title: Ubiquitylation and autophagy in the control of bacterial infections and related inflammatory responses.
abstract: The ubiquitin proteasome system and autophagy constitute key signalling pathways in the host response to infection. The identification of adaptors linking the two pathways has prompted a re-examination of the latter's involvement in inflammatory reactions and the clearance of bacteria. The ubiquitin-autophagy pathway is a preferred target for effectors from pathogens that seek to exploit and evade the host defence mechanisms. A number of new players and signalling nodes have recently been identified. Here, we discuss these new insights into the host's control of bacterial infection.
authors: Cellular Microbiology of Infectious Pathogens, Lille Center for Infection and Immunity, CNRS UMR8204, INSERM U1019, University of Lille Nord-de-France, Institut Pasteur de Lille, F-59019 Lille, France.
authors: Laure-Anne
authors: LA
authors: Ligeon
authors: Nassima
authors: N
authors: Temime-Smaali
authors: Frank
authors: F
authors: Lafont
mesh_terms: D000818:Animals; D001343:Autophagy / Q000276:immunology* / Q000502:physiology*; D001424:Bacterial Infections / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology; D054875:Ubiquitination / Q000502:physiology*