title: Relationship between transcranial Doppler variables in acute stage and outcome of intracerebral hemorrhage.
abstract: OBJECTIVE
  To investigate the characteristics of transcranial Doppler variables in the acute stage of intracerebral hemorrhage (ICH) and its relationship with 14-day death and outcomes at 90 day after onset.
  
  
  METHODS
  Ninety first-time supratentorial nontraumatic ICH patients were prospectively included. Computed tomography and transcranial Doppler examinations were performed on the first, third, seventh, and fourteenth day after onset. Transcranial Doppler variables were obtained from bilateral middle cerebral arteries. The relationship between ICH outcome and the following variables were analyzed: systolic (V(s)), diastolic (V(d)), mean (V(m)) velocities, and pulsatiliy index (PI) from affected and unaffected hemispheres.
  
  
  RESULTS
  Fourteen (15.6%) patients died within 14 days after onset of ICH. The stepwise logistic regression analyses proved presence of intraventricular hemorrhage (OR: 11.91; 95%CI: 1.62-87.42) and PI from unaffected hemisphere (OR: 1.64; 95%CI: 1.19-2.25) to be independent predictors of 14-day death. Forty-eight of the 90 ICH patients performed the transcranial Doppler monitoring at all four time points. V(m) from both hemispheres decreased gradually within 14 days after onset. Among the 48 patients, 22 patients were dependent (modified Rankin Scale ≥ 3) at 90 days after onset. Compared with patients who were independent at 90 days, V(d) (F = 4.98, P = 0.03) and V(m) (F = 7.30, P<0.01) from unaffected hemisphere were significantly lower, while the PI was significantly higher in patients who were dependent (F = 9.84, P<0.01).
  
  
  CONCLUSIONS
  Presence of intraventricular hemorrhage and PI from unaffected hemisphere proved to be independent predictors of 14-day death. Sustained persistent decreases in V(d) and V(m) and increases in PI from the unaffected hemisphere during the acute stage may be related with dependency at 90 days.
authors.affiliation: Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Wang
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Yang
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.forename: David
authors.initials: D
authors.lastname: Dornbos
authors.forename: Chunxue
authors.initials: C
authors.lastname: Wang
authors.forename: Xinjie
authors.initials: X
authors.lastname: Song
authors.forename: Xiping
authors.initials: X
authors.lastname: Gong
authors.forename: Anxin
authors.initials: A
authors.lastname: Wang
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging* / Q000401:mortality*; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*