title: Atopic dermatitis-like pre-Sézary syndrome: role of immunosuppression.
abstract: We describe here 4 patients with Sézary syndrome masquerading as adult-onset atopic dermatitis. The patients presented with a clinical picture compatible with wide-spread atopic dermatitis and did not fulfil the criteria for Sézary syndrome (lack of lymphoadenopathy and blood involvement, skin histology without presence of atypical cells). In our patients, overt Sézary syndrome developed after immunosuppressive treatment (including cyclosporine). These cases support the validity of the concept of pre-Sézary syndrome, which is a long-lasting, pre-malignant condition, and which may develop to true malignancy in a state of immunosuppression.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Poland. mwojd@gumed.edu.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sokołowska-Wojdyło
authors.forename: Wioletta
authors.initials: W
authors.lastname: Barańska-Rybak
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Cegielska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Trzeciak
authors.forename: Hanna
authors.initials: H
authors.lastname: Lugowska-Umer
authors.forename: Robert
authors.initials: R
authors.lastname: Gniadecki
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D016572:Cyclosporine / Q000009:adverse effects*; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D011237:Predictive Value of Tests; D012751:Sezary Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine