title: Simulation and experimental studies on magnetic hyperthermia with use of superparamagnetic iron oxide nanoparticles.
abstract: Our purpose of this study was to present simulation and experimental studies on magnetic hyperthermia (MH) with use of an alternating magnetic field (AMF) and superparamagnetic iron oxide nanoparticles (Resovist®). In the simulation studies, the energy dissipation (P) and temperature rise rate (∆T/∆t) were computed under various conditions by use of the probability density function of the particle size distribution based on a log-normal distribution. P and ∆T/∆t and their dependence on the frequency of the AMF (f) largely depended on the particle size of Resovist®. P and ∆T/∆t reached maximum at a diameter of ~24 nm, and were proportional to the amplitude of the AMF (H (0)) raised to a power of ~2.0. In the experimental studies, we made a device for generating an AMF, and measured the temperature rise under various concentrations of Resovist®, H (0), and f. The temperature rise at 10 min after the start of heating was linearly proportional to the concentration of Resovist®, and proportional to H (0) raised to a power of ~2.4, which was slightly greater than that expected from the simulation studies. There was a tendency for the temperature rise to saturate with increasing f. In conclusion, this study will be useful for investigating the feasibility of MH with Resovist® and optimizing the parameters for it.
authors.affiliation: Division of Medical Technology and Science, Faculty of Health Science, Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, Japan. murase@sahs.med.osaka-u.ac.jp
authors.forename: Kenya
authors.initials: K
authors.lastname: Murase
authors.forename: Junko
authors.initials: J
authors.lastname: Oonoki
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Takata
authors.forename: Ruixiao
authors.initials: R
authors.lastname: Song
authors.forename: Anggia
authors.initials: A
authors.lastname: Angraini
authors.forename: Prapan
authors.initials: P
authors.lastname: Ausanai
authors.forename: Taro
authors.initials: T
authors.lastname: Matsushita
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003911:Dextrans; D004574:Electromagnetic Fields; D005290:Ferric Compounds / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods*; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission / Q000379:methods; D010316:Particle Size; D013696:Temperature; D013997:Time Factors
chemical_list: D003911:Dextrans; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; C065507:ferumoxides