title: The influence of individual bone patterns on peri-implant bone loss: preliminary report from a 3-year randomized clinical and histologic trial in patients treated with implants restored with matching-diameter abutments or the platform-switching concept.
abstract: OBJECTIVE
  This study sought to determine whether there was a correlation between bone resorption and individual bone patterns in patients treated with implants restored conventionally or using the platform-switching concept.
  
  
  METHODS
  Ten patients (24 implants) were randomly assigned to receive implants with different platform diameters (3.8, 4.3, 4.8, or 5.5 mm), all of which were restored with standard 3.8-mm-diameter abutments. Biopsy specimens were obtained prior to implant placement, and histologic and immunohistochemical analyses were performed. Standardized radiographs were made at each site after implant placement and at 36 months after prosthetic loading and bone levels were determined.
  
  
  RESULTS
  One patient dropped out, resulting in a total of 9 patients and 22 implants. Mean bone resorption was 1.358 mm for non-platform-switched implants; mean resorption was 0.832, 0.486, and 0.375 mm for implant platforms of 4.3, 4.8, and 5.5 mm, respectively. After standardization of peri-implant bone remodeling values, a borderline direct correlation between peri-implant bone changes and levels of biglycans was found. At the same time, a borderline indirect correlation between bone changes and levels of tumor necrosis factor-a was found.
  
  
  CONCLUSIONS
  Within the limit of this study, which was conducted in a small patient sample over a short observation period, an individual resorption trend was detected and paralleled by immunohistochemical findings. Individual local bone structure and quality seemed to be correlated to peri-implant bone resorption. Correlations between biglycan and tumor necrosis factor-a and bone resorption should be confirmed by a larger patient sample.
authors.affiliation: University of Bonn, Germany. luigicanullo@yahoo.com
authors.forename: Luigi
authors.initials: L
authors.lastname: Canullo
authors.forename: Giuliano
authors.initials: G
authors.lastname: Iannello
authors.forename: Werner
authors.initials: W
authors.lastname: Götz
mesh_terms: D000368:Aged; D016301:Alveolar Bone Loss / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D058578:Biglycan / Q000378:metabolism; D016723:Bone Remodeling; D000044:Dental Abutments / Q000009:adverse effects; D003758:Dental Implantation, Endosseous / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D015921:Dental Implants / Q000009:adverse effects*; D017267:Dental Prosthesis Design; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007576:Jaw, Edentulous, Partially / Q000534:rehabilitation / Q000601:surgery; D008137:Longitudinal Studies; D008297:Male; D008334:Mandible / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D016348:Osseointegration; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D058578:Biglycan; D015921:Dental Implants; D014409:Tumor Necrosis Factor-alpha