title: Cholecystokinin-producing (I) cells of intestinal mucosa in dexamethasone-treated rats.
abstract: The aim of this study was to investigate the morphological, immunohistochemical and ultrastructural changes of cholecystokinin-producing (I) cells of gastrointestinal mucosa in dexamethasone-treated rats (D). After 12-daily intraperitoneal administration of 2mg/kg dexamethasone, rats developed diabetes similar to human diabetes mellitus type 2. The mean diameter of the duodenum was significantly decreased due to significant reduction of volume fraction and profile area of lamina propria. There was a decrease in volume fraction and number of cholecystokinin (CCK)-producing cells per mm(2) of mucosa, as well as their numerical density, but without statistical significance. Also, dexamethasone induced appearance of hyperactive duodenal I-cells with small number of granules and dilated endoplasmic reticulum. In conclusion, the present study showed that morphological changes in duodenum cholecystokinin-producing (I) cells occurred in diabetic rats, in a manner which, suggests compensatory effort of CCK cells in diabetic condition.
authors.affiliation: Institute of Biology and Ecology Faculty of Science, University of Kragujevac, 34000 Kragujevac, Republic of Serbia.
authors.forename: Radmila
authors.initials: R
authors.lastname: Glišić
authors.forename: Vesna
authors.initials: V
authors.lastname: Koko
authors.forename: Gordana
authors.initials: G
authors.lastname: Cvijić
authors.forename: Maja Čakić
authors.initials: MČ
authors.lastname: Milošević
authors.forename: Jasmina
authors.initials: J
authors.lastname: Obradović
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000473:pathology*; D004386:Duodenum / Q000187:drug effects / Q000473:pathology*; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008297:Male; D011236:Prediabetic State / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003907:Dexamethasone; D002766:Cholecystokinin