title: [Mechanisms of asbestos-induced carcinogenesis].
abstract: Several types of fibrous stone called asbestos have been an unexpected cause of human cancer in the history. This form of mineral is considered precious in that they are heat-, friction-, and acid-resistant, are obtained easily from mines, and can be modified to any form with many industrial merits. However, it became evident that the inspiration of asbestos causes a rare cancer called malignant mesothelioma. Because of the long incubation period, the peak year for malignant mesothelioma is expected to be 2025 in Japan. Thus, it is necessary to elucidate the mechanisms of asbestos-induced mesothelial carcinogenesis. In this review, we summarize the cutting edge results of our 5-year project funded by a MEXT grant, in which local iron deposition and the characteristics of mesothelial cells are the key issues.
authors.affiliation: Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan. toyokuni@med.nagoya-u.ac.jp
authors.forename: Shinya
authors.initials: S
authors.lastname: Toyokuni
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Qian
authors.initials: Q
authors.lastname: Hu
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Nagai
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Shinya
authors.initials: S
authors.lastname: Akatsuka
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D001195:Asbestosis / Q000209:etiology*; D006801:Humans; D008654:Mesothelioma / Q000209:etiology*; D010997:Pleural Neoplasms / Q000209:etiology*