title: GRIM-19 function in cancer development.
abstract: Cancer development involves multiple genetic changes, which can occur in tumor suppressor genes and lead to loss of function in a recessive manner. Recent findings have identified a novel tumor suppressor gene named GRIM-19. Similar to what has been observed for other known tumor suppressor proteins such as p53, GRIM-19 gene mutations and loss of protein expression have been observed in several tumor types. In this review, we perform a detailed description on the current understanding of GRIM-19 function in carcinogenesis.
authors.affiliation: Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal.
authors.forename: Severina
authors.initials: S
authors.lastname: Moreira
authors.forename: Marcelo
authors.initials: M
authors.lastname: Correia
authors.forename: Paula
authors.initials: P
authors.lastname: Soares
authors.forename: Valdemar
authors.initials: V
authors.lastname: Máximo
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D004579:Electron Transport; D015870:Gene Expression; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D006801:Humans; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D050796:STAT3 Transcription Factor / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16; D024101:Mitochondrial Proteins; C454127:OLFM4 protein, human; D050796:STAT3 Transcription Factor; D016179:Granulocyte Colony-Stimulating Factor; D009247:NADH, NADPH Oxidoreductases; C439057:NDUFA13 protein, human