title: Drug release from hydrazone-containing peptide amphiphiles.
abstract: Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.
authors.affiliation: Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: John B
authors.initials: JB
authors.lastname: Matson
authors.forename: Samuel I
authors.initials: SI
authors.lastname: Stupp
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels; D006835:Hydrazones / Q000737:chemistry*; D006868:Hydrolysis; D057927:Hydrophobic and Hydrophilic Interactions; D010455:Peptides / Q000737:chemistry*; D012995:Solubility
chemical_list: D004337:Drug Carriers; D005782:Gels; D006835:Hydrazones; D010455:Peptides