title: Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice.
abstract: We investigated the effects of the second generation antipsychotics olanzapine, sertindole and clozapine on visual recognition memory using the novel object recognition (NOR) test in naive and MK-801-treated animals. The effects of drug treatment on locomotion and anxiety were also determined using the open field test. Male Balb-c mice were treated with olanzapine (0.2, 0.4 and 0.6 mg/kg; i.p.), sertindole (0.63, 1.3 and 2.5mg/kg; s.c.) or clozapine (0.5 and 1mg/kg; i.p.), and cognitive deficits were induced by MK-801 (0.2mg/kg; i.p.) administration. Olanzapine treatment decreased the ratio index in the NOR test, whereas sertindole and clozapine had no effect in naive mice. MK-801-induced cognitive impairment was reversed by treatment with olanzapine, sertindole or clozapine. While olanzapine, sertindole and clozapine had no effect on the anxiety of naive mice as determined by the open field test, MK-801 significantly increased the total distance traveled, time spent in the center zone and the velocity of the animals. MK-801-induced effects on locomotion and anxiety in the open field test were reversed by olanzapine, sertindole or clozapine treatment. The results of the present study demonstrated that olanzapine, sertindole and clozapine improved cognition in MK-801 treated mice, and indicate that these drugs have a potential to improve cognition in schizophrenia.
authors.affiliation: Kocaeli University Medical Faculty, Pharmacology Department, 41380-Kocaeli, Turkey. oguzmutlu80@hotmail.com
authors.forename: Oguz
authors.initials: O
authors.lastname: Mutlu
authors.forename: Güner
authors.initials: G
authors.lastname: Ulak
authors.forename: Ipek Komsuoglu
authors.initials: IK
authors.lastname: Celikyurt
authors.forename: Füruzan Yildiz
authors.initials: FY
authors.lastname: Akar
authors.forename: Faruk
authors.initials: F
authors.lastname: Erden
authors.forename: Pelin
authors.initials: P
authors.lastname: Tanyeri
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D018691:Excitatory Amino Acid Antagonists; D007093:Imidazoles / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects; D000077152:Olanzapine; D021641:Recognition, Psychology / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D018691:Excitatory Amino Acid Antagonists; D007093:Imidazoles; D007211:Indoles; D001569:Benzodiazepines; D016291:Dizocilpine Maleate; C066304:sertindole; D003024:Clozapine; D000077152:Olanzapine