title: Synthesis of collagenase-sensitive polyureas for ligament tissue engineering.
abstract: Recently, poly(ester urethanes) were investigated for use as ligament grafts due to their exceptional mechanical properties and highly tunable structure; however, these grafts are susceptible to hydrolytic degradation that occurs independent of tissue regeneration. To address this limitation, polyureas containing collagen-derived peptides were synthesized which enable cellular release of proteases to dictate degradation rate. It is hypothesized that this cell-responsive design will facilitate load transfer from the biodegradable scaffold to neotissue at a rate that promotes proper tissue orientation and function while maintaining construct integrity.
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120, USA.
authors.forename: Hugh
authors.initials: H
authors.lastname: Benhardt
authors.forename: Nick
authors.initials: N
authors.lastname: Sears
authors.forename: Tyler
authors.initials: T
authors.lastname: Touchet
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Cosgriff-Hernandez
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D003094:Collagen / Q000378:metabolism*; D017364:Collagenases / Q000378:metabolism*; D003432:Cross-Linking Reagents / Q000737:chemistry; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D008022:Ligaments / Q000187:drug effects / Q000293:injuries / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D059748:Proteolysis; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D011108:Polymers; C045786:polyurea; D011092:Polyethylene Glycols; D003094:Collagen; D017364:Collagenases