title: Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats.
abstract: BACKGROUND
  Recent studies have reported the preventive effects of probiotics on obesity. Among commensal bacteria, bifidobacteria is one of the most numerous probiotics in the mammalian gut and are a type of lactic acid bacteria. The aim of this study was to assess the antiobesity and lipid-lowering effects of Bifidobacterium spp. isolated from healthy Korean on high fat diet-induced obese rats.
  
  
  METHODS
  Thirty-six male Sprague-Dawley rats were divided into three groups as follows: (1) SD group, fed standard diet; (2) HFD group, fed high fat diet; and (3) HFD-LAB group, fed high fat diet supplemented with LAB supplement (B. pseudocatenulatum SPM 1204, B. longum SPM 1205, and B. longum SPM 1207; 108 ~ 109 CFU). After 7 weeks, the body, organ, and fat weights, food intake, blood serum levels, fecal LAB counts, and harmful enzyme activities were measured.
  
  
  RESULTS
  Administration of LAB reduced body and fat weights, blood serum levels (TC, HDL-C, LDL-C, triglyceride, glucose, leptin, AST, ALT, and lipase levels), and harmful enzyme activities (β-glucosidase, β-glucuronidase, and tryptophanase), and significantly increased fecal LAB counts.
  
  
  CONCLUSIONS
  These data suggest that Bifidobacterium spp. used in this study may have beneficial antiobesity effects.
authors: College of Pharmacy, Sahmyook University, Seoul, Republic of Korea.
authors: Hyang Mi
authors: HM
authors: An
authors: Shin Young
authors: SY
authors: Park
authors: Do Kyung
authors: DK
authors: Lee
authors: Jung Rae
authors: JR
authors: Kim
authors: Min Kyeong
authors: MK
authors: Cha
authors: Si Won
authors: SW
authors: Lee
authors: Hyung Taeck
authors: HT
authors: Lim
authors: Kyung Jae
authors: KJ
authors: Kim
authors: Nam Joo
authors: NJ
authors: Ha
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001644:Bifidobacterium; D001786:Blood Glucose; D004041:Dietary Fats; D005243:Feces / Q000201:enzymology / Q000382:microbiology; D005966:Glucuronidase / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D020738:Leptin / Q000097:blood; D008049:Lipase / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D019936:Probiotics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014368:Tryptophanase / Q000378:metabolism; D014510:Urease / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects; D000516:alpha-Amylases / Q000097:blood; D001617:beta-Glucosidase / Q000378:metabolism
chemical_list: D019440:Anti-Obesity Agents; D001786:Blood Glucose; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D020738:Leptin; D008055:Lipids; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008049:Lipase; D000516:alpha-Amylases; D001617:beta-Glucosidase; D005966:Glucuronidase; D014510:Urease; D014368:Tryptophanase