title: Neurocysticercosis: local and systemic immune-inflammatory features related to severity.
abstract: Neurocysticercosis (NC) is caused by the establishment of Taenia solium cysticerci in the central nervous system. Previous studies have established that neuroinflammation plays a key role in the severity of the disease. However, the relationship between peripheral and local immune response remains inconclusive. This work studies the peripheral and local immune-inflammatory features and their relationships, toward the identification of potential peripheral immunologic features related to severity. A panel of cytokines was measured in paired cerebrospinal fluid (CSF) and in the supernatant of antigen-specific stimulated peripheral blood mononuclear cells samples (SN) in a total of 31 untreated inflammatory and non-inflammatory NC patients. Increased clinical and radiologic severity was associated with an increased cerebrospinal fluid cell count. A peripheral proliferative depression that negatively correlates with CSF cellularity and TNFα and that positively correlates with SN IL5 was observed in severe NC patients. These results provide evidences to support the systemic proliferative response as a biomarker to monitor the level of neuroinflammation, of possible value in the patients' follow-up during treatment.
authors.affiliation: Unidad Periférica del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía, Universidad Nacional Autónoma de México, México DF, México.
authors.forename: Brenda
authors.initials: B
authors.lastname: Sáenz
authors.forename: Agnes
authors.initials: A
authors.lastname: Fleury
authors.forename: Anahí
authors.initials: A
authors.lastname: Chavarría
authors.forename: Marisela
authors.initials: M
authors.lastname: Hernández
authors.forename: José C
authors.initials: JC
authors.lastname: Crispin
authors.forename: María I
authors.initials: MI
authors.lastname: Vargas-Rojas
authors.forename: Gladis
authors.initials: G
authors.lastname: Fragoso
authors.forename: Edda
authors.initials: E
authors.lastname: Sciutto
mesh_terms: D000818:Animals; D003552:Cysticercus / Q000276:immunology; D016207:Cytokines / Q000134:cerebrospinal fluid / Q000276:immunology; D005260:Female; D006801:Humans; D007107:Immune System / Q000276:immunology; D007249:Inflammation / Q000276:immunology*; D015848:Interleukin-5 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008297:Male; D020019:Neurocysticercosis / Q000276:immunology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D041201:Taenia solium / Q000276:immunology* / Q000472:pathogenicity; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; C508599:IL5 protein, human; D015848:Interleukin-5; D014409:Tumor Necrosis Factor-alpha