title: Regulation of appetite to treat obesity.
abstract: Obesity has escalated into a pandemic over the past few decades. In turn, research efforts have sought to elucidate the molecular mechanisms underlying the regulation of energy balance. A host of endogenous mediators regulate appetite and metabolism, and thereby control both short- and long-term energy balance. These mediators, which include gut, pancreatic and adipose neuropeptides, have been targeted in the development of anti-obesity pharmacotherapy, with the goal of amplifying anorexigenic and lipolytic signaling or blocking orexigenic and lipogenic signaling. This article presents the efficacy and safety of these anti-obesity drugs.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 S. 10th Street, 1170 Main, Philadelphia, PA 19107, USA.
authors.forename: Gilbert W
authors.initials: GW
authors.lastname: Kim
authors.forename: Jieru E
authors.initials: JE
authors.lastname: Lin
authors.forename: Michael A
authors.initials: MA
authors.lastname: Valentino
authors.forename: Francheska
authors.initials: F
authors.lastname: Colon-Gonzalez
authors.forename: Scott A
authors.initials: SA
authors.lastname: Waldman
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D001069:Appetite Regulation / Q000187:drug effects* / Q000502:physiology*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D019440:Anti-Obesity Agents