title: Do commonly used ventilator settings for mechanically ventilated adults have the potential to embed secretions or promote clearance?
abstract: BACKGROUND
  Intubation and mechanical ventilation can impair mucociliary clearance and cause secretion retention, airway occlusion, atelectasis, and pneumonia. Animal and laboratory work has demonstrated that mechanical ventilator settings can generate a flow bias (inspiratory or expiratory)  that may result in mucus movement either away from the ventilator (deeper into the lungs) or toward the ventilator (toward the mouth), respectively. An absolute difference of 17 L/min, and a relative difference of ≥ 10%, between the expiratory and inspiratory flow have been reported as  thresholds for mucus movement.
  
  
  METHODS
  We measured baseline peak inspiratory and expiratory flows during quiet mechanical ventilation in a convenience sample of 20 intubated and ventilated adult patients.
  
  
  RESULTS
  Nineteen patients had an inspiratory flow bias of ≥ 10%. Eight patients  had an absolute mean inspiratory flow bias of ≥ 17 L/min.
  
  
  CONCLUSIONS
  Commonly used mechanical ventilator settings generate an inspiratory flow bias that may promote secretion retention.
authors.affiliation: Physiotherapy Department, Guy's and St Thomas' National Health Service Foundation Trust, London, UK. georgentou@yahoo.com
authors.forename: George
authors.initials: G
authors.lastname: Ntoumenopoulos
authors.forename: Harriet
authors.initials: H
authors.lastname: Shannon
authors.forename: Eleanor
authors.initials: E
authors.lastname: Main
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000402:Airway Obstruction / Q000517:prevention & control; D005260:Female; D006801:Humans; D007320:Inspiratory Capacity; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000502:physiology*; D009093:Mucus / Q000378:metabolism; D010366:Peak Expiratory Flow Rate; D012123:Pulmonary Ventilation; D012121:Respiration, Artificial / Q000295:instrumentation* / Q000592:standards; D055815:Young Adult