title: Regioselective synthesis of tetrahydrothiochromen-5-ones via a one-pot three-component solvent-free domino protocol.
abstract: A highly efficient one-pot three-component regioselective synthesis of 4-aryl-3-aroyl-2-methylsulfanyl-4,6,7,8-tetrahydrothiochromen-5-ones has been developed by annulation of β-oxodithioesters with aldehydes and cyclic 1,3-diketones under solvent-free conditions promoted by P(2)O(5). No cocatalyst or activator is needed in this protocol. The merit of this process is highlighted by its high efficiency of producing three new bonds and a stereocenter in one operation.
authors.affiliation: Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi-221005, India.
authors.forename: Sushobhan
authors.initials: S
authors.lastname: Chowdhury
authors.forename: Ganesh Chandra
authors.initials: GC
authors.lastname: Nandi
authors.forename: Subhasis
authors.initials: S
authors.lastname: Samai
authors.forename: Maya Shankar
authors.initials: MS
authors.lastname: Singh