title: Molecular epidemiology of mumps virus strains circulating in south-west China from 2007 to 2009.
abstract: The genetic characteristics of mumps virus (MuV) strains isolated from sporadic mumps cases between 2007 and 2009 in three provinces of south-west China were investigated. MuV detection was carried out by nested RT-PCR on 117 cases. The small hydrophobic gene of 33 isolated strains was identified, and sequence analysis revealed that all the isolates belonged to the lineage genotype F with slight nucleotide variation. Furthermore, the virus haemagglutinin-neuraminidase and nucleoprotein antigens exhibited a high degree of nucleotide and amino acid similarity (>99 %) within all isolates, whilst the fusion protein appeared to have certain geographical differences. This study on molecular surveillance will help to monitor the circulation of MuV in China.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, PR China.
authors.forename: Haijing
authors.initials: H
authors.lastname: Shi
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, PR China.
authors.forename: Longding
authors.initials: L
authors.lastname: Liu
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, PR China.
authors.forename: Shaohui
authors.initials: S
authors.lastname: Ma
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, PR China.
authors.forename: Junying
authors.initials: J
authors.lastname: Chen
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, PR China.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Che
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, PR China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, PR China.
authors.forename: Qihan
authors.initials: Q
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D009107:Mumps / Q000453:epidemiology* / Q000821:virology*; D009109:Mumps virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D058974:Phylogeography; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics; D055815:Young Adult
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins