title: Chemopreventive effect of hydroethanolic extract of Euphorbia neriifolia leaves against DENA-induced renal carcinogenesis in mice.
abstract: The present study was conducted to investigate the chemopreventive effects of hydro-ethanolic extract of Euphorbia neriifolia (EN) on N-nitrosodiethylamine (DENA) induced renal cancer in male Swiss albino mice. Animals were pretreated with EN extract (150 and 400 mg/kg body weight; p.o) and butylated hydroxyanisole (BHA) as a standard (0.5% and 1% BHA p.o) both for two week prior to the administration of single dose of DENA (50 mg/kg body weight; p.o). Various in vivo antioxidant biochemical parameters like lipid peroxidation (LPO), superoxide dismutase (SOD), and catalase (CAT) were evaluated to determine the reno-protective and antioxidant activity of EN. DENA increased oxidative stress through increase in LPO and decrease in antioxidant enzymes (SOD, and CAT). The EN extract significantly restored the antioxidant enzyme level in the kidney and exhibited significant dose dependant protective effect against DENA induced nephrotoxicity, which can be mainly attributed to the antioxidant property of the extract. This study rationalized the ethno-medicinal use of EN for protection against renal cancer.
authors.affiliation: Bioscience and Biotechnology, Banasthali University, Banasthali, India. drvshs@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Pracheta
authors.forename: Veena
authors.initials: V
authors.lastname: Sharma
authors.forename: Lokendra
authors.initials: L
authors.lastname: Singh
authors.forename: Ritu
authors.initials: R
authors.lastname: Paliwal
authors.forename: Sadhana
authors.initials: S
authors.lastname: Sharma
authors.forename: Sachdev
authors.initials: S
authors.lastname: Yadav
authors.forename: Shatruhan
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000477:Alkylating Agents / Q000633:toxicity; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002374:Catalase / Q000378:metabolism; D004052:Diethylnitrosamine / Q000633:toxicity*; D000431:Ethanol / Q000737:chemistry*; D028481:Euphorbia / Q000737:chemistry*; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D018384:Oxidative Stress; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism; D015996:Survival Rate
chemical_list: D000477:Alkylating Agents; D000975:Antioxidants; D010936:Plant Extracts; D004052:Diethylnitrosamine; D000431:Ethanol; D002374:Catalase; D013482:Superoxide Dismutase