title: Effects of nutritional supplementation on periodontal parameters, carotenoid antioxidant levels, and serum C-reactive protein.
abstract: Few studies have focused on the role of nutrition in periodontal disease. The purpose of this trial was to determine the effect of a nutritional supplement on gingival inflammation, bleeding, probing depth, clinical attachment level, carotenoid antioxidant level, and C-reactive protein. The test supplement, consisting of a standard multivitamin formula, as well as several phytonutrients associated with antiinflammatory/antioxidant effects, provided modest benefits in reducing inflammation; however, further studies with larger populations and longer intervention are warranted.
authors: Department of Periodontics, Arthur A. Dugoni School of Dentistry, San Francisco, California 94115, USA.
authors: Lisa A
authors: LA
authors: Harpenau
authors: Abida T
authors: AT
authors: Cheema
authors: Joseph A
authors: JA
authors: Zingale
authors: David W
authors: DW
authors: Chambers
authors: William P
authors: WP
authors: Lundergan
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002338:Carotenoids / Q000032:analysis; D019587:Dietary Supplements; D005260:Female; D005891:Gingivitis / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D010512:Periodontal Index; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D008903:Minerals; D010936:Plant Extracts; D014815:Vitamins; D002338:Carotenoids; D002097:C-Reactive Protein