title: Descartins, the memory molecules.
abstract: Investigation of protein translation at the synapse, using functioning synaptic particles termed synaptoneurosomes, has led to identification of Fragile X protein as a key synaptic component. In its absence, some key mRNAs are translated more diffusely in the cell, and more slowly. Recent studies have implicated ERK (extracellular receptor regulated kinase) as a central factor in regulating the kinetics of translation at the synapse.
authors.affiliation: Psychology Department and Beckman Institute, University of Illinois at Urbana-Champaign, USA. i-weiler@uiuc.edu
authors.forename: Ivan Jeanne
authors.initials: IJ
authors.lastname: Weiler
mesh_terms: D000818:Animals; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000378:metabolism*; D005600:Fragile X Syndrome / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D048049:Extracellular Signal-Regulated MAP Kinases; D051860:Fragile X Messenger Ribonucleoprotein 1; D012333:RNA, Messenger