title: Alcohol-induced persistent mild cognitive impairment with successful withdrawal from alcohol dependence--a case report.
abstract: An 81-year-old man diagnosed with alcohol-induced persistent mild cognitive impairment consulted our clinic presenting with gait disturbance. Between the ages of 20 and 53 years, his alcohol consumption was 1.8 liters of alcoholic sake per day. However, from the age of 53 years onward, his consumption decreased to 360 ml per day. The patient had alcoholic neuropathy, mild cognitive impairment, and alcoholic cerebellar disorder. His score on the revised version of Hasegawa's Dementia Scale (HDS-R) was 22 and his clinical dementia rating (CDR) was 0.5. His score on the Japanese version of the Mini-Mental State Examination (MMSE) was 22. These scores indicated mild cognitive impairment (MCI). He had delusions and confabulations, without impairment of date and place orientation. Magnetic resonance imaging (MRI) demonstrated enlarged ventricles, sulcal widening, and brain atrophy. He was provided with medication and counseling to treat his alcohol abuse. He accepted our treatment and is presently doing well after 1 year 2 months of treatment.
authors.affiliation: Faculty of Health and Welfare, Prefectural University of Hiroshima, 1-1 Gakuen-machi, Mihara, Hiroshima 723-0053, Japan. hartoshi@pu-hiroshima.ac.jp
authors.forename: Toshihide
authors.initials: T
authors.lastname: Harada
authors.forename: Fumiko
authors.initials: F
authors.lastname: Ishizaki
authors.forename: Nobuko
authors.initials: N
authors.lastname: Horie
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Katsuoka
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Nitta
authors.forename: Tohru
authors.initials: T
authors.lastname: Yamada
authors.forename: Kohsaku
authors.initials: K
authors.lastname: Nitta
authors.forename: Makoto
authors.initials: M
authors.lastname: Ito
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000150:complications*; D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology*; D005684:Gait; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male