title: Excellent correlation between drug release and portal size in metalla-cage drug-delivery systems.
abstract: A series of large cationic hexanuclear metalla-prisms, [Ru(6)(p-iPrC(6)H(4)Me)(6)(tpt)(2)(donq)(3)](6+), [Ru(6)(p-iPrC(6)H(4)Me)(6)(tpt)(2)(doaq)(3)](6+) and [Ru(6)(p-iPrC(6)H(4)Me)(6)(tpt)(2)(dotq)(3)](6+), composed of p-cymene-ruthenium building blocks bridged by OO∩OO ligands (donq=5,8-dioxido-1,4-naphthoquinonato; doaq=5,8-dioxido-1,4-anthraquinonato, dotq=6,11-dioxido-5,12-naphthacenedionato) and connected by two 2,4,6-tripyridin-4-yl-1,3,5-triazine (tpt) panels, which encapsulate the guest molecules 1-(4,6-dichloro-1,3,5-triazin-2-yl)pyrene and Pd(acac)(2), have been prepared. The host-guest properties of these water-soluble delivery systems were studied in solution by NMR and fluorescence spectroscopy, providing the stability constants (K) for these host-guest systems. Moreover, the ability of the hosts to deliver the guests into cancer cells was evaluated and the uptake mechanism studied; the rate of release of the guest molecule was found to depend on the portal size of the host.
authors: Institute of Chemistry, University of Neuchatel, Neuchatel, Switzerland.
authors: Nicolas P E
authors: NP
authors: Barry
authors: Olivier
authors: O
authors: Zava
authors: Paul J
authors: PJ
authors: Dyson
authors: Bruno
authors: B
authors: Therrien
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D000081007:Cymenes; D016503:Drug Delivery Systems; D004705:Endocytosis / Q000187:drug effects; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D039821:Monoterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D011721:Pyrenes / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D000081007:Cymenes; D008024:Ligands; D039821:Monoterpenes; D009942:Organometallic Compounds; D011721:Pyrenes; D014227:Triazines; D014867:Water; C007210:4-cymene; D012428:Ruthenium