title: Clinical outcomes of prostate cancer patients detected by prostate-specific antigen-based population screening in Kanazawa City, Japan.
abstract: OBJECTIVE
  Most common population screening systems for prostate cancer are administered by municipal governments in Japan. These systems suffer from difficulties in adequate follow up of patients at several urology departments in the region. We analyzed the clinical characteristics and outcomes of prostate cancer patients detected in our prostate-specific antigen (PSA)-based population screen, and examined the efficiency of the system.
  
  
  METHODS
  Since 2000, we have carried out PSA-based population screening in men aged 55-69 years. For the present study, primary treatments and clinical outcomes of prostate cancer patients diagnosed by this screening program were obtained from each urology department in the region.
  
  
  RESULTS
  A total of 32,769 men participated in this screening program from 2000 to 2006. Overall, 249 cases (0.76%) of prostate cancer were diagnosed. The rate of patients within gray zone levels of serum total PSA on primary screening increased and this was significantly higher in 2003 than in the first 2 years of the program. Clinical T stage was defined in 247 patients (99.2%), and 231 (93.5%) were cases of clinically localized cancer. A total of 75% of these patients underwent radical treatment. Eight-year cause-specific and overall survivals were 97.5% and 93.3%, respectively. Four patients, all of them presenting with advanced disease at diagnosis, died from prostate cancer.
  
  
  CONCLUSIONS
  The present study showed good clinical outcomes for screening-detected prostate cancer patients and it showed the effectiveness of our screening system.
authors.affiliation: Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan. yasukita@med.kanazawa-u.ac.jp
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizokami
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Nakashima
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Koshida
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Shimamura
authors.forename: Kimiomi
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Nobu
authors.initials: N
authors.lastname: Koyama
authors.forename: Mikio
authors.initials: M
authors.lastname: Namiki
mesh_terms: D000368:Aged; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis*; D012189:Retrospective Studies; D014504:Urban Health
chemical_list: D017430:Prostate-Specific Antigen