title: Effect of high pressure on the organocatalytic asymmetric Michael reaction: highly enantioselective synthesis of γ-nitroketones with quaternary stereogenic centers.
abstract: The significant effect of hydrostatic pressure on the difficult organocatalytic 1,4-conjugate addition of nitroalkanes to prochiral sterically congested β,β-disubstituted enones is demonstrated. This approach allows for the synthesis of γ-nitroketones containing quaternary stereogenic centers with good yields, excellent enantioselectivity, and low loading (1-5 mol %) of simple chiral primary amine catalysts.
authors.affiliation: Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland. pkwiat@chem.uw.edu.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Kwiatkowski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Dudziński
authors.forename: Dawid
authors.initials: D
authors.lastname: Łyżwa