title: Therapeutic outcomes of papillary thyroid cancer patients in different risk groups.
abstract: OBJECTIVE
  The objective of this study was to determine the therapeutic outcome of papillary thyroid cancer (PTC) patients in different risk groups in one institute.
  
  
  METHODS
  A total of 1,759 PTC patients were categorized into low- (n = 1,123), intermediate- (n = 75), and high-risk (n = 561) groups according to tumor-node-metastasis (TNM) stage.
  
  
  RESULTS
  Of the patients, 15.1% presented with lymph node metastases, and 4.6% presented with distant metastases at the time of thyroid operation. After 8.0 ± 0.1 years of follow-up, 73 (4.2%) patients died of thyroid cancer. Tumor size, local invasion, and lymph node metastases adversely influenced recurrence and survival. Of the patients in the 3 groups, 9 (0.8%), 8 (10.7%), and 56 (10.0%) died of thyroid cancer, respectively. In addition, 88 (7.8%), 14 (18.7%), and 144 (25.8%) patients showed recurrence during the follow-up period. Patients with highly aggressive histological patterns showed increased recurrence and cancer mortality compared with the low-risk group; otherwise, values were not higher than those of the high-risk group.
  
  
  CONCLUSIONS
  The cancer-related mortality was nearly 10% in the intermediate- and high-risk groups, and the patients in these groups required aggressive surgical and postoperative adjuvant therapies.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Keelung and Linkou Chang Gung Memorial Hospital, Chang Gung University, Kweishan, Taoyuan Hsien, Taiwan, ROC.
authors.forename: Bie-Yu
authors.initials: BY
authors.lastname: Huang
authors.forename: Jen-Der
authors.initials: JD
authors.lastname: Lin
authors.forename: Tzu-Chieh
authors.initials: TC
authors.lastname: Chao
authors.forename: Kun-Ju
authors.initials: KJ
authors.lastname: Lin
authors.forename: Chuen
authors.initials: C
authors.lastname: Hseuh
authors.forename: Ngan-Ming
authors.initials: NM
authors.lastname: Tsang
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma; D002291:Carcinoma, Papillary; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D013965:Thyroidectomy; D047368:Tumor Burden
chemical_list: D007457:Iodine Radioisotopes