title: Multiple insecticide resistance in Aedes aegypti (Diptera: Culicidae) populations compromises the effectiveness of dengue vector control in French Guiana.
abstract: In French Guiana, pyrethroids and organophosphates have been used for many years against Aedes aegypti. We aimed to establish both the resistance level of Ae. aegypti and the ultra low volume spray efficacy to provide mosquito control services with practical information to implement vector control and resistance management. Resistance to deltamethrin and fenitrothion was observed. In addition, the profound loss of efficacy of AquaK'othrine® and the moderate loss of efficacy of Paluthion® 500 were recorded. Fenitrothion remained the most effective candidate for spatial application in French Guiana until its removal in December 2010. Further investigation of the mechanism of resistance to deltamethrin demonstrated the involvement of mixed-function oxidases and, to a lesser extent, of carboxylesterases. However, these observations alone cannot explain the level of insecticide resistance we observed during tube and cage tests.
authors.affiliation: Unité d'entomologie Médicale, Institut Pasteur de la Guyane, French Guiana. idusfour@pasteur-cayenne.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dusfour
authors.forename: Véronique
authors.initials: V
authors.lastname: Thalmensy
authors.forename: Pascal
authors.initials: P
authors.lastname: Gaborit
authors.forename: Jean
authors.initials: J
authors.lastname: Issaly
authors.forename: Romuald
authors.initials: R
authors.lastname: Carinci
authors.forename: Romain
authors.initials: R
authors.lastname: Girod
mesh_terms: D000330:Aedes / Q000201:enzymology; D000818:Animals; D003715:Dengue / Q000517:prevention & control; D005260:Female; D005616:French Guiana; D007305:Insecticide Resistance; D007306:Insecticides; D007928:Lethal Dose 50; D009032:Mosquito Control; D010755:Organophosphates; D011722:Pyrethrins
chemical_list: D007306:Insecticides; D010755:Organophosphates; D011722:Pyrethrins