title: Uniform zwitterionic polymer hydrogels with a nonfouling and functionalizable crosslinker using photopolymerization.
abstract: We reported previously the design and synthesis of a zwitterionic carboxybetaine dimethacrylate crosslinker, and we showed that its use with zwitterionic carboxybetaine methacrylate led to nonfouling hydrogels with high mechanical properties and high hydration. Now, we use photopolymerization to improve the uniformity of the polymer network, resulting in drastically improved mechanical properties (compressive modulus up to 90 MPa). Furthermore, we designed and synthesized a new functionalizable carboxybetaine dimethacrylate crosslinker, enabling functionalization of the higher strength hydrogels against a nonfouling background. Additionally, the biostability of the carboxybetaine hydrogel systems was tested, and it was found that these hydrogels are stable in oxidative, acidic, and basic environments.
authors.affiliation: Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
authors.forename: Louisa R
authors.initials: LR
authors.lastname: Carr
authors.forename: Yibo
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jordan E
authors.initials: JE
authors.lastname: Krause
authors.forename: Hong
authors.initials: H
authors.lastname: Xue
authors.forename: Shaoyi
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001622:Betaine / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D019556:COS Cells; D002522:Chlorocebus aethiops; D003432:Cross-Linking Reagents / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry*; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D015394:Molecular Structure; D010777:Photochemistry / Q000379:methods*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D013314:Stress, Mechanical; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020100:Hydrogels; D008689:Methacrylates; D011108:Polymers; D014867:Water; D001622:Betaine