title: Quality of life and impulsivity in bipolar disorder.
abstract: OBJECTIVE
  Bipolar disorder (BD) is a chronic psychiatric illness that impairs quality of life (QoL) in numerous life domains even when mood symptoms are not present and is characterized by elevated impulsivity. Many of the comorbid conditions that are associated with diminished QoL in BD also involve impulsivity. The objective of this project was to investigate whether impulsivity might mediate the effects of these comorbid conditions on poor QoL.
  
  
  METHODS
  A total of 76 participants diagnosed with bipolar I disorder by the Structured Clinical Interview for DSM-IV Axis I disorders completed the Quality of Life in Bipolar Disorder (QoL-BD) scale, the Barratt Impulsivity Scale (BIS-11), and the Positive Urgency Measure (PUM). Participants were also assessed for comorbid DSM-IV diagnoses of anxiety, substance use, and impulse control disorders.
  
  
  RESULTS
  Several subscales of the BIS-11 as well as the PUM total score were significantly negatively correlated with overall QoL. PUM total score remained a significant predictor of QoL after controlling for comorbid anxiety, substance use, and impulse control disorders. After controlling for impulsivity, comorbid disorders were no longer significantly related to overall QoL.
  
  
  CONCLUSIONS
  The data support the hypothesis that impulsivity, specifically positive urgency, is highly correlated with QoL in BD. Impulsivity was found to mediate the relation between QoL and several comorbidities in BD. Interventions targeting impulsivity might help to improve QoL in BD.
authors.affiliation: Department of Psychology, University of British Columbia, Vancouver, BC, Canada. sevictor@psych.ubc.ca
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Victor
authors.forename: Sheri L
authors.initials: SL
authors.lastname: Johnson
authors.forename: Ian H
authors.initials: IH
authors.lastname: Gotlib
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000150:complications* / Q000523:psychology*; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life / Q000523:psychology*; D012189:Retrospective Studies; D055815:Young Adult