title: Development of antitrypanosomal and antiplasmodial nonpeptidic cysteine protease inhibitors based on N-protected-guanidino-furan and -pyrrole building blocks.
authors.affiliation: Institute of Organic Chemistry, University of Duisburg-Essen, Universitätstrasse 7, 45141 Essen, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Langolf
authors.forename: Uwe
authors.initials: U
authors.lastname: Machon
authors.forename: Martin
authors.initials: M
authors.lastname: Ehlers
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Sicking
authors.forename: Tanja
authors.initials: T
authors.lastname: Schirmeister
authors.forename: Christian
authors.initials: C
authors.lastname: Büchhold
authors.forename: Christoph
authors.initials: C
authors.lastname: Gelhaus
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenthal
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmuck
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry; D006146:Guanidines / Q000737:chemistry; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D011758:Pyrroles / Q000737:chemistry; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D014352:Trypanosomiasis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D000962:Antimalarials; D015853:Cysteine Proteinase Inhibitors; D005663:Furans; D006146:Guanidines; D011758:Pyrroles; D014344:Trypanocidal Agents; C039281:furan