title: Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy.
abstract: Copper deficiency in humans can result in both anaemia and neurological symptoms affecting walking and balance. Recently zinc excess due to overuse of zinc-containing denture adhesive has been recognised as a potential cause of copper deficiency. Recovery from neurological symptoms with replacement therapy appears to be limited and so emphasis falls on education and early detection. Dentists are well placed to educate patients on use of denture adhesives and to detect early signs of copper deficiency in patients who may be using zinc-containing denture adhesive to excess. A case of a 58-year-old man diagnosed with copper deficiency myelopathy possibly due to zinc-containing denture cream overuse is presented.
authors.affiliation: School of Medicine, University of St Andrews, Medical and Biological Sciences Building, North Haugh, St Andrews, KY16 9TF. kb_doherty@hotmail.com
authors.forename: K
authors.initials: K
authors.lastname: Doherty
authors.forename: M
authors.initials: M
authors.lastname: Connor
authors.forename: R
authors.initials: R
authors.lastname: Cruickshank
mesh_terms: D000269:Adhesives / Q000009:adverse effects / Q000737:chemistry*; D000748:Anemia, Macrocytic / Q000209:etiology; D003300:Copper / Q000172:deficiency* / Q000378:metabolism; D003781:Denture Retention; D006801:Humans; D008297:Male; D008668:Metallothionein / Q000378:metabolism; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D010292:Paresthesia / Q000209:etiology; D013118:Spinal Cord Diseases / Q000209:etiology*; D015032:Zinc / Q000009:adverse effects* / Q000378:metabolism
chemical_list: D000269:Adhesives; D003300:Copper; D008668:Metallothionein; D015032:Zinc