title: Synthesis and in vitro protein tyrosine kinase inhibitory activity of furan-2-yl(phenyl)methanone derivatives.
abstract: A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of ¹H-NMR, ¹³C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.
authors.affiliation: School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, Shanxi, China.
authors.forename: Fei Lang
authors.initials: FL
authors.lastname: Zheng
authors.forename: Shu Rong
authors.initials: SR
authors.lastname: Ban
authors.forename: Xiu E
authors.initials: XE
authors.lastname: Feng
authors.forename: Cheng Xiao
authors.initials: CX
authors.lastname: Zhao
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.forename: Qing Shan
authors.initials: QS
authors.lastname: Li
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D005663:Furans; D047428:Protein Kinase Inhibitors; D011505:Protein-Tyrosine Kinases