title: Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle.
abstract: Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.
authors.affiliation: Program in Cell Biology, The Hospital for Sick Children, Toronto, Canada.
authors.forename: Tim T
authors.initials: TT
authors.lastname: Chiu
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Jensen
authors.forename: Lykke
authors.initials: L
authors.lastname: Sylow
authors.forename: Erik A
authors.initials: EA
authors.lastname: Richter
authors.forename: Amira
authors.initials: A
authors.lastname: Klip
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D020690:GTPase-Activating Proteins / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D020730:Guanine Nucleotide Dissociation Inhibitors / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D032342:Muscle Cells / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D010766:Phosphorylation; D021381:Protein Transport; D015398:Signal Transduction; D020830:rac1 GTP-Binding Protein / Q000378:metabolism*; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors
chemical_list: D000199:Actins; D020690:GTPase-Activating Proteins; D051275:Glucose Transporter Type 4; D020730:Guanine Nucleotide Dissociation Inhibitors; D007328:Insulin; C107953:RAC1 protein, human; C495692:SLC2A4 protein, human; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors; D020830:rac1 GTP-Binding Protein; D005947:Glucose