title: Cationic phenylene ethynylene polymers and oligomers exhibit efficient antiviral activity.
abstract: The antiviral activities of poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were investigated using two model viruses, the T4 and MS2 bacteriophages. Under UV/visible light irradiation, significant antiviral activity was observed for all of the CPEs and OPEs; without irradiation, most of these compounds exhibited high inactivation activity against the MS2 phage and moderate inactivation ability against the T4 phage. Transmission electron microscopy (TEM) and SDS polyacrylamide gel electrophoresis (SDS-PAGE) reveal that the CPEs and OPEs exert their antiviral activity by partial disassembly of the phage particle structure in the dark and photochemical damage of the phage capsid protein under UV/visible light irradiation.
authors.affiliation: Department of Chemical and Nuclear Engineering, Center for Biomedical Engineering, University of New Mexico, Albuquerque, New Mexico 87131-1341, United States.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Taylor D
authors.initials: TD
authors.lastname: Canady
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhou
authors.forename: Yanli
authors.initials: Y
authors.lastname: Tang
authors.forename: Dominique N
authors.initials: DN
authors.lastname: Price
authors.forename: David G
authors.initials: DG
authors.lastname: Bear
authors.forename: Eva Y
authors.initials: EY
authors.lastname: Chi
authors.forename: Kirk S
authors.initials: KS
authors.lastname: Schanze
authors.forename: David G
authors.initials: DG
authors.lastname: Whitten
mesh_terms: D000480:Alkynes / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D017122:Bacteriophage T4 / Q000187:drug effects* / Q000472:pathogenicity / Q000648:ultrastructure; D002412:Cations; D003588:Cytopathogenic Effect, Viral; D004987:Ethers / Q000737:chemistry / Q000494:pharmacology*; D017909:Levivirus / Q000187:drug effects* / Q000472:pathogenicity / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D000480:Alkynes; D000998:Antiviral Agents; D002412:Cations; D004987:Ethers; D011108:Polymers; C436384:phenyleneethynylene