title: pH-controlled reversible drug binding and release using a cytosine-rich hairpin DNA.
abstract: Here we report that a cytosine-rich DNA carrier, that oscillates between a hairpin and an i-motif structure in its response to pH variation, can be used as a drug binding and release device.
authors.affiliation: Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun, Jilin 130022, China.
authors.forename: Can
authors.initials: C
authors.lastname: Xu
authors.forename: Chuanqi
authors.initials: C
authors.lastname: Zhao
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D020862:GC Rich Sequence; D006801:Humans; D006863:Hydrogen-Ion Concentration; D055029:Inverted Repeat Sequences; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011522:Protons; D016615:Telomere / Q000235:genetics
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011522:Protons; D004247:DNA