title: Application of Cox model in coagulation function in patients with primary liver cancer.
abstract: OBJECTIVE
  To analyze the distribution of coagulation parameters in patients with primary liver cancer; explore the relationship between clinical staging, survival, and coagulation parameters by using Coxproportional hazard model; and provide a parameter for clinical management and prognosis.
  
  
  METHODS
  Coagulation parameters were evaluated in 228 patients with primary liver cancer, 52 patients with common liver disease, and 52 normal healthy controls. The relationship between primary livercancer staging and coagulation parameters wasanalyzed. Follow-up examinations were performed. The Cox proportional hazard model was used to analyze the relationship between coagulationparameters and survival.
  
  
  RESULTS
  The changes in the coagulation parameters in patients with primary liver cancer were significantly different from those in normal controls. The effect of the disease on coagulation function became more obvious as the severity of liver cancer increased (p<0.05). The levels of D-dimer, fibrinogen degradation products (FDP), fibrinogen (FIB), and platelets (PLT) were negatively correlated with the long-term survival of patients with advanced liver cancer.
  
  
  CONCLUSIONS
  The stages of primary liver cancer are associated with coagulation parameters. Coagulation parameters are related to survival and risk factors. Monitoring of coagulation parameters may help ensure better surveillance and treatment for liver cancer patients.
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Guo
authors.forename: Mingwei
authors.initials: M
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.forename: Shan
authors.initials: S
authors.lastname: Zhao
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Wang
authors.forename: Qinjiong
authors.initials: Q
authors.lastname: Kang
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D013927:Thrombosis / Q000209:etiology