title: [Use of sugammadex in a patient with limb girdle muscular dystrophy].
abstract: Limb girdle muscular dystrophy, a chronic progressive muscular atrophic disease, leads to high sensitivity to depolarizing and non-depolarizing neuromuscular blocking agents. We report the successful use of the sugammadex in a patient with limb girdle muscular dystrophy (dysferlinopathy, Miyoshi distal myopathy) to reverse rocuronium-induced neuromuscular block. After neuromuscular recovery to a train-of-four ratio = 43%, we administered 3.2 mg x kg(-1) of sugammadex (200 mg) intravenously, reversing neuromuscular blockade to a train-of-four ratio = 95% within 3 min. Sugammadex can be used to reverse rocuronium-induced neuromuscular blockade in patients with limb girdle muscular dystrophy.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University, Shimotsuke 329-0498.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Mogi
authors.forename: Satomi
authors.initials: S
authors.lastname: Shiba
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hirabayashi
authors.forename: Norimasa
authors.initials: N
authors.lastname: Seo
mesh_terms: D000732:Androstanols / Q000037:antagonists & inhibitors*; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D006801:Humans; D007262:Infusions, Intravenous; D010535:Laparoscopy; D008875:Middle Aged; D049288:Muscular Dystrophies, Limb-Girdle / Q000150:complications*; D019148:Neuromuscular Blockade; D012004:Rectal Neoplasms / Q000150:complications / Q000601:surgery; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000008:administration & dosage* / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium