title: Analysis of counterfeit pharmaceutical tablet cores utilizing macroscopic infrared spectroscopy and infrared spectroscopic imaging.
abstract: Advantages and limitations of analyzing authentic and counterfeit pharmaceutical tablets with both macro (nonimaging) attenuated total internal reflection Fourier transform infrared (ATR-FT-IR) spectroscopy and micro ATR-FT-IR spectroscopic imaging have been evaluated. The results of this study demonstrated that micro ATR imaging was more effective for extracting formulation information (sourcing), whereas a macro ATR approach was better suited for counterfeit detection (screening). More importantly, this study demonstrated that a thorough analysis of the counterfeit core can be achieved by combining the results of both techniques.
authors.affiliation: Trace Examination Section, FDA Forensic Chemistry Center, Cincinnati, Ohio 45237, United States. adam.lanzarotta@fda.hhs.gov
authors.forename: Adam
authors.initials: A
authors.lastname: Lanzarotta
authors.forename: Kendra
authors.initials: K
authors.lastname: Lakes
authors.forename: Curtis A
authors.initials: CA
authors.lastname: Marcott
authors.forename: Mark R
authors.initials: MR
authors.lastname: Witkowski
authors.forename: Andre J
authors.initials: AJ
authors.lastname: Sommer
mesh_terms: D058110:Counterfeit Drugs / Q000032:analysis*; D008962:Models, Theoretical; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013607:Tablets / Q000737:chemistry*
chemical_list: D058110:Counterfeit Drugs; D013607:Tablets