title: Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents.
abstract: Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25-12.5μg/mL against Mycobacterium tuberculosis H(37)Rv.
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Punjab, India.
authors.forename: G
authors.initials: G
authors.lastname: Mugunthan
authors.forename: Dharmarajan
authors.initials: D
authors.lastname: Sriram
authors.forename: Perumal
authors.initials: P
authors.lastname: Yogeeswari
authors.forename: K P
authors.initials: KP
authors.lastname: Ravindranathan Kartha
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D009593:Nitroimidazoles