title: Development of miracle medicines from sialic acids.
abstract: Sialic acids are electronegatively charged C9-sugars and are considered to play important roles in higher animals and some microorganisms. Denoting their significance, understanding and exploiting the complexity of the sialic acids has been referred to as the "the third language of life". In essence, "sialic acid derivatives possess a harmonious shape and good balance between two opposing hydrophilic and hydrophobic parts, meaning that they should display various kinds of potentially unique and possibly conflicting physiological activities (glycolipoids)". Consequently, there are good omens that unprecedented 'miracle' medicines could be developed from sialic acid derivatives. In this review, the first problem, the preparation of sialic acids, is covered, the synthesis of sialic acid derivatives and confirmation of their structures obviously being of critical significance. In addition we needed to confirm their precise stereochemistry and a hydrolysis method has been developed for confirmation of the anomeric position. Several of the compounds have already demonstrated interesting bioactivity.
authors.affiliation: Kitasato University, Tokyo, Japan. ogura@juno.ocn.ne.jp
authors.forename: Haruo
authors.initials: H
authors.lastname: Ogura
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D019158:N-Acetylneuraminic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D013237:Stereoisomerism
chemical_list: D004791:Enzyme Inhibitors; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid