title: Prognostic factors for T1-T2 squamous cell carcinomas of the mobile tongue: A retrospective cohort study.
abstract: BACKGROUND
  The aim of this study was to identify factors predicting poor prognosis at the time of early oral tongue carcinoma diagnosis.
  
  
  METHODS
  A retrospective cohort study was carried out on 70 patients with T1 or T2 squamous cell carcinoma of the mobile tongue treated with primary surgical treatment.
  
  
  RESULTS
  In all, 47% of patients received adjuvant treatment. Local recurrence was observed in 29% and regional recurrence in 26%. With a median follow-up of 7.3 years for living patients, 5-year actuarial overall, disease-specific, and disease-free survival rates were 48%, 61%, and 42%, respectively. The presence of poor histological differentiation increased the overall risk of death. Tumor thickness and posterior lingual location independently increased overall and disease-specific risk of death. Concurrent or previous diagnosis of oral lichen significantly increased the risk of disease-specific death and disease recurrence.
  
  
  CONCLUSIONS
  This study corroborates several known prognostic factors and indicates that diagnosis of oral lichen planus may be a risk factor for disease recurrence.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Hôtel-Dieu Hospital, University of Nantes, Nantes, France. lbonnardot@gmail.com
authors.forename: Laurent
authors.initials: L
authors.lastname: Bonnardot
authors.forename: Etienne
authors.initials: E
authors.lastname: Bardet
authors.forename: Olivier
authors.initials: O
authors.lastname: Steichen
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Cassagnau
authors.forename: Benoit
authors.initials: B
authors.lastname: Piot
authors.forename: Alex P
authors.initials: AP
authors.lastname: Salam
authors.forename: Loïc
authors.initials: L
authors.lastname: Campion
authors.forename: Christophe
authors.initials: C
authors.lastname: Ferron
authors.forename: Claude
authors.initials: C
authors.lastname: Beauvillain de Montreuil
authors.forename: Olivier
authors.initials: O
authors.lastname: Malard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D015897:Comorbidity; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D006801:Humans; D017676:Lichen Planus, Oral / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012907:Smoking / Q000453:epidemiology; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis; D014062:Tongue Neoplasms / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D055815:Young Adult