title: Cerebral perfusion pressure, microdialysis biochemistry, and clinical outcome in patients with spontaneous intracerebral hematomas.
abstract: OBJECTIVE
  The aim of our study was to investigate the roles of cerebral perfusion pressure (CPP) and microdialysis marker values on the clinical outcome of patients with spontaneous intracerebral hematoma.
  
  
  METHODS
  Twenty-seven patients (18 men; mean ± SD age, 54.17 ± 10.05 years; 9 women, mean ± SD age, 65.00 ± 4.24 years) with a GCS of 8 or less upon admission were included in this study. After a 6-month follow-up period, a linear regression model was applied to evaluate the outcomes using the Glasgow Outcome Scale (GOS).
  
  
  RESULTS
  Of the 27 patients, 16 died within the first 6 months after discharge from the hospital. Six patients had a favorable prognosis after 6 months. In the patients who had a favorable outcome (GOS = 4 or GOS = 5), the CPP was above 75.46 mm Hg, and intracranial pressure was below 14.21 mm Hg. No patient with a favorable prognosis had a lactate-pyruvate (L/P) ratio greater than 37.40. An inverse linear relationship was found among the L/P ratio, the CPP, and patient outcome.
  
  
  CONCLUSIONS
  The L/P ratio and CPP were found to be related to patient outcome. In addition, a CPP greater than 75.46 mm Hg and an L/P ratio lower than 37.40 mm Hg were related to a favorable outcome.
authors.affiliation: Intensive Care Unit, General Hospital of Larissa, Greece.
authors.forename: Irene
authors.initials: I
authors.lastname: Nikaina
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Paterakis
authors.forename: Geogios
authors.initials: G
authors.lastname: Paraforos
authors.forename: Efthimios
authors.initials: E
authors.lastname: Dardiotis
authors.forename: Achilleas
authors.initials: A
authors.lastname: Chovas
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Papadopoulos
authors.forename: Alexandros
authors.initials: A
authors.lastname: Brotis
authors.forename: Apostolos
authors.initials: A
authors.lastname: Komnos
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000378:metabolism / Q000401:mortality / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D023261:Glasgow Outcome Scale; D006406:Hematoma / Q000378:metabolism / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D007427:Intracranial Pressure; D016014:Linear Models; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D011379:Prognosis
chemical_list: D015415:Biomarkers