title: Endoscopic submucosal dissection in a European setting. A multi-institutional report of a technique in development.
abstract: OBJECTIVE
  Endoscopic submucosal dissection (ESD) is a technique for "en bloc" resection of superficial tumors of the gastrointestinal tract. In France, experience with this technique is still limited. We wanted to assess the development of ESD in France, with special attention to short term outcomes.
  
  
  METHODS
  Members of the Société Française d'Endoscopie Digestive (SFED) who declared performing ESD reported their cases prospectively on a voluntary basis. Demographic, clinical, and technical data, and the results of immediate complications were collected. Case reports were completed prospectively by each investigator before pooled analysis.
  
  
  RESULTS
  A total of 188 consecutive case reports were collected from 16 centers. The median case mix per center was 6 patients (range 1-43). The lesion sites treated by ESD were the stomach (n = 75), esophagus (n = 27), duodenum (n = 1), cecum (n = 2), right colon (n = 3), transverse colon (n = 5), sigmoid (n = 3), and rectum (n = 72). The median size of the lesions was 26 mm (range 2-150 mm). En bloc resection was achieved in 77.1% of cases, with complete R0 resection in 72.9%. Histopathology results showed high grade dysplasia or superficial cancer in 71.2%. The median duration of ESD was 105 minutes (range 20-450 minutes). The short term morbidity was 29.2% including 34 cases of perforation (18.1%), and 21 hemorrhages (11.2%) during the 24 hours following ESD, 89% of which were managed conservatively or endoscopically.
  
  
  CONCLUSIONS
  In this early experience, the feasibility of ESD appeared to be good but R0 resection and complication rates did not match those reported by Japanese authors and must be improved by an extended practice.
authors.affiliation: Hôpital Cochin, Paris.
authors.forename: S
authors.initials: S
authors.lastname: Farhat
authors.forename: S
authors.initials: S
authors.lastname: Chaussade
authors.forename: T
authors.initials: T
authors.lastname: Ponchon
authors.forename: D
authors.initials: D
authors.lastname: Coumaros
authors.forename: A
authors.initials: A
authors.lastname: Charachon
authors.forename: T
authors.initials: T
authors.lastname: Barrioz
authors.forename: S
authors.initials: S
authors.lastname: Koch
authors.forename: P
authors.initials: P
authors.lastname: Houcke
authors.forename: C
authors.initials: C
authors.lastname: Cellier
authors.forename: D
authors.initials: D
authors.lastname: Heresbach
authors.forename: V
authors.initials: V
authors.lastname: Lepilliez
authors.forename: B
authors.initials: B
authors.lastname: Napoleon
authors.forename: P
authors.initials: P
authors.lastname: Bauret
authors.forename: E
authors.initials: E
authors.lastname: Coron
authors.forename: M
authors.initials: M
authors.lastname: Le Rhun
authors.forename: P
authors.initials: P
authors.lastname: Bichard
authors.forename: E
authors.initials: E
authors.lastname: Vaillant
authors.forename: A
authors.initials: A
authors.lastname: Calazel
authors.forename: E
authors.initials: E
authors.lastname: Bensoussan
authors.forename: S
authors.initials: S
authors.lastname: Bellon
authors.forename: L
authors.initials: L
authors.lastname: Mangialavori
authors.forename: F
authors.initials: F
authors.lastname: Robin
authors.forename: F
authors.initials: F
authors.lastname: Prat
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016063:Blood Loss, Surgical; D004210:Dissection / Q000009:adverse effects / Q000379:methods*; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005602:France; D005753:Gastric Mucosa / Q000601:surgery*; D005770:Gastrointestinal Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007413:Intestinal Mucosa / Q000601:surgery*; D007416:Intestinal Perforation / Q000209:etiology*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000209:etiology*; D013997:Time Factors