title: AGE-RAGE interaction and oxidative stress in obesity-related renal dysfunction.
abstract: Obesity is a risk factor for development of kidney disease. Advanced glycation end products (AGEs) and the receptor for AGEs (RAGE) play important roles in the pathogenesis of renal disorders that are not associated with diabetes. Harcourt et al. provide evidence to support the mechanism responsible for AGE-RAGE interaction and the downstream oxidative stress and inflammation in obesity-related dysfunction. These findings might provide a new strategy for kidney disease in obesity.
authors: Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan. yasu@juntendo.ac.jp
authors: Yasuhiko
authors: Y
authors: Tomino
authors: Shinji
authors: S
authors: Hagiwara
authors: Tomohito
authors: T
authors: Gohda
mesh_terms: D000818:Animals; D017127:Glycation End Products, Advanced / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000178:diet therapy*; D008297:Male; D009765:Obesity / Q000178:diet therapy* / Q000503:physiopathology*; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000187:drug effects*
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic