title: Osteogenic growth peptide accelerates bone healing during distraction osteogenesis in rabbit tibia.
abstract: Distraction osteogenesis is a valuable treatment method that allows limb lengthening or reconstruction of large bone defects. However, its major disadvantage is the long period required for the consolidation of a distraction callus. Osteogenic growth peptide (OGP) stimulates endochondral bone formation in fracture callus, but its capacity to promote regenerate ossification during distraction osteogenesis has not been evaluated. This study investigated whether intravenously administered OGP accelerated bone healing during distraction osteogenesis in 36 male New Zealand White rabbits, randomized into two groups. The treatment group received OGP (200 ng/kg body weight) in phosphate-buffered saline (PBS), intravenously, each day; the control group received PBS alone. A 15-mm lengthening of the right lower leg was performed using the method of Ilizarov. Evidence from biomechanical, histological and radiographic evaluations demonstrated that systemic OGP treatment promoted optimal new bone formation during distraction osteogenesis in this rabbit model.
authors.affiliation: Department of Orthopaedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Zhao
authors.forename: L
authors.initials: L
authors.lastname: Shao
authors.forename: H-M
authors.initials: HM
authors.lastname: Zhao
authors.forename: Z-H
authors.initials: ZH
authors.lastname: Zhong
authors.forename: J-Y
authors.initials: JY
authors.lastname: Liu
authors.forename: C-G
authors.initials: CG
authors.lastname: Hao
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000187:drug effects; D005360:Fibula / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery; D006657:Histones / Q000494:pharmacology*; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects; D019857:Osteogenesis, Distraction; D011182:Postoperative Care; D011817:Rabbits; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D054159:Torsion, Mechanical; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D006657:Histones; D036341:Intercellular Signaling Peptides and Proteins; C074533:osteogenic growth peptide