title: Mercaptoacetyltriglycine-3 renogram is not superior to estimated glomerular filtration rate measurement for the prediction of long-term renal function after nephrectomy.
abstract: OBJECTIVE
  To evaluate the clinical usefulness of effective renal plasma flow (ERPF) measured using preoperative mercaptoacetyltriglycine-3 (MAG3) renogram for the prediction of chronic renal insufficiency after nephrectomy.
  
  
  METHODS
  A total of 47 patients underwent preoperative MAG3 renal scintigraphy and subsequent unilateral nephrectomy. Correlations between the 5-year postoperative estimated glomerular filtration rate (eGFR) and the preoperative ERPF of the contralateral kidney (cERPF), ERPF of the diseased kidney (dERPF), total ERPF (tERPF), cERPF to dERPF ratio, serum creatinine (sCr) level, eGFR, as well as the influence of preoperative comorbidities (diabetes, hypertension) on the postoperative eGFR, were evaluated with both univariate and multivariate analyses.
  
  
  RESULTS
  Multiple linear regression analysis showed that preoperative cERPF significantly correlated with postoperative eGFR. However, a much stronger correlation was observed between the preoperative and postoperative eGFR. Multiple logistic regression analysis showed that only preoperative eGFR was a significant predicator of the development of advanced-stage chronic kidney disease (CKD).
  
  
  CONCLUSIONS
  Preoperative MAG3 renogram is not superior to eGFR measurement as a prognostic indicator of long-term renal function after unilateral nephrectomy.
authors.affiliation: Department of Urology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan. h-kanamaru@kitano-hp.or.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanamaru
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Kanji
authors.initials: K
authors.lastname: Nagahama
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yagihashi
authors.forename: Keiji
authors.initials: K
authors.lastname: Kato
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Oida
authors.forename: Toru
authors.initials: T
authors.lastname: Kannno
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Takao
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Shichiri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011866:Radioisotope Renography; D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide; D013997:Time Factors
chemical_list: D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide