title: Flurbiprofen encapsulation using pluronic triblock copolymers.
abstract: Pulsed-field gradient stimulated-echo nuclear magnetic resonance (NMR) and surface tension measurements have been used to study the effect of drug addition on the micellization behavior of pluronic triblock copolymers (P103, P123, and L43). The addition of 0.6 wt% flurbiprofen to Pluronic P123 and P103 solutions reduced their cmc and promoted micellization. Also, a substantial increase in the hydrodynamic radius of Pluronic P103 from 5 to 10 nm was observed, along with an increased fraction of polymer micellized, demonstrating that the polymers solubilize this nonsteroidal anti-inflammatory drug.
authors.affiliation: School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom. terence.cosgrove@bris.ac.uk
authors.forename: Shirin
authors.initials: S
authors.lastname: Alexander
authors.forename: Terence
authors.initials: T
authors.lastname: Cosgrove
authors.forename: Stuart W
authors.initials: SW
authors.lastname: Prescott
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Castle
mesh_terms: D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D005480:Flurbiprofen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure; D011060:Poloxalene / Q000737:chemistry*; D012995:Solubility; D013500:Surface Tension
chemical_list: D004655:Emulsions; D008823:Micelles; D005480:Flurbiprofen; D011060:Poloxalene