title: Effect of timing and duration of tamsulosin exposure on complications in resident-performed phacoemulsification.
abstract: OBJECTIVE
  Tamsulosin can cause intraoperative floppy iris syndrome and increase the risk of phacoemulsification complications. This study evaluated whether the risk of complications was associated with the timing or duration of preoperative tamsulosin exposure.
  
  
  METHODS
  The current study was a retrospective review of electronic medical records of resident-performed phacoemulsification surgeries from 1998 to 2008 at a Veterans Administration Hospital. There were 73 eyes with recent tamsulosin exposure (within 30 days preoperatively) and 28 eyes with remote exposure (> 30 days preoperatively but within 3 years of surgery).
  
  
  RESULTS
  There was a trend toward more total complications in recent compared with remote tamsulosin exposure cases (31.5% vs 14.3%, P = .09). A longer duration of tamsulosin use was not statistically associated with an increased risk of total complications.
  
  
  CONCLUSIONS
  The authors were unable to detect a statistically significant effect of duration of tamsulosin use on the risk of intraoperative complications in phacoemulsification surgery.
authors.affiliation: Department of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
authors.forename: Tina K
authors.initials: TK
authors.lastname: Ku
authors.forename: Ayman
authors.initials: A
authors.lastname: Naseri
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.forename: Travis C
authors.initials: TC
authors.lastname: Porco
authors.forename: Tina
authors.initials: T
authors.lastname: Rutar
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007396:Internship and Residency; D007431:Intraoperative Complications / Q000139:chemically induced*; D007499:Iris Diseases / Q000139:chemically induced*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000009:adverse effects*; D012189:Retrospective Studies; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*; D000077409:Tamsulosin; D013997:Time Factors
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin