title: Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.
abstract: Isomalyngamide A (1) and A-1 (2) were isolated from the Taiwanese Lyngbya majuscule and the latter structure was elucidated by a combination of NMR spectroscopic analysis and HRESIMS measurement. We report the isolation of isomalyngamide A (1), discovery of isomalyngamide A-1 (2) and their synthetic analogs (3-9), which are further demonstrated to have therapeutic potential against tumor cell migration at the level of nanomolar to micromolar ranges, perhaps, by inactivating the expression of p-FAK, FAK, p-Akt and Akt through β1 integrin-mediated antimetastatic pathway.
authors.affiliation: Institute of Chemistry, Academia Sinica, 128 Sec 2, Academia Road, Taipei 115, Taiwan.
authors.forename: Tzu Ting
authors.initials: TT
authors.lastname: Chang
authors.forename: Shivaji V
authors.initials: SV
authors.lastname: More
authors.forename: I-Hsuan
authors.initials: IH
authors.lastname: Lu
authors.forename: Jui-Ching
authors.initials: JC
authors.lastname: Hsu
authors.forename: Ting-Ju
authors.initials: TJ
authors.lastname: Chen
authors.forename: Ya Ching
authors.initials: YC
authors.lastname: Jen
authors.forename: Chung-Kuang
authors.initials: CK
authors.lastname: Lu
authors.forename: Wen-Shan
authors.initials: WS
authors.lastname: Li
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
chemical_list: D000577:Amides; D019012:Integrin beta1; D011758:Pyrroles; C421003:isomalyngamide A; D051416:Focal Adhesion Protein-Tyrosine Kinases; D051057:Proto-Oncogene Proteins c-akt