title: Poorer outcome in Polynesian patients with prostate cancer treated with definitive conformational radiation therapy.
abstract: OBJECTIVE
  To compare freedom from biochemical failure (FFBF) of French Polynesian (FP) and Native European (NE) prostate cancer patients after definitive conformal radiotherapy (RT).
  
  
  METHODS
  Data were reviewed from medical records of 152 consecutive patients (46 FP and 106 NE) with clinically localised prostate cancer treated with definitive RT. Neoadjuvant androgen deprivation therapy (ADT) was used in 22% of cases. Definition for biochemical failure was a rise by 2 ng/mL or more above the nadir prostate-specific antigen (PSA) level. The median follow-up was 34 months.
  
  
  RESULTS
  In comparison to NE patients, FP patients were younger (p=0.002) with a higher low-risk proportion (p=0.06). Probability of 5-year FFBF was 77% in the NE cohort and 58.0% in the FP cohort (p=0.017). Univariate analysis showed that FP ethnicity was associated with worse prognosis in high-risk tumours (p=0.004). Cox multivariate analysis showed that factors associated with FFBF were risk category (p<0.017), and FP origin (p=0.03), independently of ADT and radiation dose.
  
  
  CONCLUSIONS
  FP ethnicity was an independent prognostic factor for biochemical relapse after definitive conformal RT for prostate cancer.
authors: Department of Radiation Oncology, Pitie-Salpetriere University Hospital, Paris, France.
authors: Antonin
authors: A
authors: Levy
authors: Cyrus
authors: C
authors: Chargari
authors: Gonzague
authors: G
authors: Desrez
authors: Stéphane
authors: S
authors: Leroux
authors: Mary Jane
authors: MJ
authors: Sneyd
authors: Pierre
authors: P
authors: Mozer
authors: Eva
authors: E
authors: Comperat
authors: Loïc
authors: L
authors: Feuvret
authors: Philippe
authors: P
authors: Lang
authors: Stéphane
authors: S
authors: Lopez
authors: Avi
authors: A
authors: Assouline
authors: Charles
authors: C
authors: Hemery
authors: Jean Jacques
authors: JJ
authors: Mazeron
authors: Jean Marc
authors: JM
authors: Simon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D011114:Polynesia; D016016:Proportional Hazards Models; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen