title: Successful treatment with adalimumab in a familial case of gastrointestinal Behcet's disease.
abstract: We present here two siblings with a history of recurrent oral and genital ulcers, neurological and gastrointestinal manifestations. The diagnosis of Behçet's disease in a context of familial aggregation was assumed. Facing repeated steroid-dependent flares and failure of maintenance therapies with colchicine and intolerance to pentoxifilline and disulone, adalimumab was started. Rapid response was observed in both patients, with clinical remission after induction therapy, which currently sustains under maintenance schedule. This case report suggests the effectiveness of adalimumab as first anti-TNFα in case of steroid-dependent/resistant gastrointestinal BD.
authors.affiliation: Clinique des Maladies de l'Appareil Digestif et de la Nutrition, Centre Hospitalier Régional Universitaire de Lille, Hôpital Claude Huriez, 59037 Lille, France. chiaradecassan@yahoo.it
authors.forename: Chiara
authors.initials: C
authors.lastname: De Cassan
authors.forename: Bénédicte
authors.initials: B
authors.lastname: De Vroey
authors.forename: Catherine
authors.initials: C
authors.lastname: Dussault
authors.forename: Eric
authors.initials: E
authors.lastname: Hachulla
authors.forename: Sebastien
authors.initials: S
authors.lastname: Buche
authors.forename: Jean-Frédéric
authors.initials: JF
authors.lastname: Colombel
mesh_terms: D000068879:Adalimumab; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D001528:Behcet Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D003424:Crohn Disease / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D061067:Antibodies, Monoclonal, Humanized; D000068879:Adalimumab