title: Recyclable heterogeneous copper oxide on alumina catalyzed coupling of phenols and alcohols with aryl halides under ligand-free conditions.
abstract: An efficient alumina-supported CuO-catalyzed O-arylation of phenols and aliphatic alcohols with various aryl as well as heteroaryl halides under ligand-free conditions are reported. This protocol provides a variety of diaryl ether and bis-diaryl ether motifs by reacting different aryl/aliphatic halides with differently substituted phenols and saturated alcohols in the presence of a catalytic amount of CuO on alumina and KOH as a base at moderate temperature under nitrogen atmosphere. The described methodology is simple, straightforward and efficient to afford the cross-coupled products in high yields under ligand-free conditions. The explored catalyst is inexpensive, air-stable and recyclable up to three cycles.
authors.affiliation: Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500607, India.
authors.forename: Kokkirala
authors.initials: K
authors.lastname: Swapna
authors.forename: Sabbavarapu Narayana
authors.initials: SN
authors.lastname: Murthy
authors.forename: Mocharla Tarani
authors.initials: MT
authors.lastname: Jyothi
authors.forename: Yadavalli Venkata Durga
authors.initials: YV
authors.lastname: Nageswar
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000537:Aluminum Oxide / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*
chemical_list: D000438:Alcohols; D006841:Hydrocarbons, Aromatic; D006846:Hydrocarbons, Halogenated; D010636:Phenols; D003300:Copper; D000537:Aluminum Oxide; C000520:cuprous oxide