title: Preliminary results of fractionated stereotactic radiotherapy after cyst drainage for craniopharyngioma in adults.
abstract: OBJECTIVE
  To retrospectively evaluate the effectiveness of fractionated stereotactic radiotherapy (FSRT) for craniopharyngioma.
  
  
  METHODS
  Between 1999 and 2005, 16 patients with craniopharyngioma were referred to Tokyo Medical University Hospital. They received FSRT alone after histologic confirmation by needle biopsy and underwent cyst drainage via endoscopy. The median prescription dose fraction was 30 Gy in six fractions. All patients except 1 were followed up until December 2009 or death.
  
  
  RESULTS
  The median follow-up period was 52 months (range, 4-117 months). Of the 17 patients, 3 experienced recurrence 4 to 71 months after FSRT. The 3-year local control rate was 82.4%. One patient died of thyroid cancer, and the 3-year survival rate was 94.1%. Eight patients had improved visual fields at a median of 2.5 months after FSRT, but hormonal functions did not improve in any patient.
  
  
  CONCLUSIONS
  FSRT after cyst drainage seems to be safe and effective for patients with craniopharyngiomas, and it may be a safe alternative to surgery.
authors: Department of Radiology, Tokyo Medical University Hospital, Tokyo, Japan. kaneka@tokyo-med.ac.jp
authors: Naoto
authors: N
authors: Kanesaka
authors: Ryuji
authors: R
authors: Mikami
authors: Hidetsugu
authors: H
authors: Nakayama
authors: Sachika
authors: S
authors: Nogi
authors: Yu
authors: Y
authors: Tajima
authors: Nobuyuki
authors: N
authors: Nakajima
authors: Jun
authors: J
authors: Wada
authors: Tamotsu
authors: T
authors: Miki
authors: Jou
authors: J
authors: Haraoka
authors: Mitsuru
authors: M
authors: Okubo
authors: Shinji
authors: S
authors: Sugahara
authors: Koichi
authors: K
authors: Tokuuye
mesh_terms: D000328:Adult; D000368:Aged; D003397:Craniopharyngioma / Q000401:mortality / Q000601:surgery*; D003560:Cysts / Q000401:mortality / Q000601:surgery*; D019583:Dose Fractionation, Radiation; D004322:Drainage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate; D014794:Visual Fields; D055815:Young Adult