title: Influence of different cut-off values on the diagnosis of mild cognitive impairment in Parkinson's disease.
abstract: Comparable to Alzheimer's disease, mild cognitive impairment in Parkinson's disease (PD-MCI) is associated with an increased risk for dementia. However different definitions of PD-MCI may have varying predictive accuracy for dementia. In a cohort of 101 nondemented Parkinson patients who underwent neuropsychological testing, the frequency of PD-MCI subjects and PD-MCI subtypes (i.e., amnestic/nonamnestic) was determined by use of varying healthy population-based cut-off values. We also investigated the association between defined PD-MCI groups and ADL scales. Varying cut-off values for the definition of PD-MCI were found to affect frequency of PD-MCI subjects (9.9%-92.1%) and, maybe more important, lead to a "shift" of proportion of detected PD-MCI subtypes especially within the amnestic single-domain subtype. Models using a strict cut-off value were significantly associated with lower ADL scores. Thus, the use of defined cut-off values for the definition of PD-MCI is highly relevant for comparison purposes. Strict cut-off values may have a higher predictive value for dementia.
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Liepelt-Scarfone
authors.forename: Susanne
authors.initials: S
authors.lastname: Graeber
authors.forename: Anne
authors.initials: A
authors.lastname: Feseker
authors.forename: Gülsüm
authors.initials: G
authors.lastname: Baysal
authors.forename: Jana
authors.initials: J
authors.lastname: Godau
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gaenslen
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg