title: Golgi biogenesis.
abstract: The Golgi is an essential membrane-bound organelle in the secretary pathway of eukaryotic cells. In mammalian cells, the Golgi stacks are integrated into a continuous perinuclear ribbon, which poses a challenge for the daughter cells to inherit this membrane organelle during cell division. To facilitate proper partitioning, the mammalian Golgi ribbon is disassembled into vesicles in early mitosis. Following segregation into the daughter cells, a functional Golgi is reformed. Here we summarize our current understanding of the molecular mechanisms that control the mitotic Golgi disassembly and postmitotic reassembly cycle in mammalian cells.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA. yzwang@umich.edu
authors.forename: Yanzhuang
authors.initials: Y
authors.lastname: Wang
authors.forename: Joachim
authors.initials: J
authors.lastname: Seemann
mesh_terms: D000818:Animals; D006056:Golgi Apparatus / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure; D008322:Mammals; D008561:Membrane Fusion; D008938:Mitosis / Q000502:physiology