title: [Evaluations of poly(methyl methacrylate) bearing glucose pendant or cellobiose pendant in high performance liquid chromatography as polymeric chiral stationary phases].
abstract: The glucopyranos units consisting of cyclodextrin and polysaccharide derivatives have been extensively used as chromatographic chiral stationary phases. The synthetic polymeric chiral stationary phases based on methyl methacrylate bearing glucose or cellobiose pendants for high performance liquid chromatography (HPLC) were prepared by radical polymerization. Fifteen racemic chiral compounds including alcohols, amines, amides and ketones, were resolved on the two chiral stationary phases using hexane-isopropanol (90/10, v/v), hexane-isopropanol-triethylamine (90/10/0.2, v/v/v) or hexane-isopropanol-trifluoroacetic acid (90/ 10/0.2, v/v/v) as mobile phase, separately. The results showed that both chiral stationary phases possessed good enantioselectivity for most of the racemic alcohols and amines. A few amides and ketones could also be separated. There was some compensation of the chiral discriminating abilities between the two chiral stationary phases. This work indicates that polymers of mono- and disaccharide derivatives can soon become a very attractive new chiral stationary phase for HPLC.
authors.affiliation: College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Ye
authors.forename: Lanfen
authors.initials: L
authors.lastname: Yang
authors.forename: Ya
authors.initials: Y
authors.lastname: Peng
authors.forename: Xuexian
authors.initials: X
authors.lastname: Chen
authors.forename: Liming
authors.initials: L
authors.lastname: Yuan
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002475:Cellobiose / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D005947:Glucose / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000588:Amines; D011108:Polymers; D002475:Cellobiose; D019904:Polymethyl Methacrylate; D005947:Glucose