title: Early and mature endothelial progenitors and VEGFR2+-cells in multiple myeloma: association with disease characteristics and variation in different cell compartments.
abstract: We analyzed (1) early endothelial progenitors (EPCs; CD34(+)/AC133(+)/VEGFR2(+)), mature EPCs (CD34(+)/VEGFR2(+)) and VEGFR2(+)-cells in bone marrow (BM)-specimens of multiple myeloma (MM)- vs. monoclonal gammopathy (MGUS)-patients and healthy controls; (2) differences of BM-, peripheral blood (PB)- and leukapheresis (LP)-samples; and (3) the association of EPCs and VEGFR2(+)-cells with MM-parameters. MM patients demonstrated highest early and mature EPCs and VEGFR2(+)-cells in the BM, particularly with advanced and active disease. Endothelial cells differed in BM-, PB- and LP-specimens, albeit seemed less associated with unfavorable prognostic MM-parameters. Our data suggest that especially VEGFR2(+)-cells and mature EPCs in MM are of value to explore further.
authors.affiliation: Department of Hematology and Oncology, Freiburg University Medical Center, Freiburg, Germany.
authors.forename: Josefina
authors.initials: J
authors.lastname: Udi
authors.forename: Dagmar
authors.initials: D
authors.lastname: Wider
authors.forename: Martina
authors.initials: M
authors.lastname: Kleber
authors.forename: Gabriele
authors.initials: G
authors.lastname: Ihorst
authors.forename: Antonia
authors.initials: A
authors.lastname: Müller
authors.forename: Ralph
authors.initials: R
authors.lastname: Wäsch
authors.forename: Monika
authors.initials: M
authors.lastname: Engelhardt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002451:Cell Compartmentation / Q000502:physiology; D018450:Disease Progression; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000378:metabolism / Q000473:pathology*; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
chemical_list: D040301:Vascular Endothelial Growth Factor Receptor-2