title: Do CD4+ Foxp3+ Treg cells correlate with transplant outcomes: a systematic review on recipients of solid organ transplantation.
abstract: Regulatory T cells (Tregs) are considered to be critical for the induction of transplant tolerance. Tregs counts were measured in blood, biopsy and urine sample after transplantation in many studies. Although not unanimous, some studies have suggested that Tregs is associated with better outcome and can also serve as an immune marker to predict the individual risk of rejection and identify tolerant patients. In this study, we systematically reviewed the correlation between Tregs and transplant outcomes, identifying if Tregs can predict transplant rejection and tolerance. A total of 22 articles were included and assessed, the results showed that Tregs in recipients are helpful to maintain a stable graft function, reduce acute/chronic rejection rate. And the Tregs in graft and urine, rather than in PBL, may have a better diagnostic value for transplant outcomes. However, since the low quality of included studies, results may be influenced by bias. More high quality studies with bigger sample size are still needed in future.
authors.affiliation: Key Laboratory of Transplant Engineering and Immunology of Health Ministry of China, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan Province, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Shan
authors.forename: Yinjia
authors.initials: Y
authors.lastname: Guo
authors.forename: Lei
authors.initials: L
authors.lastname: Luo
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.forename: Chengwen
authors.initials: C
authors.lastname: Li
authors.forename: Chuntao
authors.initials: C
authors.lastname: Zhang
authors.forename: Yuchuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Li
authors.initials: L
authors.lastname: Feng
authors.forename: Wenqiao
authors.initials: W
authors.lastname: Wu
authors.forename: Dan
authors.initials: D
authors.lastname: Long
authors.forename: Shengfu
authors.initials: S
authors.lastname: Li
authors.forename: Youping
authors.initials: Y
authors.lastname: Li
mesh_terms: D018791:CD4 Lymphocyte Count; D002986:Clinical Trials as Topic; D051858:Forkhead Transcription Factors / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D008297:Male; D016377:Organ Transplantation; D011237:Predictive Value of Tests; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014181:Transplantation Immunology; D016896:Treatment Outcome
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors