title: MMP-2 expression in 102 patients with glottic laryngeal cancer.
abstract: In order to evaluate the potential of matrix metalloproteinase 2 (MMP-2) as a prognostic factor for glottic laryngeal cancer. One hundred and two surgical specimens from patients with glottic laryngeal cancer who underwent laryngectomy for their disease in the University Hospital of Patras, Greece from 1998 to 2005 were reviewed retrospectively regarding MMP-2 expression via immunohistochemistry. Immunostaining was performed using a streptavidin-biotin peroxidase complex technique (LSAB). Results revealed that 54 of 102 patients (52.9%) had positive cytoplasmic staining for MMP-2. Kaplan-Meier analysis demonstrated statistically significant difference (p = 0.037) for the 5-year overall survival rate between the groups with positive and negative MMP-2 expression, and marginal statistical significance for the disease free survival rate (p = 0.048). The capsule rupture of metastatic lymph nodes and MMP-2 expression in primary tumor site also seems to be related (p = 0.047). Statistical significance could not be established between MMP-2 expression and the clinicopathological features of the disease (T stage, N stage, clinical stage, differentiation). In conclusion, MMP-2 expression was related with worse overall and disease-free survival and could be considered as a potential marker of poor prognosis.
authors.affiliation: Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital of Patras, 26500, Rion Patras, Greece. 6976154469@mycosmos.gr
authors.forename: Antony
authors.initials: A
authors.lastname: Mallis
authors.forename: Afshin
authors.initials: A
authors.lastname: Teymoortash
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Mastronikolis
authors.forename: Jochen A
authors.initials: JA
authors.lastname: Werner
authors.forename: Theodoros A
authors.initials: TA
authors.lastname: Papadas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy; D007830:Larynx / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000032:analysis*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2