title: Prevention of postoperative seroma-related morbidity by quilting of latissimus dorsi flap donor site: a systematic review.
abstract: OBJECTIVE
  To systematically analyze the effectiveness of quilting of latissimus dorsi (LD) flap donor site in the prevention of seroma and related morbidities.
  
  
  METHODS
  All published studies comparing the effectiveness of quilting versus no-quilting of LD flap donor site in the prevention of seroma and related morbidities in patients undergoing breast reconstruction were analysed systemically.
  
  
  RESULTS
  Five comparative studies on quilting versus no-quilting encompassing 440 patients were suitable for statistical analysis. There was no heterogeneity among trials. Therefore, in the fixed-effects model, quilting was effective in terms of reducing the incidence of donor-site seroma formation, reducing the average volume of the seroma, and reducing the total volume of drained seroma. In addition, quilting did not increase the risk of postoperative complications. Combined quilting and fibrin glue was also effective in reducing the average volume of the seroma and total drained volume of the seroma. Combination of quilting and glue did not influence the incidence of seroma formation at LD flap donor site and overall operative complications.
  
  
  CONCLUSIONS
  Quilting of the LD flap donor site is helpful in reducing the incidence of seroma formation, reducing seroma volume, and reducing total drained seroma volume. Combined quilting and fibrin glue further enhances its effectiveness. Quilting with or without fibrin glue may be considered an option in patients undergoing LD flap breast reconstruction to control seroma-related morbidity. However, a major multicenter randomized controlled trial is required to achieve stronger and reliable evidence before recommending it as a routine procedure.
authors.affiliation: Department of Breast and Oncoplastic Surgery, Worthing Hospital, Worthing, West Sussex, UK. surgeon1wrh@hotmail.com
authors.forename: M S
authors.initials: MS
authors.lastname: Sajid
authors.forename: D
authors.initials: D
authors.lastname: Betal
authors.forename: N
authors.initials: N
authors.lastname: Akhter
authors.forename: I F
authors.initials: IF
authors.lastname: Rapisarda
authors.forename: R
authors.initials: R
authors.lastname: Bonomi
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D049291:Seroma / Q000517:prevention & control*; D013524:Surgical Flaps; D013536:Suture Techniques; D016896:Treatment Outcome