title: Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors.
abstract: A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA.
authors.forename: Jody L Major
authors.initials: JL
authors.lastname: Jourden
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Daniel
authors.forename: Seth M
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D015195:Drug Design; D006861:Hydrogen Peroxide / Q000737:chemistry*; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000737:chemistry / Q000378:metabolism; D008670:Metals / Q000378:metabolism; D011480:Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D008670:Metals; D011480:Protease Inhibitors; D006861:Hydrogen Peroxide; D020782:Matrix Metalloproteinases