title: Dietary patterns and risk of adenocarcinoma of the lung in males: a factor analysis in Uruguay.
abstract: In the period 1996-2004, a hospital-based case-control study on diet and adenocarcinoma of the lung in men was conducted in Montevideo, Uruguay. The study included 200 cases and 800 controls, frequency matched on age, residence, and interviewers. Factor analysis (principal components) was used to identify the major food patterns associated with adenocarcinoma. The analysis of food groups led to the identification of 4 patterns, arbitrarily labeled as Western, starchy vegetables, prudent, and milk/coffee. Whereas the Western pattern (OR 1.94, 95% CI 1.08-3.45) and the milk/coffee pattern (OR 2.30, 95% CI 1.35-3.90) were positively associated with risk of adenocarcinoma of the lung, the starchy vegetables (OR 0.49, 95% 0.28-0.86) and prudent patterns (OR 0.54, 95% CI 0.32-0.92) were significantly protective against this malignancy. The results suggests that adenocarcinoma of the lung could be considered a different nosologic entity, compared with the other histologies of lung cancer.
authors.affiliation: Grupo de Epidemiología, Departamento de Anatomía Patológica, Facultad de Medicina, Uruguay. estefani@adinet.com.uy
authors.forename: Eduardo
authors.initials: E
authors.lastname: De Stefani
authors.forename: Alvaro L
authors.initials: AL
authors.lastname: Ronco
authors.forename: Hugo
authors.initials: H
authors.lastname: Deneo-Pellegrini
authors.forename: Pelayo
authors.initials: P
authors.lastname: Correa
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Gisele
authors.initials: G
authors.lastname: Acosta
authors.forename: María
authors.initials: M
authors.lastname: Mendilaharsu
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000517:prevention & control; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004032:Diet / Q000009:adverse effects; D005163:Factor Analysis, Statistical; D006779:Hospitals, Public; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D025341:Principal Component Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014504:Urban Health; D014583:Uruguay / Q000453:epidemiology