title: In vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the Transplant-Associated Infection Surveillance Network.
abstract: We determined the echinocandin minimum effective concentration (MEC) values for caspofungin, micafungin, and anidulafungin against 288 Aspergillus isolates prospectively collected from transplant patients with proven or probable invasive aspergillosis between 2001 and 2006 as part of the Transplant-Associated Infection Surveillance Network (TRANSNET). We demonstrated that the vast majority of Aspergillus isolates had MEC values at or below the epidemiological cutoff values for caspofungin, micafungin, and anidulafungin, including those from patients who had received caspofungin.
authors.affiliation: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. gyi2@cdc.gov
authors.forename: Shawn R
authors.initials: SR
authors.lastname: Lockhart
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Zimbeck
authors.forename: John W
authors.initials: JW
authors.lastname: Baddley
authors.forename: Kieren A
authors.initials: KA
authors.lastname: Marr
authors.forename: David R
authors.initials: DR
authors.lastname: Andes
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: Carol A
authors.initials: CA
authors.lastname: Kauffman
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
authors.forename: James I
authors.initials: JI
authors.lastname: Ito
authors.forename: Peter G
authors.initials: PG
authors.lastname: Pappas
authors.forename: Tom
authors.initials: T
authors.lastname: Chiller
mesh_terms: D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology*; D001230:Aspergillus / Q000187:drug effects* / Q000302:isolation & purification; D000077336:Caspofungin; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D055666:Lipopeptides / Q000494:pharmacology*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests; D014180:Transplantation
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077612:Anidulafungin; D000077336:Caspofungin; D000077551:Micafungin