title: Mortality trends in asbestosis, extrinsic allergic alveolitis and sarcoidosis in England and Wales.
abstract: BACKGROUND
  To ascertain the trends in mortality from Asbestosis, Extrinsic Allergic Alveolitis (EAA) and Sarcoidosis in England and Wales, we analysed mortality data from the Office of National Statistics.
  
  
  METHODS
  We calculated age and stratum specific mortality rates between 1968 and 2008 and applied these to the 2008 population to generate annual standardised expected number of deaths. Poisson regression was used to calculate annual mortality rate ratios.
  
  
  RESULTS
  From 1968 to 2008 there were 1958 registered deaths from Asbestosis, 878 deaths from EAA and 3544 deaths from Sarcoidosis. The Asbestosis mortality rate increased from 0.04 (95% CI 0.03-0.05) in the 1968-1972 calendar period to 0.12 (95% CI 0.10-0.13) in the 2005-2008 period whist the mortality from EAA increased marginally from 0.04 (95% CI 0.03-0.05) in the 1968-1972 calendar period to 0.08 (95% CI 0.07-0.09) in the 2005-2008 period. Mortality from Sarcoidosis increased by approximately 9% a year.
  
  
  CONCLUSIONS
  Our findings show that the mortality from Asbestosis continues to rise in the UK. Overall mortality rates from EAA remained stable throughout the same period but it was higher in males and in older people. There was a slight increase in mortality from Sarcoidosis over the study period which was greater in women.
authors.affiliation: Division of Epidemiology and Public Health, University of Nottingham, Nottingham NG5 1PB, UK.
authors.forename: A
authors.initials: A
authors.lastname: Hanley
authors.forename: R B
authors.initials: RB
authors.lastname: Hubbard
authors.forename: V
authors.initials: V
authors.lastname: Navaratnam
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000542:Alveolitis, Extrinsic Allergic / Q000401:mortality*; D001195:Asbestosis / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D003644:Death Certificates; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D009784:Occupational Diseases / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D017565:Sarcoidosis, Pulmonary / Q000401:mortality*; D017678:Sex Distribution; D014852:Wales / Q000453:epidemiology; D055815:Young Adult