title: Sesquiterpenoids from Trichoderma atroviride, an endophytic fungus in Cephalotaxus fortunei.
abstract: Two new sesquiterpenoids, identified as (rel 1S, 3R, 4R, 7R)-3-[5-hydroxy-4-methylpent-3-enyl]-1, 3, 7-trimethyl-2-oxabicyclo [2, 2, 1] heptane (1) and (rel 1S, 3R, 4R, 7R)-3-[3, 4-dihydroxy-4-methylpentyl]-1, 3, 7-trimethyl-2-oxabicyclo [2, 2, 1] heptane (2), were isolated from cultures of Trichoderma atroviride (strain no. S361), an endophytic fungal strain residing in the bark of Cephalotaxus fortunei. The structures of compounds 1 and 2 were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data. Both compounds 1 and 2 were potent inhibitors on NO production in LPS-stimulated RAW264.7 cells, with IC₅₀ values of 15.3 and 9.1μM, respectively.
authors: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
authors: Cheng-Jian
authors: CJ
authors: Zheng
authors: Pei-Xin
authors: PX
authors: Sun
authors: Gui-Lin
authors: GL
authors: Jin
authors: Lu-Ping
authors: LP
authors: Qin
mesh_terms: D000818:Animals; D001688:Biological Products / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D032483:Cephalotaxus / Q000382:microbiology*; D060026:Endophytes; D008070:Lipopolysaccharides; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014242:Trichoderma / Q000737:chemistry*
chemical_list: C570388:(rel 1S,3R,4R,7R)-3-(3,4-dihydroxy-4-methylpent-3-enyl)-1, 3, 7-trimethyl-2-oxabicyclo(2, 2,1)heptane; C570387:(rel 1S,3R,4R,7R)-3-(5-hydroxy-4-methylpent-3-enyl)-1, 3, 7-trimethyl-2-oxabicyclo(2, 2,1)heptane; D001688:Biological Products; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide