title: HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance.
abstract: HVEM is a member of the TNF receptor superfamily that plays a role in the development of various inflammatory diseases. In this study, we show that HVEM deficiency attenuates adipose tissue inflammatory responses and glucose intolerance in diet-induced obesity. Feeding a high-fat diet (HFD) to HVEM-deficient mice elicited a reduction in the number of macrophages and T cells infiltrated into adipose tissue. Proinflammatory cytokine levels in the adipose tissue decreased in HFD-fed HVEM-deficient mice, while levels of the anti-inflammatory cytokine IL-10 increased. Moreover, glucose intolerance and insulin sensitivity were markedly improved in the HFD-fed HVEM-deficient mice. These findings indicate that HVEM may be a useful target for combating obesity-induced inflammatory responses and insulin resistance.
authors.affiliation: Department of Food Science and Nutrition, University of Ulsan, Ulsan, South Korea.
authors.forename: Ha-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Chu-Sook
authors.initials: CS
authors.lastname: Kim
authors.forename: Choon-Soo
authors.initials: CS
authors.lastname: Jeong
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Choi
authors.forename: Teruo
authors.initials: T
authors.lastname: Kawada
authors.forename: Byung-Sam
authors.initials: BS
authors.lastname: Kim
authors.forename: Rina
authors.initials: R
authors.lastname: Yu
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000378:metabolism; D000273:Adipose Tissue / Q000503:physiopathology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D018149:Glucose Intolerance; D007249:Inflammation / Q000503:physiopathology*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D051379:Mice; D009765:Obesity / Q000503:physiopathology; D053240:Receptors, Tumor Necrosis Factor, Member 14 / Q000172:deficiency*
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D004041:Dietary Fats; D007328:Insulin; D053240:Receptors, Tumor Necrosis Factor, Member 14; C506029:Tnfrsf14 protein, mouse