title: Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons.
abstract: The aim of this study was to investigate the actions of silver nanoparticles (nano-Ag) on glutamatergic synaptic transmission and excitability in hippocampal CA1 pyramidal neurons with whole cell patch technique. The amplitude of miniature excitatory postsynaptic currents (mEPSCs) was inhibited by silver nano-particles (nano-Ag) (10⁻⁵ g/ml and 10⁻⁴ g/ml), but the amplitude and frequency of spontaneous excitatory postsynaptic currents (sEPSCs) were increased by nano-Ag treatment (10⁻⁵ g/ml and 10⁻⁴ g/ml). Furthermore, nano-Ag (10⁻⁵ g/ml and 10⁻⁴ g/ml) increased the spontaneous network activity. These results provide further insights into the underlying mechanisms responsible for the effects of nano-Ag on central nervous system (CNS).
authors.affiliation: College of Medicine, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, P. R. China.
authors.forename: Zhaowei
authors.initials: Z
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Guogang
authors.initials: G
authors.lastname: Ren
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects*; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D017966:Pyramidal Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012834:Silver / Q000737:chemistry / Q000633:toxicity*
chemical_list: D012834:Silver