title: Total synthesis of (±)-chamobtusin A.
abstract: The total synthesis of chamobtusin A, the first diterpenoid alkaloid isolated from the whole Pinales, is described. Key features of the synthesis include a stereoselective intramolecular Michael addition to install a key stereocenter and an oxidative manipulation to prepare a 2H-pyrrole ring.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Suzuki
authors.forename: Sakae
authors.initials: S
authors.lastname: Aoyagi
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D029780:Chamaecyparis / Q000737:chemistry*; D004224:Diterpenes / Q000138:chemical synthesis*; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D004224:Diterpenes; C525487:chamobtusin A