title: Photolon enhancement of ultrasound cytotoxicity.
abstract: OBJECTIVE
  To evaluate the impact of Photolon on cytostatic and cytotoxic effects of therapeutic range ultrasound in C6 glioma cells.
  
  
  METHODS
  C6 glioma cells in suspension or monolayer cell culture were exposed to ultrasound (880 kHz, 0.2-0.7 W/cm2) in the presence or absence of Photolon at the concentration of 1 μg/ml in the culture medium, and then cell viability was evaluated.
  
  
  RESULTS
  Photolon increased the cytotoxic effect of ultrasound by 1.5-2.3-fold but had no effect on its cytostatic activity.
  
  
  CONCLUSIONS
  Photolon produces a pronounced sonosensitizing effect on glioma C6 cells and is a promising drug for sonodynamic treatment of malignant tumors.
authors.affiliation: N.N. Alexandrov National Cancer Center of Belarus, 223040 Minsk, Belarus.
authors.forename: D A
authors.initials: DA
authors.lastname: Tserkovsky
authors.forename: E N
authors.initials: EN
authors.lastname: Alexandrova
authors.forename: Yu P
authors.initials: YP
authors.lastname: Istomin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D002470:Cell Survival; D002735:Chlorophyllides; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D011166:Porphyrins; D011205:Povidone / Q000494:pharmacology*; D011524:Protoporphyrins / Q000494:pharmacology*; D051381:Rats; D014407:Tumor Cells, Cultured; D014464:Ultrasonic Therapy
chemical_list: D000970:Antineoplastic Agents; D002735:Chlorophyllides; D011166:Porphyrins; D011524:Protoporphyrins; C062985:phytochlorin; D011205:Povidone