title: Anthropometric measures, physical activity, and risk of glioma and meningioma in a large prospective cohort study.
abstract: Body fatness has been associated with increased risk of a number of hormone-dependent cancers. Recent studies suggest that body mass index (BMI) may be related to meningiomas, which are more common in women than men, and for which estrogens are believed to play a role. Using data from a large European propective cohort, 203 incident cases of meningioma and 340 cases of glioma were included in the analysis for measures of body fat, height, and physical activity among 380,775 participants. All analyses were conducted using Cox proportional hazards model and controlling for age, sex, country, and education. A 71% increase in risk of meningioma was observed among men and women in the top quartile of waist circumference (HR = 1.71, 95% CI = 1.08-2.73, P(trend) = 0.01). A positive association was also observed for BMI and meningioma (HR = 1.48, 95% CI = 0.98-2.23, for BMI ≥30 compared with a BMI of 20-24.9, P(trend) = 0.05). An association with height and meningioma was also suggestive (HR = 1.24, 95% 0.96-1.51, for each 10 cm increase). In contrast, no associations were observed for height and different measures of body fat and risk of glioma. Physical activity was not related to either type of brain tumors. Results from this study support an increase in risk of meningioma with higher body fatness among both men and women. No association was observed between anthropometric measures and risk of glioma.
authors.affiliation: Department of Epidemiology and Public Health, Imperial College, London, UK. Dominique_Michaud@brown.edu
authors.forename: Dominique S
authors.initials: DS
authors.lastname: Michaud
authors.forename: Gerald
authors.initials: G
authors.lastname: Bové
authors.forename: Valentina
authors.initials: V
authors.lastname: Gallo
authors.forename: Brigitte
authors.initials: B
authors.lastname: Schlehofer
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Anja
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authors.lastname: Olsen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Christina C
authors.initials: CC
authors.lastname: Dahm
authors.forename: Brigit
authors.initials: B
authors.lastname: Teucher
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Annika
authors.initials: A
authors.lastname: Steffen
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Christina
authors.initials: C
authors.lastname: Bamia
authors.forename: Andreas
authors.initials: A
authors.lastname: Kyrozis
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.forename: Claudia
authors.initials: C
authors.lastname: Agnoli
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Petra H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: Anne M
authors.initials: AM
authors.lastname: May
authors.forename: Aurelio
authors.initials: A
authors.lastname: Barricarte
authors.forename: Maria-Dolores
authors.initials: MD
authors.lastname: Chirlaque
authors.forename: Miren
authors.initials: M
authors.lastname: Dorronsoro
authors.forename: Maria
authors.initials: M
authors.lastname: José Sánchez
authors.forename: Laudina
authors.initials: L
authors.lastname: Rodríguez
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Duell
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Beatrice S
authors.initials: BS
authors.lastname: Melin
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Signe
authors.initials: S
authors.lastname: Borgquist
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Nick
authors.initials: N
authors.lastname: Wareham
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Allen
authors.forename: Ruth C
authors.initials: RC
authors.lastname: Travis
authors.forename: Isabelle
authors.initials: I
authors.lastname: Romieu
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry / Q000379:methods; D001827:Body Height; D015992:Body Mass Index; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology; D015331:Cohort Studies; D005060:Europe; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D008579:Meningioma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D009043:Motor Activity; D016016:Proportional Hazards Models