title: A case of anti-GA1 antibody-positive Fisher syndrome with elevated tau protein in cerebrospinal fluid.
abstract: We describe a boy with Fisher syndrome. He presented the typical symptoms of Fisher syndrome, including external ophthalmoplegia, abnormality of convergence, and areflexia, after an episode of Campylobacter enterocolitis. Atypically, however, anti-GA1 antibody was detected in his serum, though anti-GQ1b and anti-GT1a antibodies were not. In addition, the tau protein level in his cerebrospinal fluid was elevated. Generally, Fisher syndrome is a self-limiting disease and has a good prognosis. In our patient, however, mild diplopia and areflexia persisted 6 months after their onset. Here, we report on the first Fisher syndrome patient with anti-GA1 antibody in the serum and elevated tau protein in the cerebrospinal fluid.
authors: Department of Pediatrics, Kakogawa West City Hospital, Hyogo, Japan. ysnb.oyazato@gmail.com
authors: Yoshinobu
authors: Y
authors: Oyazato
authors: Takashi
authors: T
authors: Shiihara
authors: Susumu
authors: S
authors: Kusunoki
authors: Masao
authors: M
authors: Adachi
authors: Noriko
authors: N
authors: Ohnishi
authors: Hiroaki
authors: H
authors: Taniguchi
authors: Atsushi
authors: A
authors: Nishiyama
authors: Aika
authors: A
authors: Watanabe
authors: Mitsuro
authors: M
authors: Kobayashi
authors: Ichiro
authors: I
authors: Kamioka
mesh_terms: D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D020274:Autoimmune Diseases of the Nervous System / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000382:microbiology; D002169:Campylobacter Infections / Q000134:cerebrospinal fluid / Q000276:immunology; D002648:Child; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D019846:Miller Fisher Syndrome / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000382:microbiology; D015854:Up-Regulation / Q000276:immunology; D016875:tau Proteins / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D001323:Autoantibodies; C011258:G(A1) ganglioside; D005732:Gangliosides; D016875:tau Proteins