title: Bartonella henselae infection of prosthetic aortic valve associated with colitis.
abstract: The diagnosis of infective endocarditis can be difficult, particularly with atypical presentation and negative blood cultures. A 61-year-old man with a porcine aortic valve presented with fever, intermittent confusion, diarrhea, and fatigue. In the community clinic setting, a colonoscopy performed for anemia demonstrated colitis. Symptoms progressed for months; elicitation of a history of significant kitten exposure and the finding of an axillary lymph node prompted testing for Bartonella henselae antibodies. High titer antibodies by indirect immunofluorescence assay indicated chronic B. henselae infection. Surgical valve replacement followed by prolonged doxycycline and rifampin led to cure. This case illustrates the complexities of infective endocarditis and is the first description B. henselae endocarditis associated with colitis in an immunocompetent adult.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of California San Diego, La Jolla, California, USA.
authors.forename: Maile Young
authors.initials: MY
authors.lastname: Karris
authors.forename: Christine M
authors.initials: CM
authors.lastname: Litwin
authors.forename: Hong S
authors.initials: HS
authors.lastname: Dong
authors.forename: Joseph
authors.initials: J
authors.lastname: Vinetz
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D018416:Bartonella henselae / Q000276:immunology / Q000302:isolation & purification; D002372:Cat-Scratch Disease / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D002415:Cats; D003092:Colitis / Q000382:microbiology*; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000188:drug therapy; D006350:Heart Valve Prosthesis / Q000382:microbiology*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial