title: Measurement of mucosal conductivity by MII is a potential marker of mucosal integrity restored in infants on acid-suppression therapy.
abstract: Esophageal multichannel intraluminal impedance (MII) allows measurement of the conductivity of adjacent contents. During esophageal rest, raw impedance levels may represent mucosal integrity. We assessed the influence of proton pump inhibitors (PPIs) on presumed mucosal integrity by reanalyzing raw MII levels of 21 pH-MII tracings from infants with gastroesophageal reflux (GER) disease before and after esomeprazole treatment. Median (interquartile range) esophageal MII increased during treatment, 938 (652-1304) versus 1885 (1360-2183) Ohm, P < 0.0001. Patients with lower MII levels demonstrated a larger increase on therapy: Spearman r2 = 0.28, P = 0.014. No correlation with standard GER parameters was observed. In conclusion, PPI therapy increases MII levels in infants with symptomatic GER disease.
authors.affiliation: Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands. c.m.loots@amc.nl
authors.forename: Clara M
authors.initials: CM
authors.lastname: Loots
authors.forename: Michiel P
authors.initials: MP
authors.lastname: Van Wijk
authors.forename: Marije J
authors.initials: MJ
authors.lastname: Smits
authors.forename: Tobias G
authors.initials: TG
authors.lastname: Wenzl
authors.forename: Marc A
authors.initials: MA
authors.lastname: Benninga
authors.forename: Taher I
authors.initials: TI
authors.lastname: Omari
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D015415:Biomarkers; D015331:Cohort Studies; D004553:Electric Conductivity; D055664:Electrochemical Techniques; D064098:Esomeprazole / Q000627:therapeutic use; D004947:Esophagus / Q000187:drug effects* / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D009092:Mucous Membrane / Q000187:drug effects* / Q000503:physiopathology; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D000897:Anti-Ulcer Agents; D015415:Biomarkers; D054328:Proton Pump Inhibitors; D064098:Esomeprazole