title: Size-selective incorporation of DNA nanocages into nanoporous antimony-doped tin oxide materials.
abstract: A conductive nanoporous antimony-doped tin oxide (ATO) powder has been prepared using the sol-gel method that contains three-dimensionally interconnected pores within the metal oxide and highly tunable pore sizes on the nanoscale. It is demonstrated that these porous materials possess the capability of hosting a tetrahedral-shaped DNA nanostructure of defined dimensions with high affinity. The tunability of pore size enables the porous substrate to selectively absorb the DNA nanostructures into the metal oxide cavities or exclude them from entering the surface layer. Both confocal fluorescence microscopy and solution FRET experiments revealed that the DNA nanostructures maintained their integrity upon the size-selective incorporation into the cavities of the porous materials. As DNA nanostructures can serve as a stable three-dimensional nanoscaffold for the coordination of electron transfer mediators, this work opens up new possibilities of incorporating functionalized DNA architectures as guest molecules to nanoporous conductive metal oxides for applications such as photovoltaics, sensors, and solar fuel cells.
authors.affiliation: The Biodesign Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, USA.
authors.forename: Chad R
authors.initials: CR
authors.lastname: Simmons
authors.forename: Dominik
authors.initials: D
authors.lastname: Schmitt
authors.forename: Xixi
authors.initials: X
authors.lastname: Wei
authors.forename: Dongran
authors.initials: D
authors.lastname: Han
authors.forename: Alex M
authors.initials: AM
authors.lastname: Volosin
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Ladd
authors.forename: Dong-Kyun
authors.initials: DK
authors.lastname: Seo
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
mesh_terms: D000965:Antimony / Q000737:chemistry*; D002232:Carbocyanines / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004553:Electric Conductivity; D008958:Models, Molecular; D058608:Nanopores; D009690:Nucleic Acid Conformation; D017971:Tin Compounds / Q000737:chemistry*
chemical_list: D002232:Carbocyanines; D017971:Tin Compounds; C089187:cyanine dye 3; C085321:cyanine dye 5; D004247:DNA; D000965:Antimony; C045358:stannic oxide