title: Moderate noise induced cognition impairment of mice and its underlying mechanisms.
abstract: Noise pollution is recognized as a serious human health problem in modern society. The aim of the present study was to explore the effects of moderate-intensity white noise exposure on learning and memory of mice, and the underlying mechanisms. The learning and memory ability of mice were evaluated by water maze and step-down inhibitory avoidance experiments respectively, following 1, 3, and 6 weeks noise exposure (80 dB SPL, 2h/day). To explore potential mechanisms, we determined levels of oxidative stress in the inferior colliculus (IC), auditory cortex (AC), and hippocampus (the structures comprising the critical encephalic region associated with the acoustic lemniscal ascending pathway), the phosphorylation of microtubule-associated protein tau in the hippocampus (important role in learning and memory), and the basic auditory response properties of neurons in the IC. Moderate-intensity noise exposure impaired the learning and memory ability of mice in both water maze and step-down inhibitory avoidance experiments, and the longer the noise exposure time the greater the impairment. At 6 weeks after noise exposure, there was also evidence of oxidative damage in the IC, AC, and hippocampus, hyperphosphorylated tau protein in the hippocampus, and significant changes in the auditory response properties of neurons in the IC. These data results suggest that moderate-intensity noise can progressively impair the learning and memory ability of mice, which may result from peroxidative damage, tau hyperphosphorylation, and auditory coding alteration.
authors: College of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, PR China.
authors: Liang
authors: L
authors: Cheng
authors: Shao-Hui
authors: SH
authors: Wang
authors: Qi-Cai
authors: QC
authors: Chen
authors: Xiao-Mei
authors: XM
authors: Liao
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001303:Auditory Cortex; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology; D006624:Hippocampus / Q000378:metabolism; D007245:Inferior Colliculi / Q000378:metabolism; D008297:Male; D018782:Maze Learning; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000378:metabolism; D009622:Noise / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D000072105:Superoxide Dismutase-1; D013550:Swimming; D013997:Time Factors; D016875:tau Proteins / Q000378:metabolism
chemical_list: C000606290:SOD1 protein, human; D016875:tau Proteins; C000606291:Sod1 protein, mouse; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D018817:N-Methyl-3,4-methylenedioxyamphetamine