title: In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions.
abstract: Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim of this study was to define the in vitro pH-activity relationship. Finafloxacin exhibited optimal antibacterial activity between pH 5.0 and 6.0 at which MICs were 4- to 8-fold lower than those determined at neutral pH. These observations were then confirmed against a larger collection of bacteria. These data suggest that finafloxacin could potentially offer a therapeutic advantage within acidic foci of infection.
authors.affiliation: MerLion Pharmaceuticals GmbH, Robert-Rössle Strasse 10, Berlin, Germany. william.stubbings@basilea.com
authors.forename: Will
authors.initials: W
authors.lastname: Stubbings
authors.forename: Pamela
authors.initials: P
authors.lastname: Leow
authors.forename: Goh Chee
authors.initials: GC
authors.lastname: Yong
authors.forename: Falicia
authors.initials: F
authors.lastname: Goh
authors.forename: Barbara
authors.initials: B
authors.lastname: Körber-Irrgang
authors.forename: Michael
authors.initials: M
authors.lastname: Kresken
authors.forename: Rainer
authors.initials: R
authors.lastname: Endermann
authors.forename: Harald
authors.initials: H
authors.lastname: Labischinski
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D024841:Fluoroquinolones / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D015242:Ofloxacin; C560572:finafloxacin