title: Mechanisms of cancer-induced bone pain.
abstract: Cancer-induced bone pain (CIBP) is common and challenging to treat. Common therapies, such as opioids, radiotherapy and bisphosphonates, are often only partially effective. CIBP is a different entity to inflammatory or neuropathic pain and needs to be considered as such. This overview examines the mechanisms of CIBP; the imbalance of bone turnover, peripheral and central nervous involvement and key neurochemical mediators. The current understanding of the underlying pathophysiology of CIBP is discussed.
authors.affiliation: University of Edinburgh, Edinburgh, UK. tommiddlemiss@hotmail.com
authors.forename: T
authors.initials: T
authors.lastname: Middlemiss
authors.forename: B J A
authors.initials: BJ
authors.lastname: Laird
authors.forename: M T
authors.initials: MT
authors.lastname: Fallon
mesh_terms: D001842:Bone and Bones / Q000503:physiopathology*; D006801:Humans; D009369:Neoplasms / Q000150:complications* / Q000503:physiopathology*; D010146:Pain / Q000503:physiopathology*