title: Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases.
abstract: BACKGROUND
  Scientists have been trying to understand the molecular mechanisms of diseases to design preventive and therapeutic strategies for a long time. For some diseases, it has become evident that it is not enough to obtain a catalogue of the disease-related genes but to uncover how disruptions of molecular networks in the cell give rise to disease phenotypes. Moreover, with the unprecedented wealth of information available, even obtaining such catalogue is extremely difficult.
  
  
  RESULTS
  We developed a comprehensive gene-disease association database by integrating associations from several sources that cover different biomedical aspects of diseases. In particular, we focus on the current knowledge of human genetic diseases including mendelian, complex and environmental diseases. To assess the concept of modularity of human diseases, we performed a systematic study of the emergent properties of human gene-disease networks by means of network topology and functional annotation analysis. The results indicate a highly shared genetic origin of human diseases and show that for most diseases, including mendelian, complex and environmental diseases, functional modules exist. Moreover, a core set of biological pathways is found to be associated with most human diseases. We obtained similar results when studying clusters of diseases, suggesting that related diseases might arise due to dysfunction of common biological processes in the cell.
  
  
  CONCLUSIONS
  For the first time, we include mendelian, complex and environmental diseases in an integrated gene-disease association database and show that the concept of modularity applies for all of them. We furthermore provide a functional analysis of disease-related modules providing important new biological insights, which might not be discovered when considering each of the gene-disease association repositories independently. Hence, we present a suitable framework for the study of how genetic and environmental factors, such as drugs, contribute to diseases.
  
  
  BACKGROUND
  The gene-disease networks used in this study and part of the analysis are available at http://ibi.imim.es/DisGeNET/DisGeNETweb.html#Download.
authors.affiliation: Research Programme on Biomedical Informatics (GRIB), IMIM (Hospital del Mar Research Institute), Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Bauer-Mehren
authors.forename: Markus
authors.initials: M
authors.lastname: Bundschus
authors.forename: Michael
authors.initials: M
authors.lastname: Rautschka
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Mayer
authors.forename: Ferran
authors.initials: F
authors.lastname: Sanz
authors.forename: Laura I
authors.initials: LI
authors.lastname: Furlong
mesh_terms: D016000:Cluster Analysis; D004194:Disease / Q000235:genetics*; D004777:Environment; D053263:Gene Regulatory Networks / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D005810:Multigene Family / Q000235:genetics; D010641:Phenotype