title: Imbalanced estrogen metabolism in the brain: possible relevance to the etiology of Parkinson's disease.
abstract: Damage to DNA by dopamine quinone and/or catechol estrogen quinones may play a significant role in the initiation of Parkinson's disease (PD). Depurinating estrogen-DNA adducts are shed from cells and excreted in urine. The aim of this study was to discover whether higher levels of estrogen-DNA adducts are associated with PD. Forty estrogen metabolites, conjugates, and DNA adducts were analyzed in urine samples from 20 PD cases and 40 matched controls by using ultra performance liquid chromatography/tandem mass spectrometry. The levels of adducts in cases versus controls (P < 0.005) suggest that unbalanced estrogen metabolism could play a causal role in the initiation of PD.
authors.affiliation: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, USA.
authors.forename: Nilesh W
authors.initials: NW
authors.lastname: Gaikwad
authors.forename: Daniel
authors.initials: D
authors.lastname: Murman
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Beseler
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zahid
authors.forename: Eleanor G
authors.initials: EG
authors.lastname: Rogan
authors.forename: Ercole L
authors.initials: EL
authors.lastname: Cavalieri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism*; D002853:Chromatography, Liquid / Q000379:methods; D018736:DNA Adducts / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000209:etiology* / Q000378:metabolism; D052616:Solid Phase Extraction; D053719:Tandem Mass Spectrometry
chemical_list: D018736:DNA Adducts; D004967:Estrogens