title: [The first experience of external quality control of immunohistochemical studies in the diagnosis of lymphoproliferative diseases].
abstract: The paper presents the results of estimating the quality of immunohistochemical (IHC) staining in 36 pathologic laboratories of the Russian Federation. The results of IHC stains were assessed in 17 markers (CD3, CD5, CDIO, CD15, CD20, CD23, CD30, Bcl2, Bcl6, Pax5, TdT, Mum1, Cyclin D1, Ki-67, Kappa, Lambda, ALK), which are frequently used in the diagnosis of lymphoproliferative diseases, in the sections of specially formed tissue matrices. The study conducted in most participating laboratories has revealed the considerable IHC staining technology flaws that can critically affect the quality of diagnosis of lymphoproliferative diseases; the diagnostic capacities of some participating laboratories are inconsistent with the solved problems for a number of key antibodies being unavailable.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Krivolapov
authors.forename: M V
authors.initials: MV
authors.lastname: Peshkov
authors.forename: E E
authors.initials: EE
authors.lastname: Leenman
authors.forename: A E
authors.initials: AE
authors.lastname: Matsionis
authors.forename: A M
authors.initials: AM
authors.lastname: Kovrigina
mesh_terms: D015415:Biomarkers / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry / Q000592:standards*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000473:pathology; D011786:Quality Control; D012426:Russia
chemical_list: D015415:Biomarkers