title: Development of disulfide core-crosslinked pluronic nanoparticles as an effective anticancer-drug-delivery system.
abstract: Thiolated Pluronic (Plu-SH) nanoparticles are developed as potential articulate, target-specific anticancer-drug carriers for intracellular drug release triggered by the difference in redox potential in tumor cells. The cores of the micelles are formed by the disulfide bonds of the functionalized Pluronic F127, when dissolved in an aqueous solution. The nanoparticles are 95.6 ± 18.6 nm in size, and 235.6 ± 63.7 nm after encapsulation of the hydrophobic drug molecules. The drug-loaded micelles show effective stability in blood-plasma conditions and the kinetics of micelle stability and drug release are shown. Paclitaxel-loaded micelles display approximately 39% cell viability in A549 cells.
authors: Department of Chemical and Biological Engineering, Chungju National University, Republic of Korea.
authors: Abdullah-Al-Nahain
authors: Haeshin
authors: H
authors: Lee
authors: Young Sun
authors: YS
authors: Lee
authors: Kang Dae
authors: KD
authors: Lee
authors: Sung Young
authors: SY
authors: Park
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D006801:Humans; D008422:Materials Testing; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry* / Q000494:pharmacology; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003432:Cross-Linking Reagents; D004220:Disulfides; D004337:Drug Carriers; D008823:Micelles; D013438:Sulfhydryl Compounds; D013501:Surface-Active Agents; D014867:Water; D020442:Poloxamer; D017239:Paclitaxel