title: Neuroendocrinal study of depression in male epileptic patients.
abstract: Endocrine changes are reported in both epilepsy and depression. The interrelationships between mood, epilepsy, and endocrine changes are not well characterized. The authors included 40 epileptic patients (20 depressed, 20 nondepressed) and 20 healthy subjects. All patients had an electroencephalogram, and were given the Hamilton Rating Scale for Depression. All subjects were tested for serum levels of cortisol, prolactin, testosterone, and thyroid hormones. Patients were medication-free. Patients had elevated prolactin and cortisol and reduced serum testosterone relative to control subjects. Depressed patients had higher cortisol levels than nondepressed. Data suggest that the effects of epilepsy and depression on cortisol, but not other hormones, may be additive.
authors.affiliation: Department of Psychiatry and Behavioral Neurosciences, Division of Endocrinology and Metabolism, Wayne State University School of Medicine, Detroit, MI, and the Department of Neuropsychiatry, Faculty of Medicine, Tanta University, Egypt. safifi@med.wayne.edu
authors.forename: Samah
authors.initials: S
authors.lastname: Afifi
authors.forename: Wael
authors.initials: W
authors.lastname: Fadel
authors.forename: Heba
authors.initials: H
authors.lastname: Morad
authors.forename: Abdo
authors.initials: A
authors.lastname: Eldod
authors.forename: Elsayed
authors.initials: E
authors.lastname: Gad
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Arfken
authors.forename: Abou
authors.initials: A
authors.lastname: Samra
authors.forename: Nash
authors.initials: N
authors.lastname: Boutros
mesh_terms: D003866:Depressive Disorder / Q000097:blood* / Q000150:complications; D004569:Electroencephalography; D004827:Epilepsy / Q000097:blood* / Q000150:complications; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood; D011569:Psychiatric Status Rating Scales; D013739:Testosterone / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D013739:Testosterone; D011388:Prolactin; D006854:Hydrocortisone