title: Functionalized lipid nanoparticles-cellophane hybrid films for molecular delivery: preparation, physicochemical characterization, and stability.
abstract: Lipid nanoparticles functionalized with the sunscreen 2,4-dihydroxybenzophenone (FLNPs) have been prepared by the ultrasound method and embedded in highly hydrophilic cellophane supports (regenerated cellulose, RC), creating biocompatible hybrid films (RC-FLNPs samples). The morphology of the FLNPs was studied with transmission microscopy, whereas the surface and interior chemical composition was analyzed by micro-Raman spectroscopy. RC-FLNPs hybrid films were prepared from the immersion of two cellophane supports with different thicknesses and water uptake properties (RC-3 and RC-6) in an aqueous dispersion of FLNPs. The structure of this hybrid material was visualized with bright-field microscopy, which clearly showed the inclusion of the FLNPs in the cellophane matrix. The stability of the RC-FLNPs films with respect to both aqueous environments and time was demonstrated by NaCl diffusion measurements. The reduction in the diffusion coefficient through the nanoparticle-modified films compared with the original supports confirms the presence of nanoparticles for concentration gradients of up to 0.4 M (osmotic pressure around 10 bar), indicating the stability of the hybrid hydrophilic material, even in aqueous environments and under matter flow conditions for a period of 21 days.
authors.affiliation: Dept. de Física Aplicada, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain.
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Vázquez
authors.forename: Laura
authors.initials: L
authors.lastname: Peláez
authors.forename: Juana
authors.initials: J
authors.lastname: Benavente
authors.forename: J Manuel
authors.initials: JM
authors.lastname: López-Romero
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Rico
authors.forename: Jesus
authors.initials: J
authors.lastname: Hierrezuelo
authors.forename: Elena
authors.initials: E
authors.lastname: Guillén
authors.forename: M Rosa
authors.initials: MR
authors.lastname: López-Ramírez
mesh_terms: D002476:Cellophane; D004355:Drug Stability; D008055:Lipids / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D013059:Spectrum Analysis, Raman
chemical_list: D008055:Lipids; D002476:Cellophane