title: An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo.
authors.affiliation: Department of Chemistry and Biochemistry, 215 UCB, University of Colorado at Boulder, Boulder, CO 80309-0215, USA.
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Ghosh
authors.forename: Peter F
authors.initials: PF
authors.lastname: Slivka
authors.forename: Zeno
authors.initials: Z
authors.lastname: Fiorini
authors.forename: Mark R
authors.initials: MR
authors.lastname: Hutchinson
authors.forename: Linda R
authors.initials: LR
authors.lastname: Watkins
authors.forename: Hang
authors.initials: H
authors.lastname: Yin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001393:Azoles / Q000737:chemistry / Q000378:metabolism; D002460:Cell Line; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051218:Lymphocyte Antigen 96 / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D056004:Molecular Dynamics Simulation; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D009437:Neuralgia / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D009457:Neuroglia / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D009578:Nitrobenzenes / Q000737:chemistry / Q000378:metabolism; D059408:Pain Management / Q000379:methods*; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D051381:Rats; D013050:Spectrometry, Fluorescence; D037182:T-Cell Antigen Receptor Specificity; D051197:Toll-Like Receptor 4 / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*
chemical_list: C510797:7-nitrobenz-2-oxa-1,3-diazol-4-yl; D001393:Azoles; C495377:LY96 protein, human; D008070:Lipopolysaccharides; D051218:Lymphocyte Antigen 96; D009578:Nitrobenzenes; D010446:Peptide Fragments; D051197:Toll-Like Receptor 4