title: Fatal rabies despite post-exposure prophylaxis.
abstract: Only sporadic reports of failure of post-exposure prophylaxis for rabies exist in the published literature. We are reporting such a case in a 3-year-old boy. The child had Category III dog bite on his right thigh. He presented with progressive ascending paralysis, finally developing quadriplegia and respiratory paralysis. Typical hydrophobia and aerophobia were absent. He received four doses of antirabies cell culture vaccine. He did not receive antirabies immunoglobulin. The boy succumbed on the 23 rd day of the dog bite. Diagnosis of rabies was confirmed in the laboratory by demonstration of Negri bodies, direct fluorescent antibody test and reverse transcriptase-polymerase chain reaction either on impression smear of brain or a piece of brain taken during autopsy.
authors.affiliation: Department of Microbiology, Government Medical College, Panchakki Road, Aurangabad 431 001, Maharashtra, India. deshmukhdurgesh08@gmail.com
authors.forename: D G
authors.initials: DG
authors.lastname: Deshmukh
authors.forename: A S
authors.initials: AS
authors.lastname: Damle
authors.forename: J K
authors.initials: JK
authors.lastname: Bajaj
authors.forename: J B
authors.initials: JB
authors.lastname: Bhakre
authors.forename: N S
authors.initials: NS
authors.lastname: Patil
mesh_terms: D000818:Animals; D001733:Bites and Stings / Q000150:complications; D002675:Child, Preschool; D004285:Dogs; D017809:Fatal Outcome; D006624:Hippocampus / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D008853:Microscopy; D056990:Post-Exposure Prophylaxis / Q000379:methods*; D011818:Rabies / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D011819:Rabies Vaccines / Q000008:administration & dosage
chemical_list: D011819:Rabies Vaccines