title: Mouse strain differences in phencyclidine-induced behavioural changes.
abstract: Administration of phencyclidine (PCP) is acknowledged to generate a model of psychosis in animals. With the identification of genetic susceptibility factors for schizophrenia and bipolar disorder, great efforts have been made to generate genetic animal models for major mental illnesses. As these disorders are multifactorial, comparisons among drug-induced (non-genetic) and genetic models are becoming an important issue in biological psychiatry. A major barrier is that the standard mouse strain used in the generation of genetic models is C57BL/6, whereas almost all studies with PCP-induced models have utilized other strains. To fill this technical gap, we systematically compared the behavioural changes upon PCP administration in different mouse strains, including C57BL/6N, C57BL/6J, ddY, and ICR. We observed strain differences in PCP-induced hyperlocomotion and enhanced immobility in the forced swim test (ddY>>C57BL/6N and 6J>ICR). In contrast, there was no strain difference in the impairment of recognition memory in the novel object recognition memory test after withdrawal of chronic PCP administration. This study provides practical guidance for comparing genetic with PCP-induced models of psychosis in C57BL/6. Furthermore, such strain differences may provide a clue to the biological mechanisms underlying PCP-induced endophenotypes possibly relevant to major mental illnesses.
authors: Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
authors: Akihiro
authors: A
authors: Mouri
authors: Takenao
authors: T
authors: Koseki
authors: Shiho
authors: S
authors: Narusawa
authors: Minae
authors: M
authors: Niwa
authors: Takayoshi
authors: T
authors: Mamiya
authors: Shin-Ichi
authors: S
authors: Kano
authors: Akira
authors: A
authors: Sawa
authors: Toshitaka
authors: T
authors: Nabeshima
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D021461:Animals, Outbred Strains; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism; D006213:Hallucinogens / Q000009:adverse effects*; D006948:Hyperkinesis / Q000139:chemically induced* / Q000235:genetics* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D010622:Phencyclidine / Q000009:adverse effects*; D013045:Species Specificity; D013550:Swimming; D013997:Time Factors
chemical_list: D006213:Hallucinogens; D010622:Phencyclidine