title: Renal function, renal volume, and blood pressure in infants with antecedent of antenatal steroids.
abstract: Steroids have been used for more than 20 years in preterm infants to induce pulmonary maturity; however, some long-term effects have been reported, such as insulin resistance and elevation of blood pressure. The aim of our study was to compare renal volume, renal function, and blood pressure in infants between 12-36 months of age with and without antecedent of antenatal steroid treatment. This was a cross-sectional study comprised of three groups of infants (n = 30, respectively): preterm infants with and without antecedent of receiving antenatal steroids, respectively, and full-term infants. Blood pressure, renal volume, glomerular filtration rate, and tubular function were measured. Blood pressure and cystatin C levels and glomerular filtration rate were higher in both groups of preterm infants than in the control group (p < 0.01). However, no difference in any of the tested variables between the steroid and non-steroid group of preterm infants. Renal volume was similar in preterm and control infants. Based on these results, we conclude that prematurity independent of antenatal steroid use is associated with higher cystatin C and blood pressure levels and a higher glomerular filtration rate in infants between 12-36 months of age.
authors.affiliation: Unidad Médica de Alta Especialidad No. 48, Instituto Mexicano del Seguro Social, Leon, Guanajuato, Mexico.
authors.forename: Deyanira
authors.initials: D
authors.lastname: Carballo-Magdaleno
authors.forename: Juan M
authors.initials: JM
authors.lastname: Guízar-Mendoza
authors.forename: Norma
authors.initials: N
authors.lastname: Amador-Licona
authors.forename: Víctor
authors.initials: V
authors.lastname: Domínguez-Domínguez
mesh_terms: D001724:Birth Weight; D001794:Blood Pressure / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects; D002675:Child, Preschool; D055316:Cystatin C / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007668:Kidney / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology*; D007677:Kidney Function Tests; D008297:Male; D011295:Prenatal Care; D011446:Prospective Studies; D012737:Sex Factors; D013256:Steroids / Q000009:adverse effects* / Q000627:therapeutic use; D014463:Ultrasonography; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D055316:Cystatin C; D013256:Steroids; D001613:beta 2-Microglobulin