title: A SirT'N repression for Notch.
abstract: Mulligan et al. (2011) show here that the NAD(+)-dependent SIRT1 (H4K16; H1K26) deacetylase acts in concert with the LSD1 (H3K4) demethylase to repress Notch-induced transcription, thus coupling two distinct histone modifications at a key epigenetic switch for Notch target genes.
authors.affiliation: Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037-1099, USA. jones@salk.edu
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Jones