title: Regulation of DREAM Expression by Group I mGluR.
abstract: DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.
authors.affiliation: Department of Pharmacology, Yonsei University College of Medicine, Seoul 120-752, Korea.
authors.forename: Jinu
authors.initials: J
authors.lastname: Lee
authors.forename: Insook
authors.initials: I
authors.lastname: Kim
authors.forename: So Ra
authors.initials: SR
authors.lastname: Oh
authors.forename: Suk Jin
authors.initials: SJ
authors.lastname: Ko
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Lim
authors.forename: Dong Goo
authors.initials: DG
authors.lastname: Kim
authors.forename: Chul Hoon
authors.initials: CH
authors.lastname: Kim