title: Analysis of the genome and proteome composition of Bdellovibrio bacteriovorus: indication for recent prey-derived horizontal gene transfer.
abstract: The genome/proteome composition of Bdellovibrio bacteriovorus, the predatory microorganism that preys on other Gram-negative bacteria, has been analyzed. The study elucidates that translational selection plays a major role in genome compositional variation with higher intensity compared to other deltaproteobacteria. Other sources of variations having relatively minor contributions are local GC-bias, horizontal gene transfer and strand-specific mutational bias. The study identifies a group of AT-rich genes with distinct codon composition that is presumably acquired by Bdellovibrio recently from Gram-negative prey-bacteria other than deltaproteobacteria. The proteome composition of this species is influenced by various physico-chemical factors, viz, alcoholicity, residue-charge, aromaticity and hydropathy. Cell-wall-surface-anchor-family (CSAPs) and transporter proteins with distinct amino acid composition and specific secondary-structure also contribute notably to proteome compositional variation. CSAPs, which are low molecular-weight, outer-membrane proteins with highly disordered secondary-structure, have preference toward polar-uncharged residues and cysteine that presumably help in prey-predator interaction by providing particular bonds of attachment.
authors: Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Pondicherry-605014, India. archana@bicpu.edu.in
authors: Archana
authors: A
authors: Pan
authors: Ipsita
authors: I
authors: Chanda
authors: Jayprokas
authors: J
authors: Chakrabarti
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001501:Bdellovibrio / Q000235:genetics* / Q000378:metabolism; D003062:Codon; D022761:Gene Transfer, Horizontal; D016680:Genome, Bacterial; D015999:Multivariate Analysis; D010802:Phylogeny; D014176:Protein Biosynthesis; D017433:Protein Structure, Secondary; D020543:Proteome / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D003062:Codon; D020543:Proteome