title: Oral ulcers and necrotizing gingivitis in relation to HIV-associated neutropenia: a review and an illustrative case.
abstract: An unusual case of necrotizing gingivitis and neutropenic oral ulcers in an HIV-seropositive patient is presented. In spite of a very low CD4(+) T cell count and severe neutropenia, the necrotizing gingivitis responded favorably to standard periodontal treatment, and the oral ulcers healed after administration of granulocyte colony-stimulating factor (G-CSF). Nonspecific oral ulcers in HIV-seropositive subjects with neutropenia should be regarded as neutropenic ulcers. The term nonspecific ulcers should be restricted to those ulcers with nonspecific histopathological features in patients without neutropenia or a nutritional deficiency such as iron, folic acid, and vitamin B.
authors: Department of Periodontology and Oral Medicine, University of Limpopo, Pretoria, South Africa. lfeller@ul.ac.za
authors: Liviu
authors: L
authors: Feller
authors: Razia A G
authors: RA
authors: Khammissa
authors: Neil H
authors: NH
authors: Wood
authors: Robin
authors: R
authors: Meyerov
authors: Liron
authors: L
authors: Pantanowitz
authors: Johan
authors: J
authors: Lemmer
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000209:etiology; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D003773:Dental Plaque / Q000517:prevention & control; D012534:Dental Scaling; D005892:Gingivitis, Necrotizing Ulcerative / Q000188:drug therapy* / Q000209:etiology* / Q000821:virology; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use; D009503:Neutropenia / Q000150:complications / Q000821:virology*; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D009067:Mouthwashes