title: [Peptic ulcer disease in liver cirrhosis: role of Helicobacter pylori infection and therapeutic approach].
abstract: Peptic ulcer has frequently been associated with liver cirrhosis. The death rate for peptic ulcer in cirrhotics has been reported to be five times higher than in general population. The underlying mechanisms are poorly understood. Different factors have been claimed to be involved, such as alterations in serum gastrin level, gastric acid secretions, mucosal blood flow and decreased prostaglandin production in gastric mucosa. Moreover, Helicobacter pylori infection, when accurately assessed, is detectable in most peptic ulcer cirrhotics. Since the H. pylori infection strongly correlates with peptic ulcer in general population, it is necessary to clarify the role of H. pylori in the pathogenesis of peptic ulcer in cirrhosis before eradication can be proposed as a preventive measure.
authors.affiliation: Universitatea de Medicină si Farmacie "Gr. T. Popa" Iaşi, Facultatea de Medicină, Institutul de Gastroenterologie si Hepatologie Iaşi.
authors.forename: Dana
authors.initials: D
authors.lastname: Mitrică
authors.forename: R
authors.initials: R
authors.lastname: Constantinescu
authors.forename: V L
authors.initials: VL
authors.lastname: Drug
authors.forename: C
authors.initials: C
authors.lastname: Stanciu
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy* / Q000401:mortality; D016480:Helicobacter pylori / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000401:mortality; D010437:Peptic Ulcer / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology* / Q000401:mortality; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents