title: A case of primary thyroid squamous cell cancer: transformation from benign tumour associated with chronic thyroiditis?
abstract: Primary squamous cell cancer of the thyroid gland (SCT) is a rare malignant tumour and is associated with a high mortality. A female patient who suffered from primary SCT is described in this report. The cancer was identified with acute painful swelling of the thyroid gland, when the patient was under periodical observation for her chronic thyroiditis at our outpatient's clinic. In spite of the highly malignant potential of the cancer as indicated by histological examinations, including p53 and MIB-1 index analyses, the patient has been successfully treated so far with surgery and radiation therapy, surviving for more than 34 months with no sign of recurrence or metastasis. Early diagnosis and prompt treatment might have been essential for the successful management of this patient. Further observations and investigations are necessary to clarify the mechanisms of the long survival and to find a better treatment for the disease.
authors.affiliation: Kumamoto University, Department of Metabolic Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto, 860-8556, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kondo
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsuyoshi
authors.forename: Hidetake
authors.initials: H
authors.lastname: Matsuyoshi
authors.forename: Rieko
authors.initials: R
authors.lastname: Goto
authors.forename: Kaoru
authors.initials: K
authors.lastname: Ono
authors.forename: Yumi
authors.initials: Y
authors.lastname: Honda
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Iyama
authors.forename: Kaku
authors.initials: K
authors.lastname: Tsuruzoe
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Miyamura
authors.forename: Eiichi
authors.initials: E
authors.lastname: Araki