title: Synthesis of long DNA-based nanowires.
abstract: Here we describe novel procedures for production of DNA-based nanowires. This include synthesis and characterization of the one-to-one double-helical complex of poly(dG)-poly(dC), triple-helical poly(dG)-poly(dG)-poly(dC) and G4-DNA, which is a quadruple-helical form of DNA. All these types of DNA-based molecules were synthesized enzymatically using Klenow exo(-) fragment of DNA Polymerase I. All the above types of nanowires are characterized by a narrow-size distribution of molecules. The contour length of the molecules can be varied from tens to hundreds of nanometers. These structures possess improved conductive and mechanical properties with respect to a canonical random-sequenced DNA and can possibly be used as wire-like conducting or semiconducting nanostructures in the field of nanoelectronics.
authors.affiliation: Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel. s2shak@post.tau.ac.il
authors.forename: Alexander
authors.initials: A
authors.lastname: Kotlyar
mesh_terms: D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D004256:DNA Polymerase I / Q000737:chemistry / Q000378:metabolism; D004553:Electric Conductivity; D054856:G-Quadruplexes; D036103:Nanotechnology / Q000379:methods*; D053770:Nanowires / Q000737:chemistry*; D011089:Polydeoxyribonucleotides / Q000737:chemistry
chemical_list: D011089:Polydeoxyribonucleotides; C016681:poly(dG).poly(dC); D004247:DNA; D004256:DNA Polymerase I