title: LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models.
abstract: A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.
authors: Laboratories of Molecular Imaging, Department of Radiology, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA. Yoko.Yamakoshi@uphs.upenn.edu
authors: Yoko
authors: Y
authors: Yamakoshi
authors: Hui
authors: H
authors: Qiao
authors: Andrew N
authors: AN
authors: Lowell
authors: Mark
authors: M
authors: Woods
authors: Betty
authors: B
authors: Paulose
authors: Yuka
authors: Y
authors: Nakao
authors: Hualei
authors: H
authors: Zhang
authors: Ting
authors: T
authors: Liu
authors: Sissel
authors: S
authors: Lund-Katz
authors: Rong
authors: R
authors: Zhou
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D056831:Coordination Complexes / Q000737:chemistry / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D005682:Gadolinium / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D008077:Lipoproteins, LDL / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D018345:Mice, Knockout; D011877:Radionuclide Imaging
chemical_list: C520644:1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid; D003287:Contrast Media; D056831:Coordination Complexes; D006573:Heterocyclic Compounds, 1-Ring; D008077:Lipoproteins, LDL; D005682:Gadolinium