title: Solid lipid nanoparticles suspension versus commercial solutions for dermal delivery of minoxidil.
abstract: Solid lipid nanoparticles have been reported as possible carrier for skin drug delivery. Solid lipid nanoparticles are produced from biocompatible and biodegradable lipids. Solid lipid nanoparticles made of semi-synthetic triglycerides stabilized with a mixture of polysorbate and sorbitan oleate were loaded with 5% of minoxidil. The prepared systems were characterized for particle size, pH and drug content. Ex vivo skin penetration studies were performed using Franz-type glass diffusion cells and pig ear skin. Ex vivo skin corrosion studies were realized with a method derived from the Corrositex(®) test. Solid lipid nanoparticles suspensions were compared to commercial solutions in terms of skin penetration and skin corrosion. Solid lipid nanoparticles suspensions have been shown as efficient as commercial solutions for skin penetration; and were non-corrosive while commercial solutions presented a corrosive potential. Solid lipid nanoparticles suspensions would constitute a promising formulation for hair loss treatment.
authors.affiliation: Université de Lyon, Lyon cedex 08, France. karine.poret-padois@univ-lyon1.fr
authors.forename: Karine
authors.initials: K
authors.lastname: Padois
authors.forename: Céline
authors.initials: C
authors.lastname: Cantiéni
authors.forename: Valérie
authors.initials: V
authors.lastname: Bertholle
authors.forename: Claire
authors.initials: C
authors.lastname: Bardel
authors.forename: Fabrice
authors.initials: F
authors.lastname: Pirot
authors.forename: Françoise
authors.initials: F
authors.lastname: Falson
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D015194:Diffusion Chambers, Culture; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D008055:Lipids / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics; D008914:Minoxidil / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics*; D053758:Nanoparticles / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry*; D010316:Particle Size; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012869:Skin Absorption / Q000187:drug effects*; D023422:Skin Irritancy Tests / Q000379:methods; D012996:Solutions / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D013535:Suspensions / Q000008:administration & dosage / Q000009:adverse effects / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D013552:Swine
chemical_list: D004337:Drug Carriers; D008055:Lipids; D012996:Solutions; D013535:Suspensions; D008914:Minoxidil