title: Bone mineral density and joint cartilage: four clinical settings of a complex relationship in osteoarthritis.
abstract: Experimental and clinical data support the hypothesis that both high and low bone mineral density (BMD) conditions, including osteoporosis, may induce osteoarthritis. However, these conditions do not always predispose to osteoarthritis progression. Four clinical settings could arise from this relationship, and furthermore two phenotypes may be identified whether early osteoarthritis coexists with high or low BMD.
authors: Bone and Joint Research Unit, Service of Rheumatology, IIS-Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain. gherrero@fjd.es
authors: Gabriel
authors: G
authors: Herrero-Beaumont
authors: Jorge A
authors: JA
authors: Roman-Blas
authors: Raquel
authors: R
authors: Largo
authors: Francis
authors: F
authors: Berenbaum
authors: Santos
authors: S
authors: Castañeda
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology*; D002357:Cartilage Diseases / Q000150:complications / Q000503:physiopathology; D002358:Cartilage, Articular / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D010003:Osteoarthritis / Q000150:complications / Q000503:physiopathology*; D010024:Osteoporosis / Q000150:complications / Q000503:physiopathology