title: Does increased intake of salmon increase markers of oxidative stress in pregnant women? The salmon in pregnancy study.
abstract: The Salmon in Pregnancy Study provided two meals of salmon per week to pregnant women from week 20 of gestation; the control group maintained their habitual diet low in oily fish. Salmon is a rich source of marine n-3 fatty acids. Since marine n-3 fatty acids may increase oxidative stress, we investigated whether increased salmon consumption could affect markers of oxidative stress in mid and late pregnancy. Urinary 8-iso-prostaglandin F(2α), urinary 8-hydroxy-2'-deoxyguanosine, and plasma lipid peroxide concentrations did not change from week 20 to 38 of pregnancy and were not altered by increased consumption of salmon. Thus, increased intake of salmon during pregnancy does not increase oxidative stress, as judged by the markers of oxidative damage to lipids and DNA measured herein.
authors.affiliation: Oxidative Stress and Inflammation, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden.
authors.forename: Cruz E
authors.initials: CE
authors.lastname: García-Rodríguez
authors.forename: Johanna
authors.initials: J
authors.lastname: Helmersson-Karlqvist
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Mesa
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Miles
authors.forename: Paul S
authors.initials: PS
authors.lastname: Noakes
authors.forename: Maria
authors.initials: M
authors.lastname: Vlachava
authors.forename: Lefkothea-Stella
authors.initials: LS
authors.lastname: Kremmyda
authors.forename: Norma D
authors.initials: ND
authors.lastname: Diaper
authors.forename: Keith M
authors.initials: KM
authors.lastname: Godfrey
authors.forename: Philip C
authors.initials: PC
authors.lastname: Calder
authors.forename: Angel
authors.initials: A
authors.lastname: Gil
authors.forename: Samar
authors.initials: S
authors.lastname: Basu
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000652:urine; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004032:Diet; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D011247:Pregnancy / Q000097:blood* / Q000652:urine; D012474:Salmon; D017747:Seafood / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008054:Lipid Peroxides; C075750:8-epi-prostaglandin F2alpha; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003404:Creatinine; D015237:Dinoprost; D003849:Deoxyguanosine