title: Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease.
abstract: Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2μg/μl saline; 5μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS+6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS+6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.
authors.affiliation: Department of Biology, Alexandru Ioan Cuza University, B-dul Carol I, No. 11, 700506 Iasi, Romania. hritcu@uaic.ro
authors.forename: Lucian
authors.initials: L
authors.lastname: Hritcu
authors.forename: Alin
authors.initials: A
authors.lastname: Ciobica
authors.forename: Marius
authors.initials: M
authors.lastname: Stefan
authors.forename: Marius
authors.initials: M
authors.lastname: Mihasan
authors.forename: Lavinia
authors.initials: L
authors.lastname: Palamiuc
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nabeshima
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D009498:Neurotoxins / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D016627:Oxidopamine / Q000633:toxicity; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008070:Lipopolysaccharides; D009498:Neurotoxins; D016627:Oxidopamine