title: Evolution of the mammalian lysozyme gene family.
abstract: BACKGROUND
  Lysozyme c (chicken-type lysozyme) has an important role in host defense, and has been extensively studied as a model in molecular biology, enzymology, protein chemistry, and crystallography. Traditionally, lysozyme c has been considered to be part of a small family that includes genes for two other proteins, lactalbumin, which is found only in mammals, and calcium-binding lysozyme, which is found in only a few species of birds and mammals. More recently, additional testes-expressed members of this family have been identified in human and mouse, suggesting that the mammalian lysozyme gene family is larger than previously known.
  
  
  RESULTS
  Here we characterize the extent and diversity of the lysozyme gene family in the genomes of phylogenetically diverse mammals, and show that this family contains at least eight different genes that likely duplicated prior to the diversification of extant mammals. These duplicated genes have largely been maintained, both in intron-exon structure and in genomic context, throughout mammalian evolution.
  
  
  CONCLUSIONS
  The mammalian lysozyme gene family is much larger than previously appreciated and consists of at least eight distinct genes scattered around the genome. Since the lysozyme c and lactalbumin proteins have acquired very different functions during evolution, it is likely that many of the other members of the lysozyme-like family will also have diverse and unexpected biological properties.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. david.irwin@utoronto.ca
authors.forename: David M
authors.initials: DM
authors.lastname: Irwin
authors.forename: Jason M
authors.initials: JM
authors.lastname: Biegel
authors.forename: Caro-Beth
authors.initials: CB
authors.lastname: Stewart
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005091:Exons; D005796:Genes; D006801:Humans; D007438:Introns; D008322:Mammals / Q000235:genetics*; D008969:Molecular Sequence Data; D009113:Muramidase / Q000235:genetics*; D010802:Phylogeny; D016415:Sequence Alignment
chemical_list: D009113:Muramidase