title: Cellular strategies of protein quality control.
abstract: Eukaryotic cells must contend with a continuous stream of misfolded proteins that compromise the cellular protein homeostasis balance and jeopardize cell viability. An elaborate network of molecular chaperones and protein degradation factors continually monitor and maintain the integrity of the proteome. Cellular protein quality control relies on three distinct yet interconnected strategies whereby misfolded proteins can either be refolded, degraded, or delivered to distinct quality control compartments that sequester potentially harmful misfolded species. Molecular chaperones play a critical role in determining the fate of misfolded proteins in the cell. Here, we discuss the spatial and temporal organization of cellular quality control strategies and their implications for human diseases linked to protein misfolding and aggregation.
authors: Department of Biology and BioX Program, Stanford University, Stanford, California 94305, USA.
authors: Bryan
authors: B
authors: Chen
authors: Marco
authors: M
authors: Retzlaff
authors: Thomas
authors: T
authors: Roos
authors: Judith
authors: J
authors: Frydman
mesh_terms: D000686:Amyloidosis / Q000209:etiology; D000818:Animals; D006706:Homeostasis; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism*; D017510:Protein Folding; D020543:Proteome / Q000378:metabolism*
chemical_list: D018832:Molecular Chaperones; D020543:Proteome