title: [Effects of magnesium supplementation on calcium and magnesium levels, and redox homeostasis in normolipidemic and food-induced hyperlipidemic rats].
abstract: Magnesium supplementation is quite popular because of intention of health and healthy lifestyle. However, there is no information on the metabolic effects of magnesium supplementation in healthy people and in different diseases.
  
  
  OBJECTIVE
  Authors examined the effects of magnesium-malate on calcium, magnesium levels, and antioxidant parameters in normolipidemic and hyperlipidemic rats.
  
  
  METHODS
  Male Wistar rats (n = 40; 150-200 g) were divided into 4 groups (control, control-treated, hyperlipidemic, hyperlipidemic-treated). Rats in the control and control-treated groups were fed with normal diet, while hyperlipidemic and hyperlipidemic-treated groups were fed with fat rich diet (2% cholesterol, 20% sunflower oil, 0.5% cholic acid). After the 9-day-long diet the following parameters were measured: routine laboratory parameters with automatic analysator, metal content using ICP-OES, and redox-parameters using spectrophotometric and luminometric methods.
  
  
  RESULTS
  Magnesium-malate failed to produce significant changes in the measured parameters in control animals in most cases. Magnesium-malate decreased significantly serum glucose concentration, alkaline phosphatase and amylase activities in the hyperlipidemic group. Significantly low induced chemiluminescent activity was measured in the plasma and erythrocytes of hyperlipidemic group. The magnesium supplementation did not increase significantly magnesium concentration in different organs although the calcium/magnesium concentration ratio was decreased.
  
  
  CONCLUSIONS
  In control animals there was no significant change in the measured parameters in most cases after dietary supplementation with a large amount of magnesium for a short period of time, but magnesium supplementation affected the metal homeostasis, routine laboratory parameters and redox system in hyperlipidemic animals. Although several changes were favorable, it should be emphasized that magnesium supplementation must be applied watchfully particularly in metabolic diseases.
authors.affiliation: Magyar Tudományos Akadémia, Kémiai Kutatóközpont Anyag- és Környezetkémiai Intézet Budapest Pusztaszeri út 59-67. 1025. viragviki@yahoo.com
authors.forename: Viktória
authors.initials: V
authors.lastname: Virág
authors.forename: Zoltán
authors.initials: Z
authors.lastname: May
authors.forename: Ibolya
authors.initials: I
authors.lastname: Kocsis
authors.forename: Anna
authors.initials: A
authors.lastname: Blázovics
authors.forename: Klára
authors.initials: K
authors.lastname: Szentmihályi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D017610:Calcium Compounds / Q000097:blood / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage; D019587:Dietary Supplements; D006706:Homeostasis / Q000187:drug effects; D006949:Hyperlipidemias / Q000097:blood*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism*; D017616:Magnesium Compounds / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D017610:Calcium Compounds; D004041:Dietary Fats; D008055:Lipids; D017616:Magnesium Compounds