title: Radical vaginal trachelectomy (RVT) combined with laparoscopic lymphadenectomy: prospective study of 225 patients with early-stage cervical cancer.
abstract: OBJECTIVE
  The aim of the study was to prove the surgical and oncological safety of radical vaginal trachelectomy (RVT) and laparoscopic lymphadenectomy for patients with early-stage cervical cancer who are seeking parenthood.
  
  
  METHODS
  A database of 225 patients with early-stage cervical cancer and intention to treat by RVT after laparoscopic lymphadenectomy was prospectively maintained. A total of 212 patients were treated according to the protocol. The procedure was preformed in a standardized manner, and life table analysis was applied.
  
  
  RESULTS
  In the cohort of patients treated according to protocol, 8 recurrences occurred and 4 patients died from recurrence. The median follow-up time was 37 months (range, 0-171 months). The 5-year recurrence-free and overall survival was 94.4% and 97.4%, respectively. Perioperative and short-term postoperative complications were rare (2.8% and 7.5%, respectively). No severe long-term complications occurred.
  
  
  CONCLUSIONS
  Radical vaginal trachelectomy combined with laparoscopic lymphadenectomy is a safe method for treatment of patients with early-stage cervical cancer who are seeking parenthood.
authors.affiliation: Department of Gynecology, Charité University Medicine, Berlin, Germany. malgorzata.lanowska@charite.de
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Lanowska
authors.forename: Mandy
authors.initials: M
authors.lastname: Mangler
authors.forename: Annabel
authors.initials: A
authors.lastname: Spek
authors.forename: Ulrike
authors.initials: U
authors.lastname: Grittner
authors.forename: Kati
authors.initials: K
authors.lastname: Hasenbein
authors.forename: Vito
authors.initials: V
authors.lastname: Chiantera
authors.forename: Hermann
authors.initials: H
authors.lastname: Hertel
authors.forename: Achim
authors.initials: A
authors.lastname: Schneider
authors.forename: Christhardt
authors.initials: C
authors.lastname: Köhler
authors.forename: Dorothee
authors.initials: D
authors.lastname: Speiser
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D010535:Laparoscopy; D008197:Lymph Node Excision; D008875:Middle Aged; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D014621:Vagina / Q000601:surgery; D055815:Young Adult