title: Balticolid: a new 12-membered macrolide with antiviral activity from an ascomycetous fungus of marine origin.
abstract: A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R,11R), (4E,8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC₅₀ value of 0.45 μM.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Garyounis University, P.O. Box 5341, Benghazi, Libya.
authors.forename: Muftah A M
authors.initials: MAM
authors.lastname: Shushni
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Garyounis University, P.O. Box 5341, Benghazi, Libya.
authors.forename: Rajinder
authors.initials: R
authors.lastname: Singh
authors.affiliation: Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Strasse 17, D-17487 Greifswald, Germany.
authors.forename: Renate
authors.initials: R
authors.lastname: Mentel
authors.affiliation: Friedrich-Loffler-Institute of Medical Microbiology, Ernst-Moritz-Arndt-University, Martin-Luther-Strasse 6, D-17487 Greifswald, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lindequist
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012623:Seawater / Q000382:microbiology*; D014871:Water Microbiology
chemical_list: C562182:3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione; D000998:Antiviral Agents; D018942:Macrolides