title: Oligophenylenaminones as scaffolds for α-helix mimicry.
abstract: The design and synthesis of small molecule α-helix mimetics has been a productive field over the past decade. These compounds have performed well in a variety of biological systems as functional disruptors of α-helix-mediated protein-protein interactions. In our studies we have continued to develop novel, more biologically compatible scaffolds, which are often easier to assemble and capable of mimicking longer and/or more diverse helices. To this end, we have constructed a new series of i, i+4, i+7 α-helix mimics based on the enaminone scaffold. These molecules represent a step forward in the pursuit of idealized monofacial α-helix mimetics.
authors: University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.
authors: Marc J
authors: MJ
authors: Adler
authors: Andrew D
authors: AD
authors: Hamilton
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry*; D032701:Biomimetics; D015195:Drug Design; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D017433:Protein Structure, Secondary
chemical_list: D000475:Alkenes; D000588:Amines; D001593:Benzyl Compounds; D007659:Ketones