title: Osteonecrosis of the femoral head and glaucoma caused by topical corticosteroid application.
abstract: A 37-year-old man was diagnosed with bilateral osteonecrosis of the femoral head (ONFH) and glaucoma. He had no risk factors for either ONFH or glaucoma, except for 24 years' continuous use of topical corticosteroid ointments for treating atopic dermatitis. We determined that the topical steroid had caused both the pathological conditions. It is necessary to recognize that continuous topical corticosteroid therapy may cause the same pathological conditions as those caused by the systemic administration of these agents.
authors.affiliation: Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8641, Japan. tamonkabata@aol.com
authors.forename: Tamon
authors.initials: T
authors.lastname: Kabata
authors.forename: Keito
authors.initials: K
authors.lastname: Shimanuki
authors.forename: Kiichi
authors.initials: K
authors.lastname: Shimanuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuchiya
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D005270:Femur Head / Q000473:pathology*; D005901:Glaucoma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D009824:Ointments / Q000009:adverse effects / Q000627:therapeutic use; D010020:Osteonecrosis / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D009824:Ointments