title: Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans.
abstract: Ypd1 is a key phosphorelay protein that controls eukaryotic two-component systems, but its function in Cryptococcus neoformans is not known. Here, we report that Ypd1 is required for the viability of C. neoformans via the Hog1 mitogen-activated protein kinase (MAPK) pathway but plays multiple cellular roles in both a Hog1-dependent and -independent manner.
authors.affiliation: Department of Biotechnology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul, South Korea.
authors.forename: Jang-Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Ko
authors.forename: Seo-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Yong-Sun
authors.initials: YS
authors.lastname: Bahn
mesh_terms: D000595:Amino Acid Sequence; D003455:Cryptococcus neoformans / Q000235:genetics / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D055786:Gene Knockout Techniques; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D010770:Phosphotransferases / Q000235:genetics* / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D015398:Signal Transduction; D013312:Stress, Physiological; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D037521:Virulence Factors; D010770:Phosphotransferases; D011494:Protein Kinases; D020928:Mitogen-Activated Protein Kinases