title: Vitreous levels of soluble vascular endothelial growth factor receptor (VEGFR)-1 in eyes with vitreoretinal diseases.
abstract: OBJECTIVE
  To determine the vitreous levels of soluble vascular endothelial growth factor receptor (sVEGFR)-1 in patients with various vitreoretinal diseases, and to investigate its correlation with patients' age and the activity of proliferative diabetic retinopathy (PDR).
  
  
  METHODS
  Vitreous fluid samples were obtained from 187 eyes of 170 patients who underwent vitrectomy for the treatment of idiopathic macular hole (MH, n=30), branch retinal vein occlusion (BRVO, n=37), central retinal vein occlusion (CRVO, n=27), diabetic macular oedema (DME, n=42) and PDR (n=51). The levels of sVEGFR-1 in the vitreous were measured by ELISA.
  
  
  RESULTS
  The levels of sVEGFR-1 (pg/ml) were not significantly different among each disease examined (MH 3900.1 ± 1188.9, BRVO 3969.7 ± 1741.6, CRVO 4897.7 ± 1717.7, DME 3856.21 ± 1374.7, PDR 4212.3 ± 1474.9). There was a significant positive correlation between vitreous concentrations of sVEGFR-1 and patients' age (r=0.430, p<0.01). The sVEGFR-1 concentration in subjects with active PDR was significantly lower than in those with quiescent PDR (p<0.0001), even after being adjusted for age (p<0.0001).
  
  
  CONCLUSIONS
  Vitreous concentrations of sVEGFR-1 increase with advancing age and are associated with quiescent rather than active PDR even after adjustment for age.
authors: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Ryo
authors: R
authors: Asato
authors: Takeshi
authors: T
authors: Kita
authors: Shuhei
authors: S
authors: Kawahara
authors: Ryoichi
authors: R
authors: Arita
authors: Yasutaka
authors: Y
authors: Mochizuki
authors: Lloyd Paul
authors: LP
authors: Aiello
authors: Tatsuro
authors: T
authors: Ishibashi
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003930:Diabetic Retinopathy / Q000378:metabolism* / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000378:metabolism* / Q000473:pathology; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism* / Q000473:pathology
chemical_list: D005136:Eye Proteins; D040281:Vascular Endothelial Growth Factor Receptor-1