title: A simple integrative electrophysiological model of bursting GnRH neurons.
abstract: In this paper a modular model of the GnRH neuron is presented. For the aim of simplicity, the currents corresponding to fast time scales and action potential generation are described by an impulsive system, while the slower currents and calcium dynamics are described by usual ordinary differential equations (ODEs). The model is able to reproduce the depolarizing afterpotentials, afterhyperpolarization, periodic bursting behavior and the corresponding calcium transients observed in the case of GnRH neurons.
authors.affiliation: Process Control Research Group, Computer and Automation Research Institute, Hungarian Academy of Sciences, P.O. Box 63, 1518 Budapest, Hungary. csercsik@scl.sztaki.hu
authors.forename: Dávid
authors.initials: D
authors.lastname: Csercsik
authors.forename: Imre
authors.initials: I
authors.lastname: Farkas
authors.forename: Erik
authors.initials: E
authors.lastname: Hrabovszky
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Liposits
mesh_terms: D000200:Action Potentials / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001703:Biophysics; D002118:Calcium / Q000378:metabolism; D003712:Dendrites / Q000502:physiology; D004558:Electric Stimulation; D007987:Gonadotropin-Releasing Hormone / Q000235:genetics / Q000378:metabolism*; D049452:Green Fluorescent Proteins / Q000235:genetics; D007031:Hypothalamus / Q000166:cytology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D018408:Patch-Clamp Techniques; D017553:Phosphorus Compounds / Q000494:pharmacology; D015221:Potassium Channels / Q000378:metabolism; D055366:Synaptic Potentials / Q000235:genetics / Q000502:physiology
chemical_list: D017553:Phosphorus Compounds; D015221:Potassium Channels; D049452:Green Fluorescent Proteins; D007987:Gonadotropin-Releasing Hormone; C436301:phosphorodiamidic acid; D002118:Calcium