title: Design of a handheld optical coherence microscopy endoscope.
abstract: Optical coherence microscopy (OCM) combines coherence gating, high numerical aperture optics, and a fiber-core pinhole to provide high axial and lateral resolution with relatively large depth of imaging. We present a handheld rigid OCM endoscope designed for small animal surgical imaging, with a 6-mm diam tip, 1-mm scan width, and 1-mm imaging depth. X-Y scanning is performed distally with mirrors mounted to micro galvonometer scanners incorporated into the endoscope handle. The endoscope optical design consists of scanning doublets, an afocal Hopkins relay lens system, a 0.4 numerical aperture water immersion objective, and a cover glass. This endoscope can resolve laterally a 1.4-μm line pair feature and has an axial resolution (full width half maximum) of 5.4 μm. Images taken with this endoscope of fresh ex-vivo mouse ovaries show structural features, such as corpus luteum, primary follicles, growing follicles, and fallopian tubes. This rigid handheld OCM endoscope can be useful for a variety of minimally invasive and surgical imaging applications.
authors: University of Arizona, College of Optical Sciences, 1630 East University Boulevard, Tucson, Arizona 85721, USA. Vrushali.R.Korde@gmail.com
authors: Vrushali R
authors: VR
authors: Korde
authors: Erica
authors: E
authors: Liebmann
authors: Jennifer K
authors: JK
authors: Barton
mesh_terms: D000818:Animals; D019723:Endoscopes; D004724:Endoscopy / Q000295:instrumentation*; D004867:Equipment Design; D005260:Female; D006652:Histological Techniques; D051379:Mice; D010053:Ovary / Q000033:anatomy & histology / Q000166:cytology; D041623:Tomography, Optical Coherence / Q000295:instrumentation*