title: Pre-transplant positron emission tomography in patients with relapsed Hodgkin lymphoma.
abstract: This retrospective study evaluated the secondary clinical risk score at relapse, the prognostic significance of pre-transplant positron emission tomography (PET), and complete remission (CR) assessed by computed tomography (CT) after salvage chemotherapy before autologous stem cell transplant (ASCT) in 76 patients with relapsed/refractory Hodgkin lymphoma (HL). Median follow-up after ASCT was 23 months. Overall 11/20 PET-positive and 14/56 PET-negative patients relapsed after ASCT. In univariate analysis, only PET negativity before ASCT was significantly associated with better 2-year progression-free survival (PFS) (72.7 ± 6.3% vs. 36.1 ± 11.6%, p = 0.01) and 2-year overall survival (OS) (90.3 ± 4.1% vs. 61.4 ± 11.6%, p = 0.009). Other factors were not significant. In multivariate analysis, none of the evaluated factors were significant for PFS and OS. However, positive pre-transplant PET identified a population with worse PFS and OS at least in univariate analysis.
authors.affiliation: Department of Clinical Hematology, Charles University Hospital Kralovske Vinohrady, Prague, Czech Republic. heidi.mocikova@seznam.cz
authors.forename: Heidi
authors.initials: H
authors.lastname: Mocikova
authors.forename: Robert
authors.initials: R
authors.lastname: Pytlik
authors.forename: Jana
authors.initials: J
authors.lastname: Markova
authors.forename: Katerina
authors.initials: K
authors.lastname: Steinerova
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Kral
authors.forename: David
authors.initials: D
authors.lastname: Belada
authors.forename: Marie
authors.initials: M
authors.lastname: Trnkova
authors.forename: Marek
authors.initials: M
authors.lastname: Trneny
authors.forename: Vladimir
authors.initials: V
authors.lastname: Koza
authors.forename: Jiri
authors.initials: J
authors.lastname: Mayer
authors.forename: Pavel
authors.initials: P
authors.lastname: Zak
authors.forename: Tomas
authors.initials: T
authors.lastname: Kozak
mesh_terms: D000328:Adult; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D016879:Salvage Therapy; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult