title: Systemic signature of the lung response to respiratory syncytial virus infection.
abstract: Respiratory Syncytial Virus is a frequent cause of severe bronchiolitis in children. To improve our understanding of systemic host responses to RSV, we compared BALB/c mouse gene expression responses at day 1, 2, and 5 during primary RSV infection in lung, bronchial lymph nodes, and blood. We identified a set of 53 interferon-associated and innate immunity genes that give correlated responses in all three murine tissues. Additionally, we identified blood gene signatures that are indicative of acute infection, secondary immune response, and vaccine-enhanced disease, respectively. Eosinophil-associated ribonucleases were characteristic for the vaccine-enhanced disease blood signature. These results indicate that it may be possible to distinguish protective and unfavorable patient lung responses via blood diagnostics.
authors: Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. Jeroen.Pennings@rivm.nl
authors: Jeroen L A
authors: JL
authors: Pennings
authors: Annemieke
authors: A
authors: Schuurhof
authors: Hennie M
authors: HM
authors: Hodemaekers
authors: Annemarie
authors: A
authors: Buisman
authors: Lia C G H
authors: LC
authors: de Rond
authors: Myra N
authors: MN
authors: Widjojoatmodjo
authors: Willem
authors: W
authors: Luytjes
authors: Jan L L
authors: JL
authors: Kimpen
authors: Louis
authors: L
authors: Bont
authors: Riny
authors: R
authors: Janssen
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D008168:Lung / Q000378:metabolism* / Q000821:virology*; D008198:Lymph Nodes / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D018357:Respiratory Syncytial Virus Infections / Q000097:blood* / Q000235:genetics* / Q000276:immunology / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000502:physiology*; D014611:Vaccination