title: Feasibility of tomotherapy for Graves' ophthalmopathy: Dosimetry comparison with conventional radiotherapy.
abstract: OBJECTIVE
  To compare the dosimetry of tomotherapy and the conventional half-beam technique (HBT) or non-split beam technique (NSBT) for target coverage and radiation dose to the lacrimal glands and lens.
  
  
  METHODS
  A retrospective review of 7 patients with Graves' ophthalmopathy who had radiotherapy because of disease progression on high steroid dose is reported: 3 patients were treated with tomotherapy and 4 patients with HBT.
  
  
  RESULTS
  Compared to HBT, tomotherapy may provide better target coverage and significant reduction of radiation dose to the lacrimal glands and a higher dose to the lens. The NSBT improved target coverage but resulted in significantly higher doses to the lens and lacrimal glands.
  
  
  CONCLUSIONS
  Tomotherapy may provide better coverage of the target volume and may be more effective in reducing severe exophthalmos compared to the conventional radiotherapy technique.
authors.affiliation: Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA. NamPhong.Nguyen@yahoo.com
authors.forename: Nam P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: Shane P
authors.initials: SP
authors.lastname: Krafft
authors.forename: Paul
authors.initials: P
authors.lastname: Vos
authors.forename: Vincent
authors.initials: V
authors.lastname: Vinh-Hung
authors.forename: Misty
authors.initials: M
authors.lastname: Ceizyk
authors.forename: Siyoung
authors.initials: S
authors.lastname: Jang
authors.forename: Anand
authors.initials: A
authors.lastname: Desai
authors.forename: Dave
authors.initials: D
authors.lastname: Abraham
authors.forename: Lars
authors.initials: L
authors.lastname: Ewell
authors.forename: Christopher
authors.initials: C
authors.lastname: Watchman
authors.forename: Russ
authors.initials: R
authors.lastname: Hamilton
authors.forename: Beng-Hoey
authors.initials: BH
authors.lastname: Jo
authors.forename: Ulf
authors.initials: U
authors.lastname: Karlsson
authors.forename: Lexie
authors.initials: L
authors.lastname: Smith-Raymond
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D004351:Drug Resistance; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D049970:Graves Ophthalmopathy / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated / Q000295:instrumentation*; D012189:Retrospective Studies; D036542:Tomography, Spiral Computed / Q000295:instrumentation*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone