title: Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis.
abstract: It is widely accepted that specific human papillomavirus (HPV) types are the central etiologic agent of cervical carcinogenesis. However, a number of infected women do not develop invasive lesions, suggesting that other environmental and host factors may play decisive roles in the persistence of HPV infection and further malignant conversion of cervical epithelium. Although many previous reports have focused on HPV and environmental factors, the role of host susceptibility to cervical carcinogenesis is largely unknown. Here, we review the findings of genetic association studies in cervical carcinogenesis with special reference to polymorphisms of glutathione-S-transferase (GST) isoforms, p53 codon 72, murine double-minute 2 homolog (MDM2) gene promoter 309, and FAS gene promoter -670 together with HPV types including our recent research results.
authors.affiliation: Department of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagataku, Hyogo, Kobe 653-0838, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Nunobiki
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Ueda
authors.forename: Eisaku
authors.initials: E
authors.lastname: Toji
authors.forename: Michiko
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Akashi
authors.forename: Naomi
authors.initials: N
authors.lastname: Sato
authors.forename: Shinji
authors.initials: S
authors.lastname: Izuma
authors.forename: Kiyo
authors.initials: K
authors.lastname: Torii
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tanaka
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Sadamu
authors.initials: S
authors.lastname: Noda