title: Alternative splicing of RAGE: roles in biology and disease.
abstract: The Receptor for Advanced Glycation End-products (RAGE) is a complex, multi-ligand signaling system implicated in the pathogenesis of diabetes, cardiovascular disease and various cancers. RAGE undergoes extensive alternative splicing to produce a variety of transcripts with diverse functions, including soluble antagonists and variants with altered ligand binding domains. Studies focused on the major soluble variant (RAGEv1/esRAGE) have revealed this to function by binding RAGE-ligands and preventing activation of RAGE signaling in vascular and tumor cells. Furthermore, measurement of this variant in human serum has revealed that RAGEv1/esRAGE levels may represent a novel biomarker for RAGE-ligand related pathogenic states. Understanding the full plethora of RAGE alternative splicing and its regulation is central to elucidating the role of RAGE in biology and disease.
authors.affiliation: Division of Nephrology/Hypertension, Feinberg School of Medicine, Northwestern University, IL, USA.
authors.forename: Anastasia Z
authors.initials: AZ
authors.lastname: Kalea
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Schmidt
authors.forename: Barry I
authors.initials: BI
authors.lastname: Hudson
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D011401:Promoter Regions, Genetic; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000235:genetics; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D008024:Ligands; D012333:RNA, Messenger; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic