title: Scaffolds combined with stem cells and growth factors in healing of pseudotumoral lesions of bone.
abstract: Reconstructions of large lesions or defects often require a bone graft or a bone substitute to promote healing. In common practice the reconstruction of a bone defect is dependent on the site and size of the lesion: in long bones intercalary defects may be managed with Ilizarov technique of bone transport and distraction osteogenesis or the use of a free or pedicled vascularized bone graft, or with Masquelet technique. For cavitary defects the available surgical options include autograft, allograft or xenograft or the use of synthetic scaffolds to promote bone regeneration. In order to promote a faster bone healing tissue engineering proposed the application of enriched graft to fill bone defects. The employment of enriched bone graft has been our choice in the last years to fill contained defects following curettage of a pseudotumoral lesion of bone. We report our clinical experience in terms of safety and success of these procedures at a long-term follow up.
authors.affiliation: Azienda Ospedaliero Universitaria Careggi, CTO, Firenze, Dipartimento ad Attività Integrata di Ortopedia, SOD di Ortopedia Oncologica e Chirurgia Ricostruttiva. piedeb@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: De Biase
authors.forename: D A
authors.initials: DA
authors.lastname: Campanacci
authors.forename: G
authors.initials: G
authors.lastname: Beltrami
authors.forename: G
authors.initials: G
authors.lastname: Scoccianti
authors.forename: L
authors.initials: L
authors.lastname: Ciampalini
authors.forename: O
authors.initials: O
authors.lastname: Pecchioli
authors.forename: R
authors.initials: R
authors.lastname: Capanna
mesh_terms: D001847:Bone Diseases / Q000628:therapy*; D016026:Bone Marrow Transplantation / Q000379:methods*; D001859:Bone Neoplasms / Q000601:surgery; D003239:Connective Tissue Cells; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D006104:Granuloma, Plasma Cell / Q000628:therapy*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D017713:Platelet Transfusion; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
chemical_list: D004343:Drug Implants; D036341:Intercellular Signaling Peptides and Proteins