title: Hippocampal sclerosis in children younger than 2 years.
abstract: BACKGROUND
  Hippocampal sclerosis (HS) is rarely considered as a diagnosis in children younger than 2 years.
  
  
  OBJECTIVE
  To describe imaging features in conjunction with clinical information in patients with hippocampal sclerosis who are younger than 2 years.
  
  
  METHODS
  We retrospectively reviewed MR brain imaging and clinical information in five children in whom the diagnosis of HS was made both clinically and by MRI prior to 2 years of age.
  
  
  RESULTS
  Imaging features establishing the diagnosis of hippocampal sclerosis were bright T2 signal and volume loss, while the internal architecture of the hippocampal formation was preserved in almost all children. Clinically, all children had an infectious trigger.
  
  
  CONCLUSIONS
  It is necessary for radiologists to consider HS in children with certain clinical features to plan an MRI protocol that is appropriate for detection of hippocampal pathology.
authors: Department of Diagnostic Imaging and Radiology, Children's National Medical Center, 111 Michigan Ave, Washington, DC 20010, USA. nkadom@cnmc.org
authors: Nadja
authors: N
authors: Kadom
authors: Tammy
authors: T
authors: Tsuchida
authors: William D
authors: WD
authors: Gaillard
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012189:Retrospective Studies; D012598:Sclerosis; D012640:Seizures / Q000473:pathology