title: Diet high in oat β-glucan activates the gut-hypothalamic (PYY₃₋₃₆-NPY) axis and increases satiety in diet-induced obesity in mice.
abstract: This study tested the effects of (1→3),(1→4) β-D-glucan from oats, on activation of the gut-hypothalamic (PYY₃₋₃₆-NPY) axis, satiety, and weight loss in diet-induced obesity (DIO) mice. DIO mice were fed standard lab chow diets or varied doses of β-glucan for 6 weeks. Energy intake, satiety, body weight changes and peptide Y-Y₃₋₃₆ (PYY₃₋₃₆) were measured together with a satiety test and measurement of neuropeptide Y (NPY) mRNA expression in the hypothalamic arcuate nucleus (Arc). The average energy intake (-13%, p<0.05) and body weight gain was lower with increasing β-glucan over 6 wk with acute suppression of energy intake over 4 h. The highest β-glucan diet significantly increased plasma PYY₃₋₃₆, with suppression of Arc NPY mRNA.
authors.affiliation: School of Health Sciences, University of Wollongong, NSW, Australia.
authors.forename: Xu-Feng
authors.initials: XF
authors.lastname: Huang
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Yu
authors.forename: Eleanor J
authors.initials: EJ
authors.lastname: Beck
authors.forename: Tim
authors.initials: T
authors.lastname: South
authors.forename: Yulin
authors.initials: Y
authors.lastname: Li
authors.forename: Marijka J
authors.initials: MJ
authors.lastname: Batterham
authors.forename: Linda C
authors.initials: LC
authors.lastname: Tapsell
authors.forename: Jiezhong
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects / Q000378:metabolism; D018554:Avena / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects; D041981:Gastrointestinal Tract / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009478:Neuropeptide Y / Q000187:drug effects / Q000235:genetics; D009765:Obesity / Q000178:diet therapy / Q000503:physiopathology*; D010446:Peptide Fragments; D019894:Peptide YY / Q000032:analysis / Q000187:drug effects; D012333:RNA, Messenger; D012528:Satiety Response / Q000187:drug effects; D047071:beta-Glucans / Q000494:pharmacology*
chemical_list: D009478:Neuropeptide Y; D010446:Peptide Fragments; D012333:RNA, Messenger; D047071:beta-Glucans; D019894:Peptide YY; C061785:peptide YY (3-36); C067858:beta-glucan, (1-3)(1-4)-