title: Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone).
abstract: An amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone) (PVP-b-PMMA-b-PVP) was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The block co-polymer can be directly blended with polyethersulfone (PES) using dimethylacetamide (DMAC) as the solvent to prepare flat sheet and hollow fiber membranes using a liquid-liquid phase separation technique. The PVP block formed a brush on the surface of the blended membrane, while the PMMA block mingled with the PES macromolecules, which endowed the membrane with permanent hydrophilicity. After adding the as-prepared block co-polymer the modified membranes showed lower protein (bovine serum albumin) adsorption, suppressed platelet adhesion, and a prolonged blood coagulation time, and thereby the blood compatibility was improved. Furthermore, the modified PES membranes showed good cytocompatibility, ultrafiltration and protein anti-fouling properties. These results suggest that surface modification of PES membranes by blending with the amphiphilic triblock co-polymer PVP-b-PMMA-b-PVP allows practical application of these membranes with good biocompatibility in the field of blood purification, such as hemodialysis and bioartificial liver support.
authors.affiliation: Sichuan University, Chengdu 610065, People's Republic of China.
authors.forename: Fen
authors.initials: F
authors.lastname: Ran
authors.forename: Shengqiang
authors.initials: S
authors.lastname: Nie
authors.forename: Weifeng
authors.initials: W
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Baihai
authors.initials: B
authors.lastname: Su
authors.forename: Shudong
authors.initials: S
authors.lastname: Sun
authors.forename: Changsheng
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000081:Acetamides; D000328:Adult; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D002448:Cell Adhesion; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D008567:Membranes, Artificial; D008768:Methylmethacrylates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D011145:Polyvinyls / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012997:Solvents; D013450:Sulfones / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000081:Acetamides; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D008768:Methylmethacrylates; D011108:Polymers; D011145:Polyvinyls; D011759:Pyrrolidines; D012997:Solvents; D013450:Sulfones; C022840:polyether sulfone; D012710:Serum Albumin, Bovine; C013959:dimethylacetamide