title: Potential dopamine-1 receptor stimulation in hypertension management.
abstract: The role of dopamine receptors in blood pressure regulation is well established. Genetic ablation of both dopamine D1-like receptor subtypes (D1, D5) and D2-like receptor subtypes (D2, D3, D4) results in a hypertensive phenotype in mice. This review focuses on the dopamine D1-like receptor subtypes D1 and D5 (especially D1 receptors), as they play a major role in regulating sodium homeostasis and blood pressure. Studies mostly describing the role of renal dopamine D1-like receptors are included, as the kidneys play a pivotal role in the maintenance of sodium homeostasis and the long-term regulation of blood pressure. We also attempt to describe the interaction between D1-like receptors and other proteins, especially angiotensin II type 1 and type 2 receptors, which are involved in the maintenance of sodium homeostasis and blood pressure. Finally, we discuss a new concept of renal D1 receptor regulation in hypertension that involves oxidative stress mechanisms.
authors.affiliation: Heart and Kidney Institute, College of Pharmacy, University of Houston, Houston, TX 77204, USA. masghar@uh.edu
authors.forename: Mohammad
authors.initials: M
authors.lastname: Asghar
authors.forename: Seyed K
authors.initials: SK
authors.lastname: Tayebati
authors.forename: Mustafa F
authors.initials: MF
authors.lastname: Lokhandwala
authors.forename: Tahir
authors.initials: T
authors.lastname: Hussain
mesh_terms: D001794:Blood Pressure / Q000187:drug effects*; D054768:G-Protein-Coupled Receptor Kinases; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics; D018384:Oxidative Stress; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D017447:Receptors, Dopamine D1 / Q000096:biosynthesis* / Q000187:drug effects
chemical_list: D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D017447:Receptors, Dopamine D1; D054768:G-Protein-Coupled Receptor Kinases