title: Obscured phylogeny and possible recombinational dormancy in Escherichia coli.
abstract: BACKGROUND
  Escherichia coli is one of the best studied organisms in all of biology, but its phylogenetic structure has been difficult to resolve with current data and analytical techniques. We analyzed single nucleotide polymorphisms in chromosomes of representative strains to reconstruct the topology of its emergence.
  
  
  RESULTS
  The phylogeny of E. coli varies according to the segment of chromosome analyzed. Recombination between extant E. coli groups is largely limited to only three intergroup pairings.
  
  
  CONCLUSIONS
  Segment-dependent phylogenies most likely are legacies of a complex recombination history. However, E. coli are now in an epoch in which they no longer broadly share DNA. Using the definition of species as organisms that freely exchange genetic material, this recombinational dormancy could reflect either the end of E. coli as a species, or herald the coalescence of E. coli groups into new species.
authors.affiliation: Department of Pediatrics, Washington University School of Medicine, Saint Louis, USA.
authors.forename: Shana R
authors.initials: SR
authors.lastname: Leopold
authors.forename: Stanley A
authors.initials: SA
authors.lastname: Sawyer
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Whittam
authors.forename: Phillip I
authors.initials: PI
authors.lastname: Tarr
mesh_terms: D004926:Escherichia coli / Q000145:classification* / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic