title: Nonfouling Polypeptide Brushes via Surface-initiated Polymerization of N(ε) -oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride.
abstract: This contribution describes the preparation of nonfouling polypeptide brushes via surface-initiated ring-opening polymerization of oligo(ethylene glycol) modified L-lysine N-carboxyanhydrides. Circular dichroism experiments indicated that these surface-anchored polypeptide chains assume an α-helical conformation, which does not change between pH 4 and 9. Furthermore, nonspecific adsorption of fluorescent labeled bovine serum albumin and fibrinogen on glass slides modified with these brushes was greatly reduced compared to unmodified glass substrates.
authors.affiliation: École Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux, Laboratoire des Polymères, Bâtiment MXD, Station 12, CH-1015 Lausanne, Switzerland; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Matthew I
authors.initials: MI
authors.lastname: Gibson
authors.forename: Raphaël
authors.initials: R
authors.lastname: Barbey
authors.forename: Shou-Jun
authors.initials: SJ
authors.lastname: Xiao
authors.forename: Harm-Anton
authors.initials: HA
authors.lastname: Klok