title: Rapid decline in glomerular filtration rate during the first weeks following heart transplantation.
abstract: We hypothesized that a decrease in renal function is seen immediately after heart transplantation (HTX) with little recovery over time. Twelve consecutive patients had their glomerular filtration rate (GFR) measured using (51)Cr-ethylenediaminetetraacetic acid (EDTA) measured GFR (mGFR) before transplantation and at 1, 2, 3, and 26 weeks after transplantation. The mGFR decreased by 28% and 24% during the first 3 and 26 weeks, respectively, with mean blood cyclosporine concentration as an independent risk factor for the decrease in mGFR. The identification of cyclosporine A (CsA) as the most important risk factor for the rapid and sustained decrease in renal function supports the need for more studies on renoprotective strategies immediately after HTX.
authors.affiliation: Department of Nephrology P 2131, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Hornum
authors.forename: M
authors.initials: M
authors.lastname: Andersen
authors.forename: F
authors.initials: F
authors.lastname: Gustafsson
authors.forename: P
authors.initials: P
authors.lastname: Oturai
authors.forename: K
authors.initials: K
authors.lastname: Sander
authors.forename: S A
authors.initials: SA
authors.lastname: Mortensen
authors.forename: B
authors.initials: B
authors.lastname: Feldt-Rasmussen
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000097:blood; D004492:Edetic Acid; D005919:Glomerular Filtration Rate; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D004492:Edetic Acid