title: Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization.
abstract: By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.
authors: Department of Medical and Bioengineering Science, Chemical Biology Area, Division of Chemistry and Biochemistry, Okayama University, 1-1-1, Tsushimanaka, Okayama, 700-0082, Japan.
authors: Toshimasa
authors: T
authors: Hamamoto
authors: Masahiko
authors: M
authors: Sisido
authors: Takashi
authors: T
authors: Ohtsuki
authors: Masumi
authors: M
authors: Taki
mesh_terms: D000595:Amino Acid Sequence; D003500:Cyclization; D003545:Cysteine / Q000138:chemical synthesis / Q000737:chemistry*; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010456:Peptides, Cyclic; D003545:Cysteine