title: Detecting misery perfusion in unilateral steno-occlusive disease of the internal carotid artery or middle cerebral artery by MR imaging.
abstract: OBJECTIVE
  Elevated OEF is a surrogate for misery perfusion. Our aim was to detect misery perfusion in patients with unilateral steno-occlusive disease of the ICA or MCA by using T2*-based MR imaging and to determine the relationship between brain ischemia and OEF.
  
  
  METHODS
  Twenty-three patients with unilateral steno-occlusive disease of the ICA or MCA and 8 healthy volunteers were included in this study. Hemodynamic information was obtained in all subjects by MR imaging. Three regions of interest were placed in the anterior, middle, and posterior parts of the brain bilaterally to measure the OEF and CBF values. The OEFs of the regions of interest in the hemispheres ipsilateral and contralateral to the vascular lesions were compared. Brain regions with OEF greater than that in controls were determined as misery perfusion in patients. The association of vascular lesions, rCBF, and the presence of territory infarction with elevated OEF was investigated.
  
  
  RESULTS
  There was a statistically significant difference in OEF between the ipsilateral and contralateral hemispheres in the patients (t = 3.632, P = .001). Fourteen regions of interest with misery perfusion were determined in the ipsilateral hemispheres, while 3 regions with elevated OEFs were found in the contralateral hemispheres. In the ipsilateral hemispheres, decreased rCBF was associated with elevated OEF (r = -0.451, P < .001). Patients with territory infarction had more regions of interest with misery perfusion than patients without territory infarction (χ(2) = 3.889, P = .049).
  
  
  CONCLUSIONS
  By using the MR imaging technique, misery perfusion demonstrated as elevated OEF was detected in patients with severe atherosclerotic ICA or MCA disease. Identification of misery perfusion with MR imaging may be helpful in the evaluation of brain ischemia.
authors.affiliation: Department of Radiology, Peking University First Hospital, Beijing, China.
authors.forename: S
authors.initials: S
authors.lastname: Xie
authors.forename: L H
authors.initials: LH
authors.lastname: Hui
authors.forename: J X
authors.initials: JX
authors.lastname: Xiao
authors.forename: X D
authors.initials: XD
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Peng
mesh_terms: D001157:Arterial Occlusive Diseases / Q000175:diagnosis* / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen