title: Determination of carvedilol by its quenching effect on the luminescence of terbium complex in dosage form.
abstract: A new, simple, sensitive luminescence methods for the determination of carvedilol have been developed and validated. Carvedilol was remarkably quenching the luminescence intensity of the Tb(III) ion in the new terbium complex with 1-butyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid-(4-methyl-pyridin-2-yl)-amide (R) in aqueous solutions containing urotropine buffer (pH 7.5) at lambda(ex) = 317 nm and lambda(em) = 545 nm. Under optimal conditions, the quenching of luminescence intensity was found to be proportional to the concentration of carvedilol in the range of 0.5-400 microg/mL. The detection limit was 0.16 microg/mL. This method was applied for the determination of carvedilol in tablets "Coryol".
authors.affiliation: A.V. Bogatsky Physico-chemical Institute of the National Academy of Sciences of Ukraine, 86 Lustdorfskaya doroga, Odessa 65080, Ukraine.
authors.forename: Inna
authors.initials: I
authors.lastname: Leonenko
authors.forename: Darya
authors.initials: D
authors.lastname: Aleksandrova
authors.forename: Alla
authors.initials: A
authors.lastname: Yegorova
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000032:analysis*; D002021:Buffers; D002138:Calibration; D002227:Carbazoles / Q000032:analysis*; D000077261:Carvedilol; D006863:Hydrogen-Ion Concentration; D011412:Propanolamines / Q000032:analysis*; D015203:Reproducibility of Results; D013050:Spectrometry, Fluorescence / Q000592:standards; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000592:standards; D013725:Terbium / Q000737:chemistry*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D002021:Buffers; D002227:Carbazoles; D011412:Propanolamines; D013607:Tablets; D013725:Terbium; D000077261:Carvedilol