title: Critical comparison of diffuse reflectance spectroscopy and colorimetry as dermatological diagnostic tools for acanthosis nigricans: a chemometric approach.
abstract: Quantification of skin changes due to acanthosis nigricans (AN), a disorder common among insulin-resistant diabetic and obese individuals, was investigated using two optical techniques: diffuse reflectance spectroscopy (DRS) and colorimetry. Measurements were obtained from AN lesions on the neck and two control sites of eight AN patients. A principal component/discriminant function analysis successfully differentiated between AN lesion and normal skin with 87.7% sensitivity and 94.8% specificity in DRS measurements and 97.2% sensitivity and 96.4% specificity in colorimetry measurements.
authors.forename: Suneetha
authors.initials: S
authors.lastname: Devpura
authors.forename: Bensachee
authors.initials: B
authors.lastname: Pattamadilok
authors.forename: Zain U
authors.initials: ZU
authors.lastname: Syed
authors.forename: Pranita
authors.initials: P
authors.lastname: Vemulapalli
authors.forename: Marsha
authors.initials: M
authors.lastname: Henderson
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Rehse
authors.forename: Iltefat
authors.initials: I
authors.lastname: Hamzavi
authors.forename: Henry W
authors.initials: HW
authors.lastname: Lim
authors.forename: Ratna
authors.initials: R
authors.lastname: Naik