title: Protein interactions with surfaces: Computational approaches and repellency.
abstract: Study of protein adsorption to solid surfaces continues to be substantial because of its role in cellular responses to biomaterials, interest in molecular aspects such as conformation and orientation, new methods for making protein repellent surfaces, and new application areas such as nanoparticles and microfluidics. This brief review is based only on very recent articles of particular interest to the authors, who each have worked in this area for some time. Simulations of protein interactions with surfaces and protein repellent surfaces are the only subtopics reviewed here.
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA 98195-5061, USA.
authors.forename: Luisa Mayorga
authors.initials: LM
authors.lastname: Szott
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Horbett
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D056004:Molecular Dynamics Simulation; D009010:Monte Carlo Method; D036103:Nanotechnology / Q000379:methods*; D011092:Polyethylene Glycols / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D011506:Proteins / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D013499:Surface Properties; D013816:Thermodynamics
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; D011506:Proteins; C524499:polyethylene glycol methacrylate; D011092:Polyethylene Glycols