title: Two new withanolide lactones from flos daturae.
abstract: Chemical investigation of the 50% ethanol eluate fraction from a macroporous resin of flowers of Datura metel L. collected in the Jiangsu Province of China resulted in the isolation of two new withanolides, baimantuoluoline G (1) and baimantuoluoside H (2). Their structures were elucidated as (12β,6β,22R)-1,10-seco-6,12,27-trihydroxy-26-oxo-witha-3,5,24-trienolide-1-oic acid-ε-lactone (1) and (5β,6α,12β,22R)-5,6,12,27-tetra-hydroxy-1,26-dioxo-witha-2,24-dienolide-27-O-β-glucopyranoside (2) on the basis of extensive spectroscopic analysis (1D, 2D-NMR and HRESIMS) and chemical studies.
authors: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China. hxkuang@hotmail.com
authors: Hai-Xue
authors: HX
authors: Kuang
authors: Bing-You
authors: BY
authors: Yang
authors: Yong-Gang
authors: YG
authors: Xia
authors: Qiu-Hong
authors: QH
authors: Wang
mesh_terms: D058530:Datura metel / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D007783:Lactones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D054358:Withanolides / Q000737:chemistry*
chemical_list: D007783:Lactones; D054358:Withanolides