title: Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta.
abstract: Thelephora aurantiotincta is an edible mushroom belonging to the genus Thelephora; it grows in symbiosis with pine trees. Recently, phytochemical investigations have revealed that the genus Thelephora is an abundant source of p-terphenyl derivatives. However, their bioactivity has not yet been well characterized. In screening for natural materials with anticancer activity, a T. aurantiotincta ethanol extract (TAE) was found to decrease cell viability in human hepatocellular carcinoma cells (HepG2). In this study, a new p-terphenyl derivative, thelephantin O, and a known compound, vialinin A, were isolated as the principal bioactive components of TAE. These compounds decreased cell viability in HepG2 and human colonic carcinoma cells (Caco2), but not in noncancerous human hepatocytes. This is the first report of the isolation from T. aurantiotincta of selective cytotoxic agents against cancer cells.
authors.affiliation: Department of Nutrition, Aomori University of Health and Welfare, Hamadate, Aomori 030-8505, Japan. t_norikura@auhw.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Norikura
authors.forename: Kenshu
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Takanobu
authors.initials: T
authors.lastname: Narita
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Yae
authors.initials: Y
authors.lastname: Morinaga
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Iwai
authors.forename: Hajime
authors.initials: H
authors.lastname: Matsue
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D013730:Terphenyl Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013730:Terphenyl Compounds; C562008:thelephantin O; C508745:vialinin A