title: Fetal protection against bovine viral diarrhoea type 1 virus infection after one administration of a live-attenuated vaccine.
abstract: A modified-live vaccine has been shown previously to prevent fetal infection with bovine viral diarrhoea virus (BVDV)-2 and, to some extent BVDV-1, when used in association with an inactivated vaccine in a two-step vaccination protocol. In this challenge study, the modified-live vaccine used alone was able to protect 13 heifers between 49 and 96 days of gestation at challenge from leucopenia and virus replication and, for a 4-month period, to prevent fetal infection. The efficacy of the BVDV-1f 22146/Han81 challenge was demonstrated by virus isolation from the fetuses of all nine non-vaccinated, control heifers. However, the small number of heifers tested meant that the vaccination failure rate could be as high as 10% in the field.
authors.affiliation: INRA, UMR1225, IHAP, F-31076 Toulouse, France. g.meyer@envt.fr
authors.forename: Gilles
authors.initials: G
authors.lastname: Meyer
authors.forename: Martine
authors.initials: M
authors.lastname: Deplanche
authors.forename: Dominique
authors.initials: D
authors.lastname: Roux
authors.forename: Martine
authors.initials: M
authors.lastname: Moulignie
authors.forename: Nicole
authors.initials: N
authors.lastname: Picard-Hagen
authors.forename: Faouzi
authors.initials: F
authors.lastname: Lyazrhi
authors.forename: Didier
authors.initials: D
authors.lastname: Raboisson
authors.forename: Pierre
authors.initials: P
authors.lastname: Mathevet
authors.forename: François
authors.initials: F
authors.lastname: Schelcher
mesh_terms: D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000517:prevention & control* / Q000635:transmission; D002417:Cattle; D030241:Diarrhea Virus 1, Bovine Viral / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005315:Fetal Diseases / Q000517:prevention & control / Q000662:veterinary*; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control / Q000662:veterinary*; D011247:Pregnancy; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines