title: Comparison of nitrofen uptake via water and food and its distribution in tissue of common carp, Cyprinus carpio L.
abstract: Carp (Cyprinus carpio L.) were exposed to nitrofen (NIP) by different routes (via water or food) to compare bioaccumulation parameters and tissue distribution. The bioconcentration factor of NIP was 5,100, and the lipid-corrected biomagnification factor was 0.137. Growth-corrected elimination half lives were 2.1-3.0 days via aqueous exposure and 2.7-2.9 days via dietary exposure. From either uptake route, the tissue distribution of NIP was highest in the head, followed by muscle, viscera, dermis, digestive tract and hepatopancreas, which was highly correlated with the tissue lipid content. We conclude that the uptake route has no influence on tissue distribution of NIP and that the accumulation potential in tissues depends on the lipid content.
authors.affiliation: Chemicals Evaluation and Research Institute, Japan. inoue-yoshiyuki@ceri.jp
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Inoue
authors.forename: Naoki
authors.initials: N
authors.lastname: Hashizume
authors.forename: Erina
authors.initials: E
authors.lastname: Kikushima
authors.forename: Masanori
authors.initials: M
authors.lastname: Otsuka
mesh_terms: D000818:Animals; D002347:Carps / Q000254:growth & development / Q000378:metabolism*; D020405:Dermis / Q000187:drug effects / Q000378:metabolism; D004032:Diet / Q000662:veterinary*; D004784:Environmental Monitoring; D041981:Gastrointestinal Tract / Q000187:drug effects; D043143:Hepatopancreas / Q000187:drug effects / Q000378:metabolism; D006540:Herbicides / Q000493:pharmacokinetics / Q000633:toxicity*; D007564:Japan; D008055:Lipids / Q000737:chemistry; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D010647:Phenyl Ethers / Q000493:pharmacokinetics / Q000633:toxicity*; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects; D014781:Viscera / Q000187:drug effects / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D006540:Herbicides; D008055:Lipids; D010647:Phenyl Ethers; D014874:Water Pollutants, Chemical; C007350:nitrofen