title: Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy.
abstract: Families of 2-arylbenzotriazoles and 2-arylindazoles that show positive effects in screens predictive of endogenous utrophin upregulation have been identified. Synthesis and structure-activity relationships are described leading to compounds with attractive in vitro profiles.
authors: Summit plc., 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, United Kingdom.
authors: Olivier
authors: O
authors: De Moor
authors: Colin R
authors: CR
authors: Dorgan
authors: Peter D
authors: PD
authors: Johnson
authors: Adam G
authors: AG
authors: Lambert
authors: Cristina
authors: C
authors: Lecci
authors: Carole
authors: C
authors: Maillol
authors: Gary
authors: G
authors: Nugent
authors: Séverine D
authors: SD
authors: Poignant
authors: Paul D
authors: PD
authors: Price
authors: Richard J
authors: RJ
authors: Pye
authors: Richard
authors: R
authors: Storer
authors: Jonathon M
authors: JM
authors: Tinsley
authors: Richard
authors: R
authors: Vickers
authors: Renate van
authors: Rv
authors: Well
authors: Fraser J
authors: FJ
authors: Wilkes
authors: Francis X
authors: FX
authors: Wilson
authors: Stephen P
authors: SP
authors: Wren
authors: Graham M
authors: GM
authors: Wynne
mesh_terms: D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D006801:Humans; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D008862:Microsomes, Liver / Q000187:drug effects*; D015394:Molecular Structure; D020388:Muscular Dystrophy, Duchenne / Q000188:drug therapy; D012995:Solubility; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D007191:Indazoles; D014230:Triazoles; C012771:benzotriazole