title: Effect of crystallisation conditions and feedstock morphology on the aerosolization performance of micronised salbutamol sulphate.
abstract: Salbutamol sulphate (SS) used in dry powder inhalers requires drug particles in the respirable size range of 1-5 μm to achieve a suitable therapeutic effect. The aim of this study was therefore to determine strategies for controlling drug substance characteristics pre and post-crystallisation to facilitate the production of micronised SS with desirable particle attributes for optimal delivery as an inhaled aerosol. SS batches were crystallised using an antisolvent method to produce a range of crystal morphologies. Air jet milling was then used to reduce the size of crystallised SS particles. Starting materials and micronised batches of SS were characterised in the solid state using a range of techniques with subsequent assessment of aerosol properties. Assessment of the aerodynamic characteristics of micronised SS delivered by DPI (without any carrier) indicated that fine particle fraction and emitted dose as a percentage of the total recovered dose were dependent on the quality attributes of the micronised SS, which were directly linked to the degree of imperfections and the morphology of the crystalline feedstock used in micronisation. Aerosolization performance of micronised SS can be optimised by manipulation of feedstock characteristics through crystal engineering and through definition of optimal processing conditions for micronisation.
authors.affiliation: School of Life Sciences, University of Bradford, BD7 1DP, UK. m.h.shariare@bradford.ac.uk
authors.forename: M H
authors.initials: MH
authors.lastname: Shariare
authors.forename: M
authors.initials: M
authors.lastname: de Matas
authors.forename: P
authors.initials: P
authors.lastname: York
mesh_terms: D000280:Administration, Inhalation; D000420:Albuterol / Q000008:administration & dosage* / Q000737:chemistry*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002849:Chromatography, Gas; D003460:Crystallization; D004339:Drug Compounding / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D010316:Particle Size; D033362:Powder Diffraction; D013056:Spectrophotometry, Ultraviolet; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D001993:Bronchodilator Agents; D000420:Albuterol