title: New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities.
abstract: Four new metabolites, chaetomugilins P-R and 11-epi-chaetomugilin I, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and various chemical transformations. Particularly, the skeleton of chaetomugilin P is different from that of other azaphilones isolated from this fungal strain to date. In addition, these compounds significantly inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan. yamada@gly.oups.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Muroga
authors.forename: Masaaki
authors.initials: M
authors.lastname: Jinno
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kajimoto
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Usami
authors.forename: Atsushi
authors.initials: A
authors.lastname: Numata
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002597:Chaetomium / Q000737:chemistry*; D005399:Fishes / Q000382:microbiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010860:Pigments, Biological / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans; D010860:Pigments, Biological; C494154:azaphilone