title: Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus.
abstract: OBJECTIVE
  Exercise may be useful to detect patients with diabetes prone to develop persistent microalbuminuria. We studied the relationship between exercise intensity, measured as maximal oxygen consumption (VO(2)max), and microalbuminuria in patients with Type 1 diabetes mellitus patients.
  
  
  METHODS
  We studied 10 patients, age range 10-18 years, with Type 1 diabetes who were normotensive and normoalbuminuric, with less than 10 years since diagnosis. Patients had normal renal function, without infections or clinical evidence of complications. Metabolic control was intensively adjusted in all patients. They underwent three consecutive physical exercise tests, reaching 100, 80 and 60% of the maximal cardiac frequency response.
  
  
  RESULTS
  Eight patients had adequate to regular metabolic control. All patients had lower than predicted VO(2)max values. At 60%, only three patients showed microalbuminuria in excess of 20 μg/min, two of them had inadequate metabolic control. Post-exercise microalbuminuria exceeded normal values in nine, seven and three patients when submitted to 100, 80 and 60% of exercise intensity, respectively.
  
  
  CONCLUSIONS
  Microalbuminuria increased with exercise intensity. Sex, body composition and VO(2)max were the main factors associated with microalbuminuria. The prognostic significance of albuminuria induced by intense exercise in these subjects with Type 1 diabetes is not yet known.
authors: Departamento de Ciencias Médicas División de Ciencias de la Salud, Universidad de Guanajuato, León, México. carloskornhauser@yahoo.com.mx
authors: C
authors: C
authors: Kornhauser
authors: J-M
authors: JM
authors: Malacara
authors: M-H
authors: MH
authors: Macías-Cervantes
authors: A-E
authors: AE
authors: Rivera-Cisneros
mesh_terms: D000293:Adolescent; D000419:Albuminuria / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001823:Body Composition; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D004562:Electrocardiography; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D011237:Predictive Value of Tests; D017678:Sex Distribution; D013997:Time Factors
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin