title: Cramer-Rao analysis of steady-state and time-domain fluorescence diffuse optical imaging.
abstract: Using a Cramer-Rao analysis, we study the theoretical performances of a time and spatially resolved fDOT imaging system for jointly estimating the position and the concentration of a point-wide fluorescent volume in a diffusive sample. We show that the fluorescence lifetime is a critical parameter for the precision of the technique. A time resolved fDOT system that does not use spatial information is also considered. In certain cases, a simple steady-state configuration may be as efficient as this time resolved fDOT system.
authors.forename: M
authors.initials: M
authors.lastname: Boffety
authors.forename: M
authors.initials: M
authors.lastname: Allain
authors.forename: A
authors.initials: A
authors.lastname: Sentenac
authors.forename: M
authors.initials: M
authors.lastname: Massonneau
authors.forename: R
authors.initials: R
authors.lastname: Carminati