title: EBMT risk score predicts outcome of allogeneic hematopoietic stem cell transplantation in patients who have failed a previous transplantation procedure.
abstract: Increasing numbers of allogeneic hematopoietic stem cell transplantation (allo-SCT) are being performed for patients who have failed a previous allogeneic or autologous SCT. We investigated whether the EBMT risk score could predict outcome after a subsequent allo-SCT. We analyzed prognostic factors in 124 consecutive patients who underwent a second transplantation using an allogeneic donor at our institution. Patients with either a first autologous (N = 64) or first allogeneic (N = 60) SCT were included. Age, disease stage, time interval from diagnosis to transplantation, donor type, and donor-recipient sex combination were used to establish a score from 0 to 7 points, from which 3 groups were identified. The 5-year survival probability decreased from 51.7% for risk scores 0-3 (low, n = 25), to 29.3% for risk score 4 (intermediate, n = 42), and only 10.4% for risk scores 5-7 (high, n = 57), P = .001. We propose that the EBMT risk score can identify patients most likely to benefit from a second transplantation.
authors: Department of Hematology, Imperial College, Hammersmith Hospital, Du Cane Road, London, UK. k.rezvani@imperial.ac.uk
authors: Katayoun
authors: K
authors: Rezvani
authors: Edward J
authors: EJ
authors: Kanfer
authors: David
authors: D
authors: Marin
authors: Ian
authors: I
authors: Gabriel
authors: Amin
authors: A
authors: Rahemtulla
authors: Alexandra
authors: A
authors: Taylor
authors: Donald
authors: D
authors: Macdonald
authors: Francesco
authors: F
authors: Dazzi
authors: Dragana
authors: D
authors: Milojkovic
authors: Letizia
authors: L
authors: Foroni
authors: Jiri
authors: J
authors: Pavlu
authors: Jeremy
authors: J
authors: Sargent
authors: Rifca
authors: R
authors: Le Dieu
authors: John M
authors: JM
authors: Goldman
authors: Jane
authors: J
authors: Apperley
authors: Richard
authors: R
authors: Szydlo
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D019337:Hematologic Neoplasms / Q000401:mortality* / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous