title: Repeat traumatic brain injury in the developing brain.
abstract: The Center for Disease Control estimates that there are 1.7 million brain injuries in the US each year with 51% of these injuries occurring during periods of cerebral development. Among this population there is a growing population of individuals with repeat traumatic brain injury (RTBI). While the exact incidence is unknown, estimates range from 5.6 to 36% of the TBI population. This review summarizes the clinical problems/challenges and experimental research models that currently exist. It is intended to reveal the critical areas that need to be addressed so that age-relevant clinical management guidelines can be established to protect this population.
authors.affiliation: UCLA David Geffen School of Medicine, Department of Neurosurgery, United States. mprins@mednet.ucla.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Prins
authors.forename: C C
authors.initials: CC
authors.lastname: Giza
mesh_terms: D000375:Aging / Q000473:pathology*; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D012008:Recurrence