title: Antitubercular and fluorescence studies of copper(II) complexes with quinolone family member, ciprofloxacin.
abstract: Four new mixed-ligand complexes of Cu(II) with ciprofloxacin (Cip) and uninegative bidentate ligands have been synthesized and characterized. The structure of mixed-ligand complexes was investigated using spectroscopic method, physicochemical and elemental analyses. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation.
authors.affiliation: Shri R. R. Lalan College, Department of Chemistry, Bhuj, Gujarat, India. gaurangkharadi@yahoo.com
authors.forename: G J
authors.initials: GJ
authors.lastname: Kharadi
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005453:Fluorescence; D008958:Models, Molecular; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D010078:Oxazines; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013055:Spectrophotometry, Infrared; D014376:Tuberculosis / Q000188:drug therapy*; D014966:Xanthenes
chemical_list: D000995:Antitubercular Agents; D009942:Organometallic Compounds; D010078:Oxazines; D014966:Xanthenes; C005843:resazurin; D002939:Ciprofloxacin; D003300:Copper