title: A rapid and convergent synthesis of the integrastatin core.
abstract: The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds.
authors.affiliation: The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, California Institute of Technology, Division of Chemistry and Chemical Engineering, Mail Code 101-20, Pasadena, CA 91125, USA.
authors.forename: Pamela M
authors.initials: PM
authors.lastname: Tadross
authors.forename: Pradeep
authors.initials: P
authors.lastname: Bugga
authors.forename: Brian M
authors.initials: BM
authors.lastname: Stoltz
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D006572:Heterocyclic Compounds, Bridged-Ring; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013997:Time Factors
chemical_list: D006575:Heterocyclic Compounds, 3-Ring; D006572:Heterocyclic Compounds, Bridged-Ring; C562141:integrastatin A; C562142:integrastatin B; D010165:Palladium