title: [Effect of ethanol on nerve dependent vasorelaxation and vasoconstriction].
abstract: Vascular tone is controlled by endothelium and nerves innervating blood vessels. Endothelium releases various substances such as PGI2 (Prostacyclin), NO (nitric oxide), TXA2 (thromboxane A2) and ET-1 (endothelin-1). It is well documented that ethanol affects vascular responses mediated by these substances. On the other hand, peripheral vascular tone is also regulated not only by sympathetic adrenergic nerves but also by nonadrenergic noncholinergic (NANC) nerves. NANC nerves include NO nerves and sensory nerves which release calcitonin gene-related peptide (CGRP) and nerve-mediated hyperpolarizing factor (NDHF). However, effect of ethanol on nerve-mediated vascular responses remains poorly understood. Therefore, this review summarizes the effect of ethanol on the sympathetic adrenergic nerve-mediated vasoconstriction and the sensory nerve-mediated vasorelaxation.
authors.affiliation: Department of Legal Medicine, Nara Medical University, 840 Shijocho, Kashiharashi, Nara 634-8521, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Kudo
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Hatake
mesh_terms: D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects; D014666:Vasomotor System / Q000187:drug effects* / Q000502:physiology
chemical_list: D000431:Ethanol