title: Ask-Upmark kidney and tubulointerstitial nephritis in a woman with severe renal failure.
abstract: Ask-Upmark kidney is a rare diagnosis of segmental hypoplasia in pediatric population clinically characterized by severe hypertension potentially treatable with partial to total nephrectomy. Although originally was described only as a congenital anomaly, recent data suggest to be caused by vesicoureteral reflux, either in utero or in early childhood and pyelonephritis. The case we reported indicates that Ask-Upmark kidney should be considered as potential cause of hypertension and renal failure both in children and adults. The renal biopsy is necessary for early diagnosis and may consent to normalize blood pressure with nephrectomy; however, if renal damage is severe and progressive with tubulointerstitial nephritis, surgical management is excluded and renal transplant should be considered.
authors.affiliation: Department of Nephrology, Sapienza University of Rome, Rome, Italy. antonietta_gigante@yahoo.it
authors.forename: Antonietta
authors.initials: A
authors.lastname: Gigante
authors.forename: Maria Ludovica
authors.initials: ML
authors.lastname: Gasperini
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Giannakakis
authors.forename: Biagio
authors.initials: B
authors.lastname: Barbano
authors.forename: Filippo
authors.initials: F
authors.lastname: Rossi Fanelli
authors.forename: Alessia
authors.initials: A
authors.lastname: Papa
authors.forename: Rosario
authors.initials: R
authors.lastname: Cianci
authors.forename: Antonio
authors.initials: A
authors.lastname: Amoroso
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007668:Kidney / Q000002:abnormalities*; D009395:Nephritis, Interstitial / Q000209:etiology*; D051437:Renal Insufficiency / Q000209:etiology*; D012720:Severity of Illness Index