title: Interleukin-22 protects against acute alcohol-induced hepatotoxicity in mice.
abstract: The protective effects of interleukin-22 (IL-22) on acute alcohol-induced liver injury were investigated. Mice were gavaged with 7 doses of alcohol (56% wt/vol, 15.2 mL/kg of body weight for each dose) over the 24 h, and IL-22 (0.5 mg/kg BW) was given to the mice by injection into the tail vein 1 h after alcohol administration. The results indicated that acute alcohol administration caused prominent hepatic microvesicular steatosis and an elevation of serum transaminase activities, induced a significant decrease in hepatic glutathione in conjunction with enhanced lipid peroxidation, and increased hepatocyte apoptosis as well as hepatic TNF-alpha production. IL-22 treatment attenuated these adverse changes induced by acute alcohol administration. The protective effects of IL-22 on alcohol-induced hepatotoxicity were due mainly to its anti-inflammatory, anti-oxidant, and anti-apoptotic features.
authors: Beijing Institute of Basic Medical Sciences, Beijing, PR China.
authors: Wei-Wei
authors: WW
authors: Xing
authors: Min-Ji
authors: MJ
authors: Zou
authors: Shen
authors: S
authors: Liu
authors: Tao
authors: T
authors: Xu
authors: Jia-Xi
authors: JX
authors: Wang
authors: Dong-Gang
authors: DG
authors: Xu
mesh_terms: D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D005235:Fatty Liver, Alcoholic / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D006519:Hepatitis, Alcoholic / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D007249:Inflammation; D007378:Interleukins / Q000008:administration & dosage*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects* / Q000378:metabolism; D000097043:Interleukin-22
chemical_list: D000410:Alanine Transaminase; D000975:Antioxidants; D000431:Ethanol; D005978:Glutathione; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D000097043:Interleukin-22