title: Absorbable phenylpropenoyl sucroses from Polygala tenuifolia.
abstract: Three phenylpropenoyl sucroses--sibiricose A5, A6 and 3',6-disinapoyl sucrose--were isolated from the 30% EtOH extract of Polygala tenuifolia, which displayed antidepressant-like action. HPLC analysis indicated that the three phenylpropenoyl sucroses could be absorbed into serum. From the serum pharmacochemistry point of view, these three phenylpropenoyl sucroses might prevent or relieve depression.
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Gaimei
authors.initials: G
authors.lastname: She
authors.forename: Yinying
authors.initials: Y
authors.lastname: Ba
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Hang
authors.initials: H
authors.lastname: Lv
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Renbing
authors.initials: R
authors.lastname: Shi
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000493:pharmacokinetics*; D031801:Polygala / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044967:Serum / Q000737:chemistry; D013395:Sucrose / Q000031:analogs & derivatives / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts; C494904:sibiricose A6; D013395:Sucrose