title: [New perspectives for radiosensitization in pancreatic carcinoma: a review of mechanisms involved in pancreatic tumorigenesis].
abstract: Pancreatic carcinoma is the fifth leading cause of cancer-related mortality. The 5-year overall survival is less than 5 %. This very poor prognosis can be explained both by late diagnosis and by treatment resistance, including resistance to radiation therapy. A better understanding of the pancreatic tumorigenesis and knowledge of the most frequent mutations in pancreatic adenocarcinoma (KRAS, p16, TP53, Smad4) open new perspectives for the development of more effective treatments. This review presents the major genetic and molecular alterations in pancreatic cancer that could be targeted to improve radiosensitization.
authors.affiliation: Service d'oncologie-radiothérapie, hôpital Tenon, Assistance publique-Hôpitaux de Paris, 4 rue de la Chine, Paris, France. florence.huguet@tnn.aphp.fr
authors.forename: F
authors.initials: F
authors.lastname: Huguet
authors.forename: M
authors.initials: M
authors.lastname: Fernet
authors.forename: L
authors.initials: L
authors.lastname: Monnier
authors.forename: E
authors.initials: E
authors.lastname: Touboul
authors.forename: V
authors.initials: V
authors.lastname: Favaudon
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics / Q000627:therapeutic use; D002278:Carcinoma in Situ / Q000235:genetics / Q000473:pathology; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D018291:Cystadenoma, Mucinous / Q000473:pathology; D057210:Delayed Diagnosis; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000627:therapeutic use; D018450:Disease Progression; D016147:Genes, Tumor Suppressor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D009154:Mutation; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D009857:Oncogenes; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D011230:Precancerous Conditions / Q000473:pathology; D011836:Radiation Tolerance; D015398:Signal Transduction / Q000235:genetics; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D036341:Intercellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D003841:Deoxycytidine; D000093542:Gemcitabine