title: Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway.
abstract: Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pancreatic cancer cell lines, we have demonstrated that the flavonoid myricetin induced pancreatic cancer cell death in vitro via apoptosis, and caused a decrease in PI3 kinase activity. In vivo, treatment of orthotopic pancreatic tumors with myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer.
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, 55455, United States.
authors.forename: P A
authors.initials: PA
authors.lastname: Phillips
authors.forename: V
authors.initials: V
authors.lastname: Sangwan
authors.forename: D
authors.initials: D
authors.lastname: Borja-Cacho
authors.forename: V
authors.initials: V
authors.lastname: Dudeja
authors.forename: S M
authors.initials: SM
authors.lastname: Vickers
authors.forename: A K
authors.initials: AK
authors.lastname: Saluja
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004195:Disease Models, Animal; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008819:Mice, Nude; D010190:Pancreatic Neoplasms / Q000473:pathology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D015398:Signal Transduction / Q000187:drug effects*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; D000081082:Phosphoinositide-3 Kinase Inhibitors; C040015:myricetin