title: [A case of corpus callosum splenium encephalopathy and 2009 influenza A/H1N1].
abstract: Encephalopathy with reversible lesion of the corpus callosum splenium has a favorable prognosis, but that in 2009 influenza A/H1N1 is unknown. We report a case of clinically mild encephalopathy with a reversible lesion of the corpus callosum splenium in which 2009 influenza A/H1N1 virus was confirmed by laboratory tests. A 15-year-old Japanese girl seen at the emergency unit for loss of consciousness 18 hours after fever onset had been diagnosed with influenza A, and administered zanamivir. Diffusion-weighted magnetic resonance imaging (MRI) indicated lesions of the corpus callosum splenium, and electroencephalography showed slow basic activity, suggesting influenza A related to encephalopathy. She required intensive care with ventilation for two days. Her consciousness had become normal by day 6 after onset, and MRI findings improved on day 7. She recovered without adverse sequelae.
authors.affiliation: Department of Pediatrics, Tokyo Womens Medical University, Yachiyo Medical Center.
authors.forename: Sho
authors.initials: S
authors.lastname: Kimura
authors.forename: Chihiro
authors.initials: C
authors.lastname: Yoneda
authors.forename: Naotake
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Hamada
authors.forename: Masaru
authors.initials: M
authors.lastname: Terai
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000209:etiology*; D003337:Corpus Callosum; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications*