title: Biokinetics of 90Sr after chronic ingestion in a juvenile and adult mouse model.
abstract: The aim of our study was to define the biokinetics of (90)Sr after chronic contamination by ingestion using a juvenile and adult murine model. Animals ingested (90)Sr by drinking water containing 20 kBq l(-1) of (90)Sr. For the juvenile model, parents received (90)Sr before mating and their offspring were killed between birth and 20 weeks of ingestion. For the adult model, (90)Sr ingestion started at 9 weeks of age and they were killed after different ingestion periods up to 20 weeks. The body weight, food and water consumption of the animals were monitored on a weekly basis. Before killing and sampling of organs, animals were put in metabolic cages. (90)Sr in organs and excreta was determined by liquid scintillation β counting. Highest (90)Sr contents were found in bones and were generally higher in females than in males, and (90)Sr retention varied according to the skeletal sites. An accumulation of (90)Sr in the bones was observed over time for both models, with a plateau level at adult age for the juvenile model. The highest rate of (90)Sr accumulation in bones was observed in early life of offspring, i.e. before the age of 6 weeks. With the exception of the digestive tract, (90)Sr was below the detection limit in all other organs sampled. Overall, our results confirm that (90)Sr mainly accumulates in bones. Furthermore, our results indicate that there are gender- and age-dependent differences in the distribution of (90)Sr after low-dose chronic ingestion in the mouse model. These results provide the basis for future studies on possible non-cancerous effects during chronic, long-term exposure to (90)Sr through ingestion in a mouse model, especially on the immune and hematopoietic systems.
authors.affiliation: Institut de Radioprotection et Sûreté Nucléaire (IRSN), DRPH, SRBE, LRTOX, Fontenay-aux-Roses, France.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Synhaeve
authors.forename: Johanna
authors.initials: J
authors.lastname: Stefani
authors.forename: Elie
authors.initials: E
authors.lastname: Tourlonias
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dublineau
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Bertho
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D004326:Drinking; D060766:Drinking Water; D005260:Female; D008297:Male; D051379:Mice; D023421:Models, Animal; D012727:Sex Characteristics; D013326:Strontium Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D013997:Time Factors; D014875:Water Pollutants, Radioactive / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D060766:Drinking Water; D013326:Strontium Radioisotopes; D014875:Water Pollutants, Radioactive