title: [Methoxymethyl and (p-nitrobenzyloxy)methyl groups in the synthesis of oligoribonucleotides by the phosphotriester method].
abstract: An efficient synthetic method for monomer ribonucleotide synthons containing 2'-O-methoxymethyl and 2'O-(p-nitrobenzyloxy)methyl groups used for oligonucleotide phosphotriester method with O-nucleophilic intramolecular catalysis at the stage of formation of internucleotide bond is developed. It is shown that synthons containing protecting 2'-O-(p-nitrobenzyloxy)methyl group may be used for automatic synthesis of phosphotriester oligoribonucleotides with high yields and synthons containing methoxymethyl group--to get 2'-O-modified oligonucleotides.
authors: V A
authors: VA
authors: Efimov
authors: A V
authors: AV
authors: Aralov
authors: O G
authors: OG
authors: Chakhmakhcheva
mesh_terms: D000818:Animals; D002384:Catalysis; D006801:Humans; D008738:Methyl Ethers / Q000138:chemical synthesis*; D008967:Molecular Biology / Q000379:methods; D009578:Nitrobenzenes / Q000138:chemical synthesis*; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D044345:Phosphoric Triester Hydrolases / Q000378:metabolism*
chemical_list: D008738:Methyl Ethers; D009578:Nitrobenzenes; D009843:Oligoribonucleotides; D044345:Phosphoric Triester Hydrolases