title: [Eosinophilic esophagitis--the experience in a tertiary pediatric center].
abstract: BACKGROUND
  Eosinophilic esophagitis (EoE) is an inflammatory disorder with increasing prevalence. It typically presents with swallowing difficulties, heartburn or dyspepsia, and in toddlers, failure to thrive. EoE is characterized by eosinophilic infiltrates of the esophageal mucosa, and endoscopies with tissue diagnosis are mandatory. Hypersensitivity has been implicated in the pathogenesis, therefore, most treatment options include steroids and allergen avoidance.
  
  
  OBJECTIVE
  To summarize a tertiary pediatric clinic's experience with EoE in children and adolescents, describe the spectrum of clinical presentations and treatment options, and raise awareness of this disorder among medical personnel.
  
  
  METHODS
  A retrospective, descriptive study of patients diagnosed with EoE at our institute over the past 5 years. Demographic details, presenting symptoms, laboratory studies, endoscopic and pathologic findings were analyzed. Information regarding medical and nutritional therapies and response to treatment were summarized.
  
  
  RESULTS
  Fifteen cases of EoE in children and adolescents are described. Average age at diagnosis was 9 years (range 0.7-161. The most common complaint was dysphagia (60%e. The majority demonstrated food allergies 19/121. Most of the patients were treated with topical ingested steroids, while others had either elemental formula or allergen elimination. Favorable responses were seen in most patients treated with steroids (8/11). Long-term results of nutritional therapy are insufficient to draw conclusions on its efficacy.
  
  
  CONCLUSIONS
  EoE causes major eating difficulties and affects quality of life in children, sometimes accompanied by failure to thrive. There is a clear association with food allergies, and positive responses to steroids are common. A high index of suspicion and referral to a gastroenterologist for definite diagnosis are required. Combining medical with nutritional treatment seems promising but further studies regarding the long-term outcome are needed.
authors.affiliation: anatguz@gmail.com
authors.forename: Anat
authors.initials: A
authors.lastname: Guz-Mark
authors.forename: Noam
authors.initials: N
authors.lastname: Zevit
authors.forename: Yoram
authors.initials: Y
authors.lastname: Rosenbach
authors.forename: Sara
authors.initials: S
authors.lastname: Morgenstern
authors.forename: Dana
authors.initials: D
authors.lastname: Reznik
authors.forename: Keren
authors.initials: K
authors.lastname: Davidson
authors.forename: Raanan
authors.initials: R
authors.lastname: Shamir
authors.forename: Gilat
authors.initials: G
authors.lastname: Livni
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003680:Deglutition Disorders / Q000175:diagnosis / Q000209:etiology*; D057765:Eosinophilic Esophagitis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D005512:Food Hypersensitivity / Q000150:complications* / Q000175:diagnosis; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D011788:Quality of Life; D012189:Retrospective Studies
chemical_list: D005938:Glucocorticoids