title: Evaluation of the HeartMate II™ left ventricular assist device in obese heart failure patients: effects on weight loss.
abstract: BACKGROUND
  The purpose of this study is to evaluate the effect on weight loss of the newer generation continuous flow HeartMate II™ left ventricular assist device (VAD) in obese heart failure (HF) patients.
  
  
  METHODS
  We retrospectively reviewed 3-year surgical data from a large heart transplant facility and identified obese patients with advanced heart failure who underwent successful implantation of either the HeartMate XVE(®) or the HeartMate II(®) VAD. For each patient weight and BMI at time of VAD implantation and at 6 months post-operatively were documented. Between group comparison was achieved with Student's T tests.
  
  
  RESULTS
  We identified 14 patients who had received the HeartMate XVE™ and 8 who had received the HeartMate II™. At 6 months, patients who received a HeartMate XVE™ demonstrated a significant reduction in mean body weight (249.6 ± 35.4lbs vs. 217.4 ± 20.5 lbs; P<0.05), while patients who received the HeartMate II™ demonstrated no significant change in weight (234.5 ± 41.7 lbs vs. 234.7 ± 43.0lbs; P=0.3).
  
  
  CONCLUSIONS
  The HeartMate XVE™ results in significant reductions in weight at 6 months in obese patients with heart failure while the HeartMate II does not. Further research is necessary to better understand the effects of VADs on weight loss in obese HF patients.
authors.affiliation: Cedars Sinai Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: Keith
authors.initials: K
authors.lastname: Thompson
authors.forename: Pavittarpaul
authors.initials: P
authors.lastname: Dhesi
authors.forename: David
authors.initials: D
authors.lastname: Nguyen
authors.forename: Lawrence
authors.initials: L
authors.lastname: Czer
authors.forename: Jamie
authors.initials: J
authors.lastname: Moriguchi
authors.forename: Ernst
authors.initials: E
authors.lastname: Schwarz
mesh_terms: D000328:Adult; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000601:surgery*; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome; D015431:Weight Loss