title: The bacterial second messenger c-di-GMP: mechanisms of signalling.
abstract: Cyclic-di-GMP (c-di-GMP) regulates many important bacterial processes. Freely diffusible intracellular c-di-GMP is determined by the action of metabolizing enzymes that allow integration of numerous input signals. c-di-GMP specifically regulates multiple cellular processes by binding to diverse target molecules. This review highlights important questions in research into the mechanisms of c-di-GMP signalling and its role in bacterial physiology.
authors.affiliation: Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Erez
authors.initials: E
authors.lastname: Mills
authors.forename: Ingrid S
authors.initials: IS
authors.lastname: Pultz
authors.forename: Hemantha D
authors.initials: HD
authors.lastname: Kulasekara
authors.forename: Samuel I
authors.initials: SI
authors.lastname: Miller
mesh_terms: D000222:Adaptation, Physiological; D018407:Bacterial Physiological Phenomena; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D008954:Models, Biological; D015290:Second Messenger Systems
chemical_list: C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP