title: Borage and fish oils lifelong supplementation decreases inflammation and improves bone health in a murine model of senile osteoporosis.
abstract: Fats are prevalent in western diets; they have known deleterious effects on muscle insulin resistance and may contribute to bone loss. However, relationships between fatty acids and locomotor system dysfunctions in elderly population remain controversial. The aim of this study was to analyze the impact of fatty acid quality on the age related evolution of the locomotor system and to understand which aging mechanisms are involved. In order to analyze age related complications, the SAMP8 mouse strain was chosen as a progeria model as compared to the SAMR1 control strain. Then, two months old mice were divided in different groups and subjected to the following diets : (1) standard "growth" diet - (2) "sunflower" diet (high ω6/ω3 ratio) - (3) "borage" diet (high γ-linolenic acid) - (4) "fish" diet (high in long chain ω3). Mice were fed ad libitum through the whole protocol. At 12 months old, the mice were sacrificed and tissues were harvested for bone studies, fat and muscle mass measures, inflammation parameters and bone cell marker expression. We demonstrated for the first time that borage and fish diets restored inflammation and bone parameters using an original model of senile osteoporosis that mimics clinical features of aging in humans. Therefore, our study strongly encourages nutritional approaches as relevant and promising strategies for preventing aged-related locomotor dysfunctions.
authors.affiliation: Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Wauquier
authors.forename: Valentin
authors.initials: V
authors.lastname: Barquissau
authors.forename: Laurent
authors.initials: L
authors.lastname: Léotoing
authors.forename: Marie-Jeanne
authors.initials: MJ
authors.lastname: Davicco
authors.forename: Patrice
authors.initials: P
authors.lastname: Lebecque
authors.forename: Sylvie
authors.initials: S
authors.lastname: Mercier
authors.forename: Claire
authors.initials: C
authors.lastname: Philippe
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Miot-Noirault
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Chardigny
authors.forename: Béatrice
authors.initials: B
authors.lastname: Morio
authors.forename: Yohann
authors.initials: Y
authors.lastname: Wittrant
authors.forename: Véronique
authors.initials: V
authors.lastname: Coxam
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D016723:Bone Remodeling / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology*; D029683:Borago / Q000737:chemistry*; D002113:Calcification, Physiologic / Q000187:drug effects; D004041:Dietary Fats / Q000032:analysis; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005260:Female; D005395:Fish Oils / Q000494:pharmacology / Q000627:therapeutic use*; D006262:Health; D006368:Helianthus; D007249:Inflammation / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D051379:Mice; D008817:Mice, Mutant Strains; D009929:Organ Size / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D010938:Plant Oils / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D004041:Dietary Fats; D005395:Fish Oils; D010938:Plant Oils