title: Late effects of childhood leukemia therapy.
abstract: As survival rates for children treated for childhood cancers become significantly better, the focus is increasingly on determining the late effects of treatments and the best ways to monitor for them and prevent their occurrence. This review focuses on recent literature discussing the late effects of treatment in patients treated for acute myeloid leukemia and acute lymphoblastic leukemia during childhood. The late effects of therapy for childhood leukemia include secondary malignancy, cardiotoxicity, obesity, endocrine abnormalities, reproductive changes, neurocognitive deficits, and psychosocial effects. As clinicians have become more aware of the late effects of therapy, treatment regimens have been changed to decrease late effects, but patients still require long-term follow-up for their prevention and treatment.
authors.affiliation: Division of Pediatric Hematology/Oncology, Children's Mercy Hospital, Kansas City, MO 64108, USA. jmfulbright@cmh.edu
authors.forename: Joy M
authors.initials: JM
authors.lastname: Fulbright
authors.forename: Sripriya
authors.initials: S
authors.lastname: Raman
authors.forename: Wendy S
authors.initials: WS
authors.lastname: McClellan
authors.forename: Keith J
authors.initials: KJ
authors.lastname: August
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D016543:Central Nervous System Neoplasms / Q000556:secondary; D002648:Child; D004700:Endocrine System Diseases / Q000139:chemically induced / Q000209:etiology; D005298:Fertility / Q000187:drug effects; D006130:Growth Disorders / Q000139:chemically induced / Q000209:etiology; D006331:Heart Diseases / Q000139:chemically induced / Q000209:etiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology; D009765:Obesity / Q000139:chemically induced / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000473:pathology; D013315:Stress, Psychological
chemical_list: D000970:Antineoplastic Agents