title: Partners in crime: ubiquitin-mediated degradation and autophagy.
abstract: Recent focus on autophagy research has led to new insights on the involvement of ubiquitin (Ub)-mediated signaling as a selectivity factor in autophagy, which is generally considered a nonselective global degradation system. Emerging reports have demonstrated active crosstalk between the Ub-dependent proteolytic system and autophagy. This article highlights recent reports describing Ub-mediated selective autophagy regulated by the Toll-like receptor 4-induced immune response.
authors.affiliation: Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA. shs77@pitt.edu
authors.forename: Shashikanth M
authors.initials: SM
authors.lastname: Sriram
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Han
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Kim
mesh_terms: D001343:Autophagy / Q000502:physiology*; D006801:Humans; D006868:Hydrolysis; D051197:Toll-Like Receptor 4 / Q000502:physiology; D025801:Ubiquitin / Q000502:physiology*; D054875:Ubiquitination
chemical_list: D051197:Toll-Like Receptor 4; D025801:Ubiquitin