title: Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7-chloroquinolines (n=3' or 4') against Plasmodium falciparum in in vitro models.
abstract: The synthesis (Pd-mediated coupling strategy) and characterization (NMR, IR, elemental analysis, etc.) of a short series of quinoline-oxazole hybrid compounds has been carried out. These materials are found to be moderately active against Plasmodium falciparum in vitro, with activities in the sub-micromolar range, and to display acceptable cytotoxicity to mononuclear leukocytes. Chemical modification strategies, with the intention to increase the biological potency of this new class of anti-malarial agents, are discussed.
authors: Department of Biology, Acadia University, Wolfville, NS, Canada.
authors: Erin E
authors: EE
authors: Gordey
authors: Paras N
authors: PN
authors: Yadav
authors: Marcus P
authors: MP
authors: Merrin
authors: Jill
authors: J
authors: Davies
authors: Steven A
authors: SA
authors: Ward
authors: Grant M J
authors: GM
authors: Woodman
authors: Amber L
authors: AL
authors: Sadowy
authors: Todd G
authors: TG
authors: Smith
authors: Robert A
authors: RA
authors: Gossage
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002738:Chloroquine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008954:Models, Biological; D010080:Oxazoles / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000737:chemistry
chemical_list: D000962:Antimalarials; D010080:Oxazoles; D011804:Quinolines; D002738:Chloroquine; C037219:quinoline