title: Effects of aluminum exposure on the adherence, chemotaxis, and phagocytosis capacity of peritoneal macrophages in rats.
abstract: To investigate the effects of aluminum (Al) exposure on peritoneal macrophages of Wistar rats, four groups of ten rats each were orally exposed to 0, 13, 26, and 52 mg kg(-1) Al(3+) in form of aluminum trichloride (AlCl(3)) in drinking water for 120 days. At the end of the experimental period, the Al concentration in serum, the adherence, chemotaxis, and phagocytosis capacity of peritoneal macrophages were determined. The results showed that the Al concentration in serum significantly increased in a dose-dependent manner; the adherence, chemotaxis, and phagocytosis capacity of peritoneal macrophages decreased with the increase of Al dose, and present a dose-effective relationship. Further, they were significantly lower in the high-dose groups (P < 0.01) compared with the control group. It indicates that Al was toxic to peritoneal macrophages of rats, and the adherence, chemotaxis, and phagocytosis capacity of peritoneal macrophages in rats were significantly suppressed by exposure to 52 mg kg(-1) day Al(3+).
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Chongwei
authors.initials: C
authors.lastname: Hu
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Yanzhu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Hansong
authors.initials: H
authors.lastname: Zhao
authors.forename: Bing
authors.initials: B
authors.lastname: Shao
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Li
mesh_terms: D000535:Aluminum / Q000097:blood / Q000633:toxicity*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000633:toxicity; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D002712:Chlorides / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D008297:Male; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D000535:Aluminum