title: Proanthocyanidins inhibit iron absorption from soybean (Glycine max) seed ferritin in rats with iron deficiency anemia.
abstract: The objective of this study was to evaluate the effect of proanthocyanidins (PAs) on iron uptake from soybean seed ferritin (SSF) crude by rats with iron deficiency anemia (IDA) for the first time. Six groups of Sprague-Dawley (SD) rats (n = 10) were used, which contain (1) SSF crude group; (2) SSF crude + PAs group; (3) PAs group; (4) FeSO(4) group; (5) iron deficiency control group; and (6) control group. The bioavailability of iron was examined by measuring hemoglobin (Hb) concentration value, red blood cell (RBC) numbers, and serum iron stores. After 8 weeks, Hb concentration was almost recovered to the normal level upon feeding SSF crude or FeSO(4) to rats. In contrast, Hb concentration was recovered to less extent when SSF crude plus PAs was used instead of SSF crude alone (P < 0.05). A similar profile was observed with these three sample groups when serum iron and RBC were used as parameters. All rats in PAs group died at the 8th week. Taken together, all these results demonstrated that PAs inhibited iron uptake of rats from SSF, and are toxic for rats with IDA.
authors: CAU & ACC Joint-Laboratory of Space Food, College of Food Science and Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of Education, Beijing, People's Republic of China.
authors: Shaojun
authors: S
authors: Yun
authors: Tuo
authors: T
authors: Zhang
authors: Meiliang
authors: M
authors: Li
authors: Bin
authors: B
authors: Chen
authors: Guanghua
authors: G
authors: Zhao
mesh_terms: D000042:Absorption; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001682:Biological Availability; D004912:Erythrocytes / Q000187:drug effects; D005293:Ferritins / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D007501:Iron / Q000097:blood / Q000493:pharmacokinetics*; D058085:Iron Compounds / Q000494:pharmacology; D000090463:Iron Deficiencies; D010936:Plant Extracts / Q000494:pharmacology*; D010940:Plant Proteins / Q000378:metabolism; D044945:Proanthocyanidins / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max
chemical_list: D006454:Hemoglobins; D058085:Iron Compounds; D010936:Plant Extracts; D010940:Plant Proteins; D044945:Proanthocyanidins; D005293:Ferritins; D007501:Iron