title: Improved diagnostic and prognostic performance of a new high-sensitive troponin T assay in patients with acute coronary syndrome.
abstract: BACKGROUND
  In the present study, we aimed to analyze the diagnostic and prognostic potential of a newly developed high-sensitive troponin T assay and compared these results with those of a contemporary troponin T assay in 2 distinct patient cohorts, one including patients with evident ACS and the other one including patients with general chest pain.
  
  
  RESULTS
  For this study, we analyzed data from 2 independent patient cohorts, the Bad Nauheim ACS registry and the Prognosis in Acute Coronary Syndromes registry, with a total of 2,506 patients. On admission, clinical data have been recorded, and a single measurement of troponin T has been performed with a contemporary assay (TnT) and a new high-sensitive troponin T assay (hsTnT). Clinical follow-up has been obtained after 6 months. The diagnostic value of hsTnT was superior to TnT (area under the receiver operating characteristic curve 0.949 vs 0.929, P = .016). Specifically, in TnT-negative patients, hsTnT provided strong diagnostic information (area under the receiver operating characteristic curve of 0.81, P < .001). Furthermore, hsTnT provided independent prognostic power for mortality within 6 months in both cohorts, which was superior to that of the contemporary TnT assay.
  
  
  CONCLUSIONS
  Troponin T measured with a newly developed hsTnT provides better diagnostic and prognostic information and, therefore, should be implemented as a standard test in clinical routine.
authors: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany. M.Weber@Kreiskliniken-dadi.de
authors: Michael
authors: M
authors: Weber
authors: Oscar
authors: O
authors: Bazzino
authors: Jose Luis
authors: JL
authors: Navarro Estrada
authors: Raul
authors: R
authors: de Miguel
authors: Simon
authors: S
authors: Salzberg
authors: Juan J
authors: JJ
authors: Fuselli
authors: Christoph
authors: C
authors: Liebetrau
authors: Mariella
authors: M
authors: Woelken
authors: Helge
authors: H
authors: Moellmann
authors: Holger
authors: H
authors: Nef
authors: Christian
authors: C
authors: Hamm
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis*; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012042:Registries; D012189:Retrospective Studies; D012720:Severity of Illness Index; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T