title: Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation.
abstract: A novel influenza A(H1N1)2009 variant with mildly reduced oseltamivir and zanamivir sensitivity has been detected in more than 10% of community specimens in Singapore and more than 30% of samples from northern Australia during the early months of 2011. The variant, which has also been detected in other regions of the Asia-Pacific, contains a S247N neuraminidase mutation. When combined with the H275Y mutation, as detected in an oseltamivir-treated patient, the dual S247N+H275Y mutant had extremely high oseltamivir resistance.
authors.affiliation: World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia. Aeron.Hurt@influenzacentre.org
authors.forename: A C
authors.initials: AC
authors.lastname: Hurt
authors.forename: R T
authors.initials: RT
authors.lastname: Lee
authors.forename: S K
authors.initials: SK
authors.lastname: Leang
authors.forename: L
authors.initials: L
authors.lastname: Cui
authors.forename: Y M
authors.initials: YM
authors.lastname: Deng
authors.forename: S P
authors.initials: SP
authors.lastname: Phuah
authors.forename: N
authors.initials: N
authors.lastname: Caldwell
authors.forename: K
authors.initials: K
authors.lastname: Freeman
authors.forename: N
authors.initials: N
authors.lastname: Komadina
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Speers
authors.forename: A
authors.initials: A
authors.lastname: Kelso
authors.forename: R T
authors.initials: RT
authors.lastname: Lin
authors.forename: S
authors.initials: S
authors.lastname: Maurer-Stroh
authors.forename: I G
authors.initials: IG
authors.lastname: Barr
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001315:Australia / Q000453:epidemiology; D004351:Drug Resistance / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D015994:Incidence; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics*; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000235:genetics*; D053139:Oseltamivir / Q000627:therapeutic use*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance / Q000379:methods; D018570:Risk Assessment; D012307:Risk Factors; D012846:Singapore / Q000453:epidemiology; D053243:Zanamivir / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase; D053243:Zanamivir