title: Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase.
abstract: Non-alcoholic steatohepatitis (NASH) represents the progression of hepatic steatosis to streatohepatitis, fibrosis and cirrhosis. Three signaling pathways have been associated with this progression; Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. This review will describe how activation of these three pathways is required for development of fibrosis in murine models of NASH. The three pathways are related and synergistic through intracellular cross-talk. Disruption of any of these pathways may inhibit NASH-induced fibrosis and are potential targets for therapeutic intervention.
authors.affiliation: Department of Medicine, UC San Diego Health Sciences, La Jolla, California, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Brenner
authors.forename: Ekihiro
authors.initials: E
authors.lastname: Seki
authors.forename: Kojiro
authors.initials: K
authors.lastname: Taura
authors.forename: Tatiana
authors.initials: T
authors.lastname: Kisseleva
authors.forename: Samuele
authors.initials: S
authors.lastname: Deminicis
authors.forename: Keiko
authors.initials: K
authors.lastname: Iwaisako
authors.forename: Sayaka
authors.initials: S
authors.lastname: Inokuchi
authors.forename: Bernd
authors.initials: B
authors.lastname: Schnabl
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Oesterreicher
authors.forename: Yong H
authors.initials: YH
authors.lastname: Paik
authors.forename: Kouichi
authors.initials: K
authors.lastname: Miura
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Kodama