title: The effects of colloid pre-loading on thromboelastography prior to caesarean delivery: hydroxyethyl starch 130/0.4 versus succinylated gelatine.
abstract: This prospective, randomized, double-blind study compared the effects on thromboelastography (TEG) of pre-loading with two different colloid fluids prior to spinal anaesthesia for caesarean section. Healthy full-term parturients received either 500 ml 6% hydroxyethyl starch 130/0.4 (HES, n = 25) or 500 ml 4% succinylated gelatine (GEL, n = 25) prior to spinal anaesthesia. TEG parameters including reaction time (r-time), clot formation time (k-time), clot formation rate (α-angle) and maximum amplitude (MA) were measured immediately before and after pre-loading. Both groups had significantly shorter r-time and lower MA after pre-loading. The α-angle was significantly decreased after pre-loading with HES but not with GEL. No significant differences in k-time were induced pre-loading. In conclusion, pre-loading with HES or GEL was associated with a mild hypocoagulable effect in healthy parturients presenting for elective caesarean section; however, all TEG parameters in both groups remained within or very close to the normal range after pre-loading.
authors.affiliation: Department of Anaesthesiology, Uludag University Medical Faculty, 16059 Bursa, Turkey. ygturker@gmail.com
authors.forename: G
authors.initials: G
authors.lastname: Turker
authors.forename: T
authors.initials: T
authors.lastname: Yilmazlar
authors.forename: E Basagan
authors.initials: EB
authors.lastname: Mogol
authors.forename: A
authors.initials: A
authors.lastname: Gurbet
authors.forename: S
authors.initials: S
authors.lastname: Dizman
authors.forename: H
authors.initials: H
authors.lastname: Gunay
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D001780:Blood Coagulation Tests; D002585:Cesarean Section / Q000009:adverse effects*; D003102:Colloids / Q000008:administration & dosage; D005260:Female; D005780:Gelatin / Q000008:administration & dosage*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage; D010952:Plasma Substitutes / Q000008:administration & dosage; D011247:Pregnancy; D011446:Prospective Studies; D013386:Succinates / Q000008:administration & dosage*; D013916:Thrombelastography
chemical_list: D003102:Colloids; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D013386:Succinates; C060085:succinylated gelatin; D005780:Gelatin