title: Liquid chromatography-mass spectrometry-based quantitative proteomics.
abstract: LC-MS-based quantitative proteomics has become increasingly applied to a wide range of biological applications due to growing capabilities for broad proteome coverage and good accuracy and precision in quantification. Herein, we review the current LC-MS-based quantification methods with respect to their advantages and limitations and highlight their potential applications.
authors.affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Qian
authors.forename: Vladislav A
authors.initials: VA
authors.lastname: Petyuk
authors.forename: Richard D
authors.initials: RD
authors.lastname: Smith
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods*; D006801:Humans; D007553:Isotope Labeling; D013058:Mass Spectrometry / Q000379:methods*; D040901:Proteomics / Q000379:methods* / Q000592:standards; D012015:Reference Standards