title: Trp-Trp pairs as β-hairpin stabilisers: hydrogen-bonded versus non-hydrogen-bonded sites.
abstract: Trp-Trp pairs have emerged as a successful strategy for β-hairpin stabilization. Using loop 3 of Vammin as a template, we experimentally demonstrate that the contribution of Trp-Trp pairs to β-hairpin stability depends on β-sheet periodicity, that is, they are stabilising at non-hydrogen-bonded sites, but not at hydrogen-bonded positions.
authors.affiliation: Instituto de Química Física Rocasolano, CSIC, Serrano 119, 28006, Madrid, Spain.
authors.forename: Clara M
authors.initials: CM
authors.lastname: Santiveri
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Pérez de Vega
authors.forename: Rosario
authors.initials: R
authors.lastname: González-Muñiz
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Jiménez
mesh_terms: D001665:Binding Sites; D006859:Hydrogen / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D017510:Protein Folding; D017433:Protein Structure, Secondary; D014364:Tryptophan / Q000737:chemistry*
chemical_list: D006859:Hydrogen; D014364:Tryptophan