title: [Endothelium-protective effects of vinpocetine, pentoxifylline and enalapril in patients with chronic brain ischemia].
abstract: The influence of vinpocetine, pentoxifylline and enalapril on endothelium functions has been studied in a group of in 172 patients with chronic brain ischemia. The endothelium-protective effect of drugs was manifested as the inhibition of the Willebrand factor output during arteriovenous occlusion test and as the renewal of endothelium-depended vasodilation. The extent of neurologic deficit reduction correlated with decrease in the activated endothelium-depended output of the Willebrand factor.
authors.forename: O E
authors.initials: OE
authors.lastname: Vaizova
authors.forename: A I
authors.initials: AI
authors.lastname: Vengerovsky
authors.forename: V M
authors.initials: VM
authors.lastname: Alifirova
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004656:Enalapril / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010431:Pentoxifylline / Q000494:pharmacology; D016896:Treatment Outcome; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology; D014748:Vinca Alkaloids / Q000494:pharmacology; D014841:von Willebrand Factor / Q000037:antagonists & inhibitors / Q000276:immunology
chemical_list: D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; C013983:vinpocetine; D004656:Enalapril; D005340:Fibrinogen; D002784:Cholesterol; D010431:Pentoxifylline