title: Prediction of torsade de pointes from the QT interval: analysis of a case series of amisulpride overdoses.
abstract: Electrocardiograms (ECGs) from a case series of 86 amisulpride overdose events in 66 patients were reviewed for abnormal QT intervals and torsade de pointes (TdP). Eight patients exhibited TdP. In this investigative case series, the magnitude of prolongation of the QT interval was a stronger predictor of TdP than the mere presence of a prolongation per se.
authors.affiliation: School of Pharmacy, University of Otago, Dunedin, New Zealand.
authors.forename: J P
authors.initials: JP
authors.lastname: Joy
authors.forename: C V
authors.initials: CV
authors.lastname: Coulter
authors.forename: S B
authors.initials: SB
authors.lastname: Duffull
authors.forename: G K
authors.initials: GK
authors.lastname: Isbister
mesh_terms: D000293:Adolescent; D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D013469:Sulpiride / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000506:poisoning; D016171:Torsades de Pointes / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride