title: Treatment with rtPA of stroke associated with intravenous immunoglobulins perfusion.
abstract: Information about the security of intravenous recombinant tissue type plasminogen activator (rtPA) in immunoglobulins related stroke can only be ascertained from singular cases as it was not assessed in clinical trials. Only two cases of stroke associated with IVIg treated with rtPA were described in literature. We report the outcome of two patients with IVIg associated stroke that were treated with rtPA. In our patients there were hemorrhagic complications - remote cerebral haemorrhage and diffuse cutaneous hematomas.
authors.affiliation: Department of Neurology, Stroke Unit, Hospital de Santa Maria, Lisboa, Portugal. catarinagfonseca@gmail.com
authors.forename: Ana Catarina
authors.initials: AC
authors.lastname: Fonseca
authors.forename: Ruth
authors.initials: R
authors.lastname: Geraldes
authors.forename: Vânia
authors.initials: V
authors.lastname: Almeida
authors.forename: Teresa
authors.initials: T
authors.lastname: Pinho e Melo
mesh_terms: D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000009:adverse effects / Q000379:methods; D011994:Recombinant Proteins / Q000008:administration & dosage; D020521:Stroke / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator