title: Hyperoxia after cardiac arrest may not increase ischemia-reperfusion injury.
abstract: In the last decade, moderate hypothermia has become the mainstay of treatment in the post-resuscitation period. However, for the damaged brain, optimizing oxygen transport, including arterial oxygenation, may also be important. The current view states that hyperoxia in the immediate post-resuscitation period may worsen cerebral outcome, and international guidelines recommend a target arterial oxygen saturation of 94% to 98%. An article in the previous issue of Critical Care challenges this viewpoint. In an elegant study using a Cox proportional hazards model combined with sensitivity analyses and time period matching, the authors show no independent association between hyperoxia and in-hospital mortality. The present commentary discusses these contradictory findings and suggests a practical solution to solve these differences.
authors: Department of Intensive Care, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
authors: Cornelia W
authors: CW
authors: Hoedemaekers
authors: Johannes G
authors: JG
authors: van der Hoeven
mesh_terms: D016887:Cardiopulmonary Resuscitation; D005260:Female; D006323:Heart Arrest / Q000628:therapy*; D017052:Hospital Mortality; D006801:Humans; D018496:Hyperoxia / Q000401:mortality*; D008297:Male