title: [A case of gastric cancer accompanied by disseminated carcinomatosis of bone marrow with DIC, and subdural hematoma successfully treated with sequential methotrexate and 5-fluorouracil therapy].
abstract: A 44-year-old man visited a nearby hospital because of severe headache. Brain MRI revealed a subdural hematoma, and he was transferred to the Department of Neurosurgery of our hospital. Burr hole surgery was performed on the second day of hospitalization because of an enlargement of the hematoma. Laboratory data on admission showed the presence of a disseminated intravascular coagulation(DIC). Bone marrow aspiration revealed metastases of signet ring cell carcinoma, and abdominalCT showed gastric cancer. He was diagnosed as having DIC with bone marrow metastases of advanced gastric cancer. Despite anti-DIC therapy and blood transfusion, his systemic bleeding tendency was not improved. The neurosurgeon therefore consulted with a palliative care team. Since the patient was still young, we considered that he should be treated with anti-cancer drugs. At first, his family did not accept chemotherapy because they were pessimistic about his prognosis. However, after he regained his consciousness, we were able to perform sequential MTX and 5-FU therapy with the consent of the patient and his family. The therapy was successful, and he recovered from DIC and was discharged on the 57th hospital day.
authors.affiliation: Dept. of Gastroenterology, Iwaki Kyoritsu General Hospital.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamagiwa
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Maejima
authors.forename: Norihiro
authors.initials: N
authors.lastname: Shimada
authors.forename: Naohiro
authors.initials: N
authors.lastname: Dairaku
authors.forename: Ayumi
authors.initials: A
authors.lastname: Narisawa
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Iwahashi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D019046:Bone Marrow Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000556:secondary; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006408:Hematoma, Subdural / Q000209:etiology*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
chemical_list: D005472:Fluorouracil; D008727:Methotrexate