title: Successful pulmonary artery embolectomy in a patient with a saddle Wilms tumor embolus.
abstract: Denys-Drash syndrome is a genetic disorder characterized by ambiguous genitalia, cryptorchidism, nephrotic syndrome, and a high predilection for Wilms tumor with intravascular invasion. We report a 5-year-old male with Denys-Drash syndrome who rapidly developed Wilms tumor with vascular invasion, subsequent saddle tumor embolus, and required emergent embolectomy. This case illustrates the rapid emergence of Wilms tumor in a patient with Denys-Drash syndrome and the importance of considering embolectomy over thrombolytic therapy for PE in this population, given a high likelihood of tumor embolus.
authors.affiliation: Section of Critical Care, The Children's Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado, USA. cooper.lindsey@tchden.org
authors.forename: Lindsey
authors.initials: L
authors.lastname: Cooper
authors.forename: Colin
authors.initials: C
authors.lastname: Moore
authors.forename: Brian
authors.initials: B
authors.lastname: Branchford
authors.forename: Brian
authors.initials: B
authors.lastname: Greffe
authors.forename: Kelley
authors.initials: K
authors.lastname: Capocelli
authors.forename: Austine
authors.initials: A
authors.lastname: Kuder
authors.forename: Inder
authors.initials: I
authors.lastname: Mehta
authors.forename: Peter M
authors.initials: PM
authors.lastname: Mourani
mesh_terms: D002675:Child, Preschool; D030321:Denys-Drash Syndrome / Q000150:complications*; D017128:Embolectomy; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications*; D008297:Male; D011651:Pulmonary Artery / Q000601:surgery*; D011655:Pulmonary Embolism / Q000601:surgery*; D009396:Wilms Tumor / Q000150:complications*