title: A new Os,Rh bimetallic with O2 independent DNA cleavage and DNA photobinding with red therapeutic light excitation.
abstract: Many Ru and Os systems display photoactive (3)MLCT states. Systems activated by therapeutic window light in the absence of O(2) remain elusive. [(bpy)(2)Os(dpp)RhCl(2)(phen)](3+) photobinds and photocleaves DNA under red light in an oxygen independent manner, due to molecular design involving one Os chromophore coupled to a photoactive cis-Rh(III)Cl(2) moiety.
authors.affiliation: Department of Chemistry, Virginia Tech., Blacksburg, Virginia 24061-0212, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Samantha L H
authors.initials: SL
authors.lastname: Higgins
authors.forename: Brenda S J
authors.initials: BS
authors.lastname: Winkel
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Brewer
mesh_terms: D003116:Color; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects / Q000528:radiation effects*; D004579:Electron Transport; D008027:Light; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D009992:Osmium / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D055668:Photochemical Processes / Q000187:drug effects / Q000528:radiation effects*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D012238:Rhodium / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D009992:Osmium; D004247:DNA; D012238:Rhodium; D010100:Oxygen