title: Deregulated expression of superoxide dismutase-2 correlates with different stages of cervical neoplasia.
abstract: OBJECTIVE
  Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer.
  
  
  METHODS
  In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO).
  
  
  RESULTS
  We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining.
  
  
  CONCLUSIONS
  Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease.
authors: Ludwig Institute for Cancer Research - Hospital Alemão Oswaldo Cruz, São Paulo (SP), Brazil. ltermini@vrg.ludwig.org.br
authors: Lara
authors: L
authors: Termini
authors: Adhemar Longatto
authors: AL
authors: Filho
authors: Paulo Cesar
authors: PC
authors: Maciag
authors: Daniela
authors: D
authors: Etlinger
authors: Venâncio Avancini Ferreira
authors: VA
authors: Alves
authors: Suely
authors: S
authors: Nonogaki
authors: Fernando Augusto
authors: FA
authors: Soares
authors: Luisa Lina
authors: LL
authors: Villa
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009367:Neoplasm Staging; D016017:Odds Ratio; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000099156:Superoxide Dismutase 2
chemical_list: D014408:Biomarkers, Tumor; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2