title: [Bone mineral density in patients with type 2 diabetes].
abstract: OBJECTIVE
  To establish whether type 2 diabetes (T2D) is associated with changes in the bone mineral density (BMD) of femoral neck, total hip and lumbar spine.
  
  
  METHODS
  Comparative cross-sectional study that included 450 patients aged 30 years or more; 245 with, and 205 without T2D. Groups were matched by age. Degenerative joint disease, rheumatoid arthritis, neoplasia, renal failure, chronic liver disease, alcohol intake, prior treatment with drugs that modulate the BMD, Diabetes Mellitus Type 1 and other endocrinopathies were exclusion criteria.
  
  
  RESULTS
  In the overall group, the presence of menopause was associated with osteoporosis in the hip (odds ratio -OR-4.2; CI95% 1.4-6.1), whereas T2D was a protective factor (OR 0.8; CI95% 0.4-0.9). Among premenopausal women, central obesity and total adiposity were associated with osteoporosis in the hip (OR 1.9; CI95% 1.1-3.9 and OR 2.1; CI95% 1.2-8.7) and femoral areas (OR 2.1; CI95% 1.2-4.1 and OR 2.3; CI95% 1.3-7.1); T2D remained as protective factor (OR 0.7; CI95% 0.5-0.9 and OR 0.6; CI95% 0.4-0.9). The adjusted analysis by BMI, waist circumference, and total adiposity showed that T2D remained as a protective factor for osteoporosis in the hip (OR 0.8; CI95% 0.6-0.9) and femoral areas (OR 0.7; CI95% 0.5-0.9).
  
  
  CONCLUSIONS
  Our results suggest that T2D is an independent protective factor for osteoporosis.
authors: Unidad Metabólica y Cardiovascular SC de Cuernavaca, Cuernavaca. leobardo_sauque_@hotmail.com
authors: Leobardo
authors: L
authors: Sauque-Reyna
authors: María Alejandra
authors: MA
authors: Salcedo-Parra
authors: Pedro Rafael
authors: PR
authors: Sánchez-Vargas
authors: Juan Daniel
authors: JD
authors: Flores-Helguera
authors: Carmina
authors: C
authors: Badillo-Sánchez
authors: Alfredo
authors: A
authors: Reza-Albarrán
authors: Martha
authors: M
authors: Rodríguez-Morán
authors: Fernando
authors: F
authors: Guerrero-Romero
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D015519:Bone Density; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D005272:Femur Neck / Q000737:chemistry / Q000473:pathology; D006621:Hip Joint / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008159:Lumbar Vertebrae / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000453:epidemiology; D010024:Osteoporosis / Q000453:epidemiology*; D019338:Polypharmacy; D017698:Postmenopause; D017697:Premenopause; D055105:Waist Circumference
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin