title: Long-term follow-up of children with 6-thioguanine-related chronic hepatoxicity following treatment for acute lymphoblastic leukaemia.
abstract: 6-Thioguanine (6-TG) therapy in childhood acute lymphoblastic leukaemia results in chronic hepatotoxicity and portal hypertension. We report follow-up data in a cohort of 10 children with acute lymphoblastic leukaemia and 6-TG-related hepatotoxicity described initially in 2006. Clinically significant portal hypertension was present in the majority of patients several years after cessation of 6-TG treatment. These data reflect the natural history of noncirrhotic portal hypertension and emphasises the need to incorporate ongoing surveillance in the transition arrangement to adult services in this select group of patients.
authors.affiliation: Department of Hepatology, Birmingham Children's Hospital, Birmingham, UK.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Rawat
authors.forename: Peter M
authors.initials: PM
authors.lastname: Gillett
authors.forename: David
authors.initials: D
authors.lastname: Devadason
authors.forename: David C
authors.initials: DC
authors.lastname: Wilson
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: McKiernan
mesh_terms: D000293:Adolescent; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000473:pathology*; D002648:Child; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006975:Hypertension, Portal / Q000139:chemically induced / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D013866:Thioguanine / Q000008:administration & dosage* / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D013866:Thioguanine