title: Effects of progesterone and testosterone on ICH-induced brain injury in rats.
abstract: Studies have shown that progesterone reduces brain injury, whereas testosterone increases lesion size after ischemic stroke. This study examined the effects of progesterone and testosterone on intracerebral hemorrhage (ICH)-induced brain injury. Male Sprague-Dawley rats received an injection of 100 μL autologous whole blood into the right basal ganglia. Progesterone (16 mg/kg), testosterone (15 mg/kg) or vehicle was given intraperitoneally 2 h after ICH. Behavioral tests were performed, and the rats were killed after 24 h for brain edema measurement. Perihematomal brain edema was reduced in progesterone-treated rats compared to vehicle-treated rats (p<0.05). Progesterone also improved functional outcome following ICH (p<0.05). Testosterone treatment did not affect perihematomal edema formation, but resulted in lower forelimb placing score (p<0.05). In conclusion, progesterone can reduce brain edema and improve functional outcome, whereas testosterone may have a deleterious effect after ICH in male rats.
authors: Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109-2200, USA.
authors: Zheng
authors: Z
authors: Chen
authors: Guohua
authors: G
authors: Xi
authors: Ying
authors: Y
authors: Mao
authors: Richard F
authors: RF
authors: Keep
authors: Ya
authors: Y
authors: Hua
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects; D001804:Blood Transfusion, Autologous / Q000009:adverse effects; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control; D001930:Brain Injuries / Q000188:drug therapy* / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000150:complications; D004195:Disease Models, Animal; D005552:Forelimb / Q000187:drug effects / Q000503:physiopathology; D042341:Gonadal Hormones / Q000627:therapeutic use*; D007477:Ions / Q000378:metabolism; D008297:Male; D011374:Progesterone / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000627:therapeutic use*
chemical_list: D042341:Gonadal Hormones; D007477:Ions; D013739:Testosterone; D011374:Progesterone