title: Ethyl acetate extracts of raw and steamed Codonopsis lanceolata protects against ischemic damage potentially by maintaining SOD1 and BDNF levels.
abstract: We observed the neuroprotective effects of ECLs treatment on ischemic damage in the gerbil hippocampal CA1 region four days after an ischemic insult. Among the 10 ECLs, EERCL and EESCL showed significant neuroprotection: the percentage of neurons remaining after treatment with EERCL and EESCL was 72.7% and 68.4% of that seen in the sham-ischemia group, respectively. The administration of EERCL and EESCL significantly decreased the reactive gliosis of microglia compared with that seen in the vehicle-treated ischemia group. In addition, SOD1 and BDNF immunoreactivity in the EERCL- and EESCL-ischemia groups were markedly increased compared with that in the vehicle-treated ischemia group. These results suggest that the administration of EERCL and EESCL can reduce ischemic neuronal loss potentially by maintaining SOD1 and BDNF immunoreactivity in the ischemic hippocampal CA1 region.
authors.affiliation: Department of Oral Anatomy, College of Dentistry, Gangneung-Wonju National University, Gangneung, South Korea.
authors.forename: Ki-Yeon
authors.initials: KY
authors.lastname: Yoo
authors.forename: Choong Hyun
authors.initials: CH
authors.lastname: Lee
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Joon Ha
authors.initials: JH
authors.lastname: Park
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Il-Jun
authors.initials: IJ
authors.lastname: Kang
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D056547:CA1 Region, Hippocampal / Q000473:pathology*; D029745:Codonopsis / Q000737:chemistry*; D004195:Disease Models, Animal; D005452:Fluoresceins; D005849:Gerbillinae; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005911:Gliosis / Q000517:prevention & control; D007511:Ischemia / Q000150:complications / Q000473:pathology / Q000517:prevention & control*; D037102:Lectins / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009930:Organic Chemicals / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D008517:Phytotherapy / Q000379:methods*; D018514:Plant Structures; D013482:Superoxide Dismutase / Q000378:metabolism; D000072105:Superoxide Dismutase-1
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D005452:Fluoresceins; D005904:Glial Fibrillary Acidic Protein; D037102:Lectins; D018696:Neuroprotective Agents; D009930:Organic Chemicals; C435731:fluoro jade; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D010751:Phosphopyruvate Hydratase