title: Genome sequence of Streptomyces sp. strain Tü6071.
abstract: Streptomyces sp. Tü6071 is a soil-dwelling bacterium which has a highly active isoprenoid biosynthesis. Isoprenoids are important precursors for biopharmaceutical molecules such as antibiotics or anticancer agents, e.g., landomycin. Streptomyces sp. Tü6071 produces the industrially important terpene glycosides phenalinolactones, which have antibacterial activity against several Gram-positive bacteria. The availability of the genome sequence of Streptomyces sp. Tü6071 allows for understanding the biosynthesis of these pharmaceutical molecules and will facilitate rational genome modification to improve industrial use.
authors.affiliation: Institute of Pharmaceutical Sciences, Pharmaceutical Bioinformatics, University of Freiburg, Hermann-Herder-Strasse 9, 79104 Freiburg, Germany.
authors.forename: Anika
authors.initials: A
authors.lastname: Erxleben
authors.forename: Julia
authors.initials: J
authors.lastname: Wunsch-Palasis
authors.forename: Björn A
authors.initials: BA
authors.lastname: Grüning
authors.forename: Marta
authors.initials: M
authors.lastname: Luzhetska
authors.forename: Andreas
authors.initials: A
authors.lastname: Bechthold
authors.forename: Stefan
authors.initials: S
authors.lastname: Günther
mesh_terms: D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D013302:Streptomyces / Q000145:classification* / Q000235:genetics*