title: Vasorelaxant effects of macrocyclic bis(bibenzyls) from liverworts.
abstract: Vasorelaxant effects of a series of bis(bibenzyls) from liverworts such as Marchantia polymorpha and Marchantia paleacea on rat aorta demonstrated that they relaxed phenylephrine (PE)-induced contractions, which may be mediated through the increased release of NO from endothelial cells as well as opening of K(+) channels, and inhibition of Ca(2+) influx through voltage-dependent Ca(2+) channels (VDCs) and/or receptor-operated Ca(2+) channels (ROCs). Structure-activity relationship based on their structures was discussed. The presence of two aromatic rings which can be connected through two atoms bridge spacer may play an important role for vasorelaxant effect.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. moritah@hoshi.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Zaima
authors.forename: Ikumi
authors.initials: I
authors.lastname: Koga
authors.forename: Aiko
authors.initials: A
authors.lastname: Saito
authors.forename: Haruka
authors.initials: H
authors.lastname: Tamamoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Okazaki
authors.forename: Toshio
authors.initials: T
authors.lastname: Kaneda
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D000818:Animals; D001011:Aorta / Q000166:cytology; D001632:Bibenzyls / Q000737:chemistry*; D015220:Calcium Channels / Q000737:chemistry / Q000378:metabolism; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects; D035926:Hepatophyta / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014665:Vasodilator Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D001632:Bibenzyls; D015220:Calcium Channels; D047028:Macrocyclic Compounds; D014665:Vasodilator Agents; D009569:Nitric Oxide