title: Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance.
abstract: Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance.
authors.affiliation: Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Hasbi
authors.forename: Brian F
authors.initials: BF
authors.lastname: O'Dowd
authors.forename: Susan R
authors.initials: SR
authors.lastname: George
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D006801:Humans; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2