title: Opitz trigonocephaly syndrome presenting with sudden unexplained death in the operating room: a case report.
abstract: BACKGROUND
  Opitz trigonocephaly C syndrome (OTCS) is a rare malformation syndrome with the following features: synostosis of metopic suture, craniofacial abnormalities, severe mental retardation and a multitude of pathological findings affecting almost every organ system. OTCS is associated with a high mortality rate.
  
  
  METHODS
  We describe the case of a Caucasian male baby who died at five months of age during surgical correction of the craniofacial anomaly.
  
  
  CONCLUSIONS
  As previously reported, OTCS may have an increased mortality rate during craniofacial surgery. Careful evaluation of surgery risk-benefit ratio is warranted in such patients.
authors.affiliation: Neonatal Intensive Care Unit, Institute for Maternal and Child Health Burlo Garofolo, Via dell'Istria 65/1, 34100, Trieste, Italy. ltravan@yahoo.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Travan
authors.forename: Vanna
authors.initials: V
authors.lastname: Pecile
authors.forename: Mariacristina
authors.initials: M
authors.lastname: Fertz
authors.forename: Antonella
authors.initials: A
authors.lastname: Fabretto
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Brovedani
authors.forename: Sergio
authors.initials: S
authors.lastname: Demarini
authors.forename: John M
authors.initials: JM
authors.lastname: Opitz