title: Fetal gastroschisis: epidemiological characteristics and pregnancy outcomes in Mississippi.
abstract: We describe the epidemiological characteristics and identify maternal-fetal outcomes in pregnancies complicated by gastroschisis. We retrospectively reviewed 115 cases of gastroschisis at the University of Mississippi Medical Center. The incidence of gastroschisis trended upward between 2000 and 2008. Significant proportions of mothers were nonobese, nulliparous, teenagers, smokers, and nonconsumers of alcohol. Infants delivered at > 36 weeks or without sepsis had shorter hospital stay (HS) and interval to full enteral feeding (FEF). The rates of low birth weight (LBW), fetal growth restriction, and spontaneous preterm birth (PTB) were 63%, 45%, and 24%, respectively. Bowel atresia was noted in 9%. Rates of primary closure (25%), neonatal sepsis (29%), fetal death (2%), and infant mortality (4%) were notable. Median HS and interval to FEF were 40 and 30 days, respectively. The incidence of gastroschisis is increasing in Mississippi. Sepsis, LBW, and PTB are key determinants of poor infant outcomes.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA.
authors.forename: Kiran B
authors.initials: KB
authors.lastname: Tam Tam
authors.forename: Christian
authors.initials: C
authors.lastname: Briery
authors.forename: Alan D
authors.initials: AD
authors.lastname: Penman
authors.forename: Laura
authors.initials: L
authors.lastname: Bufkin
authors.forename: James A
authors.initials: JA
authors.lastname: Bofill
mesh_terms: D000328:Adult; D001724:Birth Weight; D003106:Colon / Q000002:abnormalities; D004750:Enteral Nutrition; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D020139:Gastroschisis / Q000453:epidemiology* / Q000401:mortality / Q000601:surgery; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007409:Intestinal Atresia / Q000453:epidemiology; D007902:Length of Stay; D008297:Male; D008922:Mississippi / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology; D055815:Young Adult