title: Therapeutic drug monitoring of clomipramine and amitriptyline in a depressed patient with upper digestive tract resection.
abstract: We describe a 55-year-old woman with extensive digestive resection and recurrent depressive disorder resistant to oral clomipramine tablets but not to an oral solution of amitriptyline. In the light of this case report, the potential mechanisms of drug resistance after digestive resection are discussed, including the importance of drug monitoring.
authors: Service de Psychiatrie Adulte, AP-HP, Hôpital Pitié Salpêtrière, Paris, France.
authors: Pierre-Louis
authors: PL
authors: Couturier
authors: Noël
authors: N
authors: Zahr
authors: Lauriane
authors: L
authors: Goldwirt
authors: Dominique
authors: D
authors: Warot
authors: Jean-François
authors: JF
authors: Allilaire
authors: Simon
authors: S
authors: Lambrey
mesh_terms: D000639:Amitriptyline / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D002997:Clomipramine / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D016903:Drug Monitoring; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008875:Middle Aged; D041742:Upper Gastrointestinal Tract / Q000601:surgery*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D002997:Clomipramine