title: Ganglioglioma arising from dysplastic cortex.
abstract: We report the case of a child who presented at 3 months of age with complex partial seizures, a linear facial nevus, and magnetic resonance imaging (MRI) showing delayed myelination and thickened cortex in the left temporal, parietal, and occipital regions. A repeat 3Tesla MRI scan with and without contrast at 6 months again showed cortical dysplasia of the left hemisphere. No other abnormalities were seen. A third scan at 3 years 6 months showed a 2.5 cm, round, hyperintense lesion on both T(2) and T(1) sequences. The lesion and surrounding dysplastic cortex were resected. Palmini grade IIA dysplasia and a ganglioglioma were diagnosed. These findings suggest that cellular components of cortical dysplasias have oncogenic potential.
authors.affiliation: Department of Pediatrics and Neurology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. ortizgonzalez@email.chop.edu
authors.forename: Xilma R
authors.initials: XR
authors.lastname: Ortiz-González
authors.forename: Sriram
authors.initials: S
authors.lastname: Venneti
authors.forename: Jaclyn A
authors.initials: JA
authors.lastname: Biegel
authors.forename: Lucy B
authors.initials: LB
authors.lastname: Rorke-Adams
authors.forename: Brenda E
authors.initials: BE
authors.lastname: Porter
mesh_terms: D001932:Brain Neoplasms / Q000209:etiology*; D005260:Female; D018303:Ganglioglioma / Q000209:etiology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D054220:Malformations of Cortical Development / Q000150:complications* / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D010751:Phosphopyruvate Hydratase