title: Corpus callosum and experimental stroke: studies in callosotomized rats and acallosal mice.
abstract: OBJECTIVE
  Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke.
  
  
  METHODS
  We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice.
  
  
  RESULTS
  Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion.
  
  
  CONCLUSIONS
  These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.
authors: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
authors: Kunlin
authors: K
authors: Jin
authors: Lin
authors: L
authors: Xie
authors: Fen
authors: F
authors: Sun
authors: Xiaoou
authors: X
authors: Mao
authors: David A
authors: DA
authors: Greenberg
mesh_terms: D000818:Animals; D020520:Brain Infarction / Q000473:pathology* / Q000503:physiopathology*; D003337:Corpus Callosum / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D004195:Disease Models, Animal; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D020521:Stroke / Q000473:pathology* / Q000503:physiopathology*