title: Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole.
abstract: Clotrimazole and bifonazole are highly effective antifungal agents against mucosal Candida albicans infections. Here we examined the effects of low levels of clotrimazole and bifonazole on the ability of C. albicans to adhere, invade, and damage vaginal epithelial cells. Although adhesion and invasion were not affected, damage was greatly reduced upon azole treatment. This clearly indicates that low levels of azoles influence specific activities of C. albicans during distinct stages of vaginal epithelium infections.
authors: Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute Jena (HKI), Beutenbergstraße 11a, D-07745 Jena, Germany.
authors: Betty
authors: B
authors: Wächtler
authors: Duncan
authors: D
authors: Wilson
authors: Bernhard
authors: B
authors: Hube
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000502:physiology*; D002460:Cell Line; D003022:Clotrimazole / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D004847:Epithelial Cells / Q000382:microbiology*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D014621:Vagina / Q000166:cytology*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D003022:Clotrimazole; C036596:bifonazole