title: Use of the state immunization information system to assess rotavirus vaccine effectiveness in Connecticut, 2006-2008.
abstract: Immunization information systems (IIS) contain individual vaccination records and have potential use for evaluating post-licensure vaccine effectiveness (VE). A matched case-control study was performed by using the Connecticut state IIS to calculate rotavirus VE against hospitalization; results were compared with pre-licensure efficacy and with estimates previously obtained by traditional case-control methods using matched controls from medical sources and medical chart abstracted data. Case-patients (n=54) were vaccine-eligible children with IIS entry and hospitalized for rotavirus gastroenteritis during July 2006-December 2008; each was matched to five control subjects (n=270) who were randomly selected from IIS based on case-patient's birth date and town of residence. VE of at least one dose was 90.6%, comparable to the pre-licensure efficacy of 96% and to the unadjusted 83.5-90.7% estimates by using traditional case-control methods. IIS can be a convenient and potentially accurate tool for calculating VE.
authors: Epidemic Intelligence Service, Centers for Disease Control and Prevention, 1600 Clifton Rd., NE, MS E-92, Atlanta, GA 30329, USA. ggt4@cdc.gov
authors: Alice Y
authors: AY
authors: Guh
authors: James L
authors: JL
authors: Hadler
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D003237:Connecticut / Q000453:epidemiology; D057286:Electronic Health Records; D005260:Female; D005759:Gastroenteritis / Q000821:virology; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007256:Information Systems; D008297:Male; D012400:Rotavirus Infections / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D014481:United States / Q000453:epidemiology; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology / Q000627:therapeutic use
chemical_list: D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated