title: Intra-arterial nimodipine infusion for cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
abstract: This study evaluated the efficacy of intra-arterial nimodipine infusion for symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). Clinical data collected from 42 consecutive patients with symptomatic vasospasm after aSAH were retrospectively reviewed. Forty-two patients underwent 101 sessions of intra-arterial nimodipine infusion. Angiographic response, immediate clinical response, and clinical outcome were evaluated at discharge and six months later. Angiographic improvement was achieved in 82.2% of patients. The immediate clinical improvement rate was 68.3%, while the deterioration rate was 5.0%. A favorable clinical outcome was achieved in 76.2% at discharge and 84.6% six months. Vasospasm-related infarction occurred in 21.4%. There was no drug-related complication. The nimodipine group showed satisfactory outcomes. Nimodipine can be recommended as an effective and safe intra-arterial agent for the treatment of symptomatic vasospasm after aSAH.
authors.affiliation: Department of Neurosurgery, Kangwon National University Hospital, School of Medicine, Chuncheon, Gangwon-do, Korea.
authors.forename: W-S
authors.initials: WS
authors.lastname: Cho
authors.forename: H-S
authors.initials: HS
authors.lastname: Kang
authors.forename: J E
authors.initials: JE
authors.lastname: Kim
authors.forename: O-K
authors.initials: OK
authors.lastname: Kwon
authors.forename: C W
authors.initials: CW
authors.lastname: Oh
authors.forename: Y J
authors.initials: YJ
authors.lastname: Son
authors.forename: B J
authors.initials: BJ
authors.lastname: Know
authors.forename: C
authors.initials: C
authors.lastname: Jung
authors.forename: M H
authors.initials: MH
authors.lastname: Hang
mesh_terms: D000328:Adult; D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000009:adverse effects; D002533:Cerebral Angiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000008:administration & dosage* / Q000009:adverse effects; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D016896:Treatment Outcome; D020301:Vasospasm, Intracranial / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology
chemical_list: D002121:Calcium Channel Blockers; D009553:Nimodipine