title: Field study on the efficacy of an oral 2% ivermectin formulation in horses.
abstract: Twenty horses naturally infected with nematodes were included in a blind, controlled field study on efficacy and safety of an oral 2% ivermectin formulation at a dose of 0.2 mg.kg(-1). Horses were divided into treated and non-treated (control) groups with ten animals each based on preliminary counts of eggs per gram of feces (EPG). Stool samples were collected after treatment for identification of nematode species. Clinical evaluations and EPG counts were performed on days 0, +5, +14 and +19. Nineteen nematode species were identified: Coronocyclus ulambajari, Craterostomum acuticaudatum, Cyathostomum catinatum, Cyathostomum pateratum, Cylicocyclus brevicapsulatus, Cylicocyclus insigne, Cylicocyclus leptostomum, Cylicocyclus nassatus, Cylicocyclus ultrajectinus, Cylicocyclus spp., Cylicostephanus calicatus, Cylicostephanus longibursatus, Cylicostephanus poculatus, Habronema muscae, Habronema spp., Parascaris equorum, Poteriostomum imparidentatum, Oxyuris equi and Triodontophorus spp. The mean EPG counts of treated and non-treated (control) groups on Days �15, 0, +5, +14 and +19 were 1925, 1340, 0, 12.5, 0, 1470, 790, 875, 1605 and 1240 respectively. The efficacy of treatment on Days +5, +14 and +19 was 100, 99.2 and 100% respectively, with a significant difference compared to the control group (p < 0.01). The product was considered to be safe with no findings of clinical significant changes during the study.
authors: Departamento de Biologia Animal, Instituto de Biologia, Universidade Estadual de Campinas, Cidade Universitária Zeferino Vaz, Rua Monteiro Lobato 255, Campinas, SP, Brazil. cutoloandre@yahoo.com
authors: André Antonio
authors: AA
authors: Cutolo
authors: Anderson Tintino dos
authors: AT
authors: Santos
authors: Silmara Marques
authors: SM
authors: Allegretti
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage*; D006374:Helminthiasis, Animal / Q000188:drug therapy*; D006734:Horse Diseases / Q000188:drug therapy* / Q000469:parasitology*; D006736:Horses; D007559:Ivermectin / Q000008:administration & dosage*
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin