title: Insulin sensitivity in late gestation and early postpartum period: the role of circulating maternal adipokines.
abstract: OBJECTIVE
  Early postpartum period is characterised by a dramatic decrease in insulin resistance and significant metabolic alterations. The aims of this study were to determine the changes in circulating maternal concentrations of total adiponectin, adiponectin multimers, leptin and resistin before and after the delivery and to explore their relationship with insulin sensitivity.
  
  
  METHODS
  Twenty-seven normal pregnant women at term were included in this longitudinal study. Blood samples were taken before and 4 days after elective caesarean section. Total adiponectin, adiponectin multimers, leptin, resistin, glucose, insulin and prolactin were measured in maternal serum. Adiponectin multimers were measured before and after the delivery in eight women.
  
  
  RESULTS
  (1) The mean maternal serum total adiponectin concentration was significantly higher before than after delivery while the relative distribution of circulating maternal adiponectin multimers did not change after delivery; (2) the median maternal serum concentration of leptin was significantly higher in the antepartum than in the postpartum period; (3) the median maternal serum resistin concentration was comparable before and after delivery; (4) multiple linear regression analysis revealed that antepartum insulin sensitivity was associated with maternal low body mass index, and low glucose concentrations in glucose challenge test, as well as with maternal age and increased leptin concentrations. Postpartum insulin sensitivity was associated with decreased circulating resistin concentrations.
  
  
  CONCLUSIONS
  Despite increase in insulin sensitivity, early postpartum period is characterised by a decrease in maternal circulating total adiponectin and by steady concentrations of resistin and adiponectin multimers compared to the late third trimester.
authors.affiliation: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Shali
authors.initials: S
authors.lastname: Mazaki-Tovi
authors.forename: Hannah
authors.initials: H
authors.lastname: Kanety
authors.forename: Clara
authors.initials: C
authors.lastname: Pariente
authors.forename: Rina
authors.initials: R
authors.lastname: Hemi
authors.forename: Eleanor
authors.initials: E
authors.lastname: Yissachar
authors.forename: Eyal
authors.initials: E
authors.lastname: Schiff
authors.forename: Ohad
authors.initials: O
authors.lastname: Cohen
authors.forename: Eyal
authors.initials: E
authors.lastname: Sivan
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008137:Longitudinal Studies; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011263:Pregnancy Trimester, Third / Q000097:blood*; D011388:Prolactin / Q000097:blood
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D007328:Insulin; D011388:Prolactin