title: Molecular dynamics simulation of the enhancement of cobra cardiotoxin and E6 protein binding on mixed self-assembled monolayer molecules.
abstract: Molecular dynamics simulations are performed on n-alkinethiol self-assembled monolayers (SAMs) and their mixture on a gold surface so that the orientations of the binding of cobra cardiotoxin and E6 protein molecules can be selected using the mixing ratio of CH3-terminated SAMs with different chain lengths. The simulations suggest that a SAM surface with different mixing ratios may provide a possible platform for aligning protein molecules with a desired orientation and for enhancing the binding energy of the protein on the designed surface.
authors: Department of Engineering and System Science, National Tsing Hua University, Hsinchu 300, Taiwan.
authors: Shih-Wei
authors: SW
authors: Hung
authors: Jenn-Kang
authors: JK
authors: Hwang
authors: Fangang
authors: F
authors: Tseng
authors: Joe-Ming
authors: JM
authors: Chang
authors: Chih-Chieh
authors: CC
authors: Chen
authors: Ching-Chang
authors: CC
authors: Chieng