title: Does staged closure have a worse prognosis in gastroschisis?
abstract: BACKGROUND
  Correction of gastroschisis can be accomplished by primary or staged closure. There is, however, no consensus regarding the best approach or criteria to favor one method over the other has been established.
  
  
  OBJECTIVE
  To compare the outcome of primary and staged closure in newborns with gastroschisis using intravesical pressure (IVP) as the decision criterion.
  
  
  METHODS
  We prospectively analyzed 45 newborns with gastroschisis. An IVP with a threshold of 20 cm H(2)O was used to indicate primary or staged closure, and the outcomes between the two methods were compared.
  
  
  CONCLUSIONS
  Newborns in whom primary closure was feasible were born at a lower gestational age. There was no significant difference in the frequency of complications, time to begin oral feeding, length of parenteral nutrition or length of hospital stay. Compared with previous reports, our data showed higher rates of prenatal diagnosis and cesarean delivery, a lower average birth weight, a higher rate of small gestational age babies and a more frequent association with intestinal atresia. Conversely, our data showed a lower rate of postoperative necrotizing enterocolitis and a lower average length of hospital stay.
  
  
  CONCLUSIONS
  No significant difference was observed in the outcome of newborns who underwent primary closure or staged closure of gastroschisis when using an IVP below 20 cm H(2)O as the criterion for primary closure.
authors.affiliation: Discipline of Pediatric Surgery, Department of Surgery, School of Medical Sciences, State University of Campinas, Brazil.
authors.forename: Augusto Frederico
authors.initials: AF
authors.lastname: Schmidt
authors.forename: Anderson
authors.initials: A
authors.lastname: Gonçalves
authors.forename: Joaquim Murray
authors.initials: JM
authors.lastname: Bustorff-Silva
authors.forename: Antônio Gonçalves
authors.initials: AG
authors.lastname: Oliveira Filho
authors.forename: Sergio Tadeu
authors.initials: ST
authors.lastname: Marba
authors.forename: Lourenco
authors.initials: L
authors.lastname: Sbragia
mesh_terms: D058107:Abdominal Wound Closure Techniques / Q000009:adverse effects*; D003657:Decision Making; D020139:Gastroschisis / Q000175:diagnosis / Q000601:surgery*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011183:Postoperative Complications / Q000453:epidemiology; D011312:Pressure; D011379:Prognosis; D011446:Prospective Studies; D016896:Treatment Outcome