title: Collagen meniscus implantation: a systematic review including rehabilitation and return to sports activity.
abstract: OBJECTIVE
  To determine collagen meniscus implant (CMI) efficacy for improving patient function, symptoms, and activity level. Study methodologies, rehabilitation, and return to sports guidelines were also reviewed.
  
  
  METHODS
  MedLine, EMBASE, CINAHL, Life Science Citations, and Cochrane Central Register of Controlled Trials databases were searched from January 1995-May 2011 using the term collagen meniscal or meniscus implant. Only human studies with English language abstracts that reported patient outcomes were included. Modified Coleman Methodology criteria were used to score research quality.
  
  
  RESULTS
  Eleven studies with 520 subjects (men = 428; women = 92; 17.7% women) of 38.2 ± 3.7 years of age met the inclusion criteria. Of these subjects, 321 (men = 263, women = 58; 18.1% women) received a CMI. Based primarily on Lysholm Knee Score, Tegner Activity Scale, pain scales and self-assessment measurements knee function, symptoms, and activity level generally improved by 46.6 ± 39.9 months post-surgery. Rehabilitation was described in 9/11 (81.8%) studies and four released patients to full activities at 6 months post-surgery. No study described how advanced rehabilitation or function testing contributed to return to activity decision-making. Research quality was generally low (67.1 ± 18.6) with widely ranging (29-97) scores. Reduced CMI size at last follow-up was reported in 6/11 (54.5%) studies, but the significance of this finding is unknown.
  
  
  CONCLUSIONS
  Knee function, symptoms, and activity level generally improved following CMI use, but poor research report quality was common. Additional well-designed long-term prospective studies are needed to better determine knee osteoarthrosis prevention efficacy and appropriate patient selection.
authors.affiliation: Division of Sports Medicine, Department of Orthopaedic Surgery, University of Louisville, 210 East Gray Street, Suite 1003, Louisville, KY 40202, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Harston
authors.forename: John
authors.initials: J
authors.lastname: Nyland
authors.forename: Emily
authors.initials: E
authors.lastname: Brand
authors.forename: Mark
authors.initials: M
authors.lastname: McGinnis
authors.forename: David N M
authors.initials: DN
authors.lastname: Caborn
mesh_terms: D001178:Arthroplasty / Q000295:instrumentation / Q000379:methods*; D001265:Athletic Injuries / Q000601:surgery*; D024042:Collagen Type I; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D008592:Menisci, Tibial / Q000601:surgery*; D017410:Practice Guidelines as Topic; D020127:Recovery of Function; D013526:Surgical Mesh; D000070600:Tibial Meniscus Injuries; D016896:Treatment Outcome
chemical_list: D024042:Collagen Type I