title: Nucleic acid-based therapeutics for glioblastoma.
abstract: Nucleic acid based therapeutics offer the possibility of tailor-made treatment of malignant diseases. For recurrent glioblastoma multiforme (GBM), the most aggressive type of brain tumor, no accepted treatment exists, making therapeutically active nucleic acids a viable option. In this review, current preclinical and clinical studies harnessing the potential of antitumoral nucleic acids for GBM treatment will be considered. These include gene therapy to over-express antitumoral gene products, RNA interference to knock down components that promote tumor progression, and the tumor-targeted delivery of antitumoral double stranded RNA. Vectors applied in GBM for the delivery of nucleic acids will be discussed. These include non-replicating and replicating (oncolytic) viruses, as well as non-viral delivery vectors based on polycations or cationic lipids.
authors.affiliation: Unit of Cellular Signaling, Department of Biological Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel. alexeis@cc.huji.ac.il
authors.forename: Alexei
authors.initials: A
authors.lastname: Shir
authors.forename: Alexander
authors.initials: A
authors.lastname: Levitzki
authors.forename: Ernst
authors.initials: E
authors.lastname: Wagner
authors.forename: Shoshana
authors.initials: S
authors.lastname: Klein
authors.forename: Manfred
authors.initials: M
authors.lastname: Ogris
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics; D016503:Drug Delivery Systems / Q000379:methods; D018014:Gene Transfer Techniques; D005909:Glioblastoma / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D009696:Nucleic Acids / Q000008:administration & dosage* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D009696:Nucleic Acids