title: [Quick finding of absorption ingredients of Paeoniae Radix Alba by SEMAC].
abstract: OBJECTIVE
  To establish a method for quick finding of the absorption ingredients of Paeoniae Radix Alba in order to select the index of quality control.
  
  
  METHODS
  The absorption ingredients of three concentration of Paeoniae Radix Alba were investigated with the in vitro-everted intestinal sac (VEIS) model. The intestinal sac fluids of jejunum and ileum were collected in different time and detected by HPLC. The accumulative absorption quantity of albiflorin and paeoniflorin were calculated, respectively.
  
  
  RESULTS
  Five ingredients could be detected. In different concentrations of Paeoniae Radix Alba, albiflorin and paeoniflorin in various intestinal sections were the linear absorption (R2 > 0.9), conformed to the zero order absorption rate. The values of Ka in the jejunum and ileum were increased along with the raised dosage of the Paeoniae Radix Alba (P < 0.05), indicating a passive absorption manner.
  
  
  CONCLUSIONS
  SEMAC could be used as a tool to find the absorption ingredients of Paeoniae Radix Alba. Compared with the jejunum, the ileum could provide the more absorption information. It was showed that the optimal detecting time was 60 min.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Tan
authors.forename: Weihao
authors.initials: W
authors.lastname: Wang
authors.forename: Bei
authors.initials: B
authors.lastname: Song
authors.forename: Liangmian
authors.initials: L
authors.lastname: Chen
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhu
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Wang
authors.forename: Jiucheng
authors.initials: J
authors.lastname: Cui
mesh_terms: D000818:Animals; D007408:Intestinal Absorption; D008297:Male; D029596:Paeonia; D051381:Rats; D017208:Rats, Wistar