title: Tamoxifen/norfloxacin interaction leading to QT interval prolongation in a female patient with extracranial meningioma.
abstract: The authors report on a case of tamoxifen/norfloxacin interaction leading to QT interval prolongation in an 83-year-old female patient with extracranial meningioma treated with radiation and hormonal therapy (with Tamoxifen). This case report highlights the potential risk of tamoxifen causing depression of electrical impulse in sinoatrial node, leading to symptomatic sinus bradycardia with prolonged QT interval. At the same time it indicates the need to be on the look out for drug interactions (in our case between tamoxifen and norfloxacin), as well as to be aware of other drugs possibly inducing QT interval prolongation (Fig. 2, Ref. 7).
authors.affiliation: Clinical Oncology and Radiation Therapy Department, Charles University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic. ladislav.slovacek@seznam.cz
authors.forename: L
authors.initials: L
authors.lastname: Slovacek
authors.forename: P
authors.initials: P
authors.lastname: Priester
authors.forename: J
authors.initials: J
authors.lastname: Petera
authors.forename: I
authors.initials: I
authors.lastname: Slanska
authors.forename: J
authors.initials: J
authors.lastname: Kopecky
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D008577:Meningeal Neoplasms / Q000188:drug therapy*; D008579:Meningioma / Q000188:drug therapy*; D009643:Norfloxacin / Q000009:adverse effects*; D013125:Spinal Neoplasms / Q000188:drug therapy*; D013629:Tamoxifen / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen; D009643:Norfloxacin