title: Histamine blood concentration in ischemic heart disease patients.
abstract: The aim of this study was to investigate histamine blood concentration in subjects suffering from different types of ischemic heart diseases during the period of eight days. Our results showed that the histamine blood level was associated with different types of ischemic heart diseases. The blood histamine level in all investigated patients was significantly higher when compared to control subjects (44.87 ± 1.09 ng mL(-1)), indicating the increase of histamine release in patients suffering from coronary diseases. In patients suffering from ACS-UA and ACS-STEMI, the second day peak of histamine level occurs (90.85 ± 6.34 ng mL(-1) and 121.7 ± 6.34 ng mL(-1), resp.) probably as the reperfusion event. Furthermore, our data suggest that histamine can be additional parameter of myocardial ischemia along with cardiac specific enzymes and may prove to be an excellent single prognostic marker for multitude of ischemic heart diseases.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Zdravkovic
authors.forename: Suzana
authors.initials: S
authors.lastname: Pantovic
authors.forename: Gvozden
authors.initials: G
authors.lastname: Rosic
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Tomic-Lucic
authors.forename: Nemanja
authors.initials: N
authors.lastname: Zdravkovic
authors.forename: Maja
authors.initials: M
authors.lastname: Colic
authors.forename: Zdravko
authors.initials: Z
authors.lastname: Obradovic
authors.forename: Mirko
authors.initials: M
authors.lastname: Rosic
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D054059:Coronary Occlusion / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis*; D019210:Troponin I / Q000097:blood
chemical_list: D019210:Troponin I; D006632:Histamine