title: Low incidence rate of opportunistic and viral infections during imatinib treatment in chronic myeloid leukemia patients in early and late chronic phase.
abstract: BACKGROUND
  Imatinib has become first line therapy in chronic myeloid leukemia patients. Little is known about the infective consequences during the treatment with this drug in large series of chronic phase patients.
  
  
  METHODS
  From January 2001 to September 2006 we treated with imatinib 250 patients in first line (early CP) or after interferon failure (late CP), out of clinical trials and recorded all the bacterial and viral infections occurred.
  
  
  RESULTS
  We recorded a similar incidence of bacterial and viral infections both in first line and late CP patients (respectively, 16% and 13%) during 3.5 years of follow-up. Analysis of presenting features predisposing to infections revealed differences only in late CP patients, with elevated percentage of high Sokal risk patients and a more longer median time from diagnosis to start of imatinib.
  
  
  CONCLUSIONS
  Opportunistic infections and reactivation of Herpes Zoster are observed during imatinib therapy at very low incidence.
authors.affiliation: Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Breccia
authors.forename: Corrado
authors.initials: C
authors.lastname: Girmenia
authors.forename: Roberto
authors.initials: R
authors.lastname: Latagliata
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Loglisci
authors.forename: Michelina
authors.initials: M
authors.lastname: Santopietro
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Federico
authors.forename: Luigi
authors.initials: L
authors.lastname: Petrucci
authors.forename: Alessandra
authors.initials: A
authors.lastname: Serrao
authors.forename: Adriano
authors.initials: A
authors.lastname: Salaroli
authors.forename: Giuliana
authors.initials: G
authors.lastname: Alimena