title: SPIO-RGD nanoparticles as a molecular targeting probe for imaging tumor angiogenesis using synchrotron radiation.
abstract: Angiogenesis, new blood vessels sprouting from pre-existing vessels, is essential to tumor growth, invasion and metastasis. It can be used as a biomarker for early stage tumor diagnosis and targeted therapy. To visualize angiogenesis many molecular imaging modalities have been used. In this study a novel X-ray molecular targeting probe using superparamagnetic iron oxide (SPIO) conjugated with arginine-glycine-aspartic acid (SPIO-RGD) has been developed. Based on the extremely high sensitivity to the iron element of synchrotron radiation X-ray fluorescence and the superior spatial resolution of third-generation synchrotron radiation, the feasibility of SPIO-RGD as a promising molecular probe for imaging tumor angiogenesis has been demonstrated.
authors.affiliation: Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Chunfu
authors.initials: C
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Lisa X
authors.initials: LX
authors.lastname: Xu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D015335:Molecular Probes; D053758:Nanoparticles; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic; D009842:Oligopeptides / Q000737:chemistry*; D017356:Synchrotrons
chemical_list: D015335:Molecular Probes; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid