title: New water-soluble Mn-porphyrin with catalytic activity for superoxide dismutation and peroxynitrite decomposition.
abstract: We have synthesized a new water-soluble cationic Mn-porphyrin with catalytic activity for both superoxide dismutation and peroxynitrite decomposition. The resulting Mn-porphyrin also showed higher stability for reactive oxygen species such as hydrogen peroxide and lower cytotoxicity, when compared with a control normal Mn-porphyrin. Furthermore, the new porphyrin recovered the viability of lipopolysaccharide-stimulated macrophage RAW 264.7 cells but the control Mn-porphyrin did not.
authors.affiliation: Department of Applied Chemistry, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Asayama
authors.forename: Takumi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kawakami
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D002384:Catalysis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000737:chemistry; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008345:Manganese / Q000737:chemistry*; D008665:Metalloporphyrins / Q000737:chemistry*; D051379:Mice; D030421:Peroxynitrous Acid / Q000737:chemistry*; D012995:Solubility / Q000187:drug effects; D013481:Superoxides / Q000737:chemistry*; D013997:Time Factors; D014867:Water / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D008070:Lipopolysaccharides; D008665:Metalloporphyrins; D014867:Water; D013481:Superoxides; D030421:Peroxynitrous Acid; D008345:Manganese; D006861:Hydrogen Peroxide; D001205:Ascorbic Acid