title: Copper(I)-catalyzed cycloaddition of silver acetylides and azides: incorporation of volatile acetylenes into the triazole core.
abstract: Silver acetylides and organic azides react under copper(I) catalysis to afford 1,4-disubstituted 1,2,3-triazoles. Mechanistic studies implicate a process involving transmetallation to copper acetylides prior to cycloaddition. This work demonstrates that silver acetylides serve as suitable precursors for entry into copper-mediated coupling reactions. This methodology allows the incorporation of volatile and difficult-to-handle acetylenes into the triazole core.
authors: School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.
authors: Ilaria
authors: I
authors: Proietti Silvestri
authors: Fikre
authors: F
authors: Andemarian
authors: George N
authors: GN
authors: Khairallah
authors: Su Wan
authors: SW
authors: Yap
authors: Tim
authors: T
authors: Quach
authors: Sammi
authors: S
authors: Tsegay
authors: Craig M
authors: CM
authors: Williams
authors: Richard A J
authors: RA
authors: O'Hair
authors: Paul S
authors: PS
authors: Donnelly
authors: Spencer J
authors: SJ
authors: Williams
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D012834:Silver / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D014230:Triazoles; D012834:Silver; D003300:Copper