title: Extensively drug resistant tuberculosis in a 7-year-old child with interferon-γ and interleukin-12 deficiency.
abstract: Defects in interferon-γ axis have been shown to be associated with disseminated mycobacterial disease. A case of a previously healthy HIV seronegative child with disseminated extensively drug resistant Mycobacterium tuberculosis infection presenting as splenic abscesses with lymphadenopathy and progressing to disseminated tuberculosis with absent interferon-γ and interleukin-12 production is reported here.
authors.affiliation: Department of Pediatrics, Advanced Pediatrics Center, PGIMER, Chandigarh, 160012, India.
authors.forename: Ketan
authors.initials: K
authors.lastname: Kulkarni
authors.forename: Meenu
authors.initials: M
authors.lastname: Singh
authors.forename: Pooja
authors.initials: P
authors.lastname: Soneja
authors.forename: Joseph
authors.initials: J
authors.lastname: Mathew
authors.forename: Ram Kumar
authors.initials: RK
authors.lastname: Marwaha