title: Copper-catalyzed aerobic oxidative intramolecular alkene C-H amination leading to N-heterocycles.
abstract: A copper-catalyzed aerobic oxidative intramolecular alkene C-H amination has been developed using readily available substituted 3-benzylidene-2-pyridin-2-ylmethyl-2,3-dihydro-isoindol-1-ones as the starting materials, and the corresponding N-heterocycles were obtained in good to excellent yields. This method should provide a new and useful strategy for constructing N-heterocycles.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors.forename: Juyou
authors.initials: J
authors.lastname: Lu
authors.forename: Yibao
authors.initials: Y
authors.lastname: Jin
authors.forename: Hongxia
authors.initials: H
authors.lastname: Liu
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000475:Alkenes; D006576:Heterocyclic Compounds, 4 or More Rings; D003300:Copper