title: [Clinical efficacy and safety of CPT-11+CDDP therapy as third-line chemotherapy for advanced and recurrent gastric cancer].
abstract: The clinical efficacy and safety of CPT-11+CDDP therapy were studied retrospectively in 34 patients with advanced and recurrent gastric cancer. The overall response rate was 5. 9%; MST was 209 days. The adverse effects observed were grade 3 in 7 patients(20. 6%). CPT-11+CDDP therapy could be useful and safe as third-line chemotherapy.
authors.affiliation: Dept. of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama City University.
authors.forename: Ten I
authors.initials: TI
authors.lastname: Godai
authors.forename: Takashi
authors.initials: T
authors.lastname: Oshima
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Numata
authors.forename: Michiko
authors.initials: M
authors.lastname: Fukahori
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Hirochika
authors.initials: H
authors.lastname: Makino
authors.forename: Shoichi
authors.initials: S
authors.lastname: Fujii
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada
authors.forename: Chikara
authors.initials: C
authors.lastname: Kunisaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012008:Recurrence; D016879:Salvage Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015996:Survival Rate
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin