title: Volumetric analysis of the African elephant ventricular system.
abstract: This study used magnetic resonance imaging (MRI) to determine the volume of the ventricular system in the brain of three adult male African elephants (Loxodonta africana). The ventricular system of the elephant has a volume of ∼240 mL, an order of magnitude larger than that seen in the adult human. Despite this large size, allometric analysis indicates that the volume of the ventricles in the elephant is what one would expect for a mammal with an ∼5 kg brain. Interestingly, our comparison with other mammals revealed that primates appear to have small relative ventricular volumes, and that megachiropterans and microchiropterans follow different scaling rules when comparing ventricular volume to brain mass indicating separate phylogenetic histories. The current study provides context for one aspect of the elephant brain in the broader picture of mammalian brain evolution.
authors.affiliation: School of Anatomical Science, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Republic of South Africa.
authors.forename: Busisiwe C
authors.initials: BC
authors.lastname: Maskeo
authors.forename: Muhammed A
authors.initials: MA
authors.lastname: Spocter
authors.forename: Mark
authors.initials: M
authors.lastname: Haagensen
authors.forename: Paul R
authors.initials: PR
authors.lastname: Manger
mesh_terms: D000367:Age Factors; D000818:Animals; D000886:Anthropometry / Q000379:methods; D005075:Biological Evolution; D002552:Cerebral Ventricles / Q000033:anatomy & histology*; D002685:Chiroptera / Q000033:anatomy & histology; D004606:Elephants / Q000033:anatomy & histology*; D007312:Eulipotyphla / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D010802:Phylogeny; D011323:Primates / Q000033:anatomy & histology