title: Prediction of outcome in dichorionic twin pregnancies at 6-10 weeks' gestation.
abstract: OBJECTIVE
  The objective of the study was to predict the outcome of dichorionic (DC) twin pregnancies at 6-10 weeks' gestation from intertwin discordance in crown-rump length (CRL), heart rate (HR), and gestational sac diameter (GSD).
  
  
  METHODS
  Intertwin discordance in CRL, HR, and GSD, was compared in 3 groups of DC twin pregnancies with 2 live embryos at 6-10 weeks. In one group, there were 2 live births (n = 174), in another 1 live birth (n = 24), and in a third group there were no live births (n = 33). Regression analysis was used to determine the predictors of outcome.
  
  
  RESULTS
  Significant contributors to the prediction of 1 intrauterine death were discordance in CRL and GSD. The only predictor of 2 deaths was discordance in CRL. Detection rates of screening for single or double death, at 10% false-positive rate, were 79.2% and 27.3%, respectively.
  
  
  CONCLUSIONS
  In DC twins, intertwin discordance in CRL and GSD at 6-10 weeks can predict outcome.
authors: Fetal Medicine Unit, King's College Hospital, London, England, UK. papaioannougk@gmail.com
authors: George I
authors: GI
authors: Papaioannou
authors: Argyro
authors: A
authors: Syngelaki
authors: Nerea
authors: N
authors: Maiz
authors: Jackie A
authors: JA
authors: Ross
authors: Kypros H
authors: KH
authors: Nicolaides
mesh_terms: D000328:Adult; D018568:Crown-Rump Length; D005260:Female; D005865:Gestational Age; D058746:Gestational Sac / Q000033:anatomy & histology* / Q000648:ultrastructure*; D006339:Heart Rate; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D016216:Ultrasonography, Prenatal