title: Relationship of maternal vitamin D level with maternal and infant respiratory disease.
abstract: OBJECTIVE
  The objective of the study was to investigate the association of maternal vitamin D and maternal asthma and infant respiratory infection severity.
  
  
  METHODS
  The study included cross-sectional analyses of 340 mother-infant dyads enrolled from September to May 2004-2008 during an infant viral respiratory infection. Maternal vitamin D levels were determined from enrollment blood specimens. At enrollment, we determined self-reported maternal asthma and infant respiratory infection severity using a bronchiolitis score. We assessed the association of maternal vitamin D levels and maternal asthma and infant bronchiolitis score in race-stratified multivariable regression models.
  
  
  RESULTS
  The cohort was 70% white, 19% African American, and 21% had asthma. Overall, the median maternal vitamin D level was 20 ng/mL (interquartile range, 14-28). Among white women, a 14 ng/mL increase in vitamin D was associated with a decreased odds of asthma (adjusted odds ratio, 0.54; 95% confidence interval, 0.33-0.86). Maternal vitamin D was not associated with infant bronchiolitis score.
  
  
  CONCLUSIONS
  Higher maternal vitamin D levels were associated with decreased odds of asthma.
authors.affiliation: Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Kecia N
authors.initials: KN
authors.lastname: Carroll
authors.forename: Tebeb
authors.initials: T
authors.lastname: Gebretsadik
authors.forename: Emma K
authors.initials: EK
authors.lastname: Larkin
authors.forename: William D
authors.initials: WD
authors.lastname: Dupont
authors.forename: Zhouwen
authors.initials: Z
authors.lastname: Liu
authors.forename: Sara
authors.initials: S
authors.lastname: Van Driest
authors.forename: Tina V
authors.initials: TV
authors.lastname: Hartert
mesh_terms: D000328:Adult; D001741:Black or African American; D001249:Asthma / Q000097:blood*; D001988:Bronchiolitis / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D044465:White People
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D