title: Investigating maspin in breast cancer progression using mouse models.
abstract: Clade B serpin family of proteins regulate a variety of cellular functions including cell adhesion and motility. One key member of the clade B serpin family is maspin (SERPINB5). Maspin is classified as a type II tumor suppressor that regulates cell adhesion and invasion. It is expressed in normal mammary epithelial cells but is reduced in benign breast tumors and absent in invasive breast carcinomas. Although maspin regulates cell apoptosis, cell adhesion, migration, and invasion in breast cancer cell culture systems, mouse models are necessary to verify this in vivo. In this chapter, we review the development of transgenic and syngeneic mouse models to study the role of maspin in mammary tumorigenesis and in normal mammary development.
authors.affiliation: Robert H. Lurie Comprehensive Cancer Center and Center for Genetic Medicine, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Endsley
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D015843:Serpins / Q000235:genetics / Q000378:metabolism*
chemical_list: C085344:SERPIN-B5; D015843:Serpins