title: Grand network convergence.
abstract: A report of the Systems Biology: Networks meeting, Cold Spring Harbor, USA, 22-26 March 2011.The success of the human genome project has provided a model for an analogous interactome project to map how proteins, genes, metabolites and other regulatory components interact to transform a biochemical soup into a living system. These maps promise to serve as a framework for models that predict how a biological system responds to a perturbation or an input, which is relevant to gene mutations and therapeutic treatment in human disease, and as a framework for designing new systems in synthetic biology.Three major themes arose during the 2011 meeting: technological drivers and data generation, algorithmic advances, and convergence on biological applications with context-sensitive networks.
authors.affiliation: Department of Biomedical Engineering and High-Throughput Biology Center, Johns Hopkins University, Baltimore, MD 21218, USA. joel.bader@jhu.edu.
authors.forename: Joel S
authors.initials: JS
authors.lastname: Bader
mesh_terms: D000465:Algorithms; D001709:Biotechnology; D019295:Computational Biology; D057225:Data Mining; D053263:Gene Regulatory Networks; D006801:Humans; D053858:Metabolic Networks and Pathways; D015398:Signal Transduction