title: Clinicopathological characteristics of ovarian carcinomas associated with endometriosis.
abstract: BACKGROUND
  Substantial histopathology data provide evidence that endometriosis might be viewed as a precursor lesion of endometrioid and clear cell carcinoma of the ovary, via intermediary atypical borderline lesions. Also, genes involved in both endometriosis and epithelial ovarian cancer have been shown to play a role in the pathogenesis of endometriosis-associated ovarian carcinoma.
  
  
  METHODS
  A retrospective study of 17 cases of ovarian carcinomas associated with endometriosis, diagnosed between 2000 and 2009, at Aretaieion Hospital of University of Athens, is presented. 10/17 cases in this study (58.8%) were clear cell carcinomas (CCC), 6/17 cases (35.3%) were endometrioid adenocarcinomas (EAC) and 1/17 cases (5.9%) was a serous carcinoma associated with ovarian endometriosis. Patients's age was 27-76 years (mean age 58 years). Typical ovarian endometriosis was documented in 8/17 (47%) of the tumors. In 9/17 cases, areas of fibrosis or cystic lesions infiltrated by iron-laden macrophages and endometrial-like stroma, consistent with endometriosis, were observed.
  
  
  CONCLUSIONS
  In comparison with common epithelial ovarian cancers, CCC and EACs of the ovary were presented at earlier stages. Cytoreductive surgical treatment is critical in order to plan appropriate post-operative management.
authors: Pathology Laboratory, University of Athens, Athens, Greece.
authors: A
authors: A
authors: Kondi-Pafiti
authors: E
authors: E
authors: Papakonstantinou
authors: C
authors: C
authors: Iavazzo
authors: C
authors: C
authors: Grigoriadis
authors: N
authors: N
authors: Salakos
authors: O
authors: O
authors: Gregoriou
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D018269:Carcinoma, Endometrioid / Q000150:complications / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D004715:Endometriosis / Q000150:complications*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D010052:Ovariectomy; D017239:Paclitaxel / Q000008:administration & dosage; D012189:Retrospective Studies; D058994:Salpingectomy
chemical_list: D016190:Carboplatin; D017239:Paclitaxel