title: Brain protection by rapeseed oil in magnesium-deficient mice.
abstract: Diets given for 30 days with various mono-(MUFA) and poly-(PUFA) unsaturated fatty acid contents were evaluated for brain protection in magnesium-deficient mice: a commercial and three synthetic diets (n-6PUFA, n-3PUFA and MUFA-based chows enriched with 5% corn/sunflower oils 1:3, with 5% rapeseed oil and with 5% high oleic acid sunflower oil/sunflower oil 7:3, respectively). Unlike magnesium deprivation, they induced significant differences in brain and erythrocyte membrane phospholipid fatty acid compositions. n-3PUFA but not other diets protected magnesium-deficient mice against hyperactivity and moderately towards maximal electroshock- and NMDA-induced seizures. This diet also inhibited audiogenic seizures by 50%, preventing animal deaths. Because, like n-6PUFA diet, matched control MUFA diet failed to induce brain protections, alpha-linolenate (ALA) rather than reduced n-6 PUFA diet content is concluded to cause n-3PUFA neuroprotection. Present in vivo data also corroborate literature in vitro inhibition of T type calcium channels by n-3 PUFA, adding basis to ALA supplementation in human anti-epileptic/neuroprotective strategies.
authors.affiliation: NMPA, CNPS, Paris XI University, Orsay, France.
authors.forename: Nicole
authors.initials: N
authors.lastname: Pages
authors.forename: Pierre
authors.initials: P
authors.lastname: Maurois
authors.forename: Bernadette
authors.initials: B
authors.lastname: Delplanque
authors.forename: Pierre
authors.initials: P
authors.lastname: Bac
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Martin
authors.forename: Qin
authors.initials: Q
authors.lastname: Du
authors.forename: Stanley I
authors.initials: SI
authors.lastname: Rapoport
authors.forename: Joseph
authors.initials: J
authors.lastname: Vamecq
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000494:pharmacology; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006801:Humans; D008275:Magnesium Deficiency / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D023421:Models, Animal; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism; D010938:Plant Oils / Q000008:administration & dosage* / Q000494:pharmacology; D000074262:Rapeseed Oil
chemical_list: D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D018696:Neuroprotective Agents; D010743:Phospholipids; D010938:Plant Oils; D000074262:Rapeseed Oil