title: [Frailty: learnings from the SAFEs cohort study and future perspectives for the research].
abstract: Even though the efforts in research have detailed further the physiopathology and the dynamics of the frailty process an operational definition of frailty is still far from being unequivocal. Studies carried out from the SAFEs cohort study allowed a pragmatic approach in the identification of the at-risk groups for the lost of independency during the hospital stay and factors influencing their future at short-, mid- and long-term. Based upon these results, we propose to discuss the relevance of the current operational indicators of frailty in order to show that clinical markers or indicators are insufficient to differentiate the frailty process from normal ageing. Finally we give rise to the imperative necessity to detect frailty at a preclinical stage with the help of biological and more particularly inflammatory markers.
authors.affiliation: Département de médecine interne, réhabilitation et gériatrie, Hôpitaux Universitaires et faculté de médecine de Genève, Suisse. pierre.o.lang@hcuge.ch
authors.forename: Pierre-Olivier
authors.initials: PO
authors.lastname: Lang
authors.forename: Moustapha
authors.initials: M
authors.lastname: Dramé
authors.forename: Rachid
authors.initials: R
authors.lastname: Mahmoudi
authors.forename: Damien
authors.initials: D
authors.lastname: Jolly
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lanièce
authors.forename: Olivier
authors.initials: O
authors.lastname: Saint-Jean
authors.forename: Dominique
authors.initials: D
authors.lastname: Somme
authors.forename: Damien
authors.initials: D
authors.lastname: Heitz
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Gauvain
authors.forename: Thierry
authors.initials: T
authors.lastname: Voisin
authors.forename: Benoît
authors.initials: B
authors.lastname: de Wazières
authors.forename: Régis
authors.initials: R
authors.lastname: Gonthier
authors.forename: Claude
authors.initials: C
authors.lastname: Jeandel
authors.forename: Pascal
authors.initials: P
authors.lastname: Couturier
authors.forename: Joël
authors.initials: J
authors.lastname: Ankri
authors.forename: François
authors.initials: F
authors.lastname: Blanchard
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Novella
mesh_terms: D000203:Activities of Daily Living / Q000145:classification / Q000523:psychology; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005544:Forecasting; D016330:Frail Elderly / Q000523:psychology* / Q000706:statistics & numerical data; D006760:Hospitalization; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000175:diagnosis; D008297:Male; D012106:Research / Q000639:trends; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D015415:Biomarkers