title: Allergic inflammation: role of cytokines with special emphasis on IL-4.
abstract: This review examines recent articles on the relationship of cytokines to allergy and inflammation with particular emphasis on interleukin (IL)-4. The objective of this article is therefore to review published studies to identify cytokines consistently involved in allergic inflammation. Proinflammatory cytokines, including IL-4, IL-5, IL-13 and GM-CSF along with TNF-alpha play a role in allergen-induced airway leukocyte recruitment and these cytokines can be generated by T mast cells and other cells. In addition, IL-9, IL-25, IL-33, IL-17, IL-27 and IFN-gamma are deeply involved in the regulation of asthma. Blocking the effect of these proinflammatory cytokines might provide new therapeutic approaches for the control of allergy and inflammation.
authors.forename: A
authors.initials: A
authors.lastname: Saggini
authors.forename: G
authors.initials: G
authors.lastname: Maccauro
authors.forename: D
authors.initials: D
authors.lastname: Tripodi
authors.forename: M A
authors.initials: MA
authors.lastname: De Lutiis
authors.forename: F
authors.initials: F
authors.lastname: Conti
authors.forename: P
authors.initials: P
authors.lastname: Felaco
authors.forename: M
authors.initials: M
authors.lastname: Fulcheri
authors.forename: R
authors.initials: R
authors.lastname: Galzio
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.forename: M
authors.initials: M
authors.lastname: Felaco
authors.forename: F
authors.initials: F
authors.lastname: Pandolfi
authors.forename: G
authors.initials: G
authors.lastname: Sabatino
authors.forename: G
authors.initials: G
authors.lastname: Neri
authors.forename: Y B
authors.initials: YB
authors.lastname: Shaik-Dasthagirisaheb
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D015847:Interleukin-4