title: Basic science offers a challenge for developing hemoglobin based oxygen carriers into therapeutic agents.
abstract: Experimental data, obtained during the course of several years, are connected into a coherent picture, which may help research for the development of HBOCs as therapeutic agents. Oxygen affinity, scavenging of nitric oxide, and yield of production of hemoglobin based oxygen carriers were the areas under consideration.
authors.affiliation: University of Maryland Medical School, Department of Biochemistry and Molecular Biology, Baltimore, MD 21201, USA. ebucci@umaryland.edu
authors.forename: Enrico
authors.initials: E
authors.lastname: Bucci
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000378:metabolism / Q000627:therapeutic use* / Q000633:toxicity; D055808:Drug Discovery / Q000379:methods*; D016166:Free Radical Scavengers / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001802:Blood Substitutes; D016166:Free Radical Scavengers; D006454:Hemoglobins; D009569:Nitric Oxide; D010100:Oxygen