title: [Risk factors for premature coronary disease in women].
abstract: BACKGROUND
  Coronary disease is the leading cause of death in women, and consequently, identification of cardiovascular risk factors must be a priority. Recent studies have linked pregnancy disturbances and coronary disease, but this hypothesis has remained unproved in Hispanic women.
  
  
  OBJECTIVE
  The association of traditional risk factors and pregnancy disturbances with coronary heart disease was assessed in a sample of women with premature coronary disease.
  
  
  METHODS
  The case control study included only women <55 years old, who had undergone a coronary angiography. Two hundred women were included, 100 without and 100 with coronary disease, and with mean ages of 46.5±4.3 and 49.5±3.7 years, respectively. Logistic regression analysis was used to assess the relationship between risk factors and coronary disease. Crude and multivariate adjusted odds ratios with 95% confidence intervals were calculated.
  
  
  RESULTS
  Univariate analysis showed an association between coronary disease and the past medical history of preeclampsia, premature delivery, low birth weight, diabetes, hypercholesterolemia and smoking habit. Logistic regression analysis showed an association of premature delivery (OR=6.0, 95%CI 2.3-15.0, p<0.01), hypercholesterolemia (OR=4.1, 95%CI 2.1-7.8, p<0.01) and smoking habit (OR=1.7, 95%Ci 0.9-3.2, p=0.08). The practice of regular physical activity was identified as a protection factor (OR=0.5, 95%CI 0.3-1.0, p=0.04).
  
  
  CONCLUSIONS
  Pregnancy disturbances and traditional risk factors were related to an increased risk of coronary artery disease in a Hispanic population of women with premature coronary disease.
authors.affiliation: Unidad de Cuidados Coronarios, Clínica Cardiovascular Santa María, Medellín, Colombia. clarais@une.net.co
authors.forename: Clara Inés
authors.initials: CI
authors.lastname: Saldarriaga
authors.forename: Gloria
authors.initials: G
authors.lastname: Franco
authors.forename: Ana María
authors.initials: AM
authors.lastname: Garzón
authors.forename: Isabel
authors.initials: I
authors.lastname: García
authors.forename: Nataly
authors.initials: N
authors.lastname: Mejía
authors.forename: Astrid
authors.initials: A
authors.lastname: Restrepo
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D017023:Coronary Angiography; D003327:Coronary Disease / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors