title: Carbon disulfide reagent allows the characterization of nonpolar analytes by atmospheric pressure chemical ionization mass spectrometry.
abstract: While atmospheric pressure ionization methodologies have revolutionized the mass spectrometric analysis of nonvolatile analytes, limitations native to the chemistry of these methodologies hinder or entirely inhibit the analysis of certain analytes, specifically, many nonpolar compounds. Examination of various analytes, including asphaltene and lignin model compounds as well as saturated hydrocarbons, demonstrates that atmospheric pressure chemical ionization (APCI) using CS(2) as the reagent produces an abundant and stable molecular ion (M(+•)) for all model compounds studied, with the exception of completely saturated aliphatic hydrocarbons and the two amino acids tested, arginine and phenylalanine. This reagent substantially broadens the applicability of mass spectrometry to nonvolatile nonpolar analytes and also facilitates the examination of radical cation chemistry by mass spectrometry.
authors.affiliation: Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Owen
authors.forename: Jinshan
authors.initials: J
authors.lastname: Gao
authors.forename: David J
authors.initials: DJ
authors.lastname: Borton
authors.forename: Lucas M
authors.initials: LM
authors.lastname: Amundson
authors.forename: Enada F
authors.initials: EF
authors.lastname: Archibold
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Tan
authors.forename: Khalid
authors.initials: K
authors.lastname: Azyat
authors.forename: Rik
authors.initials: R
authors.lastname: Tykwinski
authors.forename: Murray
authors.initials: M
authors.lastname: Gray
authors.forename: Hilkka I
authors.initials: HI
authors.lastname: Kenttämaa