title: Fructose increases the resistance of Rhodobacter capsulatus to the toxic oxyanion tellurite through repression of acetate permease (ActP).
abstract: The highly toxic oxyanion tellurite (TeO(3)                                   (2-)) enters the cells of the facultative photosynthetic bacterium Rhodobacter capsulatus through an acetate permease. Here we show that actP gene expression is down-regulated by fructose and this in turn determines a strong decrease of tellurite uptake and a parallel increase in the cells resistance to the toxic metalloid (from a minimal inhibitory concentration of 8 μM up to 400 μM tellurite under aerobic growth conditions). This demonstrates that there exists a direct connection between the level of tellurite uptake and the sensitivity of the cells to the oxyanion.
authors: Department of Biology, General Microbiology Unit, University of Bologna, via Irnerio 42, Bologna, Italy. roberto.borghese@unibo.it
authors: Roberto
authors: R
authors: Borghese
authors: Silvia
authors: S
authors: Cicerano
authors: Davide
authors: D
authors: Zannoni
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001692:Biological Transport; D015536:Down-Regulation; D005632:Fructose / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D016354:Rhodobacter capsulatus / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D013691:Tellurium / Q000378:metabolism* / Q000633:toxicity
chemical_list: D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D005632:Fructose; C026660:tellurous acid; D013691:Tellurium