title: [Case of ventricular fibrillation in patients with brugada type electrocardiogram during surgery].
abstract: We described a case of ventricular fibrillation in patients with Brugada type electrocardiogram (ECG) during surgery. A 63-year-old man underwent lung lobectomy under combined general and epidural anesthesia. His preoperative ECG showed Brugada type, but he was asymptomatic and did not have a family history of sudden death. Anesthesia was induced using propofol, vecuronium and fentanyl, and maintained using propofol and lidocaine via epidural catheter. One hour into operation, ventricular fibrillation developed. After cardiac compression in a few seconds, sinus rhythm was restored and blood pressure was elevated. When the wound was sutured, ventricular fibrillation occurred again. Defibrillation was attempted immediately and sinus rhythm was restored. We diagnosed coronary spastic angina after acetylcholine challenge test. Previous report describes that the incidence of vasospasm in Brugada type ECG cases is relatively higher than those with the normal ECG. In addition, ventricular fibrillation might be induced by local anesthetics because these agents were administrated 10 minutes before the few events and balance of autonomic nervous system was changed. We conclude that strict monitoring and immediate treatment for ventricular fibrillation are important for anesthetic management in asymptomatic patient with Brugada type ECG.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Nankoku 783-8505.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Yatabe
authors.forename: Miho
authors.initials: M
authors.lastname: Hirohashi
authors.forename: Sonoe
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Maeda
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamashita
authors.forename: Masataka
authors.initials: M
authors.lastname: Yokoyama
mesh_terms: D000109:Acetylcholine; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000009:adverse effects; D053840:Brugada Syndrome / Q000139:chemically induced*; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000175:diagnosis; D004562:Electrocardiography; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced* / Q000628:therapy; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D011013:Pneumonectomy; D014693:Ventricular Fibrillation / Q000139:chemically induced* / Q000628:therapy
chemical_list: D000779:Anesthetics, Local; D000109:Acetylcholine