title: Acoschimperoside P, 2'-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra.
abstract: Complete (1)H and (13)C NMR assignments of acoschimperoside P, 2'-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
authors.forename: Yusnita
authors.initials: Y
authors.lastname: Rifai
authors.forename: Midori A
authors.initials: MA
authors.lastname: Arai
authors.forename: Takashi
authors.initials: T
authors.lastname: Koyano
authors.forename: Thaworn
authors.initials: T
authors.lastname: Kowithayakorn
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D029062:Apocynaceae / Q000737:chemistry*; D015153:Blotting, Western; D002301:Cardiac Glycosides / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure
chemical_list: D002301:Cardiac Glycosides; D006027:Glycosides