title: A heparin-coated dialysis filter (AN69 ST) does not reduce clotting during hemodialysis when compared to a conventional polysulfone filter (F×8).
abstract: BACKGROUND
  We investigated whether the heparin-coated AN69 ST hemodialysis (HD) filter induced less hypercoagulability during HD than a conventional polysulfone filter (F×8).
  
  
  METHODS
  In a crossover design, 11 patients were treated alternately with AN69 ST and F×8 filters (45 sessions). All filters were primed with unfractionated heparin (UFH) and unadsorbed UFH was removed by saline flushing. Half the conventional dalteparin dose was given as a bolus dose at the start of HD. Clotting was evaluated hourly in the venous air trap. Prothrombin fragments 1 and 2 (PF1 + 2), antithrombin (AT), β-TG and anti-FXa activity were repeatedly measured.
  
  
  RESULTS
  One patient treated with enalapril had two repeated adverse reactions to the AN69 ST filter and was excluded from the study. Use of the AN69 ST filter did not decrease the mean clot score or PF1 + 2, but decreased β-TG compared to the F×8 filter.
  
  
  CONCLUSIONS
  The heparin-coated AN69 ST filter did not induce less coagulation when compared to the F×8 filter.
authors.affiliation: Department of Nephrology, Oslo University Hospital Ullevål, Oslo, Norway.
authors.forename: Solbjørg
authors.initials: S
authors.lastname: Sagedal
authors.forename: Bartlomiej J
authors.initials: BJ
authors.lastname: Witczak
authors.forename: Kåre
authors.initials: K
authors.lastname: Osnes
authors.forename: Anders
authors.initials: A
authors.lastname: Hartmann
authors.forename: Ingrid
authors.initials: I
authors.lastname: Os
authors.forename: Lars
authors.initials: L
authors.lastname: Eikvar
authors.forename: Olav
authors.initials: O
authors.lastname: Klingenberg
authors.forename: Frank
authors.initials: F
authors.lastname: Brosstad
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D020099:Coated Materials, Biocompatible; D018592:Cross-Over Studies; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D006435:Renal Dialysis / Q000295:instrumentation* / Q000379:methods; D013450:Sulfones
chemical_list: D000925:Anticoagulants; D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D006493:Heparin