title: Coexistence of osteoporosis (OP) and coronary artery disease (CAD) in the elderly: it is not just a by chance event.
abstract: Cardiovascular disease (CVD) and OP are common age-related conditions. In both cross-sectional and longitudinal epidemiologic studies, low bone mass has been related to increased frequency of CVD. But available data in geriatric population is limited. In this study we aimed to seek the possible relationship between CAD and low bone mineral density (BMD) in a large number of geriatric patients. A total of 2235 patients aged 65 years or more were included in this cross-sectional study. All patients underwent a complete geriatric assessment and evaluated for CAD and cardiovascular risk factors. BMD was measured by dual-energy X-ray absorptiometry at the lumbar spine (L1-L4) and femoral neck. BMD results were classified into three groups; normal (T-score: ≥-1.0×S.D.), osteopenia (T-score between -1.0 and -2.5×S.D.), and OP (T-score: ≤-2.5×S.D.). CAD was present in 397 (29.7%) of 1335 patients with OP, in 199 (27.4%) of 726 patients with osteopenia and in 34 (19.5%) of 174 patients with normal BMD. Multivariate regression analysis revealed that presence of OP or osteopenia increased the prevalence of CAD as an independent correlate (OR=1.643; 95% CI=1.068-2.528, p=0.030). This study highlights the need for careful evaluation of elderly patients with low BMD for possible CAD.
authors: Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Geriatric Medicine, 06100 Sihhiye, Ankara, Turkey. dryyesil@gmail.com
authors: Yusuf
authors: Y
authors: Yesil
authors: Zekeriya
authors: Z
authors: Ulger
authors: Meltem
authors: M
authors: Halil
authors: Burçin
authors: B
authors: Halaçli
authors: Burcu Balam
authors: BB
authors: Yavuz
authors: Nesibe Karahan
authors: NK
authors: Yeşil
authors: Mehmet Emin
authors: ME
authors: Kuyumcu
authors: Mustafa
authors: M
authors: Cankurtaran
authors: Servet
authors: S
authors: Ariogul
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000453:epidemiology; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D015577:Geriatric Assessment / Q000706:statistics & numerical data; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors