title: Neural mechanisms for filtering self-generated sensory signals in cerebellum-like circuits.
abstract: This review focuses on recent progress in understanding mechanisms for filtering self-generated sensory signals in cerebellum-like circuits in fish and mammals. Recent in vitro studies in weakly electric gymnotid fish have explored the interplay among anti-Hebbian plasticity, synaptic dynamics, and feedforward inhibition in canceling self-generated electrosensory inputs. Studies of the mammalian dorsal cochlear nucleus have revealed multimodal integration and anti-Hebbian plasticity, suggesting that this circuit may adaptively filter incoming auditory information. In vivo studies in weakly electric mormryid fish suggest a key role for granule cell coding in sensory filtering. The clear links between synaptic plasticity and systems level sensory filtering in cerebellum-like circuits may provide insights into hypothesized adaptive filtering functions of the cerebellum itself.
authors.affiliation: Department of Neuroscience and Kavli Institute for Brain Science, Columbia University Medical Center, New York, NY 10032, United States.
authors.forename: Tim
authors.initials: T
authors.lastname: Requarth
authors.forename: Nathaniel B
authors.initials: NB
authors.lastname: Sawtell
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000166:cytology* / Q000502:physiology*; D004555:Electric Fish / Q000502:physiology; D004557:Electric Organ / Q000166:cytology; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology*; D055139:Sensory Gating / Q000502:physiology*