title: Von Willebrand factor, and soluble intercellular and vascular cell adhesion molecules as indices of endothelial activation in patients with congenital hypothyroidism.
abstract: Considering the high prevalence of congenital hypothyroidism (CH) in Isfahan, the possible involvement of endothelial dysfunction in the pathogenesis of CH and the lack of studies in this field, the aim of this study was to determine the endothelial function in CH patients.
  
  
  METHODS
  During this case-control study, the endothelial function in CH neonates and in those with normal screening results was evaluated during a CH screening program in Isfahan. Peripheral blood samples were obtained for measurement of the von Willebrand factor (vWf), and intercellular and vascular cell adhesion molecule (ICAM and VCAM). In CH patients these biomarkers were measured twice: before and 4 weeks after treatment.
  
  
  RESULTS
  In this study, 56 neonates were evaluated: 30 of them were neonates with normal screening results and 26 were diagnosed with CH and classified into two groups according to their TSH levels. The mean ICAM and VCAM were higher in CH patients than in the control group (p < 0.05). The mean ICAM and VCAM decreased significantly after treatment in CH patients (p < 0.05). There is no significant relationship between TSH, ICAM, VCAM and vWf (p > 0.05).
  
  
  CONCLUSIONS
  The findings of this study demonstrate the possible involvement of the endothelial system in the pathogenesis of CH and its cardiovascular complications. Further studies with a larger sample size and with the measurement of other endothelial function markers are needed.
authors: Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mahin
authors: M
authors: Hashemipour
authors: Elham Hashemi
authors: EH
authors: Dehkordi
authors: Shaghayegh Haghjooy
authors: SH
authors: Javanmard
authors: Silva
authors: S
authors: Hovsepian
authors: Mohammad Hassan
authors: MH
authors: Moaddab
authors: Roya
authors: R
authors: Kelishadi
authors: Zahra
authors: Z
authors: Aghanouri
authors: Hosein
authors: H
authors: Tavalaian
authors: Mehdi
authors: M
authors: Salekardestani
authors: Massoud
authors: M
authors: Amini
mesh_terms: D016022:Case-Control Studies; D003409:Congenital Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007492:Iran / Q000453:epidemiology; D008297:Male; D015997:Neonatal Screening; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D019010:Vascular Cell Adhesion Molecule-1; D014841:von Willebrand Factor; D018799:Intercellular Adhesion Molecule-1