title: Antibacterial dimeric copper(II) complexes with chromone-derived compounds.
abstract: A new series of six chromone-derived compounds and their Cu(II) complexes have been synthesized and characterized by their physical, spectral and analytical data. The ligands and their Cu(II) complexes were screened for their in vitro antibacterial activity against four Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri) and two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains by agar-well diffusion method. The ligands were found to exhibit either no or low-to-moderate activities against one or more bacterial species whereas, the Cu(II) complexes exhibited moderate-to-high activity. The ligands which were inactive before complexation became active upon complexation with the Cu(II) metal ion and less active became more active.
authors.affiliation: Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan. dr.zahidchohan@gmail.com
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
authors.forename: Mohammad S
authors.initials: MS
authors.lastname: Iqbal
authors.forename: Syed K
authors.initials: SK
authors.lastname: Aftab
authors.forename: A
authors.initials: A
authors.lastname: Rauf
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002867:Chromones / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D002867:Chromones; D009942:Organometallic Compounds; D003300:Copper