title: Thujone corrects cholesterol and triglyceride profiles in diabetic rat model.
abstract: Thujone, which is the major constituent in Salvia sp. (Lamiaceae), was found to correct the lipid profile (cholesterol and triglycerides) in diabetic rats. Oral treatment with thujone (5 mg kg⁻¹ body weight dose) significantly adjusted cholesterol and triglyceride levels in diabetic rats (p ≤ 0.05) to normal levels compared to diabetic untreated rats. This provides a premise in the field of finding new agents to treat diabetic complications.
authors: Department of Biological Sciences, Faculty of Science, University of Jordan, Amman 11942, Jordan.
authors: Nour W Al-Haj
authors: NW
authors: Baddar
authors: Talal A
authors: TA
authors: Aburjai
authors: Mutasem O
authors: MO
authors: Taha
authors: Ahmad M
authors: AM
authors: Disi
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D000081008:Bicyclic Monoterpenes; D002784:Cholesterol / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy*; D039821:Monoterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D027544:Salvia / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood*
chemical_list: D000081008:Bicyclic Monoterpenes; D039821:Monoterpenes; D010936:Plant Extracts; D014280:Triglycerides; C005790:beta-thujone; D002784:Cholesterol