title: Are water vole resistant to anticoagulant rodenticides following field treatments?
abstract: The anti-vitamin Ks (AVKs) are widely used to control rodent populations. They inhibit Vitamin K regeneration by the Vitamin K Epoxide Reductase (VKOR) and cause a fatal hemorrhagic syndrome. Because of repeated use, some populations of commensal rodents have expressed resistance to these compounds. In Franche-Comté (France), the water vole exhibits cyclic population outbreaks. A second generation AVK, bromadiolone, has been used for the last 20 years to control vole populations. The aim of this study is to determine whether these repeated treatments could have led to the development of resistance to AVKs in water vole populations. We conducted enzymatic and genetic studies on water voles trapped in treated and non treated plot. The results indicate that voles from the most heavily treated area exhibit enzymatic changes in VKOR activity hence arguing for resistance to AVKs and that an intronic haplotype on the vkorc1 gene seems to be associated with these enzymatic changes.
authors.affiliation: UMR 1233 INRA, VetAgro Sup, VetAgro Sup Campus Vétérinaire de Lyon 1 Avenue Bourgelat, 69280, Marcy L'Etoile, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Vein
authors.forename: Agnès
authors.initials: A
authors.lastname: Grandemange
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cosson
authors.forename: Etienne
authors.initials: E
authors.lastname: Benoit
authors.forename: Philippe J
authors.initials: PJ
authors.lastname: Berny
mesh_terms: D015110:4-Hydroxycoumarins / Q000633:toxicity*; D000222:Adaptation, Physiological; D000818:Animals; D000925:Anticoagulants / Q000633:toxicity*; D003411:Arvicolinae / Q000378:metabolism / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000235:genetics / Q000378:metabolism; D012378:Rodenticides / Q000633:toxicity*; D064417:Vitamin K Epoxide Reductases; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D012378:Rodenticides; D014874:Water Pollutants, Chemical; D006899:Mixed Function Oxygenases; D064417:Vitamin K Epoxide Reductases; C021636:bromadiolone