title: Clinical correlates of white matter blood flow perfusion changes in Sturge-Weber syndrome: a dynamic MR perfusion-weighted imaging study.
abstract: OBJECTIVE
  Low brain tissue perfusion due to abnormal venous drainage is thought to be a central mechanism of brain damage in SWS. Here, HR-PWI was used to quantify WM perfusion abnormalities and to correlate these with brain atrophy and clinical variables.
  
  
  METHODS
  Fourteen children (age range, 0.8-10.0 years) with unilateral SWS underwent MR imaging examinations, including HR-PWI. rCBV, rCBF, and MTT in the affected WM and in contralateral homotopic WM were measured. AI for each perfusion parameter was correlated with age, brain atrophy, and motor and seizure variables as well as IQ.
  
  
  RESULTS
  Increased perfusion was seen in the affected hemisphere in 5 children and decreased perfusion in 9 children. Brain atrophy was more severe in the low-perfusion group (P = .01) and was related to both CBF-AI and CBV-AI (r = -0.69, P = .007; r = -0.64, P = .014, respectively). Older children had lower CBV values on the affected side (r = -0.62, P = .02). Longer duration of epilepsy was related to lower CBF (more negative CBF-AI, r = -0.58, P = .03) and low CBV (r = -0.55, P = .04) on the affected side. Lower perfusion was associated with more frequent seizures (rCBF-AI: r = -0.56, P = .04; rCBV-AI: r = -0.63, P = .02).
  
  
  CONCLUSIONS
  Increased perfusion in the affected cerebral WM may indicate an early stage of SWS without severe brain atrophy. Decreased perfusion is associated with frequent seizures, long duration of epilepsy, and brain atrophy.
authors: Department of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China.
authors: Y
authors: Y
authors: Miao
authors: C
authors: C
authors: Juhász
authors: J
authors: J
authors: Wu
authors: B
authors: B
authors: Tarabishy
authors: Z
authors: Z
authors: Lang
authors: M E
authors: ME
authors: Behen
authors: Z
authors: Z
authors: Kou
authors: Y
authors: Y
authors: Ye
authors: H T
authors: HT
authors: Chugani
authors: J
authors: J
authors: Hu
mesh_terms: D001284:Atrophy; D001921:Brain / Q000098:blood supply / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D056784:Leukoencephalopathies / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008297:Male; D008955:Models, Cardiovascular; D010291:Paresis / Q000473:pathology / Q000503:physiopathology; D055420:Perfusion Imaging / Q000379:methods* / Q000592:standards; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013341:Sturge-Weber Syndrome / Q000473:pathology* / Q000503:physiopathology