title: A comparative split-face study of photodynamic therapy with indocyanine green and indole-3-acetic acid for the treatment of acne vulgaris.
abstract: BACKGROUND
  Recently, photodynamic therapy (PDT) using a variety of light sources and photosensitizers has been used for the treatment of acne vulgaris. PDT with aminolaevulinic or methylaminolaevulinic acid has also been used in clinical trials as a treatment for acne, but adverse effects such as pain, erythema and pustular eruption are common. Indocyanine green (ICG) and indole-3-acetic acid (IAA), newer photosensitizers, are known to have minimal adverse effects.
  
  
  OBJECTIVE
  This study was designed to compare the safety and efficacy of PDT using ICG and PDT using IAA in the treatment of mild to moderate acne vulgaris.
  
  
  METHODS
  In this prospective, single-blind, clinical trial, 34 patients with mild to moderate acne were treated with IAA with green light (520 nm) on half of the face and with ICG with near-infrared radiation (805 nm) on the other half. The procedure was carried out five times at 1-week intervals.
  
  
  RESULTS
  With regard to acne lesions (inflammatory and noninflammatory) and sebum secretion, there were statistically significant reductions at each time point compared with the baseline values (P < 0·05). However, there were no statistically significant differences between the two treatment types (P > 0·05). Both ICG-PDT and IAA-PDT showed better responses for inflammatory lesions than for noninflammatory lesions (P < 0·05). Subjective satisfaction score were statistically significant at 4 and 5 weeks of treatment as well as at 1, 2 and 3 months follow-up (P < 0·05).
  
  
  CONCLUSIONS
  Both PDT with ICG and PDT with IAA are safe and effective for the treatment of mild to moderate acne vulgaris.
authors.affiliation: Department of Dermatology, Kosin University College of Medicine, Busan 602-702, Korea.
authors.forename: M S
authors.initials: MS
authors.lastname: Jang
authors.forename: K S
authors.initials: KS
authors.lastname: Doh
authors.forename: J S
authors.initials: JS
authors.lastname: Kang
authors.forename: Y S
authors.initials: YS
authors.lastname: Jeon
authors.forename: K S
authors.initials: KS
authors.lastname: Suh
authors.forename: S T
authors.initials: ST
authors.lastname: Kim
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000378:metabolism; D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage* / Q000009:adverse effects; D007210:Indoleacetic Acids / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D009824:Ointments; D017060:Patient Satisfaction; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000009:adverse effects; D012629:Sebum / Q000378:metabolism; D016037:Single-Blind Method; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D007210:Indoleacetic Acids; D009824:Ointments; D017319:Photosensitizing Agents; C030737:indoleacetic acid; D007208:Indocyanine Green