title: An unusual cause for sicca syndrome.
abstract: We present a case of a 47-year-old female who presented with sicca symptoms since three months. As per the Revised International Classification Criteria for Sjögren's syndrome, patient was diagnosed as primary Sjögren's syndrome (SS). Patients with SS are known to have circulating monoclonal immunoglobulins. Serum electrophoresis revealed M band with serum gamma globulin concentration of 46 g/L. Bone marrow aspiration revealed 28% plasma cells. In absence of myeloma-related organ damage, a diagnosis of smouldering myeloma (MM) was made. Patient was treated with thalidomide and dexamethasone. Sicca symptoms resolved with anti-myeloma treatment. Although MM can occur as a complication of SS, MM can also rarely present as SS. In the present case, the short duration of sicca symptoms and response of these symptoms to anti-myeloma treatment support the diagnosis of MM presenting as SS. The present case highlights the importance of serum electrophoresis in patients presenting as SS.
authors.affiliation: Department of Medicine, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India. upk30@rediffmail.com
authors.forename: U P
authors.initials: UP
authors.lastname: Kulkarni
authors.forename: Y A
authors.initials: YA
authors.lastname: Gokhale
authors.forename: P M
authors.initials: PM
authors.lastname: Raut
authors.forename: R R
authors.initials: RR
authors.lastname: Dargad
mesh_terms: D003937:Diagnosis, Differential; D004586:Electrophoresis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis*; D012859:Sjogren's Syndrome / Q000209:etiology*; D005719:gamma-Globulins / Q000032:analysis
chemical_list: D005719:gamma-Globulins