title: Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women.
abstract: BACKGROUND
  B vitamins, including vitamin B(6), are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis.
  
  
  METHODS
  We examined the association of dietary vitamin B(6) intake with overall breast cancer risk and breast cancers stratified by hormone receptor status. This case-control study included 391 breast cancer cases and 782 control subjects enrolled at the Tri-Service General Hospital in Taipei, Taiwan. Energy-adjusted intake of vitamin B(6) was derived from a food frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.
  
  
  RESULTS
  As compared with women in the lowest tertile, the multivariate-adjusted ORs for breast cancer among women in the second and highest tertiles of vitamin B(6) intake were 0.78 (95% CI, 0.64-2.52) and 0.64 (0.26-0.92), respectively. In addition, higher vitamin B(6) intake was associated with a significantly lower risk of developing ER-negative breast tumors.
  
  
  CONCLUSIONS
  Our findings suggest that higher intake of vitamin B(6) is associated with a reduction in breast cancer risk, particularly ER-negative tumors.
authors.affiliation: School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Chou
authors.forename: Chi-Hong
authors.initials: CH
authors.lastname: Chu
authors.forename: Mei-Hsuan
authors.initials: MH
authors.lastname: Wu
authors.forename: Giu-Cheng
authors.initials: GC
authors.lastname: Hsu
authors.forename: Tsan
authors.initials: T
authors.lastname: Yang
authors.forename: Wan-Yun
authors.initials: WY
authors.lastname: Chou
authors.forename: Hsin-Ping
authors.initials: HP
authors.lastname: Huang
authors.forename: Meei-Shyuan
authors.initials: MS
authors.lastname: Lee
authors.forename: Cheng-Ping
authors.initials: CP
authors.lastname: Yu
authors.forename: Jyh-Cherng
authors.initials: JC
authors.lastname: Yu
authors.forename: Chien-An
authors.initials: CA
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control*; D016022:Case-Control Studies; D004034:Diet Surveys; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D011960:Receptors, Estrogen / Q000378:metabolism; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D025101:Vitamin B 6 / Q000008:administration & dosage*; D014803:Vitamin B Complex / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D011960:Receptors, Estrogen; D014803:Vitamin B Complex; D025101:Vitamin B 6