title: Agreement between spectral domain optical coherence tomography and retinal nerve fiber layer photography in chinese.
abstract: OBJECTIVE
  To compare spectral domain optical coherence tomography (OCT) and fundus photography to identify localized retinal nerve fiber layer defects (RNFLD) in Chinese patients with early-to-medium advanced glaucoma.
  
  
  METHODS
  Thirty-nine patients (48 eyes) with localized RNFLDs by fundus photography and 48 age-matched control individuals were included into the study. The individuals underwent spectral domain OCT of the retinal nerve layer. In OCT, a localized RNFLD was defined as a dipping of the retinal nerve fiber layer thickness curve into the red-colored band of the graph, measured at a peripapillary circle with a diameter of 3.46 mm.
  
  
  RESULTS
  In the 48 eyes of the study group, 63 localized RNFLDs were seen on the fundus photographs. On the OCTs, 58 of these 63 localized RNFLDs were detected, whereas 5 defects were not detected. Two localized RNFLDs seen on the OCTs were not found on the corresponding fundus photographs. The resulting sensitivity and specificity of OCT for detecting localized RNFLDs were 92% and 96%, respectively. The overall agreement rate between both methods was 94% (90/96), and the κ value was 0.90 (P<0.001). The results of both techniques correlated with each other for the determination of the location (Pearson correlation coefficient (r)=0.99; P<0.001) and the width of the localized RNFLDs (201 ± 123 degrees vs. 207 ± 115 degrees; r=0.93; P<0.001).
  
  
  CONCLUSIONS
  Spectral domain OCT as compared with examiner-performed assessment of conventional fundus photographs is capable of detecting and measuring localized retinal nerve fiber layer defects with a relatively high diagnostic precision.
authors.affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Xi-Shi
authors.initials: XS
authors.lastname: Wu
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.forename: Jost B
authors.initials: JB
authors.lastname: Jonas
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Chang-Xi
authors.initials: CX
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology; D002908:Chronic Disease; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000208:ethnology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000208:ethnology; D010781:Photography; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence; D055815:Young Adult