title: Protective effects of baicalin and quercetin on an iron-overloaded mouse: comparison of liver, kidney and heart tissues.
abstract: Excessive accumulation of iron in the body can lead to organ injury. Some flavonoids which possess high affinity to iron can be used as iron chelators for curing iron overload diseases such as haemochromatosis. In this article, the effects of baicalin and quercetin on different mouse tissues (liver, kidney and heart) afflicted with iron overload-induced injury were studied. It was found that after administration of 500 mg kg⁻¹ iron dextran for 45 days, the degree of oxidative injury in the three organs was different. When iron dextran-induced iron-overloaded mice were fed a diet containing baicalin or quercetin (1% w/w), both flavonoids showed significant effects in suppressing iron overload-induced injury. The efficiencies of both flavonoids on different tissues varied. Both flavonoids caused a significant decrease of iron content in liver and kidney tissues but not in the heart, whereas the flavonoids were more efficient in inhibiting the increase of carbonyl content and the thiobarbituric acid reactive substance levels in heart tissues. The results indicate that the protective effects of baicalin and quercetin on different tissues of iron-overloaded mice are different.
authors: School of Physics and Chemistry, Xihua University, Chengdu 610039, P.R. China.
authors: Yan
authors: Y
authors: Zhang
authors: Zhonghong
authors: Z
authors: Gao
authors: Jiaqin
authors: J
authors: Liu
authors: Zhihong
authors: Z
authors: Xu
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D002374:Catalase / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D007501:Iron / Q000378:metabolism; D019190:Iron Overload / Q000139:chemically induced / Q000473:pathology* / Q000517:prevention & control*; D007505:Iron-Dextran Complex / Q000633:toxicity; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D015394:Molecular Structure; D009929:Organ Size; D010084:Oxidation-Reduction / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D011794:Quercetin / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D005419:Flavonoids; D011506:Proteins; D017392:Thiobarbituric Acid Reactive Substances; C038044:baicalin; D007505:Iron-Dextran Complex; D011794:Quercetin; D007501:Iron; D002374:Catalase