title: Clinical practice guidelines for the management of patients with endometrial cancer in France: recommendations of the Institut National du Cancer and the Société Française d'Oncologie Gynécologique.
abstract: BACKGROUND
  Endometrial cancer is the most common gynecological malignancy in France, with more than 6500 new cases in 2010. The French National Cancer Institute has been leading a clinical practice guidelines (CPG) project since 2008. This project involves the development and updating of evidence-based CPG in oncology.
  
  
  OBJECTIVE
  To develop CPG for diagnosis, treatment, and follow-up for patients with endometrial cancer.
  
  
  METHODS
  The guideline development process is based on systematic literature review and critical appraisal by experts, with feedback from specialists in cancer care delivery. The recommendations are thus based on the best available evidence and expert agreement.
  
  
  RESULTS
  Main recommendations include a routine pelvic magnetic resonance imaging in association with magnetic resonance imaging exploration of the para-aortic lymph nodes for locoregional staging, surgical treatment based on total hysterectomy with bilateral salpingo-oophorectomy with or without lymphadenectomy, and clinical examination for the follow-up. The initial laparoscopic surgical approach is recommended for stage I tumors. Lymphadenectomy and postoperative external radiotherapy are recommended for patients with high risk of recurrence but are restricted for patients with low or intermediate risk. If brachytherapy is indicated, it should be given at a high-dose rate rather than a low-dose rate. Routine imaging, biologic tests, and vaginal smears are not indicated for follow-up.
authors.affiliation: Institut Claudius Regaud, Toulouse, France. querleu.denis@claudiusregaud.fr
authors.forename: Denis
authors.initials: D
authors.lastname: Querleu
authors.forename: François
authors.initials: F
authors.lastname: Planchamp
authors.forename: Fabrice
authors.initials: F
authors.lastname: Narducci
authors.forename: Philippe
authors.initials: P
authors.lastname: Morice
authors.forename: Florence
authors.initials: F
authors.lastname: Joly
authors.forename: Catherine
authors.initials: C
authors.lastname: Genestie
authors.forename: Christine
authors.initials: C
authors.lastname: Haie-Meder
authors.forename: Laurence
authors.initials: L
authors.lastname: Thomas
authors.forename: Nathalie
authors.initials: N
authors.lastname: Quénel-Tueux
authors.forename: Emile
authors.initials: E
authors.lastname: Daraï
authors.forename: Pierre-Hervé
authors.initials: PH
authors.lastname: Dorangeon
authors.forename: Henri
authors.initials: H
authors.lastname: Marret
authors.forename: Sophie
authors.initials: S
authors.lastname: Taïeb
authors.forename: Valérie
authors.initials: V
authors.lastname: Mazeau-Woynar
mesh_terms: D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006176:Gynecology / Q000331:legislation & jurisprudence / Q000379:methods / Q000639:trends; D006801:Humans; D009367:Neoplasm Staging / Q000379:methods; D018203:Sarcoma, Endometrial Stromal / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*