title: Antinociceptive activity of discretamine isolated from Duguetia moricandiana.
abstract: The phytochemical study of Duguetia moricandiana Mart. (Annonaceae) yielded the isolation of the alkaloid which was identified by spectral analysis as discretamine. The evaluation of antinociceptive activity carried out by the acetic acid-induced writhing, formalin and hot plate tests in mice, suggests a potent antinociceptive effect. Discretamine (5, 10 and 20 mg kg⁻¹, i.p.) significantly reduced the number of writhes similarly at all doses tested and the number of paw licks during the first phase of formalin test when compared to control. The effect of discretamine on hot plate response provides a confirmation of its central effect. These results indicate antinociceptive properties of this alkaloid.
authors.affiliation: Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205, Petrolina, Pernambuco, Brazil. jackson.guedes@univasf.edu.br
authors.forename: J R G S
authors.initials: JR
authors.lastname: Almeida
authors.forename: J T
authors.initials: JT
authors.lastname: de Lima
authors.forename: H R
authors.initials: HR
authors.lastname: de Oliveira
authors.forename: M R
authors.initials: MR
authors.lastname: de Oliveira
authors.forename: P R M
authors.initials: PR
authors.lastname: Meira
authors.forename: A S S C
authors.initials: AS
authors.lastname: Lúcio
authors.forename: J M
authors.initials: JM
authors.lastname: Barbosa Filho
authors.forename: L J
authors.initials: LJ
authors.lastname: Quintans Júnior
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D001600:Berberine Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D002845:Chromatography; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D000700:Analgesics; D001600:Berberine Alkaloids; D010936:Plant Extracts; D005557:Formaldehyde; C010941:discretamine; D019342:Acetic Acid