title: Novel HLA class I and II alleles identified during routine registry typing in 2010.
abstract: Twenty-one novel human leukocyte antigen (HLA) class I and class II alleles are described: seven HLA-A alleles, five HLA-C alleles, five HLA-B alleles and four HLA-DRB1 alleles. Seventeen (∼81%) of the 21 novel alleles are single nucleotide substitution variants when compared with their most homologous allele. Nine of these single nucleotide variants cause an amino acid substitution, while eight are silent substitutions. The remaining novel alleles differ from their most similar allele by two to three nucleotide substitutions. One novel HLA-C locus allele encodes an amino acid change at codon 10 that previously has not been reported to be polymorphic for this locus. Some of the new alleles encode novel codons and unique amino acid changes at polymorphic positions in the HLA-A (codons 24 and 156) and HLA-B (codons 40 and 115) loci.
authors: Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20057, USA.
authors: A M
authors: AM
authors: Lazaro
authors: Y
authors: Y
authors: Xiao
authors: C
authors: C
authors: Masaberg
authors: W Y K
authors: WY
authors: Hwang
authors: A E J
authors: AE
authors: Yeoh
authors: Y
authors: Y
authors: Weiyan
authors: J
authors: J
authors: Ng
authors: C K
authors: CK
authors: Hurley
authors: P E
authors: PE
authors: Posch
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D005260:Female; D056426:Genetic Loci / Q000502:physiology; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D012042:Registries
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D059811:HLA-DRB1 Chains