title: Biosensors and their applications in microbial metabolic engineering.
abstract: Many metabolic pathways in microbial hosts have been created, modified and engineered to produce useful molecules. The titer and yield of a final compound is often limited by the inefficient use of cellular resources and imbalanced metabolism. Engineering sensory-regulation devices that regulate pathway gene expression in response to the environment and metabolic status of the cell have great potential to solve these problems, and enhance product titers and yields. This review will focus on recent developments in biosensor design, and their applications for controlling microbial behavior.
authors.affiliation: Joint BioEnergy Institute, 5885 Hollis Street, Emeryville, CA 94608, USA.
authors.forename: Fuzhong
authors.initials: F
authors.lastname: Zhang
authors.forename: Jay
authors.initials: J
authors.lastname: Keasling
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D015374:Biosensing Techniques / Q000145:classification / Q000379:methods*; D002633:Chemotaxis; D004784:Environmental Monitoring / Q000379:methods; D015964:Gene Expression Regulation, Bacterial; D005818:Genetic Engineering; D053858:Metabolic Networks and Pathways; D008828:Microbiological Techniques; D009994:Osmolar Concentration; D010100:Oxygen / Q000378:metabolism; D033902:Periplasmic Binding Proteins / Q000378:metabolism; D011401:Promoter Regions, Genetic; D013696:Temperature; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D033902:Periplasmic Binding Proteins; D014157:Transcription Factors; D010100:Oxygen