title: Dead Sea Minerals loaded polymeric nanoparticles.
abstract: Therapeutic properties of Dead Sea Water (DSW) in the treatment of skin diseases such as atopic dermatitis, psoriasis and photo aging UV damaged skin have been well established. DSW is in fact rich in minerals such as calcium, magnesium, sodium, potassium, zinc and strontium which are known to exploit anti-inflammatory effects and to promote skin barrier recovery. In order to develop a Dead Sea Minerals (DSM) based drug delivery system for topical therapy of skin diseases, polymeric nanoparticles based on Poly (maleic anhydride-alt-butyl vinyl ether) 5% grafted with monomethoxy poly(ethyleneglycol) 2000 MW (PEG) and 95% grafted with 2-methoxyethanol (VAM41-PEG) loaded with DSM were prepared by means of a combined miniemulsion/solvent evaporation process. The resulting nanoparticles were characterized in terms of dimension, morphology, biocompatibility, salt content and release. Cytocompatible spherical nanoparticles possessing an average diameter of about 300 nm, a time controlled drug release profile and a high formulation yield were obtained.
authors.affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Dessy
authors.forename: Stephan
authors.initials: S
authors.lastname: Kubowicz
authors.forename: Michele
authors.initials: M
authors.lastname: Alderighi
authors.forename: Cristina
authors.initials: C
authors.lastname: Bartoli
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Piras
authors.forename: Ruth
authors.initials: R
authors.lastname: Schmid
authors.forename: Federica
authors.initials: F
authors.lastname: Chiellini
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004655:Emulsions / Q000737:chemistry; D004987:Ethers / Q000737:chemistry; D005026:Ethylene Glycols / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008299:Maleic Anhydrides / Q000737:chemistry; D051379:Mice; D008903:Minerals / Q000494:pharmacology*; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D009792:Oceans and Seas; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared; D013057:Spectrum Analysis
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004655:Emulsions; D004987:Ethers; D005026:Ethylene Glycols; D008299:Maleic Anhydrides; D008903:Minerals; D011108:Polymers; C016683:polymaleic anhydride; D011092:Polyethylene Glycols; C005219:methyl cellosolve