title: SiRNA delivery: challenges and role of carrier systems.
abstract: Gene silencing by RNA interference is a rapidly growing therapeutic area for managing diseases. Despite research advances in this direction, the poor cellular uptake of synthetic small interfering RNAs is a major impediment to their clinical applications. Polymer and lipid-based systems are attractive carrier systems for delivery of siRNA and provide options for desirable engineering of carrier particles. In this review, there is a detailed discussion of RNAi delivery systems and recent advances in the field.
authors.affiliation: Institute of Pharmacy, Department of Pharmaceutics, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Germany. ranjita@arcsindia.com
authors.forename: R
authors.initials: R
authors.lastname: Shegokar
authors.forename: L
authors.initials: L
authors.lastname: Al Shaal
authors.forename: P R
authors.initials: PR
authors.lastname: Mishra
mesh_terms: D000818:Animals; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004655:Emulsions; D018390:Gene Targeting / Q000379:methods; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008081:Liposomes; D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000235:genetics / Q000627:therapeutic use
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D008081:Liposomes; D011108:Polymers; D034741:RNA, Small Interfering