title: Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts using Ruppert-Prakash reagent.
abstract: The organocatalyzed regioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts using Ruppert-Prakash reagent was achieved in high to excellent yields via a successive S(N)2'/S(N)2' mode for the first time. The reaction was extended to the asymmetric allylic trifluoromethylation by the use of a bis-cinchona alkaloid catalyst with high enantioselectivities up to 94% ee.
authors.affiliation: Department of Frontier Materials, Nagoya Institute of Technology, Gokiso, Nagoya, 466-8555, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Furukawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nishimine
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tokunaga
authors.forename: Kimiko
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Norio
authors.initials: N
authors.lastname: Shibata