title: Three bianthraquinone derivatives from the mangrove endophytic fungus Alternaria sp. ZJ9-6B from the South China Sea.
abstract: Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2-C-2' linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC₅₀ values ranging from 13.1 to 29.1 μM.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.|School of Science and Engineering, Jinan University, Guangzhou 510632, China.
authors.forename: Cai-Huan
authors.initials: CH
authors.lastname: Huang
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Pan
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.affiliation: School of Science and Engineering, Jinan University, Guangzhou 510632, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Yu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Huang
authors.affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Lu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.|Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: She
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.|Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, China.
authors.forename: Yong-Cheng
authors.initials: YC
authors.lastname: Lin
mesh_terms: D000528:Alternaria / Q000737:chemistry*; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D002681:China; D002942:Circular Dichroism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012623:Seawater / Q000382:microbiology*; D014871:Water Microbiology
chemical_list: C562178:4,4',5,7',8-pentahydroxy-1,1'-dimethoxy-6',8-dimethyl-5,6,7,8-tetrahydro(2,2'-bianthracene)-9,9',10,10'-tetraone; C562180:4,4',6,7,7',8-hexahydroxy-1,1'-dimethoxy-6',7-dimethyl-5,6,7,8-tetrahydro-(2,2'-bianthracene)-9,9',10,10'-tetraone; D000880:Anthraquinones; D000970:Antineoplastic Agents