title: Semi-synthesis of a protease-activatable collagen targeting probe.
abstract: A protease-activatable collagen targeting probe (proCNA35) is synthesized by conjugation of a synthetic collagen fragment to the collagen binding protein CNA35 via a protease-cleavable linker. Cleavage of the linker by MMP1 releases the intramolecular inhibition of the collagen binding site and restores its collagen binding capacity.
authors.affiliation: Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: Monica
authors.initials: M
authors.lastname: Breurken
authors.forename: Edith H M
authors.initials: EH
authors.lastname: Lempens
authors.forename: E W
authors.initials: EW
authors.lastname: Meijer
authors.forename: Maarten
authors.initials: M
authors.lastname: Merkx
mesh_terms: D000818:Animals; D003094:Collagen / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D008958:Models, Molecular; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011485:Protein Binding; D017433:Protein Structure, Secondary
chemical_list: D010446:Peptide Fragments; D003094:Collagen; D010447:Peptide Hydrolases