title: Epidemiology of Candida blood stream infections in patients with hematological malignancies or solid tumors.
abstract: Invasive Candida infections are associated with high morbidity and mortality. Due to an increased incidence in patients with hematological or oncological malignancies, fluconazole prophylaxis became a common practice in many centers in the late 1990s. Until recently, there was insufficient data on the effect of the use of azoles on the incidence of Candida blood stream infections and species distribution. Here we present a single center retrospective study of the epidemiology of Candida blood stream infections in hospitalized patients at a German university medical center from 2003-2009. Twenty-one Candida species were isolated in culture from blood specimens of 20 patients. The annual rate of candidemia approached 1.1 per thousand hospitalizations, during the first 5 years of the survey, but showed a significant increase after 2007. Candida albicans, although still the dominant species, was recovered as the responsible pathogen from only 28.6% of the cases. A high rate of fatal outcomes was noted at 30 days (56%) and 100 days (67%) after the first positive finding of Candida in blood culture. These results underline the clinical significance of this infectious complication, and the need for continuous monitoring for Candida blood stream infections in order to improve the clinical and therapeutic management of this specific patient population.
authors.affiliation: Department of Internal Medicine II, University of Würzburg Medical Center, Würzburg, Germany.
authors.forename: Janina
authors.initials: J
authors.lastname: Zirkel
authors.forename: Hartwig
authors.initials: H
authors.lastname: Klinker
authors.forename: Anna
authors.initials: A
authors.lastname: Kuhn
authors.forename: Marianne
authors.initials: M
authors.lastname: Abele-Horn
authors.forename: Dennis
authors.initials: D
authors.lastname: Tappe
authors.forename: Doris
authors.initials: D
authors.lastname: Turnwald
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
authors.forename: Werner J
authors.initials: WJ
authors.lastname: Heinz
mesh_terms: D001769:Blood / Q000382:microbiology*; D002175:Candida / Q000302:isolation & purification*; D058387:Candidemia / Q000453:epidemiology* / Q000382:microbiology*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D012189:Retrospective Studies