title: Resting-state functional connectivity indexes reading competence in children and adults.
abstract: Task-based neuroimaging studies face the challenge of developing tasks capable of equivalently probing reading networks across different age groups. Resting-state fMRI, which requires no specific task, circumvents these difficulties. Here, in 25 children (8-14 years) and 25 adults (21-46 years), we examined the extent to which individual differences in reading competence can be related to resting-state functional connectivity (RSFC) of regions implicated in reading. In both age groups, reading standard scores correlated positively with RSFC between the left precentral gyrus and other motor regions, and between Broca's and Wernicke's areas. This suggests that, regardless of age group, stronger coupling among motor regions, as well as between language/speech regions, subserves better reading, presumably reflecting automatized articulation. We also observed divergent RSFC-behavior relationships in children and adults, particularly those anchored in the left fusiform gyrus (FFG) (the visual word form area). In adults, but not children, better reading performance was associated with stronger positive correlations between FFG and phonology-related regions (Broca's area and the left inferior parietal lobule), and with stronger negative relationships between FFG and regions of the "task-negative" default network. These results suggest that both positive RSFC (functional coupling) between reading regions and negative RSFC (functional segregation) between a reading region and default network regions are important for automatized reading, characteristic of adult readers. Together, our task-independent RSFC findings highlight the importance of appreciating developmental changes in the neural correlates of reading competence, and suggest that RSFC may serve to facilitate the identification of reading disorders in different age groups.
authors.affiliation: Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience at New York University Child Study Center, New York, New York 10016, USA. makisophiakoyama@gmail.com
authors.forename: Maki S
authors.initials: MS
authors.lastname: Koyama
authors.forename: Adriana
authors.initials: A
authors.lastname: Di Martino
authors.forename: Xi-Nian
authors.initials: XN
authors.lastname: Zuo
authors.forename: Clare
authors.initials: C
authors.lastname: Kelly
authors.forename: Maarten
authors.initials: M
authors.lastname: Mennes
authors.forename: Devika R
authors.initials: DR
authors.lastname: Jutagir
authors.forename: F Xavier
authors.initials: FX
authors.lastname: Castellanos
authors.forename: Michael P
authors.initials: MP
authors.lastname: Milham
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D032882:Comprehension / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology*; D011932:Reading