title: Analgesic effect of Anatolian propolis in mice.
abstract: OBJECTIVE
  The aim of the present study was to assess the analgesic effect of Anatolian propolis, which is added to toothpastes as a prophylactic component for periodontal diseases.
  
  
  METHODS
  Water-, ethanol- and acetone-extracted Anatolian propolis were prepared. The analgesic effect of the extracts was assessed using the tail-flick test in mice (n=6 per extract). Comparison among groups was made using one-way ANOVA, followed by post-hoc Scheffe test to determine significant differences among the means of the data groups. P<0.05 was accepted as indicating a significant difference.
  
  
  RESULTS
  We found that water-extracted Anatolian propolis caused a significant increase, 1.61-fold (p<0.001 versus control), in the latency time using tail-flick test in mice. However, acetone-extracted and ethanol-extracted propolis led to no significant effect.
  
  
  CONCLUSIONS
  We proved the analgesic effect of water-extracted Anatolian propolis. Thus, propolis used in the composition of toothpastes may be beneficial in terms of its analgesic action in addition to its other favorable effects.
authors.affiliation: Department of Dentomaxillofacial Radiology, Ankara University, Faculty of Dentistry, Ankara, Turkey. dtkivo@yahoo.com
authors.forename: Kıvanç
authors.initials: K
authors.lastname: Kamburoğlu
authors.forename: Tuncer
authors.initials: T
authors.lastname: Özen
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051379:Mice; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D010510:Periodontal Diseases / Q000188:drug therapy / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011429:Propolis / Q000008:administration & dosage / Q000494:pharmacology*; D014100:Toothpastes; D014421:Turkey
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D014100:Toothpastes; D011429:Propolis