title: Total skin electron beam therapy for cutaneous T-cell lymphoma: a nationwide cohort study from Denmark.
abstract: BACKGROUND
  Total skin electron beam therapy (TSEBT) is an effective palliative treatment for cutaneous T-cell lymphoma (CTCL). In the present study we reviewed the clinical response to TSEBT in Danish patients with CTCL.
  
  
  METHODS
  This retrospective study included 35 patients with CTCL treated with TSEBT in Denmark from 2001 to 2008 and followed for a median time of 7.6 months (range 3 days-3.7 years). Twenty five patients were treated with high-dose (30 Gy) and 10 patients in a protocol with low-dose (4 Gy) TSEBT.
  
  
  RESULTS
  Patients treated with low-dose therapy had inadequate response to treatment compared to patients treated with high-dose. Consequently the study with low-dose was discontinued and published. In patients treated with high-dose the overall response rate was 100%. Complete response (CR) rate was 68% and CR occurred after a median time of 2.1 months (range 1.8 months-2.0 years). We found no difference in CR rate in patients with T2 (66.7%) and T3 disease (78.6%) (p = 0.64). Following CR 82.4% relapsed at a median time of four months (range 12 days-11.5 months). Relapse-free-survival was similar in patients with T2 and T3 disease (p = 0.77). Progressive disease (PD) was experienced in 28.0% and the median time to PD was 9.0 months (range 4.6-44.3 months). Overall progression-free survival was 95.3%, 72.1% and 64.1% after 0.5-, 1- and 2-years. Effects of initial therapy on TSEBT treatment response and side effects to TSEBT were also analyzed.
  
  
  CONCLUSIONS
  In conclusion, the present study confirms that high-dose TSEBT is an effective, but generally not a curative therapy in the management of CTCL. High-dose treatment yielded significantly better results than low-dose treatment with 4 Gy. TSEBT offers significant palliation in most patients when other skin-directed or systemic treatments have failed.
authors: Department of Dermatology, Aarhus University Hospital, Denmark. lise.lindahl@ki.au.dk
authors: Lise M
authors: LM
authors: Lindahl
authors: Maria R
authors: MR
authors: Kamstrup
authors: Peter M
authors: PM
authors: Petersen
authors: Johan
authors: J
authors: Wirén
authors: Morten
authors: M
authors: Fenger-Grøn
authors: Robert
authors: R
authors: Gniadecki
authors: Lars
authors: L
authors: Iversen
authors: Lena
authors: L
authors: Specht
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003718:Denmark; D004307:Dose-Response Relationship, Radiation; D004583:Electrons / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods; D011882:Radiotherapy, High-Energy / Q000379:methods; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000532:radiotherapy*