title: Glucagon-like peptide-1, diabetes, and cognitive decline: possible pathophysiological links and therapeutic opportunities.
abstract: Metabolic and neurodegenerative disorders have a growing prevalence in Western countries. Available epidemiologic and neurobiological evidences support the existence of a pathophysiological link between these conditions. Glucagon-like peptide 1 (GLP-1), whose activity is reduced in insulin resistance, has been implicated in central nervous system function, including cognition, synaptic plasticity, and neurogenesis. We review the experimental researches suggesting that GLP-1 dysfunction might be a mediating factor between Type 2 diabetes mellitus (T2DM) and neurodegeneration. Drug treatments enhancing GLP-1 activity hold out hope for treatment and prevention of Alzheimer's disease (AD) and cognitive decline.
authors: Unit of Gerontology and Geriatric Medicine, Department of Critical Care Medicine and Surgery, University of Florence and Careggi Teaching Hospital, 50121 Florence, Italy. enrico.mossello@unifi.it
authors: Enrico
authors: E
authors: Mossello
authors: Elena
authors: E
authors: Ballini
authors: Marta
authors: M
authors: Boncinelli
authors: Matteo
authors: M
authors: Monami
authors: Giuseppe
authors: G
authors: Lonetto
authors: Anna Maria
authors: AM
authors: Mello
authors: Francesca
authors: F
authors: Tarantini
authors: Samuele
authors: S
authors: Baldasseroni
authors: Edoardo
authors: E
authors: Mannucci
authors: Niccolò
authors: N
authors: Marchionni
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology*; D004704:Endocrinology / Q000379:methods / Q000639:trends; D052216:Glucagon-Like Peptide 1 / Q000172:deficiency / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D009410:Nerve Degeneration / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D035703:Therapies, Investigational / Q000379:methods / Q000639:trends
chemical_list: D052216:Glucagon-Like Peptide 1