title: Chemical composition and biological activity of Laennecia schiedeana.
abstract: The chemical study of Laennecia schiedeana afforded three sterols, five diterpenes, five flavonoids, three caffeoyl derivatives of quinic acid, and two triterpenes. Evaluation of the cytotoxic activity of the extracts and isolated metabolites showed that 15-methoxy-16-oxo-15,16H-strictic acid was the most active compound [(15.05 +/- 2.2) microg/mL against U-251 cells]. In antibacterial assays the acetonic extract of leaves was the only active extract exhibiting its highest effect against the multiresistant Staphylococcus epidermidis (MIC 0.25 mg/mL). The anti-inflammatory activity observed was mild in the extracts and not relevant in the isolated compounds.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 México, DF México.
authors.forename: Amira
authors.initials: A
authors.lastname: Arciniegas
authors.forename: Luis Angel
authors.initials: LA
authors.lastname: Polindara
authors.forename: Ana L
authors.initials: AL
authors.lastname: Pérez-Castorena
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: García
authors.forename: Guillermo
authors.initials: G
authors.lastname: Avila
authors.forename: José Luis
authors.initials: JL
authors.lastname: Villaseñor
authors.forename: Alfonso Romo
authors.initials: AR
authors.lastname: de Vivar
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D011801:Quinic Acid / Q000302:isolation & purification* / Q000494:pharmacology; D013261:Sterols / Q000302:isolation & purification* / Q000494:pharmacology; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D013261:Sterols; D013729:Terpenes; D011801:Quinic Acid