title: Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis.
abstract: BACKGROUND
  8-Oxoguanine DNA glycosylase 1 (OGG1), a key protein involved in the base excision repair pathway, can recognize and excise several lesions from oligodeoxynucleotides with single DNA damage. A C/G polymorphism at 1,245 bp (C1245G) in exon 7 of the OGG1 (Ser326Cys, rs1052133) is found to have a lower enzymatic activity. A variety of case-control studies have been published evaluating the association between OGG1 Ser326Cys polymorphism and colorectal cancer (CRC), though their conclusions were always contradictory.
  
  
  METHODS
  This meta-analysis enrolled 12 studies to estimate the overall risk of OGG1 Ser326Cys polymorphism associated with CRC. The pooled odds ratios (ORs) were performed for codominant model (Cys/Cys versus Ser/Ser; Ser/Cys versus Ser/Ser), dominant model (Ser/Cys + Cys/Cys versus Ser/Ser) and recessive model (Cys/Cys versus Ser/Cys + Ser/Ser).
  
  
  RESULTS
  No significant associations were found for Cys/Cys versus Ser/Ser (OR = 1.19, 95% confidence interval (CI) 0.92-1.53), Ser/Cys versus Ser/Ser (OR = 1.04, 95% CI 0.95-1.13), Ser/Cys + Cys/Cys versus Ser/Ser (OR = 1.06, 95% CI 0.98-1.16) and Cys/Cys versus Ser/Cys + Ser/Ser (OR = 1.11, 95% CI 0.90-1.38); moreover, in the stratified analyses, no significantly increased risk was found for all genetic models.
  
  
  CONCLUSIONS
  Our meta-analysis suggests that the OGG1 Ser326Cys polymorphism is not associated with CRC risk.
authors.affiliation: Clinical Laboratory, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, 215300, Jiangsu Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bang-Shun
authors.initials: BS
authors.lastname: He
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Pan
authors.forename: Ye-Qiong
authors.initials: YQ
authors.lastname: Xu
authors.forename: Shu-Kui
authors.initials: SK
authors.lastname: Wang
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D045647:DNA Glycosylases / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human