title: Effects of root and stem extracts of Asparagus cochinchinensis on biochemical indicators related to aging in the brain and liver of mice.
abstract: Asparagus cochinchinensis is a traditional Chinese medicine used for treating lung and spleen-related diseases. In this study, we compared the medicinal effects of A. cochinchinensis root and stem extracts on the activity of superoxide dismutase (SOD), the content of malonaldehyde (MDA) and total protein content in the brain, liver and plasma of mice. Polysaccharides and aqueous extracts of the roots significantly increased the spleen index and the SOD activity but reduced the MDA content and slowed down the aging process. In contrast, feeding with the stem extracts significantly reduced the SOD activity and increased the MDA accumulation in the brain and liver of mice, suggesting that the stem extracts may not be appropriate for treating aging-related diseases.
authors: College of Life Science, Hunan University of Arts and Science, Changde, Hunan 415000, China. xiongdasheng@126.com
authors: Dasheng
authors: D
authors: Xiong
authors: Long-Xi
authors: LX
authors: Yu
authors: Xiao
authors: X
authors: Yan
authors: Chunqiu
authors: C
authors: Guo
authors: Ying
authors: Y
authors: Xiong
mesh_terms: D000375:Aging / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D027761:Asparagus Plant / Q000737:chemistry*; D015415:Biomarkers / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D051379:Mice; D018517:Plant Roots; D018547:Plant Stems; D018514:Plant Structures; D011134:Polysaccharides / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D013154:Spleen / Q000187:drug effects; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; D011506:Proteins; D008315:Malondialdehyde; D013482:Superoxide Dismutase