title: MAPS: an interactive web server for membrane annotation of transmembrane protein structures.
abstract: The exact positioning of the membrane in transmembrane (TM) proteins plays important functional roles. Yet, the structures of TM proteins in protein data bank (pdb) have no information about the explicit position of the membrane. Using a simple hydrophobic lipid-protein mismatch energy function and a flexible lipid/water boundary, the position of lipid bilayer for representative TM proteins in pdb have been annotated. A web server called MAPS (Membrane Annotation of Protein Structures; available at: http://www.boseinst.ernet.in/gautam/maps) has been set up that allows the user to interactively analyze membrane-protein orientations of any uploaded pdb structure with user-defined membrane flexibility parameters.
authors.affiliation: Department of Biophysics, Bose Institute, P-1/12 CIT Scheme VIIM, Kolkata 700 054, India. jitender.cheema@bbsrc.ac.uk
authors.forename: Jitender
authors.initials: J
authors.lastname: Cheema
authors.forename: Gautam
authors.initials: G
authors.lastname: Basu
mesh_terms: D000465:Algorithms; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism; D019295:Computational Biology / Q000193:education / Q000379:methods*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D020407:Internet; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D058977:Molecular Sequence Annotation; D014584:User-Computer Interface
chemical_list: D008051:Lipid Bilayers; D008565:Membrane Proteins