title: [Study on the expression and clinical significance of MMP9 and MVD in the external auditory canal and middle ear squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of MMP9 and MVD in the carcinogenesis of squamous cell carcinoma of external auditory canal and middle ear.
  
  
  METHODS
  Immunohistochemical SP method was used to detect the expression of MMP9 and MVD proteins in 26 squamous cell carcinoma tissues of external auditory canal and middle ear and 20 normal external ear canal skin tissues.
  
  
  RESULTS
  The positive rate of MMP9 in squamous cell carcinoma tissues of external auditory canal and middle ear was 73.1% (19/26) lower than that in the normal external ear canal skin tissues 25.0% (5/20). The positive rates of CD34 were 33.58 +/- 3.04 and 22.50 +/- 5.22, respectively. The positive rates of MMP9 and CD34 were correlated with the histological grade and tumor grade, but had no relationship with age and sex. The positive rates between MMP9 and CD34 were related (r=0.42, P<0.05).
  
  
  CONCLUSIONS
  MMP9 may be involved in the carcinogenesis of squamous cell carcinoma of external auditory canal and middle ear, and may play an important role in the invasion and metastasis of squamous cell carcinoma of external auditory canal and middle ear. MMP9 and CD34 play a cooperative role in the process of squamous cell carcinoma of external auditory canal and middle ear.
authors.affiliation: Department of Otolaryngology, the Third Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325200, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.forename: Wuqing
authors.initials: W
authors.lastname: Wang
authors.forename: Jianfu
authors.initials: J
authors.lastname: Chen
authors.forename: Chongxi
authors.initials: C
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000098:blood supply* / Q000378:metabolism*; D004424:Ear Canal / Q000378:metabolism; D004428:Ear Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D004432:Ear, Middle / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D009389:Neovascularization, Pathologic
chemical_list: D018952:Antigens, CD34; D020780:Matrix Metalloproteinase 9