title: Primary schwannoma of the bone: a clinicopathologic and radiologic study of 17 cases.
abstract: Primary schwannoma of the bone, defined as arising within the medullary cavity and radiologically mimicking more common primary bone tumors, is rare. We present 17 tumors, 13 conventional schwannomas, and 4 melanotic type. Collectively, they represented <1% of all primary bone tumors seen at Mayo Clinic over a 33-year period. Most tumors affected long bones. There was a slight female predilection. Fifteen tumors were sporadic, and 2 were syndrome associated (Carney complex). Pain was the most common symptom. Given their rarity, schwannomas of the bone are not usually included in the differential diagnosis of primary osseous spindle cell tumors. Thus, they are prone to misdiagnosis and overtreatment. Similar to their more common extraosseous counterparts, primary schwannomas of the bone behave in a benign manner and are successfully treated by local excision alone.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Cristiane M
authors.initials: CM
authors.lastname: Ida
authors.forename: Bernd W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yapicier
authors.forename: J Aidan
authors.initials: JA
authors.lastname: Carney
authors.forename: Doris E
authors.initials: DE
authors.lastname: Wenger
authors.forename: Carrie Y
authors.initials: CY
authors.lastname: Inwards
authors.forename: Franco
authors.initials: F
authors.lastname: Bertoni
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Spinner
authors.forename: Krishnan K
authors.initials: KK
authors.lastname: Unni
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002648:Child; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009442:Neurilemmoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor