title: Polyoxygenated ergostane-type sterols from the liquid culture of Ganoderma applanatum.
abstract: A new polyoxygenated ergostane-type sterol, 3β,5α,6β,8β,14α-pentahydroxy-(22E,24R)-ergost-22-en-7-one (1), has been isolated from the liquid culture of the basidiomycete Ganoderma applanatum together with four known sterols, 3β,5α,9α-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (2), ergosterol peroxide (3), 6-dehydrocerevisterol (4) and cerevisterol (5). Two of these sterols (2, 4) are reported to have been isolated from this species for the first time. The structures of these compounds were determined by chemical and spectroscopic analyses, including 1D- and 2D-NMR, as well as by comparison of their spectroscopic data with those reported in the literature.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , 599 Daehak-dong, Gwanak-ro, Gwanak-gu, Seoul 151-742 , Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Ju Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
mesh_terms: D004875:Ergosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D032902:Ganoderma / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D010840:Phytosterols; D013256:Steroids; C006954:cerevisterol; C036071:ergosterol-5,8-peroxide; C015190:ergostane; D004875:Ergosterol