title: Chronic neutrophilic leukaemia: an Egyptian case.
abstract: Chronic neutrophilic leukaemia (CNL) is a rare myeloproliferative disorder of elderly patients characterised by sustained neutrophilia. The diagnosis of CNL requires the exclusion of BCR/ABL positive chronic myelogenous leukaemia and leukemoid reaction. We present here a case of a 61-year-old Egyptian man with CNL and 21 months of follow-up. The main symptom of our patient was purpura. Splenomegaly, hepatomegaly and lymph node enlargement were not detected at presentation or throughout the patient's course. Thrombocytopenia was a considerable problem in our patient, causing recurrent bleeding and affecting the hydroxyurea dose adjustment. While hydroxyurea decreased the total leucocytic count, it could not affect the fatal course of the disease. The survival course of our patient extended to 21 months after presentation. The cause of death was attributed to disease progression.
authors.affiliation: Graduate School of Medicine Kyoto University, Gastroenterology and Hepatology, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. bahrawy3@hotmail.com
authors.forename: Ashraf
authors.initials: A
authors.lastname: Elbahrawy
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Hamdy
authors.forename: Mohamed Hanafy
authors.initials: MH
authors.lastname: Morsy
authors.forename: Ramadan
authors.initials: R
authors.lastname: Ragab
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018450:Disease Progression; D004534:Egypt; D017809:Fatal Outcome; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D015467:Leukemia, Neutrophilic, Chronic / Q000175:diagnosis* / Q000188:drug therapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea