title: Single center experience on talc poudrage morbidity: focus on high talc dosage.
abstract: Malignant pleural effusion (MPE) is a common clinical problem of concern for most of the pneumologists and thoracic surgeons. A general consensus regarding the use of talc poudrage in treatment of MPE exists, but only few studies analyzed in detail talc insufflation related pulmonary morbidity. In particular, ARDS talc-related is caused by physical and chemical effects of the small talc particles (50% particle size <15 μm) and its occurrence is independent from the underlying disease, the quantity of talc used or the technique of talc instillation. In our series we observed 3 cases only (0.75%) of talc-related lung injury. This data strongly confirm the low rate of talc-related lung injury after talc poudrage in treatment of MPE regardless the amount of talc insufflated.
authors.affiliation: Department of Thoracic Surgery, Catholic University of Sacred Heart, Rome, Italy. gio.leuzzi@yahoo.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Leuzzi
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Vita
authors.forename: Venanzio
authors.initials: V
authors.lastname: Porziella
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Congedo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cesario
mesh_terms: D006801:Humans; D007509:Irritants / Q000008:administration & dosage / Q000009:adverse effects*; D055370:Lung Injury / Q000209:etiology*; D016066:Pleural Effusion, Malignant / Q000601:surgery*; D018700:Pleurodesis / Q000379:methods; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D013627:Talc / Q000008:administration & dosage / Q000009:adverse effects*; D013906:Thoracoscopy
chemical_list: D007509:Irritants; D013627:Talc