title: Sedentary behavior is not associated with cardiometabolic risk in adults with abdominal obesity.
abstract: OBJECTIVE
  The primary aim of this study was to determine whether time spent in sedentary behaviors (SED) was associated with 2-hour glucose and insulin resistance in adults with abdominal obesity. We also examined the association between light physical activity (LPA) and sporadic (accumulated in bouts <10 minutes in duration) moderate-to-vigorous physical activity (MVPA) with glucose metabolism.
  
  
  METHODS
  Participants were 135 inactive, abdominally obese adults recruited from Kingston, Canada. SED and physical activity were determined by accelerometry over 7 days and summarized as SED (accelerometer counts/min <100), LPA (counts/min 100-1951), and MVPA (counts/min ≥1952). A 75 g oral glucose tolerance test was used to ascertain 2-hour glucose; the homeostasis model of assessment was used to determine insulin resistance (HOMA-IR); lipid, lipoproteins and blood pressure were determined using standard protocols. Secondary analyses considered the association between SED and physical activity with other cardiometabolic risk factors.
  
  
  RESULTS
  Participants spent 627.2±82.9 min/d in SED, 289.0±91.7 min/d in LPA and 19.2±13.5 min/d in MVPA. Neither SED nor the physical activity variables were associated with 2-hour glucose or HOMA-IR (p>0.05). In secondary analyses, SED was not associated with any cardiometabolic risk factor (p>0.1); with the exception of blood pressure (p<0.05), LPA was not associated with any cardiometabolic risk factor (p>0.1); and MVPA was independently associated with total cholesterol and triglycerides (p<0.05).
  
  
  CONCLUSIONS
  Objectively measured SED was not associated with 2-hr glucose or HOMA-IR. Our findings also suggest that the accumulation of LPA and sporadic MVPA is not associated with glucose metabolism in adults with abdominal obesity.
authors.affiliation: School of Kinesiology and Health Studies, Queen's University, Kingston, Canada.
authors.forename: K Ashlee
authors.initials: KA
authors.lastname: McGuire
authors.forename: Robert
authors.initials: R
authors.lastname: Ross
mesh_terms: D000328:Adult; D000368:Aged; D001519:Behavior; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009206:Myocardium / Q000378:metabolism*; D056128:Obesity, Abdominal / Q000378:metabolism* / Q000503:physiopathology*; D012044:Regression Analysis; D012307:Risk Factors; D057185:Sedentary Behavior
chemical_list: D005947:Glucose