title: Naphthylthiourea-modified permethylcyclodextrin as a highly sensitive and selective "turn-on" fluorescent chemosensor for Hg2+ in water and living cells.
abstract: A naphthylthiourea-modified cyclodextrin (1) and its urea derivative (2) were synthesized, and their fluorescence behaviors in the presence of various metal ions were investigated. Significantly, 1 showed a highly sensitive and selective fluorescence sensing ability for Hg(2+) over other metal ions in both water and living cells. That is, the addition of Hg(2+) to an aqueous solution of 1 gave a significantly enhanced fluorescence at ~380 nm. In contrast, the addition of other metal ions induced negligible fluorescence changes. The possible mechanism may be due to the transformation of thiourea to urea by Hg(2+)-induced desulfurization in water.
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhan-Hu
authors.initials: ZH
authors.lastname: Sun
authors.forename: Bao-E
authors.initials: BE
authors.lastname: Song
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D004396:Coloring Agents / Q000737:chemistry; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008628:Mercury / Q000032:analysis / Q000737:chemistry*; D015394:Molecular Structure; D012441:Saccharomyces cerevisiae / Q000737:chemistry*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D014508:Urea / Q000138:chemical synthesis / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D004396:Coloring Agents; D003505:Cyclodextrins; D005456:Fluorescent Dyes; D014867:Water; D014508:Urea; D008628:Mercury; D013890:Thiourea; C005277:alpha-naphthyl thiourea