title: Severe canine influenza in dogs correlates with hyperchemokinemia and high viral load.
abstract: Canine influenza virus (CIV) is an emerging pathogen that causes acute respiratory disease in dogs. To better understand the mechanism(s) responsible for the virulence of the virus, we conducted immunological, virological, clinical, and histopathological analyses in CIV-infected dogs. CIV replicated efficiently in the respiratory system of dogs and caused severe respiratory disease. Notably, the infection induced the marked elevation and sustained expression of chemokines that resulted in severe bronchointerstitial pneumonia with extensive neutrophil infiltration. In clinicopathological findings, CIV infection resulted in regenerative anemia, perhaps due to pulmonary hemorrhage. The observations indicate that active replication of CIV in the canine respiratory system results in intense inflammatory responses central to the pathogenesis of H3N2 CIV.
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors.forename: Yu-Na
authors.initials: YN
authors.lastname: Lee
authors.forename: Hyun-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Dong-Hun
authors.initials: DH
authors.lastname: Lee
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Hee-Myung
authors.initials: HM
authors.lastname: Park
authors.forename: Sang-Soep
authors.initials: SS
authors.lastname: Nahm
authors.forename: Joong-Bok
authors.initials: JB
authors.lastname: Lee
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Park
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Choi
authors.forename: Chang-Seon
authors.initials: CS
authors.lastname: Song
mesh_terms: D000818:Animals; D018925:Chemokines / Q000097:blood* / Q000378:metabolism; D004283:Dog Diseases / Q000473:pathology / Q000821:virology*; D004285:Dogs; D053122:Influenza A Virus, H3N2 Subtype / Q000472:pathogenicity*; D009976:Orthomyxoviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D013997:Time Factors; D019562:Viral Load / Q000662:veterinary*; D014779:Virus Replication / Q000502:physiology
chemical_list: D018925:Chemokines