title: Unprecedented incorporation of α-emitter radioisotope 213Bi into porphyrin chelates with reference to a daughter isotope mediated assistance mechanism.
abstract: For the first time, α-emitter radioisotope (213)Bi has been incorporated into porphyrin chelates, with rates matching with the short period of the radionuclide. An in situ transmetalation mechanism involving the daughter isotope (209)Pb is expected to boost the (213)Bi radiolabeling process.
authors.affiliation: Sciences Chimiques de Rennes, University of Rennes1, UMR CNRS 6226, 263 av. du Général Leclerc, CS 74205, 35042 Rennes Cedex, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Le Gac
authors.forename: Btissam
authors.initials: B
authors.lastname: Najjari
authors.forename: Nicolas
authors.initials: N
authors.lastname: Motreff
authors.forename: Patricia
authors.initials: P
authors.lastname: Remaud-Le Saec
authors.forename: Alain
authors.initials: A
authors.lastname: Faivre-Chauvet
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Dimanche-Boitrel
authors.forename: Alfred
authors.initials: A
authors.lastname: Morgenstern
authors.forename: Frank
authors.initials: F
authors.lastname: Bruchertseifer
authors.forename: Mohammed
authors.initials: M
authors.lastname: Lachkar
authors.forename: Bernard
authors.initials: B
authors.lastname: Boitrel
mesh_terms: D000512:Alpha Particles; D001729:Bismuth / Q000737:chemistry*; D045744:Cell Line, Tumor; D002614:Chelating Agents / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry / Q000633:toxicity; D018360:Crystallography, X-Ray; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007856:Lead Radioisotopes / Q000737:chemistry; D008968:Molecular Conformation; D011166:Porphyrins / Q000737:chemistry*; D011868:Radioisotopes / Q000737:chemistry
chemical_list: D002614:Chelating Agents; D056831:Coordination Complexes; D007856:Lead Radioisotopes; D011166:Porphyrins; D011868:Radioisotopes; D001729:Bismuth