title: Acquisition of sexual receptivity: roles of chromatin acetylation, estrogen receptor-alpha, and ovarian hormones.
abstract: Sexually naïve, hormone-primed, C57BL/6J female mice are not receptive to mating attempts by conspecific males. Repeated experience with sexually active males and concurrent treatment with estradiol and progesterone gradually increases female receptivity over the course of five trials to maximal levels. Ovarian hormones activate their cognate nuclear steroid receptors estrogen receptor-α and progesterone receptor to induce female sexual receptivity. Nuclear receptors recruit coactivators of transcription that include histone acetyltransferases to hormone responsive genes. In this set of studies, we found that the histone deacetylase inhibitor sodium butyrate enhances the experiential acquisition of receptivity. Evidence is provided that the actions of sodium butyrate on receptivity require activated estrogen receptor-α and progesterone.
authors.affiliation: Department of Biochemistry and Molecular Genetics and Neuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Bonthuis
authors.forename: James K
authors.initials: JK
authors.lastname: Patteson
authors.forename: Emilie F
authors.initials: EF
authors.lastname: Rissman
mesh_terms: D000107:Acetylation; D000818:Animals; D002087:Butyrates / Q000494:pharmacology; D002843:Chromatin / Q000378:metabolism*; D047628:Estrogen Receptor alpha / Q000502:physiology*; D005260:Female; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006657:Histones / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D011374:Progesterone / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000187:drug effects
chemical_list: D002087:Butyrates; D002843:Chromatin; D047628:Estrogen Receptor alpha; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D011374:Progesterone