title: Waking up dormant tumors.
abstract: As appreciation grows for the contribution of the tumor microenvironment to the progression of cancer, new evidence accumulates to support that the participation of stromal cells can extend beyond the local environment. Recently, Elkabets and colleagues demonstrated a systemic interaction between cancer cells and distant bone marrow cells to support the growth of otherwise indolent tumor cells at a secondary site, raising thought-provoking questions regarding the involvement of stromal cells in maintaining metastatic dormancy.
authors.affiliation: Harvard Medical School, Boston, MA 02115, USA. jtse@bidmc.harvard.edu
authors.forename: Joyce C
authors.initials: JC
authors.lastname: Tse
authors.forename: Raghu
authors.initials: R
authors.lastname: Kalluri
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D051379:Mice; D053495:Osteopontin / Q000378:metabolism; D000077153:Progranulins; D017154:Stromal Cells; D059016:Tumor Microenvironment
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins; D053495:Osteopontin