title: Left-sided Pseudomonas aeruginosa endocarditis in patients without injection drug use.
abstract: We aimed to determine the clinical features, predisposing factors, and outcome of left-sided Pseudomonas aeruginosa endocarditis in persons with no history of injection drug use. We performed a retrospective review of patient medical records from Mayo Clinic (Rochester, MN; Scottsdale, AZ; and Jacksonville, FL) for all cases of left-sided P. aeruginosa endocarditis. We identified 4 cases. We present these cases, as well as a review of the English-language medical literature. Data gathered included the year the case was reported; the valve involved; treatment, including valve replacement surgery; and outcome, if known. Left-sided P. aeruginosa endocarditis in persons without injection drug use is a rare but serious infection, with a history of instrumentation as a common predisposing condition. Valvular surgery is indicated, when possible, for the best chance of survival, along with extended therapy with combination antibiotics for complete recovery.
authors.affiliation: From Division of Hospital Internal Medicine (NLD) and the Division of Infectious Diseases (LMB, SA), Mayo Clinic, Jacksonville, Florida; the Division of Clinical Microbiology (BSP, JDY), Mayo Clinic, Rochester, Minnesota; and the Division of Consultative Medicine (JDE) Mayo Clinic, Scottsdale, Arizona.
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Dawson
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Brumble
authors.forename: Bobbi S
authors.initials: BS
authors.lastname: Pritt
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Yao
authors.forename: J Dan
authors.initials: JD
authors.lastname: Echols
authors.forename: Salvador
authors.initials: S
authors.lastname: Alvarez
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures / Q000379:methods; D016208:Databases, Factual; D018450:Disease Progression; D017548:Echocardiography, Transesophageal / Q000379:methods; D004697:Endocarditis, Bacterial / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D015819:Substance Abuse, Intravenous; D015996:Survival Rate
chemical_list: D000900:Anti-Bacterial Agents