title: Hydroxyapatite granules used in the obliteration of mastoid cavities in rats.
abstract: Prospective experimental study in which we created a bony defect in the mastoids of rats and filled it up with hydroxyapatite to evaluate bone regeneration, to solve the problems of open cavities after mastoidectomies that frequently present with otorrhea, infection, granulation tissue and hearing loss.
  
  
  
  The aim was to evaluate bone regeneration in defects created in the mastoids of rats, using hydroxyapatite, to see how much of the cavity we could reduce.
  
  
  
  Twelve rats Wistar-Furth were used. A 0.5 x 0.5 cm bone defect was created in both temporal bones of the rats, and filled with 15 micrograms of hydroxyapatite. The left side was used as control. The animals were slaughtered 40 days afterwards and histology analyses were carried out.
  
  
  
  In the hydroxyapatite group, the new bone growth involved an area of 68.53% of the total; and in the control group it was only of 15.97%.
  
  
  
  It was observed a very good hydroxyapatite integration to the temporal bone in this experimental model. The microscopic results were superior with the use of hydroxyapatite when compared to the control group. It is a safe method and easy to apply to solve the problems of open cavities with chronic discharge and difficult to clean.
authors: Federal University of Paraná (UFPR).
authors: Rogério
authors: R
authors: Hamerschmidt
authors: Rafael Francisco dos
authors: RF
authors: Santos
authors: João Cândido
authors: JC
authors: Araújo
authors: Henrique Jorge
authors: HJ
authors: Stahlke
authors: Miguel Angelo
authors: MA
authors: Agulham
authors: Ana Tereza Ramos
authors: AT
authors: Moreira
authors: Marcos
authors: M
authors: Mocellin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration; D017886:Durapatite / Q000627:therapeutic use*; D008297:Male; D008416:Mastoid / Q000601:surgery*; D011446:Prospective Studies; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite