title: [Expression of tumor necrosis factor in placenta tissue of pregnant rats with chronic peridontitis].
abstract: OBJECTIVE
  To examine the expression of tumor necrosis factor in placenta of pregnant rats with chronic periodontitis.
  
  
  METHODS
  Twenty Wistar female rats were randomly divided into two groups, control (n = 8) and experimental group (n = 12). The periodontitis model was established in the experimental group. The females and males in the two groups got together four weeks later. Nineteen days after pregnancy all rats were executed and placenta collected. The delivery time and neonatal birth weight were recorded and the pathological changes of periodontal tissue observed. Tumor necrosis factor (TNF) expression was examined in placenta by real-time quantitative polymerase chain reaction analysis.
  
  
  RESULTS
  The animal model of chronic periodontitis was successfully established. Experimental group delivered 30 offspring and the control group 56 offspring. The average number of pups born alive per litter in experimental group (4.1 ± 2.2) was significantly lower than that in control group (9.2 ± 2.2), P < 0.05. The birth weight of pups in experimental group [(5.01 ± 0.43) g] was significantly lower than that in the control group [(5.79 ± 0.53) g], P < 0.05. The relative quantitative expression of TNF was (1.807 ± 0.265) in experimental group the and (1.003 ± 0.021) in the control group (P = 0.001).
  
  
  CONCLUSIONS
  Chronic periodontitis may be related to preterm low birth weight.
authors: Department of Periodontal and Mucosal Diease, The First Affiliated Hospital, Xinjiang Medical University, Urümqi 830054, China
authors: Jing
authors: J
authors: Liu
authors: Liang-jun
authors: LJ
authors: Zhong
authors: Fang-chuan
authors: FC
authors: Shi
authors: Lei
authors: L
authors: Zhang
authors: Qiong
authors: Q
authors: Zhang
authors: Da-lei
authors: DL
authors: Sun
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans; D000818:Animals; D000831:Animals, Newborn; D001724:Birth Weight; D055113:Chronic Periodontitis / Q000378:metabolism* / Q000382:microbiology; D004195:Disease Models, Animal; D005260:Female; D016967:Fusobacterium nucleatum; D010920:Placenta / Q000378:metabolism*; D016966:Porphyromonas gingivalis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000378:metabolism* / Q000382:microbiology; D018713:Prevotella intermedia; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha