title: New Nanomedicine Approaches Using Gold-thioguanine Nanoconjugates as Metallo-ligands.
abstract: Gold-thioguanine nanoconjugates (AuNP-TG) of size 3-4 nm were synthesized and the ratio between gold and 6-Thioguanine (TG) was estimated as ~1:1.5 using a cyanide digestion method and confirmed by flame atomic absorption spectroscopic analysis. AuNP-TG constructs showed high in vitro stability under different pH conditions and biologically relevant solutions for a period of 24 hours. Reaction of AuNP-TG with europium or platinum salts resulted in the formation of organized self-assembled metallo-networks.
authors.affiliation: Department of Radiology, University of Missouri-Columbia, Columbia, MO 65212, USA.
authors.forename: Lee
authors.initials: L
authors.lastname: Sleightholm
authors.forename: Ajit
authors.initials: A
authors.lastname: Zambre
authors.forename: Nripen
authors.initials: N
authors.lastname: Chanda
authors.forename: Zahra
authors.initials: Z
authors.lastname: Afrasiabi
authors.forename: Kattesh
authors.initials: K
authors.lastname: Katti
authors.forename: Raghuraman
authors.initials: R
authors.lastname: Kannan