title: Synthesis of Folic Acid Functionalized PLLA-b-PPEGMA Nanoparticles for Cancer Cell Targeting.
abstract: Poly(L-lactic acid)-block-poly(poly(ethylene glycol) monomethacrylate) (PLLA-b-PPEGMA) has been prepared by the ring-opening polymerization of lactide with a double-headed initiator, 2-hydroxyethyl 2'-methyl-2'-bromopropionate (HMBP), followed by atom transfer radical polymerization (ATRP) of poly(ethylene glycol) monomethacrylate (PEGMA). PLLA-b-PPEGMA nanoparticles with encapsulated Fe(3) O(4) are prepared by a solvent evaporation/extraction technique, and then further functionalized with folic acid, a cancer targeting ligand. Our results show that such functionalized PLLA-b-PPEGMA nanoparticles have good potential as carriers for targeted drug delivery in cancer treatment.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, 119260, Singapore.
authors.forename: Feixiong
authors.initials: F
authors.lastname: Hu
authors.forename: Koon Gee
authors.initials: KG
authors.lastname: Neoh
authors.forename: En-Tang
authors.initials: ET
authors.lastname: Kang