title: Synthesis of α-CN and α-CF3 N-heterocycles through tandem nucleophilic additions.
abstract: Using a readily available secondary aminoalkyne as starting material, a powerful strategy was discovered to prepare precursors of biologically important unnatural cyclic aminoacids and fluorinated N-heterocycles with important ring sizes (e.g., 5-7) in a one-pot reaction using two nucleophilic additions in a tandem fashion.
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA.
authors.forename: Junbin
authors.initials: J
authors.lastname: Han
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D000586:Amination; D000598:Amino Acids, Cyclic / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D017611:Fluorine Compounds / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D000598:Amino Acids, Cyclic; D003486:Cyanides; D017611:Fluorine Compounds; D006571:Heterocyclic Compounds