title: Artomandin, a new xanthone from Artocarpus kemando (Moraceae).
abstract: A new furanodihydrobenzoxanthone, artomandin (1), together with three other flavonoid derivatives, artoindonesianin C, artonol B, and artochamin A, as well as β-sitosterol were isolated from the stem bark of Artocarpus kemando. The structures of these compounds were determined on the basis of spectral evidence. All of these compounds displayed inhibition effects to a very susceptible degree in cancer cell line tests. Compound 1 also exhibited significant antioxidant capacity in the free radical 1,1-diphenyl-2-picrylhydrazyl tests.
authors.affiliation: Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. gwen@science.upm.edu.my
authors.forename: Gwendoline Cheng Lian
authors.initials: GC
authors.lastname: Ee
authors.forename: Siow Hwa
authors.initials: SH
authors.lastname: Teo
authors.forename: Mawardi
authors.initials: M
authors.lastname: Rahmani
authors.forename: Chan Kiang
authors.initials: CK
authors.lastname: Lim
authors.forename: Yang Mooi
authors.initials: YM
authors.lastname: Lim
authors.forename: Rusea
authors.initials: R
authors.lastname: Go
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D031622:Artocarpus / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D044004:Xanthones; C561205:artomandin