title: [Novel metabolically stable functionally-active mimetic of spermidine].
abstract: Earlier unknown 1,8-diamino-3-methyl-4-azaoctane (gamma-MeSpd) was synthesized. The analogue was not a substrate of ether spermine/spermidine N1-acetyltransferase, or spermine synthase, but was capable to support the growth of DU145 cells with depleted polyamine pool. Such a combination of y-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine and spermidine.
authors: M A
authors: MA
authors: Khomutov
authors: M T
authors: MT
authors: Khivonen
authors: A R
authors: AR
authors: Simonian
authors: Ĭ
authors: Ĭ
authors: Vepsäläinen
authors: L
authors: L
authors: Alkhonen
authors: S N
authors: SN
authors: Kochetkov
authors: T A
authors: TA
authors: Keinänen
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D048708:Cell Growth Processes / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D055550:Protein Stability; D013095:Spermidine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D013096:Spermine / Q000378:metabolism*; D013097:Spermine Synthase / Q000378:metabolism; D013379:Substrate Specificity; D000099228:Diamine N-Acetyltransferase
chemical_list: D000123:Acetyltransferases; D013095:Spermidine; D013096:Spermine; D013097:Spermine Synthase; D000099228:Diamine N-Acetyltransferase; C560108:1,8-diamino-3-methyl-4-azaoctane