title: Simple but powerful: phenanthroline-based small molecules for cellular imaging and cancer screening.
abstract: A two-step synthetic procedure gives highly fluorescent phenanthroline molecular probes. The compounds localize in the endoplasmic reticulum and their potential as bioactive probes was evaluated. The materials are quickly taken up by living cells within 5 min. Preliminary in vitro studies have shown that these compounds are selective to esophageal cancer cells and can be used as selective markers in intracellular cancer diagnostics. The materials show a remarkable cytotoxicity towards cancer cells vs normal as 7-1.
authors: Medicinal Chemistry, Institute of Molecular Medicine, Trinity College Dublin, St. James's Hospital, Dublin 8, Ireland. sengem@tcd.ie
authors: Natalia N
authors: NN
authors: Sergeeva
authors: Marion
authors: M
authors: Donnier-Marechal
authors: Gisela M
authors: GM
authors: Vaz
authors: Anthony M
authors: AM
authors: Davies
authors: Mathias O
authors: MO
authors: Senge
mesh_terms: D045744:Cell Line, Tumor; D004721:Endoplasmic Reticulum / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D018613:Microscopy, Confocal; D010618:Phenanthrolines / Q000737:chemistry* / Q000633:toxicity
chemical_list: D005456:Fluorescent Dyes; D010618:Phenanthrolines