title: Recombinant cytokines from plants.
abstract: Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.
authors: Institute of Biochemistry and Biophysics Polish Academy of Sciences, ul. Pawinskiego 5a, 02-106 Warsaw, Poland; E-Mails: annag@ibb.waw.pl (A.G.-S.); PatiRed@ibb.waw.pl (P.R.).
authors: Agnieszka
authors: A
authors: Sirko
authors: Tomas
authors: T
authors: Vaněk
authors: Anna
authors: A
authors: Góra-Sochacka
authors: Patrycja
authors: P
authors: Redkiewicz
mesh_terms: D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010944:Plants / Q000378:metabolism*; D030821:Plants, Genetically Modified / Q000378:metabolism; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D016207:Cytokines; D011994:Recombinant Proteins