title: Extended focus high-speed swept source OCT with self-reconstructive illumination.
abstract: We present a Bessel beam illumination FDOCT setup using a FDML Swept Source at 1300 nm with up to 440 kHz A-scan rate, and discuss its advantages for structural and functional imaging of highly scattering samples. An extended focus is achieved due to the Bessel beam that preserves its lateral extend over a large depth range. Furthermore, Bessel beams exhibit a self-reconstruction property that allows imaging even behind obstacles such as hairs on skin. Decoupling the illumination from the gaussian detection increases the global sensitivity and enables dark field imaging. Dark field imaging is useful to avoid strong reflexes from the sample surface that adversely affect the sensitivity due to the limited dynamic range of high speed 8 bit acquisition cards. In addition the possibility of contrasting capillaries with high sensitivity is shown, using inter-B-scan speckle variance analysis. We demonstrate intrinsic advantages of the extended focus configuration, in particular the reduction of the phase decorrelation effect below vessels leading to improved axial vessel definition.
authors.affiliation: Group of Biomedical Optics, Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Waehringerstrasse 13, 1090 Vienna, Austria.
authors.forename: Cedric
authors.initials: C
authors.lastname: Blatter
authors.forename: Branislav
authors.initials: B
authors.lastname: Grajciar
authors.forename: Christoph M
authors.initials: CM
authors.lastname: Eigenwillig
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wieser
authors.forename: Benjamin R
authors.initials: BR
authors.lastname: Biedermann
authors.forename: Robert
authors.initials: R
authors.lastname: Huber
authors.forename: Rainer A
authors.initials: RA
authors.lastname: Leitgeb
mesh_terms: D016477:Artifacts; D001808:Blood Vessels / Q000033:anatomy & histology*; D020405:Dermis / Q000098:blood supply; D004867:Equipment Design; D005898:Glass / Q000737:chemistry; D006801:Humans; D008029:Lighting / Q000295:instrumentation* / Q000379:methods*; D008833:Microcirculation; D008863:Microspheres; D011137:Polystyrenes / Q000737:chemistry; D012542:Scattering, Radiation; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*
chemical_list: D011137:Polystyrenes