title: [Chronic myelogenous leukemia complicated by drug-induced agranulocytosis].
abstract: We describe a patient with chronic myelogenous leukemia (CML) who developed drug-induced agranulocytosis. A 75-year-old female was diagnosed with CML in December 2001. She had been receiving imatinib therapy for more than five years. In August 2007, she was hospitalized due to a severe neutropenia 10 days after colonoscopy. She was diagnosed as having agranulocytosis induced by colonoscopy premedication including scopolamine butylbromide and flumazenil. Severe neutropenia was resolved by G-CSF treatment without CML progression. Agranulocytosis in patients with CML is rare, but potentially lethal. Here, we report the clinical course in this patient.
authors.affiliation: Department of Hematology, Osaka City University Hospital, Osaka, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nakao
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshida
authors.forename: Takahiko
authors.initials: T
authors.lastname: Nakane
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Terada
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Nakamae
authors.forename: Ki-Ryang
authors.initials: KR
authors.lastname: Koh
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamane
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
mesh_terms: D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000209:etiology; D001549:Benzamides; D002086:Butylscopolammonium Bromide / Q000009:adverse effects*; D003113:Colonoscopy; D005260:Female; D005442:Flumazenil / Q000009:adverse effects*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology; D010879:Piperazines / Q000627:therapeutic use; D011292:Premedication / Q000009:adverse effects*; D011743:Pyrimidines / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D016179:Granulocyte Colony-Stimulating Factor; D002086:Butylscopolammonium Bromide; D005442:Flumazenil; D000068877:Imatinib Mesylate