title: Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses.
abstract: BACKGROUND
  Aversively motivated learning is more poorly understood than appetitively motivated learning in many aspects, including the role of dopamine receptors in different regions of the striatum.
  
  
  OBJECTIVE
  The present study investigated the roles of the D1-like DA receptors in the nucleus accumbens (NAc) and dorsolateral striatum (DLS) on learning and performance of conditioned avoidance responses (CARs).
  
  
  METHODS
  Adult male Wistar rats received intraperitoneal (i.p.), intra-NAc, or intra-DLS injections of the D1 dopamine receptor agonist SKF 81297 or the D1 receptor antagonist SCH 23390 20 min before or immediately after a training session in the CAR task two-way active avoidance, carried out 24 h before a test session.
  
  
  RESULTS
  Pre-training administration of SCH 23390, but not SKF 81297, caused a significant decrease in the number of CARs in the test, but not in the training session, when injected into the DLS, or in either session when injected into the NAc. It also caused a significant increase in the number of escape failures in the training session when injected into the NAc. Systemic administration caused a combination of these effects. Post-training administrations of these drugs caused no significant effect.
  
  
  CONCLUSIONS
  The results suggest that the D1-like receptors in the NAc and DLS play important, though different, roles in learning and performance of CAR.
authors: Departamento de Farmacologia, Laboratório de Fisiologia e Farmacologia do Sistema Nervoso Centra, C.P. 19.031, 81.531-980 UFPR, Curitiba, PR, Brazil.
authors: Evellyn Claudia
authors: EC
authors: Wietzikoski
authors: Suelen Lúcio
authors: SL
authors: Boschen
authors: Edmar
authors: E
authors: Miyoshi
authors: Mariza
authors: M
authors: Bortolanza
authors: Lucélia Mendes
authors: LM
authors: Dos Santos
authors: Michael
authors: M
authors: Frank
authors: Marcus Lira
authors: ML
authors: Brandão
authors: Philip
authors: P
authors: Winn
authors: Claudio
authors: C
authors: Da Cunha
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1