title: Reconstruction of fully three-dimensional high spatial and temporal resolution MR temperature maps for retrospective applications.
abstract: Many areas of MR-guided thermal therapy research would benefit from temperature maps with high spatial and temporal resolution that cover a large three-dimensional volume. This article describes an approach to achieve these goals, which is suitable for research applications where retrospective reconstruction of the temperature maps is acceptable. The method acquires undersampled data from a modified three-dimensional segmented echo-planar imaging sequence and creates images using a temporally constrained reconstruction algorithm. The three-dimensional images can be zero-filled to arbitrarily small voxel spacing in all directions and then converted into temperature maps using the standard proton resonance frequency shift technique. During high intensity focused ultrasound heating experiments, the proposed method was used to obtain temperature maps with 1.5 mm × 1.5 mm × 3.0 mm resolution, 288 mm × 162 mm × 78 mm field of view, and 1.7 s temporal resolution. The approach is validated to demonstrate that it can accurately capture the spatial characteristics and time dynamics of rapidly changing high intensity focused ultrasound-induced temperature distributions. Example applications from MR-guided high intensity focused ultrasound research are shown to demonstrate the benefits of the large coverage fully three-dimensional temperature maps, including characterization of volumetric heating trajectories and near- and far-field heating.
authors.affiliation: Department of Radiology, University of Utah, Salt Lake City, Utah 84108, USA. nicktodd99@yahoo.com
authors.forename: Nick
authors.initials: N
authors.lastname: Todd
authors.forename: Urvi
authors.initials: U
authors.lastname: Vyas
authors.forename: Josh
authors.initials: J
authors.lastname: de Bever
authors.forename: Allison
authors.initials: A
authors.lastname: Payne
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Parker
mesh_terms: D000465:Algorithms; D001931:Brain Mapping / Q000379:methods*; D017352:Echo-Planar Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012189:Retrospective Studies; D059629:Signal-To-Noise Ratio; D013817:Thermography / Q000379:methods*