title: Synthesis of 3-(aminomethylene)-2-oxoindolines by palladium-catalyzed annulation of 3-chloro-2-iodo-N-arylacrylamides with amides or amines.
abstract: A new palladium-catalyzed C-H bond activation-annulation-amination tandem method was presented for selectively synthesizing 3-(aminomethylene)-2-oxoindolines. In the presence of Pd(dba)(2), xantphos (L8), AgOAc and Na(2)CO(3), a variety of 3-chloro-2-iodo-N-arylacrylamides underwent the reaction with amides or amines to afford the corresponding 3-(aminomethylene)-2-oxoindolines in moderate to good yields.
authors.affiliation: Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University, Changsha 410081, China.
authors.forename: Guo-Bo
authors.initials: GB
authors.lastname: Deng
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Song
authors.forename: Ming-Bo
authors.initials: MB
authors.lastname: Zhou
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Wei
authors.forename: Peng
authors.initials: P
authors.lastname: Xie
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D007211:Indoles; D020106:Acrylamide; D010165:Palladium; C057812:indoline