title: Serotonin transporter binding after recovery from bulimia nervosa.
abstract: OBJECTIVE
  Physiological and pharmacological studies indicate that altered brain serotonin (5-HT) activity could contribute to a susceptibility to develop appetitive and behavioral alterations that are characteristic of bulimia nervosa (BN).
  
  
  METHODS
  Eight individuals recovered from BN (REC BN) and eight healthy control women were scanned with [11C]DASB and positron emission tomography imaging of the 5-HT transporter (5-HTT). Logan graphical analysis was applied, and parametric binding potential (BP(nondisplaceable (ND)) ) images were generated. Voxel-by-voxel t-tests and a region of interest (ROI) analysis were conducted.
  
  
  RESULTS
  REC BN had significantly lower [11C]DASB BP(ND) in midbrain, superior and inferior cingulate and significantly higher [11C]DASB BP(ND) in anterior cingulate and superior temporal gyrus in the voxel-based analysis. ROI analysis indicated lower [11C]DASB BP(ND) in midbrain (p = .07), containing the dorsal raphe, in REC BN, consistent with our earlier studies.
  
  
  CONCLUSIONS
  These preliminary findings of a small-scale study confirm and extend previous data suggesting that ill and recovered BN have altered 5-HTT measures, which potentially contribute to BN symptomatology and/or differential responses to medication.
authors.affiliation: Department of Radiology, University of California, San Diego, California, USA.
authors.forename: Rama
authors.initials: R
authors.lastname: Pichika
authors.forename: Monte S
authors.initials: MS
authors.lastname: Buchsbaum
authors.forename: Ursula
authors.initials: U
authors.lastname: Bailer
authors.forename: Carl
authors.initials: C
authors.lastname: Hoh
authors.forename: Alex
authors.initials: A
authors.lastname: Decastro
authors.forename: Bradley R
authors.initials: BR
authors.lastname: Buchsbaum
authors.forename: Walter
authors.initials: W
authors.lastname: Kaye
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D052018:Bulimia Nervosa / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D011877:Radionuclide Imaging; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins