title: Assessment of linear-scale indices for perimetry in terms of progression in early glaucoma.
abstract: Currently, global indices that summarize the visual field combine sensitivities on a logarithmic (decibel) scale. Recent structure-function models for glaucoma suggest that contrast sensitivity should be converted to a linear scale before averaging across visual field locations, to better relate sensitivity with the number of surviving retinal ganglion cells (RGCs). New indices designed to represent the number of RGCs already lost are described. At least one was found to be a significantly better predictor of subsequent rate of change than traditional Mean Deviation (p=0.014) in participants with glaucomatous optic neuropathy. Issues concerning the creation of optimal global indices are discussed.
authors.affiliation: Discoveries in Sight Laboratories, Devers Eye Institute, Legacy Health, Portland, OR 97232, USA. sgardiner@deverseye.org
authors.forename: Stuart K
authors.initials: SK
authors.lastname: Gardiner
authors.forename: Shaban
authors.initials: S
authors.lastname: Demirel
authors.forename: Chris A
authors.initials: CA
authors.lastname: Johnson
authors.forename: William H
authors.initials: WH
authors.lastname: Swanson
mesh_terms: D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000473:pathology / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D058609:Visual Field Tests; D014794:Visual Fields