title: Detection of two HLA-A alleles, A*31:30 and A*26:20, in two Taiwanese volunteer bone marrow donors by sequence-based typing.
abstract: We here report detection of a novel sequence of HLA-A*31:30 and a confirmatory sequence of HLA*26:20 from two Taiwanese individuals. The sequence of A*31:30 is identical to that of A*31:01:02 in exons 2 and 3, except one nucleotide (n.t.) substitution c.539T > G resulting in p.Leu180Trp. The sequence of A*26:20 is identical to A*26:01:01 in exons 2 and 3, except a segment of the sequence from n.t. 78 to n.t.102. The mismatched sequence segment is identical to a sequence segment of A*02:03:01, suggesting that the formation of A*26:20 was resulted from a DNA recombination event between A*26:01:01 and A*02:03:01 sequences. A*26:20 differs from A*26:01:01 with c.98A > T resulting in p.Tyr33Phe.
authors.affiliation: Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank and Buddhist Tzu Chi Marrow Donor Registry, Buddhist Tzu Chi Stem Cells Centre, Buddhist Tzu Chi General Hospital, Buddhist Compassion Relief Tzu Chi Foundation, Hualien, Taiwan. edward@tzuchi.com.tw
authors.forename: K L
authors.initials: KL
authors.lastname: Yang
authors.forename: S K
authors.initials: SK
authors.lastname: Lee
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: S
authors.initials: S
authors.lastname: Jiang
authors.forename: H M
authors.initials: HM
authors.lastname: Chiu
authors.forename: S
authors.initials: S
authors.lastname: Lin
authors.forename: Y C
authors.initials: YC
authors.lastname: Chen
authors.forename: S P
authors.initials: SP
authors.lastname: Chen
authors.forename: S Y
authors.initials: SY
authors.lastname: Yang
authors.forename: Y F
authors.initials: YF
authors.lastname: Jian
authors.forename: M H
authors.initials: MH
authors.lastname: Shyr
authors.forename: C L
authors.initials: CL
authors.lastname: Lin
authors.forename: P Y
authors.initials: PY
authors.lastname: Lin
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001483:Base Sequence; D001853:Bone Marrow / Q000276:immunology*; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D013624:Taiwan
chemical_list: D015234:HLA-A Antigens