title: Inflammatory polyps following successful HLA-matched cord blood transplantation in a patient with X-linked lymphoproliferative syndrome.
abstract: Gastrointestinal complications following HSCT are numerous and include a variety of issues resulting in hepatic, biliary, pancreatic, and intestinal compromise. In the context of an underlying state of immune dysregulation, novel complications may arise including autoimmunity. To our knowledge, this is the first report of a patient with XLP who was successfully treated with HSCT using an HLA-matched unrelated cord blood unit that was complicated by the development of inflammatory polyps of the colon. Given the underlying diagnosis of XLP and its associated immune dysregulation, the challenge of understanding unique gastrointestinal manifestations of autoimmunity following HSCT is discussed.
authors: Divisions of Hematology, CHOC Children's Hospital, Orange, CA 92868, USA. dbuchbinder@choc.org
authors: David
authors: D
authors: Buchbinder
authors: Bassam
authors: B
authors: Younes
authors: Aaron
authors: A
authors: Sassoon
authors: Amit
authors: A
authors: Soni
authors: Loan
authors: L
authors: Hsieh
authors: Geetha
authors: G
authors: Puthenveetil
authors: Jill
authors: J
authors: Stites
authors: Tristen
authors: T
authors: Ness-Jorden
authors: Steven
authors: S
authors: Neudorf
authors: Diane
authors: D
authors: Nugent
mesh_terms: D003111:Colonic Polyps / Q000175:diagnosis* / Q000209:etiology; D036101:Cord Blood Stem Cell Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008232:Lymphoproliferative Disorders / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis*