title: Multicenter analysis of survival and prognostic factors in pathologic stage I non-small-cell lung cancer according to the new 2009 TNM classification.
abstract: BACKGROUND
  The new 2009 TNM classification introduced important modifications in lung cancer staging. The aim of this study is to validate our series of patients with pathologic stage I non-small-cell lung cancer according to the 7th edition of the TNM classification of malignant tumors and to the factors related with prognosis.
  
  
  METHODS
  A multicenter retrospective study was performed. Survival rates were calculated by the Kaplan-Meier method, and for multivariate analyses, Cox proportional hazards regression model was used. The following variables were analyzed: age, sex, pathologic stage, T category, histology, type of resection and tumor size.
  
  
  RESULTS
  A total of 402 patients were included. Mean follow-up was 70.18 months. Overall 5-year survival was 68%. Males and patients over 70 had lower survival. Prognosis worsened with increasing pathologic stage, T category and tumor size. We found no statistically significant differences in prognosis for histology or type of resection. Multivariate analysis showed age, sex and pathologic stage to be independent prognostic factors.
  
  
  CONCLUSIONS
  Survival results and the analysis of prognostic factors in our series are similar to those published in the new 2009 TNM classification. The most important prognostic factor is pathologic stage. Other adverse prognostic factors include male sex and age over 70.
authors.affiliation: Sección de Cirugía Torácica, Complejo Hospitalario Universitario de Albacete, España. pabl1150@separ.es
authors.forename: Pablo
authors.initials: P
authors.lastname: León-Atance
authors.forename: Nicolás
authors.initials: N
authors.lastname: Moreno-Mata
authors.forename: Federico
authors.initials: F
authors.lastname: González-Aragoneses
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Cañizares-Carretero
authors.forename: María Dolores
authors.initials: MD
authors.lastname: García-Jiménez
authors.forename: Marta
authors.initials: M
authors.lastname: Genovés-Crespo
authors.forename: Antonio Francisco
authors.initials: AF
authors.lastname: Honguero-Martínez
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Rombolá
authors.forename: Carlos María
authors.initials: CM
authors.lastname: Simón-Adiego
authors.forename: Rafael
authors.initials: R
authors.lastname: Peñalver-Pascual
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate