title: Effects of vitamin D receptor gene polymorphisms on susceptibility to disease and bone mineral density in Turkish patients with type 1 diabetes mellitus.
abstract: BACKGROUND
  Vitamin D receptor (VDR) gene is regarded as one of the candidate genes for type 1 diabetes mellitus (T1D) susceptibility and of some genetic factors involved in the development of osteoporosis in this group.
  
  
  METHODS
  We characterized the VDR gene polymorphism (BsmI, ApaI, TaqI, FokI and Cdx-2 binding site) in a group of Turkish patients with T1D (n=90) and correlated respective VDR genotypes with the bone mass and some parameters of bone turnover.
  
  
  RESULTS
  There were no differences in the genotype frequencies of the BsmI, ApaI, TaqI and Cdx-2 polymorphisms in patients and control subjects. We found a significantly higher prevalence of the F allele/the FF genotype in the patients compared to controls (p=0,0031, odds 1.96 (1,27-3,01)). We observed no difference in markers of bone turnover (Serum levels of osteocalcin, PINP and alkaline phosphatase, urinary levels of calcium/ creatinine and N-telopeptid) among different VDR genotypes. No correlation was found between VDR polymorphisms and DEXA measurements of these patients.
  
  
  CONCLUSIONS
  Although the FF genotype was found to be a risk factor in a Turkish population, elucidation of this result is necessary in other larger study groups drawn from the same ethnic population.
authors.affiliation: Department of Pediatrics, Akdeniz University School of Medicine, Antalya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kocabaş
authors.forename: G
authors.initials: G
authors.lastname: Karagüzel
authors.forename: N
authors.initials: N
authors.lastname: Imir
authors.forename: U
authors.initials: U
authors.lastname: Yavuzer
authors.forename: S
authors.initials: S
authors.lastname: Akçurin
mesh_terms: D015519:Bone Density; D000071616:CDX2 Transcription Factor; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D015534:Trans-Activators / Q000502:physiology; D014421:Turkey
chemical_list: D000071616:CDX2 Transcription Factor; D018398:Homeodomain Proteins; D018167:Receptors, Calcitriol; D015534:Trans-Activators