title: Activation of the immune system and sperm DNA fragmentation are associated with idiopathic oligoasthenoteratospermia in men with couple subfertility.
abstract: Ejaculates from men without known causes for male subfertility and asymptomatic for genital tract inflammation showed infiltration of macrophages, and their activation state (HLA-DR(+)) was negatively correlated with semen parameters and positively correlated with sperm DNA damage. An activation of the immune system is thus detectable in idiopathic oligoasthenoteratozoospermia of unknown origin.
authors.affiliation: Andrology Unit, Department of Internal Medicine, University of l'Aquila, l'Aquila, Italy.
authors.forename: Fiore
authors.initials: F
authors.lastname: Pelliccione
authors.forename: Anatolia
authors.initials: A
authors.lastname: d'Angeli
authors.forename: Benedetta
authors.initials: B
authors.lastname: Cinque
authors.forename: Stefano
authors.initials: S
authors.lastname: Falone
authors.forename: Alessandro
authors.initials: A
authors.lastname: Micillo
authors.forename: Felice
authors.initials: F
authors.lastname: Francavilla
authors.forename: Fernanda
authors.initials: F
authors.lastname: Amicarelli
authors.forename: Loredana
authors.initials: L
authors.lastname: Gandini
authors.forename: Sandro
authors.initials: S
authors.lastname: Francavilla
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D053938:DNA Fragmentation; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007248:Infertility, Male / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D007558:Italy; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012661:Semen / Q000166:cytology / Q000276:immunology; D013094:Spermatozoa / Q000473:pathology*
chemical_list: D006684:HLA-DR Antigens