title: [Interest of blood markers in predicting radiation-induced toxicity].
abstract: The oncologic outcome and the total dose are highly correlated with the treatment by ionizing radiation. The dose increase (total or per fraction) may provoke late-side effects that are potentially irreversible. The radiation-induced CD8 lymphocyte apoptotic value and the molecular modifications within the lymphocyte are capable of predicting the level of risk of developing late-side effects after curative intent radiotherapy. In this review, we present the different blood assays in this setting and discuss the current possibilities of researches, namely those involving the proteomic process.
authors.affiliation: Département de cancérologie radiothérapie, CRLC Val-d'Aurelle-Paul-Lamarque, rue Croix-Verte, Montpellier cedex 5, France.
authors.forename: J
authors.initials: J
authors.lastname: Lacombe
authors.forename: J
authors.initials: J
authors.lastname: Solassol
authors.forename: M
authors.initials: M
authors.lastname: Coelho
authors.forename: M
authors.initials: M
authors.lastname: Ozsahin
authors.forename: D
authors.initials: D
authors.lastname: Azria
mesh_terms: D017209:Apoptosis / Q000528:radiation effects; D015415:Biomarkers / Q000097:blood*; D018414:CD8-Positive T-Lymphocytes / Q000528:radiation effects; D002478:Cells, Cultured / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D016208:Databases, Factual; D005347:Fibroblasts / Q000528:radiation effects; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects; D006801:Humans; D018655:Lymphocyte Count; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D058958:Organs at Risk; D011446:Prospective Studies; D040901:Proteomics / Q000379:methods*; D011832:Radiation Injuries / Q000517:prevention & control*; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage
chemical_list: D015415:Biomarkers; D009363:Neoplasm Proteins