title: Invasive pneumococcal disease: association between serotype, clinical presentation and lethality.
abstract: To ascertain the factors linked to invasive pneumococcal disease (IPD) caused by the different serotypes in the period 2007-2009, following the conjugate vaccine's inclusion in the childhood vaccination schedule, a total of 2013 IPD cases were reviewed. The mean annual incidence in this period was 10.74 cases per 100,000 inhabitans and the lethality was 8.8%. Overall serotype distribution displayed certain peculiarities, such as the high frequency of serotype 5. Serotype 3, male gender, sepsis and presence of risk factors were significantly associated with lethality. Vaccinated children under 5 years of age had a higher risk of disease due to serotype 19A. Serotype 8 was associated with the presence of underlying risk factors.
authors.affiliation: Dirección General de Atención Primaria, Subdirección de Promoción de la Salud y Prevención, Consejería de Sanidad, Comunidad de Madrid, Spain. angeles.gutierrez@salud.madrid.org
authors.forename: M Angeles Gutiérrez
authors.initials: MA
authors.lastname: Rodríguez
authors.forename: Amai Varela
authors.initials: AV
authors.lastname: González
authors.forename: María Ascensión Ordobás
authors.initials: MA
authors.lastname: Gavín
authors.forename: Fernando Martín
authors.initials: FM
authors.lastname: Martínez
authors.forename: Natividad García
authors.initials: NG
authors.lastname: Marín
authors.forename: Belén Ramos
authors.initials: BR
authors.lastname: Blázquez
authors.forename: Juan Carlos Sanz
authors.initials: JC
authors.lastname: Moreno
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007114:Immunization; D007223:Infant; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000276:immunology / Q000401:mortality; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011159:Population Surveillance; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000276:immunology*
chemical_list: D022242:Pneumococcal Vaccines