title: Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitus.
abstract: BACKGROUND
  Two SNPs in melatonin receptor 1B gene, rs10830963 and rs1387153 showed significant associations with fasting plasma glucose levels and the risk of Type 2 Diabetes Mellitus (T2DM) in previous studies. Since T2DM and gestational diabetes mellitus (GDM) share similar characteristics, we suspected that the two genetic polymorphisms in MTNR1B may be associated with GDM, and conducted association studies between the polymorphisms and the disease. Furthermore, we also examined genetic effects of the two polymorphisms with various diabetes-related phenotypes.
  
  
  METHODS
  A total of 1,918 subjects (928 GDM patients and 990 controls) were used for the study. Two MTNR1B polymorphisms were genotyped using TaqMan assay. The allele distributions of SNPs were evaluated by x2 models calculating odds ratios (ORs), 95% confidence intervals (CIs), and corresponding P values. Multiple regressions were used for association analyses of GDM-related traits. Finally, conditional analyses were also performed.
  
  
  RESULTS
  We found significant associations between the two genetic variants and GDM, rs10830963, with a corrected P value of 0.0001, and rs1387153, with the corrected P value of 0.0008. In addition, we also found that the two SNPs were associated with various phenotypes such as homeostasis model assessment of beta-cell function and fasting glucose levels. Further conditional analyses results suggested that rs10830963 might be more likely functional in case/control analysis, although not clear in GDM-related phenotype analyses.
  
  
  CONCLUSIONS
  There have been studies that found associations between genetic variants of other genes and GDM, this is the first study that found significant associations between SNPs of MTNR1B and GDM. The genetic effects of two SNPs identified in this study would be helpful in understanding the insight of GDM and other diabetes-related disorders.
authors.affiliation: Department of Life Science, Sogang University, Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, 1 Shinsu-dong, Mapo-gu, Seoul, 121-742, Republic of Korea.
authors.forename: Jason Y
authors.initials: JY
authors.lastname: Kim
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Byung-Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Sei Hyun
authors.initials: SH
authors.lastname: Baik
authors.forename: Sunmin
authors.initials: S
authors.lastname: Park
authors.forename: Si Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Min-Hyoung
authors.initials: MH
authors.lastname: Kim
authors.forename: Jin Hoon
authors.initials: JH
authors.lastname: Chung
authors.forename: June Seek
authors.initials: JS
authors.lastname: Choi
authors.forename: Moon-Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Jae-Hyug
authors.initials: JH
authors.lastname: Yang
authors.forename: Dong-Hee
authors.initials: DH
authors.lastname: Cho
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000235:genetics; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000097:blood / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000097:blood; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D044123:Receptor, Melatonin, MT2 / Q000235:genetics*; D012306:Risk; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D044123:Receptor, Melatonin, MT2