title: Cysteine peptidases of kinetoplastid parasites.
abstract: We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage-specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and pathogenesis and modulation of the host's immune response. Their applications as vaccine candidates and diagnostic markers as well as their chemical and genetic validation as drug targets are also summarized.
authors.affiliation: Sandler Center for Drug Discovery, California Institute for Quantitative Biosciences, Byers Hall, University of California San Francisco, San Francisco, USA. caffrey@cgl.ucsf.edu
authors.forename: Conor R
authors.initials: CR
authors.lastname: Caffrey
authors.forename: Ana-Paula
authors.initials: AP
authors.lastname: Lima
authors.forename: Dietmar
authors.initials: D
authors.lastname: Steverding
mesh_terms: D000818:Animals; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000378:metabolism*; D007155:Immunologic Factors / Q000276:immunology; D007891:Leishmania / Q000201:enzymology* / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D010271:Parasites / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity; D016052:Protozoan Vaccines / Q000276:immunology; D014345:Trypanosoma / Q000201:enzymology* / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity
chemical_list: D007155:Immunologic Factors; D016052:Protozoan Vaccines; D003546:Cysteine Endopeptidases