title: Toward an early marker of metabolic dysfunction: omentin-1 in prepubertal children.
abstract: Omentin-1 is a recently recognized adipokine primarily originating in visceral adipose tissue. We posited that circulating omentin-1 could be an early marker of metabolic dysfunction. To this end, we examined the associations between circulating omentin-1, body fat (bioelectric impedance), an endocrine-metabolic profile (homeostasis model assessment for insulin resistance (HOMA(IR)), serum lipids, high-molecular-weight (HMW) adiponectin and blood pressure (BP)) and family history of obesity and diabetes in asymptomatic prepubertal children (n = 161; 77 boys and 84 girls; age 7 ± 1 year) with a normal distribution of height and weight. Increased circulating omentin-1 was associated with a poorer metabolic profile, with relatively higher HOMA(IR), fasting triacylglycerol, BP and familial prevalence of diabetes (all P < 0.005 to P < 0.0001), and relatively lower fraction of HMW adiponectin (P < 0.005), whereas no relationship was found with body weight or fat or with family history of obesity. All these associations were independent of age, gender and fat mass. In conclusion, circulating omentin-1 may become a marker of metabolic dysfunction integrating insulin sensitivity, markers of adipose-tissue metabolism and BP as early as in prepubertal childhood.
authors: Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain.
authors: Anna
authors: A
authors: Prats-Puig
authors: Judit
authors: J
authors: Bassols
authors: Eva
authors: E
authors: Bargalló
authors: Marta
authors: M
authors: Mas-Parareda
authors: Rosa
authors: R
authors: Ribot
authors: Pilar
authors: P
authors: Soriano-Rodríguez
authors: Àngela
authors: À
authors: Berengüí
authors: Marta
authors: M
authors: Díaz
authors: Francis
authors: F
authors: de Zegher
authors: Lourdes
authors: L
authors: Ibánez
authors: Abel
authors: A
authors: López-Bermejo
mesh_terms: D000273:Adipose Tissue / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology; D050154:Adiposity; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D042241:Early Diagnosis; D017097:Electric Impedance; D005192:Family Health; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D015228:Hypertriglyceridemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D015995:Prevalence; D013030:Spain / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins