title: A Teflon microreactor with integrated piezoelectric actuator to handle solid forming reactions.
abstract: We present a general inexpensive method for realizing a Teflon stack microreactor with an integrated piezoelectric actuator for conducting chemical synthesis with solid products. The microreactors are demonstrated with palladium-catalyzed C-N cross-coupling reactions, which are prone to clogging microchannels by forming insoluble salts as by-products. Investigations of the ultrasonic waveform applied by the piezoelectric actuator reveal an optimal value of 50 kHz at a load power of 30 W. Operating the system at these conditions, the newly developed Teflon microreactor handles the insoluble solids formed and no clogging is observed. The investigated reactions reach full conversion in very short reaction times and high isolated yields are obtained (>95% yield).
authors.affiliation: Department of Chemical Engineering, MIT, 77 Massachusetts Avenue, 66-350, Cambridge, MA, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Kuhn
authors.forename: Timothy
authors.initials: T
authors.lastname: Noël
authors.forename: Lei
authors.initials: L
authors.lastname: Gu
authors.forename: Patrick L
authors.initials: PL
authors.lastname: Heider
authors.forename: Klavs F
authors.initials: KF
authors.lastname: Jensen
mesh_terms: D002384:Catalysis; D055664:Electrochemical Techniques / Q000295:instrumentation* / Q000379:methods*; D056656:Lab-On-A-Chip Devices; D011138:Polytetrafluoroethylene
chemical_list: D011138:Polytetrafluoroethylene