title: One hundred percent three-year graft and patient survival: kidney transplantation at Saint Joseph Hospital of Orange.
abstract: We report 99 consecutive renal transplants between 7/1/04 and 6/30/07 with 100% 3-year graft survival, statistically higher than expected per the SRTR (p < 0.01). Ninety-eight patients had antibody induction of immunosuppression with either daclizumab (n = 52) or Thymoglobulin (n = 46). Steroids were minimized with nearly all patients tapered to prednisone 5 mg by discharge. Sixteen patients experienced early rejection. Twelve of the rejections were in 85 patients who received ABO compatible first transplants. Of these 12 rejections, 11 occurred in patients who had been induced with daclizumab and one with Thymoglobulin (p = 0.01). Immunosuppression, infection prophylaxis and surveillance, and all medical and social issues potentially impacting graft or patient survival were managed by the transplant center for the first year minimum, and as long as clinically indicated post-transplant. Patients were educated to have all subsequent medical and social issues triaged by the transplant center for the life of the transplant.
authors.affiliation: Kidney Transplant Program, Saint Joseph Hospital of Orange, Orange, CA, USA.
authors.forename: Ervin P
authors.initials: EP
authors.lastname: Ruzics
authors.forename: Marlene
authors.initials: M
authors.lastname: Abe
authors.forename: Wendy
authors.initials: W
authors.lastname: Escobedo
authors.forename: Paula
authors.initials: P
authors.lastname: Gull
authors.forename: Marya
authors.initials: M
authors.lastname: Weil
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002140:California; D002648:Child; D005260:Female; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects; D006764:Hospitals, Community; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016730:Program Development; D015397:Program Evaluation; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors; D023001:Transplantation Tolerance; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents