title: [Diagnostic accuracy of NT-proBNP compared with electrocardiography in detecting left ventricular hypertrophy of hypertensive origin].
abstract: Electrocardiography (ECG) is the most widely used method for diagnosing left ventricular hypertrophy (LVH) in hypertensive patients. We assessed the value of N-terminal pro-brain natriuretic peptide (NT-proBNP) determination compared with ECG for detecting LVH in 336 consecutive hypertensive patients with preserved systolic function. We found a significant correlation between NT-proBNP levels and left ventricular mass adjusted for body surface area (r=.41; P<.001). The area under the receiver operating characteristic curve was 0.75 (95% CI, 0.7-0.8). A cut-off of 74.2 pg/mL had a greater sensitivity than ECG (76.6% vs 25.5%; P<.001) and a higher negative predictive value (87.8% vs 76.6%; P<.001) in the identification of LVH. NT-proBNP determination may be a useful tool for LVH screening in hypertensive patients.
authors.affiliation: Unidad de Hipertensión Arterial, Servicio de Cardiología, Hospital Universitario de San Juan, San Juan de Alicante, Alicante, España.
authors.forename: Helder
authors.initials: H
authors.lastname: Andrade
authors.forename: Pedro
authors.initials: P
authors.lastname: Morillas
authors.forename: Jesús
authors.initials: J
authors.lastname: Castillo
authors.forename: Julián
authors.initials: J
authors.lastname: Roldán
authors.forename: Irene
authors.initials: I
authors.lastname: Mateo
authors.forename: Pilar
authors.initials: P
authors.lastname: Agudo
authors.forename: Juan
authors.initials: J
authors.lastname: Quiles
authors.forename: Vicente
authors.initials: V
authors.lastname: Bertomeu-Martínez
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000032:analysis*; D010446:Peptide Fragments / Q000032:analysis*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain