title: [MET: new target, new combinations].
abstract: The MET tyrosine-kinase receptor is implicated in embryonic development and tissue repair. It appears to be a key of tumour development since it drives cell migration and invasion and can induce the conversion from an epithelial to a mesenchymal phenotype. Aberrant signaling of the MET pathways is associated with an aggressive prognosis and a poor outcome. Preliminary clinical results of several MET inhibitors have been encouraging particularly in tumours in which MET was amplified or mutated. MET inhibition could be especially interesting in association with others drugs since activation of MET is a secondary event induced by hypoxia, inflammatory cytokines or HER inhibitors that could exacerbate the malignant properties of transformed cells. Molecular targeted therapies against MET could therefore be effective as a combination approach.
authors.affiliation: Hôpital Saint-Louis, service d'oncologie médical, Paris, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Serrate
authors.forename: Sarah
authors.initials: S
authors.lastname: Watson
authors.forename: Stéphane
authors.initials: S
authors.lastname: Vignot
mesh_terms: D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D047428:Protein Kinase Inhibitors; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D019859:Proto-Oncogene Proteins c-met / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000502:physiology; D020239:Receptor Cross-Talk / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D047428:Protein Kinase Inhibitors; D011956:Receptors, Cell Surface; D011505:Protein-Tyrosine Kinases; D019859:Proto-Oncogene Proteins c-met