title: Comparison of 8-h urine protein and random urinary protein-to-creatinine ratio with 24-h urine protein in pregnancy.
abstract: OBJECTIVE
  To evaluate the relationship between 24-h and 8-h urinary protein excretion and protein-to-ceratinine (p:c) ratio in random urine sample. As well as determining a best cutoff for p:c ratio for accurately diagnose significant proteinuria.
  
  
  METHODS
  Fifty hospitalized pregnant women who need 24 h urine collection for medical complications were studied. At first for each patient protein-to-createnin ratio in random urine sample was done. Then 8- and 24-h urinary protein estimation was performed. The 24-h and 8-h urinary protein were compared to urinary p:c ratio in random urine sample.
  
  
  RESULTS
  There were significant correlations (p < 0.001) between protein levels of 24-h and 8-h urine collections (r = 0.75), 24-h and random urine p:c ratio (r = 0.97) as well as 8-h and random urine p:c ratio (r = 0.79). Mean protein levels were significantly higher in group with proteinuria ≥ 300 mg/24 h in these three types of urine samples (p < 0.001). We found cutoff levels of 105 mg for 8-h urine sample and of 0.18 for p:c ratio.
  
  
  CONCLUSIONS
  This study showed that 8-h urine protein or random p:c ratio in a single-voided urine can be appropriate methods for detection of proteinuria in the shorter period than 24-h urine protein.
authors.affiliation: Department of Perinatology, Tehran University of Medical Sciences, Maternal Fetal Neonatal Research Center, Imam Khomeini Hospital, Tehran, Iran. drkhazardoost@yahoo
authors.forename: Soghra
authors.initials: S
authors.lastname: Khazardoost
authors.lastname: Maryamnoorzadeh
authors.forename: Ali
authors.initials: A
authors.lastname: Abdollahi
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Shafaat
mesh_terms: D000328:Adult; D003404:Creatinine / Q000652:urine*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000652:urine*; D011507:Proteinuria / Q000175:diagnosis* / Q000652:urine*; D055815:Young Adult
chemical_list: D003404:Creatinine