title: [Correlation between cardiovascular risk factors and the expression of cardiovascular disease related genes in cynomolgus monkeys].
abstract: The correlation between cardiovascular risk factors and cardiovascular disease related genes plays an important role in early-warning risk and early diagnosis. Thirty middle-aged male crab-eating macaques were fed a moderately atherogenic diet (0.053 mg cholesterol/kJ and 40% of calories as saturated fat) for twelve months. According to cardiovascular risk factors, we selected low-risk and high-risk crab-eating macaques, then analyzed the expression of 113 cardiovascular related genes by real-time PCR. A total of 65 genes were detected in peripheral blood leukocytes by real-time PCR. Sixteen up-regulated genes and nineteen down-regulated genes were detected in low-risk and high-risk crab-eating macaques compared to normal crab-eating macaques (P<0.05), in addition to fifteen genes that showed unique expression patterns (P<0.05). We also detected 42 genes in human peripheral blood leukocytes. The expression patterns of 22 genes were consistent between human and crab-eating macaques. These results narrowed the scope of genes for further research.
authors.affiliation: Guangdong Entomological Institute, Guangzhou 510260, China.
authors.forename: Ji-Liang
authors.initials: JL
authors.lastname: Xia
authors.forename: Xiang-Fen
authors.initials: XF
authors.lastname: Hao
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zeng
authors.forename: Li-Sha
authors.initials: LS
authors.lastname: Jin
authors.forename: Tong
authors.initials: T
authors.lastname: Zhou
authors.forename: Xue-Jia
authors.initials: XJ
authors.lastname: Li
authors.forename: Yun-Xiao
authors.initials: YX
authors.lastname: Sun
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Rao
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Liu
authors.forename: Bai-Lu
authors.initials: BL
authors.lastname: Peng
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000009:adverse effects / Q000378:metabolism; D004032:Diet / Q000009:adverse effects; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D008252:Macaca fascicularis / Q000235:genetics / Q000378:metabolism; D008297:Male; D012307:Risk Factors
chemical_list: D002791:Cholesterol, Dietary