title: Relationship of protein and calorie intake to the severity of oral mucositis in patients with head and neck cancer receiving radiation therapy.
abstract: BACKGROUND
  The purpose of this study was to evaluate the relationship of calorie and protein intake to the severity of oral mucositis in patients with head and neck cancer receiving radiation therapy.
  
  
  METHODS
  Patients with head and neck cancer undergoing ≥60 Gy of radiation were eligible. Weekly data were collected for oral mucositis grade and protein and calorie intake. Proportional odds models examined the association of oral mucositis severity with nutritional predictors.
  
  
  RESULTS
  During a 24-month period, 40 evaluable patients met criteria for inclusion. In a multivariate backward selection model, the sole significant nutritional predictor of reduced oral mucositis severity was meeting the protein goal for the current week (p = .01; adjusted odds ratio [OR], 2.30).
  
  
  CONCLUSIONS
  Patients who met protein-related goals during radiotherapy for head and neck cancer had less severe oral mucositis. Nutritional counseling during radiotherapy, with emphasis on protein goals, may reduce oral mucositis severity.
authors.affiliation: Department of Internal Medicine, University of New Mexico Cancer Center, Albuquerque, New Mexico, USA. klzahn@salud.unm.edu
authors.forename: Karen L
authors.initials: KL
authors.lastname: Zahn
authors.forename: Gene
authors.initials: G
authors.lastname: Wong
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Bedrick
authors.forename: Deborah G
authors.initials: DG
authors.lastname: Poston
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Schroeder
authors.forename: Julie E
authors.initials: JE
authors.lastname: Bauman
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D017024:Chemotherapy, Adjuvant; D015930:Diet Records; D004044:Dietary Proteins / Q000008:administration & dosage*; D019583:Dose Fractionation, Radiation; D002149:Energy Intake; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects; D050397:Radiotherapy, Intensity-Modulated; D012720:Severity of Illness Index; D013280:Stomatitis / Q000178:diet therapy* / Q000209:etiology
chemical_list: D004044:Dietary Proteins