title: Perisomatic inhibition and cortical circuit dysfunction in schizophrenia.
abstract: Deficits of cognitive control in schizophrenia are associated with altered gamma oscillations in the prefrontal cortex. Paralbumin basket interneurons, which innervate the perisomatic region of pyramidal neurons, appear to play a key role in generating cortical gamma oscillations. In the prefrontal cortex of subjects with schizophrenia, alterations are present in both pre- and post-synaptic markers of the strength of GABA inputs from parvalbumin basket neurons to pyramidal neurons. These alterations may contribute to the neural substrate for impaired gamma oscillations in schizophrenia.
authors.affiliation: Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States. lewisda@upmc.edu
authors.forename: David A
authors.initials: DA
authors.lastname: Lewis
authors.forename: Kenneth N
authors.initials: KN
authors.lastname: Fish
authors.forename: Dominique
authors.initials: D
authors.lastname: Arion
authors.forename: Guillermo
authors.initials: G
authors.lastname: Gonzalez-Burgos
mesh_terms: D006801:Humans; D009434:Neural Pathways / Q000503:physiopathology*; D009474:Neurons / Q000473:pathology / Q000502:physiology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012559:Schizophrenia / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology*