title: A novel hydroxyapatite ceramic bone substitute transformed by ostrich cancellous bone: characterization and evaluations of bone regeneration activity.
abstract: Various biomaterials have been used for bone repair and reconstruction of bone defects. Inorganic xenogenic bone substitutes have been intensively studied because they possesses favorable regenerative properties. The purpose of this study was to evaluate the properties of a novel inorganic xenogenic bone substitute, sintered ostrich cancellous bone (SOCB). Bone regeneration capability was also comparing to that of other bone substitutes in rabbit calvarial defects. Biochemical and biomechanical properties of the SOCB ceramic closely resembled those of human bone. Bone regeneration was evaluated by radiograph, histology, and histomorphometry. Bone regeneration was significantly enhanced in defects treated with SOCB when compared with other bone substitutes. The biochemical and biomechanical properties of SOCB are favorable for bone regeneration. SOCB might be a promising biomaterial for the repair of bone defects.
authors.affiliation: First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka Dental University, Osaka, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sawada
authors.forename: Akishige
authors.initials: A
authors.lastname: Hokugo
authors.forename: Yaowu
authors.initials: Y
authors.lastname: Yang
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kamitani
authors.forename: Sakiko
authors.initials: S
authors.lastname: Matsuda
authors.forename: Tianqiu
authors.initials: T
authors.lastname: Mao
authors.forename: Delin
authors.initials: D
authors.lastname: Lei
authors.forename: Fulin
authors.initials: F
authors.lastname: Chen
authors.forename: Tomio
authors.initials: T
authors.lastname: Iseki
authors.forename: Shosuke
authors.initials: S
authors.lastname: Morita
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D001842:Bone and Bones; D017886:Durapatite / Q000737:chemistry* / Q000627:therapeutic use; D008422:Materials Testing; D011817:Rabbits; D020310:Struthioniformes; D014183:Transplantation, Heterologous
chemical_list: D018786:Bone Substitutes; D017886:Durapatite