title: [Thrombophilia and principle of thrombosis prevention in obstetrics].
abstract: One of the major causes of maternity death are complications of venous thromboembolism (VT). Risk of their occurrence during pregnancy is 5 to 10 times higher comparing to non-pregnant women. Hereditary trombophilia and antiphospholipid syndrome increase the risk of complications of venous thromboembolism significantly. In addition to VT, trombophilia is associated with miscarriage, placental abruption and severe preeclampsia. The aggravating factor is the presence of certain limitations in administration of some medications for thrombosis prophylaxis during pregnancy. Issues of medical care in pregnant patients with thrombophilia, artificial heart valves or acute VT complications are highlighted in the article, as well as principles of thrombosis prophylaxis during cesarean section or in women with VT in anamnesis. Evidence based recommendations of the recent American College of Chest Physicians consensus conference are presented for each issue.
authors.forename: S V
authors.initials: SV
authors.lastname: Sin'kov
authors.forename: I B
authors.initials: IB
authors.lastname: Zabolotskikh
authors.forename: G A
authors.initials: GA
authors.lastname: Penzhoian
authors.forename: V P
authors.initials: VP
authors.lastname: Muzychenko
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000517:prevention & control*; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D019851:Thrombophilia / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D054556:Venous Thromboembolism / Q000097:blood / Q000517:prevention & control*; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D014812:Vitamin K