title: p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis.
abstract: p125/Sec23ip is a phospholipase A(1)-like protein that interacts with Sec23, a coat component of COPII vesicles that bud from endoplasmic reticulum exit sites. To understand its physiological function, we produced p125 knockout mice. The p125 knockout mice grew normally, but males were subfertile. Sperm from p125-deficient mice had round heads and lacked the acrosome, an organelle containing the enzymes responsible for fertilization. p125 was found to be expressed at stages I-XII of spermatogenesis, similar to the expression pattern of proteins involved in acrosome biogenesis. These results suggest that p125 plays an important role in spermiogenesis.
authors.affiliation: School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
authors.forename: Nagisa
authors.initials: N
authors.lastname: Arimitsu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kogure
authors.forename: Takashi
authors.initials: T
authors.lastname: Baba
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nakao
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hamamoto
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sekimizu
authors.forename: Akitsugu
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nakanishi
authors.forename: Ryo
authors.initials: R
authors.lastname: Taguchi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Tagaya
authors.forename: Katsuko
authors.initials: K
authors.lastname: Tani
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005298:Fertility / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D013091:Spermatogenesis / Q000502:physiology*; D013094:Spermatozoa / Q000002:abnormalities / Q000254:growth & development / Q000648:ultrastructure; D013737:Testis / Q000166:cytology / Q000254:growth & development; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; C561458:Sec23-interacting protein, mouse; C079038:Sec23a protein, mouse; D033921:Vesicular Transport Proteins