title: The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases.
abstract: Protein kinase C epsilon (PKC ɛ) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ɛ in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ɛ functions in vivo, and PKC ɛ has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ɛ on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ɛ could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ɛ signal pathway in the developing brain.
authors.affiliation: Neurobiology Research Center, Zhongshan Medical School, Sun Yat-sen University, Guangzhou, 510080, China. cheny33@mail.sysu.edu.cn
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Tian
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D023421:Models, Animal; D009474:Neurons / Q000502:physiology*; D051744:Protein Kinase C-epsilon / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D051744:Protein Kinase C-epsilon