title: [Role of histone modifications in differentiation and effector function of CD8 T cells: update review including genome-wide analysis].
abstract: Evidence including genome-wide analyses have uncovered that epigenetic mechanisms regulate differentiation and effector functions in CD8 T cells. Gene expression profiles change when CD8 T cells differentiate from naïve T cells to memory T cells. It has been shown that this programmed differentiation is regulated by epigenetic mechanisms. Upon antigen stimulation, CD8 T cells activate and acquire effector functions to target cells. Effector molecule gene expressions are upregulated by epigenetic mechanisms in CD8 T cells. It is suggested that memory T cells respond more rapidly to antigens because chromatin structures of effector molecule genes are open and their gene transcriptions are poised for activation.
authors: Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
authors: Yasuto
authors: Y
authors: Araki
mesh_terms: D000818:Animals; D016827:CD8 Antigens; D002454:Cell Differentiation / Q000235:genetics*; D002843:Chromatin; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D055106:Genome-Wide Association Study; D006657:Histones / Q000378:metabolism*; D006801:Humans; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D014158:Transcription, Genetic; D015854:Up-Regulation / Q000235:genetics
chemical_list: D016827:CD8 Antigens; D002843:Chromatin; D006657:Histones