title: [Britton Chance (1913-2010)--from sailing to biophysics and biochemistry and back].
abstract: A short CV of Britton Chance, an outstanding American biophysicist and biochemists, who has passed away in November 2010, is presented. Chance invented and applied in biochemical research fast recording of difference spectra during chemical reactions. Due to this technique he discovered and studied formation of enzyme-substrate complexes as exemplified by the peroxidase reaction. He also described spectral changes of electron carriers of mitochondrial respiratory chain that accompany transition from the resting to the active (phosphorylating) states. Applying vibrating platinum electrode, he recorded changes in the rate of oxygen uptake by isolated mitochondria in resting and phosphorylating states and defined the so-called respiratory states, called after his name. He was the first to describe formation of reactive oxygen species by mitochondria. Britton Chance was a devoted yachtsman and won a gold medal for the United States in sailing at the 1952 Olympic Games in Helsinki.
authors: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego PAN, ul. Pasteura 3, 02-093 Warszawa. l.wojtczak@nencki.gov.pl
authors: Lech
authors: L
authors: Wojtczak
mesh_terms: D001703:Biophysics / Q000266:history*; D005197:Famous Persons; D049673:History, 20th Century; D049674:History, 21st Century; D007124:Immunoenzyme Techniques / Q000266:history*; D008928:Mitochondria / Q000378:metabolism; D010101:Oxygen Consumption; D017382:Reactive Oxygen Species / Q000378:metabolism; D013177:Sports / Q000266:history; D014481:United States
chemical_list: D017382:Reactive Oxygen Species