title: Effect of human umbilical cord blood stem cells on flash visual evoked potential in traumatic optic neuropathy in rats.
abstract: OBJECTIVE
  To investigate the effect of human umbilical cord blood stem cells on flash visual evoked potentials (F-VEP) of the traumatic optic neuropathy rats.
  
  
  METHODS
  Forty-eight Sprague-Dawley rats were randomly divided into an injury group (Group A) and 3 treatment groups (Groups B, C, and D). A traumatic optic neuropathy model was built in Group A, and the rats in Groups B, C, and D were injected with the neurotrophic factor, human umbilical cord blood stem cells, and the mixture of the neurotrophic factor and human umbilical cord blood stem cells, respectively. F-VEP was recorded in both eyes of rats at the 1st h, 1st week, 2nd week, 3rd week, and 4th week after the optic nerve injury.
  
  
  RESULTS
  At all time points, there were significant difference in the wave latency and amplitude between Group A and normal control eyes (P<0.01). The differences of the wave latency and amplitude between Group A and Groups B, C, and D were statistically significant at various time points after the injury except for the wave latency at the 1st h post-operation (P<0.05). The amplitude in Group D was higher while the latency was shorter than those of Group B at all time points since the 1st week (P<0.05). The comparisons at the same point in the remaining treatment groups were not significantly different (P<0.05).
  
  
  CONCLUSIONS
  The mixture of human umbilical cord blood stem cells and neurotrophic factor has a promotion effect for the recovery of F-VEP of optic nerve in traumatic optic neuropathy in rats to some degrees.
authors.affiliation: Department of Ophthalmology, Second Xiangya Hospital, Changsha 410011, China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Zhu
authors.forename: Bing
authors.initials: B
authors.lastname: Jiang
authors.forename: Pu
authors.initials: P
authors.lastname: Zhang
authors.forename: Dan
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000818:Animals; D036101:Cord Blood Stem Cell Transplantation; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009414:Nerve Growth Factors / Q000627:therapeutic use; D020221:Optic Nerve Injuries / Q000503:physiopathology* / Q000628:therapy*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009414:Nerve Growth Factors