title: Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia.
abstract: T cell chemotaxis to sphingosine 1-phosphate (S1P) and the chemokines CCL21 and CCL5 was studied in ten adults with T lymphocytopenia, other immunological abnormalities (nine of ten), and frequent bacterial infections (seven of ten). Mean chemotactic responses to S1P of CD4 T cells from CD4 T lymphocytopenic patients and of CD8 T cells from CD8 T lymphocytopenic patients were significantly lower than those of healthy matched controls. Chemotaxis to CCL21 was lower than that of controls for CD4 T cells of three CD4 T lymphocytopenic patients and for CD8 T cells of three CD8 T lymphocytopenic patients, but none of the T cells of patients had diminished chemotaxis to CCL5. Defective T cell chemotactic responses to S1P and some chemokines may lead to subset-selective abnormal T cell trafficking and chronic T cell lymphocytopenia.
authors.affiliation: Department of Medicine, University of California, Geriatric Research Center, San Francisco, CA 94112, USA. edward.goetzl@ucsf.edu
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Goetzl
authors.forename: Janice B
authors.initials: JB
authors.lastname: Schwartz
authors.forename: Mei-Chuan
authors.initials: MC
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001424:Bacterial Infections; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D054421:Chemokine CCL21 / Q000276:immunology; D018946:Chemokine CCL5 / Q000276:immunology; D002633:Chemotaxis; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008231:Lymphopenia / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D008246:Lysophospholipids / Q000276:immunology; D008297:Male; D008875:Middle Aged; D054400:Receptors, CCR7 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D049349:Receptors, Lysosphingolipid / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D012008:Recurrence; D013110:Sphingosine / Q000031:analogs & derivatives / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D001323:Autoantibodies; C515370:CCR7 protein, human; D054421:Chemokine CCL21; D018946:Chemokine CCL5; D007075:Immunoglobulin M; D008246:Lysophospholipids; D054400:Receptors, CCR7; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine