title: Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes.
abstract: Transfusion-dependent myelodysplastic (MDS) patients are prone to iron overload. We evaluated 43 transfused MDS patients with T2* magnetic resonance imaging scans. 81% had liver and 16·8% cardiac iron overload. Liver R2* (1000/T2*), but not cardiac R2*, was correlated with number of units transfused (r=0·72, P<0·0001) and ferritin (r=0·53, P<0·0001). The area under the curve of a time-ferritin plot was found to be much greater in patients with cardiac iron loading (median 53·7x10(5) Megaunits vs. 12·2x10(5) Megaunits, P=0·002). HFE, HFE2, HAMP or SLC40A1 genotypes were not predictors of iron overload in these patients.
authors.affiliation: Molecular Haematology Unit, Weatherall Institute of Molecular Medicine Department of Cardiology, Oxford, UK. noemi@romahi.com
authors.forename: Noémi B A
authors.initials: NB
authors.lastname: Roy
authors.forename: Saul
authors.initials: S
authors.lastname: Myerson
authors.forename: Anna H
authors.initials: AH
authors.lastname: Schuh
authors.forename: Patricia
authors.initials: P
authors.lastname: Bignell
authors.forename: Roger
authors.initials: R
authors.lastname: Patel
authors.forename: Jim S
authors.initials: JS
authors.lastname: Wainscoat
authors.forename: Simon
authors.initials: S
authors.lastname: McGowan
authors.forename: Emanuele
authors.initials: E
authors.lastname: Marchi
authors.forename: Wale
authors.initials: W
authors.lastname: Atoyebi
authors.forename: Tim
authors.initials: T
authors.lastname: Littlewood
authors.forename: Joseph
authors.initials: J
authors.lastname: Chacko
authors.forename: Paresh
authors.initials: P
authors.lastname: Vyas
authors.forename: Sally B
authors.initials: SB
authors.lastname: Killick
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D019190:Iron Overload / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000628:therapy*; D009206:Myocardium / Q000378:metabolism*; D012189:Retrospective Studies; D065227:Transfusion Reaction
chemical_list: D015415:Biomarkers; D005293:Ferritins