title: Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour.
abstract: Data suggest that the serotonin (5-hydroxytryptamine, 5-HT) system is implicated in the pathogenesis of multiple neuropsychiatric disorders and may also be involved in smoking behaviour since nicotine increases brain serotonin secretion. It is known that smoking behaviour is influenced by both genetic and environmental factors. The present review examines the role of the serotonin transporter gene (5-HTT) in smoking behaviour and investigating studies that showed association of 5-HTT gene with smoking. This study discusses a polymorphism which has been investigated by many researchers, as the bi-allelic insertion/deletion polymorphism in the 5'- flanking promoter region (5-HTTLPR). This gene has received considerable attention in attempts to understand the molecular determinants of smoking. Therefore, in the present study, the relationship between genetic polymorphism of serotonin transporter in smoking behaviour is reviewed considering the interactive effect of genetic factors.
authors.affiliation: Laboratory of Molecular Genetics, Department of Pathological Sciences, University Hospital, State University of Londrina, Londrina, Brazil. maewatuel@gmail.com
authors.forename: Maria Angelica Ehara
authors.initials: MA
authors.lastname: Watanabe
authors.forename: Sandra Odebrecht Vargas
authors.initials: SO
authors.lastname: Nunes
authors.forename: Sandra Odebrechet Vargas
authors.initials: SO
authors.lastname: Nunes
authors.forename: Marla Karine
authors.initials: MK
authors.lastname: Amarante
authors.forename: Roberta Losi
authors.initials: RL
authors.lastname: Guembarovski
authors.forename: Julie Massayo Maeda
authors.initials: JM
authors.lastname: Oda
authors.forename: Kalil William Alves De
authors.initials: KW
authors.lastname: Lima
authors.forename: Maria Helena Pelegrinelli
authors.initials: MH
authors.lastname: Fungaro
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics; D016739:Behavior, Addictive / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D054643:INDEL Mutation; D009474:Neurons / Q000378:metabolism; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012701:Serotonin / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012907:Smoking / Q000235:genetics*; D009435:Synaptic Transmission / Q000235:genetics
chemical_list: D020121:5' Untranslated Regions; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin