title: Enantioselective cyclization of 4-alkenoic acids via an oxidative allylic C-H esterification.
abstract: An enantioselective intramolecular oxidative cyclization of 4-alkenoic acids was developed. The reaction proceeded via a π-allyl Pd intermediate generated by an allylic C-H activation to give γ-lactone derivatives with moderate to good enantioselectivity. Spiro bis(isoxazoline) ligand, SPRIX, was indispensable for this asymmetric transformation.
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takenaka
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Akita
authors.forename: Yugo
authors.initials: Y
authors.lastname: Tanigaki
authors.forename: Shinobu
authors.initials: S
authors.lastname: Takizawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sasai