title: Multimodal neurophysiological and psychometric evaluation among patients with systemic lupus erythematosus.
abstract: OBJECTIVE
  To determine some of the neuropsychiatric manifestations of systemic lupus erythematosus (SLE) by applying multimodal neurophysiological and psychometric studies.
  
  
  METHODS
  Twenty-six SLE patients were evaluated for neurological and psychiatric disorders and compared with 26 healthy controls matched for age, sex, education, and social class. The severity of SLE disease was assessed. Each subject was subjected to the following examinations: laboratory, neurophysiology, magnetic resonance imaging of the brain, transcranial duplex, Modified Mini-mental State Examination, Cognitive Assessment Scale Inventory, Hamilton Depression Scale, and Hamilton Anxiety Scale.
  
  
  RESULTS
  The mean age of subjects was 25.9 ± 8.9 years. The most prevalent neurological manifestations were (in order of frequency) anxiety in 17 cases (65.4%), depression in 15 cases (57.7%), headache in 10 cases (38.5%), peripheral neuropathy in 7 cases (26.9%), seizures in 6 cases (23.1%), psychosis in 5 cases (19.2%), dementia in 4 cases (15.4%), radiculopathy in 4 cases (15.4%), myositis in 3 cases (11.5%), and stroke in 2 cases (7.7%). There was a significant affection in amplitude of the ulnar nerve, cognitive function impairment, and electroencephalography changes. There was a significant increased mean velocity and decreased Pulsatility Index of the most studied intracranial vessels in the patients.
  
  
  CONCLUSIONS
  The use of multimodal neurophysiological, transcranial duplex, and psychometric scales increases the sensitivity for detecting nervous system involvement.
authors.affiliation: Department of Neurology. ghaydaa83@yahoo.com
authors.forename: Ghaydaa A
authors.initials: GA
authors.lastname: Shehata
authors.forename: Yasser Mb
authors.initials: YM
authors.lastname: Elserogy
authors.forename: Hossam Eddin K
authors.initials: HE
authors.lastname: Ahmad
authors.forename: Mohamed I
authors.initials: MI
authors.lastname: Abdel-Kareem
authors.forename: Ashraf M
authors.initials: AM
authors.lastname: Al-Kabeer
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Rayan
authors.forename: Mohamed Es Abd
authors.initials: ME
authors.lastname: El-Baky