title: Hemophagocytic lymphohistiocytosis after lung transplant: report of 2 cases and a literature review.
abstract: Hemophagocytic lymphohistiocytosis is a rare and often fatal disease that may occur in solid organ transplant recipients. Here, we describe 2 patients who developed hemophagocytic lymphohistiocytosis after having a lung transplant and present a review of all cases of hemophagocytic lymphohistiocytosis occurring in solid organ transplant recipients. Diagnosis of hemophagocytic lymphohistiocytosis relies on the association of clinical findings and the presence of hemophagocytosis. Clinical presentation is nonspecific and patients may present with unexplained sepsis or multiple organ failure. Management consists of treating the underlying process; but unfortunately, the prognosis is poor.
authors.affiliation: Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, USA. enriquedgz@uky.edu
authors.forename: Enrique
authors.initials: E
authors.lastname: Diaz-Guzman
authors.forename: Bei
authors.initials: B
authors.lastname: Dong
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Hobbs
authors.forename: Melissa V
authors.initials: MV
authors.lastname: Kesler
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
mesh_terms: D000328:Adult; D000368:Aged; D001856:Bone Marrow Examination; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D009102:Multiple Organ Failure / Q000209:etiology; D016896:Treatment Outcome