title: Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain.
abstract: Stereoselective synthesis of novel steroidal C-20 tertiary alcohols with thiazole and pyridine side chain using Grignard reaction of steroidal ketones and thiazole/pyridine magnesium bromide have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains.
authors.affiliation: Division of Organic Chemistry, National Chemical Laboratory, Pune 411 008, India. bapushingate@gmail.com
authors.forename: Bapurao B
authors.initials: BB
authors.lastname: Shingate
authors.forename: Braja G
authors.initials: BG
authors.lastname: Hazra
authors.forename: Deepak B
authors.initials: DB
authors.lastname: Salunke
authors.forename: Vandana S
authors.initials: VS
authors.lastname: Pore
authors.forename: Fazal
authors.initials: F
authors.lastname: Shirazi
authors.forename: Mukund V
authors.initials: MV
authors.lastname: Deshpande
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002853:Chromatography, Liquid; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000890:Anti-Infective Agents; D011725:Pyridines; D013844:Thiazoles; C023666:pyridine