title: Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals.
abstract: Infectious fungi are among a broad group of microbial pathogens that has and continues to emerge concomitantly due to the global AIDS pandemic as well as an overall increase of patients with compromised immune systems. In addition, many pathogens have been emerging and re-emerging, causing disease in both individuals who have an identifiable immune defect and those who do not. The fungal pathogen Cryptococcus gattii can infect individuals with and without an identifiable immune defect, with a broad geographic range including both endemic areas and emerging outbreak regions. Infections in patients and animals can be severe and often fatal if untreated. We review the molecular epidemiology, population structure, clinical manifestations, and ecological niche of this emerging pathogen.
authors.affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Edmond J
authors.initials: EJ
authors.lastname: Byrnes
authors.forename: Karen H
authors.initials: KH
authors.lastname: Bartlett
authors.forename: John R
authors.initials: JR
authors.lastname: Perfect
authors.forename: Joseph
authors.initials: J
authors.lastname: Heitman
mesh_terms: D000818:Animals; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology / Q000662:veterinary*; D003453:Cryptococcosis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology / Q000662:veterinary*; D056285:Cryptococcus gattii / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D004196:Disease Outbreaks; D019353:Endemic Diseases; D006801:Humans; D016867:Immunocompromised Host; D017720:Molecular Epidemiology