title: Design and development of paclitaxel-loaded bovine serum albumin nanoparticles for brain targeting.
abstract: Bovine serum albumin (BSA) nanoparticles loaded with paclitaxel (PTX) were prepared using a desolvation technique. A 32 full factorial design (FFD) was employed to formulate nanoparticles. Nanoparticles were characterized for particle size by photon correlation spectroscopy and surface morphology by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Encapsulation efficiency, zeta potential and particle yield were also determined. Response surface linear modelling (RSLM) was used to predict the optimal formulation. Various models were applied to determine the release mechanism from PTX nanoparticles. The effect of drug-polymer ratio on the release profile of formulations was observed and was applied to determine the suitability of the predicted optimal formulation. A preliminary study to determine the feasibility of targeting the prepared nanoparticles to brain was also carried out using mice as in vivo models.
authors.affiliation: UGC-Centre for Advanced Studies, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Bansal
authors.forename: Deepak N
authors.initials: DN
authors.lastname: Kapoor
authors.forename: Rishi
authors.initials: R
authors.lastname: Kapil
authors.forename: Neha
authors.initials: N
authors.lastname: Chhabra
authors.forename: Sanju
authors.initials: S
authors.lastname: Dhawan
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000188:drug therapy; D004337:Drug Carriers / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D004339:Drug Compounding; D016503:Drug Delivery Systems; D007700:Kinetics; D008297:Male; D051379:Mice; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017239:Paclitaxel / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D014018:Tissue Distribution; D050257:Tubulin Modulators / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D050257:Tubulin Modulators; D012710:Serum Albumin, Bovine; D017239:Paclitaxel