title: [Calcium pyrophosphate deposition disease].
abstract: Definitive diagnosis of chondrocalcinosis (CC) is allowed by identification of calcium pyrophosphate (CPP) crystals in synovial fluid. In daily practice, X-Rays are the most frequent imaging used to detect CC. Most cases of CC are sporadic. If CC occurs before 60 years of age, primary metabolic disorders such as hyperparathyroidism, hypomagnesemia, and hemochromatosis or a familial predisposition should be particularly considered. Treatment of CPP arthritis includes application of ice, rest, joint aspiration and intra-articular injection of corticosteroids. Oral NSAIDs can be used cautiously, in particular in the elderly. Prophylaxis against frequent recurrent acute CPP crystal arthritis can be achieved with low-dose oral colchicine.
authors.affiliation: Université Paris 7, UFR médicale, Assistance publique-Hôpitaux de Paris, hôpital Lariboisière, fédération de rhumatologie, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France. pascal.richette@lrb.aphp.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Richette
authors.forename: Thomas
authors.initials: T
authors.lastname: Bardin
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D002131:Calcium Pyrophosphate / Q000378:metabolism*; D002805:Chondrocalcinosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D003078:Colchicine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011859:Radiography; D012307:Risk Factors; D055502:Secondary Prevention; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006074:Gout Suppressants; D003078:Colchicine; D002131:Calcium Pyrophosphate