title: Discovery of new eunicellins from an Indonesian octocoral Cladiella sp.
abstract: Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (-)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors: Yung-Husan
authors: YH
authors: Chen
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors: Chia-Ying
authors: CY
authors: Tai
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Yin-Di
authors: YD
authors: Su
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.
authors: Yu-Chia
authors: YC
authors: Chang
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors: Mei-Chin
authors: MC
authors: Lu
authors: Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
authors: Ching-Feng
authors: CF
authors: Weng
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Jui-Hsin
authors: JH
authors: Su
authors: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
authors: Tsong-Long
authors: 0000-0002-5780-3977
authors: TL
authors: Hwang
authors: Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.|Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan.
authors: Yang-Chang
authors: YC
authors: Wu
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.|Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Ping-Jyun
authors: 0000-0002-6644-9236
authors: PJ
authors: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007214:Indonesia; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D010196:Pancreatic Elastase / Q000378:metabolism; D013057:Spectrum Analysis / Q000379:methods; D013481:Superoxides / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; C476503:eunicellin; D013481:Superoxides; D010196:Pancreatic Elastase