title: A new neolignan and a new sesterterpenoid from the stems of Picrasma quassioides Bennet.
abstract: A new dihydrobenzofuran-type neolignan, picrasmalignan A (1), and a new sesterterpene lactone, 2'-isopicrasin A (4), were isolated from the stems of Picrasma quassioides Bennet, along with four known compounds, comprising two neolignans, 2 and 3, a sesterterpene lactone, 5, and a flavonol, 6. The structures of these compounds were determined by detailed analysis of NMR and MS data, and comparison with the literature data. Compounds 1-6 were tested for their anti-inflammatory activity, and 1-3 and 6 showed potent inhibitory activities on nitric oxide, tumor necrosis factor-α, and interleukin-6 production in mouse monocyte-macrophage RAW 264.7 stimulated by lipopolysaccharide (LPS).
authors.affiliation: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jiao
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Guang-Xiong
authors.initials: GX
authors.lastname: Zhou
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D015850:Interleukin-6 / Q000378:metabolism; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D032270:Picrasma / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D054830:Sesterterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C561750:2'-isopicrasin A; D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D015850:Interleukin-6; D007783:Lactones; D008070:Lipopolysaccharides; D054830:Sesterterpenes; D014409:Tumor Necrosis Factor-alpha; C561749:picrasmalignan A; D009569:Nitric Oxide