title: [Inhibition of DD2R gene expression in the corpus allatum activates alkaline phosphatase in female Drosophila melanogaster].
abstract: Tissue-specific inhibition of the expression of the D2-like dopamine receptor gene (DD2R) in the corpus allatum (CA), which is a gland that synthesizes the juvenile hormone (JH), was tested for effect on alkaline phosphatase (AP) activity and the intensity of the AP response to heat stress (stress reactivity) in female Drosophila melanogaster. AP activity and AP stress reactivity in transgenic females with lower DD2R expression in the CA were higher than in control flies. A pharmacological elevation in JH increased AP activity in females of the control strains. DD2R was assumed to mediate the inhibitory effect of dopamine of JH synthesis in the CA of D. melanogaster.
authors.forename: E V
authors.initials: EV
authors.lastname: Bogomolova
authors.forename: N V
authors.initials: NV
authors.lastname: Adon'eva
authors.forename: N V
authors.initials: NV
authors.lastname: Faddeeva
authors.forename: N E
authors.initials: NE
authors.lastname: Gruntenko
authors.forename: I Yu
authors.initials: IY
authors.lastname: Raushenbakh
mesh_terms: D000469:Alkaline Phosphatase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D030801:Animals, Genetically Modified; D003335:Corpora Allata / Q000378:metabolism; D004298:Dopamine / Q000235:genetics / Q000378:metabolism; D065127:Dopamine D2 Receptor Antagonists; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D015971:Gene Expression Regulation, Enzymologic; D006358:Hot Temperature; D007605:Juvenile Hormones / Q000235:genetics / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000235:genetics / Q000378:metabolism; D013312:Stress, Physiological / Q000502:physiology
chemical_list: D065127:Dopamine D2 Receptor Antagonists; D007605:Juvenile Hormones; D017448:Receptors, Dopamine D2; D000469:Alkaline Phosphatase; D004298:Dopamine