title: Predicting motor outcome and death in term hypoxic-ischemic encephalopathy.
abstract: OBJECTIVE
  Central gray matter damage, the hallmark of term acute perinatal hypoxia-ischemia, frequently leads to severe cerebral palsy and sometimes death. The precision with which these outcomes can be determined from neonatal imaging has not been fully explored. We evaluated the accuracy of early brain MRI for predicting death, the presence and severity of motor impairment, and ability to walk at 2 years in term infants with hypoxic-ischemic encephalopathy (HIE) and basal ganglia-thalamic (BGT) lesions.
  
  
  METHODS
  From 1993 to 2007, 175 term infants with evidence of perinatal asphyxia, HIE, and BGT injury seen on early MRI scans were studied. BGT, white matter, posterior limb of the internal capsule (PLIC), and cortex and brainstem abnormality were classified by severity. Motor impairment was staged using the Gross Motor Function Classification System.
  
  
  RESULTS
  The severity of BGT lesions was strongly associated with the severity of motor impairment (Spearman rank correlation 0.77; p < 0.001). The association between white matter, cortical, and brainstem injury and motor impairment was less strong and only BGT injury correlated significantly in a logistic regression model. The predictive accuracy of severe BGT lesions for severe motor impairment was 0.89 (95% confidence interval 0.83-0.96). Abnormal PLIC signal intensity predicted the inability to walk independently by 2 years (sensitivity 0.92, specificity 0.77, positive predictive value 0.88, negative predictive value 0.85). Brainstem injury was the only factor with an independent association with death.
  
  
  CONCLUSIONS
  We have shown that in term newborns with HIE and BGT injury, early MRI can be used to predict death and specific motor outcomes.
authors.affiliation: Department of Pediatrics, Hammersmith Hospital, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Martinez-Biarge
authors.forename: J
authors.initials: J
authors.lastname: Diez-Sebastian
authors.forename: O
authors.initials: O
authors.lastname: Kapellou
authors.forename: D
authors.initials: D
authors.lastname: Gindner
authors.forename: J M
authors.initials: JM
authors.lastname: Allsop
authors.forename: M A
authors.initials: MA
authors.lastname: Rutherford
authors.forename: F M
authors.initials: FM
authors.lastname: Cowan
mesh_terms: D001479:Basal Ganglia / Q000473:pathology; D002658:Developmental Disabilities / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000401:mortality* / Q000473:pathology* / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D020772:Internal Capsule / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D009069:Movement Disorders / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013788:Thalamus / Q000473:pathology; D016138:Walking