title: [Association of HLA DRB1 polymorphism with susceptibility to myelodysplastic syndrome and aplastic anemia in Chinese Han population].
abstract: OBJECTIVE
  To investigate the association of the HLA-DRB1 polymorphism with susceptibility to myelodysplastic syndrome (MDS) and aplastic anemia (AA) in Chinese Han population.
  
  
  METHODS
  The polymorphism of HLA-DRB1 alleles in 242 patients with MDS, 115 patients with AA and 2264 umbilical cord blood control samples were tested by polymerase chain reaction-sequence specific primer (PCR-SSP).
  
  
  RESULTS
  Compared with normal controls, the frequency of HLA-DRB1*15 was significantly increased in the MDS group and AA group (22.93% vs. 17.25%, Chi-square = 9.662, OR= 1.428, P= 0.003; 26.52% vs. 17.25%, Chi-square = 12.924, OR= 1.732, P= 0.001). And this is mainly due to the increase in the male patients in both patient groups: in the MDS males, 24.68% vs. 17.25%, Chi-square= 11.194, OR= 1.572, P= 0.001, and in the AA males, 29.29% vs. 17.25%, Chi-square= 13.563, OR= 1.987, P= 0.001. No significant difference between the controls and the female patients in both groups was observed.
  
  
  CONCLUSIONS
  The HLA-DRB1*15 could be a susceptibility allele for MDS and AA male patients.
authors.affiliation: HLA Laboratory, Peking University Institute of Hematology and Peking University People's Hospital, Beijing, 100044 P. R. China.
authors.forename: Ming-rui
authors.initials: MR
authors.lastname: Huo
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Xi
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Dan
authors.initials: D
authors.lastname: Li
mesh_terms: D000483:Alleles; D000741:Anemia, Aplastic / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains