title: [Efficacy of treatment of focal forms of epilepsy in children with antiepileptic drugs of different generations].
abstract: An aim was to study the efficacy of different groups of antiepileptic drugs in the treatment of focal symptomatic (or probably symptomatic) epilepsy in children. The study included 96 patients, aged from 1 month to 17 years, 55 boys and 41 girls. They were stratified into three groups by drug type: group 1 (34 patients) was treated with phenobarbital, group 2 (31 patients) received topiramate and group 3 (31 patients) received lamotrigine. It has been shown that antiepileptic drugs of the new generation have higher efficacy with regard to focal forms of epilepsy in children compared to phenobarbital. However therapeutic effect, especially regarding seizure frequency, was specific for each drug.
authors.forename: S N
authors.initials: SN
authors.lastname: Sivkova
authors.forename: K Iu
authors.initials: KIu
authors.lastname: Mukhin
authors.forename: F M
authors.initials: FM
authors.lastname: Zaĭkova
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D000077213:Lamotrigine; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D000077236:Topiramate; D016896:Treatment Outcome; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077236:Topiramate; D005632:Fructose; D000077213:Lamotrigine; D010634:Phenobarbital