title: First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 beta-lactamase in Klebsiella pneumoniae in Spain.
abstract: Twenty Klebsiella pneumoniae isolates producing OXA-48 were collected from April 2009 to September 2010. Strains were clonally related and coproduced a CTX-M-15 β-lactamase. A conjugative plasmid of circa 70 kb carrying bla(OXA-48) was identified. Eleven isolates showed low-level resistance to carbapenems, whereas nine showed high-level resistance. Decreased expression of OmpK36 was related to high-level resistance to carbapenems. The isolates belonged to sequence type 101 (ST101). This is the first outbreak caused by an OXA-48-producing K. pneumoniae strain in Spain.
authors: Department of Clinical Microbiology, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain. cristinapitart@gmail.com
authors: Cristina
authors: C
authors: Pitart
authors: Mar
authors: M
authors: Solé
authors: Ignasi
authors: I
authors: Roca
authors: Anna
authors: A
authors: Fàbrega
authors: Jordi
authors: J
authors: Vila
authors: Francesc
authors: F
authors: Marco
mesh_terms: D015780:Carbapenems / Q000378:metabolism* / Q000494:pharmacology*; D016521:Electrophoresis, Gel, Pulsed-Field; D004591:Electrophoresis, Polyacrylamide Gel; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D010957:Plasmids / Q000235:genetics*; D013030:Spain; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D015780:Carbapenems; D001618:beta-Lactamases; C108449:oxacillinase