title: Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects.
abstract: In recent years, oxidative stress has been postulated to be an important factor in the pathogenesis and development of lifestyle-related diseases. In this study, we investigated the association between the derivatives of reactive oxygen metabolites (d-ROMs), as an index of products of reactive oxygen species (ROS), and biological antioxidant potential (BAP), as an index of antioxidant potential. We also investigated the associations between d-ROMs or BAP and the risk factors for lifestyle-related diseases or metabolic syndrome-associated factors to evaluate their usefulness in preventive medicine. There were 442 subjects who underwent health checkup examination in our facilities. In addition to standard medical checkup items, we analyzed d-ROMs, BAP, brachial-ankle pulse wave velocity, high-sensitivity C-reactive protein level and visceral fat area (VFA) visualized on a computed tomography scan. The mean d-ROM value in females was significantly higher than that in males. There was a positive correlation between the d-ROM and VFA levels. On correlation analysis, there was a negative correlation between the d-ROM and creatinine levels. As factors that influence d-ROMs, the level of VFA was selected, suggesting the significance of oxidative stress measurement with d-ROMs. In addition, there was a positive correlation between d-ROMs and BAP values. Further research is required to resolve whether increased production of ROS or the antioxidant potential that can compensate for such an increase of ROS is more important in vivo.
authors.affiliation: Center for Preventive Medical Treatment, NTT West Takamatsu Hospital, Takamatsu, Japan. ftoshi@kagawa.west.ntt.co.jp
authors.forename: Toshiki
authors.initials: T
authors.lastname: Fukui
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Mie
authors.initials: M
authors.lastname: Maruyama
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yasuda
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kohno
authors.forename: Youichi
authors.initials: Y
authors.lastname: Abe
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism / Q000502:physiology*; D044466:Asian People; D001916:Brachial Artery / Q000503:physiopathology; D002097:C-Reactive Protein / Q000032:analysis / Q000502:physiology; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000502:physiology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D011673:Pulsatile Flow / Q000502:physiology; D011859:Radiography; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D002097:C-Reactive Protein; D003404:Creatinine