title: Y-P30 confers neuroprotection after optic nerve crush in adult rats.
abstract: The survival-promoting peptide, Y-P30, has been shown to be neuroprotective and stimulates neurite outgrowth in vitro. In this study, we examined whether the peptide increases survival and induces axon outgrowth of retinal ganglion cells after an incomplete optic nerve crush. A single intraocular injection of the peptide directly after optic nerve crush increased the number of retinal ganglion cells that preserved an axonal connection with the superior colliculus in the adult rat by more than 50%. However, administration of Y-P30 into the vitreous or optic nerve had no effect on the number of axons growing into the crush site after optic nerve crush. These findings suggest that the peptide is a neuroprotective agent after optic nerve damage, but does not stimulate the axon outgrowth.
authors.affiliation: PG Neuroplasticity, Leibniz-Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Tamar
authors.initials: T
authors.lastname: Macharadze
authors.forename: Peter
authors.initials: P
authors.lastname: Landgraf
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Pape
authors.forename: Petra
authors.initials: P
authors.lastname: Wahle
authors.forename: Michael R
authors.initials: MR
authors.lastname: Kreutz
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects; D002452:Cell Count; D004396:Coloring Agents; D056965:Injections, Intraocular; D008297:Male; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D020221:Optic Nerve Injuries / Q000188:drug therapy* / Q000473:pathology; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012165:Retinal Ganglion Cells / Q000187:drug effects; D012413:Rubidium; D015032:Zinc
chemical_list: D004396:Coloring Agents; D018696:Neuroprotective Agents; C523779:PHI-5 formulation; D010455:Peptides; C442243:dermcidin; D015032:Zinc; D012413:Rubidium