title: Relationship between cardiovascular risk factors and adipokines in adolescents.
abstract: This study evaluated the associations of adipokines with cardiovascular risk factors.
  
  
  METHODS
  60 normal weight (BMI ≤75th percentile) and 60 overweight (BMI ≥95th percentile) adolescents aged 10-14 years. Resting systolic and diastolic blood pressures (SBP, DBP) and waist circumference were obtained in duplicate. Circulating adiponectin, resistin, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), total cholesterol (TC), high-density lipoprotein (HDL), and triglycerides (TG) were measured from fasting plasma samples.
  
  
  RESULTS
  Simple correlations showed that SBP was significantly related (p < 0.05) to adiponectin (r = -0.185), resistin (r = 0.207), and IL-6 (r = 0.238); HDL was significantly related to adiponectin (r = 0.398) and TNF-α (r = -0.227). TG was only related to adiponectin (r = -0.292, p < 0.05). Multiple regression models controlling for puberty and ethnicity indicated that adiponectin (R(2) = 0.152, p < 0.05), resistin (R(2) = 0.152, p < 0.05), and IL-6 (R(2) = 0.170, p < 0.05) were associated with SBP. The association between adiponectin and HDL was stronger in normal weight versus overweight adolescents (R(2) = 0.336, p < 0.05). None of the other models showed differences in the associations by weight status.
  
  
  CONCLUSIONS
  In adolescents, SBP but not DBP was associated with most adipokines. HDL, but not TC, was also associated with some adipokines. TG were only associated with adiponectin. Associations were mostly related to adiposity.
authors.affiliation: Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USA. drubin@fullerton.edu
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Rubin
authors.forename: Robert G
authors.initials: RG
authors.lastname: McMurray
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Hackney
authors.forename: Joanne S
authors.initials: JS
authors.lastname: Harrell
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D050177:Overweight; D012044:Regression Analysis; D052243:Resistin / Q000097:blood; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055105:Waist Circumference
chemical_list: D054392:Adipokines; D052242:Adiponectin; D008076:Cholesterol, HDL; D015850:Interleukin-6; D052243:Resistin; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol