title: Evolution of antimicrobial resistance of Acinetobacter baumannii in a university hospital.
abstract: OBJECTIVE
  To investigate the susceptibility pattern and the molecular epidemiology of Acinetobacter baumannii isolates in two periods (1994-1996 and 2004-2007) in Londrina University Hospital.
  
  
  RESULTS
  Antimicrobial susceptibility of 150 A. baumannii isolates was assessed by disc diffusion and agar dilution methods. Genetic similarity amongst the isolates was evaluated by ERIC-PCR. Resistance of A. baumannii to carbapenems increased from 2% (1994-1996) to 73% (2004-2007). Thirty-eight clones were detected.
  
  
  CONCLUSIONS
  The results of the study suggest that the high prevalence of carbapenem resistance amongst Acinetobacter baumannii organisms in this institution is not caused by the spread of a predominant clone.
  
  
  CONCLUSIONS
  This work reinforces the importance monitoring antimicrobial susceptibility rates.
authors.affiliation: Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil.
authors.forename: G F
authors.initials: GF
authors.lastname: Viana
authors.forename: S M
authors.initials: SM
authors.lastname: dos Santos Saalfeld
authors.forename: L B
authors.initials: LB
authors.lastname: Garcia
authors.forename: C L
authors.initials: CL
authors.lastname: Cardoso
authors.forename: M
authors.initials: M
authors.lastname: Pelisson
authors.forename: M C B
authors.initials: MC
authors.lastname: Tognim
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents; D001938:Brazil; D015780:Carbapenems / Q000494:pharmacology*; D006785:Hospitals, University; D006801:Humans; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D015780:Carbapenems; D001618:beta-Lactamases