title: Low peritoneal and systemic inflammatory response after laparoscopy-assisted gastrectomy compared to open gastrectomy.
abstract: OBJECTIVE
  Peritoneal immune response as well as systemic response was objectively evaluated in laparoscopy-assisted distal gastrectomy (LADG) compared to open distal gastrectomy (ODG).
  
  
  METHODS
  A total of 42 patients with gastric cancer were enrolled, with 23 undergoing LADG and 19 ODG. We evaluated the levels of IL-6 in peritoneal drain fluid, serum C-reactive protein (CRP), white blood cells (WBC), and the postoperative presence of systemic inflammatory response syndrome (SIRS).
  
  
  RESULTS
  The serum CRP level was significantly higher in the ODG group than in the LADG group (p=0.007) on postoperative day (POD) 1. WBC counts showed no statistically significant difference between the two groups (p=0.105). The rate of cases exhibiting SIRS was significantly higher in the ODG group than in the LADG group (p<0.001). The IL-6 level of drain fluid was significantly higher in the ODG group than the LADG group (p<0.01) on POD1. Although weak correlation between IL-6 on POD1 and blood loss (R=0.38, p=0.0154) was observed, no significant correlation between IL-6 and operation time was noted.
  
  
  CONCLUSIONS
  LADG seems to be a lesser traumatic approach for the treatment of gastric cancer.
authors.affiliation: Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan. tnatsu22@faculty.chiba-u.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Natsume
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawahira
authors.forename: Hideki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nabeya
authors.forename: Takashi
authors.initials: T
authors.lastname: Akai
authors.forename: Daisuke
authors.initials: D
authors.lastname: Horibe
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Shuto
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Akutsu
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Matsushita
authors.forename: Fumio
authors.initials: F
authors.lastname: Nomura
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000209:etiology*; D013274:Stomach Neoplasms / Q000601:surgery*; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology*
chemical_list: D015850:Interleukin-6; D002097:C-Reactive Protein