title: Intestinal homeostasis and its breakdown in inflammatory bowel disease.
abstract: Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found in inflammatory bowel disease. It is now evident that immune effector modules that drive intestinal inflammation are conserved across innate and adaptive leukocytes and can be controlled by host regulatory cells. Recent evidence suggests that several factors may tip the balance between homeostasis and intestinal inflammation, presenting future challenges for the development of new therapies for inflammatory bowel disease.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. kevin.maloy@path.ox.ac.uk
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Maloy
authors.forename: Fiona
authors.initials: F
authors.lastname: Powrie
mesh_terms: D000818:Animals; D001343:Autophagy; D004848:Epithelium / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology*; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D007422:Intestines / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D008954:Models, Biological; D051192:Receptors, Pattern Recognition / Q000378:metabolism
chemical_list: D051192:Receptors, Pattern Recognition