title: Transplantation tolerance: memories that haunt us.
abstract: Transplant tolerance, which allows grafts--allogeneic cells, tissues, or organs--to be accepted without host immunosuppression, can be achieved in mice but not in primates. In this issue of Science Translational Medicine, Nadazdin et al. report that a high pretransplant frequency of graft-reactive memory T cells may inhibit the induction of transplant tolerance in nonhuman primates and lead to transplant rejection. Knowing the frequency of allograft-specific memory T cells in potential transplant recipients could aid clinical decision-making by guiding selection of the antigenic profile of the donor organ or by influencing the type of tolerance-induction protocol pursued.
authors.affiliation: Emory Transplant Center, Atlanta, GA 30322, USA.
authors.forename: Mandy L
authors.initials: ML
authors.lastname: Ford
authors.forename: Christian P
authors.initials: CP
authors.lastname: Larsen
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology*; D005434:Flow Cytometry; D006085:Graft Survival / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology*; D008252:Macaca fascicularis; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*