title: [Potential of hematopoietic stem cells as the basis for generation of advanced therapy medicinal products].
abstract: Individualized, (stem) cell-based therapies of congenital and acquired illnesses are among the most exciting medical challenges of the twenty-first century. Before the full potential of such therapies can be achieved, many basic scientific and biotechnological questions remain to be answered. What is the ideal source for the generation of such cellular drugs is one of those issues. In many respects, hematopoietic stem cells fulfill the requirements for stem cells as starting material for novel cellular therapeutics, including the simple access to large amounts of stem cells, the availability of good phenotypic markers for their prospective isolation, and an extensive body of knowledge about the in vitro manipulation of these cells. This manuscript discusses the general and specific usability of hematopoietic stem cells as starting material for novel cellular therapeutics and presents some examples of hematological and nonhematological therapeutic approaches which are based on hematopoietic stem cells.
authors.affiliation: Institut für Transfusionsmedizin und Immunhämatologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main und DRK-Blutspendedienst Baden-Württemberg - Hessen gemeinnützige GmbH, Frankfurt, Sandhofstr. 1, 60528, Frankfurt, Deutschland. h.boenig@blutspende.de
authors.forename: H
authors.initials: H
authors.lastname: Bönig
authors.forename: M
authors.initials: M
authors.lastname: Heiden
authors.forename: J
authors.initials: J
authors.lastname: Schüttrumpf
authors.forename: M M
authors.initials: MM
authors.lastname: Müller
authors.forename: E
authors.initials: E
authors.lastname: Seifried
mesh_terms: D001709:Biotechnology / Q000379:methods*; D017690:Cell Transplantation / Q000379:methods*; D005544:Forecasting; D015316:Genetic Therapy / Q000379:methods*; D005858:Germany; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D057285:Precision Medicine; D044968:Regenerative Medicine / Q000379:methods; D035703:Therapies, Investigational / Q000379:methods*