title: Predicting crystalline lens fall caused by accommodation from changes in wavefront error.
abstract: OBJECTIVE
  To illustrate and develop a method for estimating crystalline lens decentration as a function of accommodative response using changes in wavefront error and show the method and limitations using previously published data (2004) from 2 iridectomized monkey eyes so that clinicians understand how spherical aberration can induce coma, in particular in intraocular lens surgery.
  
  
  METHODS
  College of Optometry, University of Houston, Houston, USA.
  
  
  METHODS
  Evaluation of diagnostic test or technology.
  
  
  METHODS
  Lens decentration was estimated by displacing downward the wavefront error of the lens with respect to the limiting aperture (7.0 mm) and ocular first surface wavefront error for each accommodative response (0.00 to 11.00 diopters) until measured values of vertical coma matched previously published experimental data (2007). Lens decentration was also calculated using an approximation formula that only included spherical aberration and vertical coma.
  
  
  RESULTS
  The change in calculated vertical coma was consistent with downward lens decentration. Calculated downward lens decentration peaked at approximately 0.48 mm of vertical decentration in the right eye and approximately 0.31 mm of decentration in the left eye using all Zernike modes through the 7th radial order. Calculated lens decentration using only coma and spherical aberration formulas was peaked at approximately 0.45 mm in the right eye and approximately 0.23 mm in the left eye.
  
  
  CONCLUSIONS
  Lens fall as a function of accommodation was quantified noninvasively using changes in vertical coma driven principally by the accommodation-induced changes in spherical aberration. The newly developed method was valid for a large pupil only.
  
  
  BACKGROUND
  Neither author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: Visual Optics Institute, College of Optometry, University of Houston, Houston, Texas, USA. lhe.2011@alumni.opt.uh.edu
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Raymond A
authors.initials: RA
authors.lastname: Applegate
mesh_terms: D000065:Accommodation, Ocular / Q000502:physiology*; D019781:Corneal Topography; D057108:Corneal Wavefront Aberration / Q000503:physiopathology; D006801:Humans; D007908:Lens, Crystalline / Q000503:physiopathology*; D008962:Models, Theoretical; D011680:Pupil / Q000502:physiology; D012030:Refractive Errors / Q000503:physiopathology*