title: Pregabalin assay in a patient with widespread neuropathic pain and late onset gluten intolerance.
abstract: OBJECTIVE
  The aim of this study was to determine the pharmacokinetics of pregabalin in a patient with malabsorption secondary to celiac disease and compare the findings with the data available from pre-existing studies in healthy volunteer controls.
  
  
  METHODS
  A 39-year-old man consented to a 24-hour pregabalin assay with sequential pre and post-dose blood sampling.
  
  
  RESULTS
  The blood levels measured in this subject were no different to healthy male volunteers enrolled in previous studies.
  
  
  CONCLUSIONS
  Although the results obtained are encouraging, the wide spectrum of effects and interactions of various drugs in malabsorption would suggest that therapy of any kind should be considered at individual level and monitored with blood assays.
authors.affiliation: Pain Unit, University Hospital Birmingham, Birmingham, UK. dalli@easynet.co.uk
authors.forename: Dalvina E
authors.initials: DE
authors.lastname: Hanu-Cernat
authors.forename: Alex N
authors.initials: AN
authors.lastname: Phipps
authors.forename: Jon H
authors.initials: JH
authors.lastname: Raphael
mesh_terms: D000328:Adult; D000700:Analgesics / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D000818:Animals; D002446:Celiac Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid