title: Treatment of gingival recession defects using coronally advanced flap with a porcine collagen matrix compared to coronally advanced flap with connective tissue graft: a randomized controlled clinical trial.
abstract: BACKGROUND
  Connective tissue graft (CTG) plus coronally advanced flap (CAF) is the reference therapy for root coverage. The aim of the present study is to evaluate the use of a porcine collagen matrix (PCM) plus CAF as an alternative to CTG+CAF for the treatment of gingival recessions (REC), in a prospective randomized, controlled clinical trial.
  
  
  METHODS
  Eighteen adult patients participated in this study. The patients presented 22 single Miller's Class I or II REC, randomly assigned to the test (PCM+CAF) or control (CTG+CAF) group. REC, probing depth, clinical attachment level (CAL), and width of keratinized tissue (KG) were evaluated at 12 months. In addition, the gingival thickness (GT) was measured 1mm apical to the bottom of the sulcus.
  
  
  RESULTS
  At 12 months, mean REC was 0.23 mm for test sites and 0.09 mm for control sites (P <0.01), whereas percentage of root coverage was 94.32% and 96.97%, respectively. CAL gain was 2.41 mm in test sites and 2.95 mm in control sites (P <0.01). KG gain was 1.23 mm in the test group and 1.27 mm in the control group (P <0.01). In test sites, GT changed from 0.82 to 1.82 mm, and in control sites, from 0.86 to 2.09 mm (P <0.01).
  
  
  CONCLUSIONS
  Within the limits of the study, both treatment procedures resulted in significant reduction in REC at 12 months. No statistically significant differences were found between PCM+CAF and CTG+CAF with regard to any clinical parameter. The collagen matrix represents a possible alternative to CTG.
authors: PROED Professional Education in Dentistry, Turin, Italy. dacardar@tin.it
authors: Daniele
authors: D
authors: Cardaropoli
authors: Lorenzo
authors: L
authors: Tamagnone
authors: Alessandro
authors: A
authors: Roffredo
authors: Lorena
authors: L
authors: Gaveglio
mesh_terms: D000328:Adult; D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D024042:Collagen Type I / Q000627:therapeutic use; D024061:Collagen Type III / Q000627:therapeutic use; D003238:Connective Tissue / Q000637:transplantation; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000473:pathology / Q000637:transplantation*; D005889:Gingival Recession / Q000145:classification / Q000601:surgery*; D006801:Humans; D007633:Keratins; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D011446:Prospective Studies; D013524:Surgical Flaps; D013552:Swine; D014092:Tooth Root / Q000473:pathology / Q000601:surgery; D055815:Young Adult
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III; D008567:Membranes, Artificial; D007633:Keratins; D003094:Collagen