title: Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: setting, degradation and drug release considerations.
abstract: This study has investigated novel bone adhesives consisting of fluid photo-polymerizable poly(lactide-co-propylene glycol-co-lactide)dimethacrylate (PGLA-DMA) mixed with systematically varying fillers of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate (MCPM), for the delivery of an antibacterial drug chlorhexidine (CHX). All formulations were found to polymerize fully within 200 s after exposure to blue light. In addition, water sorption by the polymerized materials catalyzed varying filler conversion to dicalcium phosphate (DCP) (i.e. brushite and monetite). With greater DCP levels, faster degradation was observed. Moreover, increase in total filler content enhanced CHX release, associated with higher antibacterial activity. These findings thus suggest that such rapid-setting and degradable adhesives with controllable drug delivery property could have potential clinical value as bone adhesives with antibacterial activity.
authors.affiliation: Biomaterials and Tissue Engineering Research Department, UCL Eastman Dental Institute, London, UK.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Irwin
authors.initials: I
authors.lastname: Olsen
authors.forename: Jonathan
authors.initials: J
authors.lastname: Pratten
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Knowles
authors.forename: Anne M
authors.initials: AM
authors.lastname: Young
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D001843:Bone Cements; D002130:Calcium Phosphates / Q000737:chemistry*; D002710:Chlorhexidine / Q000493:pharmacokinetics; D004952:Esters; D004987:Ethers; D005163:Factor Analysis, Statistical; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D002130:Calcium Phosphates; D004952:Esters; D004987:Ethers; D008689:Methacrylates; D014867:Water; C020243:calcium phosphate; D002710:Chlorhexidine