title: New insights in drug-induced mitochondrial toxicity.
abstract: Drug-induced mitochondrial toxicity is rapidly gaining recognition within the pharmaceutical industry as a contributor to compound attrition and post-market drug withdrawals. This article describes the mechanisms which lead to drug-induced mitochondrial toxicity, discusses high-throughput in vitro assays which are currently being used to identify mitochondrial dysfunction, and provides an overview on some of the drugs which impair mitochondrial function. While considerable progress has been made in the development of high-throughput assays to screen for mitochondrial impairment in vitro, much remains to be done. This includes the development of in silico models to predict drug-induced mitochondrial impairment, wider acceptance of suitable animal models, identification and validation of relevant biomarkers, and the translation of in vitro/in vivo results to clinical outcomes.
authors: Compound Safety Prediction, Pfizer Global R&D, Eastern Point Rd, Groton, CT 06340, USA. sashi.nadanaciva@pfizer.com
authors: Sashi
authors: S
authors: Nadanaciva
authors: Yvonne
authors: Y
authors: Will
mesh_terms: D000818:Animals; D015415:Biomarkers; D004195:Disease Models, Animal; D064420:Drug-Related Side Effects and Adverse Reactions / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D057166:High-Throughput Screening Assays; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000473:pathology / Q000502:physiology
chemical_list: D015415:Biomarkers