title: An updated GA signaling 'relief of repression' regulatory model.
abstract: Gibberellic acid (GA) regulates many aspects of plant growth and development. The DELLA proteins act to restrain plant growth, and GA relieves this repression by promoting their degradation via the 26S proteasome pathway. The elucidation of the crystalline structure of the GA soluble receptor GID1 protein represents an important breakthrough for understanding the way in which GA is perceived and how it induces the destabilization of the DELLA proteins. Recent advances have revealed that the DELLA proteins are involved in protein-protein interactions within various environmental and hormone signaling pathways. In this review, we highlight our current understanding of the 'relief of repression' model that aims to explain the role of GA and the function of the DELLA proteins, incorporating the many aspects of cross-talk shown to exist in the control of plant development and the response to stress.
authors.affiliation: State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: Gao
authors.forename: Sen-Lin
authors.initials: SL
authors.lastname: Xiao
authors.forename: Qin-Fang
authors.initials: QF
authors.lastname: Yao
authors.forename: Yu-Juan
authors.initials: YJ
authors.lastname: Wang
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Fu
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D015536:Down-Regulation; D018506:Gene Expression Regulation, Plant; D005875:Gibberellins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D005875:Gibberellins; C007842:gibberellic acid