title: One-pot tuning of Au nucleation and growth: from nanoclusters to nanoparticles.
abstract: We describe a simple and effective method to obtain colloidal surface-functionalized Au nanoparticles. The method is primarily based on irradiation of a gold solution with high-flux X-rays from a synchrotron source in the presence of 11-mercaptoundecanoic acid (MUA). Extensive tests of the products demonstrated high colloidal density as well as excellent stability, shelf life, and biocompatibility. Specific tests with X-ray diffraction, UV-visible spectrometry, visible microscopy, Fourier transform infrared spectroscopy, dark-field visible-light scattering microscopy, and transmission electron microscopy demonstrated that MUA, being an effective surfactant, not only allows tunable size control of the nanoparticles, but also facilitates functionalization. The nanoparticle sizes were 6.45 ± 1.58, 1.83 ± 1.21, 1.52 ± 0.37 and 1.18 ± 0.26 nm with no MUA and with MUA-to-Au ratios of 1:2, 1:1, and 3:1. The MUA additionally enabled functionalization with l-glycine. We thus demonstrated flexibility in controlling the nanoparticle size over a large range with narrow size distribution.
authors.affiliation: Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan.
authors.forename: Sheng-Feng
authors.initials: SF
authors.lastname: Lai
authors.forename: Wen-Chang
authors.initials: WC
authors.lastname: Chen
authors.forename: Cheng-Liang
authors.initials: CL
authors.lastname: Wang
authors.forename: Hsiang-Hsin
authors.initials: HH
authors.lastname: Chen
authors.forename: Shin-Tai
authors.initials: ST
authors.lastname: Chen
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Chien
authors.forename: Yi-Yun
authors.initials: YY
authors.lastname: Chen
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Hung
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Cai
authors.forename: Enrong
authors.initials: E
authors.lastname: Li
authors.forename: Ivan M
authors.initials: IM
authors.lastname: Kempson
authors.forename: Y
authors.initials: Y
authors.lastname: Hwu
authors.forename: C S
authors.initials: CS
authors.lastname: Yang
authors.forename: Eng-Soon
authors.initials: ES
authors.lastname: Tok
authors.forename: Hui Ru
authors.initials: HR
authors.lastname: Tan
authors.forename: Ming
authors.initials: M
authors.lastname: Lin
authors.forename: G
authors.initials: G
authors.lastname: Margaritondo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003102:Colloids / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000737:chemistry; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D010316:Particle Size; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013499:Surface Properties
chemical_list: C505222:11-mercaptoundecanoic acid; D001672:Biocompatible Materials; D003102:Colloids; D005227:Fatty Acids; D013438:Sulfhydryl Compounds; D006046:Gold