title: Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice.
abstract: N-acyl-phosphatidylethanolamine is a precursor phospholipid for anandamide, oleoylethanolamide, and other N-acylethanolamines, and it may in itself have biological functions in cell membranes. Recently, N-palmitoyl-phosphatidylethanolamine (NAPE) has been reported to function as an anorectic hormone secreted from the gut and acting on the brain (Gillum et al., [5]). In the current study, two of our laboratories independently investigated whether NAPE metabolites may be involved in mediating the anorectic action of NAPE i.p. injected in mice. Thus, the anorectic activity of a non-hydrolysable NAPE analogue, having ether bonds instead of ester bonds at sn1 and sn2 was compared with that of NAPE in molar equivalent doses. Furthermore, the anorectic effect of NAPE in NAPE-hydrolysing phospholipase D knockout animals was investigated. As negative controls, the NAPE precursor phosphatidylethanolamine and the related phospholipids phosphatidylcholine and phosphatidic acid were also tested. All compounds except one were found to inhibit food intake, raising the possibility that the effect of NAPE is non-specific.
authors: Department of Pharmacology & Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
authors: Niels
authors: N
authors: Wellner
authors: Kazuhito
authors: K
authors: Tsuboi
authors: Andreas Nygaard
authors: AN
authors: Madsen
authors: Birgitte
authors: B
authors: Holst
authors: Thi Ai
authors: TA
authors: Diep
authors: Michiyasu
authors: M
authors: Nakao
authors: Akira
authors: A
authors: Tokumura
authors: Matthew P
authors: MP
authors: Burns
authors: Dale G
authors: DG
authors: Deutsch
authors: Natsuo
authors: N
authors: Ueda
authors: Harald Severin
authors: HS
authors: Hansen
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D010714:Phosphatidylethanolamines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010739:Phospholipase D / Q000235:genetics / Q000378:metabolism
chemical_list: D001067:Appetite Depressants; D010714:Phosphatidylethanolamines; D010739:Phospholipase D