title: Serum kisspeptin levels in Korean girls with central precocious puberty.
abstract: Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by investigating serum kisspeptin levels in Korean girls with CPP and their prepubertal controls. Serum kisspeptin levels of Korean girls with CPP (n = 30) and age-matched healthy prepubertal controls (n = 30) were measured with a competitive enzyme immunoassay. Serum kisspeptin levels were significantly higher in CPP group than in control group (4.61 ± 1.78 vs 2.15 ± 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation test. CPP is supposed to be triggered by premature increase of kisspeptin. Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed.
authors: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors: Young Jun
authors: YJ
authors: Rhie
authors: Kee Hyoung
authors: KH
authors: Lee
authors: So Hee
authors: SH
authors: Eun
authors: Byung Min
authors: BM
authors: Choi
authors: Hyun Wook
authors: HW
authors: Chae
authors: Ah Reum
authors: AR
authors: Kwon
authors: Woo Jung
authors: WJ
authors: Lee
authors: Jung Hyun
authors: JH
authors: Kim
authors: Ho-Seong
authors: HS
authors: Kim
mesh_terms: D015415:Biomarkers / Q000097:blood; D002648:Child; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D059648:Kisspeptins; D007986:Luteinizing Hormone / Q000097:blood; D011629:Puberty, Precocious / Q000097:blood / Q000175:diagnosis*; D056910:Republic of Korea; D025521:Tumor Suppressor Proteins / Q000097:blood*
chemical_list: D015415:Biomarkers; C106628:KISS1 protein, human; D059648:Kisspeptins; D025521:Tumor Suppressor Proteins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone