title: Cell polarity and migration: emerging role for the endosomal sorting machinery.
abstract: The endosomal sorting complex required for transport (ESCRT) machinery has been implicated in the regulation of endosomal sorting, cell division, viral budding, autophagy, and cell signaling. Here, we review recent evidence that implicates ESCRTs in cell polarity and cell migration, and discuss the potential role of ESCRTs as tumor suppressors.
authors.affiliation: Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Norway.
authors.forename: Viola Hélène
authors.initials: VH
authors.lastname: Lobert
authors.forename: Harald
authors.initials: H
authors.lastname: Stenmark
mesh_terms: D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D025521:Tumor Suppressor Proteins