title: No association between affective and behavioral dysregulation and parameters of thyroid function in youths.
abstract: OBJECTIVE
  Evidence from adults suggests that changes in thyroid function are associated with the development of bipolar disorder (BD) and severe mood dysregulation. A dysregulation profile based on the Child Behavior Checklist (CBCL-DP) describes a phenotype with severe mood problems in youth. The present study investigated whether altered thyroid functioning in youths is associated with the severe mood dysregulation symptoms characterized by the CBCL-DP.
  
  
  METHODS
  We analyzed the thyroid function data from 262 children and adolescents (n = 262 for serum TSH, n = 148 for free triiodothyronine [fT3] and n = 153 for free thyroxine [fT4]) with their CBCL-DP composite score. We created and compared high CBCL-DP and low CBCL-DP subgroups with regard to their serum TSH, fT3 and fT4 concentrations as well as the presence or absence of subclinical hypothyroidism.
  
  
  RESULTS
  We did not detect between-group differences in serum TSH, fT3 and fT4 concentrations, nor were there significant correlations between youths' CBCL-DP scores and their serum TSH, fT3 and fT4 concentrations for either the whole sample or any subgroup. Post-hoc power analyses indicated that adequate to moderate power existed to detect between-group differences in fT3 and fT4 concentrations, respectively, but that larger TSH samples would be required to detect the same differences in those concentrations.
  
  
  CONCLUSIONS
  This study had a retrospective design, fewer females than males, and reduced power with respect to TSH concentrations.
  
  
  CONCLUSIONS
  The present investigation does not support the association between elevated serum-TSH concentrations and severe mood dysregulation in youths. However, these findings should be confirmed in future large-scale studies.
authors.affiliation: Department of Child and Adolescent Psychiatry, RWTH University of Aachen, Germany. fzepf@ukaachen.de
authors.forename: F D
authors.initials: FD
authors.lastname: Zepf
authors.forename: T D
authors.initials: TD
authors.lastname: Vloet
authors.forename: G G
authors.initials: GG
authors.lastname: Polier
authors.forename: D
authors.initials: D
authors.lastname: Baurmann
authors.forename: S
authors.initials: S
authors.lastname: Bubenzer
authors.forename: K
authors.initials: K
authors.lastname: Helmbold
authors.forename: T J
authors.initials: TJ
authors.lastname: Gaber
authors.forename: T
authors.initials: T
authors.lastname: Schmidt
authors.forename: B
authors.initials: B
authors.lastname: Herpertz-Dahlmann
authors.forename: L
authors.initials: L
authors.lastname: Wöckel
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder; D002648:Child; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000523:psychology*; D007037:Hypothyroidism / Q000097:blood / Q000523:psychology; D008297:Male; D019964:Mood Disorders / Q000097:blood*; D012189:Retrospective Studies; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine