title: [1059 g/c gene polymorphism of C-reactive protein in patients with deep vein thrombosis].
abstract: This study was aimed to investigate the distribution of 1059 G/C gene polymorphism of C-reactive protein(CRP) in deep vein thrombus (DVT) and its clinical significance. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to screen 1059 G/C polymorphism in exon 2 of C-reactive protein gene in 61 cases of DVT and 60 healthy controls. The frequency of mutation was calculated. The results showed that there was no statistical difference of 1059 G/C genotype and mutation frequency of allele between deep vein thrombosis group and control group (p > 0.05). It is concluded that the 1059 G/C gene polymorphism of CRP displays certain difference in races and areas, and whether 1059 G/C gene polymorphism of CRP is a dangerous factor for deep vein thrombosis, which needs to be deeply explored.
authors: Department of Hematology, Shanxi Medical University Second Hospital, Taiyuan 030001, Shanxi Province, China.
authors: Mei-Fang
authors: MF
authors: Wang
authors: Lin-Hua
authors: LH
authors: Yang
authors: Xiao-Ling
authors: XL
authors: Yang
authors: Rui-Juan
authors: RJ
authors: Zhang
authors: Chun-Xia
authors: CX
authors: Dong
authors: Li-Hong
authors: LH
authors: Hou
authors: Xiu-E
authors: XE
authors: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000235:genetics*; D016022:Case-Control Studies; D005091:Exons; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020246:Venous Thrombosis / Q000235:genetics*; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein