title: Which one among the Pt-containing anticancer drugs more easily forms monoadducts with G and A DNA bases? A comparative study among oxaliplatin, nedaplatin, and carboplatin.
abstract: The platination processes of DNA bases with second- and third-generation Pt(II) anticancer drugs have been investigated using density functional theory (DFT) combined with the conductor-like dielectric continuum model (CPCM) approach, in order to describe their binding mechanisms and to obtain detailed data on the reaction energy profiles. Although there is no doubt that a Pt-N7 bond forms during initial attack, the energetic profiles for the formation of the monofunctional adducts are not known. Herein, a direct comparison between the rate of formation of the monofunctional adducts of the second- and third-generation anticancer drugs with guanine (G) and adenine (A) DNA bases has been made in order to spotlight possible common or different behavior. The guanine as target for platination process is confirmed to be preferred over adenine for all the investigated compounds and for both the hydrolyzed forms considered in our investigation. The preference for G purine base is dominated by electronic factors and promoted by a more favorable hydrogen-bonds pattern, confirming the important role played by H-bonds in determining both structural and kinetic control on the purine platination process.
authors.affiliation: Dipartimento di Chimica, Università della Calabria,Via P. Bucci, cubo 14c, 87036 Arca vacata di Rende (CS), Centro di Calcolo ad Alte Prestazioni per Elaborazioni Parallele e Distribuite-Centro d'Eccellenza MIUR, Italy. malberto@unical.it
authors.forename: Marta E
authors.initials: ME
authors.lastname: Alberto
authors.forename: Valeria
authors.initials: V
authors.lastname: Butera
authors.forename: Nino
authors.initials: N
authors.lastname: Russo
mesh_terms: D000225:Adenine / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000378:metabolism*; D016190:Carboplatin / Q000378:metabolism; D018736:DNA Adducts / Q000737:chemistry* / Q000378:metabolism*; D006147:Guanine / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D009944:Organoplatinum Compounds / Q000378:metabolism*; D000077150:Oxaliplatin; D011789:Quantum Theory; D013816:Thermodynamics
chemical_list: D000970:Antineoplastic Agents; D018736:DNA Adducts; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D006147:Guanine; C053989:nedaplatin; D016190:Carboplatin; D000225:Adenine