title: Preliminary evidence of the presence of lymphatic vessels immunoreactive for D2-40 and Prox-1 in human pterygium.
abstract: Human pterygium is a benign fibrovascular outgrowth of the corneo-conjunctival junction, characterized by tissue remodeling, cellular proliferation, angiogenesis and inflammation. No data are available concerning the presence of lymphatic vessels in this pathological condition. The aim of this study was to evaluate by immunohistochemistry, using antibodies against D2-40, Prox-1 and Ki-67, the presence and the proliferative activity of lymphatic vessels in human pterygium. An increased lymphatic microvessel density was observed in the human pterygium compared to the normal conjunctiva. Moreover, D2-40-positive lymphatic endothelial cells were also actively proliferating, as assessed by Ki-67 immunostaining, while in normal conjunctiva proliferating lymphatic endothelial cells were not detectable. Overall, these data clearly indicate the presence of active proliferating lymphatic vessels in human pterygium, suggesting that active lymphangiogenesis occurs in this pathological condition.
authors.affiliation: Department of Histology, Victor Babeş University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Anca Maria
authors.initials: AM
authors.lastname: Cimpean
authors.forename: Mihai
authors.initials: M
authors.lastname: Poenaru Sava
authors.forename: Marius
authors.initials: M
authors.lastname: Raica
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000378:metabolism*; D003228:Conjunctiva / Q000378:metabolism / Q000473:pathology; D005260:Female; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D042601:Lymphatic Vessels / Q000378:metabolism / Q000473:pathology*; D008297:Male; D011625:Pterygium / Q000378:metabolism / Q000473:pathology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D000098551:Prospero-Related Homeobox 1 Protein
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D018398:Homeodomain Proteins; D025521:Tumor Suppressor Proteins; C500987:monoclonal antibody D2-40; D000098551:Prospero-Related Homeobox 1 Protein