title: A Ru(II) complex with 2-(4-(methylsulfonyl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline: synthesis, characterization, and acid-base and DNA-binding properties.
abstract: A new Ru(II) complex of [Ru(bpy)2(Hmspip)]Cl2 {in which bpy=2,2'-bipyridine, Hmspip=2-(4-(methylsulfonyl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline} have been synthesized and characterized. The ground- and excited-state acid-base properties of [Ru(bpy)2(Hmspip)]Cl2 and its parent complex of [Ru(bpy)2(Hpip)]Cl2 {Hpip=2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline} have been studied by UV-visible (UV-vis) and emission spectrophotometric pH titrations. [Ru(bpy)2(Hmspip)]Cl2 acts as a calf thymus DNA intercalators with a binding constant of 4.0×10(5) M(-1) in buffered 50 mM NaCl, as evidenced by UV-vis and luminescence titrations, steady-state emission quenching by [Fe(CN)6]4-, DNA competitive binding with ethidium bromide, reverse salt titrations and viscosity measurements.
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Wang
authors.forename: Cui-Li
authors.initials: CL
authors.lastname: Yuan
authors.forename: Hai-Shun
authors.initials: HS
authors.lastname: Jia
authors.forename: Ke-Zhi
authors.initials: KZ
authors.lastname: Wang
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair / Q000187:drug effects*; D004996:Ethidium / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007364:Intercalating Agents; D008163:Luminescent Measurements; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D010618:Phenanthrolines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007364:Intercalating Agents; D009942:Organometallic Compounds; D010618:Phenanthrolines; D012428:Ruthenium; D004247:DNA; C427203:calf thymus DNA; D004996:Ethidium