title: Targeting serotonin synthesis to treat irritable bowel syndrome.
authors.forename: Jan
authors.initials: J
authors.lastname: Tack
authors.forename: Pieter
authors.initials: P
authors.lastname: Janssen
authors.forename: Mira
authors.initials: M
authors.lastname: Wouters
authors.forename: Guy
authors.initials: G
authors.lastname: Boeckxstaens
mesh_terms: D001713:Biphenyl Compounds / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D043183:Irritable Bowel Syndrome / Q000188:drug therapy*; D008297:Male; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012701:Serotonin / Q000096:biosynthesis*; D014365:Tryptophan Hydroxylase / Q000037:antagonists & inhibitors*
chemical_list: C557875:2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)-pyrimidin-4-yl)phenyl)propionic acid; D001713:Biphenyl Compounds; D012701:Serotonin; D010649:Phenylalanine; D006897:Hydroxyindoleacetic Acid; D014365:Tryptophan Hydroxylase