title: In vitro antimicrobial activity of aminoreductone against the pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA).
abstract: In this study, antimicrobial activity of aminoreductone (AR), a product formed during the initial stage of the Maillard reaction, against methicillin-resistant Staphylococcus aureus (MRSA) was evaluated. The significant growth inhibition of all 51 MRSA isolates irrespective of drug susceptibility by AR was observed. The minimum inhibitory concentration (MIC) of AR ranged from 13 to 26 mM. The bactericidal activity of AR was evaluated by a killing assay with multiples of MIC, and it was recognized to depend on its dose. The combined effects of AR and antibiotics frequently used for the treatment of infections caused by Gram-positive and Gram-negative bacteria, such as amikacin (AN), ciprofloxacin, imipenem and levofloxacin, were examined. As a result, AR did not interfere with these antibiotic activities against 12 MRSA isolates selected and showed the advanced effect of growth inhibition in combination with antibiotics. Moreover, the inhibitory effects of AR were similar to those of AN, an antibiotic with known adverse effects, some serious. These findings show that AR is a naturally formed antimicrobial agent present in thermally processed foods with potential health benefits in medical practice.
authors: School of Biology and Food Technology, Hanoi University of Science and Technology, Hanoi, Vietnam.
authors: Vu Thu
authors: VT
authors: Trang
authors: Hiroaki
authors: H
authors: Takeuchi
authors: Hayato
authors: H
authors: Kudo
authors: Shinya
authors: S
authors: Katsuno
authors: Tomoko
authors: T
authors: Shimamura
authors: Takehiro
authors: T
authors: Kashiwagi
authors: Vu Hong
authors: VH
authors: Son
authors: Tetsuro
authors: T
authors: Sugiura
authors: Hiroyuki
authors: H
authors: Ukeda
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007661:Ketoses / Q000494:pharmacology*; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D015416:Maillard Reaction; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D007661:Ketoses; C568538:aminoreductone; D008239:Lysine