title: Bioactive 11,20-epoxy-3,5(16)-diene briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
abstract: Seven new briarane diterpenoids, gemmacolides G-M (1-7), were isolated together with two known analogues, juncin O and junceellolide C, from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by detailed analysis of spectroscopic data and comparison with reported data. In an in vitro bioassay, these compounds exhibited different levels of growth inhibition activity against A549 and MG63 cells. In particular, compound 4 was more active than the positive control adriamycin against A549 cells. Compounds 4 and 7 also exhibited weak antimicrobial activity against the bacterium Bacillus megaterium and the fungus Septoria tritici, respectively.
authors: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, People's Republic of China.
authors: Cui
authors: C
authors: Li
authors: Ming-Ping
authors: MP
authors: La
authors: Ling
authors: L
authors: Li
authors: Xiu-Bao
authors: XB
authors: Li
authors: Hua
authors: H
authors: Tang
authors: Bao-Shu
authors: BS
authors: Liu
authors: Karsten
authors: K
authors: Krohn
authors: Peng
authors: P
authors: Sun
authors: Yang-Hua
authors: YH
authors: Yi
authors: Wen
authors: W
authors: Zhang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000187:drug effects; D001410:Bacillus megaterium / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009792:Oceans and Seas
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D004224:Diterpenes; C495052:juncin O; D004317:Doxorubicin