title: Influence of radiofrequency ablation of lung cancer on pulmonary function.
abstract: OBJECTIVE
  The purpose of this study was to evaluate altered pulmonary function retrospectively after RFA.
  
  
  METHODS
  This retrospective study comprised 41 ablation sessions for 39 patients (22 men and 17 women; mean age, 64.8 years). Vital capacity (VC) and forced expiratory volume in 1 s (FEV(1)) at 1 and 3 months after RFA were compared with the baseline (i.e., values before RFA). To evaluate the factors that influenced impaired pulmonary function, univariate analysis was performed by using multiple variables. If two or more variables were indicated as statistically significant by univariate analysis, these variables were subjected to multivariate analysis to identify independent factors.
  
  
  RESULTS
  The mean VC and FEV(1) before RFA and 1 and 3 months after RFA were 3.04 and 2.24 l, 2.79 and 2.11 l, and 2.85 and 2.13 l, respectively. The values at 1 and 3 months were significantly lower than the baseline. Severe pleuritis after RFA was identified as the independent factor influencing impaired VC at 1 month (P = 0.003). For impaired FEV(1) at 1 month, only severe pleuritis (P = 0.01) was statistically significant by univariate analysis. At 3 months, severe pleuritis (VC, P = 0.019; FEV(1), P = 0.003) and an ablated parenchymal volume ≥20 cm(3) (VC, P = 0.047; FEV(1), P = 0.038) were independent factors for impaired VC and FEV(1).
  
  
  CONCLUSIONS
  Pulmonary function decreased after RFA. RFA-induced severe pleuritis and ablation of a large volume of marginal parenchyma were associated with impaired pulmonary function.
authors: Department of Radiology, Okayama University Medical School, Japan. tdakihiro@gmail.com
authors: Akihiro
authors: A
authors: Tada
authors: Takao
authors: T
authors: Hiraki
authors: Toshihiro
authors: T
authors: Iguchi
authors: Hideo
authors: H
authors: Gobara
authors: Hidefumi
authors: H
authors: Mimura
authors: Shinichi
authors: S
authors: Toyooka
authors: Katsuyuki
authors: K
authors: Kiura
authors: Toshihide
authors: T
authors: Tsuda
authors: Toshiharu
authors: T
authors: Mitsuhashi
authors: Susumu
authors: S
authors: Kanazawa
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D016014:Linear Models; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome