title: Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells.
abstract: Cancers of the breast and other tissues arise from aberrant decision-making by cells regarding their survival or death, proliferation or quiescence, damage repair or bypass. These decisions are made by molecular signalling networks that process information from outside and from within the breast cancer cell and initiate responses that determine the cell's survival and reproduction. Because the molecular logic of these circuits is difficult to comprehend by intuitive reasoning alone, we present some preliminary mathematical models of the basic decision circuits in breast cancer cells that may aid our understanding of their susceptibility or resistance to endocrine therapy.
authors.affiliation: Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA. tyson@vt.edu
authors.forename: John J
authors.initials: JJ
authors.lastname: Tyson
authors.forename: William T
authors.initials: WT
authors.lastname: Baumann
authors.forename: Chun
authors.initials: C
authors.lastname: Chen
authors.forename: Anael
authors.initials: A
authors.lastname: Verdugo
authors.forename: Iman
authors.initials: I
authors.lastname: Tavassoly
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Louis M
authors.initials: LM
authors.lastname: Weiner
authors.forename: Robert
authors.initials: R
authors.lastname: Clarke
mesh_terms: D017209:Apoptosis; D001343:Autophagy; D001943:Breast Neoplasms / Q000473:pathology*; D002453:Cell Cycle; D019070:Cell Lineage; D056741:Cyclin D / Q000502:physiology; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006801:Humans; D008962:Models, Theoretical; D011960:Receptors, Estrogen / Q000502:physiology; D015398:Signal Transduction
chemical_list: D056741:Cyclin D; D004967:Estrogens; D011960:Receptors, Estrogen