title: Design and synthesis of novel functional lipid-based bioconjugates for drug delivery and other applications.
abstract: The modification of biologicals such as proteins/peptides, small molecules, and other polymers with lipids provides an efficient method for mediating their insertion into liposomes and lipid-core micellar nanocarriers. In this chapter, we describe several representative protocols developed in our laboratory for the bioconjugation of liposomes and lipid-core micelles for drug/gene delivery and diagnostic imaging applications.
authors.forename: Rupa R
authors.initials: RR
authors.lastname: Sawant
authors.forename: Vladimir P
authors.initials: VP
authors.lastname: Torchilin
mesh_terms: D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D015195:Drug Design; D004355:Drug Stability; D015696:Gene Products, tat / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D008823:Micelles; D057054:Molecular Imaging; D049329:Nanostructures / Q000737:chemistry; D004369:Pentetic Acid / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry
chemical_list: D000911:Antibodies, Monoclonal; D002614:Chelating Agents; D004337:Drug Carriers; D015696:Gene Products, tat; D008055:Lipids; D008081:Liposomes; D008823:Micelles; D010714:Phosphatidylethanolamines; C483858:phosphatidylethanolamine; D011092:Polyethylene Glycols; D004369:Pentetic Acid; D011094:Polyethyleneimine; D004247:DNA; D001205:Ascorbic Acid