title: Unusual seminoma revealed by bone metastasis.
abstract: We report a first case of primitive mediastinal seminoma revealed by bone metastasis without testicular tumor. In a 24-year-old patient with a 6-month history of isolated right hip pain, having normal X-ray and blood tests, we discovered a clinically silent chest mass being diagnosed as seminoma on needle biopsy. Etoposide-ifosfamide-cisplatin chemotherapy was chosen because of the presence of multiple lesions and its lesser toxicity. Germ cell tumors are a rare cause of bone metastases and need to be known to rheumatologists because of their excellent prognosis when recognized and treated early. We discuss new diagnostic (CT, MRI and PET-Scan) and treatment (chemotherapy and radiotherapy) strategies applied to our patient.
authors: Service d'immunorhumatologie, CHU Lapeyronie, 34000 Montpellier, France. pit braquet@hotmail.com
authors: Pierre
authors: P
authors: Braquet
authors: Angélique
authors: A
authors: Chapelle
authors: Christian
authors: C
authors: Jorgensen
authors: Yves-Marie
authors: YM
authors: Pers
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary*; D002945:Cisplatin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005047:Etoposide / Q000627:therapeutic use; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D049268:Positron-Emission Tomography; D018239:Seminoma / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005047:Etoposide; D002945:Cisplatin; D007069:Ifosfamide