title: Disseminated intravascular coagulation as the presenting sign of gastric cancer during pregnancy.
abstract: Gastric cancer during pregnancy is rare and the outcome is generally poor. A 36-year-old woman in the 28th week of gestation was complicated with disseminated intravascular coagulation (DIC), and she was diagnosed with gastric cancer with bone marrow metastasis. Cesarean delivery followed by sequential methotrexate (100 mg/m2) and 5-fluorouracil (600 mg/m2) chemotherapy was conducted. DIC was successfully managed with blood transfusion and chemotherapy. She has received chemotherapy in the outpatient clinic. This report is the second case of a pregnant woman with DIC as the initial manifestation of advanced gastric cancer. Prompt diagnosis and chemotherapy increases the chances of a relatively favorable outcome even in advanced gastric cancer presenting with DIC due to bone marrow involvement.
authors.affiliation: Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takai
authors.forename: Eiji
authors.initials: E
authors.lastname: Kondoh
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Sato
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Kakui
authors.forename: Keiji
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Konishi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019046:Bone Marrow Neoplasms / Q000188:drug therapy / Q000556:secondary*; D018279:Carcinoma, Signet Ring Cell / Q000556:secondary*; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy / Q000473:pathology*; D013274:Stomach Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
chemical_list: D005472:Fluorouracil; D008727:Methotrexate