title: Molecular organization of the basement membrane zone.
abstract: The dermal-epidermal basement membrane is a complex assembly of proteins that provide adhesion and regulate many important processes such as development, wound healing, and cancer progression. This contribution focuses on the structure and function of individual components of the basement membrane, how they assemble together, and how they participate in human tissues and diseases, with an emphasis on skin involvement. Understanding the composition and structure of the basement membrane provides insight into the pathophysiology of inherited blistering disorders, such as epidermolysis bullosa, and acquired bullous diseases, such as the pemphigoid group of autoimmune diseases and epidermolysis bullosa acquisita.
authors.affiliation: Stanford University School of Medicine, Li Ka Shing Building, 291 Campus Drive, Stanford, CA 94305, USA.
authors.forename: Sana
authors.initials: S
authors.lastname: Hashmi
authors.forename: M Peter
authors.initials: MP
authors.lastname: Marinkovich
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000737:chemistry; D001485:Basement Membrane / Q000737:chemistry* / Q000648:ultrastructure*; D002352:Carrier Proteins / Q000737:chemistry; D002471:Cell Transformation, Neoplastic / Q000737:chemistry; D024143:Collagen Type VII / Q000737:chemistry; D003598:Cytoskeletal Proteins / Q000737:chemistry; D000071821:Dystonin; D004817:Epidermis / Q000737:chemistry* / Q000648:ultrastructure*; D019812:Heparan Sulfate Proteoglycans / Q000737:chemistry; D006801:Humans; D016023:Integrins / Q000737:chemistry; D007797:Laminin / Q000737:chemistry; D008562:Membrane Glycoproteins / Q000737:chemistry; D051379:Mice; D009419:Nerve Tissue Proteins / Q000737:chemistry; D024041:Non-Fibrillar Collagens / Q000737:chemistry; D051190:Plectin / Q000737:chemistry; D012867:Skin / Q000254:growth & development; D012872:Skin Diseases, Vesiculobullous / Q000473:pathology; D014945:Wound Healing; D000097805:Collagen Type XVII
chemical_list: D001324:Autoantigens; D002352:Carrier Proteins; D024143:Collagen Type VII; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D019812:Heparan Sulfate Proteoglycans; D016023:Integrins; D007797:Laminin; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D051190:Plectin; D000097805:Collagen Type XVII; C486268:DST protein, human; C029967:nidogen; C071927:perlecan