title: New advanced glycation end-products inhibitors from Dichrostachys cinerea Wight & Arn.
abstract: Free radical scavenging and advanced glycation end-product (AGE) inhibitory potential were evaluated in the crude methanol extract of Dichrostachys cinerea. Bioassay-guided isolation led to the identification of four flavan-3-ols, namely (-)-mesquitol (1), oritin (2), (-)-festidinol (3) and (-)-epicatechin (4). Analysis of structure-activity relationships revealed that the presence of 7,8-dihydroxyl groups in the A-ring of flavan-3-ols in conjunction with 3',4'-dihydroxyls in the B-ring (1) is an important criterion for displaying potent AGE inhibitory activity along with free radical scavenging properties. (-)-Mesquitol (1), oritin (2), and (-)-festidinol (3) were found to be new natural AGE inhibitors. (-)-Mesquitol (1) displayed the most potent AGE inhibitory activity. Results suggest that (-)-mesquitol (1) may serve as an important natural organic lead compound for future development of antiglycating agents along with potent antioxidant activity.
authors.affiliation: Division of Organic Chemistry-I, Natural Product Laboratory, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
authors.forename: G
authors.initials: G
authors.lastname: Suresh
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Tiwari
authors.forename: M
authors.initials: M
authors.lastname: Radha Krishna Murthy
authors.forename: D
authors.initials: D
authors.lastname: Anand Kumar
authors.forename: K
authors.initials: K
authors.lastname: Rajendra Prasad
authors.forename: R
authors.initials: R
authors.lastname: Ranga Rao
authors.forename: A
authors.initials: A
authors.lastname: Zehra Ali
authors.forename: K
authors.initials: K
authors.lastname: Suresh Babu
mesh_terms: D004305:Dose-Response Relationship, Drug; D007887:Fabaceae / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D016166:Free Radical Scavengers; D017127:Glycation End Products, Advanced; D010936:Plant Extracts; D012997:Solvents; D000432:Methanol