title: Heparan sulfate proteoglycans.
abstract: Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and coreceptors. Although few in number, heparan sulfate proteoglycans have profound effects at the cellular, tissue, and organismal level.
authors.affiliation: Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California 92093, USA.
authors.forename: Stephane
authors.initials: S
authors.lastname: Sarrazin
authors.forename: William C
authors.initials: WC
authors.lastname: Lamanna
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Esko
mesh_terms: D002448:Cell Adhesion; D002454:Cell Differentiation; D002465:Cell Movement; D018925:Chemokines / Q000378:metabolism; D004705:Endocytosis; D005109:Extracellular Matrix / Q000378:metabolism; D019812:Heparan Sulfate Proteoglycans / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008024:Ligands; D008954:Models, Biological; D009154:Mutation; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology; D013379:Substrate Specificity
chemical_list: D018925:Chemokines; D019812:Heparan Sulfate Proteoglycans; D008024:Ligands; D011956:Receptors, Cell Surface