title: Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population.
abstract: Abstract Objectives. Several lines of evidence have shown that both RELN mRNA and protein are possibly down-regulated in the brain of schizophrenia patients. Recent association studies in European populations suggested RELN as a risk gene for schizophrenia. In this study, we test if RELN contributes to the risk of schizophrenia in Chinese population. Methods. We conducted case-control association analysis of 19 representative single nucleotide polymorphisms (SNPs) spanning the entire region of RELN in two independent Han Chinese samples from southwestern China (the Kunming sample and the Yuxi sample). Results. We identified six SNPs significantly associated with schizophrenia in the Kunming sample and four of them remained significant in the combined samples (the P values range from 0.006 to 4.0 × 10(-5)). Haplotype analysis also suggested significant associations for the haplotypes incorporating the six significant SNPs (global P < 1.0 × 10(-5)). Additionally, we also observed several other haplotypes (defined by a different set of SNPs) significantly associated with schizophrenia in the Kunming sample. However, the reported association of rs7341475 in Ashkenazi Jews was not significant in Han Chinese.
  
  
  CONCLUSIONS
  Our findings demonstrate that RELN is a susceptibility gene for schizophrenia in Chinese population, and it is likely a common risk gene for schizophrenia in major populations worldwide.
authors: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
authors: Ming
authors: M
authors: Li
authors: Xiong-Jian
authors: XJ
authors: Luo
authors: Xiao
authors: X
authors: Xiao
authors: Lei
authors: L
authors: Shi
authors: Xing-Yan
authors: XY
authors: Liu
authors: Li-De
authors: LD
authors: Yin
authors: Xiao-Yuan
authors: XY
authors: Ma
authors: Shun-Ying
authors: SY
authors: Yang
authors: Xing-Fu
authors: XF
authors: Pu
authors: Jin
authors: J
authors: Yu
authors: Hong-Bo
authors: HB
authors: Diao
authors: Hong
authors: H
authors: Shi
authors: Bing
authors: B
authors: Su
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism / Q000473:pathology; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics / Q000378:metabolism; D002681:China; D015536:Down-Regulation; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D000091042:Reelin Protein; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717127:RELN protein, human; D012697:Serine Endopeptidases