title: Association between the T869C polymorphism of transforming growth factor-beta 1 and diabetic nephropathy: a meta-analysis.
abstract: Accumulating evidence has suggested that transforming growth factor-beta 1 (TGF-β1) is a functional candidate for diabetic nephropathy (DN). However, association studies investigating the relationship of TGF-β1 gene T869C polymorphism and DN generate inconsistent results. To comprehensively clarify this issue, we performed a meta-analysis to evaluate the impact of the polymorphism on DN. We searched studies from PubMed and China National Knowledge Infrastructure (CNKI) through March 2011. Pooled ORs were calculated under allelic/additive/dominant/recessive/over-dominant genetic models. Nine studies with 1776 cases and 1740 controls were included. Our results indicated that C allele of T869C conferred a significantly increased risk of DN compared with T allele (OR = 1.25, 95% CI: 1.05-1.48) for allelic contrast. Similar results were also found under additive (OR = 1.57, 95% CI: 1.10-2.23) and dominant (OR = 1.40, 95% CI: 1.06-1.85) genetic models. However, subgroup analyses stratified by types of diabetes showed that significantly increased risks were only observed in type 2 diabetic patients, and the association persistently existed in further analysis for Asian populations. As for type 1 diabetic subjects, no significant association was detected under all the genetic models (P > 0.05). Our meta-analysis suggested that the TGF-β1 T869C polymorphism conferred an elevated risk of DN. However, significant associations were only observed in type 2 diabetic patients.
authors: Department of Endocrinology and Metabolism, Xijing Hospital, Fourth Military Medical University, 169 West Changle Road, Xi'an, Shaanxi, 710032, People's Republic of China.
authors: Hongxia
authors: H
authors: Jia
authors: Lili
authors: L
authors: Yu
authors: Bin
authors: B
authors: Gao
authors: Qiuhe
authors: Q
authors: Ji
mesh_terms: D016022:Case-Control Studies; D048909:Diabetes Complications / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1