title: Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ 1-42 oligomer injection.
abstract: Soluble oligomeric forms of amyloid beta (AβO) are regarded as a main cause of synaptic and cognitive dysfunction in Alzheimer's disease (AD) and have been a primary target in the development of drug treatments for AD. The present study utilized a mouse model of AD induced by intrahippocampal injection of AβO (10 μM) to investigate the effects of Gami-Chunghyuldan (GCD), a standardized multi-herbal medicinal formula, on the presentation of memory deficits and neurohistological pathogenesis. GCD (10 and 50mg/kg/day, 5 days, p.o.) improved AβO-induced memory impairment as well as reduced neuronal cell death, astrogliosis, and microgliosis in the hippocampus. In addition, GCD prevented AβO-triggered synaptic disruption and cholinergic fiber loss. These results suggest that GCD may be useful in the prevention and treatment of AD.
authors.affiliation: Department of Oriental Pharmaceutical Science, College of Pharmacy and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors.forename: Jin Gyu
authors.initials: JG
authors.lastname: Choi
authors.forename: Minho
authors.initials: M
authors.lastname: Moon
authors.forename: Hyo Geun
authors.initials: HG
authors.lastname: Kim
authors.forename: Inhee
authors.initials: I
authors.lastname: Mook-Jung
authors.forename: Sun Yong
authors.initials: SY
authors.lastname: Chung
authors.forename: Tong Ho
authors.initials: TH
authors.lastname: Kang
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Eunjoo H
authors.initials: EH
authors.lastname: Lee
authors.forename: Myung Sook
authors.initials: MS
authors.lastname: Oh
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D009410:Nerve Degeneration / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010446:Peptide Fragments / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; C499382:Chunghyuldan; D004365:Drugs, Chinese Herbal; D010446:Peptide Fragments