title: The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins.
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lienhai Road, Kaohsiung 80424, Taiwan. ccliaw@mail.nsysu.edu.tw
authors: Chih-Chuang
authors: CC
authors: Liaw
authors: Wen-Ying
authors: WY
authors: Liao
authors: Chien-Sheng
authors: CS
authors: Chen
authors: Shu-Chuan
authors: SC
authors: Jao
authors: Yang-Chang
authors: YC
authors: Wu
authors: Chia-Ning
authors: CN
authors: Shen
authors: Shih-Hsiung
authors: SH
authors: Wu
mesh_terms: D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002118:Calcium / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D008954:Models, Biological; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D054378:Acetogenins; D000970:Antineoplastic Agents; D002614:Chelating Agents; D005663:Furans; D009942:Organometallic Compounds; C018674:tetrahydrofuran; D002118:Calcium