title: Mattis Dementia Rating Scale 2: screening for MCI and dementia.
abstract: Identifying patients at higher risk of developing dementia is important. The usefulness of the Mattis Dementia Rating scale-Second Edition (MDRS-2) to detect and differentiate between patients with amnestic mild cognitive impairment (A-MCI), Parkinson's disease and MCI (PD-MCI), PD with dementia (PDD), and Alzheimer's disease (AD) was investigated. In all, 22 healthy controls (HC), 22 A-MCI, 22 PD-MCI, 16 PDD, and 22 AD patients were evaluated using an extensive neuropsychological battery, including the MDRS-2. The MDRS-2 total standardized score detected all groups of patients. The dementia groups performed worse than HC on the 5 MDRS-2 subscales. Alzheimer's disease patients scored higher than PDD on MDRS-2 conceptualization and lower on memory. Healthy controls were better than PD-MCI on MDRS-2 initiation/perseveration and memory and better than A-MCI on memory. No difference was found between the MCI groups. The MDRS-2 is a suitable short scale for MCI and dementia screening but is not specific enough to differentiate between A-MCI and PD-MCI.
authors.affiliation: École de psychologie, Université Laval and Centre de Recherche Université Laval Robert-Giffard, Quebec City, Quebec, Canada. evelyne.matteau.1@ulaval.ca
authors.forename: Evelyne
authors.initials: E
authors.lastname: Matteau
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dupré
authors.forename: Mélanie
authors.initials: M
authors.lastname: Langlois
authors.forename: Léonie
authors.initials: L
authors.lastname: Jean
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Thivierge
authors.forename: Pierre
authors.initials: P
authors.lastname: Provencher
authors.forename: Martine
authors.initials: M
authors.lastname: Simard
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000175:diagnosis; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards; D012720:Severity of Illness Index