title: Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers.
abstract: 7
  
  
  BACKGROUND
  No generally agreed-upon method is available for predicting the prognosis of salivary gland cancers. RB1-inducible coiled-coil 1 (RB1CC1) is a positive regulator for the retinoblastoma tumor suppressor (RB1) pathway, and is a suitable marker for evaluating the clinical course of breast cancer. We investigated whether RB1CC1 predicts the prognosis of salivary gland cancers.
  
  
  METHODS
  Molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and Ki-67, were evaluated immunohistochemically in 36 cases of salivary gland cancers. The relationships between clinicopathologic features and disease-free-survival intervals were analyzed by a Kaplan-Meier log-rank test and a multivariate Cox proportional hazard regression.
  
  
  RESULTS
  Nuclear RB1CC1 loss in the tumors was significantly associated with a worse disease-free survival (log-rank test, chi-square value = 11.644, p = .0006), and was the maximum critical risk (multivariate Cox proportional hazard ratio = 11.112, 95% confidence interval [CI] = 1.776-69.510, p = .0100).
  
  
  CONCLUSIONS
  Nuclear expression of RB1CC1 predicts a better clinical outcome and is useful in the follow-up of salivary gland cancers.
authors: Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Japan.
authors: Hitosuke
authors: H
authors: Tameno
authors: Tokuhiro
authors: T
authors: Chano
authors: Kaichiro
authors: K
authors: Ikebuchi
authors: Yasuko
authors: Y
authors: Ochi
authors: Akihito
authors: A
authors: Arai
authors: Mitsuo
authors: M
authors: Kishimoto
authors: Taketoshi
authors: T
authors: Shimada
authors: Yasuo
authors: Y
authors: Hisa
authors: Hidetoshi
authors: H
authors: Okabe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000071183:Autophagy-Related Proteins; D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000628:therapy; D055815:Young Adult
chemical_list: D000071183:Autophagy-Related Proteins; D014408:Biomarkers, Tumor; C407704:RB1CC1 protein, human; D011505:Protein-Tyrosine Kinases