title: Effect of a dual drug-coated stent with abciximab and alpha-lipoic Acid in a porcine coronary restenosis model.
abstract: OBJECTIVE
  The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of a stent coated with abciximab and alpha-lipoic acid (ALA) in a porcine coronary overstretch restenosis model.
  
  
  METHODS
  A total of 10 pigs were randomized into two groups (10 pigs, 10 coronaries in each group) in which the coronary arteries were stented with a dual-coated stent and a bare metal stent (control) by randomization. Stents were deployed with oversizing (stent/artery ratio 1.3 : 1) in the porcine coronary arteries, and histopathology was assessed 28 days after stenting.
  
  
  RESULTS
  There was no significant difference in the injury score between the two groups. In the neointima, the lymphohistiocyte count was significantly lower in dual-coat stent group compared with the control stent group (120±85 cells vs. 159±80 cells, p=0.048). There was no significant difference in the fibrin score between the two groups (0.16±0.34 in the dual-coated stent group vs. 0.25±0.48 in the control stent group, p=0.446). The neointima area was not significantly different between both groups (1.55±0.8 mm(2) in dual-coated stent group vs. 1.40±0.86 mm(2) in the control stent group, p=0.447).
  
  
  CONCLUSIONS
  Although the dual-coated stent with abciximab and ALA showed no significant difference in inhibition of neointimal hyperplasia when compared with the bare metal stent, it was associated with a reduced inflammatory reaction when compared with the control stent in a porcine coronary restenosis model.
authors: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju, Korea.
authors: Kyung Seob
authors: KS
authors: Lim
authors: Young Joon
authors: YJ
authors: Hong
authors: Daisuke
authors: D
authors: Hachinohe
authors: Khurshid
authors: K
authors: Ahmed
authors: Myung Ho
authors: MH
authors: Jeong
authors: Jung Ha
authors: JH
authors: Kim
authors: Doo Sun
authors: DS
authors: Sim
authors: Min Goo
authors: MG
authors: Lee
authors: Keun-Ho
authors: KH
authors: Park
authors: Ju Han
authors: JH
authors: Kim
authors: Youngkeun
authors: Y
authors: Ahn
authors: Jeong Gwan
authors: JG
authors: Cho
authors: Jong Chun
authors: JC
authors: Park
authors: Sun-Jung
authors: SJ
authors: Song
authors: Kyoung Woon
authors: KW
authors: Jung
authors: Dong Lyun
authors: DL
authors: Cho
authors: Jung Chaee
authors: JC
authors: Kang