title: A small molecule that induces assembly of a four way DNA junction at low temperature.
abstract: Small molecules that induce the formation of higher order DNA structures have potential therapeutic and nanotechnology applications. Screening of a click library has identified the first compound to induce the formation of a Holliday junction structure at room temperature without the need for a high temperature annealing step.
authors.affiliation: School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Howell
authors.forename: Zoë A E
authors.initials: ZA
authors.lastname: Waller
authors.forename: Richard
authors.initials: R
authors.lastname: Bowater
authors.forename: Maria
authors.initials: M
authors.lastname: O'Connell
authors.forename: Mark
authors.initials: M
authors.lastname: Searcey
mesh_terms: D002942:Circular Dichroism; D045566:DNA, Cruciform / Q000737:chemistry*; D005452:Fluoresceins / Q000737:chemistry; D036103:Nanotechnology; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D012235:Rhodamines / Q000737:chemistry; D013696:Temperature
chemical_list: C114557:5-carboxytetramethylrhodamine succinimidyl ester; D045566:DNA, Cruciform; D005452:Fluoresceins; D012235:Rhodamines; C024098:6-carboxyfluorescein