title: [Characteristics of the intestinal dysbiosis and endotoxemia after hemicolectomy].
abstract: The normal intestinal microflora important for maintaining the optimum level of metabolic processes in the human body, the immune system, as well as to create a high colonization resistance against the pathogenic microbes. With aging, changes microbiocaenosis intestine, resulting in an increase in the total number of microbes in the gut and profound changes in the functional properties of microorganisms. Under physiological conditions, the main reservoir of endotoxin in the human body is the intestine. Endotoxins, penetrating through the intestinal mucosa, arrive first at the local (intestinal), and then through the portal system in the liver, are able to initiate it various lesions, including fatty degeneration of the parenchyma.
  
  
  OBJECTIVE
  Based on clinical and laboratory studies to determine changes in gut microbiota and the level of endotoxemia in elderly patients in the remote period after undergoing surgery--hemicolectomy.
  
  
  RESULTS
  Metabolic activity of microflora in the colon according to the concentrations of short chain fatty acids in the feces of elderly patients in distant periods after hemicolectomy revealed in various degrees of violation of the microbiota of the colon. Violation of gut microbiota leads to endotoxaemia, which has a toxic effect on liver function, level of endotoxin and protein that binds to endotoxin was significantly higher in patients who underwent left-sided hemicolectomy.
authors.forename: I A
authors.initials: IA
authors.lastname: Li
authors.forename: V N
authors.initials: VN
authors.lastname: Drozdov
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Sil'vestrova
authors.forename: G G
authors.initials: GG
authors.lastname: Varvanina
mesh_terms: D000368:Aged; D003082:Colectomy / Q000379:methods*; D003108:Colonic Diseases / Q000382:microbiology / Q000601:surgery; D019446:Endotoxemia / Q000097:blood / Q000209:etiology / Q000382:microbiology*; D004731:Endotoxins / Q000097:blood; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008565:Membrane Proteins / Q000097:blood; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology / Q000382:microbiology*
chemical_list: D004731:Endotoxins; D005232:Fatty Acids, Volatile; D008565:Membrane Proteins; C025357:endotoxin binding proteins