title: Wide-field imaging of fluorescent deoxy-glucose in ex vivo malignant and normal breast tissue.
abstract: Rapid in situ determination of surgical resection margins during breast cancer surgery would reduce patient time under anesthesia. We present preliminary data supporting the use of a fluorescent glucose analog (2-NBDG) as an optical contrast agent to differentiate freshly excised breast tissue containing cancerous cells from normal breast tissue. Multi-spectral images of 14 breast cancer specimens acquired before and after incubation with 2-NBDG demonstrated increased fluorescent signal in all of the malignant tissue due to increased 2-NBDG consumption. We demonstrate that 2-NBDG has potential as an optical contrast agent to differentiate cancerous from non-cancerous tissue.
authors.forename: R J
authors.initials: RJ
authors.lastname: Langsner
authors.forename: L P
authors.initials: LP
authors.lastname: Middleton
authors.forename: J
authors.initials: J
authors.lastname: Sun
authors.forename: F
authors.initials: F
authors.lastname: Meric-Bernstam
authors.forename: K K
authors.initials: KK
authors.lastname: Hunt
authors.forename: R A
authors.initials: RA
authors.lastname: Drezek
authors.forename: T K
authors.initials: TK
authors.lastname: Yu