title: Fluxgate magnetorelaxometry for characterization of hydrogel polymerization kinetics and physical entrapment capacity.
abstract: Hydrogels have the potential for providing drug delivery systems with long release rates. The polymerization kinetics and the physical entrapment capacity of photo-cross-linked hydroxyethyl methacrylate hydroxyethylstarch hydrogels are investigated with a non-destructive method. For this purpose, superparamagnetic nanoparticles as replacements for biomolecules are used as probes. By analyzing their magnetic relaxation behavior, the amounts of physically entrapped and mobile nanoparticles can be determined. The hydrogels were loaded with five different concentrations of nanoparticles. Different methods of analysis of the relaxation curves and the influence of the microviscosity are discussed. This investigation allows one to optimize the UV light irradiation time and to determine the amount of physically entrapped nanoparticles in the hydrogel network. It was found that the polymerization kinetics is faster for decreasing nanoparticle concentration but not all nanoparticles can be physically entrapped in the network.
authors.affiliation: Institut für Elektrische Messtechnik und Grundlagen der Elektrotechnik, TU Braunschweig, Hans-Sommer-Straße 66, 38106 Braunschweig, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Heim
authors.forename: S
authors.initials: S
authors.lastname: Harling
authors.forename: F
authors.initials: F
authors.lastname: Ludwig
authors.forename: H
authors.initials: H
authors.lastname: Menzel
authors.forename: M
authors.initials: M
authors.lastname: Schilling