title: [Clinical assessment of granulocyte colony-stimulating factor producing lung cancer].
abstract: OBJECTIVE
  The aim of this study was to reveal the clinicopathological feature of granulocyte colony-stimulating factor (G-CSF) producing lung cancer.
  
  
  METHODS
  Nine cases of G-CSF producing lung cancer from July 2003 to July 2008 were retrospectively evaluated.
  
  
  RESULTS
  All cases were male, 8 cases were poorly differentiated carcinoma. Average of leucocyte and serum G-CSF were 23,378/microl and 128.6 pg/ml respectively. Five cases had febrile symptom, average of serum C-reactive protein (CRP) was 13.37 mg/dl. Immunohistological examination showed positive staining for G-CSF in 6 cases. Serum interleukin-6 (IL-6) level was elevated in 3 cases. Clinical stages were IB in 2, IIB in 2, IIIA in 3 and IIIB in 2 patients. Chemotherapy was performed for patients with stage IIIB. Operation was performed for the other cases. Five cases were died within 12 months, whereas 4 cases are surviving for 6 to 16 months.
  
  
  CONCLUSIONS
  Generally, the prognosis of G-CSF producing lung cancer seems to be poor, but in our institute there were 2 cases who lived over 1 year without disease. It is important to establish more effective adjuvant therapy for G-CSF producing tumor.
authors.affiliation: Department of Chest Surgery, Yamaguchi-Ube Medical Center, Ube, Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Matsuda
authors.forename: Kazunori
authors.initials: K
authors.lastname: Okabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tao
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Hirazawa
authors.forename: Seiki
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Murakami
authors.forename: Kazuro
authors.initials: K
authors.lastname: Sugi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D016179:Granulocyte Colony-Stimulating Factor