title: NIR spectroscopic imaging to map hemoglobin + myoglobin oxygenation, their concentration and optical pathlength across a beating pig heart during surgery.
abstract: The purpose of this paper is to demonstrate that near-infrared (NIR) spectroscopic imaging can provide spatial distribution (maps) of the absolute concentration of hemoglobin + myoglobin, oxygen saturation parameter and optical pathlength, reporting on the biochemico-physiological status of a beating heart in vivo. The method is based on processing the NIR spectroscopic images employing a first-derivative approach. Blood-pressure-controlled gating compensated the effect of heart motion on the imaging. All the maps are available simultaneously and noninvasively at a spatial resolution in the submillimeter range and can be obtained in a couple of minutes. The equipment has no mechanical contact with the tissue, thereby leaving the heart unaffected during the measurement.
authors.affiliation: National Research Council Institute for Biodiagnostics, 435 Ellice Ave., Winnipeg, Manitoba, Canada R3B 1Y6. gussak@gmail.com
authors.forename: Eugene
authors.initials: E
authors.lastname: Gussakovsky
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Yang
authors.forename: John
authors.initials: J
authors.lastname: Rendell
authors.forename: Olga
authors.initials: O
authors.lastname: Jilkina
authors.forename: Valery
authors.initials: V
authors.lastname: Kupriyanov
mesh_terms: D000818:Animals; D001794:Blood Pressure; D006321:Heart / Q000502:physiology; D006352:Heart Ventricles; D006454:Hemoglobins / Q000737:chemistry*; D008027:Light; D015233:Models, Statistical; D008962:Models, Theoretical; D009206:Myocardium / Q000166:cytology; D009211:Myoglobin / Q000737:chemistry*; D055095:Optics and Photonics; D010100:Oxygen / Q000737:chemistry; D012542:Scattering, Radiation; D013053:Spectrophotometry / Q000379:methods; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013314:Stress, Mechanical; D013552:Swine
chemical_list: D006454:Hemoglobins; D009211:Myoglobin; D010100:Oxygen