title: Anti genotoxic effect of Mosinone-A on 7, 12-dimethyl benz[a] anthracene induced genotoxicity in male golden Syrian hamsters.
abstract: The present study was aimed to evaluate the antigenotoxic effect of Mosinone-A on 7,12-dimethylbenz[a]anthracene induced genotoxicity. The frequency of micronucleated polychromatic erythrocytes [MnPCEs], chromosomal aberrations [CA], DNA damage (comet assay) as cytogenetic markers and the status of lipid peroxidation byproducts, antioxidants and phase II detoxification agents were used as biochemical markers to assess the antigenotoxic effect of Mosinone-A on DMBA induced genotoxicity. A single intraperitoneal injection of DMBA (30 mg/kg b.wt) to golden Syrian hamsters, resulted in marked elevation in the frequency of MnPCEs, aberrations in the chromosomal structure were found in bone marrow and DNA damage (comet assay) was found in blood cells and altered level of lipid peroxidation, antioxidants, and phase II detoxification agents. Oral pretreatment of Mosinone-A (2 mg/kg b.wt) for 5 days to DMBA treated animals significantly reduced the frequency of MnPCEs, chromosomal abnormalities such as chromosomal break, gap, minute, fragment, DNA damage and reversed the status of biochemical variables. Our results thus demonstrated the antigenotoxic effect of Mosinone-A on DMBA induced genotoxicity in male golden Syrian hamsters.
authors.affiliation: Department of Biochemistry & Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Sugunadevi
authors.forename: Kathiresan
authors.initials: K
authors.lastname: Suresh
authors.forename: Mariadoss Arokia
authors.initials: MA
authors.lastname: Vijayaanand
authors.forename: Kasinathan
authors.initials: K
authors.lastname: Rajalingam
authors.forename: Jagadeesan
authors.initials: J
authors.lastname: Sathiyapriya
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001854:Bone Marrow Cells; D002273:Carcinogens; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000187:drug effects*; D020552:Comet Assay; D006224:Cricetinae; D004912:Erythrocytes / Q000187:drug effects; D005663:Furans / Q000494:pharmacology*; D007783:Lactones / Q000494:pharmacology*; D008099:Liver / Q000737:chemistry; D008297:Male; D008647:Mesocricetus; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced / Q000187:drug effects; D015162:Micronucleus Tests; D020011:Protective Agents / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D002273:Carcinogens; D005663:Furans; D007783:Lactones; D020011:Protective Agents; D017392:Thiobarbituric Acid Reactive Substances; C107771:mosinone A; D015127:9,10-Dimethyl-1,2-benzanthracene