title: Voriconazole-associated severe hyponatremia.
abstract: Voriconazole is the drug of choice for invasive aspergillosis. We describe three patients who presented with severe hyponatremia after the initiation of voriconazole treatment. One patient expired while the other two patients recovered after a dose adjustment or discontinuation of the antifungal. The voriconazole trough levels were checked in all and two were elevated. These findings mandate monitoring electrolyte levels during voriconazole therapy.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Kye-Hyung
authors.initials: KH
authors.lastname: Kim
authors.forename: Seunghwan
authors.initials: S
authors.lastname: Lee
authors.forename: Shinwon
authors.initials: S
authors.lastname: Lee
authors.forename: Na Ra
authors.initials: NR
authors.lastname: Yun
authors.forename: Nam Joong
authors.initials: NJ
authors.lastname: Kim
authors.forename: Kyung-Sang
authors.initials: KS
authors.lastname: Yu
authors.forename: In-Jin
authors.initials: IJ
authors.lastname: Jang
authors.forename: Wan Beom
authors.initials: WB
authors.lastname: Park
authors.forename: Myoung-Don
authors.initials: MD
authors.lastname: Oh
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D001228:Aspergillosis / Q000188:drug therapy; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D044967:Serum / Q000737:chemistry; D014230:Triazoles / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole