title: A new type of monoterpenoid indole alkaloid precursor from Alstonia rostrata.
abstract: Currently, all monoterpenoid indole alkaloids (MIAs) have been derived from strictosidine, which originates from the condensation of tryptophan with secologanin in a 1:1 ratio. However, our phytochemical research on Alstonia rostrata revealed a potential new precursor for these compounds. We isolated the alstrostines A and B, and it was determined that they were derived from tryptophan and secologanin in a 1:2 ratio, which supported the presence of a new type of MIA precursor.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China. xhcai@mail.kib.ac.cn
authors.forename: Xiang-Hai
authors.initials: XH
authors.lastname: Cai
authors.forename: Mei-Fen
authors.initials: MF
authors.lastname: Bao
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Zeng
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Liu
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Luo
mesh_terms: D031051:Alstonia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D057888:Iridoid Glucosides / Q000737:chemistry; D015394:Molecular Structure; D046948:Secologanin Tryptamine Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014364:Tryptophan / Q000737:chemistry; D014748:Vinca Alkaloids / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D057888:Iridoid Glucosides; D046948:Secologanin Tryptamine Alkaloids; D014748:Vinca Alkaloids; C561512:alstrostine A; C561513:alstrostine B; C021086:secologanin; C021093:strictosidine; D014364:Tryptophan