title: Synthesis of 8-arylquinolines via one-pot Pd-catalyzed borylation of quinoline-8-yl halides and subsequent Suzuki-Miyaura coupling.
abstract: A one-pot process has been developed for the synthesis of 8-arylquinolines via Pd-catalyzed borylation of quinoline-8-yl halides and subsequent Suzuki-Miyaura coupling with aryl halides using n-BuPAd(2) as ligand. Yields of up to 98% were obtained.
authors.affiliation: Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA. yongda.zhang@boehringer-ingelheim.com
authors.forename: Yongda
authors.initials: Y
authors.lastname: Zhang
authors.forename: Joe
authors.initials: J
authors.lastname: Gao
authors.forename: Wenjie
authors.initials: W
authors.lastname: Li
authors.forename: Heewon
authors.initials: H
authors.lastname: Lee
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Lu
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006846:Hydrocarbons, Halogenated; D008024:Ligands; D011804:Quinolines; D010165:Palladium