title: The association among lipoprotein-associated phospholipase A2 levels, total antioxidant capacity and arousal in male patients with OSA.
abstract: BACKGROUND
  The mechanisms of the increased cardiac and vascular events in patients with OSA are not well understood. Arousal which is an important component of OSA was associated with increased sympathetic activation and electrocardiographic changes which prone to arrhythmias. We planned to examine the association among arousal, circulating Lp-PLA2 and total antioxidant capacity in male patients with OSA.
  
  
  METHODS
  Fifty male patients with newly diagnosed OSA were enrolled the study. A full-night polysomnography was performed and arousal index was obtained. Lp-PLA2 concentrations were measured in serum samples with the PLAC Test. Total antioxidant capacity in patients was determined with Antioxidant Assay Kit.
  
  
  RESULTS
  Arousal was positively correlated with LP-PLA2 levels (r=0.43, p=0.002) and was negatively correlated with total antioxidant capacity (r= -0.29, p=0.04). Elevated LP-PLA2 levels and decreased total antioxidant activities were found in the highest arousal quartile compared with the lowest and 2nd quartiles (p=0.02, p=0.05, respectively). LP-PLA2 was an independently predictor of arousal index in regression model (β=0.357, p=0.002)
  
  
  CONCLUSIONS
  This study demonstrated a moderate linear relationship between arousal and LP-PLA2 levels. Also, total antioxidant capacities were decreased in the higher arousal index. Based on the study result, the patients with higher arousal index may be prone to vascular events.
authors.affiliation: Department of Pulmonary Medicine, Konya Education and Research Hospital, Konya/ Turkey. tahabekci@yahoo.com
authors.forename: Taha T
authors.initials: TT
authors.lastname: Bekci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kayrak
authors.forename: Aysel
authors.initials: A
authors.lastname: Kiyici
authors.forename: Emin
authors.initials: E
authors.lastname: Maden
authors.forename: Hatem
authors.initials: H
authors.lastname: Ari
authors.forename: Zeynettin
authors.initials: Z
authors.lastname: Kaya
authors.forename: Turgut
authors.initials: T
authors.lastname: Teke
authors.forename: Hakan
authors.initials: H
authors.lastname: Akilli
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001143:Arousal; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D054467:Phospholipases A2 / Q000097:blood*; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000201:enzymology
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D054467:Phospholipases A2