title: The nano spray dryer B-90.
abstract: BACKGROUND
  Spray drying is an extremely well-established technology for the production of micro-particulate powders suited for a variety of drug delivery applications. In recent years, the rise in nanomedicine has placed increased pressure on the existing systems to produce nanoparticles in good yield and with a narrow size distribution. However, the separation and collection of nanoparticles with conventional spray dryer set ups is extremely challenging due to their typical low collection efficiency for fine particles < 2 μm. Currently, nanoparticles have to be agglomerated into larger microparticles, via a two-step approach, in order to collect them in a sizeable amount. However, this method has to contend with the issue of adequate redispersibility of the primary particles to reap the full benefits of nanosizing.
  
  
  METHODS
  An overview on the advances in spray drying technology is provided in this review with particular emphasis on the novel Buchi® Nano Spray Dryer B-90. Readers will appreciate the limitations of conventional spray drying technology, understand the mechanisms of the Buchi® Nano Spray Dryer B-90, and also learn about the strengths and shortcomings of the system.
  
  
  CONCLUSIONS
  The Buchi® Nano Spray Dryer B-90 offers a new, simple and alternative approach for the production of nanoparticles suited for a variety of drug delivery applications.
authors.affiliation: Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1, Pesek Road, Jurong Island, Singapore 627833, Singapore. desmond_heng@ices.a-star.edu.sg
authors.forename: Desmond
authors.initials: D
authors.lastname: Heng
authors.forename: Sie Huey
authors.initials: SH
authors.lastname: Lee
authors.forename: Wai Kiong
authors.initials: WK
authors.lastname: Ng
authors.forename: Reginald B H
authors.initials: RB
authors.lastname: Tan
mesh_terms: D016503:Drug Delivery Systems; D036103:Nanotechnology; D012997:Solvents; D055672:Static Electricity
chemical_list: D012997:Solvents