title: N-Acetylcysteine protects the peritoneum from the injury induced by hypertonic dialysis solution.
abstract: BACKGROUND
  Oxidative stress has been implicated in the development of peritoneal damage. The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) in a rat peritoneal infusion model.
  
  
  METHODS
  Eighteen male Wistar rats were divided in 3 groups: (i) control group; (ii) HDS group, receiving peritoneal dialysis solution (PDS); and (iii) HDS+NAC group, receiving PDS and oral NAC. Six weeks later they were evaluated for dialysate to plasma urea ratio (D/P), ratio of glucose concentration in peritoneal fluid (G1/G0), thiobarbituric acid reactive substances in plasma and urine and histology of peritoneal membrane.
  
  
  RESULTS
  The HDS+NAC group presented a lower increase in solute transport (D/P 0.51 ± 0.1, and G1/GO 0.35 ± 0.06) in comparison with the HDS group (D/P 0.67 ± 0.1; p=0.03, and G1/G0 0.27 ± 0.07; p=0.01). The HDS+NAC group showed lower thiobarbituric acid reactive substance concentrations compared with the HDS group. In the treated group, the peritoneal membrane presented lower thickness.
  
  
  CONCLUSIONS
  Functional and histological peritoneal changes were significantly reduced by the treatment with NAC.
authors.affiliation: Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Déborah S S
authors.initials: DS
authors.lastname: Bui
authors.forename: Antônio C
authors.initials: AC
authors.lastname: Seguro
authors.forename: Maria H
authors.initials: MH
authors.lastname: Shimitzu
authors.forename: Igor
authors.initials: I
authors.lastname: Schliemann
authors.forename: Dino
authors.initials: D
authors.lastname: Martini
authors.forename: João E
authors.initials: JE
authors.lastname: Romão
authors.forename: Roberto F
authors.initials: RF
authors.lastname: Pecoits Filho
authors.forename: Hugo
authors.initials: H
authors.lastname: Abensur
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D015314:Dialysis Solutions / Q000009:adverse effects*; D005947:Glucose / Q000032:analysis; D005950:Glucose Solution, Hypertonic / Q000009:adverse effects* / Q000737:chemistry; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010537:Peritoneum / Q000473:pathology* / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014508:Urea / Q000097:blood
chemical_list: D015314:Dialysis Solutions; D005950:Glucose Solution, Hypertonic; D017392:Thiobarbituric Acid Reactive Substances; D014508:Urea; D005947:Glucose; D000111:Acetylcysteine