title: A study of metachronous cancer after endoscopic resection of early gastric cancer.
abstract: OBJECTIVE
  Endoscopic resection is commonly used for early gastric cancer (EGC) in Korea and Japan. There are only a few reports of metachronous cancer after endoscopic resection. The aim of this study was to identify clinical factors associated with metachronous gastric cancer after endoscopic resection.
  
  
  METHODS
  A total of 176 patients with EGC who had underwent endoscopic submucosal dissection (ESD) were periodically followed-up with endoscopic examinations from January 2004 to December 2007. The incidence and variable factors of metachronous gastric cancer were investigated in a retrospective study.
  
  
  RESULTS
  The median interval between the diagnosis of primary cancer and the diagnosis of the first metachronous cancer was 30 months (range 18-42 months). Metachronous gastric cancer had developed in nine patients (5.1%) during follow-up period and seven patients (4.0%) had synchronous gastric cancer lesions within 1 year of the initial endoscopic treatment. Annual incidence rate of metachronous cancer was approximately 3.3%. Antrum atrophy and old age were significantly associated with the incidence of metachronous cancer. The status of Helicobacter pylori, size, location and gross finding of lesion had no significant relationship with metachronous occurrence.
  
  
  CONCLUSIONS
  We should examine more carefully older patients who have atrophic gastritis because secondary cancer including metachronous cancer might occur in remnant stomach after initial successful endoscopic resection. And prospective study will be needed for the optimal endoscopic surveillance interval.
authors.affiliation: Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Ji Sun
authors.initials: JS
authors.lastname: Han
authors.forename: Jin Seok
authors.initials: JS
authors.lastname: Jang
authors.forename: Seok Reyol
authors.initials: SR
authors.lastname: Choi
authors.forename: Hyuk Chan
authors.initials: HC
authors.lastname: Kwon
authors.forename: Min Chan
authors.initials: MC
authors.lastname: Kim
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Jeong
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: You Jung
authors.initials: YJ
authors.lastname: Sohn
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000236:Adenoma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology* / Q000601:surgery; D005773:Gastroscopy; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology*; D011706:Pyloric Antrum / Q000473:pathology; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D013997:Time Factors