title: The evolving plasticity of coagulation protease-dependent cytoprotective signalling.
abstract: Coagulation proteases control cellular homeostasis beyond haemostasis. While the role of coagulation proteases in regulating vascular healing and thrombosis is well established, the mechanism underlying the receptor-dependent regulation of cellular function remain incompletely understood. In particular, the opposing effects of the protease-activated receptor 1 (PAR-1), dependent on the activating proteases thrombin or activated protein C generated a conundrum researchers only recently have begun to decipher. The net-effect (cellular perturbation vs. cellular protection) depends on co-receptors involved, the concentration of the activating protease, the temporal context of receptor activation, and a dynamic process of receptor rearrangement upon receptor activation. The latter scenario recruits receptors to a cytoprotective signalling pathways. Recent insights into these mechanisms are summarized in this article.
authors.affiliation: University of Heidelberg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Shahzad
authors.forename: B
authors.initials: B
authors.lastname: Isermann
mesh_terms: D000222:Adaptation, Physiological / Q000276:immunology*; D000818:Animals; D001777:Blood Coagulation / Q000276:immunology*; D001808:Blood Vessels / Q000166:cytology / Q000276:immunology*; D019610:Cytoprotection / Q000276:immunology*; D006487:Hemostasis / Q000276:immunology*; D006801:Humans; D008955:Models, Cardiovascular; D018448:Models, Immunological; D010447:Peptide Hydrolases / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D010447:Peptide Hydrolases