title: Semen and hormonal parameters in men with chronic hepatitis C infection.
abstract: Male patients with chronic hepatitis C virus (HCV) infection (n = 57) demonstrated a statistically significant decrease in semen volume, sperm count, and progressive sperm motility and a statistically significant increase in abnormal sperm morphology compared with healthy controls (n = 40). The duration of the HCV infection was negatively correlated with semen volume and sperm motility where the HCV RNA viral load was negatively correlated with sperm count and sperm motility. Chronic HCV patients had statistically significantly lower total serum testosterone and higher serum E(2) and prolactin levels compared with healthy controls.
authors.affiliation: Dermatology and Andrology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
authors.forename: Eman Riaad M
authors.initials: ER
authors.lastname: Hofny
authors.forename: Mohammed Essam M
authors.initials: ME
authors.lastname: Ali
authors.forename: Emad A
authors.initials: EA
authors.lastname: Taha
authors.forename: Hanan M
authors.initials: HM
authors.lastname: Nafeh
authors.forename: Doaa Samir
authors.initials: DS
authors.lastname: Sayed
authors.forename: Hanan G
authors.initials: HG
authors.lastname: Abdel-Azeem
authors.forename: Ehab Fawzy
authors.initials: EF
authors.lastname: Abdou
authors.forename: Ghada Mostafa
authors.initials: GM
authors.lastname: Kamal
authors.forename: Taymour
authors.initials: T
authors.lastname: Mostafa
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004534:Egypt; D004958:Estradiol / Q000097:blood; D005298:Fertility; D016174:Hepacivirus / Q000235:genetics / Q000472:pathogenicity*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006728:Hormones / Q000097:blood*; D006801:Humans; D007248:Infertility, Male / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000821:virology*; D008297:Male; D011388:Prolactin / Q000097:blood; D012367:RNA, Viral / Q000097:blood; D013076:Sperm Count; D013081:Sperm Motility; D013091:Spermatogenesis; D013094:Spermatozoa / Q000473:pathology / Q000821:virology*; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D019562:Viral Load
chemical_list: D015415:Biomarkers; D006728:Hormones; D012367:RNA, Viral; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin