title: Examining the role of cyclin D1 in breast cancer.
abstract: Cyclin D1 overexpression is found in more than 50% of human breast cancers and causes mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function contributes to the loss of normal cell cycle control during tumorigenesis. Recent studies have demonstrated that cyclin D1 conducts additional specific functions to regulate gene expression in the context of local chromatin, promote cellular migration and inhibit mitochondrial metabolism. It is anticipated that these additional functions contribute to the pathology associated with dysregulated cyclin D1 abundance. This article discusses evidence that examines the significance of cyclin D1 in breast cancer with emphasis on its role in breast cancer stem cell expansion.
authors.affiliation: Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Apdo Postal 70-297, México DF, México.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Velasco-Velázquez
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Li
authors.forename: Mathew
authors.initials: M
authors.lastname: Casimiro
authors.forename: Emanuele
authors.initials: E
authors.lastname: Loro
authors.forename: Nora
authors.initials: N
authors.lastname: Homsi
authors.forename: Richard G
authors.initials: RG
authors.lastname: Pestell
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism; D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D042361:Mammary Glands, Human / Q000201:enzymology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism
chemical_list: D020033:Protein Isoforms; D019938:Cyclin D1; D018844:Cyclin-Dependent Kinases