title: Podophyllotoxin-derived insecticidal agents: part XIII--evaluation of insecticidal activity of podophyllotoxin derivatives against Brontispa longissima.
abstract: In an attempt to find the biorational insecticides for Brontispa longissima control, 12 podophyllotoxin (PPT) analogues were tested for their insecticidal activity against the fifth-instar larvae of B. longissima in vivo for the first time. Among all the tested compounds, especially compounds 6 and 8 showed more promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia azedarach. The different insecticidal activity range of compounds 1-12 indicated that the variation of chemical structures in the PPT skeleton markedly affected the activity profiles of this compound class, and some important structure-activity relationship information has been revealed. Together, these preliminary results may be useful in guiding further modification of PPTs in the development of potential new insecticides.
authors.affiliation: MOE Key Laboratory of Arid and Grassland Ecology, School of Life Sciences, Lanzhou University, Lanzhou 730000, P.R. China.
authors.forename: Ying-Qian
authors.initials: YQ
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.lastname: Jing-Zhang
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Li
mesh_terms: D000818:Animals; D001517:Coleoptera / Q000187:drug effects*; D029779:Cupressaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology; D007814:Larva / Q000187:drug effects*; D011034:Podophyllotoxin / Q000031:analogs & derivatives / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014315:Triterpenes
chemical_list: D004365:Drugs, Chinese Herbal; D007306:Insecticides; D011034:Podophyllotoxin; C036454:toosendanin; D014315:Triterpenes