title: First three reported cases of nosocomial fungemia caused by Candida auris.
abstract: Candida auris is a newly described species whose clinical significance is not clear. Here, we describe the first three cases of nosocomial fungemia caused by C. auris, which confirms that it is a causative agent of bloodstream infections. All three patients presented persistent fungemia for 10 to 31 days. The isolates obtained from the three patients were misidentified as Candida haemulonii and Rhodotorula glutinis by the Vitek 2 and the API 20C systems, respectively. C. auris was confirmed by sequence analysis of the internal transcribed spacer region and D1/D2 regions of the 26S ribosomal DNA of the rRNA gene. The MIC ranges of amphotericin B (AMB), fluconazole (FLU), itraconazole, and voriconazole were 0.5 to 1, 2 to 128, 0.125 to 2, and 0.06 to 1 μg/ml, respectively. All isolates were susceptible to caspofungin (MIC = 0.06 μg/ml) and micafungin (MIC = 0.03 μg/ml). One patient developed breakthrough fungemia while receiving FLU therapy, and two patients who received FLU therapy followed by AMB showed therapeutic failure and fatal outcomes. Our cases show that C. auris fungemia can be persistent, despite FLU or AMB therapy, which emphasizes the importance of accurately identifying this species.
authors.affiliation: Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: Wee Gyo
authors.initials: WG
authors.lastname: Lee
authors.forename: Jong Hee
authors.initials: JH
authors.lastname: Shin
authors.forename: Young
authors.initials: Y
authors.lastname: Uh
authors.forename: Min Gu
authors.initials: MG
authors.lastname: Kang
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Kyung Hwa
authors.initials: KH
authors.lastname: Park
authors.forename: Hee-Chang
authors.initials: HC
authors.lastname: Jang
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology; D002175:Candida / Q000145:classification* / Q000302:isolation & purification*; D058387:Candidemia / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D003428:Cross Infection / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D016533:Mycological Typing Techniques / Q000379:methods; D017422:Sequence Analysis, DNA
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer