title: [Myxoid mesenchymal tumors of uterus: endometrial stromal and smooth muscle tumors, myxoid variant].
abstract: Four myxoid variant of uterine mesenchymal tumors are reported. One was a low grade stromal sarcoma with infiltrative margins and the others were well circumscribed tumors corresponding to an endometrial stromal nodule and two leiomyomas. They were hypocellular neoplasms composed of stellated cells with an abundant Alcian Blue positive myxoid matrix. The myxoid nature of the neoplasms obscured their cellular nature and made the distinction between smooth muscle and endometrial stromal tumors difficult. Endometrial stromal tumors, showed very focal areas of small basophilic cells, characteristic of endometrial stroma. The diagnosis was based on the presence of a spiral arteriolar network, a CD10 positivity as well as the absence of h-caldesmon and desmin expression. The two myxoid leiomyomas showed more spindle cells and a desmin expression while h-caldesmon was negative and CD10 focally positive in both cases. Myxoid variant of endometrial stromal tumors does not necessarily exhibit the typical morphology of endometrial stroma. They may demonstrate morphological features of smooth muscle tumors in the uterus. Also, myxoid changes in uterin smooth muscle tumors may modify the classical immunoreactivity of smooth muscle markers in these tumors and make it difficult to distinguish between benign and malignant neoplasms. An immunohistochemical panel of antibodies including CD10, h-caldesmon and desmin may help in establishing the correct diagnosis.
authors: Service de pathologie Nord, hospices civils de Lyon, hôpital de la Croix Rousse, 103, Grande rue de la Croix Rousse, 69317 cedex 04 Lyon, France.
authors: Anne-Laure
authors: AL
authors: Chesnais
authors: Emmanuel
authors: E
authors: Watkin
authors: Daniel
authors: D
authors: Beurton
authors: Mojgan
authors: M
authors: Devouassoux-Shisheboran
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002148:Calmodulin-Binding Proteins / Q000032:analysis; D003893:Desmin / Q000032:analysis; D036821:Endometrial Stromal Tumors / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000737:chemistry / Q000145:classification / Q000473:pathology* / Q000601:surgery; D008637:Mesenchymoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology / Q000601:surgery; D009363:Neoplasm Proteins / Q000032:analysis; D015260:Neprilysin / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012189:Retrospective Studies; D013194:Staining and Labeling; D014594:Uterine Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D002148:Calmodulin-Binding Proteins; D003893:Desmin; D009363:Neoplasm Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D015260:Neprilysin