title: Homogeneous diffusion layer model of dissolution incorporating the initial transient phase.
abstract: Purpose of this paper is to describe characteristic features of dissolution data by using homogeneous model of dissolution with initial transient phase. To achieve the goal we consider a random lag time before the homogeneous phase of the dissolution begins. The resulting dissolution profiles are characterized by sigmoidal shape commonly observed in empirical dissolution data. Furthermore, probability distribution of repeated measurements at fixed time is deduced from the model and function describing variability of the data in dependency on time is proposed. Three examples with normal, exponential and gamma probability distribution of the lag time are presented. All the models are pairwise compared with the Weibull function with high similarity between them. The result offers an alternative interpretation for the frequently found fit of the Weibull model to experimental data.
authors.affiliation: Department of Mathematics and Statistics, Masaryk University, Kotlarska 2, Brno, Czech Republic. cupera@ics.muni.cz
authors.forename: Jakub
authors.initials: J
authors.lastname: Cupera
authors.forename: Petr
authors.initials: P
authors.lastname: Lansky
mesh_terms: D004058:Diffusion; D008956:Models, Chemical; D015233:Models, Statistical; D044367:Phase Transition; D012995:Solubility; D013607:Tablets / Q000737:chemistry*; D013997:Time Factors
chemical_list: D013607:Tablets