title: Prevention of pleural adhesions using a membrane containing polyethylene glycol in rats.
abstract: BACKGROUND
  Recurrent thoracotomies regardless of the cause are not a rare occurrence. However, each thoracotomy results in adhesion to some extent. This adhesions increase morbidity and mortality presents a significant inconvenience for surgeons and prolongs the length of operations.
  
  
  OBJECTIVE
  We investigated the efficacy of Prevadh®, an anti-adhesion agent to prevent intrapleural adesions following thoracotomy in a rat model.
  
  
  METHODS
  Twenty male adult Wistar Albino rats were divided into a sham group (Group A, n = 4), a control group (Group B, n = 8), and a study group (Group C, n = 8). Only left thoracotomy was performed in Group A. Group B underwent left thoracotomy, induction of adhesion, and 1 ml saline solution was administered to the thoracic cavity. However, in Group C underwent left thoracotomy, induction of adhesion, and Prevadh® was placed between the pleura and the lung. The rats were sacrificed on day 21, and adhesions were analyzed using both macroscopic and histopathological methods. The results were statistically analyzed. A value of P<0.05 was considered statistically significant.
  
  
  RESULTS
  Mean lengths of adhesion differed statistically significantly among all three groups, while mean intensity of adhesion differed between Group A and Group B, and between Group B and Group C (P>0.05). There was also a statistically significant difference between Group A and Group C in mesothelium proliferation score (P>0.05). No statistically significant differences were found among the groups in terms of pleural thickness, macrophage and mononuclear cell infiltration (P>0.05).
  
  
  CONCLUSIONS
  Prevadh® was shown in a rat model to effectively prevent post-thoracotomy adhesions.
authors.affiliation: Department of Thoracic Surgery, State Hospital, Bilecik, Turkey. volkan_karacam@yahoo.com
authors.forename: Volkan
authors.initials: V
authors.lastname: Karacam
authors.forename: Ahmet
authors.initials: A
authors.lastname: Onen
authors.forename: Aydin
authors.initials: A
authors.lastname: Sanli
authors.forename: Duygu
authors.initials: D
authors.lastname: Gurel
authors.forename: Aydanur
authors.initials: A
authors.lastname: Kargi
authors.forename: Sami
authors.initials: S
authors.lastname: Karapolat
authors.forename: Nezih
authors.initials: N
authors.lastname: Ozdemir
mesh_terms: D000818:Animals; D003094:Collagen; D004311:Double-Blind Method; D005990:Glycerol; D008297:Male; D008567:Membranes, Artificial; D010995:Pleural Diseases / Q000517:prevention & control*; D011092:Polyethylene Glycols; D011446:Prospective Studies; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D008567:Membranes, Artificial; D011092:Polyethylene Glycols; D003094:Collagen; D005990:Glycerol