title: Clot formation, vascular repair and hematoma resolution after ICH, a coordinating role for thrombin?
abstract: Following intracerebral hemorrhage (ICH) there is a sequential response involving activation of the coagulation cascade/platelet plug formation, vascular repair, upregulation of endogenous defense mechanisms and clot resolution. How these responses are coordinated and modified by different hematoma sizes has received little attention. This paper reviews evidence that thrombin can modulate and may coordinate the components of the endogenous response. This has potential consequences for treatment of ICH with a number of modalities.
authors: Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109-2200, USA. rkeep@umich.edu
authors: Richard F
authors: RF
authors: Keep
authors: G
authors: G
authors: Xi
authors: Y
authors: Y
authors: Hua
authors: J
authors: J
authors: Xiang
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D002543:Cerebral Hemorrhage / Q000378:metabolism* / Q000503:physiopathology*; D006406:Hematoma / Q000503:physiopathology*; D006801:Humans; D013917:Thrombin / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D013917:Thrombin