title: Francisella Recognition by Inflammasomes: Differences between Mice and Men.
abstract: Pathogen recognition by intracellular sensors involves the assembly of a caspase-1 activation machine termed the inflammasome. Intracellular pathogens like Francisella that gain access to the cytosolic detection systems are useful tools to uncover the details of caspase-1 activation events. This review overviews Francisella function in the mononuclear phagocyte with particular attention to inflammasome versus pyroptosome roles and outlines differences between mouse and human caspase-1 activation pathways. Specific attention is placed on functional differences between human and murine pyrin as an intracellular recognition molecule for Francisella.
authors.affiliation: Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Center for Microbial Interface Biology, The Ohio State University Columbus, OH, USA.
authors.forename: Mikhail A
authors.initials: MA
authors.lastname: Gavrilin
authors.forename: Mark D
authors.initials: MD
authors.lastname: Wewers