title: Three-dimensional bioactive glass implants fabricated by rapid prototyping based on CO(2) laser cladding.
abstract: Three-dimensional bioactive glass implants were produced by rapid prototyping based on laser cladding without using moulds. CO(2) laser radiation was employed to melt 45S5 and S520 bioactive glass particles and to deposit the material layer by layer following a desired geometry. Controlled thermal input and cooling rate by fine tuning of the processing parameters allowed the production of crack-free fully dense implants. Microstructural characterization revealed chemical composition stability, but crystallization during processing was extensive when 45S5 bioactive glass was used. Improved results were obtained using the S520 bioactive glass, which showed limited surface crystallization due to an expanded sintering window (the difference between the glass transition temperature and crystallization onset temperature). Ion release from the S520 implants in Tris buffer was similar to that of amorphous 45S5 bioactive glass prepared by casting in graphite moulds. Laser processed S520 scaffolds were not cytotoxic in vitro when osteoblast-like MC3T3-E1 cells were cultured with the dissolution products of the glasses; and the MC3T3-E1 cells attached and spread well when cultured on the surface of the materials.
authors.affiliation: Applied Physics Department, Universidade de Vigo, Vigo, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Comesaña
authors.forename: F
authors.initials: F
authors.lastname: Lusquiños
authors.forename: J
authors.initials: J
authors.lastname: Del Val
authors.forename: M
authors.initials: M
authors.lastname: López-Álvarez
authors.forename: F
authors.initials: F
authors.lastname: Quintero
authors.forename: A
authors.initials: A
authors.lastname: Riveiro
authors.forename: M
authors.initials: M
authors.lastname: Boutinguiza
authors.forename: A
authors.initials: A
authors.lastname: de Carlos
authors.forename: J R
authors.initials: JR
authors.lastname: Jones
authors.forename: R G
authors.initials: RG
authors.lastname: Hill
authors.forename: J
authors.initials: J
authors.lastname: Pou
mesh_terms: D000818:Animals; D002021:Buffers; D002245:Carbon Dioxide / Q000737:chemistry*; D002478:Cells, Cultured; D002516:Ceramics; D005898:Glass / Q000737:chemistry*; D007834:Lasers; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism
chemical_list: D002021:Buffers; C425330:bioactive glass 45S5; D002245:Carbon Dioxide