title: Analysis of GP73 in patients with HCC as a function of anti-cancer treatment.
abstract: In this study, we examined the level of Golgi protein 73 (GP73) in the serum of 9 patients as a function of anti-liver cancer treatment. Although the numbers are small, a clear trend was observed. Patients who remained tumor free (up to 6 years post-treatment) showed reductions in GP73 at the first time point available post-treatment. In contrast, patients who had high levels GP73 post treatment all had re-occurrence within a 5 year period. These data are preliminary but dramatically imply that this marker may have value in the monitoring of HCC patients and may be elevated even when small, undetectable tumors are present.
authors.affiliation: Liver Disease Prevention Center, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
authors.forename: Hie-Won
authors.initials: HW
authors.lastname: Hann
authors.forename: Mengjun
authors.initials: M
authors.lastname: Wang
authors.forename: Julie
authors.initials: J
authors.lastname: Hafner
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Long
authors.forename: Su Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Meejin
authors.initials: M
authors.lastname: Ahn
authors.forename: Susan
authors.initials: S
authors.lastname: Park
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Comunale
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Block
authors.forename: Anand
authors.initials: A
authors.lastname: Mehta
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000628:therapy*; D005260:Female; D006801:Humans; D015151:Immunoblotting; D008113:Liver Neoplasms / Q000378:metabolism / Q000628:therapy*; D008297:Male; D008565:Membrane Proteins / Q000032:analysis*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C410824:GOLM1 protein, human; D008565:Membrane Proteins