title: Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009.
abstract: BACKGROUND
  The present study assessed the temporal trend in serum concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls (PCBs) among residents of a Russian town where levels of these chemicals are elevated due to prior industrial activity.
  
  
  METHODS
  Two serum samples were collected from eight adult women (in 2000 and 2009), and analyzed with gas chromatography-high-resolution mass spectrometry.
  
  
  RESULTS
  The average total toxic equivalency (TEQ) decreased by 30% (from 36 to 25 pg/g lipid), and the average sum of PCB congeners decreased by 19% (from 291 to 211 ng/g lipid). Total TEQs decreased for seven of the eight women, and the sum of PCBs decreased for six of eight women. During this nine year period, larger decreases in serum TEQs and PCBs were found in women with greater increases in body mass index.
  
  
  CONCLUSIONS
  This study provides suggestive evidence that average serum concentrations of dioxins, furans, and PCBs are decreasing over time among residents of this town.
authors.affiliation: Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: Olivier
authors.initials: O
authors.lastname: Humblet
authors.forename: Oleg
authors.initials: O
authors.lastname: Sergeyev
authors.forename: Larisa
authors.initials: L
authors.lastname: Altshul
authors.forename: Susan A
authors.initials: SA
authors.lastname: Korrick
authors.forename: Paige L
authors.initials: PL
authors.lastname: Williams
authors.forename: Claude
authors.initials: C
authors.lastname: Emond
authors.forename: Linda S
authors.initials: LS
authors.lastname: Birnbaum
authors.forename: Jane S
authors.initials: JS
authors.lastname: Burns
authors.forename: Mary M
authors.initials: MM
authors.lastname: Lee
authors.forename: Boris
authors.initials: B
authors.lastname: Revich
authors.forename: Andrey
authors.initials: A
authors.lastname: Shelepchikov
authors.forename: Denis
authors.initials: D
authors.lastname: Feshin
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000097:blood*; D004147:Dioxins / Q000097:blood*; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008137:Longitudinal Studies; D011078:Polychlorinated Biphenyls / Q000097:blood*; D012426:Russia; D055815:Young Adult
chemical_list: D001572:Benzofurans; D004147:Dioxins; D004785:Environmental Pollutants; C023614:dibenzofuran; D011078:Polychlorinated Biphenyls