title: Effect of quinolinyl acrylate derivatives on prostate cancer in vitro and in vivo.
abstract: Quinolines and acrylates are chemical compounds which were previously described as potential antitumor agents. In this study, a series of seven new quinolinyl acrylate derivatives were synthesized and evaluated against human prostate cancer cells PC-3 and LNCaP in vitro and in vivo. The most effective compound (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4 hydroxyphenyl) acrylate reduced the viability in both cell lines in a time- and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on the neoangiogenesis, clonogenic and MMP-9 activity. The effect in vivo was studied in PC-3 xenografts in nude mice. The results were concordant with the in vitro effects and showed decreased tumor growth in treated animals compared to controls. The study suggests the multi-target efficacy of the quinolinyl derivate against human prostate cancer cells and supports its potential therapeutic usefulness.
authors: Department of Urology, University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, 10117 Berlin, Germany.
authors: Juan R
authors: JR
authors: Rodrigues
authors: Jaime
authors: J
authors: Charris
authors: Rosa
authors: R
authors: Ferrer
authors: Neira
authors: N
authors: Gamboa
authors: Jorge
authors: J
authors: Angel
authors: Bianca
authors: B
authors: Nitzsche
authors: Michael
authors: M
authors: Hoepfner
authors: Michael
authors: M
authors: Lein
authors: Klaus
authors: K
authors: Jung
authors: Claudia
authors: C
authors: Abramjuk
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002448:Cell Adhesion / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002645:Chickens; D002999:Clone Cells; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D018919:Neovascularization, Physiologic / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors; D023041:Xenograft Model Antitumor Assays
chemical_list: D000179:Acrylates; D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D011804:Quinolines; D020780:Matrix Metalloproteinase 9