title: [Effect of exogenous calcitonin gene-related Peptide on systemic arterial blood pressure in pregnant and non-pregnant rats].
abstract: It is known that in the process of gestation and delivery, jointly with well recognized regulatory factors such as sex steroids, catecholamines, oxytocin and prostaglandins the substances of peptidergic nature are also involved. One of these substances is a Calcitonin Gene-Related Peptide (CGRP). In experiments on groups of pregnant and non pregnant rats we have demonstrated that exogenous Calcitonin Gene-Related Peptide causes a decrease in mean systemic arterial pressure. Hypotensive effect of CGRP is due to dilation of blood vessels. CGRP exerts a dose-dependent hypotensive effect and this effect on pregnant rats significantly exceeds the effect, manifested in non-pregnant once.
authors.affiliation: Tbilisi State Medical University; P. Shotadze Tbilisi Medical Academy, Georgia.
authors.forename: E
authors.initials: E
authors.lastname: Sukhishvili
authors.forename: G
authors.initials: G
authors.lastname: Bekaia
authors.forename: I
authors.initials: I
authors.lastname: Kvachadze
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001808:Blood Vessels / Q000187:drug effects / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D011247:Pregnancy; D051381:Rats
chemical_list: D015740:Calcitonin Gene-Related Peptide