title: Acute fascioliasis--clinical and epidemiological features of four patients in Chile.
abstract: Because of its infrequent and protean presentation and the lack of clinical data, the management of acute infections with the foodborne trematode Fasciola hepatica is challenging. We report four serologically confirmed cases that illustrate our experience with this parasitic infection in Chile. All patients were adults presenting with upper abdominal pain. Other symptoms included fever, nausea/vomiting, and cutaneous manifestations. In all cases, marked eosinophilia was present. All patients lived in an urban environment, and three reported the consumption of raw watercress. Computed tomography (CT) scans showed hypodense hepatic lesions, whereas ultrasonography findings were unremarkable. One patient suffered portal vein thrombosis, which might be a rare complication of acute fascioliasis. All patients were successfully treated with triclabendazole. Our case series demonstrates that patients with acute fascioliasis typically present with a combination of upper abdominal pain, marked eosinophilia, and hypodense hepatic lesions on CT imaging. Diagnosis should be confirmed by serological investigation. A history of recent consumption of raw watercress is an important finding, but in some patients the source of infection remains obscure.
authors.affiliation: Servicio de Infectología, Hospital Militar, Santiago, Chile.
authors.forename: A
authors.initials: A
authors.lastname: Fica
authors.forename: J
authors.initials: J
authors.lastname: Dabanch
authors.forename: C
authors.initials: C
authors.lastname: Farias
authors.forename: M
authors.initials: M
authors.lastname: Castro
authors.forename: M I
authors.initials: MI
authors.lastname: Jercic
authors.forename: T
authors.initials: T
authors.lastname: Weitzel
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002677:Chile; D003952:Diagnostic Imaging; D005210:Fasciola hepatica / Q000187:drug effects / Q000472:pathogenicity*; D005211:Fascioliasis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005517:Foodborne Diseases / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D000077682:Triclabendazole; D055815:Young Adult
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole