title: Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery.
abstract: Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated.
authors.affiliation: Department of Gastrointestinal and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands. p.l.jansen@amc.uva.nl
authors.forename: Peter L M
authors.initials: PL
authors.lastname: Jansen
authors.forename: Jochem
authors.initials: J
authors.lastname: van Werven
authors.forename: Edo
authors.initials: E
authors.lastname: Aarts
authors.forename: Frits
authors.initials: F
authors.lastname: Berends
authors.forename: Ignace
authors.initials: I
authors.lastname: Janssen
authors.forename: Jaap
authors.initials: J
authors.lastname: Stoker
authors.forename: Frank G
authors.initials: FG
authors.lastname: Schaap
mesh_terms: D001647:Bile Acids and Salts / Q000097:blood; D005346:Fibroblast Growth Factors / Q000097:blood*; D015390:Gastric Bypass; D006801:Humans; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery
chemical_list: D001647:Bile Acids and Salts; C117476:FGF19 protein, human; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors