title: Atypical response to treatment in linear IgA bullous dermatosis of childhood: Revision of literature.
abstract: A three-year-old boy presented with 2 months of worsening skin lesions characterized by multiple clear vesicles and bullae. The histopathological and immunohistochemical examinations revealed changes consistent with linear IgA bullous dermatosis of childhood. Treatment with dapsone and prednisolone resulted in gradual clinical improvement. However, within a week of therapy he presented with diabetic ketoacidosis, the onset of type I diabetes mellitus. Since then, keeping this child asymptomatic has been a challenge. This case emphasizes the importance of close monitoring of patients taking systemic corticosteroids; the coexistence of other immune mediated conditions may influence the success of treatment.
authors.affiliation: Hospital de Faro.
authors.forename: Susana
authors.initials: S
authors.lastname: Moleiro
authors.forename: Vera
authors.initials: V
authors.lastname: Santos
authors.forename: Manuela
authors.initials: M
authors.lastname: Calha
authors.forename: Graça
authors.initials: G
authors.lastname: Pessoa
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D016883:Diabetic Ketoacidosis / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D006442:Glycated Hemoglobin / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D011239:Prednisolone / Q000009:adverse effects* / Q000627:therapeutic use; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D003622:Dapsone; D006442:Glycated Hemoglobin; D006680:HLA Antigens; D007070:Immunoglobulin A; D016756:Immunoglobulins, Intravenous; D011239:Prednisolone; C517652:hemoglobin A1c protein, human