title: Alterations in cyclic GMP levels in preeclampsia may reflect increased B-type natriuretic peptide levels and not impaired nitric oxide activity.
abstract: OBJECTIVE
  We compared nitrite, B-type natriuretic peptide (BNP), and cGMP levels in preeclamptic with those found in healthy pregnant.
  
  
  METHODS
  We studied 21 healthy pregnant and 27 preeclamptic. Plasma cGMP and BNP levels were determined by ELISA. Nitrite levels were determined by chemiluminescence.
  
  
  RESULTS
  Higher cGMP and BNP, and lower nitrite levels were found in preeclamptic versus healthy pregnant.
  
  
  CONCLUSIONS
  Altered cGMP levels reflect increased BNP levels and not impaired nitric oxide activity in preeclampsia.
authors.affiliation: Núcleo de Pós-Graduação e Pesquisa, Santa Casa de Belo Horizonte, Av. Francisco Sales 1111, Belo Horizonte, MG, Brazil.
authors.forename: Valeria C
authors.initials: VC
authors.lastname: Sandrim
authors.forename: Ana C T
authors.initials: AC
authors.lastname: Palei
authors.forename: Jonas T
authors.initials: JT
authors.lastname: Sertório
authors.forename: Lorena M
authors.initials: LM
authors.lastname: Amaral
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Cavalli
authors.forename: Jose E
authors.initials: JE
authors.lastname: Tanus-Santos
mesh_terms: D000328:Adult; D001794:Blood Pressure; D016022:Case-Control Studies; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012016:Reference Values; D055815:Young Adult
chemical_list: D009573:Nitrites; D020097:Natriuretic Peptide, Brain; D009569:Nitric Oxide; D006152:Cyclic GMP