title: [Polymorphic variants of ALOX5AP gene and the risk of acute stroke development in the Russian population].
abstract: A protein capable of activating 5-lipoxygenase (ALOX5AP) is considered a presumable risk factor of acute stroke development. Polymorphic variants of the ALOX5AP gene were examined. Two ALOX5AP gene polymorphisms (SG13S114 (rs10507391) and SG13S32 (rs9551963)), which previously had shown association with the risk of ischemic stroke in other populations, were studied. These single nucleotide polymorphisms were analyzed using a sample of acute stroke patients (N = 1320) and a control sample (N = 467). No statistically significant associations were found between acute stroke and the ALOX5AP gene polymorphisms examined.
authors.forename: E A
authors.initials: EA
authors.lastname: Bondarenko
authors.forename: P A
authors.initials: PA
authors.lastname: Slominskiĭ
authors.forename: S A
authors.initials: SA
authors.lastname: Limborskaia
authors.forename: I M
authors.initials: IM
authors.lastname: Shetova
authors.forename: D Yu
authors.initials: DY
authors.lastname: Timofeev
authors.forename: V I
authors.initials: VI
authors.lastname: Skvortsova
mesh_terms: D058927:5-Lipoxygenase-Activating Proteins / Q000235:genetics*; D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*
chemical_list: D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human