title: E- and P-selectin: differences, similarities and implications for the design of P-selectin antagonists.
abstract: Selectins form a family of Ca2+ -dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising therapeutic approach to treat acute and chronic inflammatory diseases which are caused by excessive extravasation of leukocytes. This mini-review highlights the major structural differences between E- and P-selectin and summarizes the resulting strategies for the design of selectin antagonists.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Basel, Klingelbergstrasse 50 CH-4056 Basel. florian.binder@unibas.ch
authors.forename: Florian P C
authors.initials: FP
authors.lastname: Binder
authors.forename: Beat
authors.initials: B
authors.lastname: Ernst
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D015195:Drug Design; D019040:E-Selectin / Q000737:chemistry* / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D009844:Oligosaccharides / Q000737:chemistry* / Q000378:metabolism; D019007:P-Selectin / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D000080506:Sialyl Lewis X Antigen
chemical_list: D000893:Anti-Inflammatory Agents; D019040:E-Selectin; D008562:Membrane Glycoproteins; D009844:Oligosaccharides; D019007:P-Selectin; C084882:P-selectin ligand protein; D000080506:Sialyl Lewis X Antigen