title: Retinoblastoma with autoinfarction presenting as orbital cellulitis.
abstract: We describe a case of unilateral retinoblastoma in a 13-month-old boy who presented with signs of orbital cellulitis. Heterochromia, hyphema, and vitreous hemorrhage were observed. Initial computed tomography (CT) imaging failed to reveal the calcified intraocular mass that was later identified on ultrasonography. Histopathology of the enucleated eye revealed diffuse inflammation and tumor necrosis but with absence of malignant retinoblastoma cells. Genetic testing was equivocal. The patient is presumed to have had retinoblastoma that underwent autoinfarction, leading to secondary inflammation. This case highlights the importance of complete ocular evaluation and proper imaging modalities in children presenting with orbital cellulitis.
authors.affiliation: Cleveland Clinic, Cole Eye Institute, Cleveland, Ohio 44124, USA.
authors.forename: Reecha
authors.initials: R
authors.lastname: Sachdeva
authors.forename: Lynn
authors.initials: L
authors.lastname: Schoenfield
authors.forename: Andreas
authors.initials: A
authors.lastname: Marcotty
authors.forename: Arun D
authors.initials: AD
authors.lastname: Singh
mesh_terms: D015353:Eye Enucleation; D006801:Humans; D007223:Infant; D007238:Infarction / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D054517:Orbital Cellulitis / Q000175:diagnosis*; D019572:Retinal Neoplasms / Q000175:diagnosis*; D012171:Retinal Vessels / Q000473:pathology*; D012175:Retinoblastoma / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography