title: Synthesis and cytotoxic evaluation of novel N-methyl-4-phenoxypicolinamide derivatives.
abstract: A series of N-methyl-4-phenoxypicolinamide derivatives were synthesized and evaluated in vitro for their cytotoxic activity against A549, H460 and HT29 cell lines. Pharmacological data indicated that some of the target compounds possessed marked antiproliferative activity, superior to that of the reference drug sorafenib. As the most promising compound, 8e exhibited potent cytotoxicity with the IC(50) value of 3.6, 1.7 and 3.0 μM against A549, H460 and HT-29 cell lines, respectively.
authors.affiliation: Key Laboratary of Original New Drugs Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Zhai
authors.forename: Lu
authors.initials: L
authors.lastname: Ding
authors.forename: Limin
authors.initials: L
authors.lastname: Sun
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Gong
authors.forename: Tiemin
authors.initials: T
authors.lastname: Sun
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019073:HT29 Cells; D006801:Humans; D010848:Picolinic Acids / Q000138:chemical synthesis* / Q000633:toxicity*
chemical_list: D000577:Amides; D010848:Picolinic Acids; C003142:picolinamide