title: Identification of a novel target of thiazide diuretics.
abstract: Thiazide diuretics are the older but still one of the most effective therapies for human hypertension. They are believed to act exclusively by blocking renal sodium absorption by the NaCl cotransporter NCC. We recently identified, however, a novel NaCl transport system that is expressed in intercalated cells of the collecting duct. This novel mechanism of NaCl transport operates by the combined action of 2 chloride/bicarbonate exchangers, 1 sodium-independent and 1 sodium-dependent. We propose that part of the action of thiazide occurs through blockade of this novel system.
authors.affiliation: UPMC Universtité Paris 06, INSERM UMRS 872 Team 3 and CNRS ERL7226, Laboratory of renal genomics physiology and pathophysiology, Centre de recherche des Cordeliers, Paris, France. dominique.eladari@crc.jussieu.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Eladari
authors.forename: Régine
authors.initials: R
authors.lastname: Chambrey
mesh_terms: D000042:Absorption; D000818:Animals; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D017136:Ion Transport / Q000187:drug effects; D007685:Kidney Tubules, Collecting / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D012964:Sodium / Q000493:pharmacokinetics; D012965:Sodium Chloride / Q000493:pharmacokinetics*; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*; D049992:Sodium Chloride Symporters / Q000187:drug effects*
chemical_list: D049993:Sodium Chloride Symporter Inhibitors; D049992:Sodium Chloride Symporters; D012965:Sodium Chloride; D012964:Sodium