title: Barrett's adenocarcinoma of the esophagus: better outcomes through new methods of diagnosis and treatment.
abstract: BACKGROUND
  Esophageal adenocarcinoma has attracted more attention among gastroenterologists recently because of its rapidly rising incidence in Western countries. Many new epidemiological findings have been published, and there have been numerous technical advances in diagnostic procedures and in multimodal treatment based on the staging of the disease.
  
  
  METHODS
  In this paper, we selectively review the literature on esophageal adenocarcinoma, also considering the evidence-based recommendations contained in the guidelines of the German Society for Digestive and Metabolic Diseases (Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten, DGVS) as well as the latest data from our own research team.
  
  
  CONCLUSIONS
  here have been major recent advances in the diagnosis and treatment of esophageal adenocarcinoma. New refinements in endoscopic techniques now make endoscopic treatment possible for early esophageal carcinoma. New surgical techniques and new strategies of neoadjuvant chemotherapy have lowered the morbidity and improved the outcome of patients with locally advanced disease. Molecular therapies, too, have shown promising initial results.
authors.affiliation: Dr. Horst-Schmidt-Kliniken Wiesbaden, Innere Medizin und Klinik Allgemein- und Viszeralchirurgie.
authors.forename: Angelika
authors.initials: A
authors.lastname: Behrens
authors.forename: Oliver
authors.initials: O
authors.lastname: Pech
authors.forename: Florian
authors.initials: F
authors.lastname: Graupe
authors.forename: Andrea
authors.initials: A
authors.lastname: May
authors.forename: Dietmar
authors.initials: D
authors.lastname: Lorenz
authors.forename: Christian
authors.initials: C
authors.lastname: Ell
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D004938:Esophageal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans