title: Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.
abstract: OBJECTIVE
  We aimed to analyse the in vitro fertilization-embryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin.
  
  
  METHODS
  A total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n=30) had underwent the IVF-ET with melatonin administration and the control group (group B, n=30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups.
  
  
  RESULTS
  Sleeping status change was not significant (p>0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p=0.0001; p=0.0001; p<0.05 respectively.
  
  
  CONCLUSIONS
  IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.
authors: IVF Department, Zekai Tahir Burak Women Education and Research Hospital, Devlet Mah. Subay Loj. Hızırreis Apt. No: 19/11, Yenisehir, Ankara, Turkey. drozlemgun@yahoo.com
authors: Ozlem Gun
authors: OG
authors: Eryilmaz
authors: Aysun
authors: A
authors: Devran
authors: Esma
authors: E
authors: Sarikaya
authors: Fatma Nur
authors: FN
authors: Aksakal
authors: Leyla
authors: L
authors: Mollamahmutoğlu
authors: Nedim
authors: N
authors: Cicek
mesh_terms: D002492:Central Nervous System Depressants / Q000494:pharmacology* / Q000627:therapeutic use; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000188:drug therapy; D008550:Melatonin / Q000494:pharmacology* / Q000627:therapeutic use; D009865:Oocytes / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D012893:Sleep Wake Disorders / Q000150:complications / Q000188:drug therapy*; D013315:Stress, Psychological / Q000150:complications / Q000188:drug therapy
chemical_list: D002492:Central Nervous System Depressants; D008550:Melatonin