title: Biological feasibility of measles eradication.
abstract: Recent progress in reducing global measles mortality has renewed interest in measles eradication. Three biological criteria are deemed important for disease eradication: (1) humans are the sole pathogen reservoir; (2) accurate diagnostic tests exist; and (3) an effective, practical intervention is available at reasonable cost. Interruption of transmission in large geographical areas for prolonged periods further supports the feasibility of eradication. Measles is thought by many experts to meet these criteria: no nonhuman reservoir is known to exist, accurate diagnostic tests are available, and attenuated measles vaccines are effective and immunogenic. Measles has been eliminated in large geographical areas, including the Americas. Measles eradication is biologically feasible. The challenges for measles eradication will be logistical, political, and financial.
authors.affiliation: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA. wmoss@jhsph.edu
authors.forename: William J
authors.initials: WJ
authors.lastname: Moss
authors.forename: Peter
authors.initials: P
authors.lastname: Strebel
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D004197:Disease Reservoirs / Q000821:virology; D004198:Disease Susceptibility; D014644:Genetic Variation; D014943:Global Health; D015658:HIV Infections / Q000150:complications / Q000276:immunology; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007223:Infant; D008457:Measles / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D008458:Measles Vaccine / Q000276:immunology; D008459:Measles virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D011159:Population Surveillance; D018419:Primate Diseases / Q000276:immunology / Q000821:virology; D011323:Primates; D012367:RNA, Viral / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine; D012367:RNA, Viral