title: Tosylhydrazones: new uses for classic reagents in palladium-catalyzed cross-coupling and metal-free reactions.
abstract: Tosylhydrazones are useful synthetic intermediates that have been used in organic chemistry for almost 60 years. The recent discovery of a palladium-catalyzed cross-coupling reaction involving a tosylhydrazone coupling partner has triggered renewed interest in these reagents. This reaction shows nearly universal generality with regard to the hydrazone and can be employed for the preparation of polysubstituted alkenes. In the course of this research, novel metal-free C-C and C-O bond-forming reactions have been discovered. Since tosylhydrazones are readily prepared from carbonyl compounds, these transformations offer new synthetic opportunities for the unconventional modification of carbonyl compounds. This Minireview discusses all of these new reactions of a classic reagent.
authors: Departamento de Química Orgánica e Inorgánica e InstitutoUniversitario de Química Organometálica Enrique Moles, Universidad de Oviedo c/ Julián Clavería 8, Oviedo 33007, Spain. barluenga@uniovi.es
authors: José
authors: J
authors: Barluenga
authors: Carlos
authors: C
authors: Valdés