title: Automatic segmentation of intracochlear anatomy in conventional CT.
abstract: Cochlear implant surgery is a procedure performed to treat profound hearing loss. Clinical results suggest that implanting the electrode in the scala tympani, one of the two principal cavities inside the cochlea, may result in better hearing restoration. Segmentation of intracochlear cavities could thus aid the surgeon to choose the point of entry and angle of approach that maximize the likelihood of successful implant insertion, which may lead to more substantial hearing restoration. However, because the membrane that separates the intracochlear cavities is too thin to be seen in conventional in vivo imaging, traditional segmentation techniques are inadequate. In this paper, we circumvent this problem by creating an active shape model with micro CT (μCT) scans of the cochlea acquired ex vivo. We then use this model to segment conventional CT scans. The model is fitted to the partial information available in the conventional scans and used to estimate the position of structures not visible in these images. Quantitative evaluation of our method, made possible by the set of μCTs, results in Dice similarity coefficients averaging 0.75. Mean and maximum surface errors average 0.21 and 0.80  mm.
authors.affiliation: Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37235, USA. jack.h.noble@vanderbilt.edu
authors.forename: Jack H
authors.initials: JH
authors.lastname: Noble
authors.forename: Robert F
authors.initials: RF
authors.lastname: Labadie
authors.forename: Omid
authors.initials: O
authors.lastname: Majdani
authors.forename: Benoit M
authors.initials: BM
authors.lastname: Dawant
mesh_terms: D000465:Algorithms; D006801:Humans; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012533:Scala Tympani / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D054738:Scala Vestibuli / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055114:X-Ray Microtomography