title: Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy.
abstract: Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrate the potential of endoglin in tumor diagnosis, prognosis, and therapy. This review details the structure and function of endoglin, and investigates the role of endoglin in angiogenesis and tumor diagnosis, prognosis, and therapy.
authors: Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, M5B1W8, Canada.
authors: Farshad
authors: F
authors: Nassiri
authors: Michael D
authors: MD
authors: Cusimano
authors: Bernd W
authors: BW
authors: Scheithauer
authors: Fabio
authors: F
authors: Rotondo
authors: Alessandra
authors: A
authors: Fazio
authors: George M
authors: GM
authors: Yousef
authors: Luis V
authors: LV
authors: Syro
authors: Kalman
authors: K
authors: Kovacs
authors: Ricardo V
authors: RV
authors: Lloyd
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D000071063:Endoglin; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface