title: Liver transplantation for acute liver failure: the Hungarian experience.
abstract: Acute liver failure (ALF) counts for 9%-11% of activity in leading liver transplant programs. We have summarized the Hungarian Liver Transplant Program experience for ALF among 412 consecutive orthotopic liver transplantations (OLTs). All OLTs were performed without an extended international donor background. The proportion of ALF among the indications for OLT was lower (5.8% vs 9%) and early mortality higher than the European Liver Transplant Registry (1 year cumulative patients survival is 70% in ELTR vs 60% in the HU LT Program). The waiting time for a donor was longer than expected in the Eurotransplant community. Regarding postoperative complications, there was a higher incidence of initial poor function, bacterial infection, sepsis, and multiorgan failure. We conclude that ALF can be managed with reasonable results but requires an extended donor pool with an integrated international network to improve postoperative morbidity and mortality.
authors.affiliation: Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary. abnemes@hotmail.com
authors.forename: B
authors.initials: B
authors.lastname: Nemes
authors.forename: G
authors.initials: G
authors.lastname: Zádori
authors.forename: D
authors.initials: D
authors.lastname: Görög
authors.forename: I
authors.initials: I
authors.lastname: Fehérvári
authors.forename: L
authors.initials: L
authors.lastname: Kóbori
authors.forename: R M
authors.initials: RM
authors.lastname: Langer
mesh_terms: D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000209:etiology; D002648:Child; D005260:Female; D006801:Humans; D006814:Hungary; D017114:Liver Failure, Acute / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D055031:Primary Graft Dysfunction / Q000209:etiology; D015397:Program Evaluation; D018805:Sepsis / Q000209:etiology; D015996:Survival Rate; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution; D016896:Treatment Outcome; D014850:Waiting Lists; D055815:Young Adult