title: Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population.
abstract: BACKGROUND
  Although familial clustering of functional dyspepsia (FD) has been reported, the role of genetics in the susceptibility to FD is still not well understood. In the present study, the association between serotonin transporter (SERT) gene (SLC6A4) polymorphism and FD was explored.
  
  
  METHODS
  Subjects were divided into either a postprandial distress syndrome (PDS) group or an epigastric pain syndrome (EPS) group according to the Rome III criteria. The healthy controls were those who had visited a hospital for an annual health check-up. The presence of the SLC6A4 promoter polymorphism, 5-hydroxytryptamin transporter gene linked polymorphic region (5-HTTLPR), was then evaluated, and logistic regression analysis was used to test all variables.
  
  
  RESULTS
  The 5-HTTLPR genotype distribution was 448 SS, 174 SL, and 24 LL in controls and 30 SS, 20 SL, and 3 LL in FD subjects. No significant correlation was found between the 5-HTTLPR genotype and FD. When the genotypes and subtypes of FD were exploratory evaluated, the SL genotype was significantly associated with PDS [odds ratio (OR) = 2.24, 95% confidence interval (CI); 1.16-4.32, P = 0.034 after Bonferroni correction] compared to the SS genotype adjusted for sex and age. Comparison of the SS genotype with the SL/LL genotype also showed a significant association of genotype with PDS (OR = 2.32, 95% CI; 1.23-4.37, P = 0.009).
  
  
  CONCLUSIONS
  The present results suggest that 5-HTTLPR L allele may influence the susceptibility to PDS.
authors.affiliation: Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Toyoshima
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Oshima
authors.forename: Shigemi
authors.initials: S
authors.lastname: Nakajima
authors.forename: Jun
authors.initials: J
authors.lastname: Sakurai
authors.forename: Junji
authors.initials: J
authors.lastname: Tanaka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Tomita
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Hori
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Hiroto
authors.initials: H
authors.lastname: Miwa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016000:Cluster Analysis; D004415:Dyspepsia / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D019518:Postprandial Period; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins