title: Differential expression of the ADAMs in developing chicken retina.
abstract: The expression patterns of the seven members of the ADAM (a disintegrin and metalloprotease) family, ADAM9, ADAM10, ADAM12, ADAM13, ADAM17, ADAM22, and ADAM23 were analyzed in the developing chicken retina by in situ hybridization and immunohistochemistry. Results show that each individual ADAM is expressed and regulated spatiotemporally in the developing retinal layers. ADAM9, ADAM10 and ADAM17 are widely expressed in the differential layers of the retina throughout the whole embryonic period, while ADAM12 and ADAM13 are mainly expressed in the ganglion cell layer at a later stage. ADAM22 and ADAM23 are restricted to the inner nuclear layer and the ganglion cell layer at a later stage. Furthermore, ADAM10 protein is co-expressed with the four members of the classic cadherins, N-cadherin, R-cadherin, cadherin-6B and cadherin-7 in distinct retinal layers. Therefore, the differential expression of the investigated ADAMs in the developing retina suggests the contribution of them to the retina development.
authors.affiliation: Albrecht-Kossel-Institute for Neuroregeneration, School of Medicine University of Rostock, D-18147 Rostock, Germany.
authors.forename: Xin
authors.initials: X
authors.lastname: Yan
authors.forename: Juntang
authors.initials: J
authors.lastname: Lin
authors.forename: Arndt
authors.initials: A
authors.lastname: Rolfs
authors.forename: Jiankai
authors.initials: J
authors.lastname: Luo
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism*; D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D002642:Chick Embryo; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D012160:Retina / Q000196:embryology* / Q000378:metabolism
chemical_list: D015820:Cadherins; D051722:ADAM Proteins