title: Novel terpene based 1,4,2-dioxazoles: synthesis, characterization, molecular properties and screening against Entamoeba histolytica.
abstract: In present investigation a series of 20 dioxazole analogues (1-20) were synthesized, characterized and subjected to molecular properties prediction, anti-amoebic screening and cytotoxicity evaluation. Out of the twenty compounds viz. 3,5-substituted-1,4,2-dioxazoles, six compounds have shown IC(50) values in the range (1.00-1.10 μM) lower than the standard drug metronidazole (IC(50) = 1.45 μM). The toxicological studies of the active compounds on H9c2 rat cardiac myoblasts showed that all compounds were nontoxic. The pKa, and log P values have also been predicted. Compound 8 showed the most promising results based on anti-amoebic evaluation, cytotoxicity studies and physico-chemical properties prediction.
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.
authors.forename: Mohmmad
authors.initials: M
authors.lastname: Younus Wani
authors.forename: Fareeda
authors.initials: F
authors.lastname: Athar
authors.forename: Attar
authors.initials: A
authors.lastname: Salauddin
authors.forename: Subhash
authors.initials: S
authors.lastname: Mohan Agarwal
authors.forename: Amir
authors.initials: A
authors.lastname: Azam
authors.forename: Inho
authors.initials: I
authors.lastname: Choi
authors.forename: Abdul
authors.initials: A
authors.lastname: Roouf Bhat
mesh_terms: D000818:Animals; D004748:Entamoeba histolytica / Q000187:drug effects*; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry*
chemical_list: D010080:Oxazoles; D013729:Terpenes