title: Development of breast cancer in a 21-year-old childhood Wilms' tumor survivor with a BRCA1 2634delC mutation.
abstract: Breast cancer at age 21 is rare, even in individuals who have a genetic predisposition. These early diagnoses are usually the result of a hereditary cancer syndrome. Other contributing factors, such as chemotherapy and radiation for previous malignancies, can also increase the risk of secondary malignancies, including breast cancer. Here we present one of the youngest cases of breast cancer reported in the literature: a 21-year-old Wilms' tumor survivor (diagnosed at age 6), who was found to have a familial BRCA1 mutation and was diagnosed with ductal carcinoma in situ at age 21.
authors: Virginia G. Piper Cancer Center, Scottsdale Healthcare, 10510 N. 92nd Street, Scottsdale, AZ 85258, USA.
authors: Alexandra M
authors: AM
authors: Dulude
authors: Joyce
authors: J
authors: D'Souza
authors: Nedra
authors: N
authors: Harrison
authors: Ramesh K
authors: RK
authors: Ramanathan
mesh_terms: D000328:Adult; D019313:BRCA1 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy; D009154:Mutation / Q000235:genetics*; D011379:Prognosis; D017384:Sequence Deletion; D017741:Survivors; D009396:Wilms Tumor / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D055815:Young Adult
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human