title: First report of the bla(OXA-58) gene in a clinical isolate of Acinetobacter baumannii in Rio de Janeiro, Brazil.
abstract: Carbapenemase production is an important mechanism of carbapenem resistance among nonfermentative Gram-negative isolates. This study aimed to report the detection of bla(OXA-58) gene in multiresistant clinical isolates of Acinetobacter baumannii recovered from inpatients in a public hospital. Polymerase chain reaction tests were performed to detect the bla(OXA-23-like), bla(OXA-24-like), bla(OXA-58-like) and bla(OXA-51-like) genes. The bla(OXA-58) and bla(OXA-23) genes were detected in one and three isolates, respectively. Sequencing of the bla(OXA-58-like) amplicon revealed 100% identity with the A. baumannii bla(OXA-58) gene listed in the GenBank database. This is the first report of an OXA-58-producing A. baumannii isolate in Rio de Janeiro, Brazil.
authors.affiliation: Programa de Pós-Graduação em Patologia Clínica, Universidade Federal Fluminense, Niterói, RJ, Brasil.
authors.forename: Deuseli Quaresma de
authors.initials: DQ
authors.lastname: Figueiredo
authors.forename: Kátia Regina Netto Dos
authors.initials: KR
authors.lastname: Santos
authors.forename: Eliezer Menezes
authors.initials: EM
authors.lastname: Pereira
authors.forename: Ricardo Pinto
authors.initials: RP
authors.lastname: Schuenck
authors.forename: Cláudia Rezende Vieira de
authors.initials: CR
authors.lastname: Mendonça-Souza
authors.forename: Lúcia Martins
authors.initials: LM
authors.lastname: Teixeira
authors.forename: Silvia Susana Bona de
authors.initials: SS
authors.lastname: Mondino
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C534889:beta-lactamase OXA-58, Acinetobacter baumannii