title: Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models.
abstract: BACKGROUND
  Peptic ulcer is a global health problem of the gastrointestinal tract characterized by mucosal damage secondary to pepsin and gastric acid secretion which occurs due to due to an imbalance between offensive and defensive factors.
  
  
  OBJECTIVE
  The present study was carried out with methanolic extract of the seed coat of Tamarindus indica Linn. to evaluate its antiulcer potential on ibuprofen, alcohol and pyloric ligation induced gastric lesions.
  
  
  METHODS
  Doses of 100 mg/kg & 200 mg/kg of methanolic extract wre administered orally to rats of different groups. Ranitidine at a dose of 50 mg/kg was used as a standard drug for these gastric ulcer models. The gastric content was collected and the volume was measured. The ulceration index was determined by examining the inner lining of each stomach. Furthermore, the effect was assessed by free acidity, pepsin activity, total carbohydrate (TC), protein content (PK).
  
  
  RESULTS
  The result showed that the methanolic extract of seed coats of Tamarindus indica significantly reduce the total volume of gastric juice, free and total acidity of gastric secretion (P < 0.01) in pylorus ligation induced ulcer model as is comparable with the standard drug ranitidine. There was also a significant reduction in ulcer index (P < 0.01) as compared to control group.
  
  
  CONCLUSIONS
  The methanolic extracts of seed coat of Tamarindus indica can be used as a new source of antiulcer agent in animals.
authors.affiliation: Rayat and Bahra Institute of Pharmacy, Mohali, Chandigarh.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Kalra
authors.forename: Sunil
authors.initials: S
authors.lastname: Sharma
authors.lastname: Suman
authors.forename: Suresh
authors.initials: S
authors.lastname: Kumar