title: Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure.
abstract: BACKGROUND
  The WNT4 gene plays an important role in female sex determination and differentiation. It also contributes to maintaining of the ovaries and the survival of follicles.
  
  
  METHODS
  We sequenced the coding region and splice sites of WNT4 in 145 Han Chinese women with premature ovarian failure (POF) and 200 healthy controls.
  
  
  RESULTS
  Only one novel variation, in Exon 2 (195C > T), was detected among the women with POF. However, this synonymous variation did not result in a change in amino acid sequence (65 Asp > Asp). No further variants were found in any of the samples.
  
  
  CONCLUSIONS
  Although we cannot provide any evidence that it is a possible disease-causing gene, this study is the first attempt to investigate the possible role of WNT4 in Han Chinese women with POF.
authors.affiliation: Reproductive Medicine Center, First Affiliated Hospital, Anhui Medical University, Hefei, PR China.
authors.forename: Beili
authors.initials: B
authors.lastname: Chen
authors.forename: Peisu
authors.initials: P
authors.lastname: Suo
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: Sirui
authors.initials: S
authors.lastname: Zhou
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D020022:Genetic Predisposition to Disease; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D051153:Wnt Proteins / Q000235:genetics*; D060528:Wnt4 Protein; D055815:Young Adult
chemical_list: C555581:WNT4 protein, human; D051153:Wnt Proteins; D060528:Wnt4 Protein; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone