title: Prevention of oxidative DNA degradation by copper-binding peptides.
abstract: Free divalent ions of copper (Cu) are capable of generating radical species such as hydroxyl radicals in the presence of hydrogen peroxide or ascorbic acid through Harbor-Weiss-like reactions under physiological conditions. It has been reported that radical-mediated damage to DNA molecules in animal cells leads to programmed cell death. Hence it is important to seek for methods to prevent Cu-mediated DNA damage. In this study we identified on effect of Cu binding of short peptides (chiefly Gly-Gly-His tripeptide) in the prevention of DNA degradation caused by Cu-mediated reactions in the presence of hydrogen peroxide and of ascorbic acid.
authors: Laboratory of Chemical Biology and Environmental Engineering, Faculty and Graduate School of Environmental Engineering, The University of Kitakyushu, Japan.
authors: Ken
authors: K
authors: Yokawa
authors: Tomoko
authors: T
authors: Kagenishi
authors: Tomonori
authors: T
authors: Kawano
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004249:DNA Damage / Q000187:drug effects*; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000378:metabolism; D017665:Hydroxyl Radical / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D009842:Oligopeptides; D017382:Reactive Oxygen Species; C023548:copper-binding protein; D017665:Hydroxyl Radical; C037026:diglycyl-histidine; D004247:DNA; D006861:Hydrogen Peroxide; D001205:Ascorbic Acid