title: [Ischemic lesions in kidneys after extracorporeal shock wave lithotripsy demonstrated by Proton NMR spectroscopy of urine samples].
abstract: OBJECTIVE
  The aim of this prospective study was to investigate the effect of extracorporeal shock wave lithotripsy (SWL) on kidneys of patients with pyelic stone disease. The effects of SWL were assessed by high-resolution proton nuclear magnetic resonance (HNMR) spectroscopy of urine samples.
  
  
  METHODS
  Twenty-three patients, aged 31-80years (mean: 55years), with pyelic stone disease were investigated before and after SWL. Multiparameter analysis was performed by HNMR spectroscopy of urine samples collected before and 5h after SWL (second miction post-SWL).
  
  
  RESULTS
  The most relevant resonances determined by HNMR spectroscopy were acetate, lactate, trimethylamine N-oxide and amino acids. Excretion of these markers increased significantly in comparison with pre-SWL urinary samples.
  
  
  CONCLUSIONS
  These results show that early ischemic damage occurs after SWL. Post-SWL. HNMR spectroscopy is an effective tool for noninvasive follow-up of renal damage.
authors.affiliation: Service d'urologie, hôpitaux de Brabois, CHU de Nancy, avenue de Bourgogne, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: N
authors.initials: N
authors.lastname: Berte
authors.forename: L
authors.initials: L
authors.lastname: Cayzergues
authors.forename: F
authors.initials: F
authors.lastname: Meyer
authors.forename: H
authors.initials: H
authors.lastname: Jira
authors.forename: M
authors.initials: M
authors.lastname: Eugene
authors.forename: M
authors.initials: M
authors.lastname: Conti
authors.forename: S
authors.initials: S
authors.lastname: Loric
authors.forename: Y
authors.initials: Y
authors.lastname: Hammoudi
authors.forename: G
authors.initials: G
authors.lastname: Benoit
authors.forename: S
authors.initials: S
authors.lastname: Droupy
authors.forename: J
authors.initials: J
authors.lastname: Hubert
authors.forename: P
authors.initials: P
authors.lastname: Eschwege
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007511:Ischemia / Q000175:diagnosis* / Q000209:etiology* / Q000652:urine; D007668:Kidney / Q000098:blood supply*; D007669:Kidney Calculi / Q000628:therapy; D008096:Lithotripsy / Q000009:adverse effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011522:Protons
chemical_list: D011522:Protons