title: Mycotic aneurysm of the aorta as a complication of Bacillus Calmette-Guérin instillation.
abstract: Bacillus Calmette-Guérin (BCG) is a live attenuated strain of Mycobacterium bovis that has been widely used for the treatment of superficial transitional cell carcinoma of the bladder. We describe a rare case of supra-renal mycotic aortic aneurysm secondary to BCG instillation in a 75-year-old male. Patients presenting with systemic symptoms post-instillation, possibly with an aneurysm, should raise suspicion of BCG dissemination, which requires early instigation of anti-mycobacterial drugs.
authors.affiliation: Department of Nephrology, University Hospital of North Staffordshire, Royal Infirmary, Princess Road, Stoke on Trent, Staffordshire, UK.
authors.forename: J
authors.initials: J
authors.lastname: Maundrell
authors.forename: S
authors.initials: S
authors.lastname: Fletcher
authors.forename: P
authors.initials: P
authors.lastname: Roberts
authors.forename: A
authors.initials: A
authors.lastname: Stein
authors.forename: M
authors.initials: M
authors.lastname: Lambie
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D000785:Aneurysm, Infected / Q000209:etiology* / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D001012:Aorta, Abdominal / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D017544:Aortic Aneurysm, Abdominal / Q000209:etiology* / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D001500:BCG Vaccine / Q000009:adverse effects*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000382:microbiology; D004739:England; D004977:Ethambutol / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D009164:Mycobacterium Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D009163:Mycobacterium bovis / Q000187:drug effects; D012293:Rifampin / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000904:Antibiotics, Antitubercular; D001500:BCG Vaccine; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin