title: Novel biomarkers in human terminal heart failure and under mechanical circulatory support.
abstract: This review summarizes recent findings on novel biochemical plasma biomarkers in terminal heart failure patients, which might predict an advanced mortality risk or even recovery. Moreover, we discussed the regulation of these heart failure-related biomarkers under mechanical circulatory support.
authors.affiliation: Bayer HealthCare AG, Global Biomarker Research, Pharma Research Center, Wuppertal, Germany. frank.kramer@bayer.com
authors.forename: Frank
authors.initials: F
authors.lastname: Kramer
authors.forename: Hendrik
authors.initials: H
authors.lastname: Milting
mesh_terms: D015415:Biomarkers / Q000097:blood*; D037502:Galectin 3 / Q000097:blood; D055436:Growth Differentiation Factor 15 / Q000097:blood; D055428:Growth Differentiation Factor 5 / Q000097:blood; D006333:Heart Failure / Q000097:blood*; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011956:Receptors, Cell Surface / Q000097:blood; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D019714:Tissue Inhibitor of Metalloproteinases / Q000097:blood; D000097792:Tissue Inhibitor of Metalloproteinase-4
chemical_list: D015415:Biomarkers; D037502:Galectin 3; D055436:Growth Differentiation Factor 15; D055428:Growth Differentiation Factor 5; D000072179:Interleukin-1 Receptor-Like 1 Protein; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D020097:Natriuretic Peptide, Brain; D011956:Receptors, Cell Surface; D019715:Tissue Inhibitor of Metalloproteinase-1; D019714:Tissue Inhibitor of Metalloproteinases; D000097792:Tissue Inhibitor of Metalloproteinase-4; C526140:GDF15 protein, human; C525893:GDF5 protein, human; C079241:IL1RL1 protein, human; C560822:TIMP1 protein, human