title: Coexıstence of advanced age and female gender in dıabetıcs wıth extrapulmonary tuberculosıs: four culture-proven cases.
abstract: BACKGROUND
  The relationship between diabetes mellitus (DM) and tuberculosis (TB) has long been known, but the extent of the relationship has only recently been demonstrated. It has been suggested that the presence of DM could triple the risk of TB.
  
  
  OBJECTIVE
  Within the clinical picture of culture-proven TB, we examined the coexistence of TB, DM, and advanced age in 4 diabetic female elderly patients.
  
  
  METHODS
  Four cases of women with meningitis, bone TB, spondylodiscitis, and meningitis and spondylodiscitis are presented. All patients were diabetic and aged 50 to 79 years. Mycobacterium tuberculosis was isolated from the abscess from lesion areas, cerebrospinal fluid, and synovial fluid samples.
  
  
  CONCLUSIONS
  Presence of DM is known to trigger reactivation of TB. These 4 diabetic female patients are noteworthy because they show that coexistence of DM and TB might lead to progressive forms of extrapulmonary TB in advanced age.
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Haseki Training and Research Hospital, Istanbul, Turkey. kadriyeyasar@hasekihastanesi.gov.tr
authors.forename: Kadriye
authors.initials: K
authors.lastname: Yasar
authors.forename: Filiz
authors.initials: F
authors.lastname: Pehlivanoglu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sengöz
authors.forename: Gonul
authors.initials: G
authors.lastname: Sengoz
mesh_terms: D000367:Age Factors; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D048909:Diabetes Complications / Q000382:microbiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D014390:Tuberculosis, Meningeal / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D014399:Tuberculosis, Spinal / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents