title: The effect of dilute baby shampoo on nasal mucociliary clearance in healthy subjects.
abstract: BACKGROUND
  Biofilm formation has been implicated as an etiologic factor in the development of chronic rhinosinusitis (CRS). Nasal irrigation with surfactants including dilute baby shampoo have been proposed as an antibiofilm treatment for CRS patients. The effect of dilute baby shampoo on normal sinonasal mucosal function is unknown.
  
  
  METHODS
  Mucociliary clearance time (MCT), as measured by the time in minutes for a subject to detect a sweet taste after the application of a saccharin granules at the anterior part of the inferior turbinate, was performed before and shortly after nasal irrigation with 50 ml of 1% baby shampoo (Johnson & Johnson, New Brunswick, NJ) in 27 healthy volunteers.
  
  
  RESULTS
  Mean MCTs before and after irrigation were 12.09 (±4.83 minutes) and 15.45 (±7.71 minutes) minutes, respectively. The mean difference, 3.37 minutes, was statistically significant (p = 0.031). Pre- and post-MCTs for each subject were not correlated (r = 0.324; p = 0.100).
  
  
  CONCLUSIONS
  Nasal irrigations with dilute baby shampoo increase MCTs in healthy subjects. The impact of such interventions in CRS patients warrants additional investigation.
authors.affiliation: Cincinnati Sinus Institute, Cincinnati, Ohio, USA.
authors.forename: Seth
authors.initials: S
authors.lastname: Isaacs
authors.forename: Samer
authors.initials: S
authors.lastname: Fakhri
authors.forename: Amber
authors.initials: A
authors.lastname: Luong
authors.forename: Chad
authors.initials: C
authors.lastname: Whited
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Citardi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001424:Bacterial Infections / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control; D018441:Biofilms; D002908:Chronic Disease; D005260:Female; D006203:Hair Preparations / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects; D009666:Nose / Q000187:drug effects / Q000473:pathology; D012220:Rhinitis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D012852:Sinusitis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D013501:Surface-Active Agents / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000890:Anti-Infective Agents; D006203:Hair Preparations; D013501:Surface-Active Agents