title: Risk of lymph node metastasis in patients with pedunculated type early invasive colorectal cancer: a retrospective multicenter study.
abstract: Depth of invasion in early invasive colorectal cancer is considered an important predictive factor for lymph node metastasis. However, no large-scale reports have established the relationship between invasion depth of pedunculated type early invasive colorectal cancers and risk of lymph node metastasis. The aim of this retrospective cohort study was to clarify the risk of lymph node metastasis in pedunculated type early invasive colorectal cancers in a large series. Patients with pedunculated type early invasive colorectal cancer who underwent endoscopic or surgical resection at seven referral hospitals in Japan were enrolled. Haggitt's line was used as baseline and the invasion depth was classified into two groups, head invasion and stalk invasion. The incidence of lymph node metastasis was investigated between patients with head and stalk invasion. We analyzed 384 pedunculated type early invasive colorectal cancers in 384 patients. There were 154, 156, and 74 endoscopic resection cases, endoscopic resection followed by surgical operation, and surgical resection cases, respectively. There were 240 head invasion and 144 stalk invasion lesions. Among the lesions treated surgically, the overall incidence of lymph node metastasis was 3.5% (8/230). The incidence of lymph node metastasis was 0.0% (0/101) in patients with head invasion, as compared with 6.2% (8/129) in patients with stalk invasion. Pedunculated type early invasive colorectal cancers pathologically diagnosed as head invasion can be managed by endoscopic treatment alone.
authors.affiliation: Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan. tamatsud@ncc.go.jp
authors.forename: Takahisa
authors.initials: T
authors.lastname: Matsuda
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Fukuzawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Uraoka
authors.forename: Masataka
authors.initials: M
authors.lastname: Nishi
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Nozomu
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ikematsu
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujii
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Murakami
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Shimoda
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kushima
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujimori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012008:Recurrence; D012189:Retrospective Studies; D012306:Risk