title: Cobalt(II)-catalyzed asymmetric hydrosilylation of simple ketones using dipyridylphosphine ligands in air.
abstract: In the presence of PhSiH(3) as the hydride donor, catalytic amounts of non-racemic dipyridylphosphine and an easy-to-handle cobalt salt Co(OAc)(2)·4H(2)O formed in situ an effective catalyst system for the asymmetric reduction of a diverse range of aryl alkyl ketones with moderate-to-excellent enantioselectivities (up to 96% ee). This approach tolerated the handling of both catalyst and reactants under air without special precautions.
authors.affiliation: College of Material, Chemistry and Chemical Engineering and Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yu
authors.forename: Xi-Chang
authors.initials: XC
authors.lastname: Zhang
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Wu
authors.forename: Ji-Ning
authors.initials: JN
authors.lastname: Zhou
authors.forename: Wenjun
authors.initials: W
authors.lastname: Fang
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
mesh_terms: D000388:Air; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D017646:Organosilicon Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010720:Phosphines / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D008024:Ligands; D017646:Organosilicon Compounds; D010720:Phosphines; D011725:Pyridines; D003035:Cobalt