title: Design, synthesis and SAR exploration of hybrid 4-chlorophenylthiazolyl-s-triazine as potential antimicrobial agents.
abstract: Two novel series of hybrid class 4-chlorophenylthiazole-s-triazine were synthesized via nucleophilic substitution of 2,4,6-trichloro-1,3,5-triazine with distinguished alkenyl/alkyl/aryl/hetero alkyl-aryl amino and mercapto nucleophiles under nitrogen atmosphere. We identified that the spectrums of antibacterial activity of all tested compounds reveal promising and significant inhibition of gram-positive and gram-negative micro-organisms and the most active compounds, 31d and 32d, were found to be non-toxic in preliminary cytotoxicity assay. We also report that the Molinspiration and Osiris Property Explorer calculations have found a new lead 32d, which binds preferentially to the nuclear receptor to exhibit antibacterial potency.
authors.affiliation: Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. praniori@gmail.com
authors.forename: Prashant
authors.initials: P
authors.lastname: Gahtori
authors.forename: Surajit K
authors.initials: SK
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001156:Artemia; D001419:Bacteria / Q000187:drug effects*; D015195:Drug Design; D007814:Larva / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D015996:Survival Rate; D014227:Triazines / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D014227:Triazines