title: Sox2 nuclear expression is closely associated with poor prognosis in patients with histologically node-negative oral tongue squamous cell carcinoma.
abstract: Sox2 is a marker of embryonic stem cell pluripotency and plays an important role in tumor progression. However, Sox2 expression in oral tongue squamous cell carcinoma (OTSCC) and its correlation with patients' prognosis have not been investigated so far. In this study, we detected the expression of Sox2 in 82 patients with histologically node-negative (pN0) OTSCC by immunohistochemistry, and evaluated its correlation with clinicopatologic factors and disease prognosis. Sox2 positive expression was detected in 62.2% patients and showed a significant association with large tumor size. Survival analysis showed that patients with Sox2 positive expression had significantly poorer overall, cancer-specific and disease-free survivals than those with Sox2 negative expression at 5years after operation (P=0.004, 0.004 and 0.001, respectively). Multivariate analysis demonstrated that Sox2 positive expression was an independent prognosticator of unfavorable overall, cancer-specific and disease-free survivals (P=0.032, 0.035 and 0.011, respectively). According to our results, Sox2 positive expression was frequent in pN0 OTSCC and involved in tumor progression. The measurement of Sox2 expression may be helpful in predicting relapse and prognosis of patients with pN0 OTSCC.
authors.affiliation: Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, PR China.
authors.forename: Lutao
authors.initials: L
authors.lastname: Du
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Yang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xiao
authors.forename: Chuanxin
authors.initials: C
authors.lastname: Wang
authors.forename: Xuhua
authors.initials: X
authors.lastname: Zhang
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Guixi
authors.initials: G
authors.lastname: Zheng
authors.forename: Shun
authors.initials: S
authors.lastname: Wang
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Dong
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055748:SOXB1 Transcription Factors / Q000378:metabolism*; D016019:Survival Analysis; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors