title: Anti-depression effects of Danggui-Shaoyao-San, a fixed combination of Traditional Chinese Medicine, on depression model in mice and rats.
abstract: Anti-depression effects of Danggui-Shaoyao-San (DSS, 1.8-7.2g/kg, orally), a famous Chinese compound prescription with a fixed combination, on forced swimming test (FST) and chronic unpredictable mild stress (CUMS) model were investigated. DSS (7.2g/kg, orally, 7 days) shortened immobility time in FST model and DSS (3.6 or 7.2g/kg, orally, 21 days) increased the open-field activities and the percentage of sugar preference in CUMS model. DSS (7.2g/kg, orally, 21 days) also decreased the content of arginine vasopressin (AVP) in the pituitary and the expression of AVP mRNA in hypothalamus compared with the stress control group. These results demonstrated for the first time DSS has anti-depression effect and it may be influencing the central AVP system.
authors.affiliation: Department of Chinese Compound Prescription, China Pharmaceutical University, Nanjing 210038, PR China.
authors.forename: Fan
authors.initials: F
authors.lastname: Xu
authors.forename: Daiyin
authors.initials: D
authors.lastname: Peng
authors.forename: Chunlei
authors.initials: C
authors.lastname: Tao
authors.forename: Dengke
authors.initials: D
authors.lastname: Yin
authors.forename: Junping
authors.initials: J
authors.lastname: Kou
authors.forename: Danni
authors.initials: D
authors.lastname: Zhu
authors.forename: Boyang
authors.initials: B
authors.lastname: Yu
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001127:Arginine Vasopressin / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; C531150:danggui-shaoyao-san; D001127:Arginine Vasopressin