title: Selective interaction of amyloid precursor protein with different isoforms of neural cell adhesion molecule.
abstract: Compare to the thoroughly studied beta-amyloid, the physiological function of amyloid precursor protein (APP) is not well understood. We now had identified neural cell adhesion molecule (NCAM)-140 as a potential interaction partner of APP. Our data indicated that NCAM-140, but not NCAM-180, binds to the conserved central extracellular domain of APP. We also found that the phosphorylation levels of ERK1 and ERK2 were increased when cells were co-transfected with NCAM-140 and APP indicate that the interaction between NCAM-140 and APP may involve the MAPK pathway. These findings demonstrated that NCAM-140 interacts with APP, potentially playing a role in neurite outgrowth and neural development.
authors.affiliation: Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing, 210009, China.
authors.forename: Ke-Ping
authors.initials: KP
authors.lastname: Chen
authors.forename: Fei
authors.initials: F
authors.lastname: Dou
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D019002:CD56 Antigen / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016466:CHO Cells; D019556:COS Cells; D002448:Cell Adhesion / Q000235:genetics; D002522:Chlorocebus aethiops; D006224:Cricetinae; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000235:genetics
chemical_list: C545487:APP protein, human; D016564:Amyloid beta-Protein Precursor; D019002:CD56 Antigen; C522918:NCAM1 protein, human; D020033:Protein Isoforms