title: Hippocampal interneurons are abnormal in schizophrenia.
abstract: OBJECTIVE
  The cellular substrate of hippocampal dysfunction in schizophrenia remains unknown. We tested the hypothesis that hippocampal interneurons are abnormal in schizophrenia, but that the total number of hippocampal neurons in the pyramidal cell layer is normal.
  
  
  METHODS
  We collected whole hippocampal specimens of 13 subjects with schizophrenia and 20 matched healthy control subjects to study the number of all neurons, the somal volume of neurons, the number of somatostatin- and parvalbumin-positive interneurons and the messenger RNA levels of somatostatin, parvalbumin and glutamic acid decarboxylase 67.
  
  
  RESULTS
  The total number of hippocampal neurons in the pyramidal cell layer was normal in schizophrenia, but the number of somatostatin- and parvalbumin-positive interneurons, and the level of somatostatin, parvalbumin and glutamic acid decarboxylase mRNA expression were reduced.
  
  
  CONCLUSIONS
  The study provides strong evidence for a specific defect of hippocampal interneurons in schizophrenia and has implications for emerging models of hippocampal dysfunction in schizophrenia.
authors: Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-8548, USA. christine.konradi@vanderbilt.edu
authors: Christine
authors: C
authors: Konradi
authors: C Kevin
authors: CK
authors: Yang
authors: Eric I
authors: EI
authors: Zimmerman
authors: Kathryn M
authors: KM
authors: Lohmann
authors: Paul
authors: P
authors: Gresch
authors: Harry
authors: H
authors: Pantazopoulos
authors: Sabina
authors: S
authors: Berretta
authors: Stephan
authors: S
authors: Heckers
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D016022:Case-Control Studies; D002452:Cell Count; D005260:Female; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000145:classification / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D010320:Parvalbumins / Q000235:genetics / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy / Q000473:pathology*; D013004:Somatostatin / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D010320:Parvalbumins; D013004:Somatostatin; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1