title: The biology of interleukin-1: emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics.
abstract: Interleukin (IL)-1 is a proinflammatory cytokine with important roles in innate immunity, as well as in normal tissue homeostasis. Interestingly, recent studies have also shown IL-1 to function in the dynamics of the actin cytoskeleton and cell junctions. For example, treatment of different epithelia with IL-1α often results in the restructuring of the actin network and cell junctions, thereby leading to junction disassembly. In this review, we highlight new and interesting findings that show IL-1 to be a critical player of restructuring events in the seminiferous epithelium of the testis during spermatogenesis.
authors: Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, USA.
authors: Pearl P Y
authors: PP
authors: Lie
authors: C Yan
authors: CY
authors: Cheng
authors: Dolores D
authors: DD
authors: Mruk
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism*; D007375:Interleukin-1 / Q000378:metabolism* / Q000502:physiology; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction; D013091:Spermatogenesis; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D016328:NF-kappa B; D020741:rho GTP-Binding Proteins