title: ESR1, FTO, and UCP2 genes interact with bariatric surgery affecting weight loss and glycemic control in severely obese patients.
abstract: BACKGROUND
  Significant variability in weight loss and glycemic control has been observed in obese patients receiving bariatric surgery. Genetic factors may play a role in the different outcomes.
  
  
  METHODS
  Five hundred and twenty severely obese patients with body mass index (BMI) ≥35 were recruited. Among them, 149 and 371 subjects received laparoscopic adjustable gastric banding (LAGB) and laparoscopic mini-gastric bypass (LMGB), respectively. All individuals were genotyped for five obesity-related single nucleotide polymorphisms on ESR1, FTO, PPARγ, and UCP2 genes to explore how these genes affect weight loss and glycemic control after bariatric surgery at the 6th month.
  
  
  RESULTS
  Obese patients with risk genotypes on rs660339-UCP2 had greater decrease in BMI after LAGB compared to patients with non-risk genotypes (-7.5 vs. -6 U, p = 0.02). In contrast, after LMGB, obese patients with risk genotypes on either rs712221-ESR1 or rs9939609-FTO had significant decreases in BMI (risk vs. non-risk genotype, -12.5 vs. -10.0 U on rs712221, p = 0.02 and -12.1 vs. -10.6 U on rs9939609, p = 0.04) and a significant amelioration in HbA1c levels (p = 0.038 for rs712221 and p < 0.0001 for rs9939609). The synergic effect of ESR1 and FTO genes on HbA1c amelioration was greater (-1.54%, p for trend <0.001) than any of these genes alone in obese patients receiving LMGB.
  
  
  CONCLUSIONS
  The genetic variants in the ESR, FTO, and UCP2 genes may be considered as a screening tool prior to bariatric surgery to help clinicians predict weight loss or glycemic control outcomes for severely obese patients.
authors: Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
authors: Tsan-Hon
authors: TH
authors: Liou
authors: Hsin-Hung
authors: HH
authors: Chen
authors: Weu
authors: W
authors: Wang
authors: Shu-Fen
authors: SF
authors: Wu
authors: Yi-Chih
authors: YC
authors: Lee
authors: Wei-Shiung
authors: WS
authors: Yang
authors: Wei-Jei
authors: WJ
authors: Lee
mesh_terms: D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D015391:Gastroplasty / Q000379:methods; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D010535:Laparoscopy; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics*; D009767:Obesity, Morbid / Q000235:genetics* / Q000601:surgery*; D011506:Proteins / Q000235:genetics*; D012720:Severity of Illness Index; D000071246:Uncoupling Protein 2; D015431:Weight Loss / Q000235:genetics*
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D007473:Ion Channels; D024101:Mitochondrial Proteins; D011506:Proteins; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human