title: Expression of galectin-9 by IFN-γ stimulated human nasal polyp fibroblasts through MAPK, PI3K, and JAK/STAT signaling pathways.
abstract: Galectin-9 exhibited potent and selective eosinophil chemoattractant activity and attracted eosinophils in vitro and in vivo. Nasal polyposis is a chronic inflammatory disease of the upper airway characterized by the marked presence of inflammatory cells, particularly eosinophils. Thus, galectin-9 may be implicated in the pathogenesis of nasal polyposis. The study was designed to investigate whether interferon-gamma (IFN-γ) can induce the augmentation of galectin-9 expression and induce the expression of galectin-9 in nasal polyps. We examined the correlation between galectin-9 expression and eosinophil infiltration in nasal polyps. In addition, we identified the signaling pathways involved in the elevation of galectin-9 expression in response to IFN-γ. Our data demonstrate that the involvement of mitogen-activated protein kinases (MAPKs), phosphatidylinositol 3 phosphate kinase (PI3K), and Janus kinase/signal transducer and activator of transcription (JAK/STAT) may play important roles in the selective recruitment of eosinophils in nasal polyp tissues through the production of galectin-9. These findings suggest that galectin-9 expression is associated with eosinophil infiltration in polyps of patients with nasal polyposis.
authors: Department of Physiology, Kangwon National University School of Medicine, Chuncheon 200-701, Republic of Korea.
authors: Won Sun
authors: WS
authors: Park
authors: Won-Kyo
authors: WK
authors: Jung
authors: Seong Kook
authors: SK
authors: Park
authors: Kyung Wook
authors: KW
authors: Heo
authors: Mi-Seon
authors: MS
authors: Kang
authors: Yung Hyun
authors: YH
authors: Choi
authors: Gi-Young
authors: GY
authors: Kim
authors: Sae-Gwang
authors: SG
authors: Park
authors: Su-Kil
authors: SK
authors: Seo
authors: Sung Su
authors: SS
authors: Yea
authors: Kwang-Hyeon
authors: KH
authors: Liu
authors: Eun Bo
authors: EB
authors: Shim
authors: Dae-Joong
authors: DJ
authors: Kim
authors: Minyoung
authors: M
authors: Her
authors: Il-Whan
authors: IW
authors: Choi
mesh_terms: D002478:Cells, Cultured; D004804:Eosinophils / Q000187:drug effects / Q000276:immunology*; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology; D037161:Galectins / Q000096:biosynthesis*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology* / Q000494:pharmacology; D053612:Janus Kinases / Q000378:metabolism*; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D009298:Nasal Polyps / Q000276:immunology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism
chemical_list: D037161:Galectins; C105032:LGALS9 protein, human; D050791:STAT Transcription Factors; D007371:Interferon-gamma; D019869:Phosphatidylinositol 3-Kinases; D053612:Janus Kinases; D020929:Mitogen-Activated Protein Kinase Kinases