title: A DNA vaccine against ERBB2 impairs chemical carcinogenesis in random-bred hamsters.
abstract: Vaccines against oncoantigens halt early neoplastic lesions in several cancer-prone, genetically engineered mouse models, whereas their ability to prevent chemical carcinogenesis has not been explored. This is a significant issue, as exposure to chemical mutagens is responsible for a substantial percentage of cancers worldwide. Here, we show that the archetypal oncoantigen ERBB2 is transiently overexpressed in Syrian hamsters during the early stages of 7,12-dimethylbenz[α]anthracene (DMBA)-induced oral carcinogenesis. Repeated DNA vaccinations against ERBB2 significantly reduce the number, size, and severity of oral lesions in a manner directly proportional to the anti-ERBB2 antibody response. These results support the prospects of vaccines as a fresh strategy in the management of individuals at risk for exposure to defined carcinogenic agents.
authors: Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. giovanni.berta@unito.it
authors: Giovanni N
authors: GN
authors: Berta
authors: Andrea E
authors: AE
authors: Sprio
authors: Manuela
authors: M
authors: Iezzi
authors: Michela
authors: M
authors: Spadaro
authors: Susanna
authors: S
authors: Cappia
authors: Paolina
authors: P
authors: Salamone
authors: Federica
authors: F
authors: Di Scipio
authors: Barbara
authors: B
authors: Mognetti
authors: Mauro
authors: M
authors: Papotti
authors: Piero
authors: P
authors: Musiani
authors: Guido
authors: G
authors: Forni
authors: Federica
authors: F
authors: Cavallo
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D015153:Blotting, Western; D002273:Carcinogens / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D006224:Cricetinae; D007124:Immunoenzyme Techniques; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D009361:Neoplasm Invasiveness; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D019444:Vaccines, DNA / Q000627:therapeutic use*
chemical_list: D015127:9,10-Dimethyl-1,2-benzanthracene; D000911:Antibodies, Monoclonal; D002273:Carcinogens; D018719:Erb-b2 Receptor Tyrosine Kinases; D019444:Vaccines, DNA