title: Renal nerves, WNK4, glucocorticoids, and salt transport.
abstract: Roles of the sympathetic nervous system versus kidney salt transporters in hypertension are debated. A study in Nature Medicine (Mu et al., 2011) shows that dietary salt excess, coupled with β-adrenergic stimulation, increases arterial pressure via glucocorticoid receptors and WNK4, suggesting interactions between these systems in the pathogenesis of hypertension.
authors.affiliation: Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239, USA. ellisond@ohsu.edu
authors.forename: David H
authors.initials: DH
authors.lastname: Ellison
authors.forename: Virginia L
authors.initials: VL
authors.lastname: Brooks