title: Synthesis of carbolines by photostimulated cyclization of anilinohalopyridines.
abstract: A general synthetic route to prepare all four carboline regioisomers by photostimulated cyclization of anilinohalopyridines is described. The methodology affords various substituted carbolines in good to excellent yields. In the case of α-carbolines, the S(RN)1 methodology complements previously reported palladium-catalyzed cyclization approaches.
authors: Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA.
authors: Joydev K
authors: JK
authors: Laha
authors: Silvia M
authors: SM
authors: Barolo
authors: Roberto A
authors: RA
authors: Rossi
authors: Gregory D
authors: GD
authors: Cuny
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010782:Photolysis
chemical_list: D000814:Aniline Compounds; D002243:Carbolines; D010165:Palladium