title: [Efficacy of short-term metformin application in complex treatment of patients with coronary artery disease and concomitant metabolic syndrome].
abstract: The inclusion of a short course of metformin in complex therapy of coronary artery disease with metabolic syndrome does not alter the clinical features of disease. It had a positive effect on weight loss and the activity of systemic inflammation. The lipid metabolism and insulin resistance were not significantly altered. This results suggest that the treatment with metformin during 1 month in patients with coronary artery disease and metabolic syndrome is sufficient for the manifestation of systemic anti-inflammatory effect of the drug, but not enough to implement a reliable effect of insulin resistance and to improve the clinical features of coronary artery disease.
authors.forename: A V
authors.initials: AV
authors.lastname: Lavrenko
authors.forename: M S
authors.initials: MS
authors.lastname: Rasin
authors.forename: L A
authors.initials: LA
authors.lastname: Kutsenko
authors.forename: M V
authors.initials: MV
authors.lastname: Mikitiuk
authors.forename: I L
authors.initials: IL
authors.lastname: Solokhina
authors.forename: T V
authors.initials: TV
authors.lastname: Mamontova
authors.forename: I P
authors.initials: IP
authors.lastname: Kaĭdashev
mesh_terms: D000368:Aged; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D050260:Carbohydrate Metabolism / Q000187:drug effects; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D016207:Cytokines / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D007004:Hypoglycemic Agents; D008687:Metformin