title: Mechanistically distinct nonribosomal peptide synthetases assemble the structurally related antibiotics viomycin and capreomycin.
authors: Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors: Elizabeth A
authors: EA
authors: Felnagle
authors: Angela M
authors: AM
authors: Podevels
authors: John J
authors: JJ
authors: Barkei
authors: Michael G
authors: MG
authors: Thomas
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D002207:Capreomycin / Q000737:chemistry / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D017931:DNA Primers; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D054908:Extensively Drug-Resistant Tuberculosis / Q000188:drug therapy / Q000382:microbiology; D060847:Metabolic Engineering / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development; D046908:Peptide Biosynthesis, Nucleic Acid-Independent / Q000235:genetics*; D010453:Peptide Synthases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010957:Plasmids; D011994:Recombinant Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D048170:Streptomyces lividans / Q000201:enzymology / Q000235:genetics; D040681:Structural Homology, Protein; D014170:Transformation, Genetic; D014756:Viomycin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D017931:DNA Primers; D011994:Recombinant Proteins; D002207:Capreomycin; D010453:Peptide Synthases; D014756:Viomycin