title: Genetic testing for lynch syndrome in individuals newly diagnosed with colorectal cancer to reduce morbidity and mortality from colorectal cancer in their relatives.
abstract: Individuals with Lynch syndrome, sometimes referred to as hereditary non-polyposis colorectal cancer (HNPCC), have an increased risk of developing colorectal cancer (CRC) as well as other cancers. The increased risk is due to inherited mutations in mismatch repair (MMR) genes, which reduce the ability of cells to repair DNA damage. Screening for Lynch syndrome in individuals newly diagnosed with colorectal cancer has been proposed as part of a strategy that combines tests and interventions to reduce the risk of colorectal cancer in the relatives of the colorectal cancer patients with Lynch Syndrome.
authors: Associate Director for Science, Public Health Surveillance Program Office, Centers for Disease Control and Prevention; Director, Intermountain Healthcare Clinical Genetics Institute; Office of Public Health Genomics, Centers for Disease Control and Prevention and Health services research, focus in clinical genetics.
authors: Ralph
authors: R
authors: Coates
authors: Marc
authors: M
authors: Williams
authors: Stephanie
authors: S
authors: Melillo
authors: Jim
authors: J
authors: Gudgeon