title: Analysis of the influence of two CD24 genetic variants in Crohn's disease and ulcerative colitis.
abstract: The aim of this study was to evaluate the possible implication of CD24 gene in the genetic predisposition to inflammatory bowel disease (IBD). Our study population consisted of 1321 female Spanish individuals (369 Crohn's disease [CD] patients, 323 ulcerative colitis [UC] patients, and 629 healthy matched controls). Two putative functional polymorphisms, a C to T coding polymorphism (rs8734) and a TG deletion in the 3' untranslated region (rs3838646), were used as CD24 genetic markers and genotyped using a Taqman 5' allelic discrimination assay. The "del" allele of the dinucleotide deletion was associated with an increased risk of CD (odds ratio = 1.61, 95% confidence interval = 1.17-2.21, p(FDR) = 6.4E-03) but not with UC. Moreover, this allele was significant associated with the age of CD diagnosis between 17 and 40 years, the ileocolonic location, and the inflammatory behavior of CD. We observed no significant differences between the allelic or genotypic frequencies of the A57V polymorphism in our studied IBD cohort. Our results suggest that the rs3838646 CD24 polymorphism is part of the genetic background of CD.
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain. lina.diaz@ipb.csic.es
authors.forename: Lina-Marcela
authors.initials: LM
authors.lastname: Diaz-Gallo
authors.forename: Luz María
authors.initials: LM
authors.lastname: Medrano
authors.forename: María
authors.initials: M
authors.lastname: Gómez-García
authors.forename: Carlos
authors.initials: C
authors.lastname: Cardeña
authors.forename: Luis
authors.initials: L
authors.lastname: Rodrigo
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Mendoza
authors.forename: Carlos
authors.initials: C
authors.lastname: Taxonera
authors.forename: Antonio
authors.initials: A
authors.lastname: Nieto
authors.forename: Guillermo
authors.initials: G
authors.lastname: Alcain
authors.forename: Ignacio
authors.initials: I
authors.lastname: Cueto
authors.forename: Miguel A
authors.initials: MA
authors.lastname: López-Nevot
authors.forename: Elena
authors.initials: E
authors.lastname: Urcelay
authors.forename: Javier
authors.initials: J
authors.lastname: Martin
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D051927:CD24 Antigen / Q000235:genetics*; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000235:genetics*; D003424:Crohn Disease / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017384:Sequence Deletion; D013030:Spain
chemical_list: D051927:CD24 Antigen; C497889:CD24 protein, human