title: A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib.
abstract: We report a patient who initially presented with an abdominal paraganglioma and subsequently metastatic papillary cell renal cancer. Genetic analysis revealed a 141 G>A (exon 2) Trp47X mutation within the succinate dehydrogenase B gene. Treatment with the novel multi-targeted tyrosine kinase inhibitor sunitinib resulted in a sustained partial response and reduced the level of the angiogenic marker PIGF.
  
  
  BACKGROUND
  a6181037.
authors.affiliation: Royal Marsden NHS Foundation Trust, Medical Oncology, London, SW3 6JJ, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Tuthill
authors.forename: Ravi
authors.initials: R
authors.lastname: Barod
authors.forename: Linda
authors.initials: L
authors.lastname: Pyle
authors.forename: Terry
authors.initials: T
authors.lastname: Cook
authors.forename: Shern
authors.initials: S
authors.lastname: Chew
authors.forename: Martin
authors.initials: M
authors.lastname: Gore
authors.forename: Patrick
authors.initials: P
authors.lastname: Maxwell
authors.forename: Tim
authors.initials: T
authors.lastname: Eisen