title: Critical chronic peripheral arterial disease: does outcome justify crural or pedal bypass surgery in patients with advanced age or with comorbidities?
abstract: BACKGROUND
  We wanted to know the effect of comorbidity, age, and gender on the outcome after surgical below-knee revascularization for critical chronic limb ischemia.
  
  
  METHODS
  This is a retrospective study of 624 consecutive patients who underwent below-knee bypass surgery between January 1996 and December 2005 because of chronic peripheral arterial disease (PAD). Patients' characteristics were: diabetes mellitus (DM) n = 445 (71%), coronary artery disease (CAD) n = 310 (49%), dialysis-dependent renal insufficiency (dRI) n = 88 (14%), age >70 years n = 279 (44%), male n = 423 (68%), PAD Fontaine's stage III n = 105 (17%), and PAD stage 4 n =519 (83%). All patients had Trans Atlantic Inter-Society Consensus (TASC) C and D lesions, all were treated with a vein bypass to a crural artery n = 354 (57%) and to a pedal artery n = 270 (43%). Kaplan-Meier analysis and multivariate analysis were performed.
  
  
  RESULTS
  The early results were as follows. The 30-day major amputation rate was n = 43 (7%). CAD, dRI, age, and gender did not influence major amputation rate, whereas patients with diabetes had a lower risk of early amputation than those without diabetes. (hazard ratio: 0.49, 95% confidence interval: 0.25-0.95, p < 0.05). The 30-day mortality rate was n = 31 (5%) and was uninfluenced by DM, CAD, and gender. Patients with dRI and octogenarians had a high risk of early death (dRI: 13.6%, octogenarians 9.4%). The late results were as follows. Follow-up rates were: limb salvage n = 596 (95.5%) and survival n = 622 (99.7%). The limb salvage rates at 1, 3, and 5 years were 79.1%, 72.1%, and 66.4%, respectively, and were uninfluenced by DM, CAD, dRI, age, and gender. The mortality rates at 1-, 3-, and 5-years were 79%, 63.4%, and 47.3%, respectively. Comorbidities such as CAD, dRI, and age of >70 years reduced life expectancy significantly. DM did not influence 1, 3 and 5 years of survival. The 5-year survival rates as estimated by Kaplan-Meier analysis after revascularization were: DM, 46%; CAD, 38%; dRI, 19%; and age >70 years, 37%.
  
  
  CONCLUSIONS
  Advanced age and comorbidities reduce life span but not the chance of avoiding major amputation after below-knee bypass surgery for critical limb ischemia.
authors.affiliation: Clinic for Vascular Surgery and Kidney Transplantation, University Hospital of Düsseldorf, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany. weis.mueller@arcor.de
authors.forename: Barbara Theresia
authors.initials: BT
authors.lastname: Weis-Müller
authors.forename: Viktor
authors.initials: V
authors.lastname: Römmler
authors.forename: Ines
authors.initials: I
authors.lastname: Lippelt
authors.forename: Mark
authors.initials: M
authors.lastname: Porath
authors.forename: Erhard
authors.initials: E
authors.lastname: Godehardt
authors.forename: Kai
authors.initials: K
authors.lastname: Balzer
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Sandmann
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D016009:Chi-Square Distribution; D002908:Chronic Disease; D015897:Comorbidity; D016638:Critical Illness; D005260:Female; D005858:Germany; D006801:Humans; D007511:Ischemia / Q000401:mortality / Q000601:surgery*; D053208:Kaplan-Meier Estimate; D023821:Limb Salvage; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D058729:Peripheral Arterial Disease / Q000401:mortality / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000401:mortality