title: No association between BDNF Val66Met polymorphism and emergence of psychiatric symptoms in systemic lupus erythematosus patients.
abstract: BACKGROUND
  Brain-derived neurotrophic factor (BDNF) plays an important role in the regulation of synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. Recent studies have suggested that BDNF plays a role in the pathogenesis of psychiatric symptoms in patients with systemic lupus erythematosus (SLE).
  
  
  OBJECTIVE
  We hypothesized that the polymorphism of BDNF Val66Met is associated with the emergence of psychiatric symptoms (PS) and serum BDNF levels in SLE patients. To examine the hypothesis, we compared the BDNF Val66Met polymorphism and serum BDNF levels in patients with SLE with or without PS.
  
  
  METHODS
  Psychiatric symptoms were assessed in 54 patients with SLE. PS were evaluated using the Brief Psychiatric Rating Scale. Genotyping was carried out using a 54-nuclease assay. Serum BDNF levels were measured by using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The presence of the Met allele was not significantly associated with the presence of PS or with serum BDNF levels in patients with SLE.
  
  
  CONCLUSIONS
  Our data do not support the common variant Val66Met of the BDNF gene as an etiologic factor in the various forms of PS and serum BDNF levels in SLE.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. atsuko-i@med.uoeh-u.ac.jp
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ikenouchi-Sugita
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.forename: Taro
authors.initials: T
authors.lastname: Kishi
authors.forename: Wakako
authors.initials: W
authors.lastname: Umene-Nakano
authors.forename: Hikaru
authors.initials: H
authors.lastname: Hori
authors.forename: Asuka
authors.initials: A
authors.lastname: Katsuki
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Saito
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D019943:Amino Acid Substitution; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D010054:Brief Psychiatric Rating Scale; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006785:Hospitals, University; D006801:Humans; D007564:Japan; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000235:genetics* / Q000378:metabolism / Q000523:psychology; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor