title: An unfortunate case of Pendred syndrome.
abstract: OBJECTIVE
  To report a patient with Pendred syndrome who developed life-threatening hypokalaemia as an unpredicted consequence of implant-induced imbalance and alcohol dependency, leading to multiple cardiac arrests.
  
  
  METHODS
  Addenbrooke's Hospital, Cambridge, UK.
  
  
  METHODS
  Case report and review of the English language literature concerning Pendred syndrome and cochlear implantation in Pendred syndrome patients.
  
  
  RESULTS
  Pendred syndrome is an autosomal recessive disorder which mainly affects the inner ear, thyroid and kidneys. It accounts for 10 per cent of syndromic hearing loss cases. The majority of Pendred syndrome patients are referred to cochlear implant programmes for hearing assessment and therapy. They may also have an underlying metabolic abnormality which is not clinically apparent.
  
  
  CONCLUSIONS
  Providing cochlear implants to patients with Pendred syndrome demands extensive knowledge of this condition, in order to avoid potential morbidity.
authors: Department of Otolaryngology, Addenbrooke's Hospital, Cambridge, UK. al.sane@doctors.net.uk
authors: A
authors: A
authors: Sanei-Moghaddam
authors: T
authors: T
authors: Wilson
authors: S
authors: S
authors: Kumar
authors: R
authors: R
authors: Gray
mesh_terms: D000437:Alcoholism / Q000150:complications; D000471:Alkalosis / Q000150:complications; D019929:Cochlear Implantation / Q000009:adverse effects*; D003221:Confusion / Q000150:complications; D005260:Female; D006044:Goiter, Nodular / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics / Q000534:rehabilitation / Q000601:surgery*; D006323:Heart Arrest / Q000150:complications / Q000534:rehabilitation; D006801:Humans; D007037:Hypothyroidism; D026901:Membrane Transport Proteins / Q000235:genetics; D008875:Middle Aged; D010349:Patient Compliance; D004856:Postural Balance / Q000502:physiology; D011859:Radiography; D000076988:Sulfate Transporters; D014012:Tinnitus / Q000209:etiology; D006113:United Kingdom; D014693:Ventricular Fibrillation; D014839:Vomiting / Q000150:complications
chemical_list: D026901:Membrane Transport Proteins; C085609:SLC26A4 protein, human; D000076988:Sulfate Transporters