title: Targeting nuclear bile acid receptors for liver disease.
abstract: Bile acids (BAs) are able to activate a range of dedicated nuclear receptors (NRs) which play a key role in the transcriptional control of critical steps of a wide range of hepatic functions ranging from BA homeostasis and bile formation, phase I/II metabolism of endo- and xenobiotics such as BAs and drugs, respectively, to hepatic lipids and glucose metabolism. Apart from these metabolic roles, BA-activated nuclear receptors also play a key role in the control of hepatic inflammation, fibrogenesis, replication of hepatitis B and C virus, liver regeneration and carcinogenesis. As such, several physiological and pathophysiological effects of BAs can now be explained through activation of regulatory NR networks. Moreover, BA-activated NRs are key for understanding the pathogenesis of several liver diseases and represent attractive drug targets. This article will provide a brief overview on the role of BA-activated NRs in cholestatic and fatty liver disease.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. michael.trauner@meduniwien.ac.at
authors.forename: Michael
authors.initials: M
authors.lastname: Trauner
authors.forename: Anna
authors.initials: A
authors.lastname: Baghdasaryan
authors.forename: Thierry
authors.initials: T
authors.lastname: Claudel
authors.forename: Peter
authors.initials: P
authors.lastname: Fickert
authors.forename: Emina
authors.initials: E
authors.lastname: Halilbasic
authors.forename: Tarek
authors.initials: T
authors.lastname: Moustafa
authors.forename: Gernot
authors.initials: G
authors.lastname: Zollner
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002779:Cholestasis / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D050356:Lipid Metabolism; D008107:Liver Diseases / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
chemical_list: D001647:Bile Acids and Salts; D018160:Receptors, Cytoplasmic and Nuclear