title: Recognition of thymine in DNA bulges by a Zn(II) macrocyclic complex.
abstract: A Zn(II) macrocyclic complex with appended quinoline is a bifunctional recognition agent that uses both the Zn(II) center and the pendent aromatic group to bind to thymine in bulges with good selectivity over DNA containing G, C or A bulges. Spectroscopic studies show that the stem containing the bulge stays largely intact in a DNA hairpin with the Zn(II) complex bound to the thymine bulge.
authors.affiliation: Department of Chemistry, University at Buffalo, State University of New York, Buffalo, NY, USA.
authors.forename: Imee Marie A
authors.initials: IM
authors.lastname: del Mundo
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Fountain
authors.forename: Janet R
authors.initials: JR
authors.lastname: Morrow
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry; D013941:Thymine / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D047028:Macrocyclic Compounds; D009841:Oligonucleotides; D011804:Quinolines; D004247:DNA; C037219:quinoline; D015032:Zinc; D013941:Thymine