title: Results of early foetal echocardiography and cumulative detection rate of congenital heart disease.
abstract: OBJECTIVE
  The aim of this study is to evaluate the cumulative detection rate of foetal echocardiography during gestation and in the early neonatal period, with a special emphasis on early foetal echocardiography.
  
  
  METHODS
  We conducted a retrospective survey of all singleton pregnancies from 1993 to 2007, with complete sequential echocardiography from 11 plus 0 to 13 plus 6 weeks of gestation. It was mandatory to have at least one foetal echocardiography in the second or third trimester and one postnatally.
  
  
  RESULTS
  Our study included 3521 pregnancies, in which 77 cases were diagnosed with congenital heart disease. Of them, 66 were detected in the first trimester - 11 plus 0 to 11 plus 6 weeks: 22 cases; 12 plus 0 to 12 plus 6 weeks: 23 cases; 13 plus 0 to 13 plus 6 weeks: 21 cases - with an 85.7% detection rate of congenital heart disease in early foetal echocardiography. In the second trimester, seven cases were found, with a detection rate of 9.1%. The third trimester reported two cases, with a detection rate of 2.6%. Postnatally, two (2.6%) cases were detected. The overall in utero detection rate of congenital heart disease was 97.4%.
  
  
  CONCLUSIONS
  Foetal echocardiography performed at the time of anomaly screening in the first trimester results in high detection rates of congenital heart disease. Cardiac pathology may evolve, and further examinations at later stages of pregnancy could improve the detection rate of congenital heart disease.
authors: Department of Prenatal Medicine, University Hospital of Schleswig-Holstein, Luebeck, Germany. dhartge@gmail.com
authors: David R
authors: DR
authors: Hartge
authors: Jan
authors: J
authors: Weichert
authors: Martin
authors: M
authors: Krapp
authors: Ute
authors: U
authors: Germer
authors: Ulrich
authors: U
authors: Gembruch
authors: Roland
authors: R
authors: Axt-Fliedner
mesh_terms: D005260:Female; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal / Q000706:statistics & numerical data*