title: Modiolide and pyrone derivatives from the sea fan-derived fungus Curvularia sp. PSU-F22.
abstract: Investigation of secondary metabolites from the sea fan-derived fungus Curvularia sp. PSU-F22 resulted in isolation of three new metabolites, curvulapyrone (1), curvulalide (2) and curvulalic acid (3) together with six known compounds, modiolides A (4) and B (5), pyrenolide A (6), stagonolide E (7), mycoepoxydiene (8), and deacetylmycoepoxydiene (9). Their antimicrobial activity against Staphylococcus aureus ATCC 25923, methicillin-resistant S. aureus and Microsporum gypseum SH-MU-4 were examined.
authors.affiliation: Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand.
authors.forename: Kongkiat
authors.initials: K
authors.lastname: Trisuwan
authors.forename: Vatcharin
authors.initials: V
authors.lastname: Rukachaisirikul
authors.forename: Souwalak
authors.initials: S
authors.lastname: Phongpaichit
authors.forename: Sita
authors.initials: S
authors.lastname: Preedanon
authors.forename: Jariya
authors.initials: J
authors.lastname: Sakayaroj
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000254:growth & development / Q000382:microbiology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D055808:Drug Discovery; D005285:Fermentation; D019156:Indian Ocean; D007536:Isomerism; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013785:Thailand
chemical_list: D000890:Anti-Infective Agents; D007783:Lactones; D018942:Macrolides; D011753:Pyrones