title: Silylation-based kinetic resolution of monofunctional secondary alcohols.
abstract: The nucleophilic small molecule catalyst (-)-tetramisole was found to catalyze the kinetic resolution of monofunctional secondary alcohols via enantioselective silylation. Optimization of this new methodology allows for selectivity factors up to 25 utilizing commercially available reagents and mild reaction conditions.
authors.affiliation: Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, GSRC 109, Columbia, South Carolina 29208, USA.
authors.forename: Cody I
authors.initials: CI
authors.lastname: Sheppard
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Taylor
authors.forename: Sheryl L
authors.initials: SL
authors.lastname: Wiskur
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism; D013773:Tetramisole / Q000737:chemistry
chemical_list: D000438:Alcohols; D013773:Tetramisole