title: Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad.
abstract: This study is the first systematic documentation of the potency of monovalent oral polio vaccine type 3 (mOPV3) kept at ambient temperatures during a polio immunization campaign in Chad. During the study test vials were exposed to temperatures of up to 47.1 °C, and kept outside of the 2-8 °C range for a maximum of 86.9 hours. Post-campaign laboratory testing confirmed that the test vials were still potent, and in conformity with the defined release specifications. Further, the Vaccine Vial Monitors performed as expected, giving an early warning indication of when cumulative exposure to heat reached levels that may have negatively affected the vaccine's potency. This study provides proof-of-concept evidence that certain types of OPV remain potent and thus can be kept, for limited periods of time, as well as administered at ambient temperatures.
authors.affiliation: PATH, Ferney-Voltaire, France. szipursky@path.org
authors.forename: Simona
authors.initials: S
authors.lastname: Zipursky
authors.forename: Liliane
authors.initials: L
authors.lastname: Boualam
authors.forename: Dah Ould
authors.initials: DO
authors.lastname: Cheikh
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Fournier-Caruana
authors.forename: Djabar
authors.initials: D
authors.lastname: Hamid
authors.forename: Mathias
authors.initials: M
authors.lastname: Janssen
authors.forename: Umit
authors.initials: U
authors.lastname: Kartoglu
authors.forename: Genevieve
authors.initials: G
authors.lastname: Waeterloos
authors.forename: Olivier
authors.initials: O
authors.lastname: Ronveaux
mesh_terms: D002596:Chad; D019411:Clinical Laboratory Techniques; D004356:Drug Storage; D006358:Hot Temperature; D006801:Humans; D007114:Immunization; D032541:Mass Vaccination; D011051:Poliomyelitis / Q000517:prevention & control; D011055:Poliovirus Vaccine, Oral / Q000276:immunology*; D012034:Refrigeration
chemical_list: D011055:Poliovirus Vaccine, Oral