title: Nitric oxide inhalation, a proposed strategy for early treatment of hemorrhagic shock.
abstract: Nitric oxide (NO), an endothelial-derived relaxing factor, plays important roles in a variety of pathophysiological conditions such as hemorrhagic shock (HS). So far, the impact of NO administration in HS treatment has been controversial. Through literature review, we summarize here the biphasic effects of NO in early and late phases of HS. Evidence suggests that NO administration is beneficial in the early stage while detrimental in the late stage of HS. We further propose inhalation of NO as a novel therapeutic strategy for the treatment of HS in the early stage.
authors.affiliation: Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Guoxing
authors.initials: G
authors.lastname: You
authors.forename: Xuemei
authors.initials: X
authors.lastname: Kan
authors.forename: Gan
authors.initials: G
authors.lastname: Chen
authors.forename: Lian
authors.initials: L
authors.lastname: Zhao
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000280:Administration, Inhalation; D006801:Humans; D008954:Models, Biological; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000628:therapy*
chemical_list: D009569:Nitric Oxide