title: [Granular corneal dystrophy treated with deep anterior lamellar keratoplasty: comparing histological analysis and optical coherence tomography].
abstract: Granular corneal dystrophy is a rare autosomal dominant disease. It is characterized by breadcrumb-like granular opacities in the central corneal stroma. The mutation has been localized in the TGFβI gene, which codes for keratoepithelin, an adhesion protein found in corneal epithelium and stroma. We report the case of granular corneal dystrophy in a 60-year-old man complaining of reduced visual acuity. Slit-lamp examination revealed multiple opacities in the central stroma of his left eye, and recurrent deposits in his other eye 13 years after penetrating keratoplasty. An anterior segment optical coherence tomography (Visante(®) OCT) was used to determine the location of deposits, then a deep anterior lamellar keratoplasty was performed in his left eye. The depth of the deposits revealed by Visante(®) OCT correlated well with the postsurgical histological findings. Visante(®) OCT can therefore help choose between phototherapeutic keratectomy and lamellar keratoplasty, techniques that are less invasive than penetrating keratoplasty, which is advantageous since this dystrophy is known to recur after surgery.
authors.affiliation: Service d'Ophtalmologie, CHU Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux, France. francecombillet@hotmail.fr
authors.forename: F
authors.initials: F
authors.lastname: Combillet
authors.forename: D
authors.initials: D
authors.lastname: Touboul
authors.forename: F
authors.initials: F
authors.lastname: Leger
authors.forename: J
authors.initials: J
authors.lastname: Colin
mesh_terms: D003315:Cornea / Q000473:pathology*; D003317:Corneal Dystrophies, Hereditary / Q000601:surgery*; D016039:Corneal Transplantation / Q000379:methods*; D006652:Histological Techniques; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence / Q000379:methods