title: Metam sodium intoxication: the specific role of degradation products--methyl isothiocyanate and carbon disulphide--as a function of exposure.
abstract: Introduction. The objective was to evaluate the toxicity of poisoning by metam sodium, a dithiocarbamate fumigant, the breakdown products of which are methyl isothiocyanate (MITC), carbon disulphide (CS2), and dihydrogen sulphide (H2S). Methods. This is a retrospective, observational case series of metam sodium exposure cases reported to the Angers Poison and Toxicovigilance Centre from 1992 through 2009. Results. A total of 106 cases of metam sodium exposure were recorded and 102 cases were included in this study. All cases of exposure were unintentional. Occupational poisoning occurred in eight cases. The most common route of exposure was inhalation (n = 96). In 79 cases, the patients were people living near fields where metam sodium had recently been applied. Most of the reported symptoms involved irritation of the eyes (n = 76), throat and nose (n = 65), attributable to MITC. Cough and dyspnoea occurred in four cases but no persistent, irritant-induced asthma or persistent exacerbation of asthma was observed. Sixteen patients at two different sites of pollution were exposed to emanations from the drainage system in their homes following the illicit discharge of metam sodium into the sewers. Most presented with nausea and headaches, but only four experienced eye or throat irritation. A breakdown product other than MITC was involved: air analysis at one site revealed the presence of CS2 (337 mg/m(3)) and no H2S. Two of these patients, who had consumed some alcohol, experienced dysgeusia but no disulfiram-like reaction. The only lethal case recorded was a truck driver who was found dead of acute lung injury after falling into a tank that had previously contained metam sodium. Two patients who ingested a dilute solution, presented with mild epigastric pain. Four skin exposures caused erythema (n = 2), moderate burns (n = 1), and urticaria (n = 1). According to the poisoning severity score, their symptoms were minor in 99% of cases. Conclusion. Acute metam sodium exposure usually causes minor symptoms. They vary as a function of the circumstances of exposure, which determine the degradation product that forms. On contact with moist soil, metam sodium decomposes into MITC and causes irritant symptoms. Under specific conditions, such as a spillage in the drainage system, metam sodium can degrade into CS2 and cause neurological signs.
authors: Poisons and Toxicovigilance Centre (PCT), University Hospital Angers, 4 rue Larrey, Angers Cedex 09, France. mabretaudeau@chu-angers.fr
authors: Marie
authors: M
authors: Bretaudeau Deguigne
authors: Laurence
authors: L
authors: Lagarce
authors: David
authors: D
authors: Boels
authors: Patrick
authors: P
authors: Harry
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002246:Carbon Disulfide / Q000506:poisoning*; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019570:Inhalation Exposure; D017879:Isothiocyanates / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D010575:Pesticides / Q000506:poisoning*; D012098:Reproduction / Q000187:drug effects; D012189:Retrospective Studies; D012867:Skin / Q000187:drug effects; D013859:Thiocarbamates / Q000506:poisoning*
chemical_list: D017879:Isothiocyanates; D010575:Pesticides; D013859:Thiocarbamates; C008435:methyldithiocarbamate; C005227:methyl isothiocyanate; D002246:Carbon Disulfide