title: Resveratrol dietary supplementation shortens the free-running circadian period and decreases body temperature in a prosimian primate.
abstract: Resveratrol (RSV) is a dietary polyphenolic compound with several positive effects on metabolic functions and longevity. We tested the effect of RSV on the circadian clock in a nonhuman primate, the gray mouse lemur. The impact of a 2-week dietary supplementation of RSV on the rhythms of locomotor activity and body temperature in constant dark conditions (DD) was investigated in young (n = 7) and old (n = 6) animals. RSV supplementation followed 2 weeks in DD under normal diet (CTL). In both young and old animals receiving RSV, we observed a shortening of the free-running period compared to those under CTL (-15 minutes in young animals and -45 minutes in old animals), accompanied by a lower mean body temperature in both age groups and decreased locomotor activity in young animals. Thus, RSV is a food component capable of influencing a primate's circadian clock. This property may be of interest clinically in the context of the treatment of circadian disruption and in the context of the effects of RSV ingestion on health.
authors.forename: Fabien
authors.initials: F
authors.lastname: Pifferi
authors.forename: Alexandre
authors.initials: A
authors.lastname: Dal-Pan
authors.forename: Michael
authors.initials: M
authors.lastname: Menaker
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D016565:Cheirogaleidae / Q000502:physiology*; D002940:Circadian Rhythm / Q000187:drug effects*; D019587:Dietary Supplements; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol