title: Human papillomavirus infection in lung and esophageal cancers: analysis of 485 Asian cases.
abstract: The role of human papillomavirus (HPV) in the development of lung and esophageal cancer remains inconclusive, which is in contrast to the established role HPV plays in the development of uterine cervical cancer. One of the reasons for this is the difference among reported HPV infection rates in these cancers. An analysis of 485 lung and esophageal cancers (176 lung squamous cell carcinoma, 128 lung adenocarcinoma, 181 esophageal carcinoma) in eight institutions in Asia (Tokyo, Kochi, Kagoshima, and Okinawa, Japan; Seoul and Daegu, Korea; Changhua, Republic of China (Taiwan); Singapore, Singapore) was carried out in order to clarify infection rates with HPV. Samples were examined in one laboratory of the Department of Pathology, the University of Tokyo, Japan in order to avoid inter-laboratory variation using a combination of polymerase chain reaction and in situ hybridization (ISH). HPV was found in 6.3%, 7%, and 9.4% of patients with lung squamous cell carcinoma, lung adenocarcinoma, and esophageal cancer, respectively. Among the geographic areas surveyed, Kagoshima exhibited a significantly higher prevalence of HPV infection in cases of esophageal carcinoma (24.1%). There was no geographical difference in the infection rates of HPV in lung carcinomas. Subtype-specific ISH was also performed, which identified the high-risk HPV types 16/18 in the majority (75.7%) of the patients with lung and esophageal cancer positive for HPV.
authors.affiliation: Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Akiteru
authors.initials: A
authors.lastname: Goto
authors.forename: Chih-Ping
authors.initials: CP
authors.lastname: Li
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.forename: Toshiro
authors.initials: T
authors.lastname: Niki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ohtsuki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kitajima
authors.forename: Suguru
authors.initials: S
authors.lastname: Yonezawa
authors.forename: Chihaya
authors.initials: C
authors.lastname: Koriyama
authors.forename: Suminori
authors.initials: S
authors.lastname: Akiba
authors.forename: Hisataka
authors.initials: H
authors.lastname: Uchima
authors.forename: Yueh-Min
authors.initials: YM
authors.lastname: Lin
authors.forename: Kun-Tu
authors.initials: KT
authors.lastname: Yeh
authors.forename: Jae-Soo
authors.initials: JS
authors.lastname: Koh
authors.forename: Chul-Woo
authors.initials: CW
authors.lastname: Kim
authors.forename: Kun-Yong
authors.initials: KY
authors.lastname: Kwon
authors.forename: Min En
authors.initials: ME
authors.lastname: Nga
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukayama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001208:Asia / Q000453:epidemiology; D002277:Carcinoma / Q000821:virology*; D004938:Esophageal Neoplasms / Q000821:virology*; D005260:Female; D005838:Genotype; D006801:Humans; D017403:In Situ Hybridization; D008175:Lung Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence