title: Association of chronic kidney disease and coronary artery disease in 1,010 consecutive patients undergoing coronary angiography.
abstract: BACKGROUND
  Patients with chronic kidney disease (CKD) are more likely to have complications due to cardiovascular disease (CVD). This study was performed to investigate the prevalence of chronic kidney disease (CKD) and the relation of CKD and number of stenosed coronary vessels in patients who had undergone coronary angiography with suspected coronary artery disease (CAD).
  
  
  METHODS
  The data of 1,010 consecutive patients who underwent coronary angiography for suspected CAD in Zhongda Hospital were analyzed. Estimated glomerular filtration rate (eGFR) was calculated with the abbreviated Modified Diet in Renal Disease (MDRD) Study equation. CKD was defined as presence of eGFR <60 ml/min per 1.73 m(2) and/or proteinuria. Luminal narrowing with at least 1 lesion =50% in the main branches of the coronary artery was considered as CAD. The number of stenotic arteries was recorded (1- to 3-vessel disease [VD]). A significant stenosis in the left main trunk was scored as 2-VD.
  
  
  RESULTS
  Patients with CAD had a significantly higher prevalence of CKD compared with patients without CAD (18.8% vs. 5.4%, p<0.001). CKD was significantly associated with CAD, 2-VD and 3-VD, versus without CAD (0-VD) (odds ratio [OR] = 2.163; 95% confidence interval [95% CI], 1.296-3.611; OR=2.478; 95% CI, 1.288-4.766; OR=2.504; 95% CI, 1.271-4.933; respectively) after adjustment for covariates.
  
  
  CONCLUSIONS
  There was a higher prevalence of CKD in patients with CAD diagnosed by coronary angiography, and it increased with the number of stenosed coronary vessels. CKD is a critical risk factor for CAD, especially 3-VD.
authors: Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, PR China.
authors: Hong
authors: H
authors: Liu
authors: Lei
authors: L
authors: Yan
authors: Gen-Shan
authors: GS
authors: Ma
authors: Li-Ping
authors: LP
authors: Zhang
authors: Min
authors: M
authors: Gao
authors: Yan-Li
authors: YL
authors: Wang
authors: Shuo-Peng
authors: SP
authors: Wang
authors: Bi-Cheng
authors: BC
authors: Liu
mesh_terms: D000368:Aged; D002908:Chronic Disease; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence