title: Post-irradiation "acquired cavernous angiomas" with drug resistant seizures.
abstract: Cavernomas are well-known congenital vascular lesions with presumably high epileptogenicity. We report two patients who developed cavernomas; both were in remission from childhood acute lymphoblastic leukemia following standard chemo-radiotherapy. They developed drug-resistant focal epilepsy secondary to cavernomas and were subjected to surgical/medical management. This report highlights the ictogenesis of radiation-induced "acquired" cavernous angiomatosis in the brain. Appropriate treatment, including resection of these lesions in selected cases, improves the quality of life in such patients.
authors.affiliation: R. Madhavan Nayar Center for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, India. rsnmenon@yahoo.com
authors.forename: Ramshekhar N
authors.initials: RN
authors.lastname: Menon
authors.forename: Neeraj N
authors.initials: NN
authors.lastname: Baheti
authors.forename: Ajith
authors.initials: A
authors.lastname: Cherian
authors.forename: Chaturbhuj
authors.initials: C
authors.lastname: Rathore
authors.forename: Rajesh S
authors.initials: RS
authors.lastname: Iyer
authors.forename: Ashalatha
authors.initials: A
authors.lastname: Radhakrishnan
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000209:etiology* / Q000601:surgery; D002648:Child; D004569:Electroencephalography; D006392:Hemangioma, Cavernous / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000532:radiotherapy; D011832:Radiation Injuries / Q000150:complications*; D012640:Seizures / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014741:Video Recording