title: The dynamics of CD147 in Alzheimer's disease development and pathology.
abstract: CD147, also known as basigin, EMMPRIN, neurothelin, TCSF, M6, HT7, OX47, or gp42, is a transmembrane glycoprotein of the immunoglobulin super-family. It is expressed in many neuronal and non-neuronal tissues including the hippocampus, pre-frontal cortex thyroid, heart, early erythroid, amygdala, and placenta. This protein is involved in various cellular and biological functions, such as lymphocyte migration and maturation, tissue repair cancer progression, T and B lymphocyte activation, and induction of extracellular matrix metalloproteinase. The CD147 protein interacts with other proteins such as cyclophilin A (CyPA), Cyclophilin B (CyPB), sterol carrier protein (SCP), caveolin-1 and integrins, and can influence amyloid-β (Aβ) peptide levels, a protein that is central to Alzheimer's disease (AD) pathogenesis. Mechanisms by which CD147 regulate Aβ levels remain unclear, thus in this review we discuss its involvement in Aβ production and clearance and potential mechanisms by which controlling CD147 levels could impact on Aβ accumulation and AD pathogenesis.
authors.affiliation: Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
authors.forename: Limbikani J
authors.initials: LJ
authors.lastname: Kanyenda
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Verdile
authors.forename: Sherif
authors.initials: S
authors.lastname: Boulos
authors.forename: Sudarsan
authors.initials: S
authors.lastname: Krishnaswamy
authors.forename: Kevin
authors.initials: K
authors.lastname: Taddei
authors.forename: Bruno P
authors.initials: BP
authors.lastname: Meloni
authors.forename: Frank L
authors.initials: FL
authors.lastname: Mastaglia
authors.forename: Ralph N
authors.initials: RN
authors.lastname: Martins
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism; D000818:Animals; D051926:Basigin / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics; D002784:Cholesterol / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans
chemical_list: D016229:Amyloid beta-Peptides; D002352:Carrier Proteins; C072087:sterol carrier proteins; D051926:Basigin; D002784:Cholesterol; D053829:Amyloid Precursor Protein Secretases