title: Well-differentiated teratoma in a mouse uterus.
abstract: Teratomas commonly occur in the testis and ovary, whereas in the uterus they are rare. The authors report findings for a mass detected in the uterus of a 26-week-old mouse in a colony of C57BL/6 bred in their laboratory. The mass was located in the endometrium and protruded into the lumen. Histopathologically, it consisted of abnormal diploblastic or triploblastic tissues. Bone with a growth plate and myeloid cells, as well as cartilage, was mainly observed. It also included melanocytes, exocrine gland-like cells, striated muscle, and neuron-like cells. While these tissues were accompanied by extensive necrosis, all of them were well differentiated and lacked features of malignancy, such as invasion and metastasis. This mouse had experienced parturition, but fetal tissue was not observed in the lesion. Therefore, the lesion was diagnosed as a benign teratoma, which was spontaneously developed in the uterus.
authors.affiliation: Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., Osaka, Japan. ogatak2@sc.sumitomo-chem.co.jp
authors.forename: Keiko
authors.initials: K
authors.lastname: Ogata
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kushida
authors.forename: Kaori
authors.initials: K
authors.lastname: Miyata
authors.forename: Tokuo
authors.initials: T
authors.lastname: Sukata
authors.forename: Tomoya
authors.initials: T
authors.lastname: Yamada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Uwagawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawamura
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D006651:Histocytochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D013724:Teratoma / Q000473:pathology / Q000662:veterinary*; D014594:Uterine Neoplasms / Q000473:pathology / Q000662:veterinary*; D014599:Uterus / Q000473:pathology