title: Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms.
abstract: The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.
authors.affiliation: Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Juliane Maries Vej 22, DK-2100 Copenhagen, Denmark.
authors.forename: Wang
authors.initials: W
authors.lastname: Hengzhuang
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.forename: Oana
authors.initials: O
authors.lastname: Ciofu
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Song
authors.forename: Niels
authors.initials: N
authors.lastname: Høiby
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D003091:Colistin / Q000493:pharmacokinetics / Q000494:pharmacology*; D015378:Imipenem / Q000493:pharmacokinetics / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem; D003091:Colistin