title: Impact of nasal polyposis on erectile dysfunction.
abstract: BACKGROUND
  Our male patients with chronic rhinosinusitis with nasal polyposis (NP) declare a better sexual function after functional endoscopic sinus surgery (FESS) with polypectomy. This study was planned to conduct the first prospective, controlled trial evaluating the possible relation between erectile dysfunction (ED) and NP by subjective and objective parameters.
  
  
  METHODS
  Thirty-three male patients with NP and thirty randomly selected male control subjects were evaluated. All subjects underwent assessments of nasal endoscopy, rhinomanometry, body mass index (BMI), Epworth Sleepiness Scale, full in-laboratory polysomnograpy and serum levels of glucose, thyroid hormones, lipid profile, and testosterone. ED was evaluated by the erectile function domain of the International Index of Erectile Function (IIEF-EF) subjectively and nocturnal penile tumescence (NPT) objectively. The NP group was reassessed 6 months after FESS.
  
  
  RESULTS
  The mean age, BMI, and laboratory tests of the patients and the control subjects had no significant difference. The well-recognized risk factors for ED were eliminated. Preoperative evaluation of the patients revealed that ED was present in 34 and 24% of the patients by IIEF-EF and NPT, respectively, which was significantly higher than the control group (p = 0.009 and p = 0.018, respectively). There was a significant improvement of ED in the assessment of IIEF-EF and NPT postoperatively (p = 0.014 and p = 0.037, respectively).
  
  
  CONCLUSIONS
  ED was determined in a high percentage of patients with NP and significantly ameliorated after FESS. NP might present a risk factor in the development of ED.
authors.affiliation: Department of Otorhinolaryngology, Celal Bayar University, Manisa, Turkey. kivanc.gunhan@bayar.edu.tr
authors.forename: Kivanc
authors.initials: K
authors.lastname: Gunhan
authors.forename: Fatih
authors.initials: F
authors.lastname: Zeren
authors.forename: Uzdan
authors.initials: U
authors.lastname: Uz
authors.forename: Bilal
authors.initials: B
authors.lastname: Gumus
authors.forename: Halis
authors.initials: H
authors.lastname: Unlu
mesh_terms: D000328:Adult; D002908:Chronic Disease; D018450:Disease Progression; D004724:Endoscopy; D007172:Erectile Dysfunction / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps; D010410:Penile Erection; D017286:Polysomnography; D012220:Rhinitis / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D025363:Rhinomanometry; D012852:Sinusitis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone