title: Fructooligosaccharides suppress high-fat diet-induced fat accumulation in C57BL/6J mice.
abstract: Two experiments were performed to examine the effects of fructooligosaccharides (FOS) on the development of obesity. In the first experiment, Wistar rats were orally administered a 2.5 g/kg body weight lipid emulsion containing FOS, and the subsequent elevation of plasma triglycerides was significantly suppressed compared with that in rats receiving lipid emulsion alone. In the second experiment, C57BL/6J male mice were fed a high-fat "western" diet with or without 2.5% FOS supplementation (n = 10/group) ad libitum for 12 weeks. Body weight and percent body fat were lower in mice fed FOS than in controls. Furthermore, the weight of the visceral adipose tissue, and the weight and triglyceride content of the liver were significantly lower in the high-fat + FOS group. Fecal excretion of lipids was markedly enhanced by FOS consumption. These results indicate that dietary FOS suppress high-fat diet-induced body fat accumulation, and inhibit intestinal absorption of dietary fat.
authors.affiliation: Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Saitama, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Saitama, Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Natsume
authors.affiliation: Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Saitama, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Yasuda
authors.affiliation: Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Saitama, Japan.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Ishizaka
authors.affiliation: Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Saitama, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kawahata
authors.affiliation: Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., Saitama, Japan.
authors.forename: Jinichiro
authors.initials: J
authors.lastname: Koga
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements; D002149:Energy Intake / Q000187:drug effects*; D006801:Humans; D051379:Mice; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000473:pathology; D009844:Oligosaccharides / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood*
chemical_list: D009844:Oligosaccharides; D014280:Triglycerides; C116580:fructooligosaccharide