title: Association between Takayasu arteritis and ulcerative colitis - case report and review of serological HLA analysis.
abstract: BACKGROUND
  Takayasu arteritis and ulcerative colitis are immune-mediated inflammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported.
  
  
  METHODS
  In this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Takayasu arteritis. He was found to carry the following human leukocyte antigens (HLA): A11, A24, B52, B62, DR4, and DR9.
  
  
  CONCLUSIONS
  We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases. In patients with both Takayasu arteritis and ulcerative colitis, high frequency of HLA-A24, B52, and DR 2 is observed. The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.
authors.affiliation: 4th Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo City, Shimane, Japan. yukihiro@med.shimane-u.ac.jp
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Tanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugamori
authors.forename: Masatake
authors.initials: M
authors.lastname: Sato
authors.forename: Jun
authors.initials: J
authors.lastname: Kitamura
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Sato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshitomi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Toshio
authors.initials: T
authors.lastname: Shimada
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications / Q000235:genetics* / Q000473:pathology; D004452:Echocardiography; D004562:Electrocardiography; D055106:Genome-Wide Association Study; D015234:HLA-A Antigens / Q000097:blood*; D059871:HLA-A24 Antigen; D015235:HLA-B Antigens / Q000097:blood*; D059950:HLA-B52 Antigen; D015802:HLA-DR2 Antigen / Q000097:blood*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007564:Japan; D018810:Magnetic Resonance Angiography; D008297:Male; D012698:Serologic Tests / Q000379:methods; D013625:Takayasu Arteritis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D015234:HLA-A Antigens; D059871:HLA-A24 Antigen; D015235:HLA-B Antigens; D059950:HLA-B52 Antigen; D015802:HLA-DR2 Antigen