title: Effect of genetic polymorphisms on the pharmacokinetics and efficacy of glimepiride in a Korean population.
abstract: BACKGROUND
  Glimepiride is a commonly used sulfonylurea hypoglycemic agent. There is considerable interindividual variation in the response to sulfonylurea for patients with type 2 diabetes. The purpose of this study was to investigate whether genetic variations influence the efficacy of glimepiride in healthy Korean subjects.
  
  
  METHODS
  A single 2-mg oral dose of glimepiride was administered to 46 healthy volunteers. Serial blood sampling for 12h after oral dosing was performed for determination of plasma glimepiride, glucose and insulin levels. We tested the association of seven single nucleotide polymorphisms (SNPs) in four candidate genes with the efficacy of glimepiride.
  
  
  RESULTS
  Pharmacodynamic profiles for plasma glucose and insulin showed no statistically significant differences among genotype groups, and parameters were not different from one another. There were no association of the KCNJ11, NOS1AP, TCF7L2 and ABCC8 gene polymorphisms and the efficacy of glimepiride.
  
  
  CONCLUSIONS
  Knowledge of these polymorphisms provides no clinical useful information for the pharmacogenetic therapeutic approach for Korean patients with type 2 diabetes.
authors.affiliation: Department of Laboratory Medicine, Konyang University Hospital, College of Medical Science Konyang University, Daejon, Republic of Korea.
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Cho
authors.forename: Soo-Youn
authors.initials: SY
authors.lastname: Lee
authors.forename: Youn-Gyoon
authors.initials: YG
authors.lastname: Kim
authors.forename: Soo-Yeon
authors.initials: SY
authors.lastname: Oh
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Wooseong
authors.initials: W
authors.lastname: Huh
authors.forename: Woo-Seong
authors.initials: WS
authors.lastname: Huh
authors.forename: Jae-Wook
authors.initials: JW
authors.lastname: Ko
authors.forename: Hyung-Gun
authors.initials: HG
authors.lastname: Kim
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007723:Korea; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013453:Sulfonylurea Compounds / Q000493:pharmacokinetics* / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds; C057619:glimepiride