title: Metabolites and tissue distribution of resveratrol in the pig.
abstract: METHODS
  trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism and tissue distribution of RES using the pig, a mammal physiologically close to humans.
  
  
  RESULTS
  Forty-seven tissues, organs and fluids were analyzed 6 h after intragastric RES administration (5.9 mg/kg body weight) using HPLC-MS/MS. Twelve RES and seven dihydroresveratrol (DH-RES) metabolites were detected. DH-RES was the main metabolite in cecum, colon and rectum, whereas RES-3-O-glucuronide was the most abundant one in fluids and organs. Approximately 74.5% of the total RES administered was recovered in the form of RES, DH-RES and derived metabolites (65.1% along the gastrointestinal tract, 7.7% in urine, 1.2% in bile and 0.5% in organs). We report here, for the first time, the occurrence of RES ribosyl-sulfate derivative, DH-RES diglucuronide, DH-RES sulfoglucuronide and DH-RES disulfate as well as the metabolic profile of RES and DH-RES in the aorta, lymph, lymph node, ovaries, uterus, cerebellum, pancreas, urinary bladder tissue, fat and muscle.
  
  
  CONCLUSIONS
  This study contributes to the clarification of the metabolism and tissue distribution of RES and could help to further understand the mechanisms underlying its effects.
authors.affiliation: Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Campus de Espinardo, Murcia, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Azorín-Ortuño
authors.forename: María J
authors.initials: MJ
authors.lastname: Yáñez-Gascón
authors.forename: Fernando
authors.initials: F
authors.lastname: Vallejo
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Pallarés
authors.forename: Mar
authors.initials: M
authors.lastname: Larrosa
authors.forename: Ricardo
authors.initials: R
authors.lastname: Lucas
authors.forename: Juan C
authors.initials: JC
authors.lastname: Morales
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Tomás-Barberán
authors.forename: María T
authors.initials: MT
authors.lastname: García-Conesa
authors.forename: Juan C
authors.initials: JC
authors.lastname: Espín
mesh_terms: D000818:Animals; D041981:Gastrointestinal Tract / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000378:metabolism*; D013552:Swine; D014018:Tissue Distribution
chemical_list: D013267:Stilbenes; D000077185:Resveratrol