title: [Quantification of fluorescein angiography in patients with non-arteritic anterior ischemic optic neuropathy].
abstract: OBJECTIVE
  The aim of this study was to evaluate the retinal hemodynamics and optic disc leakage by fluorescein angiography in patients with non-arteritic anterior ischemic optic neuropathy (NAION) and to correlate fluorescein angiography findings with the extent and topography of visual field loss.
  
  
  METHODS
  A total of 26 patients with acute NAION were included in the study. Fluorescein angiograms were performed by means of a scanning laser ophthalmoscope. The extent of early-phase optic disc leakage was assessed using a semiquantitative approach (focal versus diffuse type of leakage). Retinal arteriovenous passage (AVP) times were measured using dye dilution curves and digital image analysis for each hemisphere. The number of defective visual field points (StatPac: p<0.5%, uncorrected deviation plot) were evaluated (30/2 SITA, Humphrey-Zeiss) for the hemifields and different sectors.
  
  
  RESULTS
  In this study of patients with NAION the mean AVP was 1.79 s±0.43 which was not significantly correlated to the number of defective points. Furthermore, AVP was not significantly different in focal versus diffuse optic disc leakage. The number of defective points were not significantly different in focal versus diffuse leakage of the optic disc (p=0.57).
  
  
  CONCLUSIONS
  Retinal perfusion is not linked to the type and topography of disc leakage or the extent and topography of visual field damage in NAION. A global circulatory disorder e.g. due to a compartment syndrome of the optic nerve might account for these results.
authors.affiliation: Augenklinik des Universitätsklinikum Aachen, Aachen, Deutschland. Thalia.hirsch@gmail.com
authors.forename: T
authors.initials: T
authors.lastname: Hirsch
authors.forename: A
authors.initials: A
authors.lastname: Remky
authors.forename: N
authors.initials: N
authors.lastname: Plange
authors.forename: M
authors.initials: M
authors.lastname: Kaup
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000503:physiopathology; D015897:Comorbidity; D004395:Dye Dilution Technique; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis* / Q000503:physiopathology*; D010211:Papilledema / Q000175:diagnosis / Q000503:physiopathology; D012016:Reference Values; D012171:Retinal Vessels / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D013223:Statistics as Topic; D014794:Visual Fields / Q000502:physiology