title: Isolation of chemical constituents from the aerial parts of Verbascum thapsus and their antiangiogenic and antiproliferative activities.
abstract: Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhao
authors.forename: Si-Feng
authors.initials: SF
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Qiu-Xia
authors.initials: QX
authors.lastname: He
authors.forename: Ke-Chun
authors.initials: KC
authors.lastname: Liu
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Yang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Li
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D004625:Embryo, Nonmammalian / Q000187:drug effects; D020834:Ethnopharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology; D047311:Luteolin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D012502:Sapogenins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism; D032265:Verbascum / Q000737:chemistry*; D015027:Zebrafish
chemical_list: C561628:3-O-fucopyranosylsaikogenin F; D020533:Angiogenesis Inhibitors; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D039823:Iridoids; D012502:Sapogenins; D012503:Saponins; D047311:Luteolin