title: Hypolipidemic potential of flowers of Nerium oleander in high fat diet-fed Sprague Dawley rats.
abstract: Nerium oleander Linn. (NO), an evergreen shrub, is used in folklore medicine as a cardiotonic and exhibits a wide spectrum of bioactivities. Herein, the hypolipidemic potential of the ethanolic extract of flowers of Nerium oleander (ENO) in a minimal dose was assessed. A high fat diet (HFD) resulted in a significant increase in cardiac lipids and lipoproteins and an increase in body weight gain. Simultaneous treatment with ENO significantly lowered the increase in body weight gain, lipid and lipoprotein levels, with a concomitant increase in HDL in the plasma and heart when compared to HFD-fed rats. Likewise, the activities of lipolytic enzymes were also upheld by the ENO treatment in the heart compared to HFD-fed rats. The above findings highlight the possible mechanism of N. oleander as a hypolipidemic agent in its use in folklore medicine as a cardiotonic.
authors: Herbal and Indian Medicine Research Laboratory, Department of Biochemistry, Sri Ramachandra University, Porur, Chennai 600116, India.
authors: Veeraraghavan
authors: V
authors: Gayathri
authors: Subhash
authors: S
authors: Ananthi
authors: Chandranayagam
authors: C
authors: Chandronitha
authors: Marimuthu Kannan
authors: MK
authors: Sangeetha
authors: Hannah R
authors: HR
authors: Vasanthi
mesh_terms: D000818:Animals; D000069059:Atorvastatin; D004041:Dietary Fats / Q000009:adverse effects*; D035264:Flowers / Q000737:chemistry*; D006538:Heptanoic Acids / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008074:Lipoproteins / Q000378:metabolism; D030007:Nerium / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects
chemical_list: D004041:Dietary Fats; D006538:Heptanoic Acids; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D010936:Plant Extracts; D011758:Pyrroles; D000069059:Atorvastatin