title: Low Mannose-Binding Lectin (MBL) genotype is associated with future cardiovascular events in type 2 diabetic South Asians. A prospective cohort study.
abstract: BACKGROUND
  South Asians have a high burden of type 2 diabetes and vascular complications. Vascular inflammation is considered central in the pathophysiology of atherosclerosis, and the complement system is thought to play an important role. Mannose-Binding Lectin (MBL), which activates the lectin pathway of complement activation, has been introduced as a risk marker of vascular damage. The present study explores the association of MBL levels, genotype and cardiovascular events in type 2 diabetic South Asians.
  
  
  METHODS
  We conducted a prospective observational study. A cohort consisting of 168 type 2 diabetic South Asians was followed for a median duration of 7.66 years. At baseline, MBL levels and genotype were determined. The association with future cardiovascular events was assessed by Cox proportional hazard regression.
  
  
  RESULTS
  During follow-up, 31 cardiovascular events occurred in 22 subjects (11 men, 11 women). The O/O genotype was significantly associated with the occurrence of cardiovascular events (hazard ratio 3.42, 95%CI 1.24-9.49, P = 0.018). However, log MBL levels were not associated with the occurrence of cardiovascular events (hazard ratio 0.93, 95% CI 0.50-1.73).
  
  
  CONCLUSIONS
  In type 2 diabetic South Asians, the O/O MBL genotype is associated with cardiovascular events, although single serum MBL levels are not.
authors: Department of Nephrology, Leiden University Medical Center, the Netherlands. m.a.siezenga@lumc.nl
authors: Machiel A
authors: MA
authors: Siezenga
authors: Prataap K Chandie
authors: PK
authors: Shaw
authors: Mohamed R
authors: MR
authors: Daha
authors: Ton J
authors: TJ
authors: Rabelink
authors: Stefan P
authors: SP
authors: Berger
mesh_terms: D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D001210:Asia, Southeastern / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000208:ethnology* / Q000235:genetics; D015331:Cohort Studies; D003165:Complement System Proteins / Q000378:metabolism; D001026:Coronary Artery Bypass; D016757:Death, Sudden, Cardiac / Q000453:epidemiology / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D011446:Prospective Studies
chemical_list: D037601:Mannose-Binding Lectin; D003165:Complement System Proteins