title: Straightforward four-component access to spiroindolines.
abstract: Spiroindolines could be synthesized via a very convenient one-pot procedure combining a Ugi coupling and a new copper-catalyzed oxidative process at a peptidyl position. Due to the nature of the first step, this method offers a straightforward access to complex alkaloids with four points of molecular diversity.
authors.affiliation: UMR 7652 (Ecole Polytechnique/ENSTA/CNRS), Laboratoire Chimie et Procédés, Ecole Nationale Supérieure des Techniques Avancées, 32 Bd Victor, 75015 Paris, France. laurent.elkaim@ensta.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: El Kaïm
authors.forename: Laurence
authors.initials: L
authors.lastname: Grimaud
authors.forename: Xavier-Frédéric
authors.initials: XF
authors.lastname: Le Goff
authors.forename: Martha
authors.initials: M
authors.lastname: Menes-Arzate
authors.forename: Luis D
authors.initials: LD
authors.lastname: Miranda
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000480:Alkynes; D007211:Indoles; C057812:indoline; D003300:Copper