title: Type V collagen genotype and exercise-related phenotype relationships: a novel hypothesis.
abstract: We have shown that a variant within COL5A1, which encodes a subunit of type V collagen, is associated with injury and performance phenotypes. Although seemingly unrelated, these phenotypes are associated directly or indirectly with the mechanical properties of musculoskeletal soft tissue. We therefore hypothesize that variants in the COL5A1 gene alter fibril architecture and structure and, thereby, mechanical properties.
authors.affiliation: UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town and the South African Medical Research Council, Newlands 7925, South Africa. malcolm.collins@uct.ac.za
authors.forename: Malcolm
authors.initials: M
authors.lastname: Collins
authors.forename: Michael
authors.initials: M
authors.lastname: Posthumus
mesh_terms: D020413:3' Untranslated Regions; D001265:Athletic Injuries / Q000235:genetics*; D024062:Collagen Type V / Q000235:genetics*; D015444:Exercise; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology*; D010641:Phenotype
chemical_list: D020413:3' Untranslated Regions; C530725:COL5A1 protein, human; D024062:Collagen Type V