title: [Levodopa medications in the treatment of Parkinson's disease].
abstract: There are many medications presently available for management of Parkinson's disease. Levodopa is the most effective one. Pharmacotherapeutic efficacy of some forms of drug is not similar due to differences in composition (inactive ingredients, excipients, preservatives, colorants). Authors carried out an open labeled comparative study of pharmacotherapeutic efficacy of the original drug -- nakom and the generic one -- tidomed (both drugs include levodopa and carbidopa). The improvement as assessed by the UPDRS-3 was seen in patients receiving nakom de novo. The significant reduction of motor deficit and increase of daily activity and duration of action of a single dose were noted in patients with motor fluctuations treated with nakom.
authors.forename: N V
authors.initials: NV
authors.lastname: Fedorova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Iablonskaia
authors.forename: M E
authors.initials: ME
authors.lastname: Bel'gusheva
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D002230:Carbidopa / Q000627:therapeutic use*; D004338:Drug Combinations; D016568:Drugs, Generic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D004338:Drug Combinations; D016568:Drugs, Generic; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa