title: Neuromagnetic cerebellar activation during seizures arising from the motor cortex.
abstract: We utilized the high temporal resolution, whole head coverage and novel analysis methodology of magnetoencephalography (MEG) to record the dynamics of cerebellar activation during focal motor seizures. We analyzed ictal MEG data from a four-year old using an event-related beamformer to localize and display ictal changes over the motor cortex and cerebellum. Contralateral activation of the cerebellum was seen 14s after MEG ictal onset over the motor cortex. These findings represent the first indication of ictal activity within the cerebellum in humans, measured non-invasively with MEG.
authors: Department of Pediatrics, IWK Health Center, Dalhousie University, 5850/5980 University Ave., Halifax, NS, Canada. ismailsidky@pol.net
authors: Ismail S
authors: IS
authors: Mohamed
authors: Hiroshi
authors: H
authors: Otsubo
authors: Paul
authors: P
authors: Ferrari
authors: Ayako
authors: A
authors: Ochi
authors: O Carter
authors: OC
authors: Snead
authors: Douglas
authors: D
authors: Cheyne
mesh_terms: D002531:Cerebellum / Q000503:physiopathology*; D002675:Child, Preschool; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery; D019054:Evoked Potentials, Motor; D005073:Evoked Potentials, Somatosensory; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology*