title: Strawberry anthocyanin and its association with postprandial inflammation and insulin.
abstract: The present study investigates the effect of strawberry antioxidants in beverage form on meal-induced postprandial inflammatory and insulin responses in human subjects. Overweight adults (n 24) consumed a high-carbohydrate, moderate-fat meal (HCFM) accompanied by either a strawberry or a placebo beverage in a cross-over design. Postprandial changes in plasma anthocyanins, their metabolites, insulin, glucose and inflammatory markers were assessed for 6 h. The postprandial concentrations of pelargonidin sulfate and pelargonidin-3-O-glucoside were significantly increased when the strawberry beverage was consumed concurrently with the HCFM compared with the placebo beverage (P < 0·001). The strawberry beverage significantly attenuated the postprandial inflammatory response as measured by high-sensitivity C-reactive protein and IL-6 (P < 0·05) induced by the HCFM. It was also associated with a reduction in postprandial insulin response (P < 0·05). Collectively, these data provide evidence for favourable effects of strawberry antioxidants on postprandial inflammation and insulin sensitivity.
authors: National Center for Food Safety and Technology, Illinois Institute of Technology, Moffet Campus, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
authors: Indika
authors: I
authors: Edirisinghe
authors: Katarzyna
authors: K
authors: Banaszewski
authors: Jack
authors: J
authors: Cappozzo
authors: Krishnankutty
authors: K
authors: Sandhya
authors: Collin L
authors: CL
authors: Ellis
authors: Ravi
authors: R
authors: Tadapaneni
authors: Chulani T
authors: CT
authors: Kappagoda
authors: Britt M
authors: BM
authors: Burton-Freeman
mesh_terms: D000328:Adult; D000872:Anthocyanins / Q000737:chemistry / Q000378:metabolism*; D001628:Beverages; D002097:C-Reactive Protein / Q000378:metabolism; D002140:California; D018592:Cross-Over Studies; D005260:Female; D031985:Fragaria / Q000378:metabolism*; D005960:Glucosides / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000737:chemistry; D018384:Oxidative Stress; D010919:Placebos; D019518:Postprandial Period; D016037:Single-Blind Method; D013431:Sulfates / Q000737:chemistry; D013997:Time Factors
chemical_list: D000872:Anthocyanins; D005960:Glucosides; D007328:Insulin; D015850:Interleukin-6; D016877:Oxidants; D010919:Placebos; D013431:Sulfates; C066957:pelargonidin; C078485:pelargonidin-3-glucoside; D002097:C-Reactive Protein