title: Inhibitory effect of a hot water extract of coffee "silverskin" on hyaluronidase.
abstract: Coffee "silverskin" (CS) is a by-product of the roasting procedure for coffee beans. A CS extract (CS-ext) was found to have a high inhibitory effect against hyaluronidase. It seems that the higher-molecular-weight substances in CS-ext contributed most to the hyaluronidase inhibition, while acidic polysaccharides mainly composed of uronic acid played a major role in this hyaluronidase inhibition by CS-ext.
authors.affiliation: R&D Center, UCC Ueshima Coffee Co., Ltd., Takatsuki, Osaka, Japan.
authors.forename: Mina
authors.initials: M
authors.lastname: Furusawa
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Narita
authors.forename: Kazuya
authors.initials: K
authors.lastname: Iwai
authors.forename: Taiji
authors.initials: T
authors.lastname: Fukunaga
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakagiri
mesh_terms: D000143:Acids / Q000737:chemistry; D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000627:therapeutic use; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D003069:Coffee / Q000737:chemistry*; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D006358:Hot Temperature; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006967:Hypersensitivity / Q000188:drug therapy; D020128:Inhibitory Concentration 50; D008970:Molecular Weight; D009005:Monosaccharides / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology; D014574:Uronic Acids / Q000737:chemistry / Q000494:pharmacology; D014867:Water
chemical_list: D000143:Acids; D018926:Anti-Allergic Agents; D003069:Coffee; D004791:Enzyme Inhibitors; D009005:Monosaccharides; D010936:Plant Extracts; D011134:Polysaccharides; D014574:Uronic Acids; D014867:Water; D006821:Hyaluronoglucosaminidase