title: Lipoxin A4 and its analog suppress hepatocellular carcinoma via remodeling tumor microenvironment.
abstract: Macrophages play an important role in tumor inflammatory microenvironment, lipoxin (LX), the 'stop signal' for inflammation, has been extensively studied preclinically for its anti-inflammatory or inflammatory pro-resolving effect. Here, we showed that LXA(4) could promote the apoptosis and inhibit the proliferation, migration and angiogenesis of HepG2 hepatocarcinoma cells stimulated by lipopolysaccharide (LPS) or activated macrophage-conditioned media (ACM). Moreover, BML-111, the analog of LXA(4), effectively inhibited the proliferation, invasion and angiogenesis of tumor in H22 hepatocarcinoma cell bearing mice. These results showed that LXA(4) could be a possible candidate for liver cancer therapy, and blocking the activation of macrophages would be an effective drug target.
authors.affiliation: Department of Pathophysiology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Hao
authors.forename: Miao
authors.initials: M
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.forename: Lei
authors.initials: L
authors.lastname: Cai
authors.forename: Ke
authors.initials: K
authors.lastname: Tang
authors.forename: Pan
authors.initials: P
authors.lastname: Yi
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Duyun
authors.initials: D
authors.lastname: Ye
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D017077:Culture Media, Conditioned; D006538:Heptanoic Acids / Q000494:pharmacology; D006801:Humans; D044045:Lipoxins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008113:Liver Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: C530770:5(S),6(R)-7-trihydroxyheptanoic acid, methyl ester; D017077:Culture Media, Conditioned; D006538:Heptanoic Acids; D044045:Lipoxins; C040527:lipoxin A4