title: Aptamer-conjugated DNA icosahedral nanoparticles as a carrier of doxorubicin for cancer therapy.
abstract: DNA can be used to nanofabricate three-dimensional (3D) polyhedra. A variety of applications of 3D DNA assemblies have been proposed. Drug encasulation and intracellular delivery using DNA nanoparticles, however, have remained a challenge. Here, we create a distinct five-point-star motif and aptamer-conjugated six-point-star motif using well-used primer sequences to intermolecularly construct DNA icosahedra as a nanocarrier for doxorubicin. Aptamer-conjugated doxorubicin-intercalated DNA icosahedra (Doxo@Apt-DNA-icosa) show an efficient and specific internalization for killing epithelial cancer cells.
authors: Center for Nanomedicine Research, National Health Research Institutes, Miaoli, Taiwan.
authors: Microsugar
authors: M
authors: Chang
authors: Chung-Shi
authors: CS
authors: Yang
authors: Dong-Ming
authors: DM
authors: Huang
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D016466:CHO Cells; D045744:Cell Line, Tumor; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D004317:Doxorubicin / Q000494:pharmacology* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D052157:Aptamers, Nucleotide; D004337:Drug Carriers; D004317:Doxorubicin; D004247:DNA