title: Annexin C4 in A. fumigatus: a proteomics approach to understand the function.
abstract: Annexin C4 has been identified as a new member of fungal annexin family. In search of function, we have generated an annexin C4 disruptant strain of human pathogen, Aspergillus fumigatus. Detailed phenotypic analysis confirmed a non essential role of annexin C4 in the growth and sporulation of this pathogen. We applied a comparative proteomics strategy to understand the possible role of this protein in the fungus. The modification of respiratory chain proteins and stress response proteins suggests the occurrence of a mild oxidative stress in anxC4 disruptant strain. This may indicate a possible anti stress function of annexin C4 in A. fumigatus.
authors.affiliation: Fungal Biotechnology Group, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. khalajs@pasteur.ac.ir
authors.forename: Vahid
authors.initials: V
authors.lastname: Khalaj
authors.forename: Bahareh
authors.initials: B
authors.lastname: Azarian
authors.forename: Somayeh
authors.initials: S
authors.lastname: Enayati
authors.forename: Behrouz
authors.initials: B
authors.lastname: Vaziri
mesh_terms: D017302:Annexins / Q000235:genetics / Q000502:physiology*; D001232:Aspergillus fumigatus / Q000235:genetics / Q000378:metabolism*; D004579:Electron Transport / Q000235:genetics; D005656:Fungal Proteins / Q000502:physiology; D018384:Oxidative Stress
chemical_list: D017302:Annexins; D005656:Fungal Proteins