title: Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men.
abstract: BACKGROUND
  Combined effects between mitochondrial DNA 5178 (Mt5178) C/A polymorphism and alcohol consumption on the risk of hypertension or hyperuricemia have been reported. The objective of this study was to investigate whether Mt5178 C/A polymorphism modulates the effects of alcohol consumption on the risk of dyslipidemia.
  
  
  METHODS
  A total of 394 male subjects were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effect of Mt5178 polymorphism and alcohol consumption on the risk of dyslipidemia was conducted.
  
  
  RESULTS
  For men with Mt5178C, alcohol consumption was significantly and negatively associated with the risk of hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol ≥ 140 mg/dl) (P for trend = 0.015). After adjustment for age, body mass index (BMI), habitual smoking, coffee consumption and use of antihypertensive medicine, the odds ratio (OR) for hyper-LDL cholesterolemia was significantly lower in daily drinkers with Mt5178C than non-drinkers with Mt5178C (OR = 0.360, 95% confidence intervals: 0.153-0.847). A significant and negative association between alcohol consumption and serum LDL cholesterol levels was also observed in Mt5178C genotypic men (P for trend < 0.01). On the other hand, the association between Mt5178A genotype and risk of hyper-LDL cholesterolemia does not appear to depend on alcohol consumption.
  
  
  CONCLUSIONS
  For Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia.
authors.affiliation: Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Akatsuki
authors.initials: A
authors.lastname: Kokaze
authors.forename: Mamoru
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Naomi
authors.initials: N
authors.lastname: Matsunaga
authors.forename: Kanae
authors.initials: K
authors.lastname: Karita
authors.forename: Masao
authors.initials: M
authors.lastname: Yoshida
authors.forename: Naoki
authors.initials: N
authors.lastname: Shimada
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Ohtsu
authors.forename: Takako
authors.initials: T
authors.lastname: Shirasawa
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ochiai
authors.forename: Taku
authors.initials: T
authors.lastname: Ito
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hoshino
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takashima
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D008078:Cholesterol, LDL / Q000097:blood*; D004272:DNA, Mitochondrial / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009245:NADH Dehydrogenase / Q000235:genetics; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: D008078:Cholesterol, LDL; D004272:DNA, Mitochondrial; D009245:NADH Dehydrogenase; C521326:NADH dehydrogenase subunit 2, human