title: [Flavonoids with special B-ring from Macrothelypteris viridifrons and their anti-proliferative effects on tumor cell].
abstract: OBJECTIVE
  To study the chemical constituents of Macrothelypteris viridifrons and their anti-proliferative effects on tumor cell.
  
  
  METHODS
  The compounds were isolated by column chromatography with silica gel, C18 reverse-phase silica gel, sephadex LH-20, and their structures were elucidated on the basis of physiochemical propertities and spectral analysis. The antitumor activities of all compounds were tested with MOLT4, Hep G2, A-549, MCF-7, HT-29, PC-3 tumor cell lines.
  
  
  RESULTS
  Five compounds were isolated and identified as protoapigenone (1), protoapigenin (2), protoapigenin-4'-O-beta-D-glucopyanoside (3), 5,7-dihydroxy-2-(1,2-isopropyldioxy-4-oxo-cyclohex-5-enyl) -chromen-4-one (4), 5,7-dihydroxy-2-(1-hydroxy-2,6-dimethoxy-cyclohex-4-oxo) -chromen-4-one (5), respectively.
  
  
  CONCLUSIONS
  All compounds were obtained from this plant for the first time. Compounds 1, 4 and 5 showed strong anti-proliferative effects on six tumor cells, which were in concentration-dependent manner.
authors.affiliation: College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan 430030, China. wah0716@yahoo.cn
authors.forename: Anhua
authors.initials: A
authors.lastname: Wei
authors.forename: Guanghua
authors.initials: G
authors.lastname: Wu
authors.forename: Chaomei
authors.initials: C
authors.lastname: Xiong
authors.forename: Daonian
authors.initials: D
authors.lastname: Zhou
authors.forename: Yaling
authors.initials: Y
authors.lastname: Cai
authors.forename: Jinlan
authors.initials: J
authors.lastname: Ruan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D029624:Ferns / Q000737:chemistry* / Q000187:drug effects*; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D019073:HT29 Cells; D056945:Hep G2 Cells; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids