title: Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia.
abstract: OBJECTIVE
  To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin (6-OHMS), in functional dyspepsia (FD).
  
  
  METHODS
  Ninety individuals were enrolled in the study: 30 in each study group: patients with postprandial distress syndrome (PDS), epigastric pain syndrome (EPS), and controls. Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed. Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum melatonin concentration at night and in the morning was significantly (P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL, quartile range (QR): 79.8-116.2; at 09.00 h-14.3 pg/mL, QR: 7.06-19.0] than in EPS (57.2 pg/mL, QR: 42.6-73.1; 8.1 pg/mL, QR: 4.1-9.3) and control patients (57.7 pg/mL, QR: 51.2-62.5; 8.1 pg/mL, QR: 5.4-10.3). A similar relationship was observed for urinary 6-OHMS excretion. Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes, whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms.
  
  
  CONCLUSIONS
  Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD.
authors.affiliation: Department of Gastroenterology, Medical University of Lodz, 90-647 Lodz, Poland. gastrologia@umed.lodz.pl
authors.forename: Cezary
authors.initials: C
authors.lastname: Chojnacki
authors.forename: Tomasz
authors.initials: T
authors.lastname: Poplawski
authors.forename: Grażyna
authors.initials: G
authors.lastname: Klupinska
authors.forename: Janusz
authors.initials: J
authors.lastname: Blasiak
authors.forename: Jan
authors.initials: J
authors.lastname: Chojnacki
authors.forename: Russel J
authors.initials: RJ
authors.lastname: Reiter
mesh_terms: D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology; D003937:Diagnosis, Differential; D004415:Dyspepsia / Q000097:blood* / Q000503:physiopathology / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000097:blood* / Q000652:urine; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology; D055815:Young Adult
chemical_list: C054513:6-sulfatoxymelatonin; D008550:Melatonin