title: sp3 C-H bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines.
abstract: A selective C(3)-alkylation via activation/functionalization of sp(3) C-H bond of saturated cyclic amines was promoted by (arene)ruthenium(II) complexes featuring a bidentate phosphino-sulfonate ligand upon reaction with aldehydes. This highly regioselective sustainable transformation takes place via initial dehydrogenation of cyclic amines and hydrogen autotransfer processes.
authors.affiliation: UMR6226 CNRS-Université de Rennes, Sciences chimiques de Rennes, Catalyse et Organométalliques, Campus de Beaulieu, 35042 Rennes Cedex, France.
authors.forename: Basker
authors.initials: B
authors.lastname: Sundararaju
authors.forename: Mathieu
authors.initials: M
authors.lastname: Achard
authors.forename: Gangavaram V M
authors.initials: GV
authors.lastname: Sharma
authors.forename: Christian
authors.initials: C
authors.lastname: Bruneau
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D008024:Ligands; D010720:Phosphines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D008024:Ligands; D010720:Phosphines; D013451:Sulfonic Acids; D002244:Carbon; D012428:Ruthenium; D006859:Hydrogen