title: [Cytological and cytogenetic studies of cells of Mongolian gerbils' retinal epithelium and marrow following 12-day space flight].
abstract: The paper report the results of studying mitotic activity and cytogenetic disorders in marrow and retinal epithelium cells of Mongolian gerbils in 21 - 23 hrs. of landing space apparatus Foton-M3, and the animals of synchronous and vivarium controls. Cells of the space flown gerbils displayed a statistically significant (p < 0.05) gain in the ratio of mitosis prophases and metaphases to the sum of ana- and telophases (1.7 +/- 0.3 and 2 +/- 0.1, respectively) as compared to these parameters in the synchronous and vivarium controls, where the ratio made up 0.6 +/- 0.1 and 0.7 +/- 0.1, respectively. Frequency of aberrant mytoses in the form of bridges was increased equally in both types of cells. Patterns of chromosome damages occurred in flight infer that the major portion of changes was not due to chromosome breakage but adhesion and ensuing wrong disjunction. These results seem to have been caused by acute g-stress to organism during re-entry and return from micro-g to the normal gravity.
authors.forename: S V
authors.initials: SV
authors.lastname: Vorozhtsova
authors.forename: A N
authors.initials: AN
authors.lastname: Abrosimova
authors.forename: B S
authors.initials: BS
authors.lastname: Fedorenko
authors.forename: D V
authors.initials: DV
authors.lastname: Rakov
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D033481:Chromosomes, Mammalian; D020732:Cytogenetic Analysis / Q000379:methods*; D005500:Follow-Up Studies; D005820:Genetic Testing / Q000379:methods*; D005849:Gerbillinae; D006112:Gravitation; D008297:Male; D055213:Retinal Pigment Epithelium / Q000166:cytology*; D013026:Space Flight; D013997:Time Factors