title: [Expression of platelet-derived growth factor receptor α and its ligand PDGF- A in breast cancer].
abstract: OBJECTIVE
  To investigate the potential significance of platelet-derived growth factor receptor-α (PDGFR-α) and platelet-derived growth factor A (PDGF-A) expression in mammary carcinomas, and analyze its correlation with the lymph node metastasis and the expression of PDGF-A.
  
  
  METHODS
  Used immunohistochemistry to detect the protein expression of PDGFR-α and PDGF-A in paraffinembedded breast carcinomas.
  
  
  RESULTS
  The expression of PDGFR-α and PDGF-A were observed in 51.7% and 61.7% in the breast carcinomas, respectively and showed an association with lymph node metastasis (P < 0. 05). A correlation was also found with the expression of PDGFR-α and PDGF-A (P<0.05).
  
  
  CONCLUSIONS
  PDGFR-α is expressed in invasive breast carcinomas and is associated with biological aggressiveness.
authors.affiliation: Qiqihar Medical College, Heilongjiang Province, Qiqihar 161006, China.
authors.forename: De-shui
authors.initials: DS
authors.lastname: Liu
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Chang-fang
authors.initials: CF
authors.lastname: Lu
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008024:Ligands; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism*
chemical_list: D008024:Ligands; D010982:Platelet-Derived Growth Factor; C075278:platelet-derived growth factor A; D020796:Receptor, Platelet-Derived Growth Factor alpha