title: Cytomorphological changes in buccal mucosa of patients treated with low-level 1,064-nm laser radiation.
abstract: The aim of this study was to examine the cytomorphological changes occurring in the buccal mucosa in patients treated with low-level 1,064-nm laser radiation. Seventeen individuals (12 males, five females) 18-24 years of age were included in the study. Low-level 1,064-nm laser radiation was applied to the right buccal mucosa near the premolar region; this therapy was repeated for 10 days. Buccal epithelial cells were collected from the right and left premolar regions of the individuals with a brush before and after therapy. The specimens collected from the left side were measured cytomorphometrically and used for the control group. Student's t test was used for statistical comparison of the values of the buccal epithelial cells collected from individuals; a p value < 0.05 was considered statistically significant. None of the patients showed any adverse reactions to the low-level 1,064-nm laser radiation therapy during application. There was no cytogenetic damage to the therapied or non-therapied regions in the buccal mucosa cells, as determined cytomorphologically. The results suggest that low-level 1,064-nm laser radiation therapy has no genotoxic potential. Within the limitations of this study, it can be concluded that low-level 1,064-nm laser radiation therapy may be used safely in dental treatments.
authors.affiliation: Department of Periodontology, Gaziantep University Dentistry Faculty, Gaziantep, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Sezer
authors.forename: Mutan Hamdi
authors.initials: MH
authors.lastname: Aras
authors.forename: Ali Murat
authors.initials: AM
authors.lastname: Aktan
authors.forename: Beyhan
authors.initials: B
authors.lastname: Cengiz
authors.forename: Nadide
authors.initials: N
authors.lastname: Ozkul
authors.forename: Sinan
authors.initials: S
authors.lastname: Ay
mesh_terms: D000293:Adolescent; D001641:Bicuspid / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004847:Epithelial Cells / Q000528:radiation effects; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State; D028022:Low-Level Light Therapy / Q000295:instrumentation / Q000379:methods; D008297:Male; D009061:Mouth Mucosa / Q000166:cytology* / Q000528:radiation effects*; D055815:Young Adult