title: On the elucidation of the mechanism of Vinca alkaloid fluorination in superacidic medium.
abstract: Detailed investigations on one of the key steps of the superacidic fluorination of Vinca alkaloids that is the origin of C20' activation are reported. While two different pathways can be envisioned for the emergence of the transient secondary carbocationic intermediate, isotopic labeling experiments unambiguously revealed the involvement of a 1,2-hydride shift mechanism.
authors: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191 Gif-sur-Yvette, France.
authors: Emerson
authors: E
authors: Giovanelli
authors: Sébastien
authors: S
authors: Leroux
authors: Lionel
authors: L
authors: Moisan
authors: Hélène
authors: H
authors: Carreyre
authors: Pierre
authors: P
authors: Thuéry
authors: David-Alexandre
authors: DA
authors: Buisson
authors: Abdelkrim
authors: A
authors: Meddour
authors: Jean-Marie
authors: JM
authors: Coustard
authors: Sébastien
authors: S
authors: Thibaudeau
authors: Bernard
authors: B
authors: Rousseau
authors: Marc
authors: M
authors: Nicolas
authors: Paul
authors: P
authors: Hellier
authors: Eric
authors: E
authors: Doris
mesh_terms: D000143:Acids / Q000737:chemistry; D019281:Dimerization; D054879:Halogenation; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D014748:Vinca Alkaloids / Q000737:chemistry*
chemical_list: D000143:Acids; D014748:Vinca Alkaloids