title: Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects.
abstract: Calcitonin gene-related peptide (CGRP) is the main mediator of trigeminal pain signal. Functional CGRP receptors were detected in trigeminal satellite cells, a specialized type of glia found within the sensory ganglia. CGRP displayed modest pro-inflammatory effects per se on trigeminal satellite cells, while it significantly enhanced IL-1β actions, increasing the expression and activity of cycloxygenase 2 as well as the expression of the inducible form of nitric oxide synthase and IL-1β. CGRP effects were reverted by a specific CGRP receptor antagonist and mimicked by elevation of intracellular cAMP levels. CGRP exerted also minor proinflammatory effects on cortical astrocytes.
authors: Institute of Pharmacology, Catholic University Medical School, L.go F Vito 1, Rome, Italy.
authors: Alice
authors: A
authors: De Corato
authors: Lucia
authors: L
authors: Lisi
authors: Alessandro
authors: A
authors: Capuano
authors: Giuseppe
authors: G
authors: Tringali
authors: Antonella
authors: A
authors: Tramutola
authors: Pierluigi
authors: P
authors: Navarra
authors: Cinzia
authors: C
authors: Dello Russo
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D053583:Interleukin-1beta / Q000819:agonists / Q000502:physiology*; D009443:Neuritis / Q000276:immunology / Q000473:pathology*; D009457:Neuroglia / Q000276:immunology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D027161:Satellite Cells, Perineuronal / Q000276:immunology / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000276:immunology / Q000378:metabolism*; D012668:Trigeminal Ganglion / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D015854:Up-Regulation / Q000276:immunology*
chemical_list: D018836:Inflammation Mediators; D053583:Interleukin-1beta; D018015:Receptors, Calcitonin Gene-Related Peptide