title: The amount of surface HLA-I on T lymphocytes decreases in breast infiltrating ductal carcinoma patients.
abstract: Human leucocyte antigen class I (HLA-I), which includes HLA-A, -B and -C, is an essential immune factor participating in the antitumour immune response. The changes in HLA-I expression in peripheral blood T lymphocytes in cancer patients have yet to be defined. This study examined the expression of HLA-I on CD4(+) and CD8(+) T lymphocytes in female patients with stage I - IV breast infiltrating ductal carcinoma, benign breast tumour diseases (mammary intraductal papilloma or breast fibroadenoma), and in healthy controls. HLA-I was down-regulated on CD4(+) T lymphocytes from patients with stage III and IV cancer, and on CD8(+) T lymphocytes in patients with stage I - IV cancer compared with healthy controls. HLA-I expression in T lymphocytes may contribute towards immune-balance disorders in tumour patients.
authors.affiliation: Department of Clinical Laboratory Medicine, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.forename: N
authors.initials: N
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: F
authors.initials: F
authors.lastname: Wan
authors.forename: X
authors.initials: X
authors.lastname: Zou
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018270:Carcinoma, Ductal, Breast / Q000276:immunology* / Q000473:pathology; D005260:Female; D005453:Fluorescence; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015395:Histocompatibility Antigens Class I