title: Iron chelation with deferasirox in two patients with HFE hemochromatosis and chronic anemia.
abstract: We present 2 patients with hyperferritinemia, increased liver iron and hemochromatosis-associated HFE genotypes. At diagnosis, both patients had chronic anemia that prevented initiation of phlebotomy. Iron chelation with deferasirox proved to be a safe and effective means of substantially lowering ferritin levels.
authors.affiliation: Division of Hematology and Central Hematology Laboratory, Luzerner Kantonsspital, Lucerne, Switzerland. michael.nagler@ksl.ch
authors.forename: Michael
authors.initials: M
authors.lastname: Nagler
authors.forename: M
authors.initials: M
authors.lastname: Gregor
authors.forename: W A
authors.initials: WA
authors.lastname: Wuillemin
mesh_terms: D000368:Aged; D001565:Benzoates / Q000627:therapeutic use*; D015913:Chelation Therapy; D000077588:Deferasirox; D005260:Female; D005838:Genotype; D006432:Hemochromatosis / Q000188:drug therapy*; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D001565:Benzoates; C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D007502:Iron Chelating Agents; D008565:Membrane Proteins; D014230:Triazoles; D000077588:Deferasirox