title: Assessment of risk to humans of bisphenol A in marine and freshwater fish from Pearl River Delta, China.
abstract: Bisphenol A (BPA) is a high production-volume chemical used in the manufacture of a wide variety of consumer products. However it is also a ubiquitous contaminant that can interfere with endocrine systems of wildlife and humans. China is the "world factory" and the Pearl River Delta is the major manufacturing center and is consequently polluted. Concentrations of BPA in meats of marketable fish had not been previously reported for this region. In the study upon which we report here concentrations of BPA were determined in 20 common species of freshwater and marine fish, collected from markets in Hong Kong, SAR, China. A comprehensive analytical method based on SPE extraction and liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) was developed, validated and applied. The method limit of detection (LOD) and limit of quantification (LOQ) were 0.5 and 1.25 ng g(-1) dw, respectively. BPA was detected in 19 species of fish at concentrations, ranging from 0.5 to 2.0 ng g(-1) ww. Average daily BPA intake per person ranged from 1.1×10(2) ng d(-1) for marine fish and 2.2×10(2) ng d(-1) for freshwater fish. Concentrations of BPA in fish from Hong Kong markets unlikely would be causing adverse population-level effects in humans.
authors.affiliation: Department of Biology, Croucher Institute of Environmental Sciences, Hong Kong Baptist University, Hong Kong, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Wei
authors.forename: Yeqing
authors.initials: Y
authors.lastname: Huang
authors.forename: Ming H
authors.initials: MH
authors.lastname: Wong
authors.forename: John P
authors.initials: JP
authors.lastname: Giesy
authors.forename: Chris K C
authors.initials: CK
authors.lastname: Wong
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D002681:China; D004968:Estrogens, Non-Steroidal / Q000032:analysis*; D005399:Fishes / Q000378:metabolism; D005506:Food Contamination / Q000032:analysis*; D006723:Hong Kong; D006801:Humans; D057230:Limit of Detection; D010636:Phenols / Q000032:analysis*; D045483:Rivers / Q000737:chemistry*; D017747:Seafood / Q000032:analysis*; D052616:Solid Phase Extraction / Q000379:methods; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods; D014874:Water Pollutants, Chemical / Q000032:analysis; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D014874:Water Pollutants, Chemical; C006780:bisphenol A; D000098826:Bisphenol A Compounds