title: Large eddy simulation of a stenosed artery using a femoral artery pulsatile flow profile.
abstract: Computational fluid dynamics simulation of stenosed arteries allows the analysis of quantities including wall shear stress, velocity, and pressure; detailed in vivo measurement is difficult yet the analysis of the fluid dynamics related to stenosis is important in understanding the likely causes and ongoing effects on the integrity of the vessel. In this study, a three-dimensional Large Eddy Simulation is conducted of a 50% occluded vessel, with a typical femoral artery profile used as the transient inlet conditions. The fluid is assumed to be homogenous, Newtonian and incompressible and the walls are assumed rigid. The stenosis is axisymmetric, however the three-dimensional study allows for a flow field that is not axisymmetric and results show significant three-dimensionality. High values of wall shear stress and oscillatory values of wall shear stress (varying in both space time) are observed. The results of the study give insight into the time-varying flow structures for a mildly stenosed artery and indicate that three-dimensional simulations may be important to gain a complete understanding of the flow field.
authors.affiliation: School of Mechanical & Manufacturing Engineering, University of New South Wales, Sydney, NSW, Australia. t.barber@unsw.edu.au
authors.forename: Tracie J
authors.initials: TJ
authors.lastname: Barber
authors.forename: Anne
authors.initials: A
authors.lastname: Simmons
mesh_terms: D003198:Computer Simulation; D003251:Constriction, Pathologic / Q000473:pathology / Q000503:physiopathology*; D004548:Elasticity; D005263:Femoral Artery / Q000473:pathology / Q000503:physiopathology*; D018056:Hemorheology; D006801:Humans; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D013314:Stress, Mechanical