title: [Screening of Tag SNPs and prediction of their potential function in genetic studies of complex diseases].
abstract: We applied public databases of single nucleotide polymorphism (SNP) to screen complex disease-related SNPs and assessed the potential functions of selected SNPs through SNP function prediction software, including FastSNP, SNP Function Prediction, F-SNP. We selected Tag SNP in HapMap database and compared all results with above software. With above strategies we screened IGFBP7 gene and obtained total 47 SNPs, including 11 TFBS SNPs, 31 intronic enhancer SNPs, 4 intronic enhancer and TFBS SNPs and 1 splicing sites SNPs.
authors.affiliation: Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310058, China. zhuym@zju.edu.cn
authors.forename: Yi-min
authors.initials: YM
authors.lastname: Zhu
authors.forename: Yu-yang
authors.initials: YY
authors.lastname: Xu
authors.forename: Jie
authors.initials: J
authors.lastname: Ling
mesh_terms: D030541:Databases, Genetic; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012984:Software
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; C102529:insulin-like growth factor binding protein-related protein 1