title: Thermoresponsive polypeptides from pegylated poly-L-glutamates.
abstract: The synthesis and characterization of new thermoresponsive pegylated poly-L-glutamate (poly-L-EG(x)Glu) are described. The obtained polypeptides display low critical solution temperature (LCST) behaviors in water, and the LCST can be tuned via copolymerization of different amino acid monomers at varied molar ratio. This is the first example of thermoresponsive polypeptide made from ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs). Circular dichroism characterizations reveal that the secondary structure of poly-L-EG(x)Glu depended on the chain length of the side chain.
authors: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Science Beijing, 100190 China.
authors: Chongyi
authors: C
authors: Chen
authors: Zhaohui
authors: Z
authors: Wang
authors: Zhibo
authors: Z
authors: Li
mesh_terms: D002942:Circular Dichroism; D006358:Hot Temperature; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D010455:Peptides; D011099:Polyglutamic Acid; D011092:Polyethylene Glycols