title: Traversing the NPC along the pore membrane: targeting of membrane proteins to the INM.
abstract: The inner nuclear membrane (INM) accommodates a specific set of integral membrane proteins many of which interact with chromatin and/or in metazoan cells with the lamina network. The localization of these proteins characterizes this membrane area of the nuclear envelope (NE) despite the fact that the INM forms a membrane continuum with the outer nuclear membrane (ONM) and the remaining endoplasmic reticulum (ER). In fact, the INM can be regarded as a highly specialized membrane subdomain of the ER. How the specific protein composition of the INM is established and maintained and whether this is achieved via a single unifying mechanism is by and large unclear. Recent experiments shed light on some aspects of the process.
authors: Friedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany. wolfram.antonin@tuebingen.mpg.de
authors: Wolfram
authors: W
authors: Antonin
authors: Rosemarie
authors: R
authors: Ungricht
authors: Ulrike
authors: U
authors: Kutay
mesh_terms: D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D022022:Nuclear Pore / Q000378:metabolism*; D011485:Protein Binding; D021381:Protein Transport
chemical_list: D008565:Membrane Proteins