title: Oxyfold: a simple and efficient solid-supported reagent for disulfide bond formation.
abstract: The synthesis and use of novel polymer-supported reagents for disulfide bond formation is described. This family of supported reagents consists of a series of oxidized methionines grafted onto a solid support. Their cost and the simplicity of their preparation through N-carboxyanhydride polymerization on beads make them reactants of choice for the formation of disulfide bridges in peptides.
authors.affiliation: Institut des Biomolécules Max Mousseron IBMM, UMR CNRS 5247, 15 avenue Charles Flahault, 34000 Montpellier, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Verdié
authors.forename: Luisa
authors.initials: L
authors.lastname: Ronga
authors.forename: Michèle
authors.initials: M
authors.lastname: Cristau
authors.forename: Muriel
authors.initials: M
authors.lastname: Amblard
authors.forename: Sonia
authors.initials: S
authors.lastname: Cantel
authors.forename: Christine
authors.initials: C
authors.lastname: Enjalbal
authors.forename: Karine
authors.initials: K
authors.lastname: Puget
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Gilles
authors.initials: G
authors.lastname: Subra
mesh_terms: D000595:Amino Acid Sequence; D004220:Disulfides / Q000737:chemistry; D008715:Methionine / Q000737:chemistry; D010084:Oxidation-Reduction; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D004220:Disulfides; D010455:Peptides; D011108:Polymers; D008715:Methionine