title: Antidiabetic and hypolipidemic effects of different fractions of Coccinia cordifolia L. on normal and streptozotocin-induced diabetic rats.
abstract: The present study was carried out to observe the antidiabetic and hypolipidemic effects of petroleum-ether, ethyl acetate and chloroform fractions isolated from ethanolic extract of the leaves of Coccinia cordifolia Linn. (150 mg/kg body weight) on normal and streptozotocin (STZ)-induced diabetic rats for one day experiment. Single doses (150 mg/kg, i.p.) of C. cordifolia extracts were given to normal and diabetic rats. The fasting blood glucose (FBG), serum triglyceride (TG) and serum total cholesterol (TC) levels were investigated in normal and STZ-diabetic rats on 0, 1, 2, 3, 6, 10, 16, and 24th hours. In normoglycemic rats the pet-ether and ethyl acetate fractions of C. cordifolia reduced blood glucose level significantly (39.66% and 40.68% at 16th and 24th hour respectively). In the STZ-diabetic rats pet-ether and ethyl acetate fractions also reduced blood glucose level significantly (50.39% and 50% at 10th and 24th hour respectively). Ethyl acetate fraction is most effective which reduced total cholesterol level by 31.04% and 36.69% in normal and STZ-diabetic rats respectively. Ethyl acetate fraction reduced triglyceride level by 43.82% and 42.01% in normal and STZ-diabetic rats respectively. Our results indicate that pet-ether and ethyl acetate fractions of C. cordifolia have potentiality against diabetes.
authors.affiliation: Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh.
authors.forename: Md Ariful
authors.initials: MA
authors.lastname: Islam
authors.forename: Md Rafiqul-Islam
authors.initials: MR
authors.lastname: Khan
authors.forename: Md Sarowar
authors.initials: MS
authors.lastname: Hossain
authors.forename: A H M Khurshid
authors.initials: AH
authors.lastname: Alam
authors.forename: Mir Imam
authors.initials: MI
authors.lastname: Ibne-Wahed
authors.forename: Bytul M
authors.initials: BM
authors.lastname: Rahman
authors.forename: Asm Anisuz
authors.initials: AA
authors.lastname: Zaman
authors.forename: Sharif Md
authors.initials: SM
authors.lastname: Shaheen
authors.forename: Maruf
authors.initials: M
authors.lastname: Ahmed
mesh_terms: D000085:Acetates / Q000737:chemistry; D000473:Alkanes / Q000737:chemistry; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002725:Chloroform / Q000737:chemistry; D002784:Cholesterol / Q000097:blood; D019662:Cucurbitaceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D005260:Female; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D020318:Rats, Long-Evans; D014280:Triglycerides / Q000097:blood
chemical_list: D000085:Acetates; D000473:Alkanes; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014280:Triglycerides; C007650:ethyl acetate; D002725:Chloroform; D002784:Cholesterol; C004544:naphtha