title: Interictal high frequency oscillations (HFOs) in patients with focal epilepsy and normal MRI.
abstract: OBJECTIVE
  We aim to analysis the relationship between HFOs-generating regions and the seizure onset zone (SOZ) in epileptic patients without a visible lesion on MRI.
  
  
  METHODS
  Intracerebral EEGs were recorded in 17 patients with intractable focal seizures and normal MRIs. The rates of interictal HFOs and spikes inside and outside the SOZ were analyzed as well as the specificity, sensitivity and accuracy of HFOs and spikes to determine the SOZ.
  
  
  RESULTS
  The mean rate of spikes, ripples and fast ripples (FR) was higher in the SOZ than in the non-SOZ channels. In regard to the identification of the SOZ the sensitivity was 91% for spikes, 91% for ripples and 66% for FR, the specificity was 30% for spikes, 42% for ripples and 80% for FR, and the accuracy was 44% for spikes, 54% for ripples and 76% for FR.
  
  
  CONCLUSIONS
  The rates of spikes and HFOs were higher inside than outside the SOZ. However, HFOs are also more specific and accurate than spikes to delineate the SOZ.
  
  
  CONCLUSIONS
  Analysis of interictal HFOs during 5-10 min of sleep recording is a good tool to localize the SOZ in patients with epilepsy and normal MRI, and could potentially reduce the duration of chronic intracerebral EEG recordings.
authors: Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
authors: Luciana
authors: L
authors: Andrade-Valença
authors: Francesco
authors: F
authors: Mari
authors: Julia
authors: J
authors: Jacobs
authors: Maeike
authors: M
authors: Zijlmans
authors: André
authors: A
authors: Olivier
authors: Jean
authors: J
authors: Gotman
authors: François
authors: F
authors: Dubeau
mesh_terms: D000293:Adolescent; D000328:Adult; D001683:Biological Clocks / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004828:Epilepsies, Partial / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted; D012890:Sleep / Q000502:physiology; D016896:Treatment Outcome; D055815:Young Adult