title: Advances in the prevention and treatment of lung cancer.
abstract: Lung cancer remains the most common fatal malignancy in the Western world. Survival rates have only improved modestly over the past three decades and new approaches are urgently required. It is clear that a concerted effort to reduce cigarette smoking is required. However, about 10% of patients with lung cancer are never smokers, indicating genetic or other predisposition. Lung cancer screening programmes are being trialled to target high-risk populations. Genetic strategies will provide new methods for screening and predicting response to treatment. Current therapy for lung cancer has reached a plateau and novel agents have shown modest clinical efficacy. Understanding the mechanisms by which chronic inflammatory disorders such as chronic obstructive pulmonary disease contribute to lung cancer development will help to identify new biological targets and biomarkers of early disease. This review focuses on recent advances in lung cancer prevention and treatment.
authors.affiliation: Department of Respiratory, Medicine and Allergy, King's College Hospital, Denmark Hill Campus, Bessemer Road, London, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Hodkinson
authors.forename: T
authors.initials: T
authors.lastname: Sethi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D000077192:Adenocarcinoma of Lung; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D049109:Cell Proliferation; D055088:Early Detection of Cancer / Q000379:methods; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy*; D009367:Neoplasm Staging / Q000379:methods; D011014:Pneumonia / Q000503:physiopathology; D012307:Risk Factors; D012907:Smoking
chemical_list: D036341:Intercellular Signaling Peptides and Proteins