title: Non-cirrhotic portal hypertension in HIV-infected individuals.
abstract: Non-cirrhotic portal hypertension (NCPH) has been associated with didanosine (ddI) exposure. We aimed to determine the number of individuals with NCPH within our cohort and define their characteristics. We identified individuals within our cohort with NCPH and performed a retrospective case note review. Cumulative antiretroviral therapy (ART) use was calculated and a statistical analysis performed to compare exposure to the rest of the clinic cohort for the same time period. Where available, data was collated on FibroScan®, echocardiography and coagulation profile. Seventeen patients were identified. Upper gastrointestinal bleeding was the most common presenting feature. Liver biopsy showed mild portal or periportal fibrosis in 13 (81%) and four with features of nodular regenerative hyperplasia. There was significantly greater exposure to ddl in this group (59.5 months) compared to the rest of the HIV cohort (21.1 months) P = <0.001. Eleven subjects has a liver elastography performed, six (55%) had a result greater than 9.6 kPa (consistent with greater than F2 disease by Metavir scoring). Echocardiography was performed in seven patients: four met criteria for pulmonary hypertension. This is consistent with other cohorts demonstrating an association between the didanosine exposure and NCPH. Our data also suggest an increased risk of pulmonary hypertension.
authors.affiliation: Department of HIV Medicine, Chelsea and Westminster Hospital, London, UK. andrew.scourfield@chelwest.nhs.uk
authors.forename: A
authors.initials: A
authors.lastname: Scourfield
authors.forename: L
authors.initials: L
authors.lastname: Waters
authors.forename: P
authors.initials: P
authors.lastname: Holmes
authors.forename: G
authors.initials: G
authors.lastname: Panos
authors.forename: P
authors.initials: P
authors.lastname: Randell
authors.forename: A
authors.initials: A
authors.lastname: Jackson
authors.forename: S
authors.initials: S
authors.lastname: Mandalia
authors.forename: B
authors.initials: B
authors.lastname: Gazzard
authors.forename: M
authors.initials: M
authors.lastname: Nelson
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015331:Cohort Studies; D016049:Didanosine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000453:epidemiology / Q000821:virology; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D006975:Hypertension, Portal / Q000139:chemically induced / Q000453:epidemiology* / Q000821:virology; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000453:epidemiology / Q000821:virology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D019380:Anti-HIV Agents; D016049:Didanosine