title: Glycogen hepatopathy in a 13-year-old male with type 1 diabetes.
abstract: Glycogenic hepatopathy (GH ) is a rare cause of serum transaminase elevations in type 1 diabetes mellitus. We describe a 13-year-old male with a history of poorly controlled type 1 diabetes mellitus who presented with hepatomegaly and severe transaminase flares. Liver histology confirmed GH. Treatment consists of improving glycemic control. Hepatomegaly due to excess glycogen storage in poorly controlled type 1 diabetics has been associated with younger patients with poor glycemic control, occurring about 2-4 weeks after starting insulin treatment, and resolving upon glucose stabilization. We conclude that glycogenic hepatopathy can cause hepatomegaly and significant transaminase elevations in individuals with type I diabetes mellitus, The recovery of severe transaminase elevations in this patient illustrates the more benign course of GH, which is a condition with a far better prognosis. Clinician awareness of GH should prevent diagnostic delay and will provide better insight into the prevalence of GH.
authors: Department of Medicine, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. khalidsaljabri@yahoo.com
authors: Khalid S
authors: KS
authors: Aljabri
authors: Samia A
authors: SA
authors: Bokhari
authors: Sanaa M
authors: SM
authors: Fageeh
authors: Abdullah M
authors: AM
authors: Alharbi
authors: Mohamad A
authors: MA
authors: Abaza
mesh_terms: D000293:Adolescent; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology; D006529:Hepatomegaly / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D000637:Transaminases / Q000097:blood
chemical_list: D008112:Liver Glycogen; D000637:Transaminases