title: Effect of a Semisolid Formulation of Linum usitatissimum L. (Linseed) Oil on the Repair of Skin Wounds.
abstract: The purpose of this study was to investigate the effects of a semisolid formulation of linseed oil, SSFLO (1%, 5%, or 10%) or in natura linseed oil on skin wounds of rats. We used wound models, incisional and excisional, to evaluate, respectively, the contraction/reepithelialization of the wound and resistance to mechanical traction. The groups (n = 6) treated with SSFLO (1% or 5%) began the process of reepithelialization, to a significant extent (P < .05), on the sixth day, when compared to the petroleum jelly control group. On 14th day for the groups treated with SSFLO (1% or 5%), 100% reepithelialization was found, while in the petroleum jelly control group, this was only 33.33%. Our study showed that topical administration of SSFLO (1% or 5%) in excisional wounds allowed reepithelialization in 100% of treated animals. Therefore, a therapeutic potential of linseed oil, when used at low concentrations in the solid pharmaceutical formulations, is suggested for the process of dermal repair.
authors: Department of Physiology and Pharmacology, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil.
authors: Eryvelton
authors: E
authors: de Souza Franco
authors: Camilla Maria Ferreira
authors: CM
authors: de Aquino
authors: Paloma Lys
authors: PL
authors: de Medeiros
authors: Liriane Baratella
authors: LB
authors: Evêncio
authors: Alexandre José
authors: AJ
authors: da Silva Góes
authors: Maria Bernadete
authors: MB
authors: de Souza Maia