title: Self-reported adherence to medical treatment prior to and during pregnancy among women with ulcerative colitis.
abstract: BACKGROUND
  Adherence to medical treatment among women with ulcerative colitis (UC) prior to and during pregnancy has never been investigated. The aim was to examine predictors for and prevalence rates of nonadherence to maintenance treatment among women with UC prior to and during pregnancy.
  
  
  METHODS
  We identified 115 women with UC having given birth during 2000-2005 within a population of 1.6 million. They received a questionnaire about predictors and adherence and relapses were registered. We retrieved information on medical treatment from prescription databases and used logistic regression to estimate prevalence odds ratios (POR) for nonadherence by different predictors.
  
  
  RESULTS
  Among 93 (81%) respondents, 63 (68%) reported taking medication, 53 of whom had filled prescriptions for relevant medication, yielding a positive predictive value of self-reported use of medical treatment of 84.1% (95% confidence interval [CI] 72.7-92.1). Approximately 60% reported adhering to medical treatment. Those who received counseling regarding medical treatment were less likely to be nonadherent compared with no counseling, especially during pregnancy (POR 0.2, 95% CI 0.04-0.94). Of those who were nonadherent, fear of a negative effect on fertility/fetus was stated as the reason by 23% prior to and by 50% during pregnancy. Notably, 40.3% reported an episode of relapse during the pregnancy period, compared with 13.6% in the period 6 months prior to pregnancy.
  
  
  CONCLUSIONS
  Adherence was high despite fear of a negative effect on fertility or the fetus. Counseling predicted higher adherence. This may be important because our study suggests an increase in UC activity during pregnancy.
authors.affiliation: Department of Medicine V, Aarhus University Hospital, Aarhus C, Denmark. mjn@ki.au.dk
authors.forename: Mette
authors.initials: M
authors.lastname: Julsgaard
authors.forename: Mette
authors.initials: M
authors.lastname: Nørgaard
authors.forename: Christian Lodberg
authors.initials: CL
authors.lastname: Hvas
authors.forename: Daniel
authors.initials: D
authors.lastname: Buck
authors.forename: Lisbet Ambrosius
authors.initials: LA
authors.lastname: Christensen
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000453:epidemiology; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D055118:Medication Adherence; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000517:prevention & control*; D015995:Prevalence; D011379:Prognosis; D055502:Secondary Prevention; D057566:Self Report; D011795:Surveys and Questionnaires; D055815:Young Adult