title: Association between a thyroid hormone receptor-α gene polymorphism and blood pressure but not with coronary heart disease risk.
abstract: BACKGROUND
  Thyroid hormones (THs) exert multiple biological roles including effects on the cardiovascular system (lipid profile, blood pressure (BP) and cardiac output). The lipid-lowering actions of TH are mediated by the TH receptor-β whereas the mechanisms explaining the BP variations concomitant with the thyroid disorders are less understood. As the TH receptor-α (TR-α) has been associated with many of TH actions on the cardiovascular system in mice models, we hypothesized that it could be involved in the latter. We thus tested whether polymorphisms in TR-α (THRA gene) could be associated with BP level variation. Secondarily, we tested for association with coronary heart disease (CHD) risk.
  
  
  METHODS
  We analyzed the associations between five THRA polymorphisms and (i) BP level in two population-based studies (MONICA Lille n = 1,155; MONICA Toulouse n = 1,170) and (ii) the risk of CHD in two case-control studies (Lille CHD n = 558 cases/568 controls; PRIME n = 527 cases/584 controls).
  
  
  RESULTS
  Individuals carrying the rs939348 T allele had higher systolic BP (~+1.3 mm Hg) than CC individuals in both the MONICA Lille (P = 0.02) and Toulouse (P = 0.03) studies. The odds ratio (OR) for hypertension was 1.25 (P = 0.02) in the combined sample. Concerning the CHD risk, no significant association could be detected.
  
  
  CONCLUSIONS
  For the first time, our study showed associations between the THRA rs939348 polymorphism and systolic BP and the risk of hypertension but not with CHD, although we admit that the statistical power available to study any relationship with CHD was very limited. Further larger association studies are needed to confirm our findings.
authors.affiliation: INSERM, U744, Institut Pasteur de Lille, Univ Lille Nord de France, Lille, France.
authors.forename: Louisa
authors.initials: L
authors.lastname: Goumidi
authors.forename: Karine
authors.initials: K
authors.lastname: Gauthier
authors.forename: Vanessa
authors.initials: V
authors.lastname: Legry
authors.forename: Thérèse Hèrvée
authors.initials: TH
authors.lastname: Mayi
authors.forename: Alexia
authors.initials: A
authors.lastname: Houzet
authors.forename: Dominique
authors.initials: D
authors.lastname: Cottel
authors.forename: Michèle
authors.initials: M
authors.lastname: Montaye
authors.forename: Carole
authors.initials: C
authors.lastname: Proust
authors.forename: Frank
authors.initials: F
authors.lastname: Kee
authors.forename: Jean
authors.initials: J
authors.lastname: Ferrières
authors.forename: Dominique
authors.initials: D
authors.lastname: Arveiler
authors.forename: Pierre
authors.initials: P
authors.lastname: Ducimetière
authors.forename: Bart
authors.initials: B
authors.lastname: Staels
authors.forename: Jean
authors.initials: J
authors.lastname: Dallongeville
authors.forename: Giulia
authors.initials: G
authors.lastname: Chinetti
authors.forename: Frédéric
authors.initials: F
authors.lastname: Flamant
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Aline
authors.initials: A
authors.lastname: Meirhaeghe
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000235:genetics*; D003327:Coronary Disease / Q000209:etiology* / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D037021:Thyroid Hormone Receptors alpha / Q000235:genetics*
chemical_list: D037021:Thyroid Hormone Receptors alpha