title: Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp.
abstract: Three new depsipeptides, fijimycins A-C (1-3), together with the known etamycin A (4), were isolated and identified from the fermentation broth of strain CNS-575, a Streptomyces sp. cultured from a marine sediment sample collected off Nasese, Fiji. The planar structures of the new fijimycins were assigned by combined interpretation of NMR and MS/MS spectroscopic data. These assignments were complicated by the fact that 1-3 occurred as complex amide conformational mixtures. The absolute configurations of the component amino acids were established using the Marfey's method. Fijimycins A-C, and etamycin A, were shown to possess significant in vitro antibacterial activity against three methicillin-resistant Staphylococcus aureus (MRSA) strains with MIC(100) values between 4 and 16 μg mL(-1).
authors: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204, USA.
authors: Peng
authors: P
authors: Sun
authors: Katherine N
authors: KN
authors: Maloney
authors: Sang-Jip
authors: SJ
authors: Nam
authors: Nina M
authors: NM
authors: Haste
authors: Ritesh
authors: R
authors: Raju
authors: William
authors: W
authors: Aalbersberg
authors: Paul R
authors: PR
authors: Jensen
authors: Victor
authors: V
authors: Nizet
authors: Mary E
authors: ME
authors: Hensler
authors: William
authors: W
authors: Fenical
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism* / Q000494:pharmacology; D047630:Depsipeptides / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005367:Fiji; D018942:Macrolides / Q000737:chemistry; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism*; D053719:Tandem Mass Spectrometry
chemical_list: D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D018942:Macrolides; C004910:etamycin