title: Crosstalk between viruses and PML nuclear bodies: a network-based approach.
abstract: Due to the recent advances in instrumental and scientific methods, cell biology data are generated with increasing speed and quantity. One of these fast developing fields is the crosstalk between promyelocytic leukemia protein nuclear bodies (PML-NBs) and viruses. PML-NBs are dynamic nuclear protein aggregates which are targeted by entire viral particles, viral proteins or viral nucleic acids. Their possible anti-viral properties motivated researchers to investigate the interaction between PML-NBs and viruses in depth. Based on extensive literature data mining, we created a comprehensive PML-NB/virus crosstalk Cytoscape network, which groups not only the most common relations but also less well described findings. The network is easy to navigate and provides a biologically relevant overview which can help finding interesting case studies.
authors.affiliation: Laboratory of Protein Science, Proteomics and Epigenetic Signal Transduction, Department of Biomedical Sciences, University of Antwerp (Campus Drie Eiken), Universiteitsplein 1, Building T, 2610 Wilrijk, Belgium.
authors.forename: Ellen
authors.initials: E
authors.lastname: Van Damme
authors.forename: Xaveer
authors.initials: X
authors.lastname: Van Ostade
mesh_terms: D006801:Humans; D007181:Inclusion Bodies, Viral / Q000378:metabolism* / Q000821:virology*; D045586:Intranuclear Inclusion Bodies / Q000378:metabolism* / Q000821:virology*; D015473:Leukemia, Promyelocytic, Acute / Q000378:metabolism* / Q000821:virology*; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000378:metabolism; D009696:Nucleic Acids / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; D009696:Nucleic Acids; D014764:Viral Proteins