title: Effect of environmental contaminants on Beta cell function.
abstract: There is an increasing concern that chemicals in the environment are contributing to the global rise in the prevalence of type 2 diabetes (T2D). However, there is limited evidence for direct effects of these chemicals on beta cell function. Therefore, the goals of this study were (1) to test the hypothesis that environmental contaminants can directly affect beta cell function and (2) examine mechanistic pathways by which these contaminants could affect beta cell function. Using mouse beta TC-6 cells, we examined the acute effects of 6 substances (benzo[a]pyrene, bisphenol A [BPA], propylparaben, methylparaben, perfluorooctanoic acid, and perfluorooctyl sulfone) on insulin secretion. Only BPA treatment directly affected insulin secretion. Furthermore, chronic exposure to BPA altered the expression of key proteins in the cellular and endoplasmic reticulum stress response. These data suggest that long-term BPA exposure may be detrimental to beta cell function and ultimately be an important contributor to the etiology of T2D.
authors.affiliation: Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Emilija
authors.initials: E
authors.lastname: Makaji
authors.forename: Sandeep
authors.initials: S
authors.lastname: Raha
authors.forename: Michael G
authors.initials: MG
authors.lastname: Wade
authors.forename: Alison C
authors.initials: AC
authors.lastname: Holloway
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D001564:Benzo(a)pyrene / Q000633:toxicity; D015415:Biomarkers; D002210:Caprylates / Q000633:toxicity; D002460:Cell Line; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced; D059865:Endoplasmic Reticulum Stress; D004785:Environmental Pollutants / Q000633:toxicity*; D005466:Fluorocarbons / Q000633:toxicity; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects*; D051379:Mice; D008928:Mitochondria / Q000187:drug effects; D010226:Parabens / Q000633:toxicity; D010636:Phenols / Q000633:toxicity; D015995:Prevalence; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D001564:Benzo(a)pyrene; D015415:Biomarkers; D002210:Caprylates; D004785:Environmental Pollutants; D005466:Fluorocarbons; D007328:Insulin; D010226:Parabens; D010636:Phenols; C023036:perfluorooctanoic acid; C015358:methylparaben; C006780:bisphenol A; D000098826:Bisphenol A Compounds; C006068:propylparaben