title: Bioactive and osteoinductive bone graft substitutes: definitions, facts and myths.
abstract: The use of artificial bone grafts has been developed over recent years and is expected to increase further, for some indications even replacing the gold standard, autograft, in trauma and reconstructive surgery. However, the effectiveness of these materials is still a subject of debate, mostly because of unclear definitions or limited market surveillance. In this overview several facts and myths regarding bone-graft substitutes are summarized.
authors.affiliation: University Medical Centre Utrecht, Heidelberglaan 100, PO Box 85500, Utrecht, The Netherlands. t.j.blokhuis@umcutrecht.nl
authors.forename: T J
authors.initials: TJ
authors.lastname: Blokhuis
authors.forename: J J Chris
authors.initials: JJ
authors.lastname: Arts
mesh_terms: D001857:Bone Matrix; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D016025:Bone Transplantation; D002130:Calcium Phosphates / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D010012:Osteogenesis; D014182:Transplantation, Autologous / Q000295:instrumentation; D014184:Transplantation, Homologous / Q000295:instrumentation
chemical_list: D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D002130:Calcium Phosphates