title: A new salicylic acid-derivatized kojic acid vanadyl complex: synthesis, characterization and anti-diabetic therapeutic potential.
abstract: The molecular mechanisms of vanadium toxicity suggest that incorporation of antioxidant groups in the structure of vanadium complexes could be a preferable strategy in designing novel hypoglycemic vanadium complexes with proper efficacy and safety. By conjugating a pyrone skeleton to provide a coordination group and antioxidative motifs, we synthesized a novel complex of bis ((5-hydroxy-4-oxo-4H-pyran-2-yl) methyl 2-hydroxy- benzoatato) oxovanadium (IV) (BSOV). Evaluation of the anti-diabetic effects of BSOV using streptozotocin (STZ)-induced diabetic rats with bis (maltolato) oxovanadium (BMOV) as a positive control showed that BSOV effectively lowered blood glucose level, ameliorated damages of hepatic and renal function in diabetic rats and improved lipid metabolism. The signs of potential alteration of renal function caused by BSOV and BMOV were observed and are discussed. Overall, the experimental results suggest BSOV as a potent hypoglycemic agent and further studies using this strategy for anti-diabetic agents.
authors: State Key Laboratories of Natural and Biomimetic Drugs and Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
authors: Yongbiao
authors: Y
authors: Wei
authors: Chengyue
authors: C
authors: Zhang
authors: Pan
authors: P
authors: Zhao
authors: Xiaoda
authors: X
authors: Yang
authors: Kui
authors: K
authors: Wang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011753:Pyrones / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020156:Salicylic Acid / Q000737:chemistry*; D014638:Vanadates / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D056831:Coordination Complexes; D007004:Hypoglycemic Agents; D011753:Pyrones; C562058:bis((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl 2-hydroxybenzoatato)oxovanadium(IV); D014638:Vanadates; C011890:kojic acid; D020156:Salicylic Acid