title: Repeated assessments of food security predict CD4 change in the setting of antiretroviral therapy.
abstract: Food insecurity is highly prevalent in HIV-infected populations, and analyses utilizing multiple assessments of food security to predict CD4 change are lacking. Five hundred Ninety-two patients with ≥ 4 food security assessments were followed prospectively. In the final model, for patients using antiretroviral therapy, increases in CD4 counts were on average 99.5 cells less for individuals with at least 1 episode of food insecurity compared with those consistently food secure (P < 0.001). Other sociodemographic factors were not predictive. Repeated assessments of food security are potent predictors of treatment response notwithstanding antiretroviral therapy use. Potential mechanisms for this association are proposed.
authors.affiliation: Department of Infectious Diseases, Alfred Hospital, Melbourne, Australia. ja.mcmahon@alfred.org.au
authors.forename: James H
authors.initials: JH
authors.lastname: McMahon
authors.forename: Christine A
authors.initials: CA
authors.lastname: Wanke
authors.forename: Julian H
authors.initials: JH
authors.lastname: Elliott
authors.forename: Sally
authors.initials: S
authors.lastname: Skinner
authors.forename: Alice M
authors.initials: AM
authors.lastname: Tang
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D005523:Food Supply / Q000191:economics / Q000706:statistics & numerical data*; D015658:HIV Infections / Q000188:drug therapy* / Q000191:economics; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011203:Poverty; D011446:Prospective Studies; D012307:Risk Factors; D015819:Substance Abuse, Intravenous
chemical_list: D019380:Anti-HIV Agents