title: Lysosomal and lipid-associated parameters in the livers of three species of arctic seabird chicks: species differences and relationships with contaminant levels.
abstract: Lysosomal membrane stability, lipofuscin (LF), malondialdehyde (MDA), neutral lipid (NL) levels, as well as halogenated organic compounds (HOCs), Cr, Cd, Pb and Fe concentrations were analyzed in liver of black-legged kittiwake (BK), herring gull (HG), and northern fulmar (NF) chicks. There were significant species differences in the levels of NL, LF and lysosomal membrane stability. These parameters were not associated with the respective HOC concentrations. LF accumulation was associated with increasing Cr, Cd and Pb concentrations. HG presented the lowest lysosomal membrane stability and the highest. LF and NL levels, which indicated impaired lysosomes in HG compared to NF and BK. Lipid peroxidation was associated with HOC and Fe2+ levels. Specific HOCs showed positive and significant correlations with MDA levels in HG. The study indicates that contaminant exposure can affect lysosomal and lipid associated parameters in seabird chicks even at low exposure levels. These parameters may be suitable markers of contaminant induced stress in arctic seabirds.
authors: Akvaplan-NIVA AS, Fram Centre-High North Research Centre for Climate and the Environment, 9296 Tromsø, Norway. marit@akvaplan.niva.no
authors: Marit Nøst
authors: MN
authors: Hegseth
authors: Francesco
authors: F
authors: Regoli
authors: Stefania
authors: S
authors: Gorbi
authors: Raffaella
authors: R
authors: Bocchetti
authors: Geir Wing
authors: GW
authors: Gabrielsen
authors: Lionel
authors: L
authors: Camus
mesh_terms: D000818:Animals; D001110:Arctic Regions; D001717:Birds; D046091:Charadriiformes / Q000145:classification / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods*; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism*; D008670:Metals / Q000378:metabolism / Q000633:toxicity; D009930:Organic Chemicals / Q000378:metabolism / Q000633:toxicity; D013045:Species Specificity; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000633:toxicity*
chemical_list: D008670:Metals; D009930:Organic Chemicals; D014874:Water Pollutants, Chemical