title: Correlation of trace elemental profiles in blood samples of Indian patients with leukoplakia and oral submucous fibrosis.
abstract: In order to ascertain possible correlation between alterations in trace elemental profile and the progression or regression of two most common potentially malignant disorders affecting oral cavity, namely oral submucous fibrosis and leukoplakia, blood from 60 patients from each group of patients as well from 30 healthy individuals was analyzed for elemental profiling employing EDXRF technique. Out of the 16 detected elements (K, Si, Ca, V, Cr, Ni, Mn, Fe, Cu, Zn, Se, Br, Rb, Sr, Co, and Pb), Mn, Fe, Zn, Br, and Co showed remarkable alteration in their profile in both leukoplakia and oral submucous fibrosis patients with respect to the normal healthy individuals. While Zn, Br, and Fe reflected similar changes--showing gross depletion in both the diseased groups, Mn and Co depicted inverse pattern of alterations in their concentrations in the two types of precancerous disorders when compared to the control subjects.
authors: Dr R Ahmed Dental College & Hospital, Kolkata, India.
authors: J G
authors: JG
authors: Ray
authors: Ranjan
authors: R
authors: Ghosh
authors: Debarati
authors: D
authors: Mallick
authors: Niharika
authors: N
authors: Swain
authors: Premdeep
authors: P
authors: Gandhi
authors: S S
authors: SS
authors: Ram
authors: S
authors: S
authors: Selvaraj
authors: A
authors: A
authors: Rathore
authors: Sudarshan
authors: S
authors: Mathummal
authors: Anindita
authors: A
authors: Chakraborty
mesh_terms: D000328:Adult; D018450:Disease Progression; D006801:Humans; D007194:India; D007971:Leukoplakia / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism; D009914:Oral Submucous Fibrosis / Q000378:metabolism*; D011230:Precancerous Conditions / Q000175:diagnosis / Q000378:metabolism; D013052:Spectrometry, X-Ray Emission; D014131:Trace Elements / Q000032:analysis / Q000097:blood* / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014131:Trace Elements