title: g:Profiler--a web server for functional interpretation of gene lists (2011 update).
abstract: Functional interpretation of candidate gene lists is an essential task in modern biomedical research. Here, we present the 2011 update of g:Profiler (http://biit.cs.ut.ee/gprofiler/), a popular collection of web tools for functional analysis. g:GOSt and g:Cocoa combine comprehensive methods for interpreting gene lists, ordered lists and list collections in the context of biomedical ontologies, pathways, transcription factor and microRNA regulatory motifs and protein-protein interactions. Additional tools, namely the biomolecule ID mapping service (g:Convert), gene expression similarity searcher (g:Sorter) and gene homology searcher (g:Orth) provide numerous ways for further analysis and interpretation. In this update, we have implemented several features of interest to the community: (i) functional analysis of single nucleotide polymorphisms and other DNA polymorphisms is supported by chromosomal queries; (ii) network analysis identifies enriched protein-protein interaction modules in gene lists; (iii) functional analysis covers human disease genes; and (iv) improved statistics and filtering provide more concise results. g:Profiler is a regularly updated resource that is available for a wide range of species, including mammals, plants, fungi and insects.
authors.affiliation: University of Tartu, Institute of Computer Science, Tartu, Estonia. juri.reimand@ut.ee
authors.forename: Jüri
authors.initials: J
authors.lastname: Reimand
authors.forename: Tambet
authors.initials: T
authors.lastname: Arak
authors.forename: Jaak
authors.initials: J
authors.lastname: Vilo
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics; D020869:Gene Expression Profiling; D005796:Genes; D015894:Genome, Human; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D046912:Multiprotein Complexes / Q000032:analysis; D020641:Polymorphism, Single Nucleotide; D025941:Protein Interaction Mapping; D012984:Software
chemical_list: D046912:Multiprotein Complexes