title: A practical strategy for constructing nanodrugs using carbon nanotubes as carriers.
abstract: Carbon nanotubes, acting as nanocarriers, can be combined with drug molecules through various chemical or physical routes in which hydrophilic modifications of the nanotubes are required. Such types of hydrophilic modifications typically involve addition reactions at the nanotube sidewalls, the reactions of nanotube-bound carboxylic groups, and/or coating of the nanotubes with amphiphilic molecules. In this chapter, we introduce detailed approaches for covalently linking drug compounds to multiwalled carbon nanotubes, as well as labeling the synthesized drug-bearing carbon nanotube conjugates with fluorescent or radioactive molecules.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Xiqun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000577:Amides / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D000818:Animals; D002166:Camptothecin / Q000031:analogs & derivatives / Q000737:chemistry; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D019855:Ethylene Glycol / Q000737:chemistry; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D051379:Mice; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D051381:Rats; D019802:Succinic Acid / Q000737:chemistry; D016284:Technetium Tc 99m Pentetate / Q000737:chemistry; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000577:Amides; D000588:Amines; D004337:Drug Carriers; D005456:Fluorescent Dyes; D037742:Nanotubes, Carbon; C028098:10-hydroxycamptothecin; D019802:Succinic Acid; D019855:Ethylene Glycol; D016650:Fluorescein-5-isothiocyanate; D016284:Technetium Tc 99m Pentetate; D002166:Camptothecin