title: Linseed oil: an investigation of its antiarthritic activity in experimental models.
abstract: Food sources rich in omega-3 fatty acids have been valued for their beneficial effect in the management of inflammatory disorders. The present study evaluates the antiarthritic and immunomodulatory activity of Linum usitatissimum fixed oil (LUFO) in experimental models. The LUFO produced a dose-dependent reduction in joint swelling and circulating TNF-α levels in both preventive and curative protocols of arthritis induced by complete Freund's adjuvant (CFA). Expression of TNF-R1 and Interleukin (IL) 6 proteins in the arthritic paw was also significantly reduced in the LUFO-treated animals. In the cotton pellet induced granuloma model, LUFO treatment significantly reduced the dry granuloma weight as compared with the control group. Results of our present study thus demonstrate the antiarthritic and disease modifying activity of LUFO. We believe that dietary incorporation of LUFO may be beneficial in the prevention and management of rheumatoid arthritis and other chronic inflammatory disorders.
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. surenderaiims@gmail.com
authors.forename: Surender
authors.initials: S
authors.lastname: Singh
authors.forename: Vinod
authors.initials: V
authors.lastname: Nair
authors.forename: Y K
authors.initials: YK
authors.lastname: Gupta
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D019597:Flax / Q000737:chemistry; D005620:Freund's Adjuvant / Q000009:adverse effects; D006099:Granuloma / Q000188:drug therapy; D015850:Interleukin-6 / Q000378:metabolism; D008043:Linseed Oil / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism; D012639:Seeds / Q000737:chemistry; D023382:Toxicity Tests, Acute; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha; D008043:Linseed Oil; D005620:Freund's Adjuvant