title: A nutritional intervention study with hydrolyzed collagen in pre-pubertal spanish children: influence on bone modeling biomarkers.
abstract: OBJECTIVE
  The aim of the study was to investigate the influence of dietary intake of commercial hydrolyzed collagen (Gelatine Royal) on bone remodeling in pre-pubertal children.
  
  
  METHODS
  A randomized double-blind study was carried out in 60 children (9.42 +/- 1.31 years) divided into three groups according to the amount of partially hydrolyzed collagen taken daily for 4 months: placebo (G-I, n=18), collagen (G-II, n=20) and collagen+calcium (G-III, n=22) groups. Analyses of the following biochemical markers were carried out: total and bone alkaline phosphatase (tALP and bALP), osteocalcin, tartrate-resistant acid phosphatase (TRAP), type I collagen carboxy-terminal telopeptide, lipids, calcium, 25-hydroxyvitamin D, insulin-like growth factor-1 (IGF-1), thyroid-stimulating hormone, free thyroxin and intact parathormone.
  
  
  RESULTS
  There was a significantly greater increase in serum IGF-1 in G-III than in G-II (p < 0.01) or G-I (p < 0.05) during the study period, and a significantly greater increase in plasma tALP in G-III than in G-I (p < 0.05). Serum bALP behavior significantly (p < 0.05) differed between G-II (increase) and G-I (decrease). Plasma TRAP behavior significantly differed between G-II and G-I (p < 0.01) and between G-III and G-II (p < 0.05).
  
  
  CONCLUSIONS
  Daily dietary intake of hydrolyzed collagen seems to have a potential role in enhancing bone remodeling at key stages of growth and development.
authors.affiliation: Department of Pediatrics, School of Medicine, University of Granada, Granada, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Martin-Bautista
authors.forename: Miguel
authors.initials: M
authors.lastname: Martin-Matillas
authors.forename: Jose A
authors.initials: JA
authors.lastname: Martin-Lagos
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Miranda-Leon
authors.forename: Manuel
authors.initials: M
authors.lastname: Muñoz-Torres
authors.forename: Estrella
authors.initials: E
authors.lastname: Ruiz-Requena
authors.forename: M
authors.initials: M
authors.lastname: Rivero
authors.forename: Josefa
authors.initials: J
authors.lastname: Quer
authors.forename: Isabel
authors.initials: I
authors.lastname: Puigdueta
authors.forename: Cristina
authors.initials: C
authors.lastname: Campoy
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000378:metabolism; D016723:Bone Remodeling / Q000187:drug effects* / Q000502:physiology; D002648:Child; D019963:Clinical Chemistry Tests; D024042:Collagen Type I / Q000008:administration & dosage*; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D006868:Hydrolysis; D008297:Male; D011627:Puberty; D013030:Spain
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D004044:Dietary Proteins; D000469:Alkaline Phosphatase