title: Rapid rehydration and moderate plasma glucose elevation by fluid containing enzymatically synthesized glycogen.
abstract: Enzymatically synthesized glycogen (ESG) has high solubility and its solution has low osmotic pressure. Therefore ESG solution could be rapidly absorbed and could be adequate for water rehydration and carbohydrate supplementation during exercise. The object of this study was to evaluate the gastric emptying time and plasma glucose elevation after an administration of ESG solution in comparison with another carbohydrate solution by using a laboratory animal. Male BALB/c mice were administered 10% w/v solution of glucose, maltodextrin, starch, naturally synthesized glycogen (NSG) and ESG at a dose of 20 µL/g body weight for the measurement of gastric emptying rate (Experiment 1) and 10 µL/g body weight for the measurement of plasma glucose elevation (Experiment 2). The osmolarity of gastric content was lower in the ESG and maltodextrin group than the other carbohydrate group. Weight of gastric fluid was significantly lower in the ESG and water group than the glucose group (p<0.01). Plasma glucose level was significantly lower in the ESG group than the glucose group from 0 to 60 min after administration (p<0.01), whereas plasma glucose level was same from 60 to 120 min for the ESG and glucose group (p=0.948). In Experiment 3, BALB/c mice ran on a treadmill for 2 h and were administered 8% of ESG or glucose solution (1.75, 3.5 or 7.0 µL/g body weight) every 20 min during running. There was no difference in post-exercise muscle glycogen level. These data suggest that 1) ESG beverage does not disturb water absorption because of its short gastric emptying time and 2) ESG slowly elevates plasma glucose level and maintains it for a prolonged time compared to the glucose solution.
authors.affiliation: Department of Human Nutrition, School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Inagaki
authors.forename: Kengo
authors.initials: K
authors.lastname: Ishihara
authors.forename: Mariko
authors.initials: M
authors.lastname: Ishida
authors.forename: Ai
authors.initials: A
authors.lastname: Watanabe
authors.forename: Mika
authors.initials: M
authors.lastname: Fujiwara
authors.forename: Yuko
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Mika
authors.initials: M
authors.lastname: Shirai
authors.forename: Yoshiho
authors.initials: Y
authors.lastname: Kato
authors.forename: Ami
authors.initials: A
authors.lastname: Takanezawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Furuyashiki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takata
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Seyama
mesh_terms: D000818:Animals; D001628:Beverages; D001786:Blood Glucose / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000378:metabolism / Q000494:pharmacology*; D019587:Dietary Supplements; D005440:Fluid Therapy / Q000379:methods*; D005746:Gastric Emptying / Q000187:drug effects; D005750:Gastric Juice / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism / Q000494:pharmacology*; D007408:Intestinal Absorption; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018482:Muscle, Skeletal / Q000378:metabolism; D009994:Osmolar Concentration; D010805:Physical Conditioning, Animal / Q000502:physiology; D011134:Polysaccharides / Q000494:pharmacology; D012420:Running / Q000502:physiology*; D013270:Stomach / Q000187:drug effects*; D014867:Water / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D011134:Polysaccharides; D014867:Water; C008315:maltodextrin; D006003:Glycogen; D005947:Glucose