title: Changing pathology with changing drugs: skin cancer.
abstract: Today skin cancer is mainly treated by surgical interventions. New findings concerning molecular biology and the signaling pathways in epithelial skin cancers such as basal cell carcinoma, squamous cell carcinoma or melanoma, and mesenchymal skin cancers such as angiosarcoma and dermatofibrosarcoma protuberans (DFSP) have identified new molecular targets for a systemic or local treatment approach. For DFSP there is an opportunity already today to reduce the intensity of surgical procedures by pretreatment with targeted therapy. This article highlights important aspects in several skin cancer types.
authors.affiliation: Department of Dermatology, University Hospital of Zürich, Switzerland. maria.karpova@usz.ch
authors.forename: M B
authors.initials: MB
authors.lastname: Karpova
authors.forename: M J
authors.initials: MJ
authors.lastname: Barysch
authors.forename: M C
authors.initials: MC
authors.lastname: Zipser
authors.forename: N
authors.initials: N
authors.lastname: Schönewolf
authors.forename: L E
authors.initials: LE
authors.lastname: French
authors.forename: R
authors.initials: R
authors.lastname: Dummer
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D018223:Dermatofibrosarcoma / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D058990:Molecular Targeted Therapy / Q000379:methods*; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D057170:Translational Research, Biomedical
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors