title: Topical application of two condensed tannins from the root of Rosa multiflora Thunberg for the treatment of atopic dermatitis (AD) in NC/Nga mice.
abstract: Recently, the isolation of several condensed tannins from the roots of Rosa multiflora Thunberg, a traditional herbal therapy in oriental medicine for rheumatoid arthritis and scabies, was described. Two of the major condensed tannins - procyanidin B-3 (ProB3) and ent-guibourtinidol-(4β → 6)-catechin (RM-1) - were then applied topically to atopic dermatitis-like skin lesions on NC/Nga mice in order to assess their immunomodulatory properties. Both ProB3 and RM-1 significantly reduced the serum levels of eosinophils, IgE and certain Th2 cytokines (IL-4, 5 and 13) (p < 0.05 or 0.01). Additionally, ProB3 and RM-1 significantly reduced both the mRNA and protein expression of COX-2 and iNOS in mouse skin tissues (p < 0.01). Such results strongly suggest that ProB3 and RM-1 may be useful in the treatment allergic skin conditions, most notably atopic dermatitis.
authors: College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea.
authors: Kwan Hee
authors: KH
authors: Park
authors: Sun Eun
authors: SE
authors: Choi
authors: Young Wook
authors: YW
authors: Choi
authors: Do Ik
authors: DI
authors: Lee
authors: Seong Soo
authors: SS
authors: Joo
authors: Mi Sook
authors: MS
authors: Jeong
authors: Hyoweon
authors: H
authors: Bang
authors: Chung Soo
authors: CS
authors: Lee
authors: Mi-Kyung
authors: MK
authors: Lee
authors: Seong Jun
authors: SJ
authors: Seo
authors: Min Won
authors: MW
authors: Lee
mesh_terms: D000287:Administration, Topical; D000818:Animals; D044946:Biflavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D044945:Proanthocyanidins / Q000494:pharmacology / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000378:metabolism; D027826:Rosa / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D018418:Th2 Cells / Q000378:metabolism
chemical_list: D044946:Biflavonoids; D016861:Cyclooxygenase Inhibitors; D016207:Cytokines; D007155:Immunologic Factors; D010936:Plant Extracts; D044945:Proanthocyanidins; D012333:RNA, Messenger; C479581:procyanidin B3; D007073:Immunoglobulin E; D002392:Catechin; D052247:Nitric Oxide Synthase Type II