title: Relationship between diarrhea and peripheral leukocyte population in neonatal Japanese black calves.
abstract: Neonatal Japanese Black (JB) calves show a high incidence of diarrhea. The objective of this study was to analyze the immune cell populations of neonatal JB calves in detail and examine its correlation with the incidence of diarrhea immediately after birth. Understanding the immune cell populations is helpful in clinics in order to determine the condition of the immune system for prevention of diseases. Blood samples were obtained from JB calves on the day of birth. The peripheral leukocyte populations were analyzed separately for calves that had diarrhea within 2 weeks after birth (diarrhea group; n = 26) and for calves without diarrhea (control group; n = 74). The numbers of the peripheral blood CD3(+)TcR1-N12(+) and CD8(+) T cells were significantly lower in the diarrhea group compared with the control group. These findings suggest that the congenital lower peripheral γδ and CD8(+) T cells results in a high risk of diarrhea in neonatal JB calves.
authors.affiliation: School of Veterinary Medicine, Kitasato University, Towada, Aomori 034–8628, Japan. otsuka@vmas.kitasato-u.ac.jp
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Ohtsuka
authors.forename: Machiko
authors.initials: M
authors.lastname: Mukai
authors.forename: Erika
authors.initials: E
authors.lastname: Tanami
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tokita
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Hashiba
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kohiruimaki
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Shibano
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Miura
authors.forename: Stephen
authors.initials: S
authors.lastname: Morris
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000276:immunology*; D003967:Diarrhea / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D005260:Female; D007958:Leukocyte Count / Q000662:veterinary; D018655:Lymphocyte Count / Q000662:veterinary; D008297:Male; D013601:T-Lymphocytes / Q000378:metabolism*