title: The association of circulating adiponectin levels with pancreatic cancer risk: a study within the prospective EPIC cohort.
abstract: Excess body weight and type 2 diabetes mellitus, risk factors of pancreatic cancer, are characterized by decreased levels of adiponectin. In addition to anti-inflammatory and anti-proliferative actions, adiponectin has an important role in regulating glucose metabolism, i.e., decreasing circulating blood glucose levels. Prospectively, hyperglycemia has been associated with risk of pancreatic cancer. The aim of this study was to investigate the association of pre-diagnostic adiponectin levels with pancreatic cancer risk. We conducted a case-control study nested within European Prospective Investigation into Cancer and Nutrition. Blood samples of 452 pancreatic cancer cases and 452 individually matched controls were analyzed by immunoassays. Multivariate conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Overall, adiponectin showed no association with pancreas cancer risk; however, among never smokers, higher circulating levels of adiponectin were associated with a reduction in pancreatic cancer risk (OR = 0.44 [95% CI 0.23-0.82] for highest vs. lowest quartile), whereas among current smokers there was no significant association (OR = 1.59 [95% CI 0.67-3.76] for highest vs. lowest quartile; p-trend = 0.530; p-interaction = 0.309). In our study, lower adiponectin concentrations may be associated with the development of pancreatic cancer among never smokers, whereas the only other prospective study being conducted so far showed a decrease in risk among male smokers. Therefore, further studies are needed to clarify the role of adiponectin in pancreatic cancer development.
authors.affiliation: German Cancer Research Center, Heidelberg, Germany.
authors.forename: Verena A
authors.initials: VA
authors.lastname: Grote
authors.forename: Sabine
authors.initials: S
authors.lastname: Rohrmann
authors.forename: Laure
authors.initials: L
authors.lastname: Dossus
authors.forename: Alexandra
authors.initials: A
authors.lastname: Nieters
authors.forename: Jytte
authors.initials: J
authors.lastname: Halkjaer
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Jakob
authors.initials: J
authors.lastname: Stegger
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chabbert-Buffet
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Birgit
authors.initials: B
authors.lastname: Teucher
authors.forename: Susen
authors.initials: S
authors.lastname: Becker
authors.forename: Jukka
authors.initials: J
authors.lastname: Montonen
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Pagona
authors.initials: P
authors.lastname: Lagiou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Sabina
authors.initials: S
authors.lastname: Sieri
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.forename: Marcial
authors.initials: M
authors.lastname: Argüelles
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Duell
authors.forename: Esther
authors.initials: E
authors.lastname: Molina-Montes
authors.forename: Nerea
authors.initials: N
authors.lastname: Larrañaga
authors.forename: María-Dolores
authors.initials: MD
authors.lastname: Chirlaque
authors.forename: Aurelio Barricarte
authors.initials: AB
authors.lastname: Gurrea
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Jeurnink
authors.forename: Petra Hm
authors.initials: PH
authors.lastname: Peeters
authors.forename: Weimin
authors.initials: W
authors.lastname: Ye
authors.forename: Malin
authors.initials: M
authors.lastname: Sund
authors.forename: Björn
authors.initials: B
authors.lastname: Lindkvist
authors.forename: Dorthe
authors.initials: D
authors.lastname: Johansen
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Nick
authors.initials: N
authors.lastname: Wareham
authors.forename: Francesca L
authors.initials: FL
authors.lastname: Crowe
authors.forename: Isabelle
authors.initials: I
authors.lastname: Romieu
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Dora
authors.initials: D
authors.lastname: Romaguera
authors.forename: Dominique S
authors.initials: DS
authors.lastname: Michaud
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: H
authors.initials: H
authors.lastname: Bas Bueno-de-Mesquita
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood*; D012306:Risk; D012907:Smoking
chemical_list: D052242:Adiponectin