title: High-density lipoprotein cholesterol as a predictor of clinical outcomes in patients achieving low-density lipoprotein cholesterol targets with statins after percutaneous coronary intervention.
abstract: BACKGROUND
  A low level of high-density lipoprotein cholesterol (HDL-C) is strongly associated with cardiovascular events. However, the significance of HDL-C after statin therapy on the outcome of patients who have undergone percutaneous coronary intervention (PCI) with drug eluting stents (DES) is unclear.
  
  
  OBJECTIVE
  To investigate the significance of HDL-C after statin therapy on cardiovascular events in patients with coronary artery disease after DES implantation.
  
  
  METHODS
  Patients who underwent PCI with DES from January 2004 to December 2009 were prospectively enrolled. The follow-up lipid panel of 2693 patients (median lab follow-up duration 225 days) who had continued using statins after PCI and who attained low-density lipoprotein cholesterol (LDL-C) <100 mg/dl was analysed. Major adverse cardiac events (MACE), including all-cause death, non-fatal myocardial infarction, and target vessel revascularisation according to follow-up HDL-C level (40 mg/dl for men or 50 mg/dl for women) were compared with the use of propensity scores matching.
  
  
  RESULTS
  Median follow-up duration was 832 days. 1585 (58.9%) patients had low follow-up HDL-C and 1108 had high follow-up HDL-C. The low follow-up HDL-C group had significantly higher rates of MACE. Low follow-up HDL-C was a significant independent predictor of MACE (adjusted HR 1.404, 95% CI 1.111 to 1.774, p=0.004). In further analysis with propensity scores matching, overall findings were consistent.
  
  
  CONCLUSIONS
  Raising HDL-C levels may be a subsequent goal after achieving target LDL-C levels in patients with DES implantation.
authors.affiliation: Cardiovascular Center and Cardiology Division, Seoul St Mary's Hospital, Seochogu, Seoul, 137-701, Republic of Korea.
authors.forename: Suk Min
authors.initials: SM
authors.lastname: Seo
authors.forename: Eun-Ho
authors.initials: EH
authors.lastname: Choo
authors.forename: Yoon-Seok
authors.initials: YS
authors.lastname: Koh
authors.forename: Mahn Won
authors.initials: MW
authors.lastname: Park
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Shin
authors.forename: Yoon Seok
authors.initials: YS
authors.lastname: Choi
authors.forename: Hun-Jun
authors.initials: HJ
authors.lastname: Park
authors.forename: Dong Bin
authors.initials: DB
authors.lastname: Kim
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Her
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Chul Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Pum-Joon
authors.initials: PJ
authors.lastname: Kim
authors.forename: Keon Woong
authors.initials: KW
authors.lastname: Moon
authors.forename: Kiyuk
authors.initials: K
authors.lastname: Chang
authors.forename: Hee Yeol
authors.initials: HY
authors.lastname: Kim
authors.forename: Ki Dong
authors.initials: KD
authors.lastname: Yoo
authors.forename: Doo Soo
authors.initials: DS
authors.lastname: Jeon
authors.forename: Wook Sung
authors.initials: WS
authors.lastname: Chung
authors.forename: Yong Gyu
authors.initials: YG
authors.lastname: Park
authors.forename: Ki-Bae
authors.initials: KB
authors.lastname: Seung
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D015415:Biomarkers / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D057216:Propensity Score; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors