title: Three-dimensional high-resolution imaging of gold nanorods uptake in sentinel lymph nodes.
abstract: In this paper, we demonstrate an application of a noninvasive imaging modality, photothermal optical coherence tomography (PT-OCT), for imaging gold nanorods (GNRs) uptake in sentinel lymph node (SLN) of mice in situ. This application enables us to obtain higher quality images of SLN structures due to the photothermal contrast properties of the GNRs. It is also demonstrated that GNRs accumulate differently within several SLN structures, and this uptake is time dependent. Finally, we determine the average concentration of GNRs within the whole SLN which is used to demonstrate uptake kinetics of the nanoparticles.
authors.affiliation: Department of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, Washington 98195, United States.
authors.forename: Yeongri
authors.initials: Y
authors.lastname: Jung
authors.forename: Roberto
authors.initials: R
authors.lastname: Reif
authors.forename: Yaguang
authors.initials: Y
authors.lastname: Zeng
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
mesh_terms: D000818:Animals; D006046:Gold / Q000737:chemistry / Q000493:pharmacokinetics*; D007700:Kinetics; D008198:Lymph Nodes / Q000473:pathology*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D057054:Molecular Imaging; D036103:Nanotechnology; D010316:Particle Size; D013499:Surface Properties; D014018:Tissue Distribution
chemical_list: D006046:Gold