title: Synthesis of 5-aryl-6-cinnamoyl-7-methyl-flavanones as novel antioxidants and antihyperlipidemics.
abstract: An economical and efficient one-pot synthesis of a series of novel 5-aryl-6-cinnamoyl-7-methyl-flavanones has been developed by simple refluxing of cinnamoyl chalcones with NaOAc in aqueous ethanol in quantitative yields. These flavanones were screened for their in vitro antioxidant and in vivo antidyslipidemic activities. Among 24 compounds screened, four compounds 28, 29, 30, and 48 showed significant antidyslipidemic activities. However, out of all the compounds, only compound 28 exhibited significant antioxidant activity and other compounds showed moderate antioxidant activities.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute Lucknow, CSIR, India.
authors.forename: Anindra
authors.initials: A
authors.lastname: Sharma
authors.forename: Namrata
authors.initials: N
authors.lastname: Anand
authors.forename: Rahul
authors.initials: R
authors.lastname: Sharma
authors.forename: Upma
authors.initials: U
authors.lastname: Chaturvedi
authors.forename: A K
authors.initials: AK
authors.lastname: Khanna
authors.forename: Gitika
authors.initials: G
authors.lastname: Bhatia
authors.forename: Rama P
authors.initials: RP
authors.lastname: Tripathi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D044950:Flavanones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: C573538:2-(4-bromophenyl)-6-(3-(4-bromophenyl)acryloyl)-7-methyl-5-phenylchroman-4-one; D000975:Antioxidants; D044950:Flavanones; D000960:Hypolipidemic Agents; D008055:Lipids