title: [Parapneumonic pleural effusion incidence in a French region before and during the antipneumococcal vaccine era].
abstract: OBJECTIVE
  The aim of the study was to compare the incidence of parapneumonic pleural effusion in the Limousin region of France, based on the comparison of pre- and postvaccination periods.
  
  
  METHODS
  Subjects, 0-18-years-old, were retrospectively identified by searching in computerized databases of coded discharge diagnosis for patients with a diagnosis of pleural effusion and/or empyema and/or pulmonary infection in all the pediatric departments in Limousin hospitals. Medical records were reviewed by one of the authors and those with parapneumonic effusion and confirmed or suspected pneumococcal infection were included in the study. Data from the children hospitalized for parapneumonic pleural effusion were collected for two periods: period A, from July 2000 to July 2006, and period B, from July 2006 to July 2009 (before and after the generalization of the antipneumococcal vaccination). The main endpoint was the number of parapneumonic pleural effusion cases in each period in order to calculate the incidence within each period.
  
  
  RESULTS
  A total of 35 children were included: nine during period A and 26 during period B. The incidence was 1 per 100,000 children for period A and 5.8 per 100,000 for period B. Bacteriological tests allowed us to serotype eight S. pneumoniae over the two periods. All serotypes were non-vaccine serotypes (1, 3, and 19A).
  
  
  CONCLUSIONS
  This study demonstrates the increase in parapneumonic pleural effusion in the Limousin region.
authors.affiliation: Service de pédiatrie, hôpital Mère-Enfant, CHU de Limoges, 8, rue Dominique-Larrey, 87000 Limoges, France. alexmass13@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Masson
authors.forename: C
authors.initials: C
authors.lastname: Ménetrey
authors.forename: F
authors.initials: F
authors.lastname: Garnier
authors.forename: C
authors.initials: C
authors.lastname: Bahans
authors.forename: A
authors.initials: A
authors.lastname: Fargeot
authors.forename: M
authors.initials: M
authors.lastname: Layadi
authors.forename: J-L
authors.initials: JL
authors.lastname: Soulier
authors.forename: V
authors.initials: V
authors.lastname: Guigonis
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France; D006801:Humans; D015994:Incidence; D008297:Male; D010996:Pleural Effusion / Q000453:epidemiology* / Q000382:microbiology; D022242:Pneumococcal Vaccines; D011018:Pneumonia, Pneumococcal / Q000150:complications / Q000453:epidemiology* / Q000517:prevention & control; D012189:Retrospective Studies
chemical_list: D022242:Pneumococcal Vaccines