title: [Association between allergy to benzoyl peroxide, vitiligo and implantation of a cemented total knee joint prosthesis: Is there a connection?].
abstract: Allergies against bone cement or bone cement components have been well-described. We report on a 63-year-old patient who presented with progressive vitiligo all over the body after implantation of a cemented total knee replacement. A dermatological examination was performed and an allergy to benzoyl peroxide was found. A low-grade infection was diagnosed 5 months after implantation of the total knee replacement and the prosthesis was replaced with a cement spacer. After treating the infection of the knee replacement non-cemented arthrodesis of the knee was performed. In cases of new, unknown skin efflorescence, urticaria and periprosthetic loosening of cemented joint replacement, the differential diagnosis should include not only infections but also possible allergies against bone-cement and components such as benzoyl peroxide or metal components.
authors.affiliation: Chirurgische Klinik und Poliklinik, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Ruhr-Universität, Bürkle-de-la-Camp Platz 1, 44789, Bochum, Deutschland. mgothner@gmx.de
authors.forename: M
authors.initials: M
authors.lastname: Gothner
authors.forename: L
authors.initials: L
authors.lastname: Ozokyay
authors.forename: P
authors.initials: P
authors.lastname: Godau
authors.forename: T
authors.initials: T
authors.lastname: Kälicke
authors.forename: G
authors.initials: G
authors.lastname: Muhr
authors.forename: T A
authors.initials: TA
authors.lastname: Schildhauer
authors.forename: M
authors.initials: M
authors.lastname: Dudda
mesh_terms: D019645:Arthroplasty, Replacement, Knee; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000633:toxicity*; D001843:Bone Cements / Q000633:toxicity*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000633:toxicity*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000601:surgery*; D010328:Patch Tests; D011475:Prosthesis Failure; D012086:Reoperation; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000601:surgery; D013212:Staphylococcus epidermidis; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000601:surgery; D014820:Vitiligo / Q000139:chemically induced*
chemical_list: D001843:Bone Cements; D003879:Dermatologic Agents; D001585:Benzoyl Peroxide