title: Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt.
abstract: Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed-Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: nodular sclerosis, 58%; mixed cellularity, 100%; lymphocyte depletion, 100%; and unclassifiable, 67%. Our findings are similar to those from other developing countries and point towards a pathogenic role of EBV in cHL.
authors.forename: Josée
authors.initials: J
authors.lastname: Audouin
authors.forename: Jacques
authors.initials: J
authors.lastname: Diebold
authors.forename: Bharat
authors.initials: B
authors.lastname: Nathwani
authors.forename: Elia
authors.initials: E
authors.lastname: Ishak
authors.forename: Kenneth
authors.initials: K
authors.lastname: Maclennan
authors.forename: Hans Konrad
authors.initials: HK
authors.lastname: Mueller-Hermelink
authors.forename: James O
authors.initials: JO
authors.lastname: Armitage
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Weisenburger