title: NO way! Is nitric oxide level in tomato regulated by a mammalian IKK/NF-κB like signaling pathway?
abstract: Nitric oxide (NO) is an essential signaling molecule in plants. However little is known about signaling pathways regulating NO levels in plants. Recently we reported a NO overproducing mutant of tomato that had extremely short roots (shr) at seedling stage. The scavenging of NO restored root elongation in the shr mutant providing us with a convenient bioassay to analyze the signaling pathway upstream of NO production. The application of previously reported pharmacological inhibitors of ubiquitin-proteasome signaling caused a drastic reduction in NO levels and restored root elongation in the mutant. Since these pharmacological inhibitors specifically inhibit mammalian IKK/NF-κB signaling, we propose that a pathway functionally similar to IKK/NF-κB pathway regulates NO levels in tomato.
authors.affiliation: Donald Danforth Plant Science Center, St. Louis, MO, USA.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Negi
authors.forename: Eros V
authors.initials: EV
authors.lastname: Kharshiing
authors.forename: Rameshwar
authors.initials: R
authors.lastname: Sharma
mesh_terms: D051550:I-kappa B Kinase / Q000235:genetics / Q000378:metabolism*; D018551:Solanum lycopersicum / Q000235:genetics / Q000378:metabolism*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
chemical_list: D016328:NF-kappa B; D010940:Plant Proteins; D009569:Nitric Oxide; D051550:I-kappa B Kinase