title: Cu-mediated chemoselective trifluoromethylation of benzyl bromides using shelf-stable electrophilic trifluoromethylating reagents.
abstract: Copper-mediated chemoselective trifluoromethylation at the benzylic position by the use of shelf-stable electrophilic trifluoromethylating reagents 3 in good to high yields under mild conditions is described for the first time. The generality of this trifluoromethylation for a wide variety of benzyl bromides facilitates the rapid creation of structural diversity of medicinal candidates in drug discovery.
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Nagoya 466-8555, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawai
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Furukawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nomura
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tokunaga
authors.forename: Norio
authors.initials: N
authors.lastname: Shibata
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D055808:Drug Discovery; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001593:Benzyl Compounds; D006846:Hydrocarbons, Halogenated; D003300:Copper; C038682:benzyl bromide