title: Post-translational modification of NMDA receptor GluN2B subunit and its roles in chronic pain and memory.
abstract: N-methyl-d-aspartate receptors (NMDA receptors) play critical roles in brain functions and diseases. The expression, trafficking, synaptic location and function of different NMDA receptor subtypes are not static, but regulated dynamically in a cell-specific and synapse-specific manner during physiological and pathological conditions. In this review, we will examine recent evidence on the post-translational modulation of NMDA receptors subunit, in particular GluN2B subunit, such as phosphorylation, palmitoylation, and ubiquitination. In parallel, we will overview the roles of these modifications of GluN2B-NMDA receptor subtype in physiological functions, such as learning and memory, and pathophysiological conditions, such as chronic pain, ischemia and neurodegenerative diseases.
authors.affiliation: Department of Physiology, Faculty of Medicine, The Centre for the Study of Pain, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.
authors.forename: Shuang
authors.initials: S
authors.lastname: Qiu
authors.forename: Xiang-Yao
authors.initials: XY
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Zhuo
mesh_terms: D059350:Chronic Pain / Q000503:physiopathology*; D006801:Humans; D054878:Lipoylation; D008568:Memory / Q000502:physiology*; D019636:Neurodegenerative Diseases; D009473:Neuronal Plasticity / Q000502:physiology*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000737:chemistry* / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: C121001:NR2B NMDA receptor; D021122:Protein Subunits; D016194:Receptors, N-Methyl-D-Aspartate