title: Unusual cause of weight loss in a patient with HIV-hepatitis C virus coinfection.
abstract: Recombinant interferon α (IFN α), alone or in combination, is used extensively in the treatment of hepatitis C infection. IFN therapy is not free of side-effects and autoimmune thyroiditis is one of its rare side-effects. We present here a case of a patient with hepatitis C virus-human immunodeficiency virus coinfection on interferon therapy who presented with significant weight loss. He was found to have IFN-related autoimmune thyrotoxicosis and responded to antithyroid drugs and propanolol. Therefore, this case highlights that IFN-induced thyroiditis is an unusual side-effect and that during treatment, a thyroid-stimulating hormone assay should be performed at regular intervals (every 8-12 weeks).
authors.affiliation: Department of Medicine, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi - 110 060, India.
authors.forename: A
authors.initials: A
authors.lastname: Gogia
authors.forename: A
authors.initials: A
authors.lastname: Kakar