title: Frequency of panton-valentine leukocidin-producing methicillin-sensitive Staphylococcus strains in patients with complicated skin and soft tissue infection in bronx, new york.
abstract: lukF-PV was present in 36% of skin and soft tissue infection (SSTI)-derived methicillin-susceptible Staphylococcus aureus (MSSA) strains and comprised six distinct clones, which contained fewer enterotoxin genes than strains without lukF-PV. Clinical presentations and outcomes of lukF-PV(+) methicillin-resistant S. aureus (MRSA) and MSSA SSTIs were comparable. In multivariable analysis, the presence of lukF-PV remained a significant predictor for incision and drainage among MSSA strains.
authors.affiliation: Albert Einstein College of Medicine, Department of Medicine, Infectious Disease Division, 1300 Morris Park Ave., UL-1223, Bronx, NY 10461, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Kaltsas
authors.forename: Alice
authors.initials: A
authors.lastname: Guh
authors.forename: José R
authors.initials: JR
authors.lastname: Mediavilla
authors.forename: Avanish K
authors.initials: AK
authors.lastname: Varshney
authors.forename: Natalie
authors.initials: N
authors.lastname: Robiou
authors.forename: Philip
authors.initials: P
authors.lastname: Gialanellia
authors.forename: Michael
authors.initials: M
authors.lastname: Henry
authors.forename: Michael H
authors.initials: MH
authors.lastname: Levi
authors.forename: Bettina C
authors.initials: BC
authors.lastname: Fries
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005098:Exotoxins / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D007956:Leukocidins / Q000235:genetics*; D008297:Male; D008712:Methicillin / Q000494:pharmacology*; D008875:Middle Aged; D058889:Molecular Typing; D009518:New York / Q000453:epidemiology; D015995:Prevalence; D017192:Skin Diseases, Bacterial / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D018461:Soft Tissue Infections / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D013211:Staphylococcus aureus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D008712:Methicillin