title: Surface immobilizable chelator for label-free electrical detection of pyrophosphate.
abstract: A new pyrophosphate (PPi) chelator was designed for surface-sensitive electrical detection of biomolecular reactions. This article describes the synthesis of the PPi-selective receptor, its surface immobilization and application to label-free electrical detection on a silicon-based field-effect transistor (FET) sensor.
authors.affiliation: Integrated Biosystems Lab, Intel Labs, Intel Corporation, 2200 Mission College Blvd., Santa Clara, CA 95054, USA. djqliu@gmail.com
authors.forename: David J
authors.initials: DJ
authors.lastname: Liu
authors.forename: Grace M
authors.initials: GM
authors.lastname: Credo
authors.forename: Xing
authors.initials: X
authors.lastname: Su
authors.forename: Kai
authors.initials: K
authors.lastname: Wu
authors.forename: Hsiao C
authors.initials: HC
authors.lastname: Lim
authors.forename: Oguz H
authors.initials: OH
authors.lastname: Elibol
authors.forename: Rashid
authors.initials: R
authors.lastname: Bashir
authors.forename: Madoo
authors.initials: M
authors.lastname: Varma
mesh_terms: D002396:Catechols / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry*; D011756:Diphosphates / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry; D012825:Silicon / Q000737:chemistry; D013499:Surface Properties; D014173:Transistors, Electronic
chemical_list: D002396:Catechols; D002614:Chelating Agents; D011756:Diphosphates; D005456:Fluorescent Dyes; C034221:catechol; D012825:Silicon