title: Lysophosphatidic acid (LPA) and endothelial differentiation gene (Edg) receptors in human pancreatic cancer.
abstract: Lysophosphatidic acid (LPA) is a naturally occurring phospholipid with diverse effects on various cells, ranging from immediate morphological change to long-lasting cellular function alteration such as induction of stimulation of cell proliferation, survival, drug resistance, and motility. LPA interacts with cells through specific cell surface receptors. LPA1/Edg-2, LPA2/Edg-4, and LPA3/Edg-7 are three most common LPA receptors. Herein we review the roles of LPA and its receptors in the carcinogenesis of human malignancies, with focus on pancreatic cancer.
authors: Department of Medicine and Nursing Education, Professional College of Jiangsu Jiankang, Nanjing, China.
authors: G M
authors: GM
authors: Lv
authors: P
authors: P
authors: Li
authors: W D
authors: WD
authors: Wang
authors: Sh K
authors: ShK
authors: Wang
authors: J F
authors: JF
authors: Chen
authors: Y L
authors: YL
authors: Gong
mesh_terms: D000818:Animals; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D049349:Receptors, Lysosphingolipid / Q000378:metabolism*
chemical_list: D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C032881:lysophosphatidic acid