title: Comparison of selective laser trabeculoplasty success in patients treated with either prostaglandin or timolol/dorzolamide fixed combination.
abstract: OBJECTIVE
  The purpose of this study was to compare the efficacy of selective laser trabeculoplasty (SLT) in eyes of patients with open-angle glaucoma receiving either a prostaglandin (PG) analog or a timolol/dorzolamide fixed combination (TDFC).
  
  
  METHODS
  In this retrospective study, we analyzed 48 eyes of 35 patients who underwent SLT for open-angle glaucoma receiving either a PG analog (n=20) or a TDFC (n=28). Mean decrease in intraocular pressure (IOP) and success rates were compared between patients treated with PG and those treated with TDFC. Success was defined as an IOP reduction of at least 20% at postoperative 1 year.
  
  
  RESULTS
  The mean decrease in IOP in eyes treated with PG and in eyes treated with TDFC were 4.1±3.1 and 4.6±3.5 at 1 week (P=0.579), 5.3±3.4 and 5.7±2.0 at 1 month (P=0.485), 5.2±3.1 and 5.5±2.5 at 3 months (P=0.271), 5.0±3.1 and 6.1±2.5 and at 6 months (P=0.044), and 4.7±3.1 and 6.5±2.9 at 1 year (P=0.017), respectively. The success rate at postoperative 1 year was 50.0% (standard deviation±16) in eyes receiving PG and 78.6% (standard deviation:±11) in eyes receiving TDFC (P=0.041).
  
  
  CONCLUSIONS
  This study shows that the SLT seems to be more effective in TDFC users than PG analog users.
authors.affiliation: Beyoglu Eye Research and Education Hospital, Istanbul, Turkey. dr.necipkara@gmail.com
authors.forename: Necip
authors.initials: N
authors.lastname: Kara
authors.forename: Cigdem
authors.initials: C
authors.lastname: Altan
authors.forename: Banu
authors.initials: B
authors.lastname: Satana
authors.forename: Hasan
authors.initials: H
authors.lastname: Altinkaynak
authors.forename: Ercument
authors.initials: E
authors.lastname: Bozkurt
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirok
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Yilmaz
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D053685:Laser Therapy / Q000379:methods; D008297:Male; D008875:Middle Aged; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D013449:Sulfonamides / Q000008:administration & dosage / Q000627:therapeutic use*; D013876:Thiophenes / Q000008:administration & dosage / Q000627:therapeutic use*; D013999:Timolol / Q000008:administration & dosage / Q000627:therapeutic use*; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D011465:Prostaglandins, Synthetic; D013449:Sulfonamides; D013876:Thiophenes; C479140:dorzolamide-timolol combination; D013999:Timolol