title: Bioconcentration of ibuprofen in fathead minnow (Pimephales promelas) and channel catfish (Ictalurus punctatus).
abstract: Pharmaceutical products and their metabolites are being widely detected in aquatic environments and there is a growing interest in assessing potential risks of these substances to fish and other non-target species. Ibuprofen is one of the most commonly used analgesic drugs and no peer-reviewed laboratory studies have evaluated the tissue specific bioconcentration of ibuprofen in fish. In the current study, fathead minnow (Pimephales promelas) were exposed to 250 μg L(-1) ibuprofen for 28 d followed by a 14 d depuration phase. In a minimized bioconcentration test design, channel catfish (Ictalurus punctatus) were exposed to 250 μg L(-1) for a week and allowed to depurate for 7 d. Tissues were collected during uptake and depuration phases of each test and the corresponding proportional and kinetic bioconcentration factors (BCFs) were estimated. The results indicated that the BCF levels were very low (0.08-1.4) implying the lack of bioconcentration potential for ibuprofen in the two species. The highest accumulation of ibuprofen was observed in the catfish plasma as opposed to individual tissues. The minimized test design yielded similar bioconcentration results as those of the standard test and has potential for its use in screening approaches for pharmaceuticals and other classes of chemicals.
authors.affiliation: Department of Biological Sciences, Institute of Applied Sciences, University of North Texas, PO Box 310559, Denton, TX 76203, USA.
authors.forename: Gopinath C
authors.initials: GC
authors.lastname: Nallani
authors.forename: Peter M
authors.initials: PM
authors.lastname: Paulos
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Constantine
authors.forename: Barney J
authors.initials: BJ
authors.lastname: Venables
authors.forename: Duane B
authors.initials: DB
authors.lastname: Huggett
mesh_terms: D000818:Animals; D002397:Catfishes / Q000378:metabolism*; D003530:Cyprinidae / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods* / Q000592:standards; D005618:Fresh Water / Q000737:chemistry; D007052:Ibuprofen / Q000378:metabolism* / Q000592:standards; D008297:Male; D014874:Water Pollutants, Chemical / Q000378:metabolism* / Q000592:standards
chemical_list: D014874:Water Pollutants, Chemical; D007052:Ibuprofen