title: The role of anti-HLA antibodies in hematopoietic stem cell transplantation.
abstract: Donor-specific antihuman leukocyte antigen antibodies (DSHA) have been clearly implicated in graft rejection in solid organ transplantation. Their role in allogeneic hematopoietic stem-cell transplantation (allo-HSCT) remains unclear. We summarize here evidence supporting a role for DSHA in graft failure in animal models of allo-HSCT and in clinical settings whenever no full HLA matching occurs.
authors.affiliation: Division of Immunohematology, Azienda Ospedaliero-Univeritaria Pisana, via Paradisa 2, Pisa, Italy. dfocosi@tin.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Focosi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Zucca
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Scatena
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D004195:Disease Models, Animal; D006084:Graft Rejection / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans
chemical_list: D001323:Autoantibodies; D006680:HLA Antigens