title: Amyloid beta 1-42 in cerebrospinal fluid is associated with cognitive plasticity.
abstract: Cerebrospinal fluid (CSF) total tau-protein (t-tau) and amyloid-beta 1-42 (Abeta(1-42)) have been increasingly included in the diagnostic process of Alzheimer's disease (AD). We aimed to analyze whether these CSF biomarkers correlate with cognitive plasticity as measured by a dynamic recognition test strategy. We assessed 29 elderly individuals (15 with incipient and 14 without AD) from an outpatient memory clinic at a university hospital by a Testing-the-Limits (TtL) based recognition paradigm consisting of a pre-test (baseline) and two post-test conditions with an interposed encoding instruction. We identified a negative association between Abeta(1-42) and the two post-test failure rates, but not with that of the pre-test. Also, none of the standard tests correlates with Abeta 42-1 level. T-tau does not correlate with recognition performance. Our results suggest that Abeta(1-42) could be useful as a state marker for cognitive plasticity.
authors.affiliation: Neurologische Klinik der Universität Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany. ingo.uttner@uni-ulm.de
authors.forename: Ingo
authors.initials: I
authors.lastname: Uttner
authors.forename: Niklas
authors.initials: N
authors.lastname: Schurig
authors.forename: Christine A F
authors.initials: CA
authors.lastname: von Arnim
authors.forename: Christian
authors.initials: C
authors.lastname: Lange-Asschenfeldt
authors.forename: Johannes
authors.initials: J
authors.lastname: Brettschneider
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Riepe
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Tumani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000150:complications; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D018709:Statistics, Nonparametric; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins