title: Effect of antioxidants on the clinical outcome of patients with nasal polyposis.
abstract: OBJECTIVE
  To investigate the therapeutic effects of antioxidants on the clinical and biochemical outcome of patients with nasal polyposis.
  
  
  METHODS
  Thirty-four patients with nasal polyposis were divided into two groups receiving either intranasal steroid or intranasal steroid plus per-oral vitamins A, C and E and selenium. Paranasal sinus computed tomography, endoscopy, and polyp tissue and serum sampling were conducted pre- and post-therapy. Serum levels of malondialdehyde, superoxide dismutase, nitrite and myeloperoxidase and tissue levels of malondialdehyde and superoxide dismutase were measured. Group results were compared using the Mann-Whitney U test and Wilcoxon signed-rank test.
  
  
  RESULTS
  Both groups had significantly lower tissue parameters, computed tomography scores and serum malondialdehyde levels, comparing pre- versus post-treatment results. Post-treatment, the steroid plus antioxidant group had significantly lower tissue malondialdehyde levels and a greater fall in tissue and serum malondialdehyde, compared with the steroid group.
  
  
  CONCLUSIONS
  Serum and tissue levels of malondialdehyde (an oxidative marker) were significantly decreased by adding antioxidants to standard therapy. This is the first report of the positive effects of adding antioxidants to steroid therapy for nasal polyposis.
authors.affiliation: Department of ENT, Kayseri Training and Research Hospital, Kayseri, Turkey. musagit@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Sagit
authors.forename: H
authors.initials: H
authors.lastname: Erdamar
authors.forename: C
authors.initials: C
authors.lastname: Saka
authors.forename: S
authors.initials: S
authors.lastname: Yalcin
authors.forename: I
authors.initials: I
authors.lastname: Akin
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D016166:Free Radical Scavengers / Q000097:blood; D005609:Free Radicals / Q000009:adverse effects; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D000068656:Mometasone Furoate; D009298:Nasal Polyps / Q000188:drug therapy* / Q000378:metabolism; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D011244:Pregnadienediols / Q000627:therapeutic use; D012643:Selenium / Q000494:pharmacology / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome; D014801:Vitamin A / Q000494:pharmacology / Q000627:therapeutic use; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D009573:Nitrites; D011244:Pregnadienediols; D000068656:Mometasone Furoate; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde; D009195:Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; D001205:Ascorbic Acid