title: Drug-induced glucose-6-phosphate dehydrogenase deficiency-related hemolysis risk assessment.
abstract: Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme that protects human red blood cells from premature destruction caused by oxidative damage. People suffering from G6PD deficiency would be vulnerable to various oxidative substances, such as fava beans and oxidant drugs. Until now, many institutes, organizations or domain experts have compiled low-risk or high-risk drugs collection for patients with G6PD deficiency, mainly from the case report or clinical trails. Recently, we have explored a classification system to predict drug-induced hemolytic potential. In this paper, we screen the normally used over-the-counter (OTC) drugs for "high-risk" and "low-risk" ones to G6PD deficient patients by this system.
authors.affiliation: School of Life Science and Technology, Tongji University, 1239 SiPing Road, Shanghai 200092, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Zuofeng
authors.initials: Z
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Nan
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D016208:Databases, Factual; D064420:Drug-Related Side Effects and Adverse Reactions; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood / Q000150:complications*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D018570:Risk Assessment; D018511:Systems Integration
chemical_list: D004364:Pharmaceutical Preparations