title: Structural features and bioactivities of the chitosan.
abstract: Fourier transform infrared (FT-IR) spectroscopic studies (3500-600 cm(-1)) showed some different bands of chitosan. The absorption at 3439 cm(-1) is stretching vibration of -OH and -NH(2) bonds, indicating the association of the hydrogen-bond between them. The bands at 1659, 1599 and 1321 cm(-1) are attributable to the peaks of stretching vibrations of amide I (ν((C=O))), II (δ((N-H))), and the peak of stretching and bending vibrations of III (ν((C-N))) (δ((N-H))). The chitosan showed strong free radical scavenging activities. Pretreatment with chitosan significantly prevented the decrease of antioxidant enzymes activities and the increase of p-JNK at 3 h after renal ischemia and reduced renal tubular epithelial cell apoptosis.
authors.affiliation: Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Mi
authors.forename: Xiaohou
authors.initials: X
authors.lastname: Wu
authors.forename: ChunLi
authors.initials: C
authors.lastname: Luo
authors.forename: JiaBing
authors.initials: J
authors.lastname: Li
authors.forename: YaXiong
authors.initials: Y
authors.lastname: Tang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D013481:Superoxides; D009569:Nitric Oxide; D048271:Chitosan; D048031:JNK Mitogen-Activated Protein Kinases