title: Towards mild metal-catalyzed C-H bond activation.
abstract: Functionalizing traditionally inert carbon-hydrogen bonds represents a powerful transformation in organic synthesis, providing new entries to valuable structural motifs and improving the overall synthetic efficiency. C-H bond activation, however, often necessitates harsh reaction conditions that result in functional group incompatibilities and limited substrate scope. An understanding of the reaction mechanism and rational design of experimental conditions have led to significant improvement in both selectivity and applicability. This critical review summarizes and discusses endeavours towards the development of mild C-H activation methods and wishes to trigger more research towards this goal. In addition, we examine select examples in complex natural product synthesis to demonstrate the synthetic utility of mild C-H functionalization (84 references).
authors.affiliation: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: Joanna
authors.initials: J
authors.lastname: Wencel-Delord
authors.forename: Thomas
authors.initials: T
authors.lastname: Dröge
authors.forename: Fan
authors.initials: F
authors.lastname: Liu
authors.forename: Frank
authors.initials: F
authors.lastname: Glorius
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D006859:Hydrogen / Q000737:chemistry; D008670:Metals / Q000737:chemistry
chemical_list: D001688:Biological Products; D008670:Metals; D002244:Carbon; D006859:Hydrogen