title: Effect of somatostatin infusion on peptide YY secretion: studies in the acute and recovery phase of anorexia nervosa and in obesity.
abstract: OBJECTIVE
  Changes in many gastrointestinal peptides, including the anorexigenic peptide YY (PYY), which is produced by L cells, occur in both anorexia nervosa (AN) and obesity (OB). High PYY levels are present in AN, whereas in morbid OB fasting and postprandial PYY secretion is blunted. Somatostatin (somatotropin release-inhibiting factor (SRIF)) reportedly inhibits plasma PYY concentrations in animals and healthy humans, but the effect of a SRIF infusion on spontaneous PYY secretion in AN and OB is unknown.
  
  
  METHODS
  A total of 18 young women, seven with acute AN (A-AN), four with AN in the recovery phase (R-AN), and seven with morbid OB, were studied. All subjects underwent an infusion of SRIF (9 μg/kg i.v./h, over 60 min), with blood samples drawn before and at different time intervals after SRIF administration. Plasma PYY levels were measured at each time point.
  
  
  RESULTS
  SRIF significantly inhibited plasma PYY concentrations in R-AN and OB, without affecting PYY titers in A-AN. In OB, the inhibitory effect of SRIF also persisted at 90 min. Withdrawal of SRIF infusion in R-AN resulted in a prompt restoration of basal plasma PYY levels, whereas termination of SRIF infusion in OB was followed by a slower increase of PYY titers toward baseline levels. After infusion, PYY Δ area under the curve (ΔAUC) in R-AN was significantly higher than those in A-AN and OB patients. A significant difference in PYY ΔAUC between A-AN and OB was present.
  
  
  CONCLUSIONS
  These results suggest the existence of a hypo- and hyper-sensitivity of L cells to the inhibitory effect of SRIF in A-AN and OB respectively.
authors.affiliation: Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy. antonello.rigamonti@guest.unimi.it
authors.forename: Antonello E
authors.initials: AE
authors.lastname: Rigamonti
authors.forename: Silvano G
authors.initials: SG
authors.lastname: Cella
authors.forename: Sara M
authors.initials: SM
authors.lastname: Bonomo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mancia
authors.forename: Guido
authors.initials: G
authors.lastname: Grassi
authors.forename: Mario
authors.initials: M
authors.lastname: Perotti
authors.forename: Fiorenza
authors.initials: F
authors.lastname: Agosti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sartorio
authors.forename: Eugenio E
authors.initials: EE
authors.lastname: Müller
authors.forename: Angela I
authors.initials: AI
authors.lastname: Pincelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D009767:Obesity, Morbid / Q000503:physiopathology*; D019894:Peptide YY / Q000097:blood / Q000378:metabolism*; D019518:Postprandial Period; D013004:Somatostatin
chemical_list: D019894:Peptide YY; D013004:Somatostatin