title: Prevalence of pulmonary hypertension in patients with idiopathic pulmonary fibrosis: correlation with physiological parameters.
abstract: The aim of this study was to prospectively evaluate the prevalence of pulmonary hypertension (PH) in patients with idiopathic pulmonary fibrosis (IPF). One hundred thirty-nine patients (101 male, mean age = 68.6 ± 9 years), with confirmed IPF and who were admitted to eight Pulmonary Departments in Greece between November 2005 and December 2006 were included in the study. Pulmonary artery systolic pressure (PASP) was estimated by echocardiography, and PH was defined as PASP > 36 mmHg. We compared demographics, pulmonary function tests, NYHA functional status, 6-min walk distance (6MWD), B-type natriuretic peptide (BNP), PaO(2), and P(A-a)O(2) at rest data between patients with PH and without PH (PASP ≤ 36 mmHg). Increased estimated right ventricular systolic pressure was present in 55% of patients (mean PASP = 47.1 ± 11.2 mmHg vs. 30.3 ± 3.8 mmHg, respectively). Patients with PH had a lower but not statistically significant DL(CO) (47.1 ± 18.8 vs. 52.5 ± 20.1), lower PaO(2) at rest (64.6 ± 12.2 vs. 71.1 ± 11.3, P = 0.004), and lower mean 6MWD (282 ± 118 vs. 338 ± 91, P = 0.007). Significant differences were also observed in the NYHA functional status between the two groups (P = 0.02). Statistically significant correlations were observed between PASP and PaO(2) at rest (r = -0.331, P = 0.00), P(A-a)O(2) at rest (r = 0.494, P = 0.00)(,) 6MWD (r = -0.264, P = 0.01), SpO(2) at rest (r = -0.293, P = 0.00), SpO(2) at the end of exercise (r = -0.364, P = 0.00), and also BNP values (r = 0.319, P = 0.01). Moreover, PaO(2) (P = 0.02), P(A-a)O(2) (P = 0.005), and SpO(2) at the end of exercise (P = 0.023) were independent predictors of the presence of estimated PH. Using Doppler echocardiography as a screening tool for the estimation of PH, we found that PH is common in patients with IPF. Gas exchange parameters at rest and exercise desaturation might indicate underlying PH in IPF.
authors.affiliation: Department of Pneumonology, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Exochi, 57010, Thessaloniki, Greece. dpapakos@med.auth.gr
authors.forename: D
authors.initials: D
authors.lastname: Papakosta
authors.forename: G
authors.initials: G
authors.lastname: Pitsiou
authors.forename: Z
authors.initials: Z
authors.lastname: Daniil
authors.forename: M
authors.initials: M
authors.lastname: Dimadi
authors.forename: E
authors.initials: E
authors.lastname: Stagaki
authors.forename: A
authors.initials: A
authors.lastname: Rapti
authors.forename: K
authors.initials: K
authors.lastname: Antoniou
authors.forename: A
authors.initials: A
authors.lastname: Tzouvelekis
authors.forename: T
authors.initials: T
authors.lastname: Kontakiotis
authors.forename: S
authors.initials: S
authors.lastname: Tryfon
authors.forename: V
authors.initials: V
authors.lastname: Polychronopoulos
authors.forename: D
authors.initials: D
authors.lastname: Bouros
mesh_terms: D000368:Aged; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005080:Exercise Test; D065627:Familial Primary Pulmonary Hypertension; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D054990:Idiopathic Pulmonary Fibrosis / Q000453:epidemiology*; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010100:Oxygen / Q000097:blood; D015995:Prevalence; D011446:Prospective Studies; D012129:Respiratory Function Tests; D016138:Walking / Q000502:physiology
chemical_list: D020097:Natriuretic Peptide, Brain; D010100:Oxygen