title: Antiproliferative effects of metal complexes of new isatin hydrazones against HCT116, MCF7 and HELA tumour cell lines.
abstract: New hydrazone ligands (HL) derived from 5-substituted isatins and 1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)hydrazines and its complexes with Co(II) and Cu(II) were synthesized. The new hydrazones and their complexes were characterized by means of elemental, spectral analyses and magnetic studies. Primary cytotoxicity evaluation of HL 5a and the new complexes showed that these complexes could act as anticancer agents since they reduced the growth of samples of human tumour cell lines (HCT116((Colon)), MCF7((Breast)) and HELA((Cervix))) to ≤18.5 μg/mL for the new complexes.
authors.affiliation: Department of Chemistry, Faculty of Women, Ain Shams University, Heliopolis, Cairo, Egypt. nadiaghk@yahoo.com
authors.forename: Nadia G
authors.initials: NG
authors.lastname: Kandile
authors.forename: Mansoura I
authors.initials: MI
authors.lastname: Mohamed
authors.forename: Hind M
authors.initials: HM
authors.lastname: Ismaeel
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D006835:Hydrazones / Q000737:chemistry*; D007510:Isatin / Q000031:analogs & derivatives / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D006835:Hydrazones; D009942:Organometallic Compounds; D003035:Cobalt; D003300:Copper; D007510:Isatin