title: [Increased oxidized LDL cholesterol levels in peritoneal fluid of women with advanced-stage endometriosis].
abstract: BACKGROUND
  Proinflammatory and prooxidative environment in the peritoneal cavity may be involved in the pathogenesis of endometriosis. Imbalance between reactive oxygen species levels and the antioxidant capacity leads to oxidation of low-density lipoproteins (LDL). The importance of oxidized LDL (Ox-LDL) in the development of atherosclerosis is well recognized.
  
  
  OBJECTIVE
  The aim of our study was to evaluate for the presence of ox-LDL in the peritoneal fluid (PF) of women with and without endometriosis.
  
  
  METHODS
  A total of 60 women who underwent laparoscopy were divided into groups: endometriosis sufferers with minimal to mild (n 20) and moderate to severe (n 20) stages, and the reference group (n 20) with functional follicle ovarian cysts. Oxidized LDL levels were determined in the PF using enzyme immunoassay
  
  
  RESULTS
  Oxidized LDL levels were detectable in all peritoneal fluid samples. Significantly increased levels of ox-LDL were observed in PF of women with stage III/IV endometriosis compared to the reference group (p = 0.03). However peritoneal fluid ox-LDL concentrations did not differ significantly between patients with minimal/mild and women with moderate/severe stage of the disease (p = 0.2). No significant difference in the PF ox-LDL concentrations was also found between women with stage I/II endometriosis and patients with follicle cysts (p = 0.3).
  
  
  CONCLUSIONS
  Increased peritoneal fluid ox-LDL levels observed in women with advanced-stage endometriosis suggest the important role of oxidative stress in the pathogenesis of the disease.
authors: I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii Uniwersytetu Medycznego w Lublinie, Polska. polakg@yahoo.com
authors: Grzegorz
authors: G
authors: Polak
authors: Diana
authors: D
authors: Mazurek
authors: Ewelina
authors: E
authors: Rogala
authors: Aldona
authors: A
authors: Nowicka
authors: Magdalena
authors: M
authors: Derewianka-Polak
authors: Jan
authors: J
authors: Kotarski
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000032:analysis*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010537:Peritoneum / Q000378:metabolism; D011044:Poland; D011237:Predictive Value of Tests; D012720:Severity of Illness Index
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein