title: International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations.
abstract: Recombinant adenovirus serotype 5 (rAd5) vaccine vectors for HIV-1 and other pathogens have been shown to be limited by high titers of Ad5 neutralizing antibodies (NAbs) in the developing world. Alternative serotype rAd vectors have therefore been constructed. Here we report Ad5, Ad26, Ad35, and Ad48 NAb titers in 4381 individuals from North America, South America, sub-Saharan Africa, and Southeast Asia. As expected, Ad5 NAb titers were both frequent and high magnitude in sub-Saharan Africa and Southeast Asia. In contrast, Ad35 NAb titers proved infrequent and low in all regions studied, and Ad48 NAbs were rare in all regions except East Africa. Ad26 NAbs were moderately common in adults in sub-Saharan Africa and Southeast Asia, but Ad26 NAb titers proved markedly lower than Ad5 NAb titers in all regions, and these relatively low Ad26 NAb titers did not detectably suppress the immunogenicity of 4×10(10)vp of a rAd26-Gag/Pol/Env/Nef vaccine in rhesus monkeys. These data inform the clinical development of alternative serotype rAd vaccine vectors in the developing world.
authors.affiliation: Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. dbarouch@bidmc.harvard.edu
authors.forename: Dan H
authors.initials: DH
authors.lastname: Barouch
authors.forename: Sandra V
authors.initials: SV
authors.lastname: Kik
authors.forename: Gerrit J
authors.initials: GJ
authors.lastname: Weverling
authors.forename: Rebecca
authors.initials: R
authors.lastname: Dilan
authors.forename: Sharon L
authors.initials: SL
authors.lastname: King
authors.forename: Lori F
authors.initials: LF
authors.lastname: Maxfield
authors.forename: Sarah
authors.initials: S
authors.lastname: Clark
authors.forename: David
authors.initials: D
authors.lastname: Ng'ang'a
authors.forename: Kara L
authors.initials: KL
authors.lastname: Brandariz
authors.forename: Peter
authors.initials: P
authors.lastname: Abbink
authors.forename: Faruk
authors.initials: F
authors.lastname: Sinangil
authors.forename: Guy
authors.initials: G
authors.lastname: de Bruyn
authors.forename: Glenda E
authors.initials: GE
authors.lastname: Gray
authors.forename: Surita
authors.initials: S
authors.lastname: Roux
authors.forename: Linda-Gail
authors.initials: LG
authors.lastname: Bekker
authors.forename: Athmanundh
authors.initials: A
authors.lastname: Dilraj
authors.forename: Hannah
authors.initials: H
authors.lastname: Kibuuka
authors.forename: Merlin L
authors.initials: ML
authors.lastname: Robb
authors.forename: Nelson L
authors.initials: NL
authors.lastname: Michael
authors.forename: Omu
authors.initials: O
authors.lastname: Anzala
authors.forename: Pauli N
authors.initials: PN
authors.lastname: Amornkul
authors.forename: Jill
authors.initials: J
authors.lastname: Gilmour
authors.forename: John
authors.initials: J
authors.lastname: Hural
authors.forename: Susan P
authors.initials: SP
authors.lastname: Buchbinder
authors.forename: Michael S
authors.initials: MS
authors.lastname: Seaman
authors.forename: Raphael
authors.initials: R
authors.lastname: Dolin
authors.forename: Lindsey R
authors.initials: LR
authors.lastname: Baden
authors.forename: Angela
authors.initials: A
authors.lastname: Carville
authors.forename: Keith G
authors.initials: KG
authors.lastname: Mansfield
authors.forename: Maria G
authors.initials: MG
authors.lastname: Pau
authors.forename: Jaap
authors.initials: J
authors.lastname: Goudsmit
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D000256:Adenoviridae / Q000276:immunology* / Q000302:isolation & purification; D000257:Adenoviridae Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology* / Q000821:virology; D000293:Adolescent; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D002648:Child; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007223:Infant; D008253:Macaca mulatta / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D055815:Young Adult
chemical_list: D016915:AIDS Vaccines; D000914:Antibodies, Viral; D014614:Vaccines, Synthetic; D014765:Viral Vaccines