title: D-(+)-galactose-conjugated single-walled carbon nanotubes as new chemical probes for electrochemical biosensors for the cancer marker galectin-3.
abstract: D-(+)-Galactose-conjugated single-walled carbon nanotubes (SWCNTs) were synthesized for use as biosensors to detect the cancer marker galectin-3. To investigate the binding of galectin-3 to the d-(+)-galactose-conjugated SWCNTs, an electrochemical biosensor was fabricated by using molybdenum electrodes. The binding affinities of the conjugated SWCNTs to galectin-3 were quantified using electrochemical sensitivity measurements based on the differences in resistance together with typical I-V characterization. The electrochemical sensitivity measurements of the d-(+)-galactose-conjugated SWCNTs differed significantly between the samples with and without galectin-3. This indicates that d-(+)-galactose-conjugated SWCNTs are potentially useful electrochemical biosensors for the detection of cancer marker galectin-3.
authors.affiliation: Department of Nano System Engineering, Inje University, Gimhae, 612-749, Korea; E-Mails: immergreen@dreamwiz.com (Y.K.P.); bayarma_sbmt@yahoo.com (B.B.); wlee@inje.ac.kr (W.K.L.); mjeon@inje.ac.kr (M.H.J.).
authors.forename: Young Kum
authors.initials: YK
authors.lastname: Park
authors.forename: Bayarmaa
authors.initials: B
authors.lastname: Bold
authors.forename: Woo Kyung
authors.initials: WK
authors.lastname: Lee
authors.forename: Min Hyon
authors.initials: MH
authors.lastname: Jeon
authors.forename: Kay Hyeok
authors.initials: KH
authors.lastname: An
authors.forename: Seung Yol
authors.initials: SY
authors.lastname: Jeong
authors.forename: Young Key
authors.initials: YK
authors.lastname: Shim
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D015374:Biosensing Techniques; D055664:Electrochemical Techniques; D005690:Galactose / Q000737:chemistry*; D037502:Galectin 3 / Q000032:analysis*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D037502:Galectin 3; D037742:Nanotubes, Carbon; D005690:Galactose