title: Variants in COMT and DBH influence on response inhibition ability in Chinese Han females.
abstract: Catechol-O-methyltransferase (COMT) and dopamine-beta hydroxylase (DBH) are key enzymes to breakdown dopamine. Some previous studies have indicated that val158met in COMT and 19 bp insertion/deletion in 5' flank of DBH are related to the performance of executive function. To further investigate the associations of the two genes with executive function, we performed a population-based study in a Chinese Han population. The results indicated that val158met in COMT and the 19 bp insertion/deletion of DBH were associated with the average reaction time of response inhibition in female group (P = 0.01, P = 0.03), respectively. Furthermore, there was a significant interaction of the two genes on the reaction time (P = 0.006). This present study suggests that not only do COMT and DBH influence independently on response inhibition in females, but also exert a significant interaction on response inhibition.
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health, Northwest University, Xi'an 710069, China.
authors.forename: Pingyuan
authors.initials: P
authors.lastname: Gong
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Wanyu
authors.initials: W
authors.lastname: Chi
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Tianbao
authors.initials: T
authors.lastname: Yao
authors.forename: Kejin
authors.initials: K
authors.lastname: Zhang
authors.forename: Xiaocai
authors.initials: X
authors.lastname: Gao
authors.forename: Fuchang
authors.initials: F
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004298:Dopamine / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D004299:Dopamine beta-Hydroxylase; D002394:Catechol O-Methyltransferase; D004298:Dopamine