title: Chromatin-based mechanisms of renal epithelial differentiation.
abstract: Successful regenerative renal medicine depends on understanding the molecular mechanisms by which diverse phenotypes of epithelial cells differentiate from metanephric mesenchyme to populate nephrons. Whereas many genes are maintained in a poised state within the population of pluripotent progenitors, specialized epithelial functions reflect the selective expression of a subset of genes and the repression of all others. Here we highlight some common mechanisms of cell differentiation and epigenetic regulation to discuss their implications for renal epithelial development, repair, and disease.
authors.affiliation: Department of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA. surendran_k@wustl.edu
authors.forename: Kameswaran
authors.initials: K
authors.lastname: Surendran
authors.forename: Raphael
authors.initials: R
authors.lastname: Kopan
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002843:Chromatin / Q000378:metabolism*; D044127:Epigenesis, Genetic; D004847:Epithelial Cells / Q000166:cytology*; D007668:Kidney / Q000166:cytology* / Q000378:metabolism; D007674:Kidney Diseases / Q000209:etiology; D012038:Regeneration; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D002843:Chromatin; D014157:Transcription Factors