title: Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.
abstract: The strong bitter peptide, Phe-Phe-Pro-Arg, activated cultured cells expressing either of the known human bitter taste receptors, hTAS2R8 and hTAS2R39. The partial structure of Pro-Arg activated hTAS2R39, but did not activate hTAS2R8. These receptors may not indiscriminately recognize bitter peptides, but have a differential function in their recognition.
authors.affiliation: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ueno
authors.forename: Takanobu
authors.initials: T
authors.lastname: Sakurai
authors.forename: Shinji
authors.initials: S
authors.lastname: Okada
authors.forename: Keiko
authors.initials: K
authors.lastname: Abe
authors.forename: Takumi
authors.initials: T
authors.lastname: Misaka
mesh_terms: D004151:Dipeptides / Q000494:pharmacology; D015870:Gene Expression; D057809:HEK293 Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D009842:Oligopeptides / Q000494:pharmacology; D010957:Plasmids; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013649:Taste / Q000187:drug effects / Q000502:physiology*; D014162:Transfection
chemical_list: D004151:Dipeptides; D009842:Oligopeptides; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D011993:Recombinant Fusion Proteins; C557300:TAS2R39 protein, human; C562003:TAS2R8 protein, human; C045406:prolylarginine; C077952:phenylalanyl-prolyl-arginine