title: [Correlation between blood T-cell receptor rearrangement excision circles levels and severe infection in children with acute lymphoblastic leukemia].
abstract: OBJECTIVE
  This study quantitatively examined signal joint T-cell receptor rearrangement excision circles (sjTRECs) levels in peripheral blood of children with acute lymphoblastic leukemia (ALL) at different stages in order to evaluate the role of sjTRECs in predicting severe infection postchemotherapy.
  
  
  METHODS
  sjTRECs levels in peripheral blood were measured by fluorescent quantitation-polymerase chain reaction in 30 children with newly diagnosed ALL, 36 children with ALL who accepted chemotherapy but were not infected, 30 children with ALL who had severe infection after chemotherapy, and 50 normal children.
  
  
  RESULTS
  Blood sjTRECs levels in the normal group (394 ± 270 copies/103 MNC) were significantly higher than those in the other three groups (P<0.05). Blood sjTRECs levels in the chemotherapy group without infection (96 ± 78 copies/103 MNC) were significantly lower than those in the newly diagnosed ALL group (210 ± 219 copies/103 MNC) (P<0.05). The chemotherapy group with severe infection showed the lowest blood sjTRECs levels (48 ± 40 copies/103 MNC) in the four groups.
  
  
  CONCLUSIONS
  The measurement of blood sjTRECs levels might be helpful for predicting the occurrence of severe infection postchemotherapy in children with ALL.
authors.affiliation: Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
authors.forename: Cheng-Juan
authors.initials: CJ
authors.lastname: Luo
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Jia-Le
authors.initials: JL
authors.lastname: Dai
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Shen
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Xue
authors.forename: Jing-Yan
authors.initials: JY
authors.lastname: Tang
authors.forename: Chang-Ying
authors.initials: CY
authors.lastname: Luo
authors.forename: Ci
authors.initials: C
authors.lastname: Pan
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Shen
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Long-Jun
authors.initials: LJ
authors.lastname: Gu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004270:DNA, Circular / Q000097:blood*; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology
chemical_list: D004270:DNA, Circular