title: DNA methylation at H19/IGF2 ICR1 in the placenta of pregnancies conceived by in vitro fertilization and intracytoplasmic sperm injection.
abstract: DNA methylation at H19 ICR1 was investigated in the placenta from pregnancies conceived by in vitro fertilization, intracytoplasmic sperm injection, and from natural conception. Our results showed that there were no significant differences in mean methylation between all pregnancy groups; therefore, assisted reproductive technology may not affect proper imprinting of H19 and IGF2.
authors.affiliation: Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Edgar Chan
authors.initials: EC
authors.lastname: Wong
authors.forename: Chiho
authors.initials: C
authors.lastname: Hatakeyama
authors.forename: Wendy P
authors.initials: WP
authors.lastname: Robinson
authors.forename: Sai
authors.initials: S
authors.lastname: Ma
mesh_terms: D000328:Adult; D001955:British Columbia; D019175:DNA Methylation; D005260:Female; D005307:Fertilization in Vitro; D005317:Fetal Growth Retardation / Q000235:genetics; D018392:Genomic Imprinting; D005865:Gestational Age; D006657:Histones; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008297:Male; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D006657:Histones; C035170:IGF2 protein, human; D007335:Insulin-Like Growth Factor II