title: Septins at the annulus of mammalian sperm.
abstract: The annulus is an electron-dense ring structure connecting the midpiece and the principal piece of the mammalian sperm flagellum. Proteins from the septin family have been shown to localize to the annulus. A septin complex is assembled early in spermiogenesis with the cochaperone DNAJB13 and, in mature sperm, associates with Testis Anion Transporter 1; SLC26A8 (Tat1), a transmembrane protein of the SLC26 family. Studies in mice have shown that the annulus acts as a barrier to protein diffusion and controls correct organization of the midpiece. Consistent with these findings, absence of the annulus is associated with flagellum differentiation defects and asthenozoospermia in humans.
authors: INSERM, U1016, Institut Cochin, Paris, France. aminata.toure@inserm.fr
authors: Aminata
authors: A
authors: Toure
authors: Baptiste
authors: B
authors: Rode
authors: Gary R
authors: GR
authors: Hunnicutt
authors: Denise
authors: D
authors: Escalier
authors: Gérard
authors: G
authors: Gacon
mesh_terms: D000818:Animals; D027321:Anion Transport Proteins / Q000378:metabolism; D017920:Antiporters / Q000378:metabolism; D051017:Apoptosis Regulatory Proteins; D053627:Asthenozoospermia / Q000378:metabolism / Q000503:physiopathology; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D051379:Mice; D008954:Models, Biological; D018832:Molecular Chaperones; D011485:Protein Binding; D013082:Sperm Tail / Q000378:metabolism* / Q000502:physiology; D013094:Spermatozoa / Q000378:metabolism* / Q000502:physiology; D000076988:Sulfate Transporters
chemical_list: D027321:Anion Transport Proteins; D017920:Antiporters; D051017:Apoptosis Regulatory Proteins; C477075:DNAJB13 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; C455627:SLC26A8 protein, human; D000076988:Sulfate Transporters