title: The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema.
abstract: OBJECTIVE
  To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME).
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness.
  
  
  RESULTS
  Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm.
  
  
  CONCLUSIONS
  In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.
authors.affiliation: Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Elham
authors.initials: E
authors.lastname: Hatef
authors.affiliation: Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Colantuoni
authors.affiliation: Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Ophthalmology, The Second Hospital of Hebei Medical University Shijiazhuang, Hebei Province, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ibrahim
authors.affiliation: Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Matthew
authors.initials: M
authors.lastname: Shulman
authors.affiliation: Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Fatima
authors.initials: F
authors.lastname: Adhi
authors.affiliation: Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Yasir Jamal
authors.initials: YJ
authors.lastname: Sepah
authors.affiliation: Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Roomasa
authors.initials: R
authors.lastname: Channa
authors.affiliation: Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Afsheen
authors.initials: A
authors.lastname: Khwaja
authors.affiliation: Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Quan Dong
authors.initials: QD
authors.lastname: Nguyen
authors.affiliation: Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: ddo@jhmi.edu.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Do
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D005403:Fixation, Ocular / Q000502:physiology; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008269:Macular Edema / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human