title: Imiquimod 5% cream for the treatment of nasal lesion of metastatic renal cell carcinoma.
abstract: Many reports have shown the efficacy of topical imiquimod in patients with skin carcinoma. This effect is based on the activity of imiquimod as an immune-response modifier. The present authors hypothesized that this agent could also be used to treat skin metastatic lesion from renal cell carcinoma. The present authors report the case of a 54-year-old man who presented with a metastasis renal cell carcinoma lesion on his nose. He had a history of right nephrectomy performed 4 years previously. The present authors started him on topical treatment with imiquimod 5% cream three times a week for his nose lesion. A reduction of the lesion was observed after 2 months, and during the following 12 months no sign of recurrence was observed.
authors.affiliation: Department of Dermatology, Kinki Central Hospital, Itami, Hyogo, Japan. asakura_m@kich.itami.hyogo.jp
authors.forename: Makiko
authors.initials: M
authors.lastname: Asakura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miura
mesh_terms: D000279:Administration, Cutaneous; D000634:Aminoquinolines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D000077271:Imiquimod; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D009669:Nose Neoplasms / Q000188:drug therapy* / Q000556:secondary; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000556:secondary; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod