title: Constructing realistic engrams: poststimulus activity of hippocampus and dorsal striatum predicts subsequent episodic memory.
abstract: Encoding of real-life episodic memory commonly involves integration of information as the episode unfolds. Offline processing immediately following event offset is expected to play a role in encoding the episode into memory. In this study, we examined whether distinct human brain activity time-locked to the offset of short narrative audiovisual episodes could predict subsequent memory for the gist of the episodes. We found that a set of brain regions, most prominently the bilateral hippocampus and the bilateral caudate nucleus, exhibit memory-predictive activity time-locked to the stimulus offset. We propose that offline activity in these regions reflects registration to memory of integrated episodes.
authors.affiliation: Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. aya.benyakov@weizmann.ac.il
authors.forename: Aya
authors.initials: A
authors.lastname: Ben-Yakov
authors.forename: Yadin
authors.initials: Y
authors.lastname: Dudai
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001245:Association Learning / Q000502:physiology; D001931:Brain Mapping; D003342:Corpus Striatum / Q000098:blood supply / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D010100:Oxygen