title: Association between cytokine gene polymorphisms and cervical cancer in a Chinese population.
abstract: OBJECTIVE
  It has been hypothesized that inherited cytokine gene polymorphisms could influence susceptibility to cervical cancer. This study evaluated the association between tumour necrosis factor-alpha (TNF-α)-308, transforming growth factor-beta 1 (TGF-β1), interferon-gamma (IFN-γ)+874 and interleukin-10 (IL-10)-1082 gene polymorphisms and cervical cancer risk.
  
  
  METHODS
  The study population included 186 histopathologically confirmed cases of cervical cancer and 200 healthy controls. TNF-α, TGF-β, IL-10 and IFN-γ gene polymorphisms were genotyped by polymerase chain reaction with sequence-specific primers.
  
  
  RESULTS
  The IFN-γ+874A/A genotype was associated with high risk for the development of cervical cancer [odds ratio (OR) 2.22, p=0.012], and the A allele was associated with a 1.47-fold increased risk of cervical cancer (p=0.009). In contrast, no significant difference was found in the frequencies of TNF-α-308G/A, TGF-β1 codons 10 and 25 C/C-G/G and IL-10-1082G/A gene polymorphisms between patients with cervical cancer and healthy controls.
  
  
  CONCLUSIONS
  Homozygous IFN-γ+874A/T polymorphisms may be associated with increased risk for the development of cervical cancer.
authors: Centre for Cancer Research, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
authors: Qian
authors: Q
authors: Wang
authors: Chenhua
authors: C
authors: Zhang
authors: Shah
authors: S
authors: Walayat
authors: Hong Wei
authors: HW
authors: Chen
authors: Yili
authors: Y
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D016207:Cytokines / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D016212:Transforming Growth Factor beta / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D016207:Cytokines; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma