title: Quantitative calculation of human melatonin suppression induced by inappropriate light at night.
abstract: Melatonin (C₁₃H₁₆N₂O₂) has a wide range of functions in the body. When is inappropriately exposed to light at night, human circadian rhythm will be interfered and then melatonin secretion will become abnormal. For nearly three decades great progresses have been achieved in analytic action spectra and melatonin suppression by various light conditions. However, so far few articles focused on the quantitative calculation of melatonin suppression induced by light. In this article, an algorithm is established, in which all the contributions of rods, cones, and intrinsically photosensitive retinal ganglion cells are considered. Calculation results accords with the experimental data in references very well, which indicate the validity of this algorithm. This algorithm can also interpret the rule of melatonin suppression varying with light correlated color temperature very well.
authors: Photonics Research Center, School of Physics, Nankai University, Tianjin 300071, China.
authors: Yang
authors: Y
authors: Meng
authors: Zhenni
authors: Z
authors: He
authors: Jian
authors: J
authors: Yin
authors: Yu
authors: Y
authors: Zhang
authors: Tianhao
authors: T
authors: Zhang
mesh_terms: D000465:Algorithms; D002940:Circadian Rhythm / Q000502:physiology / Q000528:radiation effects*; D006801:Humans; D008029:Lighting; D008550:Melatonin / Q000378:metabolism*; D008954:Models, Biological; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology / Q000528:radiation effects; D012165:Retinal Ganglion Cells / Q000502:physiology / Q000528:radiation effects; D017948:Retinal Rod Photoreceptor Cells / Q000502:physiology / Q000528:radiation effects
chemical_list: D008550:Melatonin