title: Prognostic significance of Wnt-1, β-catenin and E-cadherin expression in advanced colorectal carcinoma.
abstract: Wnt/β-catenin pathway plays an important role in initiation and progression of colorectal oncogenesis. The aim of this study was to determine expression and localization of E-cadherin, β-catenin and Wnt-1 proteins in colorectal tumors. Expression of β-catenin, E-cadherin and Wnt-1 was determined by immunohistochemistry on advanced colorectal cancers. Abnormal expression of E-cadherin, β-catenin, Wnt-1 was observed. Additionally, we revealed correlations between levels of studied proteins and histoclinical data. In multivariate analysis nuclear β-catenin, higher carcinoembryonic antigen serum level before treatment, female sex and tumor localized in colon or rectum were independent unfavorable prognostic factors. These findings support the hypothesis that Wnt/β-catenin pathway plays an important role in advanced colorectal carcinoma.
authors.affiliation: Department of Medical Biotechnology, Medical University of Lodz, Lodz, Poland. aleksandra.stanczak@celonpharma.com
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Stanczak
authors.forename: Rafal
authors.initials: R
authors.lastname: Stec
authors.forename: Lubomir
authors.initials: L
authors.lastname: Bodnar
authors.forename: Wojciech
authors.initials: W
authors.lastname: Olszewski
authors.forename: Marzena
authors.initials: M
authors.lastname: Cichowicz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kozlowski
authors.forename: Cezary
authors.initials: C
authors.lastname: Szczylik
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Pietrucha
authors.forename: Maciej
authors.initials: M
authors.lastname: Wieczorek
authors.forename: Monika
authors.initials: M
authors.lastname: Lamparska-Przybysz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D051155:Wnt1 Protein / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D051176:beta Catenin / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism
chemical_list: C495270:CTNNB1 protein, human; D015820:Cadherins; D051155:Wnt1 Protein; D051176:beta Catenin