title: An easy entry into 2-halo-3-aryl-4(3H)-quinazoliniminium halides from heteroenyne-allenes.
abstract: An efficient three-step synthesis of 2-halo-3-aryl-4(3H)-quinazoliniminium halides from commercially available materials is described. Upon reaction with hydrogen halides, generated in situ from a Lewis acid (MX) and trace water, a variety of easily accessible heteroenyne-allenes underwent facile intramolecular cyclization to afford the title compounds in good yields. The method is highly versatile and provides a general way to construct quinazoliniminium ring systems with a variety of different substitutions.
authors.affiliation: Department of Chemistry, Kansas State University, 213 CBC Building, Manhattan, Kansas 66506-0401, USA.
authors.forename: Vijaya Kumar
authors.initials: VK
authors.lastname: Naganaboina
authors.forename: Kusum Lata
authors.initials: KL
authors.lastname: Chandra
authors.forename: John
authors.initials: J
authors.lastname: Desper
authors.forename: Sundeep
authors.initials: S
authors.lastname: Rayat
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000466:Alkadienes; D006846:Hydrocarbons, Halogenated; D011799:Quinazolines; C025947:propadiene