title: Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.
abstract: We investigated a relationship between selected polymorphisms: rs6313 in HTR2A, rs6295 in HTR1A and rs1386494 in TPH2, and suicidal behaviour in 150 alcohol-dependent patients. There was a significant association between more frequent C102C genotype in HTR2A and suicide attempts in alcoholic females. No differences in genotype distribution in HTR1A and TPH2 SNPs were found between patients with and without suicide attempts.
authors.affiliation: Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wrzosek
authors.forename: Jacek
authors.initials: J
authors.lastname: Łukaszkiewicz
authors.forename: Michał
authors.initials: M
authors.lastname: Wrzosek
authors.forename: Piotr
authors.initials: P
authors.lastname: Serafin
authors.forename: Andrzej
authors.initials: A
authors.lastname: Jakubczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Klimkiewicz
authors.forename: Halina
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Kirk J
authors.initials: KJ
authors.lastname: Brower
authors.forename: Marcin
authors.initials: M
authors.lastname: Wojnar
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013406:Suicide, Attempted; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D055815:Young Adult
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D044282:Receptor, Serotonin, 5-HT1A; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase