title: [Pelletization of melts and liquids].
abstract: During the second half of the last century, pelletization methods based on wetting were developed, e.g. agglomeration in coating pans, pelletization plates or fluid-bed equipment, layering of the drug in solution or suspension on inactive spherical cores, extrusion/spheronization and later on also rotoagglomeration in rotogranulators or rotoprocessors. These technologies have become a requisite part of industrial production of solid dosage forms. At present, numerous experimental papers deal with pellet preparation from melts and liquids. These new pelletization methods are the topic of the present article. Pellet preparation from melts is represented by three methods, i.e. fluid hot melt agglomeration, hot melt extrusion, and freeze pelletization. Jet cutting and cryopelletization are the techniques dealing with pellet preparation from liquids.
authors.affiliation: Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ustav technologie léků. rabiskovam@vfu.cz
authors.forename: Miloslava
authors.initials: M
authors.lastname: Rabisková
mesh_terms: D002626:Chemistry, Pharmaceutical; D010316:Particle Size; D013678:Technology, Pharmaceutical