title: ACR appropriateness criteria(®) on abnormal vaginal bleeding.
abstract: In evaluating a woman with abnormal vaginal bleeding, imaging cannot replace definitive histologic diagnosis but often plays an important role in screening, characterization of structural abnormalities, and directing appropriate patient care. Transvaginal ultrasound (TVUS) is generally the initial imaging modality of choice, with endometrial thickness a well-established predictor of endometrial disease in postmenopausal women. Endometrial thickness measurements of ≤5 mm and ≤4 mm have been advocated as appropriate upper threshold values to reasonably exclude endometrial carcinoma in postmenopausal women with vaginal bleeding; however, the best upper threshold endometrial thickness in the asymptomatic postmenopausal patient remains a subject of debate. Endometrial thickness in a premenopausal patient is a less reliable indicator of endometrial pathology since this may vary widely depending on the phase of menstrual cycle, and an upper threshold value for normal has not been well-established. Transabdominal ultrasound is generally an adjunct to TVUS and is most helpful when TVUS is not feasible or there is poor visualization of the endometrium. Hysterosonography may also allow for better delineation of both the endometrium and focal abnormalities in the endometrial cavity, leading to hysteroscopically directed biopsy or resection. Color and pulsed Doppler may provide additional characterization of a focal endometrial abnormality by demonstrating vascularity. MRI may also serve as an important problem-solving tool if the endometrium cannot be visualized on TVUS and hysterosonography is not possible, as well as for pretreatment planning of patients with suspected endometrial carcinoma. CT is generally not warranted for the evaluation of patients with abnormal bleeding, and an abnormal endometrium incidentally detected on CT should be further evaluated with TVUS.
authors: New York University Medical Center, New York, New York, USA. Genevieve.Bennett@nyumc.org
authors: Genevieve L
authors: GL
authors: Bennett
authors: Rochelle F
authors: RF
authors: Andreotti
authors: Susanna I
authors: SI
authors: Lee
authors: Sandra O
authors: SO
authors: Dejesus Allison
authors: Douglas L
authors: DL
authors: Brown
authors: Theodore
authors: T
authors: Dubinsky
authors: Phyllis
authors: P
authors: Glanc
authors: Donald G
authors: DG
authors: Mitchell
authors: Ann E
authors: AE
authors: Podrasky
authors: Thomas D
authors: TD
authors: Shipp
authors: Cary Lynn
authors: CL
authors: Siegel
authors: Jade J
authors: JJ
authors: Wong-You-Cheong
authors: Carolyn M
authors: CM
authors: Zelop
mesh_terms: D004717:Endometrium / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D011871:Radiology / Q000193:education; D012952:Societies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014481:United States; D014592:Uterine Hemorrhage / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology