title: Metatypical carcinoma. A review of 327 cases.
abstract: BACKGROUND
  Metatypical cell carcinoma is a quite rare malignancy (5% of all non melanoma skin cancers), with features of basal cell carcinoma and squamous cell carcinoma. It is described as coexistence of basal cell carcinoma and squamous cell carcinoma with no transition zone between them.
  
  
  METHODS
  We performed a retrospective study of 327 consecutive patients, diagnosed for metatypical carcinoma. Statistical analysis was made to determinate most affected areas, gender prevalence, average age, presence of ulceration and infiltration, peripheral clearance rate.
  
  
  RESULTS
  A relevant difference came out between two genders. Chi-square test emphasized a relation between females and the presence of carcinoma on the scalp. In addition a strong correlation between mixed subtype and ulceration was evident. A strong relation between intermediate subtype and positive surgical margin was found; this data could identify a more aggressive behavior of intermediate type.
  
  
  CONCLUSIONS
  Differently from melanoma that usually arises on sun exposed areas, no relation was found between sun exposion and this tumor. This characteristic stresses on the importance of other risks factor apart from sun exposition.
  
  
  CONCLUSIONS
  We identify some correlation between our data that cannot be explained with previous interpretation of sun exposition.
authors.affiliation: Department of Plastic Surgery, Policlinico Umberto I, Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Tarallo
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cigna
authors.forename: Valentina
authors.initials: V
authors.lastname: Sorvillo
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Stefanizzi
authors.forename: Nicolò
authors.initials: N
authors.lastname: Scuderi
mesh_terms: D000005:Abdomen / Q000473:pathology; D000368:Aged; D000465:Algorithms; D002281:Carcinoma, Basosquamous / Q000473:pathology* / Q000628:therapy; D016009:Chi-Square Distribution; D005145:Face / Q000473:pathology; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000473:pathology; D008297:Male; D009333:Neck / Q000473:pathology; D018365:Neoplasm, Residual / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D012535:Scalp / Q000473:pathology; D012737:Sex Factors; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy; D013909:Thorax / Q000473:pathology; D034941:Upper Extremity / Q000473:pathology