title: Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients.
abstract: OBJECTIVE
  To evaluate the association between prehospitalization aspirin therapy and incident acute lung injury in a heterogeneous cohort of at-risk medical patients.
  
  
  METHODS
  This is a secondary analysis of a prospective multicenter international cohort investigation.
  
  
  METHODS
  Multicenter observational study including 20 US hospitals and two hospitals in Turkey.
  
  
  METHODS
  Consecutive, adult, nonsurgical patients admitted to the hospital with at least one major risk factor for acute lung injury.
  
  
  METHODS
  None.
  
  
  RESULTS
  Baseline characteristics and acute lung injury risk factors/modifiers were identified. The presence of aspirin therapy and the propensity to receive this therapy were determined. The primary outcome was acute lung injury during hospitalization. Secondary outcomes included intensive care unit and hospital mortality and intensive care unit and hospital length of stay. Twenty-two hospitals enrolled 3855 at-risk patients over a 6-month period. Nine hundred seventy-six (25.3%) were receiving aspirin at the time of hospitalization. Two hundred forty (6.2%) patients developed acute lung injury. Univariate analysis noted a reduced incidence of acute lung injury in those receiving aspirin therapy (odds ratio [OR], 0.65; 95% confidence interval [CI], 0.46-0.90; p = .010). This association was attenuated in a stratified analysis based on deciles of aspirin propensity scores (Cochran-Mantel-Haenszel pooled OR, 0.70; 95% CI, 0.48-1.03; p = .072).
  
  
  CONCLUSIONS
  After adjusting for the propensity to receive aspirin therapy, no statistically significant associations between prehospitalization aspirin therapy and acute lung injury were identified; however, a prospective clinical trial to further evaluate this association appears warranted.
authors: Division of Critical Care, Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA.
authors: Daryl J
authors: DJ
authors: Kor
authors: Jason
authors: J
authors: Erlich
authors: Michelle N
authors: MN
authors: Gong
authors: Michael
authors: M
authors: Malinchoc
authors: Rickey E
authors: RE
authors: Carter
authors: Ognjen
authors: O
authors: Gajic
authors: Daniel S
authors: DS
authors: Talmor
mesh_terms: D055371:Acute Lung Injury / Q000517:prevention & control*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000008:administration & dosage*; D015897:Comorbidity; D017558:Elective Surgical Procedures / Q000706:statistics & numerical data*; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin