title: Peculiar distribution of tumorous xanthomas in an adult case of erdheim-chester disease complicated by atopic dermatitis.
abstract: Erdheim-Chester disease is a rare non-Langerhans form of histiocytosis with multiple organ involvement. Approximately 20% of patients have xanthoma-like lesions, usually on the eyelids. We report a case of Erdheim-Chester disease in a 32-year-old male who showed peculiar xanthomatous skin lesions and also had atopic dermatitis. His skin manifestations included ring-like yellowish tumors on his periorbital regions, rope necklace-like tumors on his neck, and spindle-shaped tumors on his right preauricular region and cubital fossas. He also had exophthalmos and diabetes insipidus. Chronic eczematous lesions were present on the flexor aspect of his extremities, and his serum eosinophil numbers and immunoglobulin E levels were elevated. A histological examination of his right neck tumor showed foamy macrophages and touton-type giant cells, which were positive for CD68 and CD163 and negative for S-100 and CD1a. We suggest that the complication of atopic dermatitis may have contributed to the uncommon clinical features in this case.
authors.affiliation: Department of Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Murakami
authors.forename: Mari
authors.initials: M
authors.lastname: Wataya-Kaneda
authors.forename: Mika
authors.initials: M
authors.lastname: Terao
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Azukizawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Murota
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nakata
authors.forename: Ichiro
authors.initials: I
authors.lastname: Katayama