title: Analgesic and antiinflammatory activity of kaur-16-en-19-oic acid from Annona reticulata L. bark.
abstract: Kaur-16-en-19-oic acid was isolated from the bark of Annona reticulata and studied for its analgesic and antiinflammatory activity. Analgesic activity was assessed using the hot plate test and acetic acid-induced writhing, and the antiinflammatory activity using the carrageenan induced rat paw oedema method. Kaur-16-en-19-oic acid, at doses of 10 and 20 mg/kg, exhibited significant (p < 0.05) analgesic and antiinflammatory activity. These activities were comparable to the standard drugs used, and furthermore the analgesic effect of kaur-16-en-19-oic acid was blocked by naloxone (2 mg/kg) in both analgesic models.
authors.affiliation: Department of Pharmacognosy, Amrutvahini College of Pharmacy, Sangamner, Dist-Ahmednagar (M.S), Pin. 422608, India.
authors.forename: Machindra J
authors.initials: MJ
authors.lastname: Chavan
authors.forename: Dinesh R
authors.initials: DR
authors.lastname: Kolhe
authors.forename: Pravin S
authors.initials: PS
authors.lastname: Wakte
authors.forename: Devanand B
authors.initials: DB
authors.lastname: Shinde
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D031041:Annona / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan; D004224:Diterpenes / Q000494:pharmacology; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D010936:Plant Extracts; C014341:argyrophilic acid; D002351:Carrageenan; D019342:Acetic Acid