title: Efficacy of anesthetic agents to delay pain onset after periodontal surgery.
abstract: The aim of this study was to evaluate the influence of 2 anesthetic agents on patients' postoperative pain perception after periodontal surgery. For this parallel-group, double-blinded, randomized clinical trial, 36 open flap debridement surgeries were performed on patients who presented with periodontal disease with clinical signs of inflammation after nonsurgical treatment on at least 1 quadrant. Patients were allocated to 1 of the following groups: group 1, 2% lidocaine with 1 ∶ 100,000 epinephrine; group 2, 2% mepivacaine with 1 ∶ 100,000 norepinephrine. Pain intensity was assessed using the visual analog scale during the first 8 hours after surgery. All patients received 750-mg acetaminophen tablets, which they were instructed to take as a rescue medication if necessary. The results demonstrated that postoperative pain intensity was statistically lower in group 2 than in group 1 at the 1-, 2-, and 3-hour periods after surgery, although the pain intensity for all groups could be considered mild. In conclusion, patients in both groups reported similar mild pain after periodontal surgery.
authors.affiliation: University of São Paulo State, Araraquara, Brazil. joaopaulosteffens@hotmail.com
authors.forename: Joao Paulo
authors.initials: JP
authors.lastname: Steffens
authors.forename: Márcia Thaís
authors.initials: MT
authors.lastname: Pochapski
authors.forename: Fábio André
authors.initials: FA
authors.lastname: Santos
authors.forename: Gibson Luiz
authors.initials: GL
authors.lastname: Pilatti
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage*; D055113:Chronic Periodontitis / Q000601:surgery*; D003646:Debridement; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D008619:Mepivacaine / Q000008:administration & dosage; D008875:Middle Aged; D009638:Norepinephrine / Q000008:administration & dosage; D010147:Pain Measurement; D058748:Pain Perception / Q000187:drug effects*; D010149:Postoperative Pain / Q000517:prevention & control*; D018709:Statistics, Nonparametric; D014662:Vasoconstrictor Agents / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D008012:Lidocaine; D008619:Mepivacaine; D009638:Norepinephrine; D004837:Epinephrine