title: Inhibition by wheat sprout (Triticum aestivum) juice of bisphenol A-induced oxidative stress in young women.
abstract: For health of future generation, fertile young women should be monitored for exposure of endocrine disrupting chemicals (EDCs). Among EDCs, bisphenol A (BPA) is suggested to induce reactive oxygen species (ROS) which play an important role in pathologies of female diseases such as endometriosis. On the other hand, previous studies suggested that sprouts of wheat (Triticum aestivum) have antimutagenicity and antioxidant activity. We performed the 2 weeks intervention of wheat sprout juice (100ml/day) to investigate its effects on BPA-exposure and -oxidative toxicity in young women (N=14, age=24.4±4.0). Geometrical mean of urinary BPA levels was 1.81 (GSTD, 4.34)μg/g creatinine. We observed that irregular meals significantly increased levels of urinary BPA approximate 3 times (p=0.03). In addition, we found BPA-induced oxidative stress is correlated with levels of 8-hydroxydeoxyguanosine (8-OHdG) or malondialdehyde (MDA) levels (p=0.18 or 0.03, respectively). We also observed a continuous reduction of urinary BPA during the wheat sprout intervention (p=0.02). In summary, our data suggested potential detoxification of wheat sprouts on BPA-toxicity via antioxidative and interference of absorption, distribution, metabolism and excretion (ADME)-mediated mechanisms in young women.
authors: Sookmyung Women's University, College of Pharmacy, Seoul 140-742, Republic of Korea.
authors: Bitna
authors: B
authors: Yi
authors: Hiroshi
authors: H
authors: Kasai
authors: Ho-Sun
authors: HS
authors: Lee
authors: Yunkyeong
authors: Y
authors: Kang
authors: Jong Y
authors: JY
authors: Park
authors: Mihi
authors: M
authors: Yang
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D001559:Benzhydryl Compounds; D004249:DNA Damage / Q000187:drug effects; D052244:Endocrine Disruptors / Q000494:pharmacology*; D005260:Female; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000652:urine; D010936:Plant Extracts / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014908:Triticum / Q000737:chemistry*; D055815:Young Adult; D000098826:Bisphenol A Compounds
chemical_list: D000975:Antioxidants; D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C006780:bisphenol A; D000098826:Bisphenol A Compounds