title: Synthesis of substituted pyrazoles via tandem cross-coupling/electrocyclization of enol triflates and diazoacetates.
abstract: The synthesis of 3,4,5-trisubstituted pyrazoles via a tandem catalytic cross-coupling/electrocyclization of enol triflates and diazoacetates is presented. The initial scope of this methodology is demonstrated on a range of differentially substituted acyclic and cyclic enol triflates as well as an elaborated set of diazoacetates to provide the corresponding pyrazoles with a high degree of structural complexity.
authors.affiliation: Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Babinski
authors.forename: Hector R
authors.initials: HR
authors.lastname: Aguilar
authors.forename: Raymond
authors.initials: R
authors.lastname: Still
authors.forename: Doug E
authors.initials: DE
authors.lastname: Frantz
mesh_terms: D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry; D003500:Cyclization; D003979:Diazonium Compounds / Q000737:chemistry*; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003432:Cross-Linking Reagents; D003979:Diazonium Compounds; D011720:Pyrazoles