title: Solid-state NMR sequential assignments of α-synuclein.
abstract: Parkinson's disease is amongst the most frequent and most devastating neurodegenerative diseases. It is tightly associated with the assembly of proteins into high-molecular weight protein species, which propagate between neurons in the central nervous system. The principal protein involved in this process is α-synuclein which is a structural component of the Lewy bodies observed in diseased brain. We here present the solid-state NMR sequential assignments of a new fibrillar form of this protein, the first one with a well-ordered and rigid N-terminal part.
authors: Physical Chemistry, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.
authors: Julia
authors: J
authors: Gath
authors: Birgit
authors: B
authors: Habenstein
authors: Luc
authors: L
authors: Bousset
authors: Ronald
authors: R
authors: Melki
authors: Beat H
authors: BH
authors: Meier
authors: Anja
authors: A
authors: Böckmann
mesh_terms: D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D051844:alpha-Synuclein / Q000737:chemistry*
chemical_list: D051844:alpha-Synuclein