title: Angiogenesis in hand chondroma: an immunohistochemical study.
abstract: Hand chondroma is a particular cartilagineous tumour, being clinically benign, but morphologically malignant. This study investigates the expression of VEGF together with other growth factors and proliferation markers such as TGFβ2, Ki-67, TNF, FGF1, P53 in 8 cases of hand chondroma treated with courettage, in order to define the ethiopathogenesis of this tumour and the clinical significance of the resulting immunohistochemical profile, with particular respect to angiogenesis. VEGF was expressed in all cases; 5 cases were positive for TFGβ2 and 3 for PDGF. None of the other factors was expressed. On the basis of histologic results a specific model of tumour progression based on the indicators of angiogenesis could be related to hand tumours, in which VEGF expression should be the first stadium of the tumour aggressiveness, and the following PDGF, TGF 2 expression should be accompanied with a morphological outline worsening. Nevertheless the non constant expression of these indicators and the absent expression of proliferated indicators can explain the scant tendency to the relapse in presence of accurate curettage. It is important to remember that the cellular polymorphism typical of the cartilaginous tumours does not allow the application of an only oncogenesis model.
authors.affiliation: Department of Orthopedics, Catholic University of Rome, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Ricciardella
authors.forename: E D
authors.initials: ED
authors.lastname: Rossi
authors.forename: G
authors.initials: G
authors.lastname: Fadda
authors.forename: C
authors.initials: C
authors.lastname: Graci
authors.forename: M S
authors.initials: MS
authors.lastname: Spinelli
authors.forename: G
authors.initials: G
authors.lastname: Falcone
authors.forename: M A
authors.initials: MA
authors.lastname: Rosa
authors.forename: G
authors.initials: G
authors.lastname: Maccauro
mesh_terms: D000328:Adult; D002357:Cartilage Diseases / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D049109:Cell Proliferation; D002648:Child; D002812:Chondroma / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D005260:Female; D006225:Hand; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009369:Neoplasms / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis / Q000235:genetics
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A