title: EGFR expression in advanced head and neck cutaneous squamous cell carcinoma.
abstract: BACKGROUND
  The significance of epidermal growth factor receptor (EGFR) expression in advanced cutaneous squamous cell carcinoma (SCC) of the head and neck remains poorly understood.
  
  
  METHODS
  We performed a retrospective review of patients with advanced-stage (stage III or stage IV) cutaneous SCC of the head and neck (n = 56).
  
  
  RESULTS
  The majority of patients (91%) had stage III disease, with 54% having regional metastasis and 9% with distant metastasis. Two-year survival was 64% and the 5-year survival was 56%. EGFR was found to be overexpressed in 56% of primary tumors and 58% of regional metastatic disease. Overall survival did not correlate with EGFR (p = .47) expression in primary lesions, nor was it associated with an increase in regional (p = .74) or distant metastasis (p = .56). Furthermore, there was no correlation between clinicopathologic characteristics and EGFR expression
  
  
  CONCLUSIONS
  These data do not suggest upregulation of EGFR is associated with poor survival or aggressive disease.
authors: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors: Larissa
authors: L
authors: Sweeny
authors: Nichole R
authors: NR
authors: Dean
authors: J Scott
authors: JS
authors: Magnuson
authors: William R
authors: WR
authors: Carroll
authors: Emily E
authors: EE
authors: Helman
authors: Stephen O
authors: SO
authors: Hyde
authors: Renee L
authors: RL
authors: Desmond
authors: Eben L
authors: EL
authors: Rosenthal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology / Q000628:therapy
chemical_list: D066246:ErbB Receptors