title: Physicochemical characterization of α-, β-, and γ-cyclodextrins bioesterified with decanoate chains used as building blocks of colloidal nanoparticles.
abstract: Nanoparticles of amphiphilic α-, β-, and γ-cyclodextrins were obtained by formulation of cyclodextrins enzymatically transesterified with vinyl decanoate. The product of this synthesis is a mixture of bioesterified cyclodextrins with various degrees of substitution (DS) presenting for a same DS different regio-isomers. In a first step, the efficiency of a MALDI-TOF procedure to characterize the average molecular weight of the derivative bulk mixture was demonstrated by comparing the results with those obtained from complementary NMR and HPLC techniques. In a second step, the ultrastructure of nanoparticles prepared from three different batches of synthesis was investigated and correlated with the average molecular weight and DS of the parent derivative.
authors.affiliation: DPM, UMR CNRS 5063, ICMG FR 2607, UFR of Pharmacy, University of Grenoble, France. Luc.choisnard@ujf-grenoble.fr
authors.forename: Luc
authors.initials: L
authors.lastname: Choisnard
authors.forename: Annabelle
authors.initials: A
authors.lastname: Gèze
authors.forename: Cécile
authors.initials: C
authors.lastname: Vanhaverbeke
authors.forename: Josias B G
authors.initials: JB
authors.lastname: Yaméogo
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Putaux
authors.forename: Bernard
authors.initials: B
authors.lastname: Brasme
authors.forename: Laure
authors.initials: L
authors.lastname: Jullien
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Boullanger
authors.forename: Claire
authors.initials: C
authors.lastname: Elfakir
authors.forename: Denis
authors.initials: D
authors.lastname: Wouessidjewe
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003102:Colloids; D003505:Cyclodextrins / Q000737:chemistry*; D003652:Decanoic Acids / Q000737:chemistry*; D004951:Esterification; D057230:Limit of Detection; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D003102:Colloids; D003505:Cyclodextrins; D003652:Decanoic Acids; C031071:decanoic acid