title: Dietary Perilla seed oil supplement increases plasma omega-3 polyunsaturated fatty acids and ameliorates immunoglobulin A nephropathy in high immunoglobulin A strain of ddY mice.
abstract: OBJECTIVE
  The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) in the treatment of immunoglobulin A nephropathy (IgAN) have been reported. Perilla frutescens (Linn.) Britton var. frutescens is grown in Eastern Asia and its seed (perilla seed) is rich in α-linolenic acid, an n-3 PUFA. We investigated the antinephritic effects of perilla seed oil in a mouse model of IgAN.
  
  
  METHODS
  Ten-week-old high IgA ddY mice were fed diets containing either perilla seed oil (PS group) or corn oil (C group, control). After 20 weeks, we compared body weight, blood pressure, serum creatinine levels, IgA levels, fatty acid composition, urinary protein excretion, mesangial matrix expansion, and glomerular transforming growth factor-β1 mRNA expression between groups.
  
  
  RESULTS
  Serum n-3 PUFA levels were higher in the PS group than the C group (p<0.001). Blood urea nitrogen levels were lower (p=0.0246) and urinary protein excretion was reduced (p=0.0198) in the PS group. Mesangial matrix expansion (p=0.0063) and glomerular transforming growth factor-β1 mRNA expression (p=0.0291) were suppressed in the PS group. No significant differences between groups were found in body weight, blood pressure, serum IgA, and creatinine levels.
  
  
  CONCLUSIONS
  Dietary perilla seed oil supplement could suppress the progression of IgAN.
authors: Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors: Kaoru
authors: K
authors: Sakurai
authors: Koichi
authors: K
authors: Asahi
authors: Yoshinobu
authors: Y
authors: Kanesaki
authors: Yoshimitsu
authors: Y
authors: Hayashi
authors: Jun
authors: J
authors: Asai
authors: Toshiki
authors: T
authors: Yuza
authors: Kimio
authors: K
authors: Watanabe
authors: Tetsuo
authors: T
authors: Katoh
authors: Tsuyoshi
authors: T
authors: Watanabe
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000627:therapeutic use*; D015525:Fatty Acids, Omega-3 / Q000097:blood; D005922:Glomerulonephritis, IGA / Q000178:diet therapy* / Q000473:pathology; D051379:Mice; D010938:Plant Oils / Q000627:therapeutic use; D017962:alpha-Linolenic Acid / Q000097:blood / Q000627:therapeutic use*
chemical_list: D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D010938:Plant Oils; D017962:alpha-Linolenic Acid; C058216:perilla seed oil