title: New neuritogenic steroidal saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl.
abstract: A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4' of the sugar, linked to C-1 of the aglycone. It exhibited significant neuritogenic activity for PC12 cells. The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Qu
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Pei
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Gao
authors.forename: Qianming
authors.initials: Q
authors.lastname: Huang
authors.forename: Makoto
authors.initials: M
authors.lastname: Ojika
authors.forename: Youji
authors.initials: Y
authors.lastname: Sakagami
authors.forename: Jianhua
authors.initials: J
authors.lastname: Qi
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000473:pathology; D000818:Animals; D002460:Cell Line; D006801:Humans; D008858:Microscopy, Phase-Contrast; D018716:Molecular Mimicry; D020932:Nerve Growth Factor / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects*; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D031441:Ophiopogon / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D010936:Plant Extracts; D012503:Saponins; D020932:Nerve Growth Factor