title: Rhino-cerebral zygomycosis after allogeneic transplant: case report and literature review.
abstract: The proportion of patients with hematological malignancies (HM) who develop rare invasive fungal infections (IFI) has increased worldwide over the past few decades. Zygomycosis is an opportunistic fungal infection, which begins in the nose and paranasal sinuses due to inhalation of fungal spores. Rhino-cerebral zygomycosis is the most common form of the disease, it typically develops in diabetic or immunocompromised patients and presents as an acute fulminate infection, which is often lethal. We report a case of rhino-cerebral zygomycosis in an allotransplanted patient to emphasize early diagnosis and treatment of this potentially fatal fungal infection. We discuss different risk factors, specific diagnosis procedures and review the current concepts in management of zygomycosis.
authors.affiliation: Bone Marrow Transplantation Unit, Fundeni Clinical Institute, Bucharest, Romania. alinadanielatanase@yahoo.com
authors.forename: Alina
authors.initials: A
authors.lastname: Tănase
authors.forename: Zsofia
authors.initials: Z
authors.lastname: Varady
authors.forename: D
authors.initials: D
authors.lastname: Coriu
authors.forename: Carmen
authors.initials: C
authors.lastname: Orban
authors.forename: Camellia
authors.initials: C
authors.lastname: Ghiţă
authors.forename: M
authors.initials: M
authors.lastname: Grasu
authors.forename: A
authors.initials: A
authors.lastname: Streinu Cercel
authors.forename: V
authors.initials: V
authors.lastname: Del Bono
mesh_terms: D000293:Adolescent; D001921:Brain / Q000382:microbiology* / Q000473:pathology*; D006801:Humans; D008297:Male; D009668:Nose Diseases / Q000150:complications* / Q000209:etiology / Q000382:microbiology*; D010256:Paranasal Sinuses / Q000382:microbiology / Q000473:pathology; D014184:Transplantation, Homologous / Q000009:adverse effects*; D020096:Zygomycosis / Q000150:complications* / Q000209:etiology*