title: Alterations in the contractile phenotype of the bladder: lessons for understanding physiological and pathological remodelling of smooth muscle.
abstract: The contractile properties of the urinary bladder are changed by the conditions of normal development and partial bladder outlet obstruction. This change in the contractile phenotype is accompanied by changes in the regulatory cascades and filaments that regulate contractility. This review focuses on such changes during the course of normal development and in response to obstruction. Our goal is to discuss the experimental evidence that has accumulated from work in animal models and correlate these findings with the human voiding phenotype.
authors.affiliation: The John W Duckett Jr Center for Pediatric Urology at The Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA 19104, USA. zderic@email.chop.edu
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Zderic
authors.forename: Samuel
authors.initials: S
authors.lastname: Chacko
mesh_terms: D000818:Animals; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development; D018994:Myosin Light Chains / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism; D011817:Rabbits; D001743:Urinary Bladder / Q000033:anatomy & histology / Q000473:pathology* / Q000502:physiology*; D001748:Urinary Bladder Neck Obstruction / Q000473:pathology*
chemical_list: D018994:Myosin Light Chains; D009842:Oligopeptides