title: HIF-1α in epidermis: oxygen sensing, cutaneous angiogenesis, cancer, and non-cancer disorders.
abstract: Besides lung, postnatal human epidermis is the only epithelium in direct contact with atmospheric oxygen. Skin epidermal oxygenation occurs mostly through atmospheric oxygen rather than tissue vasculature, resulting in a mildly hypoxic microenvironment that favors increased expression of hypoxia-inducible factor-1α (HIF-1α). Considering the wide spectrum of biological processes, such as angiogenesis, inflammation, bioenergetics, proliferation, motility, and apoptosis, that are regulated by this transcription factor, its high expression level in the epidermis might be important to HIF-1α in skin physiology and pathophysiology. Here, we review the role of HIF-1α in cutaneous angiogenesis, skin tumorigenesis, and several skin disorders.
authors.affiliation: INSERM U1035, Bordeaux, France. hamidreza.rezvani@u-bordeaux2.fr
authors.forename: Hamid R
authors.initials: HR
authors.lastname: Rezvani
authors.forename: Nsrein
authors.initials: N
authors.lastname: Ali
authors.forename: Lars J
authors.initials: LJ
authors.lastname: Nissen
authors.forename: Ghida
authors.initials: G
authors.lastname: Harfouche
authors.forename: Hubert
authors.initials: H
authors.lastname: de Verneuil
authors.forename: Alain
authors.initials: A
authors.lastname: Taïeb
authors.forename: Frédéric
authors.initials: F
authors.lastname: Mazurier
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000503:physiopathology*; D004817:Epidermis / Q000502:physiology*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism; D012871:Skin Diseases / Q000378:metabolism / Q000503:physiopathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000503:physiopathology*
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D010100:Oxygen