title: The possible roles of OPN-regulated CEACAM1 expression in promoting the survival of activated T cells and the apoptosis of oral keratinocytes in oral lichen planus patients.
abstract: Oral lichen planus is a chronic inflammatory disorder of the oral mucosa that represents T cell-mediated autoimmune diseases. The regulation and roles of carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1), a novel immune molecule, in the immunopathogenesis of T cell-mediated autoimmune diseases remain unclear. In the current paper, CEACAM1 was found to be overexpressed in peripheral T cells and epithelial cells in oral lichen planus patients. A fraction of infiltrating inflammatory mononuclear cells in the lamina propria of the oral lichen planus mucosa also expressed CEACAM1. Importantly, for the first time, CEACAM1 expression in T cells and in normal human oral keratinocytes was demonstrated to be regulated differently by osteopontin in vitro. Furthermore, the apoptosis of oral keratinocytes and activated T cells can be markedly suppressed by CEACAM1-specific monoclonal antibodies. In conclusion, OPN-regulated CEACAM1 expression may play a critical role in the immunopathogenesis of oral lichen planus.
authors.affiliation: Department of Pathology, Stomatology College of Shandong University, 44-1#, Wenhua Xi Road, Jinan, Shandong, 250012, People's Republic of China.
authors.forename: Gui-Xiang
authors.initials: GX
authors.lastname: Liu
authors.forename: Qi
authors.initials: Q
authors.lastname: Xie
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Zhou
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Zhang
authors.forename: Bo-Long
authors.initials: BL
authors.lastname: Ma
authors.forename: Cheng-Qin
authors.initials: CQ
authors.lastname: Wang
authors.forename: Feng-Cai
authors.initials: FC
authors.lastname: Wei
authors.forename: Xun
authors.initials: X
authors.lastname: Qu
authors.forename: Shan-Zhen
authors.initials: SZ
authors.lastname: Sun
mesh_terms: D000328:Adult; D019138:Antibodies, Blocking / Q000494:pharmacology; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D017209:Apoptosis / Q000187:drug effects; D015551:Autoimmunity; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D017676:Lichen Planus, Oral / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D053495:Osteopontin / Q000276:immunology / Q000494:pharmacology; D013280:Stomatitis; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D019138:Antibodies, Blocking; D015703:Antigens, CD; C069847:CD66 antigens; D015815:Cell Adhesion Molecules; D053495:Osteopontin