title: [Prophylaxis of ischemic heart lesions during chronic heart failure with complex therapy using Q10 coenzyme].
abstract: Dysfunction of energy processes in the myocardium, resulting the background of ischemic syndrome, and inadequate intake of energy substrates process and/or breach of energetic cofactors of oxidation are an important pathogenetic aspects of the progression of myocardial dysfunction and congestive heart failure. Level of Q10 Coenzyme plays a key role in the functioning of the respiratory mitochondrial chains, exerting a significant influence on the synthesis of ATP. The article provides data on the use of Q10 coenzyme in the treatment of 76 patients with circulatory failure. The data obtained points on the improvement of myocardial contractility, increased exercise tolerance, reduced content of the final products of lipid peroxidation in plasma, a positive effect on blood lipid profile with the addition of Qudesan to standard therapy of heart failure.
authors.forename: A M
authors.initials: AM
authors.lastname: Shilov
authors.forename: M V
authors.initials: MV
authors.lastname: Mel'nik
authors.forename: E S
authors.initials: ES
authors.lastname: Voevodina
authors.forename: A O
authors.initials: AO
authors.lastname: Osiia
authors.forename: D A
authors.initials: DA
authors.lastname: Griaznov
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004734:Energy Metabolism / Q000187:drug effects; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D014451:Ubiquinone; C024989:coenzyme Q10