title: Successful management of metastatic urothelial carcinoma with gemcitabine and Paclitaxel chemotherapy in a hemodialysis patient.
abstract: This is the first report of urothelial carcinoma (UC) in a hemodialysis (HD) patient treated with almost the same doses of gemcitabine and paclitaxel (GP) as those administered to patients with normal renal function. There have been some reports of UC treated with cisplatin-based chemotherapy in HD patients. However, there have only been a few reports of UC treated with GP in HD patients. Furthermore, to our knowledge, there has not been any report of UC in a HD patient treated with almost the same doses of GP as those in patients with normal renal function. Following cystectomy for bladder cancer, a 73-year-old woman undergoing HD developed lung metastasis and received combination chemotherapy with almost the same doses of GP as those in patients with normal renal function. After three cycles were completed, metastatic tumors disappeared and there has not been any recurrence or metastasis for 1 year to date. Furthermore, there were no grade 3 or 4 adverse effects during this treatment.
authors.affiliation: Department of Urology, Saitama Municipal Hospital, Saitama, Japan. h-ide @ fc4.so-net.ne.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ide
authors.forename: Atsuko
authors.initials: A
authors.lastname: Satou
authors.forename: Katsura
authors.initials: K
authors.lastname: Hoshino
authors.forename: Yota
authors.initials: Y
authors.lastname: Yasumizu
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Uchida
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tasaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Masuda
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D019540:Area Under Curve; D002277:Carcinoma / Q000150:complications / Q000188:drug therapy*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D009362:Neoplasm Metastasis; D017239:Paclitaxel / Q000008:administration & dosage*; D006435:Renal Dialysis / Q000379:methods*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000188:drug therapy*; D019459:Urothelium / Q000473:pathology*; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D017239:Paclitaxel; D000093542:Gemcitabine