title: Role of ArfGAP1 in COPI vesicle biogenesis.
abstract: Studies from our group suggest that ArfGAP1 acts not only as an Arf regulator but also as an Arf effector, with both roles promoting COPI vesicle formation. However, others have concluded differently, specifically that ArfGAP1 only acts as an Arf regulator, which involves inhibition of COPI vesicle formation by preventing components of the COPI complex from binding to target membrane. Here, we propose plausible reconciling explanations for this apparent contradiction.
authors.affiliation: Brigham and Women's Hospital; Harvard Medical School; Boston, MA USA.
authors.forename: Victor W
authors.initials: VW
authors.lastname: Hsu