title: Oxidative stress and endothelin-1 in atherosclerotic renal artery stenosis and effects of renal angioplasty.
abstract: OBJECTIVE
  To examine biomarkers of oxidative stress (oxs), and endothelin (ET)-1, in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) and to evaluate the effect of percutaneous transluminal renal angioplasty (PTRA).
  
  
  METHODS
  Baseline measurements were made immediately before renal angiography in patients with suspected ARAS (significant ARAS, n = 83, and non-RAS, n = 59) and in 20 healthy, matched controls. In patients with ARAS, analyses were repeated 4 weeks after PTRA. All patients were treated with statins and acetylsalicylic acid throughout.
  
  
  RESULTS
  At baseline there were no significant differences between groups in biomarkers of oxs, whereas high-sensitivity C-reactive protein and blood leukocytes were significantly elevated in group ARAS versus both healthy controls and group non-RAS. Plasma levels of ET-1 and uric acid were significantly increased in group ARAS versus healthy controls prior to angiography and were significantly reduced compared to baseline 4 weeks after PTRA. PTRA had no significant effects on biomarkers of oxs, inflammation or serum creatinine concentrations.
  
  
  CONCLUSIONS
  ARAS patients on treatment with antihypertensive agents, acetylsalicylic acid and statins showed elevated inflammatory indices but no increase in oxs. PTRA had no significant effects on inflammatory indices 4 weeks after intervention but reduced plasma ET-1 and uric acid.
authors.affiliation: Department of Molecular and Clinical Medicine/Nephrology, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. aso.saeed@vgregion.se
authors.forename: A
authors.initials: A
authors.lastname: Saeed
authors.forename: H
authors.initials: H
authors.lastname: Herlitz
authors.forename: E
authors.initials: E
authors.lastname: Nowakowska-Fortuna
authors.forename: U
authors.initials: U
authors.lastname: Nilsson
authors.forename: A
authors.initials: A
authors.lastname: Alhadad
authors.forename: G
authors.initials: G
authors.lastname: Jensen
authors.forename: I
authors.initials: I
authors.lastname: Mattiasson
authors.forename: B
authors.initials: B
authors.lastname: Lindblad
authors.forename: A
authors.initials: A
authors.lastname: Gottsäter
authors.forename: G
authors.initials: G
authors.lastname: Guron
mesh_terms: D000368:Aged; D017130:Angioplasty / Q000379:methods; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D019332:Endothelin-1 / Q000037:antagonists & inhibitors / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012078:Renal Artery Obstruction / Q000097:blood* / Q000473:pathology / Q000628:therapy; D014527:Uric Acid / Q000037:antagonists & inhibitors / Q000097:blood
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D014527:Uric Acid