title: Local giant cell foreign body reaction after silicone injection for fecal incontinence in humans: two case reports.
abstract: Since the 1990s, one of the methods used for treating fecal incontinence due to internal anal sphincter defects has been the injection of bulking agents. The aim of this paper is to report two cases of local giant cell foreign body reaction after injection of PTQ(TM) in humans. To the best of the authors' knowledge, this is the first report of an adverse immune response to silicone injection in humans.
authors.affiliation: Department of Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6202 AZ, Maastricht, The Netherlands. b.van.wunnik@mumc.nl
authors.forename: B
authors.initials: B
authors.lastname: van Wunnik
authors.forename: A
authors.initials: A
authors.lastname: Driessen
authors.forename: C
authors.initials: C
authors.lastname: Baeten
mesh_terms: D001672:Biocompatible Materials / Q000009:adverse effects* / Q000627:therapeutic use; D005242:Fecal Incontinence / Q000188:drug therapy; D005549:Foreign-Body Reaction / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D015743:Giant Cells, Foreign-Body / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012828:Silicones / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D001672:Biocompatible Materials; D012828:Silicones