title: Interleukin-17 and interleukin-18 levels in saliva and plasma of patients with chronic periodontitis.
abstract: OBJECTIVE
  This study was planned to investigate whether patients with chronic periodontitis exhibit different salivary and/or plasma concentrations of interleukin (IL)-17 and IL-18 compared with clinically healthy subjects.
  
  
  METHODS
  Whole saliva and blood samples, together with full-mouth clinical periodontal recordings, were obtained from 22 otherwise healthy untreated nonsmokers with chronic periodontitis and from 21 systemically and periodontally healthy control subjects. The concentrations of IL-17 and IL-18 in saliva and plasma were determined using ELISAs.
  
  
  RESULTS
  The healthy control group exhibited significantly lower values in all clinical periodontal measurements (p < 0.001). The salivary concentration of IL-17 was significantly lower, and that of IL-18 significantly higher, in patients from the chronic periodontitis group compared with healthy control subjects (p = 0.025 and p = 0.009, respectively). Plasma IL-17 and IL-18 concentrations were similar in the two study groups (p > 0.05).
  
  
  CONCLUSIONS
  Within the limits of the present study, it may be suggested that an elevated salivary IL-18 level in untreated nonsmoker chronic periodontitis patients has the potential to be a biomarker for periodontal tissue destruction.
authors.affiliation: Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Ozçaka
authors.forename: A
authors.initials: A
authors.lastname: Nalbantsoy
authors.forename: N
authors.initials: N
authors.lastname: Buduneli
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000032:analysis* / Q000097:blood; D020382:Interleukin-18 / Q000032:analysis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis
chemical_list: D015415:Biomarkers; D020381:Interleukin-17; D020382:Interleukin-18; D012471:Salivary Proteins and Peptides