title: [Colorectal polyposis syndrome: a guide to diagnosis].
abstract: Biopsies and resection specimens of the gastrointestinal tract are a major part of the routine workload in many histopathology departments, whereby polypoid lesions are generally the main focus. In addition to distinguishing non-neoplastic from neoplastic polyps and evaluating the grade of dysplasia of the latter, the pathologist should always consider the possibility of an underlying polyposis syndrome. Not only have additional hereditary polyposis syndromes been identified in recent years due to a better understanding of their genetic and epigenetic alterations but also knowledge on well known polyposes has improved, leading to subtyping of various forms according to their different genotype. It is essential for the histopathologist to understand that the conventional histomorphology of individual polyps combined with information on the number and distribution of these lesions and clinical data can provide clues regarding a possible hereditary background. Therefore, the correct histological assessment of polyps is not just about getting the diagnosis right, it might also lead to genetic screening of family members and spouses.
authors.affiliation: Institut für Pathologie, Otto-von-Guericke-Universität Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Roessner
authors.forename: D
authors.initials: D
authors.lastname: Kuester
authors.forename: T
authors.initials: T
authors.lastname: Guenther
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000145:classification / Q000235:genetics / Q000473:pathology*; D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D003113:Colonoscopy; D003299:Cooperative Behavior; D045647:DNA Glycosylases / Q000235:genetics; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005820:Genetic Testing; D006801:Humans; D007223:Infant; D033183:Interdisciplinary Communication; D007413:Intestinal Mucosa / Q000473:pathology; D044483:Intestinal Polyposis / Q000151:congenital / Q000235:genetics / Q000473:pathology; D009386:Neoplastic Syndromes, Hereditary; D010348:Patient Care Team; D010580:Peutz-Jeghers Syndrome / Q000235:genetics / Q000473:pathology; D055815:Young Adult
chemical_list: C555337:APC protein, human; D025601:Adenomatous Polyposis Coli Protein; D045647:DNA Glycosylases; C061738:mutY adenine glycosylase