title: Grape seed polyphenolic extract specifically decreases aβ*56 in the brains of Tg2576 mice.
abstract: Amyloid-β (Aβ) oligomers, found in the brains of Alzheimer's disease (AD) patients and transgenic mouse models of AD, cause synaptotoxicity and memory impairment. Grape seed polyphenolic extract (GSPE) inhibits Aβ oligomerization in vitro and attenuates cognitive impairment and AD-related neuropathology in the brains of transgenic mice. In the current study, GSPE was administered to Tg2576 mice for a period of five months. Treatment significantly decreased brain levels of Aβ*56, a 56-kDa Aβ oligomer previously shown to induce memory dysfunction in rodents, without changing the levels of transgenic amyloid-β protein precursor, monomeric Aβ, or other Aβ oligomers. These results thus provide the first demonstration that a safe and affordable intervention can lower the levels of a memory-impairing Aβ oligomer in vivo and strongly suggest that GSPE should be further tested as a potential prevention and/or therapy for AD.
authors: N. Bud Grossman Center for Memory Research and Care, University of Minnesota Medical School, Minneapolis, MN, USA.
authors: Peng
authors: P
authors: Liu
authors: Lisa J
authors: LJ
authors: Kemper
authors: Jun
authors: J
authors: Wang
authors: Kathleen R
authors: KR
authors: Zahs
authors: Karen H
authors: KH
authors: Ashe
authors: Giulio M
authors: GM
authors: Pasinetti
mesh_terms: D016229:Amyloid beta-Peptides / Q000096:biosynthesis* / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D015153:Blotting, Western; D001923:Brain Chemistry / Q000187:drug effects*; D019281:Dimerization; D056604:Grape Seed Extract / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D047468:Immunoprecipitation; D018782:Maze Learning; D051379:Mice; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000378:metabolism; D059808:Polyphenols / Q000494:pharmacology*; D011489:Protein Denaturation; D012639:Seeds / Q000737:chemistry; D027843:Vitis / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D056604:Grape Seed Extract; D009419:Nerve Tissue Proteins; D059808:Polyphenols