title: Profile of serum bile acids in noncholestatic volunteers: gender-related differences in response to fenofibrate.
abstract: Fenofibrate belongs to the group of hypolipidemic fibrates that act as activators of the peroxisome proliferator-activated receptor-α (PPARα), which is a regulator of bile acid synthesis, metabolism, and transport. The present study aimed at evaluating the effects of fenofibrate on the circulating bile acid profile in humans. A study population of 200 healthy individuals comprising both genders completed a 3-week intervention with fenofibrate, and 17 bile acid species were measured in serum samples drawn before and after fenofibrate treatment. Fenofibrate caused significant reductions in levels of chenodeoxycholic (CDCA) (-26.4%), ursodeoxycholic (UDCA) (-30.5%), lithocholic (LCA) (-18.4%), deoxycholic (DCA) (-22.3%), and hyodeoxycholic (HDCA) (-19.2%) acids. A gender-related difference was observed in the responses of various bile acids, and the total bile acid concentration was significantly reduced only in men (-18.6%), whereas it remained almost unchanged in women (+0.36%). This difference suggests that fenofibrate would be more efficient at reducing bile acid toxicity in men than in women in cholestatic liver diseases.
authors.affiliation: Laboratory of Molecular Pharmacology, Molecular Endocrinology and Oncology Research Center, CHUQ Research Center, Quebec, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Trottier
authors.forename: P
authors.initials: P
authors.lastname: Caron
authors.forename: R J
authors.initials: RJ
authors.lastname: Straka
authors.forename: O
authors.initials: O
authors.lastname: Barbier
mesh_terms: D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000097:blood* / Q000378:metabolism; D005260:Female; D011345:Fenofibrate / Q000494:pharmacology*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D047493:PPAR alpha / Q000187:drug effects / Q000378:metabolism; D012737:Sex Factors
chemical_list: D001647:Bile Acids and Salts; D000960:Hypolipidemic Agents; D047493:PPAR alpha; D011345:Fenofibrate