title: Patients with early stage chronic lymphocytic leukemia: new risk stratification based on molecular profiling.
abstract: We investigated molecular and biological parameters reflecting the biology of chronic lymphocytic leukemia (CLL) that may help us to predict the time to first treatment (TTT). A group of 33 patients with newly diagnosed CLL (Binet stage A) were analyzed. We developed a new scoring system based on the serum levels of β(2)-microglobulin (β(2)M) and vascular endothelial growth factor (VEGF) and the expression of lipoprotein lipase (LPL). Patients with a score of 0 had a TTT of 58.4 months, while patients with a score of 3 (increased levels of β(2)M, LPL, and VEGF) had a significantly shorter TTT of only 10.6 months (p < 0.0001).
authors.affiliation: Clinic for Hematology, Clinical Center of Serbia, Belgrade, Serbia. tweety@scnet.rs
authors.forename: Darko
authors.initials: D
authors.lastname: Antic
authors.forename: Biljana
authors.initials: B
authors.lastname: Mihaljevic
authors.forename: Vladan
authors.initials: V
authors.lastname: Cokic
authors.forename: Marija Dencic
authors.initials: MD
authors.lastname: Fekete
authors.forename: Teodora Karan
authors.initials: TK
authors.lastname: Djurasevic
authors.forename: Sonja
authors.initials: S
authors.lastname: Pavlovic
authors.forename: Natasa
authors.initials: N
authors.lastname: Milic
authors.forename: Ivo
authors.initials: I
authors.lastname: Elezovic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D001613:beta 2-Microglobulin / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A; D001613:beta 2-Microglobulin; D008071:Lipoprotein Lipase