title: Congenital omphalocele and polyhydramnios: a study of 52 cases.
abstract: BACKGROUND
  Unlike gastroschisis, congenital omphalocele is often associated with other anomalies and is frequently complicated by polyhydramnios. We examined the relationships between polyhydramnios, pregnancy outcome and fetal prognosis.
  
  
  METHODS
  Clinical data from cases diagnosed antenatally with congenital omphalocele from 1993 to 2006 were analyzed retrospectively.
  
  
  RESULTS
  Fifty-two cases were diagnosed antenatally with congenital omphalocele, and 38 of these pregnancies resulted in delivered infants. Of these 38 pregnancies, 55.3% were preterm births before 37 weeks of gestation. The mean birth weight was 2,148 g (n = 38). Associated anomalies were recognized in 29 cases (76.3%), including 13 cases (34.2%) of chromosomal aberrations. There were 2 cases of trisomy 13, 10 cases of trisomy 18 and 1 case of trisomy 21. Polyhydramnios was detected in 14 cases (36.8%), and other anomalies were present in all of these cases.
  
  
  CONCLUSIONS
  For antenatal evaluation in cases of congenital omphalocele, it is important to examine the fetus for associated anomalies or underlying disease, especially when polyhydramnios is detected.
authors.affiliation: Division of Obstetrics and Gynecology, Kanagawa Children's Medical Center, Yokohama, Japan.
authors.forename: Katsusuke
authors.initials: K
authors.lastname: Ozawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Maruyama
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nagata
authors.forename: Hiromi
authors.initials: H
authors.lastname: Nagase
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Itani
authors.forename: Kenji
authors.initials: K
authors.lastname: Kurosawa
authors.forename: Michiko
authors.initials: M
authors.lastname: Yamanaka
mesh_terms: D002869:Chromosome Aberrations; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics; D006554:Hernia, Umbilical / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D006831:Polyhydramnios / Q000000981:diagnostic imaging; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D016216:Ultrasonography, Prenatal