title: [Effect of oral scorpio and scolopendra powder on T-cell subsets in peripheral blood and intestine from rats with collagen induced arthritis].
abstract: OBJECTIVE
  To observe effect of oral scorpio and scolopendra powder on T-cell subsets in peripheral blood and intestine from rats with collagen induced arthritis (CIA).
  
  
  METHODS
  60 rats were randomly divided into 6 groups: normal control group, model control group, low-dose scorpio and scolopendra group, middle-dose scorpio and scolopendra group, high-dose scorpio and scolopendra group, and type II collagen group. Rat's rheumatoid arthritis was induced by collagen II (C II). Level of T-cell subsets from peripheral blood and intestine was measured by flow cytometry.
  
  
  RESULTS
  CD4+ T cellular level was obviously increased (P < 0.05 or P < 0.01) or kept increased tendency in peripheral blood and intestine from the model group compared with that of the normal group, while the ratio of CD4+/CD8+ in intestine was obviously descent but the contrary in peripheral blood (P < 0.05 or P < 0.01). CD4+, CD8+ T cellular level in intestine were obviously descent and the ratio of CD4+ /CD8+ increased in all treated groups when compared with in the model group (P < 0.05 or P < 0.01). However, CD4+ T cellular level and the ratio of CD4+/CD8+ in peripheral blood were remarkablely decreased.
  
  
  CONCLUSIONS
  The mechanism that scorpio and scolopendra could treat rat's rheumatoid arthritis may be regulating balance of T-lymphocyte subsets in peripheral blood and intestine.
authors.affiliation: Jiangxi University of Traditional Chinese Medicine, College of Basic Medicine, Nanchang 330006, China. chengshaomin@189.com
authors.forename: Shaomin
authors.initials: S
authors.lastname: Cheng
authors.forename: Haimei
authors.initials: H
authors.lastname: Zhao
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Zuo
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Wang
authors.forename: Yuesheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Duanyong
authors.initials: D
authors.lastname: Liu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D005260:Female; D007413:Intestinal Mucosa / Q000276:immunology*; D008516:Medicine, Chinese Traditional; D051381:Rats; D017208:Rats, Wistar; D012605:Scorpions / Q000737:chemistry*; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents