title: [Impaired mitogen-induced lymphocyte transformation in patients with Yusho].
abstract: To investigate chronic immune effects of polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF), in vitro lymphocyte transformation in response to phytohemagglutinin (PHA) and concanavalin A (Con A) was studied in 139 patients with Yusho and 61 controls. PHA-induced lymphocyte transformation was significantly lower in patients with Yusho than in controls. PHA-induced lymphocyte transformation was inversely correlated with the concentrations of PCB and 2,3,4,7, 8-pentachlorodibenzofuran (PeCDF) in the blood. Con A-induced lymphocyte transformation showed similar inverse correlations with the concentrations of PCB and 2,3,4,7, 8-PeCDF. We conclude that impairment of mitogen-induced lymphocyte transformation in patients with Yusho may be associated with PCB and 2,3,4,7,8-PeCDF in the blood.
authors.affiliation: Department of Internal Medicine, Kitakyushu-Tsuyazaki Hospital, Fukuoka 811-3307, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsuji
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ito
mesh_terms: D001572:Benzofurans / Q000097:blood / Q000494:pharmacology*; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants / Q000097:blood / Q000494:pharmacology*; D005506:Food Contamination; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008934:Mitogens; D012275:Oryza / Q000506:poisoning*; D010938:Plant Oils / Q000506:poisoning*; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000494:pharmacology*
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D008934:Mitogens; D010938:Plant Oils; D011078:Polychlorinated Biphenyls