title: The IL-23 axis in Salmonella gastroenteritis.
abstract: Non-typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin-23 (IL-23)-dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL-23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.
authors: Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA, USA.
authors: Ivan
authors: I
authors: Godinez
authors: A Marijke
authors: AM
authors: Keestra
authors: Alanna
authors: A
authors: Spees
authors: Andreas J
authors: AJ
authors: Bäumler
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005759:Gastroenteritis / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D006801:Humans; D053759:Interleukin-23 / Q000172:deficiency / Q000276:immunology*; D012475:Salmonella / Q000276:immunology* / Q000472:pathogenicity*; D012480:Salmonella Infections / Q000276:immunology* / Q000473:pathology*; D018805:Sepsis / Q000276:immunology / Q000382:microbiology / Q000473:pathology
chemical_list: D053759:Interleukin-23