title: Synthesis of cyanopyridine and pyrimidine analogues as new anti-inflammatory and antimicrobial agents.
abstract: A new series of substituted benzylidene acetophenone (Ia-Ih), 2-amino-4, 6- substituted diphenylpyridine-3-carbonitrile (IIa-IIh) and 4, 6-substituted diphenylpyrimidin-2-amine (IIId-IIIg) were synthesized and evaluated for anti-inflammatory and antimicrobial activities. Four compounds (Ie, If, IIh and IIId) have shown good anti-inflammatory activity when compared to standard drug indomethacin. Two compound (Ie and IIh) displayed significant activity against gram -ve bacteria (E. Coli) and three compounds (IId, IIf and IIIh) displayed good activity against gram +ve bacteria (S. aureus) on comparison with the standard drug ofloxacin.
authors: Pharmaceutical Chemistry Research Lab., D/o Pharmaceutical Technology, MIET, NH-58, Bypass Road, Baghpat Crossing, Meerut 250005, UP, India. nitinvermakr@gmail.com
authors: Nitin
authors: N
authors: Kumar
authors: Alka
authors: A
authors: Chauhan
authors: Sushma
authors: S
authors: Drabu
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002599:Chalcone / Q000138:chemical synthesis / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests / Q000379:methods; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D009570:Nitriles; D011725:Pyridines; D011743:Pyrimidines; D002599:Chalcone