title: Total synthesis of (±)-platencin.
abstract: A novel route to (±)-platencin is reported, in which the highly stereoselective alkylative quaternization of a cyclohexenone scaffold via 1,4-diastereoinduction and two radical carbon-carbon bond-forming reactions that involve titanium(III)-mediated cyclization and stannyl-radical-mediated skeletal rearrangement are utilized.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. yoshimit@phs.osaka-u.ac.jp
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yoshimitsu
authors.forename: Shoji
authors.initials: S
authors.lastname: Nojima
authors.forename: Masashi
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000627:Aminophenols / Q000138:chemical synthesis* / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000627:Aminophenols; D000900:Anti-Bacterial Agents; D011083:Polycyclic Compounds; C520340:platencin