title: A Nature-Inspired Diels-Alder Reaction Facilitates Construction of the Bicyclo[2.2.2]octane Core of Andibenin B.
abstract: A rapid synthesis of the bicyclo[2.2.2]octane core of andibenin B via a nature-inspired intramolecular [4+2] cycloaddition is described. This cycloaddition permits the construction of a sterically congested bicycle and simultaneously establishes three new all-carbon quaternary stereogenic centers in a highly efficient fashion.
authors.affiliation: Frick Chemical Laboratory, Princeton University, Princeton, New Jersey 08544-1009.
authors.forename: Jillian E
authors.initials: JE
authors.lastname: Spangler
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Sorensen