title: Kinetic modelling and residue depletion of drugs in eggs.
abstract: 1. A physiologically-based pharmacokinetic model was developed for the purpose of describing the relationship between plasma concentration of drugs and their deposition into eggs. 2. By incorporating the physiology of egg formation into the model, the transfer of drugs into the egg albumen and yolk could be described using rate constants. 3. The model was used to describe concentrations in albumen and yolk of sulphanilamide, sulphaquinoxaline and pyrimethamine as a function of time using datasets from the literature. 4. The model could be used as a tool to obtain an insight into those properties of a drug which are responsible for the amount of residue in eggs, and could help in the design of critical studies for determining withdrawal periods for eggs.
authors: Medicines Evaluation Board, Veterinary Medicines Unit, Den Haag, The Netherlands.
authors: P
authors: P
authors: Hekman
authors: G J
authors: GJ
authors: Schefferlie
mesh_terms: D000818:Animals; D004529:Egg White / Q000737:chemistry; D004530:Egg Yolk / Q000737:chemistry; D004531:Eggs; D007700:Kinetics; D008954:Models, Biological; D011200:Poultry / Q000378:metabolism*; D011739:Pyrimethamine / Q000032:analysis / Q000493:pharmacokinetics*; D000077145:Sulfanilamide; D013424:Sulfanilamides / Q000032:analysis / Q000493:pharmacokinetics*; D013428:Sulfaquinoxaline / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D013424:Sulfanilamides; D000077145:Sulfanilamide; D013428:Sulfaquinoxaline; D011739:Pyrimethamine