title: Resurgent Na+ current: a new avenue to neuronal excitability control.
abstract: Integrative and firing properties are important characteristics of neuronal circuits and these responses are determined in large part by the repertoire of ion channels they express, which can vary considerably between cell types. Recently, a new mode of operation of voltage dependent sodium channels has been described that generates a so-called resurgent Na+ current. Accumulating evidence suggests resurgent Na current participates in the generation of sub-threshold inward Na+ current causing membrane depolarization which provides the necessary drive to fire high-frequency action potentials. Recent studies indicate that resurgent Na+ current could be a more widespread feature than previously thought.
authors.affiliation: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil. jcruz@icb.ufmg.br
authors.forename: Jader S
authors.initials: JS
authors.lastname: Cruz
authors.forename: Darizy F
authors.initials: DF
authors.lastname: Silva
authors.forename: Luciano A
authors.initials: LA
authors.lastname: Ribeiro
authors.forename: Islânia G A
authors.initials: IG
authors.lastname: Araújo
authors.forename: Nayara
authors.initials: N
authors.lastname: Magalhães
authors.forename: Alessandra
authors.initials: A
authors.lastname: Medeiros
authors.forename: Christiane
authors.initials: C
authors.lastname: Freitas
authors.forename: Izabella C
authors.initials: IC
authors.lastname: Araujo
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D055724:Electrophysiological Phenomena; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D062557:NAV1.6 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D015222:Sodium Channels / Q000502:physiology*
chemical_list: D062557:NAV1.6 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins; C100681:SCN8A protein, human; D015222:Sodium Channels