title: Cognitive impairment in acquired brain injury: a predictor of rehabilitation outcomes and an opportunity for novel interventions.
abstract: Cognitive impairment is a common sequela in acquired brain injury and one that predicts rehabilitation outcomes. There is emerging evidence that impairments in cognitive functions can be manipulated by both pharmacologic and nonpharmacologic interventions to improve rehabilitation outcomes. By using stroke as a model for acquired brain injury, we review the evidence that links cognitive impairment to poor rehabilitation outcomes and discuss possible mechanisms to explain this association. Furthermore, we examine nascent promising research that suggests that interventions that target cognitive impairments can lead to better rehabilitation outcomes.
authors.affiliation: Department of Psychiatry, School of Medicine, WPIC-BT 764, 3811 O'Hara St, Pittsburgh PA 15213, USA.
authors.forename: Ellen
authors.initials: E
authors.lastname: Whyte
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Skidmore
authors.forename: Howard
authors.initials: H
authors.lastname: Aizenstein
authors.forename: Joseph
authors.initials: J
authors.lastname: Ricker
authors.forename: Meryl
authors.initials: M
authors.lastname: Butters
mesh_terms: D001930:Brain Injuries / Q000150:complications / Q000453:epidemiology / Q000534:rehabilitation; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology / Q000534:rehabilitation; D018450:Disease Progression; D006801:Humans; D015994:Incidence; D015995:Prevalence; D020521:Stroke; D014481:United States