title: [Antioxidant and membranoprotector treatment of chronic pyelonephritis].
abstract: The results of investigation of the clinical efficiency of using the antioxidant drug cytoflavin in a complex therapy of patients with chronic pyelonephritis prior to development of azotemia are presented. It is shown that cytoflavin in combination with basic therapy reduces the intensity of lipid peroxidation processes (as monitored using diene conjugates, malonic dialdehyde, and Schiffbase metabolites) with retention of the antioxidant status. The proposed treatment normalizes the ratio of blood plasma phospholipid fractions and erythrocytes membranes.
authors.forename: I V
authors.initials: IV
authors.lastname: Gordiushina
authors.forename: R P
authors.initials: RP
authors.lastname: Savchenko
authors.forename: D S
authors.initials: DS
authors.lastname: Sukhanov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Petrov
authors.forename: M G
authors.initials: MG
authors.lastname: Romantsov
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D053099:Azotemia / Q000517:prevention & control; D002908:Chronic Disease; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005486:Flavin Mononucleotide / Q000494:pharmacology*; D006801:Humans; D007290:Inosine Diphosphate / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000494:pharmacology*; D010743:Phospholipids / Q000097:blood; D011704:Pyelonephritis / Q000188:drug therapy / Q000378:metabolism; D013386:Succinates / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D008054:Lipid Peroxides; D010743:Phospholipids; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate