title: Diagnosis and treatment difficulties in 18-year-old male patient with hereditary hemochromatosis, chronic hepatitis B, Gilbert syndrome and ulcerative colitis.
abstract: Among possible causes of chronic hepatitis in adolescents most common are infections, autoimmune disorders and metabolic diseases. Thus, diagnostic procedures should be multidirectional. This study reports diagnosis and treatment difficulties in an 18-year-old male patient with hereditary hemochromatosis (HH), ulcerative colitis (UC), chronic hepatitis B (CHB) and Gilbert syndrome. The presented case illustrates problems in diagnostics related to the presence of numerous disease conditions in one patient. It should be taken into consideration that these diseases coexisting in one patient can mutually affect their symptoms creating specific diagnostic difficulties.
authors.affiliation: Departament of Infectious Diseases, Medical University of Gdansk, Gdańsk, Poland. ksikorska@gumed.edu.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Sikorska
authors.forename: Anna
authors.initials: A
authors.lastname: Liberek
authors.forename: Tomasz
authors.initials: T
authors.lastname: Romanowski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Szlagatys-Sidorkiewicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Landowski
authors.forename: Krzysztof P
authors.initials: KP
authors.lastname: Bielawski
mesh_terms: D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D005878:Gilbert Disease / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D014453:Glucuronosyltransferase / Q000235:genetics; D006432:Hemochromatosis / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D000071020:Hemochromatosis Protein; D019694:Hepatitis B, Chronic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D016254:Mutagenesis, Insertional; D009705:Nucleosides / Q000627:therapeutic use; D011110:Polymorphism, Genetic; D016385:TATA Box / Q000235:genetics; D000099148:UGT1A1 Enzyme
chemical_list: D000998:Antiviral Agents; D001379:Azathioprine; D014453:Glucuronosyltransferase; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D007166:Immunosuppressive Agents; D008565:Membrane Proteins; D009705:Nucleosides; D000099148:UGT1A1 Enzyme; C103673:HFE protein, human