title: HIV-associated lung infections and complications in the era of combination antiretroviral therapy.
abstract: The spectrum of lung diseases associated with HIV is broad, and many infectious and noninfectious complications of HIV infection have been recognized. The nature and prevalence of lung complications have not been fully characterized since the Pulmonary Complications of HIV Infection Study more than 15 years ago, before antiretroviral therapy (ART) increased life expectancy. Our understanding of the global epidemiology of these diseases in the current ART era is limited, and the mechanisms for the increases in the noninfectious conditions, in particular, are not well understood. The Longitudinal Studies of HIV-Associated Lung Infections and Complications (Lung HIV) Study (ClinicalTrials.gov number NCT00933595) is a collaborative multi-R01 consortium of research projects established by the National Heart, Lung, and Blood Institute to examine a diverse range of infectious and noninfectious pulmonary diseases in HIV-infected persons. This article reviews our current state of knowledge of the impact of HIV on lung health and the development of pulmonary diseases, and highlights ongoing research within the Lung HIV Study.
authors.affiliation: Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Washington, Seattle, Washington, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Crothers
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Thompson
authors.forename: Kathryn
authors.initials: K
authors.lastname: Burkhardt
authors.forename: Alison
authors.initials: A
authors.lastname: Morris
authors.forename: Sonia C
authors.initials: SC
authors.lastname: Flores
authors.forename: Philip T
authors.initials: PT
authors.lastname: Diaz
authors.forename: Richard E
authors.initials: RE
authors.lastname: Chaisson
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Kirk
authors.forename: William N
authors.initials: WN
authors.lastname: Rom
authors.forename: Laurence
authors.initials: L
authors.lastname: Huang
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000209:etiology; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D002986:Clinical Trials as Topic; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008168:Lung / Q000276:immunology; D008171:Lung Diseases / Q000209:etiology* / Q000276:immunology; D015337:Multicenter Studies as Topic; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D044966:Anti-Retroviral Agents