title: Effect of endoscopic sinus surgery on pulmonary function and microbial pathogens in a pediatric population with cystic fibrosis.
abstract: OBJECTIVE
  To assess whether improvements in pulmonary function and microbial pathogenic findings can be achieved by endoscopic sinus surgery in a pediatric population with cystic fibrosis.
  
  
  METHODS
  Retrospective medical record review.
  
  
  METHODS
  Academic research.
  
  
  METHODS
  Forty-one patients with cystic fibrosis who had undergone endoscopic sinus surgery at a single tertiary academic pediatric otolaryngology practice.
  
  
  METHODS
  Changes in pulmonary function test values or respiratory tract microbial pathogens after endoscopic sinus surgery were examined.
  
  
  RESULTS
  Endoscopic sinus surgery did not improve pulmonary function test results in this population. Examination of respiratory tract microbial colonization showed that endoscopic sinus surgery did not affect microbial pathogens. The most common organisms isolated were Staphylococcus aureus and Pseudomonas aeruginosa.
  
  
  CONCLUSIONS
  The lack of effect of endoscopic sinus surgery on pulmonary function test results and respiratory tract microbial pathogens in our study highlights the need for prospective assessments of postoperative quality-of-life improvement and of adjunct medical therapy efficacy.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Hospital for Sick Children, ON, Canada.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Osborn
authors.forename: Randy
authors.initials: R
authors.lastname: Leung
authors.forename: Felix
authors.initials: F
authors.lastname: Ratjen
authors.forename: Adrian L
authors.initials: AL
authors.lastname: James
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000382:microbiology / Q000503:physiopathology*; D004724:Endoscopy; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D008297:Male; D003904:Mitosporic Fungi / Q000302:isolation & purification; D009298:Nasal Polyps / Q000601:surgery; D010256:Paranasal Sinuses / Q000601:surgery*; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000382:microbiology*; D012189:Retrospective Studies; D012220:Rhinitis / Q000601:surgery; D012852:Sinusitis / Q000601:surgery