title: [Association of single nucleotide polymorphism in CYP17 and ERα genes with endometriosis risk in southern Chinese women].
abstract: OBJECTIVE
  To investigate the association of single nucleotide polymorphisms in cytochrome P450 17 (CYP17) and estrogen receptor alpha (ERα ) genes with the risk of endometriosis among southern Chinese women.
  
  
  METHODS
  Two SNPs rs743572 (CYP17 gene 34T/C) and rs9322331 (ERα gene -397T/C) were genotyped by high resolution melting curve in 432 endometriosis patients and 499 matched controls.
  
  
  RESULTS
  There was no significant difference in the genotype frequencies of the two loci between endometriosis patients and the control subjects (P> 0.05). And there was no significant interaction effect of these two genes on the disease either.
  
  
  CONCLUSIONS
  CYP17 gene and ERα gene may not be genetic risk factors for endometriosis among southern women in China.
authors.affiliation: Department of Gynecology and Obstetrics, Zhujiang Hospital, Nanfang Medical University, Guangzhou, Guangdong, 510280 P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Li-li
authors.initials: LL
authors.lastname: Zong
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Mao
authors.forename: Yong-gui
authors.initials: YG
authors.lastname: Fu
authors.forename: Jun
authors.initials: J
authors.lastname: Zeng
authors.forename: Xing-qiang
authors.initials: XQ
authors.lastname: Rao
mesh_terms: D044466:Asian People / Q000235:genetics; D004715:Endometriosis / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*
chemical_list: D047628:Estrogen Receptor alpha; D013254:Steroid 17-alpha-Hydroxylase