title: The acute toxicity and hematological characterization of the effects of tentacle-only extract from the jellyfish Cyanea capillata.
abstract: To investigate the hematologic changes and the activities of jellyfish venoms other than hemolytic and cardiovascular toxicities, the acute toxicity of tentacle-only extract (TOE) from the jellyfish Cyanea capillata was observed in mice, and hematological indexes were examined in rats. The median lethal dose (LD(50)) of TOE was 4.25 mg/kg, and the acute toxicity involved both heart- and nervous system-related symptoms. Arterial blood gas indexes, including pH, PCO(2), HCO(3) (-), HCO(3)std, TCO(2), BEecf and BE (B), decreased significantly. PO(2) showed a slight increase, while SO(2)c (%) had no change at any time. Na(+) and Ca(2+) decreased, but K(+) increased. Biochemical indexes, including LDH, CK, CK-MB, ALT, AST and sCr, significantly increased. Other biochemical indexes, including BUN and hemodiastase, remained normal. Lactic acid significantly increased, while glucose, Hct% and THbc showed slight temporary increases and then returned to normal. These results on the acute toxicity and hematological changes should improve our understanding of the in vivo pathophysiological effects of TOE from C. capillata and indicate that it may also have neurotoxicity, liver toxicity and muscular toxicity in addition to hemolytic and cardiovascular toxicities, but no kidney or pancreatic toxicity.
authors: Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
authors: Liang
authors: L
authors: Xiao
authors: Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
authors: Sihua
authors: S
authors: Liu
authors: Department of Gynecology and Obstetrics, Shanghai Hospital, Second Military Medical University, Shanghai 200433, China.
authors: Qian
authors: Q
authors: He
authors: Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
authors: Qianqian
authors: Q
authors: Wang
authors: Department of Biophysics, School of Basic Medical, Second Military Medical University, Shanghai 200433, China.
authors: Xuting
authors: X
authors: Ye
authors: Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
authors: Guoyan
authors: G
authors: Liu
authors: Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
authors: Fei
authors: F
authors: Nie
authors: Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
authors: Jie
authors: J
authors: Zhao
authors: Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
authors: Liming
authors: L
authors: Zhang
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D003064:Cnidarian Venoms / Q000633:toxicity*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006402:Hematologic Diseases / Q000139:chemically induced*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009420:Nervous System / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D037401:Scyphozoa; D023382:Toxicity Tests, Acute
chemical_list: D003064:Cnidarian Venoms