title: Cooperativity of adaptive and innate immunity: implications for cancer therapy.
abstract: The dichotomy of immunology into innate and adaptive immunity has created conceptual barriers in appreciating the intrinsic two-way interaction between immune cells. An emerging body of evidence in various models of immune rejection, including cancer, indicates an indispensable regulation of innate effector functions by adaptive immune cells. This bidirectional cooperativity in innate and adaptive immune functions has broad implications for immune responses in general and for regulating the tumor-associated inflammation that overrides the protective antitumor immunity. Mechanistic understanding of this two-way immune cross-talk could provide insights into novel strategies for designing better immunotherapy approaches against cancer and other diseases that normally defy immune control.
authors.affiliation: Laboratory of Lymphocyte Function, Department of Biochemistry and Cancer Biology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA. ashanker@mmc.edu
authors.forename: Anil
authors.initials: A
authors.lastname: Shanker
authors.forename: Francesco M
authors.initials: FM
authors.lastname: Marincola
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002450:Cell Communication; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D019139:Tumor Escape