title: In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury.
abstract: For the first time, we have implemented photoacoustic tomography (PAT) to image the water content of an edema in vivo. We produced and imaged a cold-induced cerebral edema transcranially, then obtained blood vessel and water accumulation images at 610 and 975 nm, respectively. We tracked the changes at 12, 24, and 36 h after the cold injury. The blood volume decreased after the cold injury, and the maximum area of edema was observed 24 h after the cold injury. We validated PAT of the water content of the edema through magnetic Resonance Imaging and the water spectrum from the spectrophotometric measurement.
authors: Washington University, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130-4899, USA.
authors: Zhun
authors: Z
authors: Xu
authors: Quing
authors: Q
authors: Zhu
authors: Lihong V
authors: LV
authors: Wang
mesh_terms: D000465:Algorithms; D000818:Animals; D001923:Brain Chemistry; D001929:Brain Edema / Q000097:blood / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D003080:Cold Temperature / Q000009:adverse effects; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006454:Hemoglobins / Q000378:metabolism; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D010100:Oxygen / Q000097:blood; D014867:Water / Q000737:chemistry
chemical_list: D006454:Hemoglobins; D014867:Water; D010100:Oxygen