title: Immune effects of trastuzumab.
abstract: Trastuzumab's targeted therapy has become a stronghold for human epidermal growth factor receptor 2 positive breast cancer patients. This humanized monoclonal antibody binds to the extracellular juxta-membrane domain of HER2 and inhibits the proliferation and survival of HER2 dependent cancer cells. The ways by which this molecule exerts its action have been partially elucidated but several new mechanisms are being constantly identified. Several new agents are being introduced that interfere with HER2. Several new immunotherapy strategies are being introduced in order to direct the immune system against cells and tissues that aberrantly overexpressed HER2. We review the strategies currently adopted and those suggested against HER2 expressing tumors.
authors.affiliation: "Sapienza" University of Rome, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Nuti
authors.forename: Filippo
authors.initials: F
authors.lastname: Bellati
authors.forename: Valeria
authors.initials: V
authors.lastname: Visconti
authors.forename: Chiara
authors.initials: C
authors.lastname: Napoletano
authors.forename: Lavinia
authors.initials: L
authors.lastname: Domenici
authors.forename: Jlenia
authors.initials: J
authors.lastname: Caccetta
authors.forename: Ilaria Grazia
authors.initials: IG
authors.lastname: Zizzari
authors.forename: Ilary
authors.initials: I
authors.lastname: Ruscito
authors.forename: Hassan
authors.initials: H
authors.lastname: Rahimi
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Benedetti-Panici
authors.forename: Aurelia
authors.initials: A
authors.lastname: Rughetti