title: Antibacterial polyketides from the jellyfish-derived fungus Paecilomyces variotii.
abstract: Four new polyketides (1-4) were isolated from the fungus Paecilomyces variotii, which was derived from the jellyfish Nemopilema nomurai. The planar structures and relative configurations of these polyketides were elucidated on the basis of spectroscopic analyses, including 2D NMR experiments. The compounds showed inhibitory activity against pathogenic bacteria including methicillin-resistant Staphylococcus aureus 3089 and multi-drug-resistant Vibrio parahemolyticus 7001 with MIC values in the range 5-40 μg/mL.
authors: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors: Juan
authors: J
authors: Liu
authors: Famei
authors: F
authors: Li
authors: Eun La
authors: EL
authors: Kim
authors: Jian Lin
authors: JL
authors: Li
authors: Jongki
authors: J
authors: Hong
authors: Kyung Sook
authors: KS
authors: Bae
authors: Hae Young
authors: HY
authors: Chung
authors: Hyung Sik
authors: HS
authors: Kim
authors: Jee H
authors: JH
authors: Jung
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000187:drug effects; D007189:Indans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010143:Paecilomyces / Q000737:chemistry*; D037401:Scyphozoa / Q000382:microbiology*; D014736:Vibrio parahaemolyticus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001572:Benzofurans; D007189:Indans; D018942:Macrolides