title: [Mobile biosensor-based gait analysis: a diagnostic and therapeutic tool in Parkinson's disease].
abstract: Parkinson's disease (PD) is characterized by progressive motor and non-motor symptoms, leading to distinct diagnostic and therapeutic challenges in all stages of the disease. This study investigated a mobile biosensor-based gait analysis system for patients in early and intermediate stages of PD compared to controls. Subjects wearing a motion sensor-equipped shoe performed a standardized gait exercise. Accelerometer- and gyroscope-based signals were analysed using a complex set of pattern recognition algorithms. The analysis was able (1) to distinguish between PD patients and controls, (2) to identify patients at an early stage of the disease and (3) to distinguish between early and intermediate stage patients. Thus, using this mobile biosensor-based analysis system we were able to obtain objective classifications of gait characteristics in PD. Future studies will show that mobile biosensor-based movement detection technology will support identification of early PD stages and allow objective characterization of motor fluctuations in advanced stages of the disease. This will provide an important and supportive tool for patients, caregivers and therapists.
authors: Abteilung für Molekulare Neurologie und Spezialambulanz für Bewegungsstörungen in der Neurologischen Klinik, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054 Erlangen, Deutschland. jochen.klucken@uk-erlangen.de
authors: J
authors: J
authors: Klucken
authors: J
authors: J
authors: Barth
authors: K
authors: K
authors: Maertens
authors: B
authors: B
authors: Eskofier
authors: P
authors: P
authors: Kugler
authors: R
authors: R
authors: Steidl
authors: J
authors: J
authors: Hornegger
authors: J
authors: J
authors: Winkler
mesh_terms: D000054:Acceleration; D000368:Aged; D015374:Biosensing Techniques / Q000295:instrumentation*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D020233:Gait Disorders, Neurologic / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D012775:Shoes; D013813:Therapy, Computer-Assisted / Q000379:methods