title: Assessment of the epidemiology and burden of measles in Southern Mozambique.
abstract: Measles has been a major killer among vaccine-preventable diseases in children < 5 years of age in developing countries. Despite progress in global efforts to reduce mortality, measles remains a public health problem. Hospital-based measles surveillance was conducted in Manhica, Mozambique (July 2001-September 2004). Suspected cases and community-based controls were enrolled, and blood was collected for immunoglobulin M (IgM) confirmation. Two hundred fifty-three suspected cases and 477 controls were enrolled, with 85% (216 of 253) cases reported during a measles outbreak. Measles-IgM confirmation was 30% among suspected cases and 5% in controls. Fifty-eight percent (14 of 24) of laboratory-confirmed cases had records indicating previous measles vaccination. Mortality was 3% (8 of 246) among cases and 1% among controls (6 of 426). Forty-five percent (33 of 74) of cases were < 24 months of age and 22% occurred in infants < 9 months of age and were associated with a high case-fatality rate (25%). Our data suggest that improved diagnostics, new tools to protect infants < 9 months of age, and a supplemental dose of measles vaccine could assist measles control.
authors: Centro de Investigação em Saúde da Manhiça (CISM), Maputo, Mozambique; Instituto Nacional de Saúde, Ministério de Saúde, Maputo, Mozambique. imandomando2004@yahoo.com.br
authors: Inácio
authors: I
authors: Mandomando
authors: Denise
authors: D
authors: Naniche
authors: Marcela F
authors: MF
authors: Pasetti
authors: Lilian
authors: L
authors: Cuberos
authors: Sergi
authors: S
authors: Sanz
authors: Xavier
authors: X
authors: Vallès
authors: Betuel
authors: B
authors: Sigauque
authors: Eusébio
authors: E
authors: Macete
authors: Delino
authors: D
authors: Nhalungo
authors: Karen L
authors: KL
authors: Kotloff
authors: Myron M
authors: MM
authors: Levine
authors: Pedro L
authors: PL
authors: Alonso
mesh_terms: D016022:Case-Control Studies; D004196:Disease Outbreaks; D006801:Humans; D008457:Measles / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage; D009073:Mozambique / Q000453:epidemiology; D011159:Population Surveillance
chemical_list: D008458:Measles Vaccine