title: Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient.
abstract: We report for the time a patient with recurrence of tubulointerstitial nephritis and uveitis (TINU) following renal transplantation. Our patient was diagnosed at the age of 8 years and, despite treatment with systemic steroids, developed established renal failure. At the age of 17 years, he underwent a live-related donor renal transplant. Immunosuppression included tacrolimus, mycophenolate mofetil and prednisolone. Having had normal renal function for 3 years after transplantation, he developed uveitis and decline in the graft function. A biopsy of the allograft demonstrated recurrent granulomatous interstitial nephritis. The recurrence of TINU following transplantation suggests a role for circulating autoantibodies in the disease pathology.
authors.affiliation: Department of Paediatric Nephrology, Royal Manchester Children’s Hospital, Manchester, UK.
authors.forename: Isioma
authors.initials: I
authors.lastname: Onyekpe
authors.forename: Mohan
authors.initials: M
authors.lastname: Shenoy
authors.forename: Helen
authors.initials: H
authors.lastname: Denley
authors.forename: Hany
authors.initials: H
authors.lastname: Riad
authors.forename: Nicholas J A
authors.initials: NJ
authors.lastname: Webb
mesh_terms: D001323:Autoantibodies / Q000097:blood; D002648:Child; D006801:Humans; D007166:Immunosuppressive Agents; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009395:Nephritis, Interstitial / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D012008:Recurrence; D013577:Syndrome; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014605:Uveitis / Q000150:complications* / Q000473:pathology / Q000628:therapy*
chemical_list: D001323:Autoantibodies; D007166:Immunosuppressive Agents