title: [Depyrogenation in key manufacturing processes of Reduning injection].
abstract: OBJECTIVE
  To investigate the effect of removing bacterial endotoxin in the key processes of Reduning injection.
  
  
  METHODS
  The content of bacterial endotoxins was detected by kenitic-turbidimetry and the removal efficacy was studied before and after using 0.8% of activated carbon and ultrafiltration with molecular weight cut-off of 10 x 10(3).
  
  
  RESULTS
  The adsorption rate of bacterial endotoxins was 78.7% by using activated carbon, while the removal efficacy of bacterial endotoxins was 99.6% with ultrafiltration membrane at cut-off molecular weight 10 x 10(3).
  
  
  CONCLUSIONS
  The key technology can effectively guarantee the safety of Reduning injection.
authors.affiliation: Jiangsu Kanion Pharmaceutical Company Limited, Lianyungang 222001, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Li
authors.forename: Yuling
authors.initials: Y
authors.lastname: Xu
authors.forename: Juan
authors.initials: J
authors.lastname: Song
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Yingzhi
authors.initials: Y
authors.lastname: Pan
authors.forename: Zhengzhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D004731:Endotoxins / Q000302:isolation & purification*; D007267:Injections; D011749:Pyrogens / Q000302:isolation & purification*; D014462:Ultrafiltration
chemical_list: D004731:Endotoxins; D011749:Pyrogens