title: Intestinal carcinogenesis: IKK can go all the way.
abstract: Chronic inflammation has long been suspected to support tumorigenesis in a variety of cancers. The IκB kinase (IKK)/NF-κB pathway is the critical signal transduction pathway regulating inflammation, and loss-of-function studies have demonstrated its involvement in tumorigenesis. In this issue of the JCI, Vlantis et al. present evidence that persistent genetic activation of IKK/NF-κB signaling in intestinal epithelial cells not only accelerates tumorigenesis in models of both carcinogen- and mutation-induced colorectal cancer, but also is sufficient to induce intestinal tumors.
authors.affiliation: Institute of Physiological Chemistry, University of Ulm, Ulm, Germany.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Sunami
authors.forename: Thomas
authors.initials: T
authors.lastname: Wirth
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000201:enzymology*; D051550:I-kappa B Kinase / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000166:cytology*; D007414:Intestinal Neoplasms / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D051550:I-kappa B Kinase