title: In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii.
abstract: At present, colistin is among the few antibiotics effective against Acinetobacter baumannii clinical isolates. However, in the last few years, colistin-resistant A. baumannii strains have been isolated. Therefore, antibiotics effective against these usually pan-resistant colistin-resistant A. baumannii strains are required. The main objective of this study was to analyse the activity of 15 peptides against colistin-susceptible and colistin-resistant A. baumannii. The MICs were determined by microdilution. Among these 15 antimicrobial peptides (AMPs), melittin, indolicidin and mastoparan showed good activity against both colistin-susceptible and colistin-resistant A. baumannii. Further studies of mastoparan with time-killing curves showed bactericidal activity at MIC ×8 for both colistin-susceptible and colistin-resistant A. baumannii. In conclusion, mastoparan may be a potential alternative for the treatment of colistin-resistant A. baumannii infections.
authors.affiliation: Department of Clinical Microbiology, Hospital Clinic, School of Medicine, University of Barcelona, CRESIB/IDIBAPS, Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Vila-Farres
authors.forename: C
authors.initials: C
authors.lastname: Garcia de la Maria
authors.forename: R
authors.initials: R
authors.lastname: López-Rojas
authors.forename: J
authors.initials: J
authors.lastname: Pachón
authors.forename: E
authors.initials: E
authors.lastname: Giralt
authors.forename: J
authors.initials: J
authors.lastname: Vila
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology; D003091:Colistin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D020128:Inhibitory Concentration 50; D036341:Intercellular Signaling Peptides and Proteins; D008555:Melitten / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010455:Peptides / Q000494:pharmacology; D013997:Time Factors; D014862:Wasp Venoms / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D014862:Wasp Venoms; C073143:indolicidin; D008555:Melitten; C037500:mastoparan; D003091:Colistin