title: Contemporary strategies for peptide macrocyclization.
abstract: Peptide macrocycles have found applications that range from drug discovery to nanomaterials. These ring-shaped molecules have shown remarkable capacity for functional fine-tuning. Such capacity is enabled by the possibility of adjusting the peptide conformation using the techniques of chemical synthesis. Cyclic peptides have been difficult, and often impossible, to prepare using traditional synthetic methods. For macrocyclization to occur, the activated peptide must adopt an entropically disfavoured pre-cyclization conformation before forming the desired product. Here, we review recent solutions to some of the major challenges in this important area of contemporary synthesis.
authors.affiliation: University of Toronto, Chemistry, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: White
authors.forename: Andrei K
authors.initials: AK
authors.lastname: Yudin
mesh_terms: D008968:Molecular Conformation; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010455:Peptides; D010456:Peptides, Cyclic