title: Why RIDL is not SIT.
abstract: History teaches that sterile insect technique (SIT) is a feasible strategy for mosquito population suppression. Female killing (FK) technologies developed later theoretically had greater potential than SIT, but depended upon chromosomal translocations. Unfortunately these were genetically unstable. New transgenic strategies have been misinterpreted as a replacement for SIT. Instead these strategies provide a means to revisit FK. Conditional lethal mutations inserted into mosquito genomes allow for adjustment of the age of mortality, female-specific lethality, bisexual lethality and manipulation of germline-specific gene expression. A recent Aedes aegypti case study demonstrates the viability of one of these new transgenic strategies.
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, USA. wcb4@lamar.colostate.edu
authors.forename: William C
authors.initials: WC
authors.lastname: Black
authors.forename: Luke
authors.initials: L
authors.lastname: Alphey
authors.forename: Anthony A
authors.initials: AA
authors.lastname: James
mesh_terms: D000483:Alleles; D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics / Q000254:growth & development; D009033:Culicidae / Q000235:genetics* / Q000254:growth & development; D005260:Female; D018014:Gene Transfer Techniques; D005799:Genes, Dominant; D005804:Genes, Lethal; D005838:Genotype; D007246:Infertility / Q000235:genetics; D008297:Male; D009032:Mosquito Control / Q000379:methods*; D016254:Mutagenesis, Insertional; D014178:Translocation, Genetic