title: [Change in platelet aggregation and ATP secretion: is there an early prediction of antidepressive therapy? (preliminary report)].
abstract: The number of biomarkers has increased to a great extent in the last years, but we have no marker in practice to help in the diagnosis of depression or to estimate the effectiveness of therapy. In depression we can measure the activation and aggregation of platelets, and the parallel secretion of ATP. Antidepressive therapy decreases aggregation and leads to changes in the release of ATP as well. The aim of our study was to determine whether the change in ATP release in early stages can predict the effectiveness of antidepressive treatment.
authors.affiliation: Honvédkórház-állami Egészségügyi Központ, Pszichiátriai Osztály, Budapest, Hungary. lacipe@freemail.hu
authors.forename: Laszlo
authors.initials: L
authors.lastname: Peter
authors.forename: Katalin
authors.initials: K
authors.lastname: Schweitzer
authors.forename: Gabor
authors.initials: G
authors.lastname: Kovacs
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D000255:Adenosine Triphosphate