title: Post-transcriptional regulation of the Ras-ERK/MAPK signaling pathway.
abstract: The Ras-ERK/MAP (Mitogen-Activated Protein) kinase signaling pathway governs many cellular processes such as proliferation, differentiation, cell fate, homeostasis, and survival in all eukaryotes. Constitutive activation of the Ras-ERK/MAPK signaling pathway often leads to promotion of abnormal cell growth and tumorigenesis. Although the regulation of the Ras-ERK/MAPK signaling pathway by post-translational modification has been well elucidated, post-transcriptional regulations of this pathway are beginning to emerge in invertebrates and this work is extended to humans. In this review, we describe the conserved regulation of Ras-ERK/MAPK signaling by RNA-binding proteins (PUF, KH-domain, HuR, and LARP) and microRNAs (let-7 family miRNAs) and important implications for human diseases including cancers.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, USA.
authors.forename: Jarrett T
authors.initials: JT
authors.lastname: Whelan
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Hollis
authors.forename: Dong Seok
authors.initials: DS
authors.lastname: Cha
authors.forename: Adam S
authors.initials: AS
authors.lastname: Asch
authors.forename: Myon-Hee
authors.initials: MH
authors.lastname: Lee
mesh_terms: D048049:Extracellular Signal-Regulated MAP Kinases / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000235:genetics / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000096:biosynthesis / Q000235:genetics*; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*; D018631:ras Proteins / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D016601:RNA-Binding Proteins; D048049:Extracellular Signal-Regulated MAP Kinases; D020928:Mitogen-Activated Protein Kinases; D018631:ras Proteins