title: A novel pseudo-complementary PNA G-C base pair.
abstract: Pseudo-complementary oligonucleotide analogues and mimics provide novel opportunities for targeting duplex structures in RNA and DNA. Previously, a pseudo-complementary A-T base pair has been introduced. Towards sequence unrestricted targeting, a pseudo-complementary G-C base pair consisting of the unnatural nucleobases n6-methoxy-2,6-diaminopurine (previously described in a DNA context) and N4-benzoylcytosine is now presented for design of pseudo-complementary PNA oligomers (pcPNAs).
authors.affiliation: Department of Cellular and Molecular Medicine; Faculty of Health Sciences; The Panum Institute; University of Copenhagen; Copenhagen, Denmark.
authors.forename: Anne G
authors.initials: AG
authors.lastname: Olsen
authors.forename: Otto
authors.initials: O
authors.lastname: Dahl
authors.forename: Asger B
authors.initials: AB
authors.lastname: Petersen
authors.forename: John
authors.initials: J
authors.lastname: Nielsen
authors.forename: Peter E
authors.initials: PE
authors.lastname: Nielsen