title: Acinetobacter baumannii infection in patients with hematologic malignancies in intensive care unit: risk factors and impact on mortality.
abstract: OBJECTIVE
  We investigated the characteristics of Acinetobacter baumannii infection in critically ill patients with hematologic malignancies.
  
  
  METHODS
  The prospectively collected data of patients with hematologic malignancies admitted to a medical intensive care unit of a university hospital from 2007 through 2010 were reviewed retrospectively.
  
  
  RESULTS
  One hundred twenty-eight patients were included in the study, among whom 35 (27%) developed 39 A baumannii infections. Pneumonia was the most common infection site of A baumannii. Presence of neutropenia, underlying hematologic malignancy, and the disease status did not affect the acquisition of the infection. Advancing age, prior exposure to aminoglycosides, central venous catheterization, and presence of nasogastric tube were the independent risk factors for the development of A baumannii infections. The mortality rate was higher in patients with A baumannii infections compared with the ones without (P = .009). However, in multivariate analysis, low Glasgow coma scale, prior immunosuppressive treatment, neutropenia, invasive mechanical ventilation, and severe sepsis were independently associated with mortality, whereas presence of A baumannii infection was not.
  
  
  CONCLUSIONS
  Despite the high mortality rate in critically ill patients with hematologic malignancies, presence of A baumannii infection was not an independent risk factor for mortality.
authors.affiliation: Department of Medical Intensive Care Unit, Gazi University School of Medicine, Besevler 06510 Ankara, Turkey. Electronic address: meldaturkoglu@yahoo.com.tr.
authors.forename: Melda
authors.initials: M
authors.lastname: Turkoglu
authors.affiliation: Department of Medical Intensive Care Unit, Gazi University School of Medicine, Besevler 06510 Ankara, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Mirza
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Gazi University School of Medicine, Besevler 06510 Ankara, Turkey.
authors.forename: Özlem Güzel
authors.initials: ÖG
authors.lastname: Tunçcan
authors.affiliation: Department of Medical Intensive Care Unit, Gazi University School of Medicine, Besevler 06510 Ankara, Turkey.
authors.forename: Gökmen Umut
authors.initials: GU
authors.lastname: Erdem
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Gazi University School of Medicine, Besevler 06510 Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Dizbay
authors.affiliation: Department of Hematology, Gazi University School of Medicine,Gazi University School of Medicine, Besevler 06510 Ankara, Turkey.
authors.forename: Münci
authors.initials: M
authors.lastname: Yağcı
authors.affiliation: Department of Medical Intensive Care Unit, Gazi University School of Medicine, Besevler 06510 Ankara, Turkey.
authors.forename: Gülbin
authors.initials: G
authors.lastname: Aygencel
authors.affiliation: Department of Hematology, Gazi University School of Medicine,Gazi University School of Medicine, Besevler 06510 Ankara, Turkey.
authors.forename: Gülsan
authors.initials: G
authors.lastname: Türköz Sucak
mesh_terms: D000151:Acinetobacter Infections / Q000150:complications* / Q000401:mortality; D040981:Acinetobacter baumannii / Q000302:isolation & purification*; D000328:Adult; D016638:Critical Illness; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications* / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology