title: Exploring the potential of telmisartan in chronic constriction injury-induced neuropathic pain in rats.
abstract: The present study was designed to investigate the potential of telmisartan, an angiotensin AT(1) receptor, in chronic constriction injury-induced neuropathic pain in rats. Four loose ligatures were placed around the sciatic nerve to induce chronic constriction injury and neuropathic pain. Acetone drop, pin-prick, hot plate and paint brush tests were performed to assess cold allodynia; mechanical and heat hyperalgesia; and dynamic mechanical allodynia, respectively along with assessment of spontaneous pain and postural index in terms of foot deformity. The levels of TNF-α were measured in the sciatic nerve as an index of inflammation. Chronic constriction injury was associated with development of cold allodynia; mechanical and heat hyperalgesia; dynamic mechanical allodynia; and spontaneous pain and foot deformity along with rise in the levels of TNF-α. Telmisartan (1, 2, 5 mg/kg, p.o.) was administered for 14 days in chronic constriction injury subjected rats. Administration of telmisartan (2, 5 mg/kg) significantly attenuated chronic constriction injury-induced pain related behavior, foot deformity and rise in TNF-α level. It may be concluded that telmisartan has a potential in attenuating neuropathic pain behavior in chronic constriction injury model which may possibly be attributed to its anti-inflammatory properties.
authors: Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147002, Punjab, India.
authors: Amteshwar Singh
authors: AS
authors: Jaggi
authors: Nirmal
authors: N
authors: Singh
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D001565:Benzoates / Q000494:pharmacology* / Q000627:therapeutic use; D003251:Constriction, Pathologic / Q000150:complications; D005260:Female; D005530:Foot Deformities / Q000150:complications; D006930:Hyperalgesia / Q000150:complications; D008297:Male; D009437:Neuralgia / Q000150:complications / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000077333:Telmisartan; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D001562:Benzimidazoles; D001565:Benzoates; D014409:Tumor Necrosis Factor-alpha; D000077333:Telmisartan