title: Postoperative serum concentrations of high mobility group box chromosomal protein-1 correlates to the duration of SIRS and pulmonary dysfunction following gastrointestinal surgery.
abstract: OBJECTIVE
  To clarify the time course of changes in the serum HMGB-1 concentrations in patients undergoing major gastrointestinal surgery, and to investigate whether the serum HMGB-1 levels correlate with the postoperative clinical course of the patients.
  
  
  METHODS
  Twenty-eight patients with alimentary tract carcinoma who underwent elective gastrointestinal surgery were enrolled in this study. The correlation between the serum HMGB-1 levels and the postoperative clinical course were evaluated.
  
  
  RESULTS
  Serum HMGB-1 concentrations in patients who underwent surgery for gastrointestinal cancer increased gradually during postoperative days, and reached peak concentrations on postoperative day 3 (POD3). There was a statistically significant positive correlation between the serum HMGB-1 levels on POD3 or POD5 and the duration of SIRS (r = 0.68, P < 0.001, r = 0.45, P < 0.05, respectively). A significantly positive correlation was found between the serum HMGB-1 levels on POD3 or POD5 and the heart rates on POD3 or POD5. Furthermore, there was a negative correlation between the serum HMGB-1 levels and PaO2/FiO2 ratio on POD3.
  
  
  CONCLUSIONS
  Serum HMGB-1 levels increase after major gastrointestinal surgery, and the serum peak HMGB-1 levels correlate with the duration of SIRS and postoperative pulmonary dysfunction.
authors.affiliation: Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Takahata
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ono
authors.forename: Hironori
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hiraki
authors.forename: Akifumi
authors.initials: A
authors.lastname: Kimura
authors.forename: Manabu
authors.initials: M
authors.lastname: Kinoshita
authors.forename: Hiromi
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Daizoh
authors.initials: D
authors.lastname: Saitoh
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hase
mesh_terms: D000368:Aged; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000097:blood / Q000601:surgery*; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D008171:Lung Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011183:Postoperative Complications / Q000097:blood*; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood*; D013997:Time Factors
chemical_list: D024243:HMGB1 Protein; D010100:Oxygen