title: Progress on plague vaccine development.
abstract: Yersinia pestis (YP), the gram-negative plague bacterium, has shaped human history unlike any other pathogen known to mankind. YP (transmitted by the bite of an infected flea) diverged only recently from the related enteric pathogen Yersinia pseudotuberculosis but causes radically different diseases. Three forms of plague exist in humans: bubonic (swollen lymph nodes or bubos), septicemic (spread of YP through the lymphatics or bloodstream from the bubos to other organs), and contagious, pneumonic plague which can be communicated via YP-charged respiratory droplets resulting in person-person transmission and rapid death if left untreated (50-90% mortality). Despite the potential threat of weaponized YP being employed in bioterrorism and YP infections remaining prevalent in endemic regions of the world where rodent populations are high (including the four corner regions of the USA), an efficacious vaccine that confers immunoprotection has yet to be developed. This review article will describe the current vaccine candidates being evaluated in various model systems and provide an overall summary on the progress of this important endeavor.
authors.affiliation: Department of Biology, Center for Bionanotechnology and Environmental Research (CBER), Texas Southern University, 3100 Cleburne Street, Houston, TX 77004, USA. rosenzweigja@tsu.edu
authors.forename: Jason A
authors.initials: JA
authors.lastname: Rosenzweig
authors.forename: Olufisayo
authors.initials: O
authors.lastname: Jejelowo
authors.forename: Jian
authors.initials: J
authors.lastname: Sha
authors.forename: Tatiana E
authors.initials: TE
authors.lastname: Erova
authors.forename: Sheri M
authors.initials: SM
authors.lastname: Brackman
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Kirtley
authors.forename: Cristina J
authors.initials: CJ
authors.lastname: van Lier
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Chopra
mesh_terms: D000818:Animals; D035843:Biomedical Research; D023482:Bioterrorism / Q000517:prevention & control; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010930:Plague / Q000517:prevention & control*; D010931:Plague Vaccine / Q000276:immunology; D015010:Yersinia pestis / Q000276:immunology*
chemical_list: D010931:Plague Vaccine