title: Contrast agents possessing high temperature sensitivity.
abstract: Contrast agents based on lanthanide tetra-propargyl DOTAM complexes suitable for temperature mapping by magnetic resonance spectroscopy (MRS) are reported. Sensitivity values from 1.05 ppm/°C to 1.76 ppm/°C were determined which represents an improvement of 2-3 times over currently available lanthanide temperature-responsive contrast agents.
authors: Department of Chemistry, The University of Western Ontario, Ontario, London, Canada N6A 5B7.
authors: Mark
authors: M
authors: Milne
authors: Robert H E
authors: RH
authors: Hudson
mesh_terms: D000081:Acetamides / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D006358:Hot Temperature; D028581:Lanthanoid Series Elements / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: C522450:1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane; D000081:Acetamides; D003287:Contrast Media; D006573:Heterocyclic Compounds, 1-Ring; D028581:Lanthanoid Series Elements