title: Cellular reprogramming of somatic cells.
abstract: The process of 'cell reprogramming' can be achieved by somatic cell nuclear transfer, cell fusion with embryonic stem cells, exposure to stem cell extracts, or by inducing pluripotentcy mediated by defined factors giving rise to what are termed induced pluripotent stem cells. More recently, the fate of a somatic cell can be directly induced to uptake other cell fates, termed lineage-specific reprogramming, without the need to de-differentiate the cells to a pluripotent state. In this review we will describe the different methods of reprogramming somatic cells.
authors.affiliation: Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton VIC 3168, Australia.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Sumer
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Verma
mesh_terms: D000818:Animals; D054337:Cell Dedifferentiation; D002459:Cell Fusion; D019070:Cell Lineage; D019976:Cloning, Organism; D044127:Epigenesis, Genetic; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D053652:Nuclear Transfer Techniques