title: Intracellular trafficking of perforin: to thwart a killer.
abstract: How do killer cells restrain perforin, the most potent toxin known to biologists, at its point of synthesis in the endoplasmic reticulum, where conditions are ideal for its activation? In this issue of Immunity, Brennan et al. (2011) study its trafficking, offering insights into protective mechanisms.
authors.affiliation: NorthShore University HealthSystems Research Institute, Evanston, IL 60201, USA. cfroelich@uchicago.edu
authors.forename: Christopher
authors.initials: C
authors.lastname: Froelich
authors.forename: Sunil
authors.initials: S
authors.lastname: Metkar