title: Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging.
abstract: We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm which, to our knowledge, is the smallest integrated OCT-US probe reported. Fast data acquisition and processing was implemented for real-time imaging. In vitro OCT and US images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated OCT-US probe to demonstrate its capability.
authors: Jiechen
authors: J
authors: Yin
authors: Xiang
authors: X
authors: Li
authors: Joe
authors: J
authors: Jing
authors: Jiawen
authors: J
authors: Li
authors: David
authors: D
authors: Mukai
authors: Sari
authors: S
authors: Mahon
authors: Ahmad
authors: A
authors: Edris
authors: Khiet
authors: K
authors: Hoang
authors: K Kirk
authors: KK
authors: Shung
authors: Matthew
authors: M
authors: Brenner
authors: Jagat
authors: J
authors: Narula
authors: Qifa
authors: Q
authors: Zhou
authors: Zhongping
authors: Z
authors: Chen
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000473:pathology; D004867:Equipment Design; D006801:Humans; D008297:Male; D008904:Miniaturization / Q000295:instrumentation*; D011817:Rabbits; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods; D018084:Ultrasonography, Interventional / Q000295:instrumentation* / Q000379:methods