title: Mango modulates body fat and plasma glucose and lipids in mice fed a high-fat diet.
abstract: Consumption of fruits and vegetables has been investigated for their role in the prevention of many chronic conditions. Among the fruits, mango provides numerous bioactive compounds such as carotenoids, vitamin C and phenolic compounds, which have been shown to have antioxidant and anti-inflammatory properties. The present study examined the effects of dietary supplementation of freeze-dried mango pulp, in comparison with the hypolipidaemic drug, fenofibrate, and the hypoglycaemic drug, rosiglitazone, in reducing adiposity and alterations in glucose metabolism and lipid profile in mice fed a high-fat (HF) diet. Male C57BL/6J mice were randomly divided into six treatment groups (eight to nine/group): control (10 % energy from fat); HF (60 % energy from fat); HF+1 or 10 % freeze-dried mango (w/w); HF+fenofibrate (500 mg/kg diet); HF+rosiglitazone (50 mg/kg diet). After 8 weeks of treatment, mice receiving the HF diet had a higher percentage body fat (P = 0·0205) and epididymal fat mass (P = 0·0037) compared with the other treatment groups. Both doses of freeze-dried mango, similar to fenofibrate and rosiglitazone, prevented the increase in epididymal fat mass and the percentage of body fat. Freeze-dried mango supplementation at the 1 % dose improved glucose tolerance as shown by approximately 35 % lower blood glucose area under the curve compared with the HF group. Moreover, freeze-dried mango lowered insulin resistance, as indicated by the homeostasis model assessment of insulin resistance, to a similar extent as rosiglitazone and modulated NEFA. The present findings demonstrate that incorporation of freeze-dried mango in the diet of mice improved glucose tolerance and lipid profile and reduced adiposity associated with a HF diet.
authors: Department of Nutritional Sciences, Oklahoma State University, Stillwater, 422 HES, OK 74078, USA. edralin.a.lucas@okstate.edu
authors: Edralin A
authors: EA
authors: Lucas
authors: Wenjia
authors: W
authors: Li
authors: Sandra K
authors: SK
authors: Peterson
authors: Angela
authors: A
authors: Brown
authors: Solo
authors: S
authors: Kuvibidila
authors: Penny
authors: P
authors: Perkins-Veazie
authors: Stephen L
authors: SL
authors: Clarke
authors: Brenda J
authors: BJ
authors: Smith
mesh_terms: D052242:Adiponectin / Q000097:blood; D050154:Adiposity; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage*; D020869:Gene Expression Profiling; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D031022:Mangifera; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D020738:Leptin; D008055:Lipids