title: Carboxybetaine methacrylate polymers offer robust, long-term protection against cell adhesion.
abstract: Films of poly(carboxybetaine methacrylate), poly(CBMA), grafted onto microetched gold slides are effective in preventing nonspecific adhesion of cells of different types. The degree of adhesion resistance is comparable to that achieved with the self-assembled monolayers, SAMs, of oligo(ethylene glycol) alkanethiolates. In sharp contrast to the SAMs, however, substrates protected with poly(CBMA) can be stored in dry state without losing their protective properties for periods up to 2 weeks.
authors.affiliation: Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
authors.forename: Goher
authors.initials: G
authors.lastname: Mahmud
authors.forename: Sabil
authors.initials: S
authors.lastname: Huda
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Kristiana
authors.initials: K
authors.lastname: Kandere-Grzybowska
authors.forename: Didzis
authors.initials: D
authors.lastname: Pilans
authors.forename: Shaoyi
authors.initials: S
authors.lastname: Jiang
authors.forename: Bartosz A
authors.initials: BA
authors.lastname: Grzybowski
mesh_terms: D000818:Animals; D001622:Betaine / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016466:CHO Cells; D002448:Cell Adhesion / Q000187:drug effects; D006224:Cricetinae; D019855:Ethylene Glycol / Q000737:chemistry; D005347:Fibroblasts / Q000187:drug effects*; D006046:Gold / Q000737:chemistry; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D011109:Polymethacrylic Acids; C517178:polycarboxybetaine methacrylate; D001622:Betaine; D006046:Gold; D019855:Ethylene Glycol