title: Ulipristal acetate: contraceptive or contragestive?
abstract: Ulipristal acetate is the first selective progesterone receptor modulator approved for postcoital contraception in the US. It appears to be significantly more effective in inhibition of ovulation than other forms of emergency contraception. However, ulipristal acetate is structurally similar to mifepristone, and several lines of evidence suggest that a postfertilization mechanism of action is also operative. This mechanism of action is considered to be contragestive versus contraceptive. Ulipristal acetate administration is contraindicated in a known or suspected pregnancy; however, it could quite possibly be used as an effective abortifacient. Health-care providers should inform patients of the possibility of both mechanisms of action with use of this drug.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, University of Tennessee Medical Center, Knoxville, TN, USA. jkeenan@tds.net
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Keenan
mesh_terms: D044363:Contraception, Postcoital / Q000379:methods*; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D000075202:Contraindications; D017277:Drug Approval; D005260:Female; D006801:Humans; D009649:Norpregnadienes / Q000494:pharmacology*; D011247:Pregnancy; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism; D014481:United States
chemical_list: D003281:Contraceptives, Postcoital; D009649:Norpregnadienes; D011980:Receptors, Progesterone; C555622:ulipristal acetate