title: Impaired functional and hemodynamic response to graded exercise testing and its recovery in patients with subclinical hyperthyroidism.
abstract: OBJECTIVE
  To evaluate the functional and hemodynamic responses during exercise and its recovery in patients with subclinical hyperthyroidism (SCH).
  
  
  METHODS
  A cross-sectional study was carried out with 29 patients on TSH-suppressive therapy with levothyroxine for thyroid carcinoma and 35 euthyroid subjects. All volunteers underwent a cardiopulmonary exercise testing on a treadmill and functional and hemodynamic variables were measured during exercise and its recovery.
  
  
  RESULTS
  SCH patients showed impaired functional response to exercise, marked by lower values for oxygen consumption and exercise duration in addition to premature achievement of the anaerobic threshold. Heart-rate and blood pressure recovery immediately after exercise were slower among SCH patients when compared to euthyroid subjects.
  
  
  CONCLUSIONS
  SCH is associated with impaired functional and hemodynamic responses during exercise and its recovery.
authors.affiliation: Laboratório de Fisiologia do Exercício, Escola de Educação Física e Desportos, Universidade Federal do Rio de Janeiro, RJ, Brazil. patriciavigario@yahoo.com.br
authors.forename: Patrícia dos Santos
authors.initials: Pdos S
authors.lastname: Vigário
authors.forename: Dhiãnah Santini de Oliveira
authors.initials: DS
authors.lastname: Chachamovitz
authors.forename: Patrícia de Fátima dos Santos
authors.initials: Pde F
authors.lastname: Teixeira
authors.forename: Mauro Augusto dos
authors.initials: MA
authors.lastname: Santos
authors.forename: Fátima Palha de
authors.initials: FP
authors.lastname: Oliveira
authors.forename: Mário
authors.initials: M
authors.lastname: Vaisman
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D002277:Carcinoma / Q000188:drug therapy / Q000503:physiopathology; D004812:Epidemiologic Methods; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D013972:Thyrotropin / Q000627:therapeutic use; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013972:Thyrotropin; D013974:Thyroxine