title: A genome-wide association study of DSM-IV cannabis dependence.
abstract: Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, Saint Louis, MO 63110, USA. arpana@wustl.edu
authors.forename: Arpana
authors.initials: A
authors.lastname: Agrawal
authors.forename: Michael T
authors.initials: MT
authors.lastname: Lynskey
authors.forename: Anthony
authors.initials: A
authors.lastname: Hinrichs
authors.forename: Richard
authors.initials: R
authors.lastname: Grucza
authors.forename: Scott F
authors.initials: SF
authors.lastname: Saccone
authors.forename: Robert
authors.initials: R
authors.lastname: Krueger
authors.forename: Rosalind
authors.initials: R
authors.lastname: Neuman
authors.forename: William
authors.initials: W
authors.lastname: Howells
authors.forename: Sherri
authors.initials: S
authors.lastname: Fisher
authors.forename: Louis
authors.initials: L
authors.lastname: Fox
authors.forename: Robert
authors.initials: R
authors.lastname: Cloninger
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Dick
authors.forename: Kimberly F
authors.initials: KF
authors.lastname: Doheny
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: Alison M
authors.initials: AM
authors.lastname: Goate
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: Eric
authors.initials: E
authors.lastname: Johnson
authors.forename: John
authors.initials: J
authors.lastname: Kramer
authors.forename: Samuel
authors.initials: S
authors.lastname: Kuperman
authors.forename: John I
authors.initials: JI
authors.lastname: Nurnberger
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pugh
authors.forename: Marc
authors.initials: M
authors.lastname: Schuckit
authors.forename: Jay
authors.initials: J
authors.lastname: Tischfield
authors.forename: John P
authors.initials: JP
authors.lastname: Rice
authors.forename: Kathleen K
authors.initials: KK
authors.lastname: Bucholz
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Bierut
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000483:Alleles; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D002189:Marijuana Abuse / Q000175:diagnosis / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics; D028044:Phosphate-Binding Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015238:Sulfotransferases / Q000235:genetics; D055815:Young Adult
chemical_list: C118719:ANKFY1 protein, human; D008565:Membrane Proteins; D028044:Phosphate-Binding Proteins; C411659:CHST11 protein, human; D015238:Sulfotransferases