title: Treating the periphery to ameliorate neurodegenerative diseases.
abstract: Abnormalities in the kynurenine pathway are associated with neurodegenerative disorders. Zwilling et al. (2011) show that inhibition of kynurenine 3-monooxygenase in the body's periphery leads to an increase in kyneuric acid, a neuroprotective compound, in the brain. This intervention ameliorates neurodegeneration in mouse models of Alzheimer's disease and Huntington's disease.
authors.affiliation: Proteostasis Therapeutics, Inc., 200 Technology Square, Suite 402, Cambridge, MA 02139, USA.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Reinhart
authors.forename: Jeffery W
authors.initials: JW
authors.lastname: Kelly