title: Klebsiella pneumoniae producing KPC carbapenemase in a district general hospital in the UK.
abstract: We report two patients with multidrug-resistant KPC-carbapenemase-producing Klebsiella pneumoniae urinary tract infections. A bla(KPC-2) gene was detected in both of the isolates by polymerase chain reaction and sequencing. The isolates had identical pulsed-field gel electrophoresis patterns and belonged to sequence type ST11. The index patient probably acquired the KPC-producing strain while in hospital in Curaçao, with subsequent nosocomial transmission to the second patient occurring in our hospital. We describe the interventions that were taken to prevent its further spread within the acute Trust and the community.
authors.affiliation: Royal Berkshire NHS Foundation Trust, Reading, UK. Nilangi.Virgincar@royalberkshire.nhs.uk
authors.forename: N
authors.initials: N
authors.lastname: Virgincar
authors.forename: S
authors.initials: S
authors.lastname: Iyer
authors.forename: A
authors.initials: A
authors.lastname: Stacey
authors.forename: S
authors.initials: S
authors.lastname: Maharjan
authors.forename: R
authors.initials: R
authors.lastname: Pike
authors.forename: C
authors.initials: C
authors.lastname: Perry
authors.forename: J
authors.initials: J
authors.lastname: Wyeth
authors.forename: N
authors.initials: N
authors.lastname: Woodford
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D003428:Cross Infection / Q000382:microbiology / Q000635:transmission; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D006769:Hospitals, General; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology* / Q000635:transmission; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D008297:Male; D058889:Molecular Typing; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D006113:United Kingdom; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D047090:beta-Lactams; D001618:beta-Lactamases; C063912:carbapenemase