title: Olfactory memory is impaired in a triple transgenic model of Alzheimer disease.
abstract: Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of Alzheimer's disease (3 × Tg-AD). In the social transmission of food preference test, 3 × Tg-AD mice presented severe deficits in odor-based memory, without gross changes in general odor-ability. Aβ and tau immunoreactivity was not observed in the primary processing regions for odor, the olfactory bulbs (OBs), whereas marked immunostaining was present in the piriform, entorhinal, and orbitofrontal cortex, as well as in the hippocampus. Our results suggest that the impairment in olfactory-based information processing might arise from degenerative mechanisms mostly affecting higher cortical regions and limbic areas, such as the hippocampus.
authors: Department of Biomedical Sciences, University of Foggia, Foggia, 71100, Italy. tommaso.cassano@gmail.com
authors: Tommaso
authors: T
authors: Cassano
authors: Adele
authors: A
authors: Romano
authors: Teresa
authors: T
authors: Macheda
authors: Roberto
authors: R
authors: Colangeli
authors: Concetta Stefania
authors: CS
authors: Cimmino
authors: Antonio
authors: A
authors: Petrella
authors: Frank M
authors: FM
authors: LaFerla
authors: Vincenzo
authors: V
authors: Cuomo
authors: Silvana
authors: S
authors: Gaetani
mesh_terms: D000544:Alzheimer Disease / Q000523:psychology*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D003672:Defecation / Q000502:physiology; D005502:Food; D005518:Food Preferences; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D008568:Memory / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000502:physiology; D009830:Olfactory Bulb / Q000502:physiology; D009833:Olfactory Pathways / Q000502:physiology; D053764:Presenilin-1 / Q000235:genetics; D012903:Smell / Q000502:physiology*; D016875:tau Proteins / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor; D053764:Presenilin-1; D016875:tau Proteins