title: Antimicrobial susceptibility testing of two Lawsonia intracellularis isolates associated with proliferative hemorrhagic enteropathy and porcine intestinal adenomatosis in South Korea.
abstract: This study represents the first published data on antimicrobial susceptibility of Asian isolates of Lawsonia intracellularis. We assessed MICs of 16 antimicrobials for two isolates of L. intracellularis recovered from diseased pigs in South Korea, one from a finisher pig with acute proliferative hemorrhagic enteropathy in 2002 and the other from a grower pig with porcine intestinal adenomatosis in 2010. Tylosin and tilmicosin were found to be the most active against L. intracellularis both intracellularly (MICs, 0.25 to 0.5 μg/ml and 0.125 μg/ml, respectively) and extracellularly (MICs, 0.25 to 0.5 μg/ml and 1 μg/ml, respectively).
authors.affiliation: Foreign Animal Disease Division, National Veterinary Research and Quarantine Service, Anyang-ro 175, Anyang-si 430-824, Republic of Korea. malvab2848@gmail.com
authors.forename: Jung-Yong
authors.initials: JY
authors.lastname: Yeh
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Lee
authors.forename: Hye-Ryun
authors.initials: HR
authors.lastname: Yeh
authors.forename: Aeran
authors.initials: A
authors.lastname: Kim
authors.forename: Ji Youn
authors.initials: JY
authors.lastname: Lee
authors.forename: Jeong-Min
authors.initials: JM
authors.lastname: Hwang
authors.forename: Bo-Kyu
authors.initials: BK
authors.lastname: Kang
authors.forename: Jong-Man
authors.initials: JM
authors.lastname: Kim
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Choi
authors.forename: Joong-Bok
authors.initials: JB
authors.lastname: Lee
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D045824:Desulfovibrionaceae Infections / Q000188:drug therapy* / Q000382:microbiology; D007422:Intestines / Q000382:microbiology*; D020639:Lawsonia Bacteria / Q000187:drug effects* / Q000472:pathogenicity*; D008826:Microbial Sensitivity Tests; D056910:Republic of Korea; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents