title: N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy.
abstract: An easy and efficient solid-phase synthesis strategy to obtain rapidly water-soluble chromophores/fluorophores in highly pure form has been developed. This first successful use of N-Fmoc-α-sulfo-β-alanine as a SPPS building block opens the way to the future development of promising direct "on-resin" peptide labelling and water-solubilising methods.
authors.affiliation: Equipe de Chimie Bio-Organique, COBRA-CNRS UMR 6014 & FR 3038, rue Lucien Tesnière, 76131 Mont-Saint-Aignan, France. anthony.romieu@univ-rouen.fr
authors.forename: Anthony
authors.initials: A
authors.lastname: Romieu
authors.forename: Thomas
authors.initials: T
authors.lastname: Bruckdorfer
authors.forename: Guillaume
authors.initials: G
authors.lastname: Clavé
authors.forename: Virgile
authors.initials: V
authors.lastname: Grandclaude
authors.forename: Cédrik
authors.initials: C
authors.lastname: Massif
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Renard
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods; D003544:Cysteic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D015394:Molecular Structure; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; C562139:N-Fmoc-alpha-sulfo-beta-alanine; D014867:Water; D003544:Cysteic Acid