title: Differential acute toxicity of tetrachlorobenzene isomers to oligochaetes in soil and water: application of the critical body residue concept.
abstract: The acute, lethal potency of the 1,2,3,4-, 1,2,4,5- and 1,2,3,5-tetrachlorobenzene isomers was compared in the terrestrial and aquatic oligochaetes Eisenia andrei and Tubifex tubifex. 1,2,4,5-TeCB was neither lethal, nor produced any perceptible adverse effects, at lipid normalized concentrations predicted to be lethal according to the well-established critical body residue concept. If a narcotic is defined as a substance capable of inducing narcosis, rather than a substance displaying certain physical or chemical properties (e.g., log K(ow)), then we do not believe these findings challenge the critical body residue because by the former definition, 1,2,4,5-tetrachlorobenzene is not a narcotic.
authors.affiliation: Environmental Science Graduate Program, The Ohio State University, Columbus, 43210, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Hurdzan
authors.forename: Roman P
authors.initials: RP
authors.lastname: Lanno
authors.forename: David M
authors.initials: DM
authors.lastname: Sovic
mesh_terms: D000818:Animals; D002722:Chlorobenzenes / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D007536:Isomerism; D007928:Lethal Dose 50; D009835:Oligochaeta / Q000187:drug effects* / Q000378:metabolism; D012989:Soil Pollutants / Q000737:chemistry / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity*
chemical_list: D002722:Chlorobenzenes; D012989:Soil Pollutants; D014874:Water Pollutants, Chemical; C018673:1,2,4,5-tetrachlorobenzene; C030387:1,2,3,5-tetrachlorobenzene; C030386:1,2,3,4-tetrachlorobenzene