title: Orofacial granulomatosis associated with hypersensitivity to dental amalgam.
abstract: Orofacial granulomatosis is a clinicopathologic entity characterized by chronic swelling of the lip and possible soft tissues in the orofacial region owing to granulomatous inflammation of unknown cause. We present 3 cases of orofacial granulomatosis associated with allergic contact dermatitis to dental materials. Previous treatment with corticosteroids did not have any therapeutic effect. Patch testing revealed a positive reaction to several allergens, including dental amalgam and mercury in 2 cases. A lymphocyte transformation test modified for metals was used to evaluate lymphocyte reactivity. After the removal of the suspected allergens, all patients experienced recovery within 1 month, with the exception of the lip swelling, which gradually subsided over several months.
authors.affiliation: Institute of Dental Research, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. tomka@vus.cz
authors.forename: Milan
authors.initials: M
authors.lastname: Tomka
authors.forename: Alena
authors.initials: A
authors.lastname: Machovcová
authors.forename: Daniela
authors.initials: D
authors.lastname: Pelclová
authors.forename: Jitka
authors.initials: J
authors.lastname: Petanová
authors.forename: Monika
authors.initials: M
authors.lastname: Arenbergerová
authors.forename: Jarmila
authors.initials: J
authors.lastname: Procházková
mesh_terms: D000328:Adult; D003723:Dental Amalgam / Q000009:adverse effects*; D005260:Female; D051261:Granulomatosis, Orofacial / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008047:Lip Diseases / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D008628:Mercury / Q000009:adverse effects*; D008875:Middle Aged; D010328:Patch Tests; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003723:Dental Amalgam; D008628:Mercury