title: Long-term training induces a healthy inflammatory and endocrine emergent biomarker profile in elderly men.
abstract: The objective of the present study was to investigate the changes in a large panel of emergent geriatric biomarkers in long-term trained elderly men to analyze the effects of long-term exercise on an aged population. We collected blood samples from two groups of male volunteers older than 65 years who maintain a measure of functional independence: one group of sedentary subjects without a history of regular physical activity and the other of subjects who have sustained training, starting during adulthood (mean training time = 49 ± 8 years). We studied morbidity, polypharmacy, cellular and serological inflammatory parameters, and endocrine mediators. After adjusting for confounding factors, we observed reduced medication intake per subject and lower number of diseases per subject with statistical differences nearly significant in the long-term exercise group. We showed that long-term training was associated with lower levels of white blood cell counts, neutrophil counts, interleukin-6, interleukin-10, interleukin-1 receptor antagonist, and soluble TNF receptor-I. Furthermore, we noted an increase in the concentrations of insulin-like growth factor-1 and dehydroepiandrosterone in the long-term training group. We concluded that long-term exercise training from adulthood to old age is clearly associated with a healthy profile of emergent geriatric biomarkers. Long-term training could improve the inflammatory-endocrine imbalance associated with disease, frailty, functional decline, and mortality in elderly men. Our results point to the benefits of prolonged exercise from adulthood to old age.
authors.affiliation: Department of Morphology and Cellular Biology, Faculty of Medicine, University of Oviedo, Spain. ddgonzalo@hotmail.com
authors.forename: David
authors.initials: D
authors.lastname: de Gonzalo-Calvo
authors.forename: Benjamín
authors.initials: B
authors.lastname: Fernández-García
authors.forename: Beatriz
authors.initials: B
authors.lastname: de Luxán-Delgado
authors.forename: Susana
authors.initials: S
authors.lastname: Rodríguez-González
authors.forename: Marina
authors.initials: M
authors.lastname: García-Macia
authors.forename: Francisco Manuel
authors.initials: FM
authors.lastname: Suárez
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Solano
authors.forename: María Josefa
authors.initials: MJ
authors.lastname: Rodríguez-Colunga
authors.forename: Ana
authors.initials: A
authors.lastname: Coto-Montes
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005500:Follow-Up Studies; D006728:Hormones / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D011379:Prognosis; D012016:Reference Values; D013997:Time Factors
chemical_list: D015415:Biomarkers; D016207:Cytokines; D006728:Hormones