title: π-Stacking between Casiopeinas® and DNA bases.
abstract: Casiopeínas® are copper complexes with the general formula [Cu(N-N)(N-O)]NO(3) and [Cu(N-N)(O-O)]NO(3) where N-N denotes a substituted bipyridine or phenanthroline, N-O indicates α-aminoacidate or peptide and O-O represents acetylacetonate or salicylaldehyde. This family of compounds has been evaluated in vitro and in vivo showing cytotoxic, genotoxic, and antineoplastic activity. The action mechanism is still not completely elucidated, but the possibility exists that these compounds interact with DNA by intercalation due to the aromatic moiety. In this work we found, using the properties of the electron density of a π-complex model base-Casiopeína®-base, that the stacking mechanism between Casiopeínas® and DNA bases is due to an electron density deficiency of the ligand of the Casiopeína® which is compensated for by an electron transfer from adenines by a π-π interaction.
authors: Instituto de Química, Universidad Nacional Autónoma de México, México DF 04510, México.
authors: Rodrigo
authors: R
authors: Galindo-Murillo
authors: Joseelyne
authors: J
authors: Hernandez-Lima
authors: Mayra
authors: M
authors: González-Rendón
authors: Fernando
authors: F
authors: Cortés-Guzmán
authors: Lena
authors: L
authors: Ruíz-Azuara
authors: Rafael
authors: R
authors: Moreno-Esparza
mesh_terms: D020029:Base Pairing; D056831:Coordination Complexes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D011789:Quantum Theory; D013237:Stereoisomerism
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D011725:Pyridines; D004247:DNA