title: The impact of Ly49-NK cell-dependent recognition of MCMV infection on innate and adaptive immune responses.
abstract: Clinical and experimental data indicate that a subset of innate lymphocytes, natural killer (NK) cells, plays a crucial role in the response against herpesviruses, especially cytomegaloviruses (CMV). Indeed, in mice, NK cells, due to the expression of germline encoded Ly49 receptors, possess multiple mechanisms to recognize CMV infection. Classically, this results in NK cell activation and the destruction of the infected cells. More recently, however, this unique host-pathogen interaction has permitted the discovery of novel aspects of NK cell biology, implicating them in the regulation of adaptive immune responses as well as in the development of immunological memory. Here, we will concisely review the newly acquired evidence pertaining to NK cell Ly49-dependent recognition of MCMV-infected cell and the ensuing NK cell regulatory responses.
authors.affiliation: Department of Human Genetics, McGill University, Montreal, QC, Canada H3G OB1.
authors.forename: Michal
authors.initials: M
authors.lastname: Pyzik
authors.forename: Eve-Marie
authors.initials: EM
authors.lastname: Gendron-Pontbriand
authors.forename: Silvia M
authors.initials: SM
authors.lastname: Vidal
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D055650:NK Cell Lectin-Like Receptor Subfamily A / Q000276:immunology* / Q000378:metabolism
chemical_list: D055650:NK Cell Lectin-Like Receptor Subfamily A