title: Effects of age, gender and time on receptor expression and anti-Aspergillus functions of human phagocytes.
abstract: Phagocytes play a central role in immune defense. Their dysfunction predisposes to infections. This study determined the expression level of nine receptors involved in Aspergillus immune response as well as the values of phagocytosis and production of radical oxygen species after Aspergillus stimulation, in a healthy adult population. The expression values of the CD11b, CD11c, CD14, CD18, CD35, CD181, CD182, CD282 and CD284 receptors on peripheral human monocytes and granulocytes was established. A heterogenous expression of the CD282 on granulocytes was observed as CD181, CD182 and CD284 on monocytes. Similarly, we observed considerable variation in the expression of these receptors over time. Only CD282 on granulocytes varied with sex. No variation with age was observed. Adherence of Aspergillus conidia to phagocytes was dependent of individual, sex, age and time. A better characterization of these innate immunity parameters is necessary to develop in the future an immunologic surveillance strategy for transplant recipients.
authors.affiliation: Laboratoire Adaptation et Pathogénie des Micro-organismes, Université Joseph Fourier Grenoble, CNRS UMR 5163, Grenoble, France. Delphine.Aldebert@ujf-grenoble.fr
authors.forename: Delphine
authors.initials: D
authors.lastname: Aldebert
authors.forename: Magali
authors.initials: M
authors.lastname: Hypolite
authors.forename: Gaelle
authors.initials: G
authors.lastname: Bal
authors.forename: Chantal
authors.initials: C
authors.lastname: Dumestre-Pérard
authors.forename: Rose-Laurence
authors.initials: RL
authors.lastname: Bertini
authors.forename: Carole
authors.initials: C
authors.lastname: Rolland
authors.forename: Jean
authors.initials: J
authors.lastname: Boutonnat
authors.forename: Renée
authors.initials: R
authors.lastname: Grillot
authors.forename: Hervé
authors.initials: H
authors.lastname: Pelloux
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Brion
mesh_terms: D000328:Adult; D000367:Age Factors; D015703:Antigens, CD / Q000378:metabolism*; D000946:Antigens, Fungal / Q000008:administration & dosage; D001232:Aspergillus fumigatus / Q000276:immunology* / Q000472:pathogenicity; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D007157:Immunologic Surveillance; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010586:Phagocytes / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology*; D010587:Phagocytosis; D017382:Reactive Oxygen Species / Q000378:metabolism; D012727:Sex Characteristics; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D000946:Antigens, Fungal; D017382:Reactive Oxygen Species