title: SWI/SNF chromatin remodeling complex: a new cofactor in reprogramming.
abstract: Induced pluripotent stem (iPS) cells can be derived from somatic cells. Four key factors are required in this process including Oct4, Sox2, Klf4 and c-Myc. Ectopic expression of these four factors in somatic cells leads to reprogramming. Recent studies show that the SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling complex plays critical roles in reprogramming of somatic cells and maintaining the pluripotency of stem cells. The possible mechanism is that SWI/SNF enhances the binding activity of reprogramming factors to pluripotent gene promoters and thus increases the reprogramming efficiency. Here, we review these recent advances and discuss how SWI/SNF plays a role in reprogramming. Understanding this mechanism will be helpful to find out the detail of reprogramming, which may provide a new therapy in medical science by generating patient-specific pluripotent stem cells.
authors.affiliation: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
authors.forename: Ling
authors.initials: L
authors.lastname: He
authors.forename: Huan
authors.initials: H
authors.lastname: Liu
authors.forename: Liling
authors.initials: L
authors.lastname: Tang
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism / Q000502:physiology; D006801:Humans; D000090062:Kruppel-Like Factor 4; D035683:MicroRNAs / Q000378:metabolism / Q000502:physiology; D046912:Multiprotein Complexes / Q000378:metabolism / Q000502:physiology*; D034622:RNA Interference; D013234:Stem Cells / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology
chemical_list: D002868:Chromosomal Proteins, Non-Histone; C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D035683:MicroRNAs; D046912:Multiprotein Complexes; D014157:Transcription Factors