title: Mannan-binding lectin-2 (MBL2) gene polymorphisms in prenatal and perinatal cytomegalovirus infections.
abstract: Cytomegalovirus (CMV) is the leading cause of congenital infections among neonates. About 10% of newborns with such an infection have clinical symptoms at birth and about 1% of infected fetuses die due to developmental malformations. Mannan-binding lectin (MBL) is considered to be an important factor in innate immunity. Its deficiency is believed to predispose to various (including viral) infections. The aim of this study was to investigate the possible role of MBL2 gene polymorphisms in prenatal and perinatal CMV infections. The frequencies of MBL2 gene exon 1 mutations as well as MBL deficiency-associated variants (LXPA/O+O/O) among newborns with confirmed cytomegalovirus infection were not significantly lower than among non-infected individuals. The distribution of MBL2 haplotypes was similar between the groups studied. These data suggest MBL does not have a major influence on susceptibility to prenatal or perinatal CMV infections.
authors: Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland.
authors: Agnieszka
authors: A
authors: Szala
authors: Edyta
authors: E
authors: Paradowska
authors: Dorota
authors: D
authors: Nowakowska
authors: Anna S
authors: AS
authors: Swierzko
authors: Katarzyna
authors: K
authors: Dzierzanowska-Fangrat
authors: Anna
authors: A
authors: Sokolowska
authors: Miroslawa
authors: M
authors: Studzinska
authors: Zuzanna
authors: Z
authors: Gaj
authors: Patrycja
authors: P
authors: Suski
authors: Beata
authors: B
authors: Kasztelewicz
authors: Jan
authors: J
authors: Wilczynski
authors: Maciej
authors: M
authors: Cedzynski
mesh_terms: D003586:Cytomegalovirus Infections / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D037601:Mannose-Binding Lectin / Q000172:deficiency / Q000235:genetics*; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin