title: Decrease of insulin growth factor-1 as a novel mechanism for anti-androgen effect of isotretinoin and its reported association with depression in some cases.
abstract: Isotretinoin and its desirable effects have received tremendous attention in recent years by scientists. This article reviews the evidence that decrease of insulin growth factor-1 is implicated as a novel mechanism of anti androgenic effect and its reported association with depression in some cases.
authors: Department of Dermatology, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors: Amir
authors: A
authors: Feily
authors: Mohammad R
authors: MR
authors: Namazi
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000726:Androgen Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D003863:Depression / Q000139:chemically induced* / Q000378:metabolism*; D003879:Dermatologic Agents / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D015474:Isotretinoin / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D000726:Androgen Antagonists; D003879:Dermatologic Agents; D007334:Insulin-Like Growth Factor I; D015474:Isotretinoin