title: Sustained motion perception deficit following optic neuritis: Behavioral and cortical evidence.
abstract: OBJECTIVE
  To assess the recovery process in patients after an acute optic neuritis (ON) attack, comparing static and dynamic visual functions.
  
  
  METHODS
  In this prospective controlled study, 21 patients with unilateral, first-ever ON were followed over the course of 1 year. Standard visual tests, visual evoked potentials, and optical coherence tomography were assessed repeatedly. In addition, we developed a novel set of motion perceptual tasks to test dynamic visual deficits. fMRI examinations were performed to study the neuronal correlates for the behavioral findings.
  
  
  RESULTS
  Four months after the acute phase, the affected eyes had returned to normal performance levels in the routine visual testing. However, motion perception remained impaired throughout the 12-month period. In agreement with the clinical findings, fMRI studies showed recovery in cortical activation during static object recognition, as opposed to sustained deficit in tasks that require motion perception.
  
  
  CONCLUSIONS
  Sustained motion perception deficit following ON may explain the continued visual complaints of patients long after recovery of visual acuity. Cortical activation patterns suggest that if plastic processes in higher visual regions contribute to the recovery of vision, this may be limited to static visual functions. Alternatively, cortical activation may reflect the visual percept (intact for visual acuity and impaired for motion perception), rather than demonstrating plastic processes. We suggest that motion perception should be included in the routine ophthalmologic tests following ON.
authors.affiliation: Department of Neurology, Hadassah Hebrew-University Hospital, Jerusalem, Israel.
authors.forename: N
authors.initials: N
authors.lastname: Raz
authors.forename: S
authors.initials: S
authors.lastname: Dotan
authors.forename: T
authors.initials: T
authors.lastname: Benoliel
authors.forename: S
authors.initials: S
authors.lastname: Chokron
authors.forename: T
authors.initials: T
authors.lastname: Ben-Hur
authors.forename: N
authors.initials: N
authors.lastname: Levin
mesh_terms: D000293:Adolescent; D000328:Adult; D001519:Behavior / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009039:Motion Perception / Q000502:physiology*; D009902:Optic Neuritis / Q000150:complications* / Q000503:physiopathology*; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000209:etiology* / Q000503:physiopathology*; D014787:Vision Tests; D055815:Young Adult