title: Strength of default mode resting-state connectivity relates to white matter integrity in children.
abstract: A default mode network of brain regions is known to demonstrate coordinated activity during the resting state. While the default mode network is well characterized in adults, few investigations have focused upon its development. We scanned 9-13-year-old children with diffusion tensor imaging and resting-state functional magnetic resonance imaging. We identified resting-state networks using Independent Component Analysis and tested whether the functional connectivity between the medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC) depends upon the maturation of the underlying cingulum white matter tract. To determine the generalizability of this relationship, we also tested whether functional connectivity depends on white matter maturity between bilateral lateral prefrontal cortex (lateral PFC) within the executive control network. We found a positive relationship between mPFC-PCC connectivity and fractional anisotropy of the cingulum bundle; this positive relationship was moderated by the age of the subjects such that it was stronger in older children. By contrast, no such structure-function relationship emerged between right and left lateral PFC. However, functional and structural connectivity of this tract related positively with cognitive speed, fluency, and set-switching neuropsychological measures.
authors.affiliation: Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, USA.
authors.forename: Evan M
authors.initials: EM
authors.lastname: Gordon
authors.forename: Philip S
authors.initials: PS
authors.lastname: Lee
authors.forename: Jose M
authors.initials: JM
authors.lastname: Maisog
authors.forename: Jennifer
authors.initials: J
authors.lastname: Foss-Feig
authors.forename: Michael E
authors.initials: ME
authors.lastname: Billington
authors.forename: John
authors.initials: J
authors.lastname: Vanmeter
authors.forename: Chandan J
authors.initials: CJ
authors.lastname: Vaidya
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001921:Brain / Q000502:physiology; D001931:Brain Mapping / Q000379:methods*; D002648:Child; D003071:Cognition; D056324:Diffusion Tensor Imaging / Q000379:methods*; D056344:Executive Function; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*