title: Total synthesis of the antifungal depsipeptide petriellin A.
abstract: We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection. Use of advanced coupling agents for several hindered amides was a feature of the synthesis. The natural product was prepared in overall 5% yield.
authors: Department of Chemistry, La Trobe Institute of Molecular Sciences, La Trobe University, Victoria 3086, Australia.
authors: Marianne M
authors: MM
authors: Sleebs
authors: Denis
authors: D
authors: Scanlon
authors: John
authors: J
authors: Karas
authors: Rani
authors: R
authors: Maharani
authors: Andrew B
authors: AB
authors: Hughes
mesh_terms: D000577:Amides / Q000737:chemistry; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D000935:Antifungal Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C522370:petriellin A