title: Metalloproteinases in idiopathic pulmonary fibrosis.
abstract: In this article, we outline the current state of knowledge about the balance between collagen production and degradation in idiopathic pulmonary fibrosis (IPF). The dysregulated action of metalloproteinases implicated in IPF may play a central role in IPF pathogenesis. Inhibiting metalloproteinases in IPF may, therefore, have therapeutic potential, but our knowledge of their pathophysiological role is held back by limited animal models and the lack of specific inhibitors.
authors.affiliation: Respiratory Medicine, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.
authors.forename: R C A
authors.initials: RC
authors.lastname: Dancer
authors.forename: A M
authors.initials: AM
authors.lastname: Wood
authors.forename: D R
authors.initials: DR
authors.lastname: Thickett
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000188:drug therapy / Q000378:metabolism*; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D051381:Rats
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D003094:Collagen; D020782:Matrix Metalloproteinases