title: Methylenetetrahydrofolate reductase (MTHFR) genotype, smoking habit, metastasis and oral cancer in Taiwan.
abstract: The aim of this study was to evaluate the association and interaction of genotypic polymorphism in methylenetetrahydrofolate reductase (MTHFR) with smoking habits and oral cancer in Taiwan. Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed in association with oral cancer risk, and their joint effects with individual smoking habits on oral cancer risk are discussed. In total, 620 oral cancer patients and 620 non-cancer controls in central Taiwan were recruited and genotyped. The MTHFR C677T genotype, but not the A1298C, was differently distributed between the oral cancer and control groups. The T allele of MTHFR C677T was significantly more frequently found in controls than in oral cancer patients. Joint effects of smoking and MTHFR C677T genotype significantly affected oral cancer susceptibility. The MTHFR C677T CT and TT genotypes in association with smoking conferred lower odds ratios of 0.66 and 0.54 (95% confidence interval=0.49-0.82 and 0.39-0.86), respectively. Those patients with MTHFR C677T CT and TT genotypes also had a lower risk of oral cancer metastasis. MTHFR C677T genotype may have joint effects with smoking on oral carcinogenesis, and may be a useful biomarker for prediction and prognosis of oral cancer.
authors: Terry Fox Cancer Research Lab, Department of Otolaryngology, China Medical University Hospital, and Graduate Institute of Clinical Medical Science, China Medical University, 2 Yuh-Der Road, Taichung, 404 Taiwan, ROC.
authors: Chia-Wen
authors: CW
authors: Tsai
authors: Chia-Fang
authors: CF
authors: Hsu
authors: Ming-Hsui
authors: MH
authors: Tsai
authors: Yung-An
authors: YA
authors: Tsou
authors: Chun-Hung
authors: CH
authors: Hua
authors: Wen-Shin
authors: WS
authors: Chang
authors: Cheng-Chieh
authors: CC
authors: Lin
authors: Da-Tian
authors: DT
authors: Bau
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D009362:Neoplasm Metastasis; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D013624:Taiwan
chemical_list: D014408:Biomarkers, Tumor; D042965:Methylenetetrahydrofolate Reductase (NADPH2)