title: Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides.
abstract: A chemoenzymatic method was developed for the synthesis of macrocyclic peptides and glycopeptides. Sortase A was found to mediate either head to tail cyclization or oligomerization and then head to tail cyclization of peptides and glycopeptides, depending on the peptide length, to produce 15-mer or higher cyclic peptides and glycopeptides.
authors: Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
authors: Zhimeng
authors: Z
authors: Wu
authors: Xueqing
authors: X
authors: Guo
authors: Zhongwu
authors: Z
authors: Guo
mesh_terms: D000595:Amino Acid Sequence; D019881:Aminoacyltransferases / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D003500:Cyclization; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000201:enzymology*; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D006020:Glycopeptides; D010456:Peptides, Cyclic; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases