title: Elevated adipose triglyceride lipase in newly diagnosed type 2 diabetes mellitus with hypertension.
abstract: BACKGROUND
  Adipose triglyceride lipase (ATGL) is a recently identified triacylglycerol lipase responsible for adiposity lipolysis. Its pathophysiologic role in humans remains unknown.
  
  
  METHODS
  In this study, the authors investigated the levels of plasma ATGL among patients with type 2 diabetes mellitus (T2DM), patients with T2DM and hypertension and control subjects. They also assessed the association between plasma ATGL and body composition and metabolic parameters.
  
  
  CONCLUSIONS
  Plasma ATGL levels significantly increased in patients with T2DM and hypertension compared with those with T2DM (78.3 ± 23.4 versus 65.1 ± 22.8 μg/L, P < 0.01). No gender differences were found among plasma ATGL levels. Furthermore, they found that the plasma ATGL level was positively correlated with total cholesterol (r = 0.17, P < 0.05) and high-density lipoprotein C (r = 0.16, P < 0.05) in simple regression analysis of pooled data, whereas, in multiple stepwise regression analysis, diastolic blood pressure, total cholesterol and homeostasis model assessment of insulin resistance were independently related factors with plasma ATGL levels (Y = -13.662 + 0.343 × waist + 0.268 × diastolic blood pressure + 0.053 × 2hPin + 0.966 × homeostasis model assessment of insulin resistance). This work indicates the potential link of ATGL with the pathogenesis of insulin resistance and T2DM.
authors.affiliation: Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education, Chongqing Medical University, China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Xu
authors.forename: Gangyi
authors.initials: G
authors.lastname: Yang
authors.forename: Mengliu
authors.initials: M
authors.lastname: Yang
authors.forename: Shengbing
authors.initials: S
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001823:Body Composition; D015992:Body Mass Index; D002681:China; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D054467:Phospholipases A2 / Q000097:blood*; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose; D008075:Lipoproteins, HDL; D002784:Cholesterol; D054467:Phospholipases A2