title: Enhanced glutathione peroxidase activity of conformationally restricted naphthalene peri-dichalcogenides.
abstract: Conformationally restricted naphthalene peri-diselenides function as glutathione peroxidase mimetics with superior catalytic activity to that displayed by typical acyclic diaryl diselenides. Their activity was increased by electron-donating methoxy substituents, while a further 100-fold increase was observed with the corresponding ditelluride.
authors: Department of Chemistry, University of Calgary, Calgary, Alberta, Canada, T2N 1N4.
authors: David J
authors: DJ
authors: Press
authors: Thomas G
authors: TG
authors: Back
mesh_terms: D055162:Biocatalysis; D018011:Chalcogens / Q000737:chemistry* / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000378:metabolism*; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry*
chemical_list: D018011:Chalcogens; D009281:Naphthalenes; C031721:naphthalene; D005979:Glutathione Peroxidase