title: Heat shock protein-60 expression was significantly correlated with the prognosis of lung adenocarcinoma.
abstract: BACKGROUND
  The purpose of this study was to investigate the role of heat shock protein 60 (HSP60) in the clinical pathology of lung adenocarcinoma, and to explore whether the expression of HSP60 can act as an independent predictor for tumor relapse and prognosis after radical resection of lung adenocarcinoma.
  
  
  METHODS
  Paraffin sections of lung adenocarcinoma tumor tissues were collected from 103 patients. Using immunohistochemistry, the expression levels of HSP60 in lung adenocarcinoma were detected. The correlations between HSP60 expression and clinicopathological parameters as well as prognosis were statistically analyzed.
  
  
  RESULTS
  Of the 103 specimens, 70 cases (68.0%) showed a strongly positive expression of HSP60, five cases (4.8%) showed a negative expression, and 28 cases (27.2%) showed a weakly positive expression. The level of HSP60 expression was significantly correlated with TNM stage of the tumor (P = 0.015), and Eastern Cooperative Oncology Group (ECOG) performance status (P = 0.027). Multivariate statistical analysis showed that patient age, pathological T stage, N stage, and HSP60 expression were independent prognostic influence on disease-free survival (P = 0.008, 0.011, 0.010, and <0.001, respectively).
  
  
  CONCLUSIONS
  HSP60 may be a good biomarker to be applied in clinic to predict the prognosis of patients with lung adenocarcinoma.
authors.affiliation: Guangdong Cardiovascular Institute, Southern Medical University, Guangdong, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Wenlong
authors.initials: W
authors.lastname: Shao
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Yin
authors.forename: Hanzhang
authors.initials: H
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Qiu
authors.forename: Mingcong
authors.initials: M
authors.lastname: Mo
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.forename: Qiuhua
authors.initials: Q
authors.lastname: Deng
authors.forename: Jianxing
authors.initials: J
authors.lastname: He
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D000368:Aged; D018834:Chaperonin 60 / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D011379:Prognosis; D015996:Survival Rate
chemical_list: D018834:Chaperonin 60