title: Preparation, structure, and in vitro chemical durability of yttrium phosphate microspheres for intra-arterial radiotherapy.
abstract: Chemically durable microspheres containing yttrium and/or phosphorus are useful for intra-arterial radiotherapy. In this study, we attempted to prepare yttrium phosphate (YPO₄) microspheres with high chemical durability. YPO₄ microspheres with smooth surfaces and diameters of around 25 μm were successfully obtained when gelatin droplets containing yttrium and phosphate ions were cooled and solidified in a water-in-oil emulsion and then heat-treated at 1100°C. The chemical durability of the heat-treated microspheres in a simulated body fluid at pH = 6 and 7 was high enough for clinical application of intra-arterial radiotherapy.
authors.affiliation: Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, Aoba-ku, Sendai 980-8579, Japan. m-kawa@ecei.tohoku.ac.jp
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kawashita
authors.forename: Naoko
authors.initials: N
authors.lastname: Matsui
authors.forename: Zhixia
authors.initials: Z
authors.lastname: Li
authors.forename: Toshiki
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Kanetaka
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001826:Body Fluids / Q000737:chemistry; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy; D008422:Materials Testing; D008863:Microspheres; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry*; D018787:Radiation Oncology / Q000295:instrumentation / Q000379:methods*; D013499:Surface Properties; D015019:Yttrium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D010710:Phosphates; D015019:Yttrium