title: Improved lipid profile in ovariectomized rats by red ginseng extract.
abstract: The effects of red ginseng extract on lipid metabolism were examined in ovariectomized rats. Twenty-four female Sprague-Dawley rats (210 +/- 20 g) were studied for 10 weeks. The rats were divided into four groups: (I) "sham" non-ovariectomized rats treated with olive oil, (II) control ovariectomized rats treated with olive oil, (III) ovariectomized rats treated with 0.5 mg/kg 17beta-estradiol in olive oil, and (IV) ovariectomized rats treated with 5mg/kg red ginseng extract in olive oil. Red ginseng extract induced significant reductions in total cholesterol, low density lipoprotein cholesterol/total cholesterol, high density lipoprotein cholesterol/total cholesterol, and low density lipoprotein cholesterol/high density lipoprotein cholesterol, implying the effectiveness of ginseng in targeting postmenopausal symptoms.
authors.affiliation: Department of Bioscience and Biotechnologyl, Institute of Biotechnology, College of Life Science, Sejong University, Seoul, Korea.
authors.forename: Yeomyeong
authors.initials: Y
authors.lastname: Park
authors.forename: Hyeok-Yi
authors.initials: HY
authors.lastname: Kwon
authors.forename: Myeong Kuk
authors.initials: MK
authors.lastname: Shimi
authors.forename: Mee-ra
authors.initials: MR
authors.lastname: Rhyu
authors.forename: YoungJoo
authors.initials: Y
authors.lastname: Lee
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002460:Cell Line; D005260:Female; D036145:Ginsenosides / Q000494:pharmacology; D006801:Humans; D000960:Hypolipidemic Agents; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008156:Luciferases / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology; D010957:Plasmids / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects; D014162:Transfection; D014599:Uterus / Q000187:drug effects
chemical_list: D036145:Ginsenosides; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D011960:Receptors, Estrogen; D008156:Luciferases