title: Association between TNF-α polymorphisms and cervical cancer risk: a meta-analysis.
abstract: Tumor necrosis factor alpha (TNF-α) is a vital cytokine involved in inflammation, immunity, and cellular organization. The TNFA-308G/A (rs1800629) and -238G/A (rs361525) polymorphisms are two widely investigated variants for their associations with risk of cervical cancer, but the results are conflicting. Here, we performed a meta-analysis to pool the data and evaluate the between-studies heterogeneity. All the case-control studies published from January 1989 to October 2010 on the association between the two polymorphisms of TNFA and cervical cancer risk were identified by searching the electronic literature Medline. The cervical cancer risk associated with the two polymorphisms of TNFA gene was estimated for each study by OR together with its 95% CI, respectively, by using the Review Manager 4.2 software. It was showed that the variant homozygote -308AA was associated with a significantly increased risk of cervical cancer (AA vs. GG: OR = 1.41, 95% CI = 1.03-1.92, P = 0.033; AA vs.
  OR = 1.39, 95% CI = 1.02-1.90, P = 0.036), and the effect was more evident among Asians (AA vs.
  OR = 3.67, 95% CI = 1.25-10.81, P = 0.018). We also found that the variant genotypes -238GA/AA was associated with a significantly decreased risk of cervical cancer (GA/AA vs. GG: OR = 0.55, 95% CI = 0.41-0.74, P < 0.001). The results suggested that TNFA-308G/A and -238G/A may contribute to cervical cancer susceptibility.
authors.affiliation: Tumor Hospital of Nantong City, Nantong 226000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Chen
authors.forename: Tinjing
authors.initials: T
authors.lastname: Kan
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Zengyan
authors.initials: Z
authors.lastname: Chen
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Hu
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha