title: Nevirapine nanosuspensions for HIV reservoir targeting.
abstract: In this paper we discuss, production, characterization and in-vivo evaluation of nevirapine nanosuspensions. Laser diffraction showed that the average particles size was 457 nm. Following single-dose administration, the plasma gamma concentration profiles showed fast release. Macrophage uptake studies confirmed enhanced cellular uptake for nanonized nevirapine with no added cytotoxicity. Gamma scintigraphy showed that the nanosuspension prepared can be used to target spleen, thymus and lungs, which represent anatomical viral reservoirs. Thus nevirapine nanosuspensions with targeting potential have been prepared successfully.
authors.affiliation: C.U. Shah College of Pharmacy, S.N.D.T. Women's University, Santacruz(W), Mumbai, India.
authors.forename: R
authors.initials: R
authors.lastname: Shegokar
authors.forename: K K
authors.initials: KK
authors.lastname: Singh
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002614:Chelating Agents / Q000737:chemistry; D004396:Coloring Agents; D004197:Disease Reservoirs / Q000821:virology*; D004563:Electrochemistry; D015497:HIV-1 / Q000187:drug effects*; D066298:In Vitro Techniques; D007263:Infusions, Parenteral; D007553:Isotope Labeling; D007668:Kidney / Q000000981:diagnostic imaging; D008264:Macrophages / Q000378:metabolism; D008297:Male; D051379:Mice; D018625:Microscopy, Atomic Force; D053758:Nanoparticles; D019829:Nevirapine / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D010316:Particle Size; D010539:Permeability; D011877:Radionuclide Imaging; D051381:Rats; D012995:Solubility; D013535:Suspensions; D013778:Tetrazolium Salts; D013844:Thiazoles; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000000981:diagnostic imaging; D014961:X-Ray Diffraction
chemical_list: D019380:Anti-HIV Agents; D002614:Chelating Agents; D004396:Coloring Agents; D013535:Suspensions; D013778:Tetrazolium Salts; D013844:Thiazoles; D019829:Nevirapine; C022616:thiazolyl blue