title: Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer.
abstract: Forkhead box O3 (FOXO3) has a wide range of functions: it promotes tumor suppression, cell cycle arrest, repair of damaged DNA, detoxification of reactive oxygen species, apoptosis and plays a pivotal role in promoting longevity. FOXO3 is a key downstream target of the PI3K-Akt pathway in response to cellular stimulation by growth factors or insulin and has been proposed as a bridge between ageing and tumor suppression. Three SNPs in the FOXO3 gene (rs3800231, rs9400239 and rs479744) that have been shown to be strongly and consistently associated with longevity, were examined in relation to PC risk in a case control study of 1571 incident PC cases and 1840 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). There was no statistically significant association between the SNPs and PC risk regardless of the model of inheritance (dominant, codominant and recessive). The associations were not modified by disease aggressiveness, circulating levels of steroid sex hormones, or IGFs or BMI. We conclude that polymorphisms in the FOXO3 gene that are associated with longevity are not major risk factors for PC risk, in this population of Caucasian men.
authors: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
authors: Daniele
authors: D
authors: Campa
authors: Anika
authors: A
authors: Hüsing
authors: Lucie
authors: L
authors: Dostal
authors: Angelika
authors: A
authors: Stein
authors: Dagmar
authors: D
authors: Drogan
authors: Heiner
authors: H
authors: Boeing
authors: Anne
authors: A
authors: Tjønneland
authors: Nina
authors: N
authors: Roswall
authors: Jane Nautrup
authors: JN
authors: Østergaard
authors: Kim
authors: K
authors: Overvad
authors: Laudina
authors: L
authors: Rodríguez
authors: Catalina
authors: C
authors: Bonet
authors: Maria-José
authors: MJ
authors: Sánchez
authors: Nerea
authors: N
authors: Larrañaga
authors: José María
authors: JM
authors: Huerta
authors: Eva
authors: E
authors: Ardanaz
authors: Kay-Tee
authors: KT
authors: Khaw
authors: Nicholas
authors: N
authors: Wareham
authors: Ruth C
authors: RC
authors: Travis
authors: Naomi E
authors: NE
authors: Allen
authors: Antonia
authors: A
authors: Trichopoulou
authors: Dimosthenis
authors: D
authors: Zylis
authors: Tina
authors: T
authors: Karapetyan
authors: Domenico
authors: D
authors: Palli
authors: Sabina
authors: S
authors: Sieri
authors: Rosario
authors: R
authors: Tumino
authors: Paolo
authors: P
authors: Vineis
authors: H Bas
authors: HB
authors: Bueno-de-Mesquita
authors: Per
authors: P
authors: Lenner
authors: Mattias
authors: M
authors: Johansson
authors: Mazda
authors: M
authors: Jenab
authors: David
authors: D
authors: Cox
authors: Afshan
authors: A
authors: Siddiq
authors: Rudolf
authors: R
authors: Kaaks
authors: Federico
authors: F
authors: Canzian
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005060:Europe / Q000453:epidemiology; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D015398:Signal Transduction; D044465:White People
chemical_list: C499517:FOXO3 protein, human; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors