title: Therapeutic vaccination with an EGF-based vaccine in lung cancer: a step in the transition to a chronic disease.
abstract: The trend of increased survival in advanced tumors suggests the possibility of the transformation of cancer into a chronic disease. That goal will require therapeutic weapons with low toxicity that can be used chronically. Here we summarize the development of a therapeutic vaccine consisting in recombinant EGF chemically linked to a protein from Neisseria meningitides. In mice, the vaccine elicited antibodies to self-EGF and had anti-tumor activity. Clinical trials have shown that the vaccine is also immunogenic and well tolerated in humans. The vaccination produced a decrease in plasma EGF concentration. Advanced lung cancer patients eliciting high antibody titers of EGF had better survival. The vaccine can be used long term and integrated with other treatment modalities.
authors.affiliation: Center of Molecular Immunology, Atabey, Playa, Havana 11600, Cuba.
authors.forename: Gryssell
authors.initials: G
authors.lastname: Rodriguez
authors.forename: Gisela
authors.initials: G
authors.lastname: Gonzalez
authors.forename: Tania
authors.initials: T
authors.lastname: Crombet
authors.forename: Agustin
authors.initials: A
authors.lastname: Lage
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood; D001425:Bacterial Outer Membrane Proteins / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D019496:Cancer Vaccines / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D004815:Epidermal Growth Factor / Q000009:adverse effects / Q000097:blood / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D009345:Neisseria meningitidis / Q000276:immunology*; D016896:Treatment Outcome; D014614:Vaccines, Synthetic / Q000627:therapeutic use
chemical_list: D001323:Autoantibodies; D001425:Bacterial Outer Membrane Proteins; D019496:Cancer Vaccines; D014614:Vaccines, Synthetic; C112623:lpdA protein, Neisseria meningitidis; D004815:Epidermal Growth Factor