title: Periocular changes following long-term administration of latanoprost 0.005%.
abstract: This is a case series of 3 patients who presented with periocular changes in the treated eye following chronic administration of unilateral latanoprost 0.005%. The clinical changes included worsening of dermatochalasis, deepening of superior sulcus and hollowness of the lid. This similar observation was previously described in usage of bimatoprost 0.03% and travoprost 0.004%. However this has not been reported in latanoprost instillation. Therefore, patients should be made aware of these potential side effects.
authors.affiliation: Eye Department, Royal Hallamshire Hospital, Sheffield, United Kingdom. ctu195@yahoo.co.uk
authors.forename: Tsiang
authors.initials: T
authors.lastname: Ung
authors.forename: Zanna I
authors.initials: ZI
authors.lastname: Currie
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015841:Enophthalmos / Q000139:chemically induced; D005141:Eyelid Diseases / Q000139:chemically induced*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D000077338:Latanoprost; D008297:Male; D009798:Ocular Hypertension / Q000188:drug therapy; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000009:adverse effects*; D015595:Skin Aging / Q000187:drug effects; D012871:Skin Diseases / Q000139:chemically induced*; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost