title: Ru/Me-BIPAM-catalyzed asymmetric addition of arylboronic acids to aliphatic aldehydes and α-ketoesters.
abstract: A ruthenium-catalyzed asymmetric arylation of aliphatic aldehydes and α-ketoesters with arylboronic acids has been developed, giving chiral alkyl(aryl)methanols and α-hydroxy esters in good yields. The use of a chiral bidentate phosphoramidite ligand (Me-BIPAM) achieved excellent enantioselectivities.
authors.affiliation: Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Kita 13 Nishi 8 Kita-ku, Sapporo, Japan. yasuyama@eng.hokudai.ac.jp
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Shirai
authors.forename: Momoko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kurihara
authors.forename: Norio
authors.initials: N
authors.lastname: Miyaura
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D009943:Organophosphorus Compounds / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D001897:Boronic Acids; D004952:Esters; D007659:Ketones; D008024:Ligands; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D012428:Ruthenium