title: 2010 report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders.
abstract: These data indicate increasing use of HCT for persons with blood and bone marrow disorders. Recent trends include increasing use of alternative donors including HLA-matched unrelated persons and of HLA-matched umbilical cord blood cells, increasing use of blood cell rather than bone marrow grafts and increasing use of reduced-intensity pretransplant conditioning regimens. Many of these shifts are driven by logistical considerations like the need for donors in persons without an HLA-identical sibling or expanding access to allotransplants to older patients. In other instances, like the shift from bone marrow to blood cell grafts or from conventional to reduced-intensity pretransplant conditioning regimens few randomized clinical trials have been reported to justify these shifts. More data are needed to critically-assess the impact of these changes.
authors.affiliation: Center for Blood and Marrow Transplant Research (CIBMTR), and the Medical College of Wisconsin Clinical Cancer Center, Milwaukee, Wisconsin, USA.
authors.forename: Marcelo C
authors.initials: MC
authors.lastname: Pasquini
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Wang
authors.forename: Mary M
authors.initials: MM
authors.lastname: Horowitz
authors.forename: Robert Peter
authors.initials: RP
authors.lastname: Gale
mesh_terms: D000047:Academies and Institutes; D001855:Bone Marrow Diseases / Q000601:surgery*; D003299:Cooperative Behavior; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006085:Graft Survival; D006402:Hematologic Diseases / Q000601:surgery*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D007391:International Cooperation; D010043:Outcome and Process Assessment, Health Care / Q000706:statistics & numerical data; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome