title: Design, synthesis, and biological evaluation of a novel class of fluorescein-based N-glycosylamines.
abstract: A series of fluorescein-based N-glycosylamines was synthesized from the corresponding fluorescein amine and a partially protected d-glucose. The physiochemical investigation of these compounds by spectral and morphological studies reveals their gelation potential. The exclusive localization of fluorescence in the cytoplasm through cell imaging studies reveals the anti-cancer potentials of N-glycosylamines.
authors.affiliation: Department of Organic Chemistry, University of Madras, Chennai, India.
authors.forename: Mani
authors.initials: M
authors.lastname: Rajasekar
authors.forename: Sulaiman Mahaboob
authors.initials: SM
authors.lastname: Khan
authors.forename: Sivasithamparam Niranjali
authors.initials: SN
authors.lastname: Devaraj
authors.forename: Thangamuthu Mohan
authors.initials: TM
authors.lastname: Das
mesh_terms: D000588:Amines / Q000737:chemistry; D000606:Amino Sugars / Q000138:chemical synthesis* / Q000737:chemistry*; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D019793:Fluorescein / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D019073:HT29 Cells; D006801:Humans
chemical_list: D000588:Amines; D000606:Amino Sugars; D005947:Glucose; D019793:Fluorescein