title: Comparative structural analysis of lipid binding START domains.
abstract: BACKGROUND
  Steroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind. These domains can transport ligands to facilitate lipid exchange between biological membranes, and they have been postulated to modulate the activity of other domains of the protein in response to ligand binding. More than a dozen human genes encode START domains, and several of them are implicated in a disease.
  
  
  RESULTS
  We report crystal structures of the human STARD1, STARD5, STARD13 and STARD14 lipid transfer domains. These represent four of the six functional classes of START domains.
  
  
  CONCLUSIONS
  Sequence alignments based on these and previously reported crystal structures define the structural determinants of human START domains, both those related to structural framework and those involved in ligand specificity.
  
  
  BACKGROUND
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authors: Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden.
authors: Ann-Gerd
authors: AG
authors: Thorsell
authors: Wen Hwa
authors: WH
authors: Lee
authors: Camilla
authors: C
authors: Persson
authors: Marina I
authors: MI
authors: Siponen
authors: Martina
authors: M
authors: Nilsson
authors: Robert D
authors: RD
authors: Busam
authors: Tetyana
authors: T
authors: Kotenyova
authors: Herwig
authors: H
authors: Schüler
authors: Lari
authors: L
authors: Lehtiö
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D018360:Crystallography, X-Ray / Q000379:methods*; D020690:GTPase-Activating Proteins; D006801:Humans; D010170:Palmitoyl-CoA Hydrolase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010750:Phosphoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D000098682:Steroidogenic Acute Regulatory Protein
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins; D020690:GTPase-Activating Proteins; D010750:Phosphoproteins; C473607:STARD13 protein, human; C456546:STARD5 protein, human; D025521:Tumor Suppressor Proteins; D000098682:Steroidogenic Acute Regulatory Protein; C499088:ACOT11 protein, human; D010170:Palmitoyl-CoA Hydrolase