title: MDS Task Force on mild cognitive impairment in Parkinson's disease: critical review of PD-MCI.
abstract: There is controversy regarding the definition and characteristics of mild cognitive impairment in Parkinson's disease. The Movement Disorder Society commissioned a Task Force to critically evaluate the literature and determine the frequency and characteristics of Parkinson's disease-mild cognitive impairment and its association with dementia. A comprehensive PubMed literature review was conducted using systematic inclusion and exclusion criteria. A mean of 26.7% (range, 18.9%-38.2%) of nondemented patients with Parkinson's disease have mild cognitive impairment. The frequency of Parkinson's disease-mild cognitive impairment increases with age, disease duration, and disease severity. Impairments occur in a range of cognitive domains, but single domain impairment is more common than multiple domain impairment, and within single domain impairment, nonamnestic is more common than amnestic impairment. A high proportion of patients with Parkinson's disease-mild cognitive impairment progress to dementia in a relatively short period of time. The primary conclusions of the Task Force are that: (1) Parkinson's disease-mild cognitive impairment is common, (2) there is significant heterogeneity within Parkinson's disease-mild cognitive impairment in the number and types of cognitive domain impairments, (3) Parkinson's disease-mild cognitive impairment appears to place patients at risk of progressing to dementia, and (4) formal diagnostic criteria for Parkinson's disease-mild cognitive impairment are needed.
authors.affiliation: Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky, USA. i.litvan@louisville.edu
authors.forename: Irene
authors.initials: I
authors.lastname: Litvan
authors.forename: Dag
authors.initials: D
authors.lastname: Aarsland
authors.forename: Charles H
authors.initials: CH
authors.lastname: Adler
authors.forename: Jennifer G
authors.initials: JG
authors.lastname: Goldman
authors.forename: Jaime
authors.initials: J
authors.lastname: Kulisevsky
authors.forename: Brit
authors.initials: B
authors.lastname: Mollenhauer
authors.forename: Maria C
authors.initials: MC
authors.lastname: Rodriguez-Oroz
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Tröster
authors.forename: Daniel
authors.initials: D
authors.lastname: Weintraub
mesh_terms: D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications*