title: Biomarkers in Serbian patients with Gaucher disease.
abstract: OBJECTIVE
  The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT).
  
  
  METHODS
  Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months.
  
  
  RESULTS
  The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 μg/L, and 555 μg/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%).
  
  
  CONCLUSIONS
  Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.
authors.affiliation: Center for Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia. zsumarac@open.telekom.rs
authors.forename: Zorica
authors.initials: Z
authors.lastname: Sumarac
authors.forename: Nada
authors.initials: N
authors.lastname: Suvajdžić
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ignjatović
authors.forename: Nada
authors.initials: N
authors.lastname: Majkić-Singh
authors.forename: Dragana
authors.initials: D
authors.lastname: Janić
authors.forename: Milan
authors.initials: M
authors.lastname: Petakov
authors.forename: Maja
authors.initials: M
authors.lastname: Dorđević
authors.forename: Mirjana
authors.initials: M
authors.lastname: Mitrović
authors.forename: Marijana
authors.initials: M
authors.lastname: Dajak
authors.forename: Milka
authors.initials: M
authors.lastname: Golubović
authors.forename: Predrag
authors.initials: P
authors.lastname: Rodić
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D056947:Enzyme Replacement Therapy; D005260:Female; D005293:Ferritins / Q000097:blood; D005776:Gaucher Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism*; D005962:Glucosylceramidase / Q000627:therapeutic use; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D055771:Serbia; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005293:Ferritins; D000135:Acid Phosphatase; D006596:Hexosaminidases; C086400:chitotriosidase; D005962:Glucosylceramidase; D007703:Peptidyl-Dipeptidase A; C090568:imiglucerase