title: Abnormal brain protein synthesis in language areas of children with pervasive developmental disorder: a L-[1-11C]-leucine PET study.
abstract: This study was performed to evaluate the cerebral protein synthesis rate of language brain regions in children with developmental delay with and without pervasive developmental disorder. The authors performed L-[1-(11)C]-leucine positron emission tomography (PET) on 8 developmental delay children with pervasive developmental disorder (mean age, 76.25 months) and 8 developmental delay children without pervasive developmental disorder (mean age, 77.63 months). They found a higher protein synthesis rate in developmental delay children with pervasive developmental disorder in the left posterior middle temporal region (P = .014). There was a significant correlation of the Gilliam Autism Rating Scale autism index score with the protein synthesis rate of the left posterior middle temporal region (r = .496, P = .05). In addition, significant asymmetric protein synthesis (right > left) was observed in developmental delay children without pervasive developmental disorder in the middle frontal and posterior middle temporal regions (P = .03 and P = .04, respectively). In conclusion, abnormal language area protein synthesis in developmentally delayed children may be related to pervasive symptoms.
authors.affiliation: Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: Varun
authors.initials: V
authors.lastname: Shandal
authors.forename: Senthil K
authors.initials: SK
authors.lastname: Sundaram
authors.forename: Diane C
authors.initials: DC
authors.lastname: Chugani
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.forename: Michael E
authors.initials: ME
authors.lastname: Behen
authors.forename: Harry T
authors.initials: HT
authors.lastname: Chugani
mesh_terms: D000704:Analysis of Variance; D001931:Brain Mapping; D002247:Carbon Isotopes; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000000981:diagnostic imaging / Q000473:pathology*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007930:Leucine; D008279:Magnetic Resonance Imaging; D008297:Male; D049268:Positron-Emission Tomography; D014176:Protein Biosynthesis / Q000502:physiology*; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000378:metabolism*
chemical_list: D002247:Carbon Isotopes; D007930:Leucine