title: Cochlin-tomoprotein (CTP) detection test identifies traumatic perilymphatic fistula due to penetrating middle ear injury.
abstract: CONCLUSIONS
  The cochlin-tomoprotein (CTP) detection test can be used to make a definite, objective diagnosis of traumatic perilymphatic fistula (PLF), and therefore offers valuable information on patient selection for surgical treatment.
  
  
  OBJECTIVE
  Penetrating middle ear injury can cause traumatic PLF, which is a surgically treatable otologic emergency. Recently, we have reported on CTP, a novel perilymph-specific protein. The purpose of this study was to determine if the CTP detection test is useful for the diagnosis of traumatic PLF.
  
  
  METHODS
  This was a prospective study of CTP detection in penetrating middle ear injury cases with tympanic membrane perforation and hearing loss.
  
  
  RESULTS
  A total of seven individuals were included in this study. CTP was detected in three of four cases with posterosuperior quadrant perforation of the tympanic membrane. In one of these three cases, even though the high resolution CT scan was not suggestive of PLF and the perilymph leakage could not be visualized intraoperatively, the CTP detection test was able to detect PLF. In two cases, the preoperative positive test results enabled us to make a diagnosis of PLF and a decision for surgical treatment. CTP was not detected in the cases with anterior or inferior tympanic membrane perforation.
authors.affiliation: Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan. ctp16kdaplf@nms.ac.jp
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ikezono
authors.forename: Susumu
authors.initials: S
authors.lastname: Shindo
authors.forename: Kuwon
authors.initials: K
authors.lastname: Sekine
authors.forename: Kyoko
authors.initials: K
authors.lastname: Shiiba
authors.forename: Han
authors.initials: H
authors.lastname: Matsuda
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kusama
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Koizumi
authors.forename: Kazuki
authors.initials: K
authors.lastname: Sugizaki
authors.forename: Satomi
authors.initials: S
authors.lastname: Sekiguchi
authors.forename: Ryohei
authors.initials: R
authors.lastname: Kataoka
authors.forename: Ruby
authors.initials: R
authors.lastname: Pawankar
authors.forename: Shunkichi
authors.initials: S
authors.lastname: Baba
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yagi
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Okubo
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone; D015415:Biomarkers / Q000032:analysis; D015153:Blotting, Western; D001844:Bone Conduction; D002648:Child; D004432:Ear, Middle / Q000293:injuries*; D016326:Extracellular Matrix Proteins / Q000032:analysis*; D005260:Female; D005402:Fistula / Q000175:diagnosis*; D005500:Follow-Up Studies; D006314:Hearing Loss, Conductive / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007759:Labyrinth Diseases / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010498:Perilymph / Q000737:chemistry / Q000502:physiology*; D011237:Predictive Value of Tests; D020033:Protein Isoforms / Q000032:analysis*; D040901:Proteomics; D014057:Tomography, X-Ray Computed; D018058:Tympanic Membrane Perforation / Q000175:diagnosis*; D014717:Vertigo / Q000175:diagnosis / Q000209:etiology; D014950:Wounds, Penetrating / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; C110668:COCH protein, human; D016326:Extracellular Matrix Proteins; D020033:Protein Isoforms