title: Does adiponectin benefit steatotic liver transplantation?
abstract: Strategies for improving the viability of steatotic donor livers could increase the number of organs suitable for transplantation. There is evidence that adiponectin, the most abundant adipose-specific adipokine, acts as an anti-obesity and anti-inflammatory hormone. Here we review the signaling pathways of adiponectin and the possible therapies based on adiponectin regulation that have been examined or applied clinically. Recent studies on the role of adiponectin in steatotic livers subjected to ischemia/reperfusion are discussed. The data suggest that further investigations are required to determine whether adiponectin is a potential therapeutic target in liver transplantation.
authors.affiliation: Esther Koplowitz Center, August Pi i Sunyer Institute for Biomedical Research, Barcelona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Elias-Miro
authors.forename: Marta
authors.initials: M
authors.lastname: Massip-Salcedo
authors.forename: Monica
authors.initials: M
authors.lastname: Jimenez-Castro
authors.forename: Carmen
authors.initials: C
authors.lastname: Peralta
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D005234:Fatty Liver / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007511:Ischemia; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation / Q000379:methods*; D051379:Mice; D008953:Models, Anatomic; D009765:Obesity / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker; D015427:Reperfusion Injury / Q000473:pathology; D015398:Signal Transduction; D009927:Tissue and Organ Procurement
chemical_list: D052242:Adiponectin