title: Longitudinal study of childhood adiposity and the risk of developing components of metabolic syndrome-the Da Qing children cohort study.
abstract: Childhood adiposity is increasingly recognized as a significant predictor of cardiometabolic risks in later life. The aim of this study was to investigate factors associated with longitudinal changes in weight during childhood and the development of metabolic disease risk factors. Four hundred twenty-four children from DaQing city, China, were recruited at 5 y old and followed up for 5 y. Birth weight, television (TV) viewing time at 5 y old, blood pressure, anthropometric measurements, fasting plasma insulin (FI), and triglycerides (TG) levels were measured at 5 and 10 y old. Both birth weight and TV viewing time at 5 y old significantly correlated with percentage of ideal weight for height (WFH) at 5 y old (WFH5; p = 0.0032 and p = 0.01), but only TV time was significantly correlated with WFH at 10 y old (WFH10; p < 0.0001). Blood pressures, FI, homeostasis model assessment for insulin resistance (HOMA-IR), and TG at 10 y old were significantly greater in those children who had greater change in WFH from 5 to 10 y old (ΔWFH). We concluded that TV viewing time was the stronger determinant of later childhood adiposity. A greater ΔWFH was associated with increased cardiometabolic risk factors at 10 y old.
authors.affiliation: Endocrinology and Cardiovascular Disease Center, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. guangwei_li@medmail.com.cn
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Chen
authors.forename: Yung-Seng
authors.initials: YS
authors.lastname: Lee
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Wang
authors.forename: Ya-Yun
authors.initials: YY
authors.lastname: Jiang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: An
authors.forename: Ying-Hua
authors.initials: YH
authors.lastname: Hu
authors.forename: Kok O
authors.initials: KO
authors.lastname: Lee
authors.forename: Guang-Wei
authors.initials: GW
authors.lastname: Li
mesh_terms: D050154:Adiposity; D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D002681:China; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology* / Q000503:physiopathology*; D009765:Obesity / Q000209:etiology; D012307:Risk Factors; D013690:Television
chemical_list: D001786:Blood Glucose; D007328:Insulin