title: Oral choline supplementation in children with intestinal failure.
abstract: Choline deficiency leads to steatohepatitis, elevated transaminases, susceptibility to septic shock, and an increased risk of central catheter thrombosis. Children with intestinal failure (IF) are at risk for choline deficiency. In an unblinded, open-label study, we studied 7 children with IF on parenteral nutrition, measured their plasma free choline level, and, if low, supplemented enterally with adequate intake (AI) doses of choline. Four to 6 weeks later we remeasured their plasma free choline. Unlike adults, infants did not respond to oral choline supplementation at AI doses. Additionally, we have calculated plasma free choline percentiles versus age for normal children.
authors.affiliation: Division of Pediatric Gastroenterology and Nutrition, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. aguerrerio@jhmi.edu
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Guerrerio
authors.forename: Lynn
authors.initials: L
authors.lastname: Mattis
authors.forename: Kim G
authors.initials: KG
authors.lastname: Conner
authors.forename: Jenifer
authors.initials: J
authors.lastname: Hampsey
authors.forename: D Mikis
authors.initials: DM
authors.lastname: Stasinopoulos
authors.forename: Robert
authors.initials: R
authors.lastname: DeJong
authors.forename: Emad M
authors.initials: EM
authors.lastname: Boctor
authors.forename: Shelia
authors.initials: S
authors.lastname: Sheth
authors.forename: Ulrike M
authors.initials: UM
authors.lastname: Hamper
authors.forename: Ann O
authors.initials: AO
authors.lastname: Scheimann
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000367:Age Factors; D002648:Child; D002794:Choline / Q000097:blood / Q000627:therapeutic use*; D002796:Choline Deficiency / Q000209:etiology / Q000517:prevention & control; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D007422:Intestines / Q000503:physiopathology*; D008297:Male; D010288:Parenteral Nutrition; D010865:Pilot Projects; D012778:Short Bowel Syndrome / Q000097:blood / Q000178:diet therapy / Q000503:physiopathology
chemical_list: D002794:Choline