title: Assessment of the cardiotoxicity of tulathromycin in rabbits.
abstract: The aim of this study was to determine the cardiotoxic potency of tulathromycin. Tulathromycin (10 mg/kg, SC) was administered to ten adult male rabbits, and blood samples were obtained before and after drug administration (0 and 6 hours). Serum cardiac damage markers (troponin I, creatine kinase-MB, myoglobin, lactate dehydrogenase, aspartate aminotransferase), routine serum biochemical values (alkaline phosphatase, alanine aminotransferase, gamma-glutamyltransferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high-density lipoprotein, amylase, total protein, albumin, glucose, calcium, ionised calcium, sodium, potassium), white blood cell (WBC) and red blood cell (RBC) counts, arterial blood gas parameters (pH, partial carbon dioxide pressure, partial oxygen pressure, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, packed cell volume, haemoglobin) and serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol, β-carotene) were measured. Increased levels of troponin I, creatine kinase-MB and creatinine, and decreased WBC counts, ionised calcium and potassium levels were observed after drug administration. Tulathromycin treatment may cause cardiotoxicity, but its effects may be less dramatic than those of other macrolide antibiotics frequently used in veterinary medicine.
authors: University of Selcuk Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Konya Turkey. eyazar@selcuk.edu.tr
authors: Ayse
authors: A
authors: Er
authors: Feray
authors: F
authors: Altan
authors: Gul
authors: G
authors: Cetin
authors: Burak
authors: B
authors: Dik
authors: Muammer
authors: M
authors: Elmas
authors: Enver
authors: E
authors: Yazar
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D004187:Disaccharides / Q000009:adverse effects*; D006331:Heart Diseases / Q000139:chemically induced / Q000662:veterinary*; D006571:Heterocyclic Compounds / Q000009:adverse effects*; D007958:Leukocyte Count; D008297:Male; D011188:Potassium / Q000097:blood; D011817:Rabbits; D019210:Troponin I / Q000097:blood; D018942:Macrolides
chemical_list: D000900:Anti-Bacterial Agents; D002118:Calcium; D003404:Creatinine; D004187:Disaccharides; D006571:Heterocyclic Compounds; D011188:Potassium; D019210:Troponin I; C485204:tulathromycin; D018942:Macrolides