title: Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia.
abstract: A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related immune dysregulation in an immunocompromised host.
authors.affiliation: Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, the Netherlands.
authors.forename: Annick A J M
authors.initials: AA
authors.lastname: van de Ven
authors.forename: Jan Willem
authors.initials: JW
authors.lastname: Douma
authors.forename: Carin
authors.initials: C
authors.lastname: Rademaker
authors.forename: Anton M
authors.initials: AM
authors.lastname: van Loon
authors.forename: Annemarie M J
authors.initials: AM
authors.lastname: Wensing
authors.forename: Jaap-Jan
authors.initials: JJ
authors.lastname: Boelens
authors.forename: Elisabeth A M
authors.initials: EA
authors.lastname: Sanders
authors.forename: Joris M
authors.initials: JM
authors.lastname: van Montfrans
mesh_terms: D000293:Adolescent; D000361:Agammaglobulinemia / Q000150:complications*; D000998:Antiviral Agents / Q000494:pharmacology*; D017250:Caliciviridae Infections / Q000150:complications / Q000821:virology; D002908:Chronic Disease; D024882:Drug Resistance, Viral; D005243:Feces / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D029322:Norovirus / Q000302:isolation & purification; D010069:Oxadiazoles / Q000494:pharmacology*; D010080:Oxazoles; D030061:Parechovirus / Q000187:drug effects* / Q000302:isolation & purification; D010850:Picornaviridae Infections / Q000821:virology*; D011504:Protein-Losing Enteropathies / Q000821:virology*
chemical_list: D000998:Antiviral Agents; D010069:Oxadiazoles; D010080:Oxazoles; C115201:pleconaril