title: Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving oxcarbazepine.
abstract: OBJECTIVE
  The aim of this study was to investigate whether oxcarbazepine (OXC) monotherapy causes weight gain in epileptic children.
  
  
  METHODS
  A total of 22 children with epilepsy (age 3.0-16.4 years) were assigned to OXC therapy. Serum levels of glucose, insulin, cortisol, leptin, neuropeptide Y (NPY), galanin and ghrelin were assessed before OXC therapy (month 0) and after the 6th and 18th months.
  
  
  RESULTS
  There was no statistically significant difference in weight-standard deviation score (SDS), Height-SDS, BMI-SDS, serum glucose, insulin, cortisol, leptin, NPY, galanin and ghrelin levels between initial values (month 0) and those in the 6th and 18th months after OXC therapy (p > 0.05).
  
  
  CONCLUSIONS
  Our results indicate that OXC therapy causes neither weight change nor alterations in serum glucose, insulin, cortisol, leptin, NPY, galanin and ghrelin levels in children with epilepsy.
authors.affiliation: Department of Pediatric Neurology, Karadeniz Technical University Faculty of Medicine, 61080 Trabzon, Turkey. acansu2003@yahoo.com
authors.forename: Ali
authors.initials: A
authors.lastname: Cansu
authors.forename: Ayse
authors.initials: A
authors.lastname: Serdaroglu
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinaz
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D019004:Galanin / Q000097:blood*; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D000078330:Oxcarbazepine
chemical_list: D000927:Anticonvulsants; D001786:Blood Glucose; D054439:Ghrelin; D007328:Insulin; D009478:Neuropeptide Y; D002220:Carbamazepine; D019004:Galanin; D000078330:Oxcarbazepine; D006854:Hydrocortisone