title: The efficacy of romiplostim in the treatment of severe thrombocytopenia associated to Evans syndrome refractory to rituximab.
abstract: We present a case of a man diagnosed with systemic lupus erythematosus, associated antiphospholipid syndrome and Evans syndrome, who developed a severe thrombocytopenia refractory to treatment with first-line drugs, cyclophosphamide and rituximab, and who responded to romiplostim with a normalization of the platelet recount, which later enabled a therapeutic splenectomy to be performed.
authors: Autoimmune Diseases Unit, Internal Medicine Department, Juan Ramón Jimenez Hospital, Huelva, Spain.
authors: J A
authors: JA
authors: Gonzalez-Nieto
authors: I
authors: I
authors: Martin-Suarez
authors: S
authors: S
authors: Quattrino
authors: E
authors: E
authors: Ortiz-Lopez
authors: F R
authors: FR
authors: Muñoz-Beamud
authors: J
authors: J
authors: Colchero-Fernández
authors: M R
authors: MR
authors: Alcoucer-Diaz
mesh_terms: D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000601:surgery; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy; D008297:Male; D010976:Platelet Count; D011961:Receptors, Fc / Q000627:therapeutic use*; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use*; D000069283:Rituximab; D013156:Splenectomy; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000209:etiology* / Q000601:surgery; D013926:Thrombopoietin / Q000627:therapeutic use*
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D011961:Receptors, Fc; D011993:Recombinant Fusion Proteins; D000069283:Rituximab; D003520:Cyclophosphamide; D013926:Thrombopoietin; C488777:romiplostim