title: A new cytotoxic coumarin, 7-[(E)-3',7'-dimethyl-6'-oxo-2',7'-octadienyl] oxy coumarin, from the leaves of Zanthoxylum schinifolium.
abstract: A new coumarin, 7-[(E)-3',7'-dimethyl-6'-oxo-2',7'-octadienyl]oxy coumarin (1), together with three known compounds, schinilenol (2), schinindiol (3) and 7-[(E)-7'-hydroxy-3',7'-dimethylocta-2',5'-dienyloxy]-coumarin (4) were isolated from the methylene chloride fraction of Z. schinifolium by normal and reverse phase column chromatographies. Their structures were determined on the basis of physical and spectroscopic evidences. Compound 1 (IC(50) 8.10 μM) showed potent cytotoxicity compared to auraptene (IC(50) 55.36 μM) against Jurkat T cells. The other isolated compounds 2 and 4 exhibited weak cytotoxicities.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Korea.
authors.forename: Bo Kyung
authors.initials: BK
authors.lastname: Min
authors.forename: Dong Geol
authors.initials: DG
authors.lastname: Hyun
authors.forename: Su Yang
authors.initials: SY
authors.lastname: Jeong
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Ma
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D020128:Inhibitory Concentration 50; D007536:Isomerism; D019169:Jurkat Cells; D015458:Leukemia, T-Cell / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008752:Methylene Chloride / Q000737:chemistry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D056910:Republic of Korea; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: C561630:7-(3',7'-dimethyl-6'-oxo-2',7'-octadienyl)oxycoumarin; D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D010936:Plant Extracts; D012997:Solvents; D008752:Methylene Chloride