title: Prevalence of celiac disease in parents of preterm or low birthweight newborns.
abstract: OBJECTIVE
  Celiac disease (CD) may present with atypical symptoms, including poor pregnancy outcomes, such as preterm and low birthweight (LBW) deliveries, thus we aimed to investigate the frequency of CD in mothers and fathers of preterm or LBW newborns.
  
  
  METHODS
  In this study, 316 parents of 164 preterm or LBW newborns and 246 parents of 123 healthy newborns were included. CD was screened using tissue transglutaminase immunoglobulin A. Endoscopic duodenal biopsy was provided in the seropositive cases.
  
  
  RESULTS
  Positive tissue transglutaminase immunoglobulin A was found in six (1.1%; 1/94) individuals (three mothers and three fathers); five were from the study group (1.6%; 1/63) and one was from the control group (0.4%; 1/246). CD prevalence in mothers, fathers and parents of preterm newborns was 1/57 (1.8%), 1/57 (1.8%) and 1/29 (3.5%), respectively. In the LBW group, seropositivity in fathers was 1/50 (2%) with no seropositive mothers. Biopsy-proven CD was found in 1/159 mothers (0.6%) and 1/79 fathers (1.3%). Mean birthweights of the newborns of seropositive mothers and fathers were 214 g (P < 0.05) and 320 g lower than those of seronegative ones, respectively. However, in logistic regression analysis it was found that seropositivity of mothers or fathers did not affect gestational age or birthweight of the newborns.
  
  
  CONCLUSIONS
  Because the prevalence of CD in parents of preterm or LBW newborns is not statistically higher than the healthy population, routine CD screening in that group cannot be recommended at the time being. For more definite conclusions further studies are needed.
authors: Department of Pediatrics, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors: Bilge
authors: B
authors: Ozgör
authors: Mukadder Ayşe
authors: MA
authors: Selimoğlu
authors: Ismail
authors: I
authors: Temel
authors: Yüksel
authors: Y
authors: Seçkin
authors: Ayşe
authors: A
authors: Kafkaslı
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000453:epidemiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology*; D008297:Male; D010290:Parents; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence