title: Selectivity of pyramidal cells and interneurons in the human medial temporal lobe.
abstract: Neurons in the medial temporal lobe (MTL) respond selectively to pictures of specific individuals, objects, and places. However, the underlying mechanisms leading to such degree of stimulus selectivity are largely unknown. A necessary step to move forward in this direction involves the identification and characterization of the different neuron types present in MTL circuitry. We show that putative principal cells recorded in vivo from the human MTL are more selective than putative interneurons. Furthermore, we report that putative hippocampal pyramidal cells exhibit the highest degree of selectivity within the MTL, reflecting the hierarchical processing of visual information. We interpret these differences in selectivity as a plausible mechanism for generating sparse responses.
authors.affiliation: Department of Engineering, University of Leicester, Leicester,UK. mji3@le.ac.uk
authors.forename: Matias J
authors.initials: MJ
authors.lastname: Ison
authors.forename: Florian
authors.initials: F
authors.lastname: Mormann
authors.forename: Moran
authors.initials: M
authors.lastname: Cerf
authors.forename: Christof
authors.initials: C
authors.lastname: Koch
authors.forename: Itzhak
authors.initials: I
authors.lastname: Fried
authors.forename: Rodrigo Quian
authors.initials: RQ
authors.lastname: Quiroga
mesh_terms: D000200:Action Potentials; D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000503:physiopathology; D004567:Electrodes, Implanted; D018728:Entorhinal Cortex / Q000503:physiopathology; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020534:Parahippocampal Gyrus / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology*; D013702:Temporal Lobe / Q000503:physiopathology*; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult