title: KAPs off for HIV-1 integration.
abstract: Integration of reverse transcribed HIV-1 DNA into the host genome, catalyzed by HIV-1 integrase, represents an obligate step in establishing productive viral infection. Allouch et al. (2011) identify KAP1 (TRIM28) as an interaction partner of acetylated integrase. KAP1, in complex with HDAC1, represses HIV-1 integration through specific deacetylation of HIV-1 integrase.
authors.affiliation: Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Figueiredo
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hope
mesh_terms: D000107:Acetylation; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D019427:HIV Integrase / Q000235:genetics / Q000378:metabolism; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics / Q000502:physiology*; D006801:Humans; D011485:Protein Binding; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D000076183:Tripartite Motif-Containing Protein 28; D016662:Virus Integration
chemical_list: D012097:Repressor Proteins; C101116:TRIM28 protein, human; D000076183:Tripartite Motif-Containing Protein 28; D019427:HIV Integrase