title: A B1-insensitive high resolution 2D T1 mapping pulse sequence for dGEMRIC of the HIP at 3 Tesla.
abstract: Early detection of cartilage degeneration in the hip may help prevent onset and progression of osteoarthritis in young patients with femoroacetabular impingement. Delayed gadolinium-enhanced MRI of cartilage is sensitive to cartilage glycosaminoglycan loss and could serve as a diagnostic tool for early cartilage degeneration. We propose a new high resolution 2D T1 mapping saturation-recovery pulse sequence with fast spin echo readout for delayed gadolinium-enhanced magnetic resonance imaging of cartilage of the hip at 3 T. The proposed sequence was validated in a phantom and in 10 hips, using radial imaging planes, against a rigorous multipoint saturation-recovery pulse sequence with fast spin echo readout. T1 measurements by the two pulse sequences were strongly correlated (R2>0.95) and in excellent agreement (mean difference=-8.7 ms; upper and lower 95% limits of agreement=64.5 and -81.9 ms, respectively). T1 measurements were insensitive to B1+ variation as large as 20%, making the proposed T1 mapping technique suitable for 3 T.
authors.affiliation: Department of Radiology, Center for Biomedical Imaging, New York University Langone Medical Center, New York, New York 10016, USA. riccardo.lattanzi@nyumc.org
authors.forename: Riccardo
authors.initials: R
authors.lastname: Lattanzi
authors.forename: Christian
authors.initials: C
authors.lastname: Glaser
authors.forename: Artem V
authors.initials: AV
authors.lastname: Mikheev
authors.forename: Catherine
authors.initials: C
authors.lastname: Petchprapa
authors.forename: David J
authors.initials: DJ
authors.lastname: Mossa
authors.forename: Soterios
authors.initials: S
authors.lastname: Gyftopoulos
authors.forename: Henry
authors.initials: H
authors.lastname: Rusinek
authors.forename: Michael
authors.initials: M
authors.lastname: Recht
authors.forename: Daniel
authors.initials: D
authors.lastname: Kim
mesh_terms: D000328:Adult; D000465:Algorithms; D003287:Contrast Media; D005260:Female; D057925:Femoracetabular Impingement / Q000175:diagnosis*; D019786:Gadolinium DTPA; D006621:Hip Joint / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA