title: A new cytotoxic β-carboline alkaloid from Galianthe thalictroides.
abstract: A cytotoxicity-guided fractionation of the roots of Galianthe thalictroides afforded a new β-carboline alkaloid, 1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H- β-carbolin-1-yl)cyclopentanol, which exhibited strong cytotoxic activity against three human cancer cell lines (MCF-7, 786-0, and UACC62). Its structure was established on the basis of 1D- and 2D-NMR spectroscopic techniques supported by HRMS data.
authors.affiliation: Departamento de Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Patrícia O
authors.initials: PO
authors.lastname: Figueiredo
authors.forename: Fernanda R
authors.initials: FR
authors.lastname: Garcez
authors.forename: Maria de Fátima C
authors.initials: Mde F
authors.lastname: Matos
authors.forename: Renata T
authors.initials: RT
authors.lastname: Perdomo
authors.forename: Lyara M M
authors.initials: LM
authors.lastname: Queiroz
authors.forename: Arnildo
authors.initials: A
authors.lastname: Pott
authors.forename: Airton J S
authors.initials: AJ
authors.lastname: Garcez
authors.forename: Walmir S
authors.initials: WS
authors.lastname: Garcez
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003517:Cyclopentanes; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: C000592656:1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-beta-carbolin-1-yl)-cyclopentanol; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002243:Carbolines; D003517:Cyclopentanes; D010936:Plant Extracts