title: Common variants for atrial fibrillation: results from genome-wide association studies.
abstract: Atrial fibrillation (AF) affects more than 5 million people worldwide; however, none of the anti-arrhythmic drugs available now are entirely optimal in terms of efficacy and safety. A better understanding of the molecular mechanism of AF will facilitate the process of finding new strategies to prevent AF. As the non-familial AF is the major form of AF, identifying common variants for AF in these populations by genome-wide association studies will definitely accelerate this process. This review summarizes the recently identified common AF variants on 4q25, 16q22, and 1q21 and discusses their implications for the clinic.
authors: Department of Pediatrics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
authors: Xinyuan
authors: X
authors: Liu
authors: Fei
authors: F
authors: Wang
authors: Ashley C
authors: AC
authors: Knight
authors: Jiangmin
authors: J
authors: Zhao
authors: Junjie
authors: J
authors: Xiao
mesh_terms: D001281:Atrial Fibrillation / Q000235:genetics*; D005796:Genes / Q000502:physiology*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*