title: Feasibility of MRI-guided high intensity focused ultrasound treatment for adenomyosis.
abstract: OBJECTIVE
  To test the feasibility of MRI-guided high intensity focused ultrasound ablation for adenomyosis.
  
  
  METHODS
  Patients with symptomatic adenomyosis were treated with MRI-guided high intensity focused ultrasound (MRIgHIFU). Under conscious sedation, MRIgHIFU was performed by a clinical MRI-compatible focused ultrasound tumour therapeutic system (JM15100, Haifu® Technology Co. Ltd., Chongqing, China) which is combined with a 1.5 T MRI system (Magnetom Symphony, Siemens Healthcare, Erlangen, Germany). MRI was used to calculate the volume of the uterus and lesion. Non-perfused volume of the targeted lesions was evaluated immediately after MRIgHIFU. Patient symptoms were assessed using symptom severity score (SSS) and uterine fibroids symptoms and quality of life questionnaire (UFS-QOL).
  
  
  RESULTS
  Ten patients with mean age of 40.3±4 years with an average lesion size of 56.9±12.7 mm in diameter were treated. Non-perfused volume and the percentage of non-perfused volume obtained from contrast-enhanced T1 Magnetic resonance images immediately post-treatment were 66.6±49.4 cm3 and 62.5±21.6%, respectively. The mean SSS and UFS-QOL showed significant improvements of 25%, 16% and 25% at 3, 6 and 12 months follow up, respectively, to pre-treatment scores. No serious complications were observed.
  
  
  CONCLUSIONS
  Based on the results from this study, MRIgHIFU treatment appears to be a safe and feasible modality to ablate adenomyosis lesion and alleviate its symptoms.
authors: State Key Laboratory of Ultrasound Engineering in Medicine, Department of Biomedical Engineering, Chongqing Medical University, Clinical Center of Tumor Therapy, 2nd Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors: Tien-Ying
authors: TY
authors: Fan
authors: Lian
authors: L
authors: Zhang
authors: Wenzhi
authors: W
authors: Chen
authors: Yinjiang
authors: Y
authors: Liu
authors: Min
authors: M
authors: He
authors: Xiu
authors: X
authors: Huang
authors: Franco
authors: F
authors: Orsi
authors: Zhibiao
authors: Z
authors: Wang
mesh_terms: D062788:Adenomyosis / Q000473:pathology* / Q000601:surgery*; D000328:Adult; D005240:Feasibility Studies; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome