title: Thiolated mucoadhesive and PEGylated nonmucoadhesive organosilica nanoparticles from 3-mercaptopropyltrimethoxysilane.
abstract: A novel approach has been developed to synthesize thiolated sub-100 nm organosilica nanoparticles from 3-mercaptopropyltrimethoxysilane (MPTS) through its self-condensation in dimethylsulfoxide in contact with atmospheric oxygen. The formation of MPTS nanoparticles proceeds through the condensation of methoxysilane groups and simultaneous disulfide bridging caused by partial oxidation of thiol groups. These nanoparticles showed excellent colloidal stability in dilute aqueous dispersions but underwent further self-assembly into chains and necklaces at higher concentrations. They exhibited very good ability to adhere to ocular mucosal surfaces, which can find applications in drug delivery. The thiolated nanoparticles could also be easily modified through PEGylation resulting in a loss of their mucoadhesive properties.
authors.affiliation: Reading School of Pharmacy, University of Reading, Whiteknights, RG6 6AD Reading, United Kingdom.
authors.forename: Galiya S
authors.initials: GS
authors.lastname: Irmukhametova
authors.forename: Grigoriy A
authors.initials: GA
authors.lastname: Mun
authors.forename: Vitaliy V
authors.initials: VV
authors.lastname: Khutoryanskiy
mesh_terms: D003102:Colloids / Q000737:chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D003102:Colloids; D017646:Organosilicon Compounds; D012821:Silanes; D013438:Sulfhydryl Compounds; D011092:Polyethylene Glycols; C102833:(3-mercaptopropyl)trimethoxysilane