title: [N-terminal pro brain natriuretic peptide predicts hospitalization of hemodialysis patients for cardiovascular disease].
abstract: We investigated whether or not N-terminal pro brain natriuretic peptide (NT-proBNP) could predict hospitalization for cardiovascular disease (CVD) among Japanese hemodialysis patients. A total of 104 patients on maintenance dialysis 3 times per week were enrolled. We followed the patients for 23.9 +/- 4.2 months and 19 hospitalizations for CVD occurring during this period. The area under the curve (AUC) for the risk of CVD hospitalization was calculated after drawing a receiver operating characteristic curve. Predialysis NT-proBNP showed a larger AUC value than both postdialysis NT-proBNP and brain natriuretic peptide. The optimal cut-off value of predialysis NT-proBNP for predicting CVD hospitalization was 5,894 pg/mL, (sensitivity of 60 % and specificity of 76 %). Diabetes mellitus, a history of CVD, and the predialysis NT-proBNP level were significant determinants of CVD hospitalization according to Cox proportional hazards analysis. In conclusion, predialysis NT-proBNP is useful for predicting CVD hospitalization in hemodialysis patients.
authors.affiliation: Nephrology and Dialysis Division, Hiroshima Prefectural Hospital, Hiroshima, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Naito
authors.forename: Takao
authors.initials: T
authors.lastname: Masaki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Takahiko
authors.initials: T
authors.lastname: Ogawa
authors.forename: Mariko
authors.initials: M
authors.lastname: Ochiai
authors.forename: Naoki
authors.initials: N
authors.lastname: Hamaguchi
authors.forename: Shuma
authors.initials: S
authors.lastname: Hirashio
authors.forename: Toshiki
authors.initials: T
authors.lastname: Doi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yorioka
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D012372:ROC Curve; D006435:Renal Dialysis
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain