title: Erythroderma as a paraneoplastic cutaneous disorder in systemic anaplastic large cell lymphoma.
abstract: BACKGROUND
  Paraneoplastic cutaneous disorders (PCDs) or dermadromes are skin conditions that have an association with internal malignancies but are not themselves malignant. We report the first two cases of systemic anaplastic large cell lymphoma (s-ALCL) accompanied by erythroderma and multiple leg ulcers as PCDs. CASE 1:  A 52-year-old Japanese man presented with disseminated itchy papular erythemas which he had over his entire body for the preceding 5 years that later exacerbated to erythroderma. Multiple punched-out ulcers also developed on his lower legs. Superficial lymph nodes (LNs) were swollen, and a left axillary LN biopsy demonstrated dense CD30(+) atypical large cell (ALC) infiltration. By contrast, lymphocytes infiltrating into the erythroderma and leg ulcers were CD30(-) , and T-cell receptor β (TCRβ) chain gene rearrangement was negative in skin biopsy specimens. Thus, he was diagnosed with s-ALCL. Not only his s-ALCL but also his erythroderma and leg ulcers responded well to chemotherapy. CASE 2:  A 71-year-old Japanese woman presented with erythroderma that persisted for approximately 20 years after mastectomy. At her initial hospital visit, she was diagnosed with s-ALCL by biopsy of swollen left inguinal LNs. Similar to Case 1, CD30(+) ALCs were negative in skin samples with normal TCRβ chain gene rearrangement. As the erythrodermic skin lesion responded well to chemotherapy for s-ALCL, it was considered a PCD.
  
  
  CONCLUSIONS
  s-ALCL development may be predicted by the precedence and concurrence of intractable paraneoplastic erythrodermic and ulcerative skin lesions, as reported in our two cases.
authors.affiliation: Department of Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hanafusa
authors.forename: K
authors.initials: K
authors.lastname: Igawa
authors.forename: S
authors.initials: S
authors.lastname: Takagawa
authors.forename: H
authors.initials: H
authors.lastname: Yahara
authors.forename: J
authors.initials: J
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Tani
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
authors.forename: I
authors.initials: I
authors.lastname: Katayama
mesh_terms: D000368:Aged; D003873:Dermatitis, Exfoliative / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D012878:Skin Neoplasms / Q000150:complications* / Q000276:immunology / Q000503:physiopathology