title: Aloe vera or resveratrol supplementation in larval diet delays adult aging in the fruit fly, Drosophila melanogaster.
abstract: Longevity extension in Drosophila melanogaster by feeding diet supplemented with chemicals throughout adulthood can cause harmful side effects. We tested the effect of larval diet supplementation with five different concentrations of resveratrol and one concentration of Aloe vera extract on the adult longevity of short-lived D melanogaster populations. Resveratrol and A vera extract supplementation of larval diet extended adult longevity in both the male and female flies without reducing fecundity but by efficient reactive oxygen species scavenging through increased antioxidant enzymes activity and better neuroprotection as indicated by increased locomotor activity in adult males.
authors: Department of Zoology, University of Delhi, Delhi, India.
authors: Kagepura Thammaiah
authors: KT
authors: Chandrashekara
authors: Mallikarjun N
authors: MN
authors: Shakarad
mesh_terms: D000375:Aging; D000504:Aloe; D000818:Animals; D001835:Body Weight; D002374:Catalase / Q000378:metabolism; D004331:Drosophila melanogaster / Q000502:physiology*; D005260:Female; D005298:Fertility; D007814:Larva; D008055:Lipids / Q000032:analysis; D008136:Longevity; D009043:Motor Activity; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D008055:Lipids; D013267:Stilbenes; D002374:Catalase; D013482:Superoxide Dismutase; D000077185:Resveratrol