title: [Determination of the content of zotarolimus on the drug eluting stents by HPLC].
abstract: OBJECTIVE
  To establish a method for the content determination of zotarolimus on the drug eluting stents.
  
  
  METHODS
  HPLC analysis was carried out with Zorbax Eclipse C8 column (4.6 x 75 mm 3.5 microm)and MPA acetate buffer solution: acetonitrile (51:49), MPB acetate buffer solution: acetonitrile (5:95) as the mobile phase. The detection wavelength was 278 nm.
  
  
  RESULTS
  There was a good linear relationship between the concentration of zotarolimus and the areas in the range of 5 microg/ml-75 microg/ml (r = 0.99986). The average recovery was 101.58% with RSD 0.68% (n = 6).
  
  
  CONCLUSIONS
  The method is simple, accurate and reproducible. It can be used as the quality test for zotarolimus on the drug eluting stents.
authors.affiliation: Tianjin Supervision and Testing Center for Medical Devices, 300191.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Xi
authors.initials: X
authors.lastname: Jiang
authors.forename: Bo
authors.initials: B
authors.lastname: Fan
authors.forename: Hong
authors.initials: H
authors.lastname: Cui
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D054855:Drug-Eluting Stents; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000032:analysis
chemical_list: C489443:zotarolimus; D020123:Sirolimus