title: Early myocardial deformation changes associated to isolated obesity: a study based on 3D-wall motion tracking analysis.
abstract: Obesity is considered as a strong risk factor for cardiovascular morbidity and mortality. 3D-wall motion tracking echocardiography (3D-WMT) provides information regarding different parameters of left ventricular (LV) myocardial deformation. Our aim was to assess the presence of early myocardial deformation abnormalities in nonselected obese children free from other cardiovascular risk factors. Thirty consecutive nonselected obese children and 42 healthy volunteer children were enrolled. None of them had any cardiovascular risk factor. Every subject underwent a 2D-echo examination and a 3D-WMT study. Mean age was 13.9 ± 2.56 and 13.25 ± 2.68 years in the nonobese and obese groups, respectively (59.7% and 40.3% male). Statistically significant differences were found for: interventricular septum thickness, LV posterior wall thickness, LV end-diastolic volume, LV end-systolic volume, left atrium volume, LV mass, and lateral annulus peak velocity. Regarding the results obtained by 3D-WMT assessment, all the evaluated parameters were statistically significantly different between the two groups. When the influence of obesity on the different echocardiographic variables was evaluated by means of multivariate logistic regression analysis, the strongest relationship with obesity was found for LV average circumferential strain (β-coefficient: 0.74; r(2): 0.55; P: 0.003). Thus, obesity cardiomyopathy is associated not only with structural cardiac changes, but also with myocardial deformation changes. Furthermore, this association occurs as early as in the childhood and it is independent from any other cardiovascular risk factor. The most related parameter to obesity is LV circumferential strain.
authors: Cardiology Department, Hospital Clínico San Carlos, Madrid, Spain.
authors: Adriana
authors: A
authors: Saltijeral
authors: Leopoldo Pérez de
authors: LP
authors: Isla
authors: Olga
authors: O
authors: Pérez-Rodríguez
authors: Santiago
authors: S
authors: Rueda
authors: Covadonga
authors: C
authors: Fernandez-Golfin
authors: Carlos
authors: C
authors: Almeria
authors: Jose L
authors: JL
authors: Rodrigo
authors: Willem
authors: W
authors: Gorissen
authors: Juan
authors: J
authors: Rementeria
authors: Pedro
authors: P
authors: Marcos-Alberca
authors: Carlos
authors: C
authors: Macaya
authors: Jose
authors: J
authors: Zamorano
mesh_terms: D000293:Adolescent; D009202:Cardiomyopathies / Q000150:complications / Q000000981:diagnostic imaging; D002318:Cardiovascular Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D002648:Child; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009206:Myocardium / Q000473:pathology; D009765:Obesity / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011446:Prospective Studies; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology