title: [Acute effects of IL-1β on sodium current in cortical neurons of rats].
abstract: Interleukin-1β (IL-1β) is an important proinflammatory cytokine that plays a key role in injuries and diseases of the central nervous system (CNS). The voltage-gated Na(+) channel is the most important ion channel of neurons, and is essential for regenerative action potential (AP). The Na(+) channel also contributes to many diseases of the brain. However, relations between IL-1β and central Na(+) channels remain unreported. In this study, whole cell patch-clamp recording was used to investigate the acute effects of IL-1β (10 ng/mL) on voltage-dependent Na(+) currents and AP of cultured cortical neurons from rats. Results showed that the half-activation voltage of Na(+) channels and the threshold of AP, but not the amplitude, slope factor of activation, and inactivation properties, were affected by IL-1β. These data suggest that increased IL-1β in injury and disease may upregulate the excitability of neurons, and thereby exacerbate neurotoxicity.
authors.affiliation: College of Life Sciences, Hebei University, Baoding 071002, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Qi
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Chao-Fei
authors.initials: CF
authors.lastname: Bao
authors.forename: Xin-Wei
authors.initials: XW
authors.lastname: Wang
authors.forename: Xiao-Nan
authors.initials: XN
authors.lastname: Li
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Yu
authors.forename: Chen
authors.initials: C
authors.lastname: Zhou
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D055724:Electrophysiological Phenomena; D005260:Female; D053583:Interleukin-1beta / Q000494:pharmacology*; D009474:Neurons / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D015222:Sodium Channels / Q000502:physiology
chemical_list: D053583:Interleukin-1beta; D015222:Sodium Channels