title: Transformation of follicular lymphoma.
abstract: Histological transformation of follicular lymphoma (FL) to a more aggressive non-Hodgkin's lymphomas is a pivotal event in the natural history of FL and is associated with poor outcome. While commonly observed in clinical practice and despite multiple studies designed to address its pathogenesis, the biology of this process represents an enigma. In this chapter we present a state of the art review summarizing the definition of histologic transformation, its incidence, pathogenesis, clinical manifestations, treatment and outcome. Furthermore, we specifically emphasize gaps in our knowledge that should be addressed in future studies.
authors.affiliation: Department of Medicine & Division of Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami, 1475NW 12th Ave, D8-4, Miami, FL 33136, USA. Ilossos@med.miami.edu
authors.forename: Izidore S
authors.initials: IS
authors.lastname: Lossos
authors.forename: Randy D
authors.initials: RD
authors.lastname: Gascoyne
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000096:biosynthesis; D001706:Biopsy; D002051:Burkitt Lymphoma / Q000209:etiology / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology*; D002869:Chromosome Aberrations; D018450:Disease Progression; D018572:Disease-Free Survival; D006801:Humans; D008224:Lymphoma, Follicular / Q000150:complications / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D009154:Mutation; D011379:Prognosis; D016879:Salvage Therapy; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous
chemical_list: D014408:Biomarkers, Tumor