title: Radioimmunoscintigraphy of colorectal carcinomas with 99mTc-labelled antibodies.
abstract: OBJECTIVE
  The aim of the study was the evaluation of the clinical validity of immunoscintigraphy with 99mTc labeled antibodies for the detection of metastases and recurrences of colorectal carcinomas.
  
  
  METHODS
  We examined 17 patients with colorectal carcinomas. Scintigraphy was performed with anti-CEA MoAb 99mTc-BW 431/26.
  
  
  RESULTS
  Recurrences of carcinomas were detected and confirmed by surgery in 6 patients, recurrences with liver metastasis in 5 patients, and only liver metastases in 3 patients. Planar immunoscintigraphy was positive in 5/8 patients with liver metastases and 8/11 patients with recurrences, whereas in 1/8 liver metastases and 3/11 recurrences were detected only by tomography. In two patients with metastases in the abdominal lymph nodes immunoscintigraphic findings both on planar scintigraphy and tomoscintigraphy were false negative.
  
  
  CONCLUSIONS
  Immunoscintigraphy with 99mTc labeled antibodies can be useful in the diagnosis of recurrences and metastases of colorectal carcinoma, viability assessment after radiotherapy and in the choice of the adequate surgical treatment.
authors.affiliation: Center for Nuclear Medicine, Clinical Center of Serbia, School of Medicine, University of Belgrade, Serbia. veraart@beotel.rs
authors.forename: Vera
authors.initials: V
authors.lastname: Artiko
authors.forename: Milorad
authors.initials: M
authors.lastname: Petrović
authors.forename: Dragana
authors.initials: D
authors.lastname: Sobić-Saranović
authors.forename: Andrija
authors.initials: A
authors.lastname: Antić
authors.forename: Ana
authors.initials: A
authors.lastname: Koljević-Marković
authors.forename: Emilija
authors.initials: E
authors.lastname: Krajnović-Jaksić
authors.forename: Djordjije
authors.initials: D
authors.lastname: Saranović
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Petrović
authors.forename: Mirjana
authors.initials: M
authors.lastname: Stojković
authors.forename: Darija
authors.initials: D
authors.lastname: Durutović
authors.forename: Marinko
authors.initials: M
authors.lastname: Zuvela
authors.forename: Anica
authors.initials: A
authors.lastname: Radovanović-Bobić
authors.forename: Danijel
authors.initials: D
authors.lastname: Galun
authors.forename: Zorica
authors.initials: Z
authors.lastname: Petrasinović
authors.forename: Smiljana
authors.initials: S
authors.lastname: Pavlović
authors.forename: Zoran
authors.initials: Z
authors.lastname: Krivokapić
authors.forename: Vladimir
authors.initials: V
authors.lastname: Obradović
mesh_terms: D002272:Carcinoembryonic Antigen / Q000097:blood / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D016719:Radioimmunodetection; D013667:Technetium; D014057:Tomography, X-Ray Computed
chemical_list: D002272:Carcinoembryonic Antigen; D013667:Technetium