title: Strongyloides ratti: transplantation of adults recovered from the small intestine at different days after infection into the colon of naive and infection-primed Wistar rats, and the effect of antioxidant treatment on large intestinal parasitism.
abstract: Strongyloides ratti (Nagoya strain) is unique in that a portion of adults parasitizing the small intestine withstands 'worm expulsion', which starts at around day 8 post-infection (p.i.) by host immunity, and establishes in the large intestine after day 19 p.i. To investigate the mechanism, adults obtained from the small intestine at day 7 or 19 p.i. were transplanted into the colon of infection-primed immune rats. Adults obtained at day 7 p.i. were rejected quickly, whereas those obtained at day 19 p.i. could establish infection. Moreover, the body length and the number of intrauterine eggs increased in the large intestine. In a separate experiment, large intestinal parasitism was abolished by the treatment of host rats with an anti-oxidant, butylated hydroxyanisole. These results indicate that small intestinal adults between days 7 and 19 p.i. acquired the ability to parasitize the large intestine of immune rats, and that free radicals produced by the host may have played a significant role in the process.
authors.affiliation: Department of Parasitology, Aichi Medical University, 21 Karimata, Yazako, Nagakute, Aichi-ken 480-1195, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shintoku
authors.forename: H
authors.initials: H
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Kadosaka
authors.forename: F
authors.initials: F
authors.lastname: Nagaoka
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Honda
authors.forename: E
authors.initials: E
authors.lastname: Kimura
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D049628:Body Size; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D003106:Colon / Q000469:parasitology*; D005243:Feces / Q000469:parasitology; D006790:Host-Parasite Interactions; D007421:Intestine, Small / Q000469:parasitology*; D008297:Male; D010270:Parasite Egg Count; D051381:Rats; D017208:Rats, Wistar; D017170:Strongyloides ratti / Q000187:drug effects / Q000472:pathogenicity*; D013322:Strongyloidiasis / Q000469:parasitology*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D002083:Butylated Hydroxyanisole