title: Effects of domperidone on gastric emptying: a crossover study using a continuous real-time 13C breath test (BreathID system).
abstract: OBJECTIVE
  To determine the correlation between domperidone and gastric emptying using the continuous real time 13C breath-test (BreathID system), a novel non-invasive technique for measuring gastric emptying.
  
  
  METHODS
  Six healthy male volunteers participated in this randomized, two-way crossover study. Subjects fasted overnight and were randomly assigned to receive a test meal (400kcal per 400mL) 30 minutes after intake of domperidone (10mg) with 50 mL of water or intake of 50 mL of water alone. Gastric emptying was monitored for 4h after administration of the test meal by 13C-acetic acid breath test continually performed using the BreathID system. The time taken for emptying of 50% of the labeled meals (T1/2), the analog to the scintigraphy lag time for 10% emptying of the labeled meal (T lag), the gastric emptying coefficient (GEC), and the regression-estimated constants (beta and kappa) were calculated. Differences in the parameters measured at two time-points were analyzed using the Wilcoxon's signed-rank test.
  
  
  RESULTS
  No significant differences in calculated parameters (T lag, T1/2, GEC, beta or kappa) were observed between the treated and non-treated groups.
  
  
  CONCLUSIONS
  This study showed that domperidone had no effect on gastric emptying. The drug ameliorates nausea and vomiting via its antagonic activity against dopamine receptor. Therefore, domperidone probably ameliorates nausea through other mechanisms.
authors.affiliation: Gastroenterology Division, Yokohama City University School of Medicine, Kanazawaku, Yokohama, Japan.
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Shingo
authors.initials: S
authors.lastname: Kato
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sekino
authors.forename: Eiji
authors.initials: E
authors.lastname: Sakai
authors.forename: Takashi
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iida
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Hosono
authors.forename: Hiroki
authors.initials: H
authors.lastname: Endo
authors.forename: Koji
authors.initials: K
authors.lastname: Fujita
authors.forename: Tomoko
authors.initials: T
authors.lastname: Koide
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Masato
authors.initials: M
authors.lastname: Yoneda
authors.forename: Chikako
authors.initials: C
authors.lastname: Tokoro
authors.forename: Ayumu
authors.initials: A
authors.lastname: Goto
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Abe
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kubota
authors.forename: Shin
authors.initials: S
authors.lastname: Maeda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inamori
mesh_terms: D000328:Adult; D001944:Breath Tests; D002247:Carbon Isotopes; D018592:Cross-Over Studies; D004294:Domperidone / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male
chemical_list: D002247:Carbon Isotopes; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D004294:Domperidone