title: Synthesis and insecticidal activities of novel 1,3,4-thiadiazole 5-fluorouracil acetamides derivatives: an RNA interference insecticide.
abstract: A series of novel 1,3,4-thiadiazole 5-fluorouracil acetamides derivatives were designed and synthesized. Their structures were confirmed by infrared, (1)H NMR spectroscopy, and elemental analysis. The insecticidal activities against Tetranychus cinnabarinus and Aphis craccivora of these new compounds were evaluated. The bioassay tests showed that most of these title compounds possessed a good combination of stomach toxicity as well as contact toxicity against Tetranychus cinnabarinus and Aphis craccivora. In particular, the insecticidal activity of the title compound IVe against Aphis craccivora was better than the commercialized thiacloprid and was also comparable to another commercialized product, imidacloprid. The introduction of fluorines to meta and para-position of the benzene ring was essential for high bioactivity.
authors.affiliation: College of Science, Nanjing University of Technology, Nanjing, PR China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wan
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Fen
authors.initials: F
authors.lastname: Han
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Yu
authors.forename: Qiu
authors.initials: Q
authors.lastname: He
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001042:Aphids / Q000187:drug effects / Q000235:genetics; D005472:Fluorouracil / Q000737:chemistry* / Q000494:pharmacology; D005753:Gastric Mucosa / Q000378:metabolism; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007928:Lethal Dose 50; D034622:RNA Interference / Q000187:drug effects*; D013270:Stomach / Q000187:drug effects; D040102:Tetranychidae / Q000235:genetics; D013830:Thiadiazoles / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000081:Acetamides; D007306:Insecticides; D013830:Thiadiazoles; D005472:Fluorouracil