title: Atherogenic dyslipidemia in patients with transient ischemic attack.
abstract: OBJECTIVE
  There is mounting evidence that atherogenic dyslipidemia (ie, low high-density lipoprotein cholesterol combined with high triglyceride concentrations) is an independent predictor of high cardiovascular risk and possibly of stroke.
  
  
  METHODS
  All patients included in the SOS-TIA cohort underwent an initial standardized evaluation, including medical history, physical examination, routine blood biochemistry, and diagnostic testing, and were followed for 1 year. Lipid profile was evaluated under fasting conditions. Atherogenic dyslipidemia was defined as high-density lipoprotein cholesterol blood concentration ≤ 40 mg/dL and triglycerides ≥ 150 mg/dL.
  
  
  RESULTS
  Among 1471 consecutive patients with transient ischemic attack (TIA) or minor stroke, overall prevalence of atherogenic dyslipidemia was 5.8%, but varied from 4.6% to 11.1%, depending on final diagnosis (possible TIA or TIA with a cerebral ischemic lesion, respectively). Prevalence of atherogenic dyslipidemia was independently associated with male sex, diabetes, and body mass index, but not with ABCD2 score. Atherogenic dyslipidemia also strongly associated with symptomatic intracranial stenosis ≥ 50% (adjusted odds ratio, 2.77; 95% CI, 1.38-5.55), but not with symptomatic extracranial stenosis ≥ 50% (adjusted odds ratio, 1.20; 95% CI, 0.64-2.26). Despite appropriate secondary prevention treatment, 90-day stroke risk was greater in patients with versus without atherogenic dyslipidemia (4.8% versus 1.7%; P=0.04).
  
  
  CONCLUSIONS
  The atherogenic dyslipidemia phenotype in patients with TIA may be associated with intracranial artery stenosis and higher risk of early recurrent stroke. Additional data are needed to confirm these findings and to assess the best way to reduce important residual risk in such patients.
authors: INSERM U-698 and Paris-Diderot University, Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France.
authors: Gaia
authors: G
authors: Sirimarco
authors: Dominique
authors: D
authors: Deplanque
authors: Philippa C
authors: PC
authors: Lavallée
authors: Julien
authors: J
authors: Labreuche
authors: Elena
authors: E
authors: Meseguer
authors: Lucie
authors: L
authors: Cabrejo
authors: Céline
authors: C
authors: Guidoux
authors: Jean-Marc
authors: JM
authors: Olivot
authors: Halim
authors: H
authors: Abboud
authors: Bertrand
authors: B
authors: Lapergue
authors: Isabelle F
authors: IF
authors: Klein
authors: Mikael
authors: M
authors: Mazighi
authors: Pierre-Jean
authors: PJ
authors: Touboul
authors: Eric
authors: E
authors: Bruckert
authors: Pierre
authors: P
authors: Amarenco
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012306:Risk; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides