title: Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
abstract: The antifungal spirocyclic guanidine alkaloid, ptilomycalin A, from marine sponge Monanchora arbuscula, inhibits melanogenesis of Cryptococcus neoformans in vitro through inhibition of biosynthesis of laccase in the melanin biosynthetic pathway with an IC(50) of 7.3 μM.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, United States.
authors.forename: Doralyn S
authors.initials: DS
authors.lastname: Dalisay
authors.forename: Jonel P
authors.initials: JP
authors.lastname: Saludes
authors.forename: Tadeusz F
authors.initials: TF
authors.lastname: Molinski
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D003453:Cryptococcosis / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology*; D042845:Laccase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008543:Melanins / Q000096:biosynthesis*; D011161:Porifera / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D006146:Guanidines; D008543:Melanins; C103200:ptilomycalin A; D042845:Laccase