title: Liver transplantation is possible in some patients with liver metastasis of colon cancer.
abstract: Liver metastases from colorectal cancer are an absolute contraindication for liver transplantation. Aggressive therapy with liver resection and local chemotherapy in selected patients may be able to provide long-term cure. Given the risks of tumor recurrence, whether patients with post chemotherapy complications leading to liver failure should be offered transplantation is a challenging question in an era of limited organ availability. Herein we have presented 2 cases of liver transplantation performed in patients with colorectal cancer metastases treated with liver resection followed by hepatic artery infusion chemotherapy leading to development of sclerosing cholangitis and eventual liver failure. This report demonstrates that liver transplantation may be an option in selected patients with colorectal cancer liver metastases that have been well treated.
authors.affiliation: Division of Liver Diseases, The Mount Sinai Hospital, Recanati-Miller Transplantation Institute, New York, NY, USA.
authors.forename: O
authors.initials: O
authors.lastname: Uskudar
authors.forename: K
authors.initials: K
authors.lastname: Raja
authors.forename: T D
authors.initials: TD
authors.lastname: Schiano
authors.forename: M I
authors.initials: MI
authors.lastname: Fiel
authors.forename: J
authors.initials: J
authors.lastname: del Rio Martin
authors.forename: C
authors.initials: C
authors.lastname: Chang
mesh_terms: D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged