title: [A study on expression of Wnt signal pathway gene in familial aggregated hypertension].
abstract: OBJECTIVE
  To determine the role of gene expression of Wnt signal pathway in the pathogenesis of familial aggregated hypertension.
  
  
  METHODS
  The patients having directly related family members for more than three generations suffering from hypertension were enlisted in the hypertension group, and healthy individuals served as control group. The real-time polymerase chain reaction (PCR) gene array was used to detect the expression of functional classification genes of Wnt signal pathway in peripheral blood, with standard value deviated>2.0 from hypertension group/control group as differential genes.
  
  
  RESULTS
  When hypertension group was compared with the control group, there were 6 differentially expressed genes, with 5 genes up-regulated, including Bcl-9, microphthalmia associated transcription factor (Mitf), secreted frizzled-related protein-1 (Sfrp-1), Wnt inhibiting factor-1 (Wif-1) and ribosomal protein-l13a (Rp-l13a). There was 1 gene down-regulated, i.e. dickkopf homolog-3 (Dkk-3).
  
  
  CONCLUSIONS
  The result of this study suggested that the Wnt signal pathway may be related to the occurrence and development of the familial aggregated hypertension.
authors.affiliation: Department of Cardiology, Dingxi City Second People's Hospital, Dingxi 743000, Gansu, China.
authors.forename: Po
authors.initials: P
authors.lastname: Zhang
authors.forename: Zhi-lu
authors.initials: ZL
authors.lastname: Wang
authors.forename: Shou-lan
authors.initials: SL
authors.lastname: Shi
authors.forename: Zeng-ying
authors.initials: ZY
authors.lastname: Wu
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Xiong
authors.forename: Xiao-fang
authors.initials: XF
authors.lastname: Yang
authors.forename: Ji-lin
authors.initials: JL
authors.lastname: Ma
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D051153:Wnt Proteins / Q000235:genetics* / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000235:genetics*
chemical_list: D051153:Wnt Proteins