title: Soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in synovial fluid are correlated with disease severity of knee osteoarthritis.
abstract: OBJECTIVE
  This study was aimed to measure soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate the correlation between sLOX-1 levels and the disease severity.
  
  
  METHODS
  Two hundred and sixteen OA patients and 83 healthy controls were enrolled in this study. All OA patients were scored for Kellgren-Lawrence (KL) grade (0-4). The sLOX-1 levels were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  In OA patients, the mean sLOX-1 levels in SF were markedly lower than those in paired serum samples (P<0.01). The SF sLOX-1 levels increased with higher KL grade (P<0.01) and were significantly correlated with disease severity (r = 0.324, P<0.01). SF sLOX-1 level was the independent factor for predicting the disease severity of OA (β: 0.281, 95%CI: 0.145-0.396).
  
  
  CONCLUSIONS
  SF sLOX-1 levels were independently and positively associated with disease severity in knee OA.
authors: School of Basic Medical Sciences, Fujian Medical University, Fuzhou,PR China.
authors: Chun-Zhi
authors: CZ
authors: Yang
authors: Department of Orthopedics, Fuzhou Second Hospital, Fuzhou,PR China.
authors: Yi-Yuan
authors: YY
authors: Zhang
authors: School of Basic Medical Sciences, Fujian Medical University, Fuzhou,PR China. Electronic address: fjzhengming@163.com.
authors: Ming
authors: M
authors: Zheng
mesh_terms: D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020370:Osteoarthritis, Knee / Q000175:diagnosis* / Q000473:pathology; D051127:Scavenger Receptors, Class E / Q000032:analysis*; D012720:Severity of Illness Index; D012995:Solubility; D013582:Synovial Fluid / Q000737:chemistry*
chemical_list: C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E