title: Dendritic MRI contrast agents: an efficient prelabeling approach based on CuAAC.
abstract: The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) allows the efficient and complete functionalization of dendrimers with preformed Gd chelates (prelabeling) to give monodisperse macromolecular contrast agents (CAs) for magnetic resonance imaging (MRI). This monodispersity contrasts with the typical distribution of materials obtained by classical routes and facilitates the characterization and quality control demanded for clinical applications. The potential of a new family of PEG-dendritic CA based on a gallic acid-triethylene glycol (GATG) core functionalized with up to 27 Gd complexes has been explored in vitro and in vivo, showing contrast enhancements similar to those of Gadomer-17, which reveals them to be a promising platform for the development of CA for MRI.
authors: Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain.
authors: Francisco
authors: F
authors: Fernández-Trillo
authors: Jesús
authors: J
authors: Pacheco-Torres
authors: Juan
authors: J
authors: Correa
authors: Paloma
authors: P
authors: Ballesteros
authors: Pilar
authors: P
authors: Lopez-Larrubia
authors: Sebastián
authors: S
authors: Cerdán
authors: Ricardo
authors: R
authors: Riguera
authors: Eduardo
authors: E
authors: Fernandez-Megia
mesh_terms: D000818:Animals; D003287:Contrast Media; D005707:Gallic Acid / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D003287:Contrast Media; D011092:Polyethylene Glycols; D005707:Gallic Acid