title: Outcome of a solitary kidney transplant into adult recipients from pediatric donors after controlled circulatory death.
abstract: OBJECTIVE
  We sought to evaluate the outcomes of a single kidney transplant from pediatric donors into adult recipients after controlled circulatory death.
  
  
  METHODS
  A retrospective, single-center review of all adult recipients who received a single pediatric kidney from controlled-cardiac deceased-donors (aged, < 9 years old) between January 2006 and March 2008 was performed.
  
  
  RESULTS
  Eleven adult recipients (aged, 16-41 years) used single renal grafts from the controlled-cardiac deceased-donors (median donor age, 74 months; range, 49-106 months; median donor weight, 20.95 kg; range, 16.6-37.8 kg). The median recipient age was 27 years (range, 16-41 years; median recipient weight, 47 kg; range 39.5-53.6 kg). The patient's serum creatinine level gradually decreased, and the estimated glomerular filtration rate increased stably more than 2 times during follow-up. The graft length increased significantly the first week after transplant compared with that recorded immediately after reperfusion (P < .001) and grew slightly thereafter. Acute rejection occurred in 1 patient. Nine patients had high renal artery blood flow velocity index at 1 to 2 cm. Beside the anastomosis (167-321 cm/s), only 1 patient developed hypertension and slightly increased serum creatinine at 14 weeks after transplant. The 1-year patient/graft survival was 100%.
  
  
  CONCLUSIONS
  Use of single kidneys from pediatric donors after controlled cardiac death could expand the donor pool without compromising recipient outcomes.
authors.affiliation: Department of Organ Transplantation, Changzheng Hospital, Shanghai, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yuan
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: Meisheng
authors.initials: M
authors.lastname: Zhou
authors.forename: Youhua
authors.initials: Y
authors.lastname: Zhu
authors.forename: Jindong
authors.initials: J
authors.lastname: Li
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001926:Brain Death; D002648:Child; D002681:China; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007166:Immunosuppressive Agents; D003404:Creatinine