title: Inhibition of gap junction channel attenuates the migration of breast cancer cells.
abstract: Gap junction provides intercellular communications that play a critical role in invasion of metastatic cancer cells. However, the effects of inhibiting this pathway in breast cancer cell migration have not been investigated. Here, we present data demonstrating that functional blockade of gap junctions during the formation of monolayer decreased the levels of aligned fibers of actin between neighboring breast cancer cells. Furthermore, gap junction inhibitors attenuated the invasion ability of highly metastatic MDA-MB-231 cells, but had no significant effects on less invasive MCF-7 cells, which caused by shRANKL. Our work is the first to demonstrate the inhibitory effect of gap junction channel inhibitors on the migration of highly invasive breast cancer cells.
authors.affiliation: Zhejiang Province Hospital of the Integration of Traditional Chinese and Western Medicine, Hangzhou 310003, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
authors.forename: Weili
authors.initials: W
authors.lastname: Wang
authors.forename: Caihong
authors.initials: C
authors.lastname: Guan
authors.forename: Jie
authors.initials: J
authors.lastname: Cai
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D008841:Actin Cytoskeleton / Q000187:drug effects; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000503:physiopathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects* / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D017629:Gap Junctions / Q000187:drug effects*; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D007211:Indoles; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D000442:Octanols / Q000494:pharmacology
chemical_list: D007211:Indoles; D000442:Octanols; C119129:18alpha-glycyrrhetinic acid; C007293:DAPI; D006034:Glycyrrhetinic Acid