title: Identification of a new genotype of canine distemper virus circulating in America.
abstract: Canine Distemper is a highly contagious viral systemic disease that affects a wide variety of terrestrial carnivores. Canine Distemper virus (CDV) appears genetically heterogeneous, markedly in the hemagglutinin protein (H), showing geographic patterns of diversification that are useful to monitor CDV molecular epidemiology. In Mexico the activity of canine distemper remains high in dogs, likely because vaccine prophylaxis coverage in canine population is under the levels required to control effectively the disease. By phylogenetic analysis based on the nucleoprotein (N) and on the H genes, Mexican CDV strains collected between 2007 and 2010 were distinguished into several genovariants, all which constituted a unique group, clearly distinct from field and vaccine strains circulating worldwide, but resembling a CDV strain, 19876, identified in Missouri, USA, 2004, that was genetically unrelated to other North-American CDV strains. Gathering information on the genetic heterogeneity of CDV on a global scale appears pivotal in order to investigate the origin and modalities of introduction of unusual/novel CDV strains, as well as to understand if vaccine breakthroughs or disease epidemics may be somewhat related to genetic/antigenic or biological differences between field and vaccine strains.
authors.affiliation: Centro de Investigación y de Estudios Avanzados en Salud Animal, Universidad Autónoma del Estado de México, Toluca, México.
authors.forename: César
authors.initials: C
authors.lastname: Gámiz
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Raúl
authors.initials: R
authors.lastname: Ulloa
authors.forename: Raúl
authors.initials: R
authors.lastname: Fajardo
authors.forename: Israel
authors.initials: I
authors.lastname: Quijano-Hernandéz
authors.forename: Simón
authors.initials: S
authors.lastname: Martínez
mesh_terms: D000818:Animals; D004216:Distemper / Q000235:genetics / Q000276:immunology / Q000821:virology; D004217:Distemper Virus, Canine / Q000145:classification / Q000235:genetics* / Q000276:immunology; D004285:Dogs; D005260:Female; D005838:Genotype; D006389:Hemagglutinins, Viral / Q000235:genetics; D008297:Male; D008800:Mexico; D008969:Molecular Sequence Data; D009698:Nucleoproteins / Q000235:genetics; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D020539:Sequence Analysis, Protein; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D006389:Hemagglutinins, Viral; D009698:Nucleoproteins; D014764:Viral Proteins