title: Domino process optimized via ab initio study for an alternative access to bicyclic lactams.
abstract: A totally new acid-free domino process to access highly functionalized bicyclic γ- and δ-lactams starting from commercially available and inexpensive ethoxymethylene derivatives is reported. Mechanisms elucidated by computational calculations led to new reaction conditions that boosted the yields up to 3.5 times higher.
authors.affiliation: URCOM, EA 3221, CNRS FR3038-INC3M, UFR S.T. de l' Université du Havre, BP 540, 25 rue Philippe Lebon, F-76058 Le Havre cedex, France. sebastien.comesse@univ-lehavre.fr
authors.forename: Sébastien
authors.initials: S
authors.lastname: Comesse
authors.forename: Arnaud
authors.initials: A
authors.lastname: Martel
authors.forename: Adam
authors.initials: A
authors.lastname: Daïch