title: Fast network oscillations in vitro exhibit a slow decay of temporal auto-correlations.
abstract: Ongoing neuronal oscillations in vivo exhibit non-random amplitude fluctuations as reflected in a slow decay of temporal auto-correlations that persist for tens of seconds. Interestingly, the decay of auto-correlations is altered in several brain-related disorders, including epilepsy, depression and Alzheimer's disease, suggesting that the temporal structure of oscillations depends on intact neuronal networks in the brain. Whether structured amplitude modulation occurs only in the intact brain or whether isolated neuronal networks can also give rise to amplitude modulation with a slow decay is not known. Here, we examined the temporal structure of cholinergic fast network oscillations in acute hippocampal slices. For the first time, we show that a slow decay of temporal correlations can emerge from synchronized activity in isolated hippocampal networks from mice, and is maximal at intermediate concentrations of the cholinergic agonist carbachol. Using zolpidem, a positive allosteric modulator of GABA(A) receptor function, we found that increased inhibition leads to longer oscillation bursts and more persistent temporal correlations. In addition, we asked if these findings were unique for mouse hippocampus, and we therefore analysed cholinergic fast network oscillations in rat prefrontal cortex slices. We observed significant temporal correlations, which were similar in strength to those found in mouse hippocampus and human cortex. Taken together, our data indicate that fast network oscillations with temporal correlations can be induced in isolated networks in vitro in different species and brain areas, and therefore may serve as model systems to investigate how altered temporal correlations in disease may be rescued with pharmacology.
authors.affiliation: Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.
authors.forename: Simon-Shlomo
authors.initials: SS
authors.lastname: Poil
authors.forename: Rick
authors.initials: R
authors.lastname: Jansen
authors.forename: Karlijn
authors.initials: K
authors.lastname: van Aerde
authors.forename: Jaap
authors.initials: J
authors.lastname: Timmerman
authors.forename: Arjen B
authors.initials: AB
authors.lastname: Brussaard
authors.forename: Huibert D
authors.initials: HD
authors.lastname: Mansvelder
authors.forename: Klaus
authors.initials: K
authors.lastname: Linkenkaer-Hansen
mesh_terms: D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D018679:Cholinergic Agonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D058785:GABA-A Receptor Agonists / Q000494:pharmacology; D006624:Hippocampus / Q000033:anatomy & histology* / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008564:Membrane Potentials / Q000502:physiology*; D051379:Mice; D008811:Mice, Inbred DBA; D009415:Nerve Net / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology*; D010507:Periodicity; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000077334:Zolpidem
chemical_list: D018679:Cholinergic Agonists; D058785:GABA-A Receptor Agonists; D011725:Pyridines; D000077334:Zolpidem; D002217:Carbachol