title: Effect of renal function on urinary mineral excretion and stone composition.
abstract: OBJECTIVE
  To determine the effect of renal function on urinary mineral stone excretion and composition of kidney stones in patients undergoing urologic intervention for nephrolithiasis.
  
  
  METHODS
  We performed a retrospective analysis of 158 patients with 193 kidney stones who underwent endourologic intervention for nephrolithiasis. The patients were grouped by the estimated glomerular filtration rate (eGFR). The kidney stone composition and results of the 24-hour urinalysis were reported for each group. Statistical analysis was performed using the chi-square test, Kruskal-Wallis test, and analysis of variance.
  
  
  RESULTS
  The kidney stone composition profile differed significantly between the groups, with uric acid stones associated with a lower eGFR and calcium phosphate stones associated with a greater eGFR. A lower eGFR correlated with lower urine pH, lower calcium excretion, and greater oxalate excretion. Excretion of uric acid and the body mass index did not differ between groups.
  
  
  CONCLUSIONS
  Different degrees of renal function correlated with certain types of kidney stones. The urine pH was lower in patients with impaired renal function. Renal function might be an underappreciated factor that affects kidney stone composition and urinary mineral excretion.
authors.affiliation: Department of Urology, Loyola University Medical Center, Maywood, IL, USA. akadlec@lumc.edu
authors.forename: Adam O
authors.initials: AO
authors.lastname: Kadlec
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Greco
authors.forename: Zachary C
authors.initials: ZC
authors.lastname: Fridirici
authors.forename: Daniel
authors.initials: D
authors.lastname: Gerber
authors.forename: Thomas M T
authors.initials: TM
authors.lastname: Turk
mesh_terms: D000328:Adult; D002130:Calcium Phosphates / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000502:physiology*; D007669:Kidney Calculi / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D053040:Nephrolithiasis; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014527:Uric Acid / Q000652:urine; D016482:Urinalysis / Q000379:methods; D014572:Urology / Q000379:methods*
chemical_list: D002130:Calcium Phosphates; D014527:Uric Acid; C020243:calcium phosphate