title: Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives.
abstract: In the present study two series of novel imidazole derivatives containing substituted pyrazole moiety (3a-d and 5a-j) were synthesized. The first series were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazones (2a-d) with DMAD and the second series by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes (1a-e) with 1,2-diketones (4a,b) in the presence of ammonium acetate. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for antifungal and antibacterial activities. Among the synthesized compounds, compound 3c was found to be potent antimicrobial agent. The acute oral toxicity study for the compound 3c was carried out and the experimental studies revealed that compound 3c is safe up to 3000 mg/kg and no death of animals were recorded.
authors.affiliation: SeQuent Scientific Ltd., No. 120 A & B, Industrial Area, Baikampady, New Mangalore 575 011, Karnataka, India.
authors.forename: A M
authors.initials: AM
authors.lastname: Vijesh
authors.forename: Arun M
authors.initials: AM
authors.lastname: Isloor
authors.forename: Sandeep
authors.initials: S
authors.lastname: Telkar
authors.forename: S K
authors.initials: SK
authors.lastname: Peethambar
authors.forename: Sankappa
authors.initials: S
authors.lastname: Rai
authors.forename: Nishitha
authors.initials: N
authors.lastname: Isloor
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D020714:Maximum Tolerated Dose; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D007093:Imidazoles; D011720:Pyrazoles; C031280:pyrazole