title: Experimental designs and their recent advances in set-up, data interpretation, and analytical applications.
abstract: In this review, the set-up and data interpretation of experimental designs (screening, response surface, and mixture designs) are discussed. Advanced set-ups considered are the application of D-optimal and supersaturated designs as screening designs. Advanced data interpretation approaches discussed are an adaptation of the algorithm of Dong and the estimation of factor effects from supersaturated design results. Finally, some analytical applications in separation science, on the one hand, and formulation-, product-, or process optimization, on the other, are discussed.
authors.affiliation: Department of Analytical Chemistry and Pharmaceutical Technology (FABI), Center for Pharmaceutical Research (CePhaR), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium.
authors.forename: Bieke
authors.initials: B
authors.lastname: Dejaegher
authors.forename: Yvan Vander
authors.initials: YV
authors.lastname: Heyden
mesh_terms: D000465:Algorithms; D002626:Chemistry, Pharmaceutical; D003627:Data Interpretation, Statistical; D004339:Drug Compounding; D004340:Drug Contamination / Q000517:prevention & control; D005163:Factor Analysis, Statistical; D057166:High-Throughput Screening Assays / Q000706:statistics & numerical data; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000032:analysis; D012107:Research Design / Q000706:statistics & numerical data; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D004364:Pharmaceutical Preparations