title: Umbilical cord blood biomarkers of neurologic injury and the risk of cerebral palsy or infant death.
abstract: To evaluate the association between cerebral palsy (CP) or infant death and putative cord blood biomarkers of neurologic injury, we performed a nested case-control secondary analysis of a multicenter randomized trial of magnesium sulfate (MgSO(4)) versus placebo to prevent CP or death among offspring of women with anticipated delivery from 24 to 31 weeks' gestation. Cases were infants who died by 1 year (n=25) or developed CP (n=16), and were matched 1:2 to a control group (n=82) that survived without developing CP. Umbilical cord sera concentrations of S100B, neuron-specific enolase (NSE) and the total soluble form of the receptor for advanced glycation end-products (sRAGE) were measured by ELISA in duplicates. Maternal characteristics were similar between the 2 groups. Cases were born at a lower gestational age (GA) and had lower birth weight compared with controls. There were no differences in concentrations of the three biomarkers and the composite outcome of CP or infant death. However, S100B was higher (median 847.3 vs. 495.7 pg/ml; P=0.03) in infants who had CP and total sRAGE was lower (median 1259.3 vs. 1813.1 pg/ml; P=0.02) in those who died compared with the control group. When corrected for delivery GA and treatment group, both differences lost statistical significance. In conclusion, cord blood S100B level may be associated with CP, but this association was not significant after controlling for GA and MgSO(4) treatment.
authors: Department of Obstetrics and Gynecology at the University of Texas Medical Branch, Galveston, TX, USA. mmcostan@utmb.edu
authors: Maged M
authors: MM
authors: Costantine
authors: Steven J
authors: SJ
authors: Weiner
authors: Dwight J
authors: DJ
authors: Rouse
authors: Deborah G
authors: DG
authors: Hirtz
authors: Michael W
authors: MW
authors: Varner
authors: Catherine Y
authors: CY
authors: Spong
authors: Brian M
authors: BM
authors: Mercer
authors: Jay D
authors: JD
authors: Iams
authors: Ronald J
authors: RJ
authors: Wapner
authors: Yoram
authors: Y
authors: Sorokin
authors: John M
authors: JM
authors: Thorp
authors: Susan M
authors: SM
authors: Ramin
authors: Mary J
authors: MJ
authors: O'Sullivan
authors: Alan M
authors: AM
authors: Peaceman
authors: Hyagriv N
authors: HN
authors: Simhan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000097:blood* / Q000401:mortality* / Q000473:pathology*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D015337:Multicenter Studies as Topic; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D055815:Young Adult
chemical_list: D015415:Biomarkers