title: Carlina oxide--a natural polyacetylene from Carlina acaulis (Asteraceae) with potent antitrypanosomal and antimicrobial properties.
abstract: Carlina acaulis (Asteraceae) has a long history of medicinal use in Europe due to its antimicrobial properties. The strong activity of Carlina oxide, themain compound of the essential oil of C. acaulis against two MRSA strains, Streptococcus pyogenes, Pseudomonas aeruginosa, Candida albicans, and C. glabrata was confirmed. A strong and selective activity against Trypanosoma brucei brucei with an IC₅₀ of 1.0 μg/mL and a SI of 446 compared to human HeLa cells was recorded. The selective toxicity of Carlina oxide makes it a promising lead compound for the development of drugs to treat African trypanosomiasis and multiresistant gram-positive bacteria.
authors.affiliation: Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Herrmann
authors.forename: Razan
authors.initials: R
authors.lastname: Hamoud
authors.forename: Frank
authors.initials: F
authors.lastname: Sporer
authors.forename: Ahmed
authors.initials: A
authors.lastname: Tahrani
authors.forename: Michael
authors.initials: M
authors.lastname: Wink
mesh_terms: D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D002175:Candida / Q000187:drug effects; D045744:Cell Line, Tumor; D005060:Europe; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D014346:Trypanosoma brucei brucei / Q000187:drug effects
chemical_list: D000480:Alkynes; D005663:Furans; D009822:Oils, Volatile; D010938:Plant Oils; C054087:carlina oxide