title: Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.
abstract: A high throughput screen for inhibitors of the oncogenic transcription factor activator protein-1 (AP-1) was applied to the NCI repository of natural product extracts. The liphophilic extract of the plant Nothospondias staudtii (Simaroubaceae) displayed significant AP-1 inhibition. Bioassay-guided fractionation of the extract lead to a new quassinoid named nothospondin (1), and the known compound glaucarubinone (2). The structure of 1 was elucidated by spectroscopic methods. Compounds 1 and 2 showed potent, dose-dependent AP-1 inhibition at noncytotoxic concentrations.
authors: Molecular Targets Laboratory, Center for Cancer Research, NCI-Frederick, Frederick, MD 21702, USA.
authors: Thushara
authors: T
authors: Diyabalanage
authors: Ranjala
authors: R
authors: Ratnayake
authors: Jennifer A
authors: JA
authors: Wilson
authors: Curtis J
authors: CJ
authors: Henrich
authors: John A
authors: JA
authors: Beutler
authors: Nancy H
authors: NH
authors: Colburn
authors: James B
authors: JB
authors: McMahon
authors: Kirk R
authors: KR
authors: Gustafson
mesh_terms: D002163:Cameroon; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029641:Simaroubaceae / Q000737:chemistry*; D018808:Transcription Factor AP-1 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D003374:Coumarins; D010616:Phenanthrenes; D010936:Plant Extracts; D018808:Transcription Factor AP-1; C562330:nothospondin