title: [A case of Pneumocystis jirovecii pneumonia after kidney transplantation with re-exacerbation following therapy].
abstract: A 55-year-old man who had a living kidney transplant 3 months previously was admitted complaining of 4 days of non-productive cough and fever. Because of his low oxygen saturation (SpO2 83% on room air), ground-glass opacities in both lung fields, and marked elevation of beta-D-glucan, a diagnosis of Pneumocystis jirovecii pneumonia (PCP) was considered. The diagnosis of PCP was confirmed by bronchoalveolar lavage. Subsequently, his oxygenation level decreased even after the administration of trimethoprim-sulfamethoxazole, therefore we concurrently administered 60 mg of prednisolone. His clinical symptoms and radiographic findings gradually improved. However, his respiratory condition and radiographic findings exacerbated again after the tapering of prednisolone. His condition improved after the prednisolone dose was returned to 30 mg per day. This case suggested that, in the treatment of PCP in patients without human immunodeficiency virus (HIV) infection, reduction of steroids may cause exacerbation of PCP, similar to immune reconstitution inflammatory syndrome which occurs in HIV patients.
authors.affiliation: Department of Infections, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus.
authors.forename: Jun
authors.initials: J
authors.lastname: Hirai
authors.forename: Shusaku
authors.initials: S
authors.lastname: Haranaga
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Teruya
authors.forename: Satomi
authors.initials: S
authors.lastname: Yara
authors.forename: Futoshi
authors.initials: F
authors.lastname: Higa
authors.forename: Jiro
authors.initials: J
authors.lastname: Fujita
mesh_terms: D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D045363:Pneumocystis carinii; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D011183:Postoperative Complications; D011239:Prednisolone / Q000008:administration & dosage
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone