title: Interferon-gamma release assay performance for diagnosing tuberculosis disease in 0- to 5-year-old children.
abstract: QuantiFERON-TB Gold In-Tube performance was evaluated in 19 French immunocompetent children (0.29-5.36 years; median: 1.52) with active tuberculosis. The rate of indeterminates results was 0/19 and the rates of positivity were 6/10 and 9/9 in <2 and 2- to 5-year-old children, respectively. QuantiFERON-TB Gold In-Tube in association with tuberculin skin test could improve diagnosis of tuberculosis even in young children.
authors.affiliation: Laboratory of Immunology, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris 7 Denis Diderot University, Paris, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Debord
authors.forename: Agathe
authors.initials: A
authors.lastname: De Lauzanne
authors.forename: Nadège
authors.initials: N
authors.lastname: Gourgouillon
authors.forename: Valérie
authors.initials: V
authors.lastname: Guérin-El Khourouj
authors.forename: Béatrice
authors.initials: B
authors.lastname: Pédron
authors.forename: Joel
authors.initials: J
authors.lastname: Gaudelus
authors.forename: Albert
authors.initials: A
authors.lastname: Faye
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Sterkers
mesh_terms: D002675:Child, Preschool; D005260:Female; D005602:France; D006801:Humans; D007121:Immunocompetence; D007223:Infant; D007231:Infant, Newborn; D007371:Interferon-gamma / Q000032:analysis* / Q000276:immunology; D059425:Interferon-gamma Release Tests; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000302:isolation & purification; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014374:Tuberculin Test; D014376:Tuberculosis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology
chemical_list: D007371:Interferon-gamma