title: Microwave-assisted synthesis of dinucleoside analogues containing a thiazolidin-4-one linkage via one-pot tandem Staudinger/aza-Wittig/cyclization.
abstract: Dinucleosides containing a thiazolidin-4-one linkage were prepared by one-pot tandem Staudinger/aza-Wittig/intermolecular cyclization under microwave irradiation and their structures were confirmed. Preliminary examination of HIV-RT inhibition showed that the dinucleosides containing (R)-thiazolidin-4-one linkage are significantly more active than those containing (S)-thiazolidin-4-one linkage.
authors.affiliation: Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei, China.
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Shen
authors.forename: Xiaoliu
authors.initials: X
authors.lastname: Li
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Yin
authors.forename: Zhanbin
authors.initials: Z
authors.lastname: Qin
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.forename: Jinchao
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhaipu
authors.initials: Z
authors.lastname: Ma
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015658:HIV Infections / Q000188:drug therapy; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015497:HIV-1 / Q000201:enzymology*; D008872:Microwaves; D008958:Models, Molecular; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D053778:Thiazolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D009705:Nucleosides; D053778:Thiazolidines; D054303:HIV Reverse Transcriptase