title: Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial.
abstract: It has been shown that topical linoleic acid rich-phosphatidylcholine seems to be effective in normalization of follicular hyperkeratinization, whereas nicotinamide has an interesting anti-inflammatory effect. However, little is known about their combined effect on acne. A multicentre, double-blind, 12-week randomized vehicle and parallel-active control study was conducted by clinical and biophysical non-invasive measurements to evaluate the efficacy, tolerability and safety of a 4% nicotinamide-phospholipidic (N-PHCL) emulsion vs. 1% topical clindamycin phosphate applied once daily. Four percentage N-PHCL cosmetic treatment resulted slightly superior to topical clindamycin with all the parameters studied for its better compliance and the global clinical improvement.
authors.affiliation: Applied Cosmetic Dermatology, II University of Naples, Italy. info@mavicosmetics.it
authors.forename: P
authors.initials: P
authors.lastname: Morganti
authors.forename: E
authors.initials: E
authors.lastname: Berardesca
authors.forename: B
authors.initials: B
authors.lastname: Guarneri
authors.forename: F
authors.initials: F
authors.lastname: Guarneri
authors.forename: G
authors.initials: G
authors.lastname: Fabrizi
authors.forename: P
authors.initials: P
authors.lastname: Palombo
authors.forename: M
authors.initials: M
authors.lastname: Palombo
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D019787:Linoleic Acid / Q000737:chemistry*; D009536:Niacinamide / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D010713:Phosphatidylcholines; D009536:Niacinamide; D002981:Clindamycin; D019787:Linoleic Acid