title: Risk factors for adverse events during collection of peripheral blood stem cells.
abstract: We retrospectively reviewed peripheral blood stem cell (PBSCs) collections following 528 mobilization cycles over a 10-year period. A total of 206 (13.1%) AEs occurred in association with the 1572 procedures. One hundred and ninety-one (12.15%) of the AEs were classified as clinical AEs and 15 (0.95%) were classified as apheresis instrument related AEs. The most common clinical AE was numbness of the lips, tongue, or extremities (161 procedures, 10.2%) related to the infusion of acid citrate dextrose-A (ACD). Multivariate analysis revealed high amounts of ACD/weight (odds ratio [OR]=1.11, p=0.009), high numbers of procedures (OR=1.33, p<0.001) and female gender (OR=2.83, p<0.001) as being significantly associated with clinical AEs. Female gender was shown to be the most important risk factor for clinical AEs. Females who have a significantly increased risk of AEs would benefit from prophylactic calcium before and/or during PBSC collection.
authors: Ege University Medical School, Department of Hematology, Izmir, Turkey. ayhan.donmez@ege.edu.tr
authors: Ayhan
authors: A
authors: Donmez
authors: Bahar
authors: B
authors: Arik
authors: Murat
authors: M
authors: Tombuloglu
authors: Seckin
authors: S
authors: Cagirgan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001781:Blood Component Removal / Q000009:adverse effects*; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects* / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult