title: High mobility group box 1 in cerebrospinal fluid from several neurological diseases at early time points.
abstract: The present study aimed to elucidate the possible role of High Mobility Group Box 1 (HMGB1), which is a candidate prognostic marker in diseases that combine inflammation and tissue injury, in acute encephalopathy. HMGB1 in cerebrospinal fluid (CSF) obtained on admission from eight children with acute encephalopathy, and 16 children with febrile seizure, eight children with bacterial/aseptic meningitis, and eight children with fever without neurological symptoms were analyzed using enzyme-linked immunosorbent assay (ELISA). We found no increase in HMGB1 in CSF from acute encephalopathy or in CSF from febrile seizure or fever without neurological complications at early time points, while marked elevation of HMGB1 was seen in CSF from bacterial and aseptic meningitis. In conclusion, HMGB1 is a poor disease marker for acute encephalopathy.
authors.affiliation: Department of Pediatrics, Nippon Medical School, Chiba Hokusoh Hospital, Chiba, Japan. VFF13540@nifty.ne.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Asano
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Ichiki
authors.forename: Shinya
authors.initials: S
authors.lastname: Koizumi
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Kaizu
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hatori
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Mashiko
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Taku
authors.initials: T
authors.lastname: Miyasho
authors.forename: Osamu
authors.initials: O
authors.lastname: Fujino
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Fukunaga
mesh_terms: D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D024243:HMGB1 Protein / Q000134:cerebrospinal fluid*; D006801:Humans; D007223:Infant; D008297:Male; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000145:classification; D018709:Statistics, Nonparametric
chemical_list: D024243:HMGB1 Protein