title: Microcomputed tomographic and histologic analysis of anorganic bone matrix coupled with cell-binding peptide suspended in sodium hyaluronate carrier after sinus augmentation: a clinical study.
abstract: OBJECTIVE
  Anorganic bovine hydroxyapatite matrix (ABM), when coupled with synthetic cell-binding peptide (P15), mimics the cell-binding region of type 1 collagen and is commercially available suspended in a sodium hyaluronate carrier. The aim of the present study, therefore, was to test the efficacy of ABM/P-15 Putty (DENTSPLY Friadent CeraMed) as a sole graft material for sinus augmentation in patients with severely resorbed posterior maxillae.
  
  
  METHODS
  Sinus augmentation was performed in 10 patients using ABM/P-15 Putty and two provisional dental implants (3.0 mm in diameter). The graft and implants were placed simultaneously with the aid of a surgical stent. After 8 or 16 weeks, the implants were removed using a 4.25-mm trephine bur; this was followed by immediate placement of wider-diameter (5.5-mm) implants. All 20 implants were scanned by microcomputed tomography to determine bone mineral density (BMD), percent bone volume (PBV), and percent bone contact (PBC).
  
  
  RESULTS
  There was a significant increase in the BMD of bone around the implants at 8 weeks and 16 weeks compared to native residual (control) bone. There was no significant difference in PBV or PBC between 8 weeks and 16 weeks. The average increase in bone height at 16 weeks was 9.63 ± 1 mm. Microcomputed tomographic images and histologic sections showed dense graft particles surrounded by vital trabecular bone.
  
  
  CONCLUSIONS
  BMD increases as early as 8 weeks and does not show an additional increase after 16 weeks. PepGen P-15 Putty was found to be a promising osteoconductive graft for sinus augmentation, supporting immediate placement of implants.
authors.affiliation: Georgia Health Sciences University, Augusta, USA.
authors.forename: Hany
authors.initials: H
authors.lastname: Emam
authors.forename: Galal
authors.initials: G
authors.lastname: Beheiri
authors.forename: Mohammed
authors.initials: M
authors.lastname: Elsalanty
authors.forename: Mohamed
authors.initials: M
authors.lastname: Sharawy
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000628:therapy*; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000187:drug effects*; D001862:Bone Resorption / Q000188:drug therapy / Q000601:surgery; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use; D003758:Dental Implantation, Endosseous / Q000379:methods; D004337:Drug Carriers / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D006882:Hydroxyapatites / Q000627:therapeutic use*; D008297:Male; D008437:Maxilla / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects / Q000601:surgery; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000601:surgery; D008875:Middle Aged; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods; D016348:Osseointegration / Q000187:drug effects; D010446:Peptide Fragments / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D055114:X-Ray Microtomography / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D004337:Drug Carriers; D004338:Drug Combinations; D005782:Gels; D006882:Hydroxyapatites; D010446:Peptide Fragments; C407062:cell-binding peptide P-15; D006820:Hyaluronic Acid; D003094:Collagen