title: Clinical EEG in cognitively impaired patients with Parkinson's Disease.
abstract: Parkinson's Disease Dementia (PD-D) is one of the most important non-motor signs in advanced PD and is the most influencing factor predicting nursing home placement. PD-related Mild Cognitive Impairment (PD-MCI) is a potential prodromal stage of PD-D. The Grand Total EEG (GTE) score is a rating scale for clinical EEG (Electroencephalography) analyses which is useful in the evaluation of different types of dementia. The purpose of the present study was to investigate the relationship between a short version of the GTE score and severity of cognitive deficits in PD. Nineteen patients with PD underwent neuropsychological testing and resting state EEG. Significant correlations with deteriorating cognition (combined Mini Mental Status Examination/Clock Drawing Test) were found for the overall short GTE score (Spearman Rank correlation, ρ=-.6; p<.05) and for the subscore "Frequency of Rhythmic Background Activity" (ρ=-.6; p<.05), indicating that these EEG measures increase with deteriorating cognition.
authors.affiliation: Department of Neurology, University Hospital Basel, Switzerland.
authors.forename: Nina
authors.initials: N
authors.lastname: Schlede
authors.forename: Ronan
authors.initials: R
authors.lastname: Zimmermann
authors.forename: Michael M
authors.initials: MM
authors.lastname: Ehrensperger
authors.forename: Ute
authors.initials: U
authors.lastname: Gschwandtner
authors.forename: Martin
authors.initials: M
authors.lastname: Hardmeier
authors.forename: Florian
authors.initials: F
authors.lastname: Hatz
authors.forename: Andreas U
authors.initials: AU
authors.lastname: Monsch
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Naegelin
authors.forename: Peter
authors.initials: P
authors.lastname: Fuhr
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000209:etiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications*; D018709:Statistics, Nonparametric