title: Iron/dextran sulfate multilayered microcapsules for controlled release of 10-hydroxycamptothecin.
abstract: Stable 10-hydroxycamptothecin (HCPT) microcrystals with a length of about 5-10μm and a ζ-potential of -38.5mV were produced by pH-induced reprecipitation in presence of a stabilizer hydroxypropylmethylcellulose. Sequential layer growth was achieved by the layer-by-layer (LbL) assembly of Fe(3+) and dextran sulfate (DS) on the surface of HCPT microcrystals via both electrostatic interaction and chemical complexation process. The satisfactory drug loading content (67.2±0.82%) as well as high encapsulation efficiency (60.56±0.82%) for four bilayers of Fe(3+)/DS coating was achieved. Both in vitro and in vivo release study revealed that the release time increased as the number of deposited Fe(3+)/DS bilayers increased. These results indicated that such iron-polysaccharide multilayered microcapsules can be a promising approach for the construction of an effective controlled release delivery system of HCPT as well as other drugs with potential cytotoxicity or short half-life time.
authors.affiliation: Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Harbin 150040, People's Republic of China.
authors.forename: Shenglei
authors.initials: S
authors.lastname: Guo
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Na
authors.initials: N
authors.lastname: Guo
authors.forename: Lijia
authors.initials: L
authors.lastname: Jing
authors.forename: Xiuli
authors.initials: X
authors.lastname: Yue
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Yan
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Dai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000493:pharmacokinetics*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D002214:Capsules; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D016264:Dextran Sulfate / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008297:Male; D051379:Mice; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D016264:Dextran Sulfate; C028098:10-hydroxycamptothecin; D007501:Iron; D002166:Camptothecin