title: The natural history of the overactive bladder syndrome in females: a long-term analysis of a health screening project.
abstract: OBJECTIVE
  To analyze the natural history of the overactive bladder (OAB) syndrome in women over a period of 6.5 years.
  
  
  METHODS
  Women participating in a health screening survey in the area of Vienna in 1998/1999 underwent a detailed health investigation and completed the Bristol Female Lower Urinary Tract Symptom (BFLUTS) Questionnaire. In 2005 all women who were still living in the area of Vienna, were contacted by mail to complete the BFLUTS questionnaire again.
  
  
  RESULTS
  A total of 386 women with a mean age of 54 years (range: 21-81 years) entered this study and were all followed for a mean of 6.5 years. At baseline, the prevalence of OAB was 19.4% (n = 75/386) and increased to 27.2% (105/386) 6.5 years later resulting in an average annual progression rate of 1.2%. The incidence was 19.3% (n = 60/311; average annual rate: 2.9%), a remission was seen in 40% (n = 30/75; average annual rate: 6.2%), stable disease in 41.3% (n = 31/75; average annual rate: 6.4%), a progression was noticed in 6.7% (n = 5/75; average annual rate: 1.0%) and an improvement in 12% (n = 9/75; average annual rate: 1.8%). Women with a full remission were 49.9 years (± 13 years), those with stable disease 58.2 years (± 9.3 years), those with improvement 57.4 years (± 10.4 years), those with deterioration 61.8 years (± 12.8 years) and those with de novo OAB 57.3 years (± 12.3 years).
  
  
  CONCLUSIONS
  OAB is a dynamic disease with long-lasting stable disease courses as well as remissions and progressions.
authors.affiliation: Department of Urology and Andrology, Donauspital, Donauspital, Vienna, Austria. stefan.heidler@wienkav.at
authors.forename: Stefan
authors.initials: S
authors.lastname: Heidler
authors.forename: Can
authors.initials: C
authors.lastname: Mert
authors.forename: Christian
authors.initials: C
authors.lastname: Temml
authors.forename: Stephan
authors.initials: S
authors.lastname: Madersbacher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001317:Austria / Q000453:epidemiology; D016009:Chi-Square Distribution; D018450:Disease Progression; D005260:Female; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D059411:Lower Urinary Tract Symptoms / Q000453:epidemiology; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012074:Remission Induction; D011795:Surveys and Questionnaires; D013997:Time Factors; D001743:Urinary Bladder / Q000503:physiopathology; D053201:Urinary Bladder, Overactive / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D055815:Young Adult