title: Influence of the 393T>C polymorphism of the GNAS1 gene on the intensity of opiate withdrawal.
abstract: There are high interindividual differences regarding the intensity of withdrawal symptoms. in opiate addicts. This study was carried out in order to test whether the intensity of withdrawal is influenced by the 393T>C polymorphism of the GNASI gene. Only patients addicted exclusively to opiates were included. Thirty-three out of 39 patients undergoing inpatient detoxification treatment achieved a drug-free state. During the most intense period of withdrawal (stop of methadone and following days) TT homozygotes (n=4) had a significantly higher pulse rate (primary outcome criterion) than C-allele carriers (n=29). This study and a previous study about GNB3 825C> T underline the possible role of G-protein polymorphisms in the interindividual variability of opiate withdrawal.
authors.forename: H S
authors.initials: HS
authors.lastname: Bachmann
authors.forename: B
authors.initials: B
authors.lastname: Lieb
authors.forename: U
authors.initials: U
authors.lastname: Bonnet
authors.forename: M
authors.initials: M
authors.lastname: Specka
authors.forename: S
authors.initials: S
authors.lastname: Augener
authors.forename: W
authors.initials: W
authors.lastname: Siffert
authors.forename: N
authors.initials: N
authors.lastname: Scherbaum
mesh_terms: D000328:Adult; D002864:Chromogranins; D005260:Female; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics*; D056726:Genetic Association Studies; D005858:Germany; D006556:Heroin Dependence / Q000628:therapy*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012720:Severity of Illness Index; D013375:Substance Withdrawal Syndrome / Q000235:genetics* / Q000503:physiopathology*
chemical_list: D002864:Chromogranins; C406732:GNAS protein, human; D019205:GTP-Binding Protein alpha Subunits, Gs