title: Cardiomyopathy of Duchenne muscular dystrophy: current understanding and future directions.
abstract: Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy and occurs in 1 in 3500 male births. Improved survival due to improvements in clinical care of the musculoskeletal and respiratory systems has led to an increased incidence of cardiomyopathy. Cardiac-related deaths are now seen in approximately 20% of DMD patients. Our current understanding of DMD cardiomyopathy has increased significantly over the past 10 years, but further research is required to improve cardiac treatment and outcomes in DMD. This review provides a summary of the current literature and discussion of potential new therapies for DMD cardiomyopathy.
authors.affiliation: Division of Cardiology, Research Center for Genetic Medicine, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA. cspurney@cnmc.org
authors.forename: Christopher F
authors.initials: CF
authors.lastname: Spurney
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D032882:Comprehension; D004562:Electrocardiography / Q000379:methods; D005544:Forecasting; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D020388:Muscular Dystrophy, Duchenne / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*