title: Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036.
abstract: D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.
authors.affiliation: Graduate Institute of Life Sciences, National Defence Medical Center, Taipei, Taiwan, ROC.
authors.forename: Yung-Ning
authors.initials: YN
authors.lastname: Yang
authors.forename: Kai-ming
authors.initials: KM
authors.lastname: Chou
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Pan
authors.forename: Yih-wen
authors.initials: YW
authors.lastname: Chen
authors.forename: Tsui-Chun
authors.initials: TC
authors.lastname: Tsou
authors.forename: Ssu-Ching
authors.initials: SC
authors.lastname: Yeh
authors.forename: Chun Hei Antonio
authors.initials: CH
authors.lastname: Cheung
authors.forename: Li-Tzong
authors.initials: LT
authors.lastname: Chen
authors.forename: Jang-Yang
authors.initials: JY
authors.lastname: Chang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D016566:Organoselenium Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D011758:Pyrroles / Q000494:pharmacology* / Q000627:therapeutic use; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: C517977:2,5-bis(5-hydroxymethyl-2-selenienyl)-3-hydroxymethyl-N-methylpyrrole; D000970:Antineoplastic Agents; D016566:Organoselenium Compounds; D011758:Pyrroles