title: Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe.
abstract: We report the first solid phase synthesis of a xanthone library CX and its application to embryonic stem cell probe development. The CX library was further derivatised with an activated ester resin to provide an acetylated CX (CXAC) library. Screening of these libraries led to the discovery of a novel fluorescent mESC probe, CDb8.
authors.affiliation: Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 117543 Singapore, Singapore.
authors.forename: Krishna Kanta
authors.initials: KK
authors.lastname: Ghosh
authors.forename: Hyung-Ho
authors.initials: HH
authors.lastname: Ha
authors.forename: Nam-Young
authors.initials: NY
authors.lastname: Kang
authors.forename: Yogeswari
authors.initials: Y
authors.lastname: Chandran
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D000818:Animals; D057930:Click Chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D053595:Embryonic Stem Cells / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D044004:Xanthones / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D054852:Small Molecule Libraries; D044004:Xanthones; C009689:xanthone