title: Association between interleukin 15 receptor, alpha (IL15RA) polymorphism and Korean patients with ossification of the posterior longitudinal ligament.
abstract: OBJECTIVE
  Recently, a number of evidences have been reported concerning the genetic factor involved in the development of ossification of the posterior longitudinal ligament (OPLL). The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the interleukin 15 receptor, alpha (IL15RA) gene as a risk factor in Korean patients with OPLL.
  
  
  METHODS
  To investigate the genetic association, two coding SNPs (rs2296139, Thr73Thr; rs2228059, Asn182Thr) in IL15RA were genotyped in 166 OPLL patients and 230 control subjects. SNPStats, SNPAnalyzer, and Helixtree programs were used for association analysis.
  
  
  RESULTS
  In the present study, we found the association between a missense SNP (rs2228059) and the risk of OPLL in codominant (p = 0.0028, OR = 1.58, 95% CI = 1.17-2.14), dominant (p = 0.0071, OR = 1.82, 95% CI = 1.17-2.82), and recessive models (p = 0.036, OR = 1.79, 95% CI = 1.04-3.09). The frequency of rs2228059 allele was significantly associated with the susceptibility of OPLL (p = 0.0043, OR = 1.52, 95% CI = 1.14-2.02). After Bonferroni correction, the missense SNP (rs2228059, Asn182Thr) still had significant correlations (p = 0.0056 in codominant model; p = 0.0142 in dominant model; p = 0.0086 in allele analysis). Haplotype variation in IL15RA was associated with OPLL (global haplotype test, p = 0.025).
  
  
  CONCLUSIONS
  These results suggest that IL15RA polymorphism may be associated with the susceptibility of OPLL in Korean population.
authors.affiliation: Department of Physical Medicine and Rehabilitation, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Kim
authors.forename: Yong Seol
authors.initials: YS
authors.lastname: Jeong
authors.forename: Jinmann
authors.initials: J
authors.lastname: Chon
authors.forename: Seung Don
authors.initials: SD
authors.lastname: Yoo
authors.forename: Hee-Sang
authors.initials: HS
authors.lastname: Kim
authors.forename: Sung Wook
authors.initials: SW
authors.lastname: Kang
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Ki-Tack
authors.initials: KT
authors.lastname: Kim
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Yun
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017887:Ossification of Posterior Longitudinal Ligament / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D053647:Receptors, Interleukin-15 / Q000097:blood* / Q000235:genetics*; D056910:Republic of Korea; D012307:Risk Factors; D012737:Sex Factors
chemical_list: C508024:IL15RA protein, human; D053647:Receptors, Interleukin-15