title: Hyalinizing clear cell carcinoma: a case report and review of the literature.
abstract: Hyalinizing clear cell carcinoma (HCCC) is a low-grade malignancy with infiltrative growth pattern. It affects mainly the minor salivary glands of adult women. The most frequent locations of this tumor are the palate and tongue. HCCC shows a poorly circumscribed, infiltrative, and essentially monomorphic population of clear cells with few mitoses and almost no nuclear or cellular pleomorphism. These cells form trabeculae, cords, islands, and/or nests, circumscribed by variable amounts of hyalinized fibrous bands with foci of myxohyaline stroma. S-100 protein, muscle-specific actin, smooth muscle actin, myosin, and calponin are consistently negative, which strongly indicates the absence of myoepithelial cell differentiation in this tumor. We present a case of HCCC affecting the upper vestibule in a 53-year-old man. The patient was treated by surgery and postoperative radiation and did not show recurrence or distant metastases 3 years after treatment. Discussed also are the clinical and pathologic features of this tumor along with the differential diagnosis and a literature review.
authors.affiliation: Faculty of Dentistry, Université de Montréal, Montréal, Canada. adel.kauzman@umontreal.ca
authors.forename: Adel
authors.initials: A
authors.lastname: Kauzman
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Tabet
authors.forename: Tudor-Ioan
authors.initials: TI
authors.lastname: Stiharu
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis*; D001706:Biopsy; D003238:Connective Tissue / Q000473:pathology; D003593:Cytoplasm / Q000648:ultrastructure; D004847:Epithelial Cells / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D006818:Hyalin; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000175:diagnosis*; D012470:Salivary Glands, Minor / Q000473:pathology*
chemical_list: D007633:Keratins