title: Bridging global gene expression candidates in first trimester placentas with susceptibility loci from linkage studies of preeclampsia.
abstract: Preeclampsia is as a leading cause of maternal and perinatal morbidity and mortality. Prevention, early identification, and individualized treatments may become feasible if reliable early biomarkers can be developed. Towards a systems biology framework, this review synthesizes prior linkage studies and genome scans of preeclampsia with candidates identified in a global gene expression microarray analysis of chorionic villus sampling (CVS) specimens from women who subsequently developed preeclampsia. Nearly 40% of these CVS candidate genes occurred in previously identified susceptibility loci for preeclampsia. Integration of genetic epidemiologic and functional gene expression data could help to elucidate preeclampsia as a complex disease resulting from multiple maternal and fetal/placental factors that each contributes a greater or lesser effect. These loci and related candidate genes are set to substantially improve insights into the first trimester pathogenesis of this pregnancy disorder.
authors.affiliation: Department of Health Promotion and Development, School of Nursing, Member, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA. foundss@pitt.edu
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Founds
mesh_terms: D015193:Chorionic Villi Sampling; D002874:Chromosome Mapping; D005260:Female; D015870:Gene Expression; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D049490:Systems Biology