title: Mutations in EGFR signal pathway in correlation with response to treatment of head and neck cancers.
abstract: The prognostic and predictive value of the epidermal growth factor receptor (EGFR) expression and some genetic alterations in an EGFR signal pathway, such as the EGFR amplification, the EGFR activating tyrosine kinase domain mutations or the k-ras gene mutation were investigated in our study. The aim of the research was to evaluate the occurrence of the above-mentioned biomarkers in correlation with a therapeutic response and survival in patients with locoregionally advanced spinocellular head and neck cancers.
  
  
  BACKGROUND
  Head and neck cancer, EGFR, predictive marker, k-ras, EGFR amplification, EGFR tyrosine kinase domain mutation.
authors: Clinic of Otorhinolaryngology and Head and Neck Surgery, Masaryk University and St. Anne's Faculty Hospital in Brno, Czech Republic. janeuwi@gmail.com
authors: J
authors: J
authors: Neuwirthová
authors: S
authors: S
authors: Pavel
authors: J
authors: J
authors: Rottenberg
authors: R
authors: R
authors: Kostřica
authors: M
authors: M
authors: Zdeněk
authors: M
authors: M
authors: Hajdúch
authors: J
authors: J
authors: Drábek
authors: J
authors: J
authors: Srovnal
authors: J
authors: J
authors: Berkovcová
mesh_terms: D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality; D006801:Humans; D009154:Mutation; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D066246:ErbB Receptors