title: Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis in mice.
abstract: The purpose of this study was to investigate the bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum on lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis. The results revealed that post-treatment with 100 μmol/kg trans-cinnamaldehyde, (-)-aromadendrene, T-cadinol, or α-cadinol significantly decreased the aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) levels in serum. Moreover, both T-cadinol and α-cadinol treatments decreased the expressions of cleaved caspase-3 and cleaved poly-ADP ribose polymerase (PARP) in the liver tissues when compared with the LPS/D-GalN group. Liver histopathology also showed that silymarin, trans-cinnamaldehyde, (-)-aromadendrene, T-cadinol, or α-cadinol significantly reduced the incidence of liver lesions induced by LPS/D-GalN. These results suggest that the above phytochemicals exhibit potent hepatoprotection against LPS/D-GalN-induced liver damage in mice, and their hepatoprotective effects may be due to the modulation of anti-inflammatory activities.
authors.affiliation: Department of Forestry, National Chung Hsing University, Taichung, Taiwan.
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Tung
authors.forename: Chi-Chang
authors.initials: CC
authors.lastname: Huang
authors.forename: Shang-Tse
authors.initials: ST
authors.lastname: Ho
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
authors.forename: Chi-Chen
authors.initials: CC
authors.lastname: Lin
authors.forename: Chien-Tsong
authors.initials: CT
authors.lastname: Lin
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Wu
mesh_terms: D000208:Acute Disease / Q000628:therapy; D000818:Animals; D027424:Cinnamomum / Q000737:chemistry*; D004195:Disease Models, Animal; D005688:Galactosamine / Q000009:adverse effects*; D006505:Hepatitis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008070:Lipopolysaccharides / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009822:Oils, Volatile / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000008:administration & dosage*
chemical_list: D008070:Lipopolysaccharides; D009822:Oils, Volatile; D010938:Plant Oils; D005688:Galactosamine