title: Ivermectin mass drug administration to humans disrupts malaria parasite transmission in Senegalese villages.
abstract: Ivermectin mass drug administration (MDA) to humans is used to control onchocerciasis and lymphatic filariasis. Recent field studies have shown an added killing effect of ivermectin MDA against malaria vectors. We report that ivermectin MDA reduced the proportion of Plasmodium falciparum infectious Anopheles gambiae sensu stricto (s.s.) in treated villages in southeastern Senegal. Ivermectin MDA is a different delivery method and has a different mode of action from current malaria control agents. It could be a powerful and synergistic new tool to reduce malaria transmission in regions with epidemic or seasonal malaria transmission, and the prevalence and intensity of neglected tropical diseases.
authors: Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1692, USA. kobylinskikevin@yahoo.com
authors: Kevin C
authors: KC
authors: Kobylinski
authors: Massamba
authors: M
authors: Sylla
authors: Phillip L
authors: PL
authors: Chapman
authors: Moussa D
authors: MD
authors: Sarr
authors: Brian D
authors: BD
authors: Foy
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage*; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage*; D008288:Malaria / Q000188:drug therapy* / Q000635:transmission; D012675:Senegal
chemical_list: D000962:Antimalarials; D007559:Ivermectin