title: Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin.
abstract: Hydrophobic tag-assisted liquid-phase peptide synthesis technique and disulfide bond formation have been well-combined, leading to the efficient and practical preparation of a growth hormone-inhibiting peptide somatostatin. Intramolecular disulfide bond formation has successfully been carried out even under relatively high concentrations, enabling the effective peptide modifications in preparative scale.
authors: Department of Applied Life Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors: Shingo
authors: S
authors: Kitada
authors: Shuji
authors: S
authors: Fujita
authors: Yohei
authors: Y
authors: Okada
authors: Shokaku
authors: S
authors: Kim
authors: Kazuhiro
authors: K
authors: Chiba
mesh_terms: D000595:Amino Acid Sequence; D004220:Disulfides / Q000737:chemistry; D019382:Human Growth Hormone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D010084:Oxidation-Reduction; D013004:Somatostatin / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004220:Disulfides; D019382:Human Growth Hormone; D013004:Somatostatin