title: Sporadic Burkitt lymphoma in southern China: 12 years' experience in a single institution in Guangzhou.
abstract: OBJECTIVE
  To analyse the clinicopathological features of sporadic Burkitt lymphoma (sBL).
  
  
  METHODS
  In a review of 1682 cases of non-Hodgkin lymphoma diagnosed in the First Affiliated Hospital and Zhongshan School of Medicine, from 1998 to 2010, 20 cases (1.2%) of sBL were identified. Histopathological examination, immunohistochemistry and in situ hybridisation were used to analyse the clinicopathological features of these cases.
  
  
  RESULTS
  Of the 20 cases of sBL, 18 patients were male and two were female. The mean age was 18 years (range 2-67 years). Extranodal presentation was more common than nodal presentation (55% vs 15%). Histopathologically, 18 cases (90%) showed monotonous medium-sized tumour cells, and two cases showed cells that were slightly pleomorphic in nuclear size and shape. Immunophenotypically, MUM1 was positive in three of 17 cases (17.6%). EBER expression was shown in five of 17 cases (29.4%), and all EBER-positive sBLs were Bcl-6+/MUM1-.
  
  
  CONCLUSIONS
  sBL is rare and mainly affects male children, with predominantly extranodal presentation. MUM1 expression was found in some sBLs. EBER expression was found in 29.4% of sBLs from southern China, an area with a well-known high incidence of nasopharyngeal carcinoma, which is closely associated with Epstein-Barr virus infection.
authors.affiliation: Department of Pathology, the First Affiliated Hospital and Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Ziyin
authors.initials: Z
authors.lastname: Ye
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Xiao
authors.forename: Huijuan
authors.initials: H
authors.lastname: Shi
authors.forename: Zunfu
authors.initials: Z
authors.lastname: Ke
authors.forename: Yongdong
authors.initials: Y
authors.lastname: Liu
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Liang
authors.forename: Anjia
authors.initials: A
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002051:Burkitt Lymphoma / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004268:DNA-Binding Proteins / Q000378:metabolism; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D050835:Interferon Regulatory Factors / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D051560:Proto-Oncogene Proteins c-bcl-6; D016601:RNA-Binding Proteins / Q000378:metabolism; D012269:Ribosomal Proteins / Q000378:metabolism; D055815:Young Adult; D000099218:Interferon Regulatory Factor-4
chemical_list: D004268:DNA-Binding Proteins; D050835:Interferon Regulatory Factors; D051560:Proto-Oncogene Proteins c-bcl-6; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; D000099218:Interferon Regulatory Factor-4; C084103:BCL6 protein, human; C067169:RPL22 protein, human