title: [Management of anal canal carcinoma].
abstract: Although anal canal squamous cell carcinoma is rare, the general practitioner should consider this diagnosis in a patient with persistent lower abdominal symptoms. While classically observed in older women, an increased incidence is also seen in HIV-positive patients or patients with a history of human papillomavirus infection. Initial diagnosis and local work-up require assessment by a proctologist. Standard curative treatment combines radiotherapy with 5-FU- and MMC-based chemotherapy. Salvage surgery should be discussed in case of local relapse. The general practitioner, the proctologist and the radiation oncologist, all participate in post-treatment surveillance.
authors: Service d'oncologie, Département des spécialités de médecine, HUG, Genève. Nhu.N.TranThang@hcuge.ch
authors: N-N Tran
authors: NN
authors: Thang
authors: S
authors: S
authors: Cochet
authors: A-C
authors: AC
authors: George
authors: M
authors: M
authors: Betz
authors: A
authors: A
authors: Roth
mesh_terms: D001003:Anal Canal / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy* / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000628:therapy* / Q000821:virology; D003131:Combined Modality Therapy / Q000379:methods; D005472:Fluorouracil / Q000008:administration & dosage; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D015994:Incidence; D016685:Mitomycin / Q000008:administration & dosage; D012307:Risk Factors; D016879:Salvage Therapy / Q000379:methods; D017678:Sex Distribution; D013514:Surgical Procedures, Operative; D016896:Treatment Outcome
chemical_list: D016685:Mitomycin; D005472:Fluorouracil