title: Soluble vascular adhesion protein-1: decreased activity in the plasma of trauma victims and predictive marker for severity of traumatic brain injury.
abstract: BACKGROUND
  This study done was to investigate the clinical significance of soluble vascular adhesion protein-1 (sVAP-1) activity in trauma patients with different patterns.
  
  
  METHODS
  96 patients with consecutive trauma ≥15 years who were admitted to emergency department of the Second Affiliated Hospital, Shantou University Medical College, China, between January 2007 and December 2009 were enrolled in this study. Plasma was collected at admission. Injury-severity score (ISS) and Glasgow Coma Scale (GCS) were used to determine the patient conditions. sVAP-1 activity was determined by using the high performance liquid chromatographic (HPLC) system.
  
  
  RESULTS
  Mean sVAP-1 activity in trauma patients was significantly lower than that of controls (P<0.0001), and the level was negatively correlated with circulating leucocytes and neutrophils (P<0.0001). There was a significant correlation between lower sVAP-1 activity and injury patterns. However, plasma sVAP-1 activity increased significantly in accordance with the severity of traumatic brain injury (TBI), and the patients with sVAP-1 value above 8.61 nmol/ml/h have much higher mortality rate (25.0%) than patients with sVAP-1 value lower than 8.61 nmol/ml/h (0.0%) (P=0.011).
  
  
  CONCLUSIONS
  Trauma patients had a decreased sVAP-1 activity. However, isolated TBI patients with higher activity of sVAP-1 at admission were more likely to have a poor outcome.
authors.affiliation: Bio-analytical Laboratory, Shantou University Medical College, Shantou, Guangdong Province, China.
authors.forename: Zhexuan
authors.initials: Z
authors.lastname: Lin
authors.forename: Ming
authors.initials: M
authors.lastname: Han
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Hongjun
authors.initials: H
authors.lastname: Luo
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wenhong
authors.initials: W
authors.lastname: Luo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D001930:Brain Injuries / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014947:Wounds and Injuries / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing)