title: In vitro evaluation of the type of interaction obtained by the combination of terbinafine and itraconazole, voriconazole, or amphotericin B against dematiaceous molds.
abstract: In vitro associations using the checkerboard microdilution method indicated lower MIC ranges and MIC median values for each drug (terbinafine, itraconazole, voriconazole, and amphotericin B) in association than those obtained for each single drug. Fractional inhibitory concentration index (FIC) results showed 100% synergism in the association of terbinafine with voriconazole, 96.5% in the association of terbinafine with amphotericin B, and 75.9% in the association of terbinafine with itraconazole. Drug combinations may be useful for treatment of dematiaceous mold infections as an alternative treatment to enhance the effectiveness of each drug.
authors.affiliation: State University of Campinas-UNICAMP, School of Medical Sciences, Department of Clinical Pathology, CEP 13083-887 Campinas, São Paulo, Brazil.
authors.forename: Fernanda Simas Corrêa
authors.initials: FS
authors.lastname: Biancalana
authors.forename: Luzia
authors.initials: L
authors.lastname: Lyra
authors.forename: Angélica Zaninelli
authors.initials: AZ
authors.lastname: Schreiber
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D004347:Drug Interactions; D005658:Fungi / Q000187:drug effects; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D000077291:Terbinafine; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D000077291:Terbinafine; D065819:Voriconazole