title: Role of PPARgamma, a nuclear hormone receptor in neuroprotection.
abstract: Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily. PPAR-alpha is involved in wound healing, stimulation of lipid and folic acid catabolism, inflammation control, inhibition of ureagenesis and peroxisome proliferation. The PPARgamma/delta is involved wound healing, cell proliferation, embryo implantation, adipocyte differentiation, myelination alteration and apoptosis. The PPARgamma is involved in fat, lipid and calorie utilization, sugar control, inflammation control and macrophage (MQ) matutation. Homocysteine (Hcy) binds to nuclear peroxisome proliferator activated receptor. Increase in PPAR expression decreases the level of nitrotyrosine and increases endothelial nitric oxide concentration, decreases metalloproteinase activity and expression as well as elastinolysis and reverses Hcy-mediated vascular dysfunction. The PPARgamma initially recognized as a regulator of adipocyte development has become a potential therapeutic target for the treatment of diverse disorders. In addition, the activation of PPARgamma receptor ameliorates neurodegenerative disease. This review focuses on the recent knowledge of PPARgamma in neuroprotection and deals with the mechanism of neuroprotection of central nervous system disorder by PPARgamma.
authors.affiliation: Department of Physiology & Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
authors.forename: William
authors.initials: W
authors.lastname: Gillespie
authors.forename: Neetu
authors.initials: N
authors.lastname: Tyagi
authors.forename: Suresh C
authors.initials: SC
authors.lastname: Tyagi
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D016923:Cell Death; D002490:Central Nervous System / Q000166:cytology* / Q000378:metabolism* / Q000473:pathology; D019610:Cytoprotection; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D009474:Neurons / Q000166:cytology* / Q000473:pathology; D018696:Neuroprotective Agents / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism*
chemical_list: D018696:Neuroprotective Agents; D047495:PPAR gamma