title: Comparative biocidal activity of peracetic acid, benzalkonium chloride and ortho-phthalaldehyde on 77 bacterial strains.
abstract: Despite numerous reports on biocide activities, it is often difficult to have a reliable and relevant overview of bacterial resistance to disinfectants because each work challenges a limited number of strains and tested methods are often different. The aim of this study was to evaluate the bactericidal activity of three different disinfectants commonly used in industrial or medical environments (peracetic acid, benzalkonium chloride and ortho-phthalaldehyde) against 77 bacterial strains from different origins using one standard test method (NF EN 1040). Results highlight the existence of high interspecific variability of resistance to disinfectants and, contrary to widespread belief, Gram-positive strains generally appeared more resistant than Gram-negative strains. Resistance was also variable among strains of the same species such as Bacillus subtilis to peracetic acid, Pseudomonas aeruginosa to benzalkonium chloride and Staphylococcus aureus to ortho-phthalaldehyde.
authors.affiliation: AgroParisTech, UMR 1319 MICALIS, Massy, France.
authors.forename: A
authors.initials: A
authors.lastname: Bridier
authors.forename: R
authors.initials: R
authors.lastname: Briandet
authors.forename: V
authors.initials: V
authors.lastname: Thomas
authors.forename: F
authors.initials: F
authors.lastname: Dubois-Brissonnet
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000382:microbiology / Q000662:veterinary; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005516:Food Microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D010463:Peracetic Acid / Q000494:pharmacology*; D009764:o-Phthalaldehyde / Q000494:pharmacology*
chemical_list: D001548:Benzalkonium Compounds; D004202:Disinfectants; D009764:o-Phthalaldehyde; D010463:Peracetic Acid