title: Surface acoustic waves increase the susceptibility of Pseudomonas aeruginosa biofilms to antibiotic treatment.
abstract: Bacterial urinary tract infections resulting from prolonged patient catheterization have become a major health problem. One of the major issues is bacterial resistance to antibiotic treatments due to biofilm formation inside the catheters, thus enhancing the search for alternative treatments. In the present study, a device containing a piezo element capable of transmitting low-frequency surface acoustic waves (SAW) onto the indwelling catheter was used. The SAW were able to eradicate biofilm-residing bacteria by >85% when applied simultaneously with an antibiotic in three clinically relevant species, viz. Escherichia coli, Staphylococcus epidermidis and Pseudomonas aeruginosa. Moreover, transcriptome analysis revealed that SAW can alter the transcription pattern of P. aeruginosa, suggesting that this signal can be specifically sensed by the bacterium.
authors: The Institute for Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, 52900, Israel.
authors: Moran
authors: M
authors: Kopel
authors: Elena
authors: E
authors: Degtyar
authors: Ehud
authors: E
authors: Banin
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002408:Catheters, Indwelling / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D013016:Sound; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000254:growth & development; D014732:Vibration
chemical_list: D000900:Anti-Bacterial Agents