title: Association between cholesteryl ester transfer protein TaqIB variants and risk of coronary artery disease and diabetes mellitus in the population of western Iran.
abstract: OBJECTIVE
  To shed light on the previously inconsistent results about the association of cholesteryl ester transfer protein TaqIB (CETP TaqIB) variants, high-density lipoprotein cholesterol (HDL-C) levels, and the risk of coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  To determine the frequency of CETP TaqIB variants and to examine the possible association between CETP TaqIB polymorphism with CAD and T2DM, we studied 207 unrelated patients with CAD, 101 patients with T2DM, and 92 controls. The CETP TaqIB variants were detected by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  Logistic regression analysis indicated that the B1 allele of CETP was significantly associated with increased risk of CAD (odds ratio, OR 1.65 [95% confidence interval, CI 1.2-2.3, p=0.005]) and T2DM (OR 1.7 [95% CI 1.13-2.54, p=0.005]). Adjusted logistic regression analysis for the effects of age, sex, hypertension, diabetes, and hyperlipidemia was performed; and a significant association was found between the B1 allele and risk of CAD (OR 1.9 [95% CI 1-3.6, p=0.049]) in patients with CAD. There were no associations between the CETP alleles and the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, and HDL-C in studied groups.
  
  
  CONCLUSIONS
  The results of the present study revealed that the CETP B1 allele is associated with increased risk of CAD and T2DM independent of plasma HDL-C level in our population.
authors.affiliation: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. zrahimi@kums.ac.ir
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Rahimi
authors.forename: Reza
authors.initials: R
authors.lastname: Nourozi-Rad
authors.forename: Asad
authors.initials: A
authors.lastname: Vaisi-Raygani
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Saidi
authors.forename: Ziba
authors.initials: Z
authors.lastname: Rahimi
authors.forename: Reza
authors.initials: R
authors.lastname: Ahmadi
authors.forename: Reza
authors.initials: R
authors.lastname: Yarani
authors.forename: Koorosh
authors.initials: K
authors.lastname: Hamzehee
authors.forename: Abbas
authors.initials: A
authors.lastname: Parsian
mesh_terms: D000368:Aged; D000483:Alleles; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics* / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D048909:Diabetes Complications / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL