title: Modulation of plant HMG-CoA reductase by protein phosphatase 2A: positive and negative control at a key node of metabolism.
abstract: The enzyme HMG-CoA reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis, critical not only for normal plant development, but also for the adaptation to demanding environmental conditions. Consistent with this notion, plant HMGR is modulated by many diverse endogenous signals and external stimuli. Protein phosphatase 2A (PP2A) is involved in auxin, abscisic acid, ethylene and brassinosteroid signaling and now emerges as a positive and negative multilevel regulator of plant HMGR, both during normal growth and in response to a variety of stress conditions. The interaction with HMGR is mediated by B" regulatory subunits of PP2A, which are also calcium binding proteins. The new discoveries uncover the potential of PP2A to integrate developmental and calcium-mediated environmental signals in the control of plant HMGR.
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Antolín-Llovera
authors.forename: Pablo
authors.initials: P
authors.lastname: Leivar
authors.forename: Montserrat
authors.initials: M
authors.lastname: Arró
authors.forename: Albert
authors.initials: A
authors.lastname: Ferrer
authors.forename: Albert
authors.initials: A
authors.lastname: Boronat
authors.forename: Narciso
authors.initials: N
authors.lastname: Campos
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D010940:Plant Proteins / Q000378:metabolism*; D010944:Plants / Q000201:enzymology*; D054648:Protein Phosphatase 2 / Q000378:metabolism*
chemical_list: D002135:Calcium-Binding Proteins; D010940:Plant Proteins; D006903:Hydroxymethylglutaryl CoA Reductases; D054648:Protein Phosphatase 2; D002118:Calcium