title: Preparation of peptide and other biomolecular conjugates through chemoselective ligations.
abstract: The synthesis of molecular conjugates through chemoselective ligations represents a very convenient strategy to prepare complex macromolecules with diverse functional elements. Herein, we describe chemical methods based on the preparation of chemoselectively addressable peptides allowing successive oxime ligations and/or alkyne-azide cycloaddition ("click") reactions of various biomolecules. This modular synthetic approach can be applied to a broad range of purposes.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Galibert
authors.forename: Olivier
authors.initials: O
authors.lastname: Renaudet
authors.forename: Didier
authors.initials: D
authors.lastname: Boturyn
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
mesh_terms: D000085:Acetates / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D057930:Click Chemistry; D003500:Cyclization; D005231:Fatty Acids, Unsaturated / Q000737:chemistry; D005449:Fluorenes / Q000737:chemistry; D005563:Formic Acid Esters / Q000737:chemistry; D006031:Glycosylation; D007785:Lactose / Q000737:chemistry; D010084:Oxidation-Reduction; D010091:Oximes / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D012694:Serine / Q000737:chemistry; D013379:Substrate Specificity
chemical_list: C496789:9-fluorenylmethoxycarbonyl; D000085:Acetates; D000480:Alkynes; D001386:Azides; D005231:Fatty Acids, Unsaturated; D005449:Fluorenes; D005563:Formic Acid Esters; D010091:Oximes; D010455:Peptides; C000345:t-butyloxycarbonyl group; D012694:Serine; C003879:4-pentynoic acid; D007785:Lactose