title: Automatic classification of 123I-FP-CIT (DaTSCAN) SPECT images.
abstract: BACKGROUND
  We present a method of automatic classification of I-fluoropropyl-carbomethoxy-3β-4-iodophenyltropane (FP-CIT) images. This technique uses singular value decomposition (SVD) to reduce a training set of patient image data into vectors in feature space (D space). The automatic classification techniques use the distribution of the training data in D space to define classification boundaries. Subsequent patients can be mapped into D space, and their classification can be automatically given.
  
  
  METHODS
  The technique has been tested using 116 patients for whom the diagnosis of either Parkinsonian syndrome or non-Parkinsonian syndrome has been confirmed from post I-FP-CIT imaging follow-up. The first three components were used to define D space. Two automatic classification tools were used, naïve Bayes (NB) and group prototype. A leave-one-out cross-validation was performed to repeatedly train and test the automatic classification system. Four commercially available systems for the classification were tested using the same clinical database.
  
  
  RESULTS
  The proposed technique combining SVD and NB correctly classified 110 of 116 patients (94.8%), with a sensitivity of 93.7% and specificity of 97.3%. The combination of SVD and an automatic classifier performed as well or better than the commercially available systems.
  
  
  CONCLUSIONS
  The combination of data reduction by SVD with automatic classifiers such as NB can provide good diagnostic accuracy and may be a useful adjunct to clinical reporting.
authors.affiliation: Radiological Science Unit, Imperial College Healthcare NHS Trust, London, UK. david.towey@imperial.nhs.uk
authors.forename: David J
authors.initials: DJ
authors.lastname: Towey
authors.forename: Peter G
authors.initials: PG
authors.lastname: Bain
authors.forename: Kuldip S
authors.initials: KS
authors.lastname: Nijran
mesh_terms: D001331:Automation; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging; D025341:Principal Component Analysis; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014326:Tropanes
chemical_list: D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane