title: Maladaptive hypertrophy after acute myocardial infarction positive effect of bone marrow-derived stem cell therapy on regional remodeling measured by cardiac MRI.
abstract: OBJECTIVE
  In the aftermath of myocardial infarction, increased loading conditions will trigger hypertrophy of viable myocardium. This in turn causes deterioration of regional contractility. Cardiac magnetic resonance imaging (cMRI) allows the exact differentiation of viable and infarcted myocardium and therefore the measurement of regional wall thickness and function. Bone marrow-derived stem cell (BMC) transfer has been shown to improve global function and remodeling. The present study examines the effect of BMC transfer on regional remodeling and function after myocardial infarction by cMRI.
  
  
  METHODS
  Fifty-four patients of the MR substudy of the REPAIR-AMI trial have been studied at baseline and 12-month follow-up. Enddiastolic wall thickness (EDWT) and wall thickening (WT%) have been measured on SSFP cine sequences.
  
  
  RESULTS
  Enddiastolic wall thickness decreased in both placebo and BMC groups in viable as well as infarcted segments. The effect was largest in the pre-specified subgroup of patients below the median EF of 48.9% (infarcted segments -1.14 mm Placebo vs. -1.91 mm BMC, p for interaction 0.01, remote segments -0.19 mm Placebo vs. -0.94 mm BMC, p for interaction 0.00001). Corrected for baseline values BMC therapy yielded smaller EDWT at 12 months in infarcted and remote segments (infarcted 7.58 mm Placebo vs. 6.13 mm BMC p = 0.0001, remote 8.76 mm Placebo vs. 7.32 mm BMC, p = 0.0001). This was associated with better contractility within the infarcted segments among BMC patients (WT% 24.17% Placebo vs. 49.31% BMC, p = 0.0001). The WT% was inversely correlated with EDWT (r = -0.37, p = 0.0001).
  
  
  CONCLUSIONS
  Bone marrow-derived stem cell therapy yields smaller EDWT when compared with placebo patients suggesting a positive effect on maladaptive hypertrophy of viable myocardium. This notion is supported by the enhanced regional contractility within the BMC group which is inversely correlated with EDWT.
authors.affiliation: Department of Cardiology, Kerckhoff-Heart Center, Bad Nauheim, Germany. a.rolf@me.com
authors.forename: Andreas
authors.initials: A
authors.lastname: Rolf
authors.forename: Birgit
authors.initials: B
authors.lastname: Assmus
authors.forename: Volker
authors.initials: V
authors.lastname: Schächinger
authors.forename: Johannes
authors.initials: J
authors.lastname: Rixe
authors.forename: Susanne
authors.initials: S
authors.lastname: Möllmann
authors.forename: Helge
authors.initials: H
authors.lastname: Möllmann
authors.forename: Stefanie
authors.initials: S
authors.lastname: Dimmeler
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Zeiher
authors.forename: Christian W
authors.initials: CW
authors.lastname: Hamm
authors.forename: Thorsten
authors.initials: T
authors.lastname: Dill
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016026:Bone Marrow Transplantation; D005260:Female; D005858:Germany; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D016018:Least-Squares Analysis; D016014:Linear Models; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D020127:Recovery of Function; D033581:Stem Cell Transplantation; D013997:Time Factors; D014022:Tissue Survival; D016896:Treatment Outcome; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling