title: Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: a case-control study in a Han Chinese population.
abstract: 1. Aldosterone is a hormone that affects both blood pressure and glucose homeostasis. We studied the association of the aldosterone synthase gene (CYP11B2) polymorphism -344T>C with essential hypertension (EH) and glucose homeostasis in people in China. 2. We investigated the polymorphism -344T>C in CYP11B2 using a case-control study design (1059 cases and 1120 controls). Genotyping was carried out by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy using a MassARRAY platform. 3. The aldosterone synthase gene -344T>C polymorphism was found to be associated with EH (odds ratio 1.252; 95% confidence interval 1.067-1.468; P(add) = 0.006). The -344C variant was found to be significantly associated with increased systolic blood pressure (P(add) = 0.003) and diastolic blood pressure (P(add) = 0.024) in controls and increased plasma aldosterone levels (P(add) = 0.0001) in EH cases. The -344C variant was also found to be significantly associated with increased fasting glucose (P(rec) = 0.003) in controls. In the subgroup containing 893 EH cases without a history of diabetes or hypoglycaemia medications, the -344C variant was found to be associated with increased fasting and postprandial plasma glucose levels (P(add) = 0.0001, P(add) = 0.001, respectively) and decreased pancreatic β-cell function and insulin sensitivity (P(add) = 0.030, P(dom) = 0.019, respectively) by homeostasis model assessments. 4. In this Han Chinese population, the -344T/C polymorphism of the CYP11B2 gene was found to be associated with EH and glucose homeostasis, both of which might be mediated by plasma aldosterone levels, insulin sensitivity and β-cell function.
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Shanghai, China.
authors.forename: Xiao-Mu
authors.initials: XM
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Ling
authors.forename: Da-Ru
authors.initials: DR
authors.lastname: Lu
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Lu
authors.forename: Qian-Lu
authors.initials: QL
authors.lastname: Yi
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
mesh_terms: D000450:Aldosterone / Q000097:blood / Q000235:genetics; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D019405:Cytochrome P-450 CYP11B2 / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic
chemical_list: D001786:Blood Glucose; D000450:Aldosterone; D019405:Cytochrome P-450 CYP11B2