title: A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG.
abstract: We present results from continuous intracranial electroencephalographic (iEEG) monitoring in 6 dogs with naturally occurring epilepsy, a disorder similar to the human condition in its clinical presentation, epidemiology, electrophysiology and response to therapy. Recordings were obtained using a novel implantable device wirelessly linked to an external, portable real-time processing unit. We demonstrate previously uncharacterized intracranial seizure onset patterns in these animals that are strikingly similar in appearance to human partial onset epilepsy. We propose: (1) canine epilepsy as an appropriate model for testing human antiepileptic devices and new approaches to epilepsy surgery, and (2) this new technology as a versatile platform for evaluating seizures and response to therapy in the natural, ambulatory setting.
authors.affiliation: Department of Neurology, University of Pennsylvania, United States; Penn Epilepsy Center, United States. Kathryn.Davis@uphs.upenn.edu
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Davis
authors.forename: Beverly K
authors.initials: BK
authors.lastname: Sturges
authors.forename: Charles H
authors.initials: CH
authors.lastname: Vite
authors.forename: Vanessa
authors.initials: V
authors.lastname: Ruedebusch
authors.forename: Gregory
authors.initials: G
authors.lastname: Worrell
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Gardner
authors.forename: Kent
authors.initials: K
authors.lastname: Leyde
authors.forename: W Douglas
authors.initials: WD
authors.lastname: Sheffield
authors.forename: Brian
authors.initials: B
authors.lastname: Litt
mesh_terms: D000465:Algorithms; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D004285:Dogs; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation* / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary; D005260:Female; D008297:Male; D008991:Monitoring, Physiologic; D013686:Telemetry / Q000295:instrumentation* / Q000379:methods; D014851:Wakefulness
chemical_list: D000927:Anticonvulsants