title: Synthesis and characterization of hierarchically macroporous and mesoporous CaO-MO-SiO(2)-P(2)O(5) (M=Mg, Zn, Sr) bioactive glass scaffolds.
abstract: Mg-, Zn- and Sr-doped hierarchically macroporous and mesoporous CaO-MO-SiO(2)-P(2)O(5) (M=Mg, Zn or Sr) bioactive glass (HMMBG) scaffolds were synthesized using the non-ionic block copolymer EO(20)PO(70)EO(20) and polyurethane sponges as cotemplates. The Mg-, Zn- or Sr-doped HMMBG scaffolds showed no distinct difference in phase composition, macroporous structure or pore volume from the HMMBG scaffolds without Mg, Zn or Sr. The Mg-, Zn- and Sr-doped HMMBG scaffolds showed no cytotoxicity. The gradual release of Ca, P, Si, Mg, Zn and Sr into the culture medium from these scaffolds contributed to the enhancement of the proliferation and ALP activity of mesenchymal stem cells (MSCs). The Mg-, Zn- and Sr-doped HMMBG scaffolds may be used as bone substitute materials.
authors: Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology, Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. xp-wang@aist.go.jp
authors: Xiupeng
authors: X
authors: Wang
authors: Xia
authors: X
authors: Li
authors: Atsuo
authors: A
authors: Ito
authors: Yu
authors: Y
authors: Sogo
mesh_terms: D000327:Adsorption / Q000187:drug effects; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003470:Culture Media / Q000737:chemistry; D005898:Glass / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D009584:Nitrogen / Q000737:chemistry; D010087:Oxides / Q000138:chemical synthesis* / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D003470:Culture Media; D010087:Oxides; D000469:Alkaline Phosphatase; D009584:Nitrogen