title: [Oligo(2'-O-methylribonucleotides) with the insertions of 2'-bispyrenylmethylphosphorodiamidate nucleoside derivatives as perspective fluorescent probes for RNA detection].
abstract: A series of novel fluorescent conjugates of oligo(2'-O-methylribonucleotides) containing the insertions of 2'bispyrenylmethylphosphorodiamidate derivatives of ribonucleosides (Urd, Cyd) were synthesized and their fluorescent properties were investigated. The possibility of detection of RNA transcript of 5'-terminal fragment of mRNA of multidrug resistance gene mdr1 (1-678) in solution using synthesized multipyrene probes was demonstrated.
authors: O A
authors: OA
authors: Krasheninina
authors: D S
authors: DS
authors: Novopashina
authors: A G
authors: AG
authors: Ven'iaminova
mesh_terms: D024506:5' Flanking Region / Q000235:genetics; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000818:Animals; D003562:Cytidine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D018432:Drug Resistance, Multiple / Q000235:genetics*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006801:Humans; D066298:In Vitro Techniques; D016254:Mutagenesis, Insertional; D015345:Oligonucleotide Probes / Q000138:chemical synthesis*; D057089:Pathology, Molecular; D012333:RNA, Messenger / Q000032:analysis*; D014529:Uridine / Q000031:analogs & derivatives / Q000138:chemical synthesis
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D005456:Fluorescent Dyes; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D003562:Cytidine; D014529:Uridine