title: Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs.
abstract: A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[arylmethoxy]ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.
authors.affiliation: Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra Ranchi-835215, Jharkhand, India. swastikaganguly@bitmesra.ac.in
authors.forename: Swastika
authors.initials: S
authors.lastname: Ganguly
authors.forename: Vatsal Vijay
authors.initials: VV
authors.lastname: Vithlani
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Kesharwani
authors.forename: Ritu
authors.initials: R
authors.lastname: Kuhu
authors.forename: Lakshmanan
authors.initials: L
authors.lastname: Baskar
authors.forename: Papiya
authors.initials: P
authors.lastname: Mitramazumder
authors.forename: Ashok
authors.initials: A
authors.lastname: Sharon
authors.forename: Abhimanyu
authors.initials: A
authors.lastname: Dev
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D003198:Computer Simulation; D015195:Drug Design; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D015497:HIV-1 / Q000201:enzymology; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D009593:Nitroimidazoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship; D044366:Transition Temperature
chemical_list: D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D007093:Imidazoles; D009593:Nitroimidazoles; D018894:Reverse Transcriptase Inhibitors; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase