title: Effect of enoxacin, felbinac, and sparfloxacin on fatty acid metabolism and glucose concentrations in rat tissues.
abstract: Multiple changes in metabolic levels could be useful for understanding physiological toxicity. To explore further risk factors for the convulsions induced by the interaction of nonsteroidal anti-inflammatory and new quinolone antimicrobial drugs, the effect of sparfloxacin, enoxacin, and felbinac on fatty acid metabolism and glucose concentrations in the liver, brain, and blood of rats was investigated. The levels of long-chain acyl-CoAs (C(18:1) and C(20:4)) in the liver and brain were decreased at the onset of convulsions induced by the coadministration of enoxacin with felbinac. Then, glucose concentrations in the liver and blood were decreased, whereas they were increased in a dose-dependant manner in the brain. However, the formation of acyl-CoAs and glucose levels in the liver, brain, and blood was not significantly influenced by enoxacin, felbinac, and sparfloxacin alone, respectively. The disturbance of both fatty acid metabolism and glucose levels might be associated with the increased susceptibility to convulsions, which may contribute to further understanding of the toxic effects associated with these drugs.
authors.affiliation: Biochemical Toxicology Laboratory, Faculty of Pharmaceutical Sciences, Kobegakuin University, 1-1-3, Minatojima, chuo-ku, Kobe, 651-2180, Japan. kasuya@pharm.kobegakuin.ac.jp
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Kasuya
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miwa
authors.forename: Maya
authors.initials: M
authors.lastname: Kazumi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inoue
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohta
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002853:Chromatography, Liquid; D015365:Enoxacin / Q000633:toxicity*; D005227:Fatty Acids / Q000378:metabolism*; D024841:Fluoroquinolones / Q000633:toxicity*; D005947:Glucose / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010648:Phenylacetates / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005227:Fatty Acids; D024841:Fluoroquinolones; D010648:Phenylacetates; D015365:Enoxacin; C012776:biphenylylacetic acid; D005947:Glucose; C061363:sparfloxacin