title: Pigment epithelium-derived factor: a not so sympathetic regulator of insulin resistance?
abstract: Pigment epithelium-derived factor (PEDF), an adipokine, is a regulator of oxidative stress, inflammation, angiogenesis, and insulin sensitivity. Contrary to animal and cell culture data, inhibition of the sympathoadrenal system does not affect serum PEDF in humans. However, during acute beta-adrenergic receptor stimulation serum PEDF concentration is decreased. PEDF may be involved in cross talk between adipose tissue and skeletal muscle.
authors.affiliation: Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523-1582, USA. christopher.bell@colostate.edu
authors.forename: Christopher
authors.initials: C
authors.lastname: Bell
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D005136:Eye Proteins / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D018482:Muscle, Skeletal / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000097:blood*; D020239:Receptor Cross-Talk; D015843:Serpins / Q000097:blood*; D013564:Sympathetic Nervous System / Q000502:physiology; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor