title: Genetic markers anticipate response to citalopram in a majority of patients.
abstract: OBJECTIVE
  Scientists have concluded that genetic profiles cannot predict a large percentage of variation in response to citalopram, a common antidepressant. Using the same data, we examined if a different conclusion can be arrived at when the results are personalized to fit specific patients.
  
  
  METHODS
  We used data available through the Sequenced Treatment Alternatives to Relieve Depression database. We created three boosted Classification and Regression Trees to identify 16 subgroups of patients, among whom anticipation of positive or negative response to citalopram was significantly different from 0.5 (P≤0.1).
  
  
  RESULTS
  In a 10-fold cross-validation, this ensemble of trees made no predictions in 33% of cases. In the remaining 67% of cases, it accurately classified response to citalopram in 78% of cases.
  
  
  CONCLUSIONS
  For the majority of the patients, genetic markers can be used to guide selection of citalopram. The rules identified in this study can help personalize prescription of antidepressants.
authors.affiliation: Department of Health Systems Administration, Washington VA Medical Center, Northwest, Washington, District of Columbia, USA. alemi@cox.net
authors.forename: Farrokh
authors.initials: F
authors.lastname: Alemi
authors.forename: Manaf
authors.initials: M
authors.lastname: Zargoush
authors.forename: Harold
authors.initials: H
authors.lastname: Erdman
authors.forename: Jee
authors.initials: J
authors.lastname: Vang
authors.forename: Steve
authors.initials: S
authors.lastname: Epstein
authors.forename: Fanous
authors.initials: F
authors.lastname: Ayman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D020132:Anticipation, Genetic; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015283:Citalopram / Q000627:therapeutic use*; D005819:Genetic Markers; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D005819:Genetic Markers; D015283:Citalopram