title: Chemical constituents from the roots of Feroniella lucida.
abstract: A new furanocoumarin named lucidafuranocoumarin A (7) together with 13 known coumarins (1-6, 8-14) and four known alkaloids (15-18) was isolated from the roots of Feroniella lucida. Their structures were elucidated on the basis of spectroscopic analysis. Some of the isolates were evaluated for their biological activities, and compound 18 showed strong cytotoxicity against KB (IC(50) = 0.637 μg/ml) and NCI-H187 (IC(50) = 0.094 μg/ml) human cancer cell lines, antimalarial activity against Plasmodium falciparum (IC(50) = 0.336 μg/ml), and antituberculosis activity against Mycobacterium tuberculosis (MIC = 6.25 μg/ml).
authors.affiliation: Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Chiang Rai, Thailand.
authors.forename: Tawanun
authors.initials: T
authors.lastname: Sripisut
authors.forename: Sarot
authors.initials: S
authors.lastname: Cheenpracha
authors.forename: Surat
authors.initials: S
authors.lastname: Laphookhieo
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D000995:Antitubercular Agents; D003374:Coumarins; D005663:Furans; C560721:lucidafuranocoumarin A