title: Treatment of psoriasis with recombinant human LFA3-antibody fusion protein: a multi-center, randomized, double-blind trial in a Chinese population.
abstract: To evaluate clinical efficacy and safety of injectable recombinant human LFA3-antibody fusion protein (rhLFA3-IgFP), a multi-center, randomized, double-blind, double-dummy, parallel-controlled clinical trial was performed in 212 cases of moderate to severe psoriasis. Intramuscular injection of rhLFA3-IgFP (15 mg/week) and oral administration of blank dummy methotrexate at the dose of 7.5 mg/week was performed in the patients in the experimental group, and control patients were orally administered with methotrexate at the dose of 7.5 mg/week and intramuscularly injected with the blank dummy rhLFA3-IgFP (15 mg/week). PASI was determined prior to and at 2, 4, 6, 8, 12, 16, 20 weeks after the treatment. The efficacy evaluation was carried out on 192 patients, and no significant differences were found in PASI50, PASI75 &#38; PASI90 between the two groups after twelve weeks' treatment (p>0.05). After discontinuation, PASI scores continued to decrease drastically in the experiment group, whereas they increased in the control group. At 8 weeks after discontinuation, PASI scores were decreased by 62.32% (p&#60;0.05) and 52.67% (p&#60;0.05) in the experimental and control groups, respectively. No serious adverse reactions were observed. In conclusion, the results of our investigation demonstrated that rhLFA3-IgFP was an effective therapy for chronic plaque psoriasis with lasting action and low incidence of adverse reactions.
authors: Dermatology Department, Third Military Medical University, Chongqing, China.
authors: Heng
authors: H
authors: Yan
authors: Min
authors: M
authors: Tang
authors: Yi
authors: Y
authors: You
authors: Jian-Bin
authors: JB
authors: Yu
authors: Jiang-An
authors: JA
authors: Zhang
authors: Xiao-Hong
authors: XH
authors: Li
authors: Jian-Fang
authors: JF
authors: Sun
authors: Yi-Qun
authors: YQ
authors: Jiang
authors: Hao
authors: H
authors: Chen
authors: Zai-Pei
authors: ZP
authors: Guo
authors: Lin
authors: L
authors: Xiong
authors: Wei
authors: W
authors: He
authors: Zhi
authors: Z
authors: Li
authors: Jun
authors: J
authors: Gu
authors: Chun-Fang
authors: CF
authors: Gao
authors: Zhi-Li
authors: ZL
authors: Guo
authors: Tian-Wen
authors: TW
authors: Gao
authors: Gang
authors: G
authors: Wang
authors: Xian-Ping
authors: XP
authors: Li
authors: Jing
authors: J
authors: Li
authors: Fei
authors: F
authors: Hao
authors: Ya-Jun
authors: YJ
authors: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010147:Pain Measurement; D011565:Psoriasis / Q000188:drug therapy*; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; C540586:LFA3-IgG1 fusion protein, human; D011993:Recombinant Fusion Proteins; D008727:Methotrexate