title: Brain tissue volume changes following weight gain in adults with anorexia nervosa.
abstract: OBJECTIVE
  To measure brain volume deficits among underweight patients with anorexia nervosa (AN) compared to control participants and evaluate the reversibility of these deficits with short-term weight restoration.
  
  
  METHODS
  Brain volume changes in gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were examined in 32 adult women with AN and compared to 21, age and body mass index-range matched control women.
  
  
  RESULTS
  Patients with AN had a significant increase in GM (p = .006, η(2) = 0.14) and WM volume (p = .001, η(2) = 0.19) following weight restoration. Patients on average had lower levels of GM at low weight (647.63 ± 62.07 ml) compared to controls (679.93 ± 53.31 ml), which increased with weight restoration (662.64 ± 69.71 ml), but did not fully normalize.
  
  
  CONCLUSIONS
  This study suggests that underweight adult patients with AN have reduced GM and WM volumes that increase with short-term weight restoration.
authors.affiliation: Department of Psychology, Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06520, USA. christina.roberto@yale.edu
authors.forename: Christina A
authors.initials: CA
authors.lastname: Roberto
authors.forename: Laurel E S
authors.initials: LE
authors.lastname: Mayer
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brickman
authors.forename: Anna
authors.initials: A
authors.lastname: Barnes
authors.forename: Jordan
authors.initials: J
authors.lastname: Muraskin
authors.forename: Lok-Kin
authors.initials: LK
authors.lastname: Yeung
authors.forename: Jason
authors.initials: J
authors.lastname: Steffener
authors.forename: Melissa
authors.initials: M
authors.lastname: Sy
authors.forename: Joy
authors.initials: J
authors.lastname: Hirsch
authors.forename: Yaakov
authors.initials: Y
authors.lastname: Stern
authors.forename: B Timothy
authors.initials: BT
authors.lastname: Walsh
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000473:pathology*; D015992:Body Mass Index; D001835:Body Weight; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D009929:Organ Size; D015430:Weight Gain