title: Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives.
abstract: A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents.
authors.affiliation: Organic Chemistry Division-II, Indian Institute of Chemical Technology (CSIR), Tarnaka, Hyderabad 500607, India. lnagarapuiict@yahoo.com
authors.forename: Lingaiah
authors.initials: L
authors.lastname: Nagarapu
authors.forename: Jhansi
authors.initials: J
authors.lastname: Mateti
authors.forename: Hanmant K
authors.initials: HK
authors.lastname: Gaikwad
authors.forename: Rajashaker
authors.initials: R
authors.lastname: Bantu
authors.forename: M
authors.initials: M
authors.lastname: Sheeba Rani
authors.forename: N J
authors.initials: NJ
authors.lastname: Prameela Subhashini
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D011720:Pyrazoles / Q000737:chemistry*; D051381:Rats
chemical_list: D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; C031280:pyrazole; D002351:Carrageenan