title: Identification of the first human gyrovirus, a virus related to chicken anemia virus.
abstract: We have identified in a skin swab sample from a healthy donor a new virus that we have named human gyrovirus (HGyV) because of its similarity to the chicken anemia virus (CAV), the only previously known member of the Gyrovirus genus. In particular, this virus encodes a homolog of the CAV apoptin, a protein that selectively induces apoptosis in cancer cells. By PCR screening, HGyV was found in 5 of 115 other nonlesional skin specimens but in 0 of 92 bronchoalveolar lavages or nasopharyngeal aspirates and in 0 of 92 fecal samples.
authors.affiliation: Institut Pasteur, Laboratory for Urgent Responses to Biological Threats, 25 rue du Docteur Roux, F-75015 Paris, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Sauvage
authors.forename: Justine
authors.initials: J
authors.lastname: Cheval
authors.forename: Vincent
authors.initials: V
authors.lastname: Foulongne
authors.forename: Meriadeg Ar
authors.initials: MA
authors.lastname: Gouilh
authors.forename: Kevin
authors.initials: K
authors.lastname: Pariente
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Manuguerra
authors.forename: Jennifer
authors.initials: J
authors.lastname: Richardson
authors.forename: Olivier
authors.initials: O
authors.lastname: Dereure
authors.forename: Marc
authors.initials: M
authors.lastname: Lecuit
authors.forename: Ana
authors.initials: A
authors.lastname: Burguiere
authors.forename: Valérie
authors.initials: V
authors.lastname: Caro
authors.forename: Marc
authors.initials: M
authors.lastname: Eloit
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D036022:Capsid Proteins / Q000737:chemistry; D017727:Chicken anemia virus / Q000145:classification*; D046810:Gyrovirus / Q000145:classification*; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D016133:Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid
chemical_list: D036022:Capsid Proteins; C091717:VP3 protein, Chicken anemia virus