title: The reliability of maternal serum triple test in prenatal diagnosis of fetal chromosomal abnormalities of pregnant Turkish women.
abstract: OBJECTIVE
  The purpose of this article was to evaluate the reliability of maternal serum triple marker screening of alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol for the prenatal diagnosis of fetal chromosomal abnormalities in Turkish pregnant women.
  
  
  METHODS
  Medical records were used to analyze indications of amniocentesis and quantitative fluorescent-polymerase chain reaction. Anomaly screening was performed for all patients between 13 and 22 weeks of pregnancy. A total of 1725 pregnancies with chromosomal abnormality risk according to triple test screening were accepted for fetal chromosome analysis and quantitative fluorescent-polymerase chain reaction.
  
  
  RESULTS
  Chromosomal aberrations were observed in 56 (3.2%) cases. About 44.6% of the abnormalities detected were numerical aberrations; however, 55.3% of the abnormalities were structural aberrations. Abnormalities detected were inversion of chromosome 9 in 20 cases, trisomy 21 in 14 cases, 46,XX/47,XX, +21 in 1 case, trisomy 18 in 2 cases, trisomy 13 in 1 case, 47,XXY, in 1 case, 45,X, in 1 case, structural abnormalities in 12 cases, and mosaic or tetraploidy in 6 cases.
  
  
  CONCLUSIONS
  Second trimester triple test is an effective screening tool for detecting fetal Down syndrome in Turkish women.
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Demirhan
authors.forename: Ayfer
authors.initials: A
authors.lastname: Pazarbaşı
authors.forename: Ali İrfan
authors.initials: Aİ
authors.lastname: Güzel
authors.forename: Deniz
authors.initials: D
authors.lastname: Taştemir
authors.forename: Bertan
authors.initials: B
authors.lastname: Yilmaz
authors.forename: Mülkiye
authors.initials: M
authors.lastname: Kasap
authors.forename: Fatma Tuncay
authors.initials: FT
authors.lastname: Özgünen
authors.forename: Cüneyt
authors.initials: C
authors.lastname: Evrüke
authors.forename: Cansun
authors.initials: C
authors.lastname: Demir
authors.forename: Erdal
authors.initials: E
authors.lastname: Tunç
authors.forename: Sabriye
authors.initials: S
authors.lastname: Kocatürk-Sel
authors.forename: Dilge
authors.initials: D
authors.lastname: Onatoğlu-Arikan
authors.forename: Semra
authors.initials: S
authors.lastname: Koç
authors.forename: Onur
authors.initials: O
authors.lastname: Özer
authors.forename: Nihal
authors.initials: N
authors.lastname: İnandiklioğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis / Q000379:methods*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D015203:Reproducibility of Results; D044967:Serum / Q000378:metabolism; D014421:Turkey; D055815:Young Adult