title: Correlation between HIV disease and lipid metabolism in antiretroviral-naïve HIV-infected patients in Japan.
abstract: Antiretroviral therapy alters lipid metabolism in HIV-infected patients. However, interpreting the impact of HIV infection on lipid metabolism is difficult because of various associated factors, including antiretroviral drugs and demographic characteristics. A few studies have associated HIV infection with lipid metabolism in antiretroviral-naïve HIV-infected patients. Because there were no data in this regard from Japan, the present study examined the impact of HIV infection, as well as demographic and clinical features, on lipid metabolism in antiretroviral-naïve HIV-infected patients in Japan. We performed a cross-sectional study to examine the impact of HIV disease, demographic and clinical characteristics on lipid metabolism among 168 HIV-infected Japanese men who were antiretroviral naïve and who did not have hemophilia, including patients who took medication for dyslipidemia. The mean age of the patients was 45.7 years; 0.6% of the patients took medication to dyslipidemia. The mean CD4 lymphocyte count was 289/μL, the mean baseline log10 HIV viral load was 4.2 HIV-1 RNA copies/mL, and 22% of the patients had a history of AIDS-defining events. A higher HDL-C concentration was associated with a higher CD4 lymphocyte count (p = 0.043). Also, a higher LDL-C concentration was associated with a higher CD4 lymphocyte count (p = 0.003). Infection with HIV was associated with dyslipidemia in antiretroviral-naïve patients. More advanced HIV disease was associated with less favorable lipid homeostatic profiles. These results are similar to findings from other countries.
authors: Department of General Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
authors: Fukuko
authors: F
authors: Oka
authors: Toshio
authors: T
authors: Naito
authors: Miki
authors: M
authors: Oike
authors: Rino
authors: R
authors: Imai
authors: Mizue
authors: M
authors: Saita
authors: Akihiro
authors: A
authors: Inui
authors: Kazunori
authors: K
authors: Mitsuhashi
authors: Hiroshi
authors: H
authors: Isonuma
authors: Takuro
authors: T
authors: Shimbo
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism / Q000821:virology; D000328:Adult; D018791:CD4 Lymphocyte Count; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007564:Japan; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D012189:Retrospective Studies; D019562:Viral Load
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D012367:RNA, Viral; D002784:Cholesterol