title: Differences in serum levels of CB-153 and p,p'-DDE, and reproductive parameters between men living south and north in Norway.
abstract: Arctic is contaminated with persistent organochlorine pollutants (POPs), and exposure to these compounds may differ between south and north in Norway. POPs may have negative impact on male reproductive characteristics. We compared serum levels of the CB-153 and p,p'-DDE in men who were born and had lived most of their lifetime south and north (close to or above the Arctic Circle) in Norway. We found no geographical differences in levels of CB-153 (south: 50 ng/g lipid (mean), north: 59 ng/g lipid; p=0.27) or sperm parameters. However, the levels of p,p'-DDE were higher in south than in north (81 ng/g lipid (mean) vs. 66 ng/g lipid; p=0.02), as were the levels of total and free testosterone. The FSH levels were lowest in south. A strong relationship between the CB-153 and the SHBG levels was observed. The regional differences observed for p,p'-DDE, testosterone and FSH were not reflected in the semen quality.
authors: Faculty of Health Sciences, Oslo University College, PO Box 4 St. Olavs plass, N-0130 Oslo, Norway. trine.b.haugen@hf.hio.no
authors: Trine B
authors: TB
authors: Haugen
authors: Toril
authors: T
authors: Tefre
authors: Gunilla
authors: G
authors: Malm
authors: Bo A G
authors: BA
authors: Jönsson
authors: Lars
authors: L
authors: Rylander
authors: Lars
authors: L
authors: Hagmar
authors: Cathrine
authors: C
authors: Bjørsvik
authors: Trine
authors: T
authors: Henrichsen
authors: Thomas
authors: T
authors: Sæther
authors: Yngve
authors: Y
authors: Figenschau
authors: Aleksander
authors: A
authors: Giwercman
mesh_terms: D000328:Adult; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009664:Norway; D011078:Polychlorinated Biphenyls / Q000097:blood*; D012098:Reproduction; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013076:Sperm Count; D013081:Sperm Motility; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D012738:Sex Hormone-Binding Globulin; C422364:inhibin B; D013739:Testosterone; D003633:Dichlorodiphenyl Dichloroethylene; D004958:Estradiol; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011078:Polychlorinated Biphenyls; C014024:2,4,5,2',4',5'-hexachlorobiphenyl