title: IL-17 in spondyloarthritis: is the T-party over?
abstract: The past decade has witnessed significant progress in revealing an important role for IL-17 in the pathogenesis of several immune-mediated inflammatory diseases. Recent studies have provided new insights into the cellular source of IL-17, originally identified as the signature cytokine of a distinct CD4(+) T-cell subset known as Th17. Accumulating evidence suggests that the majority of the IL-17 released in inflammatory arthritis is produced by innate immune cells rather than T cells. Understanding molecular mechanisms behind these early innate immune responses will be the key to designing rational therapies targeting these important inflammatory pathways.
authors: Nataliya
authors: N
authors: Yeremenko
authors: Dominique
authors: D
authors: Baeten
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D013167:Spondylitis, Ankylosing / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D021801:Zygapophyseal Joint / Q000276:immunology*
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17