title: Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: a potential therapeutic target in colorectal cancer.
abstract: Fibroblast growth factor receptor 2 (FGFR2) is considered a novel therapeutic target for various cancer. We used a silencing strategy to clarify the effect of reduced FGFR2 expression in human colorectal cancer (CRC) cells. The invasive front of cancer cells exhibited stronger FGFR2 expression than the surface area of the cancers. FGFR2 shRNA-transfected LoVo cells inhibited cell migration, invasion and tumor growth in vitro and in vivo. Thus, FGFR2 plays important roles in CRC progression in association with tumor cell migration, invasion and growth, and FGFR2 might be a novel therapeutic target for CRC.
authors: Departments of Pathology and Integrative Oncological Pathology, Nippon Medical School, Tokyo, Japan.
authors: Yoko
authors: Y
authors: Matsuda
authors: Toshiyuki
authors: T
authors: Ishiwata
authors: Kazuya
authors: K
authors: Yamahatsu
authors: Kiyoko
authors: K
authors: Kawahara
authors: Masahito
authors: M
authors: Hagio
authors: Wei-Xia
authors: WX
authors: Peng
authors: Tetsushi
authors: T
authors: Yamamoto
authors: Nando
authors: N
authors: Nakazawa
authors: Tomoko
authors: T
authors: Seya
authors: Yoshiharu
authors: Y
authors: Ohaki
authors: Zenya
authors: Z
authors: Naito
mesh_terms: D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal; D002448:Cell Adhesion; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D018450:Disease Progression; D005109:Extracellular Matrix; D005260:Female; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016133:Polymerase Chain Reaction; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000494:pharmacology*; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000911:Antibodies, Monoclonal; D034741:RNA, Small Interfering; D051497:Receptor, Fibroblast Growth Factor, Type 2