title: Diffuse large B cell lymphoma complicating total knee arthroplasty: case report and literature review of the association of diffuse large B cell lymphoma with joint replacement.
abstract: Primary lymphoma of bone is extremely rare. There are increasing reports of lymphoma arising in bone adjacent to metallic prostheses. Herein, we describe the case of a 76-year-old man who developed diffuse large B cell lymphoma in the tibia 3 years after total knee arthroplasty for osteoarthritis. A review of the literature has identified 11 other cases of lymphoma arising in the context of orthopaedic metallic implants. To our knowledge this is the first reported case of a primary lymphoma arising in bone adjacent to a knee prosthesis. Possible pathogenetic mechanisms may include chronic antigenic stimulation of lymphocytes, proliferation of EBV-infected B lymphocytes, and direct mutagenic effects of metallic ions. Further research is required to investigate this intriguing link between metallic orthopaedic prostheses and localized lymphoma.
authors: Department of Haematology, Hammersmith Hospital, London, UK. suhailc1000@hotmail.com
authors: Mohammed Suhail
authors: MS
authors: Chaudhry
authors: Harriet
authors: H
authors: Mather
authors: Alexandra
authors: A
authors: Marks
authors: Kikkeri
authors: K
authors: Naresh
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D001859:Bone Neoplasms / Q000601:surgery*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000601:surgery*; D008297:Male; D049268:Positron-Emission Tomography