title: Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease.
abstract: BACKGROUND
  Celiac disease (CD) is an autoimmune disease that develops in patients with a genetic predisposition, incurring a susceptibility to gluten-containing foods such as barley, wheat, and rye. The elimination of gluten from the diet is the main therapeutic approach and usually leads to clinical and laboratory improvement. There are no ideal markers that objectively assess dietary compliance in CD patients.
  
  
  METHODS
  Sixty newly diagnosed CD patients (male/female: 43/17) and 40 healthy subjects (male/female: 23/17) were enrolled in this study. The diagnosis of CD was established by both histological findings of duodenum biopsy (total villous atrophy and lymphocytic infiltration) and positive antibodies against endomysium or gliadin.
  
  
  RESULTS
  A significantly higher mean platelet volume (MPV) was observed in the CD group compared with healthy subjects (8.45 ± 0.96 fL versus 7.93 ± 0.63 fL; p = 0.004). After introduction of a gluten-free diet, the MPV of CD patients in the dietary adherent group was significantly lower than that of the non-adherent group (8.09 ± 0.6 fL versus 8.9 ± 1.08 fL; p = 0.001). Overall dietary adherence rate was 71.6% (43/60 CD patients). In the dietary compliant group, initiation of gluten-free diet was associated with a significant decrease in MPV from base-line values (8.56 fL versus 8.25 fL; p = 0.008). In the non-adherent group, MPV on 3-month follow-up was higher than at base-line (8.05 fL versus 8.91 fL; p = 0.001).
  
  
  CONCLUSIONS
  MPV could be a promising and easily available biomarker for monitoring of dietary adherence in CD patients at a low cost in comparison with other modalities.
authors.affiliation: Department of Gastroenterology, Ankara Numune Education and Research Hospital, Samanpazari, Sihhiye/Ankara, Turkey. purnakt@yahoo.com
authors.forename: Tugrul
authors.initials: T
authors.lastname: Purnak
authors.forename: Cumali
authors.initials: C
authors.lastname: Efe
authors.forename: Osman
authors.initials: O
authors.lastname: Yuksel
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Beyazit
authors.forename: Ersan
authors.initials: E
authors.lastname: Ozaslan
authors.forename: Emin
authors.initials: E
authors.lastname: Altiparmak
mesh_terms: D000328:Adult; D015415:Biomarkers; D001792:Blood Platelets; D016022:Case-Control Studies; D002446:Celiac Disease / Q000097:blood / Q000178:diet therapy*; D048429:Cell Size; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance
chemical_list: D015415:Biomarkers