title: Vascular calcification in chronic kidney disease: a changing scenario.
abstract: Vascular calcification (VC) is one of the most dramatic consequences of chronic kidney disease (CKD). It has been considered a passive process, resulting essentially from mineral metabolism disorders and alterations in calcium and phosphate balance. But during the last decade, it has been elucidated how VC is not only a passive but more properly an active process, in which different factors are deeply involved. The progression of vessel wall mineralization is commonly associated with factors that promote VC, such as age, dialysis vintage and mineral metabolism abnormalities. Furthermore, many substances seem to be dynamically implicated in the regulation of the molecular mechanisms of VC. Between them, the matrix Gla protein and fetuin-A have recently been investigated in CKD. In this review, along with the most promising possible treatments, the new molecular mechanisms involved in the VC process will be elucidated.
authors.affiliation: Department of Medicine, Surgery, and Dentistry, Renal Division, S. Paolo Hospital, University of Milan, Milan, Italy. mario.cozzolino@unimi.it
authors.forename: Mario
authors.initials: M
authors.lastname: Cozzolino
authors.forename: Irene
authors.initials: I
authors.lastname: Brenna
authors.forename: Paola
authors.initials: P
authors.lastname: Ciceri
authors.forename: Elisa
authors.initials: E
authors.lastname: Volpi
authors.forename: Daniele
authors.initials: D
authors.lastname: Cusi
authors.forename: Diego
authors.initials: D
authors.lastname: Brancaccio
mesh_terms: D001798:Blood Proteins / Q000502:physiology; D002114:Calcinosis / Q000503:physiopathology*; D002135:Calcium-Binding Proteins / Q000502:physiology; D002908:Chronic Disease; D018450:Disease Progression; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D008903:Minerals / Q000378:metabolism; D014652:Vascular Diseases / Q000503:physiopathology*; D060749:alpha-2-HS-Glycoprotein; D000097568:Matrix Gla Protein
chemical_list: D001798:Blood Proteins; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D008903:Minerals; D060749:alpha-2-HS-Glycoprotein; D000097568:Matrix Gla Protein; C556354:AHSG protein, human