title: Scaffolding catalysts: highly enantioselective desymmetrization reactions.
abstract: Ex-changing places: a highly enantioselective desymmetrization of 1,2-diols has been developed in which the catalyst utilizes reversible covalent bonding to the substrate to achieve both high selectivity and rate acceleration (see scheme, PMP=pentalmethylpiperidine, TBS=tert-butyldimethylsilyl). Induced intramolecularity is responsible for the enhanced rate, thus allowing the reaction to be performed at room temperature.
authors: Department of Chemistry, Boston College, Chestnut Hill, MA 02467-3860, USA.
authors: Xixi
authors: X
authors: Sun
authors: Amanda D
authors: AD
authors: Worthy
authors: Kian L
authors: KL
authors: Tan
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D010880:Piperidines / Q000737:chemistry; D012821:Silanes / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D010880:Piperidines; D012821:Silanes; C032727:piperidine