title: NMR determination of free gallium(III) ions in aqueous solutions of Ga complexes, "cold" analogs of PET/SPECT tracers.
abstract: Ga complexes are widely used as radiopharmaceuticals for PET or SPECT imaging and as therapeutic agents. At physiological pH, free gallium(III) ions can stably exist as soluble gallate [Ga(OH)(4) ](-) , a nephrotoxic compound whose presence should be avoided. Any Ga complex, therefore, should be carefully checked for the absence of gallate before use. Here we show that (71) Ga NMR is a useful tool to rapidly detect the presence of gallate in aqueous solutions of Ga complexes and to follow the purification steps of the Ga complex solutions.
authors.affiliation: Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Belgium.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhou
authors.forename: C
authors.initials: C
authors.lastname: Henoumont
authors.forename: L
authors.initials: L
authors.lastname: Vander Elst
authors.forename: S
authors.initials: S
authors.lastname: Laurent
authors.forename: R N
authors.initials: RN
authors.lastname: Muller
mesh_terms: D005707:Gallic Acid / Q000032:analysis / Q000633:toxicity; D005710:Gallium Radioisotopes / Q000032:analysis / Q000633:toxicity*; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000032:analysis / Q000633:toxicity; D012996:Solutions; D015899:Tomography, Emission-Computed, Single-Photon; D014867:Water
chemical_list: D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D012996:Solutions; D014867:Water; D005707:Gallic Acid