title: A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production.
abstract: A number of 8-substituted chrysin analogs have been prepared and evaluated for their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E(2) and iNOS-mediated NO production. Analogs were prepared via Suzuki-Miyaura C-C cross coupling reaction of 8-iodo-5,7-dimethoxyflavone and alkyl/areneboronic acids as a key reaction. Among the analogs tested, 5,7-dihydroxy-8-(pyridine-4-yl)flavone (3d) showed strong biological activities against COX-2 catalyzed PGE(2) and iNOS-mediated NO production from LPS-induced RAW 264.7 cells compared to those of chrysin.
authors: College of Pharmacy, Kangwon National University, 192-1 Hyoja-2-dong, Chuncheon 200-701, Republic of Korea.
authors: Haiyan
authors: H
authors: Che
authors: Hyun
authors: H
authors: Lim
authors: Hyun Pyo
authors: HP
authors: Kim
authors: Haeil
authors: H
authors: Park
mesh_terms: D000818:Animals; D002384:Catalysis; D002460:Cell Line; D015232:Dinoprostone / Q000037:antagonists & inhibitors*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D005419:Flavonoids; D008070:Lipopolysaccharides; D009569:Nitric Oxide; C043561:chrysin; D015232:Dinoprostone