title: Acute myeloid leukaemia (M6B: pure acute erythroid leukaemia) in a Thoroughbred foal.
abstract: A 10-week-old Thoroughbred filly was referred for anaemia of 4 weeks' duration. Haematology revealed severe anaemia and panleucopenia. Cytological examination of bone marrow smears revealed a myeloid to erythroid ratio <0.02:1 (reference range 0.5-2.4:1.0) and an abundance of erythroid precursor cells. The erythroid cell population included rubriblasts, prorubricytes and rubricytes, with only scant numbers of metarubricytes present. There were numerous mitotic erythroid cells, some of which were atypical and megaloblastic. These cytomorphological changes are consistent with pure acute erythroid leukaemia. No treatment was instituted and the filly died three days after presentation. This case illustrates the need to consider both haematology and bone marrow findings to establish a diagnosis of pure erythroid leukaemia. To our knowledge, there is no documented case of acute myeloproliferative disease in horses involving cells of erythroid lineage, but this condition should be considered a differential diagnosis for horses presenting with anaemia.
authors.affiliation: Equine Centre, Veterinary Clinic and Hospital, University of Melbourne, Werribee, Victoria, Australia. gforbes@unimelb.edu.au
authors.forename: G
authors.initials: G
authors.lastname: Forbes
authors.forename: D J
authors.initials: DJ
authors.lastname: Feary
authors.forename: C J
authors.initials: CJ
authors.lastname: Savage
authors.forename: L
authors.initials: L
authors.lastname: Nath
authors.forename: S
authors.initials: S
authors.lastname: Church
authors.forename: P
authors.initials: P
authors.lastname: Lording
mesh_terms: D000818:Animals; D004913:Erythrocytes, Abnormal; D015672:Erythroid Precursor Cells / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006734:Horse Diseases / Q000097:blood / Q000473:pathology*; D006736:Horses; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood / Q000473:pathology / Q000662:veterinary*