title: [Trends of thyroid pathology in a referral center: steady prevalence of papillary thyroid carcinoma but goiter increase in thyroidectomies].
abstract: BACKGROUND
  Changes in the prevalence of papillary thyroid carcinoma (PTC) have been reported in institutions and national cancer registries.
  
  
  OBJECTIVE
  To describe time trends in benign and malignant thyroid diseases in a national endocrine referral center.
  
  
  METHODS
  Systematic review and classification of consecutive specimens with slides/paraffin blocks in surgical pathology archives (January 1990 to December 2009). Institutional registries, size, type of surgery and number of inclusion blocks were recorded. Patients whose registries were granted before January 1990 without nodules, but treated after twelve months for a suspicious thyroid lesion, were included. These patients in a passive follow-up permitted incidence density calculations. Cases were grouped by quinquennium.
  
  
  RESULTS
  Institutional registers were conceded to 103,961 persons worthy of attention, and 1,269 were submitted to thyroidectomies (1.2%). One hundred twenty four patients none treated for thyroid diseases before 1990, developed thyroid nodules after 1991. The incidence density for goiter was 0.05 person/year and for PTC 0.04 person/year in that group. In all series woman to man relation was 9:1 with a mean age of 45 years. Total or near total thyroidectomies were performed in 60% patients and benign diseases were diagnosed in 732 (52%) cases. Thyroid surgeries increased since 2005 (p=0.03) with a rise in goiter prevalence (0.25, 0.31, 0.35, 0.38, p for trend 0.0005), without significant increase in PTC prevalence (0.41, 0.43, 0.35, 0.40, p for trend 0.71) in thyroidectomies.
  
  
  CONCLUSIONS
  Goiter as the only finding in thyroid specimens increased 52% in the last 20 years. PTC prevalence is steady with a higher number of tumors<3 cm.
authors: Departamento de Patología y Clínica de Tiroides, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Mexico. agamboad@gmail.com
authors: Armando
authors: A
authors: Gamboa-Domínguez
authors: Saúl
authors: S
authors: Lino-Silva
authors: Fernando
authors: F
authors: Candanedo-González
authors: Erla
authors: E
authors: Medina-López
authors: Denise
authors: D
authors: Acuña-González
authors: Iván
authors: I
authors: Jacinto-Cortés
authors: Ofelia
authors: O
authors: González-Treviño
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000453:epidemiology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006042:Goiter / Q000453:epidemiology* / Q000601:surgery; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D015995:Prevalence; D012017:Referral and Consultation; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000453:epidemiology*; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D016606:Thyroid Nodule / Q000453:epidemiology / Q000601:surgery; D013965:Thyroidectomy / Q000706:statistics & numerical data*; D047368:Tumor Burden; D055815:Young Adult