title: Chemical constituents of a marine fungus, Arthrinium sacchari.
abstract: Three new diterpenes, myrocin D (1), libertellenone E (2), and libertellenone F (3), and a new isocoumarin, decarboxyhydroxycitrinone (4), were isolated from the marine fungus Arthrinium sacchari, together with three known compounds (5-7). The structures of 1-4 were elucidated from spectroscopic data (NMR, MS, IR), and the absolute configurations of 1-3 were determined by X-ray diffraction analysis. The antiangiogenic activity of these compounds was evaluated by measuring their antiproliferation effects on human umbilical vein endothelial cells (HUVECs) and human umbilical artery endothelial cells (HUAECs). Compounds 4-7 showed inhibitory activity.
authors: Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
authors: Mariko
authors: M
authors: Tsukada
authors: Miyuki
authors: M
authors: Fukai
authors: Kazuhiko
authors: K
authors: Miki
authors: Takeshi
authors: T
authors: Shiraishi
authors: Toshihiro
authors: T
authors: Suzuki
authors: Kazuto
authors: K
authors: Nishio
authors: Takashi
authors: T
authors: Sugita
authors: Masahiro
authors: M
authors: Ishino
authors: Kaoru
authors: K
authors: Kinoshita
authors: Kunio
authors: K
authors: Takahashi
authors: Motoo
authors: M
authors: Shiro
authors: Kiyotaka
authors: K
authors: Koyama
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014470:Umbilical Cord / Q000166:cytology / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors; D004224:Diterpenes; D049934:Isocoumarins; C561559:libertellenone E; C561558:libertellenone F; C561557:myrocin D