title: [Study on dispersivity of baicalin solid dispersion by vibrational spectrometry].
abstract: OBJECTIVE
  To study the dispersivity of baicalin solid dispersion by Raman spectrometry and infrared spectrometry in order to obtain a new and simple method in examining the dispersivity of solid dispersion.
  
  
  METHODS
  Baicalin solid dispersion was prepared by solvent method. The Raman spectra, infrared spectra and X-ray powder diffraction patterns of crude baicalin, PVP K30, physical mixture, solid dispersion were acquired by Raman and Fourier transform infrared spectrometers and X-ray powder diffractometry. Then the spectra were compared with each other in order to find out the differences between baicalin solid dispersion and other materials.
  
  
  RESULTS
  The result of Raman spectrometry was that amorphous baicalin presented in the solid dispersion, which was in agreement with that of X-ray powder diffractometry.
  
  
  CONCLUSIONS
  Raman spectrometry which is fast, direct and non-destructive is an ideal method for examining the dispersivity of solid dispersion.
authors.affiliation: Pharmaceutical College of Henan University, Kaifeng 475004, China. wayne770@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaoman
authors.initials: X
authors.lastname: Li
authors.forename: Jinghui
authors.initials: J
authors.lastname: Tian
authors.forename: Xinxin
authors.initials: X
authors.lastname: Xi
authors.forename: Li
authors.initials: L
authors.lastname: Cheng
mesh_terms: D005419:Flavonoids / Q000737:chemistry*; D012995:Solubility; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman; D014961:X-Ray Diffraction
chemical_list: D005419:Flavonoids; D012997:Solvents; C038044:baicalin