title: Volumetric measurement for comparison of the accuracy between intraoperative CT and postoperative MR imaging in pituitary adenoma surgery.
abstract: OBJECTIVE
  To improve the resection rate of unexpected residual pituitary tumor under image guidance, iCT provides a less time-consuming and more convenient approach of promising the safety of the trans-sphenoidal surgery. However, iCT was thought to have worse image quality than MR imaging. This study was designed to determine the predictive concordance of iCT with standard postoperative high-strength MR imaging for the detection of residual tumors.
  
  
  METHODS
  From February to December 2009, 33 patients with pituitary macroadenomas were enrolled in this prospective study. All patients received endoscopic trans-sphenoidal surgery for tumor removal and underwent iCT before the surgery finished. If an accessible tumor remnant was suspected and resectable, the surgery was continued. To assess the accuracy of intraoperative evaluation of tumor resection, the intraoperative findings were compared with MR imaging findings obtained 2 to 3 months after surgery by individually calculating the residual tumor volume.
  
  
  RESULTS
  There were no statistically significant differences in the comparison between iCT and postoperative MR imaging findings (P > .05), and the predictive rates were also high (R(2) value >0.9). The GTR rate in the case of the noninvasive and fresh cases was 89% (17/19). The overall GTR rate was 58% (19/33), the second-look rate was 21% (7/33), and only one-fourth of the recurrent cases reached GTR.
  
  
  CONCLUSIONS
  The extent of resection in trans-sphenoidal surgery can be reliably assessed by iCT. Compared with postoperative MR imaging findings, the findings in this study provided quantitative evidence that iCT not only holds significant promise for maximizing the extent of tumor resection but also eliminates the unnecessary blind surgical manipulation, thus increasing the safety of the procedure.
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, Republic of China.
authors.forename: C-C
authors.initials: CC
authors.lastname: Lee
authors.forename: S-T
authors.initials: ST
authors.lastname: Lee
authors.forename: C-N
authors.initials: CN
authors.lastname: Chang
authors.forename: P-C
authors.initials: PC
authors.lastname: Pai
authors.forename: Y-L
authors.initials: YL
authors.lastname: Chen
authors.forename: T-C
authors.initials: TC
authors.lastname: Hsieh
authors.forename: C-C
authors.initials: CC
authors.lastname: Chuang
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D011182:Postoperative Care; D011446:Prospective Studies; D015203:Reproducibility of Results; D055815:Young Adult