title: Association between serum nitric oxide metabolites and hypertension in a general population.
abstract: OBJECTIVE
  Endothelial dysfunction and impaired release of endothelial nitric oxide occurs in hypertension. The aim of this study was to determine the relation between nitric oxide metabolites (NOx) concentrations and blood pressure levels in a general population.
  
  
  METHODS
  In a cross-sectional study, NO(x)was measured in 2,968 adult subjects, randomly selected from a population-based study, using the Griess method. Subjects were classified into normal, prehypertension, stage 1 hypertension and stage two hypertension groups, according to the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure.
  
  
  RESULTS
  Serum NO(x)values were negatively correlated with systolic blood pressure ≥160 mm Hg in men (r=-0.523, P=0.002). Serum NOx was higher in men with stage 1 hypertension while those with stage 2 hypertension had significantly lower NO(x) levels. In men, medication increased serum NO(x) concentration in both stages of hypertension but in women, a significant increase was observed only in stage 1 hypertension.
  
  
  CONCLUSIONS
  Serum NO(x) concentrations decreased in untreated stage 2 hypertension and increased in stage 1 hypertension in men, findings that suggest NOx measurement might be helpful for assessing endothelial (dys) function in male hypertensive subjects.
authors: Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: A
authors: A
authors: Ghasemi
authors: S
authors: S
authors: Zahediasl
authors: L
authors: L
authors: Syedmoradi
authors: F
authors: F
authors: Azizi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D007492:Iran; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood*; D009573:Nitrites / Q000097:blood*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide