title: Function of K⁺-Cl⁻ cotransporters in the acid secretory mechanism of gastric parietal cells.
abstract: Gastric proton pump (H⁺, K⁺-ATPase) secretes H⁺ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl⁻- and K⁺-transporting proteins are required. Recent our studies have demonstrated that K⁺-Cl⁻ cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na⁺, K⁺-ATPase in the basolateral membrane, and KCC4 is associated with H⁺, K⁺-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.
authors.affiliation: Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan. fujiitk@pha.u-toyama.ac.jp
authors.forename: Takuto
authors.initials: T
authors.lastname: Fujii
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Fujita
authors.forename: Noriaki
authors.initials: N
authors.lastname: Takeguchi
authors.forename: Hideki
authors.initials: H
authors.lastname: Sakai
mesh_terms: D000818:Animals; D016764:Cell Polarity; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism; D010295:Parietal Cells, Gastric / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D017494:Proton Pumps / Q000378:metabolism; D055571:Secretory Pathway; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D027981:Symporters / Q000378:metabolism*; D000096922:K Cl- Cotransporters
chemical_list: D020033:Protein Isoforms; D017494:Proton Pumps; D000254:Sodium-Potassium-Exchanging ATPase; D027981:Symporters; C119650:SLC12A6 protein, human; D000096922:K Cl- Cotransporters; C119651:SLC12A7 protein, human