title: Pneumocystis jirovecii colonization in chronic pulmonary disease.
abstract: Pneumocystis jirovecii causes pneumonia in immunosuppressed individuals. However, it has been reported the detection of low levels of Pneumocystis DNA in patients without signs and symptoms of pneumonia, which likely represents colonization. Several studies performed in animals models and in humans have demonstrated that Pneumocystis induces a local and a systemic response in the host. Since P jirovecii colonization has been found in patients with chronic pulmonary diseases it has been suggested that P jirovecii may play a role in the physiopathology and progression of those diseases. In this report we revise P. jirovecii colonization in different chronic pulmonary diseases such us, chronic obstructive pulmonary disease, interstitial lung diseases, cystic fibrosis and lung cancer.
authors.affiliation: Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. anisoguri@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Gutiérrez
authors.forename: N
authors.initials: N
authors.lastname: Respaldiza
authors.forename: E
authors.initials: E
authors.lastname: Campano
authors.forename: M T
authors.initials: MT
authors.lastname: Martínez-Risquez
authors.forename: E J
authors.initials: EJ
authors.lastname: Calderón
authors.forename: C
authors.initials: C
authors.lastname: De La Horra
mesh_terms: D000818:Animals; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000382:microbiology*; D008175:Lung Neoplasms / Q000150:complications / Q000382:microbiology*; D045363:Pneumocystis carinii / Q000254:growth & development* / Q000502:physiology; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000382:microbiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000382:microbiology*; D055752:Small Cell Lung Carcinoma / Q000150:complications / Q000382:microbiology