title: Synthesis of L-epi-capreomycidine derivatives via C-H amination.
abstract: The L-epi-capreomycidine (Cpm) derivatives were efficiently and stereoselectively synthesized via nitrene C-H insertion starting from a readily available D-Tyr. Design of a substrate that takes into account hydrogen bonding is a critical feature in order to achieve high selectivity. Our synthetic strategy could be a new access to epi-Cpm and its derivatives, which are found in several biologically active natural products.
authors: Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6,Sapporo 060-0812, Japan.
authors: Tetsuya
authors: T
authors: Tanino
authors: Satoshi
authors: S
authors: Ichikawa
authors: Akira
authors: A
authors: Matsuda
mesh_terms: D000586:Amination; D001120:Arginine / Q000031:analogs & derivatives* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: C463580:capreomycidine; D002244:Carbon; D006859:Hydrogen; D001120:Arginine