title: Distinctive neurons of the anterior cingulate and frontoinsular cortex: a historical perspective.
abstract: Human anterior cingulate and frontoinsular cortices participate in healthy social-emotional processing. These regions feature 2 related layer 5 neuronal morphotypes, the von Economo neurons and fork cells. In this paper, we review the historical accounts of these neurons and provide a German-to-English translation of von Economo's seminal paper describing the neurons which have come to bear his name. We close with a brief discussion regarding the functional and clinical relevance of these neurons and their home regions.
authors.affiliation: Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. wseeley@memory.ucsf.edu
authors.forename: William W
authors.initials: WW
authors.lastname: Seeley
authors.forename: Florian T
authors.initials: FT
authors.lastname: Merkle
authors.forename: Stephanie E
authors.initials: SE
authors.lastname: Gaus
authors.forename: A D Bud
authors.initials: AD
authors.lastname: Craig
authors.forename: John M
authors.initials: JM
authors.lastname: Allman
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Hof
authors.forename: C V
authors.initials: CV
authors.lastname: Economo
mesh_terms: D005625:Frontal Lobe / Q000166:cytology*; D006179:Gyrus Cinguli / Q000166:cytology*; D006801:Humans; D009474:Neurons / Q000502:physiology*