title: Exanthema medicamentosum as a side effect of promazine.
abstract: Dermatological side effects of psychopharmacological drugs are fortunately not so often. They are mostly presented in the group of mood stabilizers and antiepileptic drugs, particularly the carbamazepine and lamotrigine, and can be manifested through the Stevens Johnson syndrome, Toxic Epidermal Necrolysis (TEN)/Lyell's syndrome with about 30% lethality. According to the literature the group of phenothiazines is the category of drugs with rare appearances of skin reactions. Promazine, aliphatic phenothiazines antipsychotic, including less frequent side effects in the leaflet states increased skin sensitivity to sun, skin rash-associated with contact dermatitis, allergic reactions, cholestatic icterus. The only reported dermatological side effect of promazine is its metabolites deposition in the cornea. Analyzing the e-data basis we have not found references connecting the Exanthema medicamentosum as a side effect of promazine. A forty-two years old female patient was admitted to the Dermatological Clinic because of suspected exanthema, undoubtedly caused by promazine as a medication for Sy. Borderline.
authors.affiliation: University Psychiatric Clinic, Clinical Hospital Centre Split, Spinčićeva 1, 21000 Split, Croatia. dlasic@kbsplit.hr
authors.forename: Davor
authors.initials: D
authors.lastname: Lasić
authors.forename: Marija Zuljan
authors.initials: MZ
authors.lastname: Cvitanović
authors.forename: Boran
authors.initials: B
authors.lastname: Uglešić
authors.forename: Vitomir
authors.initials: V
authors.lastname: Višić
authors.forename: Ivana
authors.initials: I
authors.lastname: Hlevnjak
mesh_terms: D000328:Adult; D000525:Alprazolam / Q000008:administration & dosage; D018926:Anti-Allergic Agents / Q000008:administration & dosage; D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001623:Betamethasone / Q000008:administration & dosage; D017332:Cetirizine / Q000008:administration & dosage; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D003879:Dermatologic Agents / Q000008:administration & dosage; D005076:Exanthema / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage; D010554:Personality Disorders / Q000188:drug therapy; D011395:Promazine / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D014151:Anti-Anxiety Agents; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D014150:Antipsychotic Agents; D003879:Dermatologic Agents; D005839:Gentamicins; D001623:Betamethasone; C010882:chlorhexidine gluconate; D011395:Promazine; D002710:Chlorhexidine; D008775:Methylprednisolone; D017332:Cetirizine; D000525:Alprazolam