title: Uptake dynamics of scrapie agent in the intestinal villous epithelium of suckling and weanling Syrian hamsters.
abstract: In mice, the number of intestinal villous columnar epithelium cells that incorporate abnormal prion protein (PrP(Sc) ) decreases significantly after weaning. In this study, the dynamics of PrP(Sc) uptake during the growth of hamsters were investigated by inoculating scrapie 263K agent orally into suckling and weanling Syrian hamsters and estimating the number of PrP(Sc) -positive villous epithelium cells immunohistochemically. The number of PrP(Sc) -positive cells declined significantly as the hamsters aged. The present results suggest that a tendency toward decline of PrP(Sc) -positive cells with increasing age might be a common phenomenon among the superfamily Muridae.
authors.affiliation: Laboratory of Biomedical Science, Department of Veterinary Medicine, College of Biosource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan. gr16510t@st.brs.nihon-u.ac.jp
authors.forename: Jyuri
authors.initials: J
authors.lastname: Kono
authors.forename: Ryoko
authors.initials: R
authors.lastname: Toyoshima
authors.forename: Tomoko
authors.initials: T
authors.lastname: Iseki
authors.forename: Yukita
authors.initials: Y
authors.lastname: Sato
authors.forename: Atushi
authors.initials: A
authors.lastname: Umematu
authors.forename: Misuzu
authors.initials: M
authors.lastname: Okano
authors.forename: Akiko
authors.initials: A
authors.lastname: Tashiro
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Ano
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Sata
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Onodera
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yukawa
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D006224:Cricetinae; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008647:Mesocricetus; D051379:Mice; D018620:PrPSc Proteins / Q000378:metabolism*
chemical_list: D018620:PrPSc Proteins