title: [Separation of bases, phenols and pharmaceuticals on ionic liquid-modified silica stationary phase with pure water as mobile phase].
abstract: N-methylimidazolium ionic liquid (IL) -modified silica was prepared with the reaction of 3-chloropropyl modified silica and N-methylimidazole using toluene as solvent. Based on the multiple interactions between N-methylimidazolium IL-modified silica and analytes such as hydrophobic interaction, electrostatic attraction, repulsion interaction, hydrogen-bonding, etc., the bases (cytosine, thymine, 2-aminopyrimidine and 6-chloroguanine), phenols (m-aminophenol, resorcinol and m-nitrophenol) and three pharmaceuticals (moroxydine hydrochloride, acyclovir and cephalexin hydrate) were separated successfully with only pure water as the mobile phase. These chromatographic separations are environmental friendly, economical and convenient, without any organic solvent or buffer additive. The retention mechanism of these samples on the stationary phase was also investigated.
authors.affiliation: Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
authors.forename: Xusheng
authors.initials: X
authors.lastname: Wang
authors.forename: Hongdeng
authors.initials: H
authors.lastname: Qiu
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.forename: Shengxiang
authors.initials: S
authors.lastname: Jiang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D003596:Cytosine / Q000302:isolation & purification*; D052578:Ionic Liquids / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000302:isolation & purification*; D010636:Phenols / Q000302:isolation & purification*; D011743:Pyrimidines / Q000302:isolation & purification; D012822:Silicon Dioxide / Q000737:chemistry; D013941:Thymine / Q000302:isolation & purification; D014867:Water
chemical_list: D052578:Ionic Liquids; D004364:Pharmaceutical Preparations; D010636:Phenols; D011743:Pyrimidines; D014867:Water; C012180:2-aminopyrimidine; D012822:Silicon Dioxide; D003596:Cytosine; D013941:Thymine