title: False-positive PET/CT for lymphoma recurrence secondary to Langerhans cell histiocytosis.
abstract: A 28-year-old man with a history of Hodgkin lymphoma that was intensely [F-18]fluoro-2-deoxy-D-glucose-avid at diagnosis had achieved complete remission following appropriate therapy. On surveillance positron emission tomography/computed tomography (CT), new, intensely [F-18]fluoro-2-deoxy-D-glucose-avid lesions (lytic on CT) were seen within the vertebral body of C7, left scapula, and right glenoid. The findings of a biopsy revealed these lesions to be Langerhans cell histiocytosis. Langerhans cell histiocytosis arising in the context of lymphoma is a well-documented phenomenon, and its appearance on positron emission tomography/CT cannot be conclusively distinguished from lymphoma recurrence. This manuscript emphasizes the necessity of biopsy to ensure correct diagnosis and subsequent correct therapy.
authors.affiliation: Department of Radiology, Penn State Hershey Medical Center, Hershey, PA, USA.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Fotos
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Flemming
authors.forename: Mark
authors.initials: M
authors.lastname: Tulchinsky
mesh_terms: D000328:Adult; D005189:False Positive Reactions; D019788:Fluorodeoxyglucose F18; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications*; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D049268:Positron-Emission Tomography; D012008:Recurrence; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18