title: The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale.
abstract: In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione (1), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its (1)HNMR, (13)C-NMR, and (1)H-(1)H COSY, HMBC, HMQC and NOESY, more precise structure, compared with its originally proposed structures, of [10]-dehydrogingerdione has been elucidated. This active compound inhibited human plasma CETP with IC(50) values of 35 μM.
authors.affiliation: Department of Biotechnology, Hannam University, Daejeon 305-811, Korea.
authors.forename: Soon-Yong
authors.initials: SY
authors.lastname: Choi
authors.forename: Gil-Soon
authors.initials: GS
authors.lastname: Park
authors.forename: Sung Yoon
authors.initials: SY
authors.lastname: Lee
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Young Kook
authors.initials: YK
authors.lastname: Kim
mesh_terms: D000924:Anticholesteremic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D055808:Drug Discovery; D020939:Zingiber officinale / Q000737:chemistry*; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry*
chemical_list: C561631:(10)-dehydrogingerdione; D000924:Anticholesteremic Agents; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D010936:Plant Extracts; D006139:Guaiacol