title: Dynamic postprandial hepatic stiffness augmentation assessed with MR elastography in patients with chronic liver disease.
abstract: OBJECTIVE
  MR elastography (MRE) is an MRI-based technique for quantitatively assessing tissue stiffness by studying shear wave propagation through tissue. The goal of this study was to test the hypothesis that hepatic MRE performed before and after a meal will result in a postprandial increase in hepatic stiffness among patients with hepatic fibrosis because of transiently increased portal pressure.
  
  
  METHODS
  Twenty healthy volunteers and 25 patients with biopsyproven hepatic fibrosis were evaluated. Preprandial MRE measurements were performed after overnight fasting. A liquid test meal was administered, and 30 minutes later a postprandial MRE acquisition was performed. Identical imaging parameters and analysis regions of interest were used for pre- and postprandial acquisitions.
  
  
  RESULTS
  The results in the 20 subjects without liver disease showed a mean stiffness change of 0.16 ± 0.20 kPa (range, -0.12 to 0.78 kPa) or 8.08% ± 10.33% (range, -5.36% to 41.7%). The hepatic stiffness obtained in the 25 patients with hepatic fibrosis showed a statistically significant increase in postprandial liver stiffness, with mean augmentation of 0.89 ± 0.96 kPa (range, 0.17-4.15 kPa) or 21.24% ± 14.98% (range, 7.69%-63.3%).
  
  
  CONCLUSIONS
  MRE-assessed hepatic stiffness elevation in patients with chronic liver disease has two major components: a static component reflecting structural change or fibrosis and a dynamic component reflecting portal pressure that can increase after a meal. These findings will provide motivation for further studies to determine the potential value of assessing postprandial hepatic stiffness augmentation for predicting the progression of fibrotic disease and the development of portal hypertension. The technique may also provide new insights into the natural history and pathophysiology of chronic liver disease.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA. yin.meng@mayo.edu
authors.forename: Meng
authors.initials: M
authors.lastname: Yin
authors.forename: Jayant A
authors.initials: JA
authors.lastname: Talwalkar
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Glaser
authors.forename: Sudhakar K
authors.initials: SK
authors.lastname: Venkatesh
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Armando
authors.initials: A
authors.lastname: Manduca
authors.forename: Richard L
authors.initials: RL
authors.lastname: Ehman
mesh_terms: D000328:Adult; D000368:Aged; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult