title: Oncologic outcomes in advanced laryngeal squamous cell carcinomas treated with different modalities in a single institution: a retrospective analysis of 65 cases.
abstract: BACKGROUND
  Treatment for laryngeal squamous cell carcinoma (SCC) has been predominantly surgical for decades, but in the last 20 years nonsurgical modalities (radiotherapy), with the aim of organ preservation, also became predominant among advanced stages. Retrospectively evaluating our series of stage III and stage IV laryngeal SCCs, we compared the 2 main therapeutic modalities.
  
  
  METHODS
  Medical records of 65 consecutive patients with advanced laryngeal SCC, from November 2005 to January 2009, were reviewed.
  
  
  RESULTS
  Among irradiated patients 2-year organ preservation was 86% for cT2, 43% for cT3, and 17% for cT4a (p = .037, Wilcoxon test). With respect to survival, the only significant differences between surgery and radiotherapy were detected among cT4a SCCs (p = .03, Wilcoxon test), in favor of surgery.
  
  
  CONCLUSIONS
  The present results confirm the surgical recommendation for cT4a laryngeal SCCs. On the other hand, for T < 4, our results confirm that radiochemotherapy warrants a survival similar to that of total laryngectomy, thus allowing us to preserve the larynx in a relevant number of cases.
authors.affiliation: Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy. francescobussu@yahoo.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Bussu
authors.forename: Francesco
authors.initials: F
authors.lastname: Miccichè
authors.forename: Mario
authors.initials: M
authors.lastname: Rigante
authors.forename: Nicola
authors.initials: N
authors.lastname: Dinapoli
authors.forename: Claudio
authors.initials: C
authors.lastname: Parrilla
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Bonomo
authors.forename: Gabriella
authors.initials: G
authors.lastname: Cadoni
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mantini
authors.forename: Jacopo
authors.initials: J
authors.lastname: Galli
authors.forename: Vittoria
authors.initials: V
authors.lastname: Rufini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Almadori
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Valentini
authors.forename: Gaetano
authors.initials: G
authors.lastname: Paludetti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D059248:Chemoradiotherapy / Q000379:methods*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D007825:Laryngectomy / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome