title: Cysteine proteases as potential antigens in antiparasitic DNA vaccines.
abstract: Cysteine proteases in parasites are potent inducers of vertebrate host immune responses and may under certain circumstances take part in the pathogen's immune evasion strategies. These capacities place these parasite molecules as interesting candidate antigens in antiparasitic vaccines for use in vertebrates. Parasite cysteine proteases are able to skew the Th1/Th2 profile in mammals towards a response which allows sustainable parasite burdens in the host. DNA vaccines are also able to skew the Th1/Th2 profile by different administration techniques and the use of cysteine proteases in these genetic immunizations open perspectives for manipulation of the host immune response towards higher protection.
authors.affiliation: Laboratory of Aquatic Pathobiology, Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Denmark. lgj@life.ku.dk
authors.forename: Louise von Gersdorff
authors.initials: Lv
authors.lastname: Jørgensen
authors.forename: Kurt
authors.initials: K
authors.lastname: Buchmann
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents; D057056:Cysteine Proteases / Q000276:immunology*; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D010272:Parasitic Diseases / Q000276:immunology / Q000517:prevention & control*; D010273:Parasitic Diseases, Animal / Q000276:immunology / Q000517:prevention & control*; D058408:Th1-Th2 Balance; D014611:Vaccination; D019444:Vaccines, DNA / Q000276:immunology*
chemical_list: D000977:Antiparasitic Agents; D019444:Vaccines, DNA; D057056:Cysteine Proteases