title: Effect of low-dose fenvalerate on semen quality capacitation in adult mice.
abstract: BACKGROUND
  Fenvalerate (FEN) has been demonstrated to be a reproductive toxicant in humans and rodents. However, little is known about whether short-term exposure to low-dose FEN produces reproductive toxicity.
  
  
  METHODS
  We administered FEN (0.009 375, 0.1875, 3.750, or 45.00 mg×kg(-1)×d(-1) by gavage for 30 days) to male ICR mice and compared reproductive toxicity parameters between groups receiving different concentrations of FEN. Reproductive toxicity was evaluated by computer-assisted semen quality analysis (CASA), chlortetracycline (CTC) assay, and histopathology.
  
  
  RESULTS
  The sperm morphology and testis histology of FEN-exposed mice (all doses) were similar to that in controlling mice. Exposure to FEN at a concentration of 0.1875 mg×kg(-1)×d(-1) decreased sperm path straightness (STR) and linearity (LIN) (both P < 0.05), but had no significant impact on average path velocity (VAP), straight line velocity (VSL), curvilinear velocity (VCL), lateral amplitude (ALH), beat cross frequency (BCF), or progressive motility (MOT). FEN reduced the rate of mouse sperm capacitation in a dose-dependent manner.
  
  
  CONCLUSIONS
  The present results demonstrate that exposure to low-dose FEN for 30 days reduces semen quality and sperm capacitation in adult mice.
authors: Laboratory of Reproductive Medicine, Department of Cell Biology and Medical Genetics, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Xiao-Dan
authors: XD
authors: Shi
authors: Huan-Jing
authors: HJ
authors: Bi
authors: He-Ling
authors: HL
authors: Fu
authors: Liang-Yun
authors: LY
authors: Li
authors: De-Kang
authors: DK
authors: Liu
authors: Jian-Min
authors: JM
authors: Li
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009570:Nitriles / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D011722:Pyrethrins / Q000494:pharmacology*; D012661:Semen / Q000187:drug effects; D055101:Semen Analysis; D013081:Sperm Motility / Q000187:drug effects; D013737:Testis / Q000187:drug effects
chemical_list: D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate