title: Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer.
abstract: BACKGROUND
  Early detection of pharyngeal cancer has been difficult. We reported that narrow-band imaging (NBI) endoscopy can detect superficial pharyngeal cancer, and these lesions can be treated endoscopically.
  
  
  OBJECTIVE
  To assess the safety and long-term efficacy of transoral organ-preserving pharyngeal endoscopic resection (TOPER) for superficial pharyngeal cancer.
  
  
  METHODS
  Retrospective 2-center cohort study.
  
  
  METHODS
  The study included 104 consecutive patients with superficial pharyngeal cancer.
  
  
  METHODS
  TOPER with the patients under general anesthesia.
  
  
  METHODS
  Safety of the procedure, long-term survival, clinical outcome.
  
  
  RESULTS
  A total of 148 consecutive lesions were resected in 104 patients. There was no severe adverse event. Temporary tracheostomy was required in 17 patients (16%) to prevent airway obstruction. The median fasting period and hospital stay after TOPER were 2 days (range 1-20 days) and 8 days (range 3-58 days), respectively. Ninety-six patients (92%) had no local recurrence or distant metastases. Local recurrence at the primary site developed in 6 patients, but all were resolved by repeat TOPER. With a median follow-up period of 43 months (range 3-96 months), the overall survival rate at 5 years was 71% (95% CI, 59-82). Cause-specific survival rate at 5 years was 97% (95% CI, 93-100). The cumulative development rate of multiple cancers in pharyngeal mucosal sites at 5 years was 22% (95% CI, 12-33). The pharynx was preserved in all patients, and they experienced no loss of function.
  
  
  CONCLUSIONS
  Retrospective design.
  
  
  CONCLUSIONS
  Peroral endoscopic resection of superficial pharyngeal cancer is a feasible and effective treatment with curative intent.
authors.affiliation: Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Muto
authors.forename: Hironaga
authors.initials: H
authors.lastname: Satake
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yano
authors.forename: Keiko
authors.initials: K
authors.lastname: Minashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Hayashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujii
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ochiai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohtsu
authors.forename: Shuko
authors.initials: S
authors.lastname: Morita
authors.forename: Takahiro
authors.initials: T
authors.lastname: Horimatsu
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Ezoe
authors.forename: Shinichi
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Ryo
authors.initials: R
authors.lastname: Asato
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tateya
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshizawa
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Chiba
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D016099:Endoscopy, Gastrointestinal; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D059351:Organ Sparing Treatments; D010610:Pharyngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D013997:Time Factors