title: Proton pump inhibitors therapy and risk of hip fracture: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Previous studies have reported inconsistent findings that proton pump inhibitors (PPIs) therapy might increase the risk of hip fracture. We investigated the association between PPIs therapy and hip fracture by a systematic review and meta-analysis.
  
  
  METHODS
  We systematically searched PubMed, EMBASE, and the Cochrane Library. We included studies assessing the effects of PPIs on hip fracture. Data from the studies about odds ratio and 95% confidence interval were gathered and summarized.
  
  
  RESULTS
  Seven studies met the inclusion criteria. PPIs therapy was associated with a statistically significant increase of hip fracture risk (pooled odds ratio=1.24; 95% confidence interval: 1.15-1.34; P<0.00001) under a random model. Meanwhile, we found that the effect of PPIs on hip fracture differs in different duration groups.
  
  
  CONCLUSIONS
  These results indicate that PPIs therapy might have the potential risk of hip fracture. Different effects on hip fracture in the subgroup analysis do not support a causal relationship between PPIs and hip fracture. Whether the risk exists warrants further investigation.
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Ye
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Cheng
authors.initials: C
authors.lastname: Wu
authors.forename: Yingyi
authors.initials: Y
authors.lastname: Qin
authors.forename: Jiajie
authors.initials: J
authors.lastname: Zang
authors.forename: Qingbin
authors.initials: Q
authors.lastname: Gao
authors.forename: Xinji
authors.initials: X
authors.lastname: Zhang
authors.forename: Jia
authors.initials: J
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004334:Drug Administration Schedule; D006620:Hip Fractures / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D012107:Research Design; D018570:Risk Assessment / Q000379:methods; D055815:Young Adult
chemical_list: D054328:Proton Pump Inhibitors