title: [Pathogenic mechanism of NSAIDs-induced mucosal injury in lower gastrointestinal tract].
abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for musculoskeletal pain and inflammation. Because low-dose aspirins reduce the risk of coronary and cerebrovascular events, consumption of them are rising worldwide. However, NSAIDs induce ulcers and bleeding not only in upper gastrointestinal tract but also in the small and large intestine. The recent advanced modalities such as double balloon endoscopy and video-capsule endoscopy enable the detection of NSAIDs-induced mucosal injury in the small intestine accurately. Topical direct injury of NSAIDs and cyclooxygenase (COX) inhabitation resulting in prostaglandin (PG) suppression are two main pathogenic mechanisms of lower gastrointestinal damage. Further analysis for the mechanism of effect and side effect of NSAIDs are warranted to develop the therapeutic and prevention method of NSAIDs-induced lower gastrointestinal mucosal injury.
authors.affiliation: Department of Gastroenterology, Juntendo University School of Medicine.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Beppu
authors.forename: Taro
authors.initials: T
authors.lastname: Osada
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Shibuya
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced*; D007413:Intestinal Mucosa / Q000187:drug effects; D007420:Intestine, Large
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal