title: Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.
abstract: Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.
authors.affiliation: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States.
authors.forename: Liying
authors.initials: L
authors.lastname: Wang
authors.forename: Sudjit
authors.initials: S
authors.lastname: Luanpitpong
authors.forename: Vincent
authors.initials: V
authors.lastname: Castranova
authors.forename: William
authors.initials: W
authors.lastname: Tse
authors.forename: Yongju
authors.initials: Y
authors.lastname: Lu
authors.forename: Varisa
authors.initials: V
authors.lastname: Pongrakhananon
authors.forename: Yon
authors.initials: Y
authors.lastname: Rojanasakul
mesh_terms: D000818:Animals; D017209:Apoptosis; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D036103:Nanotechnology; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D037742:Nanotubes, Carbon; D016159:Tumor Suppressor Protein p53