title: General procedure for the synthesis of dinucleoside polyphosphates.
abstract: Dinucleoside 5',5'-polyphosphates (N(p)(n)N) play important roles in biological processes and have been developed into drugs. However, their synthesis still remains a challenge. Here we report a rapid and general approach to the synthesis of dinucleoside 5',5'-polyphosphates by coupling highly reactive nucleoside 5'-monophosphate-N-methylimidazolium salts donors with nucleoside 5'-mono-, -di-, and -triphosphate acceptors.
authors.affiliation: Department of Chemistry, University of Waterloo, 200 University Ave. West, Waterloo, Ontario, Canada.
authors.forename: Samy
authors.initials: S
authors.lastname: Mohamady
authors.forename: Scott D
authors.initials: SD
authors.lastname: Taylor
mesh_terms: D015226:Dinucleoside Phosphates / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D011122:Polyphosphates / Q000737:chemistry*
chemical_list: D015226:Dinucleoside Phosphates; D009711:Nucleotides; D011122:Polyphosphates