title: The effect of FTY720 in the Theiler's virus model of multiple sclerosis.
abstract: FTY720 (fingolimod) has demonstrated efficacy in multiple sclerosis (MS). We evaluated the effects of FTY720 on progressive disability, viral load, and antibody responses in mice infected with Theiler's murine encephalomyocarditis virus (TMEV). FTY720 and phosphorylated FTY720 (FTY720-P) were detected in the brain after intraperitoneal injection of the drug. Bioactivity of FTY720 was confirmed by reduced numbers of mononuclear cells in the spleen and blood after treatment. No significant differences were found in disability progression, viral load, and serum antibody responses between the FTY720-treated versus the PBS-treated mice. There was less production of IgG within the CNS in the FTY-treated group on some measures.
authors: Department of Neurology and Neuroscience, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA. lili@umdnj.edu
authors: Libin
authors: L
authors: Li
authors: Makiko
authors: M
authors: Matsumoto
authors: Timothy J
authors: TJ
authors: Seabrook
authors: Celine
authors: C
authors: Cojean
authors: Volker
authors: V
authors: Brinkman
authors: Andrew R
authors: AR
authors: Pachner
mesh_terms: D000818:Animals; D018188:Cardiovirus Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D000068876:Fingolimod Hydrochloride; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D051379:Mice; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000473:pathology* / Q000821:virology*; D011409:Propylene Glycols / Q000494:pharmacology / Q000627:therapeutic use*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D017945:Theilovirus / Q000187:drug effects* / Q000276:immunology; D019562:Viral Load / Q000187:drug effects / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D011409:Propylene Glycols; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine