title: Genetic polymorphism of IGF-I predicts recurrence in patients with gastric cancer who have undergone curative gastrectomy.
abstract: BACKGROUND
  To our knowledge, no reports have evaluated the effects of genetic polymorphisms of insulin-like growth factor-I (IGF-I) on clinical outcomes of gastric cancer patients.
  
  
  METHODS
  We retrospectively analyzed the impact of IGF-I polymorphisms on recurrence-free survival (RFS) in 430 patients with gastric cancer who underwent curative gastrectomy between 2001 and 2005 in our institution.
  
  
  RESULTS
  Among the 430 gastric cancer patients, 345 were pathological stage I or II, while 85 were stage III or IV. The median 5-year RFS rate was 85.3% (95% confidence interval [CI] 81.4-88.5). In a multivariate Cox model (adjusted for age, gender, histology, pathological stage, adjuvant chemotherapy, and history of diabetes), two IGF-I polymorphisms, rs1520220 and rs2195239, were significantly associated with RFS (hazard ratio [HR] 0.60, 95% CI 0.40-0.91; and HR 0.60, 95% CI 0.41-0.89, respectively, in a per-allele model). When stratified by stage (I-II versus III-IV), rs1520220 in particular was associated with RFS in patients with stage III-IV disease, with a P-value for interaction of 0.01.
  
  
  CONCLUSIONS
  Our findings indicate that genetic polymorphisms of IGF-I may have a substantial effect on recurrence for gastric cancer patients who have undergone curative gastrectomy. This information may help identify population subgroups that could benefit from IGF-I-targeting agents.
authors.affiliation: Departments of Clinical Oncology.
authors.forename: K
authors.initials: K
authors.lastname: Shitara
authors.affiliation: Departments of Surgery, Aichi Cancer Center Hospital, Nagoya.
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.affiliation: Departments of Surgery, Aichi Cancer Center Hospital, Nagoya.
authors.forename: K
authors.initials: K
authors.lastname: Misawa
authors.affiliation: Departments of Surgery, Aichi Cancer Center Hospital, Nagoya.
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya.
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya.
authors.forename: S
authors.initials: S
authors.lastname: Hosono
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya.
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Director, Aichi Cancer Center Research Institute, Nagoya.
authors.forename: K
authors.initials: K
authors.lastname: Tajima
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya; Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Departments of Clinical Oncology.
authors.forename: K
authors.initials: K
authors.lastname: Muro
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya; Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: kmatsuo@aichi-cc.jp.
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D005743:Gastrectomy; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery
chemical_list: D007334:Insulin-Like Growth Factor I