title: Effect of antiretroviral drugs on the quality of semen.
abstract: The aim of this cross-sectional study was to determine which antiretroviral drugs (ARVs) are associated with changes in the characteristics of semen and the impact of these ARVs according to their score penetration into the male genital compartment. Data from 144 men infected with HIV-1 enrolled in an Assisted Reproductive Technology program were analyzed retrospectively. A seminal penetration score of ARV was based on the available literature. The nonparametric Kruskal-Wallis test and chi-square test were used. There was no difference on sperm parameters between NRTI, NNRTI, or PI regimen. In patients receiving NRTIs or PIs no differences were observed between antiretrovirals of these classes. However, in patients receiving NNRTIs, nevirapine (n = 22) was associated with a higher percentage of progressively motile spermatozoa (P < 0.0001) versus efavirenz (n = 38) as well as vitality (P = 0.0004). No relationship was observed between semen quality and the penetration score. NRTIs and PIs were not associated with any semen changes. Nevirapine was associated with a better quality of semen versus efavirenz. It would be of interest to validate, improve and test our penetration score in a prospective study.
authors.affiliation: UPMC Pierre et Marie Curie University, Paris, France. sidonie.lambert@psl.aphp.fr
authors.forename: Sidonie
authors.initials: S
authors.lastname: Lambert-Niclot
authors.forename: Catherine
authors.initials: C
authors.lastname: Poirot
authors.forename: Roland
authors.initials: R
authors.lastname: Tubiana
authors.forename: Allal
authors.initials: A
authors.lastname: Houssaini
authors.forename: Cathia
authors.initials: C
authors.lastname: Soulié
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Dominguez
authors.forename: Benoit
authors.initials: B
authors.lastname: Schubert
authors.forename: Marie
authors.initials: M
authors.lastname: Prades
authors.forename: Manuela
authors.initials: M
authors.lastname: Bonmarchand
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
authors.forename: Philippe
authors.initials: P
authors.lastname: Flandre
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.forename: Anne-Geneviève
authors.initials: AG
authors.lastname: Marcelin
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D008124:Locomotion / Q000187:drug effects; D008297:Male; D012189:Retrospective Studies; D012661:Semen / Q000187:drug effects* / Q000502:physiology*; D013094:Spermatozoa / Q000187:drug effects / Q000502:physiology
chemical_list: D019380:Anti-HIV Agents