title: Long-term lead elimination from plasma and whole blood after poisoning.
abstract: OBJECTIVE
  Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
  
  
  METHODS
  A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
  
  
  RESULTS
  P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
  
  
  CONCLUSIONS
  P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
authors.affiliation: Division of Occupational and Environmental Medicine, Lund University, SE-221 85 Lund, Sweden. Gerda.Rentschler@med.lu.se
authors.forename: Gerda
authors.initials: G
authors.lastname: Rentschler
authors.forename: K
authors.initials: K
authors.lastname: Broberg
authors.forename: T
authors.initials: T
authors.lastname: Lundh
authors.forename: S
authors.initials: S
authors.lastname: Skerfving
mesh_terms: D000740:Anemia / Q000139:chemically induced / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D005260:Female; D006207:Half-Life; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007854:Lead / Q000378:metabolism / Q000493:pharmacokinetics* / Q000633:toxicity; D007855:Lead Poisoning / Q000097:blood* / Q000473:pathology; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008875:Middle Aged; D010949:Plasma; D000623:Porphobilinogen Synthase / Q000235:genetics; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D007854:Lead; D000623:Porphobilinogen Synthase