title: Congenital heart disease infant death rates decrease as gestational age advances from 34 to 40 weeks.
abstract: OBJECTIVE
  To describe congenital heart disease death rates in infants born between 34 and 40 weeks, estimate the relationship between gestational age and congenital heart disease infant death rates, and compare congenital heart disease death rates across 1- and 2-week intervals in gestational age.
  
  
  METHODS
  The 2000 to 2003 national linked birth/infant death cohort datasets were obtained. Congenital heart disease deaths were identified by using International Statistical Classification of Diseases, 10th Revision codes. Proportional death rates were calculated by using congenital heart disease deaths and all live births. The relationship between congenital heart disease death rates and gestational age was determined. Death rates were compared across intervals.
  
  
  RESULTS
  A total of 14.9 million records were analyzed. Congenital heart disease deaths occurred in 4736 infants (0.04%) born between 34 and 40 weeks. There was a significant, negative linear relationship between congenital heart disease death rate and gestational age (R(2) = 0.97). Comparisons across 1-week intervals varied (P = .02-.23). All 2-week intervals were statistically significant (P < .01).
  
  
  CONCLUSIONS
  Congenital heart disease death rates decrease as gestational age approaches 40 weeks. These results should be considered before elective delivery for the sole indication of prenatally diagnosed congenital heart disease.
authors.affiliation: The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. james.cnota@cchmc.org
authors.forename: James F
authors.initials: JF
authors.lastname: Cnota
authors.forename: Resmi
authors.initials: R
authors.lastname: Gupta
authors.forename: Erik C
authors.initials: EC
authors.lastname: Michelfelder
authors.forename: Richard F
authors.initials: RF
authors.lastname: Ittenbach
mesh_terms: D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000401:mortality*; D006801:Humans; D007231:Infant, Newborn; D009309:National Center for Health Statistics, U.S.; D014481:United States