title: FeCl3-mediated synthesis of polysubstituted tetrahydroquinolines via domino Mannich/Friedel-Crafts reactions of aldehydes and amines.
abstract: A useful method to construct highly substituted tetrahydroquinolines has been developed through an iron(III) chloride-mediated domino Mannich and intramolecular Friedel-Crafts alkylation followed by intermolecular Friedel-Crafts alkylation reactions of aliphatic aldehydes with aromatic amines.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, People's Republic of China.
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Yang
authors.forename: Xing-Zhong
authors.initials: XZ
authors.lastname: Shu
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Wei
authors.forename: Jian-Yi
authors.initials: JY
authors.lastname: Luo
authors.forename: Shaukat
authors.initials: S
authors.lastname: Ali
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000588:Amines; D002712:Chlorides; D005290:Ferric Compounds; D011804:Quinolines; C542964:1,2,3,4-tetrahydroquinoline; C024555:ferric chloride