title: No unexpected adverse events and biochemical side effects of olanzapine as adjunct treatment in adolescent girls with eating disorders.
abstract: OBJECTIVE
  Olanzapine has been recently tried to relieve anxiety and hyperactivity in adolescents with eating disorders (EDs). Presently, the side effects of the drug have been evaluated.
  
  
  METHODS
  Forty-seven adolescents with EDs were followed up by repeated blood sampling before, during, and at 3 months after medication with olanzapine.
  
  
  RESULTS
  Olanzapine medication was discontinued in three patients because of galactorrhea, seizures, and raised liver enzyme activities, respectively. There was a normalization of glucose, insulin, and lipid profiles during treatment, which was related to weight gain and resumption of menstruations but not to medication. Increases in thyroid-stimulating hormone and prolactin were related to olanzapine medication and comedication with selective serotonine reuptake inhibitors. Three months after discontinuing medication, there were no persisting biochemical effects.
  
  
  CONCLUSIONS
  The side effects observed were those previously described for olanzapine. Most biochemical changes were related to weight (change) and amenorrhea and not to medication. Placebo-controlled studies are needed to investigate the efficacy of olanzapine in adolescents with EDs.
authors.affiliation: Department of Women's and Children's Health, Uppsala University Children's Hospital, Uppsala, Sweden. ingemar.swenne@akademiska.se
authors.forename: Ingemar
authors.initials: I
authors.lastname: Swenne
authors.forename: Agneta
authors.initials: A
authors.lastname: Rosling
mesh_terms: D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D002648:Child; D001068:Feeding and Eating Disorders / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D000077152:Olanzapine
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine