title: Acupuncture for hot flushes in perimenopausal and postmenopausal women: a randomised, sham-controlled trial.
abstract: OBJECTIVE
  To determine the effect of acupuncture in treating hot flushes in perimenopausal or postmenopausal women.
  
  
  METHODS
  The study was a randomised single-blind sham-controlled clinical trial. Perimenopausal or postmenopausal women with moderate or severe hot flushes were randomised to receive real or sham acupuncture. Both groups underwent a 4-week run-in period before the treatment. The real acupuncture group received 11 acupuncture treatments for 7 weeks, and the control group underwent sham acupuncture on non-acupuncture points during the same period. Both groups were followed for 8 weeks after the end of treatment period. Changes from baseline in the hot flush scores at week 7, measured by multiplying the hot flush frequency and severity, were the primary outcome. Hot flush frequency, severity and menopause-related symptoms measured with the Menopause Rating Scale Questionnaire were regarded as secondary outcomes.
  
  
  RESULTS
  54 participants were randomised into the real acupuncture group (n=27) and the sham acupuncture group (n=27). The mean change in hot flush scores was -6.4±5.2 in the real acupuncture group and -5.6±9.2 in the sham group at week 7 from values at the start of the acupuncture treatment (10.0±8.1 vs 11.7±12.6), respectively (p=0.0810). No serious adverse events were observed during the whole study period.
  
  
  CONCLUSIONS
  Compared to sham acupuncture, acupuncture failed to show significantly different effects on the hot flush scores but showed partial benefits on the hot flush severity. Further consideration is needed to develop appropriate strategies for distinguishing non-specific effects from observed overall effectiveness of acupuncture for hot flushes. Whether acupuncture has point-specific effects for hot flushes should be also considered in designing future researches.
authors.affiliation: Department of Obstetrics and Gynecology, College of Traditional Korean Medicine, Dongguk University, Seoul 100-715, South Korea. obgykdi@hanmail.net
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Kim
authors.forename: Jae Cheol
authors.initials: JC
authors.lastname: Jeong
authors.forename: Kun Hyung
authors.initials: KH
authors.lastname: Kim
authors.forename: Jin Ju
authors.initials: JJ
authors.lastname: Rho
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Choi
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Yoon
authors.forename: Sun-Mi
authors.initials: SM
authors.lastname: Choi
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Kang
authors.forename: Hong Yup
authors.initials: HY
authors.lastname: Ahn
authors.forename: Myeong Soo
authors.initials: MS
authors.lastname: Lee
mesh_terms: D015669:Acupuncture Points; D015670:Acupuncture Therapy; D005260:Female; D019584:Hot Flashes / Q000628:therapy*; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D047648:Perimenopause; D017698:Postmenopause; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires