title: Klotho and the aging process.
abstract: The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life. Since then, various functional aspects of the klotho gene have been investigated, leading to the identification of multiple novel endocrine axes that regulate various metabolic processes and an unexpected link between mineral metabolism and aging. The purposes of this review were to overview recent progress on Klotho research and to discuss a novel aging mechanism.
authors.affiliation: Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Makoto.Kuro-o@UTSouthwestern.edu
authors.forename: Makoto
authors.initials: M
authors.lastname: Kuro-o
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002908:Chronic Disease; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005966:Glucuronidase / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism / Q000503:physiopathology; D000090265:Klotho Proteins; D010641:Phenotype; D010710:Phosphates / Q000378:metabolism; D016226:Phosphorus, Dietary / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D010710:Phosphates; D016226:Phosphorus, Dietary; D005346:Fibroblast Growth Factors; D005966:Glucuronidase; D000090265:Klotho Proteins