title: Biological basis of exercise-based treatments: spinal cord injury.
abstract: Despite intensive neurorehabilitation, extensive functional recovery after spinal cord injury is unattainable for most individuals. Optimal recovery will likely depend on activity-based, task-specific training that personalizes the timing of intervention with the severity of injury. Exercise paradigms elicit both beneficial and deleterious biophysical effects after spinal cord injury. Modulating the type, intensity, complexity, and timing of training may minimize risk and induce greater recovery. This review discusses the following: (a) the biological underpinning of training paradigms that promote motor relearning and recovery, and (b) how exercise interacts with cellular cascades after spinal cord injury. Clinical implications are discussed throughout.
authors.affiliation: Center for Brain and Spinal Cord Repair, School of Allied Medical Professions, The Ohio State University, 106 Atwell Hall, 453 W 10th Ave, Columbus, OH 43210, USA.
authors.forename: D
authors.initials: D
authors.lastname: Michele Basso
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Hansen
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000503:physiopathology / Q000534:rehabilitation
chemical_list: D015415:Biomarkers