title: A new phenolic compound with anticancer activity from the wood of Millettia leucantha.
abstract: A new phenolic compound, 1-(3-hydroxy-4-methoxyphenyl)-3-(2,4-dihydroxy-5-methoxyphenyl) propan-1-ol, named as millettinol (1), along with six known compounds, medicarpin (2), 4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan (3), 5,4'-dihydroxy-7,8-dimethoxyisoflavone (4), physcion (5), (R)-(-)-mellein (6) and isoliquiritigenin (7), were isolated from the wood of Millettia leucantha. The structures of the compounds were determined by an analysis of their spectroscopic data. Some of the isolates were tested for anticancer activity. Compound 1 exhibited strong cytotoxicity against the BCA-1 tumor cell lines with an IC(50) = 3.44 μg/mL.
authors: Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom, 73000 Thailand. kanok-on@su.ac.th
authors: Kanok-On
authors: KO
authors: Rayanil
authors: Pastraporn
authors: P
authors: Bunchornmaspan
authors: Pittaya
authors: P
authors: Tuntiwachwuttikul
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D033641:Millettia / Q000737:chemistry*; D010636:Phenols / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D020005:Propanols / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D014934:Wood
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010636:Phenols; D010936:Plant Extracts; D020005:Propanols; C562032:millettinol