title: Polymorphisms in the 5-HTR2A gene related to obstructive sleep apnea syndrome.
abstract: Obstructive sleep apnea syndrome (OSAS) is one of the most complex disorders of sleep; it involves several genetic factors that contribute to the phenotype. Serotonin (5-HT) regulates a variety of visceral and physiological functions, including sleep. Gene 5-HTR2A polymorphisms may change the transcription of several receptors in the serotoninergic system, thereby contributing to OSAS.
  
  
  OBJECTIVE
  To investigate the prevalence of T102C and -1438G/A polymorphisms in the 5-HTR2A gene of patients with and without OSAS.
  
  
  METHODS
  A molecular study of 100 index-cases and 100 controls of both genders. DNA was extracted from blood leukocytes samples and the regions that enclose both polymorphisms were amplified with PCR-RFLP.
  
  
  METHODS
  A cross-sectional case study.
  
  
  RESULTS
  There was a significant prevalence of males in index cases compared to controls (p<0.0001). No significant genotypic differences between cases and controls were found in T102C polymorphisms (p=1.000).There were significant differences between the AA genotype of -1438G/A polymorphisms and patients with OSAS (OR:2.3; CI95%:1.20-4.38, p=0.01).
  
  
  CONCLUSIONS
  Serotonergic mechanisms may be related to OSAS. There were no differences in the prevalence of T102C polymorphisms in patients with OSAS and the control group. There is evidence of an association between the -1438G /A polymorphism and OSAS.
authors: Otorhinolaryngology and Head & Neck Surgery Department, FAMERP. vbpiatto@gmail.com
authors: Vânia Belintani
authors: VB
authors: Piatto
authors: Thiago Bittencourt Ottoni de
authors: TB
authors: Carvalho
authors: Nely Silva Aragão
authors: NS
authors: De Marchi
authors: Fernando Drimel
authors: FD
authors: Molina
authors: José Victor
authors: JV
authors: Maniglia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000235:genetics*; D055815:Young Adult
chemical_list: D044402:Receptor, Serotonin, 5-HT2A