title: Decorin gene expression and its regulation in human keratinocytes.
abstract: In various cell types, including cancer cells, decorin is involved in regulation of cell attachment, migration and proliferation. In skin, decorin is seen in dermis, but not in keratinocytes. We show that decorin gene (DCN) is expressed in the cultured keratinocytes, and the protein is found in the cytoplasm of differentiating keratinocytes and in suprabasal layers of human epidermis. RT-PCR experiments showed that DCN expression is regulated by pro-inflammatory and proliferative cytokines. Our data suggest that decorin should play a significant role in keratinocyte terminal differentiation, cutaneous homeostasis and dermatological diseases.
authors: Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del IPN, Apdo. Postal 14-740, México DF 07000, Mexico.
authors: Cristina
authors: C
authors: Velez-DelValle
authors: Meytha
authors: M
authors: Marsch-Moreno
authors: Federico
authors: F
authors: Castro-Muñozledo
authors: Walid
authors: W
authors: Kuri-Harcuch
mesh_terms: D002478:Cells, Cultured; D058575:Decorin / Q000235:genetics* / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism* / Q000473:pathology; D011565:Psoriasis / Q000378:metabolism / Q000473:pathology
chemical_list: C546878:DCN protein, human; D058575:Decorin