title: Genome sequence and analysis of the tuber crop potato.
abstract: Potato (Solanum tuberosum L.) is the world's most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop.
authors: BGI-Shenzhen, Chinese Ministry of Agricultural, Key Lab of Genomics, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China.
authors: Xun
authors: X
authors: Xu
authors: Shengkai
authors: S
authors: Pan
authors: Shifeng
authors: S
authors: Cheng
authors: Bo
authors: B
authors: Zhang
authors: Desheng
authors: D
authors: Mu
authors: Peixiang
authors: P
authors: Ni
authors: Gengyun
authors: G
authors: Zhang
authors: Shuang
authors: S
authors: Yang
authors: Ruiqiang
authors: R
authors: Li
authors: Jun
authors: J
authors: Wang
authors: Gisella
authors: G
authors: Orjeda
authors: Frank
authors: F
authors: Guzman
authors: Michael
authors: M
authors: Torres
authors: Roberto
authors: R
authors: Lozano
authors: Olga
authors: O
authors: Ponce
authors: Diana
authors: D
authors: Martinez
authors: Germán
authors: G
authors: De la Cruz
authors: S K
authors: SK
authors: Chakrabarti
authors: Virupaksh U
authors: VU
authors: Patil
authors: Konstantin G
authors: KG
authors: Skryabin
authors: Boris B
authors: BB
authors: Kuznetsov
authors: Nikolai V
authors: NV
authors: Ravin
authors: Tatjana V
authors: TV
authors: Kolganova
authors: Alexey V
authors: AV
authors: Beletsky
authors: Andrei V
authors: AV
authors: Mardanov
authors: Alex
authors: A
authors: Di Genova
authors: Daniel M
authors: DM
authors: Bolser
authors: David M A
authors: DM
authors: Martin
authors: Guangcun
authors: G
authors: Li
authors: Yu
authors: Y
authors: Yang
authors: Hanhui
authors: H
authors: Kuang
authors: Qun
authors: Q
authors: Hu
authors: Xingyao
authors: X
authors: Xiong
authors: Gerard J
authors: GJ
authors: Bishop
authors: Boris
authors: B
authors: Sagredo
authors: Nilo
authors: N
authors: Mejía
authors: Wlodzimierz
authors: W
authors: Zagorski
authors: Robert
authors: R
authors: Gromadka
authors: Jan
authors: J
authors: Gawor
authors: Pawel
authors: P
authors: Szczesny
authors: Sanwen
authors: S
authors: Huang
authors: Zhonghua
authors: Z
authors: Zhang
authors: Chunbo
authors: C
authors: Liang
authors: Jun
authors: J
authors: He
authors: Ying
authors: Y
authors: Li
authors: Ying
authors: Y
authors: He
authors: Jianfei
authors: J
authors: Xu
authors: Youjun
authors: Y
authors: Zhang
authors: Binyan
authors: B
authors: Xie
authors: Yongchen
authors: Y
authors: Du
authors: Dongyu
authors: D
authors: Qu
authors: Merideth
authors: M
authors: Bonierbale
authors: Marc
authors: M
authors: Ghislain
authors: Maria del Rosario
authors: Mdel R
authors: Herrera
authors: Giovanni
authors: G
authors: Giuliano
authors: Marco
authors: M
authors: Pietrella
authors: Gaetano
authors: G
authors: Perrotta
authors: Paolo
authors: P
authors: Facella
authors: Kimberly
authors: K
authors: O'Brien
authors: Sergio E
authors: SE
authors: Feingold
authors: Leandro E
authors: LE
authors: Barreiro
authors: Gabriela A
authors: GA
authors: Massa
authors: Luis
authors: L
authors: Diambra
authors: Brett R
authors: BR
authors: Whitty
authors: Brieanne
authors: B
authors: Vaillancourt
authors: Haining
authors: H
authors: Lin
authors: Alicia N
authors: AN
authors: Massa
authors: Michael
authors: M
authors: Geoffroy
authors: Steven
authors: S
authors: Lundback
authors: Dean
authors: D
authors: DellaPenna
authors: C Robin
authors: CR
authors: Buell
authors: Sanjeev Kumar
authors: SK
authors: Sharma
authors: David F
authors: DF
authors: Marshall
authors: Robbie
authors: R
authors: Waugh
authors: Glenn J
authors: GJ
authors: Bryan
authors: Marialaura
authors: M
authors: Destefanis
authors: Istvan
authors: I
authors: Nagy
authors: Dan
authors: D
authors: Milbourne
authors: Susan J
authors: SJ
authors: Thomson
authors: Mark
authors: M
authors: Fiers
authors: Jeanne M E
authors: JM
authors: Jacobs
authors: Kåre L
authors: KL
authors: Nielsen
authors: Mads
authors: M
authors: Sønderkær
authors: Marina
authors: M
authors: Iovene
authors: Giovana A
authors: GA
authors: Torres
authors: Jiming
authors: J
authors: Jiang
authors: Richard E
authors: RE
authors: Veilleux
authors: Christian W B
authors: CW
authors: Bachem
authors: Jan
authors: J
authors: de Boer
authors: Theo
authors: T
authors: Borm
authors: Bjorn
authors: B
authors: Kloosterman
authors: Herman
authors: H
authors: van Eck
authors: Erwin
authors: E
authors: Datema
authors: Bas te Lintel
authors: Bt
authors: Hekkert
authors: Aska
authors: A
authors: Goverse
authors: Roeland C H J
authors: RC
authors: van Ham
authors: Richard G F
authors: RG
authors: Visser
mesh_terms: D019143:Evolution, Molecular; D020440:Gene Duplication; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant / Q000235:genetics; D014644:Genetic Variation; D018745:Genome, Plant / Q000235:genetics*; D023281:Genomics; D006239:Haplotypes / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D007113:Immunity, Innate; D007178:Inbreeding; D058977:Molecular Sequence Annotation; D008969:Molecular Sequence Data; D010935:Plant Diseases / Q000235:genetics; D011003:Ploidies; D011198:Solanum tuberosum / Q000235:genetics* / Q000502:physiology