title: Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients.
abstract: Psoriasis is associated with an increase of Th17 cytokines, such as IL-17, IL-22, IL-21, and TNF-α, which are produced by Th17 cells. Adipokines are peptide hormones or cytokines secreted from adipose tissues and involved in the pathogenesis of metabolic syndrome (MS). Psoriasis patients have a high prevalence of the MS. In this study, we investigated the statistics of circulating Th17-related cytokines and adipokines in psoriasis patients. Our study identified the significant elevation of serum IL-6, IL-21, IL-22, and resistin levels in psoriasis patients. Increased serum levels of IL-22 and adiponectin were positively correlated with Psoriasis Area and Severity Index (PASI). In contrast, serum high molecular weight adiponectin levels were decreased in psoriasis and negatively correlated with PASI.
authors.affiliation: Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, 783-8505, Japan. nakajima@kochi-u.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakajima
authors.forename: Kimiko
authors.initials: K
authors.lastname: Nakajima
authors.forename: Masahito
authors.initials: M
authors.lastname: Tarutani
authors.forename: Ryuji
authors.initials: R
authors.lastname: Morishige
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Sano
mesh_terms: D054392:Adipokines / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D005786:Gene Expression Regulation; D006801:Humans; D011565:Psoriasis / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D012720:Severity of Illness Index; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D054392:Adipokines; D016207:Cytokines