title: Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells.
abstract: The proinflammatory chemokine interleukin-8 is increased in asthmatic patients. Traditionally, ginger is used as an antiinflammatory drug. An extract and several compounds of Zingiber officinale (ginger) were tested in human bronchial epithelial cells (BEAS-2B cells) with respect to their effect on lipopolysaccharide (LPS)-induced secretion of the proinflammatory chemokine interleukin 8 (IL-8) and RANTES (regulated upon activation, normal T-cell expressed and secreted). An oily extract of ginger rhizome with > 25% total pungent compounds, ginger volatile oil, ar-curcumene and α-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and β-phellandrene showed no effect. The LPS-induced slight increase of RANTES was reduced by volatile oil, ar-curcumene and α-pinene. There was no effect of LPS on TNF-α. Our results suggest that distinct ginger compounds could be used as antiinflammatory drugs in respiratory infections.
authors.affiliation: Department of Pharmacology, Institute of Medicinal Chemistry, Münster University, Hittorfstr. 58-62, 48149 Münster, Germany.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Podlogar
authors.forename: Eugen J
authors.initials: EJ
authors.lastname: Verspohl
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000081008:Bicyclic Monoterpenes; D001980:Bronchi / Q000166:cytology* / Q000276:immunology; D002396:Catechols / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D018946:Chemokine CCL5 / Q000276:immunology; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes / Q000737:chemistry; D004306:Dose-Response Relationship, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D005233:Fatty Alcohols / Q000737:chemistry / Q000494:pharmacology; D020939:Zingiber officinale / Q000737:chemistry*; D006801:Humans; D016209:Interleukin-8 / Q000276:immunology / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology; D039821:Monoterpenes / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology; D055549:Volatile Organic Compounds / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000081008:Bicyclic Monoterpenes; C483024:CCL5 protein, human; D002396:Catechols; D018946:Chemokine CCL5; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D005233:Fatty Alcohols; D016209:Interleukin-8; D008070:Lipopolysaccharides; D039821:Monoterpenes; D010936:Plant Extracts; D010938:Plant Oils; D012717:Sesquiterpenes; D055549:Volatile Organic Compounds; C058582:beta-phellandrene; C086829:alpha-curcumene; C040115:shogaol; C007845:gingerol; C005451:alpha-pinene