title: Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.
abstract: Signaling pathways essential for axon regeneration, but not for neuron development or function, are particularly well suited targets for therapeutic intervention. We find that the parallel PMK-3(p38) and KGB-1(JNK) MAPK pathways must be coordinately activated to promote axon regeneration. Axon regeneration fails if the activity of either pathway is absent. These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3(p38) and KGB-1(JNK).
authors.affiliation: Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.
authors.forename: Paola
authors.initials: P
authors.lastname: Nix
authors.forename: Naoki
authors.initials: N
authors.lastname: Hisamoto
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Michael
authors.initials: M
authors.lastname: Bastiani
mesh_terms: D000818:Animals; D001369:Axons; D001483:Base Sequence; D017931:DNA Primers; D004789:Enzyme Activation; D048670:MAP Kinase Kinase 4 / Q000378:metabolism*; D009416:Nerve Regeneration; D015398:Signal Transduction; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D017931:DNA Primers; D048051:p38 Mitogen-Activated Protein Kinases; D048670:MAP Kinase Kinase 4