title: Epithelioid angiosarcoma of the kidney: a diagnostic dilemma in fine-needle aspiration cytology.
abstract: Epithelioid angiosarcomas (EAS) of kidney are rare and aggressive tumors with noncharacteristic imaging features that overlap with those of inflammatory conditions and renal cell carcinoma (RCC). We report the fine-needle aspiration (FNA) cytology findings of a case of EAS that involved the left kidney of an 83-year-old male. The smears and cell block sections showed pleomorphic epithelioid cells with ample cytoplasm, eccentric nuclei, occasional cytoplasmic hyaline globules, and rare intracytoplasmic lumina. Immunohistochemical stains performed on cellblock sections showed that the tumor cells were positive for vimentin, CD31, CD34, Factor VIII, and CD10, but showed no staining for cytokeratins AE1/AE3 and 8/18, HMB45, CD45, smooth muscle actin, and S100. The morphological and immunohistochemical distinction between EAS, primary tumors of the kidney, and other epithelioid and rhabdoid neoplasms is discussed.
authors.affiliation: Department of Laboratory Medicine & Pathology, University of Minnesota Medical School, 420 Delaware SE, Minneapolis, MN 55455, USA.
authors.forename: Charanjeet
authors.initials: C
authors.lastname: Singh
authors.forename: Linjun
authors.initials: L
authors.lastname: Xie
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Schmechel
authors.forename: J Carlos
authors.initials: JC
authors.lastname: Manivel
authors.forename: Stefan E
authors.initials: SE
authors.lastname: Pambuccian
mesh_terms: D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D002449:Cell Aggregation; D002467:Cell Nucleus / Q000473:pathology; D003937:Diagnosis, Differential; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000473:pathology*; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology*; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D011860:Radiography, Abdominal; D014057:Tomography, X-Ray Computed