title: In vivo fitness correlates with host-specific virulence of Infectious hematopoietic necrosis virus (IHNV) in sockeye salmon and rainbow trout.
abstract: The relationship between virulence and overall within-host fitness of the fish rhabdovirus Infectious hematopoietic necrosis virus (IHNV) was empirically investigated in vivo for two virus isolates belonging to different IHNV genogroups that exhibit opposing host-specific virulence. U group isolates are more virulent in sockeye salmon and M group isolates are more virulent in rainbow trout. In both single and mixed infections in the two fish hosts, the more virulent IHNV type exhibited higher prevalence and higher viral load than the less virulent type. Thus, a positive correlation was observed between higher in vivo fitness and higher host-specific virulence in sockeye salmon and rainbow trout. Comparisons of mean viral loads in single and mixed infections revealed no evidence for limitation due to competition effects between U and M viruses in either rainbow trout or sockeye salmon co-infections.
authors: Graduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA 98195, USA. mmdpena@u.washington.edu
authors: Ma Michelle D
authors: MM
authors: Peñaranda
authors: Andrew R
authors: AR
authors: Wargo
authors: Gael
authors: G
authors: Kurath
mesh_terms: D000818:Animals; D005393:Fish Diseases / Q000473:pathology / Q000821:virology*; D029142:Infectious hematopoietic necrosis virus / Q000254:growth & development / Q000472:pathogenicity*; D017686:Oncorhynchus mykiss / Q000821:virology*; D018353:Rhabdoviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D012474:Salmon / Q000821:virology*; D019562:Viral Load; D014774:Virulence