title: Healing of the abdominal wall after parcial hepatectomy.
abstract: OBJECTIVE
  To evaluate the wound healing of the abdominal wall incision in hepatectomized rats as for the concentration of collagen, inflammatory reaction and angiogenesis.
  
  
  METHODS
  We used 48 rats randomly assigned to laparotomy with or without hepatectomy. The scars were studied in the 3rd, 7th and 14th postoperative days. We analyzed the density of collagen by the histochemical method and angiogenesis, by immunohistochemistry.
  
  
  RESULTS
  The analysis showed a lower total collagen concentration in skin and subcutaneous tissue in the abdominal scars of the experiment group (p3 = 0.011, p7 = 0.004 and p14 = 0.008). The density of collagen I was lower in the hepatectomy group, especially in the third day, in the skin, subcutaneous tissue (p = 0.038) and in the aponeurotic plane (p = 0.026). There was a lower concentration of collagen III in the two abdominal wall layers studied, although not statistically significant. The inflammatory response was similar at all times in both groups. It was found that angiogenesis was developed earlier in the control group (p3 = 0.005 and p7 = 0.012) and later in the experimental group (p14 = 0.048).
  
  
  CONCLUSIONS
  Hepatectomy leads to a delay in the healing process, interfering with collagen synthesis and angiogenesis.
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina, UFPR, PR, BR. biondo@avalon.sul.com.br
authors.forename: Maria de Lourdes Pessole
authors.initials: Mde L
authors.lastname: Biondo-Simões
authors.forename: Flávia Thaiana
authors.initials: FT
authors.lastname: Bonato
authors.forename: Aline Moraes
authors.initials: AM
authors.lastname: Menacho
authors.forename: Mariana
authors.initials: M
authors.lastname: Drechmer
authors.forename: Tereza Cristina Santos
authors.initials: TC
authors.lastname: Cavalcanti
authors.forename: Saulo José Alves
authors.initials: SJ
authors.lastname: Felizola
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D006498:Hepatectomy / Q000379:methods; D008297:Male; D051381:Rats; D014945:Wound Healing