title: Patients with familial non-medullary thyroid cancer have an outcome similar to that of patients with sporadic papillary thyroid tumors.
abstract: OBJECTIVE
  The purpose of this study was to determine whether familial non-medullary thyroid cancer (FNMTC) is more aggressive than sporadic thyroid cancer.
  
  
  METHODS
  We compared the clinical behavior and outcome of 16 subjects with FNMTC from 7 unrelated kindred with those observed in 160 subjects with sporadic PTC (SPTC) from our database.
  
  
  RESULTS
  The only different baseline characteristics observed between both groups were: bilateral malignancy, 38% vs. 24%, respectively (p = 0.03), and lymph node metastasis, 56.2% vs. 39%, respectively (p = 0.01). Considering the outcome, in the FNMTC, 9 (56.2%) patients were rendered free of disease, one patient died from thyroid cancer (6%), and 6/16 (37.5%) had persistent disease. In the SPTC Group, 87 (54%) patients were considered free of disease, 11 (7%) died due to PTC, and 62 (38%) had persistent disease (p = ns).
  
  
  CONCLUSIONS
  Despite the higher incidence of lymph node metastasis in FNMTC patients this situation seemed not to alter the compared outcome.
authors.affiliation: Division of Endocrinology, Hospital de Clinicas, University of Buenos Aires, Argentina. fpitoia@intramed.net
authors.forename: Fabián
authors.initials: F
authors.lastname: Pitoia
authors.forename: Graciela
authors.initials: G
authors.lastname: Cross
authors.forename: María E
authors.initials: ME
authors.lastname: Salvai
authors.forename: Erika
authors.initials: E
authors.lastname: Abelleira
authors.forename: Hugo
authors.initials: H
authors.lastname: Niepomniszcze
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008207:Lymphatic Metastasis; D008297:Male; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy
chemical_list: D007457:Iodine Radioisotopes