title: Palisade vessels as a new histologic marker of esophageal origin in ER specimens from columnar-lined esophagus.
abstract: It is difficult for surgical pathologists to determine the origin of tissues in samples taken from the columnar-lined esophagus (CLE) or stomach by biopsy or endoscopic resection (ER) on the basis of histologic examination alone. We examined histopathologically a single section (5 to 22 mm in size; mean, 12 mm) from each of 66 cases of CLE (36 short segments, 30 long segments) from German patients with reference to 3 histologic markers of esophageal origin: esophageal glands proper and/or ducts, squamous islands, and double muscularis mucosae, all of which had been reported previously, and palisade vessels as a new histologic parameter as well. Palisade vessels were defined histologically as veins >100 μm in size in and above the original muscularis mucosae. Esophageal glands proper and/or ducts, squamous islands, and double muscularis mucosae were seen in 33%, 18%, and 71% of the specimens, respectively. Palisade longitudinal vessels were observed in 78% and 63% of specimens of short-segment and long-segment CLE, respectively. Palisade vessels were never seen in ER specimens from the stomach or in the middle esophagus and stomach among control autopsy specimens. At least 1 of these 4 markers was seen in 88% of the sections. Therefore, ER specimens were confirmed to originate from CLE in 88% of single histologic sections of CLE on the basis of histologic examination alone.
authors.affiliation: Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Aida
authors.forename: Michael
authors.initials: M
authors.lastname: Vieth
authors.forename: Christian
authors.initials: C
authors.lastname: Ell
authors.forename: Andrea
authors.initials: A
authors.lastname: May
authors.forename: Oliver
authors.initials: O
authors.lastname: Pech
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hoshihara
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kumagai
authors.forename: Kenro
authors.initials: K
authors.lastname: Kawada
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Hishima
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tateishi
authors.forename: Motoji
authors.initials: M
authors.lastname: Sawabe
authors.forename: Tomio
authors.initials: T
authors.lastname: Arai
authors.forename: Masaaki
authors.initials: M
authors.lastname: Matsuura
authors.forename: Kaiyo
authors.initials: K
authors.lastname: Takubo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D001706:Biopsy; D002277:Carcinoma / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D004943:Esophagogastric Junction / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D004945:Esophagoscopy; D004947:Esophagus / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009092:Mucous Membrane / Q000098:blood supply / Q000473:pathology; D013270:Stomach / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D014680:Veins / Q000473:pathology