title: An entry to curcuphenol/elvirol core structures via a retro-Aldol reaction.
abstract: Analogs of curcuphenol/elvirol, naturally occurring bisabolane sesquiterpenes, were prepared in six steps from alkyl-α-tetralones employing an aromatization reaction of cyclic dienone precursors and olefination of the key aldehyde intermediates. The in vitro antifungal activities of 6a, 6b, 6d, and 6g are also reported.
authors.affiliation: Instituto de Química Rosario (IQUIR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK-Rosario, Argentina.
authors.forename: María F
authors.initials: MF
authors.lastname: Plano
authors.forename: Guillermo R
authors.initials: GR
authors.lastname: Labadie
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Jacob
authors.forename: Babu L
authors.initials: BL
authors.lastname: Tekwani
authors.forename: Raquel M
authors.initials: RM
authors.lastname: Cravero
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003500:Cyclization; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000935:Antifungal Agents; D012717:Sesquiterpenes; C054389:curcuphenol; C116609:3-hydroxybutanal