title: Application of magnetic nanoparticles to gene delivery.
abstract: Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as well as clinical diagnostic and therapeutic applications. For example, nanoparticles hold great promise for enabling gene therapy to reach its full potential by facilitating targeted delivery of DNA into tissues and cells. Substantial progress has been made in binding DNA to nanoparticles and controlling the behavior of these complexes. In this article, we review research on binding DNAs to nanoparticles as well as our latest study on non-viral gene delivery using polyethylenimine-coated magnetic nanoparticles.
authors: Research Team for Vascular Medicine, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan; E-Mails: yitakura@tmig.or.jp (Y.I.); satoshigojo-tky@umin.ac.jp (S.G.); mtoyoda@tmig.or.jp (M.T.).
authors: Daisuke
authors: D
authors: Kami
authors: Shogo
authors: S
authors: Takeda
authors: Yoko
authors: Y
authors: Itakura
authors: Satoshi
authors: S
authors: Gojo
authors: Masatoshi
authors: M
authors: Watanabe
authors: Masashi
authors: M
authors: Toyoda
mesh_terms: D017690:Cell Transplantation; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D018014:Gene Transfer Techniques / Q000295:instrumentation*; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D011094:Polyethyleneimine / Q000737:chemistry
chemical_list: D058185:Magnetite Nanoparticles; D011094:Polyethyleneimine; D004247:DNA