title: B7-h1 and a mathematical model for cytotoxic T cell and tumor cell interaction.
abstract: The surface protein B7-H1, also called PD-L1 and CD274, is found on carcinomas of the lung, ovary, colon, and melanomas but not on most normal tissues. B7-H1 has been experimentally determined to be an antiapoptotic receptor on cancer cells, where B7-H1-positive cancer cells have been shown to be immune resistant, and in vitro experiments and mouse models have shown that B7-H1-negative tumor cells are significantly more susceptible to being repressed by the immune system. We derive a new mathematical model for studying the interaction between cytotoxic T cells and tumor cells as affected by B7-H1. By integrating experimental data into the model, we isolate the parameters that control the dynamics and obtain insights on the mechanisms that control apoptosis.
authors.affiliation: Department of Mathematics and Center for Scientific Computation and Mathematical Modeling (CSCAMM), University of Maryland, College Park, MD, 20742, USA. agalante@cscamm.umd.edu
authors.forename: Amanda
authors.initials: A
authors.lastname: Galante
authors.forename: Koji
authors.initials: K
authors.lastname: Tamada
authors.forename: Doron
authors.initials: D
authors.lastname: Levy
mesh_terms: D017209:Apoptosis / Q000276:immunology*; D060890:B7-H1 Antigen / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000473:pathology
chemical_list: D060890:B7-H1 Antigen