title: Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182.
abstract: Enantioselective reductions of p-R(1)-C(6)H(4)C(O)CH(2)R(2) (R(1) = Cl, Br, CH(3), OCH(3), NO(2) and R(2) = Br, Cl) mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 afforded the corresponding halohydrins with complementary R and S configurations, respectively, in excellent yield and enantiomeric excesses. The obtained (R)- or (S)-halohydrins are important building blocks in chemical and pharmaceutical industries.
authors.affiliation: Institute of Chemistry, University of Campinas, CP 6154, 13084-971 Campinas, SP, Brazil.
authors.forename: Lucídio C
authors.initials: LC
authors.lastname: Fardelone
authors.forename: J Augusto R
authors.initials: JA
authors.lastname: Rodrigues
authors.forename: Paulo J S
authors.initials: PJ
authors.lastname: Moran