title: Rhinocerebral mucormycosis: experience in 14 patients.
abstract: OBJECTIVE
  Mucormycosis is an opportunist, often lethal fungal infection which occurs in immunocompromised patients. We present our experience in 14 patients with this condition.
  
  
  METHODS
  A retrospective chart review was conducted for 14 patients treated for rhinocerebral mucormycosis.
  
  
  RESULTS
  Nine patients had diabetes mellitus and six had a haematological malignancy. Nine patients had cutaneous and/or palatal necrosis. Eleven patients were treated with amphotericin B and five with liposomal amphotericin B. Endoscopic sinus surgery was performed in five patients with disease limited to the sinonasal cavity; nine patients underwent more extensive surgery. Five patients with disease limited to the sinonasal cavity survived, while nine patients with widely disseminated disease died. Five of the nine diabetic patients died, as did five of the six patients with haematological malignancy.
  
  
  CONCLUSIONS
  Patients with rhinocerebral mucormycosis spreading outside the sinonasal cavity have a poor prognosis.
authors: Department of Otorhinolaryngology, Erciyes University, Kayseri, Turkey. ketenci@erciyes.edu.tr
authors: I
authors: I
authors: Ketenci
authors: Y
authors: Y
authors: Unlü
authors: H
authors: H
authors: Kaya
authors: M A
authors: MA
authors: Somdaş
authors: O
authors: O
authors: Kontaş
authors: M
authors: M
authors: Oztürk
authors: A
authors: A
authors: Vural
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D016883:Diabetic Ketoacidosis / Q000150:complications; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009668:Nose Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D009916:Orbital Diseases / Q000382:microbiology / Q000473:pathology; D010159:Palate / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B