title: On-line reaction monitoring of lithiation of halogen substituted acetanilides via in situ calorimetry, ATR spectroscopy, and endoscopy.
abstract: Lithiation of N-(4-chlorophenyl)-pivalamide (NCP) and two additional substituted acetanilides: 4-fluoroacetanilide (4-F) and 4-chloroacetanilide (4-Cl) has been monitored by means of calorimetry, on-line ATR-IR and UV/vis spectroscopy and endoscopy. The combined on-line monitoring revealed the differences between the reaction paths of the chosen substrates. Thus the product structure and the reaction times for the individual reaction steps can be determined in situ.
authors.affiliation: Institute for Chemical and Bioengineering, ETH Zürich, Wolfgang-Pauli Str. 10, HCI G130, CH-8092 Zürich. tamas.godany@chem.ethz.ch
authors.forename: Tamas A
authors.initials: TA
authors.lastname: Godany
authors.forename: Yorck-Michael
authors.initials: YM
authors.lastname: Neuhold
authors.forename: Konrad
authors.initials: K
authors.lastname: Hungerbühler
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D000480:Alkynes; D048588:Benzoxazines / Q000138:chemical synthesis*; D002151:Calorimetry; D003521:Cyclopropanes; D008094:Lithium / Q000737:chemistry; D055601:Organic Chemistry Phenomena; D013055:Spectrophotometry, Infrared / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
chemical_list: D000083:Acetanilides; D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; C118946:4-fluoroacetanilide; C012241:4-chloroacetanilide; D008094:Lithium; C098320:efavirenz