title: IL-16 rs11556218 gene polymorphism is associated with coronary artery disease in the Chinese Han population.
abstract: OBJECTIVE
  Our aim was to investigate the association between IL-16 gene polymorphisms (rs4778889 C/T and rs11556218 G/T) and coronary artery disease (CAD).
  
  
  METHODS
  The initial cohort consisted of 300 CAD patients and 397 controls from the Chinese Han population. Genotyping was performed by using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). The positive association between polymorphism and CAD was replicated in another independent cohort, which included 424 CAD cases and 332 controls.
  
  
  RESULTS
  In the initial study, the allele and genotype frequencies of rs4778889 were not different between in CAD and controls (P>0.05). However, The G allele frequency of rs11556218 was significantly higher in the CAD cases than in the controls (CAD, 46.8% vs. controls, 22.8%, P<0.001). The risk of CAD was significantly higher in the G allele carriers than in the non-carriers (P<0.001, adjusted odds ratio = 7.27; 95% confidence interval, 4.13-12.8). In the replication cohort, G carriers of rs11556218 also had a higher risk of CAD (P = 0.005, adjusted OR = 2.33; 95% confidence interval, 1.45-3.74).
  
  
  CONCLUSIONS
  Our study suggested that IL-16 rs11556218 G/T polymorphism is significantly associated with the risk of CAD in the Chinese Han population.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, PR China.
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Public Management, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China.
authors.forename: Si
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Intensive Care Unit, the People Hospital of Sichuan province, Chengdu, Sichuan, PR China.
authors.forename: Lin-Ai
authors.initials: LA
authors.lastname: Pan
authors.affiliation: the Translational Medicine Research Lab, West China Secondary Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, PR China. Electronic address: zengzhi1954@hotmail.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zeng
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology / Q000208:ethnology; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D019410:Interleukin-16