title: Genetic susceptibility to lung cancer.
abstract: Lung cancer is a highly environmental disease, but cancer researchers have long been interested in investigating genetic susceptibility to lung cancer. This paper is a historical review and provides updated perspectives on lung cancer susceptibility research. The recent introduction of easier genotyping methods and the availability of an almost complete human genome database facilitated the association study to thousands of cases and controls for millions of genetic markers. Discoveries in the field of behavior genetics, that is, the genetic aspects of smoking behavior and nicotine addiction, unexpectedly indicated that polymorphisms in the human central nervous system play an important role in eventually leading to lung cancer. These findings were achieved by using comprehensive approaches, such as a genome, transcriptome, or proteome approach, and the studies were often conducted without a hypothesis. Another-omics approach, the "adductome" or "exposome" approach to how life style information can be integrated into the framework of genetic association studies, has recently emerged. These new paradigms will influence the area of lung cancer risk evaluation in genome cohort studies.
authors.affiliation: Department of Pathology, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Shizuoka, Japan. hsugimur@hama-med.ac.jp
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sugimura
authors.forename: Hong
authors.initials: H
authors.lastname: Tao
authors.forename: Masaya
authors.initials: M
authors.lastname: Suzuki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Mori
authors.forename: Masaru
authors.initials: M
authors.lastname: Tsuboi
authors.forename: Shun
authors.initials: S
authors.lastname: Matsuura
authors.forename: Masanori
authors.initials: M
authors.lastname: Goto
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shinmura
authors.forename: Takachika
authors.initials: T
authors.lastname: Ozawa
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Tanioka
authors.forename: Naomi
authors.initials: N
authors.lastname: Sato
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Matsushima
authors.forename: Shinji
authors.initials: S
authors.lastname: Kageyama
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Funai
authors.forename: Pei-Hsin
authors.initials: PH
authors.lastname: Chou
authors.forename: Tomonari
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods / Q000639:trends*; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics; D011110:Polymorphism, Genetic; D012907:Smoking / Q000009:adverse effects*
chemical_list: D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase