title: Association of rs6983561 polymorphism at 8q24 with prostate cancer mortality in a Japanese population.
abstract: We conducted present study to address whether the rs6983561 polymorphism, an established genetic marker for prostate cancer susceptibility, was a prognostic indicator. We genotyped 518 Japanese patients with prostate cancer and analysed their survival retrospectively. As a result, patients with the CA/CC genotype of rs6983561 survived significantly longer than those with the AA genotype (P = .033).
  
  
  BACKGROUND
  Genome-wide association studies have revealed several genetic variants at 8q24 that are associated with prostate cancer susceptibility. Rs6983561 (A/C) is a single-nucleotide polymorphism located at 8q24 that has been established as a genetic risk marker for prostate cancer susceptibility. The present study investigated the association between the rs6983561 polymorphism and prostate cancer mortality in a Japanese population.
  
  
  METHODS
  The study examined 518 native Japanese male patients with sporadic prostate cancer. Germline DNA samples were obtained from all participants and genotyping of rs6983561 was performed using a TaqMan assay. Observation periods were from the date of diagnosis of prostate cancer to May 21, 2010. The Cox proportional hazards model was used to estimate the cause-specific survival (CSS) and the overall survival (OS).
  
  
  RESULTS
  Patients with the CA/CC genotype of rs6983561 survived significantly longer than those with the AA genotype. In a multivariate model, the hazard ratios (HRs) and 95% confidence intervals (CIs) of the CSS and the OS for the rs6983561 polymorphism were 2.438 (1.262 - 5.046, P = .007) and 1.957 (1.142 - 3.485, P = .014), respectively. When the analysis was restricted to subjects with metastatic disease, the HRs of the CSS and the OS were 3.353 (95% CI, 1.689 - 7.446; P = 3.76 x 10(-4)) and 3.361 (95% CI, 1.741 - 7.136; P = 1.70 x 10(-4)), respectively.
  
  
  CONCLUSIONS
  In the Japanese population examined in this study, the rs6983561 polymorphism at 8q24 was significantly associated with prostate cancer mortality, especially among patients with metastatic disease.
authors.affiliation: Department of Urology, Graduate School of Medicine, The University of Tokyo, Japan. SUZUKIMURO@h.u-tokyo.ac.jp
authors.forename: Motofumi
authors.initials: M
authors.lastname: Suzuki
authors.forename: Miao
authors.initials: M
authors.lastname: Liu
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kurosaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Suzuki
authors.forename: Tomio
authors.initials: T
authors.lastname: Arai
authors.forename: Motoji
authors.initials: M
authors.lastname: Sawabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kasuya
authors.forename: Moriaki
authors.initials: M
authors.lastname: Kato
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Fujimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukuhara
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Enomoto
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nishimatsu
authors.forename: Akira
authors.initials: A
authors.lastname: Ishikawa
authors.forename: Haruki
authors.initials: H
authors.lastname: Kume
authors.forename: Yukio
authors.initials: Y
authors.lastname: Homma
authors.forename: Tadaichi
authors.initials: T
authors.lastname: Kitamura
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007564:Japan; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000628:therapy