title: Upfront therapy of acute myeloid leukemia.
abstract: Acute myeloid leukemia is a clinically and biologically heterogeneous disease. Standard induction chemotherapy, consisting of cytarabine and an anthracycline, has not changed substantially over several decades, and outcomes remain suboptimal, particularly in older patients. Many genetic and molecular changes have been identified that guide selection of post-remission therapy and for which targeted therapies are beginning to be developed and tested. These research efforts are resulting in gradual improvement in outcomes. We will review here recent advances in induction chemotherapy, including anthracycline dose intensification in younger patients, treatment selection and use of novel agents in upfront therapy for older patients, and risk-adapted post-remission therapy.
authors: Department of Internal Medicine, University of Maryland Medical Center, Baltimore, MD, 21201, USA. jcanzoniero@umaryland.edu
authors: Jenna Vanliere
authors: JV
authors: Canzoniero
authors: Bhavana
authors: B
authors: Bhatnagar
authors: Maria R
authors: MR
authors: Baer
authors: Ivana
authors: I
authors: Gojo
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D018943:Anthracyclines / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D060828:Induction Chemotherapy / Q000379:methods*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000628:therapy; D008297:Male; D008875:Middle Aged
chemical_list: D018943:Anthracyclines