title: Biodistribution and biocompatibility of DMSA-stabilized maghemite magnetic nanoparticles in nonhuman primates (Cebus spp.).
abstract: OBJECTIVE
  This work represents the first reported investigation on the effects of magnetic nanoparticles (MNPs) in nonhuman primates. Biodistribution, biocompatibility and nanotoxicity of maghemite nanoparticles stabilized with dimercaptosuccinic acid (DMSA) were accessed.
  
  
  METHODS
  A control animal was used and three other animals were intravenously injected with DMSA-MNPs and euthanized 12 h, 30 and 90 days following administration. Extracted organs were processed by histological techniques. An additional animal was used to collect blood samples to complementarily assess biocompatibility 12 h, 7, 15, 30, 60 and 90 days after DMSA-MNP injection.
  
  
  RESULTS
  DMSA-MNPs were preferentially addressed to the lungs, liver and kidneys. Hematological and serum biochemical results corroborated histological findings, supporting DMSA-MNP biocompatibility while preserving both hepatic and renal normal activity.
  
  
  CONCLUSIONS
  DMSA-MNPs were preferentially distributed to the lung, liver and kidneys. Furthermore, DMSA-MNPs were considered biocompatible, supporting their application as a promising nanomaterial platform for future biomedical use.
authors.affiliation: University of Brasilia, Brasilia, DF, 70910-70900, Brazil.
authors.forename: Victoria
authors.initials: V
authors.lastname: Monge-Fuentes
authors.forename: Monica Pereira
authors.initials: MP
authors.lastname: Garcia
authors.forename: Maria Clotilde Henriques
authors.initials: MC
authors.lastname: Tavares
authors.forename: Caroline R A
authors.initials: CR
authors.lastname: Valois
authors.forename: Emilia C D
authors.initials: EC
authors.lastname: Lima
authors.forename: Danilo Simonini
authors.initials: DS
authors.lastname: Teixeira
authors.forename: Paulo C Sar
authors.initials: PC
authors.lastname: Morais
authors.forename: Carlos
authors.initials: C
authors.lastname: Tomaz
authors.forename: Ricardo Bentes
authors.initials: RB
authors.lastname: Azevedo
mesh_terms: D000818:Animals; D000882:Haplorhini; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry* / Q000648:ultrastructure; D004113:Succimer / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics*
chemical_list: D004113:Succimer