title: Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma.
abstract: Medulloblastoma (MB) is the most common malignant brain tumor of childhood. We have investigated for novel chromosomal imbalances and prognostic markers of pediatric MB. Forty MBs out of 64, were analyzed using high resolution prometaphase comparative genomic hybridization. Chromosome 10q26.1-q26.3 loss combined with 17q24.3-q25.3 gain and/or 7q34-q36.3 gain in tumors predicted poor patient's survival. A minimal deleted region of 14.12cM at 10q26.1-q26.3 was refined by LOH analysis. We propose a new prognostic marker for pediatric MB patient risk stratification based on the presence of 10q26.1-q26.3 loss plus 17q24.3-q25.3 gain and/or 7q34-q36.3 gain associations.
authors.affiliation: Department of Experimental and Laboratory Medicine, IRCCS G. Gaslini Hospital, Genoa, Italy. annalisapezzolo@ospedale-gaslini.ge.it
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pezzolo
authors.forename: Simona
authors.initials: S
authors.lastname: Coco
authors.forename: Alessandro
authors.initials: A
authors.lastname: Raso
authors.forename: Federica
authors.initials: F
authors.lastname: Parodi
authors.forename: Angela
authors.initials: A
authors.lastname: Pistorio
authors.forename: Francesca
authors.initials: F
authors.lastname: Valdora
authors.forename: Valeria
authors.initials: V
authors.lastname: Capra
authors.forename: Massimo
authors.initials: M
authors.lastname: Zollo
authors.forename: Simona
authors.initials: S
authors.lastname: Aschero
authors.forename: Eleonora
authors.initials: E
authors.lastname: Basso
authors.forename: Armando
authors.initials: A
authors.lastname: Cama
authors.forename: Paolo
authors.initials: P
authors.lastname: Nozza
authors.forename: Claudio
authors.initials: C
authors.lastname: Gambini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cinalli
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Garrè
authors.forename: Achille
authors.initials: A
authors.lastname: Iolascon
authors.forename: Vito
authors.initials: V
authors.lastname: Pistoia
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Tonini
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D055028:Comparative Genomic Hybridization; D006801:Humans; D007223:Infant; D019656:Loss of Heterozygosity; D008527:Medulloblastoma / Q000235:genetics* / Q000503:physiopathology; D015999:Multivariate Analysis; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor