title: On the fixation process of a beneficial mutation in a variable environment.
abstract: A population that adapts to gradual environmental change will typically experience temporal variation in its population size and the selection pressure. On the basis of the mathematical theory of inhomogeneous branching processes, we present a framework to describe the fixation process of a single beneficial allele under these conditions. The approach allows for arbitrary time-dependence of the selection coefficient s(t) and the population size N(t), as may result from an underlying ecological model. We derive compact analytical approximations for the fixation probability and the distribution of passage times for the beneficial allele to reach a given intermediate frequency. We apply the formalism to several biologically relevant scenarios, such as linear or cyclic changes in the selection coefficient, and logistic population growth. Comparison with computer simulations shows that the analytical results are accurate for a large parameter range, as long as selection is not very weak.
authors.affiliation: Mathematics and Biosciences Group, Faculty of Mathematics and Max F. Perutz Laboratories, University of Vienna, A-1090 Vienna, Austria. hildegard.uecker@univie.ac.at
authors.forename: Hildegard
authors.initials: H
authors.lastname: Uecker
authors.forename: Joachim
authors.initials: J
authors.lastname: Hermisson
mesh_terms: D000465:Algorithms; D000483:Alleles; D000818:Animals; D003198:Computer Simulation; D004777:Environment; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics*; D011156:Population Density; D011336:Probability; D012641:Selection, Genetic; D013997:Time Factors