title: Apoptosis goes on a chip: advances in the microfluidic analysis of programmed cell death.
abstract: Recent years have brought enormous progress in cell-based lab-on-a-chip technologies, allowing dynamic studies of cell death with an unprecedented accuracy. As interest in the microfabricated technologies for cell-based bioassays is rapidly gaining momentum, we highlight the most promising technologies that provide a new outlook for the rapid assessment of programmed and accidental cell death and are applicable in drug discovery, high-content drug screening, and personalized clinical diagnostics.
authors.affiliation: The BioMEMS Research Group, Department of Chemistry, University of Auckland, Auckland, New Zealand. d.wlodkowic@auckland.ac.nz
authors.forename: Donald
authors.initials: D
authors.lastname: Wlodkowic
authors.forename: Khashayar
authors.initials: K
authors.lastname: Khoshmanesh
authors.forename: John C
authors.initials: JC
authors.lastname: Sharpe
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Darzynkiewicz
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Cooper
mesh_terms: D017209:Apoptosis; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D006801:Humans; D056656:Lab-On-A-Chip Devices; D046210:Microfluidic Analytical Techniques; D055616:Microtechnology; D008904:Miniaturization; D046888:Tissue Array Analysis