title: Association of serum retinol binding protein 4 with adiposity and pubertal development in Korean children and adolescents.
abstract: Retinol binding protein 4 (RBP4) has been postulated to provide a new link between obesity and insulin resistance. We aimed to assess the relationship between serum RBP4 and insulin resistance by investigating serum RBP4 levels in children and adolescents according to degree of obesity and pubertal stage. A total of 103 (30 lean, 39 overweight, 34 obese) were evaluated for serum RBP4, adiponectin, insulin, glucose and lipid profiles. RBP4 levels of obese and overweight groups were higher than those of lean group. RBP4 level was higher in pubertal group than in prepubertal group. RBP4 was positively correlated with age, height, weight, body mass index (BMI), abdominal circumference, systolic blood pressure, fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), total cholesterol and triglyceride, and inversely with adiponectin. In the multiple linear regression analysis, RBP4 was found to be independently associated with pubertal stage, BMI and triglyceride but not with HOMA-IR. In conclusion, serum RBP4 level is related with degree of adiposity and pubertal development. The association of RBP4 with insulin resistance is supposed to be secondary to the relation between RBP4 and adipose tissue in children and adolescents.
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Rhie
authors.forename: Byung-Min
authors.initials: BM
authors.lastname: Choi
authors.forename: So Hee
authors.initials: SH
authors.lastname: Eun
authors.forename: Chang Sung
authors.initials: CS
authors.lastname: Son
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Park
authors.forename: Kee-Hyoung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D052242:Adiponectin / Q000097:blood; D050154:Adiposity; D000293:Adolescent; D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology; D011627:Puberty / Q000097:blood* / Q000378:metabolism / Q000502:physiology; D056910:Republic of Korea; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D014280:Triglycerides; D002784:Cholesterol