title: [Pathogenic and tumorigenic effect of 1,2-dimethylhydrazine in mouse colon and ovarian].
abstract: OBJECTIVE
  To study the pathogenic and tumorigenic effect of 1,2-dimethylhydrazine (DMH) on the colon and ovaries of mice.
  
  
  METHODS
  Sixty ICR female mice were randomly divided into groups A and B for intraperitoneal injection of DMH (20 mg/kg) and saline (control) once a week for 24 weeks, respectively. The mice were sacrificed at 12, 16, 20, 24, 28 and 32 weeks after the first DMH injection for pathological examination of the colon and ovaries.
  
  
  RESULTS
  In group A, colorectal adenomas were found in 7, colorectal adenocarcinomas in 5, and hemorrhagic lesions of the ovaries with chronic inflammatory in 21 mice. Choriocarcinoma in the ovaries were detected in one mouse at 28 weeks and in another at 32 weeks. No obvious pathological changes were found in group B following the injections.
  
  
  CONCLUSIONS
  Intraperitoneal injection of DMH may induce colon tumors and ovarian diseases in mice.
authors.affiliation: Department of Pathology, Southern Medical University, Guangzhou 510515, China. lixin1102@yahoo.cn
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Yu
authors.forename: Qing-Ling
authors.initials: QL
authors.lastname: Zhang
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Ding
mesh_terms: D019813:1,2-Dimethylhydrazine / Q000633:toxicity*; D000818:Animals; D003106:Colon / Q000187:drug effects* / Q000473:pathology; D003110:Colonic Neoplasms / Q000139:chemically induced; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010049:Ovarian Diseases / Q000139:chemically induced; D010053:Ovary / Q000187:drug effects* / Q000473:pathology
chemical_list: D019813:1,2-Dimethylhydrazine