title: Perfusion computed tomography findings of autoimmune pancreatitis.
abstract: OBJECTIVE
  The aim of this study was to clarify the pancreatic blood perfusion in patients with autoimmune pancreatitis (AIP) and the changes after steroid treatment.
  
  
  METHODS
  Perfusion computed tomography was performed in 11 patients with AIP and 12 control subjects. Pancreatic volumetric blood flow (F(V)), volume of distribution (V(D)), and blood transit time τ were determined from a single-compartment kinetic model. Nine patients with AIP were reexamined by perfusion computed tomography after corticosteroid administration.
  
  
  RESULTS
  The pancreatic F(V) values of the 11 patients with AIP (82.7/min) were significantly lower than those of control subjects (163.5/min, P = 0.0006). On the other hand, the pancreatic V(D) and τ values were not significantly different between AIP and normal. After steroid treatment, the F(V) values of 9 reexamined patients with AIP (76.2/min) were significantly elevated (109.8/min, P = 0.0391). However, the changes of the values after the treatment differed in degree among individuals. The values of 4 patients were dramatically elevated to greater than 100/min, whereas those of 4 other patients did not improve well. The value of the remaining patient whose initial F(V) value was normal (168.09/min) did not change after the treatment.
  
  
  CONCLUSIONS
  Pancreatic volumetric perfusion was attenuated in AIP patients. The perfusion was improved after the steroid treatment.
authors.affiliation: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai City, Miyagi, Japan. morihirota@med.tohoku.ac.jp
authors.forename: Morihisa
authors.initials: M
authors.lastname: Hirota
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kanno
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kikuta
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kume
authors.forename: Shin
authors.initials: S
authors.lastname: Hamada
authors.forename: Jun
authors.initials: J
authors.lastname: Unno
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Ito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ariga
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Chiba
authors.forename: Atsushi
authors.initials: A
authors.lastname: Masamune
authors.forename: Kennichi
authors.initials: K
authors.lastname: Satoh
authors.forename: Tooru
authors.initials: T
authors.lastname: Shimosegawa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000097:blood / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D010195:Pancreatitis / Q000097:blood / Q000000981:diagnostic imaging* / Q000188:drug therapy; D012039:Regional Blood Flow / Q000187:drug effects; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G