title: Synthesis, characterization and biological evaluation of platinum(II) complexes with a chiral N-monosubstituted 1,2-cyclohexyldiamine derivative.
abstract: Eight platinum(II) compounds with a new chiral ligand, 2-(((1R,2R)-2-aminocyclohexylamino)methyl)phenol (HL), were designed, prepared and spectrally characterized. All compounds showed better aqueous solubility than cisplatin and oxaliplatin. In vitro cytotoxicity of these compounds against human HepG-2, MCF-7, A549 and HCT-116 cell lines was evaluated. Results indicated that all compounds showed cytotoxicity against A549 and HepG-2 cell lines. Particularly, compounds B1 and B8, which have CF₃SO₃⁻ and (CH₃)₃COCH₂COO(-) as leaving groups, respectively, exhibited better cytotoxicitiy than that of carboplatin in these two cell lines.
authors: Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University.
authors: Chuanzhu
authors: C
authors: Gao
authors: Shaohua
authors: S
authors: Gou
authors: Gang
authors: G
authors: Xu
mesh_terms: D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D003959:Diamines / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008024:Ligands; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D010984:Platinum / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D003959:Diamines; D008024:Ligands; D009944:Organoplatinum Compounds; D010984:Platinum