title: A retunable surface coil for high field 31P and 1H magnetic resonance evaluations of the living mouse leg.
abstract: This study presents a retunable surface coil that can be adjusted to at least two Larmor frequencies sequentially without the need to remove the coil from the magnet and while avoiding interference between channels. A prototype (1)H/(31)P surface coil for the analysis of the in vivo mouse leg under electrical stimulation was designed for operation at 11.75 T. The coil has a high-quality factor of over 100 for both operational frequencies. To demonstrate the capabilities of this simple design, in vivo experiments were conducted to acquire high-resolution (1)H images and (31)P spectra of the C57BL/6 mouse leg, both with high temporal resolution. Proton diffusion tensor imaging was also performed to evaluate rodent skeletal muscle architecture. This design makes the acquisition of physiological data about both muscle structure and energetics (PCr, ATP and Pi) possible in a single experimental session.
authors.affiliation: Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, The Florida State University, Tallahassee, FL 32310, USA.
authors.forename: Ihssan S
authors.initials: IS
authors.lastname: Masad
authors.forename: Samuel C
authors.initials: SC
authors.lastname: Grant
mesh_terms: D000818:Animals; D056324:Diffusion Tensor Imaging; D005069:Evaluation Studies as Topic; D006614:Hindlimb / Q000502:physiology*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000502:physiology; D010710:Phosphates / Q000378:metabolism; D010759:Phosphorus Isotopes; D011522:Protons; D013499:Surface Properties
chemical_list: D010710:Phosphates; D010759:Phosphorus Isotopes; D011522:Protons