title: Neuroregeneration in neurodegenerative disorders.
abstract: BACKGROUND
  Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration--implantation of viable cells as a therapeutical approach.
  
  
  CONCLUSIONS
  Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies.
  
  
  CONCLUSIONS
  In this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease.
authors.affiliation: Department of Cellular and Molecular Medicine, School of Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Enciu
authors.forename: Mihnea I
authors.initials: MI
authors.lastname: Nicolescu
authors.forename: Catalin G
authors.initials: CG
authors.lastname: Manole
authors.forename: Dafin F
authors.initials: DF
authors.lastname: Mureşanu
authors.forename: Laurenţiu M
authors.initials: LM
authors.lastname: Popescu
authors.forename: Bogdan O
authors.initials: BO
authors.lastname: Popescu
mesh_terms: D000544:Alzheimer Disease; D000818:Animals; D001921:Brain; D006801:Humans; D009416:Nerve Regeneration; D058953:Neural Stem Cells / Q000166:cytology; D055495:Neurogenesis; D010300:Parkinson Disease