title: PVC membrane sensor for potentiometric determination of iron (II) in some pharmaceutical formulations based on a new neutral ionophore.
abstract: A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relative wide ferrous concentration range (1 × 10(-3) to 6 × 10(-6) M), with cationic slope of 31.5 ± 0.5, mV per concentration decade over a pH range of 5.0-9.0. The direct determination of 0.25-56.0 µg/ml of ferrous in aqueous solution shows an average recovery of 98.5% and a mean relative standard deviation of 1.5% at 20.0 µg/ml. The sensor displays long life-span, long-term stability, high reproducibility, and short response time. Selectivity coefficients for Fe(II) relative to a number of interfering substances were investigated. The sensor shows high significantly for Fe(2+) over Fe,(3+) Cu,(2+) Zn,(2+) Cd,(2+) Hg,(2+) Pb,(2+) Ni,(2+) Co,(2+) Mn,(2+) Al,(3+) alkaline earth and alkali metal ions. The sensor is successfully applied for measurement of ferrous in drug formulations. The results obtained for the determination of ferrous using the proposed sensor are comparable favourably with those obtained using the spectrophotometric method. Copyright © 2010 John Wiley & Sons, Ltd.
authors.affiliation: Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: M A
authors.initials: MA
authors.lastname: Abounassif
authors.forename: M A
authors.initials: MA
authors.lastname: Al-Omar
authors.forename: A-G E
authors.initials: AG
authors.lastname: Amr
authors.forename: G A E
authors.initials: GA
authors.lastname: Mostafa
mesh_terms: D002138:Calibration; D002412:Cations / Q000737:chemistry; D003998:Dicarboxylic Acids / Q000737:chemistry; D005296:Ferrous Compounds / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D017736:Ion-Selective Electrodes; D007476:Ionophores / Q000138:chemical synthesis / Q000737:chemistry*; D008567:Membranes, Artificial; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010968:Plasticizers / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry*; D011199:Potentiometry / Q000379:methods; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry; D015203:Reproducibility of Results; D013607:Tablets / Q000737:chemistry
chemical_list: D002412:Cations; D003998:Dicarboxylic Acids; D005296:Ferrous Compounds; D007476:Ionophores; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D010968:Plasticizers; D011725:Pyridines; D013607:Tablets; C055481:dibutyl sebacate; D011143:Polyvinyl Chloride