title: Multi-institutional prostate cancer study of genetic susceptibility in populations of African descent.
abstract: Prostate cancer disparities have been reported in men of African descent who show the highest incidence, mortality, compared with other ethnic groups. Few studies have explored the genetic and environmental factors for prostate cancer in men of African ancestry. The glutathione-S-transferases family conjugates carcinogens before their excretion and is expressed in prostate tissue. This study addressed the role of GSTM1 and GSTT1 deletions on prostate cancer risk in populations of African descent. This multi-institutional case-control study gathered data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database, the African-Caribbean Cancer Consortium (AC3) and Men of African Descent and Carcinoma of the Prostate Consortium (MADCaP). The analysis included 10 studies (1715 cases and 2363 controls), five in African-Americans, three in African-Caribbean and two in African men. Both the GSTM1 and the GSTT1 deletions showed significant inverse associations with prostate cancer [odds ratio (OR): 0.90, 95% confidence interval (CI) 0.83-0.97 and OR 0.88, 95% CI: 0.82-0.96, respectively]. The association was restricted to Caribbean and African populations. A significant positive association was observed between GSTM1 deletion and prostate cancer in smokers in African-American studies (OR: 1.28, 95% CI: 1.01-1.56), whereas a reduced risk was observed in never-smokers (OR: 0.66, 95% CI: 0.46-0.95). The risk of prostate cancer increased across quartiles of pack-years among subjects carrying the deletion of GSTM1 but not among subjects carrying a functional GSTM1. Gene-environment interaction between smoking and GSTM1 may be involved in the etiology of prostate cancer in populations of African descent.
authors.affiliation: Institute of Translational Epidemiology, Mount Sinai School of Medicine, New York, NY, USA. taiolema@gmail.com
authors.forename: Emanuela
authors.initials: E
authors.lastname: Taioli
authors.forename: Rafael E
authors.initials: RE
authors.lastname: Flores-Obando
authors.forename: Ilir
authors.initials: I
authors.lastname: Agalliu
authors.forename: Pascal
authors.initials: P
authors.lastname: Blanchet
authors.forename: Clareann H
authors.initials: CH
authors.lastname: Bunker
authors.forename: Robert E
authors.initials: RE
authors.lastname: Ferrell
authors.forename: Maria
authors.initials: M
authors.lastname: Jackson
authors.forename: La Creis R
authors.initials: LC
authors.lastname: Kidd
authors.forename: Suzanne
authors.initials: S
authors.lastname: Kolb
authors.forename: Nicol A
authors.initials: NA
authors.lastname: Lavender
authors.forename: Norma
authors.initials: N
authors.lastname: McFarlane-Anderson
authors.forename: Seian S
authors.initials: SS
authors.lastname: Morrison
authors.forename: Luc
authors.initials: L
authors.lastname: Multigner
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Ostrande
authors.forename: Jong Y
authors.initials: JY
authors.lastname: Park
authors.forename: Alan L
authors.initials: AL
authors.lastname: Patrick
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Rebbeck
authors.forename: Marc
authors.initials: M
authors.lastname: Romana
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stanford
authors.forename: Flora
authors.initials: F
authors.lastname: Ukoli
authors.forename: Tiva T
authors.initials: TT
authors.lastname: Vancleave
authors.forename: Charnita M
authors.initials: CM
authors.lastname: Zeigler-Johnson
authors.forename: Batsirai
authors.initials: B
authors.lastname: Mutetwa
authors.forename: Camille
authors.initials: C
authors.lastname: Ragin
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000368:Aged; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000209:etiology / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1