title: Lyonin A, a new 9,10-Secograyanotoxin from Lyonia ovalifolia.
abstract: Phytochemical studies on the branches and leaves of Lyonia ovalifolia yielded a new grayanane diterpenoid, lyonin A (1), together with two known compounds, secorhodomollolides A and D (2 and 3, resp.). The structure of 1 was elucidated by combination of 1D- and 2D-NMR, and MS analyses. Compound 1 turned out to be a new, highly O-acylated grayanane diterpenoid, of which ring B has undergone an oxidative cleavage between C(9) and C(10), yielding a system differing from the previously reported grayanane type with a 5/7/6/5 ring system. Results of the cAMP regulation activity assay showed that compounds 2 and 3 at 50 μM induced a significantly decreased cAMP level in N1E-115 neuroblastoma cells (p<0.001), indicating neuropharmacological potential.
authors.affiliation: The College of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650224, P. R. China.
authors.forename: Zhao-Yuan
authors.initials: ZY
authors.lastname: Wu
authors.forename: Hai-Zhou
authors.initials: HZ
authors.lastname: Li
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Wang
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
mesh_terms: D045744:Cell Line, Tumor; D000242:Cyclic AMP / Q000378:metabolism; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029791:Ericaceae / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: D004224:Diterpenes; D000242:Cyclic AMP