title: Fast high-resolution 2D correlation spectroscopy in inhomogeneous fields via Hadamard intermolecular multiple quantum coherences technique.
abstract: Recently, a method based on intermolecular multiple quantum coherences (iMQCs) has been proposed to obtain high-resolution 2D COSY spectra in inhomogeneous fields via 3D acquisitions. However, the very long acquisition time prevents its practical application. To overcome this shortage, the Hadamard technique was applied for the iMQC method in this paper. For the new pulse sequence, the direct frequency-domain excitation is used in the first indirect detection dimension, so the 3D acquisition was replaced by an array of 2D acquisitions. The acquisition time can be reduced to 10 min. The resulting spectra retain useful structural information including chemical shifts and multiplet patterns of J coupling even when the inhomogeneous line broadening leads to overlap of neighboring diagonal resonances in the conventional COSY spectrum. The experimental results are consistent with the theoretical predictions and computer simulations. The new sequence may provide a time-efficient way for the studies of chemical solution in inhomogeneous fields.
authors.affiliation: Department of Electronic Science, Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, PR China.
authors.forename: Congbo
authors.initials: C
authors.lastname: Cai
authors.forename: Fenglian
authors.initials: F
authors.lastname: Gao
authors.forename: Shuhui
authors.initials: S
authors.lastname: Cai
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Huang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D006842:Hydrocarbons, Brominated / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011789:Quantum Theory
chemical_list: D006842:Hydrocarbons, Brominated; D007202:Indicators and Reagents; C047757:butyl bromide