title: Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1.
abstract: The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.
authors.affiliation: Department of Neurobiology, The Life Sciences Institute, Faculty of Science, Hebrew University of Jerusalem, Israel.
authors.forename: Arkady
authors.initials: A
authors.lastname: Khoutorsky
authors.forename: Arnon
authors.initials: A
authors.lastname: Heyman
authors.forename: Oded
authors.initials: O
authors.lastname: Shoseyov
authors.forename: Micha E
authors.initials: ME
authors.lastname: Spira
mesh_terms: D000818:Animals; D001048:Aplysia; D002462:Cell Membrane / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D009474:Neurons / Q000737:chemistry; D010316:Particle Size; D012825:Silicon / Q000737:chemistry; D016329:Sp1 Transcription Factor / Q000737:chemistry*; D013499:Surface Properties; D014867:Water / Q000737:chemistry; D017155:Wettability
chemical_list: D016329:Sp1 Transcription Factor; D014867:Water; D006046:Gold; D012825:Silicon