title: Use of an automated ACTH assay for the diagnosis of pituitary and adrenal-related diseases.
abstract: OBJECTIVE
  To evaluate Liaison Diasorin's automated ACTH assay.
  
  
  METHODS
  We investigated the limit of quantification (LOQ) and simulated the usage of the analyzer using our ACTH results database.
  
  
  RESULTS
  The LOQ was close to the cut-off determining Cushing's syndrome ACTH dependency. 25% concentrations of normal subjects were lower than the LOQ. Although biased, the results were concordant with those of an IRMA assay.
  
  
  CONCLUSIONS
  This assay is not sensitive enough to diagnose ACTH-independent Cushing's syndrome.
authors.affiliation: Department of Nuclear Medicine, University Hospital, Bordeaux, France.
authors.forename: J
authors.initials: J
authors.lastname: Brossaud
authors.affiliation: Department of Nuclear Medicine, University Hospital, Bordeaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Bouton
authors.affiliation: Department of Endocrinology, University Hospital, Bordeaux, France.
authors.forename: B
authors.initials: B
authors.lastname: Gatta
authors.affiliation: Department of Endocrinology, University Hospital, Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Tabarin
authors.affiliation: Department of Nuclear Medicine, University Hospital, Bordeaux, France. Electronic address: jean-benoit.corcuff@u-bordeaux2.fr.
authors.forename: J-B
authors.initials: JB
authors.lastname: Corcuff
mesh_terms: D000307:Adrenal Gland Diseases / Q000175:diagnosis*; D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D003480:Cushing Syndrome / Q000175:diagnosis; D019937:Diagnostic Techniques and Procedures / Q000592:standards*; D006801:Humans; D057230:Limit of Detection; D010900:Pituitary Diseases / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D000324:Adrenocorticotropic Hormone