title: Cascading adoptive cell therapy for metastatic melanoma.
abstract: Adoptive tumor-infiltrating lymphocytes (TILs) therapy has demonstrated drastic effects on advanced malignant melanoma. Intensive pretreatment such as chemotherapy and/or total body irradiation has been used to eliminate immunosuppressive components and therefore enhances the antitumor effects of TILs. However, these pretreatments may cause severe side effects, especially for elderly patients. This case observes the complete response of how a patient with metastatic melanoma was treated sequentially with local tumor resection, postoperative adoptive cytokine-induced killer cells and TILs infusion. In addition, the cascading adoptive cell therapy was well-tolerated by the patient. Therefore, being pretreated with cytokine-induced killer cells could ameliorate the immunosuppressive condition in the patient and provide a favorable circumstance for subsequent TILs infusion. The further adoptive TILs therapy could exert the most powerful antitumor activity in such an amicable circumstance.
authors.affiliation: Biomedical Research Center, The First Hospital of Kunming, Kunming, People's Republic of China. suxs163@163.com
authors.forename: Xiaosan
authors.initials: X
authors.lastname: Su
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Shangmin
authors.initials: S
authors.lastname: Wu
authors.forename: Liangkun
authors.initials: L
authors.lastname: Jin
authors.forename: Junsong
authors.initials: J
authors.lastname: Ye
authors.forename: Zheng
authors.initials: Z
authors.lastname: Guan
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
mesh_terms: D000368:Aged; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D016207:Cytokines / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016219:Immunotherapy, Adoptive / Q000379:methods*; D016246:Lymphocytes, Tumor-Infiltrating / Q000166:cytology; D008545:Melanoma / Q000628:therapy*; D009362:Neoplasm Metastasis; D011379:Prognosis; D012074:Remission Induction; D012878:Skin Neoplasms / Q000628:therapy*; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D007166:Immunosuppressive Agents