title: Efficacy of predictive modeling as a scientific criterion in dermal hazard identification for assignment of skin notations.
abstract: Skin notations (SNs) represent a hazard characterization tool for alerting workers of health hazards associated with dermal contact with chemicals. This study evaluated the efficacy of a predictive model utilized by the National Institute for Occupational Safety and Health to identify dermal hazards based on potential of systemic absorption compared to hazard assignments based on dermal lethal dose 50% or logarithm of octanol-water partition coefficient. A total of 480 chemicals assigned an SN from at least one of seven institutes were selected and partitioned into seven hazard categories by frequency of SN assignment to provide a basis of evaluation for the predictivity of the examined criteria. We find that all three properties serve as a qualitative indicator in support of a dichotomous decision on dermal hazard; the predictive modeling was identified from a multiple regression analysis as the most significant indicator. The model generated estimates that corresponded to anticipated hazard potentials, suggesting a role of the model to further serve as a hazard-ranking tool. The hazard-ranking capability of the model was consistent with the scheme of acute toxicity classification in the Globally Harmonized System of Classification and Labeling of Chemicals.
authors.affiliation: Department of Occupational Safety and Health, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan. chencp@mail.cmu.edu.tw
authors.forename: Chen-Peng
authors.initials: CP
authors.lastname: Chen
authors.forename: Heinz W
authors.initials: HW
authors.lastname: Ahlers
authors.forename: G
authors.initials: G
authors.lastname: Scott Dotson
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Lin
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Chang
authors.forename: Andrew
authors.initials: A
authors.lastname: Maier
authors.forename: Bernard
authors.initials: B
authors.lastname: Gadagbui
mesh_terms: D000279:Administration, Cutaneous; D000280:Administration, Inhalation; D000287:Administration, Topical; D020405:Dermis; D015386:Hazardous Substances / Q000145:classification* / Q000493:pharmacokinetics / Q000633:toxicity; D006801:Humans; D007928:Lethal Dose 50; D016014:Linear Models; D008954:Models, Biological; D009314:National Institute for Occupational Safety and Health, U.S. / Q000592:standards*; D016273:Occupational Exposure / Q000009:adverse effects / Q000145:classification* / Q000592:standards*; D016272:Occupational Health; D012867:Skin; D012871:Skin Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D014481:United States
chemical_list: D015386:Hazardous Substances