title: Kidney transplant for autosomal dominant polycystic kidney disease: the superiority of concurrent bilateral nephrectomy.
abstract: OBJECTIVE
  To assess the transplant outcome of patients who underwent concurrent bilateral nephrectomies (CBN) during kidney transplantation (KT) owing to autosomal dominant polycystic kidney disease (ADPKD).
  
  
  METHODS
  The study included 67 ADPKD patients, 4 of whom were excluded, and the rest, 63 patients, were divided into two groups: KT with CBN (group A, n = 31) and KT without CBN (group B, n = 32). Demographic factors, transplant-related factors, posttransplant complications and patient survival were compared.
  
  
  RESULTS
  There was no statistical difference in demographic or transplant-related factors between the two groups, though group A patients required more operation time (300 ± 30.85 vs. 120 ± 20.78 min, p < 0.01), needed more blood transfusion (4.31 ± 1.05 vs. 1.35 ± 0.23 U, p < 0.01) and had more adjacent organ injury during operation (22.58 vs. 0%, p < 0.01) compared with group B. However, group A patients had better relief from arterial hypertension persistence and lower urinary tract infection postoperation than group B (16/24 vs. 22/24, 6.45 vs. 31.25%, p < 0.05). Patient survival in the two groups was similar at 1 and 5 years (p > 0.05).
  
  
  CONCLUSIONS
  CBN could be safely performed during KT for patients with ADPKD. The patients could benefit from reduction of the operative procedures, better relief from arterial hypertension persistence and lower urinary tract infection posttransplantation.
authors.affiliation: Department of Transplant Surgery, Tianjin First Central Hospital, Tianjin, China. songwenli @ vip.sina.com
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Song
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Zheng
authors.forename: Chun-Bai
authors.initials: CB
authors.lastname: Mo
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Wang
authors.forename: Ying-Xin
authors.initials: YX
authors.lastname: Fu
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.forename: Zhong-Yang
authors.initials: ZY
authors.lastname: Shen
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D016891:Polycystic Kidney, Autosomal Dominant / Q000401:mortality / Q000601:surgery*; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000209:etiology