title: Impaired mobilization of bone marrow derived CD34 positive mononuclear cells is related to the recurrence of atrial fibrillation after radiofrequency catheter ablation.
abstract: BACKGROUND
  We have reported previously that non-ischemic titrated cardiac injury by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) mobilizes bone marrow derived CD34+ mononuclear cells. We hypothesized that the degree of post-RFCA CD34+ cell mobilization affects the clinical outcome of AF ablation.
  
  
  RESULTS
  Fifty-six patients (39 males, 53 ± 13 years) who underwent electrophysiology study (EPS; n=10) or RFCA of AF (n=46) were included. The peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after the procedure.
  
  
  RESULTS
  1. The percent increase of CD34+ cells (%ΔCD34+) was significant after RFCA as compared to EPS (p < 0.01). 2. The post-RFCA CD34+ cell count was significantly higher in patients who underwent RF energy delivery ≥80 min than those <80 min (p = 0.024). 3. The %ΔCD34+ was linearly correlated with the plasma level of troponin I (R = 0.38, p < 0.01), but not with the non-ablation procedure time (p = NS). 3. During 30.2 ± 2.7 months follow-up, AF recurred in 37% of patients including early recurrence (34.8%). In contrast, the patients in whom AF recurred received a longer duration of RF energy delivery than those remaining in sinus rhythm (p = 0.04), they were associated with lower %ΔCD34+ (p = 0.02).
  
  
  CONCLUSIONS
  CD34+ mononuclear cells were mobilized after catheter ablation by RF energy dose dependent manner, and the duration of RF energy delivery was longer in patients with AF recurrence. However, CD34+ mononuclear cell mobilization was significantly impaired in patients with recurring AF after RFCA.
authors.affiliation: Yonsei University Health System, Seoul, Republic of Korea.
authors.forename: Jaemin
authors.initials: J
authors.lastname: Shim
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Park
authors.forename: Jong Youn
authors.initials: JY
authors.lastname: Kim
authors.forename: Sook Kyoung
authors.initials: SK
authors.lastname: Kim
authors.forename: Boyoung
authors.initials: B
authors.lastname: Joung
authors.forename: Moon-Hyoung
authors.initials: MH
authors.lastname: Lee
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Kim
authors.forename: Hui-Nam
authors.initials: HN
authors.lastname: Pak
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000096:biosynthesis*; D001281:Atrial Fibrillation / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D001854:Bone Marrow Cells / Q000378:metabolism*; D017115:Catheter Ablation / Q000009:adverse effects*; D002465:Cell Movement / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34