title: Efficient assembly of multi-walled carbon nanotube-CdSe/ZnS quantum dot hybrids with high biocompatibility and fluorescence property.
abstract: CdSe/ZnS core-shell quantum dots (QDs) were efficiently tethered onto polyamidoamine dendrimer-modified multi-walled carbon nanotubes (MWCNTs) by covalent linkage and mercapto-mediated assembly. The obtained MWCNT-QD hybrids were both photophysically and morphologically characterized. The QDs are well-distributed on single nanotube surface in high density and the assembly of QDs onto MWCNTs does not change the fluorescence emission wavelength of QDs but significantly decreases the emission density. Cytotoxicity of MWCNT-QD hybrids to HeLa cells and their fluorescence property in living cell system were evaluated in detail. The hybrids show a little effect on cell viability even at very high concentration (100 μg mL(-1)). Moreover, they possess intense red fluorescence signal under optical fluorescence microscopy and good fluorescence stability over 72-h exposure in living cell system.
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, PR China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Weiling
authors.initials: W
authors.lastname: Qin
authors.forename: Hao
authors.initials: H
authors.lastname: Tang
authors.forename: Feng
authors.initials: F
authors.lastname: Yan
authors.forename: Liang
authors.initials: L
authors.lastname: Tan
authors.forename: Qingji
authors.initials: Q
authors.lastname: Xie
authors.forename: Ming
authors.initials: M
authors.lastname: Ma
authors.forename: Youyu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shouzhuo
authors.initials: S
authors.lastname: Yao
mesh_terms: D001672:Biocompatible Materials / Q000032:analysis / Q000138:chemical synthesis / Q000494:pharmacology; D002104:Cadmium; D002244:Carbon; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers / Q000032:analysis / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D037742:Nanotubes, Carbon / Q000032:analysis / Q000737:chemistry*; D045663:Quantum Dots; D012643:Selenium; D013050:Spectrometry, Fluorescence; D013440:Sulfides; D017967:Zinc Compounds
chemical_list: D001672:Biocompatible Materials; D050091:Dendrimers; D037742:Nanotubes, Carbon; C104700:PAMAM Starburst; D013440:Sulfides; D017967:Zinc Compounds; D002104:Cadmium; D002244:Carbon; D012643:Selenium; C031238:zinc sulfide