title: Rapid progression of hepatocellular carcinoma in a patient with autoimmune hepatitis.
abstract: We describe a case of a 69-year-old woman who developed rapidly progressive hepatocellular carcinoma (HCC) associated with autoimmune hepatitis (AIH) after a 7-year follow-up. Markers for viral hepatitis were negative. Serum tumor markers including alpha-fetoprotein and prothrombin induced by vitamin K absence II rose suddenly, and a large tumor was detected in spite of regular surveillance for HCC. Surgical treatment was performed. The resected liver specimen revealed well to moderately differentiated HCC. Ki67 staining showed rapid proliferation of the HCC. Although the incidence of HCC in patients with AIH has been unclarified, the possible complication by HCC must not be overlooked.
authors: The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan.
authors: Kayo
authors: K
authors: Yamamoto
authors: Masaaki
authors: M
authors: Hiura
authors: Akinari
authors: A
authors: Tabaru
authors: Yuichi
authors: Y
authors: Honma
authors: Ryoichi
authors: R
authors: Narita
authors: Shintaro
authors: S
authors: Abe
authors: Shohei
authors: S
authors: Shimajiri
authors: Kohji
authors: K
authors: Okamoto
authors: Koji
authors: K
authors: Yamaguchi
authors: Masaru
authors: M
authors: Harada
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D018450:Disease Progression; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D013997:Time Factors