title: A randomized controlled trial of emergency treatment of bleeding esophageal varices in cirrhosis for hepatocellular carcinoma.
abstract: BACKGROUND
  Ninety percent of patients with hepatocellular carcinoma (HCC) have cirrhosis. Bleeding esophageal varices (BEV) is a frequent complication of cirrhosis. Detection of HCC in cirrhotic patients with BEV has not been studied.
  
  
  METHODS
  Two hundred eleven unselected patients with cirrhosis and BEV were randomized to endoscopic sclerotherapy (n = 106) or emergency portacaval shunt (n = 105). Diagnostic workup and treatment were initiated within 8 hours. Ninety-six percent had >10 years of follow-up. HCC screening involved serum α-fetoprotein (AFP) every 3 months, ultrasonography every 6 months, and selective computed tomography (CT).
  
  
  RESULTS
  HCC occurred in 15 patients, all incurable, a mean of 2.94 years after entry. They died a mean 1.33 years after discovery. Serial AFP and ultrasound examinations were unrevealing over a mean of 2.3 years. The mean model of end-stage liver disease score was 12.7 at entry and 17.4 at HCC diagnosis.
  
  
  CONCLUSIONS
  Long-term screening by AFP and ultrasound plus selective CT failed to detect HCC at a curable stage. The detection of HCC in cirrhotic patients with BEV remains a serious, unsolved problem. The use of CT for routine screening warrants consideration despite increased costs.
authors.affiliation: Department of Surgery, University of California, San Diego, Medical Center, USA. morloff@ucsd.edu
authors.forename: Marshall J
authors.initials: MJ
authors.lastname: Orloff
authors.forename: Jon I
authors.initials: JI
authors.lastname: Isenberg
authors.forename: Henry O
authors.initials: HO
authors.lastname: Wheeler
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Haynes
authors.forename: Horacio
authors.initials: H
authors.lastname: Jinich-Brook
authors.forename: Roderick
authors.initials: R
authors.lastname: Rapier
authors.forename: Florin
authors.initials: F
authors.lastname: Vaida
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hye
authors.forename: Susan L
authors.initials: SL
authors.lastname: Orloff
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000401:mortality; D055088:Early Detection of Cancer; D004638:Emergency Treatment; D004932:Esophageal and Gastric Varices / Q000209:etiology / Q000628:therapy*; D004945:Esophagoscopy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011167:Portacaval Shunt, Surgical / Q000191:economics; D011788:Quality of Life; D015911:Sclerotherapy / Q000191:economics; D015996:Survival Rate