title: MSTN mRNA after varying exercise modalities in humans.
abstract: The aim of this study was to examine the effects of strength and endurance training on myostatin mRNA in the vastus lateralis muscle of healthy and physically active humans. 21 healthy and physically active sports students (static and dynamic knee extensor strength 33 ± 4.5 N/kgBW; 1 185 ± 170 W, respectively; maximum oxygen uptake 52.5 ± 8 ml/kgBW/min) were recruited and randomly assigned to a moderate endurance training group (n=7), a strength training group (n=7) and a control group (n=7). Muscle biopsies were taken from the vastus lateralis muscle 3-5 days before the start as well as at the end of the 12 weeks' training period. Exercise-specific functional improvements after moderate endurance training and strength training were measured for submaximal endurance and for static and dynamic strength of the knee extensor muscles. None of the myostatin mRNA values showed significant pre-post differences or group-specific differences. These results are in contrast to data with sedentary subjects, suggesting that myostatin is necessary for adaptations of skeletal muscle to exercise stress. We conclude that functional improvements after moderate endurance training and strength training can occur without alterations in myostatin mRNA in physically active humans.
authors.affiliation: German Sport University Cologne, Outpatient Clinic for Sports Traumatology and Public Health Consultation, Cologne, Germany. t.schiff er@dshs-koeln.de
authors.forename: T
authors.initials: T
authors.lastname: Schiffer
authors.forename: S
authors.initials: S
authors.lastname: Geisler
authors.forename: B
authors.initials: B
authors.lastname: Sperlich
authors.forename: H K
authors.initials: HK
authors.lastname: Strüder
mesh_terms: D001706:Biopsy; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007719:Knee Joint / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology; D055435:Myostatin / Q000235:genetics*; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D055070:Resistance Training / Q000379:methods*; D055815:Young Adult
chemical_list: D055435:Myostatin; D012333:RNA, Messenger