title: ω-3 Fatty acids have no impact on serum lactate levels after major gastric cancer surgery.
abstract: BACKGROUND
  Preoperative and intraoperative nutrition support in patients undergoing major surgery results in decreased incidence of morbidity and mortality. Studies investigating the role of ω-3 fatty acids in these patients are increasing. Some are focused on perfusion at the cellular level. This study was undertaken to address the effect of postoperative administration of ω-3 fatty acids on cellular hypoperfusion associated with major gastric surgery.
  
  
  METHODS
  Twenty-six patients undergoing gastric cancer surgery were randomly assigned to receive parenteral nutrition (PN) supplemented with a combination of ω-6 and ω-3 fatty acids (Omegaven, 0.2 g/kg/d; Lipovenoes 10%, 0.6 g/kg/d) or with ω-6 fatty acid (Lipovenoes 10%, 0.8 g/kg/d) for 5 days. Blood samples were taken preoperatively, postoperative day 1, and on the last day of PN therapy (day 5).
  
  
  RESULTS
  Patients receiving ω-3 and ω-6 fatty acids showed neither lower serum lactate levels nor lower rates of complications compared with patients receiving ω-6 only. There were no statistically significant differences between the groups in other biochemical parameters, complications, or length of hospital stay or mortality.
  
  
  CONCLUSIONS
  PN with ω-3 fatty acid supplementation does not have a significant impact on cellular hypoperfusion and lactate clearance after major gastric surgery.
authors.affiliation: Department of General Surgery, Ege University, School of Medicine, Bornova-Izmir, Turkey. ozer.makay@ege.edu.tr
authors.forename: Ozer
authors.initials: O
authors.lastname: Makay
authors.forename: Tayfun
authors.initials: T
authors.lastname: Kaya
authors.forename: Ozgur
authors.initials: O
authors.lastname: Firat
authors.forename: Murat
authors.initials: M
authors.lastname: Sozbilen
authors.forename: Cemil
authors.initials: C
authors.lastname: Caliskan
authors.forename: Gulten
authors.initials: G
authors.lastname: Gezer
authors.forename: Mehmet
authors.initials: M
authors.lastname: Uyar
authors.forename: Sinan
authors.initials: S
authors.lastname: Ersin
mesh_terms: D013505:Digestive System Surgical Procedures; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015994:Incidence; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000379:methods; D011182:Postoperative Care; D011184:Postoperative Period; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000401:mortality* / Q000601:surgery*
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D019344:Lactic Acid