title: Association between fibroblast growth factor receptor-4 gene polymorphism and risk of prostate cancer: a meta-analysis.
abstract: OBJECTIVE
  To examine the association between fibroblast growth factor receptor-4 (FGFR-4) genetic polymorphisms (Gly-388Arg) and prostate cancer susceptibility.
  
  
  METHODS
  A comprehensive search was conducted to identify all case-control studies of FGFR-4 polymorphisms and prostate cancer risk. Statistical analysis was performed with the software program Stata, version 8.0, and Review Manage, version 4.2.
  
  
  RESULTS
  A total of 4 eligible studies, including 2,618 cases and 2,305 controls, relating the FGFR-4 polymorphism to the risk of prostate cancer were identified. The overall results indicated a significant association between FGFR-4 polymorphisms and prostate cancer. In the subgroup analysis by ethnicity, a significant association was found between European descent for recessive model (random effects OR 0.82, 95% CI 0.72-0.93) and co-dominant genetic model (random effects OR 0.83, 95% CI 0.68-1.00). Sensitivity analysis also found a significant association in the recessive (random effects OR 0.68, 95% CI 0.49-0.95) or the co-dominant (random effects OR 0.68, 95% CI 0.49-0.96) models. Egger's test showed that publication bias was not present in any of the comparisons.
  
  
  CONCLUSIONS
  Gly-388Arg polymorphism of FGFR-4 most likely contributes to susceptibility to prostate cancer, especially in men of European descent.
authors.affiliation: Tianjin Institute of Urology, Tianjin Medical University, Tianjin, PR China.
authors.forename: Liu
authors.initials: L
authors.lastname: Liwei
authors.forename: Liu
authors.initials: L
authors.lastname: Chunyu
authors.forename: Li
authors.initials: L
authors.lastname: Jie
authors.forename: Han
authors.initials: H
authors.lastname: Ruifa
mesh_terms: D000483:Alleles; D005060:Europe; D015972:Gene Expression Regulation, Neoplastic; D005799:Genes, Dominant; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism*; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000235:genetics* / Q000378:metabolism*; D012306:Risk; D012680:Sensitivity and Specificity
chemical_list: D051499:Receptor, Fibroblast Growth Factor, Type 4