title: [Changes of serum lipids after soy isoflavone and calcium supplementation in postmenopausal Chinese women with different ER-beta genotypes].
abstract: OBJECTIVE
  To observe the change of blood lipids after one-year of soy isoflavone and calcium supplementation in postmenopausal Chinese women with different ER-beta genotypes.
  
  
  METHODS
  Sixty postmenopausal women with normal serum lipid levels but with bone loss or even osteoporosis were selected from Wuhan. The ER-beta genotypes of subjects were identified. The subjects were randomly divided into two groups, group I was given 440 mg/d calcium and VD 100 IU/d and group II was given calcium 440 mg/d, VD 100 IU/d and soy isoflavone 100mg/d for one year. Serum lipids, including TG, CHO, LDL and HDL were measured before and 12 months after intervention.
  
  
  RESULTS
  Total cholesterol was decreased both in group I and group II (P <0. 05). The change of serum TG was significantly different between group I and group II in subjects with Rr/rr genotype (0. 20 +/- 0. 41 and 0. 44 +/- 0. 93, P <0. 05).
  
  
  CONCLUSIONS
  Rational intervention with calcium and soy isoflavone for postmenopausal women might be in favor of their health in bone and blood lipids metabolism, but the effects might be varied by different ER-beta genotypes.
authors.affiliation: Institute of Nutrition and Food Safety, China CDC, Beijing 100050, China. zhenwuhuang@sina.com
authors.forename: Zhenwu
authors.initials: Z
authors.lastname: Huang
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Gong
mesh_terms: D044466:Asian People; D002118:Calcium / Q000008:administration & dosage*; D019587:Dietary Supplements; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage* / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects / Q000378:metabolism*; D013025:Glycine max / Q000737:chemistry
chemical_list: D047629:Estrogen Receptor beta; D007529:Isoflavones; D008055:Lipids; D002118:Calcium