title: Core-APOBEC3C chimerical protein inhibits hepatitis B virus replication.
abstract: We tested the capsid targeted viral inactivation method as an anti-HBV strategy. HepG2 cells were cotransfected with HBV expression plasmid and the plasmid encoding fusion protein of either Core-A3C or Core-humanized renilla GFP (hrGFP). Core-A3C had substantial effect on HBV DNA levels. In the HepG2 cells expressing Core-A3C, the number of G-to-A mutations increased dramatically, whereas other nucleotide substitutions were rare. In addition, Core-A3C substantially inhibited HBV production intracellularly and in culture supernatant. These results suggest that Core-A3C may be a candidate as a novel antiviral agent against human HBV infection.
authors: Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, PR China.
authors: Dong
authors: D
authors: Li
authors: Jinxia
authors: J
authors: Liu
authors: Fubiao
authors: F
authors: Kang
authors: Weiwei
authors: W
authors: Guan
authors: Xiangcui
authors: X
authors: Gao
authors: Yuming
authors: Y
authors: Wang
authors: Dianxing
authors: D
authors: Sun
mesh_terms: D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism*; D006515:Hepatitis B virus / Q000378:metabolism*; D006801:Humans; D014779:Virus Replication
chemical_list: C495795:APOBEC3C protein, human; D003564:Cytidine Deaminase