title: Do shared mechanisms underlying cell cycle regulation and synaptic plasticity underlie the reduced incidence of cancer in schizophrenia?
abstract: Evidence from epidemiology suggests that the incidence of cancer is reduced in those with schizophrenia. Clues that could explain this finding have recently emerged from neuroscience--genes that were previously thought only to be involved in cell cycle regulation have additional functions in post-mitotic neurons related to neuronal migration and synaptic plasticity. This brief communication provides a concise summary of this evidence. We propose that this convergence between epidemiology and neuroscience will provide a more tractable search space for candidate genes, and provide clues for etiopathogenesis of schizophrenia.
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Guang
authors.initials: G
authors.lastname: He
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: John
authors.initials: J
authors.lastname: McGrath
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000473:pathology*; D012559:Schizophrenia / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D013569:Synapses / Q000473:pathology / Q000502:physiology*