title: Characterization of individual ultrasound microbubble dynamics with a light-scattering system.
abstract: Ultrasound microbubbles are contrast agents used for diagnostic ultrasound imaging and as carriers for noninvasive payload delivery. Understanding the acoustic properties of individual microbubble formulations is important for optimizing the ultrasound imaging parameters for improved image contrast and efficient payload delivery. We report here a practical and simple optical tool for direct real-time characterization of ultrasound contrast microbubble dynamics based on light scattering. Fourier transforms of raw linear and nonlinear acoustic oscillations, and microbubble cavitations are directly recorded. Further, the power of this tool is demonstrated by comparing clinically relevant microbubble cycle-to-cycle dynamics and their corresponding Fourier transforms.
authors: University of California at San Diego, Department of Electrical and Computer Engineering, 9500 Gilman Drive, Mail Code 0407, La Jolla, California 92092, USA. mhsu@ziva-corp.com
authors: Mark J
authors: MJ
authors: Hsu
authors: Mohammad
authors: M
authors: Eghtedari
authors: Andrew P
authors: AP
authors: Goodwin
authors: David J
authors: DJ
authors: Hall
authors: Robert F
authors: RF
authors: Mattrey
authors: Sadik C
authors: SC
authors: Esener
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D005583:Fourier Analysis; D008027:Light; D045423:Microbubbles; D017711:Nonlinear Dynamics; D012542:Scattering, Radiation; D014463:Ultrasonography / Q000379:methods*
chemical_list: D003287:Contrast Media