title: Postoperative conjunctival inflammation after pterygium surgery with amniotic membrane transplantation versus conjunctival autograft.
abstract: OBJECTIVE
  To compare the postoperative conjunctival inflammation around the surgical site after pterygium surgery using either amniotic membrane transplantation (AMT) or free conjunctival autograft.
  
  
  METHODS
  Prospective, randomized, interventional study.
  
  
  METHODS
  Forty-two eyes of 42 patients with primary pterygium underwent surgical excision followed by removal of subconjunctival fibrovascular tissue and intraoperative application of 0.02% mitomycin C. Then, the patients were randomized to receive either AMT (21 eyes) or free conjunctival autograft (21 eyes), with sutures used in both groups. Main outcome measures included presence of host conjunctival inflammation around the surgical site at 1 month after surgery and also recurrence of pterygium.
  
  
  RESULTS
  Twelve-month follow-up was completed in 39 eyes of 39 patients (19 in the AMT group and 20 in the conjunctival autograft group). At 1 month after surgery, different grades of host conjunctival inflammation were present in 16 eyes (84.2%) in the AMT group and in 3 eyes (15%) in the conjunctival autograft group (P = .02). Subconjunctival injection of triamcinolone was performed in eyes with moderate or severe inflammation, which included 12 eyes (63.1%) in the AMT group and 2 eyes (10%) in the conjunctival autograft group (P < .001). Conjunctival recurrence of pterygium was seen in 2 eyes (10.5%) in the AMT group and in 2 eyes (10%) in the conjunctival autograft group (P = .92). After surgery, pyogenic granuloma developed in 3 eyes (15.8%) in the AMT group and in 1 eye (5%) in the conjunctival autograft group (P = .31).
  
  
  CONCLUSIONS
  After pterygium surgery, conjunctival inflammation was significantly more common with AMT than with conjunctival autograft. However, with control of such inflammation and intraoperative application of mitomycin C, similar final outcomes were achieved with both techniques.
authors: Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran. Akheirkh@yahoo.com
authors: Ahmad
authors: A
authors: Kheirkhah
authors: Rahman
authors: R
authors: Nazari
authors: Mojgan
authors: M
authors: Nikdel
authors: Hamed
authors: H
authors: Ghassemi
authors: Hassan
authors: H
authors: Hashemi
authors: Mahmoud Jabbarvand
authors: MJ
authors: Behrouz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000477:Alkylating Agents / Q000008:administration & dosage; D000650:Amnion / Q000637:transplantation*; D001684:Biological Dressings; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000637:transplantation*; D003231:Conjunctivitis / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D011183:Postoperative Complications; D011446:Prospective Studies; D011625:Pterygium / Q000503:physiopathology / Q000601:surgery*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin