title: Association of CD209 polymorphisms with tuberculosis in an Indonesian population.
abstract: Tuberculosis (TB) caused by Mycobacterium tuberculosis is a major cause of morbidity and mortality worldwide. Thus far, many candidate genes have been investigated for their possible association with TB. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) encoded by CD209 is the major receptor of M tuberculosis on human dendritic cells. Previous studies reported inconsistent results on the association between CD209 polymorphisms and TB. We examined whether 9 single nucleotide polymorphisms (SNPs) of CD209 are associated with TB in 2 southeast Asian populations (Indonesian and Vietnamese) by Fisher's exact test. The SNP at -939 in the promoter region exhibited a significant association with TB in Indonesian (GG vs GA + AA, p = 0.0051, odds ratio [OR] = 0.68, 95% confidence interval [CI] = 0.52-0.89) but not in Vietnamese populations. Further extensive studies are required to confirm the contribution of CD209 polymorphisms to TB susceptibility.
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Rika
authors.initials: R
authors.lastname: Yuliwulandari
authors.forename: Hideki
authors.initials: H
authors.lastname: Yanai
authors.forename: Luu Thi
authors.initials: LT
authors.lastname: Lien
authors.forename: Nguyen Thi Le
authors.initials: NT
authors.lastname: Hang
authors.forename: Minako
authors.initials: M
authors.lastname: Hijikata
authors.forename: Naoto
authors.initials: N
authors.lastname: Keicho
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D056726:Genetic Association Studies; D060005:Genotyping Techniques; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D037181:Lectins, C-Type / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000472:pathogenicity; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D014744:Vietnam / Q000208:ethnology; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin