title: [Research progress of tumor microenvironment and non-Hodgkin's lymphomas].
abstract: Non-Hodgkin's lymphoma cells including lymphoma stem cells reside in a specific microenvironment in which a series of nonmalignant bystander cells and cytokines play a crucial role in the genesis and development of non-Hodgkin's lymphomas. In addition, tumor microenvironment has important prognostic significance in Non-Hodgkin's lymphomas. Blocking the cross-talk between the tumor microenvironment and lymphoma cells may thus represent a promising new strategy for treating Non-Hodgkin's lymphomas. This review summarizes the current advance in studies of the tumor microenvironment and non-Hodgkin's lymphomas, including cells in tumor microenvironment, role of mesenchymal stem cells and stromal cells, auxiliary role of T cell subsets, macrcphage and dentritic cells, cytokines, immune surveillance and so on.
authors: Department of Hematology, Ruijin Hospital of Shanghai Jiaotong University Medical College, Shanghai 200025, China.
authors: Jing-Xia
authors: JX
authors: Chen
authors: Jun-Min
authors: JM
authors: Li
mesh_terms: D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines