title: Relationship between indocyanine green clearance test and feed intake and impaired hepatic function in dairy cows.
abstract: The purposes of this study were 1) to examine changes in the indocyanine green (ICG) clearance by feeding and 4-day fasting in dry cows, and (2) to investigate the relationship between ICG clearance and blood chemistry profile in postpartum cows. In 3 dry cows, post-feeding ICG half-life (T(1/2)) was shorter than the pre-feeding value, and post-fasting T(1/2) was longer than pre-feeding and post-feeding values. In 16 lactating cows, T(1/2) value at 2 weeks postpartum showed positive correlations with AST, T-Bil and γ-GTP. These results suggested that ICG clearance correlated with T-Bil and liver enzymes can be sensitive and accurate diagnostic marker for impaired liver function in dairy cows. In addition, ICG clearance is greatly affected by feeding and fasting.
authors.affiliation: Laboratory of Theriogenology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa 252–0880, Japan.
authors.forename: Mamiko
authors.initials: M
authors.lastname: Ono
authors.forename: Tadatoshi
authors.initials: T
authors.lastname: Ohtaki
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tanemura
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Ishii
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Tsumagari
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D004396:Coloring Agents / Q000493:pharmacokinetics*; D004435:Eating / Q000502:physiology*; D005260:Female; D005508:Food Deprivation / Q000502:physiology*; D006207:Half-Life; D048550:Hepatic Insufficiency / Q000097:blood / Q000175:diagnosis / Q000201:enzymology / Q000662:veterinary*; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008111:Liver Function Tests / Q000662:veterinary; D008657:Metabolic Clearance Rate; D049590:Postpartum Period; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D004396:Coloring Agents; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D007208:Indocyanine Green; D001663:Bilirubin