title: Human herpesvirus type 6 hepatitis or familiar intrahepatic cholestasis: the importance of follow-up.
abstract: A 1-month-old child presented to our unit with jaundice and raised aminotransferases, γ-glutamyltranspeptidase and bilirubin. Metabolic diseases were ruled out and ultrasound found no alterations. Human herpesvirus type 6 (HHV-6) DNA was found in blood and saliva and IgG anti-HHV-6 in serum, and a diagnosis of HHV-6 hepatitis was made. In the following weeks, aminotransferase values remained raised while γ-glutamyltranspeptidase levels returned to normal in 45 days. At the age of 5 months symptoms and elevated aminotransferases persisted and immunohistochemistry performed on liver tissue allowed a diagnosis of progressive familiar intrahepatic cholestasis type 2 to be made. The patient is now 7 months old, and cholestatic jaundice and pruritus continue to be present.
authors.affiliation: Bambino Gesu Children's Hospital, S.Onofrio 4 square, Rome, 00165, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Nobili
authors.forename: Andrea
authors.initials: A
authors.lastname: Pietrobattista
authors.forename: Paola
authors.initials: P
authors.lastname: Francalanci
authors.forename: Ilaria
authors.initials: I
authors.lastname: Giovannoni
authors.forename: Matilde
authors.initials: M
authors.lastname: Marcellini
authors.forename: Sandro
authors.initials: S
authors.lastname: Vento