title: Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation.
abstract: Factor for adipocyte differentiation 104 (fad104) is a regulator of adipogenesis and osteogenesis. Our previous study showed that fad104-deficient mice died immediately after birth, suggesting fad104 to be essential for neonatal survival. However, the cause of this rapid death is unclear. Here, we demonstrate the role of fad104 in neonatal survival. Phenotypic and morphological analyses showed that fad104-deficient mice died due to cyanosis-associated lung dysplasia including atelectasis. Furthermore, immunohistochemistry revealed that FAD104 was strongly expressed in ATII cells in the developing lung. Most importantly, the ATII cells in lungs were immature, and impaired the expression of surfactant-associated proteins. Collectively, these results indicate that fad104 has an indispensable role in lung maturation, especially the maturation and differentiation of ATII cells.
authors.affiliation: Department of Molecular Biology, Graduate School of Pharmaceutical Science, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi, Japan.
authors.forename: Keishi
authors.initials: K
authors.lastname: Kishimoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishizuka
authors.forename: Takashi
authors.initials: T
authors.lastname: Ueda
authors.forename: Kenji
authors.initials: K
authors.lastname: Kajita
authors.forename: Shinya
authors.initials: S
authors.lastname: Ugawa
authors.forename: Shoichi
authors.initials: S
authors.lastname: Shimada
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Osada
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Imagawa
mesh_terms: D050156:Adipogenesis; D000818:Animals; D002454:Cell Differentiation; D004622:Embryo, Mammalian / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism / Q000502:physiology*; D007150:Immunohistochemistry; D008168:Lung / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout
chemical_list: C538837:Fndc3b protein, mouse; D005353:Fibronectins