title: Correlation among standard endoscopy, narrow band imaging, and histopathological findings in the diagnosis of nonerosive reflux disease.
abstract: OBJECTIVE
  Gastroesophageal reflux disease (GERD) is caused by the reflux of gastric contents into the esophagus. Narrow band imaging (NBI) facilitates mucosal surface evaluation and may improve the endoscopic diagnosis of GERD. The diagnosis of GERD is based on the combination of clinical symptoms, endoscopic findings, and histological changes. In this study we aimed to show the differences between standard white light endoscopy and the NBI technique in squamo-columnar junction evaluation. We also evaluated the patients with NERD, as determined by standard white light endoscopy, using the NBI technique and histopathological mucosa examination (inflammation or normal mucosa).
  
  
  METHODS
  A total of 60 subjects were recruited prospectively: 40 with nonerosive reflux disease (NERD) and 20 with erosive reflux disease (ERD). Patients were subjected to esophagogastroduodenoscopy and, in all of them, two biopsies were taken 2 cm above the esophagogastric junction.
  
  
  RESULTS
  NBI was more sensitive than standard white light endoscopy in distinguishing normal endoscopic findings. Histopathological findings were more prevalent than the mucosal changes diagnosed by the standard white light endoscopy and NBI.
  
  
  CONCLUSIONS
  NBI is more sensitive than white light endoscopy in detecting inflammation in NERD patients. However, histopathological evaluation is the most sensitive, therefore taking a biopsy will remain useful.
authors: Department of Gastroenterology, Celal Bayar University, Faculty of Medicine, Manisa, Turkey. elmaskasap@yahoo.com
authors: Elmas
authors: E
authors: Kasap
authors: Müjdat
authors: M
authors: Zeybel
authors: Gülcan
authors: G
authors: Aşık
authors: Semin
authors: S
authors: Ayhan
authors: Hakan
authors: H
authors: Yüceyar
mesh_terms: D000328:Adult; D001706:Biopsy; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity