title: Primary cutaneous marginal zone lymphoma with subclinical cutaneous involvement and biclonality.
abstract: Primary cutaneous extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT) represents a monoclonal B-cell neoplasm that typically presents with papules, plaques or nodules. We describe a patient with a primary cutaneous MALT lymphoma with unusual clinical features and an unusual immunophenotype. Conventional microscopy together with immunohistochemistry and in-situ hybridization showed the presence of lymphoma in normal-appearing and minimally erythematous skin as well as in clinically involved skin. Furthermore, at least two distinct clones were shown, one of which had κ-light chain restriction, and the other of which had λ-light chain restriction. This case represents a newly described clinical appearance of primary cutaneous MZL and shows that some patients may have more than one neoplastic clone.
authors.affiliation: Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
authors.forename: James T
authors.initials: JT
authors.lastname: Edinger
authors.forename: Cynthia R
authors.initials: CR
authors.lastname: Lorenzo
authors.forename: Debra L
authors.initials: DL
authors.lastname: Breneman
authors.forename: Steven H
authors.initials: SH
authors.lastname: Swerdlow
mesh_terms: D000328:Adult; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis*; D007146:Immunoglobulin lambda-Chains / Q000096:biosynthesis*; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D009363:Neoplasm Proteins