title: Langerhans' cell histiocytosis (LCH) in adolescence presented with central diabetes insipidus: a case report.
abstract: A 19-year-old Thai man presented with symptoms of central diabetes insipidus, exopthalmos and multiple ostolytic lesions of the cranial vault. Skin biopsy showed strongly positive CD 1a and S100. Electron microscopy showed rod shape and pentalaminar granules called "Birbeck" granules, a diagnosis compatible with Langerhans' cell histiocytosis (LCHs) or histiocytosis X. He was successfully treated with systemic chemotherapy.
authors: Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand. maisathit@hotmail.com
authors: Sathit
authors: S
authors: Niramitmahapanya
authors: Chaicharn
authors: C
authors: Deerochanawong
authors: Tawatchai
authors: T
authors: Suwanbun
authors: Onsiri
authors: O
authors: Serirat
authors: Usakorn
authors: U
authors: Utrapichart
authors: Siripan
authors: S
authors: Kalayanarooj
authors: Thiti
authors: T
authors: Kuakpaetoon
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D001706:Biopsy; D020790:Diabetes Insipidus, Neurogenic / Q000209:etiology*; D003937:Diagnosis, Differential; D004358:Drug Therapy; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D014747:Vinblastine; D011239:Prednisolone