title: Insulin-like growth factor binding protein-3, in association with IGF-1 receptor, can predict prognosis in squamous cell carcinoma of the head and neck.
abstract: The aim of this study was to investigate the prognostic role of insulin-like growth factor-1 receptor (IGF-1R) and IGF binding protein-3 (IGFBP-3) in patients with squamous cell carcinoma of the head and neck (SCCHN). The clinical data of 131 SCCHN patients who had undergone surgical resection were retrospectively reviewed, and their intratumoral expression of IGF-1R and IGFBP-3 was evaluated by immunohistochemistry. Thirty-six cases (27.5%) experienced tumor recurrence during the median follow-up period of 53.7months (95% CI, 19.0-90.7months). IGF-1R-positivity and IGFBP-3-positivity were observed in 96 (73.3%) and 70 cases (53.4%), respectively. IGFBP-3-positivity was associated with shorter time to progression (TTP) by univariate (P=0.03) and multivariate analyses (95% CI, 0.23-0.91), whereas IGF-1R itself failed to show its prognostic relevance. However, it was revealed that the prognostic role of IGFBP-3 expression was dependent on IGF-1R expression in the analysis of four subgroups classified according to IGF-1R and IGFBP-3 expression: the IGF-1R-positive/IGFBP-3-positive subgroup was the best prognostic group, while the IGF-1R-negative/IGFBP-3-positive subgroup was the worst in terms of TTP (P=0.017). In conclusion, it is suggested that IGFBP-3 expression, in a state of co-expression with IGF-1R, can predict poor prognosis in SCCHN patients.
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Jong-Mu
authors.initials: JM
authors.lastname: Sun
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Jun
authors.forename: Young Hyeh
authors.initials: YH
authors.lastname: Ko
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Park
authors.forename: Yong Chan
authors.initials: YC
authors.lastname: Ahn
authors.forename: Young-Ik
authors.initials: YI
authors.lastname: Son
authors.forename: Jeong-Hwan
authors.initials: JH
authors.lastname: Baek
authors.forename: Keunchil
authors.initials: K
authors.lastname: Park
authors.forename: Myung-Ju
authors.initials: MJ
authors.lastname: Ahn
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D018972:Insulin-Like Growth Factor Binding Protein 3; D017526:Receptor, IGF Type 1