title: Exposure to thoracic dust, airway symptoms and lung function in cement production workers.
abstract: Cement dust exposure has previously been associated with airway symptoms and ventilatory impairment. The aim of the present study was to examine lung function and airway symptoms among employees in different jobs and at different levels of exposure to thoracic dust in the cement production industry. At the start of a 4-yr prospective cohort study in 2007, exposure to cement dust, symptoms and lung function were recorded cross-sectionally in 4,265 employees in 24 European cement plants. Bronchial exposure was assessed by 2,670 full-shift dust samples with cyclones collecting the thoracic aerosol fraction. A job exposure matrix was constructed by grouping dust concentrations according to job type and plant. Elevated odds ratios for symptoms and airflow limitation (range 1.2-2.6 in the highest quartile), but not for chronic bronchitis, were found in the higher quartiles of exposure compared with the lowest quartile. Forced expiratory volume in 1 s (FEV(1)) showed an exposure-response relationship with a 270-mL deficit of FEV(1) (95% CI 190-300 mL) in the highest compared with the lowest exposure level. The results support the hypothesis that exposure to dust in cement production may lead to respiratory symptoms and airway obstruction.
authors.affiliation: National Institute of Occupational Health, PO Box 8149 Dep, NO-0033 Oslo, Norway. kcn@stami.no
authors.forename: K-C
authors.initials: KC
authors.lastname: Nordby
authors.forename: A K M
authors.initials: AK
authors.lastname: Fell
authors.forename: H
authors.initials: H
authors.lastname: Notø
authors.forename: W
authors.initials: W
authors.lastname: Eduard
authors.forename: M
authors.initials: M
authors.lastname: Skogstad
authors.forename: Y
authors.initials: Y
authors.lastname: Thomassen
authors.forename: A
authors.initials: A
authors.lastname: Bergamaschi
authors.forename: J
authors.initials: J
authors.lastname: Kongerud
authors.forename: H
authors.initials: H
authors.lastname: Kjuus
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000402:Airway Obstruction / Q000209:etiology* / Q000503:physiopathology; D029481:Bronchitis, Chronic / Q000209:etiology / Q000503:physiopathology; D015331:Cohort Studies; D003252:Construction Materials / Q000633:toxicity*; D004391:Dust; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology* / Q000503:physiopathology; D016273:Occupational Exposure; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012907:Smoking / Q000453:epidemiology; D013147:Spirometry
chemical_list: D000395:Air Pollutants, Occupational; D004391:Dust