title: Autoimmune alternating hypo- and hyperthyroidism in children.
abstract: Two children presented with autoimmune alternating hypo- and hyperthyroidism related to the presence of blocking and stimulating thyroid antibodies. It was difficult to control their thyroid function adequately with an appropriate single drug regimen, and both children underwent total thyroidectomy with subsequent stable management with levothyroxine replacement therapy postsurgically. Although this phenomenon is well described in adults, this report is the first of such occurrence in children. The possible mechanism for the variation in the type of clinical presentation and options for management are discussed.
authors.affiliation: Monore Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN 37232-9170, USA.
authors.forename: Revi P
authors.initials: RP
authors.lastname: Mathew
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Moore
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy / Q000276:immunology* / Q000601:surgery; D007037:Hypothyroidism / Q000188:drug therapy / Q000276:immunology* / Q000601:surgery; D013963:Thyroid Hormones / Q000627:therapeutic use*; D013965:Thyroidectomy; D013974:Thyroxine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013963:Thyroid Hormones; D013974:Thyroxine