title: Lowering apolipoprotein CIII delays onset of type 1 diabetes.
abstract: Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that apoCIII was also increased in sera from prediabetic rats. This increase in apoCIII promoted β-cell death. The endogenous levels of apoCIII were reduced by treating prediabetic animals with an antisense against this apolipoprotein, resulting in a significantly delayed onset of diabetes. ApoCIII thus serves as a diabetogenic factor, and intervention with this apolipoprotein in the prediabetic state can arrest disease progression. These findings suggest apoCIII as a target for the treatment of type 1 diabetes.
authors.affiliation: The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
authors.forename: Rebecka
authors.initials: R
authors.lastname: Holmberg
authors.forename: Essam
authors.initials: E
authors.lastname: Refai
authors.forename: Anders
authors.initials: A
authors.lastname: Höög
authors.forename: Rosanne M
authors.initials: RM
authors.lastname: Crooke
authors.forename: Mark
authors.initials: M
authors.lastname: Graham
authors.forename: Gunilla
authors.initials: G
authors.lastname: Olivecrona
authors.forename: Per-Olof
authors.initials: PO
authors.lastname: Berggren
authors.forename: Lisa
authors.initials: L
authors.lastname: Juntti-Berggren
mesh_terms: D017668:Age of Onset; D000818:Animals; D053305:Apolipoprotein C-III / Q000097:blood*; D001483:Base Sequence; D003470:Culture Media; D017931:DNA Primers; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism; D051381:Rats; D011913:Rats, Inbred BB
chemical_list: D053305:Apolipoprotein C-III; D003470:Culture Media; D017931:DNA Primers; D007328:Insulin