title: Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure.
abstract: Hyperthermia and local drug delivery have been proposed as potential therapeutic approaches for bone defects resulting from malignant bone tumors. The development of bioactive materials with magnetic and drug delivery properties may potentially meet this target. The aim of this study was to develop a multifunctional mesoporous bioactive glass (MBG) scaffold system for both hyperthermic and local drug delivery applications. To this end iron (Fe)-containing MBG (Fe-MBG) scaffolds with a hierarchical large pores structure (300-500 μm) and fingerprint-like mesopores (4.5 nm) have been prepared. The effects of Fe on the mesopore structure and physiochemical, magnetic, drug delivery and biological properties of MBG scaffolds have been systematically investigated. The results show that the morphology of the mesopores varied from straight channels to curved fingerprint-like channels after incorporation of Fe into MBG scaffolds. The magnetism of MBG scaffolds can be tailored by controlling the Fe content. Furthermore, the incorporation of Fe into mesoporous MBG glass scaffolds enhanced the mitochondrial activity and the expression of bone-related genes (ALP and OCN) in human bone marrow mesenchymal stem cells (BMSC) attached to the scaffolds. The Fe-MBG scaffolds obtained also possessed high specific surface areas and demonstrated sustained drug delivery. Thus Fe-MBG scaffolds are magnetic, degradable and bioactive. The multifunctionality of Fe-MBG scaffolds suggests that there is great potential for their use in the treatment and regeneration of large-bone defects caused by malignant bone tumors through a combination of hyperthermia, local drug delivery and osteoconductivity.
authors: Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China. chengtie.wu@qut.edu.au
authors: Chengtie
authors: C
authors: Wu
authors: Wei
authors: W
authors: Fan
authors: Yufang
authors: Y
authors: Zhu
authors: Michael
authors: M
authors: Gelinsky
authors: Jiang
authors: J
authors: Chang
authors: Gianaurelio
authors: G
authors: Cuniberti
authors: Victoria
authors: V
authors: Albrecht
authors: Thor
authors: T
authors: Friis
authors: Yin
authors: Y
authors: Xiao
mesh_terms: D000368:Aged; D001672:Biocompatible Materials / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D005898:Glass / Q000737:chemistry*; D006801:Humans; D007477:Ions; D007501:Iron / Q000494:pharmacology; D008280:Magnetics; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008903:Minerals / Q000737:chemistry; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008954:Models, Biological; D016062:Porosity / Q000187:drug effects; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D007477:Ions; D008903:Minerals; D003907:Dexamethasone; D007501:Iron