title: Curative-intent stereotactic body radiation therapy for residual breast cancer liver metastasis after systemic chemotherapy.
abstract: Liver metastases from breast cancer are generally treated with systemic therapy such as chemotherapy or hormonotherapy. However, local treatment options such as resection, radiofrequency ablation (RFA), and radiotherapy can also be considered to treat oligometastases. We report the case of a 45-year-old female treated with stereotactic body radiotherapy (SBRT) after chemotherapy against a solitary liver metastasis from primary breast cancer. A liver metastasis with diameter of 35 mm developed 3.5 years after surgery for primary breast cancer in 2004. Fourteen courses of triweekly docetaxel treatments considerably decreased the metastatic lesion, but there still remained a tiny lesion radiographically. Chemotherapy was stopped because of the side-effects of docetaxel, and then SBRT was selected for additional treatment, aiming at complete cure of metastasis. X-ray irradiation (52.8 Gy/4 fractions) was applied to the remaining metastatic lesion, and magnetic resonance imaging (MRI) showed no evidence of residual tumor 4 months after irradiation. Neither regrowth nor recurrences have been found until now, 24 months after SBRT. SBRT for oligometastases of breast cancer may be one of the possible curative-intent options, being less invasive than surgical resection or RFA.
authors: Division of Breast and Endocrine Surgery, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka, 543-8922, Japan.
authors: Naofumi
authors: N
authors: Kagara
authors: Yoshiaki
authors: Y
authors: Nakano
authors: Ami
authors: A
authors: Watanabe
authors: Junichi
authors: J
authors: Inatome
authors: Hidetoshi
authors: H
authors: Nakamura
authors: Chiwan
authors: C
authors: Kim
authors: Katsuki
authors: K
authors: Danno
authors: Hirokazu
authors: H
authors: Taniguchi
authors: Toshiyuki
authors: T
authors: Kanoh
authors: Yutaka
authors: Y
authors: Kimura
authors: Tadashi
authors: T
authors: Ohnishi
authors: Takeshi
authors: T
authors: Tono
authors: Takushi
authors: T
authors: Monden
authors: Shingi
authors: S
authors: Imaoka
authors: Kazufumi
authors: K
authors: Kagawa
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000601:surgery; D016634:Radiosurgery; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D043823:Taxoids; D000077143:Docetaxel