title: Association between the GIPR gene and the insulin level after glucose loading in schizophrenia patients treated with olanzapine.
abstract: Several studies have shown increased rates of hyperglycemia and diabetes in schizophrenic patients treated with olanzapine. However, the underlying mechanism is poorly understood. Glucose-dependent insulinotropic polypeptide (GIP) is known to affect insulin secretion by pancreatic β cells. Recently, a meta-analysis study reported an association between a GIP receptor (GIPR) gene polymorphism (rs10423928) and insulin secretion measured by an oral glucose tolerance test (OGTT). We assessed the influence of this GIPR gene polymorphism on glucose metabolism in 60 schizophrenic patients treated with olanzapine and 103 healthy controls. The GIPR gene polymorphism was determined using TaqMan methods. We performed repeated-measures analysis of variance (ANOVA) and one-way ANOVA for the glucose and insulin levels during OGTTs in four groups divided by the GIPR gene polymorphism and cohort (schizophrenia or control). We found significant effects of the GIPR gene and cohort on the insulin levels at 30 min. Our findings suggest that schizophrenic patients with the A allele of GIPR rs10423928 are at risk of developing hyperinsulinemia when treated with antipsychotics.
authors: Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors: S
authors: S
authors: Ono
authors: Y
authors: Y
authors: Suzuki
authors: N
authors: N
authors: Fukui
authors: T
authors: T
authors: Sugai
authors: J
authors: J
authors: Watanabe
authors: N
authors: N
authors: Tsuneyama
authors: T
authors: T
authors: Someya
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D019540:Area Under Curve; D001569:Benzodiazepines / Q000009:adverse effects*; D002096:C-Peptide / Q000097:blood; D005260:Female; D005838:Genotype; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D011110:Polymorphism, Genetic; D011964:Receptors, Gastrointestinal Hormone / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D002096:C-Peptide; D007328:Insulin; D011964:Receptors, Gastrointestinal Hormone; D001569:Benzodiazepines; C041086:gastric inhibitory polypeptide receptor; D000077152:Olanzapine