title: ¹⁸F-FDG-PET/CT for detection of extramedullary acute myeloid leukemia.
abstract: Myeloid sarcoma in acute myeloid leukemia has been clearly defined by the World Health Organization but studies regarding the prevalence and the prognostic impact of extramedullary acute myeloid leukemia have not been conducted. We performed (18)Fluoro-deoxy-Glucose Positron Emission Tomography/Computed Tomography scans in 10 patients with de novo and relapsed acute myeloid leukemia and histologically proven extramedullary disease. The scans were able to detect the known extramedullary lesions in 9 out of 10 patients (90%). Furthermore, additional extramedullary sites were detected in 6 patients (60%). Thus, it is possible to identify known and clinically undetectable extramedullary manifestations of acute myeloid leukemia. Since most of these patients relapsed within a short period of time after initiation of therapy or had refractory disease, the detection of extramedullary disease with (18)Fluoro-deoxy-Glucose Positron Emission Tomography/Computed Tomography might be helpful in the development of individual treatment algorithms for these high-risk patients.
authors.affiliation: Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus Dresden, Germany. friedrich.stoelzel@uniklinikum-dresden.de
authors.forename: Friedrich
authors.initials: F
authors.lastname: Stölzel
authors.forename: Christoph
authors.initials: C
authors.lastname: Röllig
authors.forename: Jörgen
authors.initials: J
authors.lastname: Radke
authors.forename: Brigitte
authors.initials: B
authors.lastname: Mohr
authors.forename: Uwe
authors.initials: U
authors.lastname: Platzbecker
authors.forename: Martin
authors.initials: M
authors.lastname: Bornhäuser
authors.forename: Tobias
authors.initials: T
authors.lastname: Paulus
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ehninger
authors.forename: Klaus
authors.initials: K
authors.lastname: Zöphel
authors.forename: Markus
authors.initials: M
authors.lastname: Schaich
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D023981:Sarcoma, Myeloid / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18