title: Disposable microfluidic substrates: transitioning from the research laboratory into the clinic.
abstract: As more microfluidic applications emerge for clinical diagnostics, the choice of substrate and production method must be considered for eventual regulatory approval. In this review, we survey recent developments in disposable microfluidic substrates and their fabrication methods. We note regulatory approval for disposable microfluidic substrates will be more forthcoming if the substrates are developed with the United States Pharmacopeia's biocompatibility compliance guidelines in mind. We also review the recent trend in microfluidic devices constructed from a hybrid of substrates that takes advantage of each material's attributes.
authors: Department of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
authors: Jason S
authors: JS
authors: Kuo
authors: Daniel T
authors: DT
authors: Chiu
mesh_terms: D000818:Animals; D019411:Clinical Laboratory Techniques / Q000295:instrumentation*; D004209:Disposable Equipment / Q000706:statistics & numerical data; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D011108:Polymers / Q000737:chemistry
chemical_list: D011108:Polymers