title: 23. Pain in patients with cancer.
abstract: Pain in patients with cancer can be refractory to pharmacological treatment or intolerable side effects of pharmacological treatment may seriously disturb patients' quality of life. Specific interventional pain management techniques can be an effective alternative for those patients. The appropriate application of these interventional techniques provides better pain control, allows the reduction of analgesics and hence improves quality of life. Until recently, the majority of these techniques are considered to be a fourth consecutive step following the World Health Organization's pain treatment ladder. However, in cancer patients, earlier application of interventional pain management techniques can be recommended even before considering the use of strong opioids. Epidural and intrathecal medication administration allow the reduction of the daily oral or transdermal opioid dose, while maintaining or even improving the pain relief and reducing the side effects. Cervical cordotomy may be considered for patients suffering with unilateral pain at the level below the dermatome C5. This technique should only be applied in patients with a life expectancy of less than 1 year. Plexus coeliacus block or nervus splanchnicus block are recommended for the management of upper abdominal pain due to cancer. Pelvic pain due to cancer can be managed with plexus hypogastricus block and the saddle or lower end block may be a last resort for patients suffering with perineal pain. Back pain due to vertebral compression fractures with or without pathological tumor invasion may be managed with percutaneous vertebroplasty or kyphoplasty. All these interventional techniques should be a part of multidisciplinary patient program.
authors.affiliation: Department of Anesthesiology Pain Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. k.vissers@anes.umcn.nl
authors.forename: Kris C P
authors.initials: KC
authors.lastname: Vissers
authors.forename: Kees
authors.initials: K
authors.lastname: Besse
authors.forename: Michel
authors.initials: M
authors.lastname: Wagemans
authors.forename: Wouter
authors.initials: W
authors.lastname: Zuurmond
authors.forename: Maurice J M M
authors.initials: MJ
authors.lastname: Giezeman
authors.forename: Arno
authors.initials: A
authors.lastname: Lataster
authors.forename: Nagy
authors.initials: N
authors.lastname: Mekhail
authors.forename: Allen W
authors.initials: AW
authors.lastname: Burton
authors.forename: Maarten
authors.initials: M
authors.lastname: van Kleef
authors.forename: Frank
authors.initials: F
authors.lastname: Huygen
mesh_terms: D015746:Abdominal Pain / Q000188:drug therapy / Q000209:etiology / Q000628:therapy; D000465:Algorithms; D015360:Analgesia, Epidural; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D059350:Chronic Pain / Q000175:diagnosis / Q000209:etiology*; D002818:Cordotomy; D019317:Evidence-Based Medicine; D006801:Humans; D007278:Injections, Spinal; D009369:Neoplasms / Q000150:complications*; D009407:Nerve Block; D059408:Pain Management / Q000379:methods*; D010386:Pelvic Neoplasms / Q000150:complications; D010502:Perineum / Q000502:physiology; D013122:Spinal Diseases / Q000150:complications; D013727:Terminal Care; D059265:Visceral Pain / Q000209:etiology / Q000628:therapy
chemical_list: D000700:Analgesics