title: Acute myeloid leukemia (AML-M2) with translocation (8;21) (q22;q22) and abnormal eosinophilic precursors in the bone marrow--a case report.
abstract: The translocation (8;21)(q22;q22) is frequently associated with M2 subtype of AML. The authors herein present a case of AML-M2 in a nine-year-old boy without hepatosplenomegaly, lymphadenopathy or any bleeding diathesis. Bone marrow examination revealed high number of eosinophilic precursors (60%) among the total nucleated bone marrow cells. Cytogenetic study with G- banding method showed 46, XY, t (8;21)(q22;q22). The morphological abnormalities in eosinophils observed in AML suggested that eosinophils may be a part of leukemic process.
authors.affiliation: Department of Pathology, VMMC and Safdarjung Hospital, New Delhi, India. oneal80@gmail.com
authors.forename: Oneal
authors.initials: O
authors.lastname: Gupta
authors.forename: Roopak
authors.initials: R
authors.lastname: Aggarwal
authors.forename: Rajni
authors.initials: R
authors.lastname: Prasad
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002648:Child; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic