title: Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene.
abstract: We report here a facile preparation of highly water-soluble derivatives C(70)[p-C(6)H(4)(CH(2))(n)COOH](8) (n = 2, 3) starting from readily available chlorinated [70]fullerene precursors C(70)Cl(8) and C(70)Cl(10). The synthesized fullerene derivatives showed pronounced antiviral activity in vitro, particularly against human immunodeficiency virus (HIV) and influenza A virus (subtypes H1N1 and H3N2).
authors.affiliation: IPCP RAS, Semenov Prospect 1, Chernogolovka, 141432, Russia.
authors.forename: Alexey B
authors.initials: AB
authors.lastname: Kornev
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Peregudov
authors.forename: Vyacheslav M
authors.initials: VM
authors.lastname: Martynenko
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Bart
authors.initials: B
authors.lastname: Hoorelbeke
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Troshin
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002460:Cell Line; D037741:Fullerenes / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects; D014867:Water / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D002264:Carboxylic Acids; D037741:Fullerenes; D014867:Water; C069836:fullerene C70