title: Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.
abstract: Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.
authors.affiliation: Novartis Institute for Tropical Diseases, #05-01 Chromos, 10 Biopolis road, Singapore 138670, Singapore. Yixiong_heng@immunol.a-star.edu.sg
authors.forename: YiXiong
authors.initials: Y
authors.lastname: Heng
authors.forename: Peck Gee
authors.initials: PG
authors.lastname: Seah
authors.forename: Jie Yee
authors.initials: JY
authors.lastname: Siew
authors.forename: Hui Chien
authors.initials: HC
authors.lastname: Tay
authors.forename: Amit
authors.initials: A
authors.lastname: Singhal
authors.forename: Vanessa
authors.initials: V
authors.lastname: Mathys
authors.forename: Mehdi
authors.initials: M
authors.lastname: Kiass
authors.forename: Pablo
authors.initials: P
authors.lastname: Bifani
authors.forename: Véronique
authors.initials: V
authors.lastname: Dartois
authors.forename: Maxime
authors.initials: M
authors.lastname: Hervé
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006099:Granuloma / Q000382:microbiology*; D000860:Hypoxia / Q000473:pathology*; D007150:Immunohistochemistry; D008168:Lung / Q000382:microbiology / Q000473:pathology*; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D009593:Nitroimidazoles / Q000494:pharmacology*; D051381:Rats; D014397:Tuberculosis, Pulmonary / Q000473:pathology*
chemical_list: D009593:Nitroimidazoles; C033815:pimonidazole