title: Detection of viral nucleoprotein binding to anti-influenza aptamers via SERS.
abstract: A highly sensitive surface-enhanced Raman (SERS)-based method for detection of influenza viral nucleoproteins is described. The intrinsic SERS spectrum of the aptamer-nucleoprotein complex provides direct evidence of binding between a polyvalent anti-influenza aptamer and the nucleoproteins of three influenza strains.
authors.affiliation: Department of Chemistry, University of Georgia, Athens, GA 30602, USA. pnegri@uga.edu
authors.forename: Pierre
authors.initials: P
authors.lastname: Negri
authors.forename: Andreas
authors.initials: A
authors.lastname: Kage
authors.forename: Andreas
authors.initials: A
authors.lastname: Nitsche
authors.forename: Dieter
authors.initials: D
authors.lastname: Naumann
authors.forename: Richard A
authors.initials: RA
authors.lastname: Dluhy
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry; D009698:Nucleoproteins / Q000032:analysis*; D009975:Orthomyxoviridae / Q000378:metabolism*; D011485:Protein Binding; D013059:Spectrum Analysis, Raman / Q000379:methods*; D014764:Viral Proteins / Q000032:analysis*
chemical_list: D052157:Aptamers, Nucleotide; D009698:Nucleoproteins; D014764:Viral Proteins; D006046:Gold