title: Metabonomics and its role in amino acid nutrition research.
abstract: Metabonomics combines metabolic profiling and multivariate data analysis to facilitate the high-throughput analysis of metabolites in biological samples. This technique has been developed as a powerful analytical tool and hence has found successful widespread applications in many areas of bioscience. Metabonomics has also become an important part of systems biology. As a sensitive and powerful method, metabonomics can quantitatively measure subtle dynamic perturbations of metabolic pathways in organisms due to changes in pathophysiological, nutritional, and epigenetic states. Therefore, metabonomics holds great promise to enhance our understanding of the complex relationship between amino acids and metabolism to define the roles for dietary amino acids in maintaining health and the development of disease. Such a technique also aids in the studies of functions, metabolic regulation, safety, and individualized requirements of amino acids. Here, we highlight the common workflow of metabonomics and some of the applications to amino acid nutrition research to illustrate the great potential of this exciting new frontier in bioscience.
authors.affiliation: Research Center for Healthy Breeding of Livestock and Poultry, Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha, Hunan, China 410125.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: He
authors.forename: Yulong
authors.initials: Y
authors.lastname: Yin
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Xiangfeng
authors.initials: X
authors.lastname: Kong
authors.forename: Guoyao
authors.initials: G
authors.lastname: Wu
authors.forename: Pingping
authors.initials: P
authors.lastname: Ren
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D004032:Diet; D044127:Epigenesis, Genetic; D006801:Humans; D055442:Metabolome; D055432:Metabolomics; D054647:Nutrigenomics; D009747:Nutritional Physiological Phenomena; D009751:Nutritional Requirements; D049490:Systems Biology
chemical_list: D000596:Amino Acids