title: Latent toxoplasmosis in patients with different malignancy: a hospital based study.
abstract: BACKGROUND
  Seroprevalence of toxoplasmosis in different populations may vary according to different environments, social customs and habits. This study was designed to measure the seroprevalence of toxoplasmosis among patients with different malignancies and to ascertain the association between common risk factors and disease transmission.
  
  
  METHODS
  This Cross-sectional study was from January to April of 2009. Four Oncology wards in Hospital Universiti Kebangsaan Malaysia (HUKM) were selected as the site for undertaking the present study. The survey involved 129 patients with different malignancies. Information was gathered by using study subject information sheet and a standardized structured questionnaire. Toxoplasma was screened by a standerd ELISA commercial kit in accordance with the manufacturers instructions and performed at the Department of Microbiology, HUKM Kuala Lumpur. A result of > 51 IU/ml of anti-Toxoplasma (IgG) antibody was regarded as positive, indicating latent or pre-existing Toxoplasma infection. A result of > 51 IU/ml of anti-Toxoplasma (IgM) antibody was regarded as positive, indicating recently acquired Toxoplasma infection.
  
  
  RESULTS
  Total number of seropositive patients was 54 (67.6%), the mean age was 51 years (range15 - 88 years). Toxoplasma IgG positivity was highest among Malaysian (32%). Male to female ratio was almost equal. There was a statistically significant difference in seropositivity between patients living in rural areas compared to those living in urban areas, positive history of consumption of undercooked meat and/or blood transfusion (p < 0.05).
  
  
  CONCLUSIONS
  These findings give some support to Toxoplasma screening program and health education, including promotion of a healthy lifestyle exclusively in seronegative patients in order to prevent seroconversion and the incidence of clinically evident opportunistic infection.
  
  
  BACKGROUND
  Toxoplasma gondii; Risk factors; Immunocompromised; seroconversion; Seroprevalence.
authors.affiliation: Department of Pathology, Cyberjaya University College of Medical Sciences, Malaysia.
authors.forename: Amal
authors.initials: A
authors.lastname: Nimir
authors.forename: Amizah
authors.initials: A
authors.lastname: Othman
authors.forename: Soon
authors.initials: S
authors.lastname: Ee
authors.forename: Zohdy
authors.initials: Z
authors.lastname: Musa
authors.forename: Iffah Abd
authors.initials: IA
authors.lastname: Majid
authors.forename: Zalikha
authors.initials: Z
authors.lastname: Kamarudin
authors.forename: Chee
authors.initials: C
authors.lastname: Xian
authors.forename: Noor Hayati
authors.initials: NH
authors.lastname: Isa