title: PET-CT in the staging and treatment of non-small-cell lung cancer.
abstract: Positron emission tomography with 2-((18)F)-fluoro- 2-deoxy-D-glucose (FDG-PET) is a metabolic imaging technique. FDG-PET is more accurate than CT for the evaluation of mediastinal involvement in patients with nonsmall- cell lung cancer, offering a high negative predictive value. It can detect occult metastases in 11% of patients, although the etiology of the extrathoracic isolated uptakes needs confirmation. Theoretically, FDG-PET can influence the planning volume for radiotherapy, primarily in patients with atelectasis. Quantification of metabolic activity using FDG-PET is influenced by the size of the lesion, glucose levels and the time elapsed since the isotope injection. More clinical trials are required to standardize the methods for performing PET, assess its use as a prognostic factor and for the evaluation of treatment response.
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ibeas
authors.forename: Blanca
authors.initials: B
authors.lastname: Cantos
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Gasent
authors.forename: Begoña
authors.initials: B
authors.lastname: Rodríguez
authors.forename: Mariano
authors.initials: M
authors.lastname: Provencio
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D002986:Clinical Trials as Topic; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18