title: Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption.
abstract: Intravascular large B cell lymphoma (IVLBCL) presents various neurological symptoms, and the prognosis frequently deteriorates with a delay in diagnosis. In addition, for the diagnosis of IVLBCL, invasive biopsies are generally performed in main organs, such as the brain. We report a case of IVLBCL in which an early diagnosis was enabled by skin biopsy. The patient in this case had cauda equine syndrome and had developed multiple brain infarctions. She received six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) treatment and is currently in complete remission. At the macroscopic level, her lesions resembled senile angioma, commonly observed in normal elderly persons. Eruptions of this type are not currently recognised as IVLBCL lesions and might easily be overlooked. In cases in which IVLBCL could be suspected, an active search and biopsy of skin lesions, including an eruption of this type, are useful for early diagnosis and treatment.
authors.affiliation: Department of Dermatology, Graduate school of Comprehensive Human Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nakamagoe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawachi
authors.forename: Ai
authors.initials: A
authors.lastname: Hosaka
authors.forename: Harumi
authors.initials: H
authors.lastname: Mukai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Chiba
authors.forename: Fujio
authors.initials: F
authors.lastname: Otsuka
authors.forename: Akira
authors.initials: A
authors.lastname: Tamaoka