title: Development and evolution of the human neocortex.
abstract: The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the gyrated human neocortex involves a lineage of neural stem and transit-amplifying cells that forms the outer subventricular zone (OSVZ), a proliferative region outside the ventricular epithelium. We discuss how proliferation of cells within the OSVZ expands the neocortex by increasing neuron number and modifying the trajectory of migrating neurons. Relating these features to other mammalian species and known molecular regulators of the mouse neocortex suggests how this developmental process could have emerged in evolution.
authors: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA.
authors: Jan H
authors: JH
authors: Lui
authors: David V
authors: DV
authors: Hansen
authors: Arnold R
authors: AR
authors: Kriegstein
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002465:Cell Movement; D006801:Humans; D019579:Neocortex / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D058953:Neural Stem Cells / Q000166:cytology; D055495:Neurogenesis; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch