title: Genetic determinants for intramuscular fat content and water-holding capacity in mice selected for high muscle mass.
abstract: Intramuscular fat content and water-holding capacity are important traits in livestock as they influence meat quality, nutritive value of the muscle, and animal health. As a model for livestock, two inbred lines of the Berlin Muscle Mouse population, which had been long-term selected for high muscle mass, were used to identify genomic regions affecting intramuscular fat content and water-holding capacity. The intramuscular fat content of the Musculus longissimus was on average 1.4 times higher in BMMI806 than in BMMI816 mice. This was accompanied by a 1.5 times lower water-holding capacity of the Musculus quadriceps in BMMI816 mice. Linkage analyses with 332 G(3) animals of reciprocal crosses between these two lines revealed quantitative trait loci for intramuscular fat content on chromosome 7 and for water-holding capacity on chromosome 2. In part, the identified loci coincide with syntenic regions in pigs in which genetic effects for the same traits were found. Therefore, these muscle-weight-selected mouse lines and the produced intercross populations are valuable genetic resources to identify genes that could also contribute to meat quality in other species.
authors: Department for Crop and Animal Sciences, Humboldt-Universität zu Berlin, Invalidenstraße 42, 10115 Berlin, Germany. stefan.kaerst@agrar.hu-berlin.de
authors: Stefan
authors: S
authors: Kärst
authors: Riyan
authors: R
authors: Cheng
authors: Armin O
authors: AO
authors: Schmitt
authors: Hyuna
authors: H
authors: Yang
authors: Fernando Pardo Manuel
authors: FP
authors: de Villena
authors: Abraham A
authors: AA
authors: Palmer
authors: Gudrun A
authors: GA
authors: Brockmann
mesh_terms: D000818:Animals; D001834:Body Water; D001837:Body Weights and Measures; D005223:Fats / Q000032:analysis*; D005260:Female; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000737:chemistry* / Q000378:metabolism; D010641:Phenotype; D040641:Quantitative Trait Loci
chemical_list: D005223:Fats