title: State disparities in colorectal cancer mortality patterns in the United States.
abstract: BACKGROUND
  Colorectal cancer (CRC) mortality rates have been decreasing for many decades in the United States, with the decrease accelerating in the most recent time period. The extent to which this decrease varies across states and its influence on the geographic patterns of rates is unknown.
  
  
  METHODS
  We analyzed the temporal trend in age-standardized CRC death rates for each state from 1990 to 2007 using joinpoint regression. We also examined the change in death rates between 1990-1994 and 2003-2007 using rate ratios with 95% confidence intervals and illustrated the change in pattern using maps. The relationship between the change in mortality rates and CRC screening rates for 2004 by state was examined using Pearson's correlation.
  
  
  RESULTS
  CRC mortality rates significantly decreased in all states except Mississippi between 1990 and 2007 based on the joinpoint model. The decrease in death rates between 1990-1994 and 2003-2007 ranged from 9% in Alabama to greater than 33% in Massachusetts, Rhode Island, New York, and Alaska; Mississippi and Wyoming showed no significant decrease. Generally, the northeastern states showed the largest decreases, whereas southern states showed the smallest decreases. The highest CRC mortality rates shifted from the northeastern states during 1990 to 1994 to the southern states along the Appalachian corridor during 2003 to 2007. The decrease in CRC mortality rates by state correlated strongly with uptake of screening (r = -0.65, P < 0.0001).
  
  
  CONCLUSIONS
  Progress in reducing CRC mortality varies across states, with the Northeast showing the most progress and the South showing the least progress.
  
  
  CONCLUSIONS
  These findings highlight the need for wider dissemination of CRC screening.
authors: Surveillance Research, American Cancer Society, Atlanta, GA 30303, USA.
authors: Deepa
authors: D
authors: Naishadham
authors: Iris
authors: I
authors: Lansdorp-Vogelaar
authors: Rebecca
authors: R
authors: Siegel
authors: Vilma
authors: V
authors: Cokkinides
authors: Ahmedin
authors: A
authors: Jemal
mesh_terms: D015179:Colorectal Neoplasms / Q000401:mortality*; D005260:Female; D054624:Health Status Disparities; D006801:Humans; D008297:Male; D014481:United States / Q000453:epidemiology