title: [First experience of using CoolGard system in intensive care patients after neurosurgical interventions: series of 10 observations].
abstract: Fever is a proven factor in secondary brain damage and worsens outcome in neuro intensive care patients. However, large randomized studies have shown neuroprotective effects of induced hypothermia only in patients with cardiac arrest and in neonates with perinatal hypoxic-ischemic brain damage. Nevertheless, now there is an active search for alternative modes of temperature correction, which would have been effective in other groups of patients with brain damage. Moreover, new management techniques of body temperature are being created. In this paper we presented a series of 10 observations when the used cooling system was CoolGard/CoolLine. 5 patients underwent hypothermia, 5 patients normothermia . Hypothermia was used for cerebroprotection in 1 case and for the correction of resistance to the therapy of intracranial hypertension in 4 cases. Normothermia was used for correction of resistance to pharmacological treatment of fever. In all cases the target temperature was achieved, and only for 1 patient to achieve hypothermia additional external cooling was used. Patients with normothermia did not need sedation, because they have not developed discomfort and muscle tremor. 2 patients died, in one case was due to intracranial hypertension and hemotamponade of brain ventricular system. Cause of second death was pulmonary embolism. Thus, the CoolGard system effectively lowers the body temperature to the target values for neuro intensive care patients. Application of this system is relatively safe. However, the most dangerous are the thromboembolic complications, thus the daily ultrasound scanning of lower limb veins and the possible early use of low molecular weight heparins is crucial.
authors.forename: K A
authors.initials: KA
authors.lastname: Popugaev
authors.forename: I A
authors.initials: IA
authors.lastname: Savin
authors.forename: A S
authors.initials: AS
authors.lastname: Goriachev
authors.forename: A V
authors.initials: AV
authors.lastname: Oshorov
authors.forename: N V
authors.initials: NV
authors.lastname: Kurdiumova
authors.forename: A A
authors.initials: AA
authors.lastname: Sychev
authors.forename: A A
authors.initials: AA
authors.lastname: Polupan
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Sokolova
authors.forename: A M
authors.initials: AM
authors.lastname: Tseĭtlin
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Lubnin
mesh_terms: D000293:Adolescent; D000328:Adult; D002545:Brain Ischemia / Q000209:etiology / Q000517:prevention & control*; D002648:Child; D003422:Critical Care / Q000379:methods; D005260:Female; D005334:Fever / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007036:Hypothermia, Induced / Q000295:instrumentation / Q000379:methods*; D019586:Intracranial Hypertension / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome