title: Oral mucosal graft to correct lid margin pathologic features in cicatricial ocular surface diseases.
abstract: OBJECTIVE
  To evaluate the efficacy of oral mucosal graft to correct not only lid margin keratinization and trichiasis or distichiasis, but also incomplete closure in severe cicatricial ocular surface diseases.
  
  
  METHODS
  Retrospective, noncomparative, interventional case series.
  
  
  METHODS
  Twenty-two eyes (39 eyelids) of 19 patients received an oral mucosal graft during lid margin reconstruction from September 2007 through February 2010. Relief of symptoms, conjunctival inflammation, corneal epithelial abnormalities, and visual acuity were compared before and after surgeries as outcome measures.
  
  
  RESULTS
  Among 22 eyes, 10 eyes (45.5%) had lid margin keratinization, trichiasis or distichiasis, or both, resulting in blink-related microtrauma. The oral mucosal graft resulted in successful correction in 6 eyes; in the remaining eyes, trichiasis in 3 eyes and distichiasis in 1 eye were away from the corneal surface. Incomplete closure present in 12 (54.5%) eyes was completely corrected in 9 eyes and was much improved in the remaining 3 eyes. During a mean follow-up of 16.2 months, reports of foreign body sensation, photophobia, pain, burning, tearing, and discharge were relieved significantly in 17 (77.3%) of 22 eyes. The visual acuity was improved in 13 eyes (59.1%) and was maintained in 8 eyes. Conjunctival inflammation was reduced markedly in 19 eyes (86.4%). Corneal epithelial defect and superficial punctate keratopathy were healed rapidly or improved in 14 eyes, and regression of superficial vascularization was noted in 1 eye.
  
  
  CONCLUSIONS
  Oral mucosal graft can reduce not only blink-related microtrauma caused by lid margin keratinization and trichiasis or distichiasis, but also exposure caused by cicatricially induced incomplete closure, thus preventing further deterioration of the ocular surface.
authors.affiliation: Ocular Surface Center and Ocular Surface Research & Education Foundation, Miami, Florida 33173, USA.
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu
authors.forename: Jingbo
authors.initials: J
authors.lastname: Liu
authors.forename: Scheffer C G
authors.initials: SC
authors.lastname: Tseng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005141:Eyelid Diseases / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000637:transplantation*; D013508:Ophthalmologic Surgical Procedures; D010390:Pemphigoid, Benign Mucous Membrane / Q000473:pathology / Q000601:surgery*; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D013262:Stevens-Johnson Syndrome / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D058457:Trichiasis / Q000473:pathology / Q000601:surgery; D014792:Visual Acuity / Q000502:physiology