title: Functionalizable oligoprolines as molecular scaffolds.
abstract: Azidoproline (Azp) containing oligoprolines are conformationally well-defined, helical molecular scaffolds that allow for facile functionalization. Within this article we describe the synthesis of Azp-containing oligoprolines and different strategies to introduce functional moieties. In addition, the influence of factors such as substituents at the y-position of proline as well as functional groups at the termini on the conformational stability of the molecular scaffolds are briefly presented.
authors.affiliation: Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel.
authors.forename: Yvonne A
authors.initials: YA
authors.lastname: Nagel
authors.forename: Michael
authors.initials: M
authors.lastname: Kuemin
authors.forename: Helma
authors.initials: H
authors.lastname: Wennemers
mesh_terms: D001386:Azides / Q000737:chemistry; D008968:Molecular Conformation; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011392:Proline / Q000031:analogs & derivatives*; D017433:Protein Structure, Secondary
chemical_list: D001386:Azides; D010455:Peptides; C011083:polyproline; D011392:Proline