title: The possibilities of practical application of transgenic mammalian species generated by somatic cell cloning in pharmacology, veterinary medicine and xenotransplantology.
abstract: Cloning of genetically-modified mammals to produce: 1) novel animal bioreactors expressing human genes in rens, urinary bladder and the male accessory sex glands, as well as 2) porcine organs suitable in pig-to-human xenotransplantology, could offer new advantages for biomedical purposes. So too does the generation and/or multiplication of genetically-engineered cloned animals in order to produce: 3) physiologically-relevant animal models of serious monogenic human diseases and 4) prion disease-resistant small as well as large animals (i.e., rodents, ruminants). The basic purpose of this paper is to overview current knowledge deciphering the possibilities of using transgenic specimens created by somatic cell nuclear transfer in medical pharmacology, veterinary medicine, agriculture, transplantational medicine and immunology.
authors: National Research Institute of Animal Production, Department of Biotechnology of Animal Reproduction, Krakowska 1, 32-083 Balice n. Kraków, Poland. msamiec@izoo.krakow.pl
authors: M
authors: M
authors: Samiec
authors: M
authors: M
authors: Skrzyszowska
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D019976:Cloning, Organism / Q000379:methods*; D008322:Mammals / Q000235:genetics*; D010600:Pharmacology / Q000379:methods*; D014183:Transplantation, Heterologous; D014730:Veterinary Medicine