title: Fine tuning our cellular factories: sirtuins in mitochondrial biology.
abstract: Sirtuins have emerged in recent years as critical regulators of metabolism, influencing numerous facets of energy and nutrient homeostasis. Here, we review recent advances on the role of this fascinating family of mammalian proteins and their well-orchestrated function in modulating mitochondrial activity.
authors.affiliation: The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhong
authors.forename: Raul
authors.initials: R
authors.lastname: Mostoslavsky
mesh_terms: D000085:Acetates / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D002952:Citric Acid Cycle; D004579:Electron Transport; D006019:Glycolysis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism; D018384:Oxidative Stress; D015398:Signal Transduction; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D000085:Acetates; D007328:Insulin; D037761:Sirtuins