title: Targeted and armed oncolytic adenovirus via chemoselective modification.
abstract: Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporation of non-canonical monosaccharides (O-GlcNAz) and amino acids (homopropargylglycine), which served as sites for chemoselective modification.
authors.affiliation: Department of Chemistry and Institute of Chemical Biology and Drug Discovery, State University of New York at Stony Brook, NY 11790, USA.
authors.forename: Partha S
authors.initials: PS
authors.lastname: Banerjee
authors.forename: Edison S
authors.initials: ES
authors.lastname: Zuniga
authors.forename: Iwao
authors.initials: I
authors.lastname: Ojima
authors.forename: Isaac S
authors.initials: IS
authors.lastname: Carrico
mesh_terms: D000256:Adenoviridae / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D015153:Blotting, Western; D045744:Cell Line, Tumor; D051379:Mice; D050130:Oncolytic Virotherapy