title: Apelin, vaspin, visfatin and adiponectin in large for gestational age infants with insulin resistance.
abstract: OBJECTIVE
  To investigate the relation of circulating four adipokines (apelin, vaspin, visfatin, adiponectin) with markers of insulin sensitivity in large for gestational age (LGA) infants.
  
  
  METHODS
  Forty LGA infants (20 LGA born from diabetic mothers and 20 LGA born from non-diabetic mothers) and 34 appropriate for gestational age (AGA) infants were recruited. Hyperinsulinism and insulin resistance was evaluated using the homeostasis model assessment (HOMA-IR), fasting glucose-to-insulin ratio (FGIR), quantitative insulin-sensitivity check index (QUICK-I) from fasting samples. Plasma adiponectin and vaspin levels were determined by radioimmunoassay. Determination of visfatin and apelin levels was performed by enzyme immunoassay.
  
  
  RESULTS
  HOMA-IR, apelin and visfatin levels (p<0.001, p<0.001, p<0.001, respectively) were significantly elevated and adiponectin levels, FGIR and QUICK-I values. (p<0.001, p<0.001, p<0.05, respectively) were significantly lower in the LGA group. Vaspin levels were higher in the LGA group than AGA neonates without a significance. The LGA infants with diabetic mother had significantly higher visfatin, apelin, HOMA-IR values, fasting insulin levels and significantly lower adiponectin, FGIR, QUICK-I values. Apelin and visfatin were correlated positively, and adiponectin was correlated negatively with birthweight, HOMA-IR values and fasting insulin levels.
  
  
  CONCLUSIONS
  Based on the findings of this study, it is too difficult to explain relation between birthweight and these adipocytokines, but findings of high insulin, HOMA-IR, visfatin, apelin and low adiponectin levels in the LGA neonates showed that these adipocytokines can be used as a good predictor for metabolic syndrome.
authors: Department of Pediatrics, Division of Neonatology, GATA Medical Faculty, Ankara, Turkey. ferhat_cocuk@hotmail.com
authors: Ferhat
authors: F
authors: Cekmez
authors: Fuat Emre
authors: FE
authors: Canpolat
authors: Ozgur
authors: O
authors: Pirgon
authors: Merih
authors: M
authors: Çetinkaya
authors: Secil
authors: S
authors: Aydinoz
authors: Selami
authors: S
authors: Suleymanoglu
authors: Osman Metin
authors: OM
authors: Ipcioglu
authors: Serdar Umit
authors: SU
authors: Sarici
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000073861:Apelin; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D015843:Serpins / Q000097:blood*
chemical_list: C115436:APLN protein, human; D052242:Adiponectin; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins; C507339:SERPINA12 protein, human; D015843:Serpins; D054409:Nicotinamide Phosphoribosyltransferase