title: Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.
abstract: Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.
authors.affiliation: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Tkach
authors.forename: Galina V
authors.initials: GV
authors.lastname: Shurin
authors.forename: Michael R
authors.initials: MR
authors.lastname: Shurin
authors.forename: Elena R
authors.initials: ER
authors.lastname: Kisin
authors.forename: Ashley R
authors.initials: AR
authors.lastname: Murray
authors.forename: Shih-Houng
authors.initials: SH
authors.lastname: Young
authors.forename: Alexander
authors.initials: A
authors.lastname: Star
authors.forename: Bengt
authors.initials: B
authors.lastname: Fadeel
authors.forename: Valerian E
authors.initials: VE
authors.lastname: Kagan
authors.forename: Anna A
authors.initials: AA
authors.lastname: Shvedova
mesh_terms: D000818:Animals; D002452:Cell Count; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology*; D005260:Female; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008168:Lung / Q000187:drug effects* / Q000276:immunology*; D051379:Mice; D037742:Nanotubes, Carbon / Q000009:adverse effects*; D010614:Pharynx / Q000187:drug effects; D011014:Pneumonia / Q000139:chemically induced / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D037742:Nanotubes, Carbon