title: Weight-based loading of vancomycin in patients on hemodialysis.
abstract: We evaluated weight-based loading doses of vancomycin and resulting initial prehemodialysis concentrations. Modeling demonstrated modest correlation between dose administered, age, and initial concentration achieved. Actual body weight-based loading of vancomycin predictably achieves therapeutic initial concentrations in patients who receive hemodialysis.
authors.affiliation: Department of Pharmacy, Hahnemann University Hospital, Philadelphia, Pennsylvania, USA.
authors.forename: Merideth
authors.initials: M
authors.lastname: Brown
authors.forename: Radhika
authors.initials: R
authors.lastname: Polisetty
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Gracely
authors.forename: Bulent
authors.initials: B
authors.lastname: Cuhaci
authors.forename: Hans P
authors.initials: HP
authors.lastname: Schlecht
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001835:Body Weight; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D010949:Plasma / Q000737:chemistry; D006435:Renal Dialysis / Q000009:adverse effects*; D014640:Vancomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin