title: Deep vein thrombosis after bunionectomy: a case report of two genetic mutations.
abstract: Deep venous thrombosis after foot and ankle surgery is a serious complication that can have potentially life-threatening complications, such as pulmonary embolus. Genetic mutations have been reported in the published data to cause an increased risk of developing deep vein thrombosis. Two such genetic mutations are the methylenetetrahydrofolate reductase gene variant C677T and the 4G/5G polymorphism of the plasminogen activator inhibitor gene. This case report presents a female patient who developed a postoperative deep vein thrombosis after hallux valgus reconstruction. A hypercoagulable panel revealed the 2 mentioned genetic mutations. We hope this case study will highlight the importance of ascertaining all patient risk factors and the relation to perioperative deep vein thrombosis prophylaxis.
authors: Department of Foot and Ankle Surgery, Western Pennsylvania Hospital, Pittsburgh, PA, USA.
authors: Kyle S
authors: KS
authors: Peterson
authors: Robert W
authors: RW
authors: Mendicino
authors: Alan R
authors: AR
authors: Catanzariti
authors: Karl R
authors: KR
authors: Saltrick
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006215:Hallux Valgus / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D009154:Mutation; D010027:Osteotomy / Q000009:adverse effects* / Q000379:methods; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011859:Radiography; D018570:Risk Assessment; D019851:Thrombophilia / Q000235:genetics* / Q000628:therapy; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D014859:Warfarin