title: Genetic association studies in peripheral arterial disease.
abstract: Peripheral artery disease (PAD) is a major health problem worldwide, affecting millions of patients. Although cardiovascular risk factors such as diabetes mellitus, tobacco abuse, hypertension, and hypercholesterolemia have been associated with the development of PAD, the possible existence of an inherited genetic predisposition to PAD has been investigated in numerous familial aggregation studies. A link between genetics and PAD may open new avenues for prevention of this morbid and mortal disorder. This is an overview of the potential association of genetics and PAD.
authors.affiliation: UC Davis Vascular Center, Sacramento, California, USA.
authors.forename: Yung-Wei
authors.initials: YW
authors.lastname: Chi
authors.forename: Olusegun
authors.initials: O
authors.lastname: Osinbowale
authors.forename: Richard
authors.initials: R
authors.lastname: Milani
mesh_terms: D055109:Ankle Brachial Index; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D016491:Peripheral Vascular Diseases / Q000235:genetics*; D012307:Risk Factors
chemical_list: D005819:Genetic Markers