title: Single-nucleotide polymorphisms in the lysyl oxidase-like protein 4 and complement component 3 genes are associated with increased risk for endometriosis and endometriosis-associated infertility.
abstract: This study was conducted to assess genetic associations with endometriosis in a Puerto Rican population. Statistically significant differences in the allelic frequencies and genotype distribution of genetic variants in lysyl oxidase-like protein 4 (LOXL4) and complement component 3 (C3) were documented in patients with endometriosis-associated infertility versus controls, and in patients with endometriosis versus controls, respectively. In women who have the risk genotype at both single-nucleotide polymorphisms, the estimated risk for endometriosis nearly doubled.
authors: Department of Microbiology, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico 00716-2348, USA.
authors: Lynnette A
authors: LA
authors: Ruiz
authors: Julie
authors: J
authors: Dutil
authors: Abigail
authors: A
authors: Ruiz
authors: Jessica
authors: J
authors: Fourquet
authors: Sonia
authors: S
authors: Abac
authors: Joaquín
authors: J
authors: Laboy
authors: Idhaliz
authors: I
authors: Flores
mesh_terms: D000328:Adult; D000594:Amino Acid Oxidoreductases / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003176:Complement C3 / Q000235:genetics*; D004715:Endometriosis / Q000150:complications / Q000201:enzymology / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007247:Infertility, Female / Q000201:enzymology / Q000235:genetics* / Q000276:immunology; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D008249:Protein-Lysine 6-Oxidase; D011647:Puerto Rico; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C038245:C3 protein, human; D003176:Complement C3; D000594:Amino Acid Oxidoreductases; C445682:LOXL4 protein, human; D008249:Protein-Lysine 6-Oxidase