title: Novel strategies for the development of a vaccine for Parietaria allergy.
abstract: Specific immunotherapy is a well established and clinically proved strategy to cure allergic reactions. The impressive boost of knowledge derived from DNA recombinant technology applied to this field allowed the identification, cloning and expression of several clinically relevant allergens. Recombinant allergens can be easily produced in a pure and reproducible way with immunological properties comparable to natural allergens and matching the requirements of pharmaceutical companies. Parietaria pollinosis is a major health problem in the Mediterranean basin with prolonged symptoms. In this review we will discuss the rational approaches to design hypoallergenic derivatives of the major allergens of this pollen, their immunological properties and possible clinical future implications.
authors.forename: A
authors.initials: A
authors.lastname: Bonura
authors.forename: P
authors.initials: P
authors.lastname: Colombo
mesh_terms: D000485:Allergens / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use*; D000818:Animals; D052179:Antigens, Plant / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use*; D003001:Cloning, Molecular; D003888:Desensitization, Immunologic; D015195:Drug Design; D006801:Humans; D032403:Parietaria / Q000276:immunology*; D011487:Protein Conformation; D011994:Recombinant Proteins / Q000627:therapeutic use; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D013329:Structure-Activity Relationship; D014612:Vaccines / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D011994:Recombinant Proteins; D014612:Vaccines