title: Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship.
abstract: To develop more potent small molecules with enhanced free radical scavenger properties, a series of N-substituted isatin derivatives was synthesized, and the cytoprotective effect on the apoptosis of PC12 cells induced by H2O2 was screened. All these compounds were found to be active, and N-ethyl isatin was found with the most potent activity of 69.7% protective effect on PC12 cells. Structure-activity relationship analyses showed the bioactivity of N-alkyl isatins decline as the increasing of the chain of the alkyl group, furthermore odd-even effect was found in the activity, which is interesting for further investigation.
authors: Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China. tougao88@163.com.
authors: Gang
authors: G
authors: Chen
authors: Ye
authors: Y
authors: Wang
authors: Xiaojiang
authors: X
authors: Hao
authors: Shuzhen
authors: S
authors: Mu
authors: Qianyun
authors: Q
authors: Sun