title: The two-mutant problem: clonal interference in evolutionary graph theory.
abstract: In large asexual populations, clonal interference, whereby different beneficial mutations compete to fix in the population simultaneously, may be the norm. Results extrapolated from the spread of individual mutations in homogeneous backgrounds are found to be misleading in such situations: clonal interference severely inhibits the spread of beneficial mutations. In contrast with results gained in systems with just one mutation striving for fixation at any one time, the spatial structure of the population is found to be an important factor in determining the fixation probability when there are two beneficial mutations.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Paley
authors.forename: Sergei
authors.initials: S
authors.lastname: Taraskin
authors.forename: Stephen
authors.initials: S
authors.lastname: Elliott