title: Spontaneous amphophilic focus in the liver of a young Sprague-Dawley rat.
abstract: Altered hepatocellular focus was histopathologically observed in the liver of a 6-week-old Sprague-Dawley rat. The hepatocytes within this lesion had diffusely eosinophilic cytoplasm with scattered basophilia and slightly enlarged nuclei with prominent nucleoli. Based on these cytological characteristics, the lesion of these hepatocytes was classified as an amphophilic focus. This is the first report to describe spontaneous amphophilic focus in a young rat.
authors.affiliation: Safety Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, 1-1-1, Kazusakamatari, Kisarazu, Chiba 292-0818, Japan. sato.hiroko@mc.mt-pharma.co.jp
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sato
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sakairi
authors.forename: Shiro
authors.initials: S
authors.lastname: Takagi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kitamura
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology* / Q000662:veterinary; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology* / Q000662:veterinary; D051381:Rats; D017207:Rats, Sprague-Dawley; D012376:Rodent Diseases / Q000473:pathology*; D013449:Sulfonamides / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; C012655:nimesulide