title: Iodine-123 fluoropropyl-carbomethoxy-3-β-(4-iodophenyltropane) single-photon emission computed tomography findings before and after electroconvulsive therapy in major depressive disorder with Parkinsonism.
abstract: BACKGROUND
  To date, only a few cases of improvement of Parkinsonism in depressed patients treated with electroconvulsive therapy (ECT) have been reported. However, no functional imaging data are available to support this finding.
  
  
  OBJECTIVE
  To describe the first observation of increase in dopamine transporter uptake after ECT.
  
  
  METHODS
  Iodine-123 fluoropropyl-carbomethoxy-3-β-(4-iodophenyltropane) single-photon emission computed tomographic imaging was conducted in a 77-year-old depressed patient displaying symptoms of Parkinson disease (PD) before and after a series of 12 bilateral ECTs.
  
  
  RESULTS
  The patient displayed improvement in PD symptoms and increase in dopamine transporter uptake after ECT.
  
  
  CONCLUSIONS
  Our observation suggests that the PD symptoms and decrease in striatal uptake appearing in the context of a depressive episode might warrant further attention, as they might be reversible.
authors.affiliation: Laboratoire du Stress Traumatique, Université de Toulouse, Toulouse, France. bui.e@chu-toulouse.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Bui
authors.forename: Julien
authors.initials: J
authors.lastname: Delrieu
authors.forename: Thomas
authors.initials: T
authors.lastname: Wagner
authors.forename: Julie
authors.initials: J
authors.lastname: Rieu
authors.forename: Etienne
authors.initials: E
authors.lastname: Véry
authors.forename: Clara
authors.initials: C
authors.lastname: Letamendia
authors.forename: Pierre
authors.initials: P
authors.lastname: Payoux
authors.forename: Laurent
authors.initials: L
authors.lastname: Schmitt
mesh_terms: D000368:Aged; D003865:Major Depressive Disorder / Q000150:complications* / Q000628:therapy*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D004565:Electroconvulsive Therapy; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D020734:Parkinsonian Disorders / Q000150:complications* / Q000628:therapy*; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D007457:Iodine Radioisotopes