title: Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma.
abstract: This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin, with a partial response and normalization of α fetoprotein, which allowed curative surgery. The potential synergy between these three drugs needs to be confirmed, and is currently being investigated in a randomized phase II trial.
authors.affiliation: Department of Gastroenterology, Europeen Georges Pompidou Hospital, Medical University, 75908 Paris, France. nwilliet@yahoo.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Williet
authors.forename: Olivier
authors.initials: O
authors.lastname: Dubreuil
authors.forename: Tarek
authors.initials: T
authors.lastname: Boussaha
authors.forename: Isabelle
authors.initials: I
authors.lastname: Trouilloud
authors.forename: Bruno
authors.initials: B
authors.lastname: Landi
authors.forename: Martin
authors.initials: M
authors.lastname: Housset
authors.forename: Muriel
authors.initials: M
authors.lastname: Botti
authors.forename: Philippe
authors.initials: P
authors.lastname: Rougier
authors.forename: Jacques
authors.initials: J
authors.lastname: Belghiti
authors.forename: Julien
authors.initials: J
authors.lastname: Taieb
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001557:Benzenesulfonates / Q000008:administration & dosage / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009536:Niacinamide / Q000031:analogs & derivatives; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D000077150:Oxaliplatin; D010671:Phenylurea Compounds; D011725:Pyridines / Q000008:administration & dosage / Q000627:therapeutic use*; D000077157:Sorafenib; D000093542:Gemcitabine
chemical_list: D001557:Benzenesulfonates; D009944:Organoplatinum Compounds; D010671:Phenylurea Compounds; D011725:Pyridines; D000077150:Oxaliplatin; D003841:Deoxycytidine; D009536:Niacinamide; D000077157:Sorafenib; D000093542:Gemcitabine