title: Stroke prevention in atrial fibrillation: current status and near-future directions.
abstract: Prevention of atrial fibrillation-related stroke is an important part of atrial fibrillation management. However, stroke risk is not homogeneous and varies with associated morbidities and risk factors. Risk stratification schemes have been developed that categorize patients' stroke risk into classes based on a combination of risk factors. According to the calculated level of risk, guidelines recommend patients with atrial fibrillation receive antithrombotic therapy either as a vitamin K antagonist or aspirin. Despite recommendations, however, many patients with atrial fibrillation do not receive adequate thromboprophylaxis. We will discuss some of the underlying reasons, in part related to the drawbacks associated with vitamin K antagonists. These highlight the need for new anticoagulants in atrial fibrillation. The novel oral anticoagulants in development may overcome some of the limitations of vitamin K antagonists and address their underuse and safety concerns.
authors: Institute of Cardiology and Center of Excellence on Aging, G. d'Annunzio University, Chieti, Italy. rdecater@unich.it
authors: Raffaele
authors: R
authors: De Caterina
authors: Elaine M
authors: EM
authors: Hylek
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000991:Antithrombins / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D000075202:Contraindications; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D015507:Drugs, Investigational / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019983:Guideline Adherence; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D020521:Stroke / Q000517:prevention & control*; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000991:Antithrombins; D015507:Drugs, Investigational; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents; D014812:Vitamin K; D001241:Aspirin