title: The first case of primary testicular germ cell tumor containing nephroblastoma as the only one non-germ cell component.
abstract: Adult extrarenal nephroblastomas (Wilms' tumor) are extremely rare tumors. They show a higher incidence of non-seminomatous elements and these so-called 'teratoid' Wilms' tumors are suggested to be of germ cell origin. To date, however, the number of reported cases with gonadal teratoma containing nephroblastoma is very low, and due to this reason, there are no standardized criteria for the categorization and treatment of these lesions. To our knowledge, the first case of nephroblastoma arising in a non-atrophic testis has been reported and it is associated with a teratoma as morphologically identifiable germ cell tumor and rhabdomyosarcoma as a second non-germ cell element. We report the second case of an adult nephroblastoma that arose within the primary testicular teratoma in a non-atrophic testis. Teratoma and nephroblastoma within the same testis may have an important point to clarify the developmental mechanism in nephroblastomatous differentiation of germ cell tumors.
authors.affiliation: İstanbul Üniversitesi Onkoloji Enstitüsü, Çapa, 34093 İstanbul, Turkey. drkeskin76@hotmail.com
authors.forename: Serkan
authors.initials: S
authors.lastname: Keskin
authors.forename: Meltem
authors.initials: M
authors.lastname: Ekenel
authors.forename: Mert
authors.initials: M
authors.lastname: Başaran
authors.forename: Can
authors.initials: C
authors.lastname: Aksu
authors.forename: Işin
authors.initials: I
authors.lastname: Kiliçaslan
authors.forename: Murat
authors.initials: M
authors.lastname: Tunç
authors.forename: Sevil
authors.initials: S
authors.lastname: Bavbek
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001761:Bleomycin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D043823:Taxoids / Q000008:administration & dosage; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D009396:Wilms Tumor / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D055815:Young Adult
chemical_list: D043823:Taxoids; D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin; D007069:Ifosfamide