title: Immunogenicity of inactivated polio vaccine with concurrent antiviral V-073 administration in mice.
abstract: Immunization of mice with inactivated polio vaccine (IPV) with concurrent dosing of poliovirus antiviral V-073 showed no detrimental impact on the elicitation of serum-neutralizing antibodies. A strategy involving coadministration of antiviral V-073 and IPV can be considered for the management of poliovirus incidents.
authors.affiliation: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Kouiavskaia
authors.forename: Marc S
authors.initials: MS
authors.lastname: Collett
authors.forename: Eugenia M
authors.initials: EM
authors.lastname: Dragunsky
authors.forename: Andrey
authors.initials: A
authors.lastname: Sarafanov
authors.forename: Konstantin M
authors.initials: KM
authors.lastname: Chumakov
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D000998:Antiviral Agents / Q000008:administration & dosage*; D051379:Mice; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D000998:Antiviral Agents; D011054:Poliovirus Vaccine, Inactivated