title: Access to antigens related to anthrose using pivotal cyclic sulfite/sulfate intermediates.
abstract: Anthrose is the upstream terminal unit of the tetrasaccharide side chain from a major glycoprotein of Bacillus anthracis exosporium and is part of important antigenic determinants. A novel entry to anthrose-containing antigens and precursors is described. The synthetic route, starting from D(+)-fucose, makes use of intermediates featuring a cyclic sulfite or sulfate function which serves successively as a protecting and a leaving group.
authors.affiliation: Laboratoire des Glucides, UMR CNRS 6219, Institut de Chimie de Picardie, Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens Cedex, France.
authors.forename: Ophélie
authors.initials: O
authors.lastname: Milhomme
authors.forename: Cédric
authors.initials: C
authors.lastname: John
authors.forename: Florence
authors.initials: F
authors.lastname: Djedaïni-Pilard
authors.forename: Cyrille
authors.initials: C
authors.lastname: Grandjean
mesh_terms: D001408:Bacillus anthracis / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry*; D006023:Glycoproteins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D019081:O Antigens / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D013447:Sulfites / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001426:Bacterial Proteins; D006023:Glycoproteins; D019081:O Antigens; D009844:Oligosaccharides; D013447:Sulfites