title: Biocompatible micelles based on comb-like PEG derivates: formation, characterization, and photo-responsiveness.
abstract: A novel comb-like derivative CPEG-g-DNQ was prepared by incorporating light responsive 2-diazo-1,2-naphthoquinone (DNQ) groups into the structure of comb-like poly(ethylene glycol) (CPEG). DLS and TEM results showed that CPEG-g-DNQ self-assembled into spherical micelles with an average size of about 135 nm in water. Upon exposure to light, the micelles could be disrupted because of the conversion of hydrophobic DNQ to hydrophilic 3-indenecarboylic acid. Additionally, hydrophobic coumarin 102 was successfully loaded into the micelles and photo-induced ON-OFF release was demonstrated by fluorescence spectroscopy. MTT assay revealed that the micelles are biocompatible. These photo-responsive micelles might have great potential for controlled release of hydrophobic drugs.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Chao-Jian
authors.initials: CJ
authors.lastname: Chen
authors.forename: Gong-Yan
authors.initials: GY
authors.lastname: Liu
authors.forename: Ye-Ting
authors.initials: YT
authors.lastname: Shi
authors.forename: Cong-Shan
authors.initials: CS
authors.lastname: Zhu
authors.forename: Shao-Peng
authors.initials: SP
authors.lastname: Pang
authors.forename: Xiang-Sheng
authors.initials: XS
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation*; D056945:Hep G2 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D009285:Naphthoquinones / Q000737:chemistry; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D008823:Micelles; D009285:Naphthoquinones; D011108:Polymers; D011092:Polyethylene Glycols; C040756:1,2-naphthoquinone