title: Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.
abstract: In April 2010, a NIH workshop was convened to discuss the current state of understanding of lung cell plasticity, including the responses of epithelial cells to injury, with the objectives of summarizing what is known, what the field needs to know, and how to get there. The proximal stimulus for this workshop is the body of recent evidence suggesting that plasticity is a prominent but incompletely characterized property of lung epithelial cells, and that a focus on understanding this aspect of epithelial cell biology in particular, may be an important window into disease pathobiology and pathogenesis. In addition to their many vital functions in maintaining tissue homeostasis, epithelial cells have emerged as both a central target of disease initiation and an active contributor to disease progression, making a workshop to investigate the role of cell plasticity in lung injury and repair timely. The workshop was organized around four major themes: lung epithelial cell plasticity, signaling control of plasticity, fibroblast plasticity and crosstalk, and translation to human disease. Although this breakdown was recognized to be somewhat artificial, it was felt that this approach would promote cross-fertilization among groups that ordinarily do not communicate and lend itself to the generation of new approaches. The summary reports of individual group discussions below are followed by consensus priorities and recommendations of the workshop participants.
authors.affiliation: University of Southern California, Los Angeles, California, USA.
authors.forename: Zea
authors.initials: Z
authors.lastname: Borok
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Whitsett
authors.forename: Peter B
authors.initials: PB
authors.lastname: Bitterman
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Thannickal
authors.forename: Darrell N
authors.initials: DN
authors.lastname: Kotton
authors.forename: Susan D
authors.initials: SD
authors.lastname: Reynolds
authors.forename: Mark A
authors.initials: MA
authors.lastname: Krasnow
authors.forename: Diana W
authors.initials: DW
authors.lastname: Bianchi
authors.forename: Edward E
authors.initials: EE
authors.lastname: Morrisey
authors.forename: Brigid L
authors.initials: BL
authors.lastname: Hogan
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Kurie
authors.forename: David C
authors.initials: DC
authors.lastname: Walker
authors.forename: Derek C
authors.initials: DC
authors.lastname: Radisky
authors.forename: Steve L
authors.initials: SL
authors.lastname: Nishimura
authors.forename: Shelia M
authors.initials: SM
authors.lastname: Violette
authors.forename: Paul W
authors.initials: PW
authors.lastname: Noble
authors.forename: Steve D
authors.initials: SD
authors.lastname: Shapiro
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Blaisdell
authors.forename: Harold A
authors.initials: HA
authors.lastname: Chapman
authors.forename: James
authors.initials: J
authors.lastname: Kiley
authors.forename: Dorothy
authors.initials: D
authors.lastname: Gail
authors.forename: Deborah
authors.initials: D
authors.lastname: Hoshizaki
mesh_terms: D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation; D019070:Cell Lineage; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D004847:Epithelial Cells / Q000473:pathology*; D005347:Fibroblasts / Q000502:physiology; D005786:Gene Expression Regulation; D005819:Genetic Markers; D006801:Humans; D008168:Lung / Q000166:cytology / Q000196:embryology; D008171:Lung Diseases / Q000473:pathology* / Q000503:physiopathology; D008853:Microscopy; D014411:Neoplastic Stem Cells; D057285:Precision Medicine; D011650:Pulmonary Alveoli / Q000166:cytology; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D051153:Wnt Proteins