title: Haemolytic disease of the newborn due to anti-c.
abstract: Anti-D isoimmunisation remains the most common cause of erythroblastosis fetalis. Whereas most clinically significant blood group sensitisations noted during pregnancy are still secondary to anti-D incompatibility, sensitisation to antigens other than D in the CDE system is not uncommon and can cause severe disease. The widespread use of Rh-D immune globulin has led to a relative increase in the importance of non-Rh-D isoimmunisation as a cause of haemolytic disease of the newborn. We report the case of a baby with severe hyperbilirubinaemia and persistent anaemia due to anti-c isoimmunisation with a high-titre maternal c antibody. The baby required emergency transfusion and intensive phototherapy. The medical literature relating to maternal c isoimmunisation and neonatal outcome is also reviewed. Because of its ability to cause clinically significant haemolytic disease of the newborn, practitioners must manage anti-c isoimmunisation in a manner similar to that for anti-D.
authors.affiliation: University Hospital Hassan II, Department of Neonatology, Service de Pédiatrie, CHU Hassan II, Fez, 30 000, Morocco.
authors.forename: Sana
authors.initials: S
authors.lastname: Abourazzak
authors.forename: Safae
authors.initials: S
authors.lastname: Hajjaj
authors.forename: Chekabab
authors.initials: C
authors.lastname: Hakima
authors.forename: Abdelhak
authors.initials: A
authors.lastname: Bouharrou
authors.forename: Moustapha
authors.initials: M
authors.lastname: Hida