title: Selective non zinc binding inhibitors of MMP13.
abstract: Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom.
authors.affiliation: AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: De Savi
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Morley
authors.forename: Attilla
authors.initials: A
authors.lastname: Ting
authors.forename: Ian
authors.initials: I
authors.lastname: Nash
authors.forename: Kostas
authors.initials: K
authors.lastname: Karabelas
authors.forename: Christine M
authors.initials: CM
authors.lastname: Wood
authors.forename: Michael
authors.initials: M
authors.lastname: James
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Norris
authors.forename: Galith
authors.initials: G
authors.lastname: Karoutchi
authors.forename: Neil
authors.initials: N
authors.lastname: Rankine
authors.forename: Gordon
authors.initials: G
authors.lastname: Hamlin
authors.forename: Philip A
authors.initials: PA
authors.lastname: Macfaul
authors.forename: David
authors.initials: D
authors.lastname: Ryan
authors.forename: Sarah V
authors.initials: SV
authors.lastname: Baker
authors.forename: David
authors.initials: D
authors.lastname: Hargreaves
authors.forename: Stefan
authors.initials: S
authors.lastname: Gerhardt
mesh_terms: D001665:Binding Sites; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D053509:Matrix Metalloproteinase 13 / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D015032:Zinc / Q000737:chemistry*
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D053509:Matrix Metalloproteinase 13; D015032:Zinc