title: Location matters: the endoplasmic reticulum and protein trafficking in dendrites.
abstract: Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.
authors: Program of Physiology and Biophysics, , Institute of Biomedical Sciences, Universidad de Chile, Santiago.
authors: Omar A
authors: OA
authors: Ramírez
authors: Steffen
authors: S
authors: Härtel
authors: Andrés
authors: A
authors: Couve
mesh_terms: D002463:Cell Membrane Permeability / Q000502:physiology*; D003712:Dendrites / Q000378:metabolism / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology
chemical_list: D008565:Membrane Proteins