title: [Necrobiosis lipoidica. Variants on a theme].
abstract: A 69-year-old patient presented with different skin lesions all of which belonged to group of necrobiosis lipoidica. The initial histologic diagnosis was actinic granuloma O'Brien. A subsequent biopsy was interpreted as granulomatous necrobiosis lipoidica. The history of these necrobiotic variants is reviewed and exemplarily depicted with this case. Necrobiosis lipoidica is part of the spectrum of granulomatous skin disorders. Although its etiology is unclear, an association with diabetes mellitus is often discussed. Multiple therapeutic options exist, but standardized guidelines for treatment are missing.
authors: Universitäts-Hautklinik, Universitätsklinikum Freiburg, Freiburg i. Br. eva.geissler@uniklinik-freiburg.de
authors: E
authors: E
authors: Geissler
authors: H
authors: H
authors: Laaff
authors: K
authors: K
authors: Technau
authors: L
authors: L
authors: Bruckner-Tuderman
authors: D
authors: D
authors: Nashan
mesh_terms: D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006101:Granuloma, Giant Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D055623:Keratosis, Actinic / Q000175:diagnosis* / Q000473:pathology; D009335:Necrobiosis Lipoidica / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology