title: [Treatment and prevention of NSAIDs induced colonic mucosal lesions].
abstract: Individuals who regularly take NSAIDs have a significantly higher incidence of lower intestinal lesions when compared with non-NSAID takers. Based on this understanding, NSAID induced colonic mucosal lesions are found in about 3% of NSAID takers and this risk can increase further with the duration of NSAID ingestion. The essential step in the treatment of NSAIDs induced colonic lesions is discontinuation of NSAID ingestion, which is factored in the diagnostic criteria for NSAID induced colonic mucosal lesions. Accordingly, subjects who adhere to the recommended prognostic criteria achieve a rapid mucosal healing. However, there is lack of knowledge on medications which should be effective both in promoting healing of the lesions and also preventing a future relapse of NSAID induced colonic lesions. Based on this thinking, further studies and therapeutic trials are warranted to better treat not only gastro-duodenal ulcers but also lower intestinal lesions associated with NSAIDs.
authors.affiliation: Department of Gastroenterology, Juntendo University School of Medicine.
authors.forename: Taro
authors.initials: T
authors.lastname: Osada
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Shibuya
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003108:Colonic Diseases / Q000139:chemically induced* / Q000517:prevention & control; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal