title: Protective effects of hominis placenta hydrolysates on radiation enteropathy in mice.
abstract: The aim of this study was to investigate whether the hominis placenta hydrolysates (HPhs) have a protective effect against radiation-induced enteropathies. HPh (1-10 mg kg⁻¹, i.p.) was treated to C57BL/6 mice, once daily for 5 days. Mice were irradiated (10 Gy) 1 h after the last injection. Cell damage was investigated at 24 and 72 h by haematoxylin-eosin staining, and the apoptotic index was determined at 24 h by deoxynucleotidyl transferase-mediated dUTP nick end labelling staining. The results showed that the HPh alleviated radiation-induced damage of crypts and suppressed apoptosis dose dependently. In conclusion, hominis placenta might be a beneficial agent against radiation-induced intestinal complications.
authors.affiliation: Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul 130-701, Korea.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Jang
authors.forename: Jae-Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Youngmin
authors.initials: Y
authors.lastname: Bu
authors.forename: Jin-Oh
authors.initials: JO
authors.lastname: Kang
authors.forename: Jinsung
authors.initials: J
authors.lastname: Kim
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004751:Enteritis / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006652:Histological Techniques; D020287:In Situ Nick-End Labeling; D007421:Intestine, Small / Q000166:cytology / Q000473:pathology; D051379:Mice; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D011492:Protein Hydrolysates / Q000032:analysis / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000473:pathology / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011878:Radiotherapy / Q000009:adverse effects*
chemical_list: D011492:Protein Hydrolysates; D011837:Radiation-Protective Agents