title: CDC/NIH Workshop. Tuberculosis biomarker and surrogate endpoint research roadmap.
abstract: The Centers for Disease Control and Prevention and National Institutes of Health convened a multidisciplinary meeting to discuss surrogate markers of treatment response in tuberculosis. The goals were to assess recent surrogate marker research and to provide specific recommendations for (1) the qualification and validation of biomarkers of treatment outcome; (2) the standardization of specimen and data collection for future clinical trials, including a minimum set of samples and collection time points; and (3) the creation ofa specimen repository to support biomarker testing. This article summarizes these recommendations and provides a roadmap for their implementation.
authors: Division of Pulmonary and Critical Care, Curry International Tuberculosis Center, San Francisco General Hospital, University of California-San Francisco, CA 94110, USA. pnahid@ucsf.edu
authors: Payam
authors: P
authors: Nahid
authors: Jussi
authors: J
authors: Saukkonen
authors: William R
authors: WR
authors: Mac Kenzie
authors: John L
authors: JL
authors: Johnson
authors: Patrick P J
authors: PP
authors: Phillips
authors: Janet
authors: J
authors: Andersen
authors: Erin
authors: E
authors: Bliven-Sizemore
authors: John T
authors: JT
authors: Belisle
authors: W Henry
authors: WH
authors: Boom
authors: Annie
authors: A
authors: Luetkemeyer
authors: Thomas B
authors: TB
authors: Campbell
authors: Kathleen D
authors: KD
authors: Eisenach
authors: Richard
authors: R
authors: Hafner
authors: Jeffrey L
authors: JL
authors: Lennox
authors: Mamodikoe
authors: M
authors: Makhene
authors: Susan
authors: S
authors: Swindells
authors: M Elsa
authors: ME
authors: Villarino
authors: Marc
authors: M
authors: Weiner
authors: Constance
authors: C
authors: Benson
authors: William
authors: W
authors: Burman
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D018070:Biological Specimen Banks; D015415:Biomarkers / Q000032:analysis* / Q000378:metabolism; D002986:Clinical Trials as Topic / Q000592:standards*; D006801:Humans; D013048:Specimen Handling / Q000592:standards*; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D000995:Antitubercular Agents; D015415:Biomarkers