title: MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia.
abstract: Mutations and/or overexpression of c-Kit proto-oncogene frequently occur in subsets of acute myeloid leukemia (AML) and contribute to abnormal cell proliferation and poor outcomes. We showed that c-Kit expression was subject to post-transcriptional regulation by microRNA (miRNA)-193b. Notably, miR-193b was significantly down-regulated in the examined AML cells and its levels were inversely correlated with c-Kit levels. Restoration of miR-193b expression in AML cells resulted in distinctly reduced c-Kit expression and inhibited cell growth. These data reveal a role for miR-193b dysregulation in myeloid leukemogenesis and the therapeutic promise of regulating miR-193b expression for c-Kit-positive AML.
authors: Department of Hematology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors: Xiao-ning
authors: XN
authors: Gao
authors: Ji
authors: J
authors: Lin
authors: Li
authors: L
authors: Gao
authors: Yong-hui
authors: YH
authors: Li
authors: Li-li
authors: LL
authors: Wang
authors: Li
authors: L
authors: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049109:Cell Proliferation; D002478:Cells, Cultured; D015536:Down-Regulation / Q000235:genetics; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D008875:Middle Aged; D000090063:Proto-Oncogene Mas; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: C000715470:MAS1 protein, human; C546818:MIRN193 microRNA, human; D035683:MicroRNAs; D000090063:Proto-Oncogene Mas; D019009:Proto-Oncogene Proteins c-kit