title: [The influence of ZnCl2 injected into the neostriatum on locomotor behavior of rats].
abstract: The influence of two-week daily microinjections of ZnCl2 into the rostral region of neostriatum on the locomotor behavior of Wistar rats in chronic experiments was studied. The 1-mcg dose of ZnCl2 decreased spontaneous locomotor activity in the "open field" and, beginning with the 5th day of microinjections, inhibited a shuttle-box conditioned avoidance reflex. The reflex recovered only in the first week after the injection withdrawal. The 0.1-mcg dose of ZnCl2 to a lesser extent affected the parameters of conditioned avoidance, whereas the level of spontaneous locomotor activity in this group of animals increased. The observed changes in rat behavior may be associated with the concentration-dependent influence of zinc ions on the ion channels in the membranes of neostriatum neurons, including glutamate activated. The possibility to control the activity of ion channels in a chronic behavioral experiment by zinc ion concentration is discussed.
authors.forename: A F
authors.initials: AF
authors.lastname: Iakimovskiĭ
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002413:Cations, Divalent / Q000378:metabolism / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D007267:Injections; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008124:Locomotion / Q000187:drug effects / Q000502:physiology*; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014131:Trace Elements / Q000378:metabolism* / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology / Q000502:physiology*; D017967:Zinc Compounds / Q000494:pharmacology
chemical_list: D002413:Cations, Divalent; D002712:Chlorides; D007473:Ion Channels; D014131:Trace Elements; D017967:Zinc Compounds; C016837:zinc chloride; D015032:Zinc