title: Arrhythmia triggers in heart failure: the smoking gun of [Ca2+]i dysregulation.
abstract: Among the most serious problems associated with heart failure is the increased likelihood of life-threatening arrhythmias. Both triggered and reentrant arrhythmias in heart failure may arise as a result of aberrant intracellular Ca cycling. This article presents some new ideas, based on recent studies, about how altered Ca cycling in heart failure might serve as the cellular basis for arrhythmogenesis.
authors.affiliation: Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
authors.forename: Gary L
authors.initials: GL
authors.lastname: Aistrup
authors.forename: C William
authors.initials: CW
authors.lastname: Balke
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Wasserstrom
mesh_terms: D000200:Action Potentials; D001145:Arrhythmias, Cardiac / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006333:Heart Failure / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D032383:Myocytes, Cardiac / Q000378:metabolism*
chemical_list: D002118:Calcium