title: Novel strategies for managing infantile hemangiomas: a review.
abstract: Complicated infantile hemangiomas require early intervention. With the advent of an improved understanding of the pathophysiology of the condition, and the serendipitous discovery of the effects of propranolol, available treatment options have expanded from the traditional use of steroids. This article reviews the current literature on the treatment of complicated hemangiomas with steroids, interferon, vincristine, bleomycin, and propranolol. The likely mechanism of action, indications, recommended treatment regimes, and complications are discussed.
authors.affiliation: Department of Burns & Plastic Surgery, Morriston Hospital, Swansea, UK.
authors.forename: Silvan
authors.initials: S
authors.lastname: Azzopardi
authors.forename: Thomas Christian
authors.initials: TC
authors.lastname: Wright
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001761:Bleomycin / Q000627:therapeutic use; D006391:Hemangioma / Q000188:drug therapy*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007223:Infant; D016898:Interferon-alpha / Q000627:therapeutic use; D011245:Pregnadienes / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D007155:Immunologic Factors; D016898:Interferon-alpha; D011245:Pregnadienes; D001761:Bleomycin; D014750:Vincristine; D011433:Propranolol