title: Estradiol supplementation during the luteal phase in poor responder patients undergoing in vitro fertilization: a randomized clinical trial.
abstract: OBJECTIVE
  This study was designed to evaluate the effects of adding Estradiol (E2) supplementation to progesterone (P) on improvement of pregnancy outcomes in poor responder patients who underwent in vitro fertilization (IVF).
  
  
  METHODS
  In a prospective randomized clinical trial, 118 poor responder patients, older than 38 years without contraindications of estradiol consumption from Infertility clinic of a university hospital were randomly divided (by computerized software) into two groups. Control group (59 patients) received only P and intervention group (59 patients) received P and E2 (4 mg/d). Supplementation was done with 4 mg E2 in the luteal phase. Fertilization rate, implantation rate, biochemical and clinical pregnancy rates, abortion rate, ongoing pregnancy, multiple pregnancy and ectopic pregnancy rates were documented for those who completed the study protocol in each group (per protocol analysis) and compared between groups.
  
  
  RESULTS
  Fifty five patients in control group and 53 patients in intervention group successfully completed the study protocol. Treatment outcomes were not significantly different between two groups.
  
  
  CONCLUSIONS
  For poor responder women who underwent IVF, addition of E2 to P supplementation could not significantly improve pregnancy outcomes.
authors: Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, Zanjan, Iran.
authors: Marzieh
authors: M
authors: Aghahosseini
authors: Ashraf
authors: A
authors: Aleyassin
authors: Sepideh
authors: S
authors: Khodaverdi
authors: Fatemeh
authors: F
authors: Esfahani
authors: Robabeh
authors: R
authors: Mohammadbeigi
authors: Shohreh
authors: S
authors: Movahedi
authors: Ali
authors: A
authors: Kord Valeshabad
authors: Atossa
authors: A
authors: Mahdavi
authors: Parvin
authors: P
authors: Fallahi
authors: Parisa
authors: P
authors: Shabani
authors: Zahra
authors: Z
authors: Rezaeeian
authors: Maryam
authors: M
authors: Khodaverdi
mesh_terms: D000328:Adult; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000627:therapeutic use
chemical_list: D011374:Progesterone; D004958:Estradiol