title: Idiopathic pulmonary hypertension causing acquired von Willebrand disease and menorrhagia.
abstract: BACKGROUND
  Von Willebrand disease (VWD) maybe inherited or acquired; both etiologies can be associated with heavy menstrual bleeding. Pulmonary arterial hypertension may result in acquired VWD due to the destruction of high molecular weight von Willebrand multimers. We report a case of menorrhagia due to acquired VWD in a patient with idiopathic pulmonary hypertension.
  
  
  METHODS
  An adolescent female with known idiopathic pulmonary hypertension developed acquired VWD. Her primary disease necessitates the use of platelet inhibitors and intermittent anticoagulation. At menarche she also developed menorrhagia due to acquired VWD. She is currently controlled with stimate and progesterone-only therapy. VWD in a patient with idiopathic pulmonary hypertension causing menorrhagia. Although VWD and menorrhagia are commonly linked, the treatment and disease process in a patient with idiopathic pulmonary arterial hypertension is incredibly complex.
authors.affiliation: Department of Pediatric and Adolescent Gynecology, Baylor College of Medicine, Houston, TX, USA. sokkary@bcm.tmc.edu
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Sokkary
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Dietrich
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Venkateswaran
mesh_terms: D002648:Child; D004844:Epistaxis / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000188:drug therapy; D008595:Menorrhagia / Q000188:drug therapy / Q000209:etiology*; D014842:von Willebrand Diseases / Q000188:drug therapy / Q000209:etiology*