title: Schicagenins A-C: three cagelike nortriterpenoids from leaves and stems of Schisandra chinensis.
abstract: Schicagenins A-C (1-3), three unprecedented nortriterpenoids characterized with a tetracyclic oxa-cage motif and C(9) side chain, were discovered from the leaves and stems of Schisandra chinensis. Their structures were determined on the basis of extensive spectroscopic analysis, and the absolute stereochemistries were established by single-crystal X-ray diffraction and CD experiments. A plausible biosynthetic pathway of 1-3 was also discussed.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shi
authors.forename: Xing-Yao
authors.initials: XY
authors.lastname: Li
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Xiao
authors.initials: X
authors.lastname: Luo
authors.forename: Yong-Bo
authors.initials: YB
authors.lastname: Xue
authors.forename: Cheng-Qin
authors.initials: CQ
authors.lastname: Liang
authors.forename: Juan
authors.initials: J
authors.lastname: Zou
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Kong
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D014315:Triterpenes; C568563:schicagenin A; C568564:schicagenin B; C568565:schicagenin C