title: Dynamic correction of artifacts due to susceptibility effects and time-varying eddy currents in diffusion tensor imaging.
abstract: In diffusion tensor imaging (DTI), spatial and temporal variations of the static magnetic field (B(0)) caused by susceptibility effects and time-varying eddy currents result in severe distortions, blurring, and misregistration artifacts, which in turn lead to errors in DTI metrics and in fiber tractography. Various correction methods have been proposed, but typically assume that the eddy current-induced magnetic field can be modeled as a constant or a single exponential decay within the DTI readout window. Here, we show that its temporal dependence is more complex because of the interaction of multiple eddy currents with different time constants, but that it remains very consistent over time. As such, we propose a novel dynamic B(0) mapping and off-resonance correction method that measures the exact spatial, temporal, and diffusion-weighting direction dependence of the susceptibility- and eddy current-induced magnetic fields to effectively and efficiently correct for artifacts caused by both susceptibility effects and time-varying eddy currents, thereby resulting in a high spatial fidelity and accuracy.
authors.affiliation: Brain Imaging and Analysis Center, Duke University, Durham, NC 27705, USA. trongkha.truong@duke.edu
authors.forename: Trong-Kha
authors.initials: TK
authors.lastname: Truong
authors.forename: Nan-kuei
authors.initials: NK
authors.lastname: Chen
authors.forename: Allen W
authors.initials: AW
authors.lastname: Song
mesh_terms: D016477:Artifacts; D001931:Brain Mapping / Q000379:methods*; D056324:Diffusion Tensor Imaging; D006801:Humans