title: Functional recovery in cerebral palsy may be potentiated by administration of selective serotonin reuptake inhibitors.
abstract: Cerebral palsy is a disorder of movement and posture caused by a non-progressive lesion to the brain. The incidence of cerebral palsy is over 2 per 1000 live births in Europe. Management of cerebral palsy is primarily supportive--none of the current treatments offered attempt to correct the primary problem of a brain lesion. Neurological problems may be treated by upregulating cerebral plasticity. Evidence suggests that this is the mechanism of action of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression. Encouraging evidence of motor improvements in stroke patients treated with SSRIs suggest the possibility of similar improvements in cerebral palsy. Patients with less severe cerebral palsy show more evidence of plasticity than patients with more severe forms. Evidence should initially come from animal models, and thereafter case reports and case series in selected cases, before progression to large scale trials. SSRIs would have to be used in conjunction with cooling, which prevents secondary damage. Due consideration is needed to prevent harmful side-effects.
authors.affiliation: New College, University of Oxford, Holywell Street, Oxford OX1 3BN, United Kingdom. sanjay.budhdeo@new.ox.ac.uk
authors.forename: Sanjay
authors.initials: S
authors.lastname: Budhdeo
authors.forename: Shabna
authors.initials: S
authors.lastname: Rajapaksa
mesh_terms: D002547:Cerebral Palsy / Q000188:drug therapy*; D006801:Humans; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000187:drug effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020521:Stroke / Q000188:drug therapy
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors