title: Steroid hormone hypersensitivity: clinical presentation and management.
abstract: Hypersensitivity to estrogens and progestogens is often undiagnosed. The condition has many manifestations, including premenstrual syndrome, dysmenorrhea, and impaired fertility. Diagnosis is confirmed by skin testing for inflammatory responses to small doses of the hormone, and desensitization with small doses of the hormone is the most appropriate form of management.
authors.affiliation: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel. itsekson@netvision.net.il
authors.forename: Alek M
authors.initials: AM
authors.lastname: Itsekson
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Seidman
authors.forename: Matityahu
authors.initials: M
authors.lastname: Zolti
authors.forename: Michael
authors.initials: M
authors.lastname: Alesker
authors.forename: Howard J A
authors.initials: HJ
authors.lastname: Carp
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D003872:Dermatitis; D003888:Desensitization, Immunologic; D019587:Dietary Supplements; D004412:Dysmenorrhea / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D004967:Estrogens / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D007246:Infertility / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011293:Premenstrual Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011374:Progesterone / Q000009:adverse effects* / Q000627:therapeutic use; D012882:Skin Tests; D016896:Treatment Outcome
chemical_list: D004967:Estrogens; D011374:Progesterone