title: Physical activity among adult survivors of childhood lower-extremity sarcoma.
abstract: BACKGROUND
  Adult survivors of childhood lower-extremity sarcoma are largely physically inactive, a behavior which potentially compounds their health burden. Altering this behavior requires understanding those factors that contribute to their physical inactivity. Therefore, this investigation sought to identify factors associated with inactivity in this subpopulation of cancer survivors.
  
  
  METHODS
  Demographic, personal, treatment, and physical activity information from adult survivors of childhood lower-extremity sarcomas was obtained from the Childhood Cancer Survivor Study (CCSS) cohort. Generalized linear models were used to identify variables that best identified those individuals who were physically inactive.
  
  
  RESULTS
  Only 41% of survivors met Center for Disease Control (CDC) activity guidelines. Survivors were 1.20 (95% confidence intervals (CI) 1.11-1.30) more likely compared to CCSS sibling cohort and 1.12 (95% CI 1.10-1.15) times more likely than the general population to fail to meet CDC guidelines. Significant predictors of physical inactivity included female sex, hemipelvectomy surgery, and platinum and vinca alkaloid chemotherapy.
  
  
  CONCLUSIONS
  The primary findings of this study are that survivors of childhood onset lower-extremity sarcoma are (1) highly likely to be physically inactive and (2) less likely than their siblings or the general population to regularly exercise. This study has identified treatment-related risk factors associated with inactivity that will help health and wellness practitioners develop successful exercise interventions to help these survivors achieve recommended levels of physical activity for health.
  
  
  CONCLUSIONS
  These results suggest that physical activity interventions for adult survivors of childhood lower-extremity sarcomas should be sex specific and responsive to unique physical late effects experienced by these survivors.
authors.affiliation: Outpatient Rehabilitation, Harrison Medical Center, 2625 Wheaton Way, Bremerton, WA 98310, USA. oncologyrehab@hotmail.com
authors.forename: Meredith A
authors.initials: MA
authors.lastname: Wampler
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Galantino
authors.forename: Sujuan
authors.initials: S
authors.lastname: Huang
authors.forename: Laura S
authors.initials: LS
authors.lastname: Gilchrist
authors.forename: Victoria G
authors.initials: VG
authors.lastname: Marchese
authors.forename: G Stephen
authors.initials: GS
authors.lastname: Morris
authors.forename: David A
authors.initials: DA
authors.lastname: Scalzitti
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Oeffinger
authors.forename: Marilyn
authors.initials: M
authors.lastname: Stovall
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Leisenring
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Armstrong
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Robison
authors.forename: Kirsten K
authors.initials: KK
authors.lastname: Ness
mesh_terms: D000328:Adult; D000671:Amputation, Surgical / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000503:physiopathology* / Q000532:radiotherapy / Q000601:surgery; D015331:Cohort Studies; D003863:Depression / Q000453:epidemiology; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D007866:Leg / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000453:epidemiology; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000627:therapeutic use; D010384:Pelvic Bones / Q000601:surgery; D012509:Sarcoma / Q000503:physiopathology*; D057185:Sedentary Behavior; D012907:Smoking / Q000453:epidemiology; D012959:Socioeconomic Factors; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D011795:Surveys and Questionnaires; D017741:Survivors / Q000706:statistics & numerical data*; D014748:Vinca Alkaloids / Q000009:adverse effects / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D014748:Vinca Alkaloids