title: Histological and ultrastructural reaction to different materials for orthopaedic application.
abstract: Prosthetic joints loosening in absence of infection is the most common reason for revision surgery and is known as aseptic loosening. A significant role in the pathogenesis of implant failure undoubtedly played by the generation of wear debris, mainly from the load bearing joint surfaces, and the cellular reaction through the formation of tissue membrane around implants. This article analyzes histologic, immunohistochemical ad ultrastructural aspects of periprosthetic tissue membrane collected at time of surgical revision, paying attention on cell host response to different materials: metals, polyethylene and ceramics. Dimension of particles seems to be crucial in the activation of different cell population to wear debris.
authors.affiliation: Department of Orthopaedics and Traumatology, Catholic University, Rome. valentinadelbravo@libero.it
authors.forename: V
authors.initials: V
authors.lastname: Del Bravo
authors.forename: C
authors.initials: C
authors.lastname: Graci
authors.forename: M S
authors.initials: MS
authors.lastname: Spinelli
authors.forename: F
authors.initials: F
authors.lastname: Muratori
authors.forename: G
authors.initials: G
authors.lastname: Maccauro
mesh_terms: D019644:Arthroplasty, Replacement, Hip; D001672:Biocompatible Materials / Q000009:adverse effects*; D018786:Bone Substitutes; D001842:Bone and Bones / Q000502:physiology* / Q000648:ultrastructure*; D002516:Ceramics / Q000009:adverse effects; D004492:Edetic Acid; D006622:Hip Prosthesis; D006801:Humans; D007150:Immunohistochemistry; D008670:Metals / Q000009:adverse effects; D008855:Microscopy, Electron, Scanning; D019637:Orthopedic Procedures; D020959:Polyethylene / Q000009:adverse effects; D011475:Prosthesis Failure
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D008670:Metals; D020959:Polyethylene; D004492:Edetic Acid