title: [Treatment of severe bruxism with botulinum toxin type A].
abstract: BACKGROUND
  The possible usefulness of botulinum toxin type A in the treatment of bruxism has not been studied exhaustively, being limited to some isolated case reports, two short case-series and a double-blind study involving a small number or patients. This article report our long-term experience in the treatment of bruxism with botulinum toxin type A.
  
  
  METHODS
  The outcome of 19 patients with severe bruxism who underwent periodical treatment with botulinum toxin A infiltrations in both temporal and masseter muscles, using initial doses of 25 IU per muscle, during a follow-up period ranging from 0.5 to 11 years, is described. Doses were adjusted in follow-up visits according the response degree.
  
  
  RESULTS
  None of the patients reported side-effects. Final doses ranged from 25 to 40 IU per muscle (mean: 29.7 ± 4.9 UI), and duration of the effect from 13 to 26 weeks (mean: 16.7 ± 5.1 weeks).
  
  
  CONCLUSIONS
  Botulinum toxin A infiltrations are a safe and useful treatment for patients with severe bruxism.
authors: Departamento de Medicina-Neurología, Hospital Príncipe deAsturias, Universidad de Alcalá;Alcalá de Henares, Madrid. hortalon@yahoo.es
authors: Hortensia
authors: H
authors: Alonso-Navarro
authors: Félix J
authors: FJ
authors: Jiménez-Jiménez
authors: José F
authors: JF
authors: Plaza-Nieto
authors: Belén
authors: B
authors: Pilo-De la Fuente
authors: Francisco
authors: F
authors: Navacerrada
authors: Margarita
authors: M
authors: Arroyo-Solera
authors: Marisol
authors: M
authors: Calleja
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019274:Botulinum Toxins, Type A / Q000494:pharmacology / Q000627:therapeutic use*; D002012:Bruxism / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D013703:Temporal Muscle / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A