title: Isolation and biological evaluation of jatrophane diterpenoids from Euphorbia dendroides.
abstract: From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multi-drug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, Center for Chemistry, University of Belgrade, Njegoševa 12, 11001 Belgrade, Serbia. aljancic@chem.bg.ac.rs
authors.forename: Ivana S
authors.initials: IS
authors.lastname: Aljancić
authors.forename: Milica
authors.initials: M
authors.lastname: Pesić
authors.forename: Slobodan M
authors.initials: SM
authors.lastname: Milosavljević
authors.forename: Nina M
authors.initials: NM
authors.lastname: Todorović
authors.forename: Milka
authors.initials: M
authors.lastname: Jadranin
authors.forename: Goran
authors.initials: G
authors.lastname: Milosavljević
authors.forename: Dragan
authors.initials: D
authors.lastname: Povrenović
authors.forename: Jasna
authors.initials: J
authors.lastname: Banković
authors.forename: Nikola
authors.initials: N
authors.lastname: Tanić
authors.forename: Ivanka D
authors.initials: ID
authors.lastname: Marković
authors.forename: Sabera
authors.initials: S
authors.lastname: Ruzdijić
authors.forename: Vlatka E
authors.initials: VE
authors.lastname: Vajs
authors.forename: Vele V
authors.initials: VV
authors.lastname: Tesević
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000037:antagonists & inhibitors / Q000378:metabolism; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D054548:Montenegro; D019906:Nuclear Magnetic Resonance, Biomolecular; D017239:Paclitaxel / Q000494:pharmacology
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C530345:jatrophane; D017239:Paclitaxel