title: New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status.
abstract: In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.
authors: Department of Neurosurgery, Tohoku University School of Medicine, 1-1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan.
authors: Ichiyo
authors: I
authors: Shibahara
authors: Yukihiko
authors: Y
authors: Sonoda
authors: Masayuki
authors: M
authors: Kanamori
authors: Ryuta
authors: R
authors: Saito
authors: Toshihiro
authors: T
authors: Kumabe
authors: Teiji
authors: T
authors: Tominaga
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000235:genetics*; D001932:Brain Neoplasms / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D005910:Glioma / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D009154:Mutation; D057089:Pathology, Molecular / Q000379:methods*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human