title: Measurement of intraocular and intracranial pressure: is there a relationship?
abstract: OBJECTIVE
  To study whether noninvasive, intraocular pressure (IOP) measurements significantly correlate with standard intracranial pressure (ICP) measurements.
  
  
  METHODS
  This prospective, blinded study enrolled 46 patients who were undergoing medically indicated lumbar puncture (LP). IOP was measured by applanation tonometry immediately prior to measuring LP opening pressure. One patient was excluded due to unsuccessful ICP measurement.
  
  
  RESULTS
  In the 45 patients to successfully undergo IOP and ICP measurement, there was no significant relationship between ICP and average IOP for both eyes (r = -0.005). There was no significant relationship between ICP and IOP in either eye, when studied individually(r = 0.03 ocular dexter [OD], r = -0.05 ocular sinister [OS]). There was no significant relationship between ICP and IOP when the eye best correlated to the patient's ICP was chosen (r = -0.01).
  
  
  CONCLUSIONS
  No significant relationship between ICP and IOP was observed. Noninvasive IOP measurements do not predict ICP.
authors.affiliation: Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS 39216, USA. tkirk@umc.edu
authors.forename: Tyler
authors.initials: T
authors.lastname: Kirk
authors.forename: Keith
authors.initials: K
authors.lastname: Jones
authors.forename: Spencer
authors.initials: S
authors.lastname: Miller
authors.forename: James
authors.initials: J
authors.lastname: Corbett
mesh_terms: D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D007429:Intraocular Pressure / Q000502:physiology*; D011446:Prospective Studies; D013129:Spinal Puncture; D013223:Statistics as Topic; D014065:Tonometry, Ocular