title: Physico-chemical characterization of γ-amino n-butyric acid nanoparticles.
abstract: This work deals with the preparation and characterization of high-purity nanoparticles of γ-amino n-butyric acid (GABA) in order to enhance the efficiency of this drug. A sublimation procedure at low pressure was applied to GABA after improving the experimental parameters of this physical transformation. The elaboration of the molecule is solvent-free. The process does not change the chemical formula of the compound but modifies its physico-chemical characteristics. In this work, we present the experimental parameters for preparing monoclinic GABA nanoparticles. Their identification and physico-chemical properties were determined with a large number of investigations: Powder X-ray diffraction (PXRD), density and purity measurements, differential scanning calorimetry (DSC), thermo-gravimetric analysis (TGA), calorimetric measurements (ΔH(dissolution) and C(p)), thermally stimulated current (TSC), and electrochemical impedance.
authors.affiliation: Matériaux et Santé, EA 401 Faculté de Pharmacie, Université Paris-Sud, 5 rue J. B. Clément, Châtenay-Malabry, France. emma.dichi@u-psud.fr
authors.forename: Emma
authors.initials: E
authors.lastname: Dichi
authors.forename: Mehrez
authors.initials: M
authors.lastname: Sghaier
authors.forename: Bernard
authors.initials: B
authors.lastname: Fraisse
authors.forename: François
authors.initials: F
authors.lastname: Bonhomme
mesh_terms: D002152:Calorimetry, Differential Scanning; D058266:Dielectric Spectroscopy; D053758:Nanoparticles / Q000737:chemistry*; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D005680:gamma-Aminobutyric Acid / Q000737:chemistry*
chemical_list: D005680:gamma-Aminobutyric Acid