title: Monoclonal immunoscintigraphy for detection of metastasis and recurrence of colorectal cancer.
abstract: OBJECTIVE
  To assess the clinical role of monoclonal immunoscintigraphy for the detection of metastasis and recurrence of colorectal cancer.
  
  
  METHODS
  Monoclonal immunoscintigraphy was performed in patients operated on for colorectal adenocarcinoma suspected of local recurrence and metastatic disease. The results were compared with conventional diagnostics.
  
  
  RESULTS
  Immunoscintigraphic investigation was done in 53 patients. Tumor recurrence occurred in 38 patients, and was confirmed by other diagnostic modalities in 35. In 15 patients, immunoscintigraphic findings were negative, and confirmed in 14 with other diagnostic methods. Comparative analysis confirmed good correlation of immunoscintigraphic findings and the results of conventional diagnostics and the level of tumor marker carcinoembryonic antigen. Statistical analysis of parameters of radiopharmaceutical groups imacis, indimacis and oncoscint presented homogenous characteristics all of three radiopharmaceuticals. The analysis of immunoscintigraphic target focus was clearly improved using tomography.
  
  
  CONCLUSIONS
  Immunoscintigraphy is highly specific and has a good predictive value in local recurrence of colorectal cancer.
authors.affiliation: School of Medicine, University of Belgrade, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia. veraart@beotel.net
authors.forename: Vera
authors.initials: V
authors.lastname: Artiko
authors.forename: Ana Koljevic
authors.initials: AK
authors.lastname: Marković
authors.forename: Dragana
authors.initials: D
authors.lastname: Sobić-Šaranović
authors.forename: Milorad
authors.initials: M
authors.lastname: Petrović
authors.forename: Andrija
authors.initials: A
authors.lastname: Antić
authors.forename: Mirjana
authors.initials: M
authors.lastname: Stojković
authors.forename: Marinko
authors.initials: M
authors.lastname: Zuvela
authors.forename: Djordjije
authors.initials: D
authors.lastname: Saranović
authors.forename: Milica
authors.initials: M
authors.lastname: Stojković
authors.forename: Nebojša
authors.initials: N
authors.lastname: Radovanović
authors.forename: Danijel
authors.initials: D
authors.lastname: Galun
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Milovanović
authors.forename: Jovica
authors.initials: J
authors.lastname: Milovanović
authors.forename: Anica
authors.initials: A
authors.lastname: Bobić-Radovanović
authors.forename: Zoran
authors.initials: Z
authors.lastname: Krivokapic
authors.forename: Vladimir
authors.initials: V
authors.lastname: Obradović
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary*; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011237:Predictive Value of Tests; D016719:Radioimmunodetection / Q000379:methods*; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D019275:Radiopharmaceuticals