title: Impact of personal and ambient-level exposures to nitrogen dioxide and particulate matter on cardiovascular function.
abstract: This work explored the association between nitrogen dioxide (NO(2)) and PM(2.5) components with changes in cardiovascular function in an adult non-smoking cohort. The cohort consisted of 65 volunteers participating in the US EPA's Detroit Exposure and Aerosol Research Study (DEARS) and a University of Michigan cardiovascular sub-study. Systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), brachial artery diameter (BAD), brachial artery flow-mediated dilatation (FMD) and nitroglycerin-mediated arterial dilatation (NMD) were collected by in-home examinations. A maximum of 336 daily environmental and health effect observations were obtained. Daily potassium air concentrations were associated with significant decreases in DBP (-0.0447 mmHg/ng/m(3) ± 0.0132, p = 0.0016, lag day 0) among participants compliant with the personal monitoring protocol. Personal NO(2) exposures resulted in significant changes in BAD (e.g., 0.0041 mm/ppb ± 0.0019, p = 0.0353, lag day 1) and FMD (0.0612 ± 0.0235, p = 0.0103, lag day 0) among other findings.
authors.affiliation: National Exposure Research Laboratory, U.S. Environmental Protection Agency (US EPA), Research Triangle Park, NC, USA. williams.ronald@epa.gov
authors.forename: Ron
authors.initials: R
authors.lastname: Williams
authors.forename: Robert
authors.initials: R
authors.lastname: Brook
authors.forename: Robert
authors.initials: R
authors.lastname: Bard
authors.forename: Teri
authors.initials: T
authors.lastname: Conner
authors.forename: Hwashin
authors.initials: H
authors.lastname: Shin
authors.forename: Richard
authors.initials: R
authors.lastname: Burnett
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D001916:Brachial Artery / Q000473:pathology; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015331:Cohort Studies; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000032:analysis / Q000633:toxicity*; D052638:Particulate Matter / Q000032:analysis / Q000633:toxicity*; D011188:Potassium / Q000032:analysis; D018709:Statistics, Nonparametric
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D011188:Potassium; D009585:Nitrogen Dioxide