title: Targeting tuberculosis through a small focused library of 1,2,3-triazoles.
abstract: Looking for new active molecules against Mycobacterium tuberculosis, a small focused library of 1,2,3-triazoles was efficiently prepared by click chemistry. Compounds were subsequently tested against different pathogenic and opportunistic mycobacteria including M. avium and M. tuberculosis. Two of them showed MIC at lower μg/mL concentration for M. avium and even below that for M. tuberculosis, being more potent that control drugs.
authors.affiliation: Instituto de Química Rosario (IQUIR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina. labadie@iquir-conicet.gov.ar
authors.forename: Guillermo R
authors.initials: GR
authors.lastname: Labadie
authors.forename: Agustina
authors.initials: A
authors.lastname: de la Iglesia
authors.forename: Héctor R
authors.initials: HR
authors.lastname: Morbidoni
mesh_terms: D057930:Click Chemistry; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D054852:Small Molecule Libraries; D014230:Triazoles