title: Peyronie's disease: review of nonsurgical treatment options.
abstract: The purpose of this article is to review the contemporary literature on nonsurgical therapies for Peyronie's disease (PD); focus on randomized, placebo-controlled trials; and review the latest guidelines for the management of PD from the International Consultation on Sexual Medicine. A combination of oral agents or intralesional injection with traction therapy may provide a synergy between the chemical effects of the drugs and the mechanical effects of traction. Until a reliable treatment emerges, some of the nonsurgical treatments discussed can be used to stabilize the scarring process and may result in some reduction of deformity with improved sexual function.
authors.affiliation: Department of Urology, Rush University Medical Center, 1725 West Harrison Street, Suite 352, Chicago, IL 60612, USA.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Larsen
authors.forename: Laurence A
authors.initials: LA
authors.lastname: Levine
mesh_terms: D010129:4-Aminobenzoic Acid / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002331:Carnitine / Q000627:therapeutic use; D003078:Colchicine / Q000627:therapeutic use; D017364:Collagenases / Q000627:therapeutic use; D003131:Combined Modality Therapy; D000075202:Contraindications; D004565:Electroconvulsive Therapy; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D007478:Iontophoresis; D008297:Male; D010411:Penile Induration / Q000628:therapy*; D010431:Pentoxifylline / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D013629:Tamoxifen / Q000627:therapeutic use; D014143:Traction; D014810:Vitamin E
chemical_list: D002121:Calcium Channel Blockers; D013629:Tamoxifen; D014810:Vitamin E; D007372:Interferons; D017364:Collagenases; D002331:Carnitine; D010431:Pentoxifylline; D003078:Colchicine; D010129:4-Aminobenzoic Acid