title: Stem cell therapies for type 1 diabetes mellitus.
abstract: The present review discusses the use of autologous hematopoietic stem cell transplantation (HSCT) for the treatment of diabetes mellitus type 1 (DM 1). It has been observed that high dose immunosuppression followed by HSCT shows better results among other immunotherapeutic treatments for the disease as the patients with adequate beta cell reserve achieve insulin independence. However, this response is not maintained and reoccurrence of the disease is major a major challenge to use HSCT in future to prevent or control relapse of DM 1.
authors.affiliation: Department of Clinical Medicine, RibeirBo Preto School of Medicine, University of São Paulo, Brazil. jcvoltar@fmrp.usp.br
authors.forename: Júilio C
authors.initials: JC
authors.lastname: Voltarelli
authors.forename: Carlos E B
authors.initials: CE
authors.lastname: Couri
authors.forename: Maria C
authors.initials: MC
authors.lastname: Rodrigues
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Moraes
authors.forename: Ana-Beatriz P L
authors.initials: AB
authors.lastname: Stracieri
authors.forename: Fabiano
authors.initials: F
authors.lastname: Pieroni
authors.forename: George
authors.initials: G
authors.lastname: Navarro
authors.forename: Angela M O
authors.initials: AM
authors.lastname: Leal
authors.forename: Belinda P
authors.initials: BP
authors.lastname: Simões
mesh_terms: D000818:Animals; D036101:Cord Blood Stem Cell Transplantation; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000276:immunology / Q000628:therapy*; D053595:Embryonic Stem Cells / Q000637:transplantation; D006402:Hematologic Diseases / Q000150:complications / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D050417:Insulin-Secreting Cells / Q000637:transplantation; D045164:Mesenchymal Stem Cell Transplantation; D051379:Mice; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous