title: Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.
abstract: Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies.
authors: Department of Chemistry and Center for Nucleic Acids Science and Technology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
authors: Subhadeep
authors: S
authors: Roy
authors: Kimberly J
authors: KJ
authors: Zanotti
authors: Connor T
authors: CT
authors: Murphy
authors: Farial A
authors: FA
authors: Tanious
authors: W David
authors: WD
authors: Wilson
authors: Danith H
authors: DH
authors: Ly
authors: Bruce A
authors: BA
authors: Armitage
mesh_terms: D002942:Circular Dichroism; D004578:Electron Spin Resonance Spectroscopy; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry*; D007700:Kinetics; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D044367:Phase Transition
chemical_list: D009705:Nucleosides; D020135:Peptide Nucleic Acids; D006147:Guanine