title: [Hypoadiponectinemia leads to insulin resistance in OLETF rats: a preliminary study].
abstract: OBJECTIVE
  To investigate the association between plasma adiponectin and insulin resistance in OLETF rats.
  
  
  METHODS
  Twenty male Otsuka Long-Evans Tokushima Fatty (OLETF) rats and 10 male Long-evans Tokushima Otsuka (LETO) rats underwent oral glucose tolerance test (OGTT) at 13 and 40 weeks of age. At 8, 32 and 40 weeks of age, the rats were sacrificed to measure the blood glucose, plasma insulin and adiponectin levels, and serum levels of TG, CHOL and FFA.
  
  
  RESULTS
  The plasma adiponectin level was significantly decreased in 8-week-old OLETF rats compared with that of LETO rats (P<0.05). The plasma insulin level, TG, CHOL, and FFA were significantly higher in OLETF rats than in LETO rats at 32 and 40 weeks of age.
  
  
  CONCLUSIONS
  A decreased plasma level of adiponectin preludes insulin resistance and is inversely correlated to insulin sensitivity. Hypoadiponectinemia may be an important reason leading to insulin resistance.
authors.affiliation: Department of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. guoyu@fimmu.com
authors.forename: Yu
authors.initials: Y
authors.lastname: Guo
authors.forename: Bo
authors.initials: B
authors.lastname: Zhu
authors.forename: Chen-zhong
authors.initials: CZ
authors.lastname: Li
authors.forename: Yong-hua
authors.initials: YH
authors.lastname: Pan
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yao-ming
authors.initials: YM
authors.lastname: Xue
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D007333:Insulin Resistance; D008297:Male; D051381:Rats; D020334:Rats, Inbred OLETF; D020318:Rats, Long-Evans
chemical_list: D052242:Adiponectin; D007328:Insulin