title: Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements.
abstract: A total of 256 men were studied to evaluate whether serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) impacted semen quality or reproductive hormones. Blood and semen were collected and analyzed for perfluorochemicals and reproductive and thyroid hormones. Semen quality was assessed using standard clinical methods. Linear and logistic modeling was performed with semen profile measurements as outcomes and PFOS and PFOA in semen and plasma as explanatory variables. Adjusting for age, abstinence, and tobacco use, there was no indication that PFOA or PFOS was significantly associated with volume, sperm concentration, percent motility, swim-up motility and concentration, and directional motility (a function of motility and modal progression). Follicle-stimulating hormone was not associated with either PFOA or PFOS. Luteinizing hormone was positively correlated with plasma PFOA and PFOS, but not semen PFOS. Important methodological concerns included the lack of multiple hormonal measurements necessary to address circadian rhythms.
authors: RTI International, 3040 Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC 27709, United States. Electronic address: jraymer@rti.org.
authors: James H
authors: JH
authors: Raymer
authors: RTI International, 3040 Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
authors: Larry C
authors: LC
authors: Michael
authors: RTI International, 3040 Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
authors: William B
authors: WB
authors: Studabaker
authors: 3M Company, Occupational Medicine, Mail Stop 220-06-W-08, St. Paul, MN 55144, United States. Electronic address: gwolsen@mmm.com.
authors: Geary W
authors: GW
authors: Olsen
authors: RTI International, 3040 Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC 27709, United States.
authors: Carol S
authors: CS
authors: Sloan
authors: University of North Carolina at Chapel Hill, Epidemiology, Chapel Hill, NC 27599, United States. Electronic address: wilcosky@email.unc.edu.
authors: Timothy
authors: T
authors: Wilcosky
authors: Duke University Medical Center, Medical Director, Duke Fertility Center, 5704 Fayetteville Road Durham, NC 27713, United States. Electronic address: david.walmer@duke.edu.
authors: David K
authors: DK
authors: Walmer
mesh_terms: D017738:Alkanesulfonic Acids / Q000032:analysis* / Q000097:blood / Q000633:toxicity; D002210:Caprylates / Q000032:analysis* / Q000097:blood / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000032:analysis; D004785:Environmental Pollutants / Q000032:analysis* / Q000097:blood / Q000633:toxicity; D005466:Fluorocarbons / Q000032:analysis* / Q000097:blood / Q000633:toxicity; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D009657:North Carolina; D012661:Semen / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D053719:Tandem Mass Spectrometry; D013963:Thyroid Hormones / Q000378:metabolism
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D004785:Environmental Pollutants; D005466:Fluorocarbons; D013963:Thyroid Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid