title: Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium.
abstract: The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium (OCAC). All participants were non-Hispanic white women. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression adjusted for site and age. Women with the TT genotype were at increased risk of ovarian carcinoma compared to carriers of the G allele (OR = 1.10; 95%; CI: 1.01-1.21; p = 0.04); the OR was 1.09 (CI: 0.99-1.20; p = 0.07) after excluding data from the center (Hawaii) that nominated this SNP for OCAC genotyping A stronger association of rs1271572 TT versus GT/GG with risk was observed among women aged ≤50 years versus older women (OR = 1.35; CI: 1.12-1.62; p = 0.002; p for interaction = 0.02) that remained statistically significant after excluding Hawaii data (OR = 1.34; CI: 1.11-1.61; p = 0.009). No heterogeneity of the association was observed by study, menopausal status, gravidity, parity, use of contraceptive or menopausal hormones, tumor histological type, or stage at diagnosis. This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women.
authors.affiliation: Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America. GLurie@crch.hawaii.edu
authors.forename: Galina
authors.initials: G
authors.lastname: Lurie
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Thompson
authors.forename: Yurii B
authors.initials: YB
authors.lastname: Shvetsov
authors.forename: Rayna K
authors.initials: RK
authors.lastname: Matsuno
authors.forename: Michael E
authors.initials: ME
authors.lastname: Carney
authors.forename: Rachel T
authors.initials: RT
authors.lastname: Palmieri
authors.forename: Anna H
authors.initials: AH
authors.lastname: Wu
authors.forename: Malcolm C
authors.initials: MC
authors.lastname: Pike
authors.forename: Celeste L
authors.initials: CL
authors.lastname: Pearce
authors.forename: Usha
authors.initials: U
authors.lastname: Menon
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Gentry-Maharaj
authors.forename: Simon A
authors.initials: SA
authors.lastname: Gayther
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Ramus
authors.forename: Alice S
authors.initials: AS
authors.lastname: Whittemore
authors.forename: Valerie
authors.initials: V
authors.lastname: McGuire
authors.forename: Weiva
authors.initials: W
authors.lastname: Sieh
authors.forename: Paul D P
authors.initials: PD
authors.lastname: Pharoah
authors.forename: Honglin
authors.initials: H
authors.lastname: Song
authors.forename: Jacek
authors.initials: J
authors.lastname: Gronwald
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.forename: Cezary
authors.initials: C
authors.lastname: Cybulski
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
authors.forename: Joellen M
authors.initials: JM
authors.lastname: Schildkraut
authors.forename: Andrew
authors.initials: A
authors.lastname: Berchuck
authors.forename: Susanne
authors.initials: S
authors.lastname: Krüger Kjær
authors.forename: Estrid
authors.initials: E
authors.lastname: Høgdall
authors.forename: Peter A
authors.initials: PA
authors.lastname: Fasching
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Beckmann
authors.forename: Arif B
authors.initials: AB
authors.lastname: Ekici
authors.forename: Alexander
authors.initials: A
authors.lastname: Hein
authors.forename: Georgia
authors.initials: G
authors.lastname: Chenevix-Trench
authors.forename: Penelope M
authors.initials: PM
authors.lastname: Webb
authors.forename: Jonathan
authors.initials: J
authors.lastname: Beesley
authors.forename: Marc T
authors.initials: MT
authors.lastname: Goodman
mesh_terms: D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012958:Societies, Scientific
chemical_list: D047629:Estrogen Receptor beta