title: Increased syphilis trend among patients in an AIDS information and prevention center.
abstract: OBJECTIVE
  A rebound of syphilis cases has recently been observed. This study describes the trend in syphilis infection among persons attending the AIDS information and prevention center of Valencia, Spain.
  
  
  METHODS
  We performed a cohort study of all persons attended from 2000 to 2006. The calendar effect was assessed by a logistic regression model adjusted by sexual and sociodemographic variables.
  
  
  RESULTS
  A total of 71% were heterosexuals (HT) and 19% were men who had sex with men (MSM). Among the 10,850 users of the center, the prevalence of syphilis was 0.7%. Among MSM, the prevalence of syphilis was 2.4% for the whole period and was 4.6% for 2006. Multivariate analysis showed that the risk of infection was lower in persons with a university education (OR=0.10; 95%CI: 0.03-0.59) than in those without. The risk was higher in persons who took drugs (OR=5.49; 95%CI: 1.55-19.43) or who practiced prostitution (OR=6.83; 95%CI: 2.52-18.53). In 2006, the risk of having syphilis was greater (OR=5.05; 95%CI: 1.12-22.72).
  
  
  CONCLUSIONS
  Syphilis infection increased substantially among MSM. In this collective, the prevalence of infection is related to educational level, prostitution and the use of non-injected recreational drugs.
authors.affiliation: The Biomedical Research Center Network for Epidemiology and Public Health, Spain. hurtado isa@gva.es
authors.forename: Isabel
authors.initials: I
authors.lastname: Hurtado
authors.forename: Ignacio
authors.initials: I
authors.lastname: Alastrue
authors.forename: Menelaos
authors.initials: M
authors.lastname: Pavlou
authors.forename: Teresa
authors.initials: T
authors.lastname: Tasa
authors.forename: Santiago
authors.initials: S
authors.lastname: Pérez-Hoyos
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D001727:Bisexuality / Q000706:statistics & numerical data; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D018451:Homosexuality, Male / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007253:Information Centers / Q000706:statistics & numerical data*; D008297:Male; D009017:Morbidity / Q000639:trends; D010353:Patient Education as Topic; D015995:Prevalence; D012309:Risk-Taking; D011477:Sex Work / Q000706:statistics & numerical data; D013030:Spain / Q000453:epidemiology; D019966:Substance-Related Disorders / Q000453:epidemiology; D013587:Syphilis / Q000453:epidemiology* / Q000635:transmission