title: Biosensors based on combined optical and electrochemical transduction for molecular diagnostics.
abstract: Electrochemical and optical biosensors exist to monitor different fluids containing analytes of interest. Until today, these have been developed separately. Owing to the creation of new transducer configurations such as indium tin-coated glass fiber optics, these methods can now be used separately, in parallel and it is hoped that one day they will be able to be used simultaneously; thus, using the same probe to measure a single analyte using two different methods (electrochemical and optical) or two different analytes with either of the aforementioned methods sitting on the same probe. This article will highlight the importance, as well as the usefulness, of combining measurement methodologies in improving sensor response and sensitivity.
authors.affiliation: Unit of Environmental Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Evgeni
authors.initials: E
authors.lastname: Eltzov
authors.forename: Serge
authors.initials: S
authors.lastname: Cosnier
authors.forename: Robert S
authors.initials: RS
authors.lastname: Marks
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000639:trends; D015342:DNA Probes; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004800:Enzymes, Immobilized; D005336:Fiber Optic Technology / Q000295:instrumentation*; D005455:Fluorescent Antibody Technique / Q000295:instrumentation; D008163:Luminescent Measurements / Q000295:instrumentation; D025202:Molecular Diagnostic Techniques / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation; D020349:Surface Plasmon Resonance; D014159:Transducers
chemical_list: D015342:DNA Probes; D004800:Enzymes, Immobilized