title: HYDRAmers: design, synthesis and characterization of different generation novel Hydra-like dendrons based on multifunctionalized adamantane.
abstract: In this communication we present a new synthetic strategy to different generation Hydra-like dendrons based on tetrafunctionalized adamantane as a building block. The novel dendrons, which we termed HYDRAmers, possess at the periphery and at the central core orthogonal protections that can be exploited for conjugation of targeting ligands, drugs and/or imaging probes.
authors.affiliation: CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 15 Rue René Descartes, 67084 Strasbourg, France. g.lamanna@ibmc-cnrs.unistra.fr
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lamanna
authors.forename: Julie
authors.initials: J
authors.lastname: Russier
authors.forename: Cécilia
authors.initials: C
authors.lastname: Ménard-Moyon
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D000818:Animals; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D015195:Drug Design; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice
chemical_list: D050091:Dendrimers; D007770:L-Lactate Dehydrogenase; D000218:Adamantane