title: Directed formation of DNA nanoarrays through orthogonal self-assembly.
abstract: We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.
authors.affiliation: School of Chemistry, University of Southampton, Highfield, Southampton SO171BJ, UK.
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Burns
authors.forename: Jurgita
authors.initials: J
authors.lastname: Zekonyte
authors.forename: Giuliano
authors.initials: G
authors.lastname: Siligardi
authors.forename: Rohanah
authors.initials: R
authors.lastname: Hussain
authors.forename: Eugen
authors.initials: E
authors.lastname: Stulz
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry* / Q000648:ultrastructure; D006860:Hydrogen Bonding; D046228:Microarray Analysis; D008969:Molecular Sequence Data
chemical_list: D004247:DNA