title: Fibrin-targeted block copolymers for the prevention of postsurgical adhesions.
abstract: Despite advances in surgical methods, postsurgical adhesions (PSA) remain a significant clinical challenge affecting millions of patients each year. These permanent fibrous connections between tissues result from the bridging of wounded internal surfaces by an extended fibrin gel matrix (FGM). Adhesion formation is a result of a systems level convergence of wound healing pathways, complicating the design of materials that could inhibit their occurrence. In this study, a systematic approach that identifies key material properties required for functional performance optimization was used to design a new fibrin-targeted PSA prevention material. A series of multifunctional polymers with varied molecular architectures was synthesized to investigate the effect of changing polymer structural parameters on the ability to disrupt the formation of an extended FGM. Initial studies in a murine adhesion model demonstrated a statistically significant reduction in the degree of PSA formation, demonstrating the potential value of this systematic approach.
authors.affiliation: Centre College, Danville, Kentucky 40422, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Medley
authors.forename: Eugene
authors.initials: E
authors.lastname: Kaplan
authors.forename: Helieh S
authors.initials: HS
authors.lastname: Oz
authors.forename: Sharath C
authors.initials: SC
authors.lastname: Sundararaj
authors.forename: David A
authors.initials: DA
authors.lastname: Puleo
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Dziubla
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D005260:Female; D005337:Fibrin / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*; D046509:Tissue Culture Techniques
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D005337:Fibrin