title: Synchronous second primary neoplasms detected by initial staging F-18 FDG PET/CT examination in patients with non-Hodgkin lymphoma.
abstract: OBJECTIVE
  Cases of synchronous non-Hodgkin lymphoma (NHL) and second primary carcinoma in previously untreated immunocompetent patients are relatively rare. The aim of this part of our prospective study was to a revealed 2-F-18 fluoro-2-deoxy-D-glucose (F-18 FDG) positron emission tomography (PET)-positive lesion in an extranodal organ suggestive of second primary neoplasm in newly diagnosed NHL patients.
  
  
  METHODS
  A total of 209 patients with NHL underwent initial staging F-18 FDG PET/computed tomography (CT). The finding was assessed by a radiologist, nuclear medicine physician, and hematologist. In 6 suspicious cases (2.9%) of second neoplasm, the decision was made to perform further investigations before lymphoma therapy.
  
  
  RESULTS
  Two patients were diagnosed with colorectal carcinoma, 1 with esophageal adenocarcinoma, 1 with invasive ductal breast carcinoma, 1 with medullary thyroid carcinoma, and 1 with squamous cell lung carcinoma. In 5 of the 6 patients, the second solid tumor was completely asymptomatic and revealed only by F-18 FDG PET/CT examination.
  
  
  CONCLUSIONS
  We conclude that in patients with NHL, appropriate imaging, clinical, and histologic analysis of organ lesions detected by F-18 FDG PET/CT will occasionally demonstrate significant synchronous neoplasms.
authors.affiliation: Department of Hemato-Oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic. tomas.papajik@fnol.cz
authors.forename: Tomáš
authors.initials: T
authors.lastname: Papajík
authors.forename: Miroslav
authors.initials: M
authors.lastname: Mysliveček
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Sedová
authors.forename: Eva
authors.initials: E
authors.lastname: Buriánková
authors.forename: Vít
authors.initials: V
authors.lastname: Procházka
authors.forename: Luděk
authors.initials: L
authors.lastname: Raida
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Kubová
authors.forename: Cestmír
authors.initials: C
authors.lastname: Neoral
authors.forename: David
authors.initials: D
authors.lastname: Starostka
authors.forename: Petr
authors.initials: P
authors.lastname: Mikula
authors.forename: Bohuslav
authors.initials: B
authors.lastname: Melichar
authors.forename: Ladislava
authors.initials: L
authors.lastname: Kučerová
authors.forename: Martin
authors.initials: M
authors.lastname: Tichý
authors.forename: Karel
authors.initials: K
authors.lastname: Indrák
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18