title: Pituitary autoimmunity is associated with hypopituitarism in patients with primary empty sella.
abstract: OBJECTIVE
  Some evidence suggests that late stage autoimmune hypophysitis (AH) may result in empty sella (ES). Aim of the study was to assess the prevalence of serum pituitary antibodies (PitAb) and their correlation with pituitary function in patients with ES.
  
  
  METHODS
  In this casecontrol study 85 patients with primary ES, 16 patients with ES secondary to head trauma, 214 healthy controls, and 16 AH were enrolled in a tertiary referral center.
  
  
  METHODS
  PitAb were assessed in all cases and controls. Endocrine function was assessed by basal hormone measurement and dynamic testing in all ES cases.
  
  
  RESULTS
  PitAb prevalence was higher in primary ES (6%) than in healthy subjects (0.5% p=0.003) and lower than in AH patients (50%, p<0.0001). PitAb were not found in patients with secondary ES. Hypopituitarism was found in 49% of primary ES and in 62% of secondary ES (p=0.34). A positive correlation between the presence of PitAb and hypopituitarism was found in primary ES (p=0.02).
  
  
  CONCLUSIONS
  The significant association between pituitary autoimmunity and hypopituitarism suggests that ES, in selected cases, could be the final result of AH.
authors.affiliation: Department of Endocrinology and Metabolism, University of Pisa, Ospedale Cisanello, via Paradisa, 2 56124 Pisa, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Lupi
authors.forename: L
authors.initials: L
authors.lastname: Manetti
authors.forename: V
authors.initials: V
authors.lastname: Raffaelli
authors.forename: L
authors.initials: L
authors.lastname: Grasso
authors.forename: C
authors.initials: C
authors.lastname: Sardella
authors.forename: M
authors.initials: M
authors.lastname: Cosottini
authors.forename: A
authors.initials: A
authors.lastname: Iannelli
authors.forename: M
authors.initials: M
authors.lastname: Gasperi
authors.forename: F
authors.initials: F
authors.lastname: Bogazzi
authors.forename: P
authors.initials: P
authors.lastname: Caturegli
authors.forename: E
authors.initials: E
authors.lastname: Martino
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D004652:Empty Sella Syndrome / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000276:immunology* / Q000502:physiology
chemical_list: D001323:Autoantibodies