title: [Hepatoprotective effects of orally administered melatonin and tinospora cordifolia in experimental jaundice].
abstract: Posthepatic cholestasis is figured by the onset of an intense oxidative stress, followed by important cellular morphological and functional abnormalities. The aim of this experimental study is to assess the hepatoprotective effects of Melatonin and extract of Tinospora cordifolia in bile duct ligation induced jaundice in rats. We choosed to administrate both pharmacological products per os, in order to compare the results with those already published, in which melatonin was administrated injectable. The assessment of microscopy, lab tests and the measurement of oxidative stress products indicates a marked hepatoprotective effect of those two compounds. The results allowed us to recomand the use of melatonin and Tinospora cordifolia to reduce the cholestasis's oxidative stress in human.
authors.affiliation: Departamentul Chirurgie, Clinica Chirurgie 3, Universitatea de Medicină şi Farmacie Iuliu Hatieganu Cluj-Napoca, România. mariustanca@yahoo.com
authors.forename: M H
authors.initials: MH
authors.lastname: Stanca
authors.forename: A
authors.initials: A
authors.lastname: Nagy
authors.forename: M
authors.initials: M
authors.lastname: Toşa
authors.forename: L
authors.initials: L
authors.lastname: Vlad
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002779:Cholestasis / Q000150:complications; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D041781:Jaundice, Obstructive / Q000188:drug therapy* / Q000209:etiology; D008099:Liver / Q000187:drug effects; D008550:Melatonin / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D031610:Tinospora
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D008550:Melatonin