title: Acinetobacter calcoaceticus-Acinetobacter baumannii complex species in clinical specimens in Singapore.
abstract: This study was performed to determine the prevalence, distribution of specimen sources, and antimicrobial susceptibility of the Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) species complex in Singapore. One hundred and ninety-three non-replicate Acb species complex clinical isolates were collected from six hospitals over a 1-month period in 2006. Of these, 152 (78·7%) were identified as A. baumannii, 18 (9·3%) as 'Acinetobacter pittii' [genomic species (gen. sp.) 3], and 23 (11·9%) as 'Acinetobacter nosocomialis' (gen. sp. 13TU). Carbapenem resistance was highest in A. baumannii (72·4%), followed by A. pittii (38·9%), and A. nosocomialis (34·8%). Most carbapenem-resistant A. baumannii and A. nosocomialis possessed the bla(OXA-23-like) gene whereas carbapenem-resistant A. pittii possessed the bla(OXA-58-like) gene. Two imipenem-resistant strains (A. baumannii and A. pittii) had the bla(IMP-like) gene. Representatives of carbapenem-resistant A. baumannii were related to European clones I and II.
authors: Department of Pathology, Singapore General Hospital, Singapore. koh.tse.hsien@sgh.com.sg
authors: T H
authors: TH
authors: Koh
authors: T T
authors: TT
authors: Tan
authors: C T
authors: CT
authors: Khoo
authors: S Y
authors: SY
authors: Ng
authors: T Y
authors: TY
authors: Tan
authors: L-Y
authors: LY
authors: Hsu
authors: E E
authors: EE
authors: Ooi
authors: T J K
authors: TJ
authors: Van Der Reijden
authors: L
authors: L
authors: Dijkshoorn
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000302:isolation & purification*; D016954:Acinetobacter calcoaceticus / Q000187:drug effects / Q000302:isolation & purification*; D015780:Carbapenems / Q000494:pharmacology; D016000:Cluster Analysis; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D006761:Hospitals; D006801:Humans; D058889:Molecular Typing; D015995:Prevalence; D012846:Singapore / Q000453:epidemiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D015780:Carbapenems; D001618:beta-Lactamases