title: Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes?
abstract: One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. All these clinical situations could be the consequence of a progressive and persistent stem cell exhaustion syndrome (SCES). The main outcome of this SCES would be an irreversible loss of the effective regenerative mesenchymal stem cells (MSCs) pools. In this way, the normal repairing capacities of the organism could become inefficient. Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies.
authors.affiliation: Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, Argentina.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mansilla
authors.forename: Vanina
authors.initials: V
authors.lastname: Díaz Aquino
authors.forename: Daniel
authors.initials: D
authors.lastname: Zambón
authors.forename: Gustavo Horacio
authors.initials: GH
authors.lastname: Marin
authors.forename: Karina
authors.initials: K
authors.lastname: Mártire
authors.forename: Gustavo
authors.initials: G
authors.lastname: Roque
authors.forename: Thomas
authors.initials: T
authors.lastname: Ichim
authors.forename: Neil H
authors.initials: NH
authors.lastname: Riordan
authors.forename: Amit
authors.initials: A
authors.lastname: Patel
authors.forename: Flavio
authors.initials: F
authors.lastname: Sturla
authors.forename: Gustavo
authors.initials: G
authors.lastname: Larsen
authors.forename: Rubén
authors.initials: R
authors.lastname: Spretz
authors.forename: Luis
authors.initials: L
authors.lastname: Núñez
authors.forename: Carlos
authors.initials: C
authors.lastname: Soratti
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ibar
authors.forename: Michiel
authors.initials: M
authors.lastname: van Leeuwen
authors.forename: José María
authors.initials: JM
authors.lastname: Tau
authors.forename: Hugo
authors.initials: H
authors.lastname: Drago
authors.forename: Alberto
authors.initials: A
authors.lastname: Maceira