title: Caspase- and p38-MAPK-dependent induction of apoptosis in A549 lung cancer cells by Newcastle disease virus.
abstract: Newcastle disease virus (NDV) has a potential oncolytic effect due to its ability to induce apoptosis in tumor cells. However, previous studies have indicated discrepancies regarding the apoptosis signaling pathways induced by NDV in tumor cells. Here, we show that NDV infection induces simultaneous activation of intrinsic and extrinsic death pathways in A549 human lung cancer cells. In contrast, endoplasmic reticulum (ER) stress is not activated in NDV-induced apoptosis. We demonstrate for the first time that mitogen-activated protein kinase (MAPK) pathways are activated in NDV-infected A549 cells, and p38 MAPK is involved in NDV-induced cell death. Together, our findings provide novel insights into the underlying mechanisms by which NDV induces apoptosis in tumor cells.
authors.affiliation: National Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin, 150001, Heilongjiang, China.
authors.forename: Jianchun
authors.initials: J
authors.lastname: Bian
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Xiangang
authors.initials: X
authors.lastname: Kong
authors.forename: Huairan
authors.initials: H
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Maozhi
authors.initials: M
authors.lastname: Hu
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Zhang
authors.forename: Xinan
authors.initials: X
authors.lastname: Jiao
authors.forename: Baoxue
authors.initials: B
authors.lastname: Ge
authors.forename: Yantao
authors.initials: Y
authors.lastname: Wu
authors.forename: Songshu
authors.initials: S
authors.lastname: Meng
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D009522:Newcastle disease virus / Q000502:physiology*; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D048051:p38 Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D011065:Poly(ADP-ribose) Polymerases; D048051:p38 Mitogen-Activated Protein Kinases; D020169:Caspases