title: [When to think about Crohn's disease when facing with chronic abdominal pain in children and adolescents?].
abstract: Crohn's disease (CD) together with ulcerative colitis (UC) and indeterminate colitis (IC) are the so called inflammatory bowel diseases (IBD). Epidemiological data show an increased incidence of both UC and CD and, especially in North America and in Europe, an increased prevalence of CD. European data show that northern countries present higher rates of IBD than southern ones. It is estimated that 15%-20% of CD patients experience onset of their symptoms under 20 years of age. An increasing number of children enter disease before 8 years of age. The pathogenesis of CD has became more documented involving both the immune system and changes in intestinal microbiota. Chronic abdominal pain associated with failure to thrive and inflammatory syndrome with or without intestinal transit disorders suggest CD. Onset of a anoperineal disease is also suggestive of CD and is a severity sign. The diagnosis is based on clinical history, physical examination, radiological studies, endoscopy, and histology. CD is defined by evidence of a discontinuous chronic inflammation of the gastrointestinal tract with or without granulomas and supported by clinical, biochemical, and radiological evidence. Treatment aims to reducing inflammation and restauring growth. Enteral feeding has become a key issue in allowing to avoid steroids. Immunosuppressive treatment based on azathioprine is increasingly used for maintaining remission. Anti-TNF treatment is a rescue therapy in case of refractory, frequently relapsing disease especially those with ano-perineal disease.
authors.affiliation: Service de gastroentérologie, hépatologie et nutrition pédiatriques, hôpital Necker-Enfants malades, 75015 Paris. olivier.goulet@nck.aphp.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Goulet
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis*; D006801:Humans