title: MMP-2/MMP-9 plasma level and brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke.
abstract: Cerebral amyloid angiopathy (CAA) is one of the main causes of intracerebral hemorrhage (ICH) in the elderly. Matrix metalloproteinases (MMPs) have been implicated in blood-brain barrier disruption and ICH pathogenesis. In this study, we determined the levels MMP-2 and MMP-9 in plasma and their brain expression in CAA-associated hemorrhagic stroke. Although MMP-2 and MMP-9 plasma levels did not differ among patients and controls, their brain expression was increased in perihematoma areas of CAA-related hemorrhagic strokes compared with contralateral areas and nonhemorrhagic brains. In addition, MMP-2 reactivity was found in β-amyloid (Aβ)-damaged vessels located far from the acute ICH and in chronic microbleeds. MMP-2 expression was associated to endothelial cells, histiocytes and reactive astrocytes, whereas MMP-9 expression was restricted to inflammatory cells. In summary, MMP-2 expression within and around Aβ-compromised vessels might contribute to the vasculature fatal fate, triggering an eventual bleeding.
authors.affiliation: Neurovascular Research Laboratory, Institut de Recerca Neurovascular Unit. Neurology and Medicine Departments, Universitat Autònoma de Barcelona, Spain. 31862jmv@comb.cat
authors.forename: Mar
authors.initials: M
authors.lastname: Hernandez-Guillamon
authors.forename: Elena
authors.initials: E
authors.lastname: Martinez-Saez
authors.forename: Pilar
authors.initials: P
authors.lastname: Delgado
authors.forename: Sophie
authors.initials: S
authors.lastname: Domingues-Montanari
authors.forename: Cristina
authors.initials: C
authors.lastname: Boada
authors.forename: Anna
authors.initials: A
authors.lastname: Penalba
authors.forename: Mercè
authors.initials: M
authors.lastname: Boada
authors.forename: Jorge
authors.initials: J
authors.lastname: Pagola
authors.forename: Olga
authors.initials: O
authors.lastname: Maisterra
authors.forename: David
authors.initials: D
authors.lastname: Rodriguez-Luna
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Molina
authors.forename: Alex
authors.initials: A
authors.lastname: Rovira
authors.forename: José
authors.initials: J
authors.lastname: Alvarez-Sabin
authors.forename: Arantxa
authors.initials: A
authors.lastname: Ortega-Aznar
authors.forename: Joan
authors.initials: J
authors.lastname: Montaner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000097:blood; D001921:Brain / Q000098:blood supply / Q000201:enzymology* / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000201:enzymology / Q000473:pathology; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D020521:Stroke / Q000097:blood / Q000201:enzymology* / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9