title: Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.
abstract: BACKGROUND
  Major depressive disorder (MDD) is a universally prevalent, genetic, and environment dependent mental condition that disables people of every culture, race, gender, and age. While the gender differences for MDD have been widely reported in literature, few genome-wide analyses of gender differences have been reported to date.
  
  
  METHODS
  We conducted a genome-wide association analysis of gender differences for MDD using the Netherlands NESDA and NTR population-based samples (1726 cases and 1630 controls). PLINK software was used to analyze the genome-wide association data of Perlegen 600 K SNP Chips.
  
  
  RESULTS
  We identified 40 male-specific and 56 female-specific MDD associated SNPs with P-values less than 10(-4). The best male-specific SNP was rs9352774 (P=2.26 × 10(-6)) within LGSN gene while the best female-specific SNP was rs2715148 (P=5.64 × 10(-7)) within PCLO gene. We also found 38 SNPs showing gene × gender interactions in influencing MDD (P<10(-4)). The best SNP was rs12692709 (P=5.75 × 10(-6)) near FIGN gene at 2q24.3 while the next best SNP was rs11039588 (P=1.16 × 10(-5)) within OR4B1 gene.
  
  
  CONCLUSIONS
  The findings from this study need be replicated in other populations.
  
  
  CONCLUSIONS
  These results provide genetic basis for gender differences in MDD and will serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in MDD.
authors.affiliation: Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Nagesh
authors.initials: N
authors.lastname: Aragam
authors.forename: Ke-Sheng
authors.initials: KS
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Pan
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D003598:Cytoskeletal Proteins / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D005974:Glutamate-Ammonia Ligase / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D009479:Neuropeptides / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012727:Sex Characteristics
chemical_list: D003598:Cytoskeletal Proteins; D009479:Neuropeptides; C498630:PCLO protein, human; D005974:Glutamate-Ammonia Ligase; C507977:LGSN protein, human