title: [Low-flow xenon anesthesia in surgical patients with hypertension].
abstract: A comparative study of central hemodynamics in 60 patients with essential hypertension during low flow anesthesia with xenon and nitrous oxide is carried out. The main group consisted of 30 patients, 22 male and 8 female, in the median age of 45.9 +/- 23 years. 22 patients out of those had 2nd stage essential hypertension, while the other 8 had 3rd stage. The control group consisted of 30 patients, 20 male and 10 female, in the median age of 45.1 + 1.3 years. 4 patients had 3rd stage essential hypertension, 26 patients had 2nd stage. The both groups were clinically comparable by the character and severity of the main disease, the carried out surgery (open cholecystectomy) and the qualification of surgeons. Results of the research showed, that low flow monoanesthesia with xenon abruptly eradicated the unfavourable consequences of induction of anesthesia (3-5 mg/kg of sodium thiopental or 2-2.5 mg/kg of propofol) and had a positive effect on the parameters of central hemodynamics of patients with essential hypertension. Xenon anesthesia, compared to nitrous oxide, rapidly stabilized the parameters of blood pressure and heart rate and can be recommended as a method of choice in patients with essential hypertension and compromised myocarium. Nitrous oxide with bolus of regular fentanyl doses doesn't reliable anesthesiological protection during open cholecystectomy and shows signs of toxicity.
authors.forename: A B
authors.initials: AB
authors.lastname: Rashchupkin
authors.forename: N E
authors.initials: NE
authors.lastname: Burov
mesh_terms: D000764:Anesthesia, Closed-Circuit / Q000379:methods*; D002763:Cholecystectomy / Q000379:methods; D041761:Cholecystolithiasis / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009609:Nitrous Oxide / Q000009:adverse effects; D012121:Respiration, Artificial; D012720:Severity of Illness Index; D014978:Xenon / Q000009:adverse effects
chemical_list: D014978:Xenon; D009609:Nitrous Oxide