title: Real-time full field laser Doppler imaging.
abstract: We present a full field laser Doppler imaging instrument, which enables real-time in vivo assessment of blood flow in dermal tissue and skin. This instrument monitors the blood perfusion in an area of about 50 cm(2) with 480 × 480 pixels per frame at a rate of 12-14 frames per second. Smaller frames can be monitored at much higher frame rates. We recorded the microcirculation in healthy skin before, during and after arterial occlusion. In initial clinical case studies, we imaged the microcirculation in burned skin and monitored the recovery of blood flow in a skin flap during reconstructive surgery indicating the high potential of LDI for clinical applications. Small animal imaging in mouse ears clearly revealed the network of blood vessels and the corresponding blood perfusion.
authors.forename: Marcel
authors.initials: M
authors.lastname: Leutenegger
authors.forename: Erica
authors.initials: E
authors.lastname: Martin-Williams
authors.forename: Pascal
authors.initials: P
authors.lastname: Harbi
authors.forename: Tyler
authors.initials: T
authors.lastname: Thacher
authors.forename: Wassim
authors.initials: W
authors.lastname: Raffoul
authors.forename: Marc
authors.initials: M
authors.lastname: André
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez
authors.forename: Philippe
authors.initials: P
authors.lastname: Lasser
authors.forename: Theo
authors.initials: T
authors.lastname: Lasser