title: Better prognosis for patients with del(7q) than for patients with monosomy 7 in myelodysplastic syndrome.
abstract: BACKGROUND
  Abnormalities involving chromosome 7 are frequent in myelodysplastic syndrome (MDS) and suggest a poor prognosis.
  
  
  METHODS
  The authors examined the hypothesis that the clinical features and survival associated with isolated deletion (del) of part of the long arm of chromosome 7 (7q) in MDS are different from those associated with isolated monosomy 7 (complete loss of chromosome 7). In total, 133 patients with a diagnosis of de novo MDS (according to the World Health Organization [WHO] classification) and chromosome 7 abnormalities in the Spanish MDS Registry were evaluated retrospectively. Four karyotypic groups were identified: isolated del(7q) (n = 29), isolated monosomy 7 (n = 27), del(7q) with additional abnormalities (n = 24), and monosomy 7 with additional abnormalities (n = 53).
  
  
  RESULTS
  Isolated del(7q) was more frequent in patients with less advanced MDS according to the WHO classification or the International Prognostic Scoring System. In addition, isolated del(7q) was associated with fewer blasts in bone marrow than other cytogenetics groups. Survival was significantly superior in patients with isolated del(7) than in those with isolated monosomy 7, del(7q) with additional abnormalities, or monosomy 7 with additional abnormalities. On multivariate analysis, age, the percentage of blasts in bone marrow, and other chromosome 7 abnormalities apart from isolated del(7q) were identified as independent risk factors for survival.
  
  
  CONCLUSIONS
  The current results demonstrated that patients who had MDS with isolated del(7q) had some distinct clinical-pathologic characteristics as well as better survival than patients who had MDS with isolated monosomy 7.
authors: Department of Hematology, Salamanca University Hospital, Salamanca, Spain.
authors: Iris
authors: I
authors: Cordoba
authors: José R
authors: JR
authors: González-Porras
authors: Benet
authors: B
authors: Nomdedeu
authors: Elisa
authors: E
authors: Luño
authors: Raquel
authors: R
authors: de Paz
authors: Esperanza
authors: E
authors: Such
authors: Mar
authors: M
authors: Tormo
authors: Teresa
authors: T
authors: Vallespi
authors: Rosa
authors: R
authors: Collado
authors: Blanca
authors: B
authors: Xicoy
authors: Rafael
authors: R
authors: Andreu
authors: Juan A
authors: JA
authors: Muñoz
authors: Francesc
authors: F
authors: Solé
authors: Jose
authors: J
authors: Cervera
authors: Consuelo
authors: C
authors: del Cañizo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000401:mortality; D011379:Prognosis; D017384:Sequence Deletion