title: External validation of nomogram for the decline in serum anti-Müllerian hormone in women: a population study of 15,834 infertility patients.
abstract: The value of anti-müllerian hormone (AMH) as a marker of the ovarian reserve is becoming clear in a range of clinical contexts.This study reports the external validation of a quadratic model-based AMH–age nomogram using a cohort of 15,834 US women. All models previously investigated for the decline in ovarian reserve (i.e. linear, bi-linear, decay curve, power and quadratic models) tended to overestimate AMH by approximately 11% versus the published nomogram, indicating some between-population heterogeneity. Bootstrapping of 1000 datasets indicated that the quadratic model provided the best fit, confirming the choice of this model in the AMH–age nomogram. This nomogram can therefore be used with confidence for the interpretation of AMH in clinical populations.
authors.affiliation: Centre for Population and Health Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom. scott.nelson@glasgow.ac.uk
authors.forename: Scott M
authors.initials: SM
authors.lastname: Nelson
authors.forename: Martina C
authors.initials: MC
authors.lastname: Messow
authors.forename: Alex
authors.initials: A
authors.lastname: McConnachie
authors.forename: Hamish
authors.initials: H
authors.lastname: Wallace
authors.forename: Thomas
authors.initials: T
authors.lastname: Kelsey
authors.forename: R
authors.initials: R
authors.lastname: Fleming
authors.forename: R A
authors.initials: RA
authors.lastname: Anderson
authors.forename: B
authors.initials: B
authors.lastname: Leader
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007246:Infertility / Q000097:blood* / Q000628:therapy; D008875:Middle Aged; D049451:Nomograms; D010053:Ovary / Q000502:physiology; D012044:Regression Analysis; D015203:Reproducibility of Results; D012107:Research Design
chemical_list: D054304:Anti-Mullerian Hormone