title: The influence of the different morphological changes on gastric mucosa on somatostatin cell number in antrum mucosa and serum somatostatin.
abstract: The aim of our paper was to investigate the influence of the different morphological changes on gastric mucosa on somatostatin D-cell number in antral mucosa and serum Somatostatin. We analyzed according to Sydney classification to what extent the severity of gastritis affect the observed hormonal values. somatostatin D-cell number in antral mucosa and serum Somatostatin values were compared between three groups of patients; mild, moderate and severe chronic gastritis. The average number of somatostatin cell in biopsy sample of antrum mucosa was 30.41 +/- 35.38 (N = 17) in the case of middle form, 18.69 +/- 26.65 (N = 56) in moderate and in severe case of chronic gastritis 5.23 +/- 5.93 (N = 7) cells in mm2 of mucosa. The level of somatostatin in the serum of middle form gastritis were 26.43 +/- 28.76, moderate 19.95 +/- 35.93 and severe 17.88 +/- 17.66 pg/mL. In order to determine the number of somatostatin cells in antrum mucosa and serum somatostatin with present morphological changes of mucosa, it might helpful to exclude the patients with non-ulcer dyspepsia, but with the higher risk of premalignant and malignant changes.
authors.affiliation: J J Strossmayer University, Osijek University Hospital Center, Department of Gastroenterology and Hepatology, Osijek, Croatia. mihaljevic.silvio@kbo.hr
authors.forename: Silvio
authors.initials: S
authors.lastname: Mihaljević
authors.forename: Miroslava
authors.initials: M
authors.lastname: Katicić
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Krznarić
authors.forename: Branko
authors.initials: B
authors.lastname: Dmitrović
authors.forename: Ivan
authors.initials: I
authors.lastname: Karner
authors.forename: Mario
authors.initials: M
authors.lastname: Stefanić
authors.forename: Ljerka
authors.initials: L
authors.lastname: Pinotić
authors.forename: Marina
authors.initials: M
authors.lastname: Samardzija
authors.forename: Mirta
authors.initials: M
authors.lastname: Bensić
mesh_terms: D015331:Cohort Studies; D005753:Gastric Mucosa / Q000166:cytology* / Q000473:pathology; D005756:Gastritis / Q000097:blood / Q000473:pathology*; D006801:Humans; D013004:Somatostatin / Q000097:blood*; D019864:Somatostatin-Secreting Cells / Q000166:cytology* / Q000473:pathology
chemical_list: D013004:Somatostatin