title: Efficient synthesis of unnatural dipeptides based on cis-2,5-disubstituted pyrrolidine.
abstract: The well-defined unnatural dipeptides based on cis-2,5-disubstituted pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(-)-1-phenylethylamine, and phenylalanine. The configurations of all the chiral centers in these unnatural dipeptides are confirmed by X-ray crystal diffraction analysis.
authors.affiliation: Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Changle Xilu 17, Xi'an, 710032, People's Republic of China. ping_an1718@yahoo.com.cn
authors.forename: Ping-An
authors.initials: PA
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Si-Kun
authors.initials: SK
authors.lastname: Cheng
authors.forename: Sheng-Yong
authors.initials: SY
authors.lastname: Zhang
mesh_terms: D000272:Adipates / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004151:Dipeptides / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010627:Phenethylamines / Q000737:chemistry*; D010649:Phenylalanine / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000272:Adipates; D004151:Dipeptides; D010627:Phenethylamines; D011759:Pyrrolidines; D010649:Phenylalanine