title: [A study of traditional Chinese medicine syndromes correlated to neurologic function or to coagulation function in patients with acute cerebral infarction].
abstract: OBJECTIVE
  To investigate the correlations between traditional Chinese medicine (TCM) syndrome elements and neurologic function and between them and coagulation function in patients with acute cerebral infarction (ACI).
  
  
  METHODS
  Two hundred and twenty-three patients with ACI were enrolled. The syndromes of this disease were scored according to Stroke Diagnostic Criteria for Differentiation of Syndromes. Neurologic function deficit score (NDS) was scored according to stroke scale of the National Institutes of Health (NIHSS). The prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) contents were detected. The correlations between TCM syndrome elements and NDS and between them and coagulation function were investigated.
  
  
  RESULTS
  Two hundred and twenty-three patients with ACI were divided into six syndromes: wind syndrome (n=147, 65.92%), fire syndrome ( n=100, 44.84%), tan syndrome (n=123, 55.16%), blood stasis syndrome (n=78, 34.98%), deficiency of qi syndrome (n=31, 13.90%), and yin deficiency causing hyperactivity of yang syndrome (n=25, 11.21%). The wind, tan and fire syndromes were the main syndrome elements related to ACI. The scores of wind, fire, tan and deficiency of qi syndromes were positively related to NDS (r₁=0.207, P₁=0.002; r₂=0.284, P₂=0.000; r₃=0.245, P₃=0.000; r₄=0.152, P₄=0.023). The score of deficiency of qi syndrome was negatively correlated with PT (r=-0.170, P=0.011); and the scores of tan, blood stasis, and deficiency of qi syndromes were negatively correlated with APTT (r₁=-0.182, P₁=0.006; r₂=-0.148, P₂=0.027; r₃=-0.211, P₃=0.001).Other syndromes were not correlated to NDS or coagulation factors.
  
  
  CONCLUSIONS
  The neurologic function deficiency due to ACI is more likely influenced by wind, tan, and fire syndromes; deficiency of qi syndrome also has some effects. The syndromes of tan, blood stasis, and deficiency of qi are closely correlated with coagulation function, and their scores may reflect the clotting function in patients with ACI.
authors.affiliation: Department of Traditional Chinese Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. lj7357@vip.sina.com
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Cao
authors.forename: Hong-xun
authors.initials: HX
authors.lastname: Zhu
authors.forename: Wen-zhong
authors.initials: WZ
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D002544:Cerebral Infarction / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009420:Nervous System / Q000503:physiopathology*; D016710:Yin Deficiency; D016709:Yin-Yang