title: [Expression status of diabetes-associated genes in middle and aged cynomolgus monkeys].
abstract: A total of 138 middle and aged cynomolgus monkeys (Macaca fascicularis) (above 10 years) were classified into three groups based on fasting plasma glucose (FPG) values, specifically low FPG, normal FPG, and high FPG group. Total cholesterol (TCHO), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were detected in blood by automatic biochemical analyzer. The mRNA expressions of 37 diabetes-associated genes were analyzed with Real-time PCR in monocytes isolated from monkey peripheral blood. No significant correlation between the four serum lipid indictors HDL-C, LDL-C, TCHO, TG and FPG (P>0.05) were found. However, the expressions of ACE, ACLY, PRKCB1, SLC2A4, SNAP23, VAPA, IGF2BP2, and IFNG were significantly enhanced when FPG increased (P<0.05).
authors.affiliation: Guangdong Entomological Institute, Guangzhou 510260, China.
authors.forename: Xiu-Juan
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Xue-Jia
authors.initials: XJ
authors.lastname: Li
authors.forename: Ji-Liang
authors.initials: JL
authors.lastname: Xia
authors.forename: Sun-Xing
authors.initials: SX
authors.lastname: Yan
authors.forename: Fang
authors.initials: F
authors.lastname: Ji
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Zhang
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Liu
authors.forename: Bai-Lu
authors.initials: BL
authors.lastname: Peng
mesh_terms: D000367:Age Factors; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008252:Macaca fascicularis / Q000235:genetics / Q000378:metabolism; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides