title: Risk of in-stent thrombus formation at one year after drug-eluting stent implantation.
abstract: BACKGROUND
  Although very late stent thrombosis is an important problem with drug-eluting stents, risks for in-stent thrombus formation have not been clarified. Therefore, we examined the risks among patient and lesion characteristics by direct visualization of the stented lesion by angioscopy.
  
  
  METHODS
  Consecutive patients (n=118) who received successful angioscopic examination of drug-eluting (sirolimus- or paclitaxel-eluting) stents at 1-year after implantation were included. Presence or absence of thrombus directly on the area of each condition determined by the combination of lesion color (white or yellow) and neointima coverage (grade 0-2) was evaluated for each stent; and the factors associated with the presence of thrombus were analyzed.
  
  
  RESULTS
  Multivariate logistic regression analysis revealed lesion color (=yellow; odds ratio [OR] 5.5, 95% confidence interval [CI] 3.0-10, p<0.001), neointima coverage (=grade 0 or 1; OR 5.5, 95% CI 2.4-13, p<0.001), and stent type (=paclitaxel-eluting stent; OR 7.6, 95% CI 3.9-15, p<0.001) as independent contributors for in-stent thrombus formation.
  
  
  CONCLUSIONS
  Yellow color of the lesion, poor neointima coverage, and use of paclitaxel-eluting stent were the risks of in-stent thrombus formation at 1 year after DES implantation.
authors.affiliation: Cardiovascular Division, Osaka Police Hospital, Osaka, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Higo
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ueda
authors.forename: Koshi
authors.initials: K
authors.lastname: Matsuo
authors.forename: Mayu
authors.initials: M
authors.lastname: Nishio
authors.forename: Akio
authors.initials: A
authors.lastname: Hirata
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Asai
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Nemoto
authors.forename: Ayaka
authors.initials: A
authors.lastname: Murakami
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kashiwase
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Kodama
mesh_terms: D000368:Aged; D017546:Angioscopy; D003116:Color; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058426:Neointima / Q000473:pathology; D017239:Paclitaxel / Q000627:therapeutic use; D012044:Regression Analysis; D012306:Risk; D012307:Risk Factors; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology
chemical_list: D017239:Paclitaxel