title: A train of electrical pulses applied to the primary auditory cortex evokes a conditioned response in guinea pigs.
abstract: As a step to develop auditory prosthesis by cortical stimulation, we tested whether a single train of pulses applied to the primary auditory cortex could elicit classically conditioned behavior in guinea pigs. Animals were trained using a tone as the conditioned stimulus and an electrical shock to the right eyelid as the unconditioned stimulus. After conditioning, a train of 11 pulses applied to the left AI induced the conditioned eye-blink response. Cortical stimulation induced no response after extinction. Our results support the feasibility of auditory prosthesis by electrical stimulation of the cortex.
authors.affiliation: Department of Electronic Engineering, Graduate School of Engineering, Osaka University, Suita 565-0871, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shikata
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Song
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D001306:Auditory Pathways / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology; D001309:Auditory Threshold / Q000502:physiology; D001767:Blinking / Q000502:physiology; D003215:Conditioning, Eyelid / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods*; D005108:Extinction, Psychological / Q000502:physiology; D005240:Feasibility Studies; D006168:Guinea Pigs; D009431:Neural Conduction / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors