title: Changes and significance of IL-25 in chicken collagen II-induced experimental arthritis (CIA).
abstract: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. It is a systemic inflammatory disease, characterized by chronic, symmetrical, multi-articular synovial arthritis. IL-25 (IL-17E) is a member of the recently emerged cytokine family (IL-17s), which is expressed in Th2 cells and bone marrow-derived mast cells. Unlike the other members of this family, IL-25 is capable of inducing Th2-associated cytokines (IL-4, IL-5, and IL-13) and also promotes the release of some pro-immune factors (IL-6 and IL-8). IL-25 is also a pleiotropic factor, which constitutes a tissue-specific pathological injury and chronic inflammation. In this study, we used chicken collagen II-induced experimental arthritis (CIA) model in DBA/1 mice to investigate the relationship between IL-25 and other inflammatory factors, revealing the possible mechanism in CIA. Our results showed that the expression level of IL-25 was enhanced in the late stage of CIA, and IL-17 was increased in the early stage of the disease. It is well known that IL-17 has a crucial role in the development of RA pathogenesis, and IL-25 plays a significant role in humoral immune. For reasons given above, we suggested that the IL-25 inhibited IL-17 expression to some extent, while enhancing the production of IL-4. It was confirmed that IL-25 not only regulated the cellular immune, but also involved the humoral immune in rheumatoid arthritis.
authors.affiliation: Department of Immunology, Institute of Laboratory Medicine, Jiangsu University, 212013 Zhenjiang, People's Republic China.
authors.forename: Wang
authors.initials: W
authors.lastname: Kaiwen
authors.forename: Su
authors.initials: S
authors.lastname: Zhaoliang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yinxia
authors.forename: Sandoghchian Shotorbani
authors.initials: SS
authors.lastname: Siamak
authors.forename: Jiao
authors.initials: J
authors.lastname: Zhijun
authors.forename: Xue
authors.initials: X
authors.lastname: Yuan
authors.forename: Yang
authors.initials: Y
authors.lastname: Heng
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dong
authors.forename: Liu
authors.initials: L
authors.lastname: Yanfang
authors.forename: Shen
authors.initials: S
authors.lastname: Pei
authors.forename: Wang
authors.initials: W
authors.lastname: Shengjun
authors.forename: Shao
authors.initials: S
authors.lastname: Qixiang
authors.forename: Huang
authors.initials: H
authors.lastname: Xinxiang
authors.forename: Lu
authors.initials: L
authors.lastname: Liwei
authors.forename: Xu
authors.initials: X
authors.lastname: Huaxi
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D002478:Cells, Cultured; D002645:Chickens; D024043:Collagen Type II; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D018836:Inflammation Mediators / Q000097:blood*; D007371:Interferon-gamma / Q000097:blood; D020381:Interleukin-17 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D007719:Knee Joint / Q000276:immunology* / Q000473:pathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D013154:Spleen / Q000276:immunology; D013997:Time Factors
chemical_list: D015415:Biomarkers; D024043:Collagen Type II; D018836:Inflammation Mediators; D020381:Interleukin-17; D007378:Interleukins; C442281:Mydgf protein, mouse; D015847:Interleukin-4; D007371:Interferon-gamma