title: Association of the metabolic syndrome with age-related, nonatherosclerotic, chronic medical conditions.
abstract: Abstract In this article we review the association of three principal factors of the metabolic syndrome-- insulin resistance, hypertension, and increased levels of inflammation factors--with several chronic, nonatherosclerotic conditions associated with aging--frailty, cognitive decline, impaired cardiovascular autonomic control, and possibly osteoporosis. We hypothesize that the metabolic syndrome is associated with "accelerated" aging.
authors.affiliation: Kaiser Permanente of Georgia and the Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Joshua I
authors.initials: JI
authors.lastname: Barzilay
authors.forename: Phyllis K
authors.initials: PK
authors.lastname: Stein
mesh_terms: D050154:Adiposity; D000367:Age Factors; D000368:Aged; D000375:Aging; D050197:Atherosclerosis / Q000150:complications*; D002318:Cardiovascular Diseases / Q000150:complications; D002908:Chronic Disease; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D010024:Osteoporosis / Q000150:complications