title: Salicylate-selective electrode based on a biomimetic guanidinium ionophore.
abstract: A biomimetic strategy was employed in the development of oxoanion-selective ionophores containing the guanidinium functional group. These ionophores mimic the selective interaction observed between arginine residues of proteins and oxoanions. In previous work, it was demonstrated that a structurally rigid guanidinium ionophore exhibited excellent hydrogen sulfite selectivity (Anal. Chem. 1994, 66, 3188-3192). Herein, we describe guanidinium-containing ionophores that are selective for the oxoanion salicylate. The ability to rationally design anion-selective electrodes through this biomimetic strategy, and to both alter selectivity and improve response characteristics through structural changes to the ionophore, has been demonstrated. (1)H-NMR complexation and modeling studies were used to examine and correlate the selectivity observed with the structure of the guanidinium compounds.
authors.affiliation: Department of Chemistry and Center of Membrane Sciences, University of Kentucky, Lexington, Kentucky 40506-0055.
authors.forename: R S
authors.initials: RS
authors.lastname: Hutchins
authors.forename: P
authors.initials: P
authors.lastname: Bansal
authors.forename: P
authors.initials: P
authors.lastname: Molina
authors.forename: M
authors.initials: M
authors.lastname: Alajarín
authors.forename: A
authors.initials: A
authors.lastname: Vidal
authors.forename: L G
authors.initials: LG
authors.lastname: Bachas