title: Delayed fingolimod-associated asystole.
abstract: Oral fingolimod (Gilenya) is a sphingosine-1-phosphate-receptor modulator that prevents the egress of lymphocytes from lymph nodes. Fingolimod reduces relapses and delays disability progression in patients with relapsing forms of multiple sclerosis (MS). We report a patient with MS who developed asystole and sustained bradycardia 21 hours after the first dose of fingolimod.
authors.affiliation: North Oaks Neurology, Hammond, LA, USA. ps.espinosa@gmail.com
authors.forename: Patricio S
authors.initials: PS
authors.lastname: Espinosa
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Berger
mesh_terms: D000284:Administration, Oral; D014150:Antipsychotic Agents / Q000009:adverse effects; D001919:Bradycardia / Q000139:chemically induced; D004562:Electrocardiography; D000068876:Fingolimod Hydrochloride; D006323:Heart Arrest / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011409:Propylene Glycols / Q000008:administration & dosage / Q000009:adverse effects*; D018967:Risperidone / Q000009:adverse effects; D013110:Sphingosine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D013997:Time Factors; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D007166:Immunosuppressive Agents; D011409:Propylene Glycols; D000068876:Fingolimod Hydrochloride; D018967:Risperidone; D013110:Sphingosine