title: Epstein-Barr virus and breast cancer: serological study in a high-incidence area of nasopharyngeal carcinoma.
abstract: We investigated IgA and IgG levels against EBV viral capsid antigen (VCA) and nuclear antigen-1 (EBNA-1) in serum of 223 women with breast cancer (BC) and 309 controls in Guangzhou, China. VCA IgA levels were significantly associated with an elevated risk of BC, with adjusted ORs (95%CIs) of 1.70 (1.05-2.76) (seropositivity) and 2.21 (1.11-4.40) (unit increases in OD value). This association was stronger among young, lean, and HER2+ women. The EBNA-1 IgA levels in OD value, but not seropositivity, were associated with an increased risk of BC among ER+, PR+, and HER2+ patients. None of the IgG variables was related to BC. These results suggest the EBV association with BC in an endemic area of nasopharyngeal carcinoma.
authors: The School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Rd., Guangzhou 510080, China.
authors: Jian-Rong
authors: JR
authors: He
authors: Lu-Ying
authors: LY
authors: Tang
authors: Dan-Dan
authors: DD
authors: Yu
authors: Feng-Xi
authors: FX
authors: Su
authors: Er-Wei
authors: EW
authors: Song
authors: Ying
authors: Y
authors: Lin
authors: Shen-Ming
authors: SM
authors: Wang
authors: Guan-Chao
authors: GC
authors: Lai
authors: Wei-Qing
authors: WQ
authors: Chen
authors: Ze-Fang
authors: ZF
authors: Ren
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology*; D001943:Breast Neoplasms / Q000097:blood / Q000276:immunology / Q000821:virology*; D036022:Capsid Proteins / Q000276:immunology*; D002277:Carcinoma; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D015994:Incidence; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012306:Risk
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D019309:Epstein-Barr Virus Nuclear Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C041788:Epstein-Barr viral capsid antigen; C508053:ERBB2 protein, human; C417029:EBV-encoded nuclear antigen 1