title: Effects of oral glucosamine hydrochloride administration on plasma free amino acid concentrations in dogs.
abstract: We examined the effects of oral glucosamine hydrochloride (GlcN), N-acetyl-D-glucosamine (GlcNAc) and d-glucose (Glc) administration on plasma total free amino acid (PFAA) concentrations in dogs. The PFAA concentrations increased in the control group and the GlcNAc group at one hour after feeding, and each amino acid concentration increased. On the other hand, in the GlcN group and the Glc group PFAA concentrations decreased at one hour after feeding. A significant decrease in amino acid concentration was observed for glutamate, glycine and alanine. Our results suggest the existence of differences in PFAA dynamics after oral administration of GlcN and GlcNAc in dogs.
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Azuma
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osaki
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuka
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Imagawa
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Koyo Chemical Co. Ltd., 2-11-1 Koraku, Bunkyoku, Tokyo 112-0004, Japan.
authors.forename: Yoshimori
authors.initials: Y
authors.lastname: Takamori
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Saburo
authors.initials: S
authors.lastname: Minami
mesh_terms: D000117:Acetylglucosamine / Q000494:pharmacology; D000284:Administration, Oral; D000596:Amino Acids / Q000097:blood*; D000818:Animals; D024043:Collagen Type II / Q000096:biosynthesis; D004285:Dogs; D005944:Glucosamine / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D011509:Proteoglycans / Q000096:biosynthesis
chemical_list: D000596:Amino Acids; D024043:Collagen Type II; D011509:Proteoglycans; D005947:Glucose; D005944:Glucosamine; D000117:Acetylglucosamine