title: [The role of free radical oxidation and endothelial dysfunction in the onset and progression of chronic obstructive pulmonary disease].
abstract: Risk factors and basic mechanisms of chronic obstructive pulmonary disease are reviewed. An original definition of this pathology is presented taking into consideration leading pathogenetic processes in the bronchi, pulmonary parenchyma, pulmonary vessels, functional disorders and clinical syndromes.
mesh_terms: D001980:Bronchi / Q000473:pathology; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000473:pathology*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012307:Risk Factors
chemical_list: D005609:Free Radicals; D009569:Nitric Oxide