title: Laboratory markers of perinatal acidosis are poor predictors of neurodevelopmental impairment in very low birth weight infants.
abstract: BACKGROUND
  In asphyxiated term and near-term infants, therapeutic hypothermia increases survival without neurologic morbidity, and extending this new treatment to preterm infants is being debated.
  
  
  OBJECTIVE
  To investigate the association of low pH and base excess (BE) at birth or admission, as used as entry criteria in cooling trials, and evolving brain damage in preterm infants.
  
  
  METHODS
  Rates of death and neurodevelopmental impairment at 12 and 20 months corrected age were assessed in a cohort of 1137 preterm infants with a gestational age <35 weeks and birth weight <1500 g in relation to severe perinatal acidosis (umbilical artery pH≤7.0, pH at admission ≤7.0, BE at admission ≤-16 mmol/l, lowest BE during first 12 h of life ≤-16 mmol/l).
  
  
  RESULTS
  Umbilical artery pH was not linked to death or neurodevelopmental impairment. There was only weak predictive power of pH or BE at admission for death (positive predictive values [PPV] 0.36/0.30, receiver operator characteristics [ROC] areas 0.591/0.701), and lowest 12-h BE for death or neurodevelopmental impairment at 12 or 20 months (PPV 0.29/0.30/0.27, ROC 0.720/0.656/0.658).
  
  
  CONCLUSIONS
  In very preterm infants, there is little association between laboratory markers of severe perinatal acidosis and neurodevelopmental outcome at 12 or 20 months.
authors.affiliation: Dept of Neonatology, Charité University Medical Center, Berlin, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Hüseman
authors.forename: Boris
authors.initials: B
authors.lastname: Metze
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Walch
authors.forename: Christoph
authors.initials: C
authors.lastname: Bührer
mesh_terms: D000138:Acidosis / Q000097:blood* / Q000150:complications* / Q000401:mortality; D001238:Asphyxia Neonatorum / Q000150:complications; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000097:blood / Q000209:etiology*; D005865:Gestational Age; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood* / Q000401:mortality; D019102:Infant, Very Low Birth Weight / Q000097:blood / Q000254:growth & development*; D012372:ROC Curve; D014469:Umbilical Arteries
chemical_list: D015415:Biomarkers