title: Resting state cortical electroencephalographic rhythms and white matter vascular lesions in subjects with Alzheimer's disease: an Italian multicenter study.
abstract: Resting state electroencephalographic (EEG) rhythms do not deteriorate with the increase of white matter vascular lesion in amnesic mild cognitive impairment (MCI) subjects [1], although white matter is impaired along Alzheimer's disease (AD). Here we tested whether this is true even in AD subjects. Closed-eye resting state EEG data were recorded in 40 healthy elderly (Nold), 96 amnesic MCI, and 83 AD subjects. White matter vascular lesions were indexed by magnetic resonance imaging recorded in the MCI and AD subjects (about 42% of cases following ADNI standards). The MCI subjects were divided into two sub-groups based on the median of the white matter lesion, namely MCI+ (people with highest vascular load; n = 48) and MCI- (people with lowest vascular load; n = 48). The same was true for the AD subjects (AD+, n = 42; AD-, n = 41). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30-40 Hz). LORETA software estimated cortical EEG sources. When compared to Nold group, MCI and AD groups showed well known abnormalities of delta and alpha sources. Furthermore, amplitude of occipital, temporal, and limbic alpha 1 sources were higher in MCI+ than MCI- group. As a novelty, amplitude of occipital delta sources was lower in AD+ than AD- group. Furthermore, central, parietal, occipital, temporal, and limbic alpha sources were higher in amplitude in AD+ than AD- group. Amplitude of these sources was correlated to global cognitive status (i.e., Mini Mental State Evaluation score). These results suggest that in amnesic MCI and AD subjects, resting state posterior delta and alpha EEG rhythms do not deteriorate with the increase of white-matter vascular lesion. These rhythms might be more sensitive to AD neurodegenerative processes and cognitive status rather than to concomitant lesions to white matter.
authors.affiliation: Department of Biomedical Sciences, University of Foggia, Foggia, Italy Department of Imaging, SAN RAFFAELE Cassino, Italy. c.babiloni@unifg.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.forename: Roberta
authors.initials: R
authors.lastname: Lizio
authors.forename: Filippo
authors.initials: F
authors.lastname: Carducci
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vecchio
authors.forename: Alberto
authors.initials: A
authors.lastname: Redolfi
authors.forename: Silvia
authors.initials: S
authors.lastname: Marino
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Tedeschi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Montella
authors.forename: Antonio
authors.initials: A
authors.lastname: Guizzaro
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Esposito
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bozzao
authors.forename: Franco
authors.initials: F
authors.lastname: Giubilei
authors.forename: Francesco
authors.initials: F
authors.lastname: Orzi
authors.forename: Carlo C
authors.initials: CC
authors.lastname: Quattrocchi
authors.forename: Andrea
authors.initials: A
authors.lastname: Soricelli
authors.forename: Elena
authors.initials: E
authors.lastname: Salvatore
authors.forename: Annalisa
authors.initials: A
authors.lastname: Baglieri
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
authors.forename: Enrica
authors.initials: E
authors.lastname: Cavedo
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ferri
authors.forename: Filomena
authors.initials: F
authors.lastname: Cosentino
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Ferrara
authors.forename: Ciro
authors.initials: C
authors.lastname: Mundi
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Grilli
authors.forename: Silvia
authors.initials: S
authors.lastname: Pugliese
authors.forename: Gianluca
authors.initials: G
authors.lastname: Gerardi
authors.forename: Laura
authors.initials: L
authors.lastname: Parisi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vernieri
authors.forename: Antonio I
authors.initials: AI
authors.lastname: Triggiani
authors.forename: Jan T
authors.initials: JT
authors.lastname: Pedersen
authors.forename: Hans-Göran
authors.initials: HG
authors.lastname: Hårdemark
authors.forename: Paolo M
authors.initials: PM
authors.lastname: Rossini
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Frisoni
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007558:Italy; D008279:Magnetic Resonance Imaging; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000502:physiology*; D009483:Neuropsychological Tests