title: Anti-baculovirus activity in a protein extracted from the exoskeleton of Pleuroncodes planipes [Decapoda: Galatheidae].
abstract: Antiviral activity (99.5% inhibition) against the Autographa californica polyhedrosis nuclear virus AcNPV+GFP was shown by a polypeptide of approximately 10 kDa, isolated from the exoskeleton of Pleuroncodes planipes, the pelagic red crab. This thermo-stable polypeptide retained its anti-viral properties after being exposed to 76 °C for 30 min and showed no apparent cytotoxic effect. Its anti-viral activity was observed when incubated with the virus, previous to the inoculation of cells. Using Tandem Mass Spectrometry (LC/ESI-MS/MS), this polypeptide showed sequence identity to a fragment of a myohemeritrin-like metalloprotein found in the Scoloplos armiger sea worm (VFYANLDEEHK).
authors.affiliation: Unidad de Investigación Médica en Inmunología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, Mexico DF, Mexico.
authors.forename: G
authors.initials: G
authors.lastname: Galvez-Romero
authors.forename: M
authors.initials: M
authors.lastname: Salas-Rojas
authors.forename: G Mendoza
authors.initials: GM
authors.lastname: Hernández
authors.forename: F
authors.initials: F
authors.lastname: Blanco-Favela
authors.forename: A
authors.initials: A
authors.lastname: Aguilar-Setién
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D016367:Baculoviridae / Q000187:drug effects*; D003386:Brachyura / Q000737:chemistry*; D034582:Integumentary System; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011506:Proteins