title: Genetic engineering of a mouse: Dr. Frank Ruddle and somatic cell genetics.
abstract: Genetic engineering is the process of modifying an organism's genetic composition by adding foreign genes to produce desired traits or evaluate function. Dr. Jon W. Gordon and Sterling Professor Emeritus at Yale Dr. Frank H. Ruddle were pioneers in mammalian gene transfer research. Their research resulted in production of the first transgenic animals, which contained foreign DNA that was passed on to offspring. Transgenic mice have revolutionized biology, medicine, and biotechnology in the 21st century. In brief, this review revisits their creation of transgenic mice and discusses a few evolving applications of their transgenic technology used in biomedical research.
authors.affiliation: Department of Immunobiology, Yale School of Medicine, 10 Amistad Street, New Haven, CT 06519, USA. dennis.jones@yale.edu
authors.forename: Dennis
authors.initials: D
authors.lastname: Jones
mesh_terms: D000818:Animals; D005818:Genetic Engineering / Q000266:history* / Q000379:methods; D005823:Genetics / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D051379:Mice; D008822:Mice, Transgenic