title: Quality of vision after femtosecond laser-assisted descemet stripping endothelial keratoplasty and penetrating keratoplasty: a randomized, multicenter clinical trial.
abstract: OBJECTIVE
  To compare the quality of vision (straylight and contrast sensitivity) after femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS DSEK) and penetrating keratoplasty (PK).
  
  
  METHODS
  Prospective, randomized clinical trial.
  
  
  METHODS
  setting: Multicenter (5 ophthalmic centers in The Netherlands). study population: Eighty eyes of 80 patients with corneal endothelial dysfunction were included and were randomized to FS DSEK or PK. observation procedures: FS DSEK and PK. main outcome measures: Straylight, contrast sensitivity, astigmatism, uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), and visual symptom score.
  
  
  RESULTS
  Straylight at 12 months was 1.37 ± 0.2 logarithm of straylight for FS DSEK and 1.46 ± 0.2 logarithm of straylight for PK (P = .151). During 12 months of follow-up, there was a significant improvement of straylight and contrast sensitivity after FS DSEK (P < .001) and PK (P < .001). The change of straylight and contrast sensitivity correlated significantly with the change of BSCVA after FS DSEK (r = -0.645; r = 0.580) and PK (r = -0.370; r = 0.659). The visual symptom score was comparable between the 2 groups during the 12 months of follow-up.
  
  
  CONCLUSIONS
  Improvement of straylight and contrast sensitivity was significantly correlated with an improvement of BSCVA. Straylight and contrast sensitivity were improved significantly after FS DSEK and were comparable with those after PK, although BSCVA was slightly better in the PK group.
authors.affiliation: Department of Ophthalmology, Maastricht University Medical Centre, The Netherlands. y.cheng@mumc.nl
authors.forename: Yanny Y Y
authors.initials: YY
authors.lastname: Cheng
authors.forename: Tom J T P
authors.initials: TJ
authors.lastname: van den Berg
authors.forename: Jan S
authors.initials: JS
authors.lastname: Schouten
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Pels
authors.forename: Robert-Jan
authors.initials: RJ
authors.lastname: Wijdh
authors.forename: Hugo
authors.initials: H
authors.lastname: van Cleynenbreugel
authors.forename: Catharina A
authors.initials: CA
authors.lastname: Eggink
authors.forename: Wilhelmina J
authors.initials: WJ
authors.lastname: Rijneveld
authors.forename: Rudy M M A
authors.initials: RM
authors.lastname: Nuijts
mesh_terms: D000368:Aged; D001251:Astigmatism / Q000503:physiopathology; D002386:Cataract / Q000150:complications; D002387:Cataract Extraction; D015350:Contrast Sensitivity / Q000502:physiology*; D003316:Corneal Diseases / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D057111:Descemet Stripping Endothelial Keratoplasty; D005260:Female; D005500:Follow-Up Studies; D019466:Glare; D006801:Humans; D015948:Keratoplasty, Penetrating; D053685:Laser Therapy / Q000379:methods*; D019654:Lens Implantation, Intraocular; D008297:Male; D011446:Prospective Studies; D019984:Quality Indicators, Health Care; D012029:Refraction, Ocular / Q000502:physiology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome