title: Changes occur in resting state network of motor system during 4 weeks of motor skill learning.
abstract: We tested whether the resting state functional connectivity of the motor system changed during 4 weeks of motor skill learning using functional magnetic resonance imaging (fMRI). Ten healthy volunteers learned to produce a sequential finger movement by daily practice of the task over a 4 week period. Changes in the resting state motor network were examined before training (Week 0), two weeks after the onset of training (Week 2), and immediately at the end of the training (Week 4). The resting state motor system was analyzed using group independent component analysis (ICA). Statistical Parametric Mapping (SPM) second-level analysis was conducted on independent z-maps generated by the group ICA. Three regions, namely right postcentral gyrus, and bilateral supramarginal gyri were found to be sensitive to the training duration. Specifically, the strength of resting state functional connectivity in the right postcentral gyrus and right supramarginal gyrus increased from Week 0 to Week 2, during which the behavioral performance improved significantly, and decreased from Week 2 to Week 4, during which there was no more significant improvement in behavioral performance. The strength of resting state functional connectivity in left supramarginal gyrus increased throughout the training. These results confirm changes in the resting state network during slow-learning stage of motor skill learning, and support the premise that the resting state networks play a role in improving performance.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, TX 77054, USA. liangsuo.ma@uth.tmc.edu
authors.forename: Liangsuo
authors.initials: L
authors.lastname: Ma
authors.forename: Shalini
authors.initials: S
authors.lastname: Narayana
authors.forename: Donald A
authors.initials: DA
authors.lastname: Robin
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.forename: Jinhu
authors.initials: J
authors.lastname: Xiong
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001931:Brain Mapping; D016000:Cluster Analysis; D004525:Efferent Pathways / Q000502:physiology*; D005163:Factor Analysis, Statistical; D005260:Female; D005385:Fingers / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007858:Learning / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D009048:Motor Skills / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D025341:Principal Component Analysis; D012146:Rest / Q000502:physiology*; D012691:Serial Learning; D012984:Software; D055815:Young Adult