title: The impact of adding an extra dimension to a preference-based measure.
abstract: The ability to compare incremental changes in Quality Adjusted Life Years (QALYs) generated by different condition-specific preference-based measures (CSPBMs), or indeed between generic measures, is often criticised even where the valuation methods and source of values are the same. A key concern is the impact of excluding key dimensions from a descriptive system. This study examines the impact of adding a generic pain/discomfort dimension to a CSPBM, the AQL-5D (an asthma-specific CSPBM), by valuing samples of states from the AQL-5D with and without the new dimension using an interviewer administered time trade-off with a sample of the U.K. general public. 180 respondents provided 720 valuations for states with and without pain/discomfort. As expected the additional pain/discomfort dimension was found to have a significant and relatively large coefficient. More importantly for comparing changes in QALYs across populations the addition of pain/discomfort significantly impacts on the coefficients of the other dimensions and the degree of impact differs by dimension and severity level. The net effect on the utility value depends on the severity of their state: the addition of pain/discomfort at level 1 (no pain/discomfort) or 2 (moderate pain/discomfort) significantly increased the mean health state values in an asthma patient population; whereas level 3 pain/discomfort (extreme) reduced values. Comparability between measures requires that the impact of different dimensions on preferences is additive, whether or not they are included in the classification system. Our results cast doubt on this assumption, implying that the chosen measure must contain all important and relevant dimensions in its classification system.
authors.affiliation: University of Sheffield, UK. j.e.brazier@sheffield.ac.uk
authors.forename: John
authors.initials: J
authors.lastname: Brazier
authors.forename: Donna
authors.initials: D
authors.lastname: Rowen
authors.forename: Aki
authors.initials: A
authors.lastname: Tsuchiya
authors.forename: Yaling
authors.initials: Y
authors.lastname: Yang
authors.forename: Tracy A
authors.initials: TA
authors.lastname: Young
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001249:Asthma / Q000191:economics / Q000523:psychology*; D016009:Chi-Square Distribution; D003625:Data Collection; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D010146:Pain; D010147:Pain Measurement; D017060:Patient Satisfaction; D011594:Psychometrics; D019057:Quality-Adjusted Life Years; D012044:Regression Analysis; D012720:Severity of Illness Index; D055815:Young Adult