title: 1-Chloro-2-formyl indenes and tetralenes as antitubercular agents.
abstract: 1-Chloro-2-formyl indenes and tetralenes have been synthesized using Vilsmeier-Haack-Arnold reaction onto indanones and tetralones. Most of these analogues exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv strain with MICs ranging from 30 to 500 μg/mL. Analogue 13 was further modified to some derivatives. The most active analogue 23 showing MIC at 30 μg/mL was further evaluated for acute oral toxicity in Swiss albino mice and was found to be safe up to 300 mg/kg dose.
authors.affiliation: Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), PO CIMAP, Kukrail, Picnic Spot Road, Lucknow 226015, UP, India.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Chanda
authors.forename: Dharmendra
authors.initials: D
authors.lastname: Saikia
authors.forename: J K
authors.initials: JK
authors.lastname: Kumar
authors.forename: Jay Prakash
authors.initials: JP
authors.lastname: Thakur
authors.forename: Jyoti
authors.initials: J
authors.lastname: Agarwal
authors.forename: C S
authors.initials: CS
authors.lastname: Chanotiya
authors.forename: Karuna
authors.initials: K
authors.lastname: Shanker
authors.forename: Arvind S
authors.initials: AS
authors.lastname: Negi
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D007192:Indenes