title: Three different causes of hypercalciuria.
abstract: Hypercalciuria is defined as urinary calcium excretion ≥0.1 mmol/kg/24 h, and can be a result of various disease states. The most frequent clinical signs of hypercalciuria include hematuria, abdominal pain, urolithiasis, nephrocalcinosis, dysuria, enuresis, and urinary tract infection. 3 case reports of children with hypercalciuria of different origin are presented, with final diagnoses of (1)idiopathic hypercalciuria, (2)familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), and (3)metabolic bone disease of prematurity, respectively. Assessment of hypercalciuria is essential in all children with urolithiasis and nephrocalcinosis, or demineralization of bone. It should be also a part of differential diagnostic procedure in hematuria, recurrent abdominal pain, urinary tract infection and enuresis in childhood.
authors.affiliation: Pediatrics, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.
authors.forename: S
authors.initials: S
authors.lastname: Skalova
authors.forename: M
authors.initials: M
authors.lastname: Konrad
authors.forename: S
authors.initials: S
authors.lastname: Kutilek
mesh_terms: D000483:Alleles; D001851:Bone Diseases, Metabolic / Q000175:diagnosis; D002118:Calcium / Q000652:urine; D002648:Child; D002675:Child, Preschool; D057167:Claudins / Q000235:genetics; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006580:Genetic Carrier Screening; D006801:Humans; D053565:Hypercalciuria / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis / Q000628:therapy; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000628:therapy; D007677:Kidney Function Tests; D008297:Male; D009397:Nephrocalcinosis / Q000175:diagnosis / Q000235:genetics; D010710:Phosphates / Q000008:administration & dosage / Q000097:blood; D015499:Renal Tubular Transport, Inborn Errors / Q000175:diagnosis / Q000235:genetics
chemical_list: D057167:Claudins; D010710:Phosphates; C502010:claudin 16; D002118:Calcium