title: Efficacy of dinotefuran-pyriproxyfen, dinotefuran-pyriproxyfen-permethrin and fipronil-(S)-methoprene topical spot-on formulations to control flea populations in naturally infested pets and private residences in Tampa, FL.
abstract: Thirteen cats and 7 dogs living in 14 homes were treated topically with either a dinotefuran (22%, w/w)/pyriproxyfen (3.00%, w/w) (DP) or dinotefuran (4.95%, w/w)/pyriproxyfen (0.44%, w/w)/permethrin (36.08%, w/w) (DPP) topical spot-on, respectively. Twenty cats and 7 dogs living in 16 homes were treated topically with either a fipronil (9.8%, w/w)/(S)-methoprene (11.8%, w/w) or fipronil (9.8%, w/w)/(S)-methoprene (8.8%, w/w) topical spot-on (FM), respectively. All products were applied according to label directions by study investigators on day 0 and again between days 28 and 30. Flea populations on pets were assessed using visual area counts and premise flea infestations were assessed using intermittent-light flea traps on days 0, 7, 14, 21, 28-30, 40-45, and 54-60. A single application of the DP-DPP and FM formations reduced flea populations by 87.35% and 88.44%, respectively within 7 days. Following two monthly applications of either the DP-DPP or FM formulations, pet flea burdens were reduced by 95.24% and 95.47%, respectively. Flea numbers in the indoor-premises were also markedly reduced by days 54-60, with 98.05% and 96.15% reductions in intermittent-light flea trap counts in the DP-DPP or FM treatment groups, respectively.
authors.affiliation: Dept. of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA. dryden@vet.ksu.edu
authors.forename: Michael W
authors.initials: MW
authors.lastname: Dryden
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Payne
authors.forename: Smith
authors.initials: S
authors.lastname: Vicki
authors.forename: Breanne
authors.initials: B
authors.lastname: Riggs
authors.forename: Jacob
authors.initials: J
authors.lastname: Davenport
authors.forename: Denise
authors.initials: D
authors.lastname: Kobuszewski
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002371:Cat Diseases / Q000453:epidemiology / Q000517:prevention & control*; D002415:Cats; D004283:Dog Diseases / Q000453:epidemiology / Q000517:prevention & control*; D004285:Dogs; D058267:Flea Infestations / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D005431:Florida / Q000453:epidemiology; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use; D006798:Housing; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D008726:Methoprene / Q000008:administration & dosage / Q000627:therapeutic use; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D026023:Permethrin / Q000008:administration & dosage / Q000627:therapeutic use; D057805:Pets; D011720:Pyrazoles / Q000008:administration & dosage / Q000627:therapeutic use; D011725:Pyridines / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D006146:Guanidines; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011720:Pyrazoles; D011725:Pyridines; C465368:dinotefuran; C055613:pyriproxyfen; D026023:Permethrin; D008726:Methoprene; C082360:fipronil