title: VGCC antibody-positive paraneoplastic cerebellar degeneration presenting with positioning vertigo.
abstract: A 70-year-old woman developed paraneoplastic cerebellar degeneration (PCD) due to P/Q-type and N-type voltage-gated calcium channel antibodies and small cell lung cancer, the main clinical manifestations of which were severe positioning vertigo and vomiting. Loss of the visual suppression of caloric nystagmus, spontaneous downbeat nystagmus, periodic alternating nystagmus, and positioning vertigo in our patient most probably corresponds to the cerebellar flocculus/paraflocculus lesion caused by PCD.
authors.affiliation: Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura 285-8741, Japan.
authors.forename: Emina
authors.initials: E
authors.lastname: Ogawa
authors.forename: Ryuji
authors.initials: R
authors.lastname: Sakakibara
authors.forename: Kengo
authors.initials: K
authors.lastname: Kawashima
authors.forename: Tomoe
authors.initials: T
authors.lastname: Yoshida
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kishi
authors.forename: Fuyuki
authors.initials: F
authors.lastname: Tateno
authors.forename: Manabu
authors.initials: M
authors.lastname: Kataoka
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kawashima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D000906:Antibodies / Q000097:blood*; D020864:Calcium Channels, N-Type / Q000276:immunology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D020362:Paraneoplastic Cerebellar Degeneration / Q000097:blood* / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D020886:Somatosensory Disorders / Q000150:complications; D013909:Thorax / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014717:Vertigo / Q000150:complications* / Q000175:diagnosis
chemical_list: D000906:Antibodies; D020864:Calcium Channels, N-Type