title: Whole-body vibration training elevates creatine kinase levels in sedentary subjects.
abstract: BACKGROUND
  Whole body vibration (WBV) is an increasingly popular modality of muscle training, especially in sedentary subjects. We hypothesised that the vigorous muscle contractions elicited by WBV can cause muscle damage expressed as an elevation in muscle enzymes.
  
  
  METHODS
  Twenty inactive subjects, ten male and ten female, aged 22.7 ± 2.6, BMI 22.4 ± 2.1 were included based on the absence of regular physical activity as defined by international guidelines, and no history of recent trauma, musculoskeletal pathology, implanted prosthetics, cardiovascular disease or drug intake. The intervention consisted of one bout of high intensity WBV corresponding to a typical training session, involving all the major muscle groups. Plasma levels of muscle enzymes prior to and at 24, 48 and 96 hours post exercise (creatine kinase - CK, MB fraction, troponin I, aminotransferases and lactate dehydrogenase) were measured. In addition, blood lactate was assayed immediately after exercise. Delayed onset muscle soreness (DOMS) was evaluated using a visual analogical scale.
  
  
  RESULTS
  Five participants (25%) showed a significant increase in post exercise CK levels (> double of baseline). Maximal value was 3520 U/l. No change was observed in CK-MB or troponin I. Lactate increased to 10.0 ± 2.4 in men and 6.9 ± 2.4 in women. All participants had some degrees of DOMS, without correlation to enzymatic changes.
  
  
  CONCLUSIONS
  WBV can provoke high CK elevation in healthy, medication-free inactive subjects. Such an elevation is transient and harmless, but could be wrongly attributed to drug induced myopathy, as in patients treated with statins. Practitioners should bear this in mind before discontinuing a potential life saving drug.
authors: Sports Medicine Unit, CHUV, Pierre Decker 4, CH-1011 Lausanne, Switzerland. boris.gojanovic@chuv.ch
authors: Boris
authors: B
authors: Gojanovic
authors: Francois
authors: F
authors: Feihl
authors: Lucas
authors: L
authors: Liaudet
authors: Gérald
authors: G
authors: Gremion
authors: Bernard
authors: B
authors: Waeber
mesh_terms: D000328:Adult; D019540:Area Under Curve; D003402:Creatine Kinase / Q000097:blood*; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000201:enzymology*; D010806:Physical Education and Training / Q000379:methods*; D057185:Sedentary Behavior; D013997:Time Factors; D014732:Vibration / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D019344:Lactic Acid; D003402:Creatine Kinase