title: Nasal extranodal natural killer T cell lymphoma: an atypical presentation.
abstract: OBJECTIVE
  We report two cases of nasal natural killer T cell lymphoma which presented atypically following surgical intervention.
  
  
  METHODS
  Two patients with a previous history of endoscopic nasal surgery presented with progressive facial swelling and necrosis. The histology of several nasal biopsies was suggestive of acute, necrotising inflammation. Considering these patients' midline destruction of the nose and face, and their inconclusive biopsies, immunohistochemical studies were undertaken, enabling the diagnosis of peripheral natural killer T cell lymphoma.
  
  
  CONCLUSIONS
  Natural killer T cell lymphoma of the sinonasal tract is an important differential diagnosis of destructive lesions of the nose and midface. The definitive diagnosis is often delayed. Hence, this tumour should be considered in patients with atypical presentations of acute inflammation following surgical intervention; such patients should be thoroughly investigated. Early immunohistochemical investigation is needed to enable prompt diagnosis in suspicious cases.
authors: Department of Otorhinolaryngology and Head-Neck Services, Seth G S Medical College, King Edward VII Memorial Hospital, Mumbai, India. dr_arpit_sharma@hotmail.com
authors: A
authors: A
authors: Sharma
authors: M
authors: M
authors: Dandekar
authors: S
authors: S
authors: Deshmukh
authors: J
authors: J
authors: Dabholkar
mesh_terms: D000328:Adult; D001706:Biopsy; D003608:Dacryocystorhinostomy; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D016130:Immunophenotyping; D007249:Inflammation / Q000473:pathology; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D059747:Nasal Surgical Procedures / Q000009:adverse effects*; D009336:Necrosis; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D010254:Paranasal Sinus Diseases / Q000175:diagnosis* / Q000473:pathology