title: Effectiveness of preventive measures for hemato-oncologic patients undergoing stem cell transplantation during a period of hospital construction.
abstract: BACKGROUND
  Aspergillus spp are ubiquitous spore-forming fungi. Construction work, renovation, demolition, or excavation activities within a hospital or in surrounding areas increase the risk for aspergillus infection in susceptible patients and are the main cause of nosocomial aspergillus outbreaks.
  
  
  METHODS
  We investigated the efficacy of infection control measures on the frequency of fungal infection among hemato-oncologic patients undergoing stem cell transplantation during excavation and construction work of an adjacent hospital building. Clinical isolates from these patients obtained before and during the excavation and construction period were analyzed. Preventive measures consisted in the implementation of a multibarrier concept to protect these patients from fungal infection.
  
  
  RESULTS
  There was no record of any clinical isolate of Aspergillus spp in the observation period before the beginning of the groundwork. However, 3 clinically significant isolates of Aspergillus spp were detected in respiratory tract specimen of 2 patients after the beginning of excavation and demolition work, which were found to be community acquired.
  
  
  CONCLUSIONS
  Although our data cannot demonstrate the efficacy of infection control measures during construction work, it can be concluded that excavation work close to immunocompromised patients is safe if a bundle of preventive measures is implemented before groundwork.
authors.affiliation: Division of Hospital Hygiene, Clinical Institute for Hygiene and Medical Microbiology, Medical University Vienna, Austria.
authors.forename: Jutta
authors.initials: J
authors.lastname: Berger
authors.forename: Birgit
authors.initials: B
authors.lastname: Willinger
authors.forename: Magda
authors.initials: M
authors.lastname: Diab-Elschahawi
authors.forename: Alexander
authors.initials: A
authors.lastname: Blacky
authors.forename: Peter
authors.initials: P
authors.lastname: Kalhs
authors.forename: Walter
authors.initials: W
authors.lastname: Koller
authors.forename: Ojan
authors.initials: O
authors.lastname: Assadian
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Aichberger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001228:Aspergillosis / Q000517:prevention & control*; D001230:Aspergillus / Q000302:isolation & purification; D003428:Cross Infection / Q000517:prevention & control*; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications*; D006749:Hospital Design and Construction; D006801:Humans; D017053:Infection Control / Q000379:methods*; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D055815:Young Adult