title: Microwave assisted synthesis of some new fused 1,2,4-triazines bearing thiophene moieties with expected pharmacological activity.
abstract: Rapid and efficient solvent-free synthesis of 4-amino-3-mercapto-6-[2-(2-thienyl)vinyl]-1,2,4-triazin-5(4H)-one 1 under microwave irradiation is described. Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-b][1,3,4]thiadiazinones, 1,3,4-thiadiazolo[2,3-c][1,2,4]triazinone and pyrazolo[5,1-c]-[1,2,4]triazine-7-carbonitrile, have been synthesized by treatment of 1 with bifunctional oxygen and halogen compounds, CS₂/KOH and malononitrile via heterocyclization reactions, in addition to some uncondensed triazines. Structures of the products have been deduced from their elemental analysis and spectral data (IR, ¹H-NMR, ¹³C-NMR). Select new synthesized compounds were screened as anticancer agents, with some showing activity as cytotoxic agents against different cancer cell lines.
authors.affiliation: Department of Chemistry, Faculty of Science, Taif University, Taif 21974, Kingdom of Saudi Arabia. h_saadzag@yahoo.com
authors.forename: Hosam A
authors.initials: HA
authors.lastname: Saad
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Youssef
authors.forename: Mosselhi A
authors.initials: MA
authors.lastname: Mosselhi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D008872:Microwaves; D055668:Photochemical Processes; D013876:Thiophenes / Q000737:chemistry*; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013876:Thiophenes; D014227:Triazines