title: Interactions between obesity, parental history of hypertension, and age on prevalent hypertension: the People's Republic of China Study.
abstract: Age, family history, and body mass index (BMI) influence the prevalence of hypertension, but very little is known about the interplay of these factors in Chinese populations. The authors examined this issue in Chinese adults (n = 4104) in the People's Republic of China Study. In young adults (24-39 years), the prevalence of hypertension/1000 persons (95% confidence interval [CI]) at the referent BMI was greater among subjects with a parental history of hypertension (35; 15-54) compared with those without (7; 3-11). Among middle-aged (40-71 years) adults, the prevalence of hypertension was similar regardless of parental history; however, the effect of BMI was modified by parental history status. For example, at BMI = 25 kg/m(2), the prevalence difference/1000 persons was 375 (95% CI = 245-506) and 97 (95% CI = 51-144) among subjects with and without a parental history, respectively. These large differences call for further investigation of the genetic and environmental factors that could be driving this interaction.
authors.affiliation: University of North Carolina at Chapel Hill, Chapel Hill, NC 08876, USA. EvaKatz@gmail.com
authors.forename: Eva G
authors.initials: EG
authors.lastname: Katz
authors.forename: June
authors.initials: J
authors.lastname: Stevens
authors.forename: Kimberly P
authors.initials: KP
authors.lastname: Truesdale
authors.forename: Jianwen
authors.initials: J
authors.lastname: Cai
authors.forename: Kari E
authors.initials: KE
authors.lastname: North
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology*; D010290:Parents; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult