title: Impulsive and compulsive behaviors in Parkinson's disease: a one-year follow-up study.
abstract: Impulsive and compulsive behaviors (ICBs) have been reported to occur frequently in Parkinson's disease (PD) and include impulse control disorders (ICDs), punding and dopamine dysregulation syndrome (SSD). We report on the outcomes of 25 PD patients who developed ICBs. Information was collected on changes in parkinsonian and psychiatric medication follow-up (median=12.1 months). At time 1, only 18 patients (72%) were taking dopamine agonists (DA). At time 2, fifteen patients (83.33%) either discontinued or decreased their DA treatment. Of these patients, thirteen (86.67%) reported experiencing full or partial remission of their ICBs symptoms. When analyzing separately the 11 patients with punding, these symptoms remained unchanged in 9 patients (81.82%) independently of changes in dopaminergic drugs. In conclusion, the current study suggests that there are clear similarities, but also important differences, between punding and ICDs over time. Pathological gambling, binge or compulsive eating, pathological hypersexuality and compulsive shopping in PD were robustly associated with the use of DA but the relationship between dopaminergic medications and punding is less clear. It is important to determine if other treatment strategies may be effective for punding in PD.
authors.affiliation: Department of Neurology, Hospital General de l'Hospitalet, Consorci Sanitari Integral, Hospitalet de Llobregat (Barcelona), Spain. asuncion.avila@sanitatintegral.org
authors.forename: Asunción
authors.initials: A
authors.lastname: Ávila
authors.forename: Xavier
authors.initials: X
authors.lastname: Cardona
authors.forename: Montse
authors.initials: M
authors.lastname: Martín-Baranera
authors.forename: Juan
authors.initials: J
authors.lastname: Bello
authors.forename: Francesc
authors.initials: F
authors.lastname: Sastre
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D003192:Compulsive Behavior / Q000188:drug therapy* / Q000209:etiology; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007175:Impulsive Behavior / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D018491:Dopamine Agonists