title: [Basaloid squamous carcinoma with a spindle cell component and osseous metaplasia presenting as a polyp of the hypopharynx].
abstract: We report a case of basaloid squamous carcinoma with a spindle cell component of the hypopharynx, in a 61-years-old-man. An excisional biopsy of a pedonculated and polypoid tumour was performed by endoscopy. The histologic examination revealed a biphasic tumour with both a basaloid carcinomatous and a spindle cell component. Focally, osseous metaplasia was seen. The spindle cell component demonstrated immunoreactivity with the p63 epithelial marker. The patient was treated with chemotherapy followed by radiotherapy. The patient has been free of disease for one year. It's the ninth case reported in the literature of a biphasic carcinoma with both a basaloid squamous and a spindle cell component and the first case with osseous metaplasia.
authors: Inserm U858, IFR 150, Équipe 15, laboratoire d'anatomie pathologique et d'histologie-cytologie, université Paul-Sabatier Toulouse III, CHU Rangueil, avenue Jean-Poulhès, 31059 Toulouse cedex 9, France. lavialle-guillotreau.v@chu-toulouse.fr
authors: Virginie
authors: V
authors: Lavialle-Guillotreau
authors: Emmanuelle
authors: E
authors: Uro-Coste
authors: Annie
authors: A
authors: Patelli
authors: Patrick
authors: P
authors: Belvèze
authors: Marie-Bernadette
authors: MB
authors: Delisle
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D015182:Lymphatic Irradiation; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011127:Polyps / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D056144:Pyriform Sinus / Q000473:pathology; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D012907:Smoking / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor