title: Microwave assisted synthesis of novel functionalized hydantoin derivatives and their conversion to 5-(Z) arylidene-4H-imidazoles.
abstract: 2-(Alkyl-1-yl)-1H-imidazol-5(4H)-ones 5a-n were synthesized via nucleophilic substitution of the methylsulfanyl group of the corresponding 2-(methylthio)-1H-imidazol-5(4H)-ones 3a-c with suitably substituted secondary amines. The starting 2-thioxo- imidazolidin-4-ones 2a,2b were prepared by condensation of thiohydantoin and benzo[b]-thiophene-3-carbaldehyde or benzofuran-3-carbaldehyde under microwave irracdiation (MW) conditions. 2-Methylthio derivatives 3a-c were prepared by treatment of 2a-b with methyl iodide in the presence of aqueous sodium hydroxide.
authors.affiliation: Department of Chemistry, Southern Methodist University, 3215 Daniel Avenue, Dallas, TX 75275, USA.
authors.forename: Sukanta
authors.initials: S
authors.lastname: Kamila
authors.forename: Haribabu
authors.initials: H
authors.lastname: Ankati
authors.forename: Edward R
authors.initials: ER
authors.lastname: Biehl
mesh_terms: D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D015394:Molecular Structure; D013867:Thiohydantoins / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D006827:Hydantoins; D007093:Imidazoles; D013867:Thiohydantoins; C029899:imidazole