title: Lipid profiling of lipoproteins by electrospray ionization tandem mass spectrometry.
abstract: Lipoproteins are of fundamental importance for the lipid transport and cardiovascular disease. The function and metabolism of lipoproteins is intimately linked to the biophysical properties of their surface lipids. Although a number of disease associations were found for lipid species in plasma, only a few studies reported lipid profiles of lipoproteins. Here, we provide an overview of techniques for lipoprotein separation, methods for lipid species analysis based on electrospray ionization tandem mass spectrometry (ESI-MS/MS) as well as data from recent lipidomic studies on lipoprotein fractions. We also discuss the different analytical strategies and how lipid profiling can expand our understanding of the biology and structures of lipoproteins.
authors: University of Regensburg, Germany.
authors: Max
authors: M
authors: Scherer
authors: Alfred
authors: A
authors: Böttcher
authors: Gerhard
authors: G
authors: Liebisch
mesh_terms: D000818:Animals; D005591:Chemical Fractionation; D004194:Disease; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D008074:Lipoproteins