title: Human neutrophil peptides 1, 2 and 3 (HNP 1-3): elevated serum levels in colorectal cancer and novel marker of lymphatic and hepatic metastasis.
abstract: OBJECTIVE
  Biological levels of localized colon tumors are needed for the diagnosis and prevention of colon cancer. Numerous biomarker studies are produced currently through research. We investigated some peptides with the aim of identifying biomarkers for colorectal cancer and lymphatic and hepatic metastasis.
  
  
  METHODS
  A total of 100 patients with histologically proven colorectal cancer and 60 normal volunteers were included in this study. Preoperative serum was collected for analysis. Human neutrophil peptides levels (HNP) were assayed by solid phase RIA (Radio Immun Assay) based on monoclonal antibodies.
  
  
  RESULTS
  The HNP-1, -2 and -3-also known as α-defensin-1, -2 and -3-are present in elevated concentrations in the plasma from colorectal cancer patients.
  
  
  CONCLUSIONS
  Preoperative high plasma HNP 1-3 levels are associated with colorectal cancer. The HNP 1-3 levels may procure information on patients with lymph node or hepatic metastasis.
authors.affiliation: Department of General Surgery, University of Yuzuncu Yıl, Van, Turkey. ozgurkemik@hotmail.com
authors.forename: O
authors.initials: O
authors.lastname: Kemik
authors.forename: A S
authors.initials: AS
authors.lastname: Kemik
authors.forename: A
authors.initials: A
authors.lastname: Sumer
authors.forename: H
authors.initials: H
authors.lastname: Begenik
authors.forename: S
authors.initials: S
authors.lastname: Purisa
authors.forename: S
authors.initials: S
authors.lastname: Tuzun
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D023084:alpha-Defensins / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D023084:alpha-Defensins