title: Effect of TachoSil patch in prevention of postoperative pancreatic fistula.
abstract: BACKGROUND
  Postoperative pancreatic fistula (POPF) is a severe complication after pancreatic resections. The aim was to assess if application of TachoSil® patch could reduce incidence of postoperative fistulas after laparoscopic distal pancreatic resections.
  
  
  METHODS
  This is a retrospective study of prospectively collected data after enucleations and distal pancreatic resections. Patients were divided in two groups: with or without application of TachoSil® patch. Demographic and surgical data were analyzed.
  
  
  RESULTS
  One hundred twenty-one patients with distal pancreatic resections without additional resections were identified among 230 patients operated by laparoscopic approach at our institution since 1998. They were divided into two groups. In group 1 (n = 48), TachoSil® patch was not applied while in group 2 (n = 73), the pancreatic stump was covered with TachoSil®. Postoperative fistulas were registered in 8% (4/48) and 12% (9/73) in groups 1 and 2, respectively. The median duration of postoperative hospital stay in group 1 was 5.5 (2-35) days compared with 5 (2-16) days in group 2. No significant difference in surgical outcomes was found.
  
  
  CONCLUSIONS
  The application of the TachoSil® patch did not affect either occurrence of POPF or duration of postoperative hospital stay. Routine use of TachoSil® patch to prevent pancreatic fistulas does not provide clinically significant benefit.
authors.affiliation: The Interventional Centre, Oslo University Hospital, Rikshospitalet, 0027, Oslo, Norway. irinapavlik25@gmail.com
authors.forename: Irina
authors.initials: I
authors.lastname: Pavlik Marangos
authors.forename: Bård I
authors.initials: BI
authors.lastname: Røsok
authors.forename: Airazat M
authors.initials: AM
authors.lastname: Kazaryan
authors.forename: Arne R
authors.initials: AR
authors.lastname: Rosseland
authors.forename: Bjørn
authors.initials: B
authors.lastname: Edwin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004338:Drug Combinations; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use*; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000009:adverse effects*; D010185:Pancreatic Fistula / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D013917:Thrombin / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004338:Drug Combinations; C518955:TachoSil; D005340:Fibrinogen; D013917:Thrombin