title: Phosphodiesterase type 5 (PDE5) in the adipocyte: a novel player in fat metabolism?
abstract: Phosphodiesterase type 5 (PDE5) is expressed in many tissues (e.g. heart, lung, pancreas, penis) and plays a specific role in hydrolyzing cyclic guanosine monophosphate (cGMP). In adipocytes, cGMP regulates crucial functions by activating cGMP-dependent protein kinase (PKG). Interestingly, PDE5 was recently identified in adipose tissue, although its role remains unclear. Its inhibition, however, was recently shown to affect adipose differentiation and aromatase function. This review summarizes evidence supporting a role for the PDE5-regulated cGMP/PKG system in adipose tissue and its effects on adipocyte function. A better elucidation of the role of PDE5 in the adipocyte could reveal new therapeutic strategies for fighting obesity and metabolic syndrome.
authors: Center for Clinical and Basic Research, Scientific Institute for Research, Hospitalization and Health Care (IRCCS) San Raffaele Pisana, Rome, Italy.
authors: Andrea
authors: A
authors: Armani
authors: Vincenzo
authors: V
authors: Marzolla
authors: Giuseppe M C
authors: GM
authors: Rosano
authors: Andrea
authors: A
authors: Fabbri
authors: Massimiliano
authors: M
authors: Caprio
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000201:enzymology*; D050156:Adipogenesis; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation; D006152:Cyclic GMP / Q000502:physiology; D017869:Cyclic GMP-Dependent Protein Kinases / Q000378:metabolism; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5 / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D007328:Insulin; D050356:Lipid Metabolism; D008066:Lipolysis; D009765:Obesity; D015398:Signal Transduction
chemical_list: D007328:Insulin; D017869:Cyclic GMP-Dependent Protein Kinases; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; D006152:Cyclic GMP