title: No association of toll-like receptor 2 polymorphisms with Alzheimer's disease in Han Chinese.
abstract: Toll-like receptor 2 (TLR2) represents a reasonable functional and positional candidate gene for Alzheimer's disease (AD) as it is located under the linkage region of AD on chromosome 4q, and is functionally involved in the microglia-mediated inflammatory response and amyloid β (Aβ) clearance. In the current study, 7 single nucleotide polymorphisms (SNPs) that span the TLR2 were selected and their associations with late-onset AD (LOAD) risk were assessed in a case-control sample comprising 785 individuals in a Han Chinese population. No significant differences in the frequency of TLR2 alleles, genotypes, and haplotypes in the AD cases were detected compared with the controls. TLR2 gene might not play a major role in the genetic predisposition to late-onset Alzheimer's disease in this population.
authors.affiliation: College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China. yu-jintai@163.com
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Sun
authors.forename: Jiang-Rong
authors.initials: JR
authors.lastname: Ou
authors.forename: Wei-Zhen
authors.initials: WZ
authors.lastname: Cui
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D051195:Toll-Like Receptor 2 / Q000235:genetics*
chemical_list: C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2