title: Asymmetric synthesis of (+)-mequitazine from quinine.
abstract: The first asymmetric synthesis of the antihistaminic drug mequitazine is reported. Our approach started from quinine, a Cinchona alkaloid, whose chiral information was exploited for setting up the stereogenic center of (+)-mequitazine.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191 Gif-sur-Yvette, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Leroux
authors.forename: Laurent
authors.initials: L
authors.lastname: Larquetoux
authors.forename: Marc
authors.initials: M
authors.lastname: Nicolas
authors.forename: Eric
authors.initials: E
authors.lastname: Doris
mesh_terms: D015394:Molecular Structure; D010640:Phenothiazines / Q000138:chemical synthesis*; D011803:Quinine / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010640:Phenothiazines; D011803:Quinine; C006069:mequitazine