title: Introduction to nanocoatings produced by layer-by-layer (LbL) self-assembly.
abstract: Studies on the adsorption of oppositely charged colloidal particles ultimately resulted in multilayered polyelectrolyte self-assembly. The inception of layer-by-layer constructed particles facilitated the production of multifunctional, stimuli-responsive carrier systems. An array of synthetic and natural polyelectrolytes, metal oxides and clay nanoparticles is available for the construction of multilayered nanocoats on a multitude of substrates or removable cores. Numerous substrates can be encapsulated utilizing this technique including dyes, enzymes, drugs and cells. Furthermore, the outer surface of the particles presents and ideal platform that can be functionalized with targeting molecules or catalysts. Some processing parameters determining the properties of these successive self-assembly constructs are the surface charge density, coating material concentration, rinsing and drying steps, temperature and ionic strength of the medium. Additionally, the simplicity of the layer-by-layer assembly technique and the availability of established characterization methods, render these constructs extremely versatile in applications of sensing, encapsulation and target- and trigger-responsive drug delivery.
authors.affiliation: School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705-2222, USA. mmdevilliers@pharmacy.wisc.edu
authors.forename: Melgardt M
authors.initials: MM
authors.lastname: de Villiers
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Otto
authors.forename: Schalk J
authors.initials: SJ
authors.lastname: Strydom
authors.forename: Yuri M
authors.initials: YM
authors.lastname: Lvov
mesh_terms: D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D057145:Nanoshells / Q000737:chemistry*