title: An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study.
abstract: A randomized, double-blind, placebo-controlled study was conducted to evaluate the efficacy of GutGard, an extract of Glycyrrhiza glabra, in patients with functional dyspepsia. The primary outcome variables of the study were the change in the severity symptoms and the global assessment of efficacy. The quality of life was evaluated as a secondary outcome measure. The patients received either placebo or GutGard (75 mg twice daily) for 30 days. Efficacy was evaluated in terms of change in the severity of symptoms (as measured by 7-point Likert scale), the global assessment of efficacy, and the assessment of quality of life using the short-form Nepean Dyspepsia Index. In comparison with placebo, GutGard showed a significant decrease (P ≤ .05) in total symptom scores on day 15 and day 30, respectively. Similarly, GutGard showed marked improvement in the global assessment of efficacy in comparison to the placebo. The GutGard group also showed a significant decrease (P ≤ .05) in the Nepean dyspepsia index on day 15 and 30, respectively, when compared to placebo. GutGard was generally found to be safe and well-tolerated by all patients. GutGard has shown significant efficacy in the management of functional dyspepsia.
authors: Department of Medicine, Srinivasa Diabetic Research Centre, Bangalore 560 050, India.
authors: Kadur Ramamurthy
authors: KR
authors: Raveendra
authors: Jayachandra
authors: Venkatappa
authors: V
authors: Srinivasa
authors: Kadur Raveendra
authors: KR
authors: Sushma
authors: Joseph Joshua
authors: JJ
authors: Allan
authors: Krishnagouda Shankargouda
authors: KS
authors: Goudar
authors: Hebbani Nagarajappa
authors: HN
authors: Shivaprasad
authors: Kudiganti
authors: K
authors: Venkateshwarlu
authors: Periasamy
authors: P
authors: Geetharani
authors: Gopalakrishna
authors: G
authors: Sushma
authors: Amit
authors: A
authors: Agarwal