title: PKM2 and the tricky balance of growth and energy in cancer.
abstract: In this issue of Molecular Cell, Lv et al. (2011) identify a novel feedback mechanism in which increased glycolysis induces the acetylation and chaperone-mediated autophagic degradation of the glycolytic regulator PKM2, revealing a novel metabolic feedback loop that drives tumor growth.
authors.affiliation: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Macintyre
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Rathmell