title: Mouse models of colorectal cancer.
abstract: Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models. However, none recapitulates all of the characteristics of human colorectal cancer. It is critical to use a specific mouse model to address a particular research question. Here, we review commonly used mouse models for human colorectal cancer.
authors: Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. tongy@cshs.org
authors: Yunguang
authors: Y
authors: Tong
authors: Wancai
authors: W
authors: Yang
authors: H Phillip
authors: HP
authors: Koeffler
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000473:pathology; D000818:Animals; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000209:etiology / Q000235:genetics / Q000473:pathology; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000473:pathology; D004195:Disease Models, Animal; D005818:Genetic Engineering; D006801:Humans; D007249:Inflammation / Q000150:complications; D051379:Mice; D008822:Mice, Transgenic; D009362:Neoplasm Metastasis