title: Highly active organocatalysts for asymmetric anti-Mannich reactions.
abstract: Lighten the load! A family of enantiopure 4-oxy-substituted 3-aminopyrrolidines arising from the enantioselective ring-opening of meso-3-pyrroline oxide have been developed as catalysts for the asymmetric, anti-selective Mannich reaction (see scheme; PMP=p-methoxyphenyl; PG=protecting group). Very high catalytic activity (down to 0.01 mol % loading) and stereoselectivity have been recorded.
authors: Institute of Chemical Research of Catalonia (ICIQ), Tarragona, Spain.
authors: Rafael
authors: R
authors: Martín-Rapún
authors: Xinyuan
authors: X
authors: Fan
authors: Sonia
authors: S
authors: Sayalero
authors: Mahboubeh
authors: M
authors: Bahramnejad
authors: Félix
authors: F
authors: Cuevas
authors: Miquel A
authors: MA
authors: Pericàs
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000588:Amines; D007097:Imines; D007659:Ketones; D011759:Pyrrolidines