title: Duloxetine in the treatment of binge eating disorder with depressive disorders: a placebo-controlled trial.
abstract: OBJECTIVE
  This study evaluated duloxetine in the treatment of binge eating disorder (BED) with comorbid current depressive disorders.
  
  
  METHODS
  In this 12-week, double-blind, placebo-controlled trial, 40 patients with Diagnostic and Statistical Manual of Mental Disorders-IV-TR BED and a comorbid current depressive disorder received duloxetine (N = 20) or placebo (N = 20). The primary outcome measure was weekly binge eating day frequency.
  
  
  RESULTS
  In the primary analysis, duloxetine (mean 78.7 mg/day) was superior to placebo in reducing weekly frequency of binge eating days (p = .04), binge eating episodes (p = .02), weight (p = .04), and Clinical Global Impression-Severity of Illness ratings for binge eating (p = .02) and depressive disorders (p = .01). Changes in body mass index and measures of eating pathology, depression, and anxiety did not differ between the two groups.
  
  
  CONCLUSIONS
  Duloxetine may be effective for reducing binge eating, weight, and global severity of illness in BED with a comorbid current depressive disorder, but this finding needs confirmation in larger, placebo-controlled trials.
authors: Lindner Center of HOPE, Mason, OH, USA. anna.guerdjikova@lindnercenter.org
authors: Anna I
authors: AI
authors: Guerdjikova
authors: Susan L
authors: SL
authors: McElroy
authors: Erin L
authors: EL
authors: Winstanley
authors: Eric B
authors: EB
authors: Nelson
authors: Nicole
authors: N
authors: Mori
authors: Jessica
authors: J
authors: McCoy
authors: Paul E
authors: PE
authors: Keck
authors: James I
authors: JI
authors: Hudson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D056912:Binge-Eating Disorder / Q000150:complications / Q000188:drug therapy*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy*; D004311:Double-Blind Method; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013876:Thiophenes / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride