title: Biodistribution of amino-functionalized diamond nanoparticles. In vivo studies based on 18F radionuclide emission.
abstract: Nanoparticles have been proposed for several biomedical applications; however, in vivo biodistribution studies to confirm their potential are scarce. Nanodiamonds are carbon nanoparticles that have been recently proposed as a promising biomaterial. In this study, we labeled nanodiamonds with (18)F to study their in vivo biodistribution by positron emission tomography. Moreover, the impact on the biodistribution of their kinetic particle size and of the surfactant agents has been evaluated. Radiolabeled diamond nanoparticles accumulated mainly in the lung, spleen, and liver and were excreted into the urinary tract. The addition of surfactant agents did not lead to significant changes in this pattern, with the exception of a slight reduction in the urinary excretion rate. On the other hand, after filtration of the radiolabeled diamond nanoparticles to remove those with a larger kinetic size, the uptake in the lung and spleen was completely inhibited and significantly reduced in the liver.
authors.affiliation: Institut d'Alta Tecnologia-Parc de Recerca Biomèdica de Barcelona, CRC Corporació Sanitària, 08003 Barcelona, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Rojas
authors.forename: Juan D
authors.initials: JD
authors.lastname: Gispert
authors.forename: Roberto
authors.initials: R
authors.lastname: Martín
authors.forename: Sergio
authors.initials: S
authors.lastname: Abad
authors.forename: Cristina
authors.initials: C
authors.lastname: Menchón
authors.forename: Deborah
authors.initials: D
authors.lastname: Pareto
authors.forename: Víctor M
authors.initials: VM
authors.lastname: Víctor
authors.forename: Mercedes
authors.initials: M
authors.lastname: Alvaro
authors.forename: Hermenegildo
authors.initials: H
authors.lastname: García
authors.forename: J Raúl
authors.initials: JR
authors.lastname: Herance
mesh_terms: D000818:Animals; D005462:Fluorine Radioisotopes; D006861:Hydrogen Peroxide / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D007553:Isotope Labeling; D008297:Male; D058612:Nanodiamonds / Q000737:chemistry*; D010316:Particle Size; D049268:Positron-Emission Tomography; D051381:Rats; D017207:Rats, Sprague-Dawley; D013501:Surface-Active Agents / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: C045076:Fenton's reagent; D005462:Fluorine Radioisotopes; D058612:Nanodiamonds; D013501:Surface-Active Agents; D006861:Hydrogen Peroxide; D007501:Iron