title: Early gastric cancer combined with multiple metachronous osteosclerotic bone and bone marrow metastases that responded to chemoradiotherapy.
abstract: We report a 75-year-old woman who suffered multiple metachronous osteosclerotic bone metastases 4 years after a distal gastrectomy for early gastric cancer (EGC). The primary tumor was a poorly differentiated adenocarcinoma, which had invaded the submucosal layer, and only one lymph node metastasis was noted. To the best of our knowledge, cases of EGC combined with metachronous osteosclerotic multiple bone and bone marrow metastases that respond to chemoradiotherapy are very rare. In this case, the multiple bone metastases were diagnosed 4 years after surgery. The patient's metastatic tumor was successfully treated using S-1, paclitaxel, and camptothecin, with subsequent irradiation. The patient survived for 24 months after the treatment, without having any major symptoms.
authors.affiliation: Department of Surgery, Jichi Medical University Saitama Medical Center, Amanuma-cho 1-847, Omiya-ku, Saitama, Japan. msaito@jichi.ac.jp
authors.forename: Masaaki
authors.initials: M
authors.lastname: Saito
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kiyozaki
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Chiba
authors.forename: Osamu
authors.initials: O
authors.lastname: Takata
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Chio
authors.initials: C
authors.lastname: Shuto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yamada
authors.forename: Fumio
authors.initials: F
authors.lastname: Konishi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D019046:Bone Marrow Neoplasms / Q000556:secondary / Q000628:therapy*; D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy*; D002166:Camptothecin / Q000008:administration & dosage; D059248:Chemoradiotherapy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000473:pathology / Q000628:therapy*; D005641:Tegafur / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel; D002166:Camptothecin