title: Conjugated polymer nanoparticles for small interfering RNA delivery.
abstract: Loosely aggregated conjugated polymer nanoparticles (CPNs) were used as nontoxic and efficient small interfering RNA (siRNA) delivery vehicles with delivery visualization. A significant down regulation (94%) of a target gene was achieved by transfection of HeLa cells with the CPNs/siRNA complexes, supporting CPN as a promising siRNA delivery carrier.
authors.affiliation: Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th St., Miami, FL 33199, USA. jmoon@fiu.edu
authors.forename: Joong Ho
authors.initials: JH
authors.lastname: Moon
authors.forename: Eladio
authors.initials: E
authors.lastname: Mendez
authors.forename: Yong
authors.initials: Y
authors.lastname: Kim
authors.forename: Aman
authors.initials: A
authors.lastname: Kaur
mesh_terms: D000199:Actins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism*
chemical_list: D000199:Actins; D011108:Polymers; D034741:RNA, Small Interfering