title: Laser and intense pulsed light therapy for the treatment of hypertrophic scars: a systematic review.
abstract: Hypertrophic scars are difficult to improve and remain a therapeutic challenge. Several lasers and light sources have been evaluated in the past decades and have been shown to improve hypertrophic scars. However, a systematic review is not available. To assess current evidence of efficacy of all laser and intense pulsed light therapies used in the treatment of hypertrophic scars, we performed a systematic review searching electronic databases MEDLINE, EMBASE and CENTRAL. The quality of the controlled clinical trials was evaluated according to the Cochrane Collaboration's tool for assessing risk of bias. Thirteen articles involving seven different lasers met the inclusion criteria. Most evidence was found for the pulsed dye laser (PDL) 585 nm (eight studies), followed by the PDL 595 nm (two studies), whereas limited evidence (one trial per laser) was available for the fractional nonablative laser 1540 nm, CO₂ laser 10,600 nm, low-level laser therapy, Nd:YAG laser 532 nm and Erbium:YAG laser 2940 nm. Treatment recommendations should be formulated with caution as current evidence is insufficient for comparing the efficacy of different laser therapies. The PDL 585 nm showed a low efficacy for the treatment of hypertrophic scars. With moderate efficacy, the PDL 595 nm is promising, although more research is necessary. Little evidence was found for the efficacy of other lasers. Future research, with a low risk of bias, well-defined scar characteristics, validated outcome measures, standardized measurement methods, follow-up periods of at least 6 months and well-defined laser settings, is needed.
authors.affiliation: Netherlands Institute for Pigment Disorders (SNIP), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands c.vrijman@amc.uva.nl
authors.forename: C
authors.initials: C
authors.lastname: Vrijman
authors.forename: A M
authors.initials: AM
authors.lastname: van Drooge
authors.forename: J
authors.initials: J
authors.lastname: Limpens
authors.forename: J D
authors.initials: JD
authors.lastname: Bos
authors.forename: J P W
authors.initials: JP
authors.lastname: van der Veen
authors.forename: P I
authors.initials: PI
authors.lastname: Spuls
authors.forename: A
authors.initials: A
authors.lastname: Wolkerstorfer
mesh_terms: D000328:Adult; D017439:Cicatrix, Hypertrophic / Q000628:therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010789:Phototherapy / Q000379:methods*; D017594:Publication Bias