title: Embedding a cardiac pulsatile model into an integrated model of the cardiovascular regulation for heart failure followup.
abstract: The analysis of followup data from patients suffering from heart failure is a difficult task, due to the complex and multifactorial nature of this pathology. In this paper, we present a coupled model, integrating a pulsatile heart into a model of the short to long-term regulations of the cardiovascular system. An interface method is proposed to couple these models, which present significantly different time scales. Results from a sensitivity analysis of the original and integrated models are proposed with simulations reproducing the main effects of the short- and long-term responses of an acute decompensated heart failure episode on a patient undergoing cardiac resynchronization therapy.
authors.affiliation: INSERM U642 Rennes, F35000, France. virginie.lerolle@univ-rennes1.fr
authors.forename: Virginie
authors.initials: V
authors.lastname: Le Rolle
authors.forename: David
authors.initials: D
authors.lastname: Ojeda
authors.forename: Alfredo I
authors.initials: AI
authors.lastname: Hernández
mesh_terms: D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D003198:Computer Simulation; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D008955:Models, Cardiovascular