title: HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear.
abstract: HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat:P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature2010, 465, 747-751) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, 600 16 Street, San Francisco, CA 94158-2280.
authors.forename: Iván
authors.initials: I
authors.lastname: D'Orso
authors.forename: Alan D
authors.initials: AD
authors.lastname: Frankel