title: G-protein-coupled receptors in control of natural killer cell migration.
abstract: Natural killer (NK) cells are highly motile cells that patrol lymphoid and non-lymphoid organs, and are poised to react to infectious or other inflammatory situations. Several NK cell subsets equipped with different sets of chemotactic G-protein-coupled receptors, and which display distinct distribution across lymphoid and non-lymphoid organs, have been described. These receptors detect various guidance cues including sphingosine-1-phosphate and chemokines that orchestrate NK cell trafficking. Here, we highlight recent advances regarding the receptors involved in NK cell migration, with a focus on bone marrow egress, entry into activated lymph nodes, extravasation into inflamed tissues, and motility within lymph nodes or tumors. Understanding NK cell migration could provide a rational basis for the design of novel therapies in various clinical conditions.
authors.affiliation: Université de Lyon, France. thierry.walzer@inserm.fr
authors.forename: Thierry
authors.initials: T
authors.lastname: Walzer
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000276:immunology / Q000378:metabolism; D002450:Cell Communication / Q000276:immunology; D002465:Cell Movement / Q000276:immunology*; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D008246:Lysophospholipids / Q000276:immunology / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D019707:Receptors, Chemokine / Q000276:immunology / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000276:immunology / Q000378:metabolism
chemical_list: D018925:Chemokines; D008246:Lysophospholipids; D019707:Receptors, Chemokine; D043562:Receptors, G-Protein-Coupled; C060506:sphingosine 1-phosphate; D013110:Sphingosine