title: Levels of HTNV-specific CD8+ T lymphocytes in PBMC from the patients with hemorrhagic fever with renal syndrome.
abstract: The pathogenesis of hemorrhagic fever with renal syndrome (HFRS) has not been fully clarified. Cell-mediated immunity appears to play a crucial role in the immune pathogenesis of HFRS. To explore the relationship between Hantaan (HTNV)-specific CD8(+) T lymphocytes and the immune pathogenesis of HFRS, the levels of interferon γ (IFN-γ) secreted by HTNV-specific CD8(+) T lymphocytes were detected by flow cytometry in peripheral blood mononuclear cells. Levels of HTNV-specific CD8(+) T lymphocytes in patients with HFRS were associated with different phases of HFRS. In fever phase, it was significantly elevated. The levels of HTNV-specific CD8(+) T lymphocytes in PBMC of patients with HFRS were negatively correlated with the levels of blood urea nitrogen and creatinine in plasma. The results show that the HTNV-specific CD8(+) T lymphocyte levels correlate with disease phases. Therefore, dynamic observation of these levels in patients with HFRS can help to judge the status of HFRS disease and to clarify the immune pathogenesis of HFRS.
authors.affiliation: Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, Xi'an, 710061, China. xieming@mail.xjtu.edu.cn
authors.forename: Ming
authors.initials: M
authors.lastname: Xie
authors.forename: Yanying
authors.initials: Y
authors.lastname: Dong
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Huixun
authors.initials: H
authors.lastname: Ren
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Ji
authors.forename: Shemin
authors.initials: S
authors.lastname: Lv
mesh_terms: D000328:Adult; D000368:Aged; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D005260:Female; D018063:Hantaan virus; D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology* / Q000821:virology; D006801:Humans; D007371:Interferon-gamma / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: C573415:IFNG protein, human; D007371:Interferon-gamma