title: Pathophysiology of anaphylaxis.
abstract: OBJECTIVE
  This review aims to provide an overview of the evolving understanding of the pathophysiology of anaphylaxis.
  
  
  RESULTS
  Immunopathologic mechanisms of anaphylaxis have traditionally focused on the IgE-dependent and IgE-independent release of mediators from mast cells and basophils. There are accumulating data supporting the significance of alternative pathways of anaphylaxis. Increasing attention has also focused on the internal compensatory mechanisms activated in response to anaphylaxis.
  
  
  CONCLUSIONS
  Recent advances will enhance understanding of the pathophysiology of anaphylaxis and might have future implications for diagnosis and management.
authors.affiliation: Division of Clinical Immunology and Allergy, Department of Medicine, The University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
authors.forename: Bilal Q
authors.initials: BQ
authors.lastname: Khan
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Kemp
mesh_terms: D000707:Anaphylaxis / Q000276:immunology / Q000503:physiopathology*; D000818:Animals; D001491:Basophils / Q000378:metabolism; D002319:Cardiovascular System / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D018836:Inflammation Mediators / Q000378:metabolism; D008262:Macrophage Activation; D008407:Mast Cells / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000502:physiology; D010972:Platelet Activating Factor / Q000502:physiology; D011971:Receptors, Immunologic / Q000276:immunology; D012701:Serotonin / Q000378:metabolism; D053802:Tryptases / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D016207:Cytokines; D007074:Immunoglobulin G; D018836:Inflammation Mediators; D010972:Platelet Activating Factor; D011971:Receptors, Immunologic; D009569:Nitric Oxide; D012701:Serotonin; D007073:Immunoglobulin E; D053802:Tryptases