title: Prenatal exposure to carbon black (printex 90): effects on sexual development and neurofunction.
abstract: Maternal pulmonary exposure to ultrafine particles during pregnancy may affect the health of the child. Developmental toxicity of carbon black (Printex 90) nanoparticles was evaluated in a mouse model. Time-mated mice were intratracheally instilled with Printex 90 dispersed in Millipore water on gestation days (GD) 7, 10, 15 and 18, with total doses of 11, 54 and 268 μg Printex 90/animal. The female offspring prenatally exposed to 268 μg Printex 90/animal displayed altered habituation pattern during the Open field test.
authors.affiliation: National Research Centre for the Working Environment, Copenhagen, Denmark.
authors.forename: Petra
authors.initials: P
authors.lastname: Jackson
authors.forename: Ulla
authors.initials: U
authors.lastname: Vogel
authors.forename: Håkan
authors.initials: H
authors.lastname: Wallin
authors.forename: Karin S
authors.initials: KS
authors.lastname: Hougaard
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005865:Gestational Age; D019570:Inhalation Exposure / Q000009:adverse effects; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D051379:Mice; D008815:Mice, Inbred Strains; D009420:Nervous System / Q000187:drug effects* / Q000254:growth & development; D011014:Pneumonia / Q000139:chemically induced; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000503:physiopathology / Q000523:psychology; D012741:Sexual Maturation / Q000187:drug effects*; D053260:Soot / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D053260:Soot