title: Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy.
abstract: PROBLEM  The aim of this study was to investigate the phenotype and commitment of decidual haematopoietic progenitor cells (HPCs) in healthy pregnant women and in women with early miscarriage. METHOD OF STUDY  Peripheral blood and decidual tissue from healthy and pathological pregnant women were examined for HPCs and lymphoid progenitors using flow cytometric analysis. RESULTS  Compared with peripheral blood, we found a significant increase in decidual HPCs in both healthy pregnant women and women with spontaneous abortion. T/NK, natural killer (NK), gamma-delta and NKT cell progenitors were identified in all peripheral blood and decidual samples. In pathologic pregnant women, the ratios of decidual T/NK and NK cell progenitors were significantly increased compared with healthy pregnant controls. CONCLUSION  We demonstrated decidual cells with haematopoietic progenitor cell phenotype in human decidua. Increased levels of NK progenitors in the decidua of women with early spontaneous abortion suggest a dysregulation of this pathway that may contribute to pregnancy failure.
authors.affiliation: Department of Medical Microbiology and Immunology, University of Pecs, Medical School, Hungary. laszlo.szereday@aok.pte.hu
authors.forename: Laszlo
authors.initials: L
authors.lastname: Szereday
authors.forename: Eva
authors.initials: E
authors.lastname: Miko
authors.forename: Matyas
authors.initials: M
authors.lastname: Meggyes
authors.forename: Aliz
authors.initials: A
authors.lastname: Barakonyi
authors.forename: Balint
authors.initials: B
authors.lastname: Farkas
authors.forename: Akos
authors.initials: A
authors.lastname: Varnagy
authors.forename: Jozsef
authors.initials: J
authors.lastname: Bodis
authors.forename: Lydia
authors.initials: L
authors.lastname: Lynch
authors.forename: Cliona
authors.initials: C
authors.lastname: O'Farrelly
authors.forename: Julia
authors.initials: J
authors.lastname: Szekeres-Bartho
mesh_terms: D000022:Abortion, Spontaneous / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D019002:CD56 Antigen / Q000276:immunology / Q000378:metabolism; D003656:Decidua / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018655:Lymphocyte Count; D008875:Middle Aged; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
chemical_list: D019002:CD56 Antigen