title: Pregravid cardiometabolic risk profile and risk for gestational diabetes mellitus.
abstract: OBJECTIVE
  The purpose of this study was to examine pregravid cardiometabolic profile and subsequent risk of gestational diabetes mellitus (GDM).
  
  
  METHODS
  GDM cases (n = 199) and control subjects (n = 381) were selected from a cohort of women who took part in a multiphasic health checkup examination at Kaiser Permanente from 1984-1996 and who had a subsequent pregnancy and were matched by year and age at multiphasic health checkup examination and age at delivery.
  
  
  RESULTS
  Pregravid measurements of serum glucose levels of 100-140 mg/dL, body mass index of ≥ 25.0 kg/m(2), and prehypertension/hypertension level were associated independently with GDM risk (odds ratios [OR], 4.8; 95% confidence interval [CI], 1.7-13.9; OR, 2.7; 95% CI, 1.6-4.3; and OR, 1.5; 95% CI, 1.0-2.3, respectively). The risk of GDM increased with the number of cardiometabolic risk factors (P < .001); adverse levels of both body mass index and glucose were associated with a 4.6-fold increased risk of GDM, compared with women with normal levels (P = .0001).
  
  
  CONCLUSIONS
  Pregravid cardiometabolic risk profile may help clinicians to identify high-risk women to target for primary prevention or early management of GDM.
authors.affiliation: Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612-2304, USA. Monique.m.hedderson@kp.org
authors.forename: Monique M
authors.initials: MM
authors.lastname: Hedderson
authors.forename: Jeanne A
authors.initials: JA
authors.lastname: Darbinian
authors.forename: Charles P
authors.initials: CP
authors.lastname: Quesenberry
authors.forename: Assiamira
authors.initials: A
authors.lastname: Ferrara
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology / Q000209:etiology; D012306:Risk
chemical_list: D001786:Blood Glucose