title: Drug-induced pemphigus.
abstract: Pemphigus is an autoimmune bullous disease that may be influenced by genetic and exogenous factors. Drugs are a leading cause of pemphigus. There is a need for a thorough history taking so as to find the culprit medication. The diagnosis of drug-induced pemphigus is challenging. Patients have often been exposed to multiple drugs, and some drugs may have a prolonged latency period between exposure and onset of the disease. The in vitro interferon-gamma (IFN-gamma) release from lymphocytes test has been shown to be of diagnostic value in drug-induced skin reactions. Cessation of the offending drug may alleviate the clinical manifestations and reduce the need for medical treatment.
authors.affiliation: Department of Dermatology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, 6 Weizmann Street, Tel-Aviv University, Tel Aviv 64239, Israel. i-f-skin@zahav.net.il
authors.forename: Sarah
authors.initials: S
authors.lastname: Brenner
authors.forename: Ilan
authors.initials: I
authors.lastname: Goldberg
mesh_terms: D003877:Dermatitis, Contact / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects; D010392:Pemphigus / Q000139:chemically induced* / Q000175:diagnosis*; D010636:Phenols / Q000009:adverse effects; D013438:Sulfhydryl Compounds / Q000009:adverse effects
chemical_list: D010636:Phenols; D013438:Sulfhydryl Compounds; D007371:Interferon-gamma