title: Comparison of reproductive toxicity caused by cisplatin and novel platinum-N-heterocyclic carbene complex in male rats.
abstract: Cisplatin and other platinum complexes are important chemotherapeutic agents and useful in the treatment for several cancers such as prostate, ovarian and testis. However, severe side effects including reproductive toxicity of cisplatin and other platinum complex cause limitations in their clinical usage. In this context, we aimed to compare the damage in testis caused by cisplatin and a novel platinum-N-heterocyclic carbene complex (Pt-NHC). To this end, 35 Sprague-Dawley rats were divided randomly into five equal groups (n = 7 in each group). Cisplatin and Pt-NHC were intraperitoneally administered as a single dose of 5 mg/kg or 10 mg/kg, and the rats were then killed 10 days after this treatment. The testicular tissues and serum samples were taken from all rats for the determination of reproductive toxicity. The results showed that cisplatin and Pt-NHC caused toxicity on the reproductive system via increased oxidative and histological damage, decreased serum testosterone levels and negatively altered sperm characteristics in a dose-dependent manner (p < 0.05). At the same dose levels, cisplatin generally caused lower toxicity on the reproductive system compared with Pt-NHC. In conclusion, these results suggest that Pt-NHC has more toxic effects on the male reproductive system than cisplatin, and in terms of clinical usage, Pt-NHC may be unsafe compared with cisplatin.
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Inonu, Malatya, Turkey. osmciftci@gmail.com
authors.forename: Osman
authors.initials: O
authors.lastname: Ciftci
authors.forename: Ali
authors.initials: A
authors.lastname: Beytur
authors.forename: Oguz
authors.initials: O
authors.lastname: Cakir
authors.forename: Nevin
authors.initials: N
authors.lastname: Gurbuz
authors.forename: Nigar
authors.initials: N
authors.lastname: Vardi
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000633:toxicity*; D008297:Male; D009944:Organoplatinum Compounds / Q000633:toxicity*; D017671:Platinum Compounds / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
chemical_list: D016588:Anticarcinogenic Agents; D009944:Organoplatinum Compounds; D017671:Platinum Compounds; C569970:Pt-NHC complex; D013739:Testosterone; D002945:Cisplatin