title: Shigella gets captured to gain entry.
abstract: The type III secretion system-dependent epithelial invasion and dissemination of Shigella is stimulated by ATP released through hemichannels. Romero et al. (2011) show that prior to epithelial contact, Shigella is captured by nanometer-thin micropodial extensions at a distance from the cell surface, in a process involving ATP and connexin-mediated signaling.
authors.affiliation: Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA. beth.mccormick@umassmed.edu
authors.forename: Beth A
authors.initials: BA
authors.lastname: McCormick
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D004405:Dysentery, Bacillary / Q000201:enzymology / Q000378:metabolism / Q000382:microbiology* / Q000503:physiopathology; D004847:Epithelial Cells / Q000201:enzymology / Q000378:metabolism / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000235:genetics / Q000378:metabolism; D011554:Pseudopodia / Q000201:enzymology / Q000378:metabolism / Q000382:microbiology*; D012760:Shigella / Q000235:genetics / Q000502:physiology*
chemical_list: D000255:Adenosine Triphosphate; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3