title: Therapeutic factors secreted by mesenchymal stromal cells and tissue repair.
abstract: Systemic administration of MSCs resulted in remarkable functional improvements in injured tissues without either long-term engraftment or differentiation in many clinical and experimental situations. Emerging evidence suggest that most of the beneficial effects of MSCs could be explained by secretion of soluble factors that have multiple effects including modulation of inflammatory and immune reactions, protection from cell death, and stimulation of endogenous progenitor cells. In this review, we focus on the therapeutic factors that account for the beneficial effects of MSCs in animal models of human diseases.
authors: Texas A&M Health Science Center, College of Medicine, Institute for Regenerative Medicine at Scott & White, Temple, Texas 76502, USA. RLee@medicine.tamhsc.edu
authors: Ryang Hwa
authors: RH
authors: Lee
authors: Joo Youn
authors: JY
authors: Oh
authors: Hosoon
authors: H
authors: Choi
authors: Nikolay
authors: N
authors: Bazhanov
mesh_terms: D017209:Apoptosis; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D012038:Regeneration; D014945:Wound Healing