title: Anti-resorptive activity and pharmacokinetic study of N(1),N(1)-diisopropyl-N(2)-(diphenylphosphoryl)-2-(4-nitrophenyl)acetamidine.
abstract: In vitro anti-resorptive activity, mechanism of action, pharmacokinetic profile and in vivo anti-resorptive activity of N(1),N(1)-diisopropyl-N(2)-(diphenylphosphoryl)-2-(4-nitrophenyl)acetamidine (1) were evaluated.
authors.affiliation: Laboratory of Chemical Genomics, Bio-Organic Science Division, Korea Research Institute of Chemical Technology, Sinseongno 19, Yuseong-gu, Daejeon 305-600, Republic of Korea.
authors.forename: Myung Hee
authors.initials: MH
authors.lastname: Kim
authors.forename: Mikyung
authors.initials: M
authors.lastname: Park
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Song
authors.forename: Sang-Joon
authors.initials: SJ
authors.lastname: Park
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000284:Administration, Oral; D000578:Amidines / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D050071:Bone Density Conservation Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D045744:Cell Line, Tumor; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051379:Mice; D010755:Organophosphates / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D053245:RANK Ligand / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000578:Amidines; D050071:Bone Density Conservation Agents; C561925:N1,N1-diisopropyl-N2-(diphenylphosphoryl)-2-(4-nitrophenyl)acetamidine; D010755:Organophosphates; D053245:RANK Ligand