title: [Effect of buprenorphine on postoperative analgesia following remifentanil-based anesthesia].
abstract: BACKGROUND
  It is well known that buprenorphine compete with remifentanil for receptor binding. I have examined the effect of buprenorphine administration on postoperative analgesia following remifentanil-based anesthesia.
  
  
  METHODS
  In this study, I enrolled 30 patients who had undergone open reduction and internal fixation for fractures at the extremities under general anesthesia. Anesthesia was maintained with continuous infusion of remifentanil, and buprenorphine was administered at the end of surgery. Postoperative pain and side effects were evaluated in all patients.
  
  
  RESULTS
  Seventeen patients (57%) required additional analgesic treatment within 1 hour of initial administration of buprenorphine. Buprenorphine therapy in patients who had undergone lower limb surgery was not as effective as that in patients who had undergone upper limb surgery. Incidence of nausea and vomiting in the study population was high(37%).
  
  
  CONCLUSIONS
  Buprenorphine is effective to some degree as a postoperative analgesic following remifentanil-based anesthesia, but is not sufficient in cases of severe postoperative pain.
authors.affiliation: Department of Anesthesiology, Sano Kinen Hospital, Izumisano 598-0013.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kimoto
mesh_terms: D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use*; D000768:Anesthesia, General; D002047:Buprenorphine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005593:Fracture Fixation, Internal; D006801:Humans; D035002:Lower Extremity / Q000293:injuries / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010880:Piperidines; D000077208:Remifentanil; D034941:Upper Extremity / Q000293:injuries / Q000601:surgery
chemical_list: D000701:Analgesics, Opioid; D010880:Piperidines; D002047:Buprenorphine; D000077208:Remifentanil