title: miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype.
abstract: Decreased expression of miRNAs of the miR-200 family has been implicated in the growth and metastasis of breast cancer cells. Of this family, miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2, mediators of epithelial- mesenchymal transition. An article in the previous issue of Breast Cancer Research identifies additional targets of miR-200c that link increased cancer cell invasiveness, resistance to apoptosis, and induction of breast cancer stem cell characteristics.
authors.forename: Derek C
authors.initials: DC
authors.lastname: Radisky
mesh_terms: D023102:Anoikis; D001943:Breast Neoplasms / Q000378:metabolism*; D002465:Cell Movement; D016889:Endometrial Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*
chemical_list: D035683:MicroRNAs