title: Acute respiratory distress syndrome caused by miliary tuberculosis: a multicentre survey in South Korea.
abstract: BACKGROUND
  Miliary tuberculosis (TB) is an unusual cause of acute respiratory distress syndrome (ARDS).
  
  
  OBJECTIVE
  To evaluate the clinical characteristics and outcomes of patients with ARDS caused by miliary TB admitted to the intensive care unit (ICU).
  
  
  METHODS
  A total of 67 patients were enrolled during the period 1999-2008.
  
  
  RESULTS
  The median age of the patients was 56 years (range 17-81), 19 (28.4%) were aged >71 years, and 38 (56.7%) were male. All-cause mortality in the ICU and hospital were respectively 58.2% and 61.2%. Of the total number of enrolled patients, 49 (73.1%) were prescribed anti-tuberculosis medication within 3 days of hospital admission. On the day of ARDS diagnosis (10.0 ± 3.7 vs. 7.4 ± 3.5, P = 0.005), non-survivors had a significantly higher Sequential Organ Failure Assessment (SOFA) score than survivors. Multivariate analysis showed that SOFA score on the day of ARDS diagnosis was a significant predictor of survival (OR 0.809, 95%CI 0.691-0.946, P = 0.008). It was difficult to determine the efficacy of systemic corticosteroids on patient survival.
  
  
  CONCLUSIONS
  ARDS caused by miliary TB was associated with a high in-hospital mortality rate, with SOFA score on the day of ARDS diagnosis being a valuable prognostic indicator.
authors: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors: K
authors: K
authors: Lee
authors: J H
authors: JH
authors: Kim
authors: J H
authors: JH
authors: Lee
authors: W-Y
authors: WY
authors: Lee
authors: M S
authors: MS
authors: Park
authors: J Y
authors: JY
authors: Kim
authors: K C
authors: KC
authors: Kim
authors: M-G
authors: MG
authors: Lee
authors: K-S
authors: KS
authors: Jung
authors: Y S
authors: YS
authors: Kim
authors: Y M
authors: YM
authors: Shin
authors: Y
authors: Y
authors: Koh
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use; D016009:Chi-Square Distribution; D011307:Drug Prescriptions; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D056910:Republic of Korea / Q000453:epidemiology; D012128:Respiratory Distress Syndrome / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D014391:Tuberculosis, Miliary / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000995:Antitubercular Agents