title: Is Ankyrin a genetic risk factor for psychiatric phenotypes?
abstract: BACKGROUND
  Genome wide association studies reported two single nucleotide polymorphisms in ANK3 (rs9804190 and rs10994336) as independent genetic risk factors for bipolar disorder. Another SNP in ANK3 (rs10761482) was associated with schizophrenia in a large European sample. Within the debate on common susceptibility genes for schizophrenia and bipolar disorder, we tried to investigate common findings by analyzing association of ANK3 with schizophrenia, bipolar disorder and unipolar depression.
  
  
  METHODS
  We genotyped three single nucleotide polymorphisms (SNPs) in ANK3 (rs9804190, rs10994336, and rs10761482) in a case-control sample of German descent including 920 patients with schizophrenia, 400 with bipolar affective disorder, 220 patients with unipolar depression according to ICD 10 and 480 healthy controls. Sample was further differentiated according to Leonhard's classification featuring disease entities with specific combination of bipolar and psychotic syndromes.
  
  
  RESULTS
  We found no association of rs9804190 and rs10994336 with bipolar disorder, unipolar depression or schizophrenia. In contrast to previous findings rs10761482 was associated with bipolar disorder (p = 0.015) but not with schizophrenia or unipolar depression. We observed no association with disease entities according to Leonhard's classification.
  
  
  CONCLUSIONS
  Our results support a specific genetic contribution of ANK3 to bipolar disorder though we failed to replicate findings for schizophrenia. We cannot confirm ANK3 as a common risk factor for different diseases.
authors.affiliation: Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Josep Trueta s/n, Sant Cugat del Vallès-08195, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gella
authors.forename: Mònica
authors.initials: M
authors.lastname: Segura
authors.forename: Núria
authors.initials: N
authors.lastname: Durany
authors.forename: Bruno
authors.initials: B
authors.lastname: Pfuhlmann
authors.forename: Gerald
authors.initials: G
authors.lastname: Stöber
authors.forename: Micha
authors.initials: M
authors.lastname: Gawlik
mesh_terms: D000328:Adult; D017487:Ankyrins / Q000235:genetics*; D001714:Bipolar Disorder / Q000235:genetics*; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods / Q000706:statistics & numerical data*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C490613:ANK3 protein, human; D017487:Ankyrins