title: Beneficial effects of anisodamine in shock involved cholinergic anti-inflammatory pathway.
abstract: Anisodamine, an antagonist of muscarinic receptor, has been used therapeutically to improve blood flow in circulatory disorders such as septic shock in China since 1965. The main mechanism of anisodamine for anti-shock proposed in Pharmacology for Chinese medical students is to improve blood flow in the microcirculation. Here, we suggest a new mechanism for its anti-shock effect. That is, anisodamine, by blocking muscarinic receptor, results in rerouting of acetylcholine to α7 nicotinic acetylcholine receptor (α7nAChR) bringing about increased acetylcholine-mediated activation of α7nAChR and the cholinergic anti-inflammatory pathway.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University Shanghai, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.forename: Dong-Jie
authors.initials: DJ
authors.lastname: Li
authors.forename: Chong
authors.initials: C
authors.lastname: Liu
authors.forename: Ding-Feng
authors.initials: DF
authors.lastname: Su
authors.forename: Fu-Ming
authors.initials: FM
authors.lastname: Shen