title: Retinoid-related orphan receptor alpha and the regulation of lipid homeostasis.
abstract: Many nuclear hormone receptors (NRs) control lipid, glucose and energy homeostasis in an organ specific manner. Concordantly, dysfunctional NR signalling results in metabolic disease. The Retinoic acid receptor-related orphan receptor alpha (RORα), a member of the NR1F subgroup, is expressed in metabolic tissues. Previous studies identified the role of this NR in dyslipidemia, apo-lipoprotein metabolism and atherosclerosis. Recent data is underscoring the significant role of this orphan NR in the regulation of phase I/II metabolism (bile acids, xenobiotics, steroids etc.), adiposity, insulin signalling, and glucose tolerance. Moreover, oxygenated sterols, have been demonstrated to function as native ligands and inverse agonists. This review focuses on the rapidly emerging and evolving role of RORα in the control of lipid and glucose homeostasis in major mass metabolic tissues. Article from the special issue orphan receptors.
authors: Obesity Research Centre, Institute for Molecular Bioscience, University of Queensland, Services Rd St. Lucia, Queensland, 4072 Australia.
authors: Rebecca L
authors: RL
authors: Fitzsimmons
authors: Patrick
authors: P
authors: Lau
authors: George E O
authors: GE
authors: Muscat
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D005260:Female; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects / Q000502:physiology*; D052439:Lipid Metabolism Disorders / Q000188:drug therapy / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000819:agonists / Q000378:metabolism*
chemical_list: D057094:Nuclear Receptor Subfamily 1, Group F, Member 1