title: Association of lipoprotein-associated phospholipase A(2) and endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA).
abstract: Mechanisms underlying the role of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) in atherosclerotic development are not completely understood. We evaluated the relationship of Lp-PLA(2) with endothelial dysfunction, an early manifestation of atherosclerosis, in a cohort without known clinical cardiovascular disease. A total of 2809 participants in the Multi-Ethnic Study of Atherosclerosis underwent plasma Lp-PLA(2) mass and activity measurement and brachial artery flow-mediated vasodilation testing. In adjusted linear regression models, higher Lp-PLA(2) mass and activity levels were not associated with lower endothelial function (-0.04%, p = 0.51 and -0.09%, p = 0.10, respectively). Among individuals with subclinical atherosclerosis based on ankle-brachial index (ABI) or carotid intima-media thickness (IMT), Lp-PLA(2) mass and activity were not associated with lower endothelial function (-0.03%, p = 0.88 and -0.31%, p = 0.16 for ABI < 1.00; 0.01%, p = 0.94 and -0.15%, p = 0.20 for abnormal carotid IMT). In summary, Lp-PLA(2) is not associated with endothelial dysfunction, suggesting its role in atherosclerosis development is primarily related to other factors.
authors.affiliation: Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. nwu-pkg623@md.northwestern.edu
authors.forename: Parveen K
authors.initials: PK
authors.lastname: Garg
authors.forename: Robyn L
authors.initials: RL
authors.lastname: McClelland
authors.forename: Nancy S
authors.initials: NS
authors.lastname: Jenny
authors.forename: Michael
authors.initials: M
authors.lastname: Criqui
authors.forename: Kiang
authors.initials: K
authors.lastname: Liu
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Polak
authors.forename: Neal W
authors.initials: NW
authors.lastname: Jorgensen
authors.forename: Mary
authors.initials: M
authors.lastname: Cushman
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000175:diagnosis / Q000201:enzymology* / Q000208:ethnology / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D054467:Phospholipases A2 / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011874:Radiometry; D018570:Risk Assessment; D012307:Risk Factors; D014463:Ultrasonography; D014481:United States / Q000453:epidemiology; D014664:Vasodilation
chemical_list: D015415:Biomarkers; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C526684:PLA2G7 protein, human