title: [Immunohistochemical study of human fetal vomerona structures the nasal septum, by applying neuron-specific beta3-tubulin antibodies].
abstract: The functioning of Jacobson's or vomeronasal organ (VNO) in man is the subject-matter of discussion today. It is generally taken that VNO as an anatomic structure also remains in the adult; however, its receptor apparatus still degenerates in the fetal stage of ontogenesis. Nevertheless, the data available in the literature on the time and specific features of degenerative changes in the human fetal VNO are conflicting and ambiguous. The authors examined the human fetal nasal septum from the 8th week of development to birth, by applying the traditional histological procedures and neuron-specific beta3-tubulin antibodies. An immunohistochemical study could first show the receptor apparatus of the human fetal VNO at weeks 8-26 of development. The immunohistochemical study on a series of sections could reveal the regularities of spatial receptor distribution depending on the time of fetal development. In addition, the developed human fetal vomeronasal nerve and ganglion at weeks 8-26 were described, in human fetuses at weeks 8-26. The neuron-specific marker test has shown the nerve fibers departing directly from the VNO wall, which is inconsistent with the data available in the literature on vomeronasal nerve degeneration in this sign just after the 18th week of development.
authors.forename: A S
authors.initials: AS
authors.lastname: Kharlamova
authors.forename: V M
authors.initials: VM
authors.lastname: Barabanov
authors.forename: S V
authors.initials: SV
authors.lastname: Savel'ev
mesh_terms: D000906:Antibodies; D015415:Biomarkers / Q000032:analysis; D005260:Female; D005333:Fetus; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009300:Nasal Septum / Q000033:anatomy & histology* / Q000196:embryology* / Q000294:innervation; D009474:Neurons / Q000276:immunology; D014404:Tubulin / Q000032:analysis / Q000276:immunology; D019147:Vomeronasal Organ / Q000033:anatomy & histology* / Q000196:embryology* / Q000294:innervation
chemical_list: D000906:Antibodies; D015415:Biomarkers; D014404:Tubulin