title: Unresolved inflammation: 'immune tsunami' or erosion of integrity in immune-privileged and immune-responsive tissues and acute and chronic inflammatory diseases or cancer.
abstract: BACKGROUND
  Unresolved inflammation is loss of balance between two biologically opposing arms of acute inflammation, 'Yin' (tumoricidal) and 'Yang' (tumorigenic) processes that cause disruption of protective mechanisms of immune system.
  
  
  METHODS
  
  
  
  OBJECTIVE
  Unresolved inflammation-induced exaggerated expression of apoptotic and/or wound healing mediators lead to fundamental erosion ('immune tsunami' or 'immune meltdown') of integrity in tissues that are naturally immune-responsive (immune surveillance); or immune-privileged (immune tolerance). 'Immune tsunami' refers to end results of acute or chronic immune dysfunction leading to inflammatory diseases or cancer. Acute inflammatory diseases including drug-induced cancer cachexia, would fit features of 'immune meltdown' that are otherwise described for end results of age-associated diseases. Pathogens induce rapid destruction of vascular integrity, gain access to tissues and cause excessive expression of apoptotic factors leading to multiple organ failure (MOF). Significant disruptions of immunological barriers and response shifts lead to chronic neurodegenerative and autoimmune diseases, tumor growth, malignancies and angiogenesis and loss of natural immune response balances.
  
  
  CONCLUSIONS
  Strategies to promote (stabilize) inherent properties of innate immune cells ('tumoricidal' versus 'tumorigenesis') that would influence polarization of adaptive immune (T or B) cells are key in reducing or preventing incidence of inflammatory and vascular diseases or cancer during aging process.
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, MD 20817, USA. mkgoodness@aol.com
authors.forename: Mahin
authors.initials: M
authors.lastname: Khatami
mesh_terms: D000208:Acute Disease; D056704:Adaptive Immunity; D000375:Aging / Q000276:immunology; D000818:Animals; D017209:Apoptosis; D002908:Chronic Disease; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D014945:Wound Healing
chemical_list: D018836:Inflammation Mediators