title: An improved synthesis of 'octa-acid' deep-cavity cavitand.
abstract: An improved synthesis of a water-soluble deep-cavity cavitand (octa-acid, 1) is presented. Previously (Gibb, C. L. D. & Gibb, B. C., J. Am. Chem. Soc., 2004, 126, 11408-11409) we documented access to host 1 in eight (non-linear) steps starting from resorcinol; a synthesis that required four steps involving chromatographic purification. Here we reveal a modified synthesis of host 1. Consisting of seven (non-linear) steps, this new synthesis involves only one chromatographic step, and avoids a minor impurity observed in the original approach. This improved synthesis will therefore be useful for the laboratories that are investigating the properties of these types of host.
authors.affiliation: Department of Chemistry, University of New Orleans New Orleans, LA 70148, USA.
authors.forename: Simin
authors.initials: S
authors.lastname: Liu
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Whisenhunt-Ioup
authors.forename: Corinne L D
authors.initials: CL
authors.lastname: Gibb
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Gibb