title: Investigation of the efficacy of micafungin in the treatment of histoplasmosis using two North American strains of Histoplasma capsulatum.
abstract: Micafungin alone and combined with liposomal amphotericin B was evaluated against two strains of Histoplasma capsulatum. Micafungin was active in vitro against the mold but not the yeast form but was ineffective in vivo. Micafungin appears to be ineffective in treatment of histoplasmosis.
authors.affiliation: Pulmonary-Critical Care and Infectious Diseases, Roudebush VA Medical Center and Indiana University, 1481 W. 10th St., 111P-IU, Indianapolis, IN 46202, USA. chage@iupui.edu
authors.forename: Chadi A
authors.initials: CA
authors.lastname: Hage
authors.forename: Patricia
authors.initials: P
authors.lastname: Connolly
authors.forename: Daniel
authors.initials: D
authors.lastname: Horan
authors.forename: Michelle
authors.initials: M
authors.lastname: Durkin
authors.forename: Melinda
authors.initials: M
authors.lastname: Smedema
authors.forename: Robert
authors.initials: R
authors.lastname: Zarnowski
authors.forename: Patricia
authors.initials: P
authors.lastname: Smith
authors.forename: L Joseph
authors.initials: LJ
authors.lastname: Wheat
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D054714:Echinocandins / Q000494:pharmacology* / Q000627:therapeutic use*; D006658:Histoplasma / Q000187:drug effects* / Q000472:pathogenicity; D006660:Histoplasmosis / Q000188:drug therapy*; D055666:Lipopeptides / Q000494:pharmacology* / Q000627:therapeutic use*; D000077551:Micafungin; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin