title: Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population.
abstract: Twenty-four single-nucleotide polymorphisms (SNPs) have been reproducibly associated with obesity. We performed a follow-up study for obesity in the Greek adult population. A total of 510 obese and 469 lean adults were genotyped for 24 SNPs. We tested the association with obesity status using logistic regression and we evaluated the combined genetic risk of 24 SNPs by calculating the area under the receiver-operating characteristic (ROC) curves. We nominally replicated the association with obesity (BMI ≥30 kg/m(2)) of six SNPs in or near the FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 loci (1.28 ≤ odds ratio (OR) ≤ 1.35; 0.004 ≤ P ≤ 0.043). The discrimination ability for obesity was slightly stronger (P = 9.59 × 10(-6)) when the genetic information of the 24 SNPs was added to nongenetic risk factors (area under the curve (AUC) = 0.722) in comparison with nongenetic factors analyzed alone (AUC = 0.685). Our data suggest that SNPs in or near the FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 loci contribute to obesity risk in the Greek population.
authors: Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece. rouskas@bio.auth.gr
authors: Konstantinos
authors: K
authors: Rouskas
authors: Anastasia
authors: A
authors: Kouvatsi
authors: Konstantinos
authors: K
authors: Paletas
authors: Dimitrios
authors: D
authors: Papazoglou
authors: Apostolos
authors: A
authors: Tsapas
authors: Stéphane
authors: S
authors: Lobbens
authors: Vincent
authors: V
authors: Vatin
authors: Emmanuelle
authors: E
authors: Durand
authors: Yann
authors: Y
authors: Labrune
authors: Jérôme
authors: J
authors: Delplanque
authors: David
authors: D
authors: Meyre
authors: Philippe
authors: P
authors: Froguel
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D002135:Calcium-Binding Proteins; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008840:Microfilament Proteins; D008875:Middle Aged; D009479:Neuropeptides / Q000235:genetics*; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C112986:AIF1 protein, human; D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C470072:MC4R protein, human; D008565:Membrane Proteins; D008840:Microfilament Proteins; D009479:Neuropeptides; C403532:PCSK1N protein, human; D011506:Proteins; D044105:Receptor, Melanocortin, Type 4; C530715:TMEM18 protein, human; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human; C490198:PTP4A1 protein, human; D017027:Protein Tyrosine Phosphatases