title: Computational opioid prescribing: a novel application of clinical pharmacokinetics.
abstract: We implemented a pharmacokinetics-based mathematical modeling technique using algebra to assist prescribers with point-of-care opioid dosing. We call this technique computational opioid prescribing (COP). Because population pharmacokinetic parameter values are needed to estimate drug dosing regimen designs for individual patients using COP, and those values are not readily available to prescribers because they exist scattered in the vast pharmacology literature, we estimated the population pharmacokinetic parameter values for 12 commonly prescribed opioids from various sources using the bootstrap resampling technique. Our results show that opioid dosing regimen design, evaluation, and modification is feasible using COP. We conclude that COP is a new technique for the quantitative assessment of opioid dosing regimen design evaluation and adjustment, which may help prescribers to manage acute and chronic pain at the point-of-care. Potential benefits include opioid dose optimization and minimization of adverse opioid drug events, leading to potential improvement in patient treatment outcomes and safety.
authors.affiliation: Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA. oalinaresmd@gmail.com
authors.forename: Oscar A
authors.initials: OA
authors.lastname: Linares
authors.forename: Annemarie L
authors.initials: AL
authors.lastname: Linares
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D010146:Pain / Q000188:drug therapy*; D019095:Point-of-Care Systems; D010818:Practice Patterns, Physicians'
chemical_list: D000701:Analgesics, Opioid