title: [Early surgical outcomes of coronary heart disease with severe ischemic mitral regurgitation].
abstract: OBJECTIVE
  To summarize the experience with surgical treatment of coronary artery disease with severe ischemic mitral valve regurgitation (IMR).
  
  
  METHODS
  From January 2006 to December 2009, 45 patients (35 males, 10 females aged 32-74 years) with the diagnosis of coronary artery disease complicated by IMR underwent coronary artery bypass grafting (CABG) combined with mitral valve plasty (MVP, 24 cases) or mitral valve replacement (MVR, 21 cases).
  
  
  RESULTS
  Perioperative deaths occurred in 2 cases due to multiple organ failure (MOF). Echocardiography showed a significant reduction of the mitral regurgitation area (from 11.80∓2.45 cm(2) to 2.83∓0.98 cm(2), t=22.80, P=0.00) after CABG combined with mitral valve surgery, with also significantly reduced postoperative left ventricular end diastolic diameter (LVEDD) (from 57.61∓10.06 mm to 51.84∓8.98 mm, t=2.85, P=0.005). No significant difference was detected in the left ventricular ejection fraction after the operation [(52.7∓15.4)% vs (53.2∓13.2)%, t=0.16, P=0.87)].
  
  
  CONCLUSIONS
  CABG combined with mitral valve surgery can improve early postoperative left ventricular function in patients with ischemic coronary heart disease complicated by severe mitral regurgitation, but further follow-up study is still needed for evaluation of the long-term results.
authors.affiliation: Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou 510080, China.
authors.forename: Ming-jie
authors.initials: MJ
authors.lastname: Mai
authors.forename: Xing-quan
authors.initials: XQ
authors.lastname: Chen
authors.forename: Shao-yi
authors.initials: SY
authors.lastname: Zheng
authors.forename: Ruo-bin
authors.initials: RB
authors.lastname: Wu
authors.forename: Hui-ming
authors.initials: HM
authors.lastname: Guo
authors.forename: Jin-song
authors.initials: JS
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000601:surgery*; D017202:Myocardial Ischemia / Q000150:complications / Q000601:surgery*; D016896:Treatment Outcome