title: [Examples of results of pharmaceutical cerebrovascular protection, with special emphasis on the statins].
abstract: Despite that hypercholesterinemia is not a risk factor of stroke, treatment with statins is able to reduce these events in a clinically relevant degree. Intervention trials suggest that while for primary prevention, statins are effective in conventional dose, after stroke or TIA this is true only if LDL-cholesterol is reduced below 1,8 mmol/L. To reach this goal, usually intensive antilipid treatment is necessary. There are studies showing beneficial impacts of other lipid drugs, beyond statins, i.e. fibrates and fish oil (among the settings of primary, and secondary preventions, respectively). Against cerebro-vascular events, pleiotropic effects of some antihypertensive and antidiabetic medications can also be established.
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ, I. sz. Belgyógyászati Klinika, Hetényi Géza Endokrinológiai és Anyagcsere Osztály, Anyagcsere Szakprofil, Pécs. laszlo.bajnok@aok.pte.hu
authors.forename: László
authors.initials: L
authors.lastname: Bajnok
mesh_terms: D000959:Antihypertensive Agents / Q000494:pharmacology; D002545:Brain Ischemia / Q000209:etiology / Q000517:prevention & control*; D016893:Carotid Stenosis / Q000150:complications / Q000188:drug therapy; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000150:complications; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D058607:Fibric Acids / Q000494:pharmacology; D005395:Fish Oils / Q000494:pharmacology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology; D055502:Secondary Prevention; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000959:Antihypertensive Agents; D058607:Fibric Acids; D005395:Fish Oils; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents