title: New approaches to disease mapping in admixed populations.
abstract: Admixed populations such as African Americans and Hispanic Americans are often medically underserved and bear a disproportionately high burden of disease. Owing to the diversity of their genomes, these populations have both advantages and disadvantages for genetic studies of complex phenotypes. Advances in statistical methodologies that can infer genetic contributions from ancestral populations may yield new insights into the aetiology of disease and may contribute to the applicability of genomic medicine to these admixed population groups.
authors.affiliation: Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA. mfseldin@ucdavis.edu
authors.forename: Michael F
authors.initials: MF
authors.lastname: Seldin
authors.forename: Bogdan
authors.initials: B
authors.lastname: Pasaniuc
authors.forename: Alkes L
authors.initials: AL
authors.lastname: Price
mesh_terms: D001741:Black or African American / Q000235:genetics*; D015415:Biomarkers; D002874:Chromosome Mapping / Q000379:methods*; D019295:Computational Biology / Q000379:methods; D005828:Genetics, Population / Q000379:methods*; D055106:Genome-Wide Association Study; D005838:Genotype; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide
chemical_list: D015415:Biomarkers