title: Light-induced release of DNA from gold nanoparticles: nanoshells and nanorods.
abstract: Plasmon-resonant nanoparticle complexes show highly promising potential for light-triggered, remote-controlled delivery of oligonucleotides on demand, for research and therapeutic purposes. Here we investigate the light-triggered release of DNA from two types of nanoparticle substrates: Au nanoshells and Au nanorods. Both light-triggered and thermally induced release are distinctly observable from nanoshell-based complexes, with light-triggered release occurring at an ambient solution temperature well below the DNA melting temperature. Surprisingly, no analogous measurable release was observable from nanorod-based complexes below the DNA melting temperature. These results suggest that a nonthermal mechanism may play a role in plasmon resonant, light-triggered DNA release.
authors: Department of Chemistry, Rice University, Houston, Texas 77005, USA.
authors: Ryan
authors: R
authors: Huschka
authors: Jorge
authors: J
authors: Zuloaga
authors: Mark W
authors: MW
authors: Knight
authors: Lisa V
authors: LV
authors: Brown
authors: Peter
authors: P
authors: Nordlander
authors: Naomi J
authors: NJ
authors: Halas
mesh_terms: D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D010316:Particle Size; D020349:Surface Plasmon Resonance; D013499:Surface Properties; D044366:Transition Temperature
chemical_list: D006046:Gold; D004247:DNA