title: Selective ortho-bromination of substituted benzaldoximes using Pd-catalyzed C-H activation: application to the synthesis of substituted 2-bromobenzaldehydes.
abstract: Substituted 2-bromobenzaldehydes were synthesized from benzaldehydes using a three-step sequence involving a selective palladium-catalyzed ortho-bromination as the key step. O-Methyloxime serves as a directing group in this reaction. A rapid deprotection of substituted 2-bromobenzaldoximes afforded substituted 2-bromobenzaldehydes with good overall yields.
authors.affiliation: Centre d'Etudes et de Recherche sur le Médicament de Normandie, UPRES EA 4258, INC3M FR-CNRS 3038, UFR des Sciences Pharmaceutiques, Université de Caen Basse-Normandie, boulevard Becquerel, 14032 Caen cedex France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Dubost
authors.forename: Christine
authors.initials: C
authors.lastname: Fossey
authors.forename: Thomas
authors.initials: T
authors.lastname: Cailly
authors.forename: Sylvain
authors.initials: S
authors.lastname: Rault
authors.forename: Frederic
authors.initials: F
authors.lastname: Fabis
mesh_terms: D001547:Benzaldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D054879:Halogenation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D001547:Benzaldehydes; D010165:Palladium