title: The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes.
abstract: The glutamatergic pathway has been consistently involved in the physiopathology of depressive disorder. However a complete dissection and integration of its role in the context of other known mechanisms is lacking. We summarized and integrated the evidence of various levels of interaction between glutamatergic and monoaminergic pathways (see videos). We identified six molecular pathways, some of which with specific regional distribution within the brain. From the six pathways we identified the key proteins and their coding genes, we then provided a detailed list of possible candidates with practical suggestions for association studies planning.
authors: Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy.
authors: Antonio
authors: A
authors: Drago
authors: Concetta
authors: C
authors: Crisafulli
authors: Antonina
authors: A
authors: Sidoti
authors: Alessandro
authors: A
authors: Serretti
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology / Q000503:physiopathology; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D003866:Depressive Disorder / Q000235:genetics* / Q000503:physiopathology*; D004298:Dopamine / Q000378:metabolism*; D018683:Excitatory Amino Acid Agents; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010641:Phenotype; D011493:Protein Kinase C / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D018683:Excitatory Amino Acid Agents; D011954:Receptors, Dopamine; D009569:Nitric Oxide; D012701:Serotonin; D018698:Glutamic Acid; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D020928:Mitogen-Activated Protein Kinases; D004298:Dopamine; D009638:Norepinephrine