title: Synthesis, spectral characterization, solution equilibria, in vitro antibacterial and cytotoxic activities of Cu(II), Ni(II), Mn(II), Co(II) and Zn(II) complexes with Schiff base derived from 5-bromosalicylaldehyde and 2-aminomethylthiophene.
abstract: Schiff base namely 2-aminomethylthiophenyl-4-bromosalicylaldehyde (ATS)(4-bromo-2-(thiophen-2-yl-imino)methylphenol) and its metal complexes have been synthesized and characterized by elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment, molar conductance, mass spectra, ESR and thermal analysis (TGA). The analytical data of the complexes show the formation of 1:2 [M:L] ratio of the formula [ML2], where M represents Ni(II), Zn(II) and Cu(II) ions, while L represents the deprotonated Schiff base. IR spectra show that ATS is coordinated to the metal ions in a bidentate manner through azomethine-N and phenolic-oxygen groups. The ligand and their metal chelates have been screened for their antimicrobial activities using the disc diffusion method against the selected bacteria. A cytotoxicity of the compounds against colon (HCT116) and larynx (HEP2) cancer cells have been studied. Protonation constants of (ATS) ligand and stability constants of its Cu2+, Co2+, Mn2+, Zn2+ and Ni2+ complexes were determined by potentiometric titration method in 50% (v/v) DMSO-water solution at ionic strength of 0.1 M NaNO3.
authors.affiliation: Faculty of Science, Chemistry Department, Cairo University, Giza, Egypt. aelsherif72@yahoo.com
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: El-Sherif
authors.forename: Taha M A
authors.initials: TM
authors.lastname: Eldebss
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy; D003300:Copper / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D008345:Manganese / Q000737:chemistry; D013058:Mass Spectrometry; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D013876:Thiophenes / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D015032:Zinc / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D008670:Metals; D009942:Organometallic Compounds; D012545:Schiff Bases; D013876:Thiophenes; C013243:salicylaldehyde; D008345:Manganese; D003300:Copper; D009532:Nickel; D015032:Zinc