title: Bioadhesive film formed from a novel organic-inorganic hybrid gel for transdermal drug delivery system.
abstract: A novel organic-inorganic hybrid film-forming agent for TDDS was developed by a modified poly(vinyl alcohol) (PVA) gel using γ-(glycidyloxypropyl)trimethoxysilane (GPTMS) as an inorganic-modifying agent, poly(N-vinyl pyrrolidone) (PVP) as a tackifier and glycerol (GLY) as a plasticizer. The prepared gels can be applied to the skin by a coating method and in situ form very thin and transparent films with good performance, comfortable feel and cosmetic attractiveness. The key properties of the bioadhesive films produced from the hybrid gels were investigated and the results showed that the incorporation of appropriate GPTMS (GPTMS/(PVA+GPTMS) in the range of 20-30%) into the PVA matrix not only can significantly enhance mechanical strength and skin adhesion properties of the resultant film, but also can decrease the crystalline regions of PVA and hence facilitate the diffusion of water vapor and drug. Furthermore, the investigations into in vivo skin irritation suggested the films caused non-irritation to skin after topical application for 120 h. In conclusion, the bioadhesive films formed from organic-inorganic hybrid gels possessed very good qualities for application on the skin and may provide a promising formulation for TDDS, especially when the patient acceptability from an aesthetic perspective of the dosage form is a prime consideration.
authors: Department of Polymer Science and Technology, Tianjin University, Tianjin, China.
authors: Ruiwei
authors: R
authors: Guo
authors: Xiaoyan
authors: X
authors: Du
authors: Rui
authors: R
authors: Zhang
authors: Liandong
authors: L
authors: Deng
authors: Anjie
authors: A
authors: Dong
authors: Jianhua
authors: J
authors: Zhang
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000378:metabolism; D005782:Gels; D005990:Glycerol / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D008855:Microscopy, Electron, Scanning; D011142:Polyvinyl Alcohol / Q000737:chemistry* / Q000633:toxicity; D011205:Povidone / Q000737:chemistry* / Q000633:toxicity; D012821:Silanes / Q000737:chemistry* / Q000633:toxicity; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012869:Skin Absorption; D023422:Skin Irritancy Tests; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014014:Tissue Adhesives / Q000737:chemistry* / Q000633:toxicity; D014783:Viscosity; D014961:X-Ray Diffraction; D055815:Young Adult
chemical_list: D004337:Drug Carriers; D005782:Gels; D012821:Silanes; D014014:Tissue Adhesives; C069686:gamma-glycidoxypropyltriethoxysilane; D011142:Polyvinyl Alcohol; D011205:Povidone; D005990:Glycerol; D005472:Fluorouracil; D007052:Ibuprofen