title: [Management and follow-up of antenatally diagnosed primary megaureters].
abstract: OBJECTIVE
  To study the diagnostic and outcome aspects of antenatally diagnosed primary megaureters and analyse the results of the postnatal medicochirurgical management.
  
  
  METHODS
  The authors report a retrospective analysis of 12 patients been born between 1998 and 2009 with primary megaureter antenatally diagnosed between 20 and 32weeks of gestation. A postnatal radiological assessment comprising urinary tract ultrasound, DTPA or MAG3 renal scintigraphy, retrograde cystography, DMSA renal scintigraphy and intravenous urography was performed. All the patients were put under urinary antiseptic treatment and followed since the birth.
  
  
  RESULTS
  This study comprised nine boys and three girls, all been born at term with normal trophicity. Mean age of antenatal diagnosis of hydronephrosis was 26weeks of gestation. Mean age of definitive postnatal diagnosis was ten months. Left megaureter was seen in five children, right in two cases and five patients had bilateral megaureter comprising a total of 17 renal units of which eight units were non-obstructed/non-refluxing, three units were refluxing, five units were obstructed and one unit was obstructed and refluxing. Megaureter was associated to controlateral ureteropelvic junction obstruction syndrome in one patient and to ipsilateral ureteral duplicity with a superior polar kidney in another case. Renal function was less than 20% in four renal units. The mean follow-up was four years (range : 10months to 11years). Outcome was marked by urinary infections in seven cases of which four patients had non-obstructed/non-refluxing megaureter. Six patients required surgical correction, two for non-obstructed/non-refluxing megaureter complicated with urinary recurring infections, three for obstructed megaureter with severe renal functional deterioration and one patient for bilateral refluxing megaureter grade V. Two other patients required surgical treatment, one for controlateral ureteropelvic junction obstruction syndrome and the other for ipsilateral ureteral duplicity with destroyed superior polar kidney. Mean age at surgery was 22,6months (range : 6 months to 7 years).
  
  
  CONCLUSIONS
  Half of our patients with antenatal diagnosis of primary megaureter required surgical correction. Urinary recurring infections, renal functional deterioration less than 20% and importance of ureteral dilatation with vesico-ureteric reflux grade V were predictive factors for surgery.
authors.affiliation: Service de pédiatrie, unité de néonatalogie, CHU Tahar-Sfar, Mahdia 5111, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Ghanmi
authors.forename: H
authors.initials: H
authors.lastname: Ben Hamouda
authors.forename: I
authors.initials: I
authors.lastname: Krichene
authors.forename: H
authors.initials: H
authors.lastname: Soua
authors.forename: A
authors.initials: A
authors.lastname: Ayadi
authors.forename: M M
authors.initials: MM
authors.lastname: Souissi
authors.forename: H
authors.initials: H
authors.lastname: Hamza
authors.forename: A
authors.initials: A
authors.lastname: Nouri
authors.forename: H
authors.initials: H
authors.lastname: Essabbeh
authors.forename: M T
authors.initials: MT
authors.lastname: Sfar
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006869:Hydronephrosis / Q000000981:diagnostic imaging* / Q000628:therapy; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal; D014515:Ureteral Diseases / Q000000981:diagnostic imaging* / Q000628:therapy