title: Immunoglobulin A: A next generation of therapeutic antibodies?
abstract: Although immunoglobulin (Ig) A is commonly recognized as the most prevalent antibody subclass at mucosal sites with an important role in mucosal defense, its potential as a therapeutic monoclonal antibody is less well known. However, IgA has multifaceted anti-, non-, and pro-inflammatory functions that can be exploited for different immunotherapeutical strategies, which will be the focus of this review.
authors.affiliation: Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Jantine E
authors.initials: JE
authors.lastname: Bakema
authors.forename: Marjolein
authors.initials: M
authors.lastname: van Egmond
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods; D007239:Infections / Q000628:therapy*; D008958:Models, Molecular; D009369:Neoplasms / Q000628:therapy*; D017455:Receptors, IgE / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D017455:Receptors, IgE