title: [IL-1beta, IL-10, INF-gamma, TNF-alpha, S100beta, AMA-M2 and cell immune response in stroke].
abstract: Clinical data showed a role for stress, inflammatory, innate immune and adaptive immune mechanisms is stroke. Absolute and relative count of lymphocytes decrease, CD3 HLA DR+ and immunoregulatory balance (CD4+/CD8+) increase, concentration of IL-1beta, INF-gamma, TNF-alpha, S100beta, AMA-M2 increase, IL-10 decrease were detected in peripheral blood of 25 patients with stroke. It is explained that the products of brain cell stroke destruction (AMA-M2) play in autoimmune stroke progress mechanisms the same role as neurospecific proteins as S100beta. It is concluded that both stereotype and autoimmune mechanisms are involved in the development of stroke.
authors.forename: S P
authors.initials: SP
authors.lastname: Sergeeva
authors.forename: L M
authors.initials: LM
authors.lastname: Erofeeva
authors.forename: M M
authors.initials: MM
authors.lastname: Gul'tiaev
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D015551:Autoimmunity; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000097:blood* / Q000276:immunology; D016753:Interleukin-10 / Q000097:blood* / Q000276:immunology; D053583:Interleukin-1beta / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood* / Q000276:immunology; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood* / Q000276:immunology; D020521:Stroke / Q000097:blood* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000276:immunology
chemical_list: D001323:Autoantibodies; C508609:IL10 protein, human; D053583:Interleukin-1beta; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma