title: A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps.
abstract: Meta-analyses are essential to summarize the results of the growing number of neuroimaging studies in psychiatry, neurology and allied disciplines. Image-based meta-analyses use full image information (i.e. the statistical parametric maps) and well-established statistics, but images are rarely available making them highly unfeasible. Peak-probability meta-analyses such as activation likelihood estimation (ALE) or multilevel kernel density analysis (MKDA) are more feasible as they only need reported peak coordinates. Signed-differences methods, such as signed differential mapping (SDM) build upon the positive features of existing peak-probability methods and enable meta-analyses of studies comparing patients with controls. In this paper we present a new version of SDM, named Effect Size SDM (ES-SDM), which enables the combination of statistical parametric maps and peak coordinates and uses well-established statistics. We validated the new method by comparing the results of an ES-SDM meta-analysis of studies on the brain response to fearful faces with the results of a pooled analysis of the original individual data. The results showed that ES-SDM is a valid and reliable coordinate-based method, whose performance might be additionally increased by including statistical parametric maps. We anticipate that ES-SDM will be a helpful tool for researchers in the fields of psychiatry, neurology and allied disciplines.
authors.affiliation: Department of psychosis Studies, institute of psychiatry, King's College London, P.O. 69, London, SE5 8AF, UK. Joaquim.Radua@iop.kcl.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Radua
authors.forename: D
authors.initials: D
authors.lastname: Mataix-Cols
authors.forename: M L
authors.initials: ML
authors.lastname: Phillips
authors.forename: W
authors.initials: W
authors.lastname: El-Hage
authors.forename: D M
authors.initials: DM
authors.lastname: Kronhaus
authors.forename: N
authors.initials: N
authors.lastname: Cardoner
authors.forename: S
authors.initials: S
authors.lastname: Surguladze
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods* / Q000706:statistics & numerical data; D005149:Facial Expression; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D059906:Neuroimaging / Q000379:methods* / Q000706:statistics & numerical data; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D015203:Reproducibility of Results