title: Immediate and delayed hypersensitivity to corticosteroids.
abstract: Corticosteroids are therapeutic agents used in cases of allergy and intolerance. Due to the antiinflammatory effects of the corticosteroids, hypersensitivity reactions often are considered to be a paradox. However, delayed-type reaction to corticosteroids is a frequent phenomenon in the daily routine. Non-responding eczema, development of subacute contact eczema, systemic contact dermatitis or maculopapular exanthemas can be a clinical symptom of a delayed-type hypersensitivity reaction to corticosteroids. Immediate-type hypersensitivity reactions to corticosteroids remain uncommon. Nevertheless, they can take a severe clinical course. Patients react with anaphylaxis after systemic administration or with aggravation of an allergic reaction under therapy with corticosteroids. Allergologic testing is necessary for diagnosis and providing alternative corticosteroids in case of an emergency.
authors: Department of Dermatology, University of Munich, Germany.
authors: Sarah
authors: S
authors: Basedow
authors: Sibylle
authors: S
authors: Eigelshoven
authors: Bernhard
authors: B
authors: Homey
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000145:classification / Q000627:therapeutic use; D000707:Anaphylaxis / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D003875:Drug Eruptions / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D007428:Intradermal Tests; D010328:Patch Tests; D013329:Structure-Activity Relationship
chemical_list: D000305:Adrenal Cortex Hormones