title: Gout and hyperuricaemia in adults with cystic fibrosis.
abstract: Gout has not been described previously as a complication in cystic fibrosis (CF). Here we present data on nine CF patients who have presented with symptoms of acute gout. This gives an estimated prevalence of gout of around 2.5% in our adult CF population, compared to a previously described prevalence in the non-CF population of just over 1%. Serum urate is measured routinely at the annual review in our unit. Mean (SD) serum urate was 0.40 (0.09) mmol/L in male CF patients (n = 108) and 0.31 (0.08) mmol/L in female patients (n = 74). This was significantly greater than in historical controls. Thirty-seven percent of male CF patients and 36% of female patients had serum urate levels above the upper limit of normal.
authors: Manchester Adult Cystic Fibrosis Centre, Wythenshawe Hospital, Manchester, UK. alex.horsley@nhs.net
authors: Alex
authors: A
authors: Horsley
authors: Jennifer
authors: J
authors: Helm
authors: Amanda
authors: A
authors: Brennan
authors: Rowland
authors: R
authors: Bright-Thomas
authors: Kevin
authors: K
authors: Webb
authors: Andrew
authors: A
authors: Jones
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006073:Gout / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D014527:Uric Acid