title: JLK1486, a Bis 8-Hydroxyquinoline-Substituted Benzylamine, Displays Cytostatic Effects in Experimental Gliomas through MyT1 and STAT1 Activation and, to a Lesser Extent, PPARγ Activation.
abstract: Gliomas account for 5% to 7% of all solid cancers in adults and up to 30% of solid cancers in children; glioblastomas are the most malignant type of glioma and often have dismal prognoses. The alkylating agent temozolomide provides the greatest chemotherapeutic benefits currently available; however, glioblastoma patients cannot be cured. Novel drugs that efficiently combat glioblastomas are therefore of great interest. We report here that JLK1486, an 8-hydroxyquinoline-substituted benzylamine, could represent a novel chemical scaffold to reach this goal. Indeed, JLK1486 mediated anticancer activity in vivo (through intravenous as well as oral routes of administrations) in an orthotopic xenograft model and displayed efficiency similar to that of temozolomide. The therapeutic benefits of JLK1486 seem to relate to its ability to activate various transcription factors (including Myt1, STAT1, and peroxisome proliferator-activated receptor γ) in glioma cells. These transcription factors are implicated in the control of glioma cell proliferation, and the resultant global effect of their activation by JLK1486 was cytostatic, not cytotoxic. Thus, the current study opens the door for the development of novel compounds to combat glioblastoma using 8-hydroxyquinoline benzylamine analogs.
authors.affiliation: Laboratoire de Toxicologie, Faculté de Pharmacie; Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Céline
authors.initials: C
authors.lastname: Bruyère
authors.forename: Sébastien
authors.initials: S
authors.lastname: Madonna
authors.forename: Gwendoline
authors.initials: G
authors.lastname: Van Goietsenoven
authors.forename: Véronique
authors.initials: V
authors.lastname: Mathieu
authors.forename: Jean
authors.initials: J
authors.lastname: Dessolin
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Kraus
authors.forename: Florence
authors.initials: F
authors.lastname: Lefranc
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss