title: NLRP3 inflammasomes link inflammation and metabolic disease.
abstract: A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.
authors: Institute of Innate Immunity, University Hospitals, Biomedical Centre, University of Bonn, Germany.
authors: Dominic
authors: D
authors: De Nardo
authors: Eicke
authors: E
authors: Latz
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000639:trends; D058847:Inflammasomes / Q000276:immunology*; D007249:Inflammation; D020382:Interleukin-18 / Q000276:immunology; D053583:Interleukin-1beta / Q000276:immunology*; D008659:Metabolic Diseases / Q000188:drug therapy / Q000276:immunology*; D058990:Molecular Targeted Therapy; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human