title: Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection.
abstract: Lysophospholipids may play an important protective role during primary infection of Mycobacterium tuberculosis (MTB) by enhancing innate antimycobacterial immune response of both macrophages and alveolar epithelial cells. Here, we show that treatment with lysophosphatidic acid (LPA) of mice aerogenically infected with MTB immediately after infection results in a significant early reduction of pulmonary CFUs and of histopathological damage in comparison with control mice. In contrast, treatment of acute disease does not result in any improvement of both microbiological and histopathological parameters. Altogether, these results show that LPA treatment can exert protective effect if administrated during primary infection, only.
authors.affiliation: Institute of Microbiology, Catholic University of the Sacred Heart, 00168 Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Delogu
authors.forename: Michela
authors.initials: M
authors.lastname: Sali
authors.forename: Stefano
authors.initials: S
authors.lastname: Rocca
authors.forename: Gianluca
authors.initials: G
authors.lastname: Quintiliani
authors.forename: Marilina B
authors.initials: MB
authors.lastname: Santucci
authors.forename: Emanuela
authors.initials: E
authors.lastname: Greco
authors.forename: Andrea
authors.initials: A
authors.lastname: Cabibbo
authors.forename: Francesca
authors.initials: F
authors.lastname: Mariani
authors.forename: Vittorio
authors.initials: V
authors.lastname: Colizzi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fadda
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fraziano
mesh_terms: D000208:Acute Disease; D000818:Animals; D015169:Colony Count, Microbial; D005260:Female; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology; D008246:Lysophospholipids / Q000276:immunology / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D013110:Sphingosine / Q000031:analogs & derivatives / Q000276:immunology / Q000494:pharmacology; D013997:Time Factors; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine; C032881:lysophosphatidic acid