title: Impact of cortical plasticity on information signaled by populations of neurons in the cerebral cortex.
abstract: The performance of neural codes to represent attributes of sensory signals has been evaluated in the vertebrate peripheral and central nervous system. Here, we determine how information signaled by populations of neurons is modified by plasticity. Suprathreshold neuronal responses from a large number of neurons were recorded in the juvenile mouse barrel cortex using dithered random-access scanning. Pairing of one input with another resulted in a long-lasting, input-specific modification of the cortical responses. Mutual information analysis indicated that cortical plasticity efficiently changed information signaled by populations of neurons. The contribution of neural correlations to the change in mutual information was negative. The largest factor limiting fidelity of mutual information after pairing was a low reliability of the modified cortical responses.
authors.affiliation: Center for Learning and Memory, Section of Neurobiology, The University of Texas at Austin, 1 Univ. Sta., C7000, Austin, TX 78712, USA. HKoester@mail.utexas.edu
authors.forename: Juan Diego
authors.initials: JD
authors.lastname: Pita-Almenar
authors.forename: Gayathri Nattar
authors.initials: GN
authors.lastname: Ranganathan
authors.forename: Helmut Joachim
authors.initials: HJ
authors.lastname: Koester
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009924:Organ Culture Techniques; D015398:Signal Transduction / Q000502:physiology