title: Oseltamivir and risk of lower respiratory tract complications in patients with flu symptoms: a meta-analysis of eleven randomized clinical trials.
abstract: An independent reanalysis of 11 randomized clinical trials shows that oseltamivir treatment reduces the risk of lower respiratory tract complications requiring antibiotic treatment by 28% overall (95% confidence interval [CI], 11%-42%) and by 37% among patients with confirmed influenza infections (95% CI, 18%-52%).
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. miguel_hernan@post.harvard.edu
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Hernán
authors.forename: Marc
authors.initials: M
authors.lastname: Lipsitch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000008:administration & dosage*; D018410:Pneumonia, Bacterial / Q000453:epidemiology* / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir