title: Positive association of pro-inflammatory biomarkers and increased oxidative stress in the healthy elderly.
abstract: To investigate the relationship between oxidative stress and pro-inflammatory status in healthy elderly people. A total of 1205 healthy elderly Chinese people (age: 65-83 years old; 861 males, 344 females) who visited the Geriatric Department for a thorough physical examination between May 20 and July 23, 2008 were screened and 118 of them were recruited for further evaluation of oxidative stress (total antioxidation capacity, superoxide dismutase (SOD) activity, xanthine oxidase (XO) activity and serum hydrogen peroxide (H(2)O(2)) level) and pro-inflammatory status (serum C-reactive protein (CRP) and interleukin-6 (IL-6) level). The total anti-oxidation capacity and SOD activity were decreased while the serum H(2)O(2) level and XO activity were elevated in groups with higher CRP or IL-6 level. Linear stepwise regression showed that body mass index (BMI), total antioxidation capacity, SOD activity, H(2)O(2) level and XO activity were predictors for CRP level, while age, BMI, H(2)O(2) level and XO activity were predictors for IL-6 level. Pro-inflammatory status is associated with increased oxidative stress in healthy elderly population.
authors: Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. katharinehong@163.com
authors: Hong
authors: H
authors: Liu
authors: Yu
authors: Y
authors: Yang
authors: Guxiang
authors: G
authors: Huang
authors: Shengyu
authors: S
authors: Tan
authors: Yun
authors: Y
authors: Liu
mesh_terms: D000367:Age Factors; D000368:Aged / Q000502:physiology*; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D007249:Inflammation / Q000097:blood* / Q000503:physiopathology; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase