title: Thiourea isosteres as anion receptors and transmembrane transporters.
abstract: Compounds containing cyanoguanidine and 3-amino-1,2,4-benzothiadiazine-1,1-dioxide have been studied as anion receptors and transporters. Significant affinity for oxo-anions was observed in organic solution and the receptors were found to function as transmembrane chloride/nitrate antiporters with transport rates enhanced in the presence of valinomycin-K(+) complex.
authors.affiliation: Chemistry, University of Southampton, Southampton, SO17 1BJ, UK.
authors.forename: Marco
authors.initials: M
authors.lastname: Wenzel
authors.forename: Mark E
authors.initials: ME
authors.lastname: Light
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Davis
authors.forename: Philip A
authors.initials: PA
authors.lastname: Gale
mesh_terms: D027321:Anion Transport Proteins / Q000737:chemistry / Q000378:metabolism*; D000838:Anions / Q000378:metabolism*; D017920:Antiporters / Q000737:chemistry / Q000378:metabolism*; D001581:Benzothiadiazines / Q000737:chemistry / Q000378:metabolism; D002463:Cell Membrane Permeability; D003499:Cyclic S-Oxides / Q000737:chemistry / Q000378:metabolism; D006146:Guanidines / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D010713:Phosphatidylcholines / Q000378:metabolism; D013890:Thiourea / Q000031:analogs & derivatives* / Q000378:metabolism*; D053835:Unilamellar Liposomes / Q000378:metabolism; D014634:Valinomycin / Q000378:metabolism
chemical_list: D027321:Anion Transport Proteins; D000838:Anions; D017920:Antiporters; D001581:Benzothiadiazines; D003499:Cyclic S-Oxides; D006146:Guanidines; D010713:Phosphatidylcholines; D053835:Unilamellar Liposomes; D014634:Valinomycin; D013890:Thiourea; C004711:dicyandiamido; C028694:1-palmitoyl-2-oleoylphosphatidylcholine