title: Prophylactic antibiotics do not decrease the incidence of wound infections after laparoscopic pyloromyotomy.
abstract: OBJECTIVE
  Although laparoscopic pyloromyotomy is considered to be a clean case, many surgeons administer prophylactic preoperative antibiotics. The aim of this study was to evaluate the impact of prophylactic antibiotics on the wound infection rate after laparoscopic pyloromyotomy.
  
  
  METHODS
  We conducted a retrospective review of all patients who underwent laparoscopic pyloromyotomy at our institution between August 2002 and December 2009. Data included patient age, sex, weight, serum HCO(3) at admission and at operation, and if the patient received prophylactic antibiotics. The rate of wound infection or other wound complications, including suture granuloma, umbilical granuloma, umbilical hernia, skin dehiscence, and omental evisceration, was determined.
  
  
  RESULTS
  Two hundred ninety-nine patients underwent 301 consecutive laparoscopic pyloromyotomies. Sixty-four percent (n = 194) of patients returned for follow-up and were included in the study. Fifty-seven percent (group A, n = 111) received antibiotics, and 43% (group B, n = 84) did not. There were 3 wound infections in each of the equally matched groups (group A, 2.7%; group B, 3.5%; P = .73). Other wound complications occurred in 4.5% of patients (n = 5) in group A and 8.3% of patients (n = 7) in group B (P = .27).
  
  
  CONCLUSIONS
  The use of prophylactic antibiotics does not significantly decrease the rate of wound infection or other wound complications after laparoscopic pyloromyotomy.
authors.affiliation: Department of Pediatric Surgery, St. Christopher's Hospital for Children, Philadelphia, PA 19134, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Katz
authors.forename: Marshall Z
authors.initials: MZ
authors.lastname: Schwartz
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Moront
authors.forename: L Grier
authors.initials: LG
authors.lastname: Arthur
authors.forename: Shaheen J
authors.initials: SJ
authors.lastname: Timmapuri
authors.forename: Rajeev
authors.initials: R
authors.lastname: Prasad
mesh_terms: D019072:Antibiotic Prophylaxis; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods; D008297:Male; D011300:Preoperative Care / Q000379:methods; D011707:Pyloric Stenosis / Q000175:diagnosis / Q000601:surgery*; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000517:prevention & control; D016896:Treatment Outcome