title: Lack of association between CD58 genetic variations and aspirin-exacerbated respiratory disease in a Korean population.
abstract: BACKGROUND
  Exacerbation of asthma symptoms due to aspirin ingestion may lead to life-threatening lung failure. The adhesion molecule CD58 gene may play a crucial role in aspirin-exacerbated respiratory disease (AERD) pathogenesis by mediating the biological functions of asthma-inducing mechanisms including T helper cells, proinflammatory cytokines, and natural killer T cells.
  
  
  OBJECTIVE
  This study aimed to investigate the association of CD58 variations with aspirin-induced bronchospasm in Korean asthma patients.
  
  
  METHODS
  Seven single-nucleotide polymorphisms were selected for genotyping based on previously reported polymorphisms in the International HapMap database. Genotyping was carried out using TaqMan assay and 2 major haplotypes were obtained in 163 AERD cases and 429 aspirin-tolerant asthma controls. Frequency distributions of CD58 variations were analyzed using logistic and regression models.
  
  
  RESULTS
  Results showed that none of the analyzed CD58 single-nucleotide polymorphisms and haplotypes was significantly associated with AERD development and fall rate of FEV(1) by aspirin provocation, an important diagnostic marker of aspirin hypersensitivity.
  
  
  CONCLUSIONS
  This preliminary study suggests that CD58 does not affect AERD susceptibility in a Korean population, and may provide a new direction for future disease etiology.
authors: Department of Life Science, Sogang University, Seoul, Republic of Korea.
authors: Charisse Flerida A
authors: CF
authors: Pasaje
authors: Joon Seol
authors: JS
authors: Bae
authors: Byung-Lae
authors: BL
authors: Park
authors: Hyun Sub
authors: HS
authors: Cheong
authors: An-Soo
authors: AS
authors: Jang
authors: Soo-Taek
authors: ST
authors: Uh
authors: Mi-Kyeong
authors: MK
authors: Kim
authors: Jeong-Hyun
authors: JH
authors: Kim
authors: Tae-Joon
authors: TJ
authors: Park
authors: Jin-Sol
authors: JS
authors: Lee
authors: Yongha
authors: Y
authors: Kim
authors: Choon-Sik
authors: CS
authors: Park
authors: Hyoung Doo
authors: HD
authors: Shin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001241:Aspirin / Q000494:pharmacology; D055963:Asthma, Aspirin-Induced / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D015992:Body Mass Index; D001985:Bronchial Provocation Tests; D018968:CD58 Antigens / Q000235:genetics*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D056910:Republic of Korea; D012907:Smoking / Q000453:epidemiology; D055815:Young Adult
chemical_list: D018968:CD58 Antigens; D016210:Methacholine Chloride; D001241:Aspirin