title: Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases.
abstract: Immunoglobulin E (IgE) antibodies have long been recognized as the antigen-specific triggers of allergic reactions. This review briefly introduces the established functions of IgE in immediate hypersensitivity and then focuses on emerging evidence from our own investigations as well as those of others that IgE plays important roles in protective immunity against parasites and exerts regulatory influences in the expression of its own receptors, FcεRI and CD23, as well as controlling mast cell homeostasis. We provide an overview of the multifaceted ways in which IgE antibodies contribute to the pathology of food allergy and speculate regarding potential mechanisms of action of IgE blockade.
authors.affiliation: Division of Immunology, Children's Hospital, Harvard Medical School, Boston, MA, USA. oliver.burton@childrens.harvard.edu
authors.forename: Oliver T
authors.initials: OT
authors.lastname: Burton
authors.forename: Hans C
authors.initials: HC
authors.lastname: Oettgen
mesh_terms: D000328:Adult; D000818:Animals; D002648:Child; D005786:Gene Expression Regulation / Q000276:immunology; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D007109:Immunity; D007073:Immunoglobulin E / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D017455:Receptors, IgE / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology
chemical_list: D017455:Receptors, IgE; D007073:Immunoglobulin E