title: Effectiveness of the whole-cell pertussis vaccine produced in Poland against different Bordetella parapertussis isolates in the mouse intranasal challenge model.
abstract: The aim of the study was to evaluate the effectiveness of the whole-cell pertussis vaccine produced locally and routinely used in Poland in the elimination of Bordetella parapertussis strains from the lungs and trachea of a mouse model. We found that the average protective effect against B. parapertussis in the lungs of mice immunized with the whole-cell pertussis vaccine (DTwP) was significantly higher than in animals immunized with the acellular pertussis vaccine (DTaP). The effectiveness of B. parapertussis elimination rates from the lungs of DTwP-immunized mice, depending on the strain used as a challenge, was found to be 1.2-3.0 times or 3.1-7.0 times lower than against Bordetella. pertussis Tohama I or vaccine B. pertussis 606/67 isolates, respectively. Our results show that the locally produced DTwP vaccine is able to protect against B. parapertussis isolates; however, the level of protection and course of B. parapertussis infection in the lungs and trachea seems to be strain specific.
authors.affiliation: Department of Sera and Vaccines Evaluation, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Zawadka
authors.forename: Maciej
authors.initials: M
authors.lastname: Polak
authors.forename: Daniel
authors.initials: D
authors.lastname: Rabczenko
authors.forename: Ewa
authors.initials: E
authors.lastname: Mosiej
authors.forename: Ewa
authors.initials: E
authors.lastname: Augustynowicz
authors.forename: Anna
authors.initials: A
authors.lastname: Lutyńska
mesh_terms: D000818:Animals; D001885:Bordetella Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D042483:Bordetella parapertussis / Q000276:immunology*; D001886:Bordetella pertussis / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D008168:Lung / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D011044:Poland; D012376:Rodent Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D014132:Trachea / Q000382:microbiology
chemical_list: D010567:Pertussis Vaccine