title: [Ocular Lyme disease occurring during childhood: five case reports].
abstract: BACKGROUND
  Lyme borreliosis (LB) is the most common human tick-borne disease in the Northern hemisphere. The various ophthalmologic manifestations of Lyme borreliosis (LB) during childhood are discussed in this paper.
  
  
  METHODS
  Six children with LB-associated ocular manifestations were treated between 2000 and 2010 in the ophthalmology department of Strasbourg University Hospital (an endemic area). Medical history, ocular and systemic clinical findings, determinations of antibodies related to Borrelia, as well as exclusion of other causes were the diagnosis criteria.
  
  
  RESULTS
  Two cases of uveitis, two cases of abducens palsies, one case of optical neuropathy, and one case of orbital myositis associated with LB were diagnosed. Systemic findings, such as arthritis, rash, or erythema migrans were mentioned in all cases. Two children also complained of severe knee arthritis. Determination of antibodies was positive in all patients. They were all treated with antibiotics adjusted to individual circumstances and some of them (two cases of uveitis and one of optic neuropathy) also had anti-inflammatory treatment. Resolution of ocular signs, with no relapse, was observed in all patients within two to 12 weeks.
  
  
  CONCLUSIONS
  For any unexplained ocular symptom, even in children, LB should be taken into account, especially in endemic areas. Such patients should undergo serological testing. If the clinical presentation is suggestive of LB, a course of oral antibiotics should be used. All in all, permanent defects are extremely rare during the childhood period, even following long-term manifestation at an early age.
authors.affiliation: Service d'Ophtalmologie, Nouvel Hôpital Civil, CHU de Strasbourg, BP 426, 67091 Strasbourg cedex, France. arnaud.sauer@chru-strasbourg.fr
authors.forename: A
authors.initials: A
authors.lastname: Sauer
authors.forename: Y
authors.initials: Y
authors.lastname: Hansmann
authors.forename: B
authors.initials: B
authors.lastname: Jaulhac
authors.forename: T
authors.initials: T
authors.lastname: Bourcier
authors.forename: C
authors.initials: C
authors.lastname: Speeg-Schatz
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001898:Borrelia / Q000502:physiology; D002443:Ceftriaxone / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D004318:Doxycycline / Q000008:administration & dosage; D015818:Eye Infections, Bacterial / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D008193:Lyme Disease / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D004318:Doxycycline