title: Synthesis and structure of new bicopper(II) complexes bridged by N-(2- aminopropyl)-N'-(2-oxidophenyl)oxamide: the effects of terminal ligands on structures, anticancer activities and DNA-binding properties.
abstract: A novel dissymmetrical N,N'-bis(substituted)oxamide ligand, N-(2-aminopropyl)-N'-(2-oxido- phenyl)oxamide (H(3)apopoxd) (L), and its three bicopper(II) complexes, [Cu(2)(apopoxd)(bpy)]- (ClO(4))·H(2)O (1), [Cu(2)(apopoxd)(dabt)](ClO(4))·2H(2)O (2), and [Cu(2)(apopoxd)(phen)(2)](ClO(4)) (3) (bpy = 2,2'-bipyridine; dabt = 2,2'-diamino-4,4'-bithiazole; phen = 1,10-phenanthroline) have been synthesized and characterized. The crystal structures of the three bicopper(II) complexes have been determined by X-ray single-crystal diffraction. In complexes 1 and 2, the cis-apopoxd(3-) ligands bridge two copper(II) ions in square-planar geometries with the corresponding separations of 5.1868(3) and 5.2016(4) Å, respectively. While in complex 3, the apopoxd(3-) ligand adopting a trans conformation bridges the two copper(II) ions in distorted square-pyramid environments with a Cu · · · Cu distance of 5.2508(7) Å. The anticancer activities and DNA-binding properties of L and the three complexes were investigated.
authors.affiliation: Marine Drug & Food Institute, Ocean University of China, 5 Yu shan Road, Qingdao 266003, PR China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Li
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Zheng
authors.forename: Yan-Tuan
authors.initials: YT
authors.lastname: Li
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Wu
authors.forename: Cui-Wei
authors.initials: CW
authors.lastname: Yan
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D010072:Oxamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014783:Viscosity
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D003300:Copper; D004247:DNA; D010072:Oxamic Acid