title: Highly enantioselective yttrium(III)-catalyzed Friedel-Crafts alkylation of β-trichloro(trifluoro)methyl aryl enones with indoles.
abstract: An efficient yttrium(III)-catalyzed highly enantioselective Friedel-Crafts alkylation of β-trichloro(trifluoro)methyl aryl enones is described. The reaction delivered a series of functionalized indoles with a chiral tertiary carbon center bearing a trichloro(trifluoro)methyl group in excellent results (up to 96% ee and 99% yield) under mild conditions.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Wang
authors.forename: Xiangjin
authors.initials: X
authors.lastname: Lian
authors.forename: Donghui
authors.initials: D
authors.lastname: Chen
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D054879:Halogenation; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism; D015019:Yttrium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D007211:Indoles; D007659:Ketones; D015019:Yttrium