title: Inappropriate antidiuretic hormone secretion: long-term successful urea treatment.
abstract: Hyponatremia is the main complication of inappropriate antidiuretic hormone secretion (SIADH), sometimes fatal. Treatment strategy depends on the cause and the severity of the hyponatremia. Recent studies have shown the efficacy of urea in treating acute hyponatremia secondary to SIADH, by inducing an osmotic water drive. We describe an infant with chronic hyponatremia secondary to SIADH in which the long-term oral treatment with urea was successful and well tolerated. The aim of this paper is to highlight the potential benefits of urea treatment in case of chronic hyponatremia secondary to SIADH.
  
  
  CONCLUSIONS
  Chronic oral urea treatment in children with SIADH allows an easy and safe water and sodium control and may permit a decrease in fluid restriction in this situation.
authors.affiliation: Paediatric Department, Paediatric Nephrology Unit, University Hospital, Lausanne, Switzerland. hassib.chehade@chuv.ch
authors.forename: Hassib
authors.initials: H
authors.lastname: Chehade
authors.forename: Luigi
authors.initials: L
authors.lastname: Rosato
authors.forename: Eric
authors.initials: E
authors.lastname: Girardin
authors.forename: Francois
authors.initials: F
authors.lastname: Cachat
mesh_terms: D002675:Child, Preschool; D002908:Chronic Disease; D004234:Diuretics, Osmotic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy* / Q000209:etiology; D007177:Inappropriate ADH Syndrome / Q000150:complications*; D007223:Infant; D007231:Infant, Newborn; D008134:Long-Term Care; D016896:Treatment Outcome; D014508:Urea / Q000627:therapeutic use*
chemical_list: D004234:Diuretics, Osmotic; D014508:Urea