title: Nitric oxide and cyclic GMP signaling pathway as a focus for drug development.
abstract: Recent progress in understanding of the nitric oxide and cGMP signaling pathway provided evidence for mechanism of action of known drugs and identified novel targets for drug development. These discoveries resulted in numerous efforts in drug and formulation discovery. Some of the most promising approaches were applied for efficient therapies of various diseases.
authors: Department of Biochemistry and Molecular Biology, George Washington University School of Medicine, 2300 Eye Street NW, Ross Hall 530, Washington DC 20052, USA. aykots@gmail.com
authors: A Y
authors: AY
authors: Kots
authors: K
authors: K
authors: Bian
authors: F
authors: F
authors: Murad
mesh_terms: D006152:Cyclic GMP / Q000378:metabolism*; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D009569:Nitric Oxide / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D009569:Nitric Oxide; D006152:Cyclic GMP