title: Long-term survival in a pediatric patient with supratentorial primitive neuro-ectodermal tumor and extraneural metastasis at diagnosis.
abstract: Extraneural metastases of central nervous system (CNS) tumors are rare occurrences most commonly observed in medulloblastomas. Survival outcomes are generally dismal. Supratentorial primitive neuroectodermal tumors (stPNET) are rare childhood tumors with few documented cases of extraneural metastases. We present a rare occurrence of a 23-month-old patient with long-term survival after diagnosis of stPNET with metastases to the lungs. This patient was treated with surgical resection, induction chemotherapy, tandem autologous hematopoietic cell rescues, and focal radiotherapy. We report long-term survival for a patient with a stPNET and extraneural metastases at diagnosis following an intensive approach to treatment.
authors.affiliation: Division of Pediatrics, Children's Memorial Hospital, Chicago, Illinois 60614, USA. jrubens@childrensmemorial.org
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Rubens
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Gosiengfiao
authors.forename: Tadanori
authors.initials: T
authors.lastname: Tomita
authors.forename: David A
authors.initials: DA
authors.lastname: Jacobsohn
authors.forename: Jason
authors.initials: J
authors.lastname: Fangusaro
mesh_terms: D001766:Blindness / Q000209:etiology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D018242:Neuroectodermal Tumors, Primitive / Q000150:complications / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D015173:Supratentorial Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome