title: Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review.
abstract: Aminoethylcysteine ketimine decarboxylated dimer is a natural sulfur-containing compound detected in human plasma and urine, in mammalian brain and in many common edible vegetables. Over the past decade many studies have been undertaken to identify its metabolic role. Attention has been focused on its antioxidant properties and on its reactivity against oxygen and nitrogen reactive species. These properties have been studied in different model systems starting from plasma lipoproteins to specific cellular lines. All these studies report that aminoethylcysteine ketimine decarboxylated dimer is able to interact both with reactive oxygen and nitrogen species (hydrogen peroxide, superoxide anion, hydroxyl radical, peroxynitrite and its derivatives). Its antioxidant activity is similar to that of Vitamin E while higher than other hydrophilic antioxidants, such as trolox and N-acetylcysteine.
authors.affiliation: Department of Biochemical Sciences, Sapienza, University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy; E-Mails: alberto.macone@uniroma1.it (A.M.); mario.fontana@uniroma1.it (M.F.); laura.pecci@uniroma1.it (L.P.).
authors.forename: Alberto
authors.initials: A
authors.lastname: Macone
authors.forename: Mario
authors.initials: M
authors.lastname: Fontana
authors.forename: Marco
authors.initials: M
authors.lastname: Barba
authors.forename: Bruno
authors.initials: B
authors.lastname: Botta
authors.forename: Mirella
authors.initials: M
authors.lastname: Nardini
authors.forename: Francesca
authors.initials: F
authors.lastname: Ghirga
authors.forename: Andrea
authors.initials: A
authors.lastname: Calcaterra
authors.forename: Laura
authors.initials: L
authors.lastname: Pecci
authors.forename: Rosa Marina
authors.initials: RM
authors.lastname: Matarese
mesh_terms: D016166:Free Radical Scavengers / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D009025:Morpholines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D026361:Reactive Nitrogen Species / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry
chemical_list: C086349:5,9a-dihydro-5-oxopyrrolo(2,1-c-3,4-b')dithiomorpholine; D016166:Free Radical Scavengers; D009025:Morpholines; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D013455:Sulfur