title: [Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2009].
abstract: The antibacterial activity of meropenem (MEPM) and other parenteral antibiotics against clinical isolates of 2655 strains including 810 strains of Gram-positive bacteria, 1635 strains of Gram-negative bacteria, and 210 strains of anaerobic bacteria obtained from 30 medical institutions during 2009 was examined. The results were as follows; (1) MEPM was more active than the other carbapenem antibiotics tested against Gram-negative bacteria, especially against enterobacteriaceae and Haemophilus influenzae. MEPM was also active against most of the species tested in Gram-positive and anaerobic bacteria, except for multidrug resistant strains including methicillin-resistant Staphylococcus aureus (MRSA). (2) MEPM maintained potent and stable antibacterial activity against Pseudomonas aeruginosa. The proportion of MEPM-resistant strains to ciprofloxacin-resistant strains or imipenem-resistant strains were 53.1% and 58.0% respectively. (3) The proportion of extended-spectrum beta-lactamase (ESBL) strains was 3.1% (26 strains) in enterobacteriaceae. And the proportion of metallo-beta-lactamase strains was 2.0% (6 strains) in P. aeruginosa. (4) Of all species tested, there were no species except for Bacteroides fragilis group, which MIC90 of MEPM was more than 4-fold higher than those in our previous study. Therefore, there is almost no significant decrease in susceptibility of clinical isolates to meropenem. In conclusion, the results from this surveillance study suggest that MEPM retains its potent and broad antibacterial activity and therefore is a clinically useful carbapenem for serious infections treatment at present, 14 years passed after available for commercial use in Japan.
authors: Department of Microbiology and Infectious Diseases, Toho University School of Medicine.
authors: Keizo
authors: K
authors: Yamaguchi
authors: Yoshikazu
authors: Y
authors: Ishii
authors: Morihiro
authors: M
authors: Iwata
authors: Naoki
authors: N
authors: Watanabe
authors: Masaaki
authors: M
authors: Shinagawa
authors: Minoru
authors: M
authors: Yasujima
authors: Akira
authors: A
authors: Suwabe
authors: Makiko
authors: M
authors: Kuroda
authors: Mitsuo
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authors: Kaku
authors: Miho
authors: M
authors: Kitagawa
authors: Keiji
authors: K
authors: Kanemitsu
authors: Yuji
authors: Y
authors: Imafuku
authors: Masami
authors: M
authors: Murakami
authors: Sachie
authors: S
authors: Yomodu
authors: Nobuyuki
authors: N
authors: Taniguchi
authors: Toshiyuki
authors: T
authors: Yamada
authors: Fumio
authors: F
authors: Nomura
authors: Harushige
authors: H
authors: Kanno
authors: Shiegefumi
authors: S
authors: Maesaki
authors: Giichi
authors: G
authors: Hashikita
authors: Shigemi
authors: S
authors: Kondo
authors: Shigeki
authors: S
authors: Misawa
authors: Hajime
authors: H
authors: Horiuchi
authors: Yoko
authors: Y
authors: Tazawa
authors: Hideki
authors: H
authors: Nakashima
authors: Hiromu
authors: H
authors: Takemura
authors: Masahiko
authors: M
authors: Okada
authors: Yoshinori
authors: Y
authors: Horikawa
authors: Masato
authors: M
authors: Maekawa
authors: Osanori
authors: O
authors: Nagura
authors: Tetsuya
authors: T
authors: Yagi
authors: Hisashi
authors: H
authors: Baba
authors: Shiomi
authors: S
authors: Ishigo
authors: Naohisa
authors: N
authors: Fujita
authors: Toshiaki
authors: T
authors: Komori
authors: Satoshi
authors: S
authors: Ichiyama
authors: Kiyoharu
authors: K
authors: Yamanaka
authors: Yoko
authors: Y
authors: Murata
authors: Shuji
authors: S
authors: Matsuo
authors: Hisashi
authors: H
authors: Kohno
authors: Seiji
authors: S
authors: Kawano
authors: Shohiro
authors: S
authors: Kinoshita
authors: Tomohiko
authors: T
authors: Taminato
authors: Kiyoshi
authors: K
authors: Negayama
authors: Mitsuharu
authors: M
authors: Murase
authors: Hitoshi
authors: H
authors: Miyamoto
authors: Nobuchika
authors: N
authors: Kusano
authors: Motoko
authors: M
authors: Nose
authors: Michiya
authors: M
authors: Yokozaki
authors: Hideyuki
authors: H
authors: Itaha
authors: Akira
authors: A
authors: Matsunaga
authors: Hisae
authors: H
authors: Yoshimura
authors: Shigeru
authors: S
authors: Kohno
authors: Katsunori
authors: K
authors: Yanagihara
authors: Junichi
authors: J
authors: Matsuda
authors: Tetsunori
authors: T
authors: Saikawa
authors: Kazufumi
authors: K
authors: Hiramatsu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004304:Dosage Forms; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D000077731:Meropenem; D008875:Middle Aged; D012137:Respiratory System / Q000382:microbiology; D013845:Thienamycins / Q000494:pharmacology*; D013997:Time Factors; D014556:Urine / Q000382:microbiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004304:Dosage Forms; D013845:Thienamycins; D000077731:Meropenem