title: Effect of an anesthesia with propofol compared with desflurane on free radical production and liver function after partial hepatectomy.
abstract: Propofol has shown antioxidant properties, but no study has focused on liver resection surgery. The aim of this study was to investigate the effect of an anesthesia with propofol compared with desflurane on oxidative stress and hepatic function during and after partial hepatectomy. This was a prospective randomized study performed on two parallel groups. The primary endpoint was malondialdehyde (MDA) plasma concentration 30 min after hepatic vascular unclamping. Hepatic damages were evaluated by plasma levels of alpha-glutathione S-transferase (α-GST) 120 min after hepatic vascular unclamping and of aminotransferases at 120 min and on days 1, 2, 5, and 10. Liver function recovery was assessed by monoethylglycinexylidide (MEGX) formation 15 min after lidocaine injection on day 2 and by prothrombin time and plasma factor V at 120 min and on days 1, 2, 5, and 10. Thirty patients were analyzed (propofol group: 17; desflurane group: 13). There was no significant difference between groups for MDA plasma concentration 30 min after hepatic vascular unclamping (mean ± standard-deviation: 1.28 ± 0.40 and 1.21 ± 0.29 in propofol and desflurane groups, respectively, P = 0.608). Plasma levels of α-GST at 120 min were lower in propofol than in desflurane group (142.2 ± 75.4 vs. 205.7 ± 66.5, P = 0.023), and MEGX on day 2 was higher (0.092 ± 0.096 vs. 0.036 ± 0.020, P = 0.007). No differences between groups were observed with regard to plasma levels of aminotransferases, prothrombin time, and plasma factor V. Our study showed that in patients undergoing partial hepatectomy, propofol did not reduce MDA formation but seemed to display a protective effect on hepatic damages and liver function when compared to desflurane.
authors.affiliation: Service de Pharmacologie Clinique, Hôpital de Pontchaillou, CHU de Rennes, Université de Rennes 1, 35033 Rennes Cedex, France. bruno.laviolle@chu-rennes.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Laviolle
authors.forename: Cédric
authors.initials: C
authors.lastname: Basquin
authors.forename: David
authors.initials: D
authors.lastname: Aguillon
authors.forename: Philippe
authors.initials: P
authors.lastname: Compagnon
authors.forename: Isabelle
authors.initials: I
authors.lastname: Morel
authors.forename: Valérie
authors.initials: V
authors.lastname: Turmel
authors.forename: Philippe
authors.initials: P
authors.lastname: Seguin
authors.forename: Karim
authors.initials: K
authors.lastname: Boudjema
authors.forename: Eric
authors.initials: E
authors.lastname: Bellissant
authors.forename: Yannick
authors.initials: Y
authors.lastname: Mallédant
mesh_terms: D000368:Aged; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000077335:Desflurane; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D008012:Lidocaine / Q000031:analogs & derivatives / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000601:surgery; D008111:Liver Function Tests; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies; D020127:Recovery of Function; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D005609:Free Radicals; D008315:Malondialdehyde; D008012:Lidocaine; D000077335:Desflurane; D007530:Isoflurane; C001173:monoethylglycinexylidide; D015742:Propofol