title: Psoroptes cuniculi induced oxidative imbalance in rabbits and its alleviation by using vitamins A, D3, E, and H as adjunctive remedial.
abstract: The oxidant/antioxidant balance of rabbits naturally infected with Psoroptes cuniculi and treated with ivermectin +/- vitamins A, D(3), E, and H supplementation was investigated. Two groups of seven mixed ♂ and ♀, 6-to-8 month-old New Zealand White rabbits, diagnosed Psoroptes mites-positive by skin scraping examination and seven clinically healthy control rabbits were examined. Blood samples were obtained on day 0 and at 28 days post-therapy to determine oxidative stress indices. On day 0, the levels of lipid peroxides were significantly higher (P ≤ 0.01) in the Psoroptes-infected rabbits compared with the healthy controls while those of reduced glutathione and the activities of the antioxidant enzymes glutathione peroxidase, glutathione-S-transferase, catalase, and superoxide dismutase were significantly lower (P ≤ 0.01). Vitamin supplementation of the ivermectin-treated rabbits revealed both faster clinical (14 days) and parasitological (10 days) recovery. It was concluded that significant alteration of oxidant/antioxidant balance is a factor in the pathogenesis of P. cuniculi infestation of rabbits, and recovery can be enhanced by combining ivermectin treatment with vitamin A, D(3,) E, and H supplementation.
authors.affiliation: Division of Medicine, Indian Veterinary Research Institute, Izatnagar-243 122, Bareilly, UP, India. pshankervet@gmail.com
authors.forename: Shanker Kumar
authors.initials: SK
authors.lastname: Singh
authors.forename: Umesh
authors.initials: U
authors.lastname: Dimri
authors.forename: Mahesh Chandra
authors.initials: MC
authors.lastname: Sharma
authors.forename: Devendra
authors.initials: D
authors.lastname: Swarup
authors.forename: Mritunjay
authors.initials: M
authors.lastname: Kumar
authors.forename: Ramesh
authors.initials: R
authors.lastname: Tiwary
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000008:administration & dosage*; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000662:veterinary; D004338:Drug Combinations; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D018384:Oxidative Stress / Q000187:drug effects*; D040042:Psoroptidae / Q000187:drug effects*; D011817:Rabbits / Q000097:blood / Q000469:parasitology*; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000277:Adjuvants, Pharmaceutic; D000977:Antiparasitic Agents; D015415:Biomarkers; D004338:Drug Combinations; D014815:Vitamins; D007559:Ivermectin