title: Cell adhesion on explanted intraocular lenses part 2: experimental study of a surface-modified IOL in rabbits.
abstract: OBJECTIVE
  To develop a hydrophobic acrylic IOL with a hydrophilic, anti-cell adhesive surface characteristic.
  
  
  METHODS
  Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Hydrophobic acrylic IOLs were coated with hydrophilic 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer and implanted in rabbit eyes following lens extraction. Cell adhesion on the IOL surface was histologically compared with that on an uncoated IOL under light microscopy. Specimens were also observed under scanning electron microscopy to examine the effects of MPC coating on cell morphology.
  
  
  RESULTS
  Hydrophilic MPC coating reduced cell adhesion on acrylic IOLs at 1 month postoperatively.
  
  
  CONCLUSIONS
  Coating an acrylic IOL with a hydrophilic polymer inhibited cell adhesion on the IOL surface.
authors.affiliation: Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan. niskw@wakayama-med.ac.jp
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Yuka
authors.initials: Y
authors.lastname: Okada
authors.forename: Shizuya
authors.initials: S
authors.lastname: Saika
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002452:Cell Count; D020099:Coated Materials, Biocompatible; D015743:Giant Cells, Foreign-Body / Q000378:metabolism* / Q000648:ultrastructure; D057927:Hydrophobic and Hydrophilic Interactions; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008264:Macrophages / Q000378:metabolism* / Q000648:ultrastructure; D008689:Methacrylates / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D008689:Methacrylates; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine