title: Genetically engineered mouse models of diffuse gliomas.
abstract: Over the last decade, genetically engineered mouse models have been extensively used to dissect the genetic requirements for neoplastic initiation and progression of diffuse gliomas. While these models faithfully recapitulate the histopathological features of human gliomas, comparative genomic analyses are increasingly being utilized to comprehensively assess their fidelity to recently identified molecular subtypes of these tumors. Future progress with these models will rely on incorporating insights not only from oncogenomics studies of cancer, but also from the developmental neuroscience and stem cell biology fields to design accurate and experimentally tractable models for use in translational cancer research, particularly for experimental therapeutics studies of molecularly defined subtypes of gliomas.
authors.affiliation: Program in Molecular Biology and Biotechnology, University of North Carolina School of Medicine, USA.
authors.forename: Ralf S
authors.initials: RS
authors.lastname: Schmid
authors.forename: Mark
authors.initials: M
authors.lastname: Vitucci
authors.forename: C Ryan
authors.initials: CR
authors.lastname: Miller
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D055028:Comparative Genomic Hybridization; D004195:Disease Models, Animal; D018450:Disease Progression; D005818:Genetic Engineering; D005910:Glioma / Q000235:genetics*; D006801:Humans; D051379:Mice; D008818:Mice, Neurologic Mutants