title: Food dependence in rats selectively bred for low versus high saccharin intake. Implications for "food addiction".
abstract: The "food addiction" concept implies that proneness to drug dependence and to food dependence should covary. The latter was studied in low- (LoS) and high- (HiS) saccharin-consuming rats, who differ in drug self-administration (HiS>LoS) and withdrawal (LoS>HiS). Sugary food intake in the first 1-2 h was higher in HiS than LoS rats. Sugar intake predicted startle during abstinence only among LoS rats. These results may suggest bingeing-proneness in HiS rats and withdrawal-proneness among LoS rats. However, intake escalation and somatic withdrawal did not differ between lines. Further study with selectively bred rats, with attention to definitions and measures, is warranted.
authors.affiliation: Occidental College, USA.
authors.forename: Veronica
authors.initials: V
authors.lastname: Yakovenko
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Speidel
authors.forename: Clinton D
authors.initials: CD
authors.lastname: Chapman
authors.forename: Nancy K
authors.initials: NK
authors.lastname: Dess
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000235:genetics*; D004040:Dietary Carbohydrates; D000431:Ethanol; D005260:Female; D005947:Glucose; D010641:Phenotype; D051381:Rats; D011919:Rats, Inbred Strains; D013216:Reflex, Startle; D012439:Saccharin / Q000008:administration & dosage*; D012646:Self Administration
chemical_list: D004040:Dietary Carbohydrates; D000431:Ethanol; D012439:Saccharin; D005947:Glucose