title: Human carbonic anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor.
abstract: d(6)-piano-stool complexes bearing an arylsulfonamide anchor display sub-micromolar affinity towards human Carbonic Anhydrase II (hCA II). The 1.3 Å resolution X-ray crystal structure of [(η(6)-C(6)Me(6))Ru(bispy 3)Cl](+)⊂ hCA II highlights the nature of the host-guest interactions.
authors.affiliation: Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland.
authors.forename: Fabien W
authors.initials: FW
authors.lastname: Monnard
authors.forename: Tillmann
authors.initials: T
authors.lastname: Heinisch
authors.forename: Elisa S
authors.initials: ES
authors.lastname: Nogueira
authors.forename: Tilman
authors.initials: T
authors.lastname: Schirmer
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Ward
mesh_terms: D024402:Carbonic Anhydrase II / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry; D018360:Crystallography, X-Ray; D006801:Humans; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D012428:Ruthenium / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D013449:Sulfonamides; D012428:Ruthenium; D024402:Carbonic Anhydrase II