title: Measures of linkage disequilibrium among neighbouring SNPs indicate asymmetries across the house mouse hybrid zone.
abstract: Theory predicts that naturally occurring hybrid zones between genetically distinct taxa can move over space and time as a result of selection and/or demographic processes, with certain types of hybrid zones being more or less likely to move. Determining whether a hybrid zone is stationary or moving has important implications for understanding evolutionary processes affecting interactions in hybrid populations. However, direct observations of hybrid zone movement are difficult to make unless the zone is moving rapidly. Here, evidence for movement in the house mouse Mus musculus domesticus × Mus musculus musculus hybrid zone is provided using measures of LD and haplotype structure among neighbouring SNP markers from across the genome. Local populations of mice across two transects in Germany and the Czech Republic were sampled, and a total of 1301 mice were genotyped at 1401 markers from the nuclear genome. Empirical measures of LD provide evidence for extinction and (re)colonization in single populations and, together with simulations, suggest hybrid zone movement because of either geography-dependent asymmetrical dispersal or selection favouring one subspecies over the other.
authors.affiliation: Department of Ecology and Evolutionary Biology and Museum of Zoology, University of Michigan, Ann Arbor MI 48109, USA.
authors.forename: Liuyang
authors.initials: L
authors.lastname: Wang
authors.forename: Ken
authors.initials: K
authors.lastname: Luzynski
authors.forename: John E
authors.initials: JE
authors.lastname: Pool
authors.forename: Václav
authors.initials: V
authors.lastname: Janoušek
authors.forename: Petra
authors.initials: P
authors.lastname: Dufková
authors.forename: Martina M
authors.initials: MM
authors.lastname: Vyskočilová
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Teeter
authors.forename: Michael W
authors.initials: MW
authors.lastname: Nachman
authors.forename: Pavel
authors.initials: P
authors.lastname: Munclinger
authors.forename: Miloš
authors.initials: M
authors.lastname: Macholán
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Piálek
authors.forename: Priscilla K
authors.initials: PK
authors.lastname: Tucker
mesh_terms: D000818:Animals; D018153:Czech Republic; D005828:Genetics, Population; D060005:Genotyping Techniques; D005843:Geography; D005858:Germany; D006239:Haplotypes; D006824:Hybridization, Genetic; D015810:Linkage Disequilibrium; D051379:Mice / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA