title: Anticomplement activity of organic solvent extracts from Korea local Amarantaceae spp.
abstract: The study evaluated the anticomplement activity from various solvent extracts of nine Amarantaceae plants (Achyranthes japonica (Miq.) Nakai, Amaranthus mangostanus L., Amaranthus retroflexus L., Amaranthus spinosus L., Celosia argentea var. spicata., Amaranthus lividus L., Celosia cristata L., Amaranthus viridis L., Gomphrena globosa L.) from South Korea on the classical pathway. We have evaluated various organic solvent extract from nine Amarantaceae plants with regard to its anticomplement activity on the classical pathway. Achyranthes japonica chloroform extracts showed inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) value of 73.1μg/ml. This is the first report of anticomplement activity from Amarantaceae plants.
authors: Department of Urology, College of Medicine, Dong-A University, Busan 602-714, South Korea.
authors: Seil
authors: S
authors: Jung
authors: Jai-Heon
authors: JH
authors: Lee
authors: Young-Choon
authors: YC
authors: Lee
authors: Hyung-In
authors: HI
authors: Moon
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D051056:Complement Inactivating Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003171:Complement Pathway, Classical / Q000187:drug effects* / Q000276:immunology; D006461:Hemolysis / Q000276:immunology; D020128:Inhibitory Concentration 50; D009930:Organic Chemicals / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D056910:Republic of Korea; D012756:Sheep; D012997:Solvents / Q000737:chemistry*
chemical_list: D051056:Complement Inactivating Agents; D009930:Organic Chemicals; D010936:Plant Extracts; D012997:Solvents