title: Turning reciprocal feedback regulation into combination therapy.
abstract: Two recent Cancer Cell articles report the discovery of reciprocal feedback regulation between androgenic and PTEN loss/PI3K-AKT signaling in prostate cancer. Both studies link endocrine regulation with a common oncogenic pathway, which led to the development of a combination therapeutic approach with immediate application in prostate cancer.
authors.affiliation: Department of Genitourinary Medical Oncology-Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA. timthomp@mdanderson.org
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Thompson