title: Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population.
abstract: OBJECTIVE
  Recently, we detected that the prokineticin 2 receptor gene was associated with not only major depressive disorder (MDD) but also methamphetamine dependence. Therefore, it is possible that mood disorders and drug addiction have shared susceptibility genes. The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder. TSNAX is located immediately upstream of DISC1 and has been shown to undergo intergenic splicing with DISC1. Based on this evidence, we hypothesized that TSNAX might be a good candidate gene for methamphetamine dependence.
  
  
  METHODS
  We conducted a case-control study of Japanese individuals (215 with methamphetamine dependence and 318 age- and sex-matched controls) with three tagging SNPs (rs1630250, rs766288 and rs6662926) selected by HapMap database.
  
  
  RESULTS
  rs1630250 was associated in males with methamphetamine dependence in the allele analysis (P-value: 0.0253). However, these results did not remain significant after Bonferroni correction to adjust for multiple comparisons (corrected P-value: 0.152).
  
  
  CONCLUSIONS
  Our findings suggest that TSNAX does not play a role in methamphetamine dependence in the Japanese population. A replication study using larger samples needs to be conducted to obtain conclusive results.
authors.affiliation: Department of Psychiatry Research, The Zucker Hillside Hospital, NY 11004, USA. tarok@fujita-hu.ac.jp
authors.forename: Taro
authors.initials: T
authors.lastname: Kishi
authors.forename: Tomo
authors.initials: T
authors.lastname: Okochi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kitajima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Yamada
authors.forename: Naohisa
authors.initials: N
authors.lastname: Uchimura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sora
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Christoph U
authors.initials: CU
authors.lastname: Correll
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
mesh_terms: D000483:Alleles; D019969:Amphetamine-Related Disorders / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D044466:Asian People / Q000235:genetics; D001714:Bipolar Disorder / Q000235:genetics; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000009:adverse effects* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D060148:HapMap Project; D006239:Haplotypes; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics
chemical_list: D000697:Central Nervous System Stimulants; C412476:DISC1 protein, human; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C498305:TSNAX protein, human; D008694:Methamphetamine