title: Preparation and characterization of amino-linked heterocyclic carbene palladium, gold, and silver complexes and their use as anticancer agents that act by triggering apoptotic cell death.
abstract: Transition metal complexes bearing amino linked N-heterocyclic carbenes (NHC) were prepared and evaluated for their antiproliferative activities in human cancer cells. The optimum antiproliferative activity, observed for the gold complex 3 in U-87 MG cells, was found to involve S-phase arrest of the cell cycle. The results indicate that 3 induces apoptosis through a p53-bak pathway, a finding that could serve as a new strategy to reduce the resistance of cancer cells to p53-induced apoptosis.
authors.affiliation: Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
authors.forename: Chie-Hong
authors.initials: CH
authors.lastname: Wang
authors.forename: Wei-Chih
authors.initials: WC
authors.lastname: Shih
authors.forename: Hui Chuan
authors.initials: HC
authors.lastname: Chang
authors.forename: Yi-Yin
authors.initials: YY
authors.lastname: Kuo
authors.forename: Wen-Chun
authors.initials: WC
authors.lastname: Hung
authors.forename: Tiow-Gan
authors.initials: TG
authors.lastname: Ong
authors.forename: Wen-Shan
authors.initials: WS
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019925:Cyclin A / Q000096:biosynthesis; D019926:Cyclin B / Q000096:biosynthesis; D051357:Cyclin-Dependent Kinase 2 / Q000096:biosynthesis; D004354:Drug Screening Assays, Antitumor; D006046:Gold; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010165:Palladium; D016196:S Phase; D012834:Silver; D013329:Structure-Activity Relationship; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D050998:bcl-2 Homologous Antagonist-Killer Protein / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D019925:Cyclin A; D019926:Cyclin B; D007093:Imidazoles; D016159:Tumor Suppressor Protein p53; D050998:bcl-2 Homologous Antagonist-Killer Protein; C030011:carbene; D012834:Silver; D010165:Palladium; D006046:Gold; D051357:Cyclin-Dependent Kinase 2; D008697:Methane