title: Total synthesis of isofregenedadiol.
abstract: The first total synthesis of isofregenedadiol, a bicyclic diterpene isolated from H. Viscosum, is reported starting from a D-(-)-pantolactone chiral pool. A one-pot quadruple reaction sequence comprising an enyne ring-closing metathesis/cross-metathesis/Diels-Alder/aromatization for the construction of a target skeleton is the highlight of the present synthesis.
authors.affiliation: Discovery Chemistry, Advinus Therapeutics Ltd., Quantum Towers, Plot No. 9, Rajiv Gandhi Infotech Park, Phase-I, Hinjewadi, Pune, 411057, India.
authors.forename: Suresh E
authors.initials: SE
authors.lastname: Kurhade
authors.forename: Abbas I
authors.initials: AI
authors.lastname: Sanchawala
authors.forename: Velayutham
authors.initials: V
authors.lastname: Ravikumar
authors.forename: Debnath
authors.initials: D
authors.lastname: Bhuniya
authors.forename: D Srinivasa
authors.initials: DS
authors.lastname: Reddy
mesh_terms: D030601:Cistaceae / Q000737:chemistry; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; C561697:isofregenedadiol