title: Prolonged mean reaction time in posterior cerebral artery during visual stimulation in patients with severe carotid stenosis.
abstract: While the mean increase in flow velocities in posterior cerebral artery (PCA) as a response to visual stimuli is well documented, the data on the reaction time as a measurement of the vasomotor response of the posterior part of the circle of Willis are still sparse. The aim was to assess the visual evoked response in PCA during white light stimulation by means of functional transcranial doppler in patients with severe internal carotid artery (ICA) stenosis, to introduce a real-time haemodynamic changes as a measurement of the effect of severe carotid disease on the posterior circulation. The measurements were taken in 49 right-handed patients with severe ICA stenosis or occlusion and 30 healthy volunteers, simultaneously in left and right PCA using 2-MHz probes, successively in the dark and during the white light stimulation, during three consecutive repetitive periods of 1 min each. Mean values of mean blood flow velocities (MBFV) and mean reaction time (MRT) with and without visual stimuli were analysed. Linear regression analysis showed no statistically significant correlation between the age, MBFV and a degree of left and right carotid stenosis, and MRT in left and right PCA either in the group of healthy subjects or in the group of patients with severe carotid stenosis, in both test conditions. MRT could be an indicator of compromised cerebral circulation in the presence of haemodynamic significant carotid stenosis as well as an additional and independent haemodynamic parameter of the cerebral visual evoked response.
authors.affiliation: University Department of Neurology, Sestre milosrdnice University Hospital, Zagreb, Croatia. mroje@mef.hr
authors.forename: Marina Roje
authors.initials: MR
authors.lastname: Bedeković
authors.forename: Arijana
authors.initials: A
authors.lastname: Lovrenčić-Huzjan
authors.forename: Marijana Bosnar
authors.initials: MB
authors.lastname: Puretić
authors.forename: Vida
authors.initials: V
authors.lastname: Demarin
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D016893:Carotid Stenosis / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D020769:Posterior Cerebral Artery / Q000503:physiopathology*; D011930:Reaction Time; D013997:Time Factors