title: Relations between plasma ox-LDL and carotid plaque among Chinese Han ethnic group.
abstract: OBJECTIVE
  To study the relationship between plasma oxidized low-density lipoprotein (ox-LDL) and carotid plaque, including plaque stability, of patients with acute ischemic stroke among Chinese Han ethnic group.
  
  
  METHODS
  A total of 181 patients with acute ischemic stroke were recruited and enrolled. The subjects were divided into a carotid plaque group and a no-plaque group by carotid ultrasound. The stability of carotid atheromas was assessed by ultrasound echo density, and the carotid plaque group was further divided into a vulnerable plaque group and a stable plaque group based on the echo results.
  
  
  RESULTS
  The study showed that the correlation between age [odds ratio (OR): 1.047; 95% confidence interval (CI): 1.014-1.082; P<0.01] and carotid plaque was significant. Plasma ox-LDL (OR: 1.020; 95%CI: 1.010-1.030; P<0.001) was also found to be significantly correlated with carotid plaque. Age was irrelevant to plaque stability (P = 0.0685). The ox-LDL of the vulnerable plaque group was found to be significantly higher than that of the stable plaque group (P = 0.015). By measuring the plasma ox-LDL in patients with ischemic stroke, the proportion under the receiver operating characteristic curve of vulnerable carotid plaques was 0.690 with a 95%CI of 0.613-0.767 (P<0.001). The point of cut-off was 94.5943, the sensitivity was 0.805, and the specificity was 0.505.
  
  
  CONCLUSIONS
  The plasma ox-LDL level and age are possible risk factors for carotid plaque among patients with ischemic stroke of the Chinese Han ethnic group. This study suggests that ox-LDL could be used as a biomarker in screening for vulnerable carotid plaque in clinical practice.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Ruile
authors.initials: R
authors.lastname: Fang
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Chunxue
authors.initials: C
authors.lastname: Wang
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Xianwei
authors.initials: X
authors.lastname: Wang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000097:blood; D044466:Asian People / Q000208:ethnology; D002545:Brain Ischemia / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology; D016893:Carotid Stenosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020521:Stroke / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology; D014463:Ultrasonography
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein