title: Regulated production of the pituitary hormone oxytocin from murine and human osteoblasts.
abstract: Oxytocin (OT) is a primitive neurohypophyseal hormone that plays a primary and indispensible role in mammalian lactation. We have shown recently that OT also regulates bone remodeling, mainly bone formation, with remarkable sensitivity. We now show that OT, apart from its neurohypophyseal origin, is produced in abundance by both human and murine osteoblasts. Production of osteoblast OT is under the control of estrogen, which acts by activating the MAP kinase Erk. This non-genomic mechanism of estrogen action is in stark contrast to its genomic control of OT receptor (OTR) expression. We surmise that there is a local feed-forward loop in bone marrow through which the OT so produced from osteoblasts in response to estrogen acts upon its receptor to exert a potent anabolic action.
authors: Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy.
authors: Graziana
authors: G
authors: Colaianni
authors: Adriana
authors: A
authors: Di Benedetto
authors: Ling-Ling
authors: LL
authors: Zhu
authors: Roberto
authors: R
authors: Tamma
authors: Jianhua
authors: J
authors: Li
authors: Giovanni
authors: G
authors: Greco
authors: Yuanzhen
authors: Y
authors: Peng
authors: Stefania
authors: S
authors: Dell'Endice
authors: Guangyu
authors: G
authors: Zhu
authors: Concetta
authors: C
authors: Cuscito
authors: Maria
authors: M
authors: Grano
authors: Silvia
authors: S
authors: Colucci
authors: Jameel
authors: J
authors: Iqbal
authors: Tony
authors: T
authors: Yuen
authors: Li
authors: L
authors: Sun
authors: Mone
authors: M
authors: Zaidi
authors: Alberta
authors: A
authors: Zallone
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism*; D010121:Oxytocin / Q000096:biosynthesis*
chemical_list: D004967:Estrogens; D010121:Oxytocin