title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.
abstract: Depression is currently the fourth leading cause of disease or disability worldwide. Antidepressant is approved for the treatment of major depression (including paediatric depression), obsessive-compulsive disorder (in both adult and paediatric populations), bulimia nervosa, panic disorder and premenstrual dysphoric disorder. Antidepressant is a psychiatric medication used to alleviate mood disorders, such as major depression and dysthymia and anxiety disorders such as social anxiety disorder. Many drugs produce an antidepressant effect, but restrictions on their use have caused controversy and off-label prescription a risk, despite claims of superior efficacy. Our current understanding of its pathogenesis is limited and existing treatments are inadequate, providing relief to only a subset of people suffering from depression. Reviews of literature suggest that heterocyclic moieties and their derivatives has proven success in treating depression.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, Hamdard Nagar, New Delhi - 110 062, India.
authors.forename: Nadeem
authors.initials: N
authors.lastname: Siddiqui
authors.lastname: Andalip
authors.forename: Sandhya
authors.initials: S
authors.lastname: Bawa
authors.forename: Ruhi
authors.initials: R
authors.lastname: Ali
authors.forename: Obaid
authors.initials: O
authors.lastname: Afzal
authors.forename: M Jawaid
authors.initials: MJ
authors.lastname: Akhtar
authors.forename: Bishmillah
authors.initials: B
authors.lastname: Azad
authors.forename: Rajiv
authors.initials: R
authors.lastname: Kumar