title: Comprehensive analysis of TGF-β and BMP receptor interactomes.
abstract: An immense number of cellular processes are initiated by cell surface serine/threonine kinase receptors belonging to the TGF-β/BMP family. Subsequent downstream signalling cascades, as well as their crosstalk results in enormous specificity in terms of phenotypic outcome, e.g. proliferation, differentiation, migration or apoptosis. Such signalling diversity is achieved by the ability of receptors to interact with distinct proteins in a spatio-temporal manner. Following the cloning of the TGF-β/BMP receptors a variety of different technologies were applied to identify such interacting proteins. Here we present a comprehensive survey of known interactome analyses, including our own data, on these receptors and discuss advantages and disadvantages of the applied technologies.
authors.affiliation: Institute for Chemistry and Biochemistry, Freie Universität Berlin, Thielallee 63, 14195 Berlin, Germany.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Poorgholi Belverdi
authors.forename: Carola
authors.initials: C
authors.lastname: Krause
authors.forename: Asja
authors.initials: A
authors.lastname: Guzman
authors.forename: Petra
authors.initials: P
authors.lastname: Knaus
mesh_terms: D000818:Animals; D052004:Bone Morphogenetic Protein Receptors / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D054730:Protein Interaction Domains and Motifs / Q000502:physiology*; D040901:Proteomics / Q000379:methods*; D016212:Transforming Growth Factor beta / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology
chemical_list: D016212:Transforming Growth Factor beta; D052004:Bone Morphogenetic Protein Receptors