title: Pathophysiological roles of NADPH oxidase/nox family proteins in the vascular system. -Review and perspective-.
abstract: It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan. agou@intmed2.med.kyushu-u.ac.jp
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ago
authors.forename: Junya
authors.initials: J
authors.lastname: Kuroda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kamouchi
authors.forename: Junichi
authors.initials: J
authors.lastname: Sadoshima
authors.forename: Takanari
authors.initials: T
authors.lastname: Kitazono
mesh_terms: D001808:Blood Vessels / Q000201:enzymology*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D019255:NADPH Oxidases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014652:Vascular Diseases / Q000201:enzymology*
chemical_list: D017382:Reactive Oxygen Species; D019255:NADPH Oxidases