title: Probable interaction between trazodone and carbamazepine.
abstract: The need to maintain long-term treatment of chronic pathologies makes the appearance of interactions possible when such therapies incorporate other drugs to deal with the aggravation of the same or other intercurrent pathologies. A case is presented in which the addition of trazodone to a chronic treatment with carbamazepine (CBZ) is associated with symptoms typical for intoxication by this antiepileptic, accompanied by a raised serum concentration. When the trazodone was suspended, these symptoms lessened and the concentration of CBZ decreased progressively, suggesting a probable interaction between the 2 drugs.
authors.forename: A
authors.initials: A
authors.lastname: Sánchez-Romero
authors.forename: A
authors.initials: A
authors.lastname: Mayordomo-Aranda
authors.forename: R
authors.initials: R
authors.lastname: García-Delgado
authors.forename: J A
authors.initials: JA
authors.lastname: Durán-Quintana
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000097:blood / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D018692:Antimanic Agents / Q000097:blood / Q000627:therapeutic use*; D002220:Carbamazepine / Q000097:blood / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D004347:Drug Interactions; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D006801:Humans; D014196:Trazodone / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D018687:Antidepressive Agents, Second-Generation; D018692:Antimanic Agents; D002220:Carbamazepine; D014196:Trazodone