title: Tumor necrosis factor-alpha promotes tumor growth by inducing vascular endothelial growth factor.
abstract: Tumor necrosis factor (TNF)-α has been proved as an adjuvant therapy for tumor by FDA. However, the effect of chronic TNF-α expression for tumor is still controversial. In this study, we investigated the effect of low-dose TNF-α on tumor growth. We confirmed that low-dose TNF-α promoted angiogenesis of tumor in vivo, vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1α, the transcription factor of VEGF, were both upregulated. Our results suggested that low-dose TNF-α was a powerful activator of angiogenesis in tumor and HIF-1α-VEGF pathway seemed to be the most important molecular mechanism.
authors: Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
authors: Yingying
authors: Y
authors: Jing
authors: Nannan
authors: N
authors: Ma
authors: Tingting
authors: T
authors: Fan
authors: Chenyang
authors: C
authors: Wang
authors: Xinxin
authors: X
authors: Bu
authors: Guocheng
authors: G
authors: Jiang
authors: Rong
authors: R
authors: Li
authors: Lu
authors: L
authors: Gao
authors: Ding
authors: D
authors: Li
authors: Mengchao
authors: M
authors: Wu
authors: Lixin
authors: L
authors: Wei
mesh_terms: D000482:Allantois / Q000098:blood supply; D000818:Animals; D018952:Antigens, CD34 / Q000096:biosynthesis; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002642:Chick Embryo; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology; D008546:Melanoma, Experimental / Q000098:blood supply / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000209:etiology; D018919:Neovascularization, Physiologic; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
chemical_list: D018952:Antigens, CD34; C497443:Hif1a protein, mouse; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A