title: Chiral phosphoric acid catalyzed transfer hydrogenation: facile synthetic access to highly optically active trifluoromethylated amines.
abstract: Amines to an end: highly optically active α-CF(3)-functionalized amines can be obtained using metal-free reaction conditions. The method involves the transfer hydrogenation of CF(3)-substituted ketimines catalyzed by 1 and reductive amination of CF(3)-substituted ketones. The synthetic utility of this method was demonstrated by the synthesis of a CF(3) analogue of NPS R-568. PMP=para-methoxyphenyl.
authors: Department of Chemistry, Gakushuin University, Mejiro, Toshima-ku, Tokyo, Japan.
authors: Alexander
authors: A
authors: Henseler
authors: Masanori
authors: M
authors: Kato
authors: Keiji
authors: K
authors: Mori
authors: Takahiko
authors: T
authors: Akiyama
mesh_terms: D000586:Amination; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D005461:Fluorine / Q000737:chemistry; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D010084:Oxidation-Reduction; D010756:Phosphoric Acids / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007097:Imines; D009570:Nitriles; D010756:Phosphoric Acids; C542835:ketimine; D005461:Fluorine; C030242:phosphoric acid