title: Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.
abstract: OBJECTIVE
  The associations between adiponectin polymorphisms and type 2 diabetes have been studied widely; however, results are inconsistent.
  
  
  METHODS
  We searched electronic literature databases and reference lists of relevant articles. A fixed or random effects model was used on the basis of heterogeneity. Sub-group and meta-regression analyses were conducted to explore the sources of heterogeneity.
  
  
  RESULTS
  There were no statistically significant associations between +45T>G (rs2241766), +276G>T (rs1501299), -11391G>A (rs17300539) and type 2 diabetes risk. However, for -11377C>G (rs266729), the pooled OR (95% CI) for G vs C allele was 1.07 (1.03-1.11, p = 0.001). Subgroup analysis by study design revealed that -11377C>G (rs266729) dominant model (CG+GG vs CC, p = 0.0008) and G vs C allele (p = 0.0004) might be associated with type 2 diabetes risk in population-based case-control studies. After stratification by ethnicity, we found that -11377C>G (rs266729) dominant model (CG+GG vs CC, p = 0.004) and G vs C allele (p = 0.001) might be associated with type 2 diabetes risk in white individuals. In individuals with a family history of diabetes, the presence of -11391G>A (rs17300539) dominant model (GA+AA vs GG) and A vs G allele might be associated with increased risk of type 2 diabetes.
  
  
  CONCLUSIONS
  The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes. However, G vs C allele of -11377C>G (rs266729) might be a risk factor for type 2 diabetes.
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, Heilongjiang 150081, People's Republic of China.
authors.forename: L Y
authors.initials: LY
authors.lastname: Han
authors.forename: Q H
authors.initials: QH
authors.lastname: Wu
authors.forename: M L
authors.initials: ML
authors.lastname: Jiao
authors.forename: Y H
authors.initials: YH
authors.lastname: Hao
authors.forename: L B
authors.initials: LB
authors.lastname: Liang
authors.forename: L J
authors.initials: LJ
authors.lastname: Gao
authors.forename: D G
authors.initials: DG
authors.lastname: Legge
authors.forename: H
authors.initials: H
authors.lastname: Quan
authors.forename: M M
authors.initials: MM
authors.lastname: Zhao
authors.forename: N
authors.initials: N
authors.lastname: Ning
authors.forename: Z
authors.initials: Z
authors.lastname: Kang
authors.forename: H
authors.initials: H
authors.lastname: Sun
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000483:Alleles; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D052242:Adiponectin