title: Adherence to breast and ovarian cancer screening recommendations for female relatives from the Ontario site of the Breast Cancer Family Registry.
abstract: This study compares adherence to breast and ovarian cancer screening recommendations among a population cohort of women at familial risk of breast and/or ovarian cancer. This cross-sectional study included 1039 first-degree female relatives without breast cancer identified from the Ontario site of the Breast Cancer Family Registry. We compared breast and ovarian cancer screening behaviors, using a telephone-administered questionnaire among three groups of women defined by their familial risk (high, moderate, and low) of breast and/or ovarian cancer. Associations between screening behaviors and familial risk were assessed using multinomial regression models adjusted by familial clustering. Women, 40-49 years of age, at moderate or high familial risk were significantly more likely to have had a screening mammogram within the past 12 months [odds ratio (OR): 2.80; 95% confidence interval (CI): 1.40-5.58], and women of less than 50 years of age were more likely to have a clinical breast examination (OR: 1.84; 95% CI: 1.02-3.31) compared with women at low familial risk. Compared with women at low or moderate familial risk, women at high familial risk were significantly more likely to have ever had a genetic test for the BRCA 1/2 genes (OR: 2.67; 95% CI: 1.76-4.05). Although the overall level of adherence among high-risk women is suboptimal in the community, women at a higher familial risk are adhering more often to cancer screening recommendations than women at a lower familial risk.
authors.affiliation: Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Campitelli
authors.forename: Anna M
authors.initials: AM
authors.lastname: Chiarelli
authors.forename: Lucia
authors.initials: L
authors.lastname: Mirea
authors.forename: Lindsay
authors.initials: L
authors.lastname: Stewart
authors.forename: Gord
authors.initials: G
authors.lastname: Glendon
authors.forename: Paul
authors.initials: P
authors.lastname: Ritvo
authors.forename: Irene L
authors.initials: IL
authors.lastname: Andrulis
authors.forename: Julia A
authors.initials: JA
authors.lastname: Knight
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer / Q000592:standards*; D005260:Female; D005820:Genetic Testing / Q000592:standards; D006801:Humans; D008327:Mammography / Q000592:standards; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D010349:Patient Compliance; D012042:Registries; D055815:Young Adult