title: Central nervous system involvement in diabetic neuropathy.
abstract: Diabetic neuropathy is a chronic and often disabling condition that affects a significant number of individuals with diabetes. Long considered a disease of the peripheral nervous system, there is now increasing evidence of central nervous system involvement. Recent advances in neuroimaging methods detailed in this review have led to a better understanding and refinement of how diabetic neuropathy affects the central nervous system. Recognition that diabetic neuropathy is, in part, a disease that affects the whole nervous system is resulting in a critical rethinking of this disorder, opening a new direction for further research.
authors.affiliation: Diabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Selvarajah
authors.forename: Iain D
authors.initials: ID
authors.lastname: Wilkinson
authors.forename: Jennifer
authors.initials: J
authors.lastname: Davies
authors.forename: Rajiv
authors.initials: R
authors.lastname: Gandhi
authors.forename: Solomon
authors.initials: S
authors.lastname: Tesfaye
mesh_terms: D002490:Central Nervous System / Q000473:pathology / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology