title: Bone involvement in two cases of thoracic primary cutaneous diffuse large B-cell lymphoma, leg type.
abstract: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL-LT), is defined by a predominance of confluent sheets of centroblasts and immunoblasts, which strongly express Bcl-2 protein. This cutaneous lymphoma is mainly characterized by the development of skin lesions on the lower leg. Other localizations are possible (namely non-leg PCLBCL-LT) and usually affect younger patients. PCLBCL-LT is distinguished from the two other subtypes of primary cutaneous B-cell lymphomas by its immunohistopathological features, its aggressive clinical behaviour with a worse prognosis linked to skin recurrences, but also secondary extracutaneous spread. Bone involvement underlying skin lesions has been reported in few series and cases reports during PCLBCL-LT. We describe here two aggressive cases of PCLBCL-LT with high burden and infiltrative thoracic tumours, with localized bone involvement.
authors.affiliation: Department of Dermatology, Tenon Hospital, Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Lipowicz
authors.forename: Marie
authors.initials: M
authors.lastname: Beylot-Barry
authors.forename: Sylvain
authors.initials: S
authors.lastname: Choquet
authors.forename: Philippe
authors.initials: P
authors.lastname: Maksud
authors.forename: Béatrice
authors.initials: B
authors.lastname: Vergier
authors.forename: Anne-Flore
authors.initials: AF
authors.lastname: Albertini
authors.forename: Camille
authors.initials: C
authors.lastname: Frances
authors.forename: Stéphane
authors.initials: S
authors.lastname: Barete
mesh_terms: D000369:Aged, 80 and over; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms; D016190:Carboplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D000069283:Rituximab; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D035441:Thoracic Wall / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D005047:Etoposide; D016190:Carboplatin; D007069:Ifosfamide