title: Histone H3 phosphoacetylation is critical for heroin-induced place preference.
abstract: We investigated the role of histone H3 phosphoacetylation in the nucleus accumbens (NAc) in heroin-conditioned place preference paradigm. Heroin could dose-dependently increase histone H3 phosphoacetylation specifically in the NAc and could enhance heroin place preference. Injection of trichostatin A into the NAc significantly augmented heroin-induced histone H3 phosphoacetylation and enhanced heroin place preference. Conversely, injection of MK-801 into the NAc attenuated histone H3 phosphoacetylation and reduced heroin place preference. These data suggest that histone H3 phosphoacetylation in the NAc may play a critical role in heroin addiction.
authors: Pharmacology Research Center and State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China.
authors: Jian
authors: J
authors: Sheng
authors: Zhi gang
authors: Zg
authors: Lv
authors: Lei
authors: L
authors: Wang
authors: Yuqing
authors: Y
authors: Zhou
authors: Bin
authors: B
authors: Hui
mesh_terms: D000107:Acetylation; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003216:Conditioning, Operant / Q000187:drug effects*; D003932:Heroin / Q000494:pharmacology*; D006556:Heroin Dependence / Q000378:metabolism / Q000503:physiopathology; D006657:Histones / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009294:Narcotics / Q000494:pharmacology*; D010766:Phosphorylation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D006657:Histones; D009294:Narcotics; D003932:Heroin