title: A spatial view of the CD8+ T-cell response: the case of HCV.
abstract: In viral infections, a memory T-cell population comprises multiple subtypes of cells, distributed in diverse anatomic compartments and possibly re-circulating among them. Accordingly, memory T cells display distinct phenotypes and functions, depending on the nature of the infecting virus, the anatomic location of the infection, and the differences between the sites of active infection and T-cell collection. This paper explores the body compartments where virus-specific CD8(+) T cells have been found during chronic hepatitis C virus infection, describes the cells' memory qualities, and discusses how they are spatially regulated, in comparison with other human viral infections. Understanding the role of compartmentalization and diversity of HCV-specific memory T-cell subsets may be the key to developing effective immunotherapies.
authors: Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy. v.racanelli@dimo.uniba.it
authors: Vito
authors: V
authors: Racanelli
authors: Patrizia
authors: P
authors: Leone
authors: Arash
authors: A
authors: Grakoui
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016174:Hepacivirus / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D016176:T-Lymphocyte Subsets / Q000276:immunology