title: Association of the metabolic syndrome and long-term renal function in kidney donors.
abstract: BACKGROUND
  Metabolic syndrome (MetS) may represent risk factor for long-term renal function of kidneys from living donors. The aim of this study was to evaluate the impact of MetS on renal function in donors.
  
  
  METHODS
  Data regarding the presence or absence of MetS and renal function, as assessed by estimated glomerular filtration rate (eGFR) were obtained from 140 kidney donors before nephrectomy (BN) and at follow-up (AF). Donors were divided into those with (group 1; n =28) versus without MetS (group 2; n = 112).
  
  
  RESULTS
  Comparing the groups, we observed a significantly greater reduction in eGFR among the group with MetS BN versus AF 27.5% (19.3-33.0) versus 21.4% (9.6-34.1 P = .02) respectively using a Cox regression model, including age, gender, serum uric acid, body mass index (BMI), and basal eGFR, MetS BN (hazard ratio = 2.2; 95% confidence interval [CI], 1.21-4.01; p = .01) was an independent factor associated with a greater risk of a-eGFR <70 mL/min/1.73 m(2) at follow-up (P < .001). Additionally, age (hazard ratio = 1.03%; 95% CI, 1.01-1.06; P < .001), and female gender (hazard ratio = 1.86; 95% CI, 1.03-3.36; P = .03) were associated with a greater decrease in eGFR. Individuals with MetS BN showed a GFR <70 mL/min/1.73 m(2) at significantly shorter follow-up time (5.6 ± 0.8 years) versus persons without MetS (12.8 ± 1.0 years; P = .001)
  
  
  CONCLUSIONS
  Kidney donors with MetS BN experiment a significantly greater decrease in eGFR at follow-up.
authors.affiliation: Departmentsof Endocrinology and Metabolism, Instituto Nacional de ciencias médicas y Nutrició Salvador Zubirán Mexico City, Mexico.
authors.forename: D
authors.initials: D
authors.lastname: Cuevas-Ramos
authors.forename: P
authors.initials: P
authors.lastname: Almeda-Valdés
authors.forename: M
authors.initials: M
authors.lastname: Arvizu
authors.forename: J
authors.initials: J
authors.lastname: Mata
authors.forename: L E
authors.initials: LE
authors.lastname: Morales-Buenrostro
authors.forename: B
authors.initials: B
authors.lastname: Gabilondo
authors.forename: M
authors.initials: M
authors.lastname: Vilatobá
authors.forename: R
authors.initials: R
authors.lastname: Correa-Rotter
authors.forename: F
authors.initials: F
authors.lastname: Gabilondo-Navarro
authors.forename: R
authors.initials: R
authors.lastname: Mehta
authors.forename: C A
authors.initials: CA
authors.lastname: Aguilar-Salinas
authors.forename: J
authors.initials: J
authors.lastname: Alberú
authors.forename: F J
authors.initials: FJ
authors.lastname: Gómez-Pérez
mesh_terms: D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D016016:Proportional Hazards Models; D014019:Tissue Donors