title: Trimethoprim-sulphamethoxazole-associated rhabdomyolysis in an HIV-infected patient.
abstract: We describe a case of rhabdomyolysis associated with trimethoprim-sulphamethoxazole (TMP-SMZ) in a HIV-infected patient. A 33-year-old African American man with newly diagnosed AIDS initially presented with persistent, high-grade fevers suspected to be TMP-SMZ-related drug fever. The antibiotic was discontinued while in the hospital, but the patient was restarted on TMP-SMZ following discharge. Two days later, he returned to the hospital with severe muscle pain, acute renal failure and a significantly elevated creatine phosphokinase consistent with rhabdomyolysis. The patient gradually improved following discontinuation of TMP-SMZ.
authors: The University Hospital, Newark, NJ 07101-1709, USA. jensp@umdnj.edu
authors: S P
authors: SP
authors: Jen
authors: R
authors: R
authors: Sharma
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage* / Q000009:adverse effects*; D028761:Withholding Treatment
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination