title: Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors.
abstract: Staphylococcus lugdunensis is an opportunistic pathogen related to Staphylococcus aureus and Staphylococcus epidermidis. The genome sequence of S. lugdunensis strain N920143 has been compared with other staphylococci, and genes were identified that could promote survival of S. lugdunensis on human skin and pathogenesis of infections. Staphylococcus lugdunensis lacks virulence factors that characterize S. aureus and harbours a smaller number of genes encoding surface proteins. It is the only staphylococcal species other than S. aureus that possesses a locus encoding iron-regulated surface determinant (Isd) proteins involved in iron acquisition from haemoglobin.
authors.affiliation: Microbiology Department, Trinity College, Dublin, Ireland.
authors.forename: Simon
authors.initials: S
authors.lastname: Heilbronner
authors.forename: Matthew T G
authors.initials: MT
authors.lastname: Holden
authors.forename: Andries
authors.initials: A
authors.lastname: van Tonder
authors.forename: Joan A
authors.initials: JA
authors.lastname: Geoghegan
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Foster
authors.forename: Julian
authors.initials: J
authors.lastname: Parkhill
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Bentley
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D016680:Genome, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D013203:Staphylococcal Infections / Q000382:microbiology*; D057787:Staphylococcus lugdunensis / Q000235:genetics* / Q000378:metabolism; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors