title: Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene.
abstract: To determine the normal function of the Coxsackievirus and Adenovirus Receptor (CAR), a protein found in tight junctions and other intercellular complexes, we constructed a mouse line in which the CAR gene could be disrupted at any chosen time point in a broad spectrum of cell types and tissues. All knockouts examined displayed a dilated intestinal tract and atrophy of the exocrine pancreas with appearance of tubular complexes characteristic of acinar-to-ductal metaplasia. The mice also exhibited a complete atrio-ventricular block and abnormal thymopoiesis. These results demonstrate that CAR exerts important functions in the physiology of several organs in vivo.
authors.affiliation: Ludwig Institutet for Cancer Research, Stockholm Branch, Stockholm, Sweden.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Pazirandeh
authors.forename: Taranum
authors.initials: T
authors.lastname: Sultana
authors.forename: Momina
authors.initials: M
authors.lastname: Mirza
authors.forename: Björn
authors.initials: B
authors.lastname: Rozell
authors.forename: Kjell
authors.initials: K
authors.lastname: Hultenby
authors.forename: Karin
authors.initials: K
authors.lastname: Wallis
authors.forename: Björn
authors.initials: B
authors.lastname: Vennström
authors.forename: Ben
authors.initials: B
authors.lastname: Davis
authors.forename: Anders
authors.initials: A
authors.lastname: Arner
authors.forename: Rainer
authors.initials: R
authors.lastname: Heuchel
authors.forename: Matthias
authors.initials: M
authors.lastname: Löhr
authors.forename: Lennart
authors.initials: L
authors.lastname: Philipson
authors.forename: Kerstin
authors.initials: K
authors.lastname: Sollerbrant
mesh_terms: D000818:Animals; D054537:Atrioventricular Block / Q000235:genetics; D001284:Atrophy / Q000235:genetics; D001522:Behavior, Animal / Q000187:drug effects; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000235:genetics; D055786:Gene Knockout Techniques; D020868:Gene Silencing / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000235:genetics; D046790:Pancreas, Exocrine / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010641:Phenotype; D011991:Receptors, Virus / Q000172:deficiency* / Q000235:genetics* / Q000378:metabolism; D013629:Tamoxifen / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: C568772:CLMP protein, mouse; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D011991:Receptors, Virus; D013629:Tamoxifen