title: Optimizing outcome after cardiac arrest.
abstract: OBJECTIVE
  To discuss recent data relating to survival rates after cardiac arrest and interventions that can be used to optimize outcome.
  
  
  RESULTS
  A recent analysis of 70 studies indicates that following out-of-hospital cardiac arrest (OHCA), 7.6% of patients will survive to hospital discharge (95% confidence interval 6.7-8.4). Following in-hospital cardiac arrest, 18% of patients will survive to hospital discharge. Survival may be optimized by increasing the rate of bystander cardiopulmonary resuscitation (CPR), which can be achieved by improving recognition of cardiac arrest, simplifying CPR and training more of the community. Feedback systems improve the quality of CPR but this has yet to be translated into improved outcome. One study has shown improved survival following OHCA with active compression-decompression CPR combined with an impedance-threshold device. In those who have no obvious extracardiac cause of OHCA, 70% have at least one significant coronary lesion demonstrable by coronary angiography. Although generally reserved for those with ST-elevation myocardial infarction, primary percutaneous coronary intervention may also benefit OHCA survivors with ECG patterns other than ST elevation. The term 'mild therapeutic hypothermia' has been replaced by the term 'targeted temperature management'; its role in optimizing outcome after cardiac arrest continues to be defined.
  
  
  CONCLUSIONS
  In several centres, survival rates following OHCA are increasing. All links in the chain of survival must be optimized if a good-quality neurological outcome is to be achieved.
authors: Royal United Hospital, Bath, UK. jerry.nolan@nhs.net
authors: Jerry P
authors: JP
authors: Nolan
mesh_terms: D016887:Cardiopulmonary Resuscitation; D003422:Critical Care / Q000458:organization & administration*; D006323:Heart Arrest / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D006801:Humans; D010043:Outcome and Process Assessment, Health Care; D016019:Survival Analysis