title: Encapsulation of naproxen in lipid-based matrix microspheres: characterization and release kinetics.
abstract: The objective of this study was to microencapsulate the anti-inflammatory drug (naproxen) to provide controlled release and minimizing or eliminating local side effect by avoiding the drug release in the upper gastrointestinal track. Naproxen was microencapsulated with lipid-like carnauba wax, hydrogenated castor oil using modified melt dispersion (modified congealable disperse phase encapsulation) technique. Effect of various formulation and process variables such as drug-lipid ratio, concentration of modifier, concentration of dispersant, stirring speed, stirring time, temperature of external phase, on evaluatory parameters such as size, entrapment efficiency, and in vitro release of naproxen were studied. The microspheres were characterized for particle size, scanning electron microscopy (SEM), FT-IR spectroscopy, drug entrapment efficiency, in vitro release studies, for in vitro release kinetics. The shape of microspheres was found to be spherical by SEM. The drug entrapment efficiency of various batches of microspheres was found to be ranging from 60 to 90 %w/w. In vitro drug release studies were carried out up to 24 h in pH 7.4 phosphate buffer showing 50-65% drug release. In vitro drug release from all the batches showed better fitting with the Korsmeyer-Peppas model, indicating the possible mechanism of drug release to be by diffusion and erosion of the lipid matrix.
authors: S.K.B. College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India.
authors: P K
authors: PK
authors: Bhoyar
authors: D O
authors: DO
authors: Morani
authors: D M
authors: DM
authors: Biyani
authors: M J
authors: MJ
authors: Umekar
authors: J G
authors: JG
authors: Mahure
authors: Y M
authors: YM
authors: Amgaonkar