title: Trends in the treatment outcomes for advanced colorectal cancer: an analysis at a single community hospital in Japan.
abstract: OBJECTIVE
  To evaluate the trends in the treatment outcomes for patients with colorectal cancer in Japan.
  
  
  METHODS
  We performed a retrospective analysis of patients undergoing surgery for primary colorectal cancer during a 16-year period (Group A [1992-2000, n = 258]; Group B [2001-2008, n = 258]) at Fukuoka City Hospital. Because no significant differences were found in the survival rates in stage 0, I, II, and III patients between the two groups, we concentrated on examining stage IV patients.
  
  
  RESULTS
  The 3-year survival rate for stage IV patients in Group B (n = 26) was significantly higher than that in Group A (n = 31) (34.9% vs 3.9%, P < 0.05). The rate of curative resection for advanced liver metastases in Group B patients was also significantly higher than that of Group A patients (50.0% vs 13.3%, P < 0.05). As a result, the 2-year survival rate for the disease-free patients in Group B was significantly higher than that for the non-disease-free patients in Group B (46.0% vs 21.0%, P < 0.05). Group B had a greater proportion of patients receiving l-leucovorin/5-fluorouracil than Group A (8 patients vs none, P < 0.05).
  
  
  CONCLUSIONS
  Recent advances in surgical innovations and the utilization of new chemotherapeutic agents may have led to significant improvements in the treatment outcomes for advanced colorectal cancer in Japan.
authors.affiliation: Department of Surgery, Fukuoka City Hospital, Fukuoka, 812-0046, Japan.
authors.forename: Morimasa
authors.initials: M
authors.lastname: Tomikawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Korenaga
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Akahoshi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kohshi
authors.forename: Keishi
authors.initials: K
authors.lastname: Sugimachi
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Kenji
authors.initials: K
authors.lastname: Takenaka
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006764:Hospitals, Community / Q000706:statistics & numerical data / Q000639:trends*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome