title: Memory B cells and CD8⁺ lymphocytes do not control seasonal influenza A virus replication after homologous re-challenge of rhesus macaques.
abstract: This study sought to define the role of memory lymphocytes in the protection from homologous influenza A virus re-challenge in rhesus macaques. Depleting monoclonal antibodies (mAb) were administered to the animals prior to their second experimental inoculation with a human seasonal influenza A virus strain. Treatment with either anti-CD8α or anti-CD20 mAbs prior to re-challenge had minimal effect on influenza A virus replication. Thus, in non-human primates with pre-existing anti-influenza A antibodies, memory B cells and CD8α⁺ T cells do not contribute to the control of virus replication after re-challenge with a homologous strain of influenza A virus.
authors: Center for Comparative Medicine, University of California Davis, Davis, California, United States of America.
authors: Timothy D
authors: TD
authors: Carroll
authors: Shannon R
authors: SR
authors: Matzinger
authors: Linda
authors: L
authors: Fritts
authors: Michael B
authors: MB
authors: McChesney
authors: Christopher J
authors: CJ
authors: Miller
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D018951:Antigens, CD20 / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000821:virology*; D016827:CD8 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000821:virology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007114:Immunization; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology / Q000502:physiology*; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology; D008253:Macaca mulatta; D012621:Seasons; D013045:Species Specificity; D014779:Virus Replication / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D018951:Antigens, CD20; D016827:CD8 Antigens; C431698:CD8alpha antigen