title: A composite renal tumor: metanephric adenofibroma, Wilms tumor, and renal cell carcinoma: a missing link?
abstract: A coexistence of different renal tumors has rarely been reported. The most commonly described association is of Wilms tumor and renal cell carcinoma. Metanephric adenofibroma has also been associated with Wilms tumor or papillary renal cell carcinoma. Another reported association is metanephric adenoma and papillary renal cell carcinoma with sarcomatoid dedifferentiation. Herein we describe a complex renal tumor containing areas of metanephric adenofibroma, Wilms tumor, and undifferentiated renal cell carcinoma in a previously healthy 18-year-old boy. The tumor showed histologic and immunohistochemical features of these 3 different tumors, offering additional support to the view that these 3 tumors are related.
authors.affiliation: Department of Pathology, Hospital Nacional de Pediatría JP Garrahan, Buenos Aires, Argentina.
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Galluzzo
authors.forename: Maria T
authors.initials: MT
authors.lastname: Garcia de Davila
authors.forename: Gordan M
authors.initials: GM
authors.lastname: Vujanić
mesh_terms: D000232:Adenofibroma / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D000293:Adolescent; D014408:Biomarkers, Tumor / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D008297:Male; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary / Q000628:therapy; D009392:Nephrectomy; D009396:Wilms Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor