title: FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells.
abstract: The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target of FOXP3 repression, but that FOXP3 also induces two miRs, miR-7 and miR-155, which specifically target the 3'-UTR of SATB1 to further regulate its expression. We conclude that FOXP3-regulated miRs form part of the mechanism by which FOXP3 prevents the transformation of the healthy breast epithelium to a cancerous phenotype. Approaches aimed at restoring FOXP3 function and the miRs it regulates could help provide new approaches to target breast cancer.
authors: Women's and Children's Health Research Institute, Molecular Immunology Laboratory, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA 5006, Australia.
authors: N
authors: N
authors: McInnes
authors: T J
authors: TJ
authors: Sadlon
authors: C Y
authors: CY
authors: Brown
authors: S
authors: S
authors: Pederson
authors: M
authors: M
authors: Beyer
authors: J L
authors: JL
authors: Schultze
authors: S
authors: S
authors: McColl
authors: G J
authors: GJ
authors: Goodall
authors: S C
authors: SC
authors: Barry
mesh_terms: D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D017930:Genes, Reporter; D006801:Humans; D049409:Luciferases, Firefly / Q000096:biosynthesis / Q000235:genetics; D036961:Matrix Attachment Region Binding Proteins / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D034622:RNA Interference
chemical_list: D051858:Forkhead Transcription Factors; D049409:Luciferases, Firefly; D036961:Matrix Attachment Region Binding Proteins; D035683:MicroRNAs; C418974:FOXP3 protein, human; C524942:MIRN155 microRNA, human; C549242:MIRN7-1 microRNA, human; C076189:SATB1 protein, human