title: Lack of association of common polymorphism of LRP1 gene with myocardial infarction in a Chinese Han population.
abstract: This study examined the association of a common polymorphic allele (25G) of the low-density lipoprotein receptor-related protein1 (LRP1) gene with myocardial infarction (MI). The genotypes of LRP1 25CG (rs35282763) were determined in 347 MI patients and 347 age- and sex-frequency-matched controls from an unrelated Chinese Han population. Factor VIII (FVIII) levels were measured in the MI patients and controls by chromogenic assay and enzyme-linked immunosorbent assay (ELISA). The results showed that LRP1 25CG (rs35282763) genotype distribution did not differ significantly between patients (n=206 for 25CC, n=122 for 25CG) and controls (n=191 for 25CC, n=126 for 25CG; P>0.05). The 25G allele was not associated with a reduced risk of MI (P>0.05). Further stratifications for age, sex, and other cardiovascular risk factors did not affect the negative findings. It was concluded that the presence of the G allele at the 25CG (rs35282763) polymorphism of the LRP1 is not associated with a reduced risk of MI, and genotyping for LRP1 25CG (rs35282763) polymorphism is not useful in assessing the individual risk of MI.
authors.affiliation: Institute of Hematology and the Ministry of Education Key Lab of Targeted Biotherapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Honggang
authors.initials: H
authors.lastname: Ren
authors.affiliation: Institute of Hematology and the Ministry of Education Key Lab of Targeted Biotherapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.affiliation: Institute of Hematology and the Ministry of Education Key Lab of Targeted Biotherapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Huafang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Institute of Hematology and the Ministry of Education Key Lab of Targeted Biotherapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Sun
authors.affiliation: Institute of Hematology and the Ministry of Education Key Lab of Targeted Biotherapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Hematology and the Ministry of Education Key Lab of Targeted Biotherapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Mei
authors.affiliation: Institute of Hematology and the Ministry of Education Key Lab of Targeted Biotherapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. dr_huyu@126.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005176:Factor XIII / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C475476:LRP1 protein, human; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D005176:Factor XIII