title: Biomimetic peptide bond formation in water with aminoacyl phosphate esters.
abstract: Aminoacyl phosphates, biomimetic analogues of aminoacyl adenylates, react efficiently with amino acid esters to form dipeptides with retention of stereochemical integrity. The reactions are selective and occur readily in the presence of nucleophiles other than amino groups on their side chains. Aminoacyl phosphate esters that lack an amino-protecting group are also suitable for peptide bond formation, leading to a simplified overall process.
authors: Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
authors: Raj S
authors: RS
authors: Dhiman
authors: Liliana Guevara
authors: LG
authors: Opinska
authors: Ronald
authors: R
authors: Kluger
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D032701:Biomimetics; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D010755:Organophosphates / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000596:Amino Acids; D004151:Dipeptides; D010755:Organophosphates; D014867:Water