title: In vitro antimicrobial effects of commercially available mouth-wetting agents.
abstract: Products have been developed to provide palliation for persons with dry mouth. In addition to mouth-wetting agents, some products incorporate antimicrobial constituents with the goal of improving oral microbial defenses. The aim of this in vitro study was to investigate the potential antimicrobial and antifungal effects of two commercially available saliva substitutes on Streptococcus mutans, Lactobacillus acidophilus, and Candida albicans by using the agar-well diffusion method. Antimicrobial activity as measured by the size of the inhibition zone growth for S. mutans and L. acidophilus was observed only with Biotene Dry Mouth Oral Rinse® and BioXtra® gel. The zone of inhibition of Biotene Dry Mouth Oral Rinse was larger than that of BioXtra gel (p= 0.00, p < 0.01). No anticandidal effect was seen with any of the test products. The pH of the preparations, the variations between the amount of active ingredients within the products, and the potential antimicrobial effects of inactive ingredients should be investigated to determine the factors that impacted microbial inhibition.
authors: Department of Oral Diagnosis and Radiology, School of Dentistry, Ege University, Izmir, Turkey.
authors: Pelin
authors: P
authors: Güneri
authors: Esin
authors: E
authors: Alpöz
authors: Joel B
authors: JB
authors: Epstein
authors: Hülya
authors: H
authors: Çankaya
authors: Mustafa
authors: M
authors: Ateş
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D058491:Bacterial Load; D002176:Candida albicans / Q000187:drug effects; D015169:Colony Count, Microbial; D045424:Complex Mixtures / Q000494:pharmacology; D004338:Drug Combinations; D005782:Gels; D005949:Glucose Oxidase / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007779:Lactobacillus acidophilus / Q000187:drug effects; D007784:Lactoperoxidase / Q000494:pharmacology; D008422:Materials Testing; D009067:Mouthwashes / Q000494:pharmacology; D009113:Muramidase / Q000494:pharmacology; D011108:Polymers; D011506:Proteins / Q000494:pharmacology; D012464:Saliva, Artificial / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; C460819:BioXtra; C111669:Biotene; D045424:Complex Mixtures; D004338:Drug Combinations; D005782:Gels; D009067:Mouthwashes; C114318:Oral Balance; D011108:Polymers; D011506:Proteins; D012464:Saliva, Artificial; D005949:Glucose Oxidase; D007784:Lactoperoxidase; D009113:Muramidase