title: Isolation of novel phenolic compounds with multidrug resistance (MDR) reversal properties from Onychium japonicum.
abstract: We isolated seven novel compounds, namely, 3',4',6-trihydroxy-2,4-dimethoxy-3-(3″,4″-dihydroxybenzyl)chalcone (1), 3',6-dihydroxy-2,4,4'-trimethoxy-3-(3″,4″-dihydroxybenzyl)chalcone (2), α,β-dihydro-3',6-dihydroxy-2,4,6'-trimethoxy-3-(3″,4″-dihydroxybenzyl)chalcone (3), 3',4,4'-trihydroxy-2,6-dimethoxychalcone (4), 4',5,7-trihydroxy-6-(3″,4″-dihydroxybenzyl)flavone (5), 3-(3',4'-dihydroxybenzyl)-6,7-dihydroxycoumarin (6), 3-(3',4'-dihydroxyphenyl)-3,4-dihydroisocoumarin (7), as well as a known compound, 3',4',7-trihydroxy-5-methoxyflavanone (8) from the whole grass of Onychium japonicum, and elucidated their structures by spectroscopic methods. Compounds 1-3 exhibited significant multidrug resistance (MDR) reversal effects on MCF-7/ADR and Bel-7402/5-Fu cell lines.
authors.affiliation: School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, P. R. China.
authors.forename: Ming-Chan
authors.initials: MC
authors.lastname: Li
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yao
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Shen-An
authors.initials: SA
authors.lastname: Tang
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Duan
mesh_terms: D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D029625:Pteridaceae / Q000737:chemistry*
chemical_list: D010636:Phenols