title: More effective nanomedicines through particle design.
abstract: Nanomedicine is an emerging field that applies concepts in nanotechnology to develop novel diagnostics and therapies. Physical and chemical properties of particles, including size, shape, modulus, surface charge and surface chemistry, play an important role in determining particle-cell interactions, cellular trafficking mechanisms, biodistribution, and pharmacokinetics. This discussion focuses on both nanoparticles and microparticles since microparticles can also provide many insights for the development of drug carriers and possess advantages over nanoparticles in certain applications. This review covers recent major advancement in the nanomedicine field and also highlights studies using the PRINT technology.
authors.affiliation: Department of Chemistry, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: James D
authors.initials: JD
authors.lastname: Byrne
authors.forename: Mary E
authors.initials: ME
authors.lastname: Napier
authors.forename: Joseph M
authors.initials: JM
authors.lastname: DeSimone
mesh_terms: D002477:Cells / Q000378:metabolism; D015195:Drug Design; D004705:Endocytosis; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D014018:Tissue Distribution