title: Lack of association between genetic variations in the KALRN region and ischemic stroke.
abstract: OBJECTIVE
  To investigate whether KALRN gene variation is associated with ischemic stroke (IS).
  
  
  METHODS
  Associations to overall IS and IS subtypes were investigated in SAHLSIS, which comprises 844 patients with IS and 668 controls.
  
  
  RESULTS
  Associations between KALRN SNPs and overall IS and cardioembolic stroke were detected. Associations for overall IS were investigated in two additional Swedish samples, but could not be replicated.
  
  
  CONCLUSIONS
  KALRN gene variation is not associated with overall IS.
authors.affiliation: Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden. sandra.olsson@neuro.gu.se
authors.forename: Sandra
authors.initials: S
authors.lastname: Olsson
authors.forename: Katarina
authors.initials: K
authors.lastname: Jood
authors.forename: Olle
authors.initials: O
authors.lastname: Melander
authors.forename: Marketa
authors.initials: M
authors.lastname: Sjögren
authors.forename: Bo
authors.initials: B
authors.lastname: Norrving
authors.forename: Michael
authors.initials: M
authors.lastname: Nilsson
authors.forename: Arne
authors.initials: A
authors.lastname: Lindgren
authors.forename: Christina
authors.initials: C
authors.lastname: Jern
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*; D013548:Sweden
chemical_list: D020662:Guanine Nucleotide Exchange Factors; C503866:KALRN protein, human; D017346:Protein Serine-Threonine Kinases