title: Normal adrenal function in an infant following a pregnancy complicated by maternal adrenal cortical carcinoma and mitotane exposure.
abstract: Maternal adrenal cortical carcinoma in pregnancy is rare. We report a case of an infant born to a mother with a history of adrenal cortical carcinoma. The pregnancy was complicated by fetal exposure to mitotane and dexamethasone. Despite the potential teratogenic exposures, there was no evidence of adrenal dysfunction in the infant. Growth and development at 12 months of age are normal and prognosis appears favorable. The long-term impact of fetal exposure to mitotane and glucocorticoid requires further investigation.
authors.affiliation: Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Kojori
authors.forename: Catherine M G
authors.initials: CM
authors.lastname: Cronin
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Salamon
authors.forename: Craig
authors.initials: C
authors.lastname: Burym
authors.forename: Elizabeth Ann Cameron
authors.initials: EA
authors.lastname: Sellers
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy*; D000311:Adrenal Glands / Q000187:drug effects* / Q000196:embryology / Q000502:physiology; D018268:Adrenocortical Carcinoma / Q000188:drug therapy*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D018811:Maternal Exposure; D008939:Mitotane / Q000627:therapeutic use*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane; D003907:Dexamethasone