title: Insertion/deletion polymorphism of the angiotensin-converting enzyme predicts left ventricular hypertrophy after renal transplantation.
abstract: BACKGROUND
  Kidney transplant recipients show a higher risk for cardiovascular complications, such as left ventricular hypertrophy and heart failure, leading to the premature death in many cases.
  
  
  METHODS
  We investigated the contribution of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism to the development of left ventricular hypertrophy (LVH), an indicator of heart disease progression among kidney transplant recipients.
  
  
  RESULTS
  We observed a significant correlation between graft function and left ventricular mass index. The occurrence of LVH or severe LVH was significantly greater among patients with at least one D-allele (ID or DD).
  
  
  CONCLUSIONS
  The use of ACE inhibitors or angiotensin receptor blockers seemed to be advantageous for patients with the ID and especially, the DD genotype.
authors.affiliation: University of Debrecen, Medical and Health Science Center, Division of Clinical Physiology, Debrecen, Hungary. f_roli@yahoo.com
authors.forename: R
authors.initials: R
authors.lastname: Fedor
authors.forename: L
authors.initials: L
authors.lastname: Asztalos
authors.forename: L
authors.initials: L
authors.lastname: Locsey
authors.forename: L
authors.initials: L
authors.lastname: Szabó
authors.forename: I S
authors.initials: IS
authors.lastname: Mányiné
authors.forename: M
authors.initials: M
authors.lastname: Fagyas
authors.forename: E
authors.initials: E
authors.lastname: Lizanecz
authors.forename: A
authors.initials: A
authors.lastname: Tóth
mesh_terms: D016009:Chi-Square Distribution; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D006814:Hungary; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000201:enzymology / Q000235:genetics*; D016030:Kidney Transplantation / Q000009:adverse effects*; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D017384:Sequence Deletion; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D007703:Peptidyl-Dipeptidase A