title: Henoch Schönlein purpura associated with pulmonary adenocarcinoma.
abstract: BACKGROUND
  Henoch-Schönlein purpura is a common immunoglobulin A-mediated vasculitis syndrome in children. Henoch-Schönlein purpura can also affect adults and is probably related to malignancy.
  
  
  METHODS
  We report the case of a 61-year-old Japanese man who presented for examination after an abnormal shadow was detected by chest radiography. He received a diagnosis of pulmonary adenocarcinoma, stage IV. Purpura on the legs, abdominal pain, diarrhea, hematuria and proteinuria developed at this time. Henoch-Schönlein purpura was diagnosed, base on the clinical symptoms and histological findings of biopsy specimens of the skin, which showed vasculitis with immunoglobulin A deposits. Our patient received chemotherapy with gemcitabine after successful steroid therapy for the Henoch-Schönlein purpura.
  
  
  CONCLUSIONS
  Although hematological malignancies are well-known causes of vasculitides, cases of Henoch-Schönlein purpura associated with lung adenocarcinoma are rare. Our patient was treated with corticosteroid therapy, which cleared the purpura and cytotoxic chemotherapy for the non-small cell lung cancer. However, he died from heart failure due to cardiac tamponade.
authors.affiliation: Department of Medicine (II), Niigata University Medical and Dental Hospital, 951-8520 Niigata, Japan. satoshimd@yahoo.co.jp.
authors.forename: Daiki
authors.initials: D
authors.lastname: Mifune
authors.forename: Satoshi
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authors.lastname: Watanabe
authors.forename: Rie
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authors.lastname: Kondo
authors.forename: Yoko
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authors.lastname: Wada
authors.forename: Hiroshi
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authors.lastname: Moriyama
authors.forename: Hiroshi
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authors.lastname: Kagamu
authors.forename: Hirohisa
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authors.lastname: Yoshizawa
authors.forename: Takafumi
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authors.lastname: Tetsuka
authors.forename: Asako
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authors.lastname: Matsuyama
authors.forename: Kaoru
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authors.lastname: Ito
authors.forename: Ichiei
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authors.lastname: Narita