title: Hsp70 expression as biomarkers of oxidative stress: mycotoxins' exploration.
abstract: The environment represents a key contributor to human health and disease. Exposure to many substances such as pollutants, toxins and chemicals, has detrimental effects on health and are considered to contribute substantially to most diseases of major public health significance. Environmental diseases as mycotoxicosis are those in general aroused or exacerbated by exposure to environmental stressors as mycotoxins. These hazardous compounds are secondary metabolites produced by fungi and occurred simultaneously in food, feed and raw materials. The present investigation was conducted to assess if (i) Hsp70 induction, a parameter of protective and adaptive response, is a systematic biomarker to mycotoxin intoxications and (ii) all mycotoxins undergo oxidative stress in there toxic signalling pathways, as the omnipresent process playing a role in the initiation or progression of numerous disorders. Overall, observations to date evoke that Hsp70 can act as biomarkers of oxidative injury instead they are not systematic to mycotoxin exposure.
authors.affiliation: Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir 5000, Tunisia. emnagol@yahoo.fr
authors.forename: Emna
authors.initials: E
authors.lastname: El Golli-Bennour
authors.forename: Hassen
authors.initials: H
authors.lastname: Bacha
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D015651:Mycotoxicosis / Q000378:metabolism; D009183:Mycotoxins / Q000633:toxicity*; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins; D009183:Mycotoxins