title: Characterization of three novel HLA-DRB1 alleles, DRB1*03:55, *11:46:02 and *04:92, by exon 2, 3 and 4 sequencing-based typing.
abstract: Sequencing-based typing of HLA-DRB1 gene, allowed us to characterize three new alleles. DRB1*03:55 shows one nucleotide change regarding DRB1*03:01:01G, resulting in an amino acid replacement at position 80 R > I. DRB1*11:46:02 presents one synonymous nucleotide change at codon 34 (CAG > CAA) with regard to DRB1*11:46:01. Finally, DRB1*04:92 has one nucleotide change from DRB1*04:07:01 at codon 207 in exon 4, producing an amino acid replacement (V > M) in the transmembrane domain.
authors.affiliation: Histocompatibilidad, Centro de Transfusión de Comunidad de Madrid, Madrid, Spain. abalas.trans@salud.madrid.org
authors.forename: A
authors.initials: A
authors.lastname: Balas
authors.forename: F
authors.initials: F
authors.lastname: García-Sánchez
authors.forename: J L
authors.initials: JL
authors.lastname: Vicario
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution / Q000235:genetics*; D001483:Base Sequence; D005091:Exons; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D017422:Sequence Analysis, DNA
chemical_list: D059811:HLA-DRB1 Chains