title: CT nonuniform attenuation and TEW scatter corrections in brain Tc-99m ECD SPECT.
abstract: Perfusion brain single photon emission computed tomography (SPECT) is currently used to evaluate patients with cognitive impairments. Although widely available, it has been reported to be significantly less sensitive than F-18 FDG positron emission tomography. Optimization of SPECT parameters using nonuniform attenuation correction (NUAC) and scatter correction (SC) might improve the accuracy of the method. This study assessed the effect of x-ray CT-based NUAC and triple-energy window (TEW-SC) on brain SPECT compared with Chang-uniform (UAC). A total of 31 patients with memory complaints underwent Tc-99m ECD SPECT/CT. CT-NUAC+TEW-SC and Chang-UAC were applied and compared. The images were spatially normalized to a default SPECT template supplied with Statistical Parametric Mapping software (SPM2). A paired t test image was then reconstructed. Regional cerebral blood flow measurements were apparently reduced in the frontal white-matter and in the frontotemporal cortex when CT-NUAC+TEW-SC were used. These findings need to be considered when interpreting Tc-99m ECD SPECT after applying CT-AC+TEW-SC. Further prospective studies with clinical correlations are needed.
authors.affiliation: AP-HP, Hôpital Hôtel Dieu, service de Médecine Nucléaire, Paris, France. karim.farid@htd.aphp.fr
authors.forename: Karim
authors.initials: K
authors.lastname: Farid
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Habert
authors.forename: Antoine
authors.initials: A
authors.lastname: Martineau
authors.forename: Nadine
authors.initials: N
authors.lastname: Caillat-Vigneron
authors.forename: Igor
authors.initials: I
authors.lastname: Sibon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D008875:Middle Aged; D015609:Organotechnetium Compounds; D012189:Retrospective Studies; D012542:Scattering, Radiation; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine