title: Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease.
abstract: We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.
authors.affiliation: Department of Cardiology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhong
authors.forename: Yin
authors.initials: Y
authors.lastname: Quanzhong
authors.forename: Ma
authors.initials: M
authors.lastname: Genshan
authors.forename: Zhang
authors.initials: Z
authors.lastname: Hua
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ruolong
authors.forename: Wang
authors.initials: W
authors.lastname: Jiahong
authors.forename: Gao
authors.initials: G
authors.lastname: Chunheng