title: Acute and 90-day subchronic toxicity studies of Silk peptide E5K6, in Sprague-Dawley rats.
abstract: Acute and 90-day subchronic oral toxicity studies of Silk peptide E5K6 were performed in Sprague-Dawley rats. In the acute toxicity study, Silk peptide E5K6 was administered orally to male and female rats at a single dose of 2000 and 5000 mg/kg. Mortality, clinical signs and body weight changes were monitored for 14 days. There were no treatment-related changes in these parameters. Therefore, the Approximate Lethal Dose (ALD) of Silk peptide E5K6 in male and female rats is higher than 5000 mg/kg. In the subchronic toxicity study, Silk peptide E5K6 was administered orally to male and female rats for 90 days at a single dose of 500, 1000, and 2000 mg/kg. There were no toxicologically significant changes in clinical signs, body weight, food and water consumptions, ophthalmoscopic examination, urinalysis, hematological and serum biochemical examinations, necropsy findings, organ weights and histopathological examination of all of the animals treated with Silk peptide E5K6. These results suggest that the oral No Observed Adverse-Effect Level (NOAEL) of Silk peptide E5K6 is greater than 2000 mg/kg/day in both sexes and the target organs were not established.
authors: Preclinical Research Center, ChemOn Inc., 334 Jeil-ri, Yangji-myeon, Cheoin-gu, Yongin-si, Gyeonggi-do 449-826, Republic of Korea.
authors: Zhong-Ze
authors: ZZ
authors: Han
authors: Kyo-Hwan
authors: KH
authors: Koo
authors: Kwang-Ho
authors: KH
authors: Kim
authors: Jin-Sook
authors: JS
authors: Bae
authors: Seo-Ho
authors: SH
authors: Shin
authors: Hak-Soo
authors: HS
authors: Kim
authors: Ji-Hoon
authors: JH
authors: Kim
authors: Hyun-Suk
authors: HS
authors: Heo
authors: Ki-Hyun
authors: KH
authors: Gil
authors: Joo-Young
authors: JY
authors: Lee
authors: Kap-Ho
authors: KH
authors: Kim
authors: Boo-Hyon
authors: BH
authors: Kang
authors: Hyun-Kul
authors: HK
authors: Lee
authors: Ho-Young
authors: HY
authors: Choi
authors: Yong-Chun
authors: YC
authors: Li
authors: Seong-Ho
authors: SH
authors: Yeon
authors: Jeong-Yong
authors: JY
authors: Lee
authors: Si-Whan
authors: SW
authors: Song
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D019476:Insect Proteins / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D047011:Silk / Q000737:chemistry*
chemical_list: D019476:Insect Proteins; D047011:Silk