title: Spontaneous traumatic macular hole closure in a 50-year-old woman: a case report.
abstract: BACKGROUND
  Traumatic macular holes (TMH) are well-known complications of ocular contusion injury. Spontaneous closure occurs in approximately 50% of cases, but rarely after the age of thirty. We report a case of spontaneous closure of a full thickness macular hole due to a blunt trauma and we suggest possible mechanisms for this closure.
  
  
  METHODS
  A 50-year-old Greek woman was referred with a history of reduced best-corrected visual acuity after blunt trauma to her right eye. Diagnosis was based on fundoscopic, optical coherence tomography as well as fluorescein angiography findings with follow-up visits at two days, 20 days and five months. Fundoscopy revealed a full-thickness TMH with a minor sub-retinal hemorrhage and posterior vitreous detachment. The presence of a coagulum in the TMH base was observed. Subsequently, TMH closure was observed.
  
  
  CONCLUSIONS
  The clot in the TMH base, potentially a hemorrhage by-product containing a significant quantity of platelets, may have simulated the clot observed after autologous serum use, thus facilitating a similar effect. This may have stimulated glial cell migration and proliferation, thus contributing to spontaneous hole closure.
authors: 2nd Department of Ophthalmology, "Papageorgiou" General Hospital, School of Medicine, Aristotle University of Thessaloniki, Greece. sadimitr@med.auth.gr.
authors: Mayssa B
authors: MB
authors: Nasr
authors: Chrysanthos
authors: C
authors: Symeonidis
authors: Ioannis
authors: I
authors: Tsinopoulos
authors: Sofia
authors: S
authors: Androudi
authors: Tryfon
authors: T
authors: Rotsos
authors: Stavros A
authors: SA
authors: Dimitrakos