title: Enantioselective synthesis of tertiary alcohols through a zirconium-catalyzed Friedel-Crafts alkylation of pyrroles with α-ketoesters.
abstract: Chiral complexes of 1,1'-bi-2-naphthol-based ligands with zirconium tert-butoxide catalyze the Friedel-Crafts alkylation of pyrroles with α-ketoesters to afford tertiary alcohols in good yields and ee up to 98%. The reaction is also of application to 4,7-dihydroindole to give C2-alkylated indoles after oxidation with p-benzoquinone.
authors.affiliation: Departament de Química Orgànica, Facultat de Química, Universitat de València, C/Dr. Moliner 50, E-46100 Burjassot (València), Spain.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Blay
authors.forename: Isabel
authors.initials: I
authors.lastname: Fernández
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Muñoz
authors.forename: José R
authors.initials: JR
authors.lastname: Pedro
authors.forename: Alejandro
authors.initials: A
authors.lastname: Recuenco
authors.forename: Carlos
authors.initials: C
authors.lastname: Vila