title: Dry eye disease in chronic graft-versus-host disease: results from a Spanish retrospective cohort study.
abstract: We describe the incidence, clinical features, and final outcome of dry eye disease (DED) associated with chronic graft-versus-host disease (GVHD) over a 5-year period. We reviewed 109 clinical charts from patients undergoing hematopoietic stem cell transplantation (HSCT) between January 2000 and December 2005, abstracting data from the 57 patients who developed chronic GVHD and survived at least 180 days after allogenic HSCT. DED occurred in 22 (40%) patients at an average of 16.5 months after HSCT. Photophobia, irritation, and foreign body sensation were the most frequent symptoms, while punctate keratitis was the most common sign. DED tended to improve over time, with fewer than 5% of patients requiring more than two topical medications at the end of follow-up. Our study represented a formal evaluation of DED incidence among Spanish chronic GVHD patients. It is of utmost importance to assure patients will undergo a comprehensive ophthalmologic evaluation throughout their follow-up.
authors.affiliation: IOBA, Institute of Applied Ophthalmobiology, University of Valladolid, Valladolid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: de la Parra-Colín
authors.forename: A L D
authors.initials: AL
authors.lastname: Agahan
authors.forename: J A
authors.initials: JA
authors.lastname: Pérez-Simón
authors.forename: A
authors.initials: A
authors.lastname: López
authors.forename: D
authors.initials: D
authors.lastname: Caballero
authors.forename: E
authors.initials: E
authors.lastname: Hernández
authors.forename: T
authors.initials: T
authors.lastname: Barrientos-Gutierrez
authors.forename: M
authors.initials: M
authors.lastname: Calonge
mesh_terms: D000328:Adult; D002908:Chronic Disease; D015352:Dry Eye Syndromes / Q000150:complications*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies