title: Preparation and influencing factors of sirolimus liposome by supercritical fluid.
abstract: We prepared the sirolimus liposome by rapid expansion of supercritical solution (RESS) technology of supercritical fluid, and studied the effects of temperature, pressure, and equilibrium time on the average particle size and envelop rate of liposome. The conditions of the minimal average particle size of liposome were 328K of temperature (35MPa), 35MPa of pressure (333K), and 50 minutes of equilibrium (343K) time, respectively. The conditions of the maximal envelop rate of liposome were 333K of temperature (30MPa), 35MPa of pressure (343K), and 50 minutes of equilibrium (323K) time, respectively.
authors.affiliation: Faculty of Pharmacy, Medical College, Qingdao University, Qingdao City, Shandong, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Li
authors.forename: Ruowu
authors.initials: R
authors.lastname: Shen
authors.forename: Hongli
authors.initials: H
authors.lastname: Ni
authors.forename: Dejian
authors.initials: D
authors.lastname: Hu
mesh_terms: D005740:Gases / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D055616:Microtechnology / Q000379:methods*; D010316:Particle Size; D011312:Pressure; D020123:Sirolimus / Q000008:administration & dosage*; D013696:Temperature; D013997:Time Factors
chemical_list: D005740:Gases; D008081:Liposomes; D020123:Sirolimus