title: Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis.
abstract: Markedly inhibitory effects of hybrid liposomes (HL-n) composed of 90 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of adult T-cell leukemia cells were obtained for the first time. It is noteworthy that HL-n could selectively accumulate into the adult T-cell leukemia cells and induce apoptosis via caspase-3 activation.
authors.affiliation: Division of Applied Life Science, Graduate School of Engineering, Sojo University, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Komizu
authors.forename: Mamiko
authors.initials: M
authors.lastname: Yukihara
authors.forename: Ryusho
authors.initials: R
authors.lastname: Kariya
authors.forename: Koichi
authors.initials: K
authors.lastname: Goto
authors.forename: Seiji
authors.initials: S
authors.lastname: Okada
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ueoka
mesh_terms: D017209:Apoptosis; D002330:Carmustine / Q000008:administration & dosage; D002478:Cells, Cultured; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D016503:Drug Delivery Systems; D006601:Hexoses / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D015459:Leukemia-Lymphoma, Adult T-Cell; D008081:Liposomes / Q000008:administration & dosage* / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry
chemical_list: D006601:Hexoses; D008081:Liposomes; D011136:Polysorbates; C014822:sorbitan monolaurate; D002330:Carmustine; D004134:Dimyristoylphosphatidylcholine