title: Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study.
abstract: Even though recent studies suggest that a high intake of heme iron is associated with several types of cancer, epidemiological studies in relation to gastric cancer (GC) are lacking. Our previous results show a positive association between red and processed meat and non cardia gastric cancer, especially in Helicobacter pylori infected subjects. The aim of the study is to investigate the association between heme iron intake and GC risk in the European prospective investigation into cancer and nutrition (EURGAST-EPIC). Dietary intake was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat intake, derived from the literature. Antibodies of H. pylori infection and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control study within the cohort. The study included 481,419 individuals and 444 incident cases of GC that occurred during an average of 8.7 years of followup. We observed a statistically significant association between heme iron intake and GC risk (HR 1.13 95% CI: 1.01-1.26 for a doubling of intake) adjusted by sex, age, BMI, education level, tobacco smoking and energy intake. The positive association between heme iron and the risk of GC was statistically significant in subjects with plasma vitamin C <39 mmol/l only (log2 HR 1.54 95% CI (1.01-2.35). We found a positive association between heme iron intake and gastric cancer risk.
authors: Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, (ICO-IDIBELL) Barcelona, Spain. paujak@iconcologia.net
authors: Paula
authors: P
authors: Jakszyn
authors: Antonio
authors: A
authors: Agudo
authors: Leila
authors: L
authors: Lujan-Barroso
authors: H Bas
authors: HB
authors: Bueno-de-Mesquita
authors: Mazda
authors: M
authors: Jenab
authors: Carmen
authors: C
authors: Navarro
authors: Domenico
authors: D
authors: Palli
authors: Heiner
authors: H
authors: Boeing
authors: Jonas
authors: J
authors: Manjer
authors: Mattijs E
authors: ME
authors: Numans
authors: Laszlo
authors: L
authors: Igali
authors: Marie-Christine
authors: MC
authors: Boutron-Ruault
authors: Françoise
authors: F
authors: Clavel-Chapelon
authors: Sophie
authors: S
authors: Morois
authors: Sara
authors: S
authors: Grioni
authors: cSalvatore
authors: c
authors: Panico
authors: Rosario
authors: R
authors: Tumino
authors: Carlotta
authors: C
authors: Sacerdote
authors: J Ramon
authors: JR
authors: Quirós
authors: Esther
authors: E
authors: Molina-Montes
authors: Jose Ma
authors: JM
authors: Huerta Castaño
authors: Aurelio
authors: A
authors: Barricarte
authors: Pilar
authors: P
authors: Amiano
authors: Kay-Tee
authors: KT
authors: Khaw
authors: Nicholas
authors: N
authors: Wareham
authors: Naomi E
authors: NE
authors: Allen
authors: Timothy J
authors: TJ
authors: Key
authors: Suzanne M
authors: SM
authors: Jeurnink
authors: Petra H M
authors: PH
authors: Peeters
authors: Christina
authors: C
authors: Bamia
authors: Elisabeth
authors: E
authors: Valanou
authors: Antonia
authors: A
authors: Trichopoulou
authors: Rudolf
authors: R
authors: Kaaks
authors: Annekatrin
authors: A
authors: Lukanova
authors: Manuela M
authors: MM
authors: Bergmann
authors: Björn
authors: B
authors: Lindkvist
authors: Roger
authors: R
authors: Stenling
authors: Ingegerd
authors: I
authors: Johansson
authors: Christina C
authors: CC
authors: Dahm
authors: Kim
authors: K
authors: Overvad
authors: Anja
authors: A
authors: Olsen
authors: Anne
authors: A
authors: Tjonneland
authors: Guri
authors: G
authors: Skeie
authors: Ann Ragnhild
authors: AR
authors: Broderstad
authors: Eiliv
authors: E
authors: Lund
authors: Dominique S
authors: DS
authors: Michaud
authors: Traci
authors: T
authors: Mouw
authors: Elio
authors: E
authors: Riboli
authors: Carlos A
authors: CA
authors: González
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004032:Diet; D005060:Europe; D005260:Female; D006418:Heme / Q000008:administration & dosage*; D006801:Humans; D007501:Iron / Q000008:administration & dosage*; D008297:Male; D008460:Meat; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D013274:Stomach Neoplasms / Q000209:etiology*
chemical_list: D006418:Heme; D007501:Iron