title: Long-term time course of affective lability after subthalamic deep brain stimulation electrode implantation.
abstract: The mechanism and time course of emotional side effects of subthalamic deep brain stimulation in Parkinson's disease are a matter for discussion. We report a 53-month follow-up of a patient with affective lability. Postoperative lesion plus bilateral stimulation strongly influenced mood in the first week in terms of laughing behavior, while voltage changes had only minor long-term impact up to 37 months on negative emotion, possibly caused by the right electrode stimulating the subthalamic nucleus and adjacent fiber tracts involving the internal capsule. Thus we conclude that affective lability can occur with different temporal dynamics of microlesion, and early and chronic stimulation.
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology & Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany. wojtecki@uni-duesseldorf.de
authors.forename: Lars
authors.initials: L
authors.lastname: Wojtecki
authors.forename: Lars
authors.initials: L
authors.lastname: Timmermann
authors.forename: Stefan Jun
authors.initials: SJ
authors.lastname: Groiss
authors.forename: Saskia
authors.initials: S
authors.lastname: Elben
authors.forename: Christiane
authors.initials: C
authors.lastname: Reck
authors.forename: Martin
authors.initials: M
authors.lastname: Südmeyer
authors.forename: Volker
authors.initials: V
authors.lastname: Sturm
authors.forename: Alfons
authors.initials: A
authors.lastname: Schnitzler
mesh_terms: D000342:Affective Symptoms / Q000209:etiology*; D000368:Aged; D003448:Crying; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D004566:Electrodes; D004644:Emotions; D005500:Follow-Up Studies; D006801:Humans; D020772:Internal Capsule; D007845:Laughter; D008297:Male; D010300:Parkinson Disease / Q000628:therapy*; D020531:Subthalamic Nucleus; D013997:Time Factors