title: The comparison of cardiac biomarkers positivities in hemodialysis patients without acute coronary syndrome.
abstract: OBJECTIVE
  We aimed to compare heart-type fatty acid-binding proteins (H-FAB) and other cardiac biomarkers to determine the most reliable cardiac marker in hemodialysis (HD) patients without acute coronary syndrome (ACS).
  
  
  METHODS
  Sixty HD patients without ACS were included the study. Blood samples were taken before HD session for measurement of H-FAB, troponin I, troponin T, creatine kinase-MB (CK-MB) isoforms.
  
  
  RESULTS
  Mean age of patients was 55 ± 15 years. Males were 55%. Mean serum level of blood urea nitrogen was 75 ± 15 mg/dL, mean serum level of creatinine was 8.3 ± 2.5 mg/dL, mean serum level of hematocrit was 33 ± 5%, mean ejection fraction was 54 ± 9%, and mean left ventricular mass index (LVMI) was 136 ± 54 g/m(2). H-FAB was positive in 32%, troponin T in 20%, troponin I in 12%, and CK-MB in 5% of all patients. Three or four of all parameters were not positive together in any patient. While 5% of patients had positive troponin T with H-FAB, 3% of patients had positive troponin T with troponin I and 2% of patients had positive troponin I with H-FAB.
  
  
  CONCLUSIONS
  Our study found that CK-MB had the lowest positivity in the HD patients without ACS. H-FAB had the highest rate of positivity in all markers. If only one marker is assessed it should be CK-MB. But using two parameters in HD patients in ACS diagnosis increases the reliability of diagnosis. If we use two biomarkers it should be CK-MB and troponin I.
authors.affiliation: Department of Cardiology, Elazıg Education and Research Hospital, Elazıg, Turkey. hkorkmaz23@yahoo.com
authors.forename: Hasan
authors.initials: H
authors.lastname: Korkmaz
authors.forename: Gülşah
authors.initials: G
authors.lastname: Saşak
authors.forename: Ahmet
authors.initials: A
authors.lastname: Celik
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Kurtoğlu
authors.forename: Mehtap
authors.initials: M
authors.lastname: Gürger
authors.forename: Kazım Burak
authors.initials: KB
authors.lastname: Bursalı
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahan
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood*; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D004452:Echocardiography; D005189:False Positive Reactions; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D006435:Renal Dialysis; D013318:Stroke Volume; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins; D019210:Troponin I; D020107:Troponin T; D052279:Creatine Kinase, MB Form