title: A novel and potentially unifying mechanism for shock induced early coagulopathy.
authors.forename: John B
authors.initials: JB
authors.lastname: Holcomb
mesh_terms: D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004730:Endothelium, Vascular / Q000378:metabolism*; D005342:Fibrinolysis / Q000502:physiology*; D019276:Glycocalyx / Q000378:metabolism*; D017052:Hospital Mortality; D006801:Humans; D010343:Patient Admission; D011446:Prospective Studies; D011486:Protein C / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D053668:Syndecan-1 / Q000097:blood*; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D014947:Wounds and Injuries / Q000097:blood* / Q000401:mortality / Q000601:surgery*
chemical_list: D015415:Biomarkers; D011486:Protein C; C508241:SDC1 protein, human; D053668:Syndecan-1