title: Enantioselective addition of allyltin reagents to amino aldehydes catalyzed with bis(oxazolinyl)phenylrhodium(III) aqua complexes.
abstract: Bis(oxazolinyl)phenylrhodium(III) aqua complexes, (Phebox)RhX₂(H₂O) [X = Cl, Br], were found to be efficient Lewis acid catalysts for the enantioselective addition of allyl- and methallyltributyltin reagents to amino aldehydes. The reactions proceed smoothly in the presence of 5-10 mol % of (Phebox)RhX₂(H₂O) complex at ambient temperature to give the corresponding amino alcohols with modest to good enantioselectivity (up to 94% ee).
authors.affiliation: Institute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580, Japan. motoyama@cm.kyushu-u.ac.jp
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Motoyama
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Sakakura
authors.forename: Toshihide
authors.initials: T
authors.lastname: Takemoto
authors.forename: Kayoko
authors.initials: K
authors.lastname: Shimozono
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aoki
authors.forename: Hisao
authors.initials: H
authors.lastname: Nishiyama
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D012238:Rhodium