title: Repeated cisplatin treatments inhibit gastrointestinal motility and induces baroreflex changes and mechanical hyperalgesia in rats.
abstract: Cisplatin is a chemotherapy agent known for its neurotoxicity. We evaluated the effect of cisplatin on the gastric emptying (GE), gastrointestinal (GI) transit of liquid, baroreflex function, thermal, and mechanical withdrawal latencies in rats. Cisplatin increased the GE of liquid with doses ≥ 2 mg.kg(-1) by 59.7-77.4%. This GE delay was not present two weeks after the treatment with five doses of cisplatin at 1 mg.kg(-1). Cisplatin also enhanced baroreflex gain possibly by increasing sympathetic activity. Our results demonstrated that cisplatin (2-10 mg.kg(-1)) causes autonomic neuropathy with GI and baroreflex changes and mechanical but not thermal hyperalgesia in rats.
authors: Department of Physiology and Pharmacology, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil. kvvc2004@yahoo.com.br
authors: Kátia Virginia
authors: KV
authors: Viana-Cardoso
authors: Moisés Tolentino B
authors: MT
authors: da Silva
authors: Raimundo Campos Palheta
authors: RC
authors: Júnior
authors: Arnaldo A
authors: AA
authors: Peixoto Junior
authors: Lucas Gomes
authors: LG
authors: Pinho
authors: Armenio Aguiar Dos
authors: AA
authors: Santos
authors: Ronaldo A
authors: RA
authors: Ribeiro
authors: Francisco Hélio
authors: FH
authors: Rola
authors: Francisco de Assis A
authors: Fde A
authors: Gondim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D017704:Baroreflex / Q000187:drug effects*; D002945:Cisplatin / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects; D006930:Hyperalgesia / Q000139:chemically induced*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin