title: Influence of blood viscosity to cerebral blood flow in older humans compared to young subjects.
abstract: OBJECTIVE
  Since blood viscosity (BV) is one of the most important factors determining blood flow, this study aimed to investigate the possible correlation between increased blood viscosity and reduction of regional cerebral blood flow (rCBF) in healthy ageing.
  
  
  METHODS
  Male subjects were distributed in two groups: "young", aged 20-30 (27 volunteers), or "elderly", aged 60-70 (50 volunteers). Whole blood viscosity was obtained with a Wells-Brookfield Cone/Plate Viscometer. Cerebral blood flow was analysed by means of single photon emission computed tomography (SPECT).
  
  
  RESULTS
  The mean BV values were 3.28±0.43 mPa in the group of young volunteers and 4.33±0.73 mPa in the group of elderly volunteers (t=-6.9, p<0.0001). The elderly had a lower blood flow than the young in the following regions: bilateral parietal; temporal-parietal and temporal of the left hemisphere. Pearson's correlation between BV and rCBF showed a good inverse correlation when the BV was above 3.95±0.83 mPa.
  
  
  CONCLUSIONS
  Our results point to a close relationship between the two parameters analysed, BV and rCBF. The impairment in rCBF observed in the elderly volunteers might be due to an increase in BV, among other factors.
  
  
  CONCLUSIONS
  These findings suggest interesting possibilities for the treatment/prevention of brain ageing.
authors: Department of Biosciences, Universidade Estadual Paulista, Rio Claro, SP, Brazil.
authors: Ruth F
authors: RF
authors: Santos-Galduróz
authors: Orlando F A
authors: OF
authors: Bueno
authors: Lilian I
authors: LI
authors: Yamaga
authors: Fernanda
authors: F
authors: Armani
authors: José Carlos F
authors: JC
authors: Galduróz
mesh_terms: D000328:Adult; D000368:Aged; D001809:Blood Viscosity / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D054022:Cerebrum / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology*; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D055815:Young Adult
chemical_list: D019690:Technetium Tc 99m Exametazime