title: What is new for an old molecule? Systematic review and recommendations on the use of resveratrol.
abstract: BACKGROUND
  Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark.
  
  
  METHODS
  Literature search in databases as PUBMED and ISI Web of Science in combination with manual search was used to answer the following five questions: (1)Can resveratrol be recommended in the prevention or treatment of human diseases?; (2)Are there observed "side effects" caused by the intake of resveratrol in humans?; (3)What is the relevant dose of resveratrol?; (4)What valid data are available regarding an effect in various species of experimental animals?; (5)Which relevant (overall) mechanisms of action of resveratrol have been documented?
  
  
  CONCLUSIONS
  The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.
authors.affiliation: Department of Science, System and Models, Roskilde University, Roskilde, Denmark. ov@ruc.dk
authors.forename: Ole
authors.initials: O
authors.lastname: Vang
authors.forename: Nihal
authors.initials: N
authors.lastname: Ahmad
authors.forename: Clifton A
authors.initials: CA
authors.lastname: Baile
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Baur
authors.forename: Karen
authors.initials: K
authors.lastname: Brown
authors.forename: Anna
authors.initials: A
authors.lastname: Csiszar
authors.forename: Dipak K
authors.initials: DK
authors.lastname: Das
authors.forename: Dominique
authors.initials: D
authors.lastname: Delmas
authors.forename: Carmem
authors.initials: C
authors.lastname: Gottfried
authors.forename: Hung-Yun
authors.initials: HY
authors.lastname: Lin
authors.forename: Qing-Yong
authors.initials: QY
authors.lastname: Ma
authors.forename: Partha
authors.initials: P
authors.lastname: Mukhopadhyay
authors.forename: Namasivayam
authors.initials: N
authors.lastname: Nalini
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: Tristan
authors.initials: T
authors.lastname: Richard
authors.forename: Yogeshwer
authors.initials: Y
authors.lastname: Shukla
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Surh
authors.forename: Thomas
authors.initials: T
authors.lastname: Szekeres
authors.forename: Tomasz
authors.initials: T
authors.lastname: Szkudelski
authors.forename: Thomas
authors.initials: T
authors.lastname: Walle
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Wu
mesh_terms: D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D013267:Stilbenes; D000077185:Resveratrol