title: Prophylaxis of cytomegalovirus disease in mismatched patients after heart transplantation using combined antiviral and immunoglobulin therapy.
abstract: BACKGROUND
  Cytomegalovirus (CMV) is a common cause of infection and morbidity after heart transplantation. Seronegative recipients (R-) of seropositive donor hearts (D+) are at high risk for CMV disease. We compared three different CMV prophylaxis regimens using combined antiviral and immunoglobulin therapy.
  
  
  METHODS
  In 99 patients who survived more than 30 days after heart transplant, all received induction with antilymphocytic therapy and triple-drug therapy. In group A, D+R- patients received one dose of intravenous immunoglobulin (IVIG) followed by one dose of CMV-specific immunoglobulin (CMV-IVIG), and intravenous ganciclovir (GCV) for 4 weeks followed by 11 months of oral acyclovir (ACV). In group B, D+R- patients received one dose IVIG followed by five doses of CMV-IVIG and intravenous GCV for 14 weeks followed by 9 months of oral ACV. In group C, D+R- patients were treated with the same regimen as for group B, except oral ACV was replaced with oral GCV.
  
  
  RESULTS
  The actuarial freedom from CMV disease for D+R- patients at 1 month, 1 year, and 2 years after transplantation in group A was 100%, 25% ± 15%, and 25% ± 15%, respectively; group B was 100%, 67% ± 27%, and 67% ± 27%; group C was 100%, 83% ± 15%, and 83% ± 15% (P < .01, groups B and C vs group A). By comparison, the actuarial freedom from CMV disease for seropositive recipients (D-R+ or D+R+) at 1 month, 1 year, and 2 years in group A was 100%, 87% ± 7%, and 82% ± 8%, respectively; group B was 100%, 88% ± 8%, and 75% ± 11%; group C was 100%, 72% ± 9%, and 72% ± 9% (P = NS among groups). Rejection rates did not differ among the three groups.
  
  
  CONCLUSIONS
  A longer course of intravenous GCV with multiple doses of CMV-IVIG was a more effective prophylaxis regimen against CMV disease for the high-risk group of seronegative recipients of seropositive donor hearts.
authors.affiliation: Division of Cardiothoracic Surgery and Cardiology, Cedars-Sinai Heart Institute, Los Angeles, California 90048, USA.
authors.forename: L S C
authors.initials: LS
authors.lastname: Czer
authors.forename: A
authors.initials: A
authors.lastname: Ruzza
authors.forename: R
authors.initials: R
authors.lastname: Vespignani
authors.forename: M
authors.initials: M
authors.lastname: Rafiei
authors.forename: J R
authors.initials: JR
authors.lastname: Pixton
authors.forename: M
authors.initials: M
authors.lastname: Awad
authors.forename: M
authors.initials: M
authors.lastname: De Robertis
authors.forename: A V
authors.initials: AV
authors.lastname: Wong
authors.forename: A
authors.initials: A
authors.lastname: Trento
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D003586:Cytomegalovirus Infections / Q000517:prevention & control*; D006084:Graft Rejection; D016027:Heart Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*
chemical_list: D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous