title: Anesthetic management of patients undergoing extra-anatomic renal bypass surgery for renovascular hypertension.
abstract: Renal artery disease is the most common cause for surgically curable form of hypertension. In a small subset of patients with severe aortic disease where the aorta is not suitable for endovascular technique and to provide an arterial inflow, an extra-anatomic renal bypass surgery (EARBS) is an option. Anesthetic management of such procedures has not been described so far in the literature. We retrospectively analyzed the anesthetic techniques used in all patients who underwent EARBS between February 1998 and June 2008 at this institute. We also further analyzed data concerning blood pressure (BP) control and renal function response following surgery as outcome variable measures. A total of 11 patients underwent EARBS during this period. Five received oral clonidine with premedication. During laryngoscopy, esmolol was used in 4 patients, while lignocaine was used in remaining 7 patients. Of 11 patients, 7 showed significant hemodynamic response to laryngoscopy and intubation; among these, one had oral clonidine with premedicant, and 6 received lignocaine just before laryngoscopy. Intravenous vasodilators were used to maintain target BP within 20% of baseline during perioperative period. All patients received renal protective measures. During follow-up, 10% were considered cured, 70% had improved BP response, while 20% failed to show improvement in BP response. Renal functions improved in 54.5%, remain unchanged in 36.5%, and worsened in 9% of patients. Use of clonidine during premedication and esmolol before laryngoscopy were beneficial in attenuating hemodynamic response to laryngoscopy, while use of vasodilators to maintain target BP within 20% of baseline, and routine use of renal protective measures appear to be promising in patients undergoing EARBS.
authors.affiliation: Campbellton Regional Hospital, Campbellton, NB, Canada.
authors.forename: Bhupesh
authors.initials: B
authors.lastname: Kumar
authors.forename: Prabhat Kumar
authors.initials: PK
authors.lastname: Sinha
authors.forename: M
authors.initials: M
authors.lastname: Unnikrishnan
mesh_terms: D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure / Q000502:physiology; D003000:Clonidine; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000601:surgery*; D007442:Intubation, Intratracheal / Q000009:adverse effects / Q000379:methods; D007668:Kidney / Q000503:physiopathology / Q000601:surgery*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D011229:Preanesthetic Medication; D011300:Preoperative Care; D011412:Propanolamines / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome; D014563:Urodynamics / Q000502:physiology; D058017:Vascular Grafting; D014656:Vascular Surgical Procedures / Q000401:mortality
chemical_list: D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C036604:esmolol; D003000:Clonidine