title: Renal giant cytoplasmic inclusions in Chédiak-Higashi syndrome: first ultrastructural demonstration in a human biopsy.
abstract: This report ultrastructurally illustrates the giant lysosome-related organelles in the various cellular components of a renal biopsy from a 10 year-old female affected by the Chédiak-Higashi syndrome. Albeit similar observations have been made and reported in animal models of the syndrome, to the author's knowledge, this is the first illustration of the changes as demonstrated in a human renal biopsy.
authors.affiliation: Department of Pathology and Laboratory Medicine, Drexel University College of Medicine and St. Christopher's Hospital for Children, Philadelphia, Pennsylvania, USA. J.deChadarevian@DrexelMed.edu
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: de Chadarévian
mesh_terms: D002609:Chediak-Higashi Syndrome / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007668:Kidney / Q000648:ultrastructure*; D008247:Lysosomes / Q000648:ultrastructure*; D046529:Microscopy, Electron, Transmission