title: Methyl-Analyzer--whole genome DNA methylation profiling.
abstract: CONCLUSIONS
  Methyl-Analyzer is a python package that analyzes genome-wide DNA methylation data produced by the Methyl-MAPS (methylation mapping analysis by paired-end sequencing) method. Methyl-MAPS is an enzymatic-based method that uses both methylation-sensitive and -dependent enzymes covering >80% of CpG dinucleotides within mammalian genomes. It combines enzymatic-based approaches with high-throughput next-generation sequencing technology to provide whole genome DNA methylation profiles. Methyl-Analyzer processes and integrates sequencing reads from methylated and unmethylated compartments and estimates CpG methylation probabilities at single base resolution.
  
  
  METHODS
  Methyl-Analyzer is available at http://github.com/epigenomics/methylmaps. Sample dataset is available for download at http://epigenomicspub.columbia.edu/methylanalyzer_data.html.
  
  
  BACKGROUND
  fgh3@columbia.edu
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Xin
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Ge
authors.forename: Fatemeh G
authors.initials: FG
authors.lastname: Haghighi
mesh_terms: D018899:CpG Islands; D019175:DNA Methylation; D015254:DNA Modification Methylases; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing; D017422:Sequence Analysis, DNA; D012984:Software
chemical_list: D015254:DNA Modification Methylases