title: Familial nontraumatic, nonaneurysmal subarachnoid hemorrhage: a report on three first-degree siblings.
abstract: Family history is a recognized risk factor in aneurysmal subarachnoid hemorrhage (SAH). The genetic and environmental contributions are actively researched. The authors of this report present a case series of 3 first-degree siblings affected by nontraumatic, angiographically negative SAH. Data in this study suggest that familial predisposition may also apply to spontaneous, nonaneurysmal SAH and that family history should be actively investigated in all such patients. The identification of families with multiple affected members could lead to an improved understanding of the genetic and environmental factors associated with this condition.
authors.affiliation: Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA. lazaridi@musc.edu
authors.forename: Christos
authors.initials: C
authors.lastname: Lazaridis
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Bodle
authors.forename: Imran
authors.initials: I
authors.lastname: Chaudry
authors.forename: Angela
authors.initials: A
authors.lastname: Hays
authors.forename: Julio
authors.initials: J
authors.lastname: Chalela
mesh_terms: D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D035781:Siblings; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging / Q000235:genetics*