title: HER2 testing in the UK: recommendations for breast and gastric in-situ hybridisation methods.
abstract: These guidelines supplement existing guidelines on HER2 testing by immunohistochemistry and in-situ hybridisation(ISH) methods in the UK. They provide a specific focus on aspects of guidance relevant to HER2 ISH testing methods, both fluorescent and chromogenic. They are formulated to give advice on methodology, interpretation and quality control for ISH-based testing of HER2 status in common tumour types, including both breast and gastric tumours. The aim is to ensure that all ISH-based testing is accurate, reliable and timely.
authors.affiliation: Endocrine Cancer Group, Edinburgh, UK. john.bartlett@oicr.on.ca
authors.forename: J M S
authors.initials: JM
authors.lastname: Bartlett
authors.forename: J
authors.initials: J
authors.lastname: Starczynski
authors.forename: Neil
authors.initials: N
authors.lastname: Atkey
authors.forename: E
authors.initials: E
authors.lastname: Kay
authors.forename: A
authors.initials: A
authors.lastname: O'Grady
authors.forename: Michael
authors.initials: M
authors.lastname: Gandy
authors.forename: Merdol
authors.initials: M
authors.lastname: Ibrahim
authors.forename: Bharat
authors.initials: B
authors.lastname: Jasani
authors.forename: I O
authors.initials: IO
authors.lastname: Ellis
authors.forename: S E
authors.initials: SE
authors.lastname: Pinder
authors.forename: R A
authors.initials: RA
authors.lastname: Walker
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D018734:Genes, erbB-2; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods* / Q000592:standards; D007318:Inservice Training; D008503:Medical Staff / Q000193:education; D015336:Molecular Probe Techniques; D011785:Quality Assurance, Health Care; D011786:Quality Control; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D012107:Research Design; D013048:Specimen Handling; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000235:genetics
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases