title: Risk estimation for a malignant transformation of oral lesions by S100A7 and Doc-1 gene expression.
abstract: The objective of this study was the correlation of Doc-1- and S100A7-gene expression in common oral lesions with their cancerous-transformation risk. Biopsies (n = 15 each) of healthy gingiva, irritation fibromas, leukoplakias and Oral squamous cell carcinoma (OSCCs) were obtained, and after RNA-extraction, transcripts of Doc-1 and S100A7 were quantified by RT-PCR. In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 was upregulated in all lesions. As the extent of Doc-1-inactivation and S100A7-overexpression is correlated with their biological behavior, the combined investigation of both genes could be a promising marker in intraoral lesions to estimate the risk for their malignant transformation.
authors: Department of Oral & Maxillofacial Plastic Surgery, University of Bonn, Germany.
authors: Jochen
authors: J
authors: Winter
authors: Annette
authors: A
authors: Pantelis
authors: Rudolf
authors: R
authors: Reich
authors: Soeren
authors: S
authors: Jepsen
authors: Jean Piere
authors: JP
authors: Allam
authors: Natalija
authors: N
authors: Novak
authors: Matthias
authors: M
authors: Wenghoefer
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D005260:Female; D005350:Fibroma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007972:Leukoplakia, Oral / Q000235:genetics* / Q000473:pathology; D008297:Male; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012306:Risk; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C096151:CDK2AP1 protein, human; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; C089242:S100A7 protein, human; D025521:Tumor Suppressor Proteins