title: Immunohistochemical application of S100A1 in renal oncocytoma, oncocytic papillary renal cell carcinoma, and two variants of chromophobe renal cell carcinoma.
abstract: S100A1 is a calcium-binding protein and a member of the S100 family. Recently, S100A1 immunohistochemistry may be an available marker in the differential diagnosis between renal oncocytoma and chromophobe renal cell carcinoma (RCC). However, there are no reports on S100A1 expression in oncocytic papillary RCC that has been recently identified. In this article, we immunohistochemically examined the expression of S100A1 protein in 18 renal tumors including 4 renal oncocytoma, 10 chromophobe RCCs, and 4 oncocytic papillary RCCs. All the cases of renal oncocytoma and oncocytic papillary RCC showed a positive reaction for S100A1 with cytoplasmic pattern. In chromophobe RCC, 3 of 4 tumors with typical variant and 4 of 6 tumors in eosinophilic variant were completely negative for S100A1. Finally, S100A1 immunohistochemistry may be useful in distinguishing renal oncocytoma from chromophobe RCC, but it may be of no use in the differential diagnosis between renal oncocytoma and oncocytic papillary RCC.
authors: Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2-13-51 Shin-honmachi, Kochi, 780-8562, Japan. kurochankochi@yahoo.co.jp
authors: Naoto
authors: N
authors: Kuroda
authors: Naoki
authors: N
authors: Kanomata
authors: Tadanori
authors: T
authors: Yamaguchi
authors: Yoshiaki
authors: Y
authors: Imamura
authors: Chisato
authors: C
authors: Ohe
authors: Noriko
authors: N
authors: Sakaida
authors: Ondrej
authors: O
authors: Hes
authors: Michal
authors: M
authors: Michal
authors: Taro
authors: T
authors: Shuin
authors: Gang-Hong
authors: GH
authors: Lee
mesh_terms: D018249:Adenoma, Oxyphilic / Q000175:diagnosis / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis* / Q000276:immunology
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins; C110294:S100A1 protein