title: Comparative immunohistochemical study of multicystic dysplastic kidneys with and without obstruction.
abstract: Etiology of multicystic dysplastic kidney (MCDK) remains unknown. Not all cases are associated with obstruction. We compared by immunohistochemistry 17 cases of MCDK (10 cases with and seven without obstruction) to 17 controls and 20 fetal kidneys. TGF-β was negative in obstructive MCDKs and positive in nonobstructive MCDK. IGF2 was overexpressed in obstructive and underexpressed in nonobstructive MCDKs. PAX2, BCL-2, and β-catenin were expressed equally in obstructive and nonobstructive dysplasia. TGF-β and IGF2 work by different mechanisms in obstructive and nonobstructive MCDKs, but there are no differences among PAX 2, BCL-2, and β-catenin in obstructive versus nonobstructive dysplasia.
authors.affiliation: Department of Pathology, University of Miami, Holtz's Children's Hospital, Miami, Florida 33136, USA.
authors.forename: Claudia P
authors.initials: CP
authors.lastname: Rojas
authors.forename: Arnel K
authors.initials: AK
authors.lastname: Urbiztondo
authors.forename: Jocelyn H
authors.initials: JH
authors.lastname: Bruce
authors.forename: Maria M
authors.initials: MM
authors.lastname: Rodriguez
mesh_terms: D001344:Autopsy; D005260:Female; D005333:Fetus / Q000378:metabolism / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D007668:Kidney / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D021782:Multicystic Dysplastic Kidney / Q000378:metabolism* / Q000473:pathology*; D051762:PAX2 Transcription Factor / Q000378:metabolism; D011247:Pregnancy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D012189:Retrospective Studies; D016212:Transforming Growth Factor beta / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
chemical_list: C035170:IGF2 protein, human; D051762:PAX2 Transcription Factor; D019253:Proto-Oncogene Proteins c-bcl-2; D016212:Transforming Growth Factor beta; D051176:beta Catenin; D007335:Insulin-Like Growth Factor II