title: Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice.
abstract: Complementary DNA microarray analysis of human livers cannot exclude the influence of the immunological response. In this study, complementary DNA microarray analysis was performed under immunodeficient conditions with human hepatocyte chimeric mice, and gene expression profiles were analyzed by hepatitis B virus (HBV) infection and/or interferon treatment. The expression levels of 183 of 525 genes upregulated by interferon treatment were significantly suppressed in response to HBV infection. Suppressed genes were statistically significantly associated with the interferon signaling pathway and pattern recognition receptors in the bacteria/virus recognition pathway (P = 1.0 × 10(-8) and P = 1.2 × 10(-8), respectively). HBV infection attenuated virus recognition and interferon response in hepatocytes, which facilitated HBV escape from innate immunity.
authors.affiliation: Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Tsuge
authors.forename: Shoichi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Hiraga
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Zhang
authors.forename: Fukiko
authors.initials: F
authors.lastname: Mitsui
authors.forename: Hiromi
authors.initials: H
authors.lastname: Abe
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Kawaoka
authors.forename: Michio
authors.initials: M
authors.lastname: Imamura
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ochi
authors.forename: C Nelson
authors.initials: CN
authors.lastname: Hayes
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Chayama
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D006509:Hepatitis B / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D022781:Hepatocytes / Q000821:virology*; D006801:Humans; D057131:Immune Evasion; D007108:Immune Tolerance; D007372:Interferons / Q000276:immunology*; D051379:Mice; D016513:Mice, SCID; D046228:Microarray Analysis
chemical_list: D007372:Interferons