title: Ovarian cancer-associated polymorphisms in the BNC2 gene among women with endometriosis.
abstract: BACKGROUND
  Endometriosis is a common benign gynaecological disease. Epidemiological studies have demonstrated associations between endometriosis and ovarian cancer. Recent genome-wide association studies of ovarian cancer have identified several single nucleotide polymorphisms (SNPs) in the Basonuclin 2 (BNC2) gene. In this study, we investigated these polymorphism in women with endometriosis.
  
  
  METHODS
  Six SNPs in and upstream of the BNC2 gene (rs3814113, rs4445329, rs10962656, rs12379183, rs10756819 and rs1339552) were investigated using TaqMan allelic discrimination analysis in a Caucasian population (cases: 798, controls: 351). Allelic frequencies were used as main outcome measure.
  
  
  RESULTS
  No associations were observed between the analysed SNPs and endometriosis.
  
  
  CONCLUSIONS
  Our results suggest that the analysed polymorphisms in the BNC2 gene are unlikely to contribute to the previously reported risk of ovarian cancer in women with endometriosis.
authors.affiliation: Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet/Karolinska University Hospital, 171 76 Stockholm, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Sundqvist
authors.forename: H
authors.initials: H
authors.lastname: Falconer
authors.forename: M
authors.initials: M
authors.lastname: Seddighzadeh
authors.forename: A
authors.initials: A
authors.lastname: Vodolazkaia
authors.forename: A
authors.initials: A
authors.lastname: Fassbender
authors.forename: C
authors.initials: C
authors.lastname: Kyama
authors.forename: A
authors.initials: A
authors.lastname: Bokor
authors.forename: O
authors.initials: O
authors.lastname: Stephansson
authors.forename: K
authors.initials: K
authors.lastname: Gemzell-Danielsson
authors.forename: T M
authors.initials: TM
authors.lastname: D'Hooghe
mesh_terms: D000328:Adult; D004268:DNA-Binding Proteins / Q000235:genetics*; D004715:Endometriosis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C484527:BNC2 protein, human; D004268:DNA-Binding Proteins