title: [Veto T cells enhance engraftment allogeneic hematopoietic stem cells].
abstract: Veto activity was defined as the capacity of specifically downregulating cytotoxic T-precursor cell (CTL-p) directed against antigens of the veto cells themselves but not against third-party antigens. Many studies have shown that the most potent veto cells are CD8(+) cytotoxic T lymphocytes (CD8(+)CTLs). Effectively, CD8(+)CTLs of donor origin can facilitate engraftment of donor's stem cells by eliminating host-alloreactive T lymphocytes. In this article, effect mechanisms, depletion of GVH ex vivo, application in vivo, synergistic enhancement with rapamycin and regulatory T cells, and anti-tumor effect in the hematopoietic stem cell transplantation are summarized.
authors: Department of Hematolgy, Chinese PLA Air Force General Hospital, Beijing 100142, China; The Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
authors: Feng
authors: F
authors: Li
authors: Lian-Ning
authors: LN
authors: Duan
authors: Shu-Quan
authors: SQ
authors: Ji
mesh_terms: D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007108:Immune Tolerance; D013602:T-Lymphocytes, Cytotoxic