title: The importance of a proper aetiological diagnosis in the management of patients with invasive mycoses: a case report of a brain abscess by Scedosporium apiospermum.
abstract: Scedosporium apiospermum is a saprobic fungus responsible for many different clinical manifestations. Although it affects mostly immunocompromised patients, pulmonary and disseminated scedosporiosis have also been reported in immunocompetent subjects. It often causes subcutaneous mycetoma, despite its preferential tropism to CNS. The authors describe a fatal case of a S. apiospermum brain abscess in a 58-year-old female. She was affected by chronic liver disease and idiopathic pulmonary fibrosis and had been treated with corticosteroid therapy for a long time. She recovered in a neurosurgery unit, wherein TC scan and cerebral MRI revealed an expansive left temporo-parietal process with vasogenic oedema. A stereotactic puncture of the lesion was carried out, and pus of brain abscess was evacuated. Empirical antifungal therapy was initiated with liposomal amphotericine B based on the clinical suspicion of Zygomycetes infection; after 3 days, posaconazole was added. The correct aetiological diagnosis arrived too late and the patient was treated with no specific therapy. This fatal case confirms the necessity of having a fast and correct aetiological diagnosis to improve the patient's outcome.
authors.affiliation: Department of Biomedical Science and Human Oncology-Hygiene Section, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy. caggianog@igiene.uniba.it
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Caggiano
authors.forename: Piero
authors.initials: P
authors.lastname: Cantisani
authors.forename: Marilena
authors.initials: M
authors.lastname: Rolli
authors.forename: Cosimo Damiano
authors.initials: CD
authors.lastname: Gianfreda
authors.forename: Maria
authors.initials: M
authors.lastname: Pizzolante
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Montagna
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects; D000935:Antifungal Agents / Q000008:administration & dosage; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001922:Brain Abscess / Q000175:diagnosis* / Q000382:microbiology* / Q000628:therapy; D004322:Drainage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D008279:Magnetic Resonance Imaging; D009181:Mycoses / Q000175:diagnosis* / Q000628:therapy*; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000382:microbiology* / Q000628:therapy; D021681:Scedosporium / Q000302:isolation & purification*; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure
chemical_list: D000305:Adrenal Cortex Hormones; D000935:Antifungal Agents; D007166:Immunosuppressive Agents