title: Polysaccharide protein complex isolated from mushroom Phellinus rimosus (berk.) Pilat alleviates γ radiation-induced toxicity in mice.
abstract: Ionizing radiations generate reactive oxygen species in irradiated tissue that induces several pathophysiological changes in the body. Radiotherapy induced toxicity is a major dose-limiting factor in anticancer treatments. Radioprotective agents are of significant importance in medical, industrial, environmental, military, and space applications. Radioprotective effect of polysaccharide protein complex (PPC-Pr) isolated from mushroom, Phellinus rimosus, was evaluated in Swiss albino mice. PPC-Pr (5 and 10 mg/kg bwt, i.p.) significantly increased leukocyte count, bone marrow cellularity, glutathione content, and activities of antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase in blood as well as intestinal mucosa when compared with the irradiated control group. Histopathological observation of intestinal jejunal mucosa revealed the tissue protective effects of PPC-Pr. Further radioprotective activity of PPC-Pr was in a dose-dependent manner. The findings suggest potential radioprotective efficacy of PPC-Pr.
authors.affiliation: Department of Microbiology, Amala Cancer Research Centre, Thrissur, Kerala, India.
authors.forename: Jini
authors.initials: J
authors.lastname: Joseph
authors.forename: Thozhuthum Parambil Pathmanabhan
authors.initials: TP
authors.lastname: Smina
authors.forename: Kainoor Krishnankutty
authors.initials: KK
authors.lastname: Janardhanan
mesh_terms: D000363:Agaricales / Q000378:metabolism / Q000528:radiation effects*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001853:Bone Marrow / Q000528:radiation effects; D002374:Catalase / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D005979:Glutathione Peroxidase / Q000378:metabolism; D007413:Intestinal Mucosa / Q000201:enzymology / Q000473:pathology; D007962:Leukocytes / Q000166:cytology; D008297:Male; D051379:Mice; D011134:Polysaccharides / Q000378:metabolism* / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D011134:Polysaccharides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase