title: [The apoptosis inhibitor survivin in transitional cell carcinoma of the urinary bladder].
abstract: Whether the expression of the apoptosis inhibitor survivin was correlated with the degree of differentiation and the stage of transitional cell carcinoma of the urinary bladder was studied. Sixty samples of surgical specimens from patients with urothelial carcinomas of various degrees of differentiation and different stages were examined. An immunohistochemical study using the monoclonal antibodies obtained by the authors was conducted. The high expression of survivin was shown to be correlated with the lower-grade differentiation of a tumor and its higher stage.
authors.forename: O M
authors.initials: OM
authors.lastname: Vol'pina
authors.forename: L E
authors.initials: LE
authors.lastname: Zavalishina
authors.forename: T D
authors.initials: TD
authors.lastname: Volkova
authors.forename: E V
authors.initials: EV
authors.lastname: Akhidova
authors.forename: D O
authors.initials: DO
authors.lastname: Koroev
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Andreeva
authors.forename: A N
authors.initials: AN
authors.lastname: Petrov
authors.forename: G A
authors.initials: GA
authors.lastname: Frank
mesh_terms: D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002295:Carcinoma, Transitional Cell / Q000378:metabolism / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D000077022:Survivin; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin