title: Synergistic effect of antituberculosis drugs and azoles in vitro against Histoplasma capsulatum var. capsulatum.
abstract: This study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plus triazoles for the mold form and ethambutol plus voriconazole for the yeast-like form. Further studies should evaluate these combinations in vivo.
authors.affiliation: Federal University of Ceará, Campus do Porangabussu, Rua Cel. Nunes de Melo, 1315, Rodolfo Teófilo, CEP 60430-275 Fortaleza, Ceará, Brazil. rossanacordeiro@ufc.br
authors.forename: Rossana de Aguiar
authors.initials: Rde A
authors.lastname: Cordeiro
authors.forename: Francisca Jakelyne de Farias
authors.initials: FJ
authors.lastname: Marques
authors.forename: Raimunda Sâmia Nogueira
authors.initials: RS
authors.lastname: Brilhante
authors.forename: Kylvia
authors.initials: K
authors.lastname: Rocha de Castro E Silva
authors.forename: Charles Ielpo
authors.initials: CI
authors.lastname: Mourão
authors.forename: Erica Pacheco
authors.initials: EP
authors.lastname: Caetano
authors.forename: Maria Auxiliadora Bezerra
authors.initials: MA
authors.lastname: Fechine
authors.forename: Joyce Fonteles
authors.initials: JF
authors.lastname: Ribeiro
authors.forename: Débora de Souza Collares Maia
authors.initials: Dde S
authors.lastname: Castelo-Branco
authors.forename: Rita Amanda Chaves
authors.initials: RA
authors.lastname: de Lima
authors.forename: Jacó Ricarte Lima
authors.initials: JR
authors.lastname: Mesquita
authors.forename: Andre Jalles
authors.initials: AJ
authors.lastname: Monteiro
authors.forename: Francisco Airton Castro
authors.initials: FA
authors.lastname: Rocha
authors.forename: Marcos Fábio Gadelha
authors.initials: MF
authors.lastname: Rocha
authors.forename: José Júlio Costa
authors.initials: JJ
authors.lastname: Sidrim
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D004977:Ethambutol / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology; D006658:Histoplasma / Q000187:drug effects*; D007538:Isoniazid / Q000494:pharmacology; D017964:Itraconazole / Q000494:pharmacology; D011718:Pyrazinamide / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole
chemical_list: D000995:Antitubercular Agents; D004338:Drug Combinations; D011743:Pyrimidines; D014230:Triazoles; D011718:Pyrazinamide; D017964:Itraconazole; D004977:Ethambutol; D015725:Fluconazole; D065819:Voriconazole; D007538:Isoniazid