title: Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria.
abstract: In order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in the second and third trimesters of pregnancy and with Plasmodium vivax malaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days. The same women were studied again at 3 months postpartum. Plasma was analyzed for amodiaquine and desethylamodiaquine by use of a liquid chromatography-tandem mass spectrometry method. Individual concentration-time data were evaluated using noncompartmental analysis. There were no clinically relevant differences in the pharmacokinetics of amodiaquine and desethylamodiaquine between pregnant (n = 24) and postpartum (n = 18) women. The results suggest that the current amodiaquine dosing regimen is adequate for the treatment of P. vivax infections during pregnancy.
authors.affiliation: Shoklo Malaria Research Unit, 68/30 Bantung Road, P.O. Box 46, Mae Sot, Tak 63110, Thailand.
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Rijken
authors.forename: Rose
authors.initials: R
authors.lastname: McGready
authors.forename: Vincent
authors.initials: V
authors.lastname: Jullien
authors.forename: Joel
authors.initials: J
authors.lastname: Tarning
authors.forename: Niklas
authors.initials: N
authors.lastname: Lindegardh
authors.forename: Aung Pyae
authors.initials: AP
authors.lastname: Phyo
authors.forename: Aye Kyi
authors.initials: AK
authors.lastname: Win
authors.forename: Poe
authors.initials: P
authors.lastname: Hsi
authors.forename: Mireille
authors.initials: M
authors.lastname: Cammas
authors.forename: Pratap
authors.initials: P
authors.lastname: Singhasivanon
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
authors.forename: François
authors.initials: F
authors.lastname: Nosten
mesh_terms: D000293:Adolescent; D000328:Adult; D000655:Amodiaquine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000962:Antimalarials / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016780:Malaria, Vivax / Q000097:blood / Q000188:drug therapy*; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000962:Antimalarials; D000655:Amodiaquine; C047386:desethylamodiaquine