title: Magnetic resonance imaging for lung cancer detection: experience in a population of more than 10,000 healthy individuals.
abstract: BACKGROUND
  Recent refinements of lung MRI techniques have reduced the examination time and improved diagnostic sensitivity and specificity. We conducted a study to assess the feasibility of MRI for the detection of primary lung cancer in asymptomatic individuals.
  
  
  METHODS
  A retrospective chart review was performed on images of lung parenchyma, which were extracted from whole-body MRI examinations between October 2000 and December 2007. 11,766 consecutive healthy individuals (mean age, 50.4 years; 56.8% male) were scanned using one of two 1.5-T scanners (Sonata and Sonata Maestro, Siemens Medical Solutions, Erlangen, Germany). The standard protocol included a quick whole-lung survey with T2-weighted 2-dimensional half Fourier acquisition single shot turbo spin echo (HASTE) and 3-dimensional volumetric interpolated breath-hold examination (VIBE). Total examination time was less than 10 minutes, and scanning time was only 5 minutes. Prompt referrals and follow-ups were arranged in cases of suspicious lung nodules.
  
  
  RESULTS
  A total of 559 individuals (4.8%) had suspicious lung nodules. A total of 49 primary lung cancers were diagnosed in 46 individuals: 41 prevalence cancers and 8 incidence cancers. The overall detection rate of primary lung cancers was 0.4%. For smokers aged 51 to 70 years, the detection rate was 1.4%. TNM stage I disease accounted for 37 (75.5%). The mean size of detected lung cancers was 1.98 cm (median, 1.5 cm; range, 0.5-8.2 cm). The most histological types were adenocarcinoma in 38 (77.6%).
  
  
  CONCLUSIONS
  Rapid zero-dose MRI can be used for lung cancer detection in a healthy population.
authors.affiliation: Institute of BioMedical Informatics, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Nai-Yuan
authors.initials: NY
authors.lastname: Wu
authors.forename: Hui-Cheng
authors.initials: HC
authors.lastname: Cheng
authors.forename: James S
authors.initials: JS
authors.lastname: Ko
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Cheng
authors.forename: Po-Wei
authors.initials: PW
authors.lastname: Lin
authors.forename: Wei-Chan
authors.initials: WC
authors.lastname: Lin
authors.forename: Cheng-Yen
authors.initials: CY
authors.lastname: Chang
authors.forename: Der-Ming
authors.initials: DM
authors.lastname: Liou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D002648:Child; D003287:Contrast Media; D055088:Early Detection of Cancer / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008403:Mass Screening / Q000379:methods* / Q000706:statistics & numerical data; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D013624:Taiwan / Q000453:epidemiology; D051598:Whole Body Imaging; D055815:Young Adult
chemical_list: D003287:Contrast Media