title: Synthesis and biological evaluation of a polyglutamic acid-dopamine conjugate: a new antiangiogenic agent.
abstract: Dopamine has previously been shown to inhibit angiogenesis in vitro and in vivo, but its clinical applications in this context are severely limited by its short half-life. Here we report the synthesis of a polyglutamic acid-dopamine conjugate and show that conjugation significantly extends (from 1 to 24 h) dopamine's antiangiogenic activity in vitro and in vivo. These findings form the basis for the development of a new class of agents for the treatment of angiogenesis-dependent diseases.
authors.affiliation: Reading School of Pharmacy, University of Reading, Whiteknights, RG6 6AD, Berkshire, UK.
authors.forename: Cristina
authors.initials: C
authors.lastname: Fante
authors.forename: Anat
authors.initials: A
authors.lastname: Eldar-Boock
authors.forename: Ronit
authors.initials: R
authors.lastname: Satchi-Fainaro
authors.forename: Helen M I
authors.initials: HM
authors.lastname: Osborn
authors.forename: Francesca
authors.initials: F
authors.lastname: Greco
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002465:Cell Movement; D004298:Dopamine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D055806:Microvessels / Q000187:drug effects / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D011099:Polyglutamic Acid / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014471:Umbilical Veins / Q000166:cytology; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology
chemical_list: D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A; D011099:Polyglutamic Acid; D004298:Dopamine