title: Characterization of the effect of in vivo doxorubicin treatment on skeletal muscle function in the rat.
abstract: Doxorubicin (DOX)-induced muscle dysfunction may contribute to patient fatigue, but the nature of this myotoxicity remains unclear. The purpose of this study was to characterize the muscle function dose-response to DOX. A secondary purpose was to compare the degree of DOX-induced muscle dysfunction to the observed cardiac dysfunction.
  
  
  METHODS
  Rats received DOX at 10 mg/kg (DOX1), 12.5 mg/kg (DOX2), or 15 mg/kg (DOX3). Muscle and cardiac function were assessed 5 days, post injection.
  
  
  RESULTS
  Compared to controls, DOX2 and DOX3 soleus and DOX3 extensor digitorum longus (EDL) had lower maximal twitch force (p<0.05). Soleus fatigue rate was altered by DOX, but EDL fatigue rate was not. Additionally, fractional shortening was lower in DOX2 and DOX3 compared to controls (p<0.05).
  
  
  CONCLUSIONS
  DOX impaired muscle function in a dose-dependent manner. The degree of dysfunction was greater in the soleus and was consistent with the observed cardiac dysfunction.
authors: School of Sport and Exercise Science, University of Northern Colorado, Gunter Hall 2590, Box39, 501 20th Street, Greeley, CO 80639, USA. David.Hydock@unco.edu
authors: David S
authors: DS
authors: Hydock
authors: Chia-Ying
authors: CY
authors: Lien
authors: Brock T
authors: BT
authors: Jensen
authors: Carole M
authors: CM
authors: Schneider
authors: Reid
authors: R
authors: Hayward
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000633:toxicity*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D053580:Muscle Strength / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin