title: Ghrelin biology and its role in weight-related disorders.
abstract: The discovery of ghrelin and its role in human metabolism has promoted significant research and advances in the study of obesity and other weight-related disorders. Ghrelin is relevant to many disorders of metabolism and weight such as obesity, cachexia, Prader-Willi Syndrome (PWS), and Anorexia Nervosa (AN), and its role in the pathophysiology differs. The changes observed in ghrelin physiology in these disorders shed light on the overall role of ghrelin in human metabolism and growth. The purpose of this review is to summarize the existing literature on ghrelin and some disorders of metabolism and growth. The disorders that will be discussed include obesity, cachexia, PWS, and AN. Within each disorder we will review relevant ghrelin physiology, recent studies, and potential modes of intervention with ghrelin analogues.
authors.affiliation: Division of Adolescent Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Ohio 45229, USA.
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: Hillman
authors.forename: Jenny
authors.initials: J
authors.lastname: Tong
authors.forename: Matthias
authors.initials: M
authors.lastname: Tschop
mesh_terms: D000818:Animals; D000856:Anorexia Nervosa / Q000235:genetics / Q000378:metabolism; D001835:Body Weight / Q000235:genetics / Q000502:physiology*; D002100:Cachexia / Q000235:genetics / Q000378:metabolism; D054439:Ghrelin / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D011218:Prader-Willi Syndrome / Q000235:genetics / Q000378:metabolism
chemical_list: D054439:Ghrelin