title: Deoxyuridines from the marine sponge associated actinomycete Streptomyces microflavus.
abstract: One new nucleoside derivative, named 3-acetyl-5-methyl-2'-deoxyuridine (1), along with two known compounds 3,5-dimethyl-2'-deoxyuridine (2) and 3-methyl-2'-deoxyuridine (3), were isolated from the cultures of Streptomyces microflavus. This strain was an associated actinomycete isolated from the marine sponge Hymeniacidon perlevis collected from the coast of Dalian (China). Their structures were elucidated by detailed NMR and MS spectroscopic analysis as well as comparison with literature data.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.affiliation: Liaoning Norm University, Dalian 116029, China.
authors.forename: Qiao-Lian
authors.initials: QL
authors.lastname: Li
authors.affiliation: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Nai-Yun
authors.initials: NY
authors.lastname: Ji
authors.affiliation: Key Laboratory of Marine Bio-resources Sustainable Utilization in Liaoning Province's University, Dalian Fisheries University, Dalian 116023, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.|Flinders Centre for Marine Bioprocessing and Bioproducts, School of Medicine, Flinders University, Adelaide, SA 5042, Australia.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Xu-Peng
authors.initials: XP
authors.lastname: Cao
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification; D003857:Deoxyuridine / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000382:microbiology*; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D003857:Deoxyuridine