title: Cerebral hypermetabolism demonstrated by FDG PET in familial Creutzfeldt-Jakob disease.
abstract: Right cerebral and contralateral cerebellar hypermetabolism were observed on FDG PET in a 68-year-old woman with familial Creutzfeldt-Jakob disease (CJD) at an early stage before seizures occurred. The disease progressed with frequent seizures, myoclonus, and a startle reaction. In all past reports, FDG PET studies demonstrated hypometabolism in the cerebrum, cerebellum, and thalamus in patients with CJD. Focal hypermetabolism corresponding with epileptic foci is a common finding in ictal epilepsy patients, and hypometabolism is common in patients with myoclonus or the startle reaction. This finding may reflect a prodromal pathophysiology of epilepsy. Attention should be paid to the diagnosis of CJD while using FDG PET.
authors.affiliation: Department of Neurology, University of Yamanashi, Chuo-shi, Yamanashi, Japan. nagat@yamanshi.ac.jp
authors.forename: Takamura
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Kaori
authors.initials: K
authors.lastname: Nagasaka
authors.forename: Emiko
authors.initials: E
authors.lastname: Ohta
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Shindo
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takiyama
authors.forename: Zenji
authors.initials: Z
authors.lastname: Shiozawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyazawa
authors.forename: Naomi
authors.initials: N
authors.lastname: Yamasaki
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Mori
authors.forename: Hideaki
authors.initials: H
authors.lastname: Onda
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Shinohara
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D007562:Creutzfeldt-Jakob Syndrome / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18