title: ABCB5 in peripheral blood of a patient affected by multiple primary malignancies.
abstract: BACKGROUND
  Multiple primary neoplasm malignancies syndrome (MPMN), is the presence of two or more abnormal growths of tissue, occurring simultaneously. Although the number of second malignancies is increasing, due to several factors, the presence of triple or quadruple malignancies is still very rare.
  
  
  METHODS
  We report a case of a 78-year-old man, with six primaries: a prostatic adenocarcinoma, breast cancer, two melanoma, a basal cell carcinoma, and a lymphoma in a four years period.
  
  
  RESULTS
  The onset of MPMN is probably caused by a mutation of DNA repair genes, probably the TP53 gene. Common features of this syndrome are early rise and low tendency to metastatize. We reviewed the markers of staminality for various tumors: RNA expression of ALDH1, CD 133, and ABCB 5, extracted from the sentinel lymph node (SLN) and from the peripheral blood of the patient, was verified.
  
  
  CONCLUSIONS
  People with multiple tumors represent a segment of the cancer-survivor population, which is continuously increasing (10%). Several genetic mutation can be involved in this kind of population. Our patient was positive for the expression of ABCB5, a marker for staminality of melanoma, in periphal blood.
authors.affiliation: Department of Surgery Unit of Plastic Surgery, Sapienza University of Rome, Italy. emanuelecigna@msn.com
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cigna
authors.forename: Angela
authors.initials: A
authors.lastname: Gradilone
authors.forename: Valentina
authors.initials: V
authors.lastname: Sorvillo
authors.forename: Nicolò
authors.initials: N
authors.lastname: Scuderi
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000097:blood*; D000368:Aged; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000097:blood*
chemical_list: C480744:ABCB5 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1