title: Bio-inspired, bioengineered and biomimetic drug delivery carriers.
abstract: Synthetic carriers such as polymer and lipid particles often struggle to meet clinical expectations. Natural particulates - that range from pathogens to mammalian cells - are therefore worth examining in more depth, as they are highly optimized for their specific functions in vivo and possess features that are often desired in drug delivery carriers. With a better understanding of these biological systems, in conjunction with the availability of advanced biotechnology tools that are useful for re-engineering the various natural systems, researchers have started to exploit natural particulates for multiple applications in the delivery of proteins, small interfering RNA and other therapeutic agents. Here, we review the natural drug delivery carriers that have provided the basis and inspiration for new drug delivery systems.
authors: Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA.
authors: Jin-Wook
authors: JW
authors: Yoo
authors: Darrell J
authors: DJ
authors: Irvine
authors: Dennis E
authors: DE
authors: Discher
authors: Samir
authors: S
authors: Mitragotri
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics; D057005:Bioengineering; D040761:Biomimetic Materials; D032701:Biomimetics; D001773:Blood Cells; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013234:Stem Cells; D014612:Vaccines; D058425:Vaccines, Virus-Like Particle; D022701:Virosomes; D014780:Viruses / Q000235:genetics
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D014612:Vaccines; D058425:Vaccines, Virus-Like Particle; D022701:Virosomes