title: Respiratory disease and early serum S100A12 changes in very premature infants.
abstract: OBJECTIVE
  The role of granulocyte-specific S100A12, a marker for inflammatory disorders, in newborn lung disease is unknown. We compared postnatal blood S100A12 concentrations against respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD).
  
  
  METHODS
  Blood samples from 92 newborns were collected on admission, 12 h, day 1, day 3-4 and day 7, and analysed for S100A12. IL-8 and IL-6 were assayed in 52 infants.
  
  
  RESULTS
  Infants with RDS were significantly more premature (median 27 vs. 34 weeks), more likely to receive antenatal corticosteroids (84% vs. 26%) and have lower neutrophil counts (median 2.4 vs. 3.8 × 10(9) /L) at admission. S100A12 levels peaked during the first day and were significantly lower in preterm infants with RDS compared to those without (median 250 vs. 616 ng/mL at 12 h, 281 vs. 828 ng/mL day 1, respectively). S100A12 levels were low among the 35 very preterm infants (24-29 week gestation) regardless of the presence of BPD (285 vs. 288 ng/mL on day 1). In comparison, IL-8 and IL-6 levels were not different between groups.
  
  
  CONCLUSIONS
  Plasma S100A12 is low in infants with RDS, possibly because of gestationally related differences in neutrophil response or to the effects of antenatal corticosteroids. It is therefore not a useful marker of BPD development.
authors.affiliation: University of New South Wales, Sydney, NSW, Australia.
authors.forename: Alison
authors.initials: A
authors.lastname: Loughran-Fowlds
authors.forename: Steven
authors.initials: S
authors.lastname: Leach
authors.forename: Jianwei
authors.initials: J
authors.lastname: Lin
authors.forename: Julee
authors.initials: J
authors.lastname: Oei
authors.forename: Richard
authors.initials: R
authors.lastname: Henry
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Day
authors.forename: Kei
authors.initials: K
authors.lastname: Lui
mesh_terms: D015415:Biomarkers / Q000097:blood; D001997:Bronchopulmonary Dysplasia / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007958:Leukocyte Count; D016015:Logistic Models; D009504:Neutrophils; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood*; D009418:S100 Proteins / Q000097:blood / Q000502:physiology*; D000067616:S100A12 Protein
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D016209:Interleukin-8; D009418:S100 Proteins; D000067616:S100A12 Protein; C090441:S100A12 protein, human