title: New cassane diterpenes from Caesalpinia echinata.
abstract: An investigation of the ethanolic extract from stems of Caesalpinia echinata Lam (Leguminosae-Caesalpinioideae) led to the isolation of five new cassane diterpenes along with known lambertianic acid. Their structures were determined based on spectroscopic methods. A preliminary study on leishmanicidal activity demonstrated that compounds 1, 2 and 6 were found to inhibit the growth of amastigote-like forms of Leishmania amazonensis without affecting mononuclear cells obtained from human peripheral blood.
authors.affiliation: Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, 30190-002, Brazil. betania@cpqrr.fiocruz.br
authors.forename: Betania Barros
authors.initials: BB
authors.lastname: Cota
authors.forename: Djalma Menezes
authors.initials: DM
authors.lastname: de Oliveira
authors.forename: Ezequias Pessoa
authors.initials: EP
authors.lastname: de Siqueira
authors.forename: Elaine Maria
authors.initials: EM
authors.lastname: Souza-Fagundes
authors.forename: Adriano M C
authors.initials: AM
authors.lastname: Pimenta
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Santos
authors.forename: Ana
authors.initials: A
authors.lastname: Rabello
authors.forename: Carlos Leomar
authors.initials: CL
authors.lastname: Zani
mesh_terms: D029911:Caesalpinia / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D007891:Leishmania / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D002264:Carboxylic Acids; D004224:Diterpenes; D009281:Naphthalenes; D010936:Plant Extracts; D014344:Trypanocidal Agents; C421442:lambertianic acid