title: [Expression of Ki-67, p53, bcl-2, estrogen receptors alpha in patients with clear cell renal carcinoma and epidermal growth factor receptor mutation].
abstract: Three hundred and thirty-six cases of clear-cell renal carcinoma (CCRC) were examined for epidermal growth factor receptor (EGFR) mutation: exon 19 deletion and L858R mutation in exon 21 of the EGFR gene. The expression of Ki-67, bcl-2, p53, and estrogen receptors alpha was studied in CCRC with EGFR mutation. There were 4 cases of CCRC with EGFR exon 19 deletion. The frequency of EGFR gene mutations was 1.2%. L858R missense mutations in exon 21 of the EGFR gene were absent. In CCRC, EGFR gene mutation (exon 19 deletion) was detected in 3 men and 1 woman with an age range of 50 to 60 years and Fuhrman differentiation grade 2 or 3. The Ki-67 index varied from 4 to 23%. The expression of bcl-2 and p53 was negative. A moderate estrogen receptor alpha expression was revealed in 1 of 4 cases.
authors.forename: A O
authors.initials: AO
authors.lastname: Ivantsov
authors.forename: E N
authors.initials: EN
authors.lastname: Imianitov
authors.forename: V M
authors.initials: VM
authors.lastname: Moiseenko
authors.forename: D E
authors.initials: DE
authors.lastname: Matsko
authors.forename: A S
authors.initials: AS
authors.lastname: Artem'eva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics; D005091:Exons; D005260:Female; D015870:Gene Expression; D019254:Genes, bcl-2 / Q000235:genetics; D018773:Genes, erbB-1 / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D019394:Ki-67 Antigen / Q000235:genetics; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D017384:Sequence Deletion; D055815:Young Adult
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D019394:Ki-67 Antigen