title: [The influence of combined application of quercetin and indralin on post-irradiation repair of hematopoiesis in acute radiation injury].
abstract: Experiments on mice-hybrids F1(CBA x C57B1/6) have detected a favorable effect of the associated application of quercetin (30-60 minutes before y-exposure of an animal) and a radioprotectant of urgent action indralin (in the case of its application after y-exposure) on a post-irradiation repair of the hematopoietic tissue in acute radiation sickness after y-exposure at a non-lethal dose of 6.7 Gy, which manifested itself in the accelerated formation of endogenous spleen colonies and spleen mass recovery, as well as in the lesser degree of leukopenia on the 12th and the 16th day after acute radiation injury. Quercetin per se did not have a radio-protective effect.
authors.forename: M V
authors.initials: MV
authors.lastname: Vasin
authors.forename: I B
authors.initials: IB
authors.lastname: Ushakov
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Kovtun
authors.forename: S N
authors.initials: SN
authors.lastname: Komarova
authors.forename: L A
authors.initials: LA
authors.lastname: Semenova
authors.forename: L V
authors.initials: LV
authors.lastname: Koroleva
authors.forename: A A
authors.initials: AA
authors.lastname: Galkin
authors.forename: R V
authors.initials: RV
authors.lastname: Afanas'ev
mesh_terms: D000208:Acute Disease; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051379:Mice; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use*; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000097:blood*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D013154:Spleen / Q000528:radiation effects
chemical_list: D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin; D011794:Quercetin