title: [Influence of MDR1 gene C3435T on peripheral white blood cell counts in workers exposed to benzene].
abstract: OBJECTIVE
  To explore the effects of MDR1 C3435T on the peripheral white blood cell counts in workers exposed to benzene.
  
  
  METHODS
  One hundred and twenty-one benzene-exposed workers and 110 healthy controls without benzene exposure were enrolled in this study. White blood cell counts influenced by the polymorphism of MDR1 gene were analyzed.
  
  
  RESULTS
  The frequency of MDR1 3435 C/C, C/T, T/T in healthy controls was 37.27%, 46.36%, 16.37%, respectively, and it was 38.84%, 41.33%, 19.83% in the benzene-exposed workers, respectively. The frequency of the MDR1 gene was also not significantly different between benzene exposed workers and controls. Subjects exposed to benzene with MDR1 3435 mutation genotype (T/T) had the significantly lower WBC [(5.46 ± 1.51) × 10(9)/L] than those carrying wild type (C/C) and heterozygous (C/T), whose WBC were (6.08 ± 1.28) × 10(9)/L (P = 0.044).
  
  
  CONCLUSIONS
  P-glycoprotein encoded by MDR1 gene may be implicated into the hematotoxicity of benzene. Subjects carrying MDR1 3435 T/T genotype may have a higher risk of benzene poisoning.
authors.affiliation: Department of Occupational Medicine, Fudan University, Shanghai 200540, China.
authors.forename: Jian-shu
authors.initials: JS
authors.lastname: Huang
authors.forename: Xin-jü
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Xu
authors.forename: Ming
authors.initials: M
authors.lastname: Guan
authors.forename: Yuan-ling
authors.initials: YL
authors.lastname: Zhou
authors.forename: Ling
authors.initials: L
authors.lastname: Lü
authors.forename: He-jian
authors.initials: HJ
authors.lastname: Zou
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000328:Adult; D001554:Benzene / Q000009:adverse effects*; D035061:Control Groups; D005260:Female; D005838:Genotype; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D020641:Polymorphism, Single Nucleotide
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001554:Benzene