title: A rapid and facile method for the general synthesis of 3-aryl substituted 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazines and their ring fused analogues.
abstract: We report a general and facile method that provides rapid entry into 3-aryl substituted 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazines and their ring fused analogues in one-pot under palladium-copper catalysis. The methodology utilises simple and easily available substrates of broad range. The applicability of this reaction for the synthesis of optically active products has been demonstrated. A plausible reaction mechanism has also been proposed.
authors: Chemistry Division, Indian Institute of Chemical Biology (CSIR), Kolkata, India. chinmay@iicb.res.in
authors: Chinmay
authors: C
authors: Chowdhury
authors: Sanjukta
authors: S
authors: Mukherjee
authors: Biswajit
authors: B
authors: Chakraborty
authors: Basudeb
authors: B
authors: Achari
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D010165:Palladium / Q000737:chemistry; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011719:Pyrazines; D014230:Triazoles; D010165:Palladium; D003300:Copper