title: The role of lipid droplets in metabolic disease in rodents and humans.
abstract: Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.
authors.affiliation: Obesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA. Andrew.greenberg@tufts.edu
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Greenberg
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Coleman
authors.forename: Fredric B
authors.initials: FB
authors.lastname: Kraemer
authors.forename: James L
authors.initials: JL
authors.lastname: McManaman
authors.forename: Martin S
authors.initials: MS
authors.lastname: Obin
authors.forename: Vishwajeet
authors.initials: V
authors.lastname: Puri
authors.forename: Qing-Wu
authors.initials: QW
authors.lastname: Yan
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Mashek
mesh_terms: D017667:Adipocytes / Q000502:physiology / Q000648:ultrastructure; D000273:Adipose Tissue / Q000503:physiopathology*; D000818:Animals; D003920:Diabetes Mellitus / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology; D005227:Fatty Acids / Q000009:adverse effects / Q000378:metabolism; D005234:Fatty Liver / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D008055:Lipids / Q000502:physiology*; D008066:Lipolysis / Q000502:physiology; D008659:Metabolic Diseases / Q000503:physiopathology*; D051379:Mice; D008817:Mice, Mutant Strains; D018482:Muscle, Skeletal / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology; D014280:Triglycerides / Q000378:metabolism; D014617:Vacuoles / Q000502:physiology*
chemical_list: D005227:Fatty Acids; D047908:Intracellular Signaling Peptides and Proteins; D008055:Lipids; D014280:Triglycerides