title: Linear IgA bullous dermatosis in tunisian children: 31 cases.
abstract: BACKGROUND
  Linear IgA bullous dermatosis (LAD) of children is relatively frequent in Africa.
  
  
  OBJECTIVE
  We undertook this study to evaluate the frequency of this disease among autoimmune bullous diseases (AIBDs) in Tunisian children.
  
  
  METHODS
  We present a 32-year retrospective study (January 1976 to December 2007). Children with chronic acquired bullous diseases seen at the Charles Nicolle Hospital of Tunis and for who direct immunofluorescence (DIF) of the perilesional skin demonstrated linear IgA immunoglobulin deposits were included in the study population.
  
  
  RESULTS
  Thirty-one children with LAD were selected representing 65.9% of all AIBDs of children selected in the same period, with a mean age of 5.5 years and a sex ratio (M/F) of 2.4. Most of the children had generalized eruption (28/31), more profuse on the face, pelvic region, buttocks and limbs. Mucosal lesions happened in only four children (12.9%). The mean duration of the disease was 14 months. DIF demonstrated linear IgA deposits along the dermal-epidermal junction in all patients. IgG, IgM, and complement were also seen (20/31). Indirect immunofluorescence was negative in 67% of cases. Eight patients responded to dapsone; however, prednisone had to be added in seven children to control the disease and erythromycin in four others. A long-term remission period was achieved in 76.1% of patients.
  
  
  CONCLUSIONS
  This study confirms that LAD is the most common AIBD in children in Tunisia which frequently occurs in preschool-aged males. Independently of the used drug, a long-term remission is frequently observed.
authors.affiliation: Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia.
authors.forename: Kharfi
authors.initials: K
authors.lastname: Monia
authors.forename: Khaled
authors.initials: K
authors.lastname: Aida
authors.forename: Karaa
authors.initials: K
authors.lastname: Amel
authors.forename: Zaraa
authors.initials: Z
authors.lastname: Ines
authors.forename: Fazaa
authors.initials: F
authors.lastname: Becima
authors.forename: Kamoun Mohamed
authors.initials: KM
authors.lastname: Ridha