title: Vacuolar H(+)-ATPases: intra- and intermolecular interactions.
abstract: V-ATPases in eukaryotes are heteromultimeric, H(+)-transporting proteins. They are localized in a multitude of different membranes and energize many different transport processes. Unique features of V-ATPases are, on the one hand, their ability to regulate enzymatic and ion transporting activity by the reversible dissociation of the catalytic V(1) complex from the membrane bound proton translocating V(0) complex and, on the other hand, their high sensitivity to specific macrolides such as bafilomycin and concanamycin from streptomycetes or archazolid and apicularen from myxomycetes. Both features require distinct intramolecular as well as intermolecular interactions. Here we will summarize our own results together with newer developments in both of these research areas.
authors.affiliation: University of Osnabrück, Faculty of Biology and Chemistry, Department of Animal Physiology, Barbarastrasse 11, 49076 Osnabrück, Germany. huss@biologie.uni-osnabrueck.de
authors.forename: Markus
authors.initials: M
authors.lastname: Huss
authors.forename: Olga
authors.initials: O
authors.lastname: Vitavska
authors.forename: Andrea
authors.initials: A
authors.lastname: Albertmelcher
authors.forename: Svenja
authors.initials: S
authors.lastname: Bockelmann
authors.forename: Christin
authors.initials: C
authors.lastname: Nardmann
authors.forename: Katharina
authors.initials: K
authors.lastname: Tabke
authors.forename: Felix
authors.initials: F
authors.lastname: Tiburcy
authors.forename: Helmut
authors.initials: H
authors.lastname: Wieczorek
mesh_terms: D006801:Humans; D011485:Protein Binding; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism*; D014617:Vacuoles / Q000201:enzymology
chemical_list: D025262:Vacuolar Proton-Translocating ATPases