title: Effect of Ligusticum wallichii aqueous extract on oxidative injury and immunity activity in myocardial ischemic reperfusion rats.
abstract: We investigated the efficacy of Ligusticum wallichi aqueous extract (LWE) for myocardial protection against ischemia-reperfusion injury. Rats were fed for five weeks with either a control diet (sham and ischemia reperfusion (IR) model control groups) or a diet mixed with 0.2%, 0.4% or 0.6% Ligusticum wallichi extract. At the end of the five week period, hearts were excised and subjected to global ischemia for 30 min followed by reperfusion for 2 h. The hearts were compared for indices of oxidative stress and immunity activities. Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities. The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.
authors.affiliation: Department of Cardiology, Fengxian Branch of Shanghai 6th People's Hospital, Shanghai, 201400 China; E-Mails: liuhjdrfx@sina.cn (L.H.); E-Mail: majwdrfx@sina.cn (M.J.).
authors.forename: Qiao
authors.initials: Q
authors.lastname: Zengyong
authors.forename: Ma
authors.initials: M
authors.lastname: Jiangwei
authors.forename: Liu
authors.initials: L
authors.lastname: Huajin
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects*; D030004:Ligusticum / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D010088:Oxidoreductases / Q000097:blood; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014867:Water / Q000737:chemistry
chemical_list: D016207:Cytokines; D010936:Plant Extracts; D014867:Water; D009569:Nitric Oxide; D008315:Malondialdehyde; D010088:Oxidoreductases