title: [Diagnostic imaging of treatment in osteoporosis: PTH].
abstract: Parathyroid hormone (PTH [1-34]) stimulates bone formation and activates bone remodeling, resulting in increase of bone mass and strength. The effect on bone quality appears through the different mechanism from the anti-resorptive agents. The anti-resorptive agent maintains the trabecular microstructure, decreases the cortical porosity and increases the degree of mineralization, meanwhile, the anabolic agent such as PTH increases trabecular number and cortical thickness, decreases the mineralization and increases cortical porosity. Both different mechanisms of anti-resorptive and anabolic agents improve the biomechanical properties of bone. Micro-CT and clinical CT images demonstrate the effect of PTH on bone quality.
authors: Division of Radiology, Nagasaki University Hospital.
authors: Masako
authors: M
authors: Ito
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000648:ultrastructure; D002113:Calcification, Physiologic / Q000187:drug effects; D005260:Female; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D016062:Porosity / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic; D051381:Rats; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D010281:Parathyroid Hormone