title: Genomic, transcriptomic, and epigenomic approaches to recovery after acquired brain injury.
abstract: Genomics and its related fields have expanded rapidly, primarily because of the potential utility for clinical decision making and improving our understanding of the pathophysiology of complex conditions. The state of the science and technology associated with this field is such that current and future health care providers, when consulting with new patients about their acquired brain injury and options for rehabilitation, will use genetic information as a routine part of the process, which may include information received from a laboratory report that uses transcriptomic data, informs regarding patient prognosis, and makes recommendations for individualized therapeutic approaches to optimize recovery. This may sound like science fiction, but, in the field of oncology, it is the norm for breast cancer and, more recently, for colon cancer, with expansion to other types of cancer on the horizon as research data continue to contribute to the understanding of the pathophysiology of these conditions. Something similar for rehabilitation after acquired brain injury is much further off on the horizon. However, it is a possibility that will never be realized if the community of scientists and health care providers who work with these patients do not have the knowledge or expertise to embrace genomics and related approaches. This article discusses these approaches, some practical considerations for using such approaches, and what is currently published in this area with regard to brain injury.
authors.affiliation: Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA. yconley@pitt.edu
authors.forename: Yvette P
authors.initials: YP
authors.lastname: Conley
authors.forename: Sheila
authors.initials: S
authors.lastname: Alexander
mesh_terms: D001930:Brain Injuries / Q000453:epidemiology / Q000235:genetics / Q000534:rehabilitation; D057890:Epigenomics / Q000379:methods; D023281:Genomics / Q000379:methods*; D006801:Humans; D009017:Morbidity; D020127:Recovery of Function; D014481:United States / Q000453:epidemiology