title: Xenotransplantation of cryopreserved ovarian tissue from patients with ovarian tumors into SCID mice--no evidence of malignant cell contamination.
abstract: This study examined the possible presence of malignant cells in ovarian cortex from patients with ovarian tumors after xenografting of the ovarian tissue into severe combined immunodeficiency mice. None of the mice presented symptoms of reintroduced malignancy nor did microscopic and immunohistochemical evaluation of the grafts raise any suspicion of residual malignant disease.
authors.affiliation: Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Lotz
authors.forename: Markus
authors.initials: M
authors.lastname: Montag
authors.forename: Hans
authors.initials: H
authors.lastname: van der Ven
authors.forename: Michael
authors.initials: M
authors.lastname: von Wolff
authors.forename: Andreas
authors.initials: A
authors.lastname: Mueller
authors.forename: Inge
authors.initials: I
authors.lastname: Hoffmann
authors.forename: David
authors.initials: D
authors.lastname: Wachter
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Beckmann
authors.forename: Ralf
authors.initials: R
authors.lastname: Dittrich
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D016513:Mice, SCID; D009334:Neck Muscles / Q000473:pathology / Q000601:surgery*; D009366:Neoplasm Seeding; D018365:Neoplasm, Residual; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery*; D010053:Ovary / Q000473:pathology / Q000637:transplantation*; D013997:Time Factors; D014183:Transplantation, Heterologous / Q000009:adverse effects; D055815:Young Adult