title: Collagen type I, collagen type III, and versican in vocal fold lamina propria.
abstract: OBJECTIVE
  To analyze the distributions of collagen type I, collagen type III, and versican in the lamina propria of the human vocal fold.
  
  
  METHODS
  Cross-sectional analysis of cadaveric vocal folds of adult human larynges.
  
  
  METHODS
  Academic tertiary referral center.
  
  
  METHODS
  Larynges harvested at autopsy from 10 adult men and 10 adult women.
  
  
  METHODS
  Immunohistochemical reactions were performed using antihuman monoclonal antibodies to analyze the expression of collagen type I, collagen type III, and versican.
  
  
  RESULTS
  Collagen type I density was lower in the intermediate layer compared with the superficial and deep layers of vocal folds. Collagen type III density was lower in the intermediate layer compared with the deep layer. Versican density was lower in the superficial layer compared with the intermediate and deep layers. Versican density was lower in the lamina propria of women compared with men; this difference was noted in the superficial layer only. There was a positive correlation between collagen type III and versican densities within the lamina propria.
  
  
  CONCLUSIONS
  Collagen type I, collagen type III, and versican are distributed differently within the lamina propria layers of the adult vocal folds.
authors.affiliation: Department of Otolaryngology, University of São Paulo School of Medicine, Brazil. rbbuhler@uol.com.br
authors.forename: Rogerio B
authors.initials: RB
authors.lastname: Bühler
authors.forename: Luiz U
authors.initials: LU
authors.lastname: Sennes
authors.forename: Domingos H
authors.initials: DH
authors.lastname: Tsuji
authors.forename: Thais
authors.initials: T
authors.lastname: Mauad
authors.forename: Luiz
authors.initials: L
authors.lastname: Ferraz da Silva
authors.forename: Paulo N
authors.initials: PN
authors.lastname: Saldiva
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002102:Cadaver; D024042:Collagen Type I / Q000378:metabolism*; D024061:Collagen Type III / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism*; D012727:Sex Characteristics; D053675:Versicans / Q000378:metabolism*; D014827:Vocal Cords / Q000378:metabolism*
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III; D053675:Versicans