title: Glycated albumin may be a possible alternative to hemoglobin A1c in diabetic patients with anemia.
abstract: BACKGROUND
  We assessed whether glycated albumin (GA) is a useful glycemic indicator in diabetic patients with anemia who did not undergo dialysis.
  
  
  METHODS
  Hemoglobin A(1c) (HbA(1c)) and GA were simultaneously measured in 370 diabetic subjects who had not undergone dialysis. The relationship between GA and HbA(1c) was evaluated in patients with and without anemia.
  
  
  RESULTS
  GA-to-HbA(1c) ratio was significantly higher (3.3±0.7 vs. 2.8±0.5, p<0.001) and the regression slope between GA and HbA(1c) was steeper in diabetic patients with than in those without anemia (6.2 vs. 4.2, p<0.001).
  
  
  CONCLUSIONS
  HbA(1c) was underestimated in diabetic patients with anemia than in those without anemia, with the degree of underestimation increasing as glycemic control became poorer. GA may more accurately assess glycemic control in diabetic patients with anemia than HbA(1c).
authors.affiliation: Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
authors.forename: Sollip
authors.initials: S
authors.lastname: Kim
authors.forename: Won-Ki
authors.initials: WK
authors.lastname: Min
authors.forename: Sail
authors.initials: S
authors.lastname: Chun
authors.forename: Woochang
authors.initials: W
authors.lastname: Lee
authors.forename: Hae-Il
authors.initials: HI
authors.lastname: Park
mesh_terms: D000740:Anemia / Q000097:blood* / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D006442:Glycated Hemoglobin / Q000032:analysis*; D017127:Glycation End Products, Advanced; D006801:Humans; D008297:Male; D012044:Regression Analysis; D012709:Serum Albumin / Q000032:analysis*; D000093423:Glycated Serum Albumin
chemical_list: D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin