title: Influence of treatment for disruptive behavior disorders on adrenal and gonadal hormones in youth.
abstract: The study examined whether psychosocial intervention for children diagnosed with a disruptive behavior disorder (DBD; n = 84) changed concentrations of cortisol and testosterone across a 3-year follow-up when compared to a matched, nonclinical, healthy comparison (HC; n = 69) group. Boys and girls (6-11 years) with a DBD were randomly assigned to one of two arms of a multimethod intervention. Hierarchical linear modeling revealed that children undergoing psychosocial intervention for a DBD experienced a significant decline in diurnal cortisol change over time (p < .05) when compared to the HC condition. Boys with a DBD diagnosis had significantly lower mean cortisol concentrations prior to treatment (p < .05) and showed a significantly steeper increase in mean cortisol over time (p < .05) when compared to HC boys. Treatment effects for diurnal cortisol change were replicated in the boys-only analysis. No treatment effects were noted for testosterone in either analysis.
authors: Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, OH 45229, USA. lorah.dorn@cchmc.org
authors: Lorah D
authors: LD
authors: Dorn
authors: David J
authors: DJ
authors: Kolko
authors: Chad E
authors: CE
authors: Shenk
authors: Elizabeth J
authors: EJ
authors: Susman
authors: Oscar
authors: O
authors: Bukstein
mesh_terms: D019958:Attention Deficit and Disruptive Behavior Disorders / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D002648:Child; D002940:Circadian Rhythm; D015928:Cognitive Behavioral Therapy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D008297:Male; D011569:Psychiatric Status Rating Scales; D012463:Saliva / Q000737:chemistry; D013739:Testosterone / Q000032:analysis*; D016896:Treatment Outcome
chemical_list: D013739:Testosterone; D006854:Hydrocortisone