title: Subjective emotional experience at different stages of Parkinson's disease.
abstract: Subjective emotional experience is thought to rely on a large cortical-subcortical network including orbitofrontal and cingulate frontostriatal circuits together with the mesolimbic dopaminergic system that modulates their activity. Parkinson's disease (PD) provides a model for exploring this issue. By using an original emotion induction procedure, the present study examined to what extent subjective experience of emotion of PD patients at different stages of the disease was modulated by emotion in the same way as healthy individuals. A battery of film excerpts was used to elicit different emotional feelings (happiness, anger, fear, sadness, disgust, and neutral) in 15 newly diagnosed PD patients, 18 patients with advanced PD and 15 matched controls. The newly diagnosed patients were examined in two conditions: "on" and "off" dopaminergic medication. Participants reported the intensity of their emotional feelings on a scale consisting of 10 emotional categories. Results indicated that PD patients at different stages of the disease did not significantly differ from the controls in the self-reported emotional experience to the presented film excerpts. Moreover, analyses conducted within the newly diagnosed PD group (on-dopa vs. off-dopa conditions) indicated that the patients' emotional reactivity to the presented film excerpts was not significantly modulated by dopaminergic medication. These results thus question the possible role of dopaminergic pathways in subjective emotional experience, at least in this sample and in the context of emotion induction.
authors: Centre de Recherches sur la Cognition et l'Apprentissage, UMR CNRS 6234, Université de Poitiers, France. siobhan.vicente@univ-poitiers.fr
authors: Siobhan
authors: S
authors: Vicente
authors: Julie
authors: J
authors: Péron
authors: Isabelle
authors: I
authors: Biseul
authors: Sophie
authors: S
authors: Ory
authors: Pierre
authors: P
authors: Philippot
authors: Sophie
authors: S
authors: Drapier
authors: Dominique
authors: D
authors: Drapier
authors: Marc
authors: M
authors: Vérin
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000978:Antiparkinson Agents / Q000494:pharmacology / Q000627:therapeutic use; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009040:Motion Pictures; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D010775:Photic Stimulation / Q000379:methods
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa