title: In vivo cell death mediated by synthetic ion channels.
abstract: Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Smith
authors.forename: Megan M
authors.initials: MM
authors.lastname: Daschbach
authors.forename: Seth T
authors.initials: ST
authors.lastname: Gammon
authors.forename: Shuzhang
authors.initials: S
authors.lastname: Xiao
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Chapman
authors.forename: Caroline
authors.initials: C
authors.lastname: Hudson
authors.forename: Mark
authors.initials: M
authors.lastname: Suckow
authors.forename: David
authors.initials: D
authors.lastname: Piwnica-Worms
authors.forename: George W
authors.initials: GW
authors.lastname: Gokel
authors.forename: W Matthew
authors.initials: WM
authors.lastname: Leevy
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects*; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007267:Injections; D007473:Ion Channels / Q000378:metabolism*; D017136:Ion Transport / Q000187:drug effects; D051379:Mice
chemical_list: D007473:Ion Channels