title: Incidence of bacteremic melioidosis in eastern and northeastern Thailand.
abstract: Burkholderia pseudomallei, the causative agent of melioidosis, is endemic in northeastern Thailand. Population-based disease burden estimates are lacking and limited data on melioidosis exist from other regions of the country. Using active, population-based surveillance, we measured the incidence of bacteremic melioidosis in the provinces of Sa Kaeo (eastern Thailand) and Nakhon Phanom (northeastern Thailand) during 2006-2008. The average annual incidence in Sa Kaeo and Nakhon Phanom per 100,000 persons was 4.9 (95% confidence interval [CI] = 3.9-6.1) and 14.9 (95% CI = 13.3-16.6). The respective population mortality rates were 1.9 (95% CI = 1.3-2.8) and 4.4 (95% CI = 3.6-5.3) per 100,000. The case-fatality proportion was 36% among those with known outcome. Our findings document a high incidence and case fatality proportion of bacteremic melioidosis in Thailand, including a region not traditionally considered highly endemic, and have potential implications for clinical management and health policy.
authors: International Emerging Infections Program (IEIP), Thailand Ministry of Public Health - U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand. saithipb@th.cdc.gov
authors: Saithip
authors: S
authors: Bhengsri
authors: Henry C
authors: HC
authors: Baggett
authors: Possawat
authors: P
authors: Jorakate
authors: Anek
authors: A
authors: Kaewpan
authors: Prabda
authors: P
authors: Prapasiri
authors: Sathapana
authors: S
authors: Naorat
authors: Somsak
authors: S
authors: Thamthitiwat
authors: Kittisak
authors: K
authors: Tanwisaid
authors: Somrak
authors: S
authors: Chantra
authors: Prasert
authors: P
authors: Salika
authors: Surang
authors: S
authors: Dejsirilert
authors: Leonard F
authors: LF
authors: Peruski
authors: Susan A
authors: SA
authors: Maloney
mesh_terms: D016470:Bacteremia / Q000453:epidemiology*; D019353:Endemic Diseases; D006801:Humans; D015994:Incidence; D008554:Melioidosis / Q000453:epidemiology*; D011159:Population Surveillance; D013785:Thailand / Q000453:epidemiology