title: Evaluation of serum antimullerian hormone and inhibin B concentrations in the differential diagnosis of secondary oligoamenorrhea.
abstract: OBJECTIVE
  To evaluate the performance of antimullerian hormone (AMH) and inhibin B as ovarian function markers for differentiating common causes of secondary oligoamenorrhea, namely hypogonadotrophic hypogonadism (HH), polycystic ovary syndrome (PCOS), premature ovarian failure (POF), and hyperprolactinemia (HPRL).
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  Two university hospitals.
  
  
  METHODS
  A total of 124 women with secondary oligoamenorrhea and 26 women with normal ovulation.
  
  
  METHODS
  Serum samples from the subjects were analyzed for AMH and inhibin B.
  
  
  METHODS
  Serum AMH and inhibin B concentrations.
  
  
  RESULTS
  Serum AMH concentration was significantly raised in women having World Health Organization group 2 anovulation, either with or without PCOS, and was significantly decreased to very low levels in POF; the diagnostic accuracy in both conditions was excellent, with areas under the receiver operating characteristic curve (AUC) of 0.913 and 0.977, respectively. The discriminatory performance between HH and PCOS was also good, with AUC 0.861. AMH remained unchanged in HH and HPRL compared with ovulatory control subjects. There were large overlap of serum inhibin B levels in the different conditions, and a significant difference from control subjects existed only in the POF group.
  
  
  CONCLUSIONS
  Serum AMH, but not inhibin B concentration, serves as a useful diagnostic tool in the differential diagnosis of secondary oligoamenorrhea.
authors: Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong, People's Republic of China. raymondli@hkucc.hku.hk
authors: Hang Wun Raymond
authors: HW
authors: Li
authors: Richard A
authors: RA
authors: Anderson
authors: William Shu Biu
authors: WS
authors: Yeung
authors: Pak Chung
authors: PC
authors: Ho
authors: Ernest Hung Yu
authors: EH
authors: Ng
mesh_terms: D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications / Q000175:diagnosis; D007006:Hypogonadism / Q000097:blood / Q000150:complications / Q000175:diagnosis; D007265:Inhibins / Q000097:blood*; D009839:Oligomenorrhea / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000150:complications / Q000175:diagnosis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers; C422364:inhibin B; D007265:Inhibins; D054304:Anti-Mullerian Hormone