title: [Points that should be considered for selecting drugs for the prevention and treatment of NSAIDs-related ulcers].
abstract: Many factors including past-history of ulcers, co-administration of glucocorticoid, and age of a case are important for selecting anti-ulcer medications to prevent the occurrence of gastro-duodenal ulcers during the administration of non-steroidal anti-inflammatory drugs (NSAIDs). In Japan, lansoprazole is a first line therapeutic drug for high risk patients with a past-history of ulcers, since lansoprazole is approved by the Japanese regulating agency to be administered to chromic NSAIDs users with a history of gastro-duodenal ulcers for preventing the recurrence of ulcers. Other high risk patients without ulcer history may be treated by the preventive administration of misoprostol. When misoprostol can not be used because of side effects etc, rebamipide and histamine-H2-recepter antagonists like famotidine are considered to be good options. For the treatment of NSAIDs-related gastro-duodenal ulcers, proton pump inhibitors or prostaglandins are selected if NSAIDs administration can not be interrupted. For the prevention and treatment of NSAIDs-related intestinal ulcers, the information we have is not clear enough for the appropriate drug selection.
authors.affiliation: Department of Gastroenterology and Hepatology, Shimane University School of Medicine.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tamagawa
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D011453:Prostaglandins / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006635:Histamine H2 Antagonists; D011453:Prostaglandins; D054328:Proton Pump Inhibitors