title: [Magnetic resonance cholangiographic (MRCP) features of ischemic-type biliary lesions (ITBL): a case-control study].
abstract: OBJECTIVE
  To evaluate the spectrum of MR cholangiography (MRCP) features of ischemic-type biliary lesions (ITBL) after orthotopic liver transplantation (OLT).
  
  
  METHODS
  30 patients (16 m, 14 f) with an average age of 52 years (9 - 69 y) were examined in two 1.5 MR units using breath-hold 2D-SS-FSE-sequences and 3D-MRCP sequences. 20 of the 30 patients had an established ITBL, and the remaining 10 patients were post-OLT controls. MRCPs were evaluated independently by two experienced radiologists that were blinded to the clinical history as well as the results of other imaging modalities. All images were analyzed for the presence of 16 different pathological features. Differences between ITBL patients and controls were analyzed using the Mann-Whitney-U Test. Inter-rater variability was tested using the Cohen's Kappa test.
  
  
  RESULTS
  Abnormal findings of bile ducts were seen in all patients. The most common findings were (in percentage for reader 1 / 2) intrahepatic bile duct dilatation (95 % / 95 %) and extrahepatic bile duct stenoses (95 % / 85 %), followed by intrahepatic main duct stenoses (90 % / 95 %) and segmental duct stenoses (85 % / 85 %). Differences between ITBL patients and controls were significant for most of the analyzed features (Mann-Whitney-U test, p < 0.05). For 12 of 16 features, there was substantial or almost perfect agreement (κ = 0.61 - 1.00), for 2 of 16 features moderate agreement (κ = 0.41- 0.60) and for 2 of 16 features fair agreement (κ < 0.40).
  
  
  CONCLUSIONS
  In patients with ITBL, MR cholangiography reveals characteristic features that may allow differentiation from other biliary complications after liver transplantation.
authors.affiliation: Klinik für Radiologie, Charité-Universitätsmedizin Berlin. federico.collettini@charite.de
authors.forename: F
authors.initials: F
authors.lastname: Collettini
authors.forename: T J
authors.initials: TJ
authors.lastname: Kröncke
authors.forename: C
authors.initials: C
authors.lastname: Heidenhain
authors.forename: D M
authors.initials: DM
authors.lastname: Renz
authors.forename: M
authors.initials: M
authors.lastname: de Bucourt
authors.forename: P
authors.initials: P
authors.lastname: Neuhaus
authors.forename: A
authors.initials: A
authors.lastname: Poellinger
mesh_terms: D000328:Adult; D000368:Aged; D017734:Bile Ducts, Extrahepatic / Q000098:blood supply* / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000098:blood supply* / Q000473:pathology; D016022:Case-Control Studies; D049448:Cholangiopancreatography, Magnetic Resonance; D002779:Cholestasis / Q000175:diagnosis*; D004108:Dilatation, Pathologic / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000175:diagnosis*; D006801:Humans; D006984:Hypertrophy / Q000175:diagnosis; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007511:Ischemia / Q000175:diagnosis*; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*