title: Involvement of central noradrenaline, serotonin and dopamine system in the antidepressant activity of fruits of Solanum torvum (Solanaceae).
abstract: The methanolic extract (ME) of Solanum torvum seeds and its ethyl acetate fraction (EAF) were investigated for their antidepressant activity using behavioral (forced swim test, FST and tail suspension test, TST) and biochemical (monoamine oxidase, MAO reduced activity) tests. ME (10, 30 and 100 mg kg(-1)) and EAF (10 and 30 mg kg(-1)) dose dependently inhibited the immobility period, increased noradrenaline, serotonin and dopamine levels and inhibited the MAO enzymes in FST and TST using mice. Furthermore, we have observed antagonism between the threshold dose of ME (30 and 100 mg kg(-1)) and EAF (10 and 30 mg kg(-1)) with antagonists on behaviour mediated by neurotransmitters noradrenaline, serotonin and dopamine. MAO-A inhibition was more prominent as compared to MAO-B inhibition. The study provides evidence for antidepressant actions of S. torvum.
authors.affiliation: Department of Pharmacology , M.G.V College of Pharmacy, Nasik 03, Panchavati, Maharashtra, India.
authors.forename: Rehan
authors.initials: R
authors.lastname: Momin
authors.forename: Mahalaxmi
authors.initials: M
authors.lastname: Mohan
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry* / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy; D004298:Dopamine / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005638:Fruit / Q000737:chemistry*; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use; D012701:Serotonin / Q000378:metabolism*; D019657:Solanaceae / Q000737:chemistry*
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts; D012701:Serotonin; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine