title: Highly selective rhodium catalyzed domino C-H activation/cyclizations.
abstract: The direct functionalization of carbon-hydrogen bonds is an emerging tool to establish more sustainable and efficient synthetic methods. We present its implementation in a cascade reaction that provides a rapid assembly of functionalized indanylamines from simple and readily available starting materials. Careful choice of the ancillary ligand---an electron-rich bidentate phosphine ligand--enables highly diastereoselective rhodium(i)-catalyzed intramolecular allylations of unsubstituted ketimines induced by a directed C-H bond activation and allene carbo-metalation sequence.
authors.affiliation: Ecole polytechnique fédérale de Lausanne, EPFL SB ISIC LCSA, BCH 4305, CH-1015 Lausanne.
authors.forename: Duc N
authors.initials: DN
authors.lastname: Trans
authors.forename: Nicolai
authors.initials: N
authors.lastname: Cramer
mesh_terms: D000466:Alkadienes / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006859:Hydrogen / Q000737:chemistry; D007189:Indans / Q000138:chemical synthesis*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000466:Alkadienes; D007189:Indans; C025947:propadiene; D002244:Carbon; D006859:Hydrogen; D012238:Rhodium