title: Correlation of cerebral spinal fluid pH and HCO3- with disease progression in ALS.
abstract: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease, which is characterized by progressive degeneration of spinal and bulbar innervating motor neurons. However, the underlying mechanisms of motor neuron death remain poorly understood. Several candidate disease biomarkers have been detected in cerebrospinal fluid of ALS patients. The present study analyzed various cerebral spinal fluid gas parameters in ALS patients and compared these values to controls, as well as patients with cervical spondylosis, Parkinson syndrome, and spinocerebellar degeneration. Cerebral spinal fluid pH positively correlated with the ALS functional rating scale in total and limb-type ALS patients. In addition, cerebral spinal fluid pH positively correlated with shorter disease duration (less than 22 weeks). These results suggested that cerebral spinal fluid pH provides a biomarker for ALS and could reflect mechanisms of disease progression in ALS patients.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical science, Okayama University, Okayama, Japan.
authors.forename: Nobutoshi
authors.initials: N
authors.lastname: Morimoto
authors.forename: Kentaro
authors.initials: K
authors.lastname: Deguchi
authors.forename: Kota
authors.initials: K
authors.lastname: Sato
authors.forename: Taijun
authors.initials: T
authors.lastname: Yunoki
authors.forename: Shoko
authors.initials: S
authors.lastname: Deguchi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Ohta
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kurata
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Takao
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Tohru
authors.initials: T
authors.lastname: Matsuura
authors.forename: Koji
authors.initials: K
authors.lastname: Abe
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology; D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid* / Q000473:pathology*; D001639:Bicarbonates / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D016923:Cell Death / Q000502:physiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000134:cerebrospinal fluid / Q000473:pathology
chemical_list: D001639:Bicarbonates; D015415:Biomarkers