title: Concise total synthesis of (-)-8-epigrosheimin.
abstract: A highly efficient route was developed to synthesize (-)-8-epigrosheimin in four steps from aldehyde 2 based on a substrate-controlled method. The key steps of the synthesis included (1) a stereo- and regioselective allylation addition, (2) an intramolecular translactonization, and (3) an aldehyde-ene cyclization.
authors.affiliation: State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Haishen
authors.initials: H
authors.lastname: Yang
authors.forename: Yuzhe
authors.initials: Y
authors.lastname: Gao
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Qiao
authors.forename: Longguan
authors.initials: L
authors.lastname: Xie
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Xu
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D003500:Cyclization; D000081005:Cyclohexane Monoterpenes; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry*; D045789:Sesquiterpenes, Guaiane / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C561723:8-epigrosheimin; D000447:Aldehydes; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D045789:Sesquiterpenes, Guaiane; C006923:carvone