title: Interventions for Mooren's ulcer.
abstract: BACKGROUND
  Mooren's ulcer is a chronic, painful peripheral ulcer of the cornea. Its cause is unknown but it can or will lead to loss of vision if untreated. Severe pain is common in patients with Mooren's ulcer and the eye(s) may be intensely reddened, inflamed and photophobic, with tearing. The disease is rare in the northern hemisphere but more common in southern and central Africa, China and the Indian subcontinent. There are a number of treatments used such as anti-inflammatory drugs (steroidal and non-steroidal), cytotoxic drugs (topical and systemic), conjunctivectomy and cornea debridement (superficial keratectomy). There is no evidence to show which is the most effective amongst these treatment modalities.
  
  
  OBJECTIVE
  The aim of this systematic review is to assess the effectiveness of the various interventions (medical and surgical) for Mooren's ulcer.
  
  
  METHODS
  We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2011, Issue 4), MEDLINE (January 1950 to April 2011), EMBASE (January 1980 to April 2011), Latin American and Caribbean Health Sciences Literature Database (LILACS), (January 1982 to April 2011), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com) and ClinicalTrials.gov (www.clinicaltrial.gov). There were no language or date restrictions in the search for trials. The electronic databases were last searched on 16 April 2011.
  
  
  METHODS
  We planned to include randomised controlled trials (RCTs) or discuss any prospective non-RCTs in the absence of any RCTs. The trials included would be of people of any age or gender diagnosed with Mooren's ulcer and all interventions (medical and surgical) would be considered.
  
  
  METHODS
  Two authors screened the search results independently; we found no studies that met our inclusion criteria.
  
  
  RESULTS
  As we found no studies that met our inclusion criteria, we highlighted important considerations for conducting RCTs in the future in this area.
  
  
  CONCLUSIONS
  We found no evidence in the form of RCTs to assess the treatment effect for the various interventions for Mooren's ulcer. High quality RCTs that compare medical or surgical interventions across different demographics are needed. Such studies should make use of various outcome measures, (i.e. healed versus not healed, percentage of area healed, speed of healing etc.) as well as ensuring high quality randomisation and data analysis, as highlighted in this review .
authors.affiliation: Clinical Ophthalmology, The National Eye Centre, Western Bye Pass, Nnamdi Azikiwe Way, Kaduna, Kaduna State, Nigeria, PMP 2267.
authors.forename: Mahmoud B
authors.initials: MB
authors.lastname: Alhassan
authors.forename: Mansur
authors.initials: M
authors.lastname: Rabiu
authors.forename: Idris O
authors.initials: IO
authors.lastname: Agbabiaka
mesh_terms: D003320:Corneal Ulcer / Q000628:therapy*; D006801:Humans