title: Polymeric antimicrobial N-halamine epoxides.
abstract: A new N-halamine copolymer has been prepared, characterized, and evaluated for antimicrobial efficacy, stability toward hydrolyses, and stability toward UVA degradation when covalently bound to cellulose fibers. A copolymer of 3-chloro-2-hydroxypropylmethacrylate and glycidyl methacrylate was coated onto cotton, and, after curing, was treated with an aqueous solution containing the potassium salt of 5,5-dimethylhydantoin to form a coating which became antimicrobial upon exposure to househod bleach (sodium hypochlorite). The coating inactivated S. aureus and E. coli O157:H7 within minutes of contact time and was quite stable toward washing and UVA photodegradation.
authors.affiliation: Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA.
authors.forename: Hasan B
authors.initials: HB
authors.lastname: Kocer
authors.forename: Idris
authors.initials: I
authors.lastname: Cerkez
authors.forename: S D
authors.initials: SD
authors.lastname: Worley
authors.forename: R M
authors.initials: RM
authors.lastname: Broughton
authors.forename: T S
authors.initials: TS
authors.lastname: Huang
mesh_terms: D000588:Amines / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D002482:Cellulose / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry* / Q000494:pharmacology; D019453:Escherichia coli O157 / Q000187:drug effects; D006219:Halogens / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D010782:Photolysis; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012973:Sodium Hypochlorite / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D014466:Ultraviolet Rays
chemical_list: D000588:Amines; D000890:Anti-Infective Agents; D004852:Epoxy Compounds; D006219:Halogens; D008689:Methacrylates; D011108:Polymers; D002482:Cellulose; D012973:Sodium Hypochlorite