title: Monocyte and T-cell responses to exercise training in elderly subjects.
abstract: The purpose of this study was to examine the effects of exercise training on age-related impairment of immune parameters related to T-cell activation in elderly individuals. Twenty-four elderly subjects were assigned to an exercise training group (EXC: 3 men, 9 women; age 61-76 years) or a nonexercise control group (CON: 4 men, 8 women; age 62-79 years). Subjects in EXC participated in exercise sessions 2 d·wk(-1) for 12 weeks. The training session included stretching and endurance exercise (10 minutes), resistance training comprised leg extension, leg press, hip abduction, and hip adduction using exercise machine and each subject's body weight. Subjects in CON maintained their normal physical activity levels during the study period. Blood samples were collected before and after the training period. Samples were measured for the numbers of leukocytes, lymphocytes, and monocytes, and for CD3(+), CD4(+), CD8(+), CD28(+)CD4(+), CD28(+)CD8(+), TRL-4(+)CD14(+), and CD80(+)CD14(+) cells. The number of leukocytes, lymphocytes, monocytes, CD3(+), CD4(+), and CD8(+) cells did not change after 12 weeks in either EXC or CON. The number of CD28(+)CD8(+) cells increased significantly after training in EXC (p ≤ 0.05), although CON showed no significant change. In the EXC group, CD80(+)CD14(+) cell counts were significantly higher after training (p ≤ 0.05), but the TLR-4(+)CD14(+) cell counts were unchanged. In the CON group, no significant alteration existed in TLR-4(+)CD14(+) and CD80(+)CD14(+) cell numbers. In conclusion, exercise training in elderly people is associated with increased CD28-expressing Tc cells and CD80-expressing monocytes. Therefore, exercise training might upregulate monocyte and T-cell-mediated immunity in elderly people.
authors.affiliation: Faculty of Sport Sciences, Waseda University, Saitama, Japan. shimikazu@aoni.waseda.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Natsumi
authors.initials: N
authors.lastname: Suzuki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Imai
authors.forename: Katsuji
authors.initials: K
authors.lastname: Aizawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nanba
authors.forename: Yukichi
authors.initials: Y
authors.lastname: Hanaoka
authors.forename: Shinya
authors.initials: S
authors.lastname: Kuno
authors.forename: Noboru
authors.initials: N
authors.lastname: Mesaki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kono
authors.forename: Takao
authors.initials: T
authors.lastname: Akama
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000097:blood / Q000276:immunology; D005260:Female; D006615:Hip / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007866:Leg / Q000502:physiology; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D052580:Muscle Stretching Exercises; D010807:Physical Endurance / Q000276:immunology / Q000502:physiology*; D055070:Resistance Training; D013601:T-Lymphocytes / Q000276:immunology*; D051197:Toll-Like Receptor 4 / Q000097:blood / Q000276:immunology
chemical_list: D015703:Antigens, CD; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4