title: Transforming growth factor-β1 polymorphisms and chronic obstructive pulmonary disease: a meta-analysis.
abstract: BACKGROUND
  Chronic obstructive pulmonary disease (COPD) is a complex polygenic disease in which gene- environment interactions play a critical role in disease onset and progression. Transforming growth factor-β 1 (TGF-β 1) is one of several candidate loci for the pathogenesis of COPD, and is highly polymorphic.
  
  
  OBJECTIVE
  To derive a more precise estimation of the relationship between the T869C and C-509T polymorphisms of the TGF-β 1 gene and COPD, a meta-analysis of 11 published case-control studies was performed.
  
  
  METHODS
  Ten studies with 1507 cases and 2542 controls for T869C polymorphism and six studies with 955 cases and 2136 controls for C-509T polymorphism were included. The pooled odds ratios were performed respectively for allele contrasts, additive genetic model, dominant genetic model and recessive genetic model. A subgroup analysis was also performed by ethnicity for T869C polymorphism.
  
  
  RESULTS
  With respect to T869C polymorphism, a significant association of TGF-β 1 gene polymorphism at 869T/C with COPD was observed in the overall analysis (C vs. T: OR 0.82, 95%CI 0.70-0.96, P = 0.01). In the subgroup analysis by ethnicity, significant risks were also found in the Caucasian population for C vs. T (OR 0.77, 95%CI 0.60-0.98, P = 0.03), but not in the Asian population (C vs. T: OR 0.88, 95%CI 0.76-1.03, P = 0.10). With respect to C-509T polymorphism, no significant association with COPD was demonstrated in the overall analysis (T vs. C: OR 0.84, 95%CI 0.68- 1.04, P = 0.11).
  
  
  CONCLUSIONS
  Potentially functional TGF-β 1 T869C polymorphism may play a low penetrance role in COPD susceptibility in an ethnicity-specific manner.
authors: School of Health Management, Anhui Medical University, Hefei, Anhui, China.
authors: L
authors: L
authors: Zhang
authors: W-W
authors: WW
authors: Chang
authors: H
authors: H
authors: Ding
authors: H
authors: H
authors: Su
authors: H-Y
authors: HY
authors: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D008957:Models, Genetic; D016017:Odds Ratio; D019683:Penetrance; D010641:Phenotype; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000208:ethnology / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1