title: Effect of heat-inactivated kefir-isolated Lactobacillus kefiranofaciens M1 on preventing an allergic airway response in mice.
abstract: In this study, we assessed the anti-asthmatic effects of heat-inactivated Lactobacillus kefiranofaciens M1 (HI-M1) and its fermented milk using different feeding procedures and at various dosage levels. The possible mechanisms whereby HI-M1 has anti-allergic asthmatic effects were also evaluated. Ovalbumin (OVA)-allergic asthma mice that have been orally administrated the HI-M1 samples showed strong inhibition of production of T helper cell (Th) 2 cytokines, pro-inflammatory cytokines, and Th17 cytokines in splenocytes and bronchoalveolar fluid compared to control mice. An increase in regulatory T cell population in splenocytes in the allergic asthma mice after oral administration of H1-M1 was also observed. In addition, all of the features of the asthmatic phenotype, including specific IgE production, airway inflammation, and development of airway hyperresponsiveness, were depressed in a dose-dependent manner by treatment. These findings support the possibility that oral feeding of H1-M1 may be an effective way of alleviating asthmatic symptoms in humans.
authors: Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan, Republic of China.
authors: Wei-Sheng
authors: WS
authors: Hong
authors: Yen-Po
authors: YP
authors: Chen
authors: Ting-Yeu
authors: TY
authors: Dai
authors: I-Nung
authors: IN
authors: Huang
authors: Ming-Ju
authors: MJ
authors: Chen
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000517:prevention & control*; D043302:Cultured Milk Products / Q000382:microbiology*; D005260:Female; D006358:Hot Temperature; D007778:Lactobacillus; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000485:Allergens