title: Computer-Aided Grading of Lymphangioleiomyomatosis (LAM) using HRCT.
abstract: Lymphangioleiomyomatosis (LAM) is a multisystem disorder associated with proliferation of smooth muscle-like cells, which leads to destruction of lung parenchyma. Subjective grading of LAM on HRCT is imprecise and can be arduous especially in cases with severe involvement. We propose a computer-aided evaluation system that grades LAM involvement based on analysis of lung texture patterns. A committee of support vector machines is employed for classification. The system was tested on 36 patients. The computer grade demonstrates good correlation with subjective radiologist grade (R=0.91, p<0.0001) and pulmonary functional tests (R=0.85, p<0.0001). The grade also provides precise progression assessment of disease over time.
authors.affiliation: Diagnostic Radiology Department, Clinical Center, National Institute of Health, Bethesda, MD, USA.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yao
authors.forename: Nilo
authors.initials: N
authors.lastname: Avila
authors.forename: Andrew
authors.initials: A
authors.lastname: Dwyer
authors.forename: Angelo M
authors.initials: AM
authors.lastname: Taveira-Dasilva
authors.forename: Olanda M
authors.initials: OM
authors.lastname: Hathaway
authors.forename: Joel
authors.initials: J
authors.lastname: Moss