title: Myotonic dystrophy mouse models: towards rational therapy development.
abstract: DNA repeat expansions can result in the production of toxic RNA. RNA toxicity has been best characterised in the context of myotonic dystrophy. Nearly 20 mouse models have contributed significant and complementary insights into specific aspects of this novel disease mechanism. These models provide a unique resource to test pharmacological, anti-sense, and gene-therapy therapeutic strategies that target specific events of the pathobiological cascade. Further proof-of-principle concept studies and preclinical experiments require critical and thorough analysis of the multiple myotonic dystrophy transgenic lines available. This review provides in-depth assessment of the molecular and phenotypic features of these models and their contribution towards the dissection of disease mechanisms, and compares them with the human condition. More importantly, it provides critical assessment of their suitability and limitations for preclinical testing of emerging therapeutic strategies.
authors: Inserm U781, Université Paris Descartes, Faculté de Medicine Necker Enfants Malades, Paris, France. mario.pereira@inserm.fr
authors: Mário
authors: M
authors: Gomes-Pereira
authors: Thomas A
authors: TA
authors: Cooper
authors: Geneviève
authors: G
authors: Gourdon
mesh_terms: D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D051743:CCAAT-Enhancer-Binding Protein-delta / Q000235:genetics / Q000378:metabolism; D042622:DNA Repeat Expansion / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005091:Exons / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009223:Myotonic Dystrophy / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D012313:RNA / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C497253:Cebpd protein, mouse; D004268:DNA-Binding Proteins; C479922:Mbnl1 protein, mouse; D016601:RNA-Binding Proteins; D051743:CCAAT-Enhancer-Binding Protein-delta; D012313:RNA