title: [The significance of H. pylori eradication in NSAIDs ulcer].
abstract: The significance of H. pylori eradication for NSAIDs induced gastroduodenal ulcer has not been clarified. NSAIDs and H. pylori infection are independent causal factors for gastroduodenal mucosal injuries. However, the interaction between these two factors is complicated. H. pylori eradication can reduce the risk of NSAIDs induced ulcer in NSAIDs naive patients. However, H. pylori eradication is not recommended in NSAIDs user because of no ulcer suppression and ulcer healing delay. In prevention of NSAIDs induced ulcer recurrence, H. pylori eradication plus PPI treatment is necessary.
authors.affiliation: Division of Endoscopy, Hokkaido University Hospital.
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Kato
authors.forename: Shouko
authors.initials: S
authors.lastname: Ono
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Mabe
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000209:etiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal