title: Calcium signaling in cognition and aging-dependent cognitive decline.
abstract: Calcium-dependent signals are key triggers of the molecular mechanisms underlying learning and memory and dysregulation of calcium homeostasis in the aging brain has been proposed to underlie aging-dependent cognitive decline. Mechanisms triggered by calcium in neurons include activity-dependent activation of transcription responsible for the synthesis of molecules underlying the long-term changes of neuronal function. Effectors of calcium signaling with a primordial role in transcription regulation are calcium signal-regulated transcription factors. In this review, we summarize the current knowledge of the contribution of key calcium signal-regulated transcription factors, namely CREB, NFAT, and DREAM, to memory formation. We further describe evidence for dysregulation of the activity of these factors during aging.
authors.affiliation: Department of Neurobiology, Interdisciplinary Centre for Neurosciences, University of Heidelberg, Germany.
authors.forename: Ana M M
authors.initials: AM
authors.lastname: Oliveira
authors.forename: Hilmar
authors.initials: H
authors.lastname: Bading
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological
chemical_list: D002118:Calcium