title: Detection of bone lesions by CT in POEMS syndrome.
abstract: OBJECTIVE
  To study the utility of CT for detection of small bone lesions in POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome. For patients with a solitary bone lesion, irradiation is a first-line treatment, whereas systemic chemotherapy is indicated for patients with multiple bone lesions. Therefore it is important to correctly identify the number of bone lesions.
  
  
  METHODS
  We studied the sensitivity of chest/abdomen/pelvic CT to detect bone lesions in 28 patients with POEMS syndrome. (99m)Tc-HMDP bone scintigraphy was performed in 14 patients, and the results were compared with CT.
  
  
  RESULTS
  CT showed multiple bone lesions in 68% of the 28 patients, and 71% of the lesions had a diameter <10 mm. In 14 patients who underwent both CT and scintigraphy, bone lesions were detected in 57% by CT and in 79% by scintigraphy, but the location and nature of the identified lesions were considerably different; CT frequently showed small lesions (diameter <10 mm) in the vertebrae and pelvis, which were not detected by scintigraphy, whereas scintigraphy could show lesions in the skull and long bones. Overall, by using both examinations, multiple bone lesions were found for 86% of patients.
  
  
  CONCLUSIONS
  CT is particularly useful to detect small bone lesions. CT and bone scintigraphy are complementary, and therefore both should be performed for bone survey in POEMS syndrome.
authors: Department of Neurology, Graduate School of Medicine, Chiba University, Japan.
authors: Kazumoto
authors: K
authors: Shibuya
authors: Sonoko
authors: S
authors: Misawa
authors: Takuro
authors: T
authors: Horikoshi
authors: Kazuaki
authors: K
authors: Kanai
authors: Sagiri
authors: S
authors: Isose
authors: Saiko
authors: S
authors: Nasu
authors: Yukari
authors: Y
authors: Sekiguchi
authors: Yu-ichi
authors: Y
authors: Noto
authors: Yumi
authors: Y
authors: Fujimaki
authors: Chiaki
authors: C
authors: Nakaseko
authors: Satoshi
authors: S
authors: Kuwabara
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000150:complications* / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods