title: MicroRNAs in the human pituitary.
abstract: MicroRNAs (miRNAs) represent a novel class of small RNA molecules that play a crucial role as post-transcriptional regulators of gene expression. As evidence for the involvement of miRNAs in various cellular processes increases, it is important to examine how miRNAs regulate gene expression. In the pituitary, aberrant miRNA expression is strongly linked with neoplasia, thus suggesting they play a role in the control of cell proliferation in adenomas. Research has built fundamental connections between aberrant miRNA expression and clinicopathological features of pituitary adenomas. Moreover, deregulated expression of miRNA target genes is often implicated in important biological pathways and thus provides significant insight into the role of miRNAs in tumorigenesis. This review will assess the significance of miRNAs in pituitary pathology.
authors.affiliation: Department of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, ON M5B1W8, Canada.
authors.forename: Milani
authors.initials: M
authors.lastname: Sivapragasam
authors.forename: Fabio
authors.initials: F
authors.lastname: Rotondo
authors.forename: Ricardo V
authors.initials: RV
authors.lastname: Lloyd
authors.forename: Bernd W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: Michael
authors.initials: M
authors.lastname: Cusimano
authors.forename: Luis V
authors.initials: LV
authors.lastname: Syro
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs
mesh_terms: D000236:Adenoma / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D010902:Pituitary Gland / Q000378:metabolism* / Q000473:pathology; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013045:Species Specificity
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs