title: Short- and long-term outcomes in children undergoing radiofrequency catheter ablation before their second birthday.
abstract: BACKGROUND
  Tachyarrhythmias can cause substantial morbidity and mortality in infants and very young children. Our objective was to assess early and late outcomes in children undergoing radiofrequency catheter ablation before their second birthday.
  
  
  METHODS
  This is a retrospective review of medical records from 1995 till 2009 at a single institution with a large referral base.
  
  
  RESULTS
  Thirty-four children younger than 2 years of age were brought to the electrophysiology laboratory for catheter ablation for tachyarrhythmia. Radiofrequency ablation (42 procedures) was performed in 31 children (mean weight, 7.4 kg; range, 2.6-12.3 kg). Tachyarrhythmias were atrioventricular re-entry tachycardia (19), ectopic or multifocal atrial tachycardia (6), atrial flutter (1), ventricular tachycardia (3), and congenital junctional ectopic tachycardia (2). Seventeen children presented with tachycardia-induced cardiomyopathy and heart failure. Three patients required extracorporeal life support prior to the procedure. Radiofrequency catheter ablation was successful in 74% of these very young children vs 91% in a comparison group of children older than 2 years (n = 447). Among patients with initially successful ablations, there was no tachyarrhythmia recurrence during medium- to long-term follow-up (1.4-15.0 years; mean, 7.3 years). Major complications occurred in 4 very young children. Eight of 11 patients in whom ablation failed or could not be done required another form of continued aggressive treatment.
  
  
  CONCLUSIONS
  Catheter ablation is indicated and successful in critically ill infants with life-threatening tachyarrhythmia refractory to medical therapy. Initially successful procedures are associated with excellent long-term outcomes, but significant complication rates require that such procedures be reserved for carefully selected patients and performed by highly skilled staff.
authors.affiliation: Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada. michal.kantoch@albertahealthservices.ca
authors.forename: Michal J
authors.initials: MJ
authors.lastname: Kantoch
authors.forename: Sajad S
authors.initials: SS
authors.lastname: Gulamhusein
authors.forename: Shubhayan
authors.initials: S
authors.lastname: Sanatani
mesh_terms: D017115:Catheter Ablation / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D013610:Tachycardia / Q000209:etiology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome