title: Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone (naphthylpyrovalerone).
abstract: BACKGROUND
  Naphyrone (naphthylpyrovalerone) is a cathinone derivative and recreational drug related to mephedrone.
  
  
  METHODS
  We report a 31-year-old man who ingested a dose of naphyrone (100 mg), which produced acute sympathomimetic toxicity with restlessness, insomnia, anxiety, and hallucinations lasting for 2 days. Naphyrone was detected in the patient's plasma by gas chromatography with mass spectrometry at concentrations of 0.03 and 0.02 mg/L, 40 and 60 h after drug intake, respectively.
  
  
  CONCLUSIONS
  Based on the present case report and user web-reports, as well as on the chemical structure and pharmacological characteristics, naphyrone produces stimulant-like psychotropic effects and sympathomimetic toxicity.
authors: Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
authors: Adrian
authors: A
authors: Derungs
authors: Simeon
authors: S
authors: Schietzel
authors: Markus R
authors: MR
authors: Meyer
authors: Hans H
authors: HH
authors: Maurer
authors: Stephan
authors: S
authors: Krähenbühl
authors: Matthias E
authors: ME
authors: Liechti
mesh_terms: D000328:Adult; D001007:Anxiety / Q000139:chemically induced; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D013287:Illicit Drugs / Q000506:poisoning*; D008297:Male; D010422:Pentanones / Q000506:poisoning*; D011595:Psychomotor Agitation / Q000209:etiology; D011619:Psychotropic Drugs / Q000506:poisoning*; D011759:Pyrrolidines / Q000506:poisoning*; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology
chemical_list: C509270:1-naphthalen-2-yl-2-pyrrolidin-1-ylpentan-1-one; D013287:Illicit Drugs; D010422:Pentanones; D011619:Psychotropic Drugs; D011759:Pyrrolidines