title: Different recovery responses from dietary zinc-deficiency in the distribution of rat granulocytes.
abstract: The purpose of this study was to elucidate the effects of the recovery from dietary zinc-deficiency on the number of total white blood cells (WBCs), neutrophils, eosinophils and basophils, and plasma zinc and corticosterone concentrations in weanling male Sprague Dawley rats. Rats (n=34) of the zinc-deficient diet (0.6 mg zinc/kg diet) and control diet (35.2 mg zinc/kg diet) groups were fed for 4 wk, and then rats of both groups were fed with the control diet for 3 wk. Zinc-deficiency increased duration-dependently and clearly the number of total WBCs, neutrophils and eosinophils, and the increased numbers of these cells recovered to the control levels in week 2 of the recovery. On the other hand, the number of basophils increased by the zinc-deficiency recovered to the control levels in week 1 of the recovery. Zinc-deficiency significantly decreased plasma zinc concentrations by 85%, and markedly increased plasma corticosterone concentrations by 317%, as compared with the control group. In the recovery period, plasma zinc and corticosterone concentrations recovered to the control levels in week 2 of the recovery. These results suggest that zinc-deficiency and its recovery responses in the number of granulocytes and total WBCs are reversible, and their recovery rates depend on the subsets of granulocytes in rats.
authors.affiliation: Laboratory of Physiological Sciences, Graduate School of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sakakibara
authors.forename: Shogo
authors.initials: S
authors.lastname: Sato
authors.forename: Yu
authors.initials: Y
authors.lastname: Kawashima
authors.forename: Yui
authors.initials: Y
authors.lastname: Someya
authors.forename: Ken
authors.initials: K
authors.lastname: Shirato
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tachiyashiki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Imaizumi
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood*; D003677:Deficiency Diseases / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D004032:Diet; D006098:Granulocytes / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015032:Zinc / Q000097:blood / Q000172:deficiency* / Q000627:therapeutic use
chemical_list: D015032:Zinc; D003345:Corticosterone