title: Tissue microarray analysis of RANKL in cutaneous lupus erythematosus and psoriasis.
abstract: Recently, it was discovered that the receptor activator of nuclear factor κB (RANK)/RANK ligand (RANKL) is part of an important signal transduction pathway for tissue homoeostasis. Therefore, we were interested in investigating RANKL expression in the epidermis of skin lesions from patients with different subtypes of cutaneous lupus erythematosus (CLE) and psoriasis as well as normal healthy donors. Using the tissue microarray technique, skin biopsy specimens were evaluated by immunohistochemistry. RANKL showed a significantly increased expression in the epidermis of skin biopsy specimens from patients with psoriasis (median: 4, range: 0-5) compared to patients with CLE (median: 0, range: 0-4) (P<0.001). No significant differences in epidermal RANKL expression between the CLE subtypes were detected. These data show a different expression of RANKL in the epidermis of skin lesions from patients with CLE compared to those with psoriasis suggesting that RANKL might play an important role in the pathogenesis of the disease.
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Toberer
authors.forename: Jaromir
authors.initials: J
authors.lastname: Sykora
authors.forename: Daniel
authors.initials: D
authors.lastname: Göttel
authors.forename: Vincent
authors.initials: V
authors.lastname: Ruland
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hartschuh
authors.forename: Alexander
authors.initials: A
authors.lastname: Enk
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Luger
authors.forename: Stefan
authors.initials: S
authors.lastname: Beissert
authors.forename: Karin
authors.initials: K
authors.lastname: Loser
authors.forename: Stefan
authors.initials: S
authors.lastname: Joos
authors.forename: Peter H
authors.initials: PH
authors.lastname: Krammer
authors.forename: Annegret
authors.initials: A
authors.lastname: Kuhn
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D004817:Epidermis / Q000378:metabolism; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis / Q000378:metabolism*; D008179:Lupus Erythematosus, Discoid / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000378:metabolism*; D053245:RANK Ligand / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D046888:Tissue Array Analysis
chemical_list: D053245:RANK Ligand; C505688:TNFSF11 protein, human