title: Role of the nlrp3 inflammasome in microbial infection.
abstract: The intracellular Nod-like receptor Nlrp3 has emerged as the most versatile innate immune receptor because of its broad specificity in mediating immune response to a wide range of microbial or danger signals. Nlrp3 mediates assembly of the inflammasome complex in the presence of microbial components leading to the activation of caspase-1 and the processing and release of the pro-inflammatory cytokines IL-1β and IL-18. In this review, we give an update on the recent literature examining the role of Nlrp3 inflammasome in response to fungal, bacterial, and viral infections.
authors.affiliation: Department of Immunology, St Jude Children's Research Hospital Memphis, TN, USA.
authors.forename: Paras K
authors.initials: PK
authors.lastname: Anand
authors.forename: R K Subbarao
authors.initials: RK
authors.lastname: Malireddi
authors.forename: Thirumala-Devi
authors.initials: TD
authors.lastname: Kanneganti