title: Association of human cytomegalovirus viremia with human leukocyte antigens in liver transplantation recipients.
abstract: Human cytomegalovirus (HCMV) reactivation is a common complication after liver transplantation (LT). Here, we investigated whether human leukocyte antigen (HLA)-matching was related to HCMV infection and subsequent graft failure after LT for hepatitis B virus  cirrhosis. This retrospective study reviewed 91 LT recipients. All the patients were grouped according to HLA-A, HLA-B, and HLA-DR locus matching. Clinical data were collected, including complete HLA-typing, HCMV viremia, graft failure, and the time of HCMV viremia. HLA typing was performed using a sequence-specific primer-polymerase chain reaction  kit. HCMV was detected by pp65 antigenemia using a commercial kit. The incidence of HCMV infection post-LT was 81.32%. Graft failure was observed in 16 of 91 (17.6%) patients during the 4-year study. The incidence of HCMV viremia was 100% (5/5), 91.4% (32/35), and 72.5% (37/51) in HLA-A two locus, one locus, and zero locus compatibility, respectively. Nevertheless, the degree of the HLA-A, HLA-B, or HLA-DR match did not influence the time of HCMV viremia, graft failure, or the time of graft failure after a diagnosis of HCMV viremia (all P > 0.05). An interesting discovery was that the risk of HCMV viremia tended to be higher in patients with better HLA-A compatibility. Graft failure, time of HCMV viremia, and graft failure after a diagnosis of HCMV viremia appear to be independent of HLA allele compatibility.
authors.affiliation: State key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Hu
authors.forename: Xueqin
authors.initials: X
authors.lastname: Meng
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Hainv
authors.initials: H
authors.lastname: Gao
authors.forename: Meifang
authors.initials: M
authors.lastname: Yang
authors.forename: Yadan
authors.initials: Y
authors.lastname: Ma
authors.forename: Minhuan
authors.initials: M
authors.lastname: Li
authors.forename: Weihang
authors.initials: W
authors.lastname: Ma
authors.forename: Jun
authors.initials: J
authors.lastname: Fan
mesh_terms: D000328:Adult; D001787:Blood Group Incompatibility / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D015234:HLA-A Antigens / Q000276:immunology; D015235:HLA-B Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014766:Viremia / Q000276:immunology*
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens