title: [A case of marked efficacy of low-dose UFT against metastatic bladder cancer].
abstract: The two regimens of treatment consisted of either cisplatin and gemcitabine or methotrexate, vinblastine, doxorubicin and cisplatin(M-VAC), which has been widely adopted for muscle-invasive bladder cancer. But because of its potential toxicity, its tolerability has been troublesome, especially for very elderly patients. Herein, we report a bladder cancer case with multiple metastases which were controlled by low-dose UFT. At the same time, the chemosensitivity of 5-FU combined with uracylor 5-chloro-2, 4-dihydroxypyridine(CDHP). Four invasive bladder cancer cell lines were evaluated with a collagen gel droplet embedded drug sensitivity test(CD-DST). Three of four cell lines showed an increasing sensitivity to 5-FU with the combination of uracilor CDHP. Examinations with CD-DST may provide important scientific evidence for determining suitable chemotherapy for patients with advanced bladder cancer.
authors.affiliation: Dept. of Urology, Sen-en General Hospital, Tohoku University Graduate School of Medicine.
authors.forename: Makoto
authors.initials: M
authors.lastname: Satoh
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakano
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kuwahara
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ito
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Arai
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D012008:Recurrence; D005641:Tegafur / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014498:Uracil / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D005641:Tegafur; D014498:Uracil