title: Nuclear translocation of the cytoskeleton-associated protein, smALP, upon induction of skeletal muscle differentiation.
abstract: The skALP isoform has been shown to play a critical role in actin organization and anchorage within the Z-discs of skeletal muscles, but no data is available on the function of the smALP isoform in skeletal muscle cells. Here, we show that upon induction of differentiation a nuclear translocation of smALP from the cytoplasm to the nucleus of C2C12 myoblasts, concomitant to an up-regulation of the protein expression, occurs in parallel with the nuclear accumulation of myogenin. Moreover, we demonstrate that the LIM domain of smALP is essential for the nuclear translocation of the protein.
authors.affiliation: CNRS UMR5237, Université Montpellier 1, Université Montpellier 2, Centre de Recherche en Biochimie Macromoléculaire, Montpellier, France.
authors.forename: Linda
authors.initials: L
authors.lastname: Cambier
authors.forename: Pascal
authors.initials: P
authors.lastname: Pomiès
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D060588:LIM Domain Proteins; D051379:Mice; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000378:metabolism*; D018008:Myogenin / Q000378:metabolism; D017434:Protein Structure, Tertiary
chemical_list: D060588:LIM Domain Proteins; D008840:Microfilament Proteins; D018008:Myogenin; C484642:Pdlim3 protein, mouse; C484641:Pdlim3 protein, rat