title: Evolution: On a bender--BARs, ESCRTs, COPs, and finally getting your coat.
abstract: Tremendous variety in form and function is displayed among the intracellular membrane systems of different eukaryotes. Until recently, few clues existed as to how these internal membrane systems had originated and diversified. However, proteomic, structural, and comparative genomics studies together have revealed extensive similarities among many of the protein complexes used in controlling the morphology and trafficking of intracellular membranes. These new insights have had a profound impact on our understanding of the evolutionary origins of the internal architecture of the eukaryotic cell.
authors.affiliation: Department of Pathology, University of Cambridge, Cambridge CB2 1QT, England, UK. mcf34@cam.ac.uk
authors.forename: Mark C
authors.initials: MC
authors.lastname: Field
authors.forename: Andrej
authors.initials: A
authors.lastname: Sali
authors.forename: Michael P
authors.initials: MP
authors.lastname: Rout
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001692:Biological Transport / Q000502:physiology; D020755:Coat Protein Complex I / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D056827:Endosomal Sorting Complexes Required for Transport / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D007425:Intracellular Membranes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D020755:Coat Protein Complex I; D056827:Endosomal Sorting Complexes Required for Transport