title: The role of hemoglobin variant replacement in retinopathy of prematurity.
abstract: OBJECTIVE
  To conduct tests of relationships between different factors that could influence the course of retinopathy of prematurity (ROP) and ROP, particularly the role of hemoglobin variant replacement in adult blood transfusions.
  
  
  METHODS
  A retrospective, observational study of 83 infants born between 23 and 34 wks gestation was conducted.
  
  
  RESULTS
  The infants without ROP, with 1 and 2 stage of ROP and with ≥ 3 stage of ROP received Q 28 (12-134); 51 (14-149); 156 (38-244) ml/kg of transfused blood, respectively, and the factor Qt was 1,545 (560-10,045); 3,093 (614-13,419); 11,907 (1,288-20,638) (ml/kg)·day, respectively. For the same groups MCV(35) (mean cell volume at the arbitrary time of the 35(th) wk post-conception) was 92.3 (82.9-110.5); 91.0 (79.3-101.4); 87.1 (80.2-94.8) fl, respectively, and factor P(MCV)/t was 99.5 (89.2-108.8); 96.3 (84.6-106.3); 90.7 (85.3-96.5) fl, respectively. There is high influence on the stage of ROP of the amount of transfused blood and MCV, both with or without the time factor. The statistical differences between P(MCV)/t were more significant than the differences between MCV(35), for different stages of ROP.
  
  
  CONCLUSIONS
  The influence of the time factor on the statistical differences of MCV but not on the amount of transfused adult blood suggests that HbF - HbA replacement may play a role in ROP development.
authors.affiliation: Department of Medical Physics, Pomeranian Medical University, ul. Ku Słońcu 12, 71-073, Szczecin, Poland. podrazaw@ams.edu.pl
authors.forename: Wojciech
authors.initials: W
authors.lastname: Podraza
authors.forename: Hanna
authors.initials: H
authors.lastname: Podraza
authors.forename: Karolina
authors.initials: K
authors.lastname: Jezierska
authors.forename: Joanna
authors.initials: J
authors.lastname: Szwed
authors.forename: Monika
authors.initials: M
authors.lastname: Modrzejewska
authors.forename: Jacek
authors.initials: J
authors.lastname: Rudnicki
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kordek
authors.forename: Hanna
authors.initials: H
authors.lastname: Domek
mesh_terms: D000328:Adult; D004909:Erythrocyte Indices; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008297:Male; D012178:Retinopathy of Prematurity / Q000097:blood / Q000209:etiology*; D012189:Retrospective Studies; D013997:Time Factors; D065227:Transfusion Reaction
chemical_list: D005319:Fetal Hemoglobin