title: The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release.
abstract: We have reported a novel procedure to prepare 3,5-dihydroxy-4-isopropylstilbene (DHPS) nanoemulsion, using a low-energy emulsification method. Based on the phase diagram, the optimum prescription of nanoemulsion preparation was screened. With polyoxyethylenated castor oil (EL-40) as the surfactant, ethanol as the co-surfactant, and isopropyl myristate (IPM) as the oil phase, the DHPS nanoemulsion was obtained with a transparent appearance, little viscosity, and spherically uniform distribution verified by transmission electron microscopy and laser scattering analyzer. The nanoemulsion was also determined by FT-Raman spectroscopy. The DHPS nanoemulsion demonstrated good stability and stable physical and chemical properties. The nanoemulsion dramatically improved the transdermal release of DHPS (from 8.02 μg · cm(-2) to 273.15 μg · cm(-2)) and could become a favorable new dosage form for DHPS.
authors.affiliation: College of Chemistry and Enviromental Science, Hebei University, Baoding, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jungang
authors.initials: J
authors.lastname: Gao
authors.forename: Hetang
authors.initials: H
authors.lastname: Zheng
authors.forename: Ran
authors.initials: R
authors.lastname: Zhang
authors.forename: Yucui
authors.initials: Y
authors.lastname: Han
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002368:Castor Oil / Q000031:analogs & derivatives / Q000737:chemistry; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry*; D005260:Female; D051379:Mice; D046529:Microscopy, Electron, Transmission; D009226:Myristates / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry / Q000493:pharmacokinetics; D012867:Skin / Q000378:metabolism; D012995:Solubility; D013059:Spectrum Analysis, Raman; D013267:Stilbenes / Q000737:chemistry / Q000493:pharmacokinetics; D013501:Surface-Active Agents / Q000737:chemistry; D014783:Viscosity
chemical_list: D004655:Emulsions; D009226:Myristates; D012118:Resorcinols; D013267:Stilbenes; D013501:Surface-Active Agents; C008205:isopropyl myristate; C023040:polyethoxylated castor oil; D002368:Castor Oil; C571829:tapinarof