title: Effects of topical application of aqueous solutions of hexoses on epidermal permeability barrier recovery rate after barrier disruption.
abstract: Previous studies have suggested that hexose molecules influence the stability of phospholipid bilayers. Therefore, the effects of topical application of all 12 stereoisomers of dextro-hexose on the epidermal barrier recovery rate after barrier disruption were evaluated. Immediately after tape stripping, 0.1 m aqueous solution of each hexose was applied on hairless mouse skin. Among the eight dextro-aldohexoses, topical application of altose, idose, mannose and talose accelerated the barrier recovery, while allose, galactose, glucose and gulose had no effect. Among the four dextro-ketohexoses, psicose, fructose, sorbose and tagatose all accelerated the barrier recovery. As the effects of hexoses on the barrier recovery rate appeared within 1 h, the mechanism is unlikely to be genomic. Instead, these hexoses may influence phase transition of the lipid bilayers of lamellar bodies and cell membrane, a crucial step in epidermal permeability barrier homeostasis.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Denda
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004817:Epidermis / Q000187:drug effects* / Q000293:injuries / Q000502:physiology; D006601:Hexoses / Q000008:administration & dosage* / Q000737:chemistry; D008051:Lipid Bilayers / Q000378:metabolism; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D010539:Permeability / Q000187:drug effects; D012996:Solutions; D013237:Stereoisomerism
chemical_list: D006601:Hexoses; D008051:Lipid Bilayers; D012996:Solutions