title: Cataract surgery in eyes with low corneal endothelial cell density.
abstract: OBJECTIVE
  To compare corneal endothelial damage after cataract surgery in eyes with low endothelial cell density (ECD) and eyes with normal ECD.
  
  
  METHODS
  Hayashi Eye Hospital, Fukuoka, Japan.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Cataract surgery was performed in eyes with a low ECD (500 to 1000 cells/mm(2)) (low-density group) and control eyes with a normal ECD. The ECD and central corneal thickness (CCT) were measured preoperatively and 1 and 3 months postoperatively, and the percentage cell loss and increase in CCT were compared.
  
  
  RESULTS
  The low-density group and control group each comprised 50 eyes. In the low-density group, 39 eyes had nonprogressive endothelial pathology and 11 had Fuchs dystrophy. The mean ECD was significantly less and the CCT significantly greater in the low-density group than in the control group throughout the follow-up (P ≤.0066). However, no significant difference in the percentage of cell loss was found between groups at 1 or 3 months (5.1%, low-density group; 4.2%, control group) (P ≥.1477). The percentage increase in CCT was significantly greater in the low-density group than in the control group at 1 month (P<.0001), although there was no significant difference at 3 months (0.4% and -0.4%, respectively) (P=.2172).
  
  
  CONCLUSIONS
  Corneal endothelial damage after cataract surgery in eyes with low ECD was slight and comparable to that in healthy eyes, which suggests that cataract surgery alone (without corneal transplantation) should be performed first.
authors.affiliation: Hayashi Eye Hospital, Fukuoka, Japan. hayashi-ken@hayashi.or.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Hayashi
authors.forename: Motoaki
authors.initials: M
authors.lastname: Yoshida
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Manabe
authors.forename: Akira
authors.initials: A
authors.lastname: Hirata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002387:Cataract Extraction / Q000379:methods*; D002452:Cell Count; D055954:Corneal Endothelial Cell Loss / Q000209:etiology*; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D019591:Pseudophakia / Q000503:physiopathology; D012029:Refraction, Ocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology