title: Prothrombin G20210A and factor V Leiden polymorphisms in stroke.
abstract: The molecular epidemiology of stroke is critically lacking in the developing world. We explored the relationships between genetics polymorphism and risk for ischemic stroke among the residents of Casablanca, Morocco. Ninety-one stroke patients matched 1:2 for their age, gender, and ethnic background to 182 healthy controls who were genotyped for the prothrombin G20210A mutation and factor V (FV) Leiden and were assessed for conventional risk factors for stroke. No significant association was found between prothrombin gene mutation with stroke (p = .054). Regarding stroke subtypes, significant relationships between patients with a large artery disease subtype of stroke and this mutation was found compared to controls (p = .046). As a genetic risk factor to develop this event, a strong association was observed when adjusted for conventional vascular risk factors (adjusted OR, 4.3; p = .029). No FV Leiden was found. We suggest that prothrombin mutation but not FV Leiden should be considered as a modest genetic risk factor for large artery disease stroke subtype in the Moroccan population.
authors.affiliation: Laboratory of Genetic and Molecular Pathology, Medical School, Hassan II University, 19, rue Tarik-Ibn-Ziad, BP 9154, 10000, Casablanca, Morocco. thierrypal@yahoo.fr
authors.forename: Thierry Paluku
authors.initials: TP
authors.lastname: They-They
authors.forename: Omar
authors.initials: O
authors.lastname: Battas
authors.forename: Ilham
authors.initials: I
authors.lastname: Slassi
authors.forename: Mohamed Abdou
authors.initials: MA
authors.lastname: Rafai
authors.forename: Desire Tshala
authors.initials: DT
authors.lastname: Katumbay
authors.forename: Sellama
authors.initials: S
authors.lastname: Nadifi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin