title: Monasnicotinates A-D, four new pyridine alkaloids from the fungal strain Monascus pilosus BCRC 38093.
abstract: Four new pyridine derivatives, monasnicotinates A-D (1-4) were isolated from the red yeast rice of Monascus pilosus BCRC 38093. Their structures were elucidated on the basis of physicochemical evidence, in-depth NMR spectroscopic analysis, and high-resolution mass spectrometry. Their inhibitory effects on NO production was also evaluated.
authors.affiliation: Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan. wmd@firdi.org.tw
authors.forename: Ming-Der
authors.initials: MD
authors.lastname: Wu
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Yech
authors.forename: Yen-Lin
authors.initials: YL
authors.lastname: Chen
authors.forename: Kai-Ping
authors.initials: KP
authors.lastname: Chen
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Ping-Hsun
authors.initials: PH
authors.lastname: Yang
authors.forename: Gwo-Fang
authors.initials: GF
authors.lastname: Yuan
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D032741:Monascus / Q000737:chemistry*; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D011725:Pyridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D011725:Pyridines; D009569:Nitric Oxide