title: [Determination of airborne and surface contamination with cyclophosphamide at the Masaryk Memorial Cancer Institute, Brno, Czech Republic].
abstract: Manipulation with cytotoxic drugs (CDs) during the preparation and administration of chemotherapy to cancer patients can potentially lead to contamination of working areas and consequently to occupational exposure of hospital staff. This study aimed to assess the potential of inhalation and dermal contact with CDs. For this purpose, distribution of the marker drug (cyclophosphamide, CP) in the working environment of the Masaryk Memorial Cancer Institute (Czech Republic) was studied. The study determined airborne and surface contamination of the hospital pharmacy and the outpatient clinic. Determination of airborne contamination was based on active stationary sampling of air using a PTFE filter, an impinger filled with distilled water and two solid sorbent tubes (Anasorb 708 and Strata-X) as sampling devices. Surface contamination was determined by the wipe sampling method. The airborne contamination was rare and the concentrations were many times lower than the maximal value calculated from the vapour pressure (0.36 mg/m3 at 20 degrees C). Detectable airborne CP was found in Strata-X samples collected at the outpatient clinic (n = 5, all samples positive at concentrations from 0.3 to 4.3 ng/m3). Surface contamination was determined at 75% of wipe samples (n = 65) with a median concentration of 750 ng/m2. In conclusion, inhalation of CDs seems to be of low importance at our hospital, which is up to the standard specified by current legislation (drug preparation performed in a clean room equipped with negative pressure isolators). The main proportion of contamination was present on the surfaces at all workplaces studied. Consequently, attention should be given to the elimination of the sources of surface contamination and to the prevention of dermal contact with contaminated material.
authors.affiliation: Masarykův onkologický ustav, Brno.
authors.forename: Lucie
authors.initials: L
authors.lastname: Gorná
authors.forename: Pavel
authors.initials: P
authors.lastname: Odráska
authors.forename: Lenka
authors.initials: L
authors.lastname: Dolezalová
authors.forename: Pavel
authors.initials: P
authors.lastname: Piler
authors.forename: Michal
authors.initials: M
authors.lastname: Oravec
authors.forename: Ludek
authors.initials: L
authors.lastname: Bláha
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis*; D018906:Antineoplastic Agents, Alkylating / Q000032:analysis*; D002173:Cancer Care Facilities; D003520:Cyclophosphamide / Q000032:analysis*; D004866:Equipment Contamination; D006801:Humans; D016273:Occupational Exposure
chemical_list: D000395:Air Pollutants, Occupational; D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide