title: Drimane-type sesquiterpenes from Polygonum hydropiper.
abstract: One new drimane-type sesquiterpenoid, 3 β-angeloyloxy-7-epifutronolide (1), and one new natural product, polygonumate (2), along with six known drimane-type sesquiterpenes [dendocarbin L (3), (+) winterin (4), (+) fuegin (5), changweikangic acid A (6), futronolide (7), and 7-ketoisodrimenin (8)] were isolated from the whole plant of Polygonum hydropiper Linn. Their structures were determined using spectroscopic techniques. Single-crystal X-ray diffraction study on dendocarbin L (3) and ¹³C-NMR spectroscopic data of (+) winterin (4) are described for the first time. Compound 6 was evaluated for inhibitions of α-chymotrypsin, acetylcholinesterase, and butyrylcholinesterase enzymes.
authors.affiliation: Department of Chemistry, Chittagong University of Engineering and Technology, Chittagong, Bangladesh.
authors.forename: Rajia
authors.initials: R
authors.lastname: Sultana
authors.forename: Rashadul
authors.initials: R
authors.lastname: Hossain
authors.forename: Achyut
authors.initials: A
authors.lastname: Adhikari
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.forename: Sammar
authors.initials: S
authors.lastname: Yousuf
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Muhammad Yusuff
authors.initials: MY
authors.lastname: Ali
authors.forename: Muhammad Shahed
authors.initials: MS
authors.lastname: Zaman
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects; D002091:Butyrylcholinesterase / Q000187:drug effects; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D028502:Polygonum / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: C579593:3beta-angeloyloxy-7-epifutronolide; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D002918:Chymotrypsin; C117608:alpha-chymotrypsin