title: Temperature sensitivity trends and multi-stimuli sensitive behavior in amphiphilic oligomers.
abstract: A series of oligomers, containing oligo(ethylene glycol) (OEG) moieties, with the same composition of amphiphilic functionalities has been designed, synthesized, and characterized on the basis of their temperature-sensitive behavior. The non-covalent amphiphilic aggregates, formed from these molecules, influence their temperature sensitivity. Covalent tethering of the amphiphilic units also has a significant influence on their temperature sensitivity. The lower critical solution temperatures of these oligomers show increasingly sharp transitions with increasing numbers of OEG functional groups, indicating enhanced cooperativity in dehydration of the OEG moieties when they are covalently tethered. These molecules were also engineered to be concurrently sensitive to enzymatic reaction and pH. This possibility was investigated using porcine liver esterase as the enzyme; we show that enzymatic action on the pentamer lowers its temperature sensitivity. The product moiety from the enzymatic reaction also gives the amphiphilic oligomer a pH-dependent temperature sensitivity.
authors: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.
authors: Feng
authors: F
authors: Wang
authors: Akamol
authors: A
authors: Klaikherd
authors: S
authors: S
authors: Thayumanavan
mesh_terms: D000818:Animals; D004950:Esterases / Q000378:metabolism; D019855:Ethylene Glycol / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D013552:Swine; D013696:Temperature
chemical_list: D013501:Surface-Active Agents; D004950:Esterases; D019855:Ethylene Glycol