title: Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.
abstract: Inhibition of vascular smooth muscle cell (VSMC) proliferation is of substantial interest in combating cardiovascular disease. A dichloromethane extract from the rhizomes of Peucedanum ostruthium, a traditionally used Austrian medicinal plant with anti-inflammatory properties, was examined for a putative antiproliferative activity in rat aortic VSMC. This extract inhibited serum (10%)-induced VSMC proliferation concentration dependently. Further identification and biological testing of its major constituents revealed that the coumarin ostruthin (7) is the major antiproliferative substance. In summary, a new bioactivity of P. ostruthium rhizomes is described, and 7 has been identified as the responsible compound.
authors.affiliation: Department of Pharmacognosy, University of Vienna , Althanstrasse 14, 1090 Vienna, Austria.
authors.forename: Helge
authors.initials: H
authors.lastname: Joa
authors.forename: Sylvia
authors.initials: S
authors.lastname: Vogl
authors.forename: Atanas G
authors.initials: AG
authors.lastname: Atanasov
authors.forename: Martin
authors.initials: M
authors.lastname: Zehl
authors.forename: Thomas
authors.initials: T
authors.lastname: Nakel
authors.forename: Nanang
authors.initials: N
authors.lastname: Fakhrudin
authors.forename: Elke H
authors.initials: EH
authors.lastname: Heiss
authors.forename: Paolo
authors.initials: P
authors.lastname: Picker
authors.forename: Ernst
authors.initials: E
authors.lastname: Urban
authors.forename: Christoph
authors.initials: C
authors.lastname: Wawrosch
authors.forename: Johannes
authors.initials: J
authors.lastname: Saukel
authors.forename: Gottfried
authors.initials: G
authors.lastname: Reznicek
authors.forename: Brigitte
authors.initials: B
authors.lastname: Kopp
authors.forename: Verena M
authors.initials: VM
authors.lastname: Dirsch
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology / Q000187:drug effects*; D019661:Apiaceae / Q000737:chemistry*; D001317:Austria; D049109:Cell Proliferation / Q000187:drug effects*; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome / Q000737:chemistry; D014468:Umbelliferones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D014468:Umbelliferones; C008719:ostruthin