title: The Chitranjan Ranawat award: is neutral mechanical alignment normal for all patients? The concept of constitutional varus.
abstract: BACKGROUND
  Most knee surgeons have believed during TKA neutral mechanical alignment should be restored. A number of patients may exist, however, for whom neutral mechanical alignment is abnormal. Patients with so-called "constitutional varus" knees have had varus alignment since they reached skeletal maturity. Restoring neutral alignment in these cases may in fact be abnormal and undesirable and would likely require some degree of medial soft tissue release to achieve neutral alignment.
  
  
  OBJECTIVE
  We investigated what percentage of the normal population has constitutional varus knees and what are the contributing factors.
  
  
  METHODS
  We recruited a cohort of 250 asymptomatic adult volunteers between 20 and 27 years old for this cross-sectional study. All volunteers had full-leg standing digital radiographs on which 19 alignment parameters were analyzed. The incidence of constitutional varus alignment was determined and contributing factors were analyzed using multivariate prediction models.
  
  
  RESULTS
  Thirty-two percent of men and 17% of women had constitutional varus knees with a natural mechanical alignment of 3° varus or more. Constitutional varus was associated with increased sports activity during growth, increased femoral varus bowing, an increased varus femoral neck-shaft angle, and an increased femoral anatomic mechanical angle.
  
  
  CONCLUSIONS
  An important fraction of the normal population has a natural alignment at the end of growth of 3° varus or more. This might be a consequence of Hueter-Volkmann's law. Restoration of mechanical alignment to neutral in these cases may not be desirable and would be unnatural for them.
authors.affiliation: Department of Orthopaedic Surgery, University Hospital Pellenberg, Weligerveld 1, 3012 Pellenberg, Belgium. johan.bellemans@skynet.be
authors.forename: Johan
authors.initials: J
authors.lastname: Bellemans
authors.forename: William
authors.initials: W
authors.lastname: Colyn
authors.forename: Hilde
authors.initials: H
authors.lastname: Vandenneucker
authors.forename: Jan
authors.initials: J
authors.lastname: Victor
mesh_terms: D000328:Adult; D000886:Anthropometry; D001363:Awards and Prizes; D017760:Bone Malalignment / Q000000981:diagnostic imaging*; D060905:Coxa Vara / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D005260:Female; D006621:Hip Joint / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D006801:Humans; D007719:Knee Joint / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D011859:Radiography; D016059:Range of Motion, Articular / Q000502:physiology*; D012016:Reference Values; D012680:Sensitivity and Specificity; D055815:Young Adult