title: Evidence of a pharmacodynamic EEG profile in rats following clonidine administration using a nonlinear analysis.
abstract: BACKGROUND
  Changes caused by clonidine in rodent electroencephalograms (EEG) have been reported with some inconsistency. For this reason, a pre-clinical study was conducted in order to confirm previous findings with both a standard spectral analysis and a sleep stage scoring procedure. In addition, a nonlinear technique for analysing the time-varying signals was implemented to compare its performance against conventional approaches.
  
  
  RESULTS
  The nonlinear method succeeds in quantifying all dose-related responses from the data set relying solely on the EEG trace.
  
  
  CONCLUSIONS
  Nonlinear approaches can deliver a suitable alternative to the sleep-stage scoring methods commonly used for drug effect detection.
authors.affiliation: Pfizer Global Research and Development, Ramsgate Road, Sandwich, CT13 9NJ, UK. david-olivier.azulay@wanadoo.fr.
authors.forename: David-Olivier D
authors.initials: DO
authors.lastname: Azulay
authors.forename: Benjamin
authors.initials: B
authors.lastname: Renoux
authors.forename: Magnus
authors.initials: M
authors.lastname: Ivarsson