title: Raltegravir in combination with other antiretroviral agents for the treatment of HIV infection.
abstract: Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unusual given its recent availability, but resistance with identified viral mutation pathways in the integrase gene in patients receiving the drug does occur.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Stony Brook University Medical Center, Stony Brook, New York, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Chirch
authors.forename: Roy T
authors.initials: RT
authors.lastname: Steigbigel