title: Lack of relationship between endothelial nitric oxide synthase gene 4b/a and T-786C polymorphisms with preeclampsia in southeast of Iran.
abstract: OBJECTIVE
  Preeclampsia is an important disorder of pregnancy that carries a severe morbidity and mortality risk for both mother and fetus. A large number of studies have shown that abnormalities in nitric oxide synthesis may contribute to the development of preeclampsia.
  
  
  METHODS
  We examined the relationship between the endothelial nitric oxide synthase (eNOS) gene 4b/a and T-786C polymorphisms with preeclampsia (PE) in 123 preeclamptic pregnant women and 142 healthy pregnant women in the southeast of Iran.
  
  
  RESULTS
  Our findings indicate that the 4b/a and T-786C polymorphisms of eNOS gene do not have any association with preeclampsia, but we found that the risk of preeclampsia was twofold in Afghan women in contrast to Persian and Balooch women. In a backward stepwise multiple regression analysis, the Afghan race and the history of preeclampsia were the risk factors for preeclampsia.
  
  
  CONCLUSIONS
  We conclude that the presence of 4b/a and T-786C polymorphisms were not risk factors for preeclampsia.
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Salimi
authors.forename: Anoosh
authors.initials: A
authors.lastname: Naghavi
authors.forename: Mojgan
authors.initials: M
authors.lastname: Mokhtari
authors.forename: Mehrangiz
authors.initials: M
authors.lastname: Noora
authors.forename: Minoo
authors.initials: M
authors.lastname: Yaghmaei
mesh_terms: D000328:Adult; D000346:Afghanistan / Q000208:ethnology; D000483:Alleles; D003430:Cross-Sectional Studies; D004727:Endothelium; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007492:Iran / Q000453:epidemiology; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000208:ethnology* / Q000235:genetics*; D011247:Pregnancy; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D052250:Nitric Oxide Synthase Type III