title: A dielectric inverse problem applied to human skin measurements during glucose excursions.
abstract: A fringing field capacitive sensor has been used to measure the dielectric properties of human skin and underlying tissue in the MHz frequency range. It has recently been shown in clinical experimental studies that these dielectric properties can be related to the effects of in vivo glucose variations of the test subject. Previously, the relationship between electrical impedance and the glucose level has been established via statistical methods, such as the regression method. In this work, we explored a different approach, namely the resolution of the so-called inverse problem. First we applied the method on an artificial two-layer lossy system in order to test the sensitivity of the solution to forced changes in the layer properties and its stability to a constant setting. After validation of this method on artificial systems, a similar inverse problem was set and solved for dielectric measurements on human skin during an induced glucose excursion, where the skin is also modelled as a double-layer system. The changes of the measured permittivity and conductivity of the second layer versus the glucose changes are calculated for 22 study days. The statistical distribution shows that the median slopes of both dielectric properties are negative. These results can be used to test our hypothesis and to continue building potential explanations for the phenomena induced by the glucose changes on the skin layer dielectric parameters.
authors: Solianis Monitoring AG, Leutschenbachstrasse 46, Zurich 8050, Switzerland.
authors: F
authors: F
authors: Dewarrat
authors: L
authors: L
authors: Falco
authors: M
authors: M
authors: Mueller
authors: S
authors: S
authors: Reinhard
authors: A
authors: A
authors: Caduff
authors: M S
authors: MS
authors: Talary
mesh_terms: D015374:Biosensing Techniques; D003198:Computer Simulation; D004553:Electric Conductivity; D004566:Electrodes; D005260:Female; D005947:Glucose / Q000008:administration & dosage* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012015:Reference Standards; D012867:Skin / Q000187:drug effects*; D012879:Skin Physiological Phenomena / Q000187:drug effects*
chemical_list: D005947:Glucose