title: Neonatal systemic juvenile xanthogranuloma with an ominous presentation and successful treatment.
abstract: This case report originated from a case of neonatal multisystemic juvenile xanthogranuloma (JXG). The patient presented with blue muffin rush, cervical mass, bone destruction, lung nodule, hepatosplenomegaly, and coagulopathy and was successfully treated with Langerhans cell histiocytosis (LCH) based chemotherapy treatment. Similar cases in literature were reviewed and it seems that JXG, a relatively benign entity, when presented in its systemic form with liver involvement, could have an aggressive course and portend quite poor prognosis. Challenges and special consideration of the diagnosis, treatment, and future case observation are discussed.
authors.affiliation: Riley Hospital for Children at Indiana University Health Department of Pathology 702 Barnhill Drive, Room 2536 Indianapolis, Indiana, USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Fan
authors.forename: Jihong
authors.initials: J
authors.lastname: Sun