title: Integration of detailed modules in a core model of body fluid homeostasis and blood pressure regulation.
abstract: This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative physiology. A formalization of the model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton model, a multi-organ, integrated systems model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin-angiotensin system. Simulation results of the extended integrated model are presented and the impacts of their integration within the original model are evaluated.
authors: INSERM U642, Rennes F-35000, France. Alfredo.Hernandez@inserm.fr
authors: Alfredo I
authors: AI
authors: Hernández
authors: Virginie
authors: V
authors: Le Rolle
authors: David
authors: D
authors: Ojeda
authors: Pierre
authors: P
authors: Baconnier
authors: Julie
authors: J
authors: Fontecave-Jallon
authors: François
authors: F
authors: Guillaud
authors: Thibault
authors: T
authors: Grosse
authors: Robert G
authors: RG
authors: Moss
authors: Patrick
authors: P
authors: Hannaert
authors: S Randall
authors: SR
authors: Thomas
mesh_terms: D001775:Blood Circulation / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D001826:Body Fluids / Q000502:physiology*; D004703:Endocrine System / Q000502:physiology; D006321:Heart / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology; D008954:Models, Biological; D012084:Renin-Angiotensin System / Q000502:physiology; D018511:Systems Integration