title: One step forward: the use of transgenic zebrafish tumor model in drug screens.
abstract: The zebrafish (Danio rerio) has been an experimental model in the developmental biology and toxicology since the 1950s. In recent years, with the aid of transgenic technology, it has also gained an increasing popularity to model human diseases, including various cancers. As a feasible vertebrate model for large-scale chemical screens, the zebrafish has also given us a new option for the search of potential anticancer drugs. It is hopeful that in the near future with automation and analytical tools, drug development processes will be significantly shortened for quick and effective identification of candidate drugs.
authors.affiliation: Department of Biological Sciences, National University of Singapore, Singapore.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Huang
authors.forename: Anh Tuan
authors.initials: AT
authors.lastname: Nguyen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.forename: Alexander
authors.initials: A
authors.lastname: Emelyanov
authors.forename: Serguei
authors.initials: S
authors.lastname: Parinov
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Gong
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D055808:Drug Discovery / Q000379:methods*; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D023421:Models, Animal; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D015027:Zebrafish