title: Adriamycin-related anxiety-like behavior, brain oxidative stress and myelotoxicity in male Wistar rats.
abstract: Chemotherapeutic regimens have been indicated to negatively impact the quality of life for patients. Adriamycin (ADR) is an effective chemotherapeutic agent widely employed for the treatment of human's malignancies; however, it may cause serious side effects. The present study was aimed at investigating the effects of acute administration of ADR on cognitive alterations, brain oxidative status and immune dysregulation in male Wistar rats. Treated animals received a single intraperitoneal injection of ADR (7 mg/kg). Control ones received physiological saline only. Behavioral effects were tested in the elevated plus-maze and the open field which showed that drug-treated rats displayed anxious behavior and deteriorations in the locomotive and exploratory activities over the 72 h following ADR injection as compared to controls. Assessment of brain antioxidant capacity in ADR-injected animals revealed an increase in glutathione-S-transferase activities and malondialdehyde levels while a decrease in glutathione concentrations when compared with the vehicle-treated group. Our results indicated that ADR administration decreased total leukocyte, lymphocyte and granulocyte counts, while enhanced monocyte levels. Moreover, white blood cells (WBC) relative counts in ADR-treated rats showed a significant increase in monocytes and granulocytes and a decrease in lymphocytes as compared to controls. This study suggests that ADR-related cognitive impairments are associated with brain oxidative stress and myelosuppression.
authors.affiliation: Laboratoire de Neuro-endocrinologie Appliquée, Département de Biologie, Université Badji Mokhtar, BP 12, 23000, Annaba, Algeria. merzougs@yahoo.fr
authors.forename: Sameha
authors.initials: S
authors.lastname: Merzoug
authors.forename: Mohamed Lamine
authors.initials: ML
authors.lastname: Toumi
authors.forename: Nadia
authors.initials: N
authors.lastname: Boukhris
authors.forename: Bruno
authors.initials: B
authors.lastname: Baudin
authors.forename: Abdelkrim
authors.initials: A
authors.lastname: Tahraoui
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology*; D001772:Blood Cell Count; D001853:Bone Marrow / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D004317:Doxorubicin / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D009419:Nerve Tissue Proteins; D004317:Doxorubicin; D005982:Glutathione Transferase; D005978:Glutathione