title: Association between genital intraepithelial lesions and anal squamous intraepithelial lesions in HIV-negative women.
abstract: OBJECTIVE
  The objective of the study was to evaluate the risk of anal squamous intraepithelial lesions (ASILs) in immunocompetent women with genital squamous intraepithelial lesions (GSILs).
  
  
  METHODS
  This was a cross-sectional study that included 260 immunocompetent women divided into 2 study groups: 1 group included 184 women diagnosed with GSIL by genital colposcopy and biopsy, and the other included 76 controls. All subjects were submitted to anoscopy followed by a biopsy if pertinent.
  
  
  RESULTS
  Of 184 GSIL women, 32 (17.4%) had ASIL (P<.001). The risk of ASIL was 13.1 times greater for GSIL women when there were 3 or 4 genital sites involved. All cases of high-grade ASIL were found in women with cervical GSILs. Among risk factors, anal intercourse without a condom demonstrated an important association with ASIL (prevalence ratio adjusted for age=2.6).
  
  
  CONCLUSIONS
  There seems to be a strong association between ASIL and multicentric GSIL. Another factor related to ASIL was the practice of unprotected anal intercourse.
authors.affiliation: Souza Marques University, Rio de Janeiro, Brazil. jacyntho@jacyntho.com.br
authors.forename: Cláudia M A
authors.initials: CM
authors.lastname: Jacyntho
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Giraldo
authors.forename: Antônio A
authors.initials: AA
authors.lastname: Horta
authors.forename: Rosana
authors.initials: R
authors.lastname: Grandelle
authors.forename: Ana K
authors.initials: AK
authors.lastname: Gonçalves
authors.forename: Thaís
authors.initials: T
authors.lastname: Fonseca
authors.forename: José
authors.initials: J
authors.lastname: Eleutério
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001005:Anus Neoplasms / Q000453:epidemiology* / Q000473:pathology; D001707:Biopsy, Needle; D001938:Brazil / Q000453:epidemiology; D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D003127:Colposcopy / Q000379:methods; D015897:Comorbidity; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000453:epidemiology* / Q000473:pathology; D018023:HIV Seronegativity; D006801:Humans; D007121:Immunocompetence; D015994:Incidence; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011351:Proctoscopy / Q000379:methods; D018570:Risk Assessment; D012725:Sexual Behavior; D012959:Socioeconomic Factors; D055815:Young Adult