title: Weight loss precedes cancer-specific symptoms in pancreatic cancer-associated diabetes mellitus.
abstract: OBJECTIVE
  New-onset diabetes mellitus (DM) may herald pancreatic cancer (PaC). We determined whether changes in body weight distinguished PaC-associated DM (PaCDM) from type 2 DM.
  
  
  METHODS
  Among Olmsted County residents, we identified 29 PaCDM and 43 type 2 DM subjects who had serial fasting blood glucose measurements, new-onset DM, and no cancer-specific symptoms at DM onset. We compared body weight (kg) and fasting blood glucose (mg/dL) at DM onset, 1 to 2 years before and at index date in the 2 groups.
  
  
  RESULTS
  Fasting blood glucose values were similar before and at the onset of DM. Before onset of DM, PaCDM and type 2 DM subjects had similar body weight (P = 0.80). However, at onset of DM, 59% of PaCDM subjects lost weight versus 30% of type 2 DM subjects (P = 0.02). At onset of DM, 56% of type 2 DM subjects gained weight versus 31% of PaCDM subjects (P = 0.04). By index date, PaCDM subjects lost more weight than type 2 DM subjects did (8.3 ± 8.3 vs 0.8 ± 4.8 kg, P < 0.01).
  
  
  CONCLUSIONS
  Although new-onset primary type 2 DM is typically associated with weight gain, weight loss frequently precedes onset of PaCDM. The paradoxical development of diabetes in the face of ongoing weight loss may be an important clue to understanding the pathogenesis of PaCDM.
authors.affiliation: Department of Internal Medicine, Mayo Clinic, Rochester, MN55905, USA.
authors.forename: Phil A
authors.initials: PA
authors.lastname: Hart
authors.forename: Pratima
authors.initials: P
authors.lastname: Kamada
authors.forename: Kari G
authors.initials: KG
authors.lastname: Rabe
authors.forename: Sunil
authors.initials: S
authors.lastname: Srinivasan
authors.forename: Ananda
authors.initials: A
authors.lastname: Basu
authors.forename: Gaurav
authors.initials: G
authors.lastname: Aggarwal
authors.forename: Suresh T
authors.initials: ST
authors.lastname: Chari
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D013997:Time Factors; D015431:Weight Loss
chemical_list: D007004:Hypoglycemic Agents