title: Important role of oxidative stress biomarkers in Huntington's disease.
abstract: This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Universidad de Córdoba, Córdoba, Spain. fm2tufii@uco.es
authors.forename: Isaac
authors.initials: I
authors.lastname: Túnez
authors.forename: Fernando
authors.initials: F
authors.lastname: Sánchez-López
authors.forename: Eduardo
authors.initials: E
authors.lastname: Agüera
authors.forename: Ricardo
authors.initials: R
authors.lastname: Fernández-Bolaños
authors.forename: Francisco Manuel
authors.initials: FM
authors.lastname: Sánchez
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Tasset-Cuevas
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D050050:Protein Carbonylation
chemical_list: D000975:Antioxidants; D015415:Biomarkers