title: Essential thrombocythemia and pregnancy.
abstract: Essential thrombocythaemia (ET) is an acquired myeloproliferative neoplasm, characterised by persistent thrombocytosis and a tendency for either thrombosis or haemorrhage. Among myeloproliferative neoplasms, ET is the most prevalent in young women, which constitute a special group due to their childbearing potential. An increased risk of fetal and maternal complications has been demonstrated in patients with ET. The most common pregnancy-related complication is spontaneous abortion during the first trimester. Recurrent abortion, fetal growth restriction, stillbirth and placental abruption are less frequent. Maternal complications are relatively rare and essentially represented by thromboembolic and bleeding events. Here we summarize the literature describing pregnancy and its outcome in patients with ET and discuss some recommendations for the management of pregnancy.
authors.affiliation: INSERM, U1048, Université Toulouse 3, I2MC, Equipe 9, CHU-Rangueil, Avenue Jean Poulhès BP84225, 31432 Toulouse Cedex 04, France.
authors.forename: Marie-Cécile
authors.initials: MC
authors.lastname: Valera
authors.forename: Olivier
authors.initials: O
authors.lastname: Parant
authors.forename: Christophe
authors.initials: C
authors.lastname: Vayssiere
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Arnal
authors.forename: Bernard
authors.initials: B
authors.lastname: Payrastre
mesh_terms: D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011256:Pregnancy Outcome; D012307:Risk Factors; D013920:Thrombocythemia, Essential / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*