title: Biochemical parameters and anthropometry predict NAFLD in obese children.
abstract: The aim of the present study was to build a predictive model of nonalcoholic fatty liver disease (NAFLD) in obese children. Fifty-six obese 10-year-old children underwent blood tests for biochemical measures and magnetic resonance imaging for NAFLD diagnosis. A model combining waist-to-height ratio, homeostasis model assessment of insulin resistance, adiponectin, and alanine aminotransferase was accurate in predicting NAFLD (AUROC = 0.94 [95% confidence interval 0.89-0.99], P < 10). When adiponectin was not included in the model, the discrimination accuracy was still good (AUROC = 0.88 [95% confidence interval 0.79-0.97], P < 10). In conclusion, a predictive equation combining routinely available variables may allow physicians to identify obese children at the highest risk of NAFLD.
authors.affiliation: Unit of Pediatric Diabetes, Clinical Nutrition and Obesity, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Maffeis
authors.forename: Claudia
authors.initials: C
authors.lastname: Banzato
authors.forename: Francesca
authors.initials: F
authors.lastname: Rigotti
authors.forename: Valerio
authors.initials: V
authors.lastname: Nobili
authors.forename: Silvia
authors.initials: S
authors.lastname: Valandro
authors.forename: Riccardo
authors.initials: R
authors.lastname: Manfredi
authors.forename: Anita
authors.initials: A
authors.lastname: Morandi
mesh_terms: D052242:Adiponectin / Q000097:blood; D000410:Alanine Transaminase / Q000097:blood; D000886:Anthropometry; D001669:Biochemical Phenomena; D001823:Body Composition; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D005234:Fatty Liver / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D008954:Models, Biological; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D012307:Risk Factors; D044465:White People
chemical_list: D052242:Adiponectin; D000410:Alanine Transaminase