title: The relationship between serum selenium concentration and neutrophil function in peripheral blood.
abstract: We evaluated the relationships between neutrophil-related functions and serum selenium (Se) concentration in the general population. We examined 800 subjects who had participated in the Iwaki Health Promotion Project in 2005 to determine the relationships between serum Se concentration and neutrophil-related functions such as the production capability of reactive oxygen species (ROS), phagocytic activity, and serum opsonic activity (SOA). In nonstimulated neutrophils, i.e., in neutrophils at their baseline condition before the application of the phagocytic stimulus, the serum Se concentration tends to be high and the ROS production tends to be low. With regard to SOA, there was a significant negative correlation between lucigenin-dependent chemiluminescence and serum Se concentration in both men and women. Moreover, in women, a significant negative correlation was observed between luminol-dependent chemiluminescence and serum Se concentration. These results suggest that subjects with a lower serum Se concentration may be exposed to a greater chronic oxidative stress due to neutrophil ROS production. In addition, the findings of our study suggest that women rather than men benefit more from Se against oxidative stress.
authors.affiliation: Department of Social Medicine, Hirosaki University Graduate School of Medicine, Zaifu-cho 5, Hirosaki, 036-8562, Aomori, Japan.
authors.forename: Sangun
authors.initials: S
authors.lastname: Lee
authors.forename: Ippei
authors.initials: I
authors.lastname: Takahashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Matsuzaka
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Yamai
authors.forename: Kazuma
authors.initials: K
authors.lastname: Danjo
authors.forename: Takako
authors.initials: T
authors.lastname: Kumagai
authors.forename: Takashi
authors.initials: T
authors.lastname: Umeda
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Itai
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Nakaji
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000097:blood; D001823:Body Composition; D015992:Body Mass Index; D002469:Cell Separation; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D008019:Life Style; D049449:Luminescence; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D009895:Opsonin Proteins / Q000097:blood; D018384:Oxidative Stress; D010587:Phagocytosis; D017382:Reactive Oxygen Species / Q000097:blood; D012643:Selenium / Q000097:blood*; D012727:Sex Characteristics; D012907:Smoking / Q000097:blood; D015054:Zymosan
chemical_list: D009895:Opsonin Proteins; D017382:Reactive Oxygen Species; D015054:Zymosan; D012643:Selenium