title: Site of venous thromboembolism and prothrombotic mutations according to body mass index. Results from the EDITH study.
abstract: This study evaluated the impact of body mass index (BMI) on venous thromboembolism (VTE) site and assessed a possible interaction between BMI and prothrombotic risk factors in patients included in the EDITH (Etude des Déterminants et Interactions de le THrombose veineuse) study. A cross-sectional study was used to compare the site of unprovoked VTE according to BMI categories in 1077 patients and a matched case-control study (732 pairs) assessed the joint effect of BMI and prothrombotic mutations on VTE risk. The cross sectional analysis showed that the proportion of patients with pulmonary embolism was higher in overweight (63%) and obese (63·5%) patients than among patients with a BMI<25kg/m(2) (55%), P=0·02 and P=0·05 respectively. No interaction was found between F5 G1691A (factor V Leiden) and BMI for VTE risk (P=0·90). There was a significant interaction between F2 G20210A and BMI (P=0·02). The risk of VTE associated with BMI was 1·7 [95% confidence interval (CI): 0·8-3·7], 4·36 (95%CI: 1·49-12·78) and 12·03 (95%CI: 1·53-94·29) in patients with BMI<25kg/m(2) , 25≤BMI<30 and ≥30kg/m(2) respectively after adjustment for age and oestrogen use. This study showed that BMI may play a role in determining the site of VTE and may interact with F2 G20210A but not with F5 G1691A for the risk of VTE.
authors.affiliation: Université Européenne de Bretagne EA 3878, IFR 148, Université de Brest, 29609 Brest, France. aurelien.delluc@chu-brest.fr
authors.forename: Aurélien
authors.initials: A
authors.lastname: Delluc
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Le Moigne
authors.forename: Cécile
authors.initials: C
authors.lastname: Tromeur
authors.forename: Elise
authors.initials: E
authors.lastname: Noel-Savina
authors.forename: Francis
authors.initials: F
authors.lastname: Couturaud
authors.forename: Dominique
authors.initials: D
authors.lastname: Mottier
authors.forename: Grégoire
authors.initials: G
authors.lastname: Le Gal
authors.forename: Karine
authors.initials: K
authors.lastname: Lacut
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D004812:Epidemiologic Methods; D005165:Factor V / Q000235:genetics; D005260:Female; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D011516:Prothrombin / Q000235:genetics*; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D054556:Venous Thromboembolism / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D055815:Young Adult
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin