title: Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation.
abstract: Neuroplastic changes, whether induced by traumatic brain injury (TBI) or therapeutic interventions, alter neurobehavioral outcome. Here we present several treatment strategies that have been evaluated by using experimental TBI models and discuss potential mechanisms of action (ie, plasticity) and how such changes affect function.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Alexandra N
authors.initials: AN
authors.lastname: Garcia
authors.forename: Mansi A
authors.initials: MA
authors.lastname: Shah
authors.forename: C Edward
authors.initials: CE
authors.lastname: Dixon
authors.forename: Amy K
authors.initials: AK
authors.lastname: Wagner
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Kline
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism / Q000503:physiopathology / Q000534:rehabilitation*; D004195:Disease Models, Animal; D009473:Neuronal Plasticity / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D026741:Physical Therapy Modalities; D020127:Recovery of Function
chemical_list: D018377:Neurotransmitter Agents