title: Short-term infection of striped bass Morone saxatilis with Mycobacterium marinum.
abstract: Striped bass Morone saxatilis were studied in order to characterize their immune responses over the short term following challenge with Mycobacterium marinum. The expression of immunity-related genes (IL-1beta, TNF-alpha, Nramp and TGF-beta) quickly increased following infection with M. marinum, but these genes were subsequently down-regulated despite the fact that bacterial counts remained high. The number of monocytes and neutrophils also initially increased at 1 d postinfection. This confirms the importance of these types of cells in initial inflammation and mycobacterial infection in striped bass. The phagocytic index of splenic leukocytes over these same time frames did not change significantly following infection. The discrete window in which inflammatory mechanisms were stimulated in striped bass may be related to the intracellular nature of this pathogen.
authors.affiliation: School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, New York 11794-5000, USA.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Jeon
authors.forename: Lonnie C
authors.initials: LC
authors.lastname: Gonsalves
authors.forename: John M
authors.initials: JM
authors.lastname: Jacobs
authors.forename: Matt
authors.initials: M
authors.lastname: Rhodes
authors.forename: Jimmy
authors.initials: J
authors.lastname: Councilman
authors.forename: Ana
authors.initials: A
authors.lastname: Baya
authors.forename: Eric B
authors.initials: EB
authors.lastname: May
authors.forename: Mark D
authors.initials: MD
authors.lastname: Fast
mesh_terms: D000818:Animals; D001492:Bass; D005393:Fish Diseases / Q000382:microbiology*; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology / Q000662:veterinary*; D019910:Mycobacterium marinum; D013997:Time Factors