title: Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis?
abstract: The resolution of inflammation is central to the maintenance of good health and immune homeostasis. Recently, several intracellular stress proteins have been described as having extracellular properties that are anti-inflammatory or favour the resolution of inflammation. We propose that these molecules should be defined as resolution-associated molecular patterns (RAMPs). RAMPs are released at times of cellular stress and help to counterbalance the inflammatory effects of pathogen-associated (PAMPs) and damage-associated (DAMPs) molecular patterns. We propose that heat shock protein 10 (HSP10), αB-crystallin (αBC), HSP27 and binding immunoglobulin protein (BiP) should be considered founding members of the RAMP family. A greater understanding of RAMP biology may herald the development of novel immunotherapies.
authors.affiliation: Academic Department of Rheumatology, King's College London School of Medicine at Guy's, King's and St Thomas' Hospitals, London, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Shields
authors.forename: G S
authors.initials: GS
authors.lastname: Panayi
authors.forename: V M
authors.initials: VM
authors.lastname: Corrigall
mesh_terms: D000818:Animals; D006360:Heat-Shock Proteins / Q000145:classification* / Q000502:physiology*; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism
chemical_list: D006360:Heat-Shock Proteins; D018836:Inflammation Mediators