title: Validation of the ABCD²-I score to predict stroke risk after transient ischemic attack.
abstract: OBJECTIVE
  The primary aim of this study was to prospectively validate the predictive value of the ABCD²-I score and to then compare the predictive accuracy of the ABCD² score and ABCD²-I score for 1-year risk of stroke in admitted patients with transient ischemic attack (TIA) as defined by the World Health Organization (WHO) time-based criteria.
  
  
  METHODS
  Data were collected from patients with transient ischemic attack within 7 days of symptom onset, and all patients underwent diffusion-weighted imaging (DWI). The predictive values of stratified 1-year rates of recurrent stroke were compared using the age, blood pressure, clinical signs, symptom duration, and ABCD² score with defined cutoff values (0-3, low-risk, 4-5, medium-risk, 6-7, high-risk) and ABCD²-I score cutoff values (0-3, low-risk, 4-6, medium-risk, 7-10, high-risk). In addition, to evaluate the performance of the two scores, we calculated the area under the curve by receiver-operating characteristic.
  
  
  RESULTS
  Four hundred and ten patients with completed DWI and 12-month follow-up with initial TIA were enrolled in this study. Of these, 111 (27.07%) patients had annual stroke risk. The risk of stroke increased with increasing ABCD² score and ABCD²-I score. The ABCD²-I score had the higher predictive value with areas under the curve of 0.77 than the ABCD² score with areas under the curve of 0.59.
  
  
  CONCLUSIONS
  The ABCD²-I score is a useful tool for stratifying the 1-year risk of stroke in TIA patients, and it improves the discriminatory power of the ABCD² score for the prediction of stroke risk.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Meng
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Pu
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.forename: Chunxue
authors.initials: C
authors.lastname: Wang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002536:Cerebral Arteries / Q000473:pathology*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D020521:Stroke / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult