title: [Analysis of clinical feature and treatment outcome in 42 patients with lymphoblastic lymphoma].
abstract: OBJECTIVE
  To investigate the clinical features and treatment outcomes of different regimens in Chinese patients with lymphoblastic lymphoma (LBL).
  
  
  METHODS
  Forty-three patients with LBL were retrospectively analysed, of which 30 were T-LBL, and 13 B-LBL.
  
  
  RESULTS
  (1) Most patients were young men with a median age of 21, and 63.0% of the T-LBL patients had mediastinal masses. (2) Treatment outcome could be assessed in 37 cases, of which the response rate (RR) was 81.1% and complete remission (CR) rate was 67.6%. The RR and CR rates in patients treated with regimens for ALL (ALL-like group) and those treated with regimens for NHL (NHL-like group) were 94.4%, 68.4% and 83.3%, 52.6%, respectively. (3) The estimated median overall survival (OS) and progression free survival (PFS) of hematopoietic stem cell transplantation (HSCT) group were significant longer than those of ALL-like group (P=0.018, P=0.025) and NHL-like group (P=0.016, P=0.011). The OS at 5 years in NHL-like group, ALL-like group and HSCT group were (14.4+/-9.4)%, (20.2+/-12.7)% and (79.5+/-13.1 )%, respectively.
  
  
  CONCLUSIONS
  (1) LBL is more common in young men, with less involvement of peripheral blood. Compared with B-LBL, T-LBL often has a mediastinal mass and serious cavity effusion. (2) Intensive treatment regimens for ALL should be used in LBL. HSCT at CR1 can improve outcome obviously.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, State Key Laboratory of Experimental Hematology, Tianjin, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Lu
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: De-Hui
authors.initials: DH
authors.lastname: Zou
authors.forename: Yao-Zhong
authors.initials: YZ
authors.lastname: Zhao
authors.forename: Jun-Yuan
authors.initials: JY
authors.lastname: Qi
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Lu-Gui
authors.initials: LG
authors.lastname: Qui
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult