title: Potential of histone deacetylase inhibitors for bladder cancer treatment.
abstract: Bladder cancer incidence increases with age, presumably reflecting a cumulative exposure to carcinogens and ever-increasing life expectancy. While aberrant protein expression due to DNA mutations is an essential step during oncogenesis, one recent interest has been the role of epigenetic changes in regulating bladder tumor development. Because aberrant histone acetylation has been linked to malignant diseases in several cases, histone deacetylase inhibitors have great potential as new anticancer drugs owing to their ability to modulate transcription and induce differentiation and apoptosis. We herein review the current knowledge on epigenetic issues in bladder cancer, particularly regarding histone acetylation, and discuss its implications for understanding the molecular basis and treatment of this disease.
authors.affiliation: Department of Urology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan. tanji@m.ehime-u.ac.jp
authors.forename: Nozomu
authors.initials: N
authors.lastname: Tanji
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Kikugawa
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Miura
authors.forename: Toyokazu
authors.initials: T
authors.lastname: Sasaki
authors.forename: Kouji
authors.initials: K
authors.lastname: Azuma
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yokoyama
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000367:Age Factors; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D044127:Epigenesis, Genetic; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006657:Histones / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D014158:Transcription, Genetic / Q000187:drug effects; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D006657:Histones