title: Association of transforming growth factor-β1 gene C-509T and T869C polymorphisms with atherosclerotic cerebral infarction in the Chinese: a case-control study.
abstract: BACKGROUND
  Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine involved in inflammation and pathogenesis of atherosclerosis. There is scant information on the relation between variations within the TGF-β1 gene polymorphisms and risks of ischemic cerebrovascular diseases. Therefore, this case-controlled study was carried out to investigate the possible association of the TGF-β1 gene C-509T and T869C polymorphisms, and their combined genotypes with the risk of atherosclerotic cerebral infarction (CI) in the Chinese population.
  
  
  RESULTS
  We recruited 164 CI patients and 167 healthy control subjects who were frequency-matched for age and gender. The frequencies of the -509TT genotype and T allele gene were significantly higher in the CI group (P = 0.007, P = 0.006). The frequencies of +869CC genotype and C allele were higher in the CI group (P = 0.002, P = 0.004). In the CI group, the individuals with -509TT genotype had a significantly higher level of plasma triglyceride (TG) (P = 0.017). +869CC genotype correlated significantly with higher level of plasma low density lipoprotein cholesterol (LDL-c) in the CI group (P = 0.015). With haplotype analysis, the frequency of the -509T/+869C combined genotype was significantly higher in the CI group than in controls (P < 0.001).
  
  
  CONCLUSIONS
  Our study suggests that C-509T and T869C gene polymorphisms in TGF-β1 may be a critical risk factor of genetic susceptibility to CI in the Chinese population.
authors.affiliation: Institute of Neurosciences, The Second Affiliated Hospital of Guangzhou Medical College, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou 510260, P.R. China.
authors.forename: Zhongxing
authors.initials: Z
authors.lastname: Peng
authors.forename: Lixuan
authors.initials: L
authors.lastname: Zhan
authors.forename: Shengqiang
authors.initials: S
authors.lastname: Chen
authors.forename: En
authors.initials: E
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D050197:Atherosclerosis / Q000097:blood / Q000150:complications* / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000097:blood / Q000150:complications / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; D014280:Triglycerides; D002784:Cholesterol