title: Unique role of ionic liquid [bmin][BF4] during curcumin-surfactant association and micellization of cationic, anionic and non-ionic surfactant solutions.
abstract: Hydrophilic ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroburate, modified the properties of aqueous surfactant solutions associated with curcumin. Because of potential pharmaceutical applications as an antioxidant, anti-inflammatory and anti-carcinogenic agent, curcumin has received ample attention as potential drug. The interaction of curcumin with various charged aqueous surfactant solutions showed it exists in deprotonated enol form in surfactant solutions. The nitro and hydroxyl groups of o-nitrophenol interact with the carbonyl and hydroxyl groups of the enol form of curcumin by forming ground state complex through hydrogen bonds and offered interesting information about the nature of the interactions between the aqueous surfactant solutions and curcumin depending on charge of head group of the surfactant. IL[bmin][BF4] encouraged early formation of micelle in case of cationic and anionic aqueous surfactant solutions, but slightly prolonged micelle formation in the case of neutral aqueous surfactant solution. However, for curcumin IL [bmin][BF4] favored strong association (7-fold increase) with neutral surfactant solution, marginally supported association with anionic surfactant solution and discouraged (∼2-fold decrease) association with cationic surfactant solution.
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, American University of Beirut, P.O. Box: 11-0236, Riad El Solh, Beirut, 1107-2020, Lebanon. dp03@aub.edu.lb
authors.forename: Digambara
authors.initials: D
authors.lastname: Patra
authors.forename: Christelle
authors.initials: C
authors.lastname: Barakat
mesh_terms: D000838:Anions / Q000737:chemistry*; D016588:Anticarcinogenic Agents / Q000737:chemistry* / Q000378:metabolism; D002412:Cations / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry* / Q000378:metabolism; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry*; D052578:Ionic Liquids; D008823:Micelles; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry* / Q000378:metabolism; D014867:Water / Q000737:chemistry
chemical_list: C419324:1-butyl-3-methylimidazolium tetrafluoroborate; D000838:Anions; D016588:Anticarcinogenic Agents; D002412:Cations; D007093:Imidazoles; D052578:Ionic Liquids; D008823:Micelles; D013501:Surface-Active Agents; D014867:Water; D003474:Curcumin