title: High fat diet intake during pre and periadolescence impairs learning of a conditioned place preference in adulthood.
abstract: BACKGROUND
  Brain regions that mediate learning of a conditioned place preference (CPP) undergo significant development in pre and periadolescence. Consuming a high fat (HF) diet during this developmental period and into adulthood can lead to learning impairments in rodents. The present study tested whether HF diet intake, consumed only in pre and periadolescence, would be sufficient to cause impairments using a CPP procedure.
  
  
  METHODS
  Rats were randomly assigned to consume a HF or a low fat (LF) diet during postnatal days (PD) 21-40 and were then placed back on a standard lab chow diet. A 20-day CPP procedure, using HF Cheetos® as the unconditioned stimulus (US), began either the next day (PD 41) or 40 days later (PD 81). A separate group of adult rats were given the HF diet for 20 days beginning on PD 61, and then immediately underwent the 20-day CPP procedure beginning on PD 81.
  
  
  RESULTS
  Pre and periadolescent exposure to a LF diet or adult exposure to a HF diet did not interfere with the development of a HF food-induced CPP, as these groups exhibited robust preferences for the HF Cheetos® food-paired compartment. However, pre and periadolescent exposure to the HF diet impaired the development of a HF food-induced CPP regardless of whether it was assessed immediately or 40 days after the exposure to the HF diet, and despite showing increased consumption of the HF Cheetos® in conditioning.
  
  
  CONCLUSIONS
  Intake of a HF diet, consumed only in pre and periadolescence, has long-lasting effects on learning that persist into adulthood.
authors.affiliation: Department of Psychology, Saint Bonaventure University, 3261 West State Street, Saint Bonaventure, NY 14778, USA. gprivite@sbu.edu
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Privitera
authors.forename: Arturo R
authors.initials: AR
authors.lastname: Zavala
authors.forename: Federico
authors.initials: F
authors.lastname: Sanabria
authors.forename: Kristin L
authors.initials: KL
authors.lastname: Sotak
mesh_terms: D000367:Age Factors; D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology*; D059305:Diet, High-Fat / Q000009:adverse effects*; D002149:Energy Intake / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley