title: The effects of vitamin D on brain development and adult brain function.
abstract: A role for vitamin D in brain development and function has been gaining support over the last decade. Multiple lines of evidence suggest that this vitamin is actually a neuroactive steroid that acts on brain development, leading to alterations in brain neurochemistry and adult brain function. Early deficiencies have been linked with neuropsychiatric disorders, such as schizophrenia, and adult deficiencies have been associated with a host of adverse brain outcomes, including Parkinson's disease, Alzheimer's disease, depression and cognitive decline. This review summarises the current state of research on the actions of vitamin D in the brain and the consequences of deficiencies in this vitamin. Furthermore, we discuss specific implications of vitamin D status on the neurotransmitter, dopamine.
authors.affiliation: Queensland Brain Institute, University of Queensland, St. Lucia, Qld 4076, Australia.
authors.forename: James P
authors.initials: JP
authors.lastname: Kesby
authors.forename: Darryl W
authors.initials: DW
authors.lastname: Eyles
authors.forename: Thomas H J
authors.initials: TH
authors.lastname: Burne
authors.forename: John J
authors.initials: JJ
authors.lastname: McGrath
mesh_terms: D000328:Adult; D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D006801:Humans; D051379:Mice; D009422:Nervous System Diseases / Q000150:complications / Q000235:genetics / Q000378:metabolism; D018696:Neuroprotective Agents / Q000378:metabolism; D010300:Parkinson Disease / Q000150:complications / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D012559:Schizophrenia / Q000150:complications / Q000378:metabolism; D015398:Signal Transduction; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology*; D014808:Vitamin D Deficiency / Q000150:complications*
chemical_list: D018696:Neuroprotective Agents; D018167:Receptors, Calcitriol; D014807:Vitamin D; D004298:Dopamine