title: Platelet expression of CD62P in hypotrophic newborns.
abstract: BACKGROUND
  Hypotrophic newborns demonstrate a reduced blood platelet count and therefore may have haemostasis disorders. The antigen density of CD62P on the surface of platelets may indicate the activation of blood platelets.
  
  
  METHODS
  We have studied 31 hypotrophic newborns, and have divided these into two groups: weighing less than the 5th centile and between the 5th and 10th centiles. The antigen density of CD62P was calculated according to the procedure recommended by DAKO QIFIKIT.
  
  
  RESULTS
  Hypotrophic newborns exhibited a median 22 000 of CD62P per platelet. There is a distinct gender difference (female median 29 768, male median 19 044 of CD62P per platelet, p = 0.001). Newborns below the 5th centile demonstrated a median 30 000 of CD62P per platelet, whereas between the 5th and 10th centiles - a median 18 700. A negative correlation (R = -0.53, p = 0.002) was found between the antigen density of CD62P and birth weight.
  
  
  CONCLUSIONS
  Hypotrophy affects the expression of CD62P. There is a negative correlation between the antigen density of CD62P and birth weight.
authors.affiliation: Department of Neonatology, Medical University of Bialystok, Poland. awasiluk@umwb.edu.pl
authors.forename: Alicja
authors.initials: A
authors.lastname: Wasiluk
authors.forename: Maria
authors.initials: M
authors.lastname: Mantur
authors.forename: Halina
authors.initials: H
authors.lastname: Kemona
authors.forename: Robert
authors.initials: R
authors.lastname: Milewski
mesh_terms: D001724:Birth Weight; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D019007:P-Selectin / Q000096:biosynthesis* / Q000097:blood; D015539:Platelet Activation
chemical_list: D019007:P-Selectin