title: Comparison of coronal and axial computed tomography measurements of mediastinal nodes before primary surgery for non-small cell lung cancer.
abstract: OBJECTIVE
  To assess computed tomography (CT) evaluation of mediastinal nodes in non-small cell lung cancer to predict metastatic involvement by measurement of their axis and surface area in the coronal plane, as compared to standard short-axis measures in the axial plane.
  
  
  METHODS
  Evaluation of mediastinal nodes was retrospectively performed on CT scans of 100 patients before thoracotomy. In all patients, mediastinal dissection was performed in the appropriate stations (n=264) according to the side (59 right, 41 left) of the tumor. Measurements of short axis and surface area of the largest node in each dissected station were performed on axial and coronal planes.
  
  
  RESULTS
  By using the standard threshold of axial short axis ≥10 mm, sensitivity and specificity were 25% and 98%, respectively. Areas under receiver operating characteristic curves were 0.828 and 0.821 for axial short axis and axial surface area data. For comparison, areas under receiver operating characteristic curves were 0.843 and 0.845 for coronal short axis and coronal surface area data, respectively. So, for a specificity of 98%, sensitivity was 29% for coronal short axis ≥11 mm and 33% for coronal surface area ≥123 mm(2). When using axial short axis ≥10 mm or coronal surface area ≥120 mm(2), sensitivity was 45%, whereas specificity remained at 96%.
  
  
  CONCLUSIONS
  Coronal measurements of mediastinal nodes give a slightly albeit non-significant improvement of diagnostic accuracy over axial ones. If both axial short axis and coronal surface area are taken into account, accuracy is improved.
authors.affiliation: Department of Radiology, Hôtel Dieu Hospital, AP-HP, 1, Place du Parvis Notre-Dame, 75181 Paris Cedex, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Guinet
authors.forename: Pascal
authors.initials: P
authors.lastname: Rousset
authors.forename: Antonio
authors.initials: A
authors.lastname: Bobbio
authors.forename: Marco
authors.initials: M
authors.lastname: Alifano
authors.forename: Diane
authors.initials: D
authors.lastname: Damotte
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Régnard
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Buy
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging* / Q000601:surgery; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*