title: Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage forms.
abstract: Thermogravimetry/derivative thermogravimetry (TG/DTG) and differential scanning calorimetry (DSC) techniques were used for assessing the compatibility between ketoprofen (KT) and several excipients as: corn starch, microcrystalline cellulose (PH 101 and PH 102), colloidal silicon dioxide, lactose (monohydrate and anhydre), polyvinylpyrrolidone K30, magnesium stearate and talc, commonly used in the pharmaceutical form. In order to investigate the possible interactions between the components, the thermal curves of KT and each selected excipients were compared with those of their 1:1 (w/w) physical mixtures. For KT, the DSC curves have shown a sharp endothermic peak at 96.8 °C which corresponds to the melting process (literature value: 94-97 °C), respectively the TG curves demonstrated a simple stage of mass loss in the temperature range of 235-400 °C. FT-IR spectroscopy and X-ray powder diffraction (XRPD) were used as complementary techniques to adequately implement and assist in interpretation of the DSC results. On the basis of thermal results, a possible interaction was found between the KT with polyvinylpyrrolidone K30 and magnesium stearate, which could influence the stability of the KT in the binary mixtures. These possible incompatibilities were confirmed by FT-IR and X-ray analysis.
authors.affiliation: University of Medicine and Pharmacy "Victor Babeş", Faculty of Pharmacy, Eftimie Murgu Square 2, Timişoara 300041, Romania.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Tiţa
authors.forename: Adriana
authors.initials: A
authors.lastname: Fuliaş
authors.forename: Geza
authors.initials: G
authors.lastname: Bandur
authors.forename: Eleonora
authors.initials: E
authors.lastname: Marian
authors.forename: Dumitru
authors.initials: D
authors.lastname: Tiţa
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D004304:Dosage Forms; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry*; D007660:Ketoprofen / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D033362:Powder Diffraction; D017550:Spectroscopy, Fourier Transform Infrared; D013229:Stearic Acids / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004304:Dosage Forms; D005079:Excipients; D013229:Stearic Acids; C031183:stearic acid; D007660:Ketoprofen; D011205:Povidone