title: Up-regulation of major vault protein in the frontal cortex of patients with intractable frontal lobe epilepsy.
abstract: Major vault protein (MVP) is a vesicular drug transporter and may participate in multidrug resistance (MDR). The aim of this study was to determine the expression and cellular localization of MVP in refractory frontal lobe epilepsy (FLE). We detected MVP expression in tissue samples from the refractory frontal cortex of 30 patients who had been surgically treated for refractory epilepsy. We compared these tissues with twelve histologically normal frontal lobe samples from controls. In the control group, the expression of MVP was faint in the cortex. The expression of MVP protein increased dramatically in the refractory epilepsy group; MVP immunoreactivity (IR) was observed in the cytoplasm of neurons. Thus, MVP protein was increased in the frontal cortex of patients with refractory epilepsy. Further research is necessary to determine whether or not MVP plays a role in the mechanisms underlying drug resistance in refractory FLE.
authors.affiliation: Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Road, Xi'an 710038, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000378:metabolism / Q000601:surgery; D017034:Epilepsy, Frontal Lobe / Q000378:metabolism* / Q000601:surgery; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D015854:Up-Regulation / Q000502:physiology*; D020394:Vault Ribonucleoprotein Particles / Q000096:biosynthesis* / Q000235:genetics; D055815:Young Adult; D000099187:Major Vault Protein
chemical_list: D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein