title: A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging.
abstract: The first highly selective and sensitive fluorescent probe Z1 for detection of carbonic anhydrase IX (CA IX) over isoforms CA I and CA II was developed. As demonstrated, Z1 worked effectively in both enzymatic systems and living hypoxia cells.
authors.affiliation: State Key Laboratory of Bioreactor Engineering, School of Pharmacy East China University of Science and Technology, Meilong Road 130, Shanghai, 200237, China.
authors.forename: Shenyi
authors.initials: S
authors.lastname: Zhang
authors.forename: Chunmei
authors.initials: C
authors.lastname: Yang
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Lu
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Weiping
authors.initials: W
authors.lastname: Zhu
authors.forename: Honglin
authors.initials: H
authors.lastname: Li
authors.forename: Yufang
authors.initials: Y
authors.lastname: Xu
authors.forename: Xuhong
authors.initials: X
authors.lastname: Qian
mesh_terms: D000951:Antigens, Neoplasm / Q000737:chemistry* / Q000378:metabolism; D024401:Carbonic Anhydrase I / Q000737:chemistry / Q000378:metabolism; D024402:Carbonic Anhydrase II / Q000737:chemistry / Q000378:metabolism; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases / Q000737:chemistry* / Q000378:metabolism; D002460:Cell Line; D004579:Electron Transport; D005456:Fluorescent Dyes / Q000737:chemistry*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence; D010879:Piperazines / Q000737:chemistry*
chemical_list: D000951:Antigens, Neoplasm; D005456:Fluorescent Dyes; D006575:Heterocyclic Compounds, 3-Ring; D010879:Piperazines; C562017:fluorescent probe Z1; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II; C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases