title: A simple bias correction in linear regression for quantitative trait association under two-tail extreme selection.
abstract: Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.
authors.affiliation: Department of Psychiatry, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors.forename: Johnny S H
authors.initials: JS
authors.lastname: Kwan
authors.forename: Annie W C
authors.initials: AW
authors.lastname: Kung
authors.forename: Pak C
authors.initials: PC
authors.lastname: Sham
mesh_terms: D000465:Algorithms; D004843:Epistasis, Genetic; D005823:Genetics; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D012044:Regression Analysis; D015203:Reproducibility of Results