title: Dysembryoplastic neuroepithelial tumor and calcifying pseudoneoplasms of the neuraxis: a collision of two seizure-associated lesions.
abstract: Dysembryoplastic neuroepithelial tumor (DNET) is a benign glioneuronal neoplasm typically associated with intractable, partial complex seizures in children and young adults. The authors present a case in which a DNET in a 45-year-old male was accompanied by a so-called "calcifying pseudoneoplasm of the neural axis" (CPNA), a rare tumefactive lesion considered reactive in nature. An MRI scan of the brain revealed a right temporal lobe abnormality with characteristics of DNT but no apparent calcification. Histologically, it exhibited classic features of DNET and an overlying meningeal- based, partially ossified, chondrocalcific lesion morphologically characteristic of CPNA. The association of DNET and CPNA has not been previously reported. The literature relevant to these two seizure-associated lesions is reviewed.
authors: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
authors: X
authors: X
authors: Yan
authors: W R
authors: WR
authors: Marsh
authors: B W
authors: BW
authors: Scheithauer
mesh_terms: D001932:Brain Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D002114:Calcinosis / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D015897:Comorbidity; D003399:Craniotomy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D018302:Neoplasms, Neuroepithelial / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D013724:Teratoma / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome