title: Blinded, controlled field trial of two commercially available Mycoplasma bovis bacterin vaccines in veal calves.
abstract: Mycoplasma bovis is an etiologic agent of pneumonia, arthritis, and otitis in young calves, such as those found in the special-fed veal industry. We conducted a blinded, controlled trial of two commercially available M. bovis bacterin vaccines for the prevention of respiratory disease in calves associated with M. bovis infection. Calves were randomly assigned to a subcutaneous treatment of vaccine A (n=50), adjuvant A (n=50), vaccine B (n=50), or 0.9% sterile saline solution (n=50) beginning at 27 days of age. Upper-respiratory tract colonization was not impacted by vaccination status. Vaccine A significantly reduced the presence of lung lesions (p=0.0325), however there was no significant reduction of M. bovis in lung lesions. Vaccine B did not significantly reduce total lung lesions or M. bovis-specific lung lesions. The relative risk was determined to be 0.56, 1.0, and 1.36 for vaccine A, adjuvant A, and vaccine B, respectively. There was no association between the total specific antibody isotype (IgM, IgG1, IgG2, IgA) concentrations or M. bovis antibodies and the M. bovis-associated morbidity in the veal calves. Under the field conditions of this study, observed vaccine efficacy for vaccine A and vaccine B was 44% and less than 1%, respectively.
authors.affiliation: The Pennsylvania State University, Department of Veterinary & Biomedical Sciences, University Park, PA 16802, USA.
authors.forename: Marty K
authors.initials: MK
authors.lastname: Soehnlen
authors.forename: Adnan
authors.initials: A
authors.lastname: Aydin
authors.forename: Eugene J
authors.initials: EJ
authors.lastname: Lengerich
authors.forename: Beth A
authors.initials: BA
authors.lastname: Houser
authors.forename: Ginger D
authors.initials: GD
authors.lastname: Fenton
authors.forename: Hannah R
authors.initials: HR
authors.lastname: Lysczek
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Burns
authors.forename: Louise I
authors.initials: LI
authors.lastname: Byler
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Hattel
authors.forename: David R
authors.initials: DR
authors.lastname: Wolfgang
authors.forename: Bhushan M
authors.initials: BM
authors.lastname: Jayarao
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007279:Injections, Subcutaneous; D008168:Lung / Q000382:microbiology / Q000473:pathology; D009175:Mycoplasma Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D045682:Mycoplasma bovis / Q000276:immunology*; D012140:Respiratory Tract Diseases / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M