title: Real-life driving outcomes in Parkinson disease.
abstract: OBJECTIVE
  To determine the incidence of and risk factors for driving outcomes in drivers with Parkinson disease (PD).
  
  
  METHODS
  In a prospective cohort study, we ascertained the time until driving cessation, a crash, or a traffic citation using self-report and state Department of Transportation records in 106 licensed, active drivers with PD and 130 controls.
  
  
  RESULTS
  Drivers with PD stopped driving earlier than controls, hazard ratio (95% confidence interval) = 7.09 (3.66-13.75), p < 0.001. Cumulative incidence of driving cessation at 2 years after baseline was 17.6% (11.5%-26.5%) for PD and 3.1% (1.2%-8.1%) for controls. No significant differences between groups on times to first crash or citation were detected. However, the number of observed crashes was low. Cox proportional hazards models showed that significant baseline risk factors for driving cessation in PD were older age, preference to be driven by somebody else, positive crash history, use of compensatory strategies, low driving exposure, impairments in visual perception (especially visual processing speed and attention) and cognitive abilities, parkinsonism (especially activities of daily living score and total daily dose of antiparkinsonian medications), and higher error counts on a road test. Within PD, crashes were associated with poorer postural stability and history of driving citations, and citations were associated with younger age and road errors at baseline.
  
  
  CONCLUSIONS
  Drivers with PD are at a higher risk of driving cessation than elderly control drivers. A battery evaluating motor and nonmotor aspects of PD, driving record, and performance can be useful in assessing future driving outcomes in PD.
authors.affiliation: Department of Neurology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA. ergun-uc@uiowa.edu
authors.forename: E Y
authors.initials: EY
authors.lastname: Uc
authors.forename: M
authors.initials: M
authors.lastname: Rizzo
authors.forename: A M
authors.initials: AM
authors.lastname: Johnson
authors.forename: J L
authors.initials: JL
authors.lastname: Emerson
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.forename: E D
authors.initials: ED
authors.lastname: Mills
authors.forename: S W
authors.initials: SW
authors.lastname: Anderson
authors.forename: J D
authors.initials: JD
authors.lastname: Dawson
mesh_terms: D000063:Accidents, Traffic / Q000706:statistics & numerical data*; D001334:Automobile Driving / Q000706:statistics & numerical data*; D006801:Humans; D010300:Parkinson Disease; D016016:Proportional Hazards Models