title: Serum intestinal fatty acid binding protein level for early diagnosis and prediction of severity of necrotizing enterocolitis.
abstract: OBJECTIVE
  Intestinal fatty acid binding protein (I-FABP) is found within cells at the tip of the intestinal villi, an area commonly injured in necrotizing enterocolitis (NEC). In this study, we aimed to investigate the value of serum I-FABP in early diagnosis and predicting severity of NEC.
  
  
  METHODS
  This prospective study was conducted between April 2009 and November 2009. The preterm infants with suspected NEC were included in the study. These infants were divided into two groups according to their final diagnoses; Group 1: Stage 1 NEC and Group 2: Stages 2-3 NEC (Group 2a: Stage 2 NEC, Group 2b: Stage 3 NEC). Healthy preterms were assigned to control group (Group 3). Serial blood samples were obtained from the patients at symptom onset, 24h and 72 h later. One blood sample was taken from the controls. Serum I-FABP levels were compared among the groups.
  
  
  RESULTS
  Initial serum I-FABP concentrations were 324.0±165.8 pg/ml, 764.7±465.1 pg/ml, and 360.2±439.5 pg/ml in Group 1, Group 2a, and Group 2b, respectively, and all were significantly higher than those of the control group (76.9±115.9 pg/ml) (p<0.001). The serum I-FABP levels gradually decreased from the onset of the disease to 72nd hour in Group 1 and Group 2a (p=0.001). In Group 2b I-FABP concentrations slightly decreased at 24th hour of the disease and increased thereafter, but the difference was not significant (p=0.06).
  
  
  CONCLUSIONS
  Serial measurements of I-FABP levels may be a useful marker for early diagnosis and prediction of disease severity in NEC.
authors.affiliation: Department of Neonatology, Zekai Tahir Burak Maternity Hospital, Ankara, Turkey. chaydemir@hotmail.com
authors.forename: Cumhur
authors.initials: C
authors.lastname: Aydemir
authors.forename: Dilek
authors.initials: D
authors.lastname: Dilli
authors.forename: Serife Suna
authors.initials: SS
authors.lastname: Oguz
authors.forename: Hulya Ozkan
authors.initials: HO
authors.lastname: Ulu
authors.forename: Nurdan
authors.initials: N
authors.lastname: Uras
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.forename: Ugur
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D042241:Early Diagnosis; D020345:Enterocolitis, Necrotizing / Q000097:blood / Q000175:diagnosis*; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood / Q000175:diagnosis*; D008297:Male
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins