title: Homologous recombination research is heating up and ready for therapy.
authors.affiliation: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. powells@mskcc.org
authors.forename: Simon N
authors.initials: SN
authors.lastname: Powell
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Kachnic
mesh_terms: D000818:Animals; D024682:BRCA2 Protein / Q000235:genetics / Q000378:metabolism*; D016227:Benzoquinones / Q000494:pharmacology; D045744:Cell Line, Tumor; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D015151:Immunoblotting; D047029:Lactams, Macrocyclic / Q000494:pharmacology; D051379:Mice; D009374:Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D010793:Phthalazines / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism*; D011799:Quinazolines / Q000494:pharmacology; D034622:RNA Interference; D051381:Rats; D011995:Recombination, Genetic / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D014183:Transplantation, Heterologous; D047368:Tumor Burden / Q000187:drug effects / Q000528:radiation effects
chemical_list: D024682:BRCA2 Protein; D016227:Benzoquinones; D004268:DNA-Binding Proteins; D047029:Lactams, Macrocyclic; C115774:NU 1025; D010793:Phthalazines; D010879:Piperazines; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011799:Quinazolines; C110901:X-ray repair cross complementing protein 3; C448659:17-(dimethylaminoethylamino)-17-demethoxygeldanamycin; D011065:Poly(ADP-ribose) Polymerases; C531550:olaparib