title: Renal perfusion: noninvasive measurement with multidetector CT versus fluorescent microspheres in a pig model.
abstract: OBJECTIVE
  To validate the measurement of renal perfusion with multidetector computed tomography (CT) with a low-rate injection of contrast medium (ie, 3 mL/sec) through a catheter placed peripherally with gamma variate extended modeling in a pig model, compared with a reference method of fluorescent microspheres.
  
  
  METHODS
  This study was approved by the Institutional Animal Care and Use Committee. Renal perfusion was measured in 10 anesthetized pigs simultaneously with multidetector CT and with fluorescent microspheres, which are the reference standard for measuring regional renal perfusion. In each pig, measurements were obtained under three conditions. These were dopamine infusion, dopamine infusion with vascular expansion, and angiotensin II infusion. Aortic and cortical time-attenuation curves were modeled to measure renal perfusion with the gamma variate model. The renal perfusion measurements with the multidetector CT and that with microspheres were compared with least squares regression analysis and Bland-Altman plots.
  
  
  RESULTS
  Perfusion as measured with multidetector CT and that as measured with microspheres were strongly correlated (ρ = 0.93, P < .0001). Multidetector CT renal perfusion with dopamine infusion (3.13 mL/min/g ± 0.53) was not changed after volume expansion (3.37 mL/min/g ± 0.75, P = .35) but was significantly decreased after angiotensin II injection (2.01 mL/min/g ± 0.57, P = .0001).
  
  
  CONCLUSIONS
  Multidetector CT provides reliable measurements of single-kidney perfusion with peripheral low-rate contrast medium injection.
authors.affiliation: Department of Nephrology, Hôpital Edouard Herriot, Hospices Civils de Lyon, 5 place d'Arsonval, Pavillon P, 69437, Cedex 03, Lyon, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lemoine
authors.forename: Matthieu
authors.initials: M
authors.lastname: Papillard
authors.forename: Amélie
authors.initials: A
authors.lastname: Belloi
authors.forename: Nicolas
authors.initials: N
authors.lastname: Rognant
authors.forename: Denis
authors.initials: D
authors.lastname: Fouque
authors.forename: Maurice
authors.initials: M
authors.lastname: Laville
authors.forename: Olivier
authors.initials: O
authors.lastname: Rouvière
authors.forename: Laurent
authors.initials: L
authors.lastname: Juillard
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging*; D016018:Least-Squares Analysis; D008863:Microspheres; D023421:Models, Animal; D011857:Radiographic Image Interpretation, Computer-Assisted; D013552:Swine; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D000804:Angiotensin II; D004298:Dopamine