title: Hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves in hyperlipidemic rats.
abstract: The hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves was studied in Triton WR-1339- and high fat diet-induced hyperlipidemic rats. In Triton WR-1339-induced hyperlipidemic rats, the hexane extract (250 and 500 mg/kg) exerted a significant (P < 0.01) lipid-lowering effect compared to ethyl acetate and methanol extracts, as assessed by the reversal of the plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). In high fat diet-fed hyperlipidemic rats, the hexane extract (250 and 500 mg/kg) caused the lowering of lipid levels in the plasma and liver. The hypolipidemic activity of S. cochinchinensis leaves was compared with fenofibrate, a known lipid-lowering drug, in both models.
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India.
authors.forename: Christudas
authors.initials: C
authors.lastname: Sunil
authors.forename: Savarimuthu
authors.initials: S
authors.lastname: Ignacimuthu
authors.forename: Chidambaram
authors.initials: C
authors.lastname: Kumarappan
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D011345:Fenofibrate / Q000494:pharmacology; D006586:Hexanes / Q000737:chemistry; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D019684:Magnoliopsida / Q000737:chemistry; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D018515:Plant Leaves; D011092:Polyethylene Glycols; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006586:Hexanes; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D012997:Solvents; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol; D011345:Fenofibrate; C016811:tyloxapol