title: Correlation of LAPTM4B polymorphisms with cervical carcinoma.
abstract: BACKGROUND
  Lysosome-associated protein transmembrane 4 beta (LAPTM4B), a novel oncoprotein, is overexpressed in several carcinomas. Previous studies revealed that LAPTM4B polymorphisms contribute to the risk of certain types of cancers. The purpose of this study was to investigate the association between different LAPTM4B alleles and the risk of cervical carcinoma.
  
  
  METHODS
  A case-control analysis was performed in 317 patients with cervical cancer and 416 control subjects. Genomic DNA was extracted from peripheral blood lymphocytes in all participants. LAPTM4B genotypes were determined using polymerase chain reaction. Odds ratios and 95% confidence intervals (CIs) were computed using an unconditional logistic regression model.
  
  
  RESULTS
  There was a significant difference (P<.001) in LAPTM4B*2 allele frequency between cervical cancer cases (35.8%) and controls (26.3%). There was also a significant difference in the overall genotypic distribution between patients and controls (P < .001). Using the LAPTM4B*1/1 genotype as a reference, we found that LAPTM4B allelic variation was associated with a significantly increased risk of cervical cancer, with adjusted odds ratios of 1.60 (95% CI, 1.15-2.22) and 2.12 (95% CI, 1.20-3.76) for the *1/2 and *2/2 genotype, respectively. Stratification analysis indicated that the association was more pronounced in younger subjects, smokers, premenopausal women, and women with more parities. Moreover, multiplicative joint effects were found between the *1/2 or *2/2 genotype and smoking.
  
  
  CONCLUSIONS
  The findings of this study indicated that the LAPTM4B*2 allele might be a cervical cancer risk factor and may play an important role in genetic susceptibility to cervical cancer in the Chinese population.
authors.affiliation: Department of Gynecology, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
authors.forename: Fanling
authors.initials: F
authors.lastname: Meng
authors.forename: Hongtao
authors.initials: H
authors.lastname: Song
authors.forename: Chang
authors.initials: C
authors.lastname: Luo
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Yin
authors.forename: Ye
authors.initials: Y
authors.lastname: Xu
authors.forename: Haixia
authors.initials: H
authors.lastname: Liu
authors.forename: Rouli
authors.initials: R
authors.lastname: Zhou
authors.forename: Ge
authors.initials: G
authors.lastname: Lou
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D015513:Oncogene Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000235:genetics*
chemical_list: C477083:LAPTM4B protein, human; D008565:Membrane Proteins; D015513:Oncogene Proteins