title: Preexposure prophylaxis and timed intercourse for HIV-discordant couples willing to conceive a child.
abstract: Many HIV-discordant couples express a strong wish to conceive a child. Insemination with processed semen is offered to these couples in many countries. Given the very low level of transmission risk during fully suppressive antiretroviral therapy, we offered timed intercourse combined with preexposure prophylaxis to further reduce the transmission risk. In 53 cases, natural conception was attempted using the proposed method. Pregnancy rates were high and reached a plateau of 75% after six cycles. Advanced age in the female partner was a predictor for infertility in these couples.
authors.affiliation: Division of Infectious Diseases, Kantonsspital St Gallen, Switzerland. Pietro.Vernazza@kssg.ch
authors.forename: Pietro L
authors.initials: PL
authors.lastname: Vernazza
authors.forename: Irma
authors.initials: I
authors.lastname: Graf
authors.forename: Ulrike
authors.initials: U
authors.lastname: Sonnenberg-Schwan
authors.forename: Maria
authors.initials: M
authors.lastname: Geit
authors.forename: Anja
authors.initials: A
authors.lastname: Meurer
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D003075:Coitus; D005191:Family Characteristics; D005260:Female; D005306:Fertilization; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control* / Q000635:transmission; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D016742:Preconception Care / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011322:Primary Prevention; D012747:Sexual Partners
chemical_list: D019380:Anti-HIV Agents