title: Biochemistry of the non-mevalonate isoprenoid pathway.
abstract: The non-mevalonate pathway of isoprenoid (terpenoid) biosynthesis is essential in many eubacteria including the major human pathogen, Mycobacterium tuberculosis, in apicomplexan protozoa including the Plasmodium spp. causing malaria, and in the plastids of plants. The metabolic route is absent in humans and is therefore qualified as a promising target for new anti-infective drugs and herbicides. Biochemical and structural knowledge about all enzymes involved in the pathway established the basis for discovery and development of inhibitors by high-throughput screening of compound libraries and/or structure-based rational design.
authors: Department Chemie, Lehrstuhl für Biochemie, Center for Integrated Protein Science München, Technische Universität München, Garching, Germany.
authors: Tobias
authors: T
authors: Gräwert
authors: Michael
authors: M
authors: Groll
authors: Felix
authors: F
authors: Rohdich
authors: Adelbert
authors: A
authors: Bacher
authors: Wolfgang
authors: W
authors: Eisenreich
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D053898:Biosynthetic Pathways / Q000187:drug effects / Q000235:genetics; D023281:Genomics; D006540:Herbicides / Q000494:pharmacology; D006801:Humans; D008798:Mevalonic Acid; D008958:Models, Molecular; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D006540:Herbicides; D013729:Terpenes; D008798:Mevalonic Acid