title: Glycine N-methyltransferase affects urinary 1-hydroxypyrene and 8-hydroxy-2'-deoxyguanosine levels after PAH exposure.
abstract: OBJECTIVE
  The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs).
  
  
  METHODS
  The study participants included 289 coke-oven workers from a steel company in Taiwan. Personal air samples, spot urine samples, peripheral blood samples, and questionnaires were used to quantify PAH exposure, oxidative DNA damage, GNMT gene polymorphisms, demographic data, and environmental pollutants.
  
  
  RESULTS
  Urinary 1-OHP level, GNMT STRP1 genotype, and worksite were significant predictors of urinary 8-OHdG levels after adjustments were made for covariates.
  
  
  CONCLUSIONS
  This study suggests that GNMT STRP1 could modulate urinary 1-OHP and 8-OHdG levels in coke-oven workers exposed to PAHs.
authors.affiliation: Division of Preventive Medicine, Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Chen
authors.forename: Chiao-Wei
authors.initials: CW
authors.lastname: Ho
authors.forename: Yu-Chuen
authors.initials: YC
authors.lastname: Huang
authors.forename: Kuen-Yuh
authors.initials: KY
authors.lastname: Wu
authors.forename: Ming-Tseng
authors.initials: MT
authors.lastname: Wu
authors.forename: Hueiwang Anna
authors.initials: HA
authors.lastname: Jeng
authors.forename: Chiou-Jong
authors.initials: CJ
authors.lastname: Chen
authors.forename: Tung-Sheng
authors.initials: TS
authors.lastname: Shih
authors.forename: Ching-Huang
authors.initials: CH
authors.lastname: Lai
authors.forename: Chih-Hong
authors.initials: CH
authors.lastname: Pan
authors.forename: Yi-Ming Arthur
authors.initials: YM
authors.lastname: Chen
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D003077:Coke / Q000633:toxicity*; D003430:Cross-Sectional Studies; D004249:DNA Damage / Q000187:drug effects; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D050938:Glycine N-Methyltransferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D011110:Polymorphism, Genetic; D011721:Pyrenes / Q000378:metabolism*; D013232:Steel; D013624:Taiwan / Q000453:epidemiology
chemical_list: D003077:Coke; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; D013232:Steel; D000080242:8-Hydroxy-2'-Deoxyguanosine; D050938:Glycine N-Methyltransferase; D003849:Deoxyguanosine; C033146:1-hydroxypyrene