title: Global gene expression profiles for the growth phases of Trichophyton rubrum.
abstract: Trichophyton rubrum (T. rubrum) is a common superficial fungus. Molecular and genetic studies of T. rubrum are still limited. In this paper, we report the global analysis of gene expression profiles at different growth phases using cDNA microarray technology. A total of 2044 differentially expressed genes were obtained and clustered into three expression patterns. Our data confirmed previous results that many mRNAs were pre-stored in the conidia of T. rubrum. Transcriptional profiling and function analysis showed that some glycolytic enzymes share similar expression patterns and may be coregulated during the transition of growth phases. Some genes involved in small GTPase signaling pathways, and in cAMP-dependent and MAPK regulation pathways were induced in response to the growth dynamics of T. rubrum. Although the detailed biological roles of these T. rubrum genes are still unknown, our results suggest that these genes may be involved in regulation mechanisms in the life cycle of the fungus.
authors.affiliation: Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, and State Key Laboratory of Agrobiotechnology, College of Veterinary Medicine, China Agricultural University, Beijing, 100094, China.
authors.forename: XingYe
authors.initials: X
authors.lastname: Xu
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: WenChuan
authors.initials: W
authors.lastname: Leng
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Ying
authors.initials: Y
authors.lastname: Xue
authors.forename: HanChun
authors.initials: H
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Jin
mesh_terms: D016000:Cluster Analysis; D020869:Gene Expression Profiling / Q000379:methods*; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D015203:Reproducibility of Results; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014249:Trichophyton / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism