title: One-step photochemical synthesis of permanent, nonleaching, ultrathin antimicrobial coatings for textiles and plastics.
abstract: Antimicrobial copolymers of hydrophobic N-alkyl and benzophenone containing polyethylenimines were synthesized from commercially available linear poly(2-ethyl-2-oxazoline), and covalently attached to surfaces of synthetic polymers, cotton, and modified silicon oxide using mild photo-cross-linking. Specifically, these polymers were applied to polypropylene, poly(vinyl chloride), polyethylene, cotton, and alkyl-coated oxide surfaces using solution casting or spray coating and then covalently cross-linked rendering permanent, nonleaching antimicrobial surfaces. The photochemical grafting of pendant benzophenones allows immobilization to any surface that contains a C-H bond. Incubating the modified materials with either Staphylococcus aureus or Escherichia coli demonstrated that the modified surfaces had substantial antimicrobial capacity against both Gram-positive and Gram-negative bacteria (>98% microbial death).
authors.affiliation: Department of Chemistry and Faculty of Engineering, University of Georgia , Athens, Georgia 30602, United States.
authors.forename: Vikram P
authors.initials: VP
authors.lastname: Dhende
authors.forename: Satyabrata
authors.initials: S
authors.lastname: Samanta
authors.forename: David M
authors.initials: DM
authors.lastname: Jones
authors.forename: Ian R
authors.initials: IR
authors.lastname: Hardin
authors.forename: Jason
authors.initials: J
authors.lastname: Locklin
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D055668:Photochemical Processes; D010969:Plastics / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011073:Polyamines / Q000737:chemistry; D011095:Polyethylenes / Q000737:chemistry; D011126:Polypropylenes / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties; D013784:Textiles / Q000633:toxicity; D014466:Ultraviolet Rays
chemical_list: D000890:Anti-Infective Agents; D001577:Benzophenones; D010969:Plastics; D011073:Polyamines; D011095:Polyethylenes; D011126:Polypropylenes; C511916:poly(2-ethyl-2-oxazoline); C047723:benzophenone; D011143:Polyvinyl Chloride