title: Nosocomial MRSA pneumonia: data from recent clinical trials.
abstract: MRSA infections, especially pneumonia have been associated with considerable morbidity and mortality and the management of MRSA infections is considered as an issue of high priority for scientific societies. Many studies which have been published during the last 10 years have provided evidence for MRSA pneumonia epidemiology, diagnosis and treatment. The main regime of antibiotic treatment recommended for MRSA pneumonia is either vancomycin or linezolid. Despite its pK/pD superiority over vancomycin, linezolid has to date failed to show clear advantage over vancomycin in recent clinical trials.
authors.affiliation: Intensive Care Unit, University Hospital of Larissa, Larissa, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Karvouniaris
authors.forename: D
authors.initials: D
authors.lastname: Makris
authors.forename: D
authors.initials: D
authors.lastname: Karabekos
authors.forename: E
authors.initials: E
authors.lastname: Zakynthinos
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D001999:Bronchoscopy; D003428:Cross Infection / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D004269:DNA, Bacterial; D006801:Humans; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics; D023303:Oxazolidinones / Q000627:therapeutic use; D011023:Pneumonia, Staphylococcal / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D053717:Pneumonia, Ventilator-Associated / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid