title: Subjective assessment of right ventricle enlargement from computed tomography pulmonary angiography images.
abstract: To retrospectively evaluate prognostic accuracy of subjective assessment of right ventricle (RV) enlargement on CT pulmonary angiography (CTPA) images in comparison with objective measures of RV enlargement in patients with acute pulmonary embolism (PE). For 200 consecutive patients with acute PE, two readers blinded to patient outcomes subjectively determined whether the maximum RV diameter was greater than that of the left ventricle (LV) using axial CTPA images. For the objective measurements, RV/LV diameter ratios were calculated using axial images and 4-chamber reformatted images. For all assessments, sensitivities and specificities for predicting PE-related death within 30-days and a composite outcome including PE-related death or the need for intensive therapies were compared. The agreement between two readers was 91.5% (kappa = 0.83) and all other assessments had pair-wise agreement over 75% (kappa = 0.53-0.72). There was no significant difference in sensitivity between the subjective and objective methods for predicting both outcomes. The specificity for subjective RV enlargement (55.4-67.7%) was significantly higher than objective measures (45.8-53.1%), except for the 4-chamber views where, for one reader, the specificity of the subjective evaluation was higher but did not reach statistical significance. Complex measurements of RV/LV diameter ratios may not be needed to maximize the prognostic value from CTPA. The radiologist who interprets the CTPA images should report RV enlargement when the RV diameter subjectively appears larger than the LV.
authors.affiliation: Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women's Hospital & Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Kanako K
authors.initials: KK
authors.lastname: Kumamaru
authors.forename: Andetta R
authors.initials: AR
authors.lastname: Hunsaker
authors.forename: Arash
authors.initials: A
authors.lastname: Bedayat
authors.forename: Shigeyoshi
authors.initials: S
authors.lastname: Soga
authors.forename: Jason
authors.initials: J
authors.lastname: Signorelli
authors.forename: Kimberly
authors.initials: K
authors.lastname: Adams
authors.forename: Nicole
authors.initials: N
authors.lastname: Wake
authors.forename: Michael T
authors.initials: MT
authors.lastname: Lu
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Rybicki
mesh_terms: D001900:Boston; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000000981:diagnostic imaging* / Q000209:etiology / Q000401:mortality; D015588:Observer Variation; D011237:Predictive Value of Tests; D011379:Prognosis; D011651:Pulmonary Artery / Q000000981:diagnostic imaging*; D011655:Pulmonary Embolism / Q000150:complications / Q000000981:diagnostic imaging* / Q000401:mortality; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013997:Time Factors; D014057:Tomography, X-Ray Computed