title: Pathological gambling in Parkinson's disease--a review of the literature.
abstract: The prevalence of pathological gambling is 3.4% to 6% in treated Parkinson's disease, which is higher than the background population rate. In this review we discuss current evidence to indicate that dopamine agonists are much more likely to trigger this behavior than either L-dopa or selective monoamine oxidase B inhibitor monotherapy. New insights from recent behavioral and functional imaging studies and possible treatment approaches are also covered. A PubMed literature search using the terms "gambling" and "Parkinson's disease," "impulse control disorder," "impulsive compulsive behaviour," "dopamine agonist," of individual dopamine agonists, and of ongoing drug trials, using http://www.clinicaltrials.gov, was carried out for the period up to January 2011.
authors.affiliation: Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, United Kingdom.
authors.forename: Atbin
authors.initials: A
authors.lastname: Djamshidian
authors.forename: Francisco
authors.initials: F
authors.lastname: Cardoso
authors.forename: Donald
authors.initials: D
authors.lastname: Grosset
authors.forename: Henrietta
authors.initials: H
authors.lastname: Bowden-Jones
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lees
mesh_terms: D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology; D018491:Dopamine Agonists / Q000009:adverse effects*; D005715:Gambling / Q000139:chemically induced* / Q000150:complications / Q000453:epidemiology / Q000266:history; D049672:History, 19th Century; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*; D039781:PubMed / Q000706:statistics & numerical data; D011877:Radionuclide Imaging; D012307:Risk Factors
chemical_list: D018491:Dopamine Agonists