title: [New insights in adult Still disease's knowledge].
abstract: BACKGROUND
  Adult Still's Disease has systemic consequences, an inflammatory origin and unknown etiology. Knowledge about this disease is still limited, but some evolution has occurred in the last few years.
  
  
  OBJECTIVE
  Using a clinical case as example, the purpose of this paper is to review actual knowledge about Adult Still's Disease, giving special relevance to the most recent findings.
  
  
  METHODS
  Search in Pubmed and Cochrane database (1970-2009) for the terms Adultonset Still's Disease for all available papers. Those considered clinically and historically relevant were selected. An additional search was done in scientific journals and textbooks and other web sites. The information was analysed, using a clinical case in an atypical age as illustration.
  
  
  RESULTS
  Adult Still's Disease as multiple manifestations, being fever, evanescent skin rash and arthralgia the most typical. Laboratorial parameters are inespecific, but high glycosilated ferritin is highly suggestive. Non-steroid anti-inflammatory, corticoids, immunosuppressors, and recent biological agents are used in treatment.
  
  
  CONCLUSIONS
  Being uncommon, actual knowledge about this disease is based in isolated descriptions or very short series. There are no specific guidelines, but diagnostic criteria have been improved in recent years, as have the insights in pathophysiology and therapeutic resources.
authors.affiliation: Serviço de Medicina, Hospital Distrital de Santarém, Portugal.
authors.forename: Nuno
authors.initials: N
authors.lastname: Cabanelas
authors.forename: Patrícia
authors.initials: P
authors.lastname: Ferreira
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Esteves
authors.forename: Fausto
authors.initials: F
authors.lastname: Roxo
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis*