title: Evaluation of four drugs for inhibition of paracentesis-induced blood-aqueous humor barrier breakdown in cats.
abstract: OBJECTIVE
  To compare inhibitory effects of topically applied 1% prednisolone acetate suspension, 0.03% flurbiprofen solution, 0.1% dexamethasone suspension, and 0.1% diclofenac solution on paracentesis-induced blood-aqueous barrier breakdown in cats.
  
  
  METHODS
  9 healthy cats.
  
  
  METHODS
  Paracentesis of the anterior chamber was performed in both eyes of each cat. One eye of each cat was treated with a topically administered anti-inflammatory medication (1% prednisolone [n = 7 cats], 0.03% flurbiprofen [7], 0.1% dexamethasone [9], or 0.1% diclofenac [8]) immediately following paracentesis and at 6, 10, and 24 hours after paracentesis. The contralateral untreated eye served as the control eye. Each cat had a 6-day washout period between experimental drugs. Breakdown of the blood-aqueous barrier was quantified by use of laser flaremetry.
  
  
  RESULTS
  Topical administration of 1% prednisolone significantly reduced aqueous humor flare at 4, 8, and 26 hours after paracentesis. Topical administration of 0.1% diclofenac significantly reduced aqueous humor flare at 8 and 26 hours after paracentesis. Topical administration of 0.1% dexamethasone and 0.03% flurbiprofen did not significantly decrease flare at any time point. There were significant differences in intraocular pressures between NSAID-treated eyes and untreated contralateral eyes.
  
  
  CONCLUSIONS
  Topical administration of 1% prednisolone and 0.1% diclofenac significantly reduced intraocular inflammation in cats with paracentesis-induced uveitis. Topical administration of 1% prednisolone or 0.1% diclofenac may be appropriate choices when treating cats with anterior uveitis. Topical administration of diclofenac and flurbiprofen should be used with caution in cats with a history of ocular hypertension.
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA. arankin@vet.k-state.edu
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Rankin
authors.forename: Sheryl G
authors.initials: SG
authors.lastname: Khrone
authors.forename: Jean
authors.initials: J
authors.lastname: Stiles
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001082:Aqueous Humor / Q000187:drug effects; D018916:Blood-Aqueous Barrier / Q000187:drug effects* / Q000503:physiopathology; D002371:Cat Diseases / Q000188:drug therapy* / Q000503:physiopathology; D002415:Cats; D004008:Diclofenac / Q000494:pharmacology*; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology*; D007429:Intraocular Pressure; D008297:Male; D009798:Ocular Hypertension / Q000188:drug therapy / Q000662:veterinary; D019152:Paracentesis; D011246:Pregnadienetriols / Q000494:pharmacology*; D014606:Uveitis, Anterior / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000893:Anti-Inflammatory Agents; D011246:Pregnadienetriols; D004008:Diclofenac; D005480:Flurbiprofen