title: Glia instruct developmental neuronal remodeling through TGF-β signaling.
abstract: We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.
authors.affiliation: Department of Neurobiology, University of Massachusetts, Worcester, Massachusetts, USA. awasakit@janelia.hhmi.org
authors.forename: Takeshi
authors.initials: T
authors.lastname: Awasaki
authors.forename: Yaling
authors.initials: Y
authors.lastname: Huang
authors.forename: Michael B
authors.initials: MB
authors.lastname: O'Connor
authors.forename: Tzumin
authors.initials: T
authors.lastname: Lee
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology*; D049452:Green Fluorescent Proteins / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008959:Models, Neurological; D024521:Mushroom Bodies / Q000166:cytology* / Q000254:growth & development; D009154:Mutation / Q000235:genetics; D055495:Neurogenesis / Q000235:genetics; D009457:Neuroglia / Q000502:physiology*; D012330:RNA, Double-Stranded / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D035683:MicroRNAs; D012330:RNA, Double-Stranded; D016212:Transforming Growth Factor beta; C121965:myo protein, Drosophila; D049452:Green Fluorescent Proteins