title: Nanoparticles and inflammation.
abstract: The development of nanoscale molecular probes capable of diagnosis, characterization, and clinical treatment of disease is leading to a new generation of imaging technologies. Such probes are particularly relevant to inflammation, where the detection of subclinical, early disease states could facilitate speedier detection that could yield enhanced, tailored therapies. Nanoparticles offer robust platforms capable of sensitive detection, and early research has indicated their suitability for the detection of vascular activation and cellular recruitment at subclinical levels. This suggests that nanoparticle techniques may provide excellent biomarkers for the diagnosis and progression of inflammatory diseases with magnetic resonance imaging (MRI), fluorescent quantum dots (QDs), and surface enhanced Raman scattering (SERS) probes being just some of the new methodologies employed. Development of these techniques could lead to a range of sensitive probes capable of ultrasensitive, localized detection of inflammation. This article will discuss the merits of each approach, with a general overview to their applicability in inflammatory diseases.
authors.affiliation: Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Glasgow, U.K. ross.stevenson@strath.ac.uk
authors.forename: Ross
authors.initials: R
authors.lastname: Stevenson
authors.forename: Axel J
authors.initials: AJ
authors.lastname: Hueber
authors.forename: Alan
authors.initials: A
authors.lastname: Hutton
authors.forename: Iain B
authors.initials: IB
authors.lastname: McInnes
authors.forename: Duncan
authors.initials: D
authors.lastname: Graham
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods; D007249:Inflammation / Q000175:diagnosis*; D008280:Magnetics; D008856:Microscopy, Fluorescence / Q000379:methods; D015336:Molecular Probe Techniques; D053758:Nanoparticles / Q000032:analysis* / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods