title: In vivo cancer imaging by poly(ethylene glycol)-b-poly(ɛ-caprolactone) micelles containing a near-infrared probe.
abstract: Noninvasive near-infrared (NIR) fluorescence imaging is a promising technique for the intraoperative assessment of solid tumor removal. We incorporated a lipophilic NIR probe, 1,1'-dioctadecyltetramethyl indotricarbocyanine iodide (DiR), in poly(ethylene glycol)-b-poly(ɛ-caprolactone) (PEG-b-PCL) micelles, resulting in DiR solubilization in water, occupying nanoscopic PEG-b-PCL micelles. DiR in a self-quenched or nonquenched state showed different kinetics of release from PEG-b-PCL micelles in vitro; however, both obtained high tumor delineation (tumor-to-muscle ratio of 30-43 from collected organs). These results suggest that PEG-b-PCL micelles with DiR are a promising nanosized imaging agent that will provide a basis for enhanced surgical guidance via NIR visualization of tumors.
  
  
  BACKGROUND
  In this paper, noninvasive near-infrared fluorescence imaging coupled with specific lipophilic probes is discussed as a promising technique for intraoperative assessment of solid tumor removal, leading to optimized outcomes for in toto removal of tumors.
authors.affiliation: Department of Pharmaceutical Science, School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, USA.
authors.forename: Hyunah
authors.initials: H
authors.lastname: Cho
authors.forename: Guilherme L
authors.initials: GL
authors.lastname: Indig
authors.forename: Jamey
authors.initials: J
authors.lastname: Weichert
authors.forename: Ho-Chul
authors.initials: HC
authors.lastname: Shin
authors.forename: Glen S
authors.initials: GS
authors.lastname: Kwon
mesh_terms: D002232:Carbocyanines / Q000737:chemistry*; D003952:Diagnostic Imaging / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008823:Micelles; D009369:Neoplasms / Q000175:diagnosis*; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D014867:Water
chemical_list: D002232:Carbocyanines; D005456:Fluorescent Dyes; D008823:Micelles; D011091:Polyesters; D014867:Water; C016240:polycaprolactone; D011092:Polyethylene Glycols; C024286:3,3'-dioctadecylindocarbocyanine