title: Role of unusual CD4+ CD28- T cells in acute coronary syndrome.
abstract: Acute coronary syndrome (ACS) is a group of clinical symptoms that results from complete or partial occlusive thrombus, which is caused by coronary an atherosclerotic plaque rupture or erosion. According to a recent study, CD4(+) CD28(-) T cells are found in atherosclerotic plaques and the peripheral circulation blood in patients with ACS, these cells play an important role in plaque ruptures. CD4(+) CD28(-) T cells are an unusual subset of helper cells, which expand and have harmful effects in ACS. In this review, we discuss the current issues on the generation of CD4(+) CD28(-) T cells and focus on their phenotypic and functional characteristics relevant to the development of cardiovascular events. Targeting the CD4(+) CD28(-) T cells subset in ACS could provide novel therapeutic means to prevent acute life-threatening coronary events.
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, People's Republic of China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Sun
authors.forename: Lihui
authors.initials: L
authors.lastname: Zheng
authors.forename: Lijuan
authors.initials: L
authors.lastname: Huang
mesh_terms: D054058:Acute Coronary Syndrome / Q000276:immunology* / Q000473:pathology*; D018106:CD28 Antigens / Q000172:deficiency*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D049109:Cell Proliferation; D000939:Epitopes; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D058226:Plaque, Atherosclerotic / Q000276:immunology*
chemical_list: D018106:CD28 Antigens; D000939:Epitopes