title: Antipsychotics and venous thromboembolism risk: a meta-analysis.
abstract: BACKGROUND
  Antipsychotics have been inconclusively implicated in susceptibility to venous thromboembolism (VTE).
  
  
  OBJECTIVE
  The aim of this study was to investigate the association between antipsychotic drugs and VTE risk by a meta-analysis. PubMed and EmBASE databases were searched for publications through to 10 October 2010. Statistical analysis was performed using Revman 4.2 and Stata 10.0 software.
  
  
  RESULTS
  7 case-control studies involving 31 095 cases and 143 472 controls were analyzed. The results indicate that antipsychotic exposure confers a 139 % increased risk of VTE (odds ratio [OR] = 2.39, 95 % confidence interval [CI]:1.71–3.35). Pooled estimates by drug type showed that use of low-potency antipsychotics (OR = 2.91, 95 % CI 1.80–4.71) is the most important risk factor for VTE, followed by atypical (OR = 2.20, 95 % CI 1.22–3.96), conventional (OR = 1.72, 95 % CI 1.31–2.24) and high-potency drugs (OR = 1.58, 95 % CI 1.50–1.67).
  
  
  CONCLUSIONS
  This meta-analysis suggests that antipsychotics are a risk factor for VTE. Additional studies in large cohorts are required to validate our findings. Future analyses should study potential eff ect modifications by different doses and durations of antipsychotic exposure in different populations.
authors: Department of Respiratory Medicine, Sir Run Run Shaw Hospital , Zhejiang University School of Medicine, Hangzhou, People’s Republic of China.
authors: R
authors: R
authors: Zhang
authors: L
authors: L
authors: Dong
authors: F
authors: F
authors: Shao
authors: X
authors: X
authors: Tan
authors: K
authors: K
authors: Ying
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D006801:Humans; D016017:Odds Ratio; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000139:chemically induced*
chemical_list: D014150:Antipsychotic Agents