title: EMPACT syndrome.
abstract: Phenytoin is commonly used an antiepileptic medication for seizure prophylaxis in patients with brain metastases. In these oncology patients group, phenytoin-induced severe adverse reactions may occur. Antiepileptic, particularly phenytoin-induced severe skin reactions including Stevens-Johnson syndrome (SJS) and bullous form of erythema multiforme have been reported in the patients treated with cranial irradiation due to brain metastasis. The acronym EMPACT (Erythema Multiforme associated with Phenytoin And Cranial radiation Therapy) was recently described as a clinical entity. Herein, we report a 36-year-old female with breast carcinoma, who developed EMPACT syndrome after treating with cranial radiation therapy for brain metastasis and phenytoin for seizure prophylaxis.
authors.affiliation: Department of Dermatology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey. drserapgunes@yahoo.com
authors.forename: Serap Gunes
authors.initials: SG
authors.lastname: Bilgili
authors.forename: Omer
authors.initials: O
authors.lastname: Calka
authors.forename: Ayse Serap
authors.initials: AS
authors.lastname: Karadag
authors.forename: Ahmet Zubeyir
authors.initials: AZ
authors.lastname: Burakgazi
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000556:secondary; D016371:Cranial Irradiation / Q000009:adverse effects*; D004892:Erythema Multiforme / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D012640:Seizures / Q000517:prevention & control; D013577:Syndrome
chemical_list: D000927:Anticonvulsants; D005938:Glucocorticoids; D010672:Phenytoin; D011239:Prednisolone