title: [Infantile bullous pemphigoid developing after hexavalent, meningococcal and pneumococcal vaccinations].
abstract: Bullous pemphigoid is an acquired autoimmune blistering disorder extremely uncommon in children, characterized by circulating IgG antibodies to antigens of the epidermal basement membrane zone. In general, the clinical course of this condition is good and relapses are rare. The early diagnosis and treatment are fundamental. We present a 3-month-old girl with a blistering eruption on her palms and soles, and urticarial plaques on trunk, and face, 3 weeks after vaccine at two months (hepatitis B, diphtheria, tetanus, pertussis, polio, Haemophilus influenzae B, meningococcal C, pneumococcus). The clinical course worsened with vaccinations at 4 and 6 months. The control of lesions was achieved with oral deflazacort 1 mg/kg/day, with a gradual decrease until 3 months of therapy. The patient is still in remission after 8 months of follow-up. Bullous pemphigoid has been connected with some drugs and vaccinations, 1 day to 4 weeks after receiving immunization. Although the exact mechanism of induction is unclear, this case report has a visible relationship with vaccinations.
authors.affiliation: Servicio de Dermatología, Servicios de Anatomía Patológica, Hospital Infanta Leonor, Madrid, España. mvaldira@yahoo.es
authors.forename: M
authors.initials: M
authors.lastname: Valdivielso-Ramos
authors.forename: D
authors.initials: D
authors.lastname: Velázquez
authors.forename: A
authors.initials: A
authors.lastname: Tortoledo
authors.forename: J M
authors.initials: JM
authors.lastname: Hernanz
mesh_terms: D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D005260:Female; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D022401:Meningococcal Vaccines / Q000009:adverse effects*; D010391:Pemphigoid, Bullous / Q000139:chemically induced*; D022242:Pneumococcal Vaccines / Q000009:adverse effects*; D011054:Poliovirus Vaccine, Inactivated / Q000009:adverse effects*; D017778:Vaccines, Combined / Q000009:adverse effects
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D017325:Hepatitis B Vaccines; C426944:Hexavac; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined