title: The effects of repetitious topical use of mitomycin C on antrostomy patency in maxillary antrostomy created rabbit model.
abstract: The aim of our study was to investigate the effect of the topical use of mitomycin C (MMC) intraoperatively in single dose and intra-postoperatively in two doses on the narrowing of antrostomy in maxillary rabbit sinus antrostomies created experimentally. And also to determine the local and systemic side effects of topical MMC. With this objective, 0.6 mg/ml MMC was used to the first group at single dose and to the second group intraoperatively and on third day postoperatively in two doses topically for 5 min. After 8 weeks, although the mean area of antrostomy was larger than that in the control side in the first group, which received single dose MMC, the difference was not statistically significant (p = 0.287). The second group received two doses, and the antrostomy areas were found to be significantly larger than the controls (p = 0.05). Overall, the sides that received MMC were significantly larger (p = 0.029). From the point of histopathological examination of the tissue, it was seen that two-dose MMC increased the edema indicating inflammation and antrostomy resolved with normal respiratory tract epithelium. It was shown by measuring the blood values that nephrotoxic and myelosupressant effect of MMC occurring in systemic use did not occur with single or double dose topical use. Our results demonstrate that even if the number of cases was low, two doses of topical MMC usage prevent the narrowing of antrostomy while single dose MMC does not. And two-dose topical MMC usage does not have local and systemic side effects.
authors.affiliation: Department of Otorhinolaryngology, Ministry of Health Polatli State Hospital, Hasan Polatkan Street, Polatli, Ankara, Turkey. akavuzlu@hotmail.com
authors.forename: Ali
authors.initials: A
authors.lastname: Kavuzlu
authors.forename: Necmi
authors.initials: N
authors.lastname: Arslan
authors.forename: Eren
authors.initials: E
authors.lastname: Tastan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Islam
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ustun
authors.forename: Filiz
authors.initials: F
authors.lastname: Aydogan
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D007432:Intraoperative Period; D008443:Maxillary Sinus / Q000601:surgery*; D016685:Mitomycin / Q000008:administration & dosage*; D015508:Nasal Obstruction / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D010254:Paranasal Sinus Diseases / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D011184:Postoperative Period; D011817:Rabbits; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin