title: [Side effects analyses in consideration of renal function for S-1-administered patients].
abstract: Although many analyses of S-1 side effects are reported, there are no reports where the analyses of side effects were performed in consideration of renal function, which is an important index of medication dose. Therefore, we investigated side effects in consideration of renal function. The subjects were 163 patients administered S-1 at the Department of Surgery of Ogaki Municipal Hospital, between October 2008 and December 2009. The frequency and severity of side effects were high and serious in the groupwhose creatinine clearance was low. A significant difference was observed among 3 groups with regard to thrombocytopenia and dehydration. In conclusion, we think that pharmacists must take renal function into consideration when administering medication, to keepclose medicinal guidance, and to actively observe progress.
authors.affiliation: Dept. of Pharmacy, Ogaki Municipal Hospital.
authors.forename: Mina
authors.initials: M
authors.lastname: Iwai
authors.forename: Michio
authors.initials: M
authors.lastname: Kimura
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yasuda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D003401:Creatine / Q000652:urine; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000503:physiopathology* / Q000652:urine; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D005641:Tegafur / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D003401:Creatine