title: Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action.
authors.affiliation: Department of Chemistry, University of Liverpool, Crown St., Liverpool L697ZD, UK.
authors.forename: James
authors.initials: J
authors.lastname: Chadwick
authors.forename: Richard K
authors.initials: RK
authors.lastname: Amewu
authors.forename: Francesc
authors.initials: F
authors.lastname: Marti
authors.forename: Fatima Bousejra-El
authors.initials: FB
authors.lastname: Garah
authors.forename: Raman
authors.initials: R
authors.lastname: Sharma
authors.forename: Neil G
authors.initials: NG
authors.lastname: Berry
authors.forename: Paul A
authors.initials: PA
authors.lastname: Stocks
authors.forename: Hollie
authors.initials: H
authors.lastname: Burrell-Saward
authors.forename: Sergio
authors.initials: S
authors.lastname: Wittlin
authors.forename: Matthias
authors.initials: M
authors.lastname: Rottmann
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Donatella
authors.initials: D
authors.lastname: Taramelli
authors.forename: Silvia
authors.initials: S
authors.lastname: Parapini
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Ward
authors.forename: Paul M
authors.initials: PM
authors.lastname: O'Neill
mesh_terms: D000284:Administration, Oral; D000655:Amodiaquine / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006420:Hemeproteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D006427:Hemin / Q000737:chemistry; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008352:Mannich Bases / Q000737:chemistry; D051379:Mice; D056004:Molecular Dynamics Simulation; D010545:Peroxides / Q000737:chemistry; D010636:Phenols / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D013141:Spiro Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship; D045568:Tetraoxanes / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D006420:Hemeproteins; D008352:Mannich Bases; D010545:Peroxides; D010636:Phenols; C554719:RKA 182; D013141:Spiro Compounds; D045568:Tetraoxanes; D000655:Amodiaquine; C020753:hemozoin; D006427:Hemin