title: CardioDetect rapid test for the diagnosis of early acute myocardial infarction.
abstract: Two hundreds patients suspected of acute myocardial infarction presenting to the hospital with a median symptom onset of 2.3 h (IQR 1.7-4.0 h) were enrolled in this study. The diagnostic performances of CardioDetect®, a one-step immunotest for heart-type fatty acid-binding protein (H-FABP), and its combination with cardiac troponin I (cTnI) at admission and 2 h after admission, were compared with different cardiac markers. The H-FABP immunotest had better sensitivities (76.6% and 94.4%) than the other cardiac markers and better specificities (88.2% and 81.7%) than myoglobin at admission and 2 h after admission. Both sensitivity and negative predictive value increased to over 90.0% at 2 h after admission. The areas under the receiver operator characteristic curve for the combination of H-FABP with cTnI were the greatest at admission [0.834 (95% CI: 0.774-0.894)].
authors: Department of Emergency, Cardiovascular Institute & FuWai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China.
authors: Yan
authors: Y
authors: Liang
authors: Cangel P Y
authors: CP
authors: Chan
authors: Kwan-yee
authors: KY
authors: Cheung
authors: George W H
authors: GW
authors: Cautherley
authors: Jan F C
authors: JF
authors: Glatz
authors: Reinhard
authors: R
authors: Renneberg
authors: Jun
authors: J
authors: Zhu
mesh_terms: D000208:Acute Disease; D000368:Aged; D004632:Emergency Medical Services; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D009211:Myoglobin / Q000097:blood; D012680:Sensitivity and Specificity; D013997:Time Factors; D019210:Troponin I / Q000097:blood
chemical_list: C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D009211:Myoglobin; D019210:Troponin I