title: Locked and unlocked nucleosides in functional nucleic acids.
abstract: Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.
authors.affiliation: Nucleic Acid Center, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M 5230, Denmark.
authors.forename: Holger
authors.initials: H
authors.lastname: Doessing
authors.forename: Birte
authors.initials: B
authors.lastname: Vester
mesh_terms: D021881:DNA, Catalytic / Q000737:chemistry / Q000378:metabolism; D009696:Nucleic Acids / Q000737:chemistry* / Q000378:metabolism; D009705:Nucleosides / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism
chemical_list: D021881:DNA, Catalytic; D009696:Nucleic Acids; D009705:Nucleosides; D009841:Oligonucleotides; D016337:RNA, Catalytic