title: Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid.
abstract: We examined the usefulness of brief neuropsychological tests and serum Aβ as a predictive test for detecting MCI/AD in older adults. Serum Aβ levels were measured from 208 subjects who were cognitively normal at enrollment and blood draw. Twenty-eight of the subjects subsequently developed MCI (n = 18) or AD (n = 10) over the follow-up period. Baseline measures of global cognition, memory, language fluency, and serum Aβ(1-42) and the ratio of serum Aβ(1-42)/Aβ(1-40) were significant predictors for future MCI/AD using Cox regression with demographic variables, APOE ε4, vascular risk factors, and specific medication as covariates. An optimal sensitivity of 85.2% and specificity of 86.5% for predicting MCI/AD was achieved using ROC analyses. Brief neuropsychological tests and measurements of Aβ(1-42) obtained via blood warrants further study as a practical and cost effective method for wide-scale screening for identifying older adults who may be at-risk for pathological cognitive decline.
authors.affiliation: Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA.
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Luis
authors.forename: Laila
authors.initials: L
authors.lastname: Abdullah
authors.forename: Ghania
authors.initials: G
authors.lastname: Ait-Ghezala
authors.forename: Benoit
authors.initials: B
authors.lastname: Mouzon
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Keegan
authors.forename: Fiona
authors.initials: F
authors.lastname: Crawford
authors.forename: Michael
authors.initials: M
authors.lastname: Mullan