title: Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea.
abstract: Two new diterpenoid quinonemethides (1 and 2) along with two known compounds (3 and 4) were isolated from the hexane and ethyl acetate extracts of root nodules of Pygmacopremna herbacea. The structures of the new compounds were established by spectroscopic data interpretation. Single crystal X-ray diffraction analysis confirmed the structure of 1. The cytotoxic activities of these compounds were evaluated against A 549, HEPG2, MCF-7, PC-3 and HELA cancer cell lines. Compounds 4, 2 and 1 were shown very good cytotoxic activity.
authors.affiliation: Organic Chemistry Division-II, Indian Institute of Chemical Technology, Hyderabad, India.
authors.forename: K
authors.initials: K
authors.lastname: Satish
authors.forename: M V P S
authors.initials: MV
authors.lastname: Vishnuvardhan
authors.forename: V Lakshma
authors.initials: VL
authors.lastname: Nayak
authors.forename: G
authors.initials: G
authors.lastname: Srihari
authors.forename: M
authors.initials: M
authors.lastname: Subrahamanyam
authors.forename: T Prabhakar
authors.initials: TP
authors.lastname: Rao
authors.forename: S
authors.initials: S
authors.lastname: Ramakrishna
authors.forename: K
authors.initials: K
authors.lastname: Ravikumar
authors.forename: B
authors.initials: B
authors.lastname: Sridhar
authors.forename: M Marthanda
authors.initials: MM
authors.lastname: Murthy
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D045563:Indolequinones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D029648:Verbenaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045563:Indolequinones; C068040:quinone methide