title: Cholesteryl ester transfer protein gene and effectiveness of lipid lowering of atorvastatin.
abstract: Cholesteryl ester transfer protein (CETP) plays a key role in lipid metabolism. Thus, variations in the CETP gene may be clinically relevant. Newly started atorvastatin users (n=212) were genotyped for CETP genetic variants (TaqIB and I405V). Homozygotes for B1 allele of TaqIB polymorphism had lower plasma high density lipoprotein cholesterol (HDL-C) compared with B1B2 or B2B2 genotypes (p=0.03, for each). Homozygotes for I allele of I405V polymorphism had lower plasma HDL-C compared with IV or VV genotypes (p=0.001, for each). In the whole population, the B1 carriers increased HDL-C levels by 4% after atorvastatin treatment, compared with B2 carriers, where a 4% decrease occurred (p=0.03). Also homozygotes for B1 allele decreased triglyceride levels to a lesser, though not significant, degree compared to B1B2 or B2B2 genotypes. CETP TaqIB or I405V polymorphisms seem to modify the lipid lowering response to atorvastatin treatment. This knowledge may help design more effective hypolipidaemic treatment.
authors.affiliation: 1 Cardiology Department, Onassis Cardiac Surgery Center Athens, Greece.
authors.forename: Genovefa
authors.initials: G
authors.lastname: Kolovou
authors.forename: Constantinos
authors.initials: C
authors.lastname: Mihas
authors.forename: Katherine
authors.initials: K
authors.lastname: Anagnostopoulou
authors.forename: Vana
authors.initials: V
authors.lastname: Kolovou
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Giannakopoulou
authors.forename: Peggy
authors.initials: P
authors.lastname: Kostakou
authors.forename: Marianna
authors.initials: M
authors.lastname: Stamatelatou
authors.forename: Sophie
authors.initials: S
authors.lastname: Mavrogeni
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Degiannis
authors.forename: Dimitri P
authors.initials: DP
authors.lastname: Mikhailidis