title: [Hematologic diseases: from within the heart].
abstract: The fundamental relationship between blood disorders and the cardiovascular system originates within multiple points of interface, ranging from the heart and its structural constituents to include heart chambers, valves, coronary arteries, coronary veins, and the cerebrovascular and peripheral vasculature. While the cellular components of circulating blood derive their primary origin from multipotent progenitor cells, plasma-based components, which include coagulation proteins, are mostly born of hepatic synthesis and endothelial cells. Here we provide a focused overview of nononcological blood disorders and their potential impact on the arterial circulatory system as common phenotypes, including myocardial infarction, ischemic stroke and peripheral arterial occlusive events. Venous thromboembolism is employed in our discussion as a clinical template. We also provide practical steps and guidance for diagnostic testing and management in routine clinical practice. Full English text available from: www.revespcardiol.org.
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Weixian
authors.initials: W
authors.lastname: Xu
authors.forename: Tracy Y
authors.initials: TY
authors.lastname: Wang
authors.forename: Richard C
authors.initials: RC
authors.lastname: Becker
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000150:complications / Q000628:therapy; D001791:Blood Platelet Disorders / Q000150:complications / Q000628:therapy; D004912:Erythrocytes; D006331:Heart Diseases / Q000150:complications* / Q000628:therapy; D006402:Hematologic Diseases / Q000150:complications* / Q000628:therapy; D006801:Humans; D019851:Thrombophilia / Q000150:complications; D013927:Thrombosis / Q000150:complications / Q000517:prevention & control / Q000628:therapy