title: FCεRI gene promoter polymorphisms and total IgE levels in susceptibility to atopic dermatitis in Korea.
abstract: IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (FcεRI) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic diseases like atopic dermatitis (AD). We sought to determine FcεRI gene polymorphisms are associated with AD in Korean patients, and analyzed the relevance of FcεRI gene polymorphisms and serum IgE levels. We conducted a case-control association analysis (175 patients and 56 controls) of Korean subjects. Genotyping was performed using the TaqMan fluorogenic 5' nuclease assay, and serum levels of IgE were measured using a fluorescence enzyme immunoassay. We found that there were no significant relationships between FcεRI and AD, although there were trends towards an association between the 66T>C (rs2251746) polymorphism and total serum IgE levels in the Korean AD patients. In conclusion, while the 66T>C (rs2251746) of the FcεRIα polymorphism may be linked to AD and higher serum IgE levels, polymorphisms in the FcεRIβ gene did not confer susceptibility to AD in our patient sample.
authors: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors: Kui Young
authors: KY
authors: Park
authors: Mi Kyung
authors: MK
authors: Park
authors: Eun Joo
authors: EJ
authors: Kim
authors: Mi-Kyung
authors: MK
authors: Lee
authors: Seong Jun
authors: SJ
authors: Seo
mesh_terms: D000293:Adolescent; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D017455:Receptors, IgE / Q000235:genetics*; D056910:Republic of Korea
chemical_list: D017455:Receptors, IgE; D007073:Immunoglobulin E