title: The human heart releases cardiotrophin-1 after coronary artery bypass grafting with cardiopulmonary bypass.
abstract: OBJECTIVE
  Cardiotrophin-1 (CT-1) is closely linked to many cardiovascular diseases, such as myocardial infarction and heart failure, and exhibits cardioprotective effect in ischemia-reperfusion injury. The present study was designed to investigate the course of CT-1 in patients undergoing on-pump coronary artery bypass grafting (CABG), and to evaluate the relationship between plasma CT-1 levels and postoperative cardiac function.
  
  
  METHODS
  Twenty-four patients undergoing elective CABG were studied. Radial artery blood samples were collected before cardiopulmonary bypass (CPB), 5 min and 20 min after reperfusion, and 1 h, 6 h, 12 h and 24 h after CPB. Coronary sinus blood samples were collected before CPB, 5 min and 20 min after reperfusion. Plasma CT-1 levels were measured using the ELISA method. Hemodynamic data were collected.
  
  
  RESULTS
  Peripheral CT-1 levels did not change significantly postoperatively. Trans-myocardial CT-1 levels increased significantly 5 min and 20 minutes after reperfusion as compared to baseline. A weak positive correlation (r = 0.408, p = 0.048) was found between trans-myocardial CT-1 levels at 20 min after reperfusion and CI at 12 h after CPB.
  
  
  CONCLUSIONS
  The heart secretes CT-1 after ischemic injury. The precise effect of CT-1 in CABG needs further investigation.
authors.affiliation: Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, PR China.
authors.forename: Yikui
authors.initials: Y
authors.lastname: Tian
authors.forename: Xinhua
authors.initials: X
authors.lastname: Ruan
authors.forename: Jari
authors.initials: J
authors.lastname: Laurikka
authors.forename: Seppo
authors.initials: S
authors.lastname: Laine
authors.forename: Matti
authors.initials: M
authors.lastname: Tarkka
authors.forename: Minxin
authors.initials: M
authors.lastname: Wei
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D059035:Perioperative Period
chemical_list: D016207:Cytokines; C092073:cardiotrophin 1