title: An electrochemical synthesis of functionalized arylpyrimidines from 4-amino-6-chloropyrimidines and aryl halides.
abstract: A range of novel 4-amino-6-arylpyrimidines has been prepared under mild conditions by an electrochemical reductive cross-coupling between 4-amino-6-chloro-pyrimidines and functionalized aryl halides. The process, which employs a sacrificial iron anode in conjunction with a nickel(II) catalyst, allows the formation of coupling products in moderate to high yields.
authors.affiliation: Electrochimie et Synthèse Organique, Institut de Chimie et des Matériaux Paris-Est (ICMPE), UMR 7182, CNRS, Université Paris-Est Créteil Val-de-Marne, 2-8 Rue Henri Dunant, 94320 Thiais, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Sengmany
authors.forename: Erwan
authors.initials: E
authors.lastname: Le Gall
authors.forename: Eric
authors.initials: E
authors.lastname: Léonel
mesh_terms: D002384:Catalysis; D004563:Electrochemistry / Q000379:methods*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011743:Pyrimidines; D009532:Nickel