title: Serum C-reactive protein level as a biomarker for differentiation of ischemic from hemorrhagic stroke.
abstract: Cerebrovascular accidents rank first in the frequency and importance among all neurological disease. Although a number of studies had shown increased level of the high sensitive C-reactive protein (hs-CRP) in patients with ischemic stroke, the association of increased hs-CRP with various type of stroke especially the assessment hs-CRP level in ischemic and hemorrhagic stroke have not been investigated. In the present study, we assessed the concentration of hs-CRP in patients with documented ischemic and hemorrhagic stroke in the first 24 hours of the onset of symptoms. Thirty-two patients with Ischemic and hemorrhagic stroke were evaluated at neurology department of Poursina Hospital. The presence of baseline vascular risk factors, including hypertension, diabetes mellitus, hypercholesterolemia, obesity, and smoking, was determined. The blood samples were then collected and routine hematology and biochemistry tests were done. hs-CRP levels were determined using a highly sensitive immunonephelometric method. In this cross sectional study, the age of patient varied from 45-85 years (Mean 70.9 ± 9.4). Serum level of hs-CRP in Ischemic patients were 18.92 ± 11.28 and in hemorrhagic group was 2.65 ± 1.7. This relationship was statistically significant (P<0.0001). It might be concluded that hs-CRP might be considered as a usefully adjunct method for the initial diagnosis of the type of stroke.
authors.affiliation: Department of Immonology and Microbiology, Poursina Hospital, School of Medicine Guilan University of Medical Sciences, Guilan, Iran.
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Roudbary
authors.forename: Farshid
authors.initials: F
authors.lastname: Saadat
authors.forename: Kambiz
authors.initials: K
authors.lastname: Forghanparast
authors.forename: Reza
authors.initials: R
authors.lastname: Sohrabnejad
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D002097:C-Reactive Protein / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000209:etiology*
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein