title: Early gastric cancer in Menetrier's disease.
abstract: Uncommon conditions such as pernicious anaemia and hypertrophic gastropathies have been considered as risk factors for gastric cancer; however, the exact increase in risk is unknown. Menetrier's disease is a rare hyperproliferative disorder of the stomach caused by an overexpression of tumour growth factor α, a ligand for the tyrokinase epidermal growth factor receptor, resulting in a selective expansion of surface mucous cells in the body and fundus of the stomach. There have been nearly 200 cases of Menetrier's disease reported in the literature yet less than 15 have been associated with gastric adenocarcinoma. Here, we report an early stage gastric adenocarcinoma detected incidentally in a patient recently diagnosed with Menetrier's disease.
authors.affiliation: Instituto de Investigaciones Medico Biologicas, Laboratorio de Fisiologia Digestiva y Motilidad. Iturbide SN, Col. Flores Magon, Veracruz 91400, Mexico.
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Remes-Troche
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Zapata-Colindres
authors.forename: Ivethe
authors.initials: I
authors.lastname: Starkman
authors.forename: Jazmin
authors.initials: J
authors.lastname: De Anda
authors.forename: Julian
authors.initials: J
authors.lastname: Arista-Nasr
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Valdovinos-Diaz