title: Association of polymorphisms in angiotensin II receptor genes with aldosterone-producing adenoma.
abstract: This study examined the association of polymorphisms in angiotensin II receptor genes (AT (1) R and AT (2) R) with the risk for aldosterone-producing adenoma (APA) in a Chinese Han population. Four polymorphisms including rs5182 (573T/C) in exon 4, rs5186 (1166A/C) in 3'-untranslated region (3'-UTR) in AT (1) R gene and rs5194 (2274G/A) in 3'-UTR, rs1403543 (1675G/A) in intron 1 in AT (2) R gene were detected in 148 APA patients and 192 normal subjects (serving as control) by using a MGB-Taqman probe. The distribution of genotypes of each locus was in accordance with Hardy-Weinberg Equilibrium (HWE) in the APA and control groups (P>0.05). The allele A frequency at rs5194 was significantly higher in the APA group (0.49) than in the control group (0.35) (χ (2)=12.08, P=0.001). Subjects with homozygotic genotype AA and heterozygotic genotype GA were at an increased risk for APA as compared to those with GG genotype (OR=2.66, 95% CI=1.45-4.87; OR=1.67, 95% CI=1.02-2.74). Furthermore, rs5194 single-nucleotide polymorphism (SNP) at AT (2) R gene was significantly associated with APA in additive (OR=1.64, 95% CI=1.21-2.20, P=0.001), dominant (OR=1.94, 95% CI=1.23-3.06, P=0.003), and recessive model (OR=2.01, 95% CI=1.17-3.45, P=0.01). It was concluded that rs5194 polymorphism at AT (2) R gene was associated with the risk for APA, which may constitute a genetic marker of APA.
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100086, China.
authors.forename: Jinzhi
authors.initials: J
authors.lastname: Ouyang
authors.affiliation: Department of Urology, the First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.
authors.forename: Zhun
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Urology, the First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.
authors.forename: Jinchun
authors.initials: J
authors.lastname: Xing
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China.
authors.forename: Yongji
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Urology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
authors.forename: Guoxi
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Urology, Chinese PLA General Hospital, Beijing, 100086, China.
authors.forename: Baojun
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Urology, Chinese PLA General Hospital, Beijing, 100086, China.
authors.forename: Hongzhao
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Urology, Chinese PLA General Hospital, Beijing, 100086, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Urology, Chinese PLA General Hospital, Beijing, 100086, China. xzhang@tjh.tjmu.edu.cn.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000236:Adenoma / Q000235:genetics* / Q000378:metabolism; D000306:Adrenal Cortex Neoplasms / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D000450:Aldosterone / Q000378:metabolism*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D044139:Receptor, Angiotensin, Type 2 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D000450:Aldosterone