title: Subretinal gene delivery using helper-dependent adenoviral vectors.
abstract: This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector.
authors.affiliation: Physiology and Experimental Medicine Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada. jim.hu@utoronto.ca.
authors.forename: Linda
authors.initials: L
authors.lastname: Wu
authors.forename: Simon
authors.initials: S
authors.lastname: Lam
authors.forename: Huibi
authors.initials: H
authors.lastname: Cao
authors.forename: Rui
authors.initials: R
authors.lastname: Guan
authors.forename: Rongqi
authors.initials: R
authors.lastname: Duan
authors.forename: Derek
authors.initials: D
authors.lastname: van der Kooy
authors.forename: Rod
authors.initials: R
authors.lastname: Bremner
authors.forename: Robert S
authors.initials: RS
authors.lastname: Molday
authors.forename: Jim
authors.initials: J
authors.lastname: Hu