title: [Effect of traditional Chinese medicine injections on type I allergy].
abstract: OBJECTIVE
  To investigate allergic reactions of traditional Chinese medicine (TCM) injections, and to determine the contents of serum IgE and histamine in sensitized animal. The correlation between the preceding contents in serum and allergic reactions may be found, thus offering experimental evidences for advancing the accuracy of anticipation by type I allergy.
  
  
  METHODS
  We carried out passive cutaneous anaphylaxis (PCA) tests,active systemic anaphylaxis (ASA) tests and anaphylactoid reactions using three TCM injections, and determined the contents of serum OVA-sIgE, total serum IgE and histamine in sensitized animals by ELISA method.
  
  
  RESULTS
  The results of PCA test were negative, and there was no significant difference for total serum IgE level between experimental group and normal saline group. In the study of adjuvant effect in TCM injections + OVA (at the dose level that doesn't cause allergic reactions), the PCA results of SHL and YXC were positive and there was a increase in content of serum OVA-sIgE, while the PCA result of QKL was negative with a unobvious increase in the content of serum OVA-sIgE. The content of total serum IgE wasn't remarkably increased in each group and the results of ASA test were all positive. Three injections all caused anaphylactoid symptoms in guinea pigs in different doses or injection speed and the response intensity was found to be dosage and injection speed dependant. Furthermore, there was no significant difference for the content of total serum IgE in each group, whereas serum histamine concentration in every experimental group was markedly higher than normal saline group.
  
  
  CONCLUSIONS
  SHL and YXC increase the sensitivity of guinea pigs on OVA, and three TCM injections can cause allergic reactions in guinea pig. Allergic reactions of three TCM injections are correlated with specific IgE antibodies and histamine contents.
authors.affiliation: Chongqing Academy of Chinese Materia Meadica, Chongqing 400065, China. hcg2091@tom.com
authors.forename: Chonggang
authors.initials: C
authors.lastname: Huang
authors.forename: Xianqin
authors.initials: X
authors.lastname: Luo
authors.forename: Henghua
authors.initials: H
authors.lastname: Li
authors.forename: Jianyi
authors.initials: J
authors.lastname: Liu
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Mei
authors.forename: Jiahong
authors.initials: J
authors.lastname: Xu
mesh_terms: D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000097:blood; D006967:Hypersensitivity / Q000188:drug therapy*; D007073:Immunoglobulin E / Q000097:blood; D007267:Injections; D008297:Male; D008516:Medicine, Chinese Traditional; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects
chemical_list: D007073:Immunoglobulin E; D006632:Histamine; D010047:Ovalbumin