title: Failure to reverse prolonged vecuronium-induced neuromuscular blockade with edrophonium in an anesthetized dog.
abstract: A case of prolonged muscle relaxation after vecuronium in an anesthetized dog is presented. After using peripheral nerve stimulation to confirm partial recovery of neuromuscular transmission, administration of 0.5 mg/kg IV of intravenous edrophonium failed to complete the reversal process. Subsequent administration of neostigmine resulted in complete recovery from blockade. Without monitoring neuromuscular function with a peripheral nerve stimulator until reversal was complete, it was very likely this patient would have been extubated with incomplete neuromuscular transmission. Several factors affecting the duration of neuromuscular blockade and its reversal are addressed.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
authors.forename: Manuel
authors.initials: M
authors.lastname: Martin-Flores
authors.forename: Jordyn
authors.initials: J
authors.lastname: Boesch
authors.forename: Luis
authors.initials: L
authors.lastname: Campoy
authors.forename: Robin D
authors.initials: RD
authors.lastname: Gleed
mesh_terms: D000762:Anesthesia Recovery Period; D000818:Animals; D004285:Dogs / Q000502:physiology*; D004491:Edrophonium / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009388:Neostigmine / Q000008:administration & dosage / Q000494:pharmacology*; D019148:Neuromuscular Blockade / Q000009:adverse effects / Q000662:veterinary*; D009466:Neuromuscular Blocking Agents / Q000037:antagonists & inhibitors*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D014673:Vecuronium Bromide / Q000008:administration & dosage / Q000009:adverse effects* / Q000037:antagonists & inhibitors
chemical_list: D009466:Neuromuscular Blocking Agents; D003473:Neuromuscular Nondepolarizing Agents; D009388:Neostigmine; D004491:Edrophonium; D014673:Vecuronium Bromide