title: [Exhaled nitric oxide in patients with esophagitis].
abstract: BACKGROUND
  Assessment of nitric oxide (NO) concentration in exhaled air is broadly used to monitor the airway inflammation in asthma. High level of NO are also observed in paranasal sinuses and gastrointestinal tract (GT). The intact esopahageal sphincters are responsible for maintain the NO within the GT. It is not known how much the GT and especially esophageal motility disorders can affect the FeNO measurements. The aim of the study was to assess if the gastroesophageal reflux disease has any impact on level of NO in exhaled air in patients who do not suffer from any airway disease.
  
  
  METHODS
  In 51 patients, in whom asthma, nasal polyps or atopy were excluded, gastroscopy with biopsy was performed. In 13 of them no esophageal pathology was found and they were considered as the control group. In the other 38 patients the esophagitis was diagnosed based on Los Angeles classification.
  
  
  RESULTS
  The concentration of NO in exhaled air in patients with endoscopical gastro-esophageal changes did not differ significantly from the NO concentration in patients without inflammatory changes in stomach and esophagus (p = 0.68). Moreover, the presence of hiatal hernia did not affect the FeNO (p = 0.67). There was also no significant dependence between NO level and infection with Helicobacter pylori (p = 0.18).
  
  
  CONCLUSIONS
  The gastroesophageal pathologies did not significantly affect NO concentration in exhaled air.
authors.affiliation: Klinika Chorób Wewnętrznych, Geriatrii i Alergologii we Wrocławiu, ul. Traugutta 57–59, Wrocław. dor_anna@yahoo.co.uk
authors.forename: Anna
authors.initials: A
authors.lastname: Dor-Wojnarowska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Liebhart
authors.forename: Marcin
authors.initials: M
authors.lastname: Grabowski
authors.forename: Leszek
authors.initials: L
authors.lastname: Czapla
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Grabowski
authors.forename: Bernard
authors.initials: B
authors.lastname: Panaszek
mesh_terms: D000328:Adult; D001944:Breath Tests; D004941:Esophagitis / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis* / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide