title: Purpura fulminans caused by community-associated methicillin-resistant Staphylococcus aureus.
abstract: Sepsis-induced purpura fulminans is a rare but life-threatening condition characterized by rapidly progressive hemorrhagic infarction of the skin due to dermal vascular thrombosis resulting in tissue loss and severe scarring. Although most commonly related to meningococcal or invasive group A streptococcal disease, it may also be caused by several other bacterial or viral pathogens including Pneumococcus and Varicella. Purpura fulminans associated with Staphylococcus aureus sepsis is rare but has been reported in adults. However, the syndrome is very unusual in children, and to our knowledge, only 2 cases of staphylococcal purpura fulminans have been reported in children, both due to methicillin-susceptible S aureus in the United Kingdom. We report the first well-described case of purpura fulminans due to community-associated methicillin-resistant S aureus in a child.
authors.affiliation: Department of Surgery, Wake Forest University School of Medicine and Brenner Children's Hospital, Winston Salem, NC, USA.
authors.forename: Casimir J
authors.initials: CJ
authors.lastname: Fitzgerald
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Pranikoff
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Ross
authors.forename: Steven
authors.initials: S
authors.lastname: Mou
authors.forename: Laurence B
authors.initials: LB
authors.lastname: Givner
authors.forename: Avinash K
authors.initials: AK
authors.lastname: Shetty
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002675:Child, Preschool; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004636:Emergency Service, Hospital; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D055665:Purpura Fulminans / Q000209:etiology* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000150:complications* / Q000382:microbiology; D014640:Vancomycin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin; D014640:Vancomycin