title: Mini ways to stop a virus: microRNAs and HIV-1 replication.
abstract: Cellular restriction of HIV-1 replication has traditionally been thought of as protein mediated: APOBEC3G hypermutates HIV-1 genomic RNA, but is counteracted by Vif; Tetherin inhibits the release of budding virions but is counteracted by Vpu. In recent years, new evidence suggesting that miRNAs and other components of the miRNA pathway act as HIV-1 restriction factors has come to light, along with the identification of strategies that HIV-1 employs to surmount these host obstacles. In this article, we summarize and discuss the literature to date regarding the complex relationship between HIV-1 and miRNA-mediated inhibition.
authors.affiliation: Interdepartmental Program in Translational Biology & Molecular Medicine, Baylor College of Medicine, TX, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Chiang
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Rice