title: Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine.
abstract: Long term intake of coffee is known to produce anxiety and suppression of appetite. 5- hydroxytryptamine (5-HT) acting via 5-HT-2C receptors elicits anorexia and anxiety. The present study is design to monitor metachloro phenyl piperazine (m-CPP) at a dose of 3mg/ml/kg, induces hypophagia and hypolocomotion in rats taking a solution of caffeine (a component of coffee and tea) or theophylline (a component of tea) as a sole source of water. We found that hypophagic and hypolocomotive effects of m-CPP were attenuated in theophylline but not in caffeine treated animals suggesting that long term intake of theophylline may attenuate anorexiogenic and anxiogenic effects of 5-HT. A possible role of 5-HT-2C receptors in the modulation of anxiety and appetite in people drinking coffee or tea discussed.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Nausheen
authors.initials: N
authors.lastname: Alam
authors.forename: Darakshan Jabeen
authors.initials: DJ
authors.lastname: Haleem
authors.forename: Rahila
authors.initials: R
authors.lastname: Najam
authors.forename: Syeda
authors.initials: S
authors.lastname: Haider
authors.forename: Shahida Perveen
authors.initials: SP
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects*; D010879:Piperazines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology*
chemical_list: D010879:Piperazines; D017366:Serotonin Receptor Agonists; D002110:Caffeine; D013806:Theophylline; C015068:1-(3-chlorophenyl)piperazine