title: [Disturbances of lipid metabolism in the period of age androgen deficit in middle-aged and elderly men with ischemic stroke].
abstract: Blood concentrations of total cholesterol, beta-lipoproteins, triglycerides and testosterone were studied in 73 men (mean age 65.9 +/- 8.6 years) with acute ischemic stroke. The concentrations of testosterone and triglycerides in men decrease with age and those of cholesterol and beta-lipoproteins do not depend on the age. In middle-aged patients, the negative correlations were found between concentrations of testosterone and beta-lipoproteins (r = -0.404; p < 0.05); testosterone and cholesterol (r = -0.273; p < 0.001). In elderly patients, there were negative correlations between concentrations of testosterone and triglycerides (r = -0.348; p < 0.05). In middle-aged and elderly patients, concentrations of triglycerides and testosterone were negatively correlated (r = -0.478; p < 0.001). The lower blood testosterone level was associated with the higher risk of the development of atherosclerotic lesions of major arteries that allowed to estimate risks of ischemic stroke in middle-aged and elderly men.
authors.forename: B M
authors.initials: BM
authors.lastname: Doronin
authors.forename: O A
authors.initials: OA
authors.lastname: Denisova
mesh_terms: D000368:Aged; D000728:Androgens / Q000097:blood / Q000172:deficiency; D002784:Cholesterol / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D002537:Intracranial Arteriosclerosis / Q000097:blood* / Q000453:epidemiology*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood*; D013739:Testosterone / Q000097:blood / Q000172:deficiency*; D014280:Triglycerides / Q000097:blood
chemical_list: D000728:Androgens; D008077:Lipoproteins, LDL; D014280:Triglycerides; D013739:Testosterone; D002784:Cholesterol