title: Novel therapies targeting endometriosis.
abstract: Endometriosis is an often painful disorder in which the endometrial glands and stroma grow outside the uterus. The disease affects women's quality of life and is a common cause of infertility. In this review, we describe promising new developments in the field based on in vitro assays and rodent models, each of which has the potential to be beneficial in the treatment of this disease. We will specifically describe the role of anti-inflammatory drugs, selective estrogen, or progesterone modulators, statins, antiangiogenic agents, and the potential for targeting stem cells as likely methods to hone in and eliminate endometriosis. The most promising of these potential therapies are currently slated for further testing in both rodent and nonhuman primate trials.
authors.affiliation: Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University, 333 Cedar Street, New Haven, CT 06520, USA. hugh.taylor@yale.edu
authors.forename: Hugh S
authors.initials: HS
authors.lastname: Taylor
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Osteen
authors.forename: Kaylon L
authors.initials: KL
authors.lastname: Bruner-Tran
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Lockwood
authors.forename: Graciela
authors.initials: G
authors.lastname: Krikun
authors.forename: Anna
authors.initials: A
authors.lastname: Sokalska
authors.forename: Antoni J
authors.initials: AJ
authors.lastname: Duleba
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use
chemical_list: D020533:Angiogenesis Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D020845:Selective Estrogen Receptor Modulators