title: Central nervous system control of cough: pharmacological implications.
abstract: For many years the idea of a cough center in the brain dominated discussions in the field without any substantial progress in defining what this cough center is or how it functions. Substantial progress has now been made and many of the central neural elements involved in coughing are being described. Furthermore, hypothesis driven research into the function of these neural elements is providing exciting new leads for possible therapeutic targets. The concept of a specific, centrally acting drug for cough suppression is fast becoming a reality. This review summarizes the key findings from the past few years and provides a perspective on future directions for the development of novel antitussives.
authors.affiliation: The School of Biomedical Sciences, University of Queensland, St Lucia, QLD 4072, Australia. s.mazzone@uq.edu.au
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Mazzone
authors.forename: Alice E
authors.initials: AE
authors.lastname: McGovern
authors.forename: Leonie J
authors.initials: LJ
authors.lastname: Cole
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Farrell
mesh_terms: D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology*; D003371:Cough / Q000188:drug therapy* / Q000503:physiopathology*; D055808:Drug Discovery; D006801:Humans
chemical_list: D000996:Antitussive Agents