title: Contact transcleral photodynamic cyclo-suppression in human eyes: a feasibility study.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of contact transcleral ciliary body photodynamic treatment (CB-PDT) with verteporfin in human eyes.
  
  
  METHODS
  Prospective interventional case series.
  
  
  METHODS
  Five glaucomatous blind eyes of 5 patients.
  
  
  METHODS
  Verteporfin (6 mg/m(2)) was infused in bolus and then the ciliary body was irradiated transclerally with a fibre optic device. Twelve spots were placed 360° and 0.5 mm behind the sclerocorneal limbus. Laser power was 80 mW and irradiation time was 3 minutes.
  
  
  RESULTS
  The average intraocular pressure reduction was 30% after the first month and remained below pre-treatment levels throughout a 3-month follow-up. No serious adverse events were reported.
  
  
  CONCLUSIONS
  CB-PDT for refractory glaucoma was safe and efficient in human eyes; larger studies are required to evaluate its possible clinical role.
authors.affiliation: University Hospital of Heraklion, Department of Ophthalmology, Crete, Greece.
authors.forename: Spyridon K
authors.initials: SK
authors.lastname: Charisis
authors.forename: Efstathios T
authors.initials: ET
authors.lastname: Detorakis
authors.forename: Vania S
authors.initials: VS
authors.lastname: Vitanova
authors.forename: Vassilios A
authors.initials: VA
authors.lastname: Panteleontidis
authors.forename: Georgios A
authors.initials: GA
authors.lastname: Kounis
authors.forename: Miltiadis K
authors.initials: MK
authors.lastname: Tsilimbaris
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002924:Ciliary Body / Q000187:drug effects*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D015355:Glaucoma, Neovascular / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure; D053685:Laser Therapy; D007834:Lasers; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D011446:Prospective Studies; D012590:Sclera; D000077362:Verteporfin
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin