title: Protective effect of N-acetylcysteine on early outcomes of deceased renal transplantation.
abstract: We investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment (n = 38) or control (n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days (P = .026) and at 1 year after transplantation (P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group (P = .017) and these recipients required fewer days of dialysis (P = .012). Oxidative stress was significantly attenuated with NAC (P < .001). Our results suggested that NAC enhanced early outcomes of deceased donor renal transplantation by attenuating oxidative stress.
authors.affiliation: Division of Urology, Department of Surgery, University of Sao Paulo General Hospital, Sao Paulo, Brazil. alexandre.danilovic@sbu.org.br
authors.forename: A
authors.initials: A
authors.lastname: Danilovic
authors.forename: A M
authors.initials: AM
authors.lastname: Lucon
authors.forename: M
authors.initials: M
authors.lastname: Srougi
authors.forename: M H M
authors.initials: MH
authors.lastname: Shimizu
authors.forename: L E
authors.initials: LE
authors.lastname: Ianhez
authors.forename: W C
authors.initials: WC
authors.lastname: Nahas
authors.forename: A C
authors.initials: AC
authors.lastname: Seguro
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage*; D000328:Adult; D002102:Cadaver; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014019:Tissue Donors
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D000111:Acetylcysteine