title: Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility.
abstract: BACKGROUND
  The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer.
  
  
  RESULTS
  Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote.
  
  
  CONCLUSIONS
  The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.
authors: Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors: Ming-Hsien
authors: MH
authors: Chien
authors: Chung-Han
authors: CH
authors: Hsin
authors: Lin Shih-Shen
authors: LS
authors: Chou
authors: Tsung-Te
authors: TT
authors: Chung
authors: Chien-Huang
authors: CH
authors: Lin
authors: Meng-Shih
authors: MS
authors: Weng
authors: Ming-Yung
authors: MY
authors: Chou
authors: Mu-Kuan
authors: MK
authors: Chen
authors: Shun-Fa
authors: SF
authors: Yang
mesh_terms: D000328:Adult; D017677:Age Distribution; D016022:Case-Control Studies; D016001:Confidence Intervals; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D015999:Multivariate Analysis; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D018123:Receptors, Interleukin / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D013624:Taiwan / Q000453:epidemiology
chemical_list: D004273:DNA, Neoplasm; C515500:IL23R protein, human; D018123:Receptors, Interleukin