title: In vitro characterization of an electroactive carbon-nanotube-based nanofiber scaffold for tissue engineering.
abstract: In an effort to reduce organ replacement and enhance tissue repair, there has been a tremendous effort to create biomechanically optimized scaffolds for tissue engineering applications. In contrast, the development and characterization of electroactive scaffolds has attracted little attention. Consequently, the creation and characterization of a carbon nanotube based poly(lactic acid) nanofiber scaffold is described herein. After 28 d in physiological solution at 37 °C, a change in the mass, chemical properties and polymer morphology is seen, while the mechanical properties and physical integrity are unaltered. No adverse cytotoxic affects are seen when mesenchymal stem cells are cultured in the presence of the scaffold. Taken together, these data auger well for electroactive tissue engineering.
authors: Regenerative Medicine Institute (REMEDI), National Center for Biomedical Engineering Science (NCBES), Orbsen Building, National University of Ireland, Galway, University Road, Galway, Ireland.
authors: Joseph N
authors: JN
authors: Mackle
authors: David J-P
authors: DJ
authors: Blond
authors: Emma
authors: E
authors: Mooney
authors: Caitlin
authors: C
authors: McDonnell
authors: Werner J
authors: WJ
authors: Blau
authors: Georgina
authors: G
authors: Shaw
authors: Frank P
authors: FP
authors: Barry
authors: J Mary
authors: JM
authors: Murphy
authors: Valerie
authors: V
authors: Barron
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002478:Cells, Cultured; D055664:Electrochemical Techniques; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D037742:Nanotubes, Carbon / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D013314:Stress, Mechanical; D013718:Tensile Strength; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)