title: Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives.
abstract: Two novel series of hydrazinyl thiazolyl coumarin derivatives have been synthesized and fully characterized by IR, (1)H NMR, (13)C NMR, elemental analysis and mass spectral data. The structures of some compounds were further confirmed by X-ray crystallography. All of these derivatives, 10a-d and 15a-h, were screened in vitro for antimicrobial activity against various bacteria species including Mycobacterium tuberculosis and Candida albicans. The compounds 10c, 10d and 15e exhibited very good activities against all of the tested microbial strains.
authors.affiliation: School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
authors.forename: Afsheen
authors.initials: A
authors.lastname: Arshad
authors.forename: Hasnah
authors.initials: H
authors.lastname: Osman
authors.forename: Mark C
authors.initials: MC
authors.lastname: Bagley
authors.forename: Chan Kit
authors.initials: CK
authors.lastname: Lam
authors.forename: Suriyati
authors.initials: S
authors.lastname: Mohamad
authors.forename: Anis Safirah Mohd
authors.initials: AS
authors.lastname: Zahariluddin
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D003374:Coumarins; D013844:Thiazoles; C030123:coumarin