title: Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population.
abstract: Atopic dermatitis is a chronic, relapsing form of inflammatory skin disorder that is affected by genetic and environmental factors. We performed a genome-wide association study of atopic dermatitis in a Chinese Han population using 1,012 affected individuals (cases) and 1,362 controls followed by a replication study in an additional 3,624 cases and 12,197 controls of Chinese Han ethnicity, as well as 1,806 cases and 3,256 controls from Germany. We identified previously undescribed susceptibility loci at 5q22.1 (TMEM232 and SLC25A46, rs7701890, P(combined) = 3.15 × 10(-9), odds ratio (OR) = 1.24) and 20q13.33 (TNFRSF6B and ZGPAT, rs6010620, P(combined) = 3.0 × 10(-8), OR = 1.17) and replicated another previously reported locus at 1q21.3 (FLG, rs3126085, P(combined) = 5.90 × 10(-12), OR = 0.82) in the Chinese sample. The 20q13.33 locus also showed evidence for association in the German sample (rs6010620, P = 2.87 × 10(-5), OR = 1.25). Our study identifies new genetic susceptibility factors and suggests previously unidentified biological pathways in atopic dermatitis.
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Liang-Dan
authors.initials: LD
authors.lastname: Sun
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authors.forename: Wen-Ming
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authors.lastname: Zhou
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authors.lastname: Hu
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authors.forename: Yan-Hong
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authors.lastname: Zhang
authors.forename: Jian-Ping
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authors.lastname: Tang
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authors.lastname: Wang
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authors.lastname: Chen
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authors.lastname: Ma
authors.forename: Shu-Mei
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authors.lastname: Zhang
authors.forename: Ai-Ping
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authors.lastname: Jiang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zheng
authors.forename: Xing-Hua
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authors.lastname: Gao
authors.forename: Pan
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authors.lastname: Li
authors.forename: Cai-Xia
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authors.lastname: Tu
authors.forename: Xian-Yong
authors.initials: XY
authors.lastname: Yin
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Han
authors.forename: Yun-Qing
authors.initials: YQ
authors.lastname: Ren
authors.forename: Shun-Peng
authors.initials: SP
authors.lastname: Song
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Lu
authors.forename: Xing-Lian
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authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.forename: Jing
authors.initials: J
authors.lastname: Chang
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.forename: Xiao-Yan
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authors.lastname: Luo
authors.forename: Pei-Guang
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authors.lastname: Wang
authors.forename: Xing
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authors.lastname: Dai
authors.forename: Wei
authors.initials: W
authors.lastname: Su
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Chun-Pin
authors.initials: CP
authors.lastname: Shen
authors.forename: Sheng-Xiu
authors.initials: SX
authors.lastname: Liu
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Feng
authors.forename: Chun-Jun
authors.initials: CJ
authors.lastname: Yang
authors.forename: Guo-Shu
authors.initials: GS
authors.lastname: Lin
authors.forename: Zai-Xing
authors.initials: ZX
authors.lastname: Wang
authors.forename: Jian-Qing
authors.initials: JQ
authors.lastname: Huang
authors.forename: Xing
authors.initials: X
authors.lastname: Fan
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yi-Xiao
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authors.lastname: Bao
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: Jian-Jun
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authors.lastname: Liu
authors.forename: Andre
authors.initials: A
authors.lastname: Franke
authors.forename: Stephan
authors.initials: S
authors.lastname: Weidinger
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Yao
authors.forename: Xue-Jun
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authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics*; D000091344:Filaggrin Proteins; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis; D012307:Risk Factors