title: Tissue-specific gene targeting by the multiprotein mammalian DREAM complex.
abstract: The mammalian DP, RB-like, E2F, and MuvB-like proteins (DREAM) complex, whose key components include p130 and E2F4, plays a fundamental role in repression of cell cycle-specific genes during growth arrest. Mammalian DREAM is well conserved with Drosophila and Caenorhabditis elegans complexes that repress pivotal developmental genes, but the mammalian complex has been thought to exist only in quiescent cells and not to be linked with development. However, new findings here identify tissue-specific promoters repressed by DREAM in proliferating precursors, revealing a new connection between control of growth arrest and terminal differentiation. Mechanistically, tissue-specific promoter occupation by DREAM is dependent on the integrity of a repressor form of the SWI/SNF chromatin-remodeling complex.
authors.affiliation: Department of Orthopaedics, New Jersey Medical School-University Hospital Cancer Center, University of Medicine and Dentistry, New Jersey, Newark, New Jersey 07103, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Flowers
authors.forename: George R
authors.initials: GR
authors.lastname: Beck
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Moran
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D020169:Caspases / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D002460:Cell Line; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster; D050704:E2F4 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D051605:Kv Channel-Interacting Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D050717:Retinoblastoma-Like Protein p130 / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D002868:Chromosomal Proteins, Non-Histone; C496756:Csen protein, mouse; D029721:Drosophila Proteins; D050704:E2F4 Transcription Factor; C493763:E2f4 protein, mouse; D051605:Kv Channel-Interacting Proteins; D046912:Multiprotein Complexes; C493838:Rbl2 protein, mouse; D012097:Repressor Proteins; D050717:Retinoblastoma-Like Protein p130; C445179:SWI-SNF-B chromatin-remodeling complex; D014157:Transcription Factors; D020169:Caspases; C438246:STRICA protein, Drosophila