title: The public health impact of coccidioidomycosis in Arizona and California.
abstract: The numbers of reported cases of coccidioidomycosis in Arizona and California have risen dramatically over the past decade, with a 97.8% and 91.1% increase in incidence rates from 2001 to 2006 in the two states, respectively. Of those cases with reported race/ethnicity information, Black/African Americans in Arizona and Hispanics and African/Americans in California experienced a disproportionately higher frequency of disease compared to other racial/ethnic groups. Lack of early diagnosis continues to be a problem, particularly in suspect community-acquired pneumonia, underscoring the need for more rapid and sensitive tests. Similarly, the inability of currently available therapeutics to reduce the duration and morbidity of this disease underscores the need for improved therapeutics and a preventive vaccine.
authors.affiliation: Global Health Sciences, University of California, San Francisco,1200 Beale St, #1200, San Francisco, CA 94105, USA. rhector@psg.ucsf.edu
authors.forename: Richard F
authors.initials: RF
authors.lastname: Hector
authors.forename: George W
authors.initials: GW
authors.lastname: Rutherford
authors.forename: Clarisse A
authors.initials: CA
authors.lastname: Tsang
authors.forename: Laura M
authors.initials: LM
authors.lastname: Erhart
authors.forename: Orion
authors.initials: O
authors.lastname: McCotter
authors.forename: Shoana M
authors.initials: SM
authors.lastname: Anderson
authors.forename: Kenneth
authors.initials: K
authors.lastname: Komatsu
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Tabnak
authors.forename: Duc J
authors.initials: DJ
authors.lastname: Vugia
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: John N
authors.initials: JN
authors.lastname: Galgiani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001130:Arizona / Q000453:epidemiology; D002140:California / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003045:Coccidioides / Q000276:immunology; D003047:Coccidioidomycosis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D005657:Fungal Vaccines; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000382:microbiology; D055815:Young Adult
chemical_list: D005657:Fungal Vaccines