title: Use of prebiotics in oral delivery of bioactive compounds: a nanotechnology perspective.
abstract: The oral route is considered the most patient-convenient means of drug administration. In recent years there has been a tendency to employ smart carrier systems that enable controlled or timed release of a bioactive material, thereby providing a better dosing pattern and minimizing side effects. Nano-encapsulation systems (nanocarriers) offer important advantages over conventional drug delivery techniques. Nanocarriers can protect the drug from chemical/enzymatic degradation and enhance bioavailability. Prebiotics are ideal ingredients for the nano-encapsulation and oral drug delivery due to their natural ability to protect the encapsulated compound in the upper gasterointestinal (GI) tract. Here the potential of prebiotics for oral delivery of drugs and other bioactives is reviewed.
authors.affiliation: Department of Chemical and Environmental Engineering, University Putra Malaysia, Selangor, Malaysia.
authors.forename: F
authors.initials: F
authors.lastname: Heidarpour
authors.forename: M R
authors.initials: MR
authors.lastname: Mohammadabadi
authors.forename: I S M
authors.initials: IS
authors.lastname: Zaidul
authors.forename: B
authors.initials: B
authors.lastname: Maherani
authors.forename: N
authors.initials: N
authors.lastname: Saari
authors.forename: A A
authors.initials: AA
authors.lastname: Hamid
authors.forename: F
authors.initials: F
authors.lastname: Abas
authors.forename: M Y A
authors.initials: MY
authors.lastname: Manap
authors.forename: M R
authors.initials: MR
authors.lastname: Mozafari
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016503:Drug Delivery Systems; D005285:Fermentation; D006801:Humans; D036103:Nanotechnology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011134:Polysaccharides / Q000737:chemistry; D056692:Prebiotics; D011355:Prodrugs / Q000008:administration & dosage; D013608:Tablets, Enteric-Coated
chemical_list: D004364:Pharmaceutical Preparations; D011134:Polysaccharides; D056692:Prebiotics; D011355:Prodrugs; D013608:Tablets, Enteric-Coated