title: Favorable outcome after life-threatening meningococcal disease complicating influenza A(H1N1) infection.
abstract: OBJECTIVE
  Neurological complications of influenza A(H1N1) have been reported in several patients since the onset of the pandemic in 2009. However, meningococcal disease complicating influenza A(H1N1) has not been reported.
  
  
  METHODS
  Two patients were admitted to an intensive care unit (ICU) for altered mental status, fever, and rapidly spreading petechial purpura. They were diagnosed with meningococcal meningitis and/or meningococcemia and influenza A(H1N1) co-infection.
  
  
  CONCLUSIONS
  Meningococcal disease presenting as meningitis and/or meningococcemia is among the potential complications of influenza A(H1N1) infection. Physicians should be aware of this co-infection, as it must be detected and treated promptly with antibiotics in addition to supportive care.
authors.affiliation: Intensive Care Unit, CH Versailles, Site André Mignot, 177 rue de Versailles, Le Chesnay, France. slegriel@ch-versailles.fr
authors.forename: S
authors.initials: S
authors.lastname: Legriel
authors.forename: S
authors.initials: S
authors.lastname: Merceron
authors.forename: P
authors.initials: P
authors.lastname: Tattevin
authors.forename: M-A
authors.initials: MA
authors.lastname: Mouvier
authors.forename: S
authors.initials: S
authors.lastname: Marque-Juillet
authors.forename: A
authors.initials: A
authors.lastname: Le Monnier
authors.forename: J-P
authors.initials: JP
authors.lastname: Bedos
authors.forename: F
authors.initials: F
authors.lastname: Bruneel
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D060085:Coinfection / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005602:France; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D008589:Meningococcal Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D009345:Neisseria meningitidis / Q000187:drug effects / Q000302:isolation & purification*; D009422:Nervous System Diseases / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents