title: Blood biomarkers of ischemic stroke.
abstract: This review provides a summary of the protein and RNA biomarkers that have been studied for the diagnosis and assessment of ischemic stroke. Many of the biomarkers identified relate to the pathophysiology of ischemic stroke, including ischemia of CNS tissue, acute thrombosis and inflammatory response. These biomarkers are summarized by their intended clinical application in ischemic stroke including diagnosis, prediction of stroke severity and outcome, and stratification of patients for stroke therapy. Among the biomarkers discussed are recent whole genome studies using RNA expression profiles to diagnose ischemic stroke and stroke etiology. Though many candidate blood based biomarkers for ischemic stroke have been identified, none are currently used in clinical practice. With further well designed study and careful validation, the development of blood biomarkers to improve the care of patients with ischemic stroke may be achieved.
authors.affiliation: Department of Neurology and MIND Institute, University of California at Davis, Sacramento, CA 95817, USA. gcjickling@ucdavis.edu
authors.forename: Glen C
authors.initials: GC
authors.lastname: Jickling
authors.forename: Frank R
authors.initials: FR
authors.lastname: Sharp
mesh_terms: D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism; D002545:Brain Ischemia / Q000150:complications; D056424:Decompressive Craniectomy / Q000379:methods; D006801:Humans; D012313:RNA / Q000097:blood; D020521:Stroke / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D012313:RNA