title: Osteoimmunopathology in HIV/AIDS: A Translational Evidence-Based Perspective.
abstract: Infection with the human immunodeficiency virus-1 (HIV) and the resulting acquired immune deficiency syndrome (AIDS) alter not only cellular immune regulation but also the bone metabolism. Since cellular immunity and bone metabolism are intimately intertwined in the osteoimmune network, it is to be expected that bone metabolism is also affected in patients with HIV/AIDS. The concerted evidence points convincingly toward impaired activity of osteoblasts and increased activity of osteoclasts in patients with HIV/AIDS, leading to a significant increase in the prevalence of osteoporosis. Research attributes these outcomes in part at least to the ART, PI, and HAART therapies endured by these patients. We review and discuss these lines of evidence from the perspective of translational clinically relevant complex systematic reviews for comparative effectiveness analysis and evidence-based intervention on a global scale.
authors.affiliation: Section of Oral Biology, Division of Oral Biology & Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA.
authors.forename: André
authors.initials: A
authors.lastname: Barkhordarian
authors.forename: Reem
authors.initials: R
authors.lastname: Ajaj
authors.forename: Manisha H
authors.initials: MH
authors.lastname: Ramchandani
authors.forename: Gary
authors.initials: G
authors.lastname: Demerjian
authors.forename: Riana
authors.initials: R
authors.lastname: Cayabyab
authors.forename: Sohrab
authors.initials: S
authors.lastname: Danaie
authors.forename: Nora
authors.initials: N
authors.lastname: Ghodousi
authors.forename: Natasha
authors.initials: N
authors.lastname: Iyer
authors.forename: Nicole
authors.initials: N
authors.lastname: Mahanian
authors.forename: Linda
authors.initials: L
authors.lastname: Phi
authors.forename: Amy
authors.initials: A
authors.lastname: Giroux
authors.forename: Ercolano
authors.initials: E
authors.lastname: Manfrini
authors.forename: Negoita
authors.initials: N
authors.lastname: Neagos
authors.forename: Muniza
authors.initials: M
authors.lastname: Siddiqui
authors.forename: Olivia S
authors.initials: OS
authors.lastname: Cajulis
authors.forename: Xenia M C
authors.initials: XM
authors.lastname: Brant
authors.forename: Paul
authors.initials: P
authors.lastname: Shapshak
authors.forename: Francesco
authors.initials: F
authors.lastname: Chiappelli