title: Catalytic asymmetric addition of thiols to nitrosoalkenes leading to chiral non-racemic α-sulfenyl ketones.
abstract: The first asymmetric organocatalytic sulfenylation of in situ derived nitrosoalkenes leading to chiral nonracemic α-sulfenylated ketones is described. The transformation proceeds in an umpolung fashion, relative to enolate/azaenolate methods, and uses simple thiols, thereby obviating the need for electrophilic sulfur reagents.
authors.affiliation: Department of Chemistry, Duke University, Durham, North Carolina 27708, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Hatcher
authors.forename: Mark C
authors.initials: MC
authors.lastname: Kohler
authors.forename: Don M
authors.initials: DM
authors.lastname: Coltart