title: Optical polarimetry for noninvasive glucose sensing enabled by Sagnac interferometry.
abstract: Optical polarimetry is used in pharmaceutical drug testing and quality control for saccharide-containing products (juice, honey). More recently, it has been proposed as a method for noninvasive glucose sensing for diabetic patients. Sagnac interferometry is commonly used in optical gyroscopes, measuring minute Doppler shifts resulting from mechanical rotation. In this work, we demonstrate that Sagnac interferometers are also sensitive to optical rotation, or the rotation of linearly polarized light, and are therefore useful in optical polarimetry. Results from simulation and experiment show that Sagnac interferometers are advantageous in optical polarimetry as they are insensitive to net linear birefringence and alignment of polarization components.
authors.affiliation: College of Optical Sciences, The University of Arizona, 1630 E. University Boulevard, Tucson, Arizona 85721, USA. winkleramy@gmail.com
authors.forename: Amy M
authors.initials: AM
authors.lastname: Winkler
authors.forename: Garret T
authors.initials: GT
authors.lastname: Bonnema
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Barton
mesh_terms: D000465:Algorithms; D001082:Aqueous Humor / Q000378:metabolism; D001718:Birefringence; D003198:Computer Simulation; D003315:Cornea / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism; D005947:Glucose / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007368:Interferometry / Q000295:instrumentation*; D008954:Models, Biological; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods; D009904:Optical Rotation; D055095:Optics and Photonics / Q000295:instrumentation; D012029:Refraction, Ocular; D013057:Spectrum Analysis; D014785:Vision, Ocular
chemical_list: D005947:Glucose