title: Metabolic surgery for type 2 diabetes.
abstract: Conventional bariatric operations, including Roux-en-Y gastric bypass (RYGB), laparoscopic adjustable gastric banding, and biliopancreatic diversion (BPD) appear to be a safe and effective treatment for many severely obese patients with type 2 diabetes mellitus (T2DM). These operations improve glucose homeostasis through a variety of mechanisms, however, not only due to reduced food intake and body weight. Research to elucidate the weight-independent antidiabetic mechanisms of gastrointestinal (GI) surgery and to clarify the molecular mechanisms responsible for the benefits of GI surgery on glucose homeostasis is a compelling research objective. We review the existing knowledge regarding the clinical outcomes and of the mechanisms of GI surgery to treat T2DM.
authors: Department of Surgery, Weill Cornell Medical Center, New York Presbyterian Hospital, New York, New York 10065, USA.
authors: Soo Min
authors: SM
authors: Ahn
authors: Alfons
authors: A
authors: Pomp
authors: Francesco
authors: F
authors: Rubino
mesh_terms: D050110:Bariatric Surgery; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D006801:Humans; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D016896:Treatment Outcome; D015431:Weight Loss