title: Triterpenoids with neurotrophic activity from Ganoderma lucidum.
abstract: A new triterpenoid, 4,4,14α-trimethyl-5α-chol-7,9(11)-dien-3-oxo-24-oic acid (1), together with seven known triterpenoids, were isolated from the dried fruiting bodies of Ganoderma lucidum. Their structures were elucidated by extensive spectroscopic analyses. Bioassay results revealed that compounds 1 and methyl ganoderic acid B (5) had nerve growth factor-like neuronal survival-promoting effects, whereas compounds 1, and 4-7 showed brain-derived neurotrophic factor-like neuronal survival-promoting activities.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Fanny C F
authors.initials: FC
authors.lastname: Ip
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
authors.forename: Nancy Y
authors.initials: NY
authors.lastname: Ip
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000818:Animals; D001681:Biological Assay; D002470:Cell Survival / Q000187:drug effects; D002681:China; D005638:Fruit / Q000737:chemistry*; D007810:Lanosterol / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D009414:Nerve Growth Factors / Q000737:chemistry / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D011134:Polysaccharides / Q000494:pharmacology; D020940:Reishi / Q000737:chemistry*; D013057:Spectrum Analysis; D013261:Sterols / Q000494:pharmacology; D014315:Triterpenes / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D009414:Nerve Growth Factors; D011134:Polysaccharides; D013261:Sterols; D014315:Triterpenes; D007810:Lanosterol; C476673:ganoderic acid B