title: Time-dependent in-vivo effects of interleukin-2 on neurotransmitters in various cortices: relationships with depressive-related and anxiety-like behaviour.
abstract: We investigated the impact of systemically injected IL-2 (2.5 μg/kg, i.p.) on serotonergic and dopaminergic neurotransmission in various cortical areas by in-vivo microdialysis. IL-2 lastingly reduced extracellular 5-HT levels in the medial prefrontal (-75%), occipital (-70%), and temporal cortices (-45%), whereas dopamine was only moderately reduced in the medial prefrontal cortex. Based on the serotonergic time profile, we conducted further experiments to test for acute and delayed (2 h post injection) depressive-related effects of systemic IL-2 (0-5.0 μg/kg) in a forced swim test and delayed effects on anxiety-like behaviour in the elevated plus-maze. IL-2 had dose-dependent effects on depressive-related behaviour after delayed but not acute testing, but no effects on anxiety-like behaviour.
authors: Department of Physiological Psychology, Philipps-University Marburg, Germany. karrenbb@staff.uni-marburg.de
authors: B D
authors: BD
authors: Karrenbauer
authors: C P
authors: CP
authors: Müller
authors: Y J
authors: YJ
authors: Ho
authors: R
authors: R
authors: Spanagel
authors: J P
authors: JP
authors: Huston
authors: R K W
authors: RK
authors: Schwarting
authors: C R
authors: CR
authors: Pawlak
mesh_terms: D000818:Animals; D001008:Anxiety Disorders / Q000276:immunology* / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000276:immunology*; D003866:Depressive Disorder / Q000276:immunology* / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000502:physiology; D007376:Interleukin-2 / Q000502:physiology*; D008297:Male; D017551:Microdialysis; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000502:physiology; D013315:Stress, Psychological / Q000276:immunology / Q000378:metabolism; D013997:Time Factors
chemical_list: D007376:Interleukin-2; D012701:Serotonin; D004298:Dopamine