title: Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss.
abstract: An impaired cochlear perfusion seems to be an important etiopathogenetic event in idiopathic sudden sensorineural hearing loss (ISSNHL). Recently, oxidative stress has been proposed as risk factors of microvascular damage. This observational study aimed to evaluate the possible role of oxidative stress in ISSNHL. In thirty-nine ISSNHL patients and seventy healthy subjects serum reactive oxygen species concentrations (ROS) and total antioxidant capacity (TAC) were measured by spectrophotometric methods on F.R.E.E. analyzer (Diacron International, Italy). Moreover, a global oxidative stress index (Oxidative-INDEX), reflecting both oxidative and antioxidant counterparts, was also calculated. 25/39 patients showed oxidative stress due to ROS levels significantly higher than controls (348.2 ± 84.8 vs. 306.75 ± 46.7 UCarr; p = 0.001). The Oxidative-INDEX was significantly higher in patients than in controls (0.75 ± 2.4 vs. -0.0007 ± 1.28 AU, p = 0.03). As oxidative stress is a key determinant in endothelial dysfunction, our findings could suggest vascular impairment involvement in ISSNHL etiopathogenesis.
authors.affiliation: Dipartimento di Scienze Specialistiche e Chirurgiche, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Capaccio
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Pignataro
authors.forename: Lorenzo M
authors.initials: LM
authors.lastname: Gaini
authors.forename: Paolo E
authors.initials: PE
authors.lastname: Sigismund
authors.forename: Cristina
authors.initials: C
authors.lastname: Novembrino
authors.forename: Rachele
authors.initials: R
authors.lastname: De Giuseppe
authors.forename: Valentina
authors.initials: V
authors.lastname: Uva
authors.forename: Armando
authors.initials: A
authors.lastname: Tripodi
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Bamonti
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D001309:Auditory Threshold / Q000502:physiology; D003051:Cochlea / Q000098:blood supply; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D003639:Hearing Loss, Sudden / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000097:blood; D012307:Risk Factors
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species