title: Discrete regulatory regions control early and late expression of D-Pax2 during external sensory organ development.
abstract: The transcription factor D-Pax2 is required for the correct differentiation of several cell types in Drosophila sensory systems. While the regulation of its expression in the developing eye has been well studied, little is known about the mechanisms by which the dynamic pattern of D-Pax2 expression in the external sensory organs is achieved. Here we demonstrate that early activation of D-Pax2 in the sensory organ lineage and its maintenance in the trichogen and thecogen cells are governed by separate enhancers. Furthermore, the initial activation is controlled in part by proneural proteins whereas the later maintenance expression is regulated by a positive feedback loop.
authors.affiliation: Department of Biology, Colby College, Waterville, Maine, USA.
authors.forename: Seth A
authors.initials: SA
authors.lastname: Johnson
authors.forename: Katharine J
authors.initials: KJ
authors.lastname: Harmon
authors.forename: Sarah G
authors.initials: SG
authors.lastname: Smiley
authors.forename: Frances M
authors.initials: FM
authors.lastname: Still
authors.forename: Joshua
authors.initials: J
authors.lastname: Kavaler
mesh_terms: D000818:Animals; D004330:Drosophila / Q000196:embryology* / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D007150:Immunohistochemistry; D051762:PAX2 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000166:cytology / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D051762:PAX2 Transcription Factor