title: Persistent pulmonary hypertension of the newborn refractory to inhaled nitric oxide and prostacyclin, responsive to neuromuscular blockade.
abstract: Neonatal pulmonary hypertension refractory to high frequency ventilation (HFOV) and inhaled nitric oxide (iNO) is an occasional occurrence. We report a full-term neonate with severe pulmonary hypertension unresponsive to the treatment with HFOV and iNO, later associated with prostacyclin, who rapidly improved after the addition of vecuronium, a neuromuscular blocker.
authors.affiliation: Neonatal Intensive Care Unit, Department of Perinatal Medicine, A. Meyer University Children's Hospital, Florence, Italy. l.filippi@meyer.it
authors.forename: L
authors.initials: L
authors.lastname: Filippi
authors.forename: L
authors.initials: L
authors.lastname: Serafini
authors.forename: E
authors.initials: E
authors.lastname: Gozzini
authors.forename: C
authors.initials: C
authors.lastname: Poggi
authors.forename: M
authors.initials: M
authors.lastname: Moroni
authors.forename: P
authors.initials: P
authors.lastname: Fiorini
mesh_terms: D000280:Administration, Inhalation; D000959:Antihypertensive Agents / Q000627:therapeutic use; D011464:Epoprostenol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019148:Neuromuscular Blockade; D009569:Nitric Oxide / Q000008:administration & dosage; D010547:Persistent Fetal Circulation Syndrome / Q000188:drug therapy / Q000628:therapy*; D017211:Treatment Failure
chemical_list: D000959:Antihypertensive Agents; D009569:Nitric Oxide; D011464:Epoprostenol