title: Comparative antimicrobial activity of two new mutacins.
abstract: OBJECTIVE
  To compare the in vitro activity of mutacins D-123.1 and F-59.1 against different bacteria including antibiotic-resistant strains, in order to evaluate their application potential.
  
  
  METHODS
  The antibacterial activity spectrum of purified F-59.1 and the MIC and MBC of F-59.1 and D-123.1 against target bacteria were determined.
  
  
  RESULTS
  Most bacteria were inhibited by the purified mutacins. Mutacin F-59.1 shows a relatively wide activity spectrum. Mutacin D-123.1 has low Minimum Inhibitory Concentrations [MICs] (0.25-4 microg/ml) against human pathogens while F-59.1 has higher MICs (3.2-12.8 microg/ml) mainly against food-borne pathogens.
  
  
  CONCLUSIONS
  The effectiveness of mutacins D-123.1 and F-59.1 against human and food-borne pathogens is demonstrated. Mutacin D-123.1 shows potential as a new antibiotic while F-59.1 shows promising application in food products.
authors.affiliation: Département de Biochimie, Microbiologie et Bio-informatique, Faculté des Sciences et Génie, Université Laval, Québec, Canada. guillaume.nicolas.1@ulaval.ca
authors.forename: G G
authors.initials: GG
authors.lastname: Nicolas
authors.forename: G
authors.initials: G
authors.lastname: LaPointe
authors.forename: M C
authors.initials: MC
authors.lastname: Lavoie
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001430:Bacteriocins / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008826:Microbial Sensitivity Tests; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013295:Streptococcus mutans / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins