title: Successful aging shows linkage to chromosomes 6, 7, and 14 in the Amish.
abstract: Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13-generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected-only 2-point and multipoint linkage analysis. Eleven SNPs produced 2-point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA.
authors.affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Digna R Velez
authors.initials: DR
authors.lastname: Edwards
authors.forename: John R
authors.initials: JR
authors.lastname: Gilbert
authors.forename: Lan
authors.initials: L
authors.lastname: Jiang
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Gallins
authors.forename: Laura
authors.initials: L
authors.lastname: Caywood
authors.forename: Marilyn
authors.initials: M
authors.lastname: Creason
authors.forename: Denise
authors.initials: D
authors.lastname: Fuzzell
authors.forename: Clare
authors.initials: C
authors.lastname: Knebusch
authors.forename: Charles E
authors.initials: CE
authors.lastname: Jackson
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Haines
authors.forename: William K
authors.initials: WK
authors.lastname: Scott
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002883:Chromosomes, Human, Pair 14; D002896:Chromosomes, Human, Pair 6; D002897:Chromosomes, Human, Pair 7; D005260:Female; D008040:Genetic Linkage; D055106:Genome-Wide Association Study; D006801:Humans; D008126:Lod Score; D008136:Longevity / Q000235:genetics*; D008297:Male; D010375:Pedigree; D010414:Pennsylvania; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups