title: Modeling follicle stimulating hormone levels in serum for controlled ovarian hyperstimulation I: comparing gonadotropin products.
abstract: BACKGROUND
  Despite the dangers of gonadotropin administration, our understanding of serum levels of gonadotropins in our patients is poor. We created a mathematical model of gonadotropin administration in order to learn about the temporal profiles of Follicle Stimulating Hormone (FSH) levels in patients related to the doses of different gonadotropin products administered.
  
  
  METHODS
  Model parameters for each product were determined from published pharmacokinetic information available from the manufacturers.
  
  
  RESULTS
  For each product, serum levels of FSH rose then fell following a single injection of FSH. When a gonadotropin dose was injected repeatedly (daily), each injection resulted in a peak level of FSH that was higher than the level attained from the previous injection. Daily FSH peaks rose asymptotically, requiring 3-10 days to approach the maximum. The maximum averaged 3.5 times the peak of the first injection. Decline of FSH following the final injection required 3-10 days to approach the baseline. Time courses and peak values of FSH using different gonadotropin preparations varied widely.
  
  
  CONCLUSIONS
  Knowledge of the slow changes of FSH that occur during modeled FSH administration will provide a framework for understanding the gonadotropin profiles that occur in patients during controlled ovarian hyperstimulation.
authors.affiliation: University Reproductive Associates, 214 Terrace Avenue, Hasbrouck Heights, NJ, USA. dhmcculloh@gmail.com.
authors.forename: David H
authors.initials: DH
authors.lastname: McCulloh
authors.forename: Priya
authors.initials: P
authors.lastname: Maseelall
authors.forename: Jose M
authors.initials: JM
authors.lastname: Colon
authors.forename: Peter G
authors.initials: PG
authors.lastname: McGovern
mesh_terms: D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006062:Gonadotropins / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D008954:Models, Biological; D010062:Ovulation Induction / Q000379:methods*
chemical_list: D006062:Gonadotropins; D005640:Follicle Stimulating Hormone