title: Genetic polymorphism analysis of killer cell immunoglobulin-like receptor genes in the Chinese Uygur population.
abstract: Human killer cell immunoglobulin-like receptors are expressed in natural killer cells and subsets of T lymphocytes. They regulate these cells upon interaction with human leukocyte antigen class I molecules and other ligands presented by target cells. KIR gene frequencies and haplotype distributions have been shown to differ significantly between populations from different geographical regions and ethnic origins, which relates to functional variations in the immune response. We have investigated KIR gene frequencies and genotype diversities of 15 KIR genes (KIR2DL1, 2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 2DS3, 2DS4, ID, 2DS5, 3DL1, 3DL2, 3DL3, 3DS1) and two pseudogenes (KIR3DP1 and 2DP1) in 120 unrelated healthy individuals of the Uygur population living in the Xinjiang autonomous region of China. All individuals were typed positive for the four framework loci KIR3DL3, 2DL4, 3DL2 and KIR3DP1, while activating genes (KIR2DS1, 2DS2, 2DS3, 2DS5 and KIR3DS1) indicated some variation in this population. KIR3DS1 was found in a higher frequency in the studied population than in other groups from China. Linkage disequilibrium among KIR genes displayed a wide range. χ(2) analysis, conducted among non-ubiquitous genes, based on the KIR gene frequency data from our study population and previously published population data, revealed significant differences in the KIR2DL1, 2DL2, 2DL3, 2DL5, 3DL1, 2DS1, 2DS2, 2DS3, 2DS5, and 3DS1 genes. A neighbor-joining phylogenic tree, built using the observed carrier frequencies data of 13 KIR loci (KIR2DL1, 2DL2, 2DL3, 2DL4, 2DL5, 3DL1, 3DL2, 3DL3, 2DS1, 2DS2, 2DS3, 2DS5, and 3DS1), showed relationships between the population studied and other previously reported populations. The present study can therefore be valuable for enriching the ethnical gene information resources of the KIR gene pool, for population origin studies and for KIR-related clinical practice.
authors.affiliation: The Key Laboratory of Environment and Disease Related Genes, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.
authors.forename: Hong-dan
authors.initials: HD
authors.lastname: Wang
authors.forename: Bo-feng
authors.initials: BF
authors.lastname: Zhu
authors.forename: Chun-mei
authors.initials: CM
authors.lastname: Shen
authors.forename: Guo-lian
authors.initials: GL
authors.lastname: Yuan
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Juan-ning
authors.initials: JN
authors.lastname: Guo
authors.forename: Jiang-wei
authors.initials: JW
authors.lastname: Yan
authors.forename: Hai-xia
authors.initials: HX
authors.lastname: Qin
authors.forename: Jian-xin
authors.initials: JX
authors.lastname: Guo
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Zhang
authors.forename: Xiao-qin
authors.initials: XQ
authors.lastname: Jia
authors.forename: Rudolf
authors.initials: R
authors.lastname: Lucas
mesh_terms: D002681:China; D016000:Cluster Analysis; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D021141:Nucleic Acid Amplification Techniques; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D054340:Receptors, KIR / Q000145:classification / Q000235:genetics*
chemical_list: D054340:Receptors, KIR