title: The Vaccine Formulation Laboratory: a platform for access to adjuvants.
abstract: Adjuvants are increasingly used by the vaccine research and development community, particularly for their ability to enhance immune responses and for their dose-sparing properties. However, they are not readily available to the majority of public sector vaccine research groups, and even those with access to suitable adjuvants may still fail in the development of their vaccines because of lack of knowledge on how to correctly formulate the adjuvants. This shortcoming led the World Health Organization to advocate for the establishment of the Vaccine Formulation Laboratory at the University of Lausanne, Switzerland. The primary mission of the laboratory is to transfer adjuvants and formulation technology free of intellectual property rights to academic institutions, small biotechnology companies and developing countries vaccine manufacturers. In this context, the transfer of an oil-in-water emulsion to Bio Farma, an Indonesian vaccine manufacturer, was initiated to increase domestic pandemic influenza vaccine production capacity as part of the national pandemic influenza preparedness plan.
authors.affiliation: Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland. nicolas.collin@unil.ch
authors.forename: Nicolas
authors.initials: N
authors.lastname: Collin
authors.forename: Patrice M
authors.initials: PM
authors.lastname: Dubois
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006801:Humans; D013557:Switzerland; D018581:Technology Transfer; D013678:Technology, Pharmaceutical / Q000191:economics / Q000331:legislation & jurisprudence / Q000379:methods; D014612:Vaccines / Q000737:chemistry* / Q000276:immunology*; D014944:World Health Organization
chemical_list: D000276:Adjuvants, Immunologic; D014612:Vaccines