title: [A case of multifocal micronodular pneumocyte hyperplasia without clinical findings of tuberous sclerosis].
abstract: A 30-year-old woman was referred because of multiple ground-glass opacities (GGOs) on chest CT examination. Lung biopsy was performed. Histologically, multifocal well-demarcated nodular lesions comprising proliferation of type II pneumocytes with mild fibrous thickening of the alveolar septa were observed in the lung tissue. We made a histopathologic diagnosis of multifocal micronodular pneumocyte hyperplasia (MMPH). Neither the clinical findings nor the family history of the patient suggested tuberous sclerosis (TSC). MMPH is a pulmonary manifestation of tuberous sclerosis, together with lymphangioleiomyomatosis (LAM). MMPH should be considered as a differential diagnosis of multiple GGOs in the lung even when findings of TSC and LAM are not recognized.
authors.affiliation: "First Department of Medicine, Hokkaido University School of Medicine.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Taniguchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Konno
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nasuhara
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsuno
authors.forename: Teruaki
authors.initials: T
authors.lastname: Oka
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D056809:Alveolar Epithelial Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008168:Lung / Q000000981:diagnostic imaging; D011859:Radiography; D014402:Tuberous Sclerosis / Q000175:diagnosis