title: [Single nucleotide polymorphisms of CTLA4 gene and their association with human cervical cancer].
abstract: OBJECTIVE
  To evaluate the association between single nucleotide polymorphisms (SNPs) of cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene and susceptibility to cervical cancer.
  
  
  METHODS
  One hundred patients and 100 healthy controls from Hubei province were genotyped for 20 polymorphic loci using Sequenom.
  
  
  RESULTS
  The frequency of rs11571316 G allele and rs5742909 T allele, which are localized in the promoter region, and rs11571319 A allele, which is downstream of the gene, were significantly higher in patients than in controls. Luciferase assay showed that, as the previously reported rs5742909 T allele, rs11571316 G allele could significantly increase the expression of the reporter gene.
  
  
  CONCLUSIONS
  SNPs in the promoter region of (CTLA4) gene might increase the susceptibility to cervical cancer by increasing (CTLA4) gene expression.
authors.affiliation: Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060 P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Ruo-yu
authors.initials: RY
authors.lastname: Luo
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Li-rong
authors.initials: LR
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Yan-xiang
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human