title: Complete regression of retinoblastoma following intra-arterial chemotherapy.
abstract: A 22-month-old girl with Group C unilateral retinoblastoma demonstrated dramatic tumor regression after two infusions of 5 mg of intra-arterial melphalan as primary therapy. Complete tumor control without recurrence was noted at 1 year. Retinal and choroidal perfusion was intact and the electroretinogram improved following therapy.
authors.affiliation: Ocular Oncology Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA.
authors.forename: Nina
authors.initials: N
authors.lastname: Ni
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.forename: Carlos G
authors.initials: CG
authors.lastname: Bianciotto
authors.forename: Pascal M
authors.initials: PM
authors.lastname: Jabbour
authors.forename: Robert H
authors.initials: RH
authors.lastname: Rosenwasser
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use*; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007223:Infant; D007261:Infusions, Intra-Arterial; D008558:Melphalan / Q000008:administration & dosage / Q000627:therapeutic use*; D009880:Ophthalmic Artery; D012160:Retina / Q000503:physiopathology; D019572:Retinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D012175:Retinoblastoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014463:Ultrasonography
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan