title: Serum levels of HSP90 in the continuum of breast ductal and lobular lesions.
abstract: BACKGROUND
  Heat-shock protein 90 (HSP90) is an abundant protein in mammalian cells. It interacts with a variety of proteins that play key roles in breast neoplasia. This is the first study to assess serum levels of HSP90 in atypical ductal hyperplasia (ADH), lobular neoplasia (LN), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and infiltrative lobular carcinoma (ILC).
  
  
  METHODS
  Serum concentrations of HSP90 in women with benign (n=34), ADH (n=26), DCIS (n=30), IDC (n=29), LN (n=20) and ILC (n=9) lesions were determined with immunoenzymatic assays. For the evaluation of serum concentrations along the transition from benign through precursor and preinvasive to invasive lesion, the severity of diagnosis was treated as an ordinal variable.
  
  
  RESULTS
  No significant association was demonstrated between serum HSP90 levels and the severity of the lesion in ductal and lobular series. The post hoc comparison between the lobular and ductal precursor lesions (i.e. ADH vs. LN) did not yield a statistically significant difference. Similarly, the post hoc comparison between the lobular and ductal invasive carcinomas (i.e. IDC vs. ILC) did not point to a statistically significant difference.
  
  
  CONCLUSIONS
  This is the first study evaluating HSP90 serum levels in both lobular and ductal lesions of the breast. Contrary to published pathological findings according to which HSP90 exhibits significant variability along both series, such a finding was not replicated for the level of serum HSP90 concentrations.
authors.affiliation: Breast Unit, First Department of Propaedeutic Surgery, Hippokratio Hospital, School of Medicine, University of Athens, Greece.
authors.forename: Flora
authors.initials: F
authors.lastname: Zagouri
authors.forename: Theodoros N
authors.initials: TN
authors.lastname: Sergentanis
authors.forename: Xeni
authors.initials: X
authors.lastname: Provatopoulou
authors.forename: Eleni
authors.initials: E
authors.lastname: Kalogera
authors.forename: Dimosthenis
authors.initials: D
authors.lastname: Chrysikos
authors.forename: Maria
authors.initials: M
authors.lastname: Lymperi
authors.forename: Christos A
authors.initials: CA
authors.lastname: Papadimitriou
authors.forename: Eleni
authors.initials: E
authors.lastname: Zografos
authors.forename: Garifallia
authors.initials: G
authors.lastname: Bletsa
authors.forename: Vasileios S
authors.initials: VS
authors.lastname: Kalles
authors.forename: George C
authors.initials: GC
authors.lastname: Zografos
authors.forename: Antonia
authors.initials: A
authors.lastname: Gounaris
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001941:Breast Diseases / Q000097:blood* / Q000473:pathology*; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000097:blood / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000097:blood / Q000473:pathology; D018275:Carcinoma, Lobular / Q000097:blood / Q000473:pathology; D005260:Female; D018841:HSP90 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D006965:Hyperplasia / Q000097:blood / Q000473:pathology; D008875:Middle Aged
chemical_list: D018841:HSP90 Heat-Shock Proteins