title: Clinical symptoms of skin, nails, and joints manifest independently in patients with concomitant psoriasis and psoriatic arthritis.
abstract: This study correlated assessment tools for evaluating the severity of skin, nail, and joint symptoms in patients with psoriasis (Pso) and psoriatic arthritis (PsA). Adults with plaque Pso (with or without PsA) were enrolled from four U.S. institutions. Patients were evaluated using a novel 10-area Linear Psoriasis Area and Severity Index (XL-PASI), Psoriatic Arthritis Assessment (PsAA), Psoriatic Arthritis Screening and Evaluation Questionnaire (PASE), Nail Assessment (NA) and Joint Assessment (JA) tools, Psoriasis Weighted Extent and Severity Index (PWESI), and Lattice Physician Global Assessment (LS-PGA). Correlations between assessment tools and individual items in the assessment tools were performed. Data from 180 patients (55 with PsA) were analyzed. Highest correlations between tools (r = 0.77-0.88) were between the XL-PASI, PWESI and LS-PGA. Individual items in the XL-PASI correlated with items in the PWESI for extent skin symptoms, but not for all body areas. Overall, correlations were seen between hands and feet, between face and scalp, and between buttocks, chest, and back. Only low correlation was seen between items assessing joint symptoms with items assessing skin symptoms. These data support the notion that the complex phenotype of psoriatic disease requires instruments that assess the severity of skin, nails, and joints separately.
authors.affiliation: The Rockefeller University, New York, New York, United States of America.
authors.forename: Knut M
authors.initials: KM
authors.lastname: Wittkowski
authors.forename: Craig
authors.initials: C
authors.lastname: Leonardi
authors.forename: Alice
authors.initials: A
authors.lastname: Gottlieb
authors.forename: Alan
authors.initials: A
authors.lastname: Menter
authors.forename: Gerald G
authors.initials: GG
authors.lastname: Krueger
authors.forename: Paul W
authors.initials: PW
authors.lastname: Tebbey
authors.forename: Jennifer
authors.initials: J
authors.lastname: Belasco
authors.forename: Razieh
authors.initials: R
authors.lastname: Soltani-Arabshahi
authors.forename: John
authors.initials: J
authors.lastname: Gray
authors.forename: Liz
authors.initials: L
authors.lastname: Horn
authors.forename: James G
authors.initials: JG
authors.lastname: Krueger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015535:Arthritis, Psoriatic / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D017322:Clinical Trials, Phase II as Topic; D018450:Disease Progression; D005260:Female; D006801:Humans; D007596:Joints; D008297:Male; D008875:Middle Aged; D009262:Nails; D012867:Skin; D055815:Young Adult