title: A [Pd]-mediated ω-alkynone cycloisomerization approach for the central tetrahydropyran unit and the synthesis of C(31)-C(48) fragment of aflastatin A.
abstract: A concise assembly of the central tetrahydropyran unit of aflastatin A featuring a Pd-mediated alkynone cycloisomerization to provide a glycal and its subsequent stereoselective hydroboration to deliver the requisite stereochemistry at C(33) and C(34) centers is documented.
authors.affiliation: National Chemical Laboratory, Dr Homi Bhabha Road, Pune, 411 008, India.
authors.forename: Sachin B
authors.initials: SB
authors.lastname: Narute
authors.forename: Neella Chandra
authors.initials: NC
authors.lastname: Kiran
authors.forename: Chepuri V
authors.initials: CV
authors.lastname: Ramana
mesh_terms: D000480:Alkynes / Q000737:chemistry; D003500:Cyclization; D007536:Isomerism; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry*; D011760:Pyrrolidinones / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D011714:Pyrans; D011760:Pyrrolidinones; C105377:aflastatin A; D010165:Palladium