title: Asymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocenters.
abstract: A versatile methodology for the asymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocenters has been developed that relies on a series of Evans' aldol, hydroxyl-directed cyclopropanation, methanolysis, and Hg(II) mediated cyclopropane ring-opening reactions for stereocontrol.
authors.affiliation: Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Peed
authors.forename: Ignacio Periñán
authors.initials: IP
authors.lastname: Domínguez
authors.forename: Iwan R
authors.initials: IR
authors.lastname: Davies
authors.forename: Matt
authors.initials: M
authors.lastname: Cheeseman
authors.forename: James E
authors.initials: JE
authors.lastname: Taylor
authors.forename: Gabriele
authors.initials: G
authors.lastname: Kociok-Köhn
authors.forename: Steven D
authors.initials: SD
authors.lastname: Bull
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D003521:Cyclopropanes / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008628:Mercury / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D003521:Cyclopropanes; D007783:Lactones; C523059:prelactone B; D008628:Mercury