title: [Duration of the cell cycle phases in mutants for the tumor suppressor Merlin in Drosophila melanogaster].
abstract: The cell cycle duration was estimated in Drosophila melanogaster mutants for the tumor suppressor Merlin with the use of different approaches. Experiments on induction of mosaic clones in tissues of the larval wing imaginal disc showed that the cell cycle in mutant discs is shorter than that in control. Flow fluorescence cytometry revealed no differences between mutant and normal animals in the relative duration of the cell cycle phases, which suggests proportional shortening of the cell cycle phases. The study with pulse-labeled mitoses confirmed these results and showed that the length of the cell cycle is 7 h (S phase duration 3 h) in control individuals and 5 h (S phase duration 2 h) in Merlin gene mutants.
authors.forename: T D
authors.initials: TD
authors.lastname: Dubatolova
authors.forename: N V
authors.initials: NV
authors.lastname: Dorogova
authors.forename: L V
authors.initials: LV
authors.lastname: Omel'ianchuk
authors.forename: L-Sh
authors.initials: LS
authors.lastname: Chang
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D049109:Cell Proliferation; D004331:Drosophila melanogaster / Q000235:genetics*; D007814:Larva / Q000235:genetics; D009154:Mutation; D025581:Neurofibromin 2 / Q000235:genetics / Q000378:metabolism; D013997:Time Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism; D014921:Wings, Animal / Q000166:cytology / Q000378:metabolism
chemical_list: D025581:Neurofibromin 2; D025521:Tumor Suppressor Proteins; C099885:merlin, Drosophila