title: A survey of spontaneous occurrence of ochratoxin A residues in chicken tissues and concurrence with histopathological changes in liver and kidneys.
abstract: Toxicological and histopathological investigations of tissues of commercially slaughtered chickens were carried out to provide a preliminary evaluation of the incidence of occurrence of ochratoxin A (OTA) in chicken sold in Serbian retail market. In addition, the etiology of nephropathies of these chickens was elucidated. The majority of these tissue samples were not found to contain measurable amounts of OTA. Moreover, the OTA levels found in analyzed tissues were generally low and there was no positive correlation between the presence of OTA and the frequency of histopathological changes. Histopathological changes such as degenerative changes in the kidneys and liver differed from the classical description of the mycotoxic nephropathy, indicating that the chicken nephropathy observed in Serbia may have a multitoxic etiology with possible synergistic effect between microorganisms and natural toxins, usually present in low concentrations. The low OTA results also suggested that chicken meat available in the retail market in Serbia are unlikely to pose any significant adverse health risk to the consumers with respect to OTA toxicity.
authors.affiliation: Institute of Meat Hygiene and Technology, Belgrade, Serbia. dragan@inmesbgd.com
authors.forename: Dragan
authors.initials: D
authors.lastname: Milićević
authors.forename: Milijan
authors.initials: M
authors.lastname: Jovanović
authors.forename: Vesna
authors.initials: V
authors.lastname: Matekalo-Sverak
authors.forename: Tatjana
authors.initials: T
authors.lastname: Radicević
authors.forename: Milan M
authors.initials: MM
authors.lastname: Petrović
authors.forename: Slobodan
authors.initials: S
authors.lastname: Lilić
mesh_terms: D000821:Animal Feed; D000818:Animals; D002645:Chickens; D005506:Food Contamination; D007668:Kidney / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D009793:Ochratoxins / Q000032:analysis / Q000633:toxicity*; D009929:Organ Size
chemical_list: D009793:Ochratoxins; C025589:ochratoxin A