title: Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells.
abstract: Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2 μM) and/or valproic acid (5 mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.
authors.affiliation: Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Yoshikane
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: Yotaro
authors.initials: Y
authors.lastname: Izumi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Asakura
authors.forename: Toshinori
authors.initials: T
authors.lastname: Fukutomi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Serizawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawai
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Wakui
authors.forename: Makoto
authors.initials: M
authors.lastname: Suematsu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nomori
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D001343:Autophagy; D045744:Cell Line, Tumor; D004357:Drug Synergism; D006801:Humans; D008148:Lovastatin / Q000008:administration & dosage*; D008654:Mesothelioma / Q000188:drug therapy* / Q000473:pathology; D009361:Neoplasm Invasiveness; D054363:Solitary Fibrous Tumor, Pleural / Q000188:drug therapy* / Q000473:pathology; D014635:Valproic Acid / Q000008:administration & dosage*
chemical_list: D014635:Valproic Acid; D008148:Lovastatin