title: [Analysis of sevoflurane stability during low flow anesthesia].
abstract: Using the mass spectrometric method we studied the interaction of volatile anesthetic sevoflurane with a CO2 absorber during low flow anesthesia (0.5 l/min fresh gas mixture). The results of measurements of sevoflurane and one of the most toxic breakdown products of sevoflurane CF = C(CF3)-O-CH2F (substance A) throughout the anesthesia in the mode of inhalation-exhalation. The highest recorded concentration of substance A was 65 ppm. Biochemical analysis of blood before and after anesthesia did not show connection with nephropathy and function of liver toxicity.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Elizarov
authors.forename: T D
authors.initials: TD
authors.lastname: Ershov
authors.forename: A I
authors.initials: AI
authors.lastname: Levshankov
mesh_terms: D000764:Anesthesia, Closed-Circuit; D018685:Anesthetics, Inhalation / Q000009:adverse effects / Q000097:blood* / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry; D004355:Drug Stability; D004987:Ethers / Q000097:blood*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000097:blood*; D007668:Kidney / Q000187:drug effects; D007677:Kidney Function Tests; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D013058:Mass Spectrometry; D008738:Methyl Ethers / Q000009:adverse effects / Q000097:blood* / Q000737:chemistry; D016343:Monitoring, Intraoperative; D010087:Oxides / Q000737:chemistry; D000077149:Sevoflurane; D012972:Sodium Hydroxide / Q000737:chemistry
chemical_list: D018685:Anesthetics, Inhalation; D017610:Calcium Compounds; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D008738:Methyl Ethers; D010087:Oxides; D000077149:Sevoflurane; C004569:soda lime; D012972:Sodium Hydroxide; C078742:fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether