title: Human papillomavirus genotype distribution among French women with and without cervical abnormalities.
abstract: OBJECTIVE
  To assess human papillomavirus (HPV) prevalence and distribution among French women with normal and pathologic cytology findings.
  
  
  METHODS
  A genomic DNA microarray assay enabling the detection of 35 different HPV genotypes was used for in vitro diagnosis, as a complement to Papanicolaou screening, to test 785 women who attended the gynecology department of a hospital in Lyon, France.
  
  
  RESULTS
  Pathologic and normal cytology findings were obtained for 260 (33.1%) and 302 (38.5%) of the 785 women, respectively, whereas 223 (28.4%) results were inconclusive. HPV infection and multiple infection were significantly more prevalent (P<0.001) in the population with pathologic findings (90.0% and 41.9%, respectively) than in the population with normal cytology findings (48.3% and 20.2%, respectively). Overall, the 4 most frequent HPV genotypes were HPV-16 (14.8%), HPV-53 (9.0%), HPV-31 (8.7%), and HPV-51 (7.5%), whereas HPV-18 (3.8%), HPV-6 (2.9%), and HPV-11 (0.4%) were less common. The HPV genotypes included in the quadrivalent vaccination had a prevalence of 20.6% among all women and 30.4% among those with pathologic findings.
  
  
  CONCLUSIONS
  The present data indicate a reduced direct impact of HPV vaccination in the study population owing to a low prevalence of HPV-18 and a high prevalence of HPV-53, HPV-31, and HPV-51.
authors.affiliation: Laboratory of Virology, Femme-Mère-Enfant Hospital, Bron, France.
authors.forename: Jean-Sebastien
authors.initials: JS
authors.lastname: Casalegno
authors.forename: Mehdi
authors.initials: M
authors.lastname: Benchaib
authors.forename: Karine
authors.initials: K
authors.lastname: Le Bail Carval
authors.forename: Eric
authors.initials: E
authors.lastname: Piaton
authors.forename: Patrice
authors.initials: P
authors.lastname: Mathevet
authors.forename: Yahia
authors.initials: Y
authors.lastname: Mekki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002584:Cervix Uteri / Q000002:abnormalities* / Q000821:virology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D055815:Young Adult