title: Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc.
abstract: Current study was conducted to identify constituents of Taxus wallichiana Zucc. that might be responsible for its folk use in anti-inflammatory conditions. Taxusabietane A was isolated from the bark extract of Taxus wallichiana Zucc. Taxusabietane A was analyzed for in-vitro and in-vivo anti-inflammatory activities using Lipoxygenase (LOX) inhibition assay and carrageenan-induced paw edema model. Taxusabietane A revealed considerable LOX inhibitory activity with the IC(50) value being 57 ± 0.31. Standard compound Baicalein showed the IC(50) value being 22.1 ± 0.03 μM. Taxusabietane A also showed significant (5 and 10 mg/kg) anti-inflammatory activity induced by carrageenan. However, this study highlighted the potential of Taxusabietane A to be further explored as a new lead compound for management of conditions associated with inflammation.
authors.affiliation: Department of Pharmacy, University of Peshawar, 25120, Pakistan. inam_marwat333@yahoo.com
authors.forename: Inamullah
authors.initials: I
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Nisar
authors.forename: Muhammad Raza
authors.initials: MR
authors.lastname: Shah
authors.forename: Hamidullah
authors.initials: H
authors.lastname: Shah
authors.forename: Syed Naeemuddin
authors.initials: SN
authors.lastname: Gilani
authors.forename: Farah
authors.initials: F
authors.lastname: Gul
authors.forename: Syed Muhammad
authors.initials: SM
authors.lastname: Abdullah
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ismail
authors.forename: Nematullah
authors.initials: N
authors.lastname: Khan
authors.forename: Waqar Ahmad
authors.initials: WA
authors.lastname: Kaleem
authors.forename: Mughal
authors.initials: M
authors.lastname: Qayum
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.lastname: Obaidullah
authors.lastname: Samiullah
authors.forename: Majeed
authors.initials: M
authors.lastname: Ullah
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D044950:Flavanones / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D010616:Phenanthrenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D020946:Taxus / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D044950:Flavanones; D016859:Lipoxygenase Inhibitors; D010616:Phenanthrenes; D010936:Plant Extracts; C570378:taxusabietane A; C006680:baicalein; D002351:Carrageenan