title: Chiral N-heterocyclic carbene catalyzed annulation of α,β-unsaturated aldehydes with 1,3-dicarbonyls.
abstract: Chiral N-heterocyclic carbene catalyzed annulations of ynals and enals with 1,3-dicarbonyls have been described. The two reactions provided direct and efficient methods for enantioselective synthesis of functionalized dihydropyranones. Comparatively, the reactions starting from ynals were atom-economical; furthermore the reactions of enals demonstrated broader substrate compatibility.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Zhu
authors.forename: Xing-Liang
authors.initials: XL
authors.lastname: Zheng
authors.forename: Ning-Fei
authors.initials: NF
authors.lastname: Jiang
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Wan
authors.forename: Ji-Chang
authors.initials: JC
authors.lastname: Xiao