title: Refined information on alleles belonging to the C*07:01/07:06/07:18 group in the Korean population.
abstract: Alleles of the C*07:01/07:06/07:18 group is distinguished by polymorphisms in exons 5-6. In a previous study, we focused on exons 2-3 of the gene and showed that 6.8% of Koreans express alleles in this group. In this study, we identified allelic and haplotypic diversities of the C*07:01/07:06/07:18 group in Koreans. Among 118 C*07:01/07:06/07:18-positive, unrelated, healthy samples, 96.6% were C*07:06 and 3.4% were C*07:01. Each allele was exclusively associated with a specific set of other alleles consisting of the conserved haplotypes A*01:01-C*07:01-B*08:01-DRB1*03:01-DQB1*02:01 (100%) and A*33:03-C*07:06-B*44:03-DRB1*07:01-DQB1*02:02 (95.6%), respectively. None carried C*07:18. With the continuous discovery of novel alleles, periodic updates with testing for newer alleles will be useful to support related research and clinical settings in each population.
authors.affiliation: Hallym Institution for Genome Application, Hallym University, Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, Korea. leekw@hallym.or.kr
authors.forename: Kyung Wha
authors.initials: KW
authors.lastname: Lee
authors.forename: Young-A
authors.initials: YA
authors.lastname: Jung
mesh_terms: D000483:Alleles; D005006:Ethnicity; D005787:Gene Frequency; D060005:Genotyping Techniques; D015236:HLA-C Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006650:Histocompatibility Testing / Q000639:trends; D006801:Humans; D007723:Korea; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D015236:HLA-C Antigens