title: Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors
abstract: The 2-fluoroalkoxy substituted catechol-aporphines 6, 8a-f and 11-monohydroxyaporphines 11a-e were synthesized and found to have high in vitro affinity and selectivity for the dopamine D(2) receptors. The catechol aporphines, 8b and 8d, and the monohydroxy aporphines, 11a-d, were identified as candidates for development as potential PET ligands.
authors.affiliation: Alcohol & Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478-9106 USA.
authors.forename: Anna W
authors.initials: AW
authors.lastname: Sromek
authors.forename: Yu-Gui
authors.initials: YG
authors.lastname: Si
authors.forename: Tangzhi
authors.initials: T
authors.lastname: Zhang
authors.forename: Susan R
authors.initials: SR
authors.lastname: George
authors.forename: Philip
authors.initials: P
authors.lastname: Seeman
authors.forename: John L
authors.initials: JL
authors.lastname: Neumeyer