title: Case report of a poorly differentiated uterine tumour with t(10;17) translocation and neuroectodermal phenotype.
abstract: Endometrial stromal sarcoma (ESS) with primitive neuroectodermal differentiation is a very uncommon entity. Such a case presenting as stage IIIc (International Federation of Gynaecology and Obstetrics (FIGO) 2010) disease in a 51-year-old female is described. Microscopy suggested a small blue round cell tumour. Cytogenetic and multicolour fluorescent in situ hybridisation (M-FISH) analysis revealed a complex karyotype with the presence of unbalanced t(10;17)(q22;p13) translocation, indicating ESS. Peripheral Ewing´s sarcoma was excluded based on FISH and RT-PCR fusion transcripts analysis. After surgical staging, the patient received bleomycin-etoposide-cisplatin combination chemotherapy. A detailed analysis of the histopathology and genetic findings forms the basis of this report.
authors: Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, and Department of Human Genetics, Catholic University of Leuven, Herestraat 49, B-3000 Leuven, Belgium. frederic.amant@uz.kuleuven.ac.be
authors: Frédéric
authors: F
authors: Amant
authors: Thomas
authors: T
authors: Tousseyn
authors: Lieve
authors: L
authors: Coenegrachts
authors: Jan
authors: J
authors: Decloedt
authors: Philippe
authors: P
authors: Moerman
authors: Maria
authors: M
authors: Debiec-Rychter
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D002454:Cell Differentiation / Q000502:physiology; D002879:Chromosomes, Human, Pair 10; D002886:Chromosomes, Human, Pair 17; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D017599:Neuroectodermal Tumors / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D010641:Phenotype; D018203:Sarcoma, Endometrial Stromal / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin