title: Antivirulence potential of TR-700 and clindamycin on clinical isolates of Staphylococcus aureus producing phenol-soluble modulins.
abstract: Staphylococcus aureus strains (n = 50) causing complicated skin and skin structure infections produced various levels of phenol-soluble modulin alpha-type (PSMα) peptides; some produced more than twice that produced by the control strain (LAC USA300). TR-700 (oxazolidinone) and clindamycin strongly inhibited PSM production at one-half the MIC but exhibited weak to modest induction at one-fourth and one-eighth the MICs, primarily in low producers. Adequate dosing of these agents is emphasized to minimize the potential for paradoxical induction of virulence.
authors.affiliation: University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Yamaki
authors.forename: Timothy
authors.initials: T
authors.lastname: Synold
authors.forename: Annie
authors.initials: A
authors.lastname: Wong-Beringer
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000378:metabolism*; D002981:Clindamycin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism*; D013777:Tetrazoles / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D023303:Oxazolidinones; D013777:Tetrazoles; C025971:staphylococcal delta toxin; D002981:Clindamycin; C546016:tedizolid