title: [Relationship between plasma levels of vasoactive intestinal peptide and feeding intolerance in preterm infants].
abstract: OBJECTIVE
  To study the changes of plasma vasoactive intestinal peptide (VIP) levels and the relationship of plasma VIP levels with feeding intolerance (FI) in preterm infants.
  
  
  METHODS
  Plasma VIP concentrations were measured using radioimmunoassay in 53 preterm infants with FI 1, 4, 7 and 14 days after birth. Fifty-nine preterm infants without FI served as the control group.
  
  
  RESULTS
  The fasting plasma concentrations of VIP in the FI group 1, 4 and 7 days after birth (129 ± 46, 144 ± 32 and 166 ± 31 pg/mL respectively) were significantly lower than those in the control group (195 ± 63, 197 ± 31 and 205 ± 34 pg/mL respectively) (P<0.05). The increased plasma VIP concentrations were associated with the increased gestational age, age in days and enteral feeding volume in the FI group. By 14 days, the plasma concentrations of VIP in the FI group (198 ± 41 pg/mL) were similar to those in the control group (202 ± 48 pg/mL) (P>0.05). The younger the infant's gestational age, the more prolonged the FI. Plasma levels of VIP on day 1 of life in the FI group were negatively correlated with the duration of FI (r=-0.799, P<0.05).
  
  
  CONCLUSIONS
  Plasma levels of VIP might be related to the development of FI in preterm infants and might serve as a predictor of FI.
authors.affiliation: Department of Neonatology, First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Run-Zhong
authors.initials: RZ
authors.lastname: Huang
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Huang
authors.forename: Guo-Sheng
authors.initials: GS
authors.lastname: Liu
mesh_terms: D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007235:Infant, Premature, Diseases / Q000097:blood*; D008297:Male; D014660:Vasoactive Intestinal Peptide / Q000097:blood*
chemical_list: D014660:Vasoactive Intestinal Peptide