title: ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy.
abstract: During pregnancy, severe maternal vitamin D deficiency has been associated with biochemical evidence of disordered skeletal homeostasis, congenital rickets, and fractures in the newborn. At this time, there is insufficient evidence to support a recommendation for screening all pregnant women for vitamin D deficiency. For pregnant women thought to be at increased risk of vitamin D deficiency, maternal serum 25-hydroxyvitamin D levels can be considered and should be interpreted in the context of the individual clinical circumstance. When vitamin D deficiency is identified during pregnancy, most experts agree that 1,000–2,000 international units per day of vitamin D is safe. Higher dose regimens used for treatment of vitamin D deficiency have not been studied during pregnancy. Recommendations concerning routine vitamin D supplementation during pregnancy beyond that contained in a prenatal vitamin should await the completion of ongoing randomized clinical trials.
mesh_terms: D000328:Adult; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000592:standards; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D014807:Vitamin D / Q000008:administration & dosage*; D014808:Vitamin D Deficiency / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D014807:Vitamin D