title: [Radiation biology: major advances and perspectives for radiotherapy].
abstract: At the beginning of the 21st century, radiation biology is at a major turning point in its history. It must meet the expectations of the radiation oncologists, radiologists and the general public, but its purpose remains the same: to understand the molecular, cellular and tissue levels of lethal and carcinogenic effects of ionizing radiation in order to better protect healthy tissues and to develop treatments more effective against tumours. Four major aspects of radiobiology that marked this decade will be discussed: technological developments, the importance of signalling and repair of radiation-induced deoxyribonucleic acid (DNA) damage, the impact of individual factor in the response to radiation and the contribution of radiobiology to better choose innovative therapies such as protontherapy or stereotactic body radiation therapy (SBRT). A translational radiobiology should emerge with the help of radiotherapists and radiation physicists and by facilitating access to the new radio and/or chemotherapy modalities.
authors.affiliation: Société Magelis, lotissement Bel-Air, 6 rue Frédéric-Mistral, Cadenet, France.
authors.forename: A
authors.initials: A
authors.lastname: Joubert
authors.forename: G
authors.initials: G
authors.lastname: Vogin
authors.forename: C
authors.initials: C
authors.lastname: Devic
authors.forename: A
authors.initials: A
authors.lastname: Granzotto
authors.forename: M
authors.initials: M
authors.lastname: Viau
authors.forename: M
authors.initials: M
authors.lastname: Maalouf
authors.forename: C
authors.initials: C
authors.lastname: Thomas
authors.forename: C
authors.initials: C
authors.lastname: Colin
authors.forename: N
authors.initials: N
authors.lastname: Foray
mesh_terms: D004247:DNA / Q000528:radiation effects; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D005544:Forecasting; D006283:Health Physics; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D018787:Radiation Oncology / Q000639:trends; D011836:Radiation Tolerance / Q000235:genetics; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D011853:Radiobiology / Q000639:trends*; D016634:Radiosurgery; D011878:Radiotherapy / Q000379:methods / Q000639:trends*; D015398:Signal Transduction / Q000187:drug effects; D013679:Technology, Radiologic; D035703:Therapies, Investigational; D057170:Translational Research, Biomedical
chemical_list: D011838:Radiation-Sensitizing Agents; D004247:DNA