title: Management of viral infections in solid organ transplant recipients.
abstract: Management of viral infections after transplantation involves antiviral drug therapy (if available) and reduction in immunosuppression, which allows for development of pathogen-specific immunity to the offending virus. Prevention of viral infections is of the utmost importance, and this may be accomplished through vaccination, antiviral strategies and infection control measures. This article discusses the current management of selected viral pathogens that cause clinical illness in solid organ transplant recipients. The benefits and toxicities of antiviral therapies are discussed in the context of prevention and treatment of various viral diseases. The emerging issue of antiviral resistance is emphasized for cytomegalovirus, recurrent hepatitis B and influenza, while the importance of immunominimization is discussed in the management of BK nephropathy and virus-associated malignancies.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, and the William J von Leibig Transplant Center, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. razonable.raymund@mayo.edu
authors.forename: Raymund R
authors.initials: RR
authors.lastname: Razonable
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D001739:BK Virus / Q000254:growth & development; D002986:Clinical Trials as Topic; D003587:Cytomegalovirus / Q000254:growth & development; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000628:therapy* / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000276:immunology / Q000628:therapy* / Q000821:virology; D006564:Herpesviridae / Q000254:growth & development; D006566:Herpesviridae Infections / Q000276:immunology / Q000628:therapy* / Q000821:virology; D006801:Humans; D007114:Immunization / Q000379:methods; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007251:Influenza, Human / Q000276:immunology / Q000628:therapy* / Q000821:virology; D016377:Organ Transplantation / Q000009:adverse effects*; D017918:Orthohepadnavirus / Q000254:growth & development; D009975:Orthomyxoviridae / Q000254:growth & development; D027601:Polyomavirus Infections / Q000276:immunology / Q000628:therapy* / Q000821:virology; D019737:Transplants
chemical_list: D000998:Antiviral Agents