title: Evaluation of a new polysulfone hemofilter for continuous renal replacement therapy.
abstract: New strategies using continuous renal replacement therapy as a tool to achieve immunomodulation in septic acute kidney injury have been proposed. The hypothesis is based on the possibility to remove inflammatory mediators and oxidants in a wide spectrum of molecular weights, thanks to new, highly permeable synthetic membranes. A new polysulfone hemofilter with high permeability and a sharp high cut-off membrane (CUREFLO™; Asahi Kasei Kuraray Medical Co., Ltd., Tokyo, Japan) has been evaluated in this study to assess IL-6 and advanced oxidation protein product removal in critically ill patients undergoing continuous renal replacement therapy. Unit performance, sieving coefficients and clearances were evaluated in fourteen patients undergoing continuous veno-venous hemofiltration and continuous veno-venous hemodialysis.
authors.affiliation: Department of Nephrology San Bortolo Hospital and International Renal Research Institute Vicenza, Vicenza, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Floris
authors.forename: Nicola
authors.initials: N
authors.lastname: Marchionna
authors.forename: Anna
authors.initials: A
authors.lastname: Clementi
authors.forename: Jeong Chul
authors.initials: JC
authors.lastname: Kim
authors.forename: Dinna N
authors.initials: DN
authors.lastname: Cruz
authors.forename: Federico
authors.initials: F
authors.lastname: Nalesso
authors.forename: Monica
authors.initials: M
authors.lastname: Zanella
authors.forename: Francesco
authors.initials: F
authors.lastname: Garzotto
authors.forename: Massimo
authors.initials: M
authors.lastname: de Cal
authors.forename: Grazia Maria
authors.initials: GM
authors.lastname: Virzì
authors.forename: Alessandra
authors.initials: A
authors.lastname: Brendolan
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*; D000327:Adsorption; D003404:Creatinine / Q000097:blood; D006439:Hemodynamics; D006440:Hemofiltration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007700:Kinetics; D008567:Membranes, Artificial; D008875:Middle Aged; D010084:Oxidation-Reduction; D010539:Permeability; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D011446:Prospective Studies; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods*; D013450:Sulfones / Q000737:chemistry / Q000378:metabolism; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000032:analysis / Q000097:blood; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D015850:Interleukin-6; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D001613:beta 2-Microglobulin; C017662:polysulfone P 1700; D014527:Uric Acid; D014508:Urea; D003404:Creatinine