title: Nuclear Editing of mRNA 3'-UTRs.
abstract: Hundreds of human genes express mRNAs that contain inverted repeat sequences within their 3'-UTRs. When expressed, these sequences can be promiscuously edited by ADAR enzymes, leading to the retention of mRNAs in nuclear paraspeckles. Here we discuss how this retention system can be used to regulate gene expression.
authors: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, 200031 Shanghai, China. linglingchen@sibcb.ac.cn
authors: Ling-Ling
authors: LL
authors: Chen
authors: Gordon G
authors: GG
authors: Carmichael
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D002467:Cell Nucleus / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D017393:RNA Editing
chemical_list: D020413:3' Untranslated Regions