title: Klotho KL-VS genotype is involved in blood pressure regulation.
abstract: OBJECTIVE
  Genome-wide linkage analysis studies reported the importance of the long arm of chromosome 13 in systolic blood pressure regulation. Therefore, isolating a genetic variant related to this chromosomal region could be challenging. Klotho KL-VS allele is located on this chromosomal region and its relationships with cardio-vascular risk factors need extensive investigations. The aim of the present study is to examine whether the klotho KL-VS genotype is associated with cardio-vascular risk factors, more particularly hypertension, in two independent cohorts. A secondary objective was to investigate relationships with antihypertensive treatment, arterial stiffness and carotid artery parameters.
  
  
  RESULTS
  A total of 1023 French individuals were genotyped for klotho KL-VS. Participants were part of the French ERA and STANISLAS cohorts. In both cohorts, klotho KL-VS/KL-VS genotype was significantly associated with lower systolic blood pressure and pulse pressure when compared to homozygous and heterozygous more frequent (WT) allele carriers (p=0.003 and p<0.001 respectively). Antihypertensive treatment stratification confirmed the previous significant associations, while a significant interaction between klotho KL-VS genotype and antihypertensive treatment was also interestingly found (0.019 for p interaction).
  
  
  CONCLUSIONS
  Klotho KL-VS/KL-VS genotype may be associated with decreased cardio-vascular risk and may interact with antihypertensive treatment in order to reduce blood pressure. This finding could lead to identify subgroups of hypertensive adults who might benefit antihypertensive drug therapies.
authors.affiliation: Department of Internal Medicine and Geriatrics, INSERM U, University of Nancy, France.
authors.forename: Rosine
authors.initials: R
authors.lastname: Nzietchueng
authors.forename: Said
authors.initials: S
authors.lastname: El Shamieh
authors.forename: Hamanou
authors.initials: H
authors.lastname: Benachour
authors.forename: Carlos
authors.initials: C
authors.lastname: Labat
authors.forename: Bernard
authors.initials: B
authors.lastname: Herbeth
authors.forename: Ndeye Coumba
authors.initials: NC
authors.lastname: Ndiaye
authors.forename: Christine
authors.initials: C
authors.lastname: Masson
authors.forename: Sophie
authors.initials: S
authors.lastname: Visvikis-Siest
authors.forename: Athanase
authors.initials: A
authors.lastname: Benetos
mesh_terms: D000368:Aged; D001483:Base Sequence; D001794:Blood Pressure / Q000235:genetics*; D015331:Cohort Studies; D017931:DNA Primers; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D000090265:Klotho Proteins; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D005966:Glucuronidase; D000090265:Klotho Proteins