title: Association of a functional polymorphism in the MMP7 gene promoter with susceptibility to vulnerable carotid plaque in a Han Chinese population.
abstract: BACKGROUND
  Matrix metalloproteinase-7 (MMP-7) may play an important role in the development of vulnerable carotid plaque. An A-to-G transition (-181A/G) in the promoter region of MMP7 is functional in vitro by altering the transcriptional activity of the gene. The aim of this study was to investigate the association between the MMP7 -181A/G polymorphism and vulnerable carotid plaque formation.
  
  
  METHODS
  The authors enrolled 641 patients and divided them into three groups according to the carotid ultrasound examination: vulnerable plaque group (n=118), stable plaque group (n=385) and no plaque group (n=138). Traditional atherosclerosis risk factors were recorded and the MMP7 -181A/G polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  In the multinomial logistic regression analysis, compared to the no plaque group, no relationship between MMP7 -181AG+GG genotypes and stable carotid plaque was observed [odds ratio (OR) 1.50; p=0.239]. However, the frequency of AG+GG genotypes was significantly higher in the vulnerable plaque group (OR 2.74; p=0.008). Age was a risk factor for plaque formation, while statin treatment can reduce the prevalence of atherosclerotic plaque. Additionally, using binary logistic regression analysis between the stable and vulnerable plaque groups, this MMP7 polymorphism was associated with vulnerable plaque independently of other factors [OR 1.83; 95% confidence interval 1.08- 3.11; p=0.026].
  
  
  CONCLUSIONS
  The MMP7 -181A/G polymorphism is associated with the development of vulnerable carotid plaques. Age is a risk factor for plaque formation, while statin therapy is associated with a decreased prevalence of carotid atheromatous plaques.
authors: Department of Neurology, Taizhou Hospital, Affiliated Hospital of Wenzhou Medical College, Taizhou, Zhejiang, PR China.
authors: Xiao-Fei
authors: XF
authors: Hu
authors: Xiao-Ping
authors: XP
authors: Jin
authors: Pei-Yang
authors: PY
authors: Hu
authors: Min
authors: M
authors: Zhu
authors: Feng
authors: F
authors: Wang
authors: Xian-Fang
authors: XF
authors: Lin
authors: Wei-Ling
authors: WL
authors: Li
authors: Hong
authors: H
authors: Ni
authors: Li-Hua
authors: LH
authors: Yang
mesh_terms: D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000235:genetics*; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012015:Reference Standards
chemical_list: C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7