title: Antitumor activities and interaction with DNA of oxaliplatin-type platinum complexes with linear or branched alkoxyacetates as leaving groups.
abstract: Five oxaliplatin-typed platinum complexes containing trans-1R, 2R-diaminocyclohexane chelating platinum cores, characteristic of linear or branched alkoxycarboxylates as leaving groups, were biologically evaluated. These compounds showed higher antitumor activity, lower toxicity in vivo than cisplatin or oxaliplatin. And the results revealed that the antitumor activity and interaction with DNA of these compounds were highly related to the nature of leaving groups. Among these complexes, 5a, cis-(trans-1R, 2R-diaminocyclohexane) bis (2-tert-butoxyacetate) platinum(II), showed the highest antitumor activity and the lowest toxicity.
authors: Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
authors: Runting
authors: R
authors: Yin
authors: Shaohua
authors: S
authors: Gou
authors: Xia
authors: X
authors: Liu
authors: Liguang
authors: L
authors: Lou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity*; D017209:Apoptosis; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000633:toxicity*; D000077150:Oxaliplatin; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: C562059:(diaminocyclohexane)bis(2-tert-butoxyacetate)platinum(II); D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D004247:DNA