title: Correlation analysis of quantitative diffusion parameters in ipsilateral cerebral peduncle during Wallerian degeneration with motor function outcome after cerebral ischemic stroke.
abstract: OBJECTIVE
  To evaluate the time periods of Wallerian degeneration (WD) in which the diffusion parameters of ipsilateral corticalspinal tract (CST) can be used to predict the motor function outcome after brain infarction.
  
  
  METHODS
  This retrospective study classified 48 diffusion tensor imaging patients with WD along CST into four groups based on the following time points after stroke onset, Group 1: within the first 2 weeks; Group 2: from 3 to 4 weeks; Group 3: from 5 to 14 weeks; Group 4: after 14 weeks. The apparent diffusion coefficient (ADC), fractional anisotropy (FA), and their ratios (=ipsilateral diffusion value/contralateral value) of cerebral peduncle were evaluated. The correlation between imaging parameters in each group and the motor function scores appraised at 8 months after stroke onset were assessed.
  
  
  RESULTS
  There was no evident correlation of FA ratio (rFA) in Group 1 with motor function score (P = .05). The rFA and FA correlated with motor function score in other groups (P < .001 in each group). The ADC ratio and ipsilateral ADC value only showed significant correlation of with motor function score in Group 4 (P= .016 and .029, respectively).
  
  
  CONCLUSIONS
  The rFA and ipsilateral FA values after 2 weeks of stroke onset correlate with the motor function outcome.
authors.affiliation: Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642-8638, USA. Xiang_Liu@URMC.Rochester.edu
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Tian
authors.forename: Xing
authors.initials: X
authors.lastname: Qiu
authors.forename: Juntao
authors.initials: J
authors.lastname: Li
authors.forename: Scott
authors.initials: S
authors.lastname: Thomson
authors.forename: Lilin
authors.initials: L
authors.lastname: Li
authors.forename: Henry Z
authors.initials: HZ
authors.lastname: Wang
mesh_terms: D002545:Brain Ischemia / Q000150:complications / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D020521:Stroke / Q000209:etiology / Q000473:pathology*; D013681:Tegmentum Mesencephali / Q000473:pathology*; D014855:Wallerian Degeneration / Q000150:complications / Q000473:pathology*