title: Association of serum retinol-binding protein 4 with insulin resistance and metabolic parameters during olanzapine therapy.
abstract: OBJECTIVE
  Retinol-binding protein 4 (RBP4) has been shown to be associated with insulin resistance (IR), metabolic indices and metabolic syndrome (MetS) in various patient populations and in obesity. We investigated the association between metabolic parameters, IR and RBP4 during olanzapine therapy.
  
  
  METHODS
  A prospective study.
  
  
  METHODS
  Thirty-seven participants with psychiatric disorder who were atypical antipsychotic naive and newly initiated on olanzapine were assessed.
  
  
  METHODS
  Fasting RBP4, anthropometric and metabolic variables were measured before and after 3 months of olanzapine therapy.
  
  
  RESULTS
  Participants who developed MetS showed higher RBP4 levels compared with those without MetS, although not significant (P = 0·053). The variation in RBP4 level was correlated with changes in systolic blood pressure (r = 0·423, P = 0·009), diastolic blood pressure (r = 0·390, P = 0·017), total cholesterol (r = 0·446, P = 0·006) and low-density lipoprotein (LDL) (r = 0·407, P = 0·012). Multiple linear regression analysis illustrated that end-point log insulin level was the most significant independent predictor of final log RBP4 levels (standardized ß = 0·353, P = 0·024).
  
  
  CONCLUSIONS
  Our results suggest that RBP4 levels might be associated with at least some olanzapine-induced metabolic abnormalities and cardiovascular disease risk factors.
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Toktam
authors.initials: T
authors.lastname: Faghihi
authors.forename: Mania
authors.initials: M
authors.lastname: Radfar
authors.forename: Elahe
authors.initials: E
authors.lastname: Abdoli
authors.forename: Homayoun
authors.initials: H
authors.lastname: Amini
authors.forename: Mohsen Rezaei
authors.initials: MR
authors.lastname: Hemami
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000209:etiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D000077152:Olanzapine; D011446:Prospective Studies; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis* / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D001569:Benzodiazepines; D000077152:Olanzapine