title: Effect of the endothelial glycocalyx layer on arterial LDL transport under normal and high pressure.
abstract: To quantitatively investigate the role of the endothelial glycocalyx layer (EGL) in protecting the artery from excessive infiltration of atherogenic lipids such as low density lipoproteins (LDLs), a multilayer model with the EGL of an arterial segment was developed to numerically simulate the flow and the transport of LDLs under normal and high pressure. The transport parameters of the layers of the model were obtained from the hydrodynamic theory, the stochastic theory, and from the literature. The results showed that the increase in the thickness of the EGL could lead to a sharp drop in LDL accumulation in the intima. A partial damage to the EGL could compromise its barrier function, hence leading to enhanced infiltration/accumulation of LDLs within the wall of the arterial model. Without the EGL, hypertension could lead to a significantly enhanced LDL transport into the wall of the model. However, the intact EGL could protect the arterial wall from hypertension so that the LDL concentration in the intima layer was almost the same as that under normal pressure conditions. The results also showed that LDL concentration within the arterial wall increased with Φ (the fraction of leaky junctions) on the intima layer. The increase in LDL concentration with Φ was much more dramatic for the model without the EGL. For instance, without the EGL, a Φ of 0.0005 could lead LDL concentration within the arterial wall to be even higher than that predicted for the EGL intact model with a Φ of 0.002. In conclusion, an intact EGL with a sufficient thickness may act as a barrier to LDL infiltration into the arterial wall and has the potential to suppress the hypertension-driven hike of LDL infiltration/accumulation in the arterial wall.
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.forename: Yubo
authors.initials: Y
authors.lastname: Fan
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Deng
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D001692:Biological Transport / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology*; D019276:Glycocalyx / Q000473:pathology / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008955:Models, Cardiovascular; D010539:Permeability; D010865:Pilot Projects; D017539:Tunica Intima / Q000378:metabolism
chemical_list: D008077:Lipoproteins, LDL