title: Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones.
abstract: Dihydropyrimidones are an important class of biologically active heterocycles accessible from the multicomponent Biginelli condensation. Further manipulation of the dihydropyrimidone skeleton gives access to unique heterocycles. Presented herein is a Au-catalyzed cyclization of alkyne-tethered dihydropyrimidones to yield pyridopyrimidones.
authors: Department of Chemistry and Center for Chemical Methodology and Library Development, Life Sciences and Engineering Building, Boston University, 24 Cummington Street, Boston, Massachusetts 02215, USA.
authors: Lauren E
authors: LE
authors: Brown
authors: Peng
authors: P
authors: Dai
authors: John A
authors: JA
authors: Porco
authors: Scott E
authors: SE
authors: Schaus
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D011744:Pyrimidinones / Q000737:chemistry*
chemical_list: D000480:Alkynes; D011744:Pyrimidinones; D006046:Gold