title: Mycophenolate mofetil therapy for juvenile dermatomyositis with immune thrombocytopenic purpura.
abstract: A 6-year-old girl, who had received corticosteroid and cyclosporine on the diagnosis of interstitial pneumonitis related to juvenile dermatomyositis, developed severe thrombocytopenia. Her thrombocytopenia was resistant to repeated intravenous immunoglobulin administration and methylprednisolone pulse therapy. After additional treatment with mycophenolate mofetil (MMF), instead of cyclosporine, the thrombocytopenia improved, facilitating a reduction in the dose of corticosteroid without exacerbation of the interstitial pneumonitis. We propose MMF as effective option in the treatment of immune thrombocytopenic purpura with autoimmune disease.
authors.affiliation: Division of Infectious Disease, Immunology, and Allergy, Saitama Children's Medical Center, Saitama, Japan. chikara.ohgimi.510311@gmail.com
authors.forename: Chikara
authors.initials: C
authors.lastname: Ogimi
authors.forename: Nazuna
authors.initials: N
authors.lastname: Honma
authors.forename: Risa
authors.initials: R
authors.lastname: Tanaka
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Oh-ishi
mesh_terms: D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use; D003882:Dermatomyositis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D020551:Pulse Therapy, Drug; D011696:Purpura, Thrombocytopenic / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D017211:Treatment Failure
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid; D008775:Methylprednisolone