title: Mimicking heme enzymes in the solid state: metal-organic materials with selectively encapsulated heme.
abstract: To carry out essential life processes, nature has had to evolve heme enzymes capable of synthesizing and manipulating complex molecules. These proteins perform a plethora of chemical reactions utilizing a single iron porphyrin active site embedded within an evolutionarily designed protein pocket. We herein report the first class of metal-organic materials (MOMs) that mimic heme enzymes in terms of both structure and reactivity. The MOMzyme-1 class is based upon a prototypal MOM, HKUST-1, into which catalytically active metalloporphyrins are selectively encapsulated in a "ship-in-a-bottle" fashion within one of the three nanoscale cages that exist in HKUST-1. MOMs offer unparalleled levels of permanent porosity and their modular nature affords enormous diversity of structures and properties. The MOMzyme-1 class could therefore represent a new paradigm for heme biomimetic catalysis since it combines the activity of a homogeneous catalyst with the stability and recyclability of heterogeneous catalytic systems within a single material.
authors.affiliation: Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, USA. rwlarsen@usf.edu
authors.forename: Randy W
authors.initials: RW
authors.lastname: Larsen
authors.forename: Lukasz
authors.initials: L
authors.lastname: Wojtas
authors.forename: Jason
authors.initials: J
authors.lastname: Perman
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Musselman
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Zaworotko
authors.forename: Carissa M
authors.initials: CM
authors.lastname: Vetromile
mesh_terms: D000818:Animals; D004798:Enzymes / Q000737:chemistry*; D006418:Heme / Q000737:chemistry*; D000073396:Metal-Organic Frameworks; D008665:Metalloporphyrins / Q000737:chemistry; D018716:Molecular Mimicry; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D004798:Enzymes; D000073396:Metal-Organic Frameworks; D008665:Metalloporphyrins; D009942:Organometallic Compounds; C539834:bis(1,3,5-benzenetricarboxylate)tricopper(II); D006418:Heme