title: Early-onset postirradiation sarcoma of the tongue after pseudotumor phase.
abstract: Radiation-induced sarcoma usually develops after an interval of more than 10 years from the completion of radiation therapy to the diagnosis of secondary sarcoma. However, the theory of radiation-induced transformation does not rule out postirradiation sarcomas with a short latency period. We experienced the case of a patient with postirradiation leiomyosarcoma of the tongue, which occurred 19 months after he had received chemoradiotherapy. Besides the short latency period, a pseudotumor stage developed between the time of radiation exposure and the development of leiomyosarcoma. In this article, we also describe an immunohistochemical approach to diagnose leiomyosarcoma and the efficacy of a gemcitabine and docetaxel regimen.
authors.affiliation: Department of Otolaryngology, Japanese Red Cross Society, Wakayama Medical Center, Wakayama, Japan. miyoshi-kyt@umin.ac.jp
authors.forename: Takushi
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Shinji
authors.initials: S
authors.lastname: Takebayashi
authors.forename: Chiaki
authors.initials: C
authors.lastname: Suzuki
authors.forename: Nao
authors.initials: N
authors.lastname: Hiwatashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ono
authors.forename: Makoto
authors.initials: M
authors.lastname: Miura
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D006104:Granuloma, Plasma Cell / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000209:etiology*; D012509:Sarcoma / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors; D014060:Tongue Diseases / Q000473:pathology / Q000532:radiotherapy; D014062:Tongue Neoplasms / Q000175:diagnosis / Q000209:etiology*