title: Treatment strategies in acute myeloid leukemia.
abstract: OBJECTIVE
  To summarize the risk stratification and current treatment strategies for acute myeloid leukemia (AML) and discuss the role of emerging novel agents that might be applied in future clinical trials.
  
  
  METHODS
  The data in this article were collected from PubMed database with relevant English articles published from 1991 to 2009.
  
  
  METHODS
  Articles regarding the risk stratification and therapeutic options of AML, as well as the characteristics of leukemic stem cells were selected.
  
  
  RESULTS
  AML is a heterogeneous disease with variable clinical outcome dependent on several prognostic factors, including age, cytogenetics and molecular markers. The advances in the understanding of AML pathogenesis and development will generate potential novel agents that might improve the treatment results of standard chemotherapy.
  
  
  CONCLUSIONS
  Deeper insight into the multiple transforming events of AML may aid us in designing combinations of small molecule inhibitors based on the individual patient characteristics.
authors: Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors: Li-na
authors: LN
authors: Han
authors: Jin
authors: J
authors: Zhou
authors: Jan Jacob
authors: JJ
authors: Schuringa
authors: Edo
authors: E
authors: Vellenga
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents