title: Allosteric P═O-based receptors for dicarboxylic acids.
abstract: The synthesis of new P═O-disubstituted receptors with appended crown ethers and their properties as receptors for dicarboxylic acids have been studied. High affinities have been observed (oxalic and malonic acids with 4-, 5-, 6-, or 8-crown ethers). Binding of a cationic effector within the crown ether unit resulted in a positive "allosteric" effect, which has been determined to be K(rel) = 7 in the best case (binding of malonic acid with Li(+) @ rac-3b).
authors.affiliation: ICIQ, Institut Català d'Investigació Química, Avda. Països Catalans, 16, 43007 Tarragona, Spain.
authors.forename: D Amilan
authors.initials: DA
authors.lastname: Jose
authors.forename: Ignasi
authors.initials: I
authors.lastname: Mon
authors.forename: Héctor
authors.initials: H
authors.lastname: Fernández-Pérez
authors.forename: Eduardo C
authors.initials: EC
authors.lastname: Escudero-Adán
authors.forename: J
authors.initials: J
authors.lastname: Benet-Buchholz
authors.forename: Anton
authors.initials: A
authors.lastname: Vidal-Ferran
mesh_terms: D043844:Crown Ethers / Q000138:chemical synthesis / Q000737:chemistry; D018360:Crystallography, X-Ray; D003998:Dicarboxylic Acids / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry; D008968:Molecular Conformation; D019815:Oxalic Acid / Q000737:chemistry; D010078:Oxazines; D011743:Pyrimidines
chemical_list: D043844:Crown Ethers; D003998:Dicarboxylic Acids; D008314:Malonates; D010078:Oxazines; D011743:Pyrimidines; C062254:6H,8H-3,4-dihydropyrimido(4,5-c)(1,2)oxazin-7-one; D019815:Oxalic Acid; C030290:malonic acid