title: Complete response to chemoradiotherapy in a patient with synchronous double gastric and esophageal cancer.
abstract: A 77-year-old man with early synchronous double primary gastric and esophageal cancer showed complete response (CR) to chemoradiotherapy (CRT) with fluorouracil (5-FU) and cis-diamminedichloroplatinum (CDDP) and 60 Gy total dose of radiation. Gastrointestinal endoscopy had revealed type IIc squamous cell carcinoma in the lower oesophagus and type IIc adenocarcinoma in the mid-stomach region. Synchronous double primary early-stage esophageal and gastric cancer was diagnosed. The patient's age and chronic obstructive pulmonary disease (COPD) contraindicated radical esophageal surgery. Therefore, we decided to first administer CRT with 5-FU and CDDP for the esophageal cancer, and subsequently perform partial gastrectomy for the gastric cancer. After the CRT, neither of the tumors recurred. CR to CRT for the esophageal cancer and CR to chemotherapy for the gastric cancer were achieved.
  
  
  CONCLUSIONS
  CRT with 5-FU and CDDP can produce CR in cases of early esophageal and gastric cancer.
authors: Department of Digestive Surgery, Nihon University School of Medicine, 30-1 Ohyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan.
authors: Naoki
authors: N
authors: Yoshida
authors: Mitsugu
authors: M
authors: Kochi
authors: Masashi
authors: M
authors: Fujii
authors: Noriaki
authors: N
authors: Kanamori
authors: Teruo
authors: T
authors: Kaiga
authors: Yoshiaki
authors: Y
authors: Mihara
authors: Tomoya
authors: T
authors: Funada
authors: Hidenori
authors: H
authors: Tamegai
authors: Megumu
authors: M
authors: Watanabe
authors: Tadatoshi
authors: T
authors: Takayama
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy* / Q000532:radiotherapy*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery
chemical_list: D002945:Cisplatin; D005472:Fluorouracil