title: C-Myb function in the vessel wall.
abstract: C-Myb is a DNA-binding transcription factor that functions in apoptosis, proliferation and differentiation. The role of c-Myb in vascular injury has been investigated previously both in vitro and in vivo, where knock-down of c-Myb is known to lead to a reduction in proliferation and an increase in apoptosis of vascular smooth muscle cells (VSMCs). Reduction of c-Myb activity has also been shown to decrease neointimal formation in vivo, by reducing VSMC proliferation. In contrast, over-expression of c-Myb in vivo leads to increased survival rates in certain cell types. This review will look mainly at studies investigating c-Myb function in the vasculature, and evidence of signalling interactions which may be considered with regard to c-Myb as a possible target in the treatment of vasculoproliferative diseases.
authors.affiliation: Core Technology Facility, University of Manchester, Manchester, UK.
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Farrell
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Withers
authors.forename: Cathy M
authors.initials: CM
authors.lastname: Holt
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006410:Hematopoiesis; D006801:Humans; D020598:Proto-Oncogene Proteins c-myb / Q000502:physiology*; D015398:Signal Transduction; D017539:Tunica Intima / Q000502:physiology*
chemical_list: D020598:Proto-Oncogene Proteins c-myb