title: [Inhibitory effect of GnRHII and GnRH Ia on the stromal cell proliferation from endometriosis patients].
abstract: OBJECTIVE
  To investigate the inhibitory effect of gonadotropin-releasing hormone II(GnRHII) and gonadotropin-releasing hormone I agonist (GnRH Ia) on the proliferation of endometrial stromal cells in vitro from endometriosis patients.
  
  
  METHODS
  Different concentrations of GnRHII or GnRH Ia were added into the cultured endometrial stromal cells in vitro to detect the cell proliferation inhibition by MTT test.
  
  
  RESULTS
  The inhibitory rate of GnRHII or GnRH Ia on eutopic and ectopic endometrial stromal cells in vitro was both dose- and time-dependent (P<0.05). Effect of GnRHII or GnRH Ia on the inhibitory rate of ectopic endometrial stromal cells was significantly higher than that of eutopic (P<0.05). GnRH II had a higher inhibitory rate on the endometrial stromal cells in vitro than did GnRH Ia (P<0.05).
  
  
  CONCLUSIONS
  GnRHII has more antiproliferative effect on endometrial stromal cells than GnRH Ia in vitro, especially on ectopic endometrial stromal cells, suggesting that GnRHII may be more effective than GnRH Ia on endometriosis.
authors: Department of Obstetrics and Gyneology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors: Fengying
authors: F
authors: Huang
authors: Huanping
authors: H
authors: Wang
authors: Mei
authors: M
authors: Wu
authors: Tuanfang
authors: T
authors: Yin
mesh_terms: D000328:Adult; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004715:Endometriosis / Q000473:pathology*; D004717:Endometrium / Q000378:metabolism / Q000473:pathology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000031:analogs & derivatives / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D017154:Stromal Cells / Q000473:pathology*; D055815:Young Adult
chemical_list: D007987:Gonadotropin-Releasing Hormone