title: Hyperbranched polymers versus dendrimers containing a carbosilane framework and terminal ammonium groups as antimicrobial agents.
abstract: A new family of amine- and ammonium-terminated hyperbranched polycarbosilanes (PCS) and dendrimers has been synthesized. The functionalization of a polycarbosilane matrix was carried out with peripheral allyl groups by two strategies in the case of PCS: 1) hydrosilylation of allyl amines with PCS containing terminal Si-H bonds, or 2) hydrosilylation of PCS-allyl with an aminosilane. Dendrimers with terminal amine groups were synthesized by hydrosilylation of allydimethylamine. Quaternized systems with MeI are soluble and stable in water or other protic solvent. The antibacterial properties of the ammonium-terminated hyperbranched polycarbosilanes and dendrimers have been evaluated showing that they act as potent biocides against Gram-positive and Gram-negative bacterial strains.
authors.affiliation: Departamento de Química Inorgánica, Universidad de Alcalá, Campus Universitario, Edificio de Farmacia, E-28871, Alcalá de Henares, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Ortega
authors.forename: Beatriz
authors.initials: B
authors.lastname: Macarena Cobaleda
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Hernández-Ros
authors.forename: Elena
authors.initials: E
authors.lastname: Fuentes-Paniagua
authors.forename: Javier
authors.initials: J
authors.lastname: Sánchez-Nieves
authors.forename: Ma Pilar
authors.initials: MP
authors.lastname: Tarazona
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Copa-Patiño
authors.forename: Juan
authors.initials: J
authors.lastname: Soliveri
authors.forename: Fco Javier
authors.initials: FJ
authors.lastname: de la Mata
authors.forename: Rafael
authors.initials: R
authors.lastname: Gómez
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D050091:Dendrimers; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D012821:Silanes