title: Mitochondrial impact of human immunodeficiency virus and antiretrovirals on infected pediatric patients with or without lipodystrophy.
abstract: We determined the mitochondrial status of a group of HIV-infected children, some with body fat abnormalities (BFA). We included 24 controls, 16 HIV-infected untreated, 26 HIV-infected treated, 6 BFA-untreated, and 21 BFA-treated patients. Genetic, translational, and functional mitochondrial values were measured. As compared with controls, mitochondrial DNA depletion and a reduction in functionality were found in BFA groups.
authors.affiliation: Mitochondrial Functionalism Laboratory, University of Barcelona, IDIBAPS, Hospital Clínic of Barcelona, Barcelona, Spain. cmoren1@clinic.ub.es
authors.forename: Constanza
authors.initials: C
authors.lastname: Morén
authors.forename: Antoni
authors.initials: A
authors.lastname: Noguera-Julian
authors.forename: Núria
authors.initials: N
authors.lastname: Rovira
authors.forename: Ester
authors.initials: E
authors.lastname: Corrales
authors.forename: Glòria
authors.initials: G
authors.lastname: Garrabou
authors.forename: Sandra
authors.initials: S
authors.lastname: Hernández
authors.forename: Mireia
authors.initials: M
authors.lastname: Nicolás
authors.forename: Ester
authors.initials: E
authors.lastname: Tobías
authors.forename: Francesc
authors.initials: F
authors.lastname: Cardellach
authors.forename: Oscar
authors.initials: O
authors.lastname: Miró
authors.forename: Clàudia
authors.initials: C
authors.lastname: Fortuny
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001823:Body Composition / Q000187:drug effects; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D004272:DNA, Mitochondrial / Q000032:analysis / Q000378:metabolism; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology / Q000821:virology; D039682:HIV-Associated Lipodystrophy Syndrome / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology / Q000821:virology; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D024101:Mitochondrial Proteins / Q000032:analysis / Q000378:metabolism*; D013030:Spain; D019562:Viral Load / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins