title: Ovarian enzymatically active stromal cells can be a promoter of ovarian surface epithelial tumor.
abstract: Surface epithelial tumors (SETs) are the most common neoplasms of the ovary. They are traditionally thought derived from the ovarian surface or, as a recent hypothesis suggests, from various sources outside of ovary. Enzymatically active stromal cells (EASCs) are scattered in stroma of ovary, and characterized by their steroid-producing ability. With my observation of the increased EASCs near the epithelial cells of SETs, I hypothesize the epithelial cells of SETs can cause the increase of EASCs by converse adjacent stromal cells to EASCs; and EASCs, as a positive feedback, can prompt the proliferation of their neighbouring epithelial cells of SETs by secreting steroid hormone.
authors.affiliation: Department of Pathophysiololgy, Wenzhou Medical College, University Town, Wenzhou 325035, China. szj121@yahoo.com.cn
authors.forename: Zhangjuan
authors.initials: Z
authors.lastname: Song
mesh_terms: D049109:Cell Proliferation; D025461:Feedback, Physiological; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000503:physiopathology*; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000503:physiopathology*; D017154:Stromal Cells / Q000378:metabolism* / Q000502:physiology
chemical_list: D012739:Gonadal Steroid Hormones