title: Intestinal pseudo-obstruction syndrome in systemic lupus erythematosus.
abstract: Intestinal pseudo-obstruction (IpsO) occurs in a small subgroup of patients with systemic lupus erythematosus (SLE), and has been under-recognized. The etiology and mechanisms are unclear. Herein, we report two cases. In case 1, IpsO occurred as the complication in a previously diagnosed SLE patient. In case 2, IpsO with an image-evidenced intussusception and a peripheral eosinophilia, was the initial presentation, leading to the diagnosis of SLE. In both cases, IpsO existed concomitantly with ureterohydronephrosis, and evolved into peritonitis, which we called together IpsO syndrome. However, this surgical abdomen-like syndrome had a satisfactory response to glucocorticosteroids instead of antibiotics and surgery. Physician awareness and early diagnosis could positively affect outcomes of this syndrome, avoiding unnecessary surgical intervention.
authors.affiliation: Nephrology Department, First Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Fang
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Mao
authors.forename: X
authors.initials: X
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D004802:Eosinophilia / Q000209:etiology; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D007443:Intussusception / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D010538:Peritonitis / Q000209:etiology; D013577:Syndrome; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones