title: Additional prognostic factors in right colon cancer staging.
abstract: Based on the theory--which is now acknowledged-of a clinical difference between proximal and distal colon cancer and on the results of recent genetic and microbiological studies, a minority of authors have assumed that also in the sphere of right-sided colon cancer, tumors at three different locations, namely, the cecum and ascending and transverse colon, can be considered to be biologically different. These studies have provided the basis for a retrospective study carried out on 50 patients admitted to our department from 1996 to 2008 for tumor pathology of the right colon. The tumor was considered to be a unified biological entity and assessed in relation to the three above-mentioned locations. The results verify that the aggressive of the tumor increases from the cecum to the transverse, with a higher percentage of cecal tumors being in I stage, more tumors in the ascending colon being in II stage, and more transverse tumors, with the largest percentage of N+ and M+, in stages III and IV. This difference in biological behavior for the three tumor locations has been also found in terms of sensitiveness, both pre- and post-operation, of tumor markers CEA, TPA, and CA19-9. Clinical data revealed a binary relationship between the transverse, cecum, and ascending tumors, which ultimately affects patient mortality, which increases in a directly proportional way from the cecum to the transverse-in the case of a tumor at one of these locations.
authors.affiliation: Dipartimento di Scienze Anestesiologiche, Chirurgiche e dell'Emergenza, Seconda Università di Napoli, V.Aniello Falcone 290/A, 80100, Naples, Italy. d_parmeggiani@yahoo.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Parmeggiani
authors.forename: Nicola
authors.initials: N
authors.lastname: Avenia
authors.forename: Adelmo
authors.initials: A
authors.lastname: Gubitosi
authors.forename: Francesco
authors.initials: F
authors.lastname: Gilio
authors.forename: Pietro Francesco
authors.initials: PF
authors.lastname: Atelli
authors.forename: Massimo
authors.initials: M
authors.lastname: Agresti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D003110:Colonic Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor