title: Adverse effects of hepatitis B virus on sperm motility and fertilization ability during IVF.
abstract: The consequences of hepatitis B virus (HBV) infection for fertility are still unclear. Spermatozoa with decreased motility have been reported in HBV-infected patients. It has been demonstrated in vitro that HBV S protein has adverse effects on human sperm function with consequences for fertilization. In a case-control study design, 32 IVF cycles in couples with male HBV infection were compared with 64 cycles in non-infected couples, matched for age, time period, cycle rank and sperm parameters on the day of oocyte retrieval. Sperm motility before selection was significantly reduced in the HBV group (36.3 ± 11.6% versus 45.3 ± 14.4%,P = 0.003). A low fertilization rate (LFR) was more frequently observed in the HBV group (34.4% versus 15.6%, P = 0.036) and was associated with a decreased number of embryos available for transfer, although embryo quality on day 2 or 3 was not different.Implantation and pregnancy rates were comparable between groups. This study shows that HBV has a deleterious effect on sperm motility in vivo and that couples whose male partner is infected have a higher risk of LFR after IVF, a risk which is independent from the initial sperm motility.
authors.affiliation: Bichat Claude Bernard University Hospital, Obstetrics, Gynecology and Reproductive Medicine Dept., 46 rue Henri Huchard, 75018 Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Oger
authors.forename: Chadi
authors.initials: C
authors.lastname: Yazbeck
authors.forename: Anne
authors.initials: A
authors.lastname: Gervais
authors.forename: Béatrice
authors.initials: B
authors.lastname: Dorphin
authors.forename: Clemence
authors.initials: C
authors.lastname: Gout
authors.forename: Laetitia
authors.initials: L
authors.lastname: Jacquesson
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Ayel
authors.forename: Vanessa
authors.initials: V
authors.lastname: Kahn
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rougier
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro / Q000379:methods*; D006509:Hepatitis B / Q000150:complications*; D006515:Hepatitis B virus / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000150:complications; D008297:Male; D009865:Oocytes / Q000166:cytology; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D013081:Sperm Motility; D013094:Spermatozoa / Q000821:virology; D013997:Time Factors