title: Comparison of single-dose and multiple-dose antibiotics for lower urinary tract infection in pregnancy.
abstract: OBJECTIVE
  To compare the efficacy of fosfomycin trometamol, cefuroxime axetil, and amoxicillin clavulanate antibiotics, and to assess the difference in patient compliance, in the treatment of urinary tract infections during pregnancy.
  
  
  METHODS
  Between September 2007 and May 2008, 90 out of 324 pregnant women with complaints of lower urinary tract infection, who were followed at the outpatient clinic or referred to the emergency department of Vakif Gureba Education and Research Hospital, were enrolled in a prospective study. Patients were randomized into 3 equal groups for treatment with single-dose fosfomycin trometamol, or 5-day courses of amoxicillin clavulanate or cefuroxime axetil. After follow-up, study data were obtained for 28, 27, and 29 patients, respectively.
  
  
  RESULTS
  The treatment groups did not differ significantly in terms of demographics, clinical success rate, microbiological cure rate, or adverse effects. Significantly higher drug compliance was observed in the fosfomycin trometamol group than in the other 2 groups (P<0.05).
  
  
  CONCLUSIONS
  Treatment with a single dose of fosfomycin trometamol was as effective for UTI as the standard course of treatment with amoxicillin clavulanate or cefuroxime axetil. Fosfomycin trometamol may be a preferable treatment for UTI because of its simpler use and better rates of compliance.
authors.affiliation: Department of Obstetrics and Gynecology, Bagcilar Education and Research Hospital, Istanbul, Turkey. tanerusta74@yahoo.com
authors.forename: Taner A
authors.initials: TA
authors.lastname: Usta
authors.forename: Ozgur
authors.initials: O
authors.lastname: Dogan
authors.forename: Ugur
authors.initials: U
authors.lastname: Ates
authors.forename: Burak
authors.initials: B
authors.lastname: Yucel
authors.forename: Zehra
authors.initials: Z
authors.lastname: Onar
authors.forename: Erdal
authors.initials: E
authors.lastname: Kaya
mesh_terms: D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002444:Cefuroxime / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage; D006801:Humans; D010349:Patient Compliance / Q000706:statistics & numerical data; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D019980:Amoxicillin-Potassium Clavulanate Combination; D002444:Cefuroxime; C040738:cefuroxime axetil