title: Genotyping of human papillomavirus in triaging of low-grade cervical cytology.
abstract: OBJECTIVE
  The objective of the study was to evaluate whether typing of human papillomavirus (HPV) among women with low-grade cervical cytology can improve the ability to identify women with cervical cancer or cervical intraepithelial neoplasia grade III (CIN III or worse).
  
  
  METHODS
  A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of HPV triaging using Hybrid Capture II were also HPV genotyped and CIN III or worse predictive values evaluated.
  
  
  RESULTS
  HPV 16 was detected in 57% of cases with CIN III or worse but only among 24% of all tested women. Testing for the 3 HPV types with highest risk (HPV16/31/33) detected 77% of CIN III or worse, with 36% of women testing positive. Positivity for the other high-risk HPV types had a decreased risk for CIN III or worse.
  
  
  CONCLUSIONS
  Different high-risk HPV types confer different risks for the presence of CIN III or worse, implying that HPV genotyping could be useful for the optimization of triaging strategies.
authors.affiliation: World Health Organization HPV LabNet Global Reference Laboratory, Department of Clinical Microbiology, Skåne University Hospital, Malmö, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Söderlund-Strand
authors.forename: Carina
authors.initials: C
authors.lastname: Eklund
authors.forename: Levent
authors.initials: L
authors.lastname: Kemetli
authors.forename: Lena
authors.initials: L
authors.lastname: Grillner
authors.forename: Sven
authors.initials: S
authors.lastname: Törnberg
authors.forename: Joakim
authors.initials: J
authors.lastname: Dillner
authors.forename: Lena
authors.initials: L
authors.lastname: Dillner
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D016001:Confidence Intervals; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D060005:Genotyping Techniques; D052162:Human papillomavirus 16 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D016015:Logistic Models; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D009367:Neoplasm Staging; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000821:virology*; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000821:virology*