title: Effect of early postnatal air-conduction auditory deprivation on the development and function of the rat spiral ganglion.
abstract: OBJECTIVE
  To evaluate the effect of early postnatal air-conduction auditory deprivation on the development and function of the rat spiral ganglion.
  
  
  METHODS
  Randomised animal study.
  
  
  METHODS
  Sixty neonatal Sprague-Dawley rats were randomly divided into two groups: controls (n = 30) given regular chow and water ad libitum; and study animals (n = 30) fed within a soundproof chamber. Auditory brainstem response testing was conducted in both groups on postnatal day 42.
  
  
  RESULTS
  Auditory deprivation between postnatal days 12 and 42 resulted in an increased hearing threshold and reduced auditory brainstem response amplitudes, together with degeneration of type I spiral ganglion neurons and the presence of apoptotic cells.
  
  
  CONCLUSIONS
  Non-invasive auditory deprivation during a critical developmental period resulted in numerous changes in rat cochlear function and morphology.
authors: Department of Otolaryngology, General Hospital of Air Force, Beijing, People's Republic of China.
authors: F
authors: F
authors: Wang
authors: X
authors: X
authors: Gao
authors: J
authors: J
authors: Chen
authors: S-L
authors: SL
authors: Liu
authors: F-Y
authors: FY
authors: Wang
authors: R-Y
authors: RY
authors: Hei
authors: Y
authors: Y
authors: Chen
authors: J-H
authors: JH
authors: Qiu
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D017209:Apoptosis; D002452:Cell Count; D003423:Critical Period, Psychological; D004430:Ear Protective Devices; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D006309:Hearing / Q000502:physiology; D020287:In Situ Nick-End Labeling; D008297:Male; D008854:Microscopy, Electron; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012683:Sensory Deprivation; D013136:Spiral Ganglion / Q000254:growth & development* / Q000503:physiopathology / Q000648:ultrastructure; D013194:Staining and Labeling / Q000379:methods
chemical_list: D010751:Phosphopyruvate Hydratase