title: Detection of glucose abnormalities in patients with acute coronary heart disease: study of reliable tools in clinical practice.
abstract: OBJECTIVE
  To investigate the prevalence of glucose abnormalities in patients with acute coronary syndrome and to assess the reliability of certain clinical or analytical variables to predict a pathologic result of oral glucose tolerance test (OGTT) at 3 months from discharge.
  
  
  METHODS
  Prospective study of 102 patients admitted to the coronary care units. Patients were classified according to the American Diabetes Association criteria. Three months after discharge, an OGTT was performed to non-diabetic patients.
  
  
  RESULTS
  Forty-six (45.1%) patients were identified as diabetic (5 previously undiagnosed) and 56 (54.9%) as non-diabetic. OGTT identified 22% of diabetes, 33% of impaired glucose tolerance, and 45% of normal glucose tolerance. Fasting glucose (r=0.55, p<0.001), glycated hemoglobin (HbA1c) (r=0.46, p<0.001), low HDL cholesterol (HDLc) levels (r=-0.34, p<0.02), waist-hip ratio (r=0.45, p<0.01), high systolic blood pressure (r=0.5, p<0.01), and presence of acute myocardial infarction (r=0.46, p<0.001) at admission resulted significant to predict a pathologic result of OGTT.
  
  
  CONCLUSIONS
  Glucose abnormalities are frequent in acute coronary syndrome patients. Certain clinical and analytical markers at admission such as fasting glucose, HbA1c, HDL-c<40 mg/dl, waist-hip ratio, and systolic blood pressure, are useful to recognize patients with a higher predisposition to present a pathologic result in OGTT at 3 months from discharge.
authors.affiliation: Department of Endocrinology and Nutrition, University Hospital La Fe, Valencia, Spain. maribeldelolmo@gmail.com
authors.forename: M I
authors.initials: MI
authors.lastname: Del Olmo
authors.forename: J F
authors.initials: JF
authors.lastname: Merino-Torres
authors.forename: M
authors.initials: M
authors.lastname: Argente
authors.forename: A
authors.initials: A
authors.lastname: Ramos
authors.forename: M S
authors.initials: MS
authors.lastname: Navas
authors.forename: V
authors.initials: V
authors.lastname: Campos
authors.forename: R
authors.initials: R
authors.lastname: Cámara
authors.forename: A
authors.initials: A
authors.lastname: Pérez-Lázaro
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003327:Coronary Disease / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians'; D011446:Prospective Studies; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D005947:Glucose; D006442:Glycated Hemoglobin