title: Identification and analysis of MC4R polymorphisms and their association with economic traits of Korean cattle (Hanwoo).
abstract: Signaling by the melanocortin-4 receptor (MC4R) is important for mediation the effect of leptin on food intake and energy homeostasis, and is associated with obesity, energy homeostasis and control of feeding behavior. Presently, the bovine MC4R gene was characterized to detect genetic variation at this locus and to relate it to economic traits in Korean cattle (Hanwoo). Five single nucleotide polymorphisms (SNPs) were identified in the coding region (G709A, C927T, C1069G, C1343A, and C1786T). G709A changed amino acid 166 of the MC4R protein from valine to methionine and C1069G changed amino acid 286 of the MC4R protein from leucine to valine. A SNP at C927T significantly influenced the Marbling score, SNP markers C1069G and C1343A significantly affected the Backfat thickness, and the SNP marker C1786T significantly influenced backfat and Marbling score. The MC4R gene may thus be a candidate gene for carcass traits with MC4R SNPs being potentially valuable as genetic markers for economic traits in Hanwoo.
authors: Genomic Informatics Center, Hankyong National University, Anseong, 456-749, Republic of Korea. jyseong@hknu.ac.kr
authors: Jiyeon
authors: J
authors: Seong
authors: Dong Sang
authors: DS
authors: Suh
authors: Kyung Do
authors: KD
authors: Park
authors: Hak Kyo
authors: HK
authors: Lee
authors: Hong Sik
authors: HS
authors: Kong
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D005838:Genotype; D016018:Least-Squares Analysis; D008460:Meat / Q000191:economics*; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D019655:Quantitative Trait, Heritable; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D056910:Republic of Korea
chemical_list: D044105:Receptor, Melanocortin, Type 4