title: Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus.
abstract: The purpose of this study was to investigate the effects of probiotic and conventional yogurt on the lipid profile in type 2 diabetic people. In a randomized double-blind controlled trial, 60 people (23 males and 37 females) with type 2 diabetes and low-density lipoprotein cholesterol (LDL-C) greater than 2.6 mmol/L were assigned to 2 groups. Participants consumed daily 300 g of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 or 300 g of conventional yogurt for 6 wk. Fasting blood samples, anthropometric measurements and 3-d, 24-h dietary recalls were collected at the baseline and at the end of the trial. Probiotic yogurt consumption caused a 4.54% decrease in total cholesterol and a 7.45% decrease in LDL-C compared with the control group. No significant changes from baseline were shown in triglyceride and high-density lipoprotein cholesterol (HDL-C) in the probiotic group. The total cholesterol:HDL-C ratio and LDL-C:HDL-C ratio as atherogenic indices significantly decreased in the probiotic group compared with the control group. Probiotic yogurt improved total cholesterol and LDL-C concentrations in type 2 diabetic people and may contribute to the improvement of cardiovascular disease risk factors.
authors.affiliation: Department of Food Science and Technology, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: H S
authors.initials: HS
authors.lastname: Ejtahed
authors.forename: J
authors.initials: J
authors.lastname: Mohtadi-Nia
authors.forename: A
authors.initials: A
authors.lastname: Homayouni-Rad
authors.forename: M
authors.initials: M
authors.lastname: Niafar
authors.forename: M
authors.initials: M
authors.lastname: Asghari-Jafarabadi
authors.forename: V
authors.initials: V
authors.lastname: Mofid
authors.forename: A
authors.initials: A
authors.lastname: Akbarian-Moghari
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001644:Bifidobacterium; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007779:Lactobacillus acidophilus; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000494:pharmacology*; D015014:Yogurt / Q000382:microbiology*
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002784:Cholesterol