title: Impact of trandolapril therapy and its combination with a calcium channel blocker on plasma adiponectin levels in patients with type 2 diabetes and hypertension.
abstract: BACKGROUND
  Adiponectin is secreted from adipose tissue and exhibits a protective effect against cardiovascular disease; plasma adiponectin concentrations are decreased in type 2 diabetic and in hypertensive patients.
  
  
  OBJECTIVE
  The aim of this study was to compare the effect of trandolapril (T) and its fixed-dose combination with verapamil (FDTV) on adiponectin levels in hypertensive type 2 diabetic patients.
  
  
  METHODS
  A total of 40 type 2 diabetic patients with never-treated hypertension were randomly assigned to two groups. One group received FDTV 180 mg + T 2 mg, once a day; the other group received T 2 mg once a day, administered for 3 months in both groups. Adiponectin was measured by enzyme-linked immunosorbent assay (ELISA) at the beginning and end of the study. Patients were evaluated monthly for blood pressure, fasting serum glucose and adverse events. Statistical analysis was performed with analysis of variance (ANOVA).
  
  
  RESULTS
  All patients experienced a significant reduction of blood pressure. Both therapeutics regimens increased the levels of adiponectin, However, FDTV produces a higher increase in the levels of the hormone (8.15 ± 4.6 to 10.96 ± 5.6 µg/ml) when compared with the T treatment (7.64 ± 3.8 to 8.92 ± 4.4 µg/ml), p < 0.05. None of the patients suffered adverse events.
  
  
  CONCLUSIONS
  Our results show that the addition of FDTV to T produced a greater increase on adiponectin levels than trandolapril alone.
authors: Mexican Group for Basic and Clinical Research in Internal Medicine, A.C., Clinic Research Unit, Hospital General de Ticomán SS DF, Plan de San Luis S/N esq Bandera, C.P. 07330, México DF. clinhta@hotmail.com
authors: Alberto F
authors: AF
authors: Rubio-Guerra
authors: Hilda
authors: H
authors: Vargas-Robles
authors: German
authors: G
authors: Vargas-Ayala
authors: Leticia
authors: L
authors: Rodríguez-Lopez
authors: David
authors: D
authors: Castro-Serna
authors: Bruno A
authors: BA
authors: Escalante-Acosta
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004338:Drug Combinations; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D052242:Adiponectin; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004338:Drug Combinations; D007211:Indoles; C052035:trandolapril; D014700:Verapamil