title: Antiretroviral therapy in intensive care.
abstract: Using antiretroviral therapy (ART) raises numerous issues in intensive care units (ICU): drug administration and kinetics issues in ventilated patients and/or with gastric tube, drug interactions, and risk of immune reconstitution inflammatory syndrome. This is why a lot of ICU physicians stop ART on admission and few initiate it during the ICU stay. However, the literature review suggests that the earlier the ART is started the more effective it is. Furthermore, stopping ART could be hazardous for some patients. The authors present the most frequent issues raised by ART use in an ICU and how to deal with them.
authors.affiliation: Infectious and tropical diseases unit, CHU d'Amiens, place Victor-Pauchet, Amiens, France. lanoix.jean-philippe@chu-amiens.fr
authors.forename: J-P
authors.initials: JP
authors.lastname: Lanoix
authors.forename: C
authors.initials: C
authors.lastname: Andrejak
authors.forename: J-L
authors.initials: JL
authors.lastname: Schmit
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism / Q000628:therapy; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000075202:Contraindications; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness; D003663:Decision Trees; D004304:Dosage Forms; D004333:Drug Administration Routes; D004334:Drug Administration Schedule; D004347:Drug Interactions; D004363:Drug Utilization; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D017093:Liver Failure / Q000378:metabolism / Q000628:therapy; D017582:Renal Replacement Therapy; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D004304:Dosage Forms