title: Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study.
abstract: Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life.
authors.affiliation: Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee, USA.
authors.forename: Gwinnett
authors.initials: G
authors.lastname: Ladson
authors.forename: William C
authors.initials: WC
authors.lastname: Dodson
authors.forename: Stephanie D
authors.initials: SD
authors.lastname: Sweet
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Archibong
authors.forename: Allen R
authors.initials: AR
authors.lastname: Kunselman
authors.forename: Laurence M
authors.initials: LM
authors.lastname: Demers
authors.forename: Peter A
authors.initials: PA
authors.lastname: Lee
authors.forename: Nancy I
authors.initials: NI
authors.lastname: Williams
authors.forename: Ponjola
authors.initials: P
authors.lastname: Coney
authors.forename: Richard S
authors.initials: RS
authors.lastname: Legro
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D031204:Caloric Restriction; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008687:Metformin / Q000009:adverse effects / Q000627:therapeutic use*; D010865:Pilot Projects; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D040242:Risk Reduction Behavior; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
chemical_list: D015415:Biomarkers; D013739:Testosterone; D008687:Metformin