title: Seroresponse to the second measles vaccine dose at school entry in Qassim province, Saudi Arabia.
abstract: In 2001, the measles immunization schedule in Saudi Arabia was changed to 2 measles, mumps and rubella vaccine doses at 12 months and at 6 years. In this follow-up study we evaluated the seroresponse to the second measles dose before school entry. We recruited 138 children randomly from primary health care centres in Qassim; 124 children completed the study. Blood samples were collected before and 1 month after giving the second measles dose, before the age of 6 years. There was a statistically significant increase in the geometric mean titre of measles antibody, from 2205 m IU/mL before vaccination to 4723 mlU/mL after (P = 0.0001). The proportion of children with positive ELISA results increased fro++ 94.2% before vaccination to 99.2% after (P = 0.02), while the proportion with protective level (> or = 200 mlU/mL) increased from 97.1% before vaccination to 99.19% after (P = 0.21). The 2-dose measles immunization schedule can produce optimum protection at school entry if high vaccination coverage is guaranteed.
authors: Department of Communicable Diseases (Vaccinology) & Research Development, Medical Research Administration, Ministry of Health, Riyadh, Saudi Arabia. statkhl@hotmail.com
authors: M K M
authors: MK
authors: Khalil
authors: H M
authors: HM
authors: Nadrah
authors: O A
authors: OA
authors: Al Yahia
authors: G
authors: G
authors: ElGhazali
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008457:Measles / Q000097:blood / Q000276:immunology* / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D012529:Saudi Arabia; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine