title: Recruiting end-of-life cancer patients in the Netherlands for a study on suffering and euthanasia requests.
abstract: BACKGROUND
  In the Netherlands, GPs performed euthanasia or physician-assisted suicide (EAS) in ∼1 of 10 end-of-life cancer patients in their care. Of all explicit requests for EAS directed at GPs, ∼44% resulted in EAS. However, the suffering of patients who do and do not request EAS has never been studied. An important barrier for such research is the low prevalence of end-of-life cancer patients per practice (on average two/year). We studied whether it is possible to recruit end-of-life cancer patients, following-up for requests for EAS (if any), in an interview study in general practice, whether selection occurred and which were the threats and opportunities to recruitment. Our target was to recruit at least 50 patients.
  
  
  METHODS
  Characteristics of all eligible patients were monitored.
  
  
  RESULTS
  One in every three eligible patients were recruited by 44 GPs in a 3-year inclusion period, resulting in 64 patients in the interview study with follow-up until death. The prevalence of explicit requests for EAS was higher (27%; P = 0.026) in the interview sample, and the presence of a depressed mood according to the GP was lower (5%; P = 0.013) than in the sample with eligible but not participating patients.
  
  
  CONCLUSIONS
  Recruitment of slightly more than the minimal target number of end-of-life cancer patients in this study in general practice was realized. Monitoring of all eligible patients permitted to evaluate the selection which occurred. Recruitment through GPs who were direct professional colleagues of one of the researchers was a positive recruitment factor.
authors.affiliation: Department of Public and Occupational Health, EMGO Institute for Health and Care Research, Palliative Care Centre of Expertise, VU University Medical Centre, Amsterdam. C.Ruys3@kpnplanet.nl
authors.forename: C D M
authors.initials: CD
authors.lastname: Ruijs
authors.forename: J
authors.initials: J
authors.lastname: Goedhart
authors.forename: A J F M
authors.initials: AJ
authors.lastname: Kerkhof
authors.forename: G
authors.initials: G
authors.lastname: van der Wal
authors.forename: B D
authors.initials: BD
authors.lastname: Onwuteaka-Philipsen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D035843:Biomedical Research / Q000379:methods*; D003863:Depression / Q000523:psychology; D033101:Euthanasia, Active, Voluntary / Q000523:psychology*; D005260:Female; D058006:General Practice; D006801:Humans; D007400:Interprofessional Relations; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000523:psychology / Q000628:therapy*; D009426:Netherlands; D010342:Patient Acceptance of Health Care; D018579:Patient Selection; D017236:Suicide, Assisted / Q000523:psychology*; D019452:Terminally Ill / Q000523:psychology*