title: Duodenal ulcer disease, gastroduodenal motor function and reflux esophagitis--a cross-sectional survey in a subset of Taiwanese patients.
abstract: BACKGROUND
  To investigate the association between the gastric emptying rate and the presence of erosive esophagitis in duodenal ulcer (DU) patients among a population with high prevalence of Helicobacter pylori infection.
  
  
  METHODS
  Cross-sectional survey was performed in a cohort of 60 male patients with either active or healed DU, with or without the presence of erosive esophagitis. Clinical and social-demographic data, blood level of fasting gastrin, pepsinogen I & I/II ratio, and scintigraphic measurement of half emptying time (t(1/2) ) of the solid phase gastric emptying were evaluated.
  
  
  RESULTS
  Patients with active DU and erosive esophagitis tended to have higher plasma level of fasting gastrin than those without erosive esophagitis (75.11±13.74 vs 45.81±5.06pgmL(-1) , P = 0.059). In the absence of H. pylori infection, patients with healed DU and erosive esophagitis had a trend to have longer half-emptying time (t(1/2) : 96.5±6.4 vs 69.1±11.3min, P=0.0572) than those without erosive esophagitis, and statistically significant longer after excluding those diagnosed with hiatal hernia (t(1/2) : 100.8±7.9min vs 69.1±11.3min, P<0.05) from the former group. Among the healed DU patients, those with negative H. pylori infection, hiatal hernia and overweight (body mass index ≥24) had significantly increased risk of severe esophagitis.
  
  
  CONCLUSIONS
  Presence of erosive esophagitis in a subset of Taiwanese patients with healed DU and negative H. pylori status was associated with slower solid phase gastric emptying.
authors.affiliation: Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan. ycsu@kmu.edu.tw
authors.forename: Y-C
authors.initials: YC
authors.lastname: Su
authors.forename: Y-W
authors.initials: YW
authors.lastname: Chen
authors.forename: D-C
authors.initials: DC
authors.lastname: Wu
authors.forename: W-M
authors.initials: WM
authors.lastname: Wang
authors.forename: C-M
authors.initials: CM
authors.lastname: Jan
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004381:Duodenal Ulcer / Q000150:complications* / Q000382:microbiology; D004942:Esophagitis, Peptic / Q000209:etiology* / Q000503:physiopathology*; D005746:Gastric Emptying / Q000502:physiology*; D005755:Gastrins / Q000097:blood; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D013624:Taiwan
chemical_list: D005755:Gastrins