title: Body composition, metabolic syndrome and insulin resistance in type 1 diabetes mellitus.
abstract: OBJECTIVE
  Our aim was to determine the relationship between body fat composition, metabolic syndrome (MS), and insulin resistance in type 1 diabetes (DM1).
  
  
  METHODS
  Forty-five DM1 women (36 ± 9 years; body mass index 24.6 ± 4.4 kg/m(2)) had body composition and insulin resistance determined by dual-energy X-ray absorptiometry and estimated glucose disposal ratio (eGDR), respectively. Twenty patients (45%) had MS according to World Health Organization (WHO) criteria.
  
  
  RESULTS
  Women with DM1 and MS had increased central fat and lower eGDR than women without MS (41.9 ± 2.0 vs. 33.7 ± 1.8%; p = 0.004 and 4.99 ± 0.40 vs. 8.37 ± 0.39; p < 0.0001, respectively). Total body fat and peripheric fat were similar between the groups. Central fat negatively correlated with eGDR (r = -0.33; p = 0.03).
  
  
  CONCLUSIONS
  Central fat deposition in young non-obese DM1 women was related to MS and insulin resistance. Thus, body fat composition analysis might be important to identify DM1 patients with increased metabolic risk.
authors.affiliation: Department of Diabetes, State Institute of Diabetes and Endocrinology, Universidade Católica do Rio de Janeiro, RJ, Brazil. dmomesso@terra.com.br
authors.forename: Denise Prado
authors.initials: DP
authors.lastname: Momesso
authors.forename: Isabela
authors.initials: I
authors.lastname: Bussade
authors.forename: Giovanna A Balarini
authors.initials: GA
authors.lastname: Lima
authors.forename: Leniane Pereira Coelho
authors.initials: LP
authors.lastname: Fonseca
authors.forename: Luis Augusto Tavares
authors.initials: LA
authors.lastname: Russo
authors.forename: Rosane
authors.initials: R
authors.lastname: Kupfer
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000503:physiopathology; D000328:Adult; D001823:Body Composition / Q000502:physiology; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000503:physiopathology; D011859:Radiography; D012307:Risk Factors