title: Pro-senescence therapy for cancer treatment.
abstract: Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.
authors.affiliation: Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA.
authors.forename: Caterina
authors.initials: C
authors.lastname: Nardella
authors.forename: John G
authors.initials: JG
authors.lastname: Clohessy
authors.forename: Andrea
authors.initials: A
authors.lastname: Alimonti
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Pandolfi
mesh_terms: D002453:Cell Cycle; D016922:Cellular Senescence; D016259:Genes, myc; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D014411:Neoplastic Stem Cells / Q000473:pathology; D051059:PTEN Phosphohydrolase / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
chemical_list: D016159:Tumor Suppressor Protein p53; D051059:PTEN Phosphohydrolase