title: 2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus.
abstract: A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin.
authors.affiliation: CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, VIC 3168, Australia.
authors.forename: Abdelselam
authors.initials: A
authors.lastname: Ali
authors.forename: Teresa
authors.initials: T
authors.lastname: Cablewski
authors.forename: Craig L
authors.initials: CL
authors.lastname: Francis
authors.forename: Ashit K
authors.initials: AK
authors.lastname: Ganguly
authors.forename: Roger M
authors.initials: RM
authors.lastname: Sargent
authors.forename: David G
authors.initials: DG
authors.lastname: Sawutz
authors.forename: Kevin N
authors.initials: KN
authors.lastname: Winzenberg
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006189:Haemonchus / Q000187:drug effects* / Q000254:growth & development; D007559:Ivermectin / Q000737:chemistry / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000969:Antinematodal Agents; D011724:Pyridazines; C062482:pyridazine; D007559:Ivermectin