title: Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
abstract: Sulfuretin is one of major constituents of Rhus verniciflua that exerts anti-inflammatory activities. Some of aurones were synthesized as sulfuretin derivatives and evaluated for their abilities to inhibit NO and PGE(2) production in LPS-induced RAW 264.7 cells in order to reveal the relationship. Of the aurones synthesized in the present study, 2h and 2i, which possess C-6 hydroxyl group in A-ring and methoxy substituents in B-ring, more potently inhibited NO and PGE(2) production and were less cytotoxic than sulfuretin.
authors: Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
authors: Seo Young
authors: SY
authors: Shin
authors: Min Cheol
authors: MC
authors: Shin
authors: Ji-Sun
authors: JS
authors: Shin
authors: Kyung-Tae
authors: KT
authors: Lee
authors: Yong Sup
authors: YS
authors: Lee
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D015232:Dinoprostone / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D001572:Benzofurans; D008070:Lipopolysaccharides; C486837:aurone; D009569:Nitric Oxide; D015232:Dinoprostone