title: [Clinical study on simvastatin treatment of pulmonary hypertension in patients with coal worker's pneumoconiosis].
abstract: OBJECTIVE
  To observe simvastatin treatment of pulmonary hypertension in patients with coal workers pneumoconiosis (CWP).
  
  
  METHODS
  96 CWP patients with pulmonary hypertension were randomly divided into treatment and control groups. The control group was treated with 2.5 mg warfarin, once a day for four months; the treatment group was treated with 20 mg simvastatin, taken in evening, for 4 months. 6 min walking distance (6MWD) test and inspection pulmonary artery pressure were measured by echocardiography before and after treatment.
  
  
  RESULTS
  In the treatment group, the 6MWD were (258 ± 26) m after treatment and (225 ± 19) m before treatment, respectively. Compared with control group, pulmonary artery pressure was (41 ± 9) mm Hg in the treatment group before treatment, (36 ± 3) mm Hg in the treatment group after treatment, and (39 ± 5) mm Hg in control group, respectively, the difference was statistically significant (P < 0.05).
  
  
  CONCLUSIONS
  Simvastatin can improve pulmonary hypertension in coal workers pneumoconiosis, and shows a definite curative effect.
authors.affiliation: Huaibei Mining Group Occupational Disease Prevention Hospital Dust in Four Subjects, Huaibei, Anhui Province, 235000, China.
authors.forename: Duan-hua
authors.initials: DH
authors.lastname: Li
authors.forename: Chao-jie
authors.initials: CJ
authors.lastname: Wang
authors.forename: Shu-sheng
authors.initials: SS
authors.lastname: Zhang
authors.forename: Heng
authors.initials: H
authors.lastname: Mao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055008:Anthracosis / Q000150:complications / Q000188:drug therapy*; D003032:Coal Mining; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D019821:Simvastatin / Q000627:therapeutic use*
chemical_list: D019821:Simvastatin