title: Cananginones A–I, linear acetogenins from the stem bark of Miliusa velutina [corrected].
abstract: Nine linear C23 and C21 acetogenins, named cananginones A-I (1-9), were isolated from stem bark of Miliusa velutina [corrected] . Their structures were established by spectroscopic methods. These compounds showed cytotoxicity against three cancer cell lines (KB, MCF7 and NCI-H187) with IC₅₀ values in the range 16.6-129.7 μM. Only 5 showed weak antimalarial activity against Plasmodium falciparum. In addition, 8 and 9 exhibited weak antifungal activity against Candida albicans.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Nikhom
authors.initials: N
authors.lastname: Wongsa
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
mesh_terms: D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D054362:Cananga / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D054378:Acetogenins; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts