title: Testosterone deficiency and risk factors in the metabolic syndrome: implications for erectile dysfunction.
abstract: The most common cause of erectile dysfunction (ED) is penile vascular insufficiency. This is usually part of a generalized endothelial dysfunction and is related to several conditions, including type 2 diabetes mellitus, hypertension, hyperlipidemia, and obesity. These conditions underlie the pathophysiology of metabolic syndrome (MetS). Hypogonadism, or testosterone deficiency (TD), is an integral component of the pathology underlying endothelial dysfunction and MetS, with insulin resistance (IR) at its core. Testosterone replacement therapy for TD has been shown to ameliorate some of the components of the MetS, improve IR, and may serve as treatment for decreasing cardiovascular and ED risk.
authors.affiliation: Center for Sexual Function/Department of Endocrinology, Lahey Clinic, Northshore One Essex Center Drive, Peabody, MA 01960, USA. Andre.T.Guay@Lahey.org
authors.forename: Andre T
authors.initials: AT
authors.lastname: Guay
authors.forename: Abdulmaged
authors.initials: A
authors.lastname: Traish
mesh_terms: D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000503:physiopathology*; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000503:physiopathology*; D012307:Risk Factors; D013739:Testosterone / Q000172:deficiency* / Q000627:therapeutic use*
chemical_list: D013739:Testosterone