title: Role of reactive oxygen species in the early stages of liver regeneration in streptozotocin-induced diabetic rats.
abstract: Diabetes mellitus is a risk factor for prognosis after liver resection. In previous work, we found a pro-apoptotic state in the diabetic rat liver. In this work, this was also observed 1 hour post-partial hepatectomy (PH) and resulted in a deficient regenerative response 24 hours post-PH. Treatment with insulin and/or Desferoxamine (DES) (iron chelator) or Tempol (TEM) (free radicals scavenger) was effective in preventing the liver reactive oxygen species (ROS) production induced by diabetic state. High levels of ROS play a role in hepatic lipid peroxidation in diabetes before and after PH, and lead to increased pro-apoptotic events, which contribute to a reduced regenerative response. This becomes of relevance for the potential use of antioxidants/free radical scavengers plus insulin for improvement of post-surgical recovery of diabetic patients subjected to a PH.
authors: Instituto de Fisiología Experimental (IFISE-CONICET), Suipacha 570, 2000 Rosario, Argentina.
authors: Daniel E
authors: DE
authors: Francés
authors: María T
authors: MT
authors: Ronco
authors: Paola I
authors: PI
authors: Ingaramo
authors: Juan A
authors: JA
authors: Monti
authors: Gerardo B
authors: GB
authors: Pisani
authors: Juan P
authors: JP
authors: Parody
authors: José M
authors: JM
authors: Pellegrino
authors: María C
authors: MC
authors: Carrillo
authors: Paloma
authors: P
authors: Martín-Sanz
authors: Cristina E
authors: CE
authors: Carnovale
mesh_terms: D000818:Animals; D003497:Cyclic N-Oxides / Q000494:pharmacology; D003676:Deferoxamine / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D006498:Hepatectomy; D007328:Insulin / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D008115:Liver Regeneration / Q000502:physiology*; D011379:Prognosis; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013113:Spin Labels; D013311:Streptozocin
chemical_list: D003497:Cyclic N-Oxides; D007328:Insulin; D017382:Reactive Oxygen Species; D013113:Spin Labels; D013311:Streptozocin; D003676:Deferoxamine; C001803:tempol