title: The 981C>T polymorphism in protein tyrosine phosphatase 1B is associated with decreased risk of coronary artery disease in Chinese Han population.
abstract: OBJECTIVE
  The present study was designed to investigate the potential association between the 981C>T polymorphism in protein tyrosine phosphatase 1B (PTP-1B) and coronary artery disease (CAD).
  
  
  METHODS
  We conducted a hospital-based case-control study with 864 CAD patients and 1008 controls to explore the association between the PTP-1B 981C>T polymorphism and risk of CAD in Chinese Han population.
  
  
  RESULTS
  Subjects with the variant genotypes (CT+TT) had a 52% decreased risk of CAD relative to CC carriers (adjusted odds ratio, 0.48; 95% confidence interval, 0.39-0.60). The 981C>T polymorphism was associated with a higher body mass index and serum triglyceride levels in both CAD patients and controls. Moreover, this polymorphism was found to be associated with a lower serum glucose levels in cases, but not in controls.
  
  
  CONCLUSIONS
  Our study demonstrates that the PTP-1B 981C>T polymorphism is associated with decreased risk of CAD in Chinese Han population.
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Weiting
authors.initials: W
authors.lastname: Xu
authors.forename: Jianchang
authors.initials: J
authors.lastname: Chen
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002681:China; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000235:genetics*; D012306:Risk
chemical_list: D001786:Blood Glucose; D008055:Lipids; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1