title: A single dose of an inhibitor of cyclooxygenase 2, meloxicam, administered shortly after irradiation increases survival of lethally irradiated mice.
abstract: This study extends earlier findings of the authors demonstrating that meloxicam, a selective inhibitor of cyclooxygenase 2, supports hematopoietic recovery in sublethally irradiated mice and is radioprotective when given before irradiation. We report here that when meloxicam was administered in a single dose 1 h after a lethal 9-Gy whole-body dose, an increased 30-day survival was achieved. Additional studies showed that administration of meloxicam 24 h after lethal irradiation is ineffective and its repeated administration deleterious. Possible mechanisms of the therapeutic effects of meloxicam administered early after irradiation are discussed.
authors.affiliation: Laboratory of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, CZ-61265 Brno, Czech Republic. hofer@ibp.cz
authors.forename: M
authors.initials: M
authors.lastname: Hofer
authors.forename: M
authors.initials: M
authors.lastname: Pospíšil
authors.forename: L
authors.initials: L
authors.lastname: Dušek
authors.forename: Z
authors.initials: Z
authors.lastname: Hoferová
authors.forename: L
authors.initials: L
authors.lastname: Weiterová
mesh_terms: D000818:Animals; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood; D008297:Male; D000077239:Meloxicam; D051379:Mice; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016019:Survival Analysis; D013843:Thiazines / Q000008:administration & dosage / Q000494:pharmacology*; D013844:Thiazoles / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014916:Whole-Body Irradiation / Q000009:adverse effects
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D011837:Radiation-Protective Agents; D013843:Thiazines; D013844:Thiazoles; D016179:Granulocyte Colony-Stimulating Factor; D051546:Cyclooxygenase 2; D000077239:Meloxicam