title: Molecular epidemiology of measles in India, 2005-2010.
abstract: Measles is a childhood disease that causes great morbidity and mortality in India and worldwide. Because measles surveillance in India is in its infancy, there is a paucity of countrywide data on circulating Measles virus genotypes. This study was conducted in 21 of 28 States and 2 of 7 Union Territories of India by MeaslesNetIndia, a national network of 27 centers and sentinel practitioners. MeaslesNetIndia investigated 52 measles outbreaks in geographically representative areas from 2005 through June 2010. All outbreaks were serologically confirmed by detection of antimeasles virus immunoglobulin M (IgM) antibodies in serum or oral fluid samples. Molecular studies, using World Health Organization (WHO)-recommended protocols obtained 203 N-gene, 40 H-gene, and 4 M-gene sequences during this period. Measles genotypes D4, D7, and D8 were found to be circulating in various parts of India during the study period. Further phylogenetic analysis revealed 4 lineages of Indian D8 genotypes: D8a, D8b, D8c, and D8d. This study generated a large, countrywide sequence database that can form the baseline for future molecular studies on measles virus transmission pathways in India. This study has created support and capabilities for countrywide measles molecular surveillance that must be carried forward.
authors.affiliation: WHO Regional Measles Reference Laboratory, National Institute of Virology, Pune, India. niteenw@yahoo.com
authors.forename: Niteen
authors.initials: N
authors.lastname: Wairagkar
authors.forename: Deepika
authors.initials: D
authors.lastname: Chowdhury
authors.forename: Sunil
authors.initials: S
authors.lastname: Vaidya
authors.forename: Sarika
authors.initials: S
authors.lastname: Sikchi
authors.forename: Naseem
authors.initials: N
authors.lastname: Shaikh
authors.forename: Laxman
authors.initials: L
authors.lastname: Hungund
authors.forename: R S
authors.initials: RS
authors.lastname: Tomar
authors.forename: D
authors.initials: D
authors.lastname: Biswas
authors.forename: K
authors.initials: K
authors.lastname: Yadav
authors.forename: J
authors.initials: J
authors.lastname: Mahanta
authors.forename: V N R
authors.initials: VN
authors.lastname: Das
authors.forename: Prasanna
authors.initials: P
authors.lastname: Yergolkar
authors.forename: P
authors.initials: P
authors.lastname: Gunasekaran
authors.forename: D
authors.initials: D
authors.lastname: Raja
authors.forename: R
authors.initials: R
authors.lastname: Jadi
authors.forename: Nalini
authors.initials: N
authors.lastname: Ramamurty
authors.forename: A C
authors.initials: AC
authors.lastname: Mishra
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000706:statistics & numerical data; D005838:Genotype; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007194:India / Q000453:epidemiology; D007223:Infant; D008457:Measles / Q000453:epidemiology* / Q000821:virology*; D008459:Measles virus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D017720:Molecular Epidemiology; D010802:Phylogeny; D012698:Serologic Tests; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M