title: Effect of smoking on the results of a chlorhexidine digluconate treatment extended up to 3 months after scaling and root planing-a pilot study.
abstract: The aim of the study was to evaluate the impact of smoking on a prolongated chlorhexidine digluconate regimen after scaling and root planing. Forty-two smokers (test group) and 85 nonsmoking patients (control group) with generalized chronic periodontitis were examined for clinical attachment level (CAL), probing depth (PD), bleeding on probing (BoP), and Plaque Index (Pl) at baseline and after 1 and 3 months. During scaling and root planing, a 0.2% chlorhexidine digluconate solution and a 1% chlorhexidine digluconate gel were used. The subjects used a 0.2% chlorhexidine digluconate solution twice daily for 3 months. The Mann-Whitney U and Wilcoxon tests were used for statistical analysis. There were significant improvements of all studied variables after 1 and 3 months in both groups. After 3 months, the mean improvement in the test group was 1.62 mm for CAL, 2.85 mm for PD, and 48% for BoP; in the control group, the values were 2.18 mm for CAL, 2.81 mm for PD, and 47% for BoP. Only the maximum changes of CAL between 1 and 3 months (test group, 0.32 mm vs 0.69 mm in the control group) and PD (test group, 0.47 mm vs 0.76 mm in the control group) were significantly different between the groups (P < .05 and P = .05, respectively). The present data appear to suggest that the use of chlorhexidine digluconate twice daily during a period of 3 months following nonsurgical periodontal therapy may result in significant clinical improvements in smokers and nonsmokers.
authors.affiliation: Department of Periodontology, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania. sbs@online.ro
authors.forename: Stefan-Ioan
authors.initials: SI
authors.lastname: Stratul
authors.forename: Anton
authors.initials: A
authors.lastname: Sculean
authors.forename: Darian
authors.initials: D
authors.lastname: Rusu
authors.forename: Andreea
authors.initials: A
authors.lastname: Didilescu
authors.forename: Adrian
authors.initials: A
authors.lastname: Kasaj
authors.forename: Holger
authors.initials: H
authors.lastname: Jentsch
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000009:adverse effects / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D055113:Chronic Periodontitis / Q000517:prevention & control / Q000628:therapy*; D003774:Dental Plaque Index; D012534:Dental Scaling; D005500:Follow-Up Studies; D005782:Gels; D005884:Gingival Hemorrhage / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use; D017622:Periodontal Attachment Loss / Q000517:prevention & control / Q000628:therapy; D010514:Periodontal Pocket / Q000517:prevention & control / Q000628:therapy; D010865:Pilot Projects; D011446:Prospective Studies; D016745:Root Planing; D012907:Smoking; D013651:Taste Disorders / Q000139:chemically induced; D014075:Tooth Discoloration / Q000139:chemically induced
chemical_list: D000891:Anti-Infective Agents, Local; D005782:Gels; D009067:Mouthwashes; C010882:chlorhexidine gluconate; D002710:Chlorhexidine