title: Imaging stroke patients with unclear onset times.
abstract: Stroke is a leading cause of death and adult morbidity worldwide. By defining stroke symptom onset by the time the patient was last known to be well, many patients whose onsets are unwitnessed are automatically ineligible for thrombolytic therapy. Advanced brain imaging may serve as a substitute witness to estimate stroke onset and duration in those patients who do not have a human witness. This article reviews and compares some of these imaging-based approaches to thrombolysis eligibility, which can potentially expand the use of thrombolytic therapy to a broader population of acute stroke patients.
authors.affiliation: Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, MGH, 149 Thirteenth Street Suite 2301, Charlestown, MA 02129, USA. ona@nmr.mgh.harvard.edu
authors.forename: Ona
authors.initials: O
authors.lastname: Wu
authors.forename: Lee H
authors.initials: LH
authors.lastname: Schwamm
authors.forename: A Gregory
authors.initials: AG
authors.lastname: Sorensen
mesh_terms: D002533:Cerebral Angiography / Q000379:methods*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods*; D020521:Stroke / Q000175:diagnosis*