title: Synthesis and screening of galactose-linked nitroimidazoles and triazoles against Mycobacterium tuberculosis.
abstract: A series of galactose-linked nitroimidazoles/triazoles were synthesised and screened against Mycobacterium tuberculosis H(37)Rv. Preliminary results were promising with MIC values in the range 1.56-12.5 μg/mL. Most importantly they are active under aerobic condition under which metronidazole is inactive.
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab 160062, India.
authors.forename: G
authors.initials: G
authors.lastname: Mugunthan
authors.forename: Kuppala
authors.initials: K
authors.lastname: Ramakrishna
authors.forename: Dharmarajan
authors.initials: D
authors.lastname: Sriram
authors.forename: Perumal
authors.initials: P
authors.lastname: Yogeeswari
authors.forename: K P
authors.initials: KP
authors.lastname: Ravindranathan Kartha
mesh_terms: D005690:Galactose / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D009593:Nitroimidazoles; D014230:Triazoles; D005690:Galactose