title: Pharmacokinetics and ex vivo antimalarial activity of artesunate-azithromycin in healthy volunteers.
abstract: In 18 male healthy subjects, artesunate (200 mg)-azithromycin (1,500 mg) daily for 3 days was found to be well tolerated, with only mild gastrointestinal disturbances reported. The pharmacokinetic properties of artesunate-azithromycin given in combination are comparable to those of the drugs given alone. Artesunate and its major active metabolite, dihydroartemisinin, are responsible for most of the ex vivo antimalarial activity, with a delayed contribution by azithromycin.
authors: Department of Infectious Diseases, Military Hospital 108, Hanoi, Vietnam.
authors: Nguyen Trong
authors: NT
authors: Chinh
authors: Nguyen Ngoc
authors: NN
authors: Quang
authors: Chu Xuan
authors: CX
authors: Anh
authors: Nguyen Xuan
authors: NX
authors: Thanh
authors: Bui
authors: B
authors: Dai
authors: Geoffrey W
authors: GW
authors: Birrell
authors: Marina
authors: M
authors: Chavchich
authors: Michael D
authors: MD
authors: Edstein
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000493:pharmacokinetics* / Q000627:therapeutic use; D037621:Artemisinins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000077332:Artesunate; D017963:Azithromycin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002853:Chromatography, Liquid; D004338:Drug Combinations; D006801:Humans; D008297:Male; D053719:Tandem Mass Spectrometry; D055815:Young Adult
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004338:Drug Combinations; D000077332:Artesunate; D017963:Azithromycin