title: Natural killer cell subsets in man and rodents.
abstract: NK cells are important contributors to the early immune defence against infected or transformed cells. They are rapidly activated in response to cytokines, whereby they exert their effector functions. NK cell responses are controlled by a multitude of receptors, which are expressed by subpopulations of NK cells with distinct phenotypes and functionalities. Direct comparisons between species are often difficult because of differences in the expression of NK cell receptors and other markers. In addition, NK cells change their phenotype and effector functions during differentiation, by tissue-specific factors, or upon activation, complicating interpretations. We will here review the similarities and differences between the major NK cell subsets in man and two well-characterized rodent models.
authors: Department of Immunology, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway. marit.inngjerdingen@rr-research.no
authors: M
authors: M
authors: Inngjerdingen
authors: L
authors: L
authors: Kveberg
authors: C
authors: C
authors: Naper
authors: J T
authors: JT
authors: Vaage
mesh_terms: D000818:Animals; D019002:CD56 Antigen / Q000096:biosynthesis; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002454:Cell Differentiation; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D007694:Killer Cells, Natural / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D010641:Phenotype; D011485:Protein Binding; D051381:Rats
chemical_list: D019002:CD56 Antigen; D015815:Cell Adhesion Molecules; D015395:Histocompatibility Antigens Class I