title: [Distal coronary thrombosis during L-asparaginase treatment for an acute lymphoblastic leukaemia].
abstract: A 53-year-old man is treated by L-asparaginase for an acute lymphoblastic leukaemia. He received anti thrombin infusions. A systematic electrocardiogram showed an asymptomatic subepicardium ischemia without troponin elevation. Echocardiography and heart magnetic resonance imaging showed an apical thrombus facing a zone of myocardial necrosis. A thrombus regression was observed under anticoagulation. Atypical and asymptomatic coronary thrombosis may occur following L-asparaginase treatment. Regular electrocardiogram monitoring is proposed along this treatment. Arterial thrombosis associated with anti tumor chemotherapies are reviewed.
authors.affiliation: Service d'hématologie, CH Béziers, 2, rue Valentin-Haüy, 34525 Béziers cedex, France.
authors.forename: J-B
authors.initials: JB
authors.lastname: Fraison
authors.forename: P
authors.initials: P
authors.lastname: Calvet
authors.forename: I
authors.initials: I
authors.lastname: Domnisoru
authors.forename: S
authors.initials: S
authors.lastname: Altamiranda
authors.forename: H
authors.initials: H
authors.lastname: Vernhet-Kovacsik
authors.forename: A
authors.initials: A
authors.lastname: Saad
authors.forename: P
authors.initials: P
authors.lastname: Gallay
authors.forename: J-L
authors.initials: JL
authors.lastname: Reny
authors.forename: P
authors.initials: P
authors.lastname: Berdague
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects*; D003328:Coronary Thrombosis / Q000139:chemically induced* / Q000188:drug therapy; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D001215:Asparaginase