title: Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids.
abstract: To investigate the effect of n-3 polyunsaturated fatty acid (PUFA) supplementation on the fatty acid composition of erythrocyte phospholipids and breast milk lipids, pregnant Brazilian women in the 30th week of gestation were randomized to supplement their usual diet with 2 g/day of fish oil (FO group) or primrose oil (PO group, control) capsules for 15 days. Erythrocyte phospholipids from FO group had proportionally higher docosahexaenoicacid and eicosapentaenoic acid levels and furthermore, the ratio of n-6/n-3 PUFA was significantly lower in the breast milk lipids compared with the control group. Assessment of plasma anti-oxLDL autoantibodies and thiobarbituric acid-reactive substance concentration demonstrated that both groups had the same levels and they were unaltered by supplementations.
authors.affiliation: Nove de Julho University, Rua Vergueiro 235, CEP 01504-000 São Paulo, SP, Brazil.
authors.forename: Pérola
authors.initials: P
authors.lastname: Ribeiro
authors.forename: Fernanda Daniela Fernandes
authors.initials: FD
authors.lastname: Carvalho
authors.forename: Amanda de Amaro
authors.initials: Ade A
authors.lastname: Abreu
authors.forename: Marcela de Toledo
authors.initials: Mde T
authors.lastname: Sant'anna
authors.forename: Rosemary Joana de
authors.initials: RJ
authors.lastname: Lima
authors.forename: Patrícia de Oliveira
authors.initials: Pde O
authors.lastname: Carvalho
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001938:Brazil; D008078:Cholesterol, LDL / Q000097:blood / Q000276:immunology; D004032:Diet; D004041:Dietary Fats / Q000378:metabolism; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000378:metabolism / Q000494:pharmacology; D015118:Eicosapentaenoic Acid / Q000378:metabolism / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000494:pharmacology*; D043371:Fatty Acids, Omega-6 / Q000378:metabolism; D005260:Female; D006801:Humans; D008041:Linoleic Acids / Q000378:metabolism / Q000494:pharmacology*; D008895:Milk, Human / Q000378:metabolism*; D031665:Oenothera biennis; D010743:Phospholipids / Q000097:blood*; D010938:Plant Oils / Q000378:metabolism / Q000494:pharmacology*; D011247:Pregnancy / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D055815:Young Adult; D017965:gamma-Linolenic Acid / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D001323:Autoantibodies; D008078:Cholesterol, LDL; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D008041:Linoleic Acids; D010743:Phospholipids; D010938:Plant Oils; D017392:Thiobarbituric Acid Reactive Substances; D004281:Docosahexaenoic Acids; C028498:evening primrose oil; D017965:gamma-Linolenic Acid; D015118:Eicosapentaenoic Acid