title: Direct alkylation of indoles and amines by tert-enamides: facile access to pharmaceutically active 2-oxo-1-pyrrolidine analogues.
abstract: Direct alkylation of indoles and amines by tertiary enamides for the synthesis of pharmaceutically active 2-oxo-1-pyrrolidine analogues was described. With only a 0.5 mol% catalyst loading, molecular iodine was demonstrated to be efficiently enough to promote the reaction under neat condition. Only Markovnikov addition product was obtained indicating that the reactions proceeded with excellent regioselectivity.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Jiang
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Xu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Xu
authors.forename: Xue-Qiang
authors.initials: XQ
authors.lastname: Chu
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Ji
mesh_terms: D000478:Alkylation; D000577:Amides / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000588:Amines; D007211:Indoles; D004364:Pharmaceutical Preparations; D011759:Pyrrolidines