title: Genetic pathways leading to therapy-related myeloid neoplasms.
abstract: Therapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy. t-MN arises in most cases from a multipotential hematopoietic stem cell or, less commonly, in a lineage committed progenitor cell. The prognosis for patients with t-MN is poor, as current forms of therapy are largely ineffective. Cytogenetic analysis, molecular analysis and gene expression profiling analysis of t-MN has revealed that there are distinct subtypes of the disease; however, our understanding of the genetic basis of t-MN is incomplete. Elucidating the genetic pathways and molecular networks that are perturbed in t-MNs, may facilitate the identification of therapeutic targets that can be exploited for the development of urgently-needed targeted therapies.
authors.affiliation: University of Chicago, Chicago, IL, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Stoddart
authors.forename: Megan E
authors.initials: ME
authors.lastname: McNerney
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Bartom
authors.forename: Rachel
authors.initials: R
authors.lastname: Bergerson
authors.forename: David J
authors.initials: DJ
authors.lastname: Young
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Qian
authors.forename: Jianghong
authors.initials: J
authors.lastname: Wang
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Fernald
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Davis
authors.forename: Richard A
authors.initials: RA
authors.lastname: Larson
authors.forename: Kevin P
authors.initials: KP
authors.lastname: White
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Le Beau