General; D006207:Half-Life; D006801:Humans; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D010307:Parotid Neoplasms / Q000601:surgery; D012086:Reoperation; D000077123:Rocuronium; D000077122:Sugammadex; D013997:Time Factors; D047408:gamma-Cyclodextrins / Q000008:administration & dosage* / Q000097:blood
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium