title: Direct analysis of camptothecin from Nothapodytes nimmoniana by desorption electrospray ionization mass spectrometry (DESI-MS).
abstract: Desorption electrospray ionization was employed for fast and direct ambient detection of the anti-tumor drug, camptothecin, and its derivative, 9-methoxycamptothecin in Nothapodytes nimmoniana. Different parts of the plant such as leaves, stems and bark were examined. The ion intensities suggest that the concentration in bark is higher than that in the leaves and stems. The method does not require any sample preparation or preseparation. The identity of the alkaloids was further confirmed by tandem mass spectrometry.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600036, India.
authors.forename: Amitava
authors.initials: A
authors.lastname: Srimany
authors.forename: Demian R
authors.initials: DR
authors.lastname: Ifa
authors.forename: Hemanta R
authors.initials: HR
authors.lastname: Naik
authors.forename: Vasudeva
authors.initials: V
authors.lastname: Bhat
authors.forename: R Graham
authors.initials: RG
authors.lastname: Cooks
authors.forename: T
authors.initials: T
authors.lastname: Pradeep
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000032:analysis*; D019684:Magnoliopsida / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000191:economics / Q000379:methods
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C025724:9-methoxycamptothecin; D002166:Camptothecin