title: Effect of Tridax procumbens (Linn.) on bile duct ligation-induced liver fibrosis in rats.
abstract: The present study was undertaken to clarify whether methanolic extract of Tridax procumbens prevents liver fibrosis in rat. The hepatic fibrosis was induced by 28 days of bile duct ligation in rats. The 4-week treatment with Tridex procumbens reduced the serum aspartate aminotransferase (U L⁻¹), glutamate pyruvate transaminase (U L⁻¹), alkaline phosphatase (IU L⁻¹), lactate dehydrogenase (IU L⁻¹), total bilirubin (mg dL⁻¹), direct bilirubin (mg dL⁻¹) and hydroxyproline (mg gm⁻¹) content in liver and improved the histological appearance of liver section. The results of this study led us to conclude that T. procumbens can reduce the degree of hepatocellular damage and may become antifibrotic agent for liver fibrosis.
authors.affiliation: Department of Pharmacology, R.C. Patel College of Pharmacy, Shirpur, Maharastra, India.
authors.forename: P P
authors.initials: PP
authors.lastname: Joshi
authors.forename: S D
authors.initials: SD
authors.lastname: Patil
authors.forename: N
authors.initials: N
authors.lastname: Silawat
authors.forename: P T
authors.initials: PT
authors.lastname: Deshmukh
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D019659:Asteraceae / Q000737:chemistry*; D001652:Bile Ducts / Q000601:surgery; D001663:Bilirubin / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006909:Hydroxyproline / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008026:Ligation / Q000009:adverse effects; D008103:Liver Cirrhosis / Q000209:etiology / Q000517:prevention & control*; D000432:Methanol; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
chemical_list: D010936:Plant Extracts; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D001663:Bilirubin; D006909:Hydroxyproline; D000432:Methanol