title: Cellular resolution optical coherence microscopy with high acquisition speed for in-vivo human skin volumetric imaging.
abstract: In this Letter, we report for the first time (to our knowledge) in-vivo volumetric optical coherence microscopy images of skin epidermal cells. We achieved micrometer-class resolution, 2 μm laterally and axially, with an acquisition speed of 23 K A-scans/s and over 90 dB sensitivity to a depth of 1 mm by employing a custom, liquid-lens-based, dynamic-focusing objective, a broadband light source, and a custom, astigmatism-corrected Czerny-Turner spectrometer with a high-speed complementary metal-oxide-semiconductor camera.
authors.affiliation: The Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York 14627, USA. kyelee@optics.rochester.edu
authors.forename: Kye-Sung
authors.initials: KS
authors.lastname: Lee
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Thompson
authors.forename: Panomsak
authors.initials: P
authors.lastname: Meemon
authors.forename: Jannick P
authors.initials: JP
authors.lastname: Rolland
mesh_terms: D000078404:Epidermal Cells; D006801:Humans; D008853:Microscopy / Q000379:methods*; D012867:Skin / Q000166:cytology*; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*