title: Intrahospital weight and aerobic training in children with cystic fibrosis:  a randomized controlled trial.
abstract: OBJECTIVE
  The purpose of our study was to assess the effects of an 8-wk intrahospital combined circuit weight and aerobic training program performed by children with cystic fibrosis (of low-moderate severity and stable clinical condition) on the following outcomes: cardiorespiratory fitness (VO2peak) and muscle strength (five-repetition maximum (5RM) bench press, 5RM leg press, and 5RM seated row) (primary outcomes) and pulmonary function (forced vital capacity, forced expiratory volume in 1 s), weight, body composition, functional mobility (Timed Up and Down Stairs and 3-m Timed Up and Go tests), and quality of life (secondary outcomes). We also determined the effects of a detraining period (4 wk) on the aforementioned outcomes.
  
  
  METHODS
  We performed a randomized controlled trial design. Eleven participants in each group (controls: 7 boys, age = 11 ± 3 yr, body mass index = 17.2 ± 0.8 kg · m(-2) (mean ± SEM); intervention: 6 boys, age = 10 ± 2 yr, body mass index = 18.4 ± 1.0 kg · m(-2)) started the study.
  
  
  RESULTS
  Adherence to training averaged 95.1% ± 7.4%. We observed a significant group × time interaction effect (P = 0.036) for VO2peak. In the intervention group, VO2peak significantly increased with training by 3.9 mL · kg(-1) · min(-1) (95% confidence interval = 1.8-6.1 mL · kg(-1) · min(-1), P = 0.002), whereas it decreased during the detraining period (-3.4 mL · kg(-1) · min(-1), 95% confidence interval = -5.7 to -1.7 mL · kg(-1) · min(-1), P = 0.001). In contrast, no significant changes were observed during the study period within the control group. Although significant improvements were also observed after training for all 5RM strength tests (P < 0.001 for the interaction effect), the training improvements were not significantly decreased after the detraining period in the intervention group (all P > 0.1 for after training vs detraining). We found no significant training benefits in any of the secondary outcomes.
  
  
  CONCLUSIONS
  A short-term combined circuit weight and aerobic training program performed in a hospital setting induces significant benefits in the cardiorespiratory fitness and muscle strength of children with cystic fibrosis.
authors.affiliation: European University of Madrid, Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Santana Sosa
authors.forename: Iris F
authors.initials: IF
authors.lastname: Groeneveld
authors.forename: Laura
authors.initials: L
authors.lastname: Gonzalez-Saiz
authors.forename: Luis M
authors.initials: LM
authors.lastname: López-Mojares
authors.forename: José R
authors.initials: JR
authors.lastname: Villa-Asensi
authors.forename: María I
authors.initials: MI
authors.lastname: Barrio Gonzalez
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Fleck
authors.forename: Margarita
authors.initials: M
authors.lastname: Pérez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000628:therapy*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D010349:Patient Compliance; D010809:Physical Fitness / Q000502:physiology; D011788:Quality of Life; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014891:Weight Lifting / Q000502:physiology*