title: [Mechanism of general anesthesia and antinociception].
abstract: Nitrous oxide exhibits antinociceptive effects by inhibition of transmission of nociceptive information from the primary afferent neuron to the spinal cord neuron through the activation of the descending inhibitory pathway. Furthermore, nitrous oxide might directly modulate the nociceptive transmission at the dorsal horn of the spinal cord. Analysis of knockout mice and pharmacological analysis suggest that the K -opioid receptor and the nociceptin receptor are involved in the antinociceptive effects of nitrous oxide. To elucidate the molecular mechanism in pharmacological effects of nitrous oxide, further investigation is necessary.
authors.affiliation: Department of Anesthesia, Kyoto University Hospital, Kyoto 606-8507.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Fukuda
mesh_terms: D000700:Analgesics; D000768:Anesthesia, General; D000818:Animals; D004298:Dopamine / Q000502:physiology; D006801:Humans; D009609:Nitrous Oxide / Q000494:pharmacology*; D018847:Opioid Peptides / Q000378:metabolism / Q000502:physiology; D011957:Receptors, Opioid / Q000502:physiology; D017473:Receptors, Opioid, kappa / Q000187:drug effects / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D000094942:Nociceptin Receptor; D000097629:Nociceptin
chemical_list: D000700:Analgesics; D004298:Dopamine; D009609:Nitrous Oxide; D018847:Opioid Peptides; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D000094942:Nociceptin Receptor; D000097629:Nociceptin; C000722283:OPRL1 protein, human