title: [Cell cycle and molecular targets: CDK inhibition].
abstract: Protein phosphorylation is a fundamental post-translational modification. It regulates a large number of critical cellular processes (differentiation, division, proliferation, apoptosis). Cell division is a process including a series of phases by which a parent cell divides into two daughter cells. The cells enter these stages then progress within the cell division under an accurate control by many proteins. These proteins are activated by phosphorylation. Cyclin-dependent kinases are responsible for this phosphorylation and therefore represent potential therapeutic targets especially in oncology.
authors: HIA Legouest, service de médecine interne, BP 90001, 57077 Metz Cedex 3, France.
authors: Philippe
authors: P
authors: Carassou
authors: Laurent
authors: L
authors: Meijer
authors: Sylvestre
authors: S
authors: Le Moulec
authors: Jean
authors: J
authors: Aoun
authors: Leila
authors: L
authors: Bengrine-Lefèvre
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors* / Q000502:physiology; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D011687:Purines / Q000494:pharmacology*; D000077546:Roscovitine; D013329:Structure-Activity Relationship
chemical_list: C553805:6,6'-dibromoindigo; D007211:Indoles; D047428:Protein Kinase Inhibitors; D011506:Proteins; D011687:Purines; D000077546:Roscovitine; D018844:Cyclin-Dependent Kinases; C027185:indirubin