title: The role of Factor V Leiden in adult patients with venous thromboembolism: a meta-analysis of published studies from Turkey.
abstract: Factor V Leiden (FVL) is the most common inherited risk factor for venous thromboembolism (VTE). The frequency of FVL in patients with VTE has been reported from different parts of Turkey. A meta-analysis was performed to estimate the risk of VTE associated with FVL in Turkish population. Published studies were retrieved from Pubmed and Science Citation Index/Expanded. We selected studies comparing the prevalence of FVL in patients with VTE with controls. The analysis was performed by the software comprehensive meta-analysis. The analysis consisted of 10 studies including 1202 patients with VTE and 1283 controls. The pooled frequency of FVL was significantly higher in patients with VTE (22.8%) than controls (7.6%). The pooled odds ratio (OR) was 3.4 (95% confidence interval [CI], 2.6-4.5). The study showed homogeneity (Q value, 9.955). No publication bias was observed in any comparison model. Our meta-analysis showed an association of FVL with VTE in Turkey.
authors: General Surgery, Ankara University Medical School, Ankara, Turkey. aydaneroglu@hotmail.com
authors: Aydan
authors: A
authors: Eroglu
authors: Durdu
authors: D
authors: Sertkaya
authors: Nejat
authors: N
authors: Akar
mesh_terms: D005165:Factor V; D005260:Female; D006801:Humans; D008297:Male; D039781:PubMed; D012307:Risk Factors; D013923:Thromboembolism / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D014421:Turkey / Q000453:epidemiology
chemical_list: C095381:factor V Leiden; D005165:Factor V