title: [Japanese epidemiologic investigation for non-steroidal anti-inflammatory drugs-induced ulcers].
abstract: This review summaried epidemiologic investigation for non-steroidal anti-inflammatory drugs (NSAIDs)-induced ulcers to focus on the Japanese evidence. In Japan, national health insurance does not cover procedures that prevent or lower the risk for NSAIDs-induced ulcer. In NSAIDs treatment to patients with risk factors, it is desirable to administer antiulcer agents. However, in Japan, there are no large-scale studies on the efficacy of co-medication such as proton pump inhibitors, prostaglandin analogs (misoprostol) or histamine-H2 receptor antagonists or on the effectiveness of H. pylori eradication or selective COX-2 antagonists. In the future, large-scale clinical studies should be conducted to accumulate high quality evidence including cost-effectiveness and overall safety including cardiovascular events, because Japanese differ from Westerners in several genetical or acquired factors.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Miyake
authors.forename: Choitsu
authors.initials: C
authors.lastname: Sakamoto
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000453:epidemiology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal