title: Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb.
abstract: Establishment of a neural stem cell niche in the postnatal subependymal zone (SEZ) and the rostral migratory stream (RMS) is required for postnatal and adult neurogenesis in the olfactory bulbs (OB). We report the discovery of a cellular lineage in the SEZ-RMS-OB continuum, the specification of which is dependent on the expression of the forkhead transcription factor Foxj1 in mice. Spatially and temporally restricted Foxj1+ neuronal progenitors emerge during embryonic periods, surge during perinatal development, and are active only for the first few postnatal weeks. We show that the development of the unique Foxj1-derived lineage is dependent on Foxj1 expression and is required for overall postnatal neurogenesis in the OB. Strikingly, the production of neurons from Foxj1+ progenitors significantly declines after the early postnatal weeks, but Foxj1-derived neurons in the OB persist during adult periods. For the first time, our study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods.
authors.affiliation: Center for Comparative Medicine and Translational Research, Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA.
authors.forename: Benoit V
authors.initials: BV
authors.lastname: Jacquet
authors.forename: Nagendran
authors.initials: N
authors.lastname: Muthusamy
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Sommerville
authors.forename: Guanxi
authors.initials: G
authors.lastname: Xiao
authors.forename: Huixuan
authors.initials: H
authors.lastname: Liang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Holtzman
authors.forename: H Troy
authors.initials: HT
authors.lastname: Ghashghaei
mesh_terms: D000818:Animals; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009830:Olfactory Bulb / Q000196:embryology* / Q000502:physiology*; D016548:Prosencephalon / Q000196:embryology* / Q000502:physiology*
chemical_list: C481963:FOXJ1 protein, mouse; D051858:Forkhead Transcription Factors