title: Non-Edg family LPA receptors: the cutting edge of LPA research.
abstract: Lysophosphatidic acid (LPA) is a bioactive lipid mediator with diverse physiological and pathological actions on many types of cells. Originally, LPA was thought to elicit its biological functions through three subtypes of endothelial differentiation gene (Edg) family G protein-coupled receptors (LPA1, LPA2 and LPA3) until our group identified a fourth subtype, LPA4. The discovery of this receptor, which is structurally distinct from the Edg family LPA receptors, led to the identification of two additional LPA receptors, LPA5 and LPA6, homologous to LPA4. These 'non-Edg family' LPA receptors now provide a new framework for understanding the diverse functions of LPA, including vascular development, platelet activation and hair growth. In this review, we summarize the identification, intracellular signalling and biological functions of this novel cluster of LPA receptors.
authors: Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033.
authors: Keisuke
authors: K
authors: Yanagida
authors: Satoshi
authors: S
authors: Ishii
mesh_terms: D000818:Animals; D006197:Hair / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D051379:Mice; D010974:Platelet Aggregation / Q000235:genetics / Q000502:physiology; D049368:Receptors, Lysophosphatidic Acid / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D049349:Receptors, Lysosphingolipid / Q000235:genetics / Q000378:metabolism; D011983:Receptors, Purinergic / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D018048:Receptors, Purinergic P2; D015398:Signal Transduction
chemical_list: C082320:LPAR4 protein, human; C512992:LPAR5 protein, human; D008246:Lysophospholipids; D049368:Receptors, Lysophosphatidic Acid; D049349:Receptors, Lysosphingolipid; D011983:Receptors, Purinergic; D018048:Receptors, Purinergic P2; C032881:lysophosphatidic acid