title: Nod-like receptors in intestinal homeostasis, inflammation, and cancer.
abstract: NLRs have been shown in a number of models to protect against microbial infection through their ability to participate in "pattern recognition" and their triggering of inflammatory pathways to control infection. Over the past few years, however, the role of NLRs, especially Nod1, Nod2, and NLRP3, in intestinal homeostasis has been highlighted. Indeed, these specific NLRs have been implicated in IBD, in particular, the association of Nod2 with CD, yet a clear understanding of how dysfunctional NLR activation leads to aberrant inflammation is still the focus of much investigation. In this review, we will examine how NLRs participate in the maintenance of gut homeostasis and how upset of this regulation can tip the balance toward chronic inflammation and intestinal cancer.
authors.affiliation: Institut Pasteur, Biology and Genetics of Bacterial Cell Wall, Avenir Group INSERM, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Werts
authors.forename: Stephen
authors.initials: S
authors.lastname: Rubino
authors.forename: Arthur
authors.initials: A
authors.lastname: Ling
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Girardin
authors.forename: Dana J
authors.initials: DJ
authors.lastname: Philpott
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism; D007414:Intestinal Neoplasms / Q000209:etiology* / Q000378:metabolism; D053472:Nod Signaling Adaptor Proteins / Q000378:metabolism*
chemical_list: D053472:Nod Signaling Adaptor Proteins