title: Effect of graphite concentration on shear-wave speed in gelatin-based tissue-mimicking phantoms.
abstract: Elasticity-based imaging modalities are becoming popular diagnostic tools in clinical practice. Gelatin-based, tissue mimicking phantoms that contain graphite as the acoustic scattering material are commonly used in testing and validating elasticity-imaging methods to quantify tissue stiffness. The gelatin bloom strength and concentration are used to control phantom stiffness. While it is known that graphite concentration can be modulated to control acoustic attenuation, the impact of graphite concentration on phantom elasticity has not been characterized in these gelatin phantoms. This work investigates the impact of graphite concentration on phantom shear stiffness as characterized by shear-wave speed measurements using impulsive acoustic-radiation-force excitations. Phantom shear-wave speed increased by 0.83 (m/s)/(dB/(cm MHz)) when increasing the attenuation coefficient slope of the phantom material through increasing graphite concentration. Therefore, gelatin-phantom stiffness can be affected by the conventional ways that attenuation is modulated through graphite concentration in these phantoms.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: Pamela G
authors.initials: PG
authors.lastname: Anderson
authors.forename: Ned C
authors.initials: NC
authors.lastname: Rouze
authors.forename: Mark L
authors.initials: ML
authors.lastname: Palmeri
mesh_terms: D000465:Algorithms; D054459:Elasticity Imaging Techniques / Q000379:methods*; D004867:Equipment Design; D005780:Gelatin / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D008422:Materials Testing; D019047:Phantoms, Imaging
chemical_list: D006108:Graphite; D005780:Gelatin