title: Limonoids from seeds of Thai Xylocarpus moluccensis.
abstract: A new andirobin, thaimoluccensin A (1), and two new phragmalin-type limonoids, thaimoluccensins B (2) and C (3), were isolated from seeds of a Thai mangrove plant, Xylocarpus moluccensis, together with eight known compounds. The structures of these compounds were elucidated on the basis of spectroscopic data. Only 7-deacetylgedunin (7), a gedunin-type limonoid, exhibited significant inhibitory activity against nitric oxide production from activated macrophages with IC(50) value less than 10 μM, suggesting that the compound has anti-inflammatory activity.
authors: Research Centre of Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
authors: Warin
authors: W
authors: Ravangpai
authors: Damrong
authors: D
authors: Sommit
authors: Thapong
authors: T
authors: Teerawatananond
authors: Nuntawan
authors: N
authors: Sinpranee
authors: Tanapat
authors: T
authors: Palaga
authors: Somchai
authors: S
authors: Pengpreecha
authors: Nongnuj
authors: N
authors: Muangsin
authors: Khanitha
authors: K
authors: Pudhom
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000378:metabolism; D012639:Seeds / Q000737:chemistry; D013785:Thailand
chemical_list: D000893:Anti-Inflammatory Agents; D003374:Coumarins; D036701:Limonins; D009569:Nitric Oxide