title: Unusually long survival of a 67-year-old patient with near-tetraploid acute myeloid leukemia m0 without erythroblastic and megakaryocytic dysplasia.
abstract: Patients with near-tetraploid acute myeloid leukemia (NT-AML) typically have poor survival. We present the case of a 67-year-old Caucasian male with NT-AML M0 who had an unusually long first complete remission of 51 months and an overall survival of 80 months. The only characteristic distinguishing him from other previously described patients with NT-AML was the absence of erythroblastic and/or megakaryocytic dysplasia (EMD) at diagnosis. Molecular-genetic testing for AML fusion transcripts associated with a favorable prognosis (PML/RARα,AML1/ETO, and CBFβ/MYH11) were negative, as were other prognostic markers like MLL-PTD,FLT3-ITD, or mutations of FLT3-D835,NPM1, or CEBPA. Expression studies of ERG,MN1, and EVI1 revealed overexpression of ERG only. The absence of EMD may be a useful prognostic/diagnostic feature of this new rare subtype of NT-AML.
authors.affiliation: Department of Hematology-Blood Transfusion, Hospital Jihlava, Jihlava, Czech Republic. plemez@post.cz
authors.forename: Petr
authors.initials: P
authors.lastname: Lemež
authors.forename: Hana
authors.initials: H
authors.lastname: Klamová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Zemanová
authors.forename: Iuri
authors.initials: I
authors.lastname: Marinov
authors.forename: Ota
authors.initials: O
authors.lastname: Fuchs
authors.forename: Jiří
authors.initials: J
authors.lastname: Schwarz
authors.forename: Jana
authors.initials: J
authors.lastname: Březinová
authors.forename: Dana
authors.initials: D
authors.lastname: Provazníková
authors.forename: Arnošt
authors.initials: A
authors.lastname: Kostečka
authors.forename: Jana
authors.initials: J
authors.lastname: Marková
authors.forename: Kyra
authors.initials: K
authors.lastname: Michalová
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Jelínek
mesh_terms: D000368:Aged; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D000090243:Nucleophosmin; D012074:Remission Induction; D016019:Survival Analysis