title: [Role of miR-145 in erectile dysfunction in diabetic rats].
abstract: OBJECTIVE
  To investigate the role of miR-145 in the corpus cavernosum smooth muscle tissue in the pathogenesis of erectile dysfunction (ED) in diabetic rats.
  
  
  METHODS
  The total RNA was extracted from the corpus cavernosum of a diabetic rat model with ED, diabetic rats with normal erectile function and normal rats, and the expression levels of miR145 were compared between the groups.
  
  
  RESULTS
  The expression of miR-145 was decreased in the corpus cavernosum of diabetic rats with ED.
  
  
  CONCLUSIONS
  Diabetes mellitus can cause ED in rats, in which process decreased expression of miR145 in the corpus cavernosum may play a role.
authors.affiliation: Division of Urinary Surgery, Huiqiao Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. profway@126.com
authors.forename: An-yang
authors.initials: AY
authors.lastname: Wei
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Shu-hua
authors.initials: SH
authors.lastname: He
authors.forename: Xin-gui
authors.initials: XG
authors.lastname: Luo
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D007172:Erectile Dysfunction / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009130:Muscle, Smooth / Q000378:metabolism; D010410:Penile Erection; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C542511:MIRN145 microRNA, rat; D035683:MicroRNAs