title: Dementia associated with Parkinson's disease: applying the Movement Disorder Society Task Force criteria.
abstract: BACKGROUND
  Diagnostic criteria and procedures for dementia in Parkinson's disease (PDD) have been proposed by a Movement Disorders Society Task Force (MDS-TF). The objective of this study was to explore the utility of the new MDS-TF criteria and procedures in clinical practice.
  
  
  METHODS
  Two hundred ninety nine PD patients (36.5% with PDD as per MDFS-TF criteria; 33.1% according the DSM-IV) were included in the study. A variety of standardized motor, cognitive, psychiatric, and global severity measures were administered. A multivariate logistic regression model was built to determine the variables producing discrepancy between the MDS-TF and DSM-IV criteria for PDD and the clinical features that distinguished false negative cases.
  
  
  RESULTS
  Agreement between MDS-TF and DSM-IV criteria was substantial (87.3%; kappa = 0.72), but the DSM-IV criteria failed to identify 22% of patients fulfilling MDS-TF criteria. False negative cases were older and had more severe motor symptoms but less psychosis than those true non-demented PD. False positives had less severe motor symptoms than true PDD, although the difference did not reach statistical significance.
  
  
  CONCLUSIONS
  Our findings suggest that the MDS-TF criteria are more sensitive than the DSM-IV for a diagnosis of PDD. Old age, absence of psychiatric symptoms, and severe motor impairment can hinder the diagnosis of PDD.
authors.affiliation: Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain. pmartinez@isciii.es
authors.forename: P
authors.initials: P
authors.lastname: Martinez-Martin
authors.forename: C
authors.initials: C
authors.lastname: Falup-Pecurariu
authors.forename: C
authors.initials: C
authors.lastname: Rodriguez-Blazquez
authors.forename: M
authors.initials: M
authors.lastname: Serrano-Dueñas
authors.forename: F J
authors.initials: FJ
authors.lastname: Carod Artal
authors.forename: J M
authors.initials: JM
authors.lastname: Rojo Abuin
authors.forename: D
authors.initials: D
authors.lastname: Aarsland
mesh_terms: D026683:Advisory Committees / Q000592:standards*; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003704:Dementia / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D038622:Internationality; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D010300:Parkinson Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D012955:Societies, Medical / Q000592:standards*