title: Watershed infarcts in a multiple microembolic model of monkey.
abstract: It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50 μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Takakuni
authors.initials: T
authors.lastname: Maki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Wakita
authors.forename: Mitsuhito
authors.initials: M
authors.lastname: Mase
authors.forename: Iori
authors.initials: I
authors.lastname: Itagaki
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Saito
authors.forename: Fumiko
authors.initials: F
authors.lastname: Ono
authors.forename: Kayo
authors.initials: K
authors.lastname: Adachi
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Ito
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Takahashi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ihara
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tomimoto
mesh_terms: D000208:Acute Disease; D000818:Animals; D002544:Cerebral Infarction / Q000473:pathology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D020766:Intracranial Embolism / Q000473:pathology*; D008252:Macaca fascicularis; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008833:Microcirculation