title: The role of macrophage colony-stimulating factor in patients with acute myocardial infarction: a pilot study.
abstract: We assessed whether macrophage colony-stimulating factor (M-CSF) levels are associated with left ventricular systolic dysfunction (LVSD) in patients with acute myocardial infarction (AMI). We studied 56 patients with AMI (mean age: 67 ± 12 years) and identified those with clinical (Killip class >II) or echocardiographic signs (ejection fraction ≤45%) of LVSD. We evaluated the established cardiovascular risk factors and measured several cardiovascular biomarkers, including M-CSF. Serum M-CSF concentrations (pg/mL) were significantly increased in patients with both clinical and echocardiographic signs of LVSD (460 ± 265 vs 290 ± 210, P = .0103 and 493 ± 299 vs 287 ± 174, P = .0028, respectively). We found a significant inverse association between M-CSF and ejection fraction (r = -.351, P = .0079). Logistic regression analysis revealed that, among all evaluated clinical and biochemical parameters, the stronger predictor of LVSD was M-CSF (odds ratios 2.1, 95% confidence interval 1.1-2.9, P = .0168). This is the first study reporting plasma M-CSF levels as independent determinants of low LV ejection fraction and clinical LV dysfunction in patients with AMI.
authors.affiliation: Department of Internal Medicine and Medical Specialties, University of Palermo, Via del Vespro 129, Palermo, Italy. novog@unipa.it
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Novo
authors.forename: Manfredi
authors.initials: M
authors.lastname: Rizzo
authors.forename: Salvatore
authors.initials: S
authors.lastname: La Carruba
authors.forename: Marco
authors.initials: M
authors.lastname: Caruso
authors.forename: Gisella Rita
authors.initials: GR
authors.lastname: Amoroso
authors.forename: Carmela Rita
authors.initials: CR
authors.lastname: Balistreri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Coppola
authors.forename: Giovanna
authors.initials: G
authors.lastname: Evola
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
authors.forename: Pasquale
authors.initials: P
authors.lastname: Assennato
authors.forename: Salvatore
authors.initials: S
authors.lastname: Novo
authors.forename: Dario
authors.initials: D
authors.lastname: Mancuso
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications*; D010865:Pilot Projects; D011237:Predictive Value of Tests; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000209:etiology*
chemical_list: D015415:Biomarkers; D016173:Macrophage Colony-Stimulating Factor