title: Acute-onset bilateral myopia and ciliochoroidal effusion induced by hydrochlorothiazide.
abstract: The authors experienced two cases of hydrochlorothiazide (HCTZ)-induced acute-onset bilateral myopia and shallowing of the anterior chambers. Two middle-aged women taking HCTZ, a sulfa derivative, visited our clinic complaining of acute bilateral visual deterioration. Both had good visual acuity without corrective lenses before taking HCTZ. A complete ophthalmologic examination revealed bilateral myopic shift, intraocular pressure elevation, shallowing of the anterior chambers, choroidal effusions, radiating retinal folds, and conjunctival chemosis. Approximately one week after HCTZ discontinuance, all ocular changes disappeared completely. Physicians should be aware of the adverse ocular effects of HCTZ and should manage patients accordingly.
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Young-Rae
authors.initials: YR
authors.lastname: Roh
authors.forename: Se Joon
authors.initials: SJ
authors.lastname: Woo
authors.forename: Kyu Hyung
authors.initials: KH
authors.lastname: Park
mesh_terms: D000208:Acute Disease; D000328:Adult; D000867:Anterior Chamber / Q000187:drug effects; D002829:Choroid / Q000187:drug effects / Q000378:metabolism*; D002923:Cilia / Q000187:drug effects / Q000378:metabolism*; D004232:Diuretics / Q000009:adverse effects*; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D009216:Myopia / Q000139:chemically induced*
chemical_list: D004232:Diuretics; D006852:Hydrochlorothiazide