title: Determination of pentapeptide repeat units in Qnr proteins by the structure-based alignment approach.
abstract: The Qnr proteins belong to the pentapeptide repeat protein family. Despite each pentapeptide repeat unit being an important structural determinant, accurately determining pentapeptide repeat units in the Qnr proteins through sequence-based alignments has been challenging. In the present study, the pentapeptide repeat units of the nine representative Qnr proteins have been precisely determined via the structure-based alignment approach using homology modeling and superposition of their best models.
authors.affiliation: Drug Resistance Proteomics Laboratory, Department of Biological Sciences, Myongji University, San 38-2 Namdong, Yongin, Gyeonggido 449-728, Republic of Korea.
authors.forename: Kwang Seung
authors.initials: KS
authors.lastname: Park
authors.forename: Jung Hun
authors.initials: JH
authors.lastname: Lee
authors.forename: Da Un
authors.initials: DU
authors.lastname: Jeong
authors.forename: Jae Jin
authors.initials: JJ
authors.lastname: Lee
authors.forename: Xing
authors.initials: X
authors.lastname: Wu
authors.forename: Byeong Chul
authors.initials: BC
authors.lastname: Jeong
authors.forename: Choong-Min
authors.initials: CM
authors.lastname: Kang
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D017433:Protein Structure, Secondary; D015363:Quinolones / Q000494:pharmacology; D017386:Sequence Homology, Amino Acid
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D009842:Oligopeptides; D015363:Quinolones