title: Surgical margin status of specimen and oncological outcomes after laparoscopic radical prostatectomy: experience after 400 procedures.
abstract: OBJECTIVE
  To analyse the surgical margins status of prostatic glands, resected by laparoscopic radical prostatectomy (LRP) for prostate cancer, and to correlate it with biochemical free survival rate (BFSR).
  
  
  METHODS
  Data were collected prospectively from 405 patients undergoing LRP from 2000 to 2009 at a single institution. Patients undergoing neoadjuvant and/or adjuvant therapy were excluded from the study. Three hundred patients matched all the criteria: 232 of these had negative surgical margins (NSM) and 68 positive surgical margins (PSM). The median follow-up was 62 months. PSM were classified based on the following: (a) the number of margins, monofocal and multifocal, (b) the location, apical or non-apical and (c) the extension, ≤2.8 mm or >2.8 mm. These data were then entered into a multivariate analysis.
  
  
  RESULTS
  Overall BFSR rate was 67.6% in PSM group and 88.8% in NSM group (P < 0.001). We registered a HR of 3.78 in multivariate analysis (P < 0.001). In terms of the extension, BFSR in univariate survival analysis was 77.8% in ≤2.8 mm PSM and 38.9% in >2.8 mm PSM (P = 0.003), with a HR of 5.68 (P = 0.011) in multivariate analysis. BFSR was 59% for apical margins and 77% for non-apical margins (P = 0.038). In monofocal margins, BFSR was 73%, while 53% in multifocal (P = 0.014).
  
  
  CONCLUSIONS
  We recommend careful evaluation of patients with PSM following LRP, especially if they are more than 2.8 mm, and in these cases, adjuvant therapy should be considered after radical surgery.
authors.affiliation: Division of Urology, Department of Clinical and Biological Sciences, University of Turin, "San Luigi" Hospital, Regione Gonzole 10, 10043 Orbassano, Turin, Italy. porpiglia@libero.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Porpiglia
authors.forename: Cristian
authors.initials: C
authors.lastname: Fiori
authors.forename: Matteo
authors.initials: M
authors.lastname: Manfredi
authors.forename: Susanna
authors.initials: S
authors.lastname: Grande
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Poggio
authors.forename: Enrico
authors.initials: E
authors.lastname: Bollito
authors.forename: Mauro
authors.initials: M
authors.lastname: Papotti
authors.forename: Roberto Mario
authors.initials: RM
authors.lastname: Scarpa
mesh_terms: D000368:Aged; D018572:Disease-Free Survival; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D011446:Prospective Studies; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*