title: Challenges for emerging neurostimulation-based therapies for real-time seizure control.
abstract: In step with the worthwhile aim of this special issue, two junior investigators impart their insights on the therapeutic challenges imposed by pharmacoresistant epilepsies and offer viable approaches to improvement of treatment outcomes. Sunderam's comprehensive perspective addresses issues of critical importance for the design of efficacious therapies. Talathi delves into the thorny roles of so-called "interictal" spikes in ictio- and epileptogenesis, roles that are central to understanding the dynamics of these phenomena and implicitly of how to prevent them or abort them. First, however, Osorio and co-workers illustrate the complex behavior of the epileptogenic network and point to the importance of real-time intraindividual adaptation and optimization of therapies for seizures originating from the same epileptogenic network.
authors.affiliation: University of Kentucky, Center for Biomedical Engineering, USA.
authors.forename: Sridhar
authors.initials: S
authors.lastname: Sunderam
authors.forename: Sachin S
authors.initials: SS
authors.lastname: Talathi
authors.forename: Alexey
authors.initials: A
authors.lastname: Lyubushin
authors.forename: Didier
authors.initials: D
authors.lastname: Sornette
authors.forename: Ivan
authors.initials: I
authors.lastname: Osorio
mesh_terms: D004599:Electric Stimulation Therapy / Q000379:methods / Q000639:trends*; D004569:Electroencephalography; D004827:Epilepsy / Q000628:therapy*; D006801:Humans; D058542:Implantable Neurostimulators / Q000639:trends*; D019581:Neuropil / Q000502:physiology; D012640:Seizures / Q000628:therapy*; D012890:Sleep / Q000502:physiology