title: Elevated plasma myeloperoxidase levels in relation to circulating inflammatory markers in coronary artery disease.
abstract: OBJECTIVE
  Elevation of the leukocyte enzyme myeloperoxidase (MPO) in stable coronary artery disease (CAD) is controversial and its relationship with oxidized low-density lipoprotein (ox-LDL) and nitrite/nitrate (NOx) levels in CAD patients has not been evaluated. Therefore, we sought to evaluate these relationships.
  
  
  METHODS
  This study included 50 stable CAD patients, 50 unstable CAD patients and 50 control subjects. Plasma MPO and ox-LDL levels were determined using enzyme immunoassay. Plasma NOx and other risk factors were also measured in the patients.
  
  
  RESULTS
  Plasma MPO levels were higher in unstable CAD patients (71.2 ± 19.6 ng/ml) than in stable CAD patients (34.5 ± 6.8 ng/ml) and control subjects (23.0 ± 3.6 ng/ml) (p < 0.001). Furthermore, plasma MPO was positively correlated with ox-LDL and negatively correlated with NOx levels (p < 0.05).
  
  
  CONCLUSIONS
  Plasma MPO levels were elevated in CAD patients and its relation to CAD may be through the oxidation of LDL and reduction of NO levels.
authors.affiliation: Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy & Pharmaceutical Sciences, Isfahan University of Medical Sciences, Iran.
authors.forename: Saed Ziaaldin
authors.initials: SZ
authors.lastname: Samsamshariat
authors.forename: Gholam
authors.initials: G
authors.lastname: Basati
authors.forename: Ahmad
authors.initials: A
authors.lastname: Movahedian
authors.forename: Morteza
authors.initials: M
authors.lastname: Pourfarzam
authors.forename: Nizal
authors.initials: N
authors.lastname: Sarrafzadegan
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000097:blood*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; D009566:Nitrates; D009573:Nitrites; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein; D009195:Peroxidase