title: Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives.
abstract: A series of 6-aryl-5-cyano-2-thiouracil derivatives (1a-d) was synthesized by the reaction of ethyl cyanoacetate with thiourea and aldehydes. These products were used as intermediate compounds for the synthesis of a number of thiouracil derivatives (2a-d to 10a-d). All compounds were screened for antibacterial and antifungal activities. Some of the prepared compounds, 6-(4-fluorophenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (2a), 4-oxo-2-thioxo-6-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide (2d), 6-(4-fluorophenyl)-4-hydrazino-2-thioxo-1,2-dihydropyrimidine-5-cabonitrile (7a) and 4-hydrazino-2-thioxo-6-(3,4,5-trimethoxyphenyl)-1,2-dihydropyrimidine-5-carbonitrile (7d) revealed promising antimicrobial activity.
authors.affiliation: Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt. doctor-mosaad@hotmail.com
authors.forename: Mosaad Sayed
authors.initials: MS
authors.lastname: Mohamed
authors.forename: Samir Mohamed
authors.initials: SM
authors.lastname: Awad
authors.forename: Naglaa Mohamed
authors.initials: NM
authors.lastname: Ahmed
mesh_terms: D000085:Acetates / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D056449:Bacillales / Q000187:drug effects; D055598:Chemical Phenomena; D052978:Disk Diffusion Antimicrobial Tests; D015195:Drug Design; D004926:Escherichia coli / Q000187:drug effects; D007202:Indicators and Reagents / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000187:drug effects; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000737:chemistry; D044366:Transition Temperature; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000085:Acetates; D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007202:Indicators and Reagents; D009570:Nitriles; C056431:5-cyanouracil; D014498:Uracil; D013890:Thiourea; C007659:ethyl cyanoacetate