title: Neuroglobin expression in human arteriovenous malformation and intracerebral hemorrhage.
abstract: We reported previously that Notch signaling is activated in human arteriovenous malformations (AVMs) and that intracerebral hemorrhage (ICH) in humans is accompanied by increased neurogenesis. The former phenomenon may be involved in AVM pathogenesis and the latter in the brain's response to ICH-induced injury. Here we describe increased expression of the hypoxia-inducible neuroprotective protein, neuroglobin (Ngb), in neurons surrounding unruptured AVMs and in the perihematomal region adjacent to ICH. In these disorders, as in other clinical settings, such as ischemic stroke, AVM- and ICH-induced overexpression of Ngb may be stimulated by ischemic hypoxia and may help to constrain brain injury.
authors: Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.
authors: Kunlin
authors: K
authors: Jin
authors: XiaoOu
authors: X
authors: Mao
authors: Lin
authors: L
authors: Xie
authors: David A
authors: DA
authors: Greenberg
mesh_terms: D001165:Arteriovenous Malformations / Q000378:metabolism / Q000473:pathology*; D001921:Brain / Q000378:metabolism*; D002543:Cerebral Hemorrhage / Q000378:metabolism / Q000473:pathology*; D005786:Gene Expression Regulation / Q000502:physiology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005914:Globins / Q000378:metabolism*; D006801:Humans; D007211:Indoles; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000078787:Neuroglobin; D010751:Phosphopyruvate Hydratase / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D007211:Indoles; D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; C007293:DAPI; D005914:Globins; D010751:Phosphopyruvate Hydratase