title: Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release.
abstract: Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.
authors.affiliation: School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China.
authors.forename: Jianmei
authors.initials: J
authors.lastname: Pang
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Luan
authors.forename: Feifei
authors.initials: F
authors.lastname: Li
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Cai
authors.forename: Jimin
authors.initials: J
authors.lastname: Du
authors.forename: Zhonghao
authors.initials: Z
authors.lastname: Li
mesh_terms: D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry*; D007700:Kinetics; D019344:Lactic Acid / Q000008:administration & dosage / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011100:Polyglycolic Acid / Q000008:administration & dosage / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D033362:Powder Diffraction
chemical_list: D003692:Delayed-Action Preparations; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D007052:Ibuprofen