title: A congenital case of circumscribed acral hypokeratosis.
abstract: Circumscribed acral hypokeratosis is a disorder characterized by areas of erythematous depressed skin with distinct histopathological findings typically found on the palmar and plantar surfaces. Most patients are middle-aged women who report a multiyear history. We present an 10-year-old African American boy who had an asymptomatic, irregularly shaped erythematous lesion on his left medial foot that had been present since birth. A biopsy showed an abrupt, well-demarcated decrease in the thickness of the stratum corneum layer, with no parakeratosis, that was consistent with a diagnosis of circumscribed hypokeratosis. This represents the first pediatric and congenital case of circumscribed hypokeratosis reported. We review the literature and discuss the ramifications of a congenital case on understanding the etiology of circumscribed hypokeratosis.
authors.affiliation: Department of Dermatology, School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, New York 14222, USA
authors.forename: Joshua
authors.initials: J
authors.lastname: Arbesman
authors.forename: Lesley C
authors.initials: LC
authors.lastname: Loss
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Helm
authors.forename: Ilene L
authors.initials: IL
authors.lastname: Rothman
mesh_terms: D002648:Child; D004817:Epidermis / Q000473:pathology*; D005533:Foot Dermatoses / Q000151:congenital* / Q000473:pathology*; D006801:Humans; D015603:Keratinocytes / Q000473:pathology*; D007642:Keratosis / Q000473:pathology*; D008297:Male