title: Antihyperglycaemic effects of ethanol extracts of Carica papaya and Pandanus amaryfollius leaf in streptozotocin-induced diabetic mice.
abstract: Diabetes mellitus is a global disease that is increasing in an alarming rate. The present study was undertaken to study the antidiabetic effect of the ethanol extracts of Carica papaya and Pandanus amaryfollius on streptozotocin-induced diabetic mice. The results of the present study indicated that there was no significant difference in the body weight of the treated groups when compared to diabetic control. Whereas, there was significant (P < 0.05) decrease in the blood glucose level of the plant-treated groups compared to the diabetic control. Histologically the pancreas of the treated groups indicated significant regeneration of the β-cells when compared to the diabetic control. The liver tissues of the treated group indicated a reduction in fatty changes and pyknotic nucleus. The kidney tissues of the treated groups indicated significant recovery in the cuboidal tissue. The results from the phytochemical screening indicated the presence of flavonoids, alkaloids, saponin and tannin in C. papaya and P. amaryfollius. The antidiabetic effect of C. papaya and P. amaryfollius observed in the present study may be due to the presence of these phytochemicals.
authors.affiliation: Institute for Research in Molecular Medicine (INFORMM), University Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia. srisasidharan@yahoo.com
authors.forename: Sreenivasan
authors.initials: S
authors.lastname: Sasidharan
authors.forename: Vello
authors.initials: V
authors.lastname: Sumathi
authors.forename: Naidu Rameshwar
authors.initials: NR
authors.lastname: Jegathambigai
authors.forename: Lachimanan Yoga
authors.initials: LY
authors.lastname: Latha
mesh_terms: D000470:Alkaloids / Q000032:analysis; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D029441:Carica / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D000431:Ethanol; D005419:Flavonoids / Q000032:analysis; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D050417:Insulin-Secreting Cells / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D051379:Mice; D016688:Mice, Inbred NOD; D031673:Pandanaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry*; D012503:Saponins / Q000032:analysis; D013634:Tannins / Q000032:analysis
chemical_list: D000470:Alkaloids; D001786:Blood Glucose; D005419:Flavonoids; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D012503:Saponins; D013634:Tannins; D000431:Ethanol