title: [Photodynamic therapy and urothelial carcinoma].
abstract: OBJECTIVE
  Photodynamic therapy (PDT) is an innovative therapeutic modality in urologic oncology.
  
  
  METHODS
  We reviewed the current literature on principles and modalities of PDT in urothelial and penile oncology.
  
  
  RESULTS
  PDT has been tested for the treatment recurrent superficial bladder tumors and in situ carcinoma. Carcinologic efficacy has been observed with first generation photosensitizer. The lack of selectivity for tumoral cells was responsible of serious adverse events. Development of selective photosensitizers has reduced the importance of side effects. Data concerning PDT for upper urinary tract and urethra carcinoma are still limited.
  
  
  CONCLUSIONS
  First PDT clinical applications in urothelial oncology have shown some effectiveness at the cost of significant morbidity. The development of selective photosensitizers should help to reduce side effects.
authors.affiliation: Université Nord de France, unité U703, Inserm, 152, rue du Docteur-Yersin, 59120 Loos, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Colin
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Estevez
authors.forename: Nacim
authors.initials: N
authors.lastname: Betrouni
authors.forename: Pierre
authors.initials: P
authors.lastname: Nevoux
authors.forename: Philippe
authors.initials: P
authors.lastname: Puech
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
authors.forename: Jacques
authors.initials: J
authors.lastname: Biserte
authors.forename: Arnauld
authors.initials: A
authors.lastname: Villers
authors.forename: Serge
authors.initials: S
authors.lastname: Mordon
mesh_terms: D002278:Carcinoma in Situ / Q000188:drug therapy; D006801:Humans; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods*; D017319:Photosensitizing Agents / Q000009:adverse effects / Q000627:therapeutic use*; D014516:Ureteral Neoplasms / Q000188:drug therapy; D014523:Urethral Neoplasms / Q000188:drug therapy; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy; D014571:Urologic Neoplasms / Q000188:drug therapy*
chemical_list: D017319:Photosensitizing Agents