title: Rapid quantification of myocardial lipid content in humans using single breath-hold 1H MRS at 3 Tesla.
abstract: A rapid, proton magnetic resonance spectroscopy method to evaluate human myocardial lipid levels in a single breath-hold at 3 T using a commercial whole-body system is presented. During a 10 s breath-hold, water unsuppressed and suppressed spectra were acquired by two phased array coils using a short-echo time spectroscopic stimulated echo (STEAM) sequence electrocardiogram-triggered to mid-diastole. Lipid-to-water ratios were obtained in the septum of 15 healthy volunteers, (0.46 ± 0.19)%. These results agreed well with ratios obtained from averaged spectra acquired in seven multiple breath-holds, (0.45 ± 0.20)%, providing increased signal-to-noise ratio but requiring longer acquisition times. Excellent correlation was found between the two methods (r=0.94, P<0.05). Reproducibility of (1)H MRS for measuring myocardial lipid levels in a short breath-hold was acceptable in five repeated measurements within the same subject (coefficient of variation=19%). Thus, single breath-hold proton spectroscopy allows reliable and quick quantification of myocardial lipids at 3 T.
authors: Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.
authors: Belen
authors: B
authors: Rial
authors: Matthew D
authors: MD
authors: Robson
authors: Stefan
authors: S
authors: Neubauer
authors: Jürgen E
authors: JE
authors: Schneider
mesh_terms: D000328:Adult; D000465:Algorithms; D015415:Biomarkers / Q000032:analysis; D055424:Cardiac-Gated Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted
chemical_list: D015415:Biomarkers; D008055:Lipids