title: Baseline determination in social, health, and genetic areas in communities affected by glyphosate aerial spraying on the northeastern Ecuadorian border.
abstract: The northeastern Ecuadorian border has undergone aerial spraying with an herbicide mix that contains surfactants and adjuvants, executed by the Colombian Government. The purpose of this study was to diagnose social, health, and genetic aspects of the people affected by glyphosate. For this objective to be achieved, 144 people were interviewed, and 521 medical diagnoses and 182 peripheral blood samples were obtained. Genotyping of GSTP1 Ile105Val, GPX-1 Pro198Leu, and XRCC1 Arg399Gln polymorphisms were analyzed, using PCR-RFLP technique. The assessment of chromosomal aberrations was performed, obtaining 182 karyotypes. Malnutrition in children was 3%. Of the total population, 7.7% had children with malformations, and the percentage of abortions was 12.7%. Concerning genotyping, individuals with GSTP1 Val/Val obtained an odds ratio of 4.88 (p < 0.001), and Ile/Val individuals, together with Val/Val individuals, had an odds ratio of 2.6 (p < 0.05). In addition, GPX-1 Leu/Leu individuals presented an odds ratio (OR) of 8.5 (p < 0.05). Regarding karyotyping, the 182 individuals had normal karyotypes. In conclusion, the study population did not present significant chromosomal and DNA alterations. The most important social impact was fear. We recommend future prospective studies to assess the communities.
authors.affiliation: Instituto de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador. cpazymino@udla.edu.ec
authors.forename: César
authors.initials: C
authors.lastname: Paz-y-Miño
authors.forename: María José
authors.initials: MJ
authors.lastname: Muñoz
authors.forename: Adolfo
authors.initials: A
authors.lastname: Maldonado
authors.forename: Carolina
authors.initials: C
authors.lastname: Valladares
authors.forename: Nadia
authors.initials: N
authors.lastname: Cumbal
authors.forename: Catalina
authors.initials: C
authors.lastname: Herrera
authors.forename: Paulo
authors.initials: P
authors.lastname: Robles
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Sánchez
authors.forename: Andrés
authors.initials: A
authors.lastname: López-Cortés
mesh_terms: D004484:Ecuador / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005998:Glycine / Q000031:analogs & derivatives* / Q000506:poisoning; D006304:Health Status; D006306:Health Surveys; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D007621:Karyotyping; D008297:Male; D009154:Mutation; D012959:Socioeconomic Factors; D000097797:Glyphosate
chemical_list: D005998:Glycine; D006540:Herbicides; D000097797:Glyphosate