title: Enantioselective Evans-Tishchenko reduction of β-hydroxyketone catalyzed by lithium binaphtholate.
abstract: Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral β-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic β-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manner.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ichibakase
authors.forename: Masato
authors.initials: M
authors.lastname: Nakatsu
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakajima
mesh_terms: D002384:Catalysis; D007659:Ketones / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D008094:Lithium / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D008094:Lithium