title: Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism.
abstract: A novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed.
authors: School of Chemical Engineering, Northwest University, Xi'an 710069, China.
authors: Xue-Quan
authors: XQ
authors: Li
authors: Hui-Yun
authors: HY
authors: Wen
authors: Hai-Qing
authors: HQ
authors: Dong
authors: Wei-Ming
authors: WM
authors: Xue
authors: Giovanni M
authors: GM
authors: Pauletti
authors: Xiao-Jun
authors: XJ
authors: Cai
authors: Wen-Juan
authors: WJ
authors: Xia
authors: Donglu
authors: D
authors: Shi
authors: Yong-Yong
authors: YY
authors: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000633:toxicity; D002166:Camptothecin / Q000737:chemistry* / Q000633:toxicity; D005978:Glutathione / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry*; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D008823:Micelles; D011355:Prodrugs; D011092:Polyethylene Glycols; D005978:Glutathione; D002166:Camptothecin