title: Energy evaluation of the compaction process of directly compressible isomalt.
abstract: The paper compares the compressibility of two directly compressible isomalts, galenIQ 720 and galenIQ721, using the energy evaluation of the compaction process by means of the force--displacement profiles. It evaluates the energies for friction, energies accumulated by the tablet, energy of decompression, energy of compaction and plasticity in pure dry binders, in dry binders with lubricants (0.5 and 1% of magnesium stearate and sodium stearyl fumarate) and further in the tableting materials containing the model ingredients acetylsalicylic acid and ascorbic acid. The results of the study have revealed that lower values of the energy for friction and compaction with the identical compression force are found by the substance galenIQ 720, which is therefore better compressible than the substance galenIQ 721.
authors.affiliation: Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Technology, Czech Republic. muzikova@faf.cuni.cz
authors.forename: Jitka
authors.initials: J
authors.lastname: Muzíková
authors.forename: Veronika
authors.initials: V
authors.lastname: Pavlasová
mesh_terms: D004187:Disaccharides; D055595:Mechanical Phenomena; D013402:Sugar Alcohols; D013607:Tablets; D013678:Technology, Pharmaceutical; D013718:Tensile Strength
chemical_list: D004187:Disaccharides; D013402:Sugar Alcohols; D013607:Tablets; C016640:Palatinit