title: A multinational study of the influence of health-related quality of life on in-hospital outcome after coronary artery bypass graft surgery.
abstract: BACKGROUND
  The effect of health-related quality of life on in-hospital outcomes after coronary artery bypass grafting surgery has not been investigated in international multicenter studies. We hypothesized that poor preoperative health status is associated with mortality and length of hospital stay.
  
  
  METHODS
  In the Multicenter Study of Perioperative Ischemia Epidemiology II, preoperative Short-Form 12, Mental Component Summary (MCS), and Physical Component Summary (PCS) scores were obtained prospectively from 4,811 patients (3,834 men, 977 women) undergoing coronary artery bypass grafting surgery at 72 centers in 17 countries. Primary outcome measures were in-hospital mortality and prolonged (>14 days) length of hospital stay.
  
  
  RESULTS
  One hundred fifty-one patients (3.1%) died. After adjustment for regional differences, a 10-point reduction in MCS score was associated with higher mortality risk (odds ratio [OR] 1.17, 95% CI 1.004-1.37, P = .04) and prolonged hospital stay (OR 1.11, 95% CI 1.01-1.21, P = .03). The preoperative PCS score was not associated with mortality risk but significantly predicted prolonged length of hospital stay (OR 1.20, 95% CI 1.09-1.33, P < .001). There was no significant interaction between gender and either the MCS or the PCS score.
  
  
  CONCLUSIONS
  The preoperative PCS predicted prolonged postoperative hospital stay, whereas the preoperative MCS score was an independent predictor of both prolonged length of hospital stay and mortality. Preoperative assessment of health-related quality of life factors with the Short-Form 12 might be a useful tool for risk stratification and planning for hospital discharge and rehabilitation.
authors.affiliation: Department of Anesthesia and Intensive Care, Semmelweis University, Budapest, Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Székely
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Nussmeier
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Miao
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
authors.forename: Jack
authors.initials: J
authors.lastname: Levin
authors.forename: Helena
authors.initials: H
authors.lastname: Feierfeil
authors.forename: Dennis T
authors.initials: DT
authors.lastname: Mangano
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D005260:Female; D006304:Health Status; D006305:Health Status Indicators; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay; D008297:Male; D017063:Outcome Assessment, Health Care; D011788:Quality of Life