title: MicroRNAs as a novel cellular senescence regulator.
abstract: Cellular senescence is a program activated in normal cells in response to various types of stresses and is manifested by permanent arrest of cell cycle. Cellular senescence is closely related to tumor suppression, and may contribute to the ageing of organisms. The complex senescence cell phenotype has many different mechanisms. Recent studies have provided important insights regarding the role played by miRNAs during cellular senescence as a novel molecular mechanism. In this article, we will review the latest advances in the identification and validation of senescence-regulatory miRNAs and the possible mechanisms.
authors.affiliation: Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
authors.forename: Feng-Jiao
authors.initials: FJ
authors.lastname: Liu
authors.forename: Tie
authors.initials: T
authors.lastname: Wen
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
mesh_terms: D000375:Aging / Q000235:genetics* / Q000502:physiology; D000818:Animals; D016922:Cellular Senescence / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D018816:Genes, cdc / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs