title: The effectiveness of clinical practice guideline for nasopharyngeal and oropharyngeal cancer to reduce acute treatment toxicity from concurrent chemoradiation.
abstract: OBJECTIVE
  To evaluate the effectiveness of clinical practice guideline (CPG) for nasopharyngeal carcinoma (NPC) and oropharyngeal carcinoma (OPC) on reducing acute toxicity during concurrent chemoradiation (CRT).
  
  
  METHODS
  The prospective study enrolled 74 patients diagnosed of NPC and OPC that underwent concurrent CRT. The feasibility of CPG was evaluated.
  
  
  RESULTS
  Each checkpoint in CPG is feasible with 76% compliance of three in four points and 24% complete allpoints. Overall grade 3 or 4 skin reaction and mucositis are 9 and 8% respectively.
  
  
  CONCLUSIONS
  CPG that consisted of preventive methods to reduce acute skin and oral mucosa toxicities in NP and OP patients is easy to follow with 24 to 100% compliance. This can be feasible with consideration about immobilization device and energy treatment machine.
authors.affiliation: Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. sinsp@mahidol.ac.th
authors.forename: Nan
authors.initials: N
authors.lastname: Suntornpong
authors.forename: Mathurot
authors.initials: M
authors.lastname: Sukkasem
authors.forename: Chiraporn
authors.initials: C
authors.lastname: Uwattanasombat
authors.forename: Nataya
authors.initials: N
authors.lastname: Samasanti
authors.forename: Kullathorn
authors.initials: K
authors.lastname: Thephamongkol
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D008875:Middle Aged; D052016:Mucositis / Q000209:etiology; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D011832:Radiation Injuries / Q000517:prevention & control; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin