title: [A case of recurrent endometrial cancer metastasis successfully treated with zoledronic Acid].
abstract: Although metastasis to the bone is common in solid tumors, it seldom occurs in endometrial cancer. A rare case of endometrial carcinoma that presented wth symptoms of bone metastasis in the right ischium and treated successfully by zoledronic acid is described. A 57-year-old woman presented with pain of the right ischium. Computed tomography and magnetic resonance imaging revealed bone metastasis and enlargement of the uterus. Endometrial biopsy confirmed endometrial adenocarcinoma. The patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy and biopsy of the ischium. Postoperatively, the patient received six courses of chemotherapy using paclitaxel and carboplatin. However, pain of the right-ischium reappeared 9 months after surgery. The patient was treated with 4 mg of zoledronic acid every 4 weeks. After 4 cycles of treatment, the visual analogue scale regressed from 70 to 10. Zoledronic acid can palliate bone pain caused by a variety of endometrial cancers.
authors.affiliation: Dept. of Obstetrics and Gynecology, Nara Medical University.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kawaguchi
authors.forename: Aiko
authors.initials: A
authors.lastname: Shigemitsu
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Tanase
authors.forename: Shoji
authors.initials: S
authors.lastname: Haruta
authors.forename: Akira
authors.initials: A
authors.lastname: Nagai
authors.forename: Shozo
authors.initials: S
authors.lastname: Yoshida
authors.forename: Naoto
authors.initials: N
authors.lastname: Furukawa
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yamada
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Ooi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D003131:Combined Modality Therapy; D004164:Diphosphonates / Q000627:therapeutic use*; D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012008:Recurrence; D014057:Tomography, X-Ray Computed; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid