title: Contrast enhancement of the inner ear after intravenous administration of a standard or double dose of gadolinium contrast agents.
abstract: CONCLUSIONS
  Imaging of the endolymphatic space was possible in most cases after administering a standard dose of gadolinium (Gd) by using heavily T2-weighted 3D fluid-attenuated inversion recovery (hT(2)W-3D-FLAIR) magnetic resonance imaging (MRI).
  
  
  OBJECTIVE
  The aim of this study was to characterize the contrast enhancement in the inner ear after intravenous injection of Gd and to compare the signal intensity after a double dose or standard dose of Gd.
  
  
  METHODS
  We injected a standard dose of gadodiamide hydrate (DTPA-BMA) or a double dose of gadoteridol (HP-DO3A) intravenously in patients affected by Meniere's disease and performed hT(2)W-3D-FLAIR 3 T MRI. Contrast enhancement of the basal turn of the cochlea was evaluated semiquantitatively.
  
  
  RESULTS
  Endolymphatic hydrops was observed in the cochlea and vestibule of the affected ears of patients with Meniere's disease in both the double-dose group and the standard-dose group.
authors: Department of Otorhinolaryngology, Nagoya University, Graduate School of Medicine, Japan.
authors: Hirokazu
authors: H
authors: Suzuki
authors: Masaaki
authors: M
authors: Teranishi
authors: Michihiko
authors: M
authors: Sone
authors: Masahiro
authors: M
authors: Yamazaki
authors: Shinji
authors: S
authors: Naganawa
authors: Tsutomu
authors: T
authors: Nakashima
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006571:Heterocyclic Compounds / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008575:Meniere Disease / Q000473:pathology*; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage; D010498:Perilymph; D055815:Young Adult
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; C064925:gadodiamide; D005682:Gadolinium; D019786:Gadolinium DTPA