title: Progress in molecular typing of Mycobacterium avium subspecies paratuberculosis.
abstract: Mycobacterium avium subspecies paratuberculosis (M. a. paratuberculosis) is responsible for paratuberculosis or Johne's disease, a chronic inflammation of the gastrointestinal tract in different animal species. Some studies have also established a link between this microorganism and Crohn's disease in humans. Although, M. a. paratuberculosis is a difficult microorganism to cultivate in the laboratory (occasionally is non-cultivable), a proper molecular characterization of M. a. paratuberculosis is necessary to better understand the epidemiology of the disease, and design strategies to eradicate it. In the present review, we compile and discuss the recent progress attained in the diagnostic and characterization of this pathogen.
authors.affiliation: Departamento de Sanidad Animal, Faculty of Veterinary Sciences, Universidad Complutense de Madrid, Avenida Puerta de Hierro, s/n 28040 Madrid, Spain. Elena_CastellanosRizaldos@dfci.harvard.edu
authors.forename: Elena
authors.initials: E
authors.lastname: Castellanos
authors.forename: Lucía
authors.initials: L
authors.lastname: de Juan
authors.forename: Lucas
authors.initials: L
authors.lastname: Domínguez
authors.forename: Alicia
authors.initials: A
authors.lastname: Aranaz
mesh_terms: D000818:Animals; D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D058889:Molecular Typing / Q000379:methods; D016927:Mycobacterium avium subsp. paratuberculosis / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010283:Paratuberculosis / Q000175:diagnosis / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial