title: Impact of physical activity and doping on epigenetic gene regulation.
abstract: To achieve success in sports, many athletes consume doping substances, such as anabolic androgenic steroids and growth hormones, and ignore the negative influence of these drugs on their health. Apart from the unethical aspect of doping in sports, it is essential to consider the tremendous risk it represents to their physical condition. The abuse of pharmaceuticals which improve athletic performance may alter the expression of specific genes involved in muscle and bone metabolism by epigenetic mechanisms, such as DNA methylation and histone modifications. Moreover, excessive and relentless training to increase the muscle mass, may also have an influence on the health of the athletes. This stress releases neurotransmitters and growth factors, and may affect the expression of endogenous genes by DNA methylation, too. This paper focuses on the relationship between epigenetic mechanisms and sports, highlights the potential consequences of abuse of doping drugs on gene expression, and describes methods to molecularly detect epigenetic changes of gene markers reflecting the physiological or metabolic effects of doping agents.
authors.affiliation: Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Germany. hschwarz@uke.uni-hamburg.de.
authors.forename: Heidi
authors.initials: H
authors.lastname: Schwarzenbach
mesh_terms: D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D019175:DNA Methylation / Q000187:drug effects; D004300:Doping in Sports; D044127:Epigenesis, Genetic / Q000187:drug effects*; D013006:Growth Hormone / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology; D006657:Histones / Q000235:genetics; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*
chemical_list: D045930:Anabolic Agents; D006133:Growth Substances; D006657:Histones; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone