title: The influence of mTOR on T helper cell differentiation and dendritic cell function.
abstract: The mammalian target of rapamycin (mTOR) integrates signalling responses to growth factors and nutrients. The macrolide rapamycin inhibits mTOR function and has been used extensively to demonstrate a critical role for mTOR in immune responses. This mini-review summarizes recent evidence demonstrating an integral role for mTOR in the differentiation of T helper cell subsets and the development, maturation and antigen-presenting capacity of DCs in both mice and humans.
authors: College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors: Robert J
authors: RJ
authors: Salmond
authors: Rose
authors: R
authors: Zamoyska
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D051379:Mice; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000276:immunology* / Q000378:metabolism
chemical_list: D058570:TOR Serine-Threonine Kinases