title: RNASEL Asp541Glu and Arg462Gln polymorphisms in prostate cancer risk: evidences from a meta-analysis.
abstract: Epidemiological studies have evaluated the association between RNASEL Asp541Glu and Arg462Gln polymorphisms and prostate cancer (PCa) risk. However, the results remain inconclusive. To derive a more precise estimation of the association between RNASEL polymorphisms and PCa risk, we performed a meta-analysis based on nineteen case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Overall, we found that both Asp541Glu and Arg462Gln polymorphisms were not associated with PCa risk (for Asp541Glu polymorphism: Glu/Glu vs. Asp/Asp: OR 1.17, 95% CI: 0.95-1.45, P = 0.13; Glu/Asp vs. Asp/Asp: OR 1.02, 95% CI: 0.92-1.14, P = 0.70; for Arg462Gln polymorphism: Gln/Gln vs. Arg/Arg: OR 0.98, 95% CI: 0.88-1.08, P = 0.62; Gln/Arg vs. Arg/Arg: OR 0.97, 95% CI: 0.91-1.04, P = 0.53). The insignificant association was maintained in the dominant and the recessive genetic models. In subgroup analyses, the significant association was not detected in Caucasian populations. However, we found the significant association of RNASEL Asp541Glu polymorphism with sporadic PCa (Glu/Glu vs. Asp/Asp: OR 1.29, 95% CI: 1.04-1.59, P = 0.02; Glu/Asp vs. Asp/Asp: OR 1.24, 95% CI: 1.03-1.50, P = 0.03). In conclusion, we found that these RNASEL polymorphisms were not related to overall PCa risk, especially in Caucasians. However, in subgroup analyses we found a suggestion that RNASEL 541Gln allele might be a low-penetrent risk factor for sporadic PCa.
authors.affiliation: Department of Urology, Affiliated Wuxi People's Hospital of Nanjing Medical University, 299 Qingyang Road, Wuxi 214023, China. dr.wei@hotmail.com
authors.forename: Bingbing
authors.initials: B
authors.lastname: Wei
authors.forename: Zhuoqun
authors.initials: Z
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Ruan
authors.forename: Ming
authors.initials: M
authors.lastname: Zhu
authors.forename: Ke
authors.initials: K
authors.lastname: Jin
authors.forename: Deqi
authors.initials: D
authors.lastname: Zhou
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Yan
authors.forename: Feng
authors.initials: F
authors.lastname: Xuan
authors.forename: Hongyi
authors.initials: H
authors.lastname: Zhou
authors.forename: Xing
authors.initials: X
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Lu
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Shao
mesh_terms: D016022:Case-Control Studies; D004722:Endoribonucleases / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D020125:Mutation, Missense / Q000235:genetics; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease