title: Multivalent glyconanoparticles with enhanced affinity to the anti-viral lectin Cyanovirin-N.
abstract: Low-mannose (LM) structures were coupled to gold nanoparticles (Au NPs) to amplify the affinity of LMs with Cyanovirin-N (CV-N) lectins and to study the structures of CV-N variants CVN(Q50C) and CVN(MutDB).
authors: Department of Chemistry, Portland State University, P.O. Box 751, Portland, Oregon, 97207-0751, USA.
authors: Xin
authors: X
authors: Wang
authors: Elena
authors: E
authors: Matei
authors: Lingquan
authors: L
authors: Deng
authors: Olof
authors: O
authors: Ramström
authors: Angela M
authors: AM
authors: Gronenborn
authors: Mingdi
authors: M
authors: Yan
mesh_terms: D019943:Amino Acid Substitution; D000998:Antiviral Agents / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D002151:Calorimetry; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006046:Gold / Q000737:chemistry; D037102:Lectins / Q000737:chemistry; D008358:Mannose / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D011485:Protein Binding
chemical_list: D000998:Antiviral Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D037102:Lectins; C107733:cyanovirin N; D006046:Gold; D008358:Mannose