title: [Tapentadol is a new, strongly efficative analgeticum with dual effect mechanisms].
abstract: Tapentadol exerts its analgesic effects through opioid receptor agonism and noradrenaline reuptake inhibition in the central nervous system. Clinical studies show that tapentadol effectively relieves moderate to severe pain in both post-operative and chronic pain. In these trials with equianalgesic doses of tapentadol and oxycodone, treatment with tapentadol was associated with significantly fewer gastrointestinal-related adverse events. Furthermore, in a placebo-controlled study, tapentadol has shown good efficacy in painful diabetic polyneuropathy.
authors.affiliation: Grünenthal Denmark ApS, Arne Jacobsens Allé 7, 2300 København S, Denmark. camilla.staahl@grunenthal.com
authors.forename: Camilla
authors.initials: C
authors.lastname: Staahl
authors.forename: Asbjørn Mohr
authors.initials: AM
authors.lastname: Drewes
authors.forename: Niels-Henrik
authors.initials: NH
authors.lastname: Jensen
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D001168:Arthritis / Q000188:drug therapy; D001416:Back Pain / Q000188:drug therapy; D002908:Chronic Disease; D003929:Diabetic Neuropathies / Q000188:drug therapy; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy; D010149:Postoperative Pain / Q000188:drug therapy; D010636:Phenols / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D000077432:Tapentadol; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D010636:Phenols; D000077432:Tapentadol