title: Site-selective labeling at Cys302 of aldehyde dehydrogenase unveils a selective mitochondrial stain.
abstract: A mitochondria-trackable fluorophore, CDy2, selectively labels Cys302 in the active site of mitochondrial aldehyde dehydrogenase (ALDH2).
authors.affiliation: Korea Institute of Science and Technology (KIST), Brain Science Institute, Center for Neuro-medicine, Seoul, South Korea.
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Jin Kak
authors.initials: JK
authors.lastname: Lee
authors.forename: Jun-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Chang No
authors.initials: CN
authors.lastname: Yoon
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D000345:Affinity Labels / Q000737:chemistry / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism; D057809:HEK293 Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D016297:Mutagenesis, Site-Directed; D010880:Piperidines / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000345:Affinity Labels; C558715:CDy2 compound; D005456:Fluorescent Dyes; D006575:Heterocyclic Compounds, 3-Ring; D010880:Piperidines; D000444:Aldehyde Dehydrogenase; D003545:Cysteine