title: Increased Mauthner cell activity and escaping behaviour in seabream fed long-chain PUFA.
abstract: There is limited information on the specific effects of long-chain PUFA (LCPUFA) on neuron development and functioning. Deficiency of those essential fatty acids impairs escape and avoidance behaviour in fish, where Mauthner cells (M-cells) play a particularly important role in initiating this response. Gilthead seabream larvae fed two different LCPUFA profiles were challenged with a sonorous stimulus. Feeding n-3 LCPUFA increased the content of these fatty acids in fish tissues and caused a higher number of larvae to react to the stimulus with a faster burst swimming speed response. This faster startle response in fish fed n-3 LCPUFA was also associated with an increased immune-positive neural response, particularly in M-cells, denoting a higher production of acetylcholine. The present study shows the first evidence of the effect of n-3 LCPUFA on the functioning of particular neurons in fish, the M-cells and the behaviour response that they modulate to escape from a sound stimulus.
authors: Grupo de Investigación en Acuicultura, Universidad de Las Palmas de Gran Canaria, Instituto Canario de Ciencias Marinas, PO 56, 35200 Telde, Las Palmas, Canary Islands, Spain. tibi.benitez.santana@gmail.com
authors: Tibiábin
authors: T
authors: Benítez-Santana
authors: Eduardo
authors: E
authors: Juárez-Carrillo
authors: Mónica Beatriz
authors: MB
authors: Betancor
authors: Silvia
authors: S
authors: Torrecillas
authors: María José
authors: MJ
authors: Caballero
authors: María Soledad
authors: MS
authors: Izquierdo
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D059329:Cholinergic Neurons / Q000166:cytology / Q000502:physiology; D003677:Deficiency Diseases / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control / Q000662:veterinary; D004924:Escape Reaction; D005228:Fatty Acids, Essential / Q000008:administration & dosage / Q000172:deficiency / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D005393:Fish Diseases / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use; D029941:Fish Proteins / Q000378:metabolism; D020540:Metencephalon / Q000166:cytology / Q000254:growth & development / Q000502:physiology* / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000254:growth & development / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D011897:Random Allocation; D013216:Reflex, Startle; D021541:Sea Bream / Q000254:growth & development / Q000502:physiology*; D013024:Soybean Oil / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D005228:Fatty Acids, Essential; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D029941:Fish Proteins; D009419:Nerve Tissue Proteins; D013024:Soybean Oil; D002795:Choline O-Acetyltransferase; D000109:Acetylcholine