title: [Iron therapy: proof of efficacy and good clinical practice].
abstract: Efficacy of iron therapy, whether oral or intravenous, on biological markers of body iron stores is well recognized in medical literature, but current studies are heterogeneous, of sometimes dubious quality, and rarely address clinical outcomes. Precise practical guidelines appear available only for indications related to kidney disease. First-line intravenous use is reserved for situations comprising chronic renal failure, or patients presenting with malabsorption syndromes such as in inflammatory bowel disease. In all other situations, because of the non-negligible risk of hypersensitivity reactions, intravenous iron use is considered justified only in clinically sustained indications, for patients in whom oral administration of iron is unsatisfactory or impossible.
authors.affiliation: Division de pharmacologie et toxicologie cliniques, CHUV, 1011 Lausanne. Delphine.Renard@chuv.ch
authors.forename: Delphine
authors.initials: D
authors.lastname: Renard
authors.forename: Bernard
authors.initials: B
authors.lastname: Favrat
authors.forename: Françoise
authors.initials: F
authors.lastname: Livio
authors.forename: Thierry
authors.initials: T
authors.lastname: Buclin
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007501:Iron / Q000627:therapeutic use*; D014131:Trace Elements / Q000627:therapeutic use*
chemical_list: D014131:Trace Elements; D007501:Iron