title: Loxin polymorphism is associated with increased resistin levels and with oxidative status.
abstract: OBJECTIVE
  We hypothesized that LOX-1 polymorphism may impact on inflammation and cardiovascular risk by modulating systemic resistin expression.
  
  
  METHODS
  276 men were randomly selected from a population-based cohort. Metabolic and inflammatory markers were evaluated at baseline and after 6-years follow-up, OLR1 (loxin) IVS4-14 A>G polymorphism was assessed.
  
  
  RESULTS
  Mean plasma resistin and nitrotyrosine values were significantly higher, and TAS was significantly lowered in homozygous for the G allele. The G allele was significantly and directly associated with resistin and nitrotyrosine values.
  
  
  CONCLUSIONS
  Enhanced oxidized-LDL uptake by LOX-1 G-allele carriers is associated with increased pro-oxidant status and resistin levels, suggesting a major uptake of ox-LDL by macrophages, smooth muscle cells, and monocytes.
authors.affiliation: Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, Italy. roberto.gambino@unito.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambino
authors.forename: Simona
authors.initials: S
authors.lastname: Bo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Musso
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Pagano
authors.forename: Maurizio
authors.initials: M
authors.lastname: Cassader
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D016207:Cytokines / Q000378:metabolism; D005787:Gene Frequency; D006720:Homozygote; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D052243:Resistin / Q000097:blood* / Q000235:genetics; D051127:Scavenger Receptors, Class E / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D014443:Tyrosine / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D000975:Antioxidants; D008076:Cholesterol, HDL; D016207:Cytokines; D008077:Lipoproteins, LDL; C495137:OLR1 protein, human; C499624:RETN protein, human; D052243:Resistin; D051127:Scavenger Receptors, Class E; D014280:Triglycerides; C002744:3-nitrotyrosine; D014443:Tyrosine; D002097:C-Reactive Protein