title: [Structural genomic damages in workers of plutonium production].
abstract: The research objective is assessment of structural genomic damages in plutonium workers. The study group included the Mayak nuclear workers subject to chronic occupational exposure to incorporated 239Pu and/or external gamma-rays. The analysis was performed based on the culture of lymphocytes in peripheral blood. The yield of intra-chromosomal exchange aberrations of chromosomal type on stained slides was analyzed using in situ fluorescent hybridization, mBAND. Linear relationships were revealed between (a) the total yield of chromosomal type aberrations (e.g. intra- and inter-chromosomal ones) and an absorbed dose from external exposure of the red bone marrow to gamma-rays, an absorbed dose from internal exposure to a-radiation from incorporated 239Pu; and (b) the yield of intra-chromosomal exchange aberrations of chromosomal type and an absorbed dose from exposure of the red bone marrow to 239Pu and 239Pu body burden.
authors.forename: N V
authors.initials: NV
authors.lastname: Sotnik
authors.forename: T V
authors.initials: TV
authors.lastname: Azizova
authors.forename: S V
authors.initials: SV
authors.lastname: Osovets
mesh_terms: D000368:Aged; D001822:Body Burden; D002869:Chromosome Aberrations / Q000528:radiation effects* / Q000706:statistics & numerical data; D020732:Cytogenetic Analysis; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D015894:Genome, Human / Q000528:radiation effects*; D006801:Humans; D016018:Least-Squares Analysis; D016014:Linear Models; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D009688:Nuclear Reactors; D016273:Occupational Exposure / Q000009:adverse effects*; D011005:Plutonium / Q000097:blood; D012426:Russia
chemical_list: D011005:Plutonium