title: [Effect of different doses of fentanyl and butylhyoscine on the rabbit's sphincter of Oddi].
abstract: BACKGROUND
  It was not until the advent of endoscopic retrograde cholangiopancreatography (ERCP) that Oddi's sphincter manometry was performed directly. Use of opioids for the intravenous (IV) sedation of these patients is controversial.
  
  
  OBJECTIVE
  To evaluate with manometry the effect of fentanyl at different doses as well as the effect of butylhyoscine on the rabbit's Oddi's sphincter.
  
  
  METHODS
  This is an experimental, randomized, double-blind study conducted in New Zealand rabbits distributed in 4 groups (control, fentanyl at doses of 1, 5 and 10 μg/kg of weight) that, after laparotomy and duodenotomy, underwent direct Oddi's sphincter manometry. The analyzed variables included sphincter pressure, wave frequency, amplitude and duration.
  
  
  RESULTS
  The baseline measurements of the study variables did not show any differences among the groups. The administration of fentanyl at 1 μg/kg reduced Oddi's sphincter pressure compared with the baseline value (p = 0.003), while the doses of 5 and 10 μg/kg significantly increased it (p <0.0001). Butylhyoscine decreased the sphincter pressure, frequency, amplitude and duration of the waves in all the groups and antagonized the increase in pressure produced by fentanyl.
  
  
  CONCLUSIONS
  Fentanyl at 1 μg/kg of body weight relaxes the rabbit's Oddi's sphincter and butylhyoscine can antagonize the increased pressure of the sphincter caused by fentanyl at 5 and 10 μg/kg of weight. These finding suggest a potential beneficial for the ERCP in clinical controlled trials in humans.
authors: Departamento de Endoscopia Digestiva, Hospital de Especialidades UMAE N° 134 Instituto Mexicano del Seguro Social. aguitron@prodigy.net.mx
authors: A
authors: A
authors: Güitrón-Cantú
authors: F K
authors: FK
authors: Segura-López
authors: G
authors: G
authors: Limones-Ortiz
authors: C
authors: C
authors: Rascón
authors: S
authors: S
authors: Moreno-Ávalos
authors: L
authors: L
authors: Pérez-Solís
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D016292:Procedural Sedation / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology*; D008365:Manometry / Q000379:methods*; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects; D011817:Rabbits; D012601:Scopolamine / Q000008:administration & dosage / Q000494:pharmacology*; D009803:Sphincter of Oddi / Q000187:drug effects*
chemical_list: D000701:Analgesics, Opioid; D018727:Muscarinic Antagonists; D012601:Scopolamine; D005283:Fentanyl