title: Immune responses in the skin in old age.
abstract: A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.
authors.affiliation: Division of Infection and Immunity, Department of Immunology, University College London, London W1T 4JF, United Kingdom.
authors.forename: Milica
authors.initials: M
authors.lastname: Vukmanovic-Stejic
authors.forename: Malcolm H A
authors.initials: MH
authors.lastname: Rustin
authors.forename: Janko
authors.initials: J
authors.lastname: Nikolich-Zugich
authors.forename: Arne N
authors.initials: AN
authors.lastname: Akbar
mesh_terms: D056704:Adaptive Immunity; D000368:Aged; D000375:Aging / Q000276:immunology* / Q000473:pathology; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D004198:Disease Susceptibility; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000473:pathology; D007113:Immunity, Innate; D051379:Mice; D015166:Monitoring, Immunologic; D012867:Skin / Q000276:immunology*; D012874:Skin Diseases, Infectious / Q000209:etiology / Q000276:immunology; D012878:Skin Neoplasms / Q000209:etiology / Q000276:immunology; D037182:T-Cell Antigen Receptor Specificity; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D051193:Toll-Like Receptors / Q000502:physiology
chemical_list: D000941:Antigens; D016207:Cytokines; D051193:Toll-Like Receptors