title: [Determination of avermectin, diclazuril, toltrazuril and metabolite residues in pork by high performance liquid chromatography-tandem mass spectrometry].
abstract: A method for the determination of avermectin, ivermectin, doramectin, moxidectin, eprinomectin, diclazuril, toltrazuril and its two metabolite residues in pork was developed using QuEChERS method with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The sample was extracted with acetonitrile and purified through QuEChERS method using ODS as the sorbent. The target compounds were separated on a Venusil ASB C18 column (150 mm x 2.1 mm, 3.0 microm) and detected by HPLC-MS/MS. The linear ranges were 0.005 - 0.2 mg/L and the correlation coefficients were all above 0.990. The average recoveries and the relative standard deviations ranged from 73.2% to 91.5% and from 12% to 17% at the spiked levels of 0.005, 0.01 and 0.02 mg/kg for the 9 analytes in pork matrix. This method is reliable, and suitable for the determination of the residues of avermectin and related compounds in pork.
authors.affiliation: Weifang Entry-Exit Inspection and Quarantine Bureau, Weifang 261041, China. gongxiaoming@yahoo.com
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Gong
authors.forename: Jun
authors.initials: J
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Jinling
authors.initials: J
authors.lastname: Yu
authors.forename: Hongtao
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004350:Drug Residues / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000032:analysis; D008460:Meat / Q000032:analysis*; D009570:Nitriles / Q000032:analysis*; D013552:Swine; D053719:Tandem Mass Spectrometry / Q000379:methods; D014227:Triazines / Q000032:analysis*
chemical_list: D009570:Nitriles; D014227:Triazines; D007559:Ivermectin; C019264:avermectin; C057884:diclazuril; C036670:toltrazuril