title: In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia.
abstract: The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50% inhibitory concentration value (IC(50)) of 0.3 μg/mL (1.1 μM) whereas psilostachyin showed activity on both strains (IC(50) = 0.6 (2.1 μM) and 1.8 μg/mL (6.4 μM)). Fifty percent cytotoxic concentration (CC(50)) values (48 h) were 6.8 μg/mL (24.3 μM) and 10.0 μg/mL (37.9 μM) for psilostachyin and peruvin, respectively.
authors.affiliation: Cátedra de Farmacognosia, IQUIMEFA (UBA-CONICET), Facultad de Farmacia y Bioquímica, UBA, Junín 956, Buenos Aires 1113, Argentina.
authors.forename: V
authors.initials: V
authors.lastname: Sülsen
authors.forename: D
authors.initials: D
authors.lastname: Gutierrez Yappu
authors.forename: L
authors.initials: L
authors.lastname: Laurella
authors.forename: C
authors.initials: C
authors.lastname: Anesini
authors.forename: A
authors.initials: A
authors.lastname: Gimenez Turba
authors.forename: V
authors.initials: V
authors.lastname: Martino
authors.forename: L
authors.initials: L
authors.lastname: Muschietti