title: Architecture and development of the Neurospora crassa hypha -- a model cell for polarized growth.
abstract: Neurospora crassa has been at the forefront of biological research from the early days of biochemical genetics to current progress being made in understanding gene and genetic network function. Here, we discuss recent developments in analysis of the fundamental form of fungal growth, development and proliferation -- the hypha. Understanding the establishment and maintenance of polarity, hyphal elongation, septation, branching and differentiation are at the core of current research. The advances in the identification and functional dissection of regulatory as well as structural components of the hypha provide an expanding basis for elucidation of fundamental attributes of the fungal cell. The availability and continuous development of various molecular and microscopic tools, as utilized by an active and co-supportive research community, promises to yield additional important new discoveries on the biology of fungi.
authors.affiliation: Center for Scientific Research and Higher Education of Ensenada - CICESE, Ensenada Baja California 22860, Mexico. riquelme@cicese.mx
authors.forename: Meritxell
authors.initials: M
authors.lastname: Riquelme
authors.forename: Oded
authors.initials: O
authors.lastname: Yarden
authors.forename: Salomon
authors.initials: S
authors.lastname: Bartnicki-Garcia
authors.forename: Barry
authors.initials: B
authors.lastname: Bowman
authors.forename: Ernestina
authors.initials: E
authors.lastname: Castro-Longoria
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Free
authors.forename: Andre
authors.initials: A
authors.lastname: Fleissner
authors.forename: Michael
authors.initials: M
authors.lastname: Freitag
authors.forename: Roger R
authors.initials: RR
authors.lastname: Lew
authors.forename: Rosa
authors.initials: R
authors.lastname: Mouriño-Pérez
authors.forename: Michael
authors.initials: M
authors.lastname: Plamann
authors.forename: Carolyn
authors.initials: C
authors.lastname: Rasmussen
authors.forename: Corinna
authors.initials: C
authors.lastname: Richthammer
authors.forename: Robert W
authors.initials: RW
authors.lastname: Roberson
authors.forename: Eddy
authors.initials: E
authors.lastname: Sanchez-Leon
authors.forename: Stephan
authors.initials: S
authors.lastname: Seiler
authors.forename: Michael K
authors.initials: MK
authors.lastname: Watters
mesh_terms: D016764:Cell Polarity; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D025301:Hyphae / Q000166:cytology* / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D008954:Models, Biological; D009492:Neurospora crassa / Q000166:cytology / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism
chemical_list: D005656:Fungal Proteins