title: Cell fate plug and play: direct reprogramming and induced pluripotency.
abstract: Building on the discovery that MyoD expression reprograms fibroblasts into muscle, three papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors without first passing the cells through a pluripotent state. Here we discuss the advantages and challenges of harnessing this direct reprogramming method for regenerative medicine.
authors.affiliation: Center for Stem Cell Biology, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA. chambers@mskcc.org
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Chambers
authors.forename: Lorenz
authors.initials: L
authors.lastname: Studer
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D044968:Regenerative Medicine; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors