title: Incidence of intussusception in early infancy: a capture-recapture estimate for Germany.
abstract: BACKGROUND
  Rotavirus (RV) vaccination with the first generation vaccine (Rotashield) has been associated with intussusception (IS). Reliable age specific baseline incidence data for children ≤6 months of age in particular is fundamental for further post marketing monitoring of potential effects of recently introduced new RV vaccines.
  
  
  METHODS
  IS incidence was estimated by a 2-source capture-recapture calculation (CRC) based on ESPED (German Paediatric Surveillance Unit) reports and on hospital discharge records for 2006 and 2007. ESPED as well as hospital records were validated according to the Brighton Collaboration's Group definition for definite IS.
  
  
  METHODS
  Children that have been treated for IS in a hospital in one of two states of Germany (North-Rhine Westphalia and Bavaria).
  
  
  RESULTS
  The annual IS incidence for infants <1 year in Germany calculated with the CRC estimate in Germany was 61.7/100 000 (95% CI: 54.5-70.1). However, the incidence appeared to vary by month of age over a range of 19.2/100 000 cases (95% CI: 12.5-30.4) in the first 3 months of life to 98.5/100 000 cases (95% CI: 80.9-120.6) during the 6 (th) to 8 (th) month. The male to female ratio for infants was 1.7:1 (95%CI: 1.6-1.8).
  
  
  CONCLUSIONS
  The average incidence estimate for IS in infants (< 1 year) confirms previous estimates in Germany and Switzerland. However, age specific baseline incidence estimates for IS substantially vary during the first year of life. This has to be taken into account when analysing episodes of IS potentially associated with RV vaccination.
authors.affiliation: Ludwig-Maximilians-Universität München, Institute for Social Paediatrics and Adolescent Medicine, Germany. susanne.weiss@med.uni-muenchen.de
authors.forename: S
authors.initials: S
authors.lastname: Weiß
authors.forename: A
authors.initials: A
authors.lastname: Streng
authors.forename: R von
authors.initials: Rv
authors.lastname: Kries
authors.forename: J
authors.initials: J
authors.lastname: Liese
authors.forename: S
authors.initials: S
authors.lastname: Wirth
authors.forename: A C
authors.initials: AC
authors.lastname: Jenke
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000367:Age Factors; D003430:Cross-Sectional Studies; D057915:Drug Substitution; D005260:Female; D005858:Germany; D006753:Hospital Records / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D007443:Intussusception / Q000139:chemically induced / Q000453:epidemiology*; D008297:Male; D011159:Population Surveillance; D011358:Product Surveillance, Postmarketing; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D013223:Statistics as Topic; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: C492457:RIX4414 vaccine; C492535:RotaTeq; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated