title: The role of nuclear factor κB in the interferon response.
abstract: The nuclear factor κB (NF-κB) transcription factor regulates the expression of genes involved in cell survival and immune responses. We have identified a novel interferon (IFN)-activated signaling pathway that leads to NF-κB activation and demonstrate that a subset of IFN-stimulated genes and microRNAs that play key roles in cellular response to IFN is regulated by NF-κB. This review focuses on the IFN-induced NF-κB activation pathway and the role of NF-κB in the expression of IFN-induced coding and noncoding genes, antiviral activity and apoptosis, and the therapeutic application of IFN in cancer and infectious disease.
authors.affiliation: Department of Pathology and Laboratory Medicine and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA. lpfeffer@uthsc.edu
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Pfeffer
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D001424:Bacterial Infections / Q000188:drug therapy* / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007372:Interferons / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D015533:Transcriptional Activation / Q000276:immunology; D014777:Virus Diseases / Q000188:drug therapy* / Q000276:immunology
chemical_list: D016328:NF-kappa B; D007372:Interferons