title: Multiparity causes uncoordinated activity of pelvic- and perineal-striated muscles and urodynamic changes in rabbits.
abstract: Temporal and coordinated activation of pelvic- (pubococcygeous) and perineal- (bulbospongiosus and ischiocavernosus) striated muscles occurs during micturition in female rabbits. We have hypothesized that the coordinated activation of pelvic and perineal muscles is modified during the micturition of young multiparous rabbits. Young virgin and multiparous female chinchilla rabbits were used to simultaneously record cystometrograms and electromyograms of the pubococcygeous, ischocavernosus, and bulbospongiosus muscles. Bladder function was assessed using standard urodynamic variables. The temporal coordination of pelvic- and perineal-striated muscle activity was changed in multiparous rabbits. The cystometrogram recordings were different than those obtained from virgin rabbits, as seen in alterations of the threshold volume, the residual volume, the voiding duration, and the maximum pressure. In rabbits, we find that multiparity causes uncoordinated activity of pubococcygeous, ischiocavernosus, and bulbospongiosus muscles and modifies the urodynamics.
authors.affiliation: Depto. de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF, México. marmag@biomedicas.unam.mx
authors.forename: Margarita
authors.initials: M
authors.lastname: Martínez-Gómez
authors.forename: Germán
authors.initials: G
authors.lastname: Mendoza-Martínez
authors.forename: Dora Luz
authors.initials: DL
authors.lastname: Corona-Quintanilla
authors.forename: Víctor
authors.initials: V
authors.lastname: Fajardo
authors.forename: Jorge
authors.initials: J
authors.lastname: Rodríguez-Antolín
authors.forename: Francisco
authors.initials: F
authors.lastname: Castelán
mesh_terms: D000818:Animals; D004576:Electromyography; D005260:Female; D018482:Muscle, Skeletal / Q000502:physiology*; D010298:Parity; D017773:Pelvic Floor / Q000503:physiopathology*; D010502:Perineum; D011247:Pregnancy; D011312:Pressure; D011817:Rabbits; D013997:Time Factors; D001743:Urinary Bladder / Q000503:physiopathology*; D014550:Urinary Incontinence, Stress / Q000209:etiology / Q000503:physiopathology*; D014554:Urination; D014563:Urodynamics