title: GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism.
abstract: OBJECTIVE
  We explored association between GSTP1 Ile(105)Val (rs1695) polymorphism and GSTP1 mRNA expression in circulating blood leukocytes.
  
  
  METHODS
  GSTP1 transcripts level and polymorphism were determined by Real-Time PCR in 51 bladder cancer and 90 healthy men.
  
  
  RESULTS
  Individuals with at least one GSTP1 Val(105) variant allele possessed higher GSTP1 mRNA level in blood leukocytes compared to GSTP1 Ile(105)Ile carriers.
  
  
  CONCLUSIONS
  GSTP1 Ile(105)Val gene polymorphism influences its expression in blood, regardless of cancer disease.
authors.affiliation: Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland. Electronic address: edyta@imp.lodz.pl.
authors.forename: Edyta
authors.initials: E
authors.lastname: Reszka
authors.affiliation: I Department of Urology, Medical University, Lodz, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Jabłonowski
authors.affiliation: Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Wieczorek
authors.affiliation: Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Gromadzińska
authors.affiliation: I Department of Urology, Medical University, Lodz, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Sosnowski
authors.affiliation: Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wąsowicz
mesh_terms: D000368:Aged; D001773:Blood Cells; D016022:Case-Control Studies; D015870:Gene Expression; D051549:Glutathione S-Transferase pi / Q000097:blood* / Q000235:genetics*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000032:analysis*; D001749:Urinary Bladder Neoplasms
chemical_list: D012333:RNA, Messenger; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi