title: Renal fibrosis and proteomics: current knowledge and still key open questions for proteomic investigation.
abstract: Renal tubulo-interstitial fibrosis is a non-specific process, representing the final common pathway for all kidney diseases, irrespective of their initial cause, histological injury, or etiology, leading to gradual expansion of the fibrotic mass which destroys the normal structure of the tissue and results in organ dysfunction and, ultimately, in end-stage organ failure. Proteomic studies of the fibrotic pathophysiological mechanisms have been performed in cell cultures, animal models and human tissues, addressing some of the key issues. This article will review proteomic contribution to the raising current knowledge on renal fibrosis biology and also mention seminal open questions to which proteomic techniques and proteomists could fruitfully contribute.
authors.affiliation: RenalChild Foundation, G. Gaslini Children Hospital, Genoa, Italy. marco.prunotto@gmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Prunotto
authors.forename: Gianmarco
authors.initials: G
authors.lastname: Ghiggeri
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bruschi
authors.forename: Giulio
authors.initials: G
authors.lastname: Gabbiani
authors.forename: Pierre
authors.initials: P
authors.lastname: Lescuyer
authors.forename: Berthold
authors.initials: B
authors.lastname: Hocher
authors.forename: Lyubov
authors.initials: L
authors.lastname: Chaykovska
authors.forename: Marco
authors.initials: M
authors.lastname: Berrera
authors.forename: Solange
authors.initials: S
authors.lastname: Moll
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000502:physiology; D016572:Cyclosporine / Q000009:adverse effects; D003928:Diabetic Nephropathies / Q000150:complications / Q000503:physiopathology; D005355:Fibrosis; D005921:Glomerulonephritis / Q000503:physiopathology; D006801:Humans; D000860:Hypoxia / Q000150:complications; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000473:pathology* / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D040901:Proteomics / Q000379:methods; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D001786:Blood Glucose; D016212:Transforming Growth Factor beta; D016572:Cyclosporine