title: Borderline ovarian mucinous neoplasm recurring as small cell carcinoma of hypercalcemic type: evidence for an epithelial histogenesis and relationship with ovarian mucinous tumors for this enigmatic neoplasm.
abstract: Ovarian small cell carcinoma of hypercalcemic type (OSCCHT) is an uncommon neoplasm of uncertain histogenesis. As far as we are aware, this neoplasm has never been reported in association with another primary ovarian tumor. We report a case in a 33-year-old patient in whom an extraovarian pericolonic neoplasm with the morphological features and immunohistochemical profile of OSCCHT developed 5 years after removal of an ovarian mucinous borderline tumor of the intestinal type. Together with the observation that mucinous epithelium is seen in some OSCCHTs, this case raises the possibility that this enigmatic neoplasm is of epithelial origin and is related to primary ovarian mucinous neoplasms. The pericolonic tumor exhibited an unusual immunophenotype with positive staining with CD99 and FLI-1, suggesting the possibility of a neoplasm in the Ewing family of tumors. This was excluded by molecular studies that showed no evidence of EWS/FLI-1 or EWS/ERG translocation.
authors.affiliation: Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland.
authors.forename: Sorsiah
authors.initials: S
authors.lastname: Mansor
authors.forename: Sri
authors.initials: S
authors.lastname: Nagarajan
authors.forename: Vaiyapuri P
authors.initials: VP
authors.lastname: Sumathi
authors.forename: W Glenn
authors.initials: WG
authors.lastname: McCluggage
mesh_terms: D000071443:12E7 Antigen; D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D000077216:Carcinoma, Ovarian Epithelial; D018288:Carcinoma, Small Cell / Q000145:classification / Q000150:complications / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000032:analysis; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D016130:Immunophenotyping; D008840:Microfilament Proteins / Q000032:analysis; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000473:pathology; D010051:Ovarian Neoplasms / Q000145:classification / Q000150:complications / Q000473:pathology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000032:analysis; D015534:Trans-Activators
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; C098179:FLII protein, human; D008840:Microfilament Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators