title: Fenofibrate: altered renal function.
abstract: In patients with type 2 diabetes, a subgroup analysis of a placebo-controlled trial of fenofibrate showed a significant decline in calculated creatinine clearance with fenofibrate. Most fibrates seem to have a detrimental effect on renal function, with the probable exception of gemfibrozil, which is the fibrate of choice in the few situations in which a fibrate is needed.
mesh_terms: D003404:Creatinine / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D011345:Fenofibrate / Q000009:adverse effects* / Q000627:therapeutic use; D005919:Glomerular Filtration Rate; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D007677:Kidney Function Tests
chemical_list: D000960:Hypolipidemic Agents; D003404:Creatinine; D011345:Fenofibrate