title: Synthesis and Characterization of Ciprofloxacin Pendant Antibacterial Cationic Polymers.
abstract: A methacrylate monomer containing ciprofloxacin (CPF) was synthesized, followed by the free-radical co-polymerization of the methacrylate monomer, acrylamide and diallyl dimethyl ammonium chloride (DADMAC). The resulting antimicrobial cationic tripolymers were characterized by (1)H-NMR, gel-permeation chromatography, thermogravimetric analysis and differential scanning calorimetry. The in vitro antibacterial activity of the monomer, as well as of the polymers, was investigated against E. coli. The CPF pendant tripolymer exhibited excellent antibacterial activities, thus permitting the cationic tripolymers to be used as antibacterial intensifier, retention or filtration aid for various hygiene products, including those based on cellulose fibres.
authors.affiliation: a Department of Chemical Engineering, University of New Brunswick, Fredericton, NB E3B 5A3, Canada; Key Laboratory for Ultrafine Materials of Ministry of Education, Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xue
authors.forename: Y
authors.initials: Y
authors.lastname: Guan
authors.forename: A
authors.initials: A
authors.lastname: Zheng
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Xiao
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D002939:Ciprofloxacin / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004355:Drug Stability; D004926:Escherichia coli / Q000187:drug effects; D008689:Methacrylates / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D013696:Temperature
chemical_list: D000498:Allyl Compounds; D000900:Anti-Bacterial Agents; D008689:Methacrylates; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D002939:Ciprofloxacin; C508190:diallyldimethylammonium chloride