title: Generation of quaternary centers by reductive cross-coupling: shifting of regioselectivity in a subset of allylic alcohol-based coupling reactions.
abstract: Regioselective titanium alkoxide-mediated reductive cross-coupling reactions of allylic alcohols with vinylsilanes and imines have previously been demonstrated to proceed with allylic transposition by formal metallo-[3,3]-rearrangement [thought to proceed by a sequence of: 1) directed carbometalation, and 2) syn-elimination]. While many examples have been described that support this reaction path, a collection of substrates have recently been identified that react by way of an alternative pathway, delivering a concise convergent route to coupled products bearing a quaternary center.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458.
authors.forename: Dexi
authors.initials: D
authors.lastname: Yang
authors.forename: Justin K
authors.initials: JK
authors.lastname: Belardi
authors.forename: Glenn C
authors.initials: GC
authors.lastname: Micalizio