title: Quantitative assessment of bone defect healing by multidetector CT in a pig model.
abstract: OBJECTIVE
  To evaluate multidetector CT volumetry in the assessment of bone defect healing in comparison to histopathological findings in an animal model.
  
  
  METHODS
  In 16 mini-pigs, a circumscribed tibial bone defect was created. Multidetector CT (MDCT) of the tibia was performed on a 64-row scanner 42 days after the operation. The extent of bone healing was estimated quantitatively by MDCT volumetry using a commercially available software programme (syngo Volume, Siemens, Germany).The volume of the entire defect (including all pixels from -100 to 3,000 HU), the nonconsolidated areas (-100 to 500 HU), and areas of osseous consolidation (500 to 3,000 HU) were assessed and the extent of consolidation was calculated. Histomorphometry served as the reference standard.
  
  
  RESULTS
  The extent of osseous consolidation in MDCT volumetry ranged from 19 to 92% (mean 65.4 ± 18.5%). There was a significant correlation between histologically visible newly formed bone and the extent of osseous consolidation on MDCT volumetry (r = 0.82, P < 0.0001). A significant negative correlation was detected between osseous consolidation on MDCT and histological areas of persisting defect (r = -0.9, P < 0.0001).
  
  
  CONCLUSIONS
  MDCT volumetry is a promising tool for noninvasive monitoring of bone healing, showing excellent correlation with histomorphometry.
authors.affiliation: Medical Faculty, Department of Diagnostic and Interventional Radiology, University Duesseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Riegger
authors.forename: Patric
authors.initials: P
authors.lastname: Kröpil
authors.forename: Pascal
authors.initials: P
authors.lastname: Jungbluth
authors.forename: Rotem S
authors.initials: RS
authors.lastname: Lanzman
authors.forename: Falk R
authors.initials: FR
authors.lastname: Miese
authors.forename: Ahmad R
authors.initials: AR
authors.lastname: Hakimi
authors.forename: Mohssen
authors.initials: M
authors.lastname: Hakimi
authors.forename: Michael
authors.initials: M
authors.lastname: Wild
authors.forename: Gerald
authors.initials: G
authors.lastname: Antoch
authors.forename: Axel
authors.initials: A
authors.lastname: Scherer
mesh_terms: D000818:Animals; D054893:Cone-Beam Computed Tomography / Q000379:methods; D005260:Female; D008297:Male; D061330:Multidetector Computed Tomography / Q000379:methods*; D010012:Osteogenesis / Q000502:physiology*; D013552:Swine; D013977:Tibia / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D013978:Tibial Fractures / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D014945:Wound Healing / Q000502:physiology*