title: Structural-functional role of chloride in photosystem II.
abstract: Chloride binding in photosystem II (PSII) is essential for photosynthetic water oxidation. However, the functional roles of chloride and possible binding sites, during oxygen evolution, remain controversial. This paper examines the functions of chloride based on its binding site revealed in the X-ray crystal structure of PSII at 1.9 Å resolution. We find that chloride depletion induces formation of a salt bridge between D2-K317 and D1-D61 that could suppress the transfer of protons to the lumen.
authors.affiliation: Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA. ivan.rivalta@yale.edu
authors.forename: Ivan
authors.initials: I
authors.lastname: Rivalta
authors.forename: Muhamed
authors.initials: M
authors.lastname: Amin
authors.forename: Sandra
authors.initials: S
authors.lastname: Luber
authors.forename: Serguei
authors.initials: S
authors.lastname: Vassiliev
authors.forename: Ravi
authors.initials: R
authors.lastname: Pokhrel
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Umena
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kawakami
authors.forename: Jian-Ren
authors.initials: JR
authors.lastname: Shen
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kamiya
authors.forename: Doug
authors.initials: D
authors.lastname: Bruce
authors.forename: Gary W
authors.initials: GW
authors.lastname: Brudvig
authors.forename: M R
authors.initials: MR
authors.lastname: Gunner
authors.forename: Victor S
authors.initials: VS
authors.lastname: Batista
mesh_terms: D001665:Binding Sites; D002712:Chlorides / Q000737:chemistry* / Q000378:metabolism*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D010100:Oxygen / Q000378:metabolism; D045332:Photosystem II Protein Complex / Q000378:metabolism*; D011522:Protons; D013329:Structure-Activity Relationship
chemical_list: D002712:Chlorides; D045332:Photosystem II Protein Complex; D011522:Protons; D010100:Oxygen