title: Positive outcomes of oil palm phenolics on degenerative diseases in animal models.
abstract: It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals.
authors: Malaysian Palm Oil Board, Persiaran Institusi, Bandar Baru Bangi, Kajang, Selangor, Malaysia. raviga@mpob.gov.my
authors: Ravigadevi
authors: R
authors: Sambanthamurthi
authors: YewAi
authors: Y
authors: Tan
authors: Kalyana
authors: K
authors: Sundram
authors: Kenneth C
authors: KC
authors: Hayes
authors: Mahinda
authors: M
authors: Abeywardena
authors: Soon-Sen
authors: SS
authors: Leow
authors: Shamala Devi
authors: SD
authors: Sekaran
authors: T G
authors: TG
authors: Sambandan
authors: ChoKyun
authors: C
authors: Rha
authors: Anthony J
authors: AJ
authors: Sinskey
authors: Krishnan
authors: K
authors: Subramaniam
authors: Syed
authors: S
authors: Fairus
authors: Mohd Basri
authors: MB
authors: Wahid
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D050197:Atherosclerosis / Q000517:prevention & control; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000172:deficiency; D000073878:Palm Oil; D010636:Phenols / Q000627:therapeutic use*; D010938:Plant Oils / Q000737:chemistry / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D011921:Rats, Inbred WKY
chemical_list: D010636:Phenols; D010938:Plant Oils; D009569:Nitric Oxide; D000073878:Palm Oil