title: Cancer immunology and colorectal cancer recurrence.
abstract: The recurrence of a cancer - local or distant (metastasis) - is manifested by the persistence of cancer cells in the organism after the ablation of the primary lesion, an ineffective anticancer immune response, and by the activity of biological/immunological factors that can stimulate and sustain its development. This review focuses on colorectal carcinoma and discusses some aspects of cancer immunology regarding cancer development and its recurrence. It is addressed also to the clinician to provide new insights helpful for designing better therapeutic strategies and patient's follow up. Therapeutic approaches used during and after surgical treatments, found capable of modulating immunity (differently affecting disease outcome), will also be described.
authors.affiliation: Laboratory of Natural Cell Immunity, Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, vvi, Prague, Czech Republic. vannucci@biomed.cas.cz
authors.forename: Luca
authors.initials: L
authors.lastname: Vannucci
mesh_terms: D015179:Colorectal Neoplasms / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007249:Inflammation / Q000276:immunology*; D016328:NF-kappa B / Q000378:metabolism; D009362:Neoplasm Metastasis / Q000276:immunology / Q000517:prevention & control*; D009364:Neoplasm Recurrence, Local / Q000276:immunology / Q000517:prevention & control*; D050796:STAT3 Transcription Factor / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human