title: Phytochemical analysis and in vitro antimicrobial and free-radical-scavenging activities of the essential oils from Euryops arabicus and Laggera decurrens.
abstract: The essential oils of the aerial part of two Asteraceae species, namely Euryops arabicus Steud. and Laggera decurrens (Vahl.) Hepper and Wood, were studied by GC and GC/MS. In parallel the antimicrobial and antioxidant activities were evaluated. The investigation led to the identification of 48 and 44 compounds for both plants, respectively. The essential oil of E. arabicus was rich in oxygenated sesquiterpenes (39.9%). The oil also contained a high content of sesquiterpene hydrocarbons (24.1%). Compounds such as caryophyllene oxide (8.6%), T-cadinol (7.0%), spathulenol (5.2%), (E)-β-caryophyllene (6.0%) and 2-epi-(E)-β-caryophyllene (6.0%) were the main constituents of the oil. Oxygenated monoterpenes also predominated in L. decurrens (46.3%). The thymoquinone-derivative, 3-methoxy-2-methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione (28.1%), thymol (5.7%) and eudesma-11-en-4a-ol (7.0%) were the most abundant constituents. Both essential oils showed antimicrobial activity with MIC-values between 0.13-5.25 mg/mL. Furthermore, only the essential oil of L. decurrens exhibited a strong antioxidant activity (91%) at 500 µg/mL.
authors.affiliation: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. r_mothana@ksu.edu.sa
authors.forename: Ramzi A
authors.initials: RA
authors.lastname: Mothana
authors.forename: Mansour S
authors.initials: MS
authors.lastname: Alsaid
authors.forename: Nawal M
authors.initials: NM
authors.lastname: Al-Musayeib
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects*; D016166:Free Radical Scavengers / Q000032:analysis / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D009822:Oils, Volatile / Q000032:analysis / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D016166:Free Radical Scavengers; D009822:Oils, Volatile