title: Laboratory of receptor pharmacology.
abstract: The Laboratory of Receptor Pharmacology studied the GABAB and muscarinic m2/m3 receptors present in primary cultures of rat cerebellar granule cells. From 1985 to 1992, multiple scientists showed the GABAB receptor had, at least, two affinity states, the low affinity receptor inhibiting adenylyl cyclase and the higher affinity receptor increasing intracellular calcium from ryanodine sensitive calcium stores. Muscarinic m2 receptors inhibit adenylyl cyclase and would undergo desensitization using, in part, similar mechanism of desensitization identified for the beta-adrenergic receptor coupled to adenylyl cyclase. Muscarinic m3 receptors increased intracellular calcium levels via inositol 3-phosphate-sensitive intracellular calcium stores.
authors.affiliation: Neurologic Care Associates, MacNeal Hospital, 3340 S. Oak Park Avenue Suite 200, Berwyn, IL 60402, United States. wwojcik@macneal.com
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Wojcik
mesh_terms: D000818:Animals; D006801:Humans; D009480:Neuropharmacology / Q000379:methods*; D043585:Receptor, Muscarinic M2 / Q000378:metabolism*; D043587:Receptor, Muscarinic M3 / Q000378:metabolism*; D018080:Receptors, GABA-B / Q000378:metabolism*
chemical_list: D043585:Receptor, Muscarinic M2; D043587:Receptor, Muscarinic M3; D018080:Receptors, GABA-B