title: [Pathogenesis of NSAIDs-induced gastrointestinal ulcers].
abstract: It is necessary for some conditions to occur at the same time so that NSAIDs-induced gastrointestinal ulcers occur. The definite condition that is necessary for the development of ulcers by NSAIDs is the direct injury with NSAIDs and the presence and influences of the luminal factors, including gastric acid, bacteria, and bile acids. The pathologic central mechanism is the inhibition of cyclooxygenase, the disturbance of microcirculation and pro-apoptotic signaling. At all events, it is a theme for gastroenterologists to establish a mean to prevent the gastrointestinal ulcers induced by NSAIDs.
authors.affiliation: Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced*; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal