title: Flueggines A and B, two new dimeric indolizidine alkaloids from Flueggea virosa.
abstract: Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, single-crystal X-ray diffraction, and CD analyses. Compound 1 is the first example of Securinega alkaloids bearing an isoxazolidine ring, the plausible biogenetic pathway of which is also proposed. Compound 2 exhibited growth inhibitory activity against MCF-7 and MDA-MB-231 human breast cancer cells.
authors: Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
authors: Bing-Xin
authors: BX
authors: Zhao
authors: Ying
authors: Y
authors: Wang
authors: Dong-Mei
authors: DM
authors: Zhang
authors: Ren-Wang
authors: RW
authors: Jiang
authors: Guo-Cai
authors: GC
authors: Wang
authors: Jun-Min
authors: JM
authors: Shi
authors: Xiao-Jun
authors: XJ
authors: Huang
authors: Wei-Min
authors: WM
authors: Chen
authors: Chun-Tao
authors: CT
authors: Che
authors: Wen-Cai
authors: WC
authors: Ye
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019281:Dimerization; D006801:Humans; D054836:Indolizidines / Q000737:chemistry* / Q000494:pharmacology; D007212:Indolizines / Q000737:chemistry* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D054836:Indolizidines; D007212:Indolizines; C568567:flueggine A; C568568:flueggine B