title: Effect of fast dietary proteins on muscle protein synthesis rate and muscle strength in ad libitum-fed and energy-restricted old rats.
abstract: Sarcopenia is defined as age-related loss of muscle mass and strength. Energy restriction (ER) delays fibre loss by limiting the accumulated deleterious effects of reactive oxygen species on muscle. However, insufficient protein intake during ER might affect muscle mass and function. We hypothesised that ingestion of fast-digested proteins such as whey protein (WP) improves muscle protein synthesis and muscle strength in aged ER rats. The effect of WP or casein (CAS, slow protein) on muscle mass, protein synthesis and strength was evaluated in 21-month-old rats fed for 5 months either ad libitum (AL) or a 40 % protein and energy-restricted (PER) or 40 % AL-isonitrogenous ER diet. The nitrogen balance was reduced in PER-CAS rats only ( - 48 % v. AL-CAS). WP stimulated muscle protein synthesis rates compared with CAS in all groups (+21,+37 and +34 % in AL, PER and ER conditions, respectively). Muscle strength was higher in ER rats than in AL rats (+23 and +12 % for WP or CAS, respectively). Muscle performance tended to be greater in ER rats fed WP than in ER-CAS rats (P < 0·09). In conclusion, we observed that long-term ER combined with maintained protein intake had a beneficial impact on muscle protein synthesis rate and function during ageing.
authors: INRA, UMR, Unité de Nutrition Humaine, Clermont-Ferrand, France. swalrand@clermont.inra.fr
authors: Stéphane
authors: S
authors: Walrand
authors: Aude
authors: A
authors: Zangarelli
authors: Christelle
authors: C
authors: Guillet
authors: Jérôme
authors: J
authors: Salles
authors: Karine
authors: K
authors: Soulier
authors: Christophe
authors: C
authors: Giraudet
authors: Véronique
authors: V
authors: Patrac
authors: Yves
authors: Y
authors: Boirie
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000494:pharmacology; D002149:Energy Intake; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis*; D053580:Muscle Strength / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004044:Dietary Proteins; D009124:Muscle Proteins