title: Coagulation profile, haematological and biochemical changes in kids naturally infected with peste des petits ruminants.
abstract: The aim of this study was to examine the coagulation profile in peste des petits ruminant (PPR) in kids. Five kids from a group of 150 animals (72 goats and 78 kids) were brought to the Veterinary Medical Teaching Hospital from a farm in Burdur province (Turkey) with nasal and ocular discharges and diarrhea. Fifteen goats and 41 kids had died due to diarrhea and three kids were presented to the Department of Pathology for diagnosis. Blood samples were taken from 12 ill animals (infected group) for haematological and biochemical analysis. In addition, five healthy kids were examined from another healthy flock (control group). Leukocyte and lymphocyte numbers of infected group showed significant declinations in comparison to control group (≤0.001). Haemorrhages in all organs of digestive system and small haemorrhagic areas in liver were caused to decrease in erythrocyte and haematocrit values (p ≤ 0.001) in infected group. Concentrations of blood urea nitrogen (BUN) (p ≤ 0.01) and creatinine (p ≤ 0.001) in infected group were significantly higher than control group. Compared to control group, significant increases were determined in serum concentrations of alkaline phosphatase (ALP) (p ≤ 0.01), aspartate aminotransferase (AST) (p ≤ 0.001) and alanine aminotransferase (ALT) (p ≤ 0.001) in the infected group. No significant differences were observed between the infected and control groups for serum gamma glutamyl-transferase (GGT) concentration value. In our study, thrombocytopenia (p ≤ 0.001) together with prolonged activated partial thromboplastin time (APTT; p ≤ 0.01) and prothrombin time (PT; p ≤ 0.001) may show that disseminated intravascular coagulopathy which can occur in kids with PPR.
authors: Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mehmet, Akif Ersoy, Burdur, Turkey. sahinduran@mehmetakif.edu.tr
authors: Sima
authors: S
authors: Sahinduran
authors: Metin Koray
authors: MK
authors: Albay
authors: Kenan
authors: K
authors: Sezer
authors: Ozlem
authors: O
authors: Ozmen
authors: Nuri
authors: N
authors: Mamak
authors: Mehmet
authors: M
authors: Haligur
authors: Cagri
authors: C
authors: Karakurum
authors: Ramazan
authors: R
authors: Yildiz
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D001777:Blood Coagulation; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D015511:Goat Diseases / Q000097:blood* / Q000473:pathology; D006041:Goats; D010314:Partial Thromboplastin Time / Q000662:veterinary; D029021:Peste-des-Petits-Ruminants / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D018107:Peste-des-petits-ruminants virus / Q000502:physiology*; D011517:Prothrombin Time / Q000662:veterinary; D013921:Thrombocytopenia / Q000097:blood / Q000662:veterinary*; D014421:Turkey