title: Visfatin is secreted into the breast milk and is correlated with weight changes of the infant after the birth.
abstract: BACKGROUND
  Visfatin is a recently identified adipokine with numerous metabolic and immunoregulatory properties that has been implicated in the regulation of the white adipose tissue (WAT) and significant changes in visfatin levels were reported during pregnancy. The aim of the study was to investigate dynamics of visfatin levels in maternal serum and human breast milk during a 180-d period after the delivery.
  
  
  METHODS
  : Breast milk and venous blood samples were obtained from 24 healthy lactating women with uncomplicated, physiological pregnancy and appropriate-for-gestational age neonates and serum-milk sample duos were collected at the time of birth, at the 1-3, 12-14, 28-30, 88-90 and 178-180 postpartum.
  
  
  RESULTS
  Our study demonstrates that (1) visfatin is abundantly secreted into breast milk in humans, reaching approx. 100× higher concentrations compared to maternal serum; (2) visfatin concentrations in maternal serum show significant variations after the delivery and (3) visfatin concentration in colostrum could be used for prediction of the subsequent weight development (less/more severe weight loss during first 3 days after the birth) of the infant.
  
  
  CONCLUSIONS
  Our data suggest that visfatin could play an important role in regulation of adiposity of the infant after the birth.
authors: Department of Pathological Physiology, Masaryk University, Brno, Czech Republic. jbienert@med.muni.cz
authors: Julie
authors: J
authors: Bienertová-Vašků
authors: P
authors: P
authors: Bienert
authors: F
authors: F
authors: Zlámal
authors: J
authors: J
authors: Tomandl
authors: M
authors: M
authors: Tomandlová
authors: Z
authors: Z
authors: Dostálová
authors: A
authors: A
authors: Vašků
mesh_terms: D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism*; D000328:Adult; D000704:Analysis of Variance; D001724:Birth Weight / Q000187:drug effects / Q000502:physiology*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008895:Milk, Human / Q000187:drug effects / Q000378:metabolism*; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism*; D011247:Pregnancy; D011795:Surveys and Questionnaires; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology*
chemical_list: D054409:Nicotinamide Phosphoribosyltransferase