title: Pathophysiology, classifications, and natural history of Perthes disease.
abstract: Since the original reports of Legg-Calvé-Perthes disease (LCPD), much research effort has been undertaken to improve understanding of this idiopathic hip disorder. This article focuses on the current knowledge of the pathophysiology, classifications, and natural history of LCPD. Although the cause of LCPD remains largely unknown, some insight has been gained on its pathophysiology through experimental studies using animal models of ischemic necrosis. The few available clinical studies on the natural history of LCPD suggest that femoral head deformity is well tolerated in short and intermediate terms, but 50% of patients develop disabling arthritis in the sixth decade of life.
authors: Center for Excellence in Hip Disorders, Research Department, Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA. harry.kim@tsrh.org
authors: Harry K W
authors: HK
authors: Kim
authors: John A
authors: JA
authors: Herring
mesh_terms: D000818:Animals; D018450:Disease Progression; D005270:Femur Head / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D007873:Legg-Calve-Perthes Disease / Q000145:classification / Q000209:etiology / Q000503:physiopathology; D011379:Prognosis; D012039:Regional Blood Flow; D012720:Severity of Illness Index