title: Biological basis of exercise-based treatments for musculoskeletal conditions.
abstract: Exercise-based therapies are the cornerstone of rehabilitation programs. While the benefits of exercise on systemic and tissue function are generally accepted, mechanisms underlying these benefits are sometimes poorly understood. An improved understanding of the effects of mechanical loading on molecular and cellular processes has the potential to lead to more disease-specific and efficacious exercise-based therapies. The purpose of this paper is to review the current literature examining the role of mechanical signaling on muscle and cartilage biology.
authors.affiliation: Department of Physical Medicine and Rehabilitation, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. ambrosiof@upmc.edu
authors.forename: Fabrisia
authors.initials: F
authors.lastname: Ambrosio
authors.forename: Ayman
authors.initials: A
authors.lastname: Tarabishy
authors.forename: Fawzi
authors.initials: F
authors.lastname: Kadi
authors.forename: Elke H P
authors.initials: EH
authors.lastname: Brown
authors.forename: Gwendolyn
authors.initials: G
authors.lastname: Sowa
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D009140:Musculoskeletal Diseases / Q000378:metabolism / Q000534:rehabilitation*
chemical_list: D015415:Biomarkers