title: Acridanone alkaloid in Baliospermum montanum--evaluation of its effect against anaphylaxis.
abstract: Baliospermum montanum leaves yielded 3-hydroxy-2,4-dimethoxy-10-methyl-9-acridanone (1), an alkaloid from the CHCl₃ fraction. Spectroscopic analysis was performed to assign the structure of the new compound (1) and its absolute configuration. The compound was evaluated for its effect in anaphylaxis by estimation of the release of histamine in systemic anaphylaxis model. The acridanone alkaloid significantly inhibited the degranulation of mast cells up to 65.22 % and 75.12 % at a dose of 50 and 75 mg/kg, respectively.
authors.affiliation: School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
authors.forename: Pichairajan
authors.initials: P
authors.lastname: Venkatesh
authors.forename: Pulok K
authors.initials: PK
authors.lastname: Mukherjee
authors.forename: Bikas C
authors.initials: BC
authors.lastname: Pal
mesh_terms: D054831:Acridones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D019665:Euphorbiaceae / Q000737:chemistry*; D006633:Histamine Antagonists / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008407:Mast Cells / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: C579825:3-hydroxy-2,4-dimethoxy-10-methyl-9-acridanone; D054831:Acridones; D000470:Alkaloids; D006633:Histamine Antagonists; D010936:Plant Extracts