title: Endonasal endoscopic resection of esthesioneuroblastoma: the Johns Hopkins Hospital experience and review of the literature.
abstract: Esthesioneuroblastoma is an uncommon malignant tumor originating in the upper nasal cavity. The surgical treatment for this tumor has traditionally been via an open craniofacial resection. Over the past decade, there has been tremendous development in endoscopic techniques. In this report, we performed a retrospective analysis of patients with esthesioneuroblastomas treated with a purely endonasal endoscopic approach and resection at the Johns Hopkins Hospital between January 2005 and April 2010. A total of eight patients with esthesioneuroblastoma, five men and three women, were identified. Six patients were treated for primary disease, and two were treated for tumor recurrence. The modified Kadish staging was A in one patient (12.5%), B in two patients (25%), C in four patients (50%), and D in one patient (12.5%). All patients had a complete resection with negative intraoperative margins. One patient had intraoperative hypertension; there were no perioperative complications. With a mean follow-up of over 27 months, all patients are without evidence of disease. In addition, we reviewed the literature and identified several overlapping case series of patients with esthesioneuroblastoma treated via a purely endoscopic technique. Our series adds to the growing experience of expanded endonasal endoscopic surgery in the treatment of skull base tumors including esthesioneuroblastoma. Longer follow-up on a larger number of patients is required to further demonstrate the utility of endoscopic approaches in the management of this malignancy.
authors.affiliation: Department of Neurosurgery, Johns Hopkins Hospital, 600 North Wolfe Street, Phipps Building, Baltimore, MD 21287, USA. ggallia1@jhmi.edu
authors.forename: Gary L
authors.initials: GL
authors.lastname: Gallia
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Reh
authors.forename: Vafi
authors.initials: V
authors.lastname: Salmasi
authors.forename: Ari M
authors.initials: AM
authors.lastname: Blitz
authors.forename: Wayne
authors.initials: W
authors.lastname: Koch
authors.forename: Masaru
authors.initials: M
authors.lastname: Ishii
mesh_terms: D000328:Adult; D000368:Aged; D003646:Debridement; D004388:Dura Mater / Q000601:surgery; D004724:Endoscopy; D018304:Esthesioneuroblastoma, Olfactory / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000601:surgery*; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures; D009669:Nose Neoplasms / Q000601:surgery*; D011182:Postoperative Care; D011183:Postoperative Complications / Q000628:therapy; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000601:surgery; D036542:Tomography, Spiral Computed; D016896:Treatment Outcome