title: Hematologic parameters and angiographic progression of coronary atherosclerosis.
abstract: Hematologic parameters have prognostic importance in cardiovascular disease. However, the relation between atherosclerosis progression and hematologic parameters is not well defined. A total of 394 patients requiring repeat coronary angiography were included in the study. According to angiography, patients were divided into 2 groups, progressive (n = 196) and nonprogressive (n = 198) diseases. Hematologic parameters including mean platelet volume (MPV) and neutrophil/lymphocyte (N/L) ratio were measured. Glucose, creatinine, and cholesterol were significantly higher in the progressive group. Mean platelet volume count was similar in both groups. The N/L ratio was significantly higher in the progressive group (5.0 ± 5.1 vs 3.2 ± 3; P = .001). In multivariate analysis, the N/L ratio was significantly related with progression (relative risk [RR]: 2.267, 95% CI: 1.068-4.815, P = .03). Progression rate was significantly high in patients with high N/L ratio (39% vs 56%). Our results suggest that the N/L ratio is a predictor of progression of atherosclerosis.
authors: Department of Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey. nihatkalay@hotmail.com
authors: Nihat
authors: N
authors: Kalay
authors: Orhan
authors: O
authors: Dogdu
authors: Fatih
authors: F
authors: Koc
authors: Mikail
authors: M
authors: Yarlioglues
authors: Idris
authors: I
authors: Ardic
authors: Mahmut
authors: M
authors: Akpek
authors: Davran
authors: D
authors: Cicek
authors: Abdurrahman
authors: A
authors: Oguzhan
authors: Ali
authors: A
authors: Ergin
authors: Mehmet G
authors: MG
authors: Kaya
mesh_terms: D000368:Aged; D001772:Blood Cell Count; D015331:Cohort Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging* / Q000473:pathology; D018450:Disease Progression; D004909:Erythrocyte Indices; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: D006454:Hemoglobins