title: Regulation of immune responses, apoptosis, and tumorigenesis by separate FOXP-3-dependent genes: connection with clinical manifestations.
abstract: Recently, forkhead/winged-helix family box protein P3 (FOXP-3) was described as the main regulator of regulatory T cells' activity. This transcription factor has the ability to control the immunosuppressive response of regulatory T cells. FOXP-3 has binding sites for different genes specific for proteins with various important functions. In this article, selected FOXP-3-dependent genes with known functions were divided into two groups. The first group of genes has main immunoregulatory functions, and the second group has the ability to regulate apoptosis and tumorigenesis. Investigation of the functions of all FOXP-3-dependent genes opens perspectives for applications in different fields of basic and clinical research.
authors.affiliation: Department of Pediatrics and Center for Applied Genomics, 1(st) School of Medicine, Charles University, Prague, Czech Republic.
authors.forename: Oxana V
authors.initials: OV
authors.lastname: Klimenko
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D051858:Forkhead Transcription Factors / Q000235:genetics*; D006801:Humans; D051379:Mice; D015398:Signal Transduction; D013577:Syndrome; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors