title: Severe human herpesvirus 6-associated encephalopathy in three children: analysis of cytokine profiles and the carnitine palmitoyltransferase 2 gene.
abstract: Three children developed severe encephalopathy associated with human herpesvirus 6 infection. Magnetic resonance imaging of the brain showed either basal ganglia involvement or diffusion abnormalities in the cerebral white matter. Coagulopathy with hypercytokinemia was observed in 2 patients. One demonstrated thermolabile variation in carnitine palmitoyltransferase 2. These results suggest a heterogeneous pathogenic mechanism in encephalopathy associated with human herpesvirus 6 infection.
authors.affiliation: Department of Pediatrics, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan. matumoto@ndmc.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hatanaka
authors.forename: Yumi
authors.initials: Y
authors.lastname: Ogura
authors.forename: Ayako
authors.initials: A
authors.lastname: Chida
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Nonoyama
mesh_terms: D001479:Basal Ganglia / Q000201:enzymology / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D015415:Biomarkers / Q000097:blood; D001928:Brain Diseases, Metabolic / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D002334:Carnitine O-Palmitoyltransferase / Q000097:blood; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood / Q000276:immunology; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D004569:Electroencephalography; D018792:Encephalitis, Viral / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D005260:Female; D015654:Herpesvirus 6, Human; D006801:Humans; D007223:Infant; D007564:Japan; D008279:Magnetic Resonance Imaging; D020258:Neurotoxicity Syndromes / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D016133:Polymerase Chain Reaction; D019349:Roseolovirus Infections / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D058408:Th1-Th2 Balance
chemical_list: D015415:Biomarkers; D016207:Cytokines; D002334:Carnitine O-Palmitoyltransferase