title: Is there differences in cognitive and motor functioning between hemodialysis and peritoneal dialysis patients?
abstract: OBJECTIVE
  Change in cognitive function is one of the well-known consequences of the end-stage renal disease (ESRD). The aim of this study was to determine the effect of hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) on cognitive and motor functions.
  
  
  METHODS
  In this cross-sectional study, cognitive and motor functions were investigated in a selected population of 42 patients with ESRD (22 patients on chronic HD and 20 patients on CAPD, aged 50.31 ± 11.07 years). Assessment of cognitive and motor functions was performed by Symbol Digit Modalities Test (SDMT) and Complex Reactiometer Drenovac (CRD-series), a battery of computer-generated psychological tests to measure simple visual discrimination of signal location, short-term memory, simple convergent visual orientation, and convergent thinking.
  
  
  RESULTS
  The statistically significant difference in cognitive-motor functions between HD and CAPD patients was not found in any of the time-related parameters in all CRD-series tests or SDMT score. Higher serum levels of albumin, creatinine, and calcium were correlated with better cognitive-motor performance among all patients regardless of dialysis modality. The significant correlation between ultrafiltration rate per HD and short-term memory actualization test score (CRD-324 MT) among HD patients was found (r = 0.434, p = 0.025).
  
  
  CONCLUSIONS
  This study has demonstrated that well-nourished and medically stable HD and CAPD patients without clinical signs of dementia or cognitive impairment and without significant difference in age and level of education performed all tests of cognitive-motor abilities without statistically significant difference.
authors.affiliation: Department of Nephrology, University Hospital Split, Split, Croatia.
authors.forename: Josipa
authors.initials: J
authors.lastname: Radić
authors.forename: Dragan
authors.initials: D
authors.lastname: Ljutić
authors.forename: Mislav
authors.initials: M
authors.lastname: Radić
authors.forename: Vedran
authors.initials: V
authors.lastname: Kovačić
authors.forename: Milenka
authors.initials: M
authors.lastname: Sain
authors.forename: Katarina
authors.initials: K
authors.lastname: Dodig-Ćurković
mesh_terms: D003071:Cognition / Q000502:physiology*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010530:Peritoneal Dialysis; D011379:Prognosis; D011594:Psychometrics; D006435:Renal Dialysis; D012307:Risk Factors