title: No influence on disease progression of non-HLA susceptibility genes in MS.
abstract: Recently, several non-HLA loci have been shown to be convincingly associated with Multiple Sclerosis (MS) susceptibility, assumingly indicating important pathways in the pathogenesis. A genotype influence on disease outcome measures by these genes would support a role of these pathways in ongoing tissue damage. Here, however, we report a consistent dissociation between causation and progression for five non-HLA genotypes (IL7R, IL2RA, CLEC16A, CD226 and SH2B3) in 1776 Scandinavian MS patients.
authors: The Multiple Sclerosis Research group, Centre for Molecular Medicine, Department of Clinical neuroscience, Karolinska Institutet, Stockholm, Sweden. wangko.lundstrom@ki.se
authors: Wangko
authors: W
authors: Lundström
authors: Eva
authors: E
authors: Greiner
authors: Frida
authors: F
authors: Lundmark
authors: Helga
authors: H
authors: Westerlind
authors: Cathrine
authors: C
authors: Smestad
authors: Aslaug R
authors: AR
authors: Lorentzen
authors: Ingrid
authors: I
authors: Kockum
authors: Jenny
authors: J
authors: Link
authors: Boel
authors: B
authors: Brynedal
authors: Elisabeth G
authors: EG
authors: Celius
authors: Hanne F
authors: HF
authors: Harbo
authors: Thomas
authors: T
authors: Masterman
authors: Jan
authors: J
authors: Hillert
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics / Q000276:immunology; D000954:Antigens, Surface / Q000235:genetics* / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000235:genetics / Q000276:immunology; D047908:Intracellular Signaling Peptides and Proteins; D037181:Lectins, C-Type / Q000235:genetics / Q000276:immunology; D008297:Male; D009004:Monosaccharide Transport Proteins / Q000235:genetics / Q000276:immunology; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D009664:Norway / Q000453:epidemiology; D011506:Proteins / Q000235:genetics / Q000276:immunology; D020395:Receptors, Interleukin-7 / Q000235:genetics / Q000276:immunology; D013548:Sweden / Q000453:epidemiology; D000098862:T Lineage-Specific Activation Antigen 1
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D000098862:T Lineage-Specific Activation Antigen 1; C522505:CLEC16A protein, human; D006680:HLA Antigens; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D047908:Intracellular Signaling Peptides and Proteins; D037181:Lectins, C-Type; D009004:Monosaccharide Transport Proteins; D011506:Proteins; D020395:Receptors, Interleukin-7; C490778:SH2B3 protein, human