title: [Structure, localizations and functions of chromosomal passenger complex].
abstract: Chromosomal passenger complex (CPC) is mainly composed of a protein kinase Aurora B, inner centromere protein, Survivin, and Borealin. As in different periods of cell division, CPC can localise correctly to relavent destinations in time and interact on its different substrates in the mitotic cell. CPC modulats phosphorylation of histone H3 in chromatin aggregation and controlls cohesion or segregation of sister chromatids. It is involved in assembly of a mitotic spindle and its chromosomes catched. Moreover, CPC corrects attachment errors between kinetochore and microtuble and gives faithfuly chromosomal segregation and promoting cytokinesis. Here, the structure compenants, localization on chromosomal arms, inner centromere and central spindle, and functions in defferent posisions of CPC were briefly descriped.
authors.affiliation: Department of Pathology, Nanjing Chinese Medical University, Nanjing 210029, China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Dai
authors.forename: Hui-Hua
authors.initials: HH
authors.lastname: Zheng
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000818:Animals; D064107:Aurora Kinase B; D064127:Aurora Kinases; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry* / Q000378:metabolism*; D002875:Chromosomes / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000378:metabolism; D021381:Protein Transport
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D046912:Multiprotein Complexes; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases