title: HLA-B27 association with uveitis in an Asian Indian population.
abstract: BACKGROUND
  Uveitis refers to diseases characterized by intraocular inflammation of the uveal tract. Anterior uveitis is a common ocular disease characterized by inflammation of the iris and the ciliary body.
  
  
  OBJECTIVE
  To establish the frequency of HLA-B27-positive uveitis in Asian Indian population, study their clinical profile and compare it with other reports in literature.
  
  
  METHODS
  We retrospectively reviewed medical data of 89 patients of uveitis referred for HLA B27 typing with predominantly ocular symptoms during the period from April 2006-October 2010. All patients were tested for complete blood count, erythrocyte sedimentation rate, infectious diseases serology, HLA-B27 typing, and prepared radiographs of the sacroiliac joints and lumbar spine if required.
  
  
  RESULTS
  The HLA-B27 positive rate was 56.2% among patients and 3% for control samples. Most of the patients were in the age group of 41-50 years with a male predominance.
  
  
  CONCLUSIONS
  HLA-B27 was seen to be associated with acute anterior uveitis in Asian Indian males and the test is important for confirmation of diagnosis, prognostication and also for planning the treatment.
authors.affiliation: Dr. Lal Pathology Reference Laboratory, Rohini, New Delhi, India. mnmishra@hotmail.com
authors.forename: Mahendra Narin
authors.initials: MN
authors.lastname: Mishra
authors.forename: Khurshed Minoo
authors.initials: KM
authors.lastname: Bharucha
mesh_terms: D000328:Adult; D044466:Asian People; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007194:India / Q000453:epidemiology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011859:Radiography; D012189:Retrospective Studies; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics* / Q000503:physiopathology
chemical_list: D015796:HLA-B27 Antigen