title: Omentin: a novel link between inflammation, diabesity, and cardiovascular disease.
abstract: Obesity has reached pandemic proportions and is associated with serious cardiometabolic sequelae including insulin resistance, diabetes, dyslipidemia, hypertension, and cardiovascular disease, where adipose tissue-secreted cytokines, that is, adipokines, have been implicated in these processes. Omentin is a novel adipokine preferentially produced by visceral adipose tissue with insulin-sensitizing effects, where circulating levels are decreased in insulin-resistant states, for example, obesity and diabetes. With respect to vascular biology, omentin causes vasodilatation of blood vessels and attenuates C-reactive protein-induced angiogenesis potentially via the nuclear factor B signaling pathway, a potent proinflammatory signaling pathway. Thus, omentin may have beneficial effects on the metabolic syndrome and could potentially be used as a biologic marker and/or pharmacologic agent in this respect.
authors: Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, CV4 7AL Coventry, UK. b.k.tan.1@warwick.ac.uk
authors: Bee K
authors: BK
authors: Tan
authors: Raghu
authors: R
authors: Adya
authors: Harpal S
authors: HS
authors: Randeva
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism*; D016207:Cytokines / Q000502:physiology*; D003920:Diabetes Mellitus / Q000378:metabolism*; D058851:GPI-Linked Proteins / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D037102:Lectins / Q000502:physiology*; D009765:Obesity / Q000378:metabolism*
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins