title: New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis.
abstract: Five new isoprenylated flavonoids, notabilisins A-E (1-5), and two known Diels-Alder adducts (6 and 7), were isolated from the twigs of Morus notabilis. Compounds 4 and 5 possess two novel pyran rings, which may be biogenetically derived from 3. Compounds 1 and 3 significantly promoted adipogenesis, characterized by increased lipid droplet and triglyceride content in 3T3L1 cells, and induced up-regulation of the expression of adipocyte-specific genes, aP2 and GLUT4.
authors: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
authors: Xiao
authors: X
authors: Hu
authors: Jun
authors: J
authors: Ji
authors: Meng
authors: M
authors: Wang
authors: Jin-Wei
authors: JW
authors: Wu
authors: Qin-Shi
authors: QS
authors: Zhao
authors: He-Yao
authors: HY
authors: Wang
authors: Ai-Jun
authors: AJ
authors: Hou
mesh_terms: D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D002460:Cell Line; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051275:Glucose Transporter Type 4 / Q000235:genetics / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D031625:Morus / Q000737:chemistry*; D054876:Prenylation
chemical_list: C493411:Fabp4 protein, mouse; D050556:Fatty Acid-Binding Proteins; D005419:Flavonoids; D051275:Glucose Transporter Type 4; C495692:SLC2A4 protein, human