title: Does fat fuel the fire: independent and interactive effects of genetic, physiological, and environmental factors on variations in fat deposition and distribution across populations.
abstract: Markers of inflammation (MOI) have been reported to influence bone health in adults, with reports of inverse associations. Adipose has also been linked to bone. In children, the interrelationships are unclear. The objective of this study was to evaluate the relationship between MOI (i.e. CRP, TNFR2, IL-6) and bone mineral content (BMC) and determine the contribution of fat deposition/distribution in children. Forty-nine children (59% male) 7-12 y participated. Body composition was evaluated by DXA, and MOI and insulin sensitivity (S(I)) were obtained during an IVGTT. Multiple linear regression was used for analyses. TNFR2 was inversely associated with BMC. In boys, TNFR2 was inversely associated with BMC, and in girls IL-6 was inversely associated with BMC, and total and percent fat influenced the relationships. Our results suggest a potential inhibitory role of inflammation on bone as well as a negative impact of adiposity. Future investigations are warranted to further investigate these relationships.
authors.affiliation: Department of Nutrition Sciences, University ofAlabama at Birmingham, Birmingham, AL, USA. hankslj@uab.edu
authors.forename: Lynae J
authors.initials: LJ
authors.lastname: Hanks
authors.forename: Krista
authors.initials: K
authors.lastname: Casazza
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Alvarez
authors.forename: Jose R
authors.initials: JR
authors.lastname: Fernandez
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity; D001823:Body Composition; D015519:Bone Density; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D004777:Environment; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D012727:Sex Characteristics
chemical_list: D015850:Interleukin-6; D047889:Receptors, Tumor Necrosis Factor, Type II; D002097:C-Reactive Protein