title: Au-catalyzed synthesis of 2-alkylindoles from N-arylhydroxylamines and terminal alkynes.
abstract: The first gold-catalyzed addition of N-arylhydroxylamines to aliphatic terminal alkynes is developed to access O-alkenyl-N-arylhydroxylamines, which undergo facile in situ sequential 3,3-rearrangements and cyclodehydrations to afford 2-alkylindoles with regiospecificity and under exceptionally mild reaction conditions.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.
authors.forename: Yanzhao
authors.initials: Y
authors.lastname: Wang
authors.forename: Longwu
authors.initials: L
authors.lastname: Ye
authors.forename: Liming
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D019811:Hydroxylamine / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D007211:Indoles; D019811:Hydroxylamine; D006046:Gold