title: Characteristics of children with positive tuberculin skin test.
abstract: The aim of the study was to define the characteristics of children with latent tuberculosis diagnosed with positive tuberculin skin test (TST) and evaluate potential risk factors in children with positive TST. Children followed with the diagnosis of latent tuberculosis infection were included in the study retrospectively. Demographic characteristics of patients including history of atopy, respiratory infections, family history of tuberculosis and atopy, number of BCG vaccinations, findings of physical examination and laboratory data were extracted from patient's file. Eighty-one children (51 male, 30 female) who had positive TST were retrospectively evaluated in the study. Mean age of the patients was 8.00 ± 4.00 years. Only 13 (16%) of the children had contact with a case who had active tuberculosis. It was shown that the age of the patients, number of BCG scars and BCG vaccination significantly affected TST reaction size. TST size was not affected with time passed after last dose of BCG vaccination, family history of tuberculosis, presence of TST positive case in the family, exposure to cigarette smoke, number of household family members and presence of respiratory allergic disease. The patient's age, numbers of BCG vaccination and BCG scars significantly affect TST results in childhood. This may cause difficulty in diagnosing latent tuberculosis infection and in decision of initiating prophylactic treatment. The results of this study may show that recently developed, more accurate and convenient in vitro tests that they have higher costs and require sophisticated laboratory, can be used to diagnose latent tuberculosis.
authors: Department of Children Health and Diseases, Division of Children Allergy, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. arbabayigit@yahoo.com
authors: Arzu Babayiğit
authors: AB
authors: Hocaoğlu
authors: Duygu Olmez
authors: DO
authors: Erge
authors: Ozden
authors: O
authors: Anal
authors: Balahan
authors: B
authors: Makay
authors: Nevin
authors: N
authors: Uzuner
authors: Ozkan
authors: O
authors: Karaman
mesh_terms: D001500:BCG Vaccine / Q000008:administration & dosage*; D002648:Child; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000517:prevention & control* / Q000635:transmission; D008168:Lung / Q000473:pathology*; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D014374:Tuberculin Test
chemical_list: D001500:BCG Vaccine