title: Ieodomycins A-D, antimicrobial fatty acids from a marine Bacillus sp.
abstract: Bioassay-guided isolation of the EtOAc extract of a marine Bacillus sp., cultured in modified Bennett's broth medium, yielded four new antimicrobial fatty acids, named ieodomycins A-D. The planar structures of these new compounds were determined by extensive 1D and 2D NMR and HRESIMS spectroscopic data analysis. Their absolute configurations were elucidated by modified Mosher's method and literature data review. All four new compounds demonstrated antimicrobial activities in vitro.
authors.affiliation: Marine Natural Products Chemistry Laboratory, Korea Ocean Research & Development Institute, Ansan, P.O. Box 29, Seoul 425-600, Republic of Korea.
authors.forename: M A Mojid
authors.initials: MA
authors.lastname: Mondol
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Kim
authors.forename: Min Ah
authors.initials: MA
authors.lastname: Lee
authors.forename: Fakir Shahidullah
authors.initials: FS
authors.lastname: Tareq
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Shin
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001407:Bacillus / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012441:Saccharomyces cerevisiae / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D005231:Fatty Acids, Unsaturated; C561379:Ieodomycin A