title: [Association of miR-605 and miR-149 genetic polymorphisms with related risk factors of lung cancer susceptibility].
abstract: To explore association of miR-149 and miR-605 polymorphisms with other risk factors of lung cancer susceptibility among Chinese population.
  
  
  
  Two hundred and forty-four patients with lung cancer and 243 cancer-free controls matched by age and sex were enrolled from 2002 to 2008. Peripheral venous blood samples were collected from all subjects. Single nucleotide polymorphisms (SNPs) of miR-149 and miR-605 were genotyped by PCR-RFLP. Multiple-variable logistic regression model was used to assess the association of SNPs and cancer related risk factors for lung cancer.
  
  
  
  There was not significant association of SNPs of miR-149 and miR-605 with lung cancer. A marginal significance was observed while the males with at least one G allele of miR-605 had higher risk of lung cancer (OR=1.5, 95% CI:1.0-2.3) than those with AA genotype. Increased frequency of smoking was associated with lung cancer risk. Compared with no-smoker, the subjects with <20 and >20 cigarettes/day had higher risk of lung cancer: OR (95%CI)=1.7(1.0-3.0) for <20 cigarettes, OR (95%CI)=4.2(2.3-7.6) for >20 cigarettes. There was no interaction between two genes and smoking on lung cancer.
  
  
  
  miR-149 polymorphisms may not affect lung cancer susceptibility. miR-605 gene mutant might be increase the risk of lung cancer among males. Cigarette smoking increased a risk of lung cancer, but there were not interactive effects between two gene and smoking on lung cancer.
authors.affiliation: Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310058, China.
authors.forename: Ming-wu
authors.initials: MW
authors.lastname: Zhang
authors.forename: Yun-xian
authors.initials: YX
authors.lastname: Yu
authors.forename: Ming-juan
authors.initials: MJ
authors.lastname: Jin
authors.forename: Yi-feng
authors.initials: YF
authors.lastname: Pan
authors.forename: Xia
authors.initials: X
authors.lastname: Jiang
authors.forename: Qi-long
authors.initials: QL
authors.lastname: Li
authors.forename: Xin-yuan
authors.initials: XY
authors.lastname: Ma
authors.forename: Shan-chun
authors.initials: SC
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
mesh_terms: D000368:Aged; D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: C551557:MIRN149 microRNA, human; C556602:MIRN605 microRNA, human; D035683:MicroRNAs