title: Negative feedback and physical limits of genes.
abstract: This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in terms of response time and output noise under the assumption of fixed metabolic cost. The analysis shows that, in the case of non-vanishing leak expression rate, the negative feedback reduces both the switching on and switching off times of a gene. The noise of the auto-repressed gene will be lower than the one of the simple gene only for low leak expression rates. Summing up, for low, but non-vanishing leak expression rates, the auto-repressed gene is both faster and less noisier compared to the simple one.
authors: School of Computing, University of Kent, Canterbury, UK. n.r.zabet@gen.cam.ac.uk
authors: Nicolae Radu
authors: NR
authors: Zabet
mesh_terms: D025461:Feedback, Physiological / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006706:Homeostasis / Q000235:genetics; D008957:Models, Genetic; D014176:Protein Biosynthesis / Q000235:genetics; D011506:Proteins / Q000378:metabolism; D011930:Reaction Time / Q000235:genetics
chemical_list: D011506:Proteins