title: Brain tumour and infiltrations dosimetry of boron neutron capture therapy combined with 252Cf brachytherapy.
abstract: This article presents a dosimetric investigation of boron neutron capture therapy (BNCT) combined with (252)Cf brachytherapy for brain tumour control. The study was conducted through computational simulation in MCNP5 code, using a precise and discrete voxel model of a human head, in which a hypothetical brain tumour was incorporated. A boron concentration ratio of 1:5 for healthy-tissue: tumour was considered. Absorbed and biologically weighted dose rates and neutron fluency in the voxel model were evaluated. The absorbed dose rate results were exported to SISCODES software, which generates the isodose surfaces on the brain. Analyses were performed to clarify the relevance of boron concentrations in occult infiltrations far from the target tumour, with boron concentration ratios of 1:1 up to 1:50 for healthy-tissue:infiltrations and healthy-tissue:tumour. The average biologically weighted dose rates at tumour area exceed up to 40 times the surrounding healthy tissue dose rates. In addition, the biologically weighted dose rates from boron have the main contribution at the infiltrations, especially far from primary tumour. In conclusion, BNCT combined with (252)Cf brachytherapy is an alternative technique for brain tumour treatment because it intensifies dose deposition at the tumour and at infiltrations, sparing healthy brain tissue.
authors.affiliation: Departamento de Engenharia Nuclear,  Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte 31270-010,  Brasil.
authors.forename: Sâmia F
authors.initials: SF
authors.lastname: Brandão
authors.forename: Tarcísio P R
authors.initials: TP
authors.lastname: Campos
mesh_terms: D001895:Boron / Q000737:chemistry; D016754:Boron Neutron Capture Therapy; D001918:Brachytherapy / Q000379:methods*; D001921:Brain / Q000528:radiation effects; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002142:Californium / Q000032:analysis*; D003198:Computer Simulation; D006801:Humans; D007554:Isotopes / Q000032:analysis*; D008094:Lithium / Q000737:chemistry; D019047:Phantoms, Imaging; D011835:Radiation Protection / Q000379:methods; D011874:Radiometry / Q000379:methods*; D012008:Recurrence; D012984:Software
chemical_list: D007554:Isotopes; D002142:Californium; D008094:Lithium; D001895:Boron