title: The protective effects of β-lactam antibiotics in motor neuron disorders.
abstract: In the June issue of Experimental Neurology, Nizzardo and colleagues demonstrate that the beta-lactam antibiotic ceftriaxone is neuroprotective in a mouse model of spinal muscular atrophy. Here I review their main findings and the relevance to previous and future work on motor neuron disorders and for developing therapeutic strategies.
authors.affiliation: Ludwig Institute for Cancer Research, Karolinska Institutet, Nobelsv 3, 171 77 Stockholm, Sweden. eva.hedlund@licr.ki.se
authors.forename: Eva
authors.initials: E
authors.lastname: Hedlund
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000627:therapeutic use*; D009046:Motor Neurons / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects*; D009134:Muscular Atrophy, Spinal / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D018696:Neuroprotective Agents; D002443:Ceftriaxone