title: [Changing epidemiology of native valve infective endocarditis].
abstract: OBJECTIVE
  The aim of our study is to assess changes in the epidemiologic features of patients with native valve infective endocarditis.
  
  
  METHODS
  We analyzed a prospective series of 228 cases of native valve infective endocarditis in non-intravenous drug users attending our center between 1987 and 2009. We compared three subperiods: 1987-1994 (67 cases), 1995-2002 (74 cases) and 2003-2009 (87 cases).
  
  
  RESULTS
  The mean age of patients has progressively increased (38±22 years in the first subperiod vs 60±16 years in the third; P<.001), as has the proportion of cases without predisposing heart disease (25%, 46% and 67%; P<.001). Incidence of mitral valve prolapse remained stable (12%, 18% and 11%). Percentages of patients with predisposing heart disease and who were aware of their condition have fallen in recent years (45%, 27% and 21%; P<.001). A portal of entry for the infection could not be identified in 64%. Overall, Staphylococcus aureus is the most frequent causative organism (26%) whereas the percentage of cases caused by Streptococcus viridans remains unaltered (22%, 20% and 24%).
  
  
  CONCLUSIONS
  We found significant changes in the epidemiology of native valve infective endocarditis. The incidence of patients without predisposing heart disease has increased significantly and staphylococci are the most frequent causative organisms. Full English text available from: www.revespcardiol.org.
authors.affiliation: Servicio de Cardiología, Hospital Universitario Reina Sofía, Córdoba, Spain. jcastillod@medynet.com
authors.forename: Juan C
authors.initials: JC
authors.lastname: Castillo
authors.forename: Manuel P
authors.initials: MP
authors.lastname: Anguita
authors.forename: Martín
authors.initials: M
authors.lastname: Ruiz
authors.forename: Luisa
authors.initials: L
authors.lastname: Peña
authors.forename: Marta
authors.initials: M
authors.lastname: Santisteban
authors.forename: Miguel
authors.initials: M
authors.lastname: Puentes
authors.forename: José M
authors.initials: JM
authors.lastname: Arizón
authors.forename: José
authors.initials: J
authors.lastname: Suárez de Lezo
mesh_terms: D000328:Adult; D000368:Aged; D004697:Endocarditis, Bacterial / Q000453:epidemiology* / Q000382:microbiology / Q000601:surgery; D005260:Female; D006331:Heart Diseases / Q000150:complications / Q000453:epidemiology / Q000382:microbiology; D006349:Heart Valve Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000453:epidemiology / Q000382:microbiology; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000453:epidemiology; D055815:Young Adult