title: Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp.
abstract: Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A₂ (PLA₂), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA₂ inhibition (IC₅₀ 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
authors.affiliation: Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
authors.forename: Arlette
authors.initials: A
authors.lastname: Longeon
authors.affiliation: Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
authors.forename: Brent R
authors.identifier: 0000-0001-5492-5269
authors.initials: BR
authors.lastname: Copp
authors.affiliation: Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Quévrain
authors.affiliation: Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Roué
authors.affiliation: Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
authors.forename: Betty
authors.initials: B
authors.lastname: Kientz
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Centre de Recherche de Gif, avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Cresteil
authors.affiliation: Centre Polynésien de Recherche sur la Biodiversité Insulaire, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, Polynésie française, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Petek
authors.affiliation: Centre Polynésien de Recherche sur la Biodiversité Insulaire, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, Polynésie française, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Debitus
authors.affiliation: Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
authors.forename: Marie-Lise
authors.initials: ML
authors.lastname: Bourguet-Kondracki
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification; D001798:Blood Proteins / Q000302:isolation & purification; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001798:Blood Proteins; D007211:Indoles; C400481:PLIalpha