title: Functional integration of membrane proteins with nanotube and nanowire transistor devices.
abstract: Biological molecules perform a sophisticated array of transport and signaling functions that rival anything that the modern electronics industry can create. Incorporating such building blocks into nanoelectronic devices could enable new generations of electronic circuits that use biomimetics to perform complicated tasks. Such types of circuits could ultimately blur the interface between living biological organisms and synthetic structures. Our laboratory has recently developed a versatile and flexible platform for integrating ion channels and pumps into single-walled carbon nanotube (SWNT) and silicon nanowire (SiNW) transistor devices, in which membrane proteins are embedded in a lipid bilayer shell covering the nanotube or nanowire component. In this chapter, we provide details for the fabrication of these devices and outline procedures for incorporating biological molecules into them. In addition, we also provide several examples of the use of these devices to couple biological transport to electronic signaling.
authors.affiliation: School of Natural Sciences, University of California, Merced, CA, USA. anoy@ucmerced.edu
authors.forename: Aleksandr
authors.initials: A
authors.lastname: Noy
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Artyukhin
authors.forename: Shih-Chieh
authors.initials: SC
authors.lastname: Huang
authors.forename: Julio A
authors.initials: JA
authors.lastname: Martinez
authors.forename: Nipun
authors.initials: N
authors.lastname: Misra
mesh_terms: D000408:Alamethicin / Q000737:chemistry / Q000378:metabolism; D004553:Electric Conductivity; D004563:Electrochemistry; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism; D006096:Gramicidin / Q000737:chemistry / Q000378:metabolism; D006460:Hemolysin Proteins / Q000737:chemistry / Q000378:metabolism; D017136:Ion Transport; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism*; D036103:Nanotechnology / Q000295:instrumentation*; D043942:Nanotubes / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry; D053770:Nanowires / Q000737:chemistry*; D016062:Porosity; D012825:Silicon / Q000737:chemistry; D014173:Transistors, Electronic; D014835:Volatilization
chemical_list: D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins; C036507:Hlya protein, E coli; D008051:Lipid Bilayers; D008565:Membrane Proteins; D037742:Nanotubes, Carbon; D006096:Gramicidin; D000408:Alamethicin; D012825:Silicon