title: CASP8AP2 is a promising prognostic indicator in pediatric acute lymphoblastic leukemia.
abstract: The prognostic significance of caspase 8 associated protein 2 (CASP8AP2) in pediatric ALL is controversial. We determined a cut-off of CASP8AP2 expression in bone marrow samples of 39 newly diagnosed patients, and found a significantly poor bone marrow relapse-free survival (p=0.019) in low-expression group and verified it in another cohort of 106 patients (p=0.002). Furthermore, as an independent prognostic factor, CASP8AP2 expression was correlated to minimal residual disease (MRD), and incorporating it with MRD would help to identify patients at greater risk of bone marrow relapse. We also developed an algorithm comprised of clinical risk and CASP8AP2 expression, which could predict bone marrow relapse more accurately.
authors.affiliation: Key Laboratory of Major Diseases in Children, Ministry of Education & National Key Discipline of Pediatrics, Ministry of Education & Department of Hematology, Beijing Children's Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiao
authors.forename: Lei
authors.initials: L
authors.lastname: Cui
authors.forename: Chao
authors.initials: C
authors.lastname: Gao
authors.forename: Weijing
authors.initials: W
authors.lastname: Li
authors.forename: Xiaoxi
authors.initials: X
authors.lastname: Zhao
authors.forename: Shuguang
authors.initials: S
authors.lastname: Liu
authors.forename: Minyuan
authors.initials: M
authors.lastname: Wu
authors.forename: Guoren
authors.initials: G
authors.lastname: Deng
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Li
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000502:physiology*; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D015973:Gene Expression Regulation, Leukemic / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D018365:Neoplasm, Residual; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D011379:Prognosis; D012008:Recurrence
chemical_list: D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor; C485604:CASP8AP2 protein, human; D002135:Calcium-Binding Proteins