title: Thiadiazine derivatives as antiprotozoal new drugs.
abstract: The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities. How the chemical nature of N-substituents influences the overall activity / cytotoxicity profile will also be discussed.
authors.affiliation: Laboratorio de Síntesis Orgánica. Facultad de Quimica, Universidad de La Habana 10400-Ciudad Habana, Cuba;
authors.forename: Julieta Coro
authors.initials: JC
authors.lastname: Bermello
authors.forename: Rolando Pérez
authors.initials: RP
authors.lastname: Piñeiro
authors.forename: Lianet Monzote
authors.initials: LM
authors.lastname: Fidalgo
authors.forename: Hortensia Rodríguez
authors.initials: HR
authors.lastname: Cabrera
authors.forename: Margarita Suárez
authors.initials: MS
authors.lastname: Navarro