title: Molecularly imprinted polymers for (90)Sr urine bioassay.
abstract: A molecularly imprinted polymer (MIP) comprising dicyclohexano-18-crown-6 (DCH18C6) was synthesized as a Sr-selective sorbent for urine bioassay purposes. MIP particles (326 ± 2 nm diameter) were formed using acetone and acetonitrile (1:3 v/v) as the porogen, methacrylic acid (MAA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the cross-linker. The DCH18C6-MIP particles were impregnated with additional DCH18C6 and treated further with NaOH to attain better binding affinity for Sr(2+). The effects of pH, ionic strength and amount of particles were evaluated for optimal extraction of (90)Sr(2+) from urine samples, as measured by liquid scintillation analysis (LSA). After up to 94% of (90)Y was removed by precipitation with TiO(2), DCH18C6-MIP particles were applied for selective SPE of (90)Sr remaining in the urine matrix for final LSA.
authors.affiliation: Department of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
authors.forename: Negar
authors.initials: N
authors.lastname: Bahraini
authors.forename: Edward P C
authors.initials: EP
authors.lastname: Lai
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Li
authors.forename: Baki B
authors.initials: BB
authors.lastname: Sadi
authors.forename: Gary H
authors.initials: GH
authors.lastname: Kramer
mesh_terms: D003432:Cross-Linking Reagents / Q000737:chemistry; D043844:Crown Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods*; D009994:Osmolar Concentration; D011834:Radiation Monitoring / Q000379:methods*; D012588:Scintillation Counting / Q000379:methods; D012680:Sensitivity and Specificity; D013325:Strontium Isotopes / Q000378:metabolism / Q000652:urine*
chemical_list: D003432:Cross-Linking Reagents; D043844:Crown Ethers; D008689:Methacrylates; D013325:Strontium Isotopes; C002570:dicyclohexyl-18-crown-6; C008384:methacrylic acid; C004919:ethylene dimethacrylate