title: Polymorphisms in isoniazid and prothionamide resistance genes of the Mycobacterium tuberculosis complex.
abstract: Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.
authors.affiliation: Molecular Mycobacteriology, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Projahn
authors.forename: Claudio U
authors.initials: CU
authors.lastname: Köser
authors.forename: Susanne
authors.initials: S
authors.lastname: Homolka
authors.forename: David K
authors.initials: DK
authors.lastname: Summers
authors.forename: John A C
authors.initials: JA
authors.lastname: Archer
authors.forename: Stefan
authors.initials: S
authors.lastname: Niemann
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D007538:Isoniazid / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011515:Prothionamide / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D011515:Prothionamide; D007538:Isoniazid