title: Novel botanical drug for the treatment of diabetic neuropathy.
abstract: Diabetic neuropathy has multiple aspects of pathophysiology including metabolic derangements and alterations of microvessel with hyperglycemia. Currently, there is no effective long-term treatment based on the pathologic mechanisms. Nerve regeneration with nerve growth factor (NGF) has been on clinical trials as a treatment option. This article reviews an action of a herbal medicine, DA 9801, whose mechanism of action is related to NGF in treating diabetic neuropathy.
authors.affiliation: Research Center of Dong-A Pharm Co., Ltd, Yongin 446-905, Korea.
authors.forename: Sang-Zin
authors.initials: SZ
authors.lastname: Choi
authors.forename: Mi-Won
authors.initials: MW
authors.lastname: Son
mesh_terms: D000818:Animals; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000503:physiopathology; D027742:Dioscorea / Q000737:chemistry; D015507:Drugs, Investigational / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D020932:Nerve Growth Factor / Q000494:pharmacology; D009416:Nerve Regeneration / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D028321:Plant Preparations / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: C562027:DA-9801; D015507:Drugs, Investigational; D010936:Plant Extracts; D028321:Plant Preparations; D020932:Nerve Growth Factor