title: [Vasopressin: molecular mechanisms of antidiuretic effect].
abstract: Body water balance is regulated by vasopressin, and multiple studies now have revealed essential role of aquaporins in this process. This review summarizes recent advances related to molecular events underlying the short-term control of water permeability which occurs via vesicular trafficking of AQP2 to the cell apical membrane, and long-term control through changes in the gene expression and the abundance of AQP-2, -3 and -4. The action of vasopressin on water permeability is counterbalanced by several factors such as prostaglandin E2, bradykinin, dopamin, endotelin-1 and others. Changes in AQP-2 expression / trafficking are of particular importance in pathological conditions characterized by both diluting and concentration defect of renal function.
authors.forename: L N
authors.initials: LN
authors.lastname: Ivanova
mesh_terms: D000818:Animals; D020346:Aquaporins / Q000378:metabolism / Q000502:physiology; D001834:Body Water / Q000378:metabolism; D002463:Cell Membrane Permeability; D004231:Diuresis / Q000502:physiology*; D006801:Humans; D007685:Kidney Tubules, Collecting / Q000378:metabolism / Q000502:physiology*; D021381:Protein Transport; D014667:Vasopressins / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D020346:Aquaporins; D014667:Vasopressins