title: Nonsteroidal anti-inflammatory drugs-induced generalized fixed drug eruption: two cases.
abstract: Fixed drug eruption (FDE) is a drug-induced cutaneous reaction that occurs at the same site with each exposure to a specific medication and usually manifests as round or oval, sharply demarcated erythematous or edematous plaques. The exact mechanism is unknown. The most common causative agent is co-trimoxazole. Other major categories of causative agents of FDE include antibiotics, antiepileptics, and nonsteroidal anti-inflammatory drugs (NSAIDs). FDE usually causes localized eruptions and very rarely generalized lesions. We report two cases of developing generalized FDEs after exposure to diclofenac and naproxen.
authors.affiliation: Department of Dermatology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey. drserapgunes@yahoo.com
authors.forename: Serap Gunes
authors.initials: SG
authors.lastname: Bilgili
authors.forename: O
authors.initials: O
authors.lastname: Calka
authors.forename: A S
authors.initials: AS
authors.lastname: Karadag
authors.forename: N
authors.initials: N
authors.lastname: Akdeniz
authors.forename: M
authors.initials: M
authors.lastname: Kosem
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004008:Diclofenac / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D009288:Naproxen