title: [Laminopathies. Nuclear lamina diseases].
abstract: Laminopathies are a group of diseases that share wrong codification of lamins, building proteins of the nuclear lamina. Different tissues are affected in those disorders: striated muscle, adipose tissue, central or peripheral nervous system and aging process. Emery-Dreifuss muscular dystrophy and Hutchinson-Gildford Progery Syndrome are two examples of laminopathies. Other diseases, due to mutations in different genes, impair lamins function by a direct or an indirect way and they are frequently considered together. The last decade has seen an increasing interest and scientific advances on laminopathies that will allow us to answer key questions regarding metabolism, insulin resistance, sudden death and aging. Laminopathies are reviewed in this article from a molecular, pathogenic and clinical point of view.
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA. ivan.mendez.lopez@cfnavarra.es
authors.forename: Iván
authors.initials: I
authors.lastname: Méndez-López
mesh_terms: D000375:Aging / Q000235:genetics / Q000502:physiology; D000818:Animals; D003645:Death, Sudden; D004195:Disease Models, Animal; D006801:Humans; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use; D034904:Lamin Type A / Q000172:deficiency / Q000235:genetics; D034921:Lamin Type B / Q000172:deficiency / Q000235:genetics; D034882:Lamins / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D020389:Muscular Dystrophy, Emery-Dreifuss / Q000235:genetics; D009685:Nuclear Envelope / Q000473:pathology*; D009928:Organ Specificity; D011371:Progeria / Q000235:genetics
chemical_list: C494847:LMNA protein, human; D034904:Lamin Type A; D034921:Lamin Type B; D034882:Lamins; D007334:Insulin-Like Growth Factor I