title: Sharing of quorum-sensing signals and role of interspecies communities in a bacterial plant disease.
abstract: Pathogenic bacteria interact not only with the host organism but most probably also with the resident microbial flora. In the knot disease of the olive tree (Olea europaea), the causative agent is the bacterium Pseudomonas savastanoi pv. savastanoi (Psv). Two bacterial species, namely Pantoea agglomerans and Erwinia toletana, which are not pathogenic and are olive plant epiphytes and endophytes, have been found very often to be associated with the olive knot. We identified the chemical signals that are produced by strains of the three species isolated from olive knot and found that they belong to the N-acyl-homoserine lactone family of QS signals. The luxI/R family genes responsible for the production and response to these signals in all three bacterial species have been identified and characterized. Genomic knockout mutagenesis and in planta experiments showed that virulence of Psv critically depends on QS; however, the lack of signal production can be complemented by wild-type E. toletana or P. agglomerans. It is also apparent that the disease caused by Psv is aggravated by the presence of the two other bacterial species. In this paper we discuss the potential role of QS in establishing a stable consortia leading to a poly-bacterial disease.
authors.affiliation: Dipartimento di Scienze Agrarie e Ambientali, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: Taha
authors.initials: T
authors.lastname: Hosni
authors.forename: Chiaraluce
authors.initials: C
authors.lastname: Moretti
authors.forename: Giulia
authors.initials: G
authors.lastname: Devescovi
authors.forename: Zulma Rocio
authors.initials: ZR
authors.lastname: Suarez-Moreno
authors.forename: M' Barek
authors.initials: MB
authors.lastname: Fatmi
authors.forename: Corrado
authors.initials: C
authors.lastname: Guarnaccia
authors.forename: Sandor
authors.initials: S
authors.lastname: Pongor
authors.forename: Andrea
authors.initials: A
authors.lastname: Onofri
authors.forename: Roberto
authors.initials: R
authors.lastname: Buonaurio
authors.forename: Vittorio
authors.initials: V
authors.lastname: Venturi
mesh_terms: D054742:Acyl-Butyrolactones / Q000378:metabolism; D060026:Endophytes; D004885:Erwinia / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D031658:Olea / Q000382:microbiology*; D020636:Pantoea / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D010935:Plant Diseases / Q000382:microbiology*; D011549:Pseudomonas / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism* / Q000472:pathogenicity; D053038:Quorum Sensing; D014774:Virulence; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D054742:Acyl-Butyrolactones; D037521:Virulence Factors