title: The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms.
abstract: The ketogenic diet (KD) is a treatment of infantile spasms (IS). Here, we examine the efficacy of KD in medically refractory IS, examine its impact on growth in infants, and explore its mechanism of action. At 1-3 months after the initiation of the KD, 46% of twenty-six patients had a greater than 90% reduction in IS. No significant relationships between reduction in IS and serum β-hydroxybutyrate, or glucose levels were identified. Also, the KD had not significantly altered patient's growth parameters. Thus, in corroborating with prior studies, we demonstrate the KD is a well-tolerated and efficacious treatment of IS.
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Adam L
authors.initials: AL
authors.lastname: Numis
authors.forename: Margaret B
authors.initials: MB
authors.lastname: Yellen
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Chu-Shore
authors.forename: Heidi H
authors.initials: HH
authors.lastname: Pfeifer
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Thiele
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000378:metabolism; D000886:Anthropometry; D001786:Blood Glucose; D001827:Body Height / Q000502:physiology*; D001835:Body Weight / Q000502:physiology*; D015331:Cohort Studies; D055423:Diet, Ketogenic / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000178:diet therapy / Q000209:etiology; D013036:Spasms, Infantile / Q000150:complications / Q000178:diet therapy* / Q000209:etiology
chemical_list: D001786:Blood Glucose; D020155:3-Hydroxybutyric Acid