title: Targeted delivery and controllable release of nanoparticles using a defect-decorated optical nanofiber.
abstract: Targeted drug delivery and controllable release are particularly beneficial in medical therapy. This work provides a demonstration of nanoparticles targeted delivery and controllable release using a defect-decorated optical nanofiber (NF). By using the NF, polystyrene particles (PSs) (713-nm diameter) suspended in water were successfully trapped, then delivered along the NF at an average velocity of 4.8 µm/s with the assistance of a laser beam of 980-nm wavelength at an optical power of 39 mW, and finally, assembled at the defect. Subsequently, by turning off the optical power, 90% of the assembled PSs can be released in 30 s. This method would be useful in targeted drug delivery and controllable release, and provide potential applications in targeted therapy.
authors: State Key Laboratory of Optoelectronic Materials and Technologies, School of Physics and Engineering, Sun Yat-Sen University, Guangzhou, China.
authors: Hongbao
authors: H
authors: Xin
authors: Baojun
authors: B
authors: Li
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry*; D005336:Fiber Optic Technology / Q000379:methods*; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011137:Polystyrenes / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D053769:Nanocapsules; D011137:Polystyrenes