title: Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS).
abstract: HSCT is being increasingly offered as a curative option for children with hematologic malignancies. Although survival has improved, the long-term morbidity ascribed to the HSCT procedure is not known. We compared the risk of chronic health conditions and adverse health among children with cancer treated with HSCT with survivors treated conventionally, as well as with sibling controls. HSCT survivors were drawn from BMTSS (N = 145), whereas conventionally treated survivors (N = 7207) and siblings (N = 4020) were drawn from CCSS. Self-reported chronic conditions were graded with CTCAEv3.0. Fifty-nine percent of HSCT survivors reported ≥ 2 conditions, and 25.5% reported severe/life-threatening conditions. HSCT survivors were more likely than sibling controls to have severe/life-threatening (relative risk [RR] = 8.1, P < .01) and 2 or more (RR = 5.7, P < .01) conditions, as well as functional impairment (RR = 7.7, P < .01) and activity limitation (RR = 6.3, P < .01). More importantly, compared with CCSS survivors, BMTSS survivors demonstrated significantly elevated risks (severe/life-threatening conditions: RR = 3.9, P < .01; multiple conditions: RR = 2.6, P < .01; functional impairment: RR = 3.5, P < .01; activity limitation: RR = 5.8, P < .01). Unrelated donor HSCT recipients were at greatest risk. Childhood HSCT survivors carry a significantly greater burden of morbidity not only compared with noncancer populations but also compared with conventionally treated cancer patients, providing evidence for close monitoring of this high-risk population.
authors.affiliation: Population Sciences, City of Hope, Duarte, CA 91010-3000, USA.
authors.forename: Saro H
authors.initials: SH
authors.lastname: Armenian
authors.forename: Can-Lan
authors.initials: CL
authors.lastname: Sun
authors.forename: Toana
authors.initials: T
authors.lastname: Kawashima
authors.forename: Mukta
authors.initials: M
authors.lastname: Arora
authors.forename: Wendy
authors.initials: W
authors.lastname: Leisenring
authors.forename: Charles A
authors.initials: CA
authors.lastname: Sklar
authors.forename: K Scott
authors.initials: KS
authors.lastname: Baker
authors.forename: Liton
authors.initials: L
authors.lastname: Francisco
authors.forename: Jennifer Berano
authors.initials: JB
authors.lastname: Teh
authors.forename: George
authors.initials: G
authors.lastname: Mills
authors.forename: F Lennie
authors.initials: FL
authors.lastname: Wong
authors.forename: Joseph
authors.initials: J
authors.lastname: Rosenthal
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Diller
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Oeffinger
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Forman
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Robison
authors.forename: Smita
authors.initials: S
authors.lastname: Bhatia
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000534:rehabilitation / Q000628:therapy*; D017741:Survivors / Q000706:statistics & numerical data; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult