title: Cyclooxygenase-1 is involved in the inhibition of hippocampal neurogenesis after lipopolysaccharide-induced neuroinflammation.
abstract: Growing evidence indicates that neuroinflammation can alter adult neurogenesis by mechanisms as yet unclear. We have previously demonstrated that the neuroinflammatory response and neuronal damage after lipopolysaccharide (LPS) injection is reduced in cyclooxygenase-1 deficient (COX-1(-/-)) mice. In this study, we investigated the role of COX-1 on hippocampal neurogenesis during LPS-induced neuroinflammation, using COX-1(-/-) and wild type (WT) mice. We found that LPS-induced neuroinflammation resulted in the decrease of proliferation, survival and differentiation of hippocampal progenitor cells in WT but not in COX-1(-/-) mice. Thus, we demonstrate for the first time that COX-1 is involved in the inhibition of BrdU progenitor cells in proliferation and hippocampal neurogenesis after LPS. These results suggest that COX-1 may represent a viable therapeutic target to reduce neuroinflammation and promote neurogenesis in neurodegenerative diseases with a strong inflammatory component.
authors.affiliation: Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, NIH, Bethesda, MD, USA.
authors.forename: Isabella
authors.initials: I
authors.lastname: Russo
authors.forename: Panomwat
authors.initials: P
authors.lastname: Amornphimoltham
authors.forename: Roberto
authors.initials: R
authors.lastname: Weigert
authors.forename: Sergio
authors.initials: S
authors.lastname: Barlati
authors.forename: Francesca
authors.initials: F
authors.lastname: Bosetti
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D051545:Cyclooxygenase 1 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004660:Encephalitis / Q000139:chemically induced* / Q000201:enzymology; D006624:Hippocampus / Q000166:cytology* / Q000201:enzymology; D007249:Inflammation / Q000139:chemically induced; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D018345:Mice, Knockout; D055495:Neurogenesis; D013234:Stem Cells / Q000166:cytology
chemical_list: D008070:Lipopolysaccharides; D051545:Cyclooxygenase 1