title: Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment.
abstract: Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.
authors: Department of Chemistry, University of British Columbia, Vancouver, BC, Canada, V6T 1Z1.
authors: David E
authors: DE
authors: Williams
authors: Doralyn S
authors: DS
authors: Dalisay
authors: Brian O
authors: BO
authors: Patrick
authors: Teatulohi
authors: T
authors: Matainaho
authors: Kerry
authors: K
authors: Andrusiak
authors: Raamesh
authors: R
authors: Deshpande
authors: Chad L
authors: CL
authors: Myers
authors: Jeff S
authors: JS
authors: Piotrowski
authors: Charles
authors: C
authors: Boone
authors: Minoru
authors: M
authors: Yoshida
authors: Raymond J
authors: RJ
authors: Andersen
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D019015:Geologic Sediments / Q000382:microbiology*; D006801:Humans; D019169:Jurkat Cells; D008958:Models, Molecular; D015394:Molecular Structure; D009842:Oligopeptides / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D009842:Oligopeptides; C568577:padanamide A; C568578:padanamide B