title: Oral health-related quality of life and depression/anxiety in long-term recurrence-free patients after treatment for advanced oral squamous cell cancer.
abstract: This report focuses on the association between oral health-related quality of life (OHRQoL) and depression/anxiety of a homogeneous group of cancer patients who were recurrence-free for 8 years after treatment for advanced oral squamous cell. Participants were 24 patients (mean age 55 years, 75% men) treated with neoadjuvant concurrent radiochemotherapy followed by surgery with a mean recurrence-free period of 95 months (from 39 to 164 months). The OHRQoL (OHIP) and the anxiety/depression (HADS) were assessed twice (1 year between t1 and t2). OHRQoL was impaired in this group (mean OHIP score 65 units). In cross-lagged correlation analysis, the correlation between OHRQoL to t1 and depression to t2 was significant and greater than the non-significant correlation for depression to t1 and OHRQoL to t2 indicating that OHRQoL predicts depression better than vice versa. However, the difference in the correlation coefficients was not significant (ZPF-test). The same was true for OHRQoL and anxiety. The OHRQoL measured with the OHIP was impaired in comparison to the normal population. In the limitations of the study design and bearing the small sample size in mind, the results give evidence that OHRQoL predicts psychological outcomes, namely depression and anxiety, better than vice versa.
authors: Department of Prosthodontics, University of Heidelberg, Heidelberg, Germany. alexander.hassel@med.uni-heidelberg.de
authors: Alexander J
authors: AJ
authors: Hassel
authors: Daniel
authors: D
authors: Danner
authors: Kolja
authors: K
authors: Freier
authors: Christof
authors: C
authors: Hofele
authors: Kirsten
authors: K
authors: Becker-Bikowski
authors: Michael
authors: M
authors: Engel
mesh_terms: D001007:Anxiety / Q000523:psychology*; D016025:Bone Transplantation / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000523:psychology* / Q000601:surgery; D059186:Chemoradiotherapy, Adjuvant; D003863:Depression / Q000523:psychology*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000523:psychology* / Q000601:surgery; D020360:Neoadjuvant Therapy; D009909:Oral Health; D011788:Quality of Life; D019651:Plastic Surgery Procedures / Q000379:methods; D013524:Surgical Flaps / Q000145:classification; D011795:Surveys and Questionnaires; D016896:Treatment Outcome