title: Impact of moderate coronary atherosclerosis on long-term left ventricular remodeling after aortic valve replacemen.
abstract: BACKGROUND
  The role of coronary atherosclerosis (CA+) in ventricular remodeling after aortic valve replacement (AVR) for isolated aortic stenosis (AS) is not well defined. We sought to evaluate the impact of not revascularized moderate coronary atherosclerosis in long-term left ventricular (LV) remodeling after AVR.
  
  
  METHODS
  We assessed by coronariography the coronary artery disease in 66 patients referred for AVR and evaluated morphological and functional LV data by echocardiography both preoperatively and postoperatively (3 ± 1.2 years).
  
  
  RESULTS
  In patients without coronary atherosclerosis, hypertrophy regression was more intense and the absolute reverse remodeling was higher in LV mass index (-55.8 ± 36 g/m² vs -28.4 ± 34 g/m², p = 0.004), reduction of LV dimensions (LV end-diastolic diameter [LVEDD]: -4.1 ± 7.4 mm vs -2.2 ± 8.3 mm, p = 0.04), and regression of wall thickness (interventricular septum [IVS]: -3.3 ± 2.6 mm vs -1.6 ± 2.2 mm, p = 0.01; and posterior wall thickness [PWT]: -2.1 ± 2.1 mm vs 0.6 ± 2.1 mm, p = 0.012).
  
  
  CONCLUSIONS
  After AVR for AS, not revascularized moderate coronary atherosclerosis determines a long-term lesser degree of LV hypertrophy regression and a worse absolute reverse remodeling of LV mass index, LVEDD, IVS and PWT.
authors.affiliation: Department of Cardiology, Lozano Blesa University Clinic Hospital, Zaragoza, Spain. joselinares1979@hotmail.com
authors.forename: Jose Antonio Linares
authors.initials: JA
authors.lastname: Vicente
authors.forename: Isaac Lacambra
authors.initials: IL
authors.lastname: Blasco
authors.forename: Pilar Portero
authors.initials: PP
authors.lastname: Perez
authors.forename: Borja Simo
authors.initials: BS
authors.lastname: Sanchez
authors.forename: Maria Rosario Ortas
authors.initials: MR
authors.lastname: Nadal
authors.forename: Jose Ramón Ruiz
authors.initials: JR
authors.lastname: Arroyo
authors.forename: Mariano González
authors.initials: MG
authors.lastname: Carretero
authors.forename: Alfonso Del Rio
authors.initials: Adel R
authors.lastname: Ligorit
mesh_terms: D000368:Aged; D001022:Aortic Valve Insufficiency / Q000453:epidemiology* / Q000601:surgery*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D004452:Echocardiography; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D012720:Severity of Illness Index; D013995:Time; D020257:Ventricular Remodeling / Q000502:physiology*