title: Abnormal gamma and beta MEG activity during finger movements in early-onset psychosis.
abstract: Patients with psychosis often exhibit abnormalities in basic motor control, but little is known about the neural basis of these deficits. This study examines the neuro-dynamics of movement using magnetoencephalography (MEG) in adolescents with early-onset psychosis and typically developing controls. MEG data were imaged using beamforming then evaluated for task and group effects before, during, and after movement onsets. Primary findings included weaker activation in patients during movement execution in cerebellar cortices. Such aberrations likely contribute to the decreased motor control exhibited by patients with psychosis, and may reflect GABAergic-based inhibitory deficits comparable to those seen in cellular and system-level studies.
authors.affiliation: Department of Pharmacology & Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198-8422, USA. tony.w.wilson@gmail.com
authors.forename: Tony W
authors.initials: TW
authors.lastname: Wilson
authors.forename: Erin
authors.initials: E
authors.lastname: Slason
authors.forename: Ryan
authors.initials: R
authors.lastname: Asherin
authors.forename: Eugene
authors.initials: E
authors.lastname: Kronberg
authors.forename: Peter D
authors.initials: PD
authors.lastname: Teale
authors.forename: Martin L
authors.initials: ML
authors.lastname: Reite
authors.forename: Donald C
authors.initials: DC
authors.lastname: Rojas
mesh_terms: D000293:Adolescent; D058256:Brain Waves / Q000502:physiology*; D002531:Cerebellum / Q000503:physiopathology*; D002648:Child; D005260:Female; D005385:Fingers; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009044:Motor Cortex / Q000503:physiopathology*; D009068:Movement / Q000502:physiology*; D011618:Psychotic Disorders / Q000503:physiopathology*