title: Adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor gamma coactivator 1α signaling provides neuroprotection in status epilepticus in rats.
abstract: Status epilepticus (SE) can cause severe neuronal loss and oxidative damage. Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) can be neuroprotective by inducing the antioxidant system, so we evaluated the role of PGC-1α in SE. The expression of PGC-1α and one of its target genes, uncoupling protein 2 (UCP2), was upregulated after SE, which may represent an endogenous neuroprotective mechanism. Furthermore, pretreatment with an adenosine monophosphate-activated protein kinase (AMPK) inhibitor significantly attenuated both AMPK and PGC-1α activation, followed by downregulation of UCP2 and enhanced oxidative stress and hippocampal neuronal damage. AMPK/PGC-1α may be neuroprotective in SE-induced brain damage, at least in part via UCP2.
authors.affiliation: Department of Neurology, Qilu Hospital, Shandong University, Jinan 250012, PR China.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Han
authors.forename: Nanchang
authors.initials: N
authors.lastname: Xie
authors.forename: Lili
authors.initials: L
authors.lastname: Cao
authors.forename: Xiuhe
authors.initials: X
authors.lastname: Zhao
authors.forename: Xuewu
authors.initials: X
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Zhaofu
authors.initials: Z
authors.lastname: Chi
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D002452:Cell Count; D006624:Hippocampus / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism; D008297:Male; D024101:Mitochondrial Proteins / Q000378:metabolism; D009474:Neurons / Q000473:pathology; D018384:Oxidative Stress; D047495:PPAR gamma / Q000378:metabolism*; D010862:Pilocarpine; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D000071246:Uncoupling Protein 2
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; D047495:PPAR gamma; C000604391:Ucp2 protein, rat; D000071246:Uncoupling Protein 2; D010862:Pilocarpine; D055372:AMP-Activated Protein Kinases