title: A randomized, placebo-controlled, double-blind study to evaluate the efficacy of a citrus bioflavanoid blend in the treatment of senile purpura.
abstract: BACKGROUND
  Senile purpura is a common, chronic skin condition affecting more than 10 percent of individuals over the age of 50. Despite being a benign condition, the continual development of purpura lesions in afflicted patients is frequently a source of significant visual and social concern. To date, there are no known effective treatments for this condition.
  
  
  OBJECTIVE
  To evaluate the efficacy of a novel nutraceutical citrus bioflavonoid blend in improving the skin's appearance in patients with senile purpura.
  
  
  METHODS
  A six-week, randomized, multicenter, placebo-controlled, double-blind study was conducted to determine whether a uniquely formulated, oral citrus bioflavonoid supplement could treat active lesions of senile purpura while preventing new lesions from arising. Seventy patients with senile purpura were enrolled and 67 completed the study. Subjects were randomized into two groups receiving either a citrus bioflavonoid blend or placebo medication, which was taken orally twice daily for six weeks. Clinical evaluations were performed by blinded investigators at two locations.
  
  
  RESULTS
  A statistically significant reduction in the number of new purpura lesions in the skin area undergoing clinical study was documented. At the end of six weeks, the citrus bioflavonoid blend treated group showed a 50 percent reduction in purpura lesions from baseline. Patient self-assessment of the effectiveness of the medication echoed the results of an investigator global assessment with a statistically significant improvement in the skin's appearance noted by the patients receiving the active medication. No adverse effects were noted by either the patients or investigators.
  
  
  CONCLUSIONS
  This new treatment appears to both safely and effectively diminish skin bruising in patients with senile purpura.
authors: Dermatology Associates, PA, of the Palm Beaches, Boynton Beach, FL 33437, USA.
authors: Joshua M
authors: JM
authors: Berlin
authors: David P
authors: DP
authors: Eisenberg
authors: Mindy B
authors: MB
authors: Berlin
authors: Robert A
authors: RA
authors: Sarro
authors: Douglas R
authors: DR
authors: Leeman
authors: Howard
authors: H
authors: Fein
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D002957:Citrus; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D011693:Purpura / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010936:Plant Extracts