title: Maxillary sinus floor augmentation using a nano-crystalline hydroxyapatite silica gel: case series and 3-month preliminary histological results.
abstract: The aim of this case series is to histologically examine a new hydroxyapatite in sinus lift procedure after 3 months. Ten 2-stage sinus lifts were performed in 10 healthy patients having initial bone height of 1-2mm and bone width of 5mm, asking for a fixed implant-supported rehabilitation. After graft material augmentation, a rough-surfaced mini-implant was inserted to maintain stability of the sinus widow. A bioptical core containing a mini-implant was retrieved 3 months after maxillary sinus augmentation with NanoBone(®) and processed for undecalcified histology. From the histomorphometric analysis, NanoBone(®) residuals accounted for the 38.26% ± 8.07% of the bioptical volume, marrow spaces for the 29.23% ± 5.18% and bone for the 32.51% ± 4.96% (new bone: 20.64% ± 2.96%, native bone: 11.87% ± 3.27%). Well-mineralized regenerated bone with lamellar parallel-fibred structure and Haversian systems surrounded the residual NanoBone(®) particles. The measured bone-to-implant contact amounted to 26.02% ± 5.46%. No connective tissue was observed at the implant boundary surface. In conclusion, the tested material showed good histological outcomes also 3 months after surgery. In such critical conditions, the use of a rough-surfaced mini-implant showed BIC values supposed to be effective also in case of functional loading. Although longer follow-up and a wider patient size are needed, these preliminary results encourage further research on this biomaterial for implant load also under early stage and critical conditions.
authors.affiliation: luigicanullo@yahoo.com
authors.forename: Luigi
authors.initials: L
authors.lastname: Canullo
authors.forename: Claudia
authors.initials: C
authors.lastname: Dellavia
authors.forename: Friedhelm
authors.initials: F
authors.lastname: Heinemann
mesh_terms: D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D001853:Bone Marrow / Q000033:anatomy & histology / Q000254:growth & development; D018786:Bone Substitutes; D003758:Dental Implantation, Endosseous / Q000379:methods; D004338:Drug Combinations; D017886:Durapatite; D005260:Female; D006801:Humans; D008297:Male; D008437:Maxilla / Q000033:anatomy & histology; D008443:Maxillary Sinus / Q000033:anatomy & histology*; D019931:Maxillofacial Prosthesis Implantation; D008875:Middle Aged; D049329:Nanostructures; D011446:Prospective Studies; D058428:Silica Gel; D012822:Silicon Dioxide; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D004338:Drug Combinations; C534915:NanoBone; D058428:Silica Gel; D012822:Silicon Dioxide; D017886:Durapatite