title: Gender-specific association between ACE gene I/D polymorphism and blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients.
abstract: To evaluate the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and gender with individual blood pressure response to hydrochlorothiazide (HCTZ) in hypertensives, we enrolled 829 mild-moderate hypertensive patients. All subjects were given HCTZ (12.5 mg) orally each day for 6 weeks. A total of 776 patients completed the study. There was statistically significant interaction between the effects of genotype and gender on systolic (P = 0.002) and diastolic (P = 0.048) response after adjusting for covariables. Moreover, in each gender, the genotype that was associated with the greatest blood pressure response to HCTZ (DD homozygotes in men and II homozygotes in women) was also associated with the greatest increase in serum ACE activity in response to HCTZ. The results suggest that the I/D polymorphism of the ACE gene is associated with interindividual differences in the blood pressure response to a low dose of a diuretic in a gender-specific manner in the Han Chinese population with hypertension.
authors.affiliation: School of Public Health, Hebei United University, Tangshan 063007, China. liyun8022@gmail.com
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
authors.forename: Juxiang
authors.initials: J
authors.lastname: Yuan
authors.forename: Chong
authors.initials: C
authors.lastname: Shen
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhao
authors.forename: Qi
authors.initials: Q
authors.lastname: Ren
authors.forename: Fumin
authors.initials: F
authors.lastname: Feng
authors.forename: Weijun
authors.initials: W
authors.lastname: Guan
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology*; D044466:Asian People; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors
chemical_list: D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A