title: Lung transplantation and coronary artery disease.
abstract: BACKGROUND
  Coronary artery disease (CAD) remains a relative contraindication to lung transplantation. We have offered lung transplantation and coronary revascularization to selected patients with discrete CAD and preserved left ventricular function. The purpose of this report is the following: (1) to examine the short-term and medium-term outcome of patients after coronary revascularization and lung transplantation; and (2) to compare the short-term and medium-term outcome of this cohort to a matched group of lung transplant recipients without CAD.
  
  
  METHODS
  From January 2000 to March 2010, 27 patients with CAD underwent coronary revascularization and lung transplantation. The control group was matched based on age, diagnosis, lung allocation score, and type of procedure.
  
  
  RESULTS
  Lung transplant recipients with CAD and the control group had similar incidence of primary graft dysfunction (grade III). The duration of mechanical ventilation, intensive care unit stay, and hospital stay were the same. At a mean follow-up of 3 years, the incidence of composite adverse cardiac events was similar in the 2 groups.
  
  
  CONCLUSIONS
  Lung transplant recipients with CAD and the control group also had similar medium-term survival. Lung transplantation can be considered in patients with preexistent CAD with acceptable early and medium-term outcomes.
authors: Division of Cardiothoracic Surgery, Department of Surgery, Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90095, USA.
authors: William
authors: W
authors: Sherman
authors: David G
authors: DG
authors: Rabkin
authors: David
authors: D
authors: Ross
authors: Rajan
authors: R
authors: Saggar
authors: Joseph P
authors: JP
authors: Lynch
authors: John
authors: J
authors: Belperio
authors: Rajeev
authors: R
authors: Saggar
authors: Michele
authors: M
authors: Hamilton
authors: Abbas
authors: A
authors: Ardehali
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002423:Cause of Death; D003131:Combined Modality Therapy; D001026:Coronary Artery Bypass / Q000379:methods / Q000401:mortality*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D053208:Kaplan-Meier Estimate; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D016040:Lung Transplantation / Q000379:methods / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis