title: Molluscicidal effect of Eomecon chionantha alkaloids against Oncomelania hupensis snails.
abstract: The molluscicidal effects of Eomecon chionantha alkaloids (ECA) against Oncomelania hupensis snails were determined by immersion method. The molluscicidal effect was positively related to ECA concentration, immersion time and temperature of the immersion solution. The mortality of the snails reached 100% by 72 hours in ECA at a concentration of 2.5 mg/l at 25 degrees C. The alanine aminotransferase (ALT) level of liver cells treated with ECA was higher than controls at 24 and 36 hours (57.7 and 60.3 U/l versus 39.2 and 49.2 U/1, respectively) but the level decreased at 48-72 hours after treatment. The decrease points to the toxic effect of ECA against liver cells. After ECA treatment, the liver cells were edematous with swollen or disintegrating nuclei; they were enlarged and had vacuolated rER; they had dilated and vesiculated mitochondria with broken crests further indicating a hepatotoxic effect of ECA in O. hupensis snails. ECA has a molluscicidal effect that may be of practical use in the field to control O. hupensis snails.
authors.affiliation: Medical College of Hunan Normal University, Changsha, Hunan, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Peng
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Qiongyao
authors.initials: Q
authors.lastname: Huang
authors.forename: Nianmeng
authors.initials: N
authors.lastname: Liu
authors.forename: Huazhong
authors.initials: H
authors.lastname: Yang
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
authors.forename: Qi
authors.initials: Q
authors.lastname: Hu
authors.forename: Fang
authors.initials: F
authors.lastname: Feng
authors.forename: Chonghe
authors.initials: C
authors.lastname: Jiang
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure; D008975:Molluscacides / Q000494:pharmacology*; D028101:Papaveraceae; D010936:Plant Extracts / Q000494:pharmacology*; D012552:Schistosomiasis / Q000517:prevention & control*; D012908:Snails / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000470:Alkaloids; D008975:Molluscacides; D010936:Plant Extracts; D000410:Alanine Transaminase