title: Effect of rice-expressed amyloid β in the Tg2576 Alzheimer's disease transgenic mouse model.
abstract: One of the main hallmarks of Alzheimer's disease (AD) is senile plaques composed of amyloid β (Aβ). We developed a new edible vaccine: rice expressing GFP-Aβ42. In a previous report, we described the production of anti-Aβ antibodies in B6 mice fed Aβ rice mixed with cholera toxin B subunit (CTB). In this report, we investigated whether Aβ rice had therapeutic effects in the Tg2576 AD model mice. The anti-Aβ antibody titer was increased and levels of intracerebral Aβ (soluble and insoluble) and serum Aβ decreased. Because the value of IgG1/IgG2a in the Aβ feeding group was >1, immunization via Aβ rice may induce a non-inflammatory Th2 reaction. We also found that the Aβ vaccine improved memory, as assessed in a Y-maze test. The number of arm entries in the Y-maze test was lower in the Aβ feeding group than in the control group. These results suggest that the new edible vaccine Aβ rice may have therapeutic effects in AD.
authors: Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.
authors: Jun
authors: J
authors: Nojima
authors: Azusa
authors: A
authors: Maeda
authors: Sho
authors: S
authors: Aoki
authors: Satoshi
authors: S
authors: Suo
authors: Dai
authors: D
authors: Yanagihara
authors: Yuichiro
authors: Y
authors: Watanabe
authors: Taiji
authors: T
authors: Yoshida
authors: Shoichi
authors: S
authors: Ishiura
mesh_terms: D000284:Administration, Oral; D000544:Alzheimer Disease / Q000276:immunology / Q000517:prevention & control / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008822:Mice, Transgenic; D012275:Oryza / Q000235:genetics / Q000276:immunology; D030821:Plants, Genetically Modified / Q000276:immunology*; D058225:Plaque, Amyloid / Q000276:immunology*; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use; D022462:Vaccines, Edible / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D016229:Amyloid beta-Peptides; D014612:Vaccines; D022462:Vaccines, Edible