title: Metall(prote)omic studies by capillary electrophoresis using separation capillary as an in-line reactor.
abstract: This perspective article highlights the potential of capillary electrophoresis (CE) in in-line monitoring of biomolecular reactions related to in vivo transformations of metal species. In such scrutinizing, the capillary is regarded as a nanolitre-volume reactor in which electrical field-driven reactants are mixed to produce a response that enables in situ following-up and characterization of non-covalent molecular interactions. The concept of a CE reactor has been extended here to the investigation of processes that are responsible for the formation and decomposition of metal-bioligand species under simulated physiological conditions.
authors.affiliation: Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Kosygin St. 19, 119991, Moscow, Russia. andrei.timerbaev@univie.ac.at
authors.forename: Andrei R
authors.initials: AR
authors.lastname: Timerbaev
authors.forename: Lidia S
authors.initials: LS
authors.lastname: Foteeva
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Pawlak
authors.forename: Maciej
authors.initials: M
authors.lastname: Jarosz
mesh_terms: D000818:Animals; D019075:Electrophoresis, Capillary / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D007700:Kinetics; D008024:Ligands; D008670:Metals / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D013054:Spectrophotometry, Atomic
chemical_list: D008024:Ligands; D008670:Metals