title: Contributions of area Te2 to rat recognition memory.
abstract: Ablations and local intracerebral infusions were used to determine the role of rat temporal association cortex (area Te2) in object recognition memory, so that this role might be compared with that of the adjacent perirhinal cortex (PRH). Bilateral lesions of Te2 impaired recognition memory measured by preferential exploration of a novel rather than a familiar object at delays ≥20 min but not after a 5-min delay. Local infusion bilaterally into Te2 of (1) CNQX to block AMPA/kainate receptors or (2) lidocaine to block axonal transmission or (3) AP5, an NMDA receptor antagonist, impaired recognition memory after a 24-h but not a 20-min delay. In PRH all these manipulations impair recognition memory after a 20-min as well as a 24-h delay. UBP302, a GluK1 kainate receptor antagonist, impaired recognition memory after a 24-h but not a 20-min delay, contrasting with its action in PRH where it impairs only shorter-term (20 min) recognition memory. Also in contrast to PRH, infusion of the muscarinic receptor antagonist scopolamine was without effect. The Te2 impairments could not readily be ascribed to perceptual deficits. Hence, Te2 is essential for object recognition memory at delays >5 or 20 min. Thus, at long delays both area Te2 and PRH are necessary for object recognition memory.
authors.affiliation: MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom.
authors.forename: Jonathan Weng-Thim
authors.initials: JW
authors.lastname: Ho
authors.forename: Katherine Elizabeth
authors.initials: KE
authors.lastname: Narduzzo
authors.forename: Alexandra
authors.initials: A
authors.lastname: Outram
authors.forename: Christopher John
authors.initials: CJ
authors.lastname: Tinsley
authors.forename: Jeremy Martin
authors.initials: JM
authors.lastname: Henley
authors.forename: Elizabeth Clea
authors.initials: EC
authors.lastname: Warburton
authors.forename: Malcolm Watson
authors.initials: MW
authors.lastname: Brown
mesh_terms: D000818:Animals; D008297:Male; D008568:Memory / Q000502:physiology*; D051381:Rats; D021641:Recognition, Psychology / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*