title: Material properties in complement activation.
abstract: Uncontrolled complement activation can induce many inflammatory and life threatening conditions. Accordingly, the role of complement in initiation of adverse reactions to polymers and nanoparticulate drug carriers is receiving increasing attention and has prompted extensive 'structure-immune performance' relationship studies in nanomedicine research at many fronts. The interaction between nanomaterials and the complement system is complex and regulated by inter-related factors that include nanoscale size, morphology and surface characteristics. Each of these parameters may affect complement activation differently and through different sensing molecules and initiation pathways. The importance of material properties in triggering complement is considered and mechanistic aspects discussed. Mechanistic understanding of complement events could provide rational approaches for improved material design and nanoengineering strategies for clinical medicine.
authors.affiliation: Centre for Pharmaceutical Nanotechnology and Nanotoxicology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark. momo@farma.ku.dk
authors.forename: S Moein
authors.initials: SM
authors.lastname: Moghimi
authors.forename: Alina J
authors.initials: AJ
authors.lastname: Andersen
authors.forename: Davoud
authors.initials: D
authors.lastname: Ahmadvand
authors.forename: Peter P
authors.initials: PP
authors.lastname: Wibroe
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Andresen
authors.forename: A Christy
authors.initials: AC
authors.lastname: Hunter
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D003167:Complement Activation / Q000187:drug effects* / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology*; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D011108:Polymers / Q000494:pharmacology*
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D003165:Complement System Proteins