title: A large proportion of esophageal cancer cases and the incidence difference between regions are attributable to lifestyle risk factors in China.
abstract: A population-based case-control study was conducted in a high-risk area (Dafeng) and a low-risk area (Ganyu) of Jiangsu province, China. In this analysis, the population attributable fraction (PAF) was calculated to quantify the etiology of risk factors; the relative attributable risk (RAR) was applied to explore how much of the incidence difference could be explained by variations in the distribution of risk factors. Results showed that unhealthy lifestyles accounted for a high fraction of esophageal cancer in China. Dissimilar distribution of several lifestyle factors, together with hereditary variations may be largely responsible for the incidence difference between areas.
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Wu
authors.forename: Pieter
authors.initials: P
authors.lastname: Van't Veer
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Zhang
authors.forename: Xu-Shan
authors.initials: XS
authors.lastname: Wang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Gu
authors.forename: Ren-Qiang
authors.initials: RQ
authors.lastname: Han
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Zhang
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Liu
authors.forename: Frans J
authors.initials: FJ
authors.lastname: Kok
authors.forename: Ellen
authors.initials: E
authors.lastname: Kampman
authors.forename: Jin-Kou
authors.initials: JK
authors.lastname: Zhao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012307:Risk Factors