title: Stuck in the middle: drugging the ubiquitin system at the e2 step.
abstract: The discovery of a small-molecule allosteric inhibitor of the CDC34 ubiquitin-conjugating enzyme (E2) by Ceccarelli et al. raises the possibility that it will be generally feasible to selectively inhibit ubiquitin transfer at this central step in the ubiquitin pathway.
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. wade_harper@hms.harvard.edu
authors.forename: J Wade
authors.initials: JW
authors.lastname: Harper
authors.forename: Randall W
authors.initials: RW
authors.lastname: King