title: [Analysis of factors of formation and development about degenerative lumbar scoliosis].
abstract: OBJECTIVE
  To investigate the correlation between scoliosis angle and the asymmetric index of degenerative lumbar scoliosis, the degree of intervertebral disc degeneration, decreased bone density.
  
  
  METHODS
  As a retrospectively study, a total of 96 patients with degenerative lumbar scoliosis were retrospectively enrolled from January 2002 to August 2010 as scoliosis group, meanwhile 96 patients with lumbar spinal stenosis matched in gender, age and body mass index (BMI) were selected as control group. All patients were studied with plain radiographs, MRI and dual energy X-ray absorptiometry at presentation. Radiographic measurements include Cobb angle, the height of the convex and concave side of the apical disc and the contiguous disc superiorly and inferiorly, the height of the convex and concave side of the apical and the contiguous vertebral body superiorly and inferiorly in scoliosis group, the height of L(2-3), L(3-4), L(4-5) discs and the height of L(2-4) vertebral body in control group. The average relative signal intensity of lumbar intervertebral disc and cerebrospinal fluid in T2WI sagittal image was measured in apex intervertebral disc and adjacent discs by Adobe Photoshop 6.0 in scoliosis group, which was measured in L(2-3), L(3-4), L(4-5) disc in control group. The bone density of lumbar, femoral neck, trochanter, and Ward's triangle regions were measured with dual-energy X-ray absorptiometry.
  
  
  RESULTS
  The intervertebral disc height in convex side was greater than the height in the concave side [(40 ± 7) mm vs. (28 ± 7) mm, P < 0.01], the vertebral body height in convex side was greater than the height in the concave side [(76 ± 12) mm vs. (72 ± 10) mm, P = 0.016] in scoliosis group. There was significant statistically difference in the degenerative degree of intervertebral discs between two groups (P = 0.003). There was significant statistically difference of the average T-value and the rate of osteoporosis between two groups (P < 0.01). Multiple linear regression analysis showed that the asymmetric disc index, the degenerative degree of intervertebral disc and osteoporosis were the predominant correlative factors, which affected the development of degenerative lumbar scoliosis.
  
  
  CONCLUSIONS
  Degenerative lumbar scoliosis is always accompanied by the height asymmetry of intervertebral discs and vertebral body from convex and concavity sides. There is positive correlation between the angle of scoliosis and the asymmetric disc index, the degeneration of intervertebral disc, and negative correlation between the angle of scoliosis and the bone density (T-value).
authors: Department of Spinal Surgery, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
authors: Wen-yuan
authors: WY
authors: Ding
authors: Lai-zhen
authors: LZ
authors: Cao
authors: Yong
authors: Y
authors: Shen
authors: Wei
authors: W
authors: Zhang
authors: Lin-feng
authors: LF
authors: Wang
authors: Bao-jun
authors: BJ
authors: Li
authors: Ya-peng
authors: YP
authors: Sun
authors: Jin-ku
authors: JK
authors: Guo
mesh_terms: D000368:Aged; D015519:Bone Density; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology*; D016014:Linear Models; D008159:Lumbar Vertebrae / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013130:Spinal Stenosis / Q000473:pathology*