title: Chimeric Antigen Receptor Therapy for B-cell Malignancies.
abstract: We presented data showing that the CART-19 cells expressing the 4-1BB signaling domain can have unprecedented and massive in-vivo expansion, traffic to tumor sites, persist long term in vivo, and induce rapid and potent anti-tumor activity in chemotherapy refractory CLL patients.
authors.affiliation: 1. Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, 19104, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Porter
authors.forename: Michael
authors.initials: M
authors.lastname: Kalos
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zheng
authors.forename: Bruce
authors.initials: B
authors.lastname: Levine
authors.forename: Carl
authors.initials: C
authors.lastname: June