title: [Dioxins and food safety].
abstract: Among numerous potential chemical food contaminants, polychlorinated dibenzo-p-dioxins, dibenzofurans and dioxin-like polychlorinated biphenyls, collectively referred as dioxins, are commonly considered as bearing substantial risk for human health due to their toxicological properties, persistency and ability to bioaccumulate in food chains. The results of epidemiological studies suggest that environmental exposure to these compounds may affect multiple physiological processes in humans, mainly by the mechanism of endocrine disruption. Adverse health effects linked to the long-term exposure to dioxins include the increase of cancer risk, reproductive and developmental impairment as well as effects on immune functions. Exposure through food (mainly of animal origin) is the major source of dioxin exposure for humans, estimated to account for about 95% of the total intake for non-occupationally exposed persons. Recent studies showed that a consistent part of the European population has an intake exceeding internationally agreed "safe" doses as the Tolerable Daily or Weekly Intake (TDI, TWI). It is worthy to note that percentage of persons with estimated dioxin intake above tolerable limits is much higher among children than in adults. Since the "Belgian dioxin crisis" that occurred in 1999, the estimation of human exposure to these compounds and related consumer risk assessment has been recognized in the European Union as one of the priority activities in the field of food safety. Among activities undertaken by the European Commission during implementation of the Community Strategy for dioxins, furans and polychlorinated biphenyls the maximum and action levels have been established with random monitoring by Member States. The legislation on the requirements for sampling and methods of analysis used in the official control laboratories has been set up as well. Member States are obliged to measure background levels of dioxins and dioxin-like PCBs in defined food categories for the EU monitoring program on a yearly basis and to forward the results to the European Commission (since 2008 to the European Food Safety Authority). The monitoring results, covering samples collected from 1999 to 2008, evaluated and reported recently by EFSA, became the basis for updating maximum levels of dioxins and dl-PCBs as set up in Commission Regulation (EC) 1881/2006. The legislation will also be changed by replacing the current toxicity equivalency factors (TEFs) system from 1998 (WHO,1998-TEFs) by a new TEFs proposed by the WHO in 2005 (WHO 2005-TEFs). It is expected that new limits for dioxins and dl-PCBs in food will come into force not later than in the beginning of 2012.
authors: Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego - Pańistwowy Zakład Higieny, Warszawa. pstrucinski@pzh.gov.pl
authors: Paweł
authors: P
authors: Struciński
authors: Jadwiga
authors: J
authors: Piskorska-Pliszczyńska
authors: Katarzyna
authors: K
authors: Góralczyk
authors: Małgorzata
authors: M
authors: Warenik-Bany
authors: Sebastian
authors: S
authors: Maszewski
authors: Katarzyna
authors: K
authors: Czaja
authors: Jan K
authors: JK
authors: Ludwicki
mesh_terms: D004147:Dioxins / Q000633:toxicity*; D004781:Environmental Exposure / Q000517:prevention & control*; D004784:Environmental Monitoring / Q000331:legislation & jurisprudence*; D005062:European Union; D020387:Food Chain; D005506:Food Contamination / Q000331:legislation & jurisprudence* / Q000517:prevention & control*; D059022:Food Safety / Q000379:methods; D006801:Humans; D018570:Risk Assessment
chemical_list: D004147:Dioxins