title: Spontaneous regression of a congenital melanocytic nevus.
abstract: Congenital melanocytic nevus (CMN) may rarely regress which may also be associated with a halo or vitiligo. We describe a 10-year-old girl who presented with CMN on the left leg since birth, which recently started to regress spontaneously with associated depigmentation in the lesion and at a distant site. Dermoscopy performed at different sites of the regressing lesion demonstrated loss of epidermal pigments first followed by loss of dermal pigments. Histopathology and Masson-Fontana stain demonstrated lymphocytic infiltration and loss of pigment production in the regressing area. Immunohistochemistry staining (S100 and HMB-45), however, showed that nevus cells were present in the regressing areas.
authors: Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
authors: Amiya Kumar
authors: AK
authors: Nath
authors: Devinder Mohan
authors: DM
authors: Thappa
authors: Nachiappa Ganesh
authors: NG
authors: Rajesh
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis* / Q000276:immunology; D009508:Nevus, Pigmented / Q000175:diagnosis* / Q000276:immunology; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000276:immunology