title: Down-regulation of GnT-V inhibits nasopharyngeal carcinoma cell CNE-2 malignancy in vitro and in vivo.
abstract: To investigate the role of N-acetylglucosaminyltransferases V (GnT-V) in the development of human nasopharyngeal carcinoma (NPC) both in vitro and in vivo, the GnT-V stably suppressed cell line CNE-2 GnT-V/2224 was constructed from CNE-2. The studies indicated that down-regulation of GnT-V inhibited the proliferation, migration and invasion abilities of the NPC cell line CNE-2. The radio sensitivity of CNE-2 was enhanced after down-regulation of GnT-V, which may be associated with the decreased expression of bcl-2.
authors.affiliation: Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wei
authors.forename: Yahui
authors.initials: Y
authors.lastname: Li
authors.forename: Enqing
authors.initials: E
authors.lastname: Zhuo
authors.forename: Weiliang
authors.initials: W
authors.lastname: Zhu
authors.forename: Hui
authors.initials: H
authors.lastname: Meng
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis; D002277:Carcinoma; D002448:Cell Adhesion / Q000235:genetics; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics* / Q000378:metabolism*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D009361:Neoplasm Invasiveness; D011836:Radiation Tolerance
chemical_list: D017351:N-Acetylglucosaminyltransferases; C052254:alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase