title: Flavonoids from the roots of Campylotropis hirtella.
abstract: Eight new flavonoids, including three pterocarpene derivatives, hirtellanines C-E, two flavanones, hirtellanines F and G, three isoflavanones, hirtellanines H-J, as well as four known compounds were isolated from the roots of Campylotropis hirtella. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D-NMR techniques. Pharmacological investigation indicated that the new compounds, particularly hirtellanines D and G, possessed potent immunosuppressive activities and low relative cytotoxicities.
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Tan
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Zhengwu
authors.initials: Z
authors.lastname: Shen
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D005419:Flavonoids; D007166:Immunosuppressive Agents; D007529:Isoflavones; D010936:Plant Extracts; C542852:hirtellanine A; C542853:hirtellanine B