title: Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhage.
abstract: Inflammation contributes to secondary injury and neuronal loss after intracerebral hemorrhage, but the role of individual immune populations in these processes is unclear. In a mouse model, the injection of autologous blood into the striatum was associated with an intense inflammatory cell infiltrate composed of neutrophils, monocytes, and dendritic cells. Selective depletion of neutrophils resulted in decreased infiltration of monocytes and improved functional outcomes at day 3 post-hemorrhage. These findings indicate that neutrophil infiltration into the site of hemorrhage contributes to brain injury either by direct cellular damage or the recruitment of monocytes.
authors: Department of Neurology, University of Pennsylvania Medical Center, 3 W Gates, 3400 Spruce Street, Philadelphia, PA, USA. lauren.sansing@uphs.upenn.edu
authors: Lauren H
authors: LH
authors: Sansing
authors: Tajie H
authors: TH
authors: Harris
authors: Scott E
authors: SE
authors: Kasner
authors: Christopher A
authors: CA
authors: Hunter
authors: Katalin
authors: K
authors: Kariko
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000911:Antibodies, Monoclonal / Q000009:adverse effects; D000950:Antigens, Ly / Q000276:immunology; D039481:CD11b Antigen / Q000378:metabolism; D039521:CD11c Antigen / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000150:complications / Q000473:pathology / Q000628:therapy; D003713:Dendritic Cells / Q000276:immunology; D004195:Disease Models, Animal; D007839:Functional Laterality / Q000502:physiology; D007249:Inflammation / Q000209:etiology*; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009000:Monocytes / Q000502:physiology*; D020556:Neutrophil Infiltration / Q000502:physiology*; D009504:Neutrophils / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000950:Antigens, Ly; D039481:CD11b Antigen; D039521:CD11c Antigen; C480309:Ly6G antigen, mouse