title: Development of an advanced database for clinical trials integrated with an electronic patient record system.
abstract: Secondary use of patient databases is essential in healthcare if clinical trials are to progress efficiently to planned time and target and imperative if the planned UK expansion of research and development (R&D) at point of care is to be achieved. Integration of effective databases primarily designed to facilitate patient care with R&D requirements is needed but represents a complex challenge. We present a system that achieves an integrated approach with online management of complex datasets for clinical trials within care records using a specific study as an example to show functionality in practice; illustrating how this system provides an ideal resource to meet the needs of both clinicians and researchers.
authors.affiliation: Cancer Research UK Clinical Centre, University of Leeds, St James's Institute of Oncology, Beckett Street, Leeds, West Yorkshire, LS9 7TF, UK.
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Newsham
authors.forename: Colin
authors.initials: C
authors.lastname: Johnston
authors.forename: Geoff
authors.initials: G
authors.lastname: Hall
authors.forename: Michael G
authors.initials: MG
authors.lastname: Leahy
authors.forename: Adam B
authors.initials: AB
authors.lastname: Smith
authors.forename: Aditya
authors.initials: A
authors.lastname: Vikram
authors.forename: Aine M
authors.initials: AM
authors.lastname: Donnelly
authors.forename: Galina
authors.initials: G
authors.lastname: Velikova
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Selby
authors.forename: Sheila E
authors.initials: SE
authors.lastname: Fisher
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D003628:Database Management Systems; D016208:Databases, Factual; D057286:Electronic Health Records; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D011795:Surveys and Questionnaires; D014584:User-Computer Interface