title: Layer-by-layer assembled multilayer films of methoxypoly(ethylene glycol)-block-poly(α,l-glutamic acid) and chitosan with reduced cell adhesion.
abstract: A methoxypoly(ethylene glycol)-block-poly(α,L-glutamic acid) (mPEGGA) diblock copolymer is synthesized. Using QCM measurements, it is shown that (CS/mPEGGA)(n) film construction takes place over two build-up stages (exponential-to-linear). UV-vis spectra reveal the regular increase of the multilayer film growth at different molecular weights of mPEGGA. Contact angle and surface morphology investigation prove that the hydrophilicity of CS/mPEGGA multilayer film-modified substrate becomes better and the surface becomes rough. Significantly reduced cell adhesion is observed on the CS/mPEGGA multilayer film coated surface.
authors.affiliation: Department of Polymer Materials, Shanghai University, 20 Chengzhong Road, Jiading, Shanghai, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Cao
authors.forename: Shifeng
authors.initials: S
authors.lastname: Yan
authors.forename: Kunxi
authors.initials: K
authors.lastname: Zhang
authors.forename: Zhijiang
authors.initials: Z
authors.lastname: Song
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Cui
authors.forename: Jingbo
authors.initials: J
authors.lastname: Yin
mesh_terms: D002448:Cell Adhesion; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000737:chemistry; D018698:Glutamic Acid / Q000737:chemistry*; D008422:Materials Testing; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013234:Stem Cells / Q000166:cytology; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D011108:Polymers; D018698:Glutamic Acid; D011092:Polyethylene Glycols; D048271:Chitosan