title: Eureka! Ets a target for fibrosis!
abstract: The oncogenic Ets family of transcription factors is now recognized to play a key role in fibroblasts as it controls the expression of a variety of pro-fibrotic genes, including the induction of CCN2 by transforming growth factor β. A recent report (Baran et al., Am J Respir Cell Mol Biol. 2011 May 11) shows that mice containing a version of ets2 that is incapable of being phosphorylated are resistant to bleomycin-induced lung fibrosis. This latter paper is the subject of this commentary.
authors: Department of Dentistry, Dental Sciences Building, University of Western Ontario, London, ON, Canada, N6A 5C1, Andrew.leask@schulich.uwo.ca.
authors: Andrew
authors: A
authors: Leask