title: Recurrent ischemic stroke in a patient with ulcerative colitis and high levels of lipoprotein (a).
abstract: Cerebral infarction associated with ulcerative colitis is particularly rare, but clinically important because of its high morbidity and mortality. The pathogenesis of thrombosis in ulcerative colitis remains unclear even if platelet and coagulation cascade abnormalities, systemic inflammation, and the presence of other well recognized vascular risk factors are likely to play a key role in clot formation. We report a case of a young woman with recurrent ischemic stroke secondary to the interaction between ulcerative colitis-related dysbalanced hemostasis and high levels of lipoprotein (a).
authors.affiliation: Neurorehabilitation Unit, IRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 via Palermo, Messina, Italy. salbro77@tiscali.it
authors.forename: Rocco S
authors.initials: RS
authors.lastname: Calabrò
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pezzini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gervasi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pollicino
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
mesh_terms: D000924:Anticholesteremic Agents / Q000008:administration & dosage; D000925:Anticoagulants / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage; D000069059:Atorvastatin; D001780:Blood Coagulation Tests; D016893:Carotid Stenosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D000077144:Clopidogrel; D003093:Colitis, Ulcerative / Q000097:blood / Q000150:complications*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage; D006538:Heptanoic Acids / Q000008:administration & dosage; D006801:Humans; D017270:Lipoprotein(a) / Q000009:adverse effects / Q000096:biosynthesis; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011758:Pyrroles / Q000008:administration & dosage; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D013927:Thrombosis / Q000097:blood* / Q000209:etiology; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D014463:Ultrasonography
chemical_list: D000924:Anticholesteremic Agents; D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D006538:Heptanoic Acids; D017270:Lipoprotein(a); D011758:Pyrroles; D000069059:Atorvastatin; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin