title: Antioxidant status and biomarkers of oxidative stress in bovine leukemia virus-infected dairy cows.
abstract: Bovine leukemia virus (BLV) is among the most widespread livestock pathogens in many countries. Despite advances in understanding the pathogenesis of this disease, little is known about the involvement of oxidative stress. Therefore, this study examined the antioxidant status and the markers of oxidative stress in BLV-infected dairy cows. BLV infection was associated with an increase in triacylglycerol levels, a decrease in glutathione peroxidase (GSH-Px) activity and a tendency toward lower superoxide dismutase activity in the infected animals. No significant difference was observed in other markers of oxidative stress (i.e., conjugated dienes, hydroperoxides and malondialdehyde) in the infected animals compared to controls. A novel method for the analysis of oxidative stress, Z-scan based on the measurement of the mean-value of θ in low density lipoprotein indicated that the infected animals had low-density lipoprotein particles that were slightly less modified than those from the healthy group. Thus, we conclude that BLV infection is associated with a selective decrease in GSH-Px activity without any alteration in the common plasma markers of oxidative stress.
authors.affiliation: Department of Clinical Science, Faculty of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, 05508-270, Brazil. nogueirasouza@yahoo.com.br
authors.forename: Fernando N
authors.initials: FN
authors.lastname: Souza
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Monteiro
authors.forename: Priscilla R
authors.initials: PR
authors.lastname: dos Santos
authors.forename: Eduardo M Ramos
authors.initials: EM
authors.lastname: Sanchez
authors.forename: Maiara G
authors.initials: MG
authors.lastname: Blagitz
authors.forename: Andréia O
authors.initials: AO
authors.lastname: Latorre
authors.forename: Antônio M
authors.initials: AM
authors.lastname: Figueiredo Neto
authors.forename: Magnus
authors.initials: M
authors.lastname: Gidlund
authors.forename: Alice M M P
authors.initials: AM
authors.lastname: Della Libera
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002417:Cattle; D016583:Enzootic Bovine Leukosis / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008055:Lipids; D008077:Lipoproteins, LDL; D005979:Glutathione Peroxidase