title: Comparative genetics and genomics of nematodes: genome structure, development, and lifestyle.
abstract: Nematodes are found in virtually all habitats on earth. Many of them are parasites of plants and animals, including humans. The free-living nematode, Caenorhabditis elegans, is one of the genetically best-studied model organisms and was the first metazoan whose genome was fully sequenced. In recent years, the draft genome sequences of another six nematodes representing four of the five major clades of nematodes were published. Compared to mammalian genomes, all these genomes are very small. Nevertheless, they contain almost the same number of genes as the human genome. Nematodes are therefore a very attractive system for comparative genetic and genomic studies, with C. elegans as an excellent baseline. Here, we review the efforts that were made to extend genetic analysis to nematodes other than C. elegans, and we compare the seven available nematode genomes. One of the most striking findings is the unexpectedly high incidence of gene acquisition through horizontal gene transfer (HGT).
authors: Max Planck Institute for Developmental Biology, D-72076 T?bingen, Germany. ralf.sommer@tuebingen.mpg.de
authors: Ralf J
authors: RJ
authors: Sommer
authors: Adrian
authors: A
authors: Streit
mesh_terms: D000818:Animals; D005075:Biological Evolution; D005260:Female; D018507:Gene Expression Regulation, Developmental; D022761:Gene Transfer, Horizontal; D014644:Genetic Variation; D049751:Genome, Helminth; D008018:Life Cycle Stages; D008297:Male; D009348:Nematoda / Q000145:classification / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity; D010802:Phylogeny; D013045:Species Specificity