title: [Systemic lupus erythematosus].
abstract: Systemic lupus erythematosus (SLE) is the classical systemic autoimmune disease. Its prevalence is slightly below 1:1,000 in women and 10-fold lower in men. Typically, the disease manifests in women of childbearing age. While severe untreated SLE used to be a fatal disease, prognosis has improved stepwise with corticosteroids, cyclophosphamide and novel therapies. Deaths directly related to SLE are uncommon nowadays but infections, thromboses and accelerated atherosclerosis cause significant problems. The current review presents the state of the art in managing SLE patients.
authors.affiliation: Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland. martin.aringer@uniklinikum-dresden.de
authors.forename: M
authors.initials: M
authors.lastname: Aringer
authors.forename: F
authors.initials: F
authors.lastname: Hiepe
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000367:Age Factors; D000962:Antimalarials / Q000009:adverse effects / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D003430:Cross-Sectional Studies; D003520:Cyclophosphamide / Q000627:therapeutic use; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use; D015438:Health Behavior; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008019:Life Style; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D008297:Male; D011379:Prognosis; D012737:Sex Factors; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D000305:Adrenal Cortex Hormones; D000962:Antimalarials; D001323:Autoantibodies; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide