title: An unusual presentation of invasive squamous cell carcinoma of the upper extremities in a patient with a history of severe electrical burns and chronic thermal and chemical exposure.
abstract: This is a case report that depicts an atypical presentation of very aggressive, metachronous invasive squamous cell carcinomas of the upper extremities in a patient with no prior history of precancerous or cancerous skin lesions and no significant solar radiation exposure. Potentially causative factors that played a role in the emergence of this aggressive form of skin cancer in this case study are multifactorial: (1) chronic thermal exposure of 3000 degrees F daily to his hands for an eight to ten-year time period; (2) chronic chemical exposure of DMSO solvent and higher levels of chemical contaminants such and finally; (3) a form of chronic immunosuppression as a result of his severe electrical burns that resulted in widespread second and third burns throughout his body.
authors.affiliation: University of Pennsylvania, USA.
authors.forename: Brian L
authors.initials: BL
authors.lastname: Chang
authors.forename: Alyssa
authors.initials: A
authors.lastname: Chang
authors.forename: Jon
authors.initials: J
authors.lastname: Strasser
authors.forename: John F
authors.initials: JF
authors.lastname: Reinhardt
authors.forename: Michael
authors.initials: M
authors.lastname: Guarino
mesh_terms: D002058:Burns, Electric / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D004121:Dimethyl Sulfoxide; D006225:Hand; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D012997:Solvents
chemical_list: D012997:Solvents; D004121:Dimethyl Sulfoxide