title: Lack of association between polymorphism -592A/C in the promoter region of the IL10 gene and Tourette's syndrome in a family-based association study in the Chinese Han population.
abstract: We evaluated the genetic contribution of the IL10-592A/C polymorphism in 108 trios with Tourette's syndrome (TS) including all their parents in a Chinese Han population by using the transmission disequilibrium test and haplotype relative risk design; no evidence for association or linkage disequilibrium was found between IL10-592A/C polymorphism and TS. These results suggested that IL10 may not play a major role in the development of TS in the Chinese Han population.
authors.affiliation: Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.forename: Mingji
authors.initials: M
authors.lastname: Yi
authors.forename: Fengguang
authors.initials: F
authors.lastname: Qi
authors.forename: Fengyuan
authors.initials: F
authors.lastname: Che
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005190:Family; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D005879:Tourette Syndrome / Q000208:ethnology / Q000235:genetics*
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10