title: Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.
abstract: Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratio(allergy-glioma) = 0.40, 95% confidence interval: 0.28, 0.58) versus those who did (odds ratio(allergy-glioma) = 0.76, 95% confidence interval: 0.59, 0.97; P(interaction) = 0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratio(allergy-glioma) = 0.44, 95% confidence interval: 0.29, 0.68) versus those who did not carry (odds ratio(allergy-glioma) = 0.68, 95% confidence interval: 0.54, 0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P = 0.14). No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma.
authors: Department of Neurology, Mayo Clinic, 200 First Street SW,Rochester, MN 55905, USA. Lachance.Daniel@mayo.edu
authors: Daniel H
authors: DH
authors: Lachance
authors: Ping
authors: P
authors: Yang
authors: Derek R
authors: DR
authors: Johnson
authors: Paul A
authors: PA
authors: Decker
authors: Thomas M
authors: TM
authors: Kollmeyer
authors: Lucie S
authors: LS
authors: McCoy
authors: Terri
authors: T
authors: Rice
authors: Yuanyuan
authors: Y
authors: Xiao
authors: Francis
authors: F
authors: Ali-Osman
authors: Frances
authors: F
authors: Wang
authors: Shawn M
authors: SM
authors: Stoddard
authors: Debra J
authors: DJ
authors: Sprau
authors: Matthew L
authors: ML
authors: Kosel
authors: John K
authors: JK
authors: Wiencke
authors: Joseph L
authors: JL
authors: Wiemels
authors: Joseph S
authors: JS
authors: Patoka
authors: Faith
authors: F
authors: Davis
authors: Bridget
authors: B
authors: McCarthy
authors: Amanda L
authors: AL
authors: Rynearson
authors: Joel B
authors: JB
authors: Worra
authors: Brooke L
authors: BL
authors: Fridley
authors: Brian Patrick
authors: BP
authors: O'Neill
authors: Jan C
authors: JC
authors: Buckner
authors: Dora
authors: D
authors: Il'yasova
authors: Robert B
authors: RB
authors: Jenkins
authors: Margaret R
authors: MR
authors: Wrensch
mesh_terms: D000483:Alleles; D001254:Astrocytoma / Q000209:etiology / Q000235:genetics*; D001932:Brain Neoplasms / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005909:Glioblastoma / Q000209:etiology / Q000235:genetics*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*