title: [Inhibitory effect of ferulic acid on inflammatory response in microglia induced by lipopolysaccharides].
abstract: Ferulic acid (FA) is a natural compound that expresses antioxidant and anti-inflammatory activities. Microglial cells are innate immune cells that reside within the central nervous system (CNS). Activated microglia mediated neuronal immunity contributes to the neurodegeneration associated with Alzheimer's disease. In this study, we investigated the inhibitory effect of FA on neuroinflammation in BV-2 microglial cells induced by lipopolysaccharides (LPS). Our study showed that FA significantly suppressed the production of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), and decreased induced type II nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein in LPS-stimulated BV-2 microglia cells in a dose dependent manner. We hypothesized that this was achieved by suppressing the protein level of Toll-like receptor 4 (TLR4).
authors.affiliation: Department of Pharmacology of Traditional Chinese Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China. hftxyy@yahoo.com.cn
authors.forename: Feng
authors.initials: F
authors.lastname: Huang
authors.forename: Hua-Ming
authors.initials: HM
authors.lastname: Deng
authors.forename: Miao-Miao
authors.initials: MM
authors.lastname: Zhu
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Zai-Jun
authors.initials: ZJ
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiao
authors.forename: Hong
authors.initials: H
authors.lastname: Nie
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000276:immunology*; D000818:Animals; D002460:Cell Line; D003373:Coumaric Acids / Q000494:pharmacology*; D015232:Dinoprostone / Q000276:immunology; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000276:immunology*; D052247:Nitric Oxide Synthase Type II / Q000276:immunology
chemical_list: D003373:Coumaric Acids; D008070:Lipopolysaccharides; C004999:ferulic acid; D052247:Nitric Oxide Synthase Type II; D015232:Dinoprostone