title: 13C MR imaging of methionine-rich gliomas at 4.7T: a pilot study.
abstract: We explored the feasibility of using carbon-13 ((13)C) magnetic resonance imaging ((13)C-MRI) to depict (13)C-labeled methionine-enriched gliomas at 4.7 tesla. We transplanted 2 types of glioma cells separately to 2 subcutaneous tissue sites on the backs of mice weighing 15 to 20 g. After confirming tumor growth, we used (13)C-MRI and (1)H-MRI to scan 4 mice that had been administered (13)C-labeled methionine and 2 control mice. (13)C-MRI of all 4 transplanted mice administered with (13)C-labeled methionine revealed 2 areas of hyperintensity that corresponded to the tumor sites on (1)H-MR images, but no such areas were visualized in transplanted controls. Our data suggest that (13)C-MRI can show the accumulation of (13)C-labeled tracer by gliomas.
authors: Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. akiran_s2000@yahoo.co.jp
authors: Akira
authors: A
authors: Sasao
authors: Toshinori
authors: T
authors: Hirai
authors: Norio
authors: N
authors: Iriguchi
authors: Hideo
authors: H
authors: Nakamura
authors: Mareina
authors: M
authors: Kudo
authors: Ako
authors: A
authors: Sasao
authors: Yasuyuki
authors: Y
authors: Yamashita
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism*; D002247:Carbon Isotopes; D005240:Feasibility Studies; D005910:Glioma / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008715:Methionine / Q000378:metabolism; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D010865:Pilot Projects
chemical_list: D002247:Carbon Isotopes; D008715:Methionine