title: The significance of isolated Y chromosome loss in bone marrow metaphase cells from males over age 50 years.
abstract: To further investigate the potential clinical significance of Y chromosome loss as the sole bone marrow karyotype change, we studied 161 Mayo Clinic male patients with 75% or more metaphase cells with Y loss, and correlated the percent Y loss with age and hematopathologic review. In patients with a lymphoproliferative or plasma cell disorder, the negligible proportion of bone marrow involvement cannot account for the observed high proportion of -Y cells. In males with myeloid disease, Y loss appears to often represent the abnormal myeloid clone, which may also harbor acquired genetic changes that are not observed by conventional cytogenetic analysis.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Wiktor
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Van Dyke
authors.forename: Janice M
authors.initials: JM
authors.lastname: Hodnefield
authors.forename: Jeanette
authors.initials: J
authors.lastname: Eckel-Passow
authors.forename: Curtis A
authors.initials: CA
authors.lastname: Hanson
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells / Q000473:pathology; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008677:Metaphase / Q000235:genetics*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D012189:Retrospective Studies