title: [A case of pulmonary toxocariasis successfully treated with ivermectin].
abstract: A 36-year-old man who often ate raw chicken meat had abnormal chest radiograph findings on a health check-up in July 2009, and visited our department. A chest computed tomographic scan revealed 6 nodular shadows in both lungs, and a hematologic examination revealed eosinophilia and elevation of IgE. Because of his history of eating raw chicken meat, antiparasite antibody testing was performed which revealed antibodies to Toxocara canis, leading to the diagnosis of pulmonary toxocariasis due to Toxocara canis. Although treatment with albendazole was performed, it was discontinued because of hepatic impairment. However, hematological examination showed that his eosinophil count and IgE increased again, and chest image findings were exacerbated. Therefore, ivermectin, reported as effective in cases outside Japan, was administered, resulting in decreased peripheral eosinophils, normalized IgE level, and disappearance of the shadows on chest images. In Japan, no cases of pulmonary toxocariasis responding well to ivermectin have previously been reported. Administration of ivermectin should be considered when albendazol cannot be used due to hepatic impairment or related problems.
authors.affiliation: Department of Respiratory Medicine, Minami Kyushu National Hospital.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujii
authors.forename: Hiroko
authors.initials: H
authors.lastname: Mataki
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Koreeda
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kawabata
authors.forename: Minako
authors.initials: M
authors.lastname: Hamada
authors.forename: Jirou
authors.initials: J
authors.lastname: Nakashioya
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Tomiyama
authors.forename: Masaharu
authors.initials: M
authors.lastname: Kawabata
mesh_terms: D000328:Adult; D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use*; D008174:Lung Diseases, Parasitic / Q000188:drug therapy*; D008297:Male; D017166:Toxocara canis; D014120:Toxocariasis / Q000188:drug therapy*
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin