title: A randomized double-blind placebo-controlled study of Pu'er tea extract on the regulation of metabolic syndrome.
abstract: OBJECTIVE
  To explore the regulative efficacy of Pu'er tea () extract on metabolic syndrome.
  
  
  METHODS
  Ninety patients with metabolic syndrome were randomly divided into two groups, the intervention group administered with Pu'er tea extract, and the placebo group with placebo capsules. After 3 months' treatment, body mass index, waist hip ratio, blood lipids, blood sugar, immune and inflammatory index, and oxidation index of the patients with metabolic syndrome were tested and analyzed.
  
  
  RESULTS
  In the intervention group, the body mass index, waist-hip ratio, fasting and 2 h postprandial blood glucose, serum total cholesterol, triglycerides, low density lipoprotein and apolipoprotein B-100 all decreased in the patients with metabolic syndrome, and also the high-density lipoprotein level increased and apolipoprotein A-1 showed the tendency to increase. Serum C-reactive protein, tumor necrosis factor-α, and interleukin-6 were decreased in the intervention group. Interleukin-10 level was increased, MDA was decreased and superoxide dismutase was increased. Compared with before treatment and the placebo group, there were significant differences (P<0.05, P<0.01).
  
  
  CONCLUSIONS
  Pu'er tea demonstrated excellent potential in improving central obesity, adjusting blood lipid, lowering blood sugar, regulating immunity and resisting oxidation. It can adjust the metabolic syndrome of different clinical phenotypes to different degrees, and is ideally fit for early prevention of metabolic syndrome.
authors: Integration of Chinese and Western Medicine Laboratory of the First Hospital, Graduate School of Integration of Chinese and Western Medicine, Beijing Medical University, Beijing 100034, China.
authors: Song-Ling
authors: SL
authors: Chu
authors: Hong
authors: H
authors: Fu
authors: Jin-Xia
authors: JX
authors: Yang
authors: Geng-Xin
authors: GX
authors: Liu
authors: Pan
authors: P
authors: Dou
authors: Liang
authors: L
authors: Zhang
authors: Peng-Fei
authors: PF
authors: Tu
authors: Xue-Mei
authors: XM
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D010084:Oxidation-Reduction; D010919:Placebos; D010936:Plant Extracts / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D008055:Lipids; D010919:Placebos; D010936:Plant Extracts; D008315:Malondialdehyde; D013482:Superoxide Dismutase