title: Open fetal surgery for myelomeningocele.
abstract: Despite efforts at prevention through the use of preconception folic acid, spina bifida remains one of the most common congenital anomalies of the central nervous system that is compatible with life. It is, however, associated with a significant degree of lifelong morbidity. The development of open fetal surgery for myelomeningocele (MMC) has been a long process but one that serves as a model for how new procedures and technologies need to be properly evaluated before being brought into mainstream medical practice. Even so, risks and benefits need to be evaluated for each patient. The currently available studies have been carried out on a highly selected patient population where the fetal findings provided the maximum opportunity for benefit from prenatal closure of the MMC defect. There is the potential that as the surgery becomes more widely available, pressure will be brought to bear to perform surgery in cases where the likelihood for benefit is decreased and yet the risks are not. The only way to duplicate the results of the current studies is to follow the methodology and criteria that were used in the studies. This will mean that not every fetus with an MMC will be a candidate for in utero surgery. The balance of risk to benefit will continue to evolve as further technological advances are evaluated and more follow-up information is obtained.
authors.affiliation: Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA, USA. bebbington@email.chop.edu
authors.forename: Michael W
authors.initials: MW
authors.lastname: Bebbington
authors.forename: Enrico
authors.initials: E
authors.lastname: Danzer
authors.forename: Mark P
authors.initials: MP
authors.lastname: Johnson
authors.forename: N Scott
authors.initials: NS
authors.lastname: Adzick
mesh_terms: D000818:Animals; D017281:Cost of Illness; D004195:Disease Models, Animal; D005260:Female; D005332:Fetoscopy / Q000379:methods*; D006801:Humans; D008591:Meningomyelocele / Q000175:diagnosis / Q000601:surgery*; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome