title: Overweight as a prognostic factor in children with acute lymphoblastic leukemia.
abstract: Our purpose was to investigate the prognostic impact of overweight/obesity in 5-year event-free survival (EFS) in a cohort of children with acute lymphoblastic leukemia (ALL). We retrospectively analyzed 181 newly diagnosed ALL children enrolled between 1990 and 2009 and treated with Berlin-Frankfurt-Munich (BFM) protocols. The majority of children in our cohort were <10 years-old. Our data clearly indicated that overweight/obesity is an independent predictor of relapse risk, mainly in the intermediate- and high-risk groups (HR) of children. These results could be explained by changes in the chemotherapy pharmacokinetics in overweight/obese patients and by the antiapoptotic effects in leukemic cells caused by adipocytes.
authors: Pediatrics Institute IPPMG, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. elainesc@centroin.com.br
authors: Cristina B
authors: CB
authors: Gelelete
authors: Sandra H
authors: SH
authors: Pereira
authors: Alice Maria B
authors: AM
authors: Azevedo
authors: Leandro S
authors: LS
authors: Thiago
authors: Mariana
authors: M
authors: Mundim
authors: Marcelo G P
authors: MG
authors: Land
authors: Elaine S
authors: ES
authors: Costa
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006776:Hospitals, Pediatric; D006801:Humans; D008297:Male; D050177:Overweight / Q000150:complications*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D012306:Risk; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents