title: Dyslipidemia in human kidney transplant recipients receiving cyclosporine and tacrolimus is associated with different expression of CD36 on peripheral blood monocytes.
abstract: OBJECTIVE
  We studied the mechanisms by which immunosuppressants result, in dyslipidemia among human kidney transplant recipients.
  
  
  METHODS
  Seventy-five living donor kidney transplant recipients were enrolled in our study with informed consent and the approval of out Institutional Ethics Committee. Each donor-recipient pair were relatives, there were no prisoners. The serum lipid profile, the expression of CD36 on peripheral blood monocytes, and the whole blood concentrations of cyclosporine (CsA) or tacrolimus (FK506) were determined at various times after transplantation.
  
  
  RESULTS
  CsA significantly increased serum lipid concentrations. The CsA concentration correlated positively with low-density lipoprotein cholesterol (LDL) levels, whereas FK506 showed no significant effect on serum lipid level. There was a positive correlation between the CsA concentrations and the expression of CD36; FK507 showed no significant effect on CD36 expression.
  
  
  CONCLUSIONS
  Hyperlipidemia in kidney transplant recipients treated with CsA was associated with overexpression of CD36 on peripheral blood monocytes.
authors.affiliation: Department of Urology, Shaoyang Central Hospital, 422000, Shaoyang, Peoples Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.forename: X B
authors.initials: XB
authors.lastname: Xie
authors.forename: L K
authors.initials: LK
authors.lastname: Peng
authors.forename: F H
authors.initials: FH
authors.lastname: Peng
authors.forename: G B
authors.initials: GB
authors.lastname: Lan
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: S J
authors.initials: SJ
authors.lastname: Yu
authors.forename: C H
authors.initials: CH
authors.lastname: Fang
mesh_terms: D000328:Adult; D018955:CD36 Antigens / Q000276:immunology*; D016572:Cyclosporine / Q000008:administration & dosage*; D050171:Dyslipidemias / Q000150:complications*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D016559:Tacrolimus / Q000008:administration & dosage*
chemical_list: D018955:CD36 Antigens; D016572:Cyclosporine; D016559:Tacrolimus