title: One size fits all in prostate cancer: a story tale whose time has come and gone.
abstract: The touchstone to evaluate accurately the aggressiveness and invasiveness of prostate cancer is something of a holy grail in the facet of urologic oncology. Gene expression and sequencing studies have improved our interpretations of the genetic determinants of the disease but are unsuccessful in the establishment of any unified classification to improve the molecular stratification. These questions addressing failure in rational drug design are difficult to answer in the multifaceted and heterogeneous pathogenesis of prostate cancer. In this review, we have developed a roadmap of the "recalcitrant prostate cancer proteome" to recognize the aspects of prostate cancer that may be helpful in effectively translating these findings to the clinic.
authors.affiliation: Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Pakistan. Ammadahmad638@yahoo.com
authors.forename: Ammad Ahmad
authors.initials: AA
authors.lastname: Farooqi
authors.forename: Shahzad
authors.initials: S
authors.lastname: Bhatti
authors.forename: Ali
authors.initials: A
authors.lastname: Nawaz
authors.forename: Ahmad Mukhtar
authors.initials: AM
authors.lastname: Khalid
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D018450:Disease Progression; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D014411:Neoplastic Stem Cells / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D020543:Proteome / Q000235:genetics; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics; D011944:Receptors, Androgen / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D020543:Proteome; D011944:Receptors, Androgen; C496348:FGFR1 protein, human; D051496:Receptor, Fibroblast Growth Factor, Type 1