title: Association between the MTHFR gene and Alzheimer's disease: a meta-analysis.
abstract: BACKGROUND
  The association between methylenetetrahydrofolate reductase (MTHFR) gene (rs1801133) 677C/T polymorphism and Alzheimer's disease (AD) is controversial. The objective of the study was to investigate the possible association between MTHFR 677C/T polymorphism and AD.
  
  
  METHODS
  We performed a meta-analysis pooling data from all relevant studies including 3,299 cases and 4,363 controls. We applied a random-effects or fixed-effects model to combine odds ratio (OR) and 95% confidence intervals (95% CI).
  
  
  RESULTS
  This meta-analysis demonstrated that the MTHFR T allele or dominant model for T allele (CT + TT) had an increased risk for AD in combined populations (OR, 95% CI: 1.13, 1.05-1.21; 1.18, 1.07-1.31, respectively), and a significant association was found in allele contrast, recessive, and dominant model in Asian populations, but not in Caucasian populations.
  
  
  CONCLUSIONS
  The MTHFR C677T polymorphism is associated with AD in Asian populations, but not in Caucasians.
authors.affiliation: Department of Neurology, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Hua
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Yuenan
authors.initials: Y
authors.lastname: Kong
authors.forename: Min
authors.initials: M
authors.lastname: Ye
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)