title: Association of major histocompatibility complex class I chain-related gene A microsatellite polymorphism and hepatocellular carcinoma in South China Han population.
abstract: The major histocompatibility complex (MHC) class I-related gene A (MICA) is a stress-induced antigen and plays a key role in anti-infectious and anti-tumoral immune responses. In this study, we investigated the MICA transmembrane polymorphism in hepatocellular carcinoma (HCC) patients in South China Han population. We found that the MICA-A5.1 polymorphism, which gives rise to a truncated protein, was increased in HCC patients compared with healthy controls (P(c) = 0.036). Furthermore, we found that HCC patients with MICA-A5.1 polymorphism had higher serum levels of soluble MICA (sMICA). These results suggest that MICA-A5.1 polymorphism is associated with HCC patients in South China Han population and the MICA-A5.1 polymorphism may contribute to the development of HCC by promoting the release of sMICA to evade tumor immunosurveillance.
authors.affiliation: Department of Immunology, Xiang Ya School of Medicine, Central South University, Changsha, China.
authors.forename: X
authors.initials: X
authors.lastname: Jiang
authors.forename: Y
authors.initials: Y
authors.lastname: Zou
authors.forename: Z
authors.initials: Z
authors.lastname: Huo
authors.forename: P
authors.initials: P
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000235:genetics*; D002681:China; D005006:Ethnicity; D005260:Female; D005805:Genes, MHC Class I; D020022:Genetic Predisposition to Disease; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000208:ethnology / Q000235:genetics*; D008207:Lymphatic Metastasis; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A