title: Penile gangrene due to calcific uremic arteriopathy.
abstract: Calcific uremic arteriopathy (CUA) is a rare but potentially life-threatening complication of end-stage renal disease (ESRD) and secondary hyperparathyroidism. It typically presents with ischemic necrosis involving areas of adiposity in the body mainly the trunk, buttocks, or proximal extremity. Patients can also present with digital ischemia and more rarely penile gangrene. The pathogenesis of CUA is not yet clear but several putative factors, mainly hyperparathyroidism and related metabolic abnormalities are implicated. A number of conditions can mimic CUA clinically and should be differentiated from it. We present in the current study, a patient who presented with progressive penile gangrene and skin necrosis due to CUA. We review the current understanding of the pathogenesis, diagnosis/differential diagnosis, and management of this rare but potentially life-threatening complication of ESRD.
authors.affiliation: Department of Medicine, Bayero University, Kano, Nigeria. bappakano@yahoo.com
authors.forename: Adamu
authors.initials: A
authors.lastname: Bappa
authors.forename: Fayaz
authors.initials: F
authors.lastname: Hakim
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ahmad
authors.forename: Abdullahi
authors.initials: A
authors.lastname: Assirri
mesh_terms: D000368:Aged; D001158:Arteries / Q000473:pathology; D002115:Calciphylaxis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D005734:Gangrene / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D010409:Penile Diseases / Q000209:etiology* / Q000473:pathology; D010413:Penis / Q000098:blood supply / Q000473:pathology; D016312:Treatment Refusal; D014511:Uremia / Q000150:complications* / Q000175:diagnosis / Q000628:therapy