title: Atherosclerosis in psoriatic arthritis.
abstract: The atherosclerotic process is accelerated in several autoimmune rheumatic diseases. Effector cells of innate and adaptive immunity along with pro-inflammatory cytokines and other immune mediators are found in atherosclerotic lesions, where they play an important role in induction, progression and rupture of plaques. Psoriatic arthritis (PsA) is a chronic inflammatory disease, characterized by arthritis, enthesitis, dactilytis, osteitis, and axial involvement, along with skin manifestations. PsA is frequently associated with obesity, diabetes, dyslipidemia, hypertension, accelerated atherosclerosis and with increased cardiovascular morbidity and mortality. Disease-specific and traditional risk factors seem to account for the atherosclerotic burden in PsA patients. Some immunological factors which are involved in PsA can also contribute to atherosclerosis including C reactive protein (CRP), TNF-α, IFN-γ, IL-1, Il 6, IL23, and Th17.
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Ramonda
authors.forename: A
authors.initials: A
authors.lastname: Lo Nigro
authors.forename: V
authors.initials: V
authors.lastname: Modesti
authors.forename: L
authors.initials: L
authors.lastname: Nalotto
authors.forename: E
authors.initials: E
authors.lastname: Musacchio
authors.forename: L
authors.initials: L
authors.lastname: Iaccarino
authors.forename: L
authors.initials: L
authors.lastname: Punzi
authors.forename: A
authors.initials: A
authors.lastname: Doria
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000150:complications* / Q000276:immunology; D050197:Atherosclerosis / Q000150:complications* / Q000276:immunology; D002318:Cardiovascular Diseases / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D007155:Immunologic Factors; D007249:Inflammation / Q000150:complications / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D007155:Immunologic Factors