title: Synthesis of hydrogels based on poly(NIPAM) inserted into collagen sponge.
abstract: The study presents the preparation of a semi-synthetic hydrogel based on poly(N-isopropyl acrylamide-co-diethylene glycol diacrylate) inserted onto the collagen porous membrane. The synthesis of the hydrogels was performed through radical copolymerization of N-isopropyl acrylamide (NIPAM) with diethylene glycol diacrylate (DEGDA) also as crosslinking agent, using ammonium persulfate as initiator and N,N,N',N'-tetramethylethylene diamine as activator, and it was achieved in the presence of the collagen matrix. The prepared hydrogels were characterized by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy. The swelling behaviour of the semi-interpenetrated polymer network related on the hydrogel composition, it was also evaluated. The pore sizes of the synthesized hydrogels, much larger than the typical mesh size of a conventional hydrogel, allow to consider the hybrid hydrogel based on the inserted poly(NIPAM-co-DEGDA) onto collagen fibrils as a super-porous hydrogel.
authors.affiliation: Petru Poni Institute of Macromolecular Chemistry, Iasi, Romania.
authors.forename: Manuela-Tatiana
authors.initials: MT
authors.lastname: Nistor
authors.forename: Aurica P
authors.initials: AP
authors.lastname: Chiriac
authors.forename: Cornelia
authors.initials: C
authors.lastname: Vasile
authors.forename: Liliana
authors.initials: L
authors.lastname: Verestiuc
authors.forename: Loredana Elena
authors.initials: LE
authors.lastname: Nita
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000179:Acrylates / Q000737:chemistry; D001672:Biocompatible Materials / Q000032:analysis / Q000138:chemical synthesis*; D003094:Collagen / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D004337:Drug Carriers / Q000032:analysis / Q000138:chemical synthesis*; D019855:Ethylene Glycol / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000032:analysis / Q000138:chemical synthesis*; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D014945:Wound Healing
chemical_list: D000178:Acrylamides; D000179:Acrylates; D001672:Biocompatible Materials; D004337:Drug Carriers; D020100:Hydrogels; D003094:Collagen; C067295:N-isopropylacrylamide; D019855:Ethylene Glycol; C036658:acrylic acid