title: Regional and mucosal memory T cells.
abstract: After infection, most antigen-specific memory T cells reside in nonlymphoid tissues. Tissue-specific programming during priming leads to directed migration of T cells to the appropriate tissue, which promotes the development of tissue-resident memory in organs such as intestinal mucosa and skin. Mechanisms that regulate the retention of tissue-resident memory T cells include transforming growth factor-β (TGF-β)-mediated induction of the E-cadherin receptor CD103 and downregulation of the chemokine receptor CCR7. These pathways enhance protection in internal organs, such as the nervous system, and in the barrier tissues--the mucosa and skin. Memory T cells that reside at these surfaces provide a first line of defense against subsequent infection, and defining the factors that regulate their development is critical to understanding organ-based immunity.
authors: Center for Integrated Immunology and Vaccine Research, Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut, USA. bsheridan@uchc.edu
authors: Brian S
authors: BS
authors: Sheridan
authors: Leo
authors: L
authors: Lefrançois
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D039001:Integrin alpha Chains / Q000276:immunology / Q000378:metabolism; D018448:Models, Immunological; D009092:Mucous Membrane / Q000276:immunology*; D054400:Receptors, CCR7 / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000276:immunology / Q000378:metabolism
chemical_list: D000941:Antigens; D015703:Antigens, CD; D039001:Integrin alpha Chains; D054400:Receptors, CCR7; D016212:Transforming Growth Factor beta; C091367:alpha E integrins