title: Flavans from Iris tenuifolia and their effects on β-amyloid aggregation and neural stem cells proliferation in vitro.
abstract: Two new flavans (1, 2) and a new flavanone (3), together with three known compounds (4-6), were isolated from the roots of Iris tenuifolia. Their structures were elucidated by means of spectroscopic methods including 1D and 2D NMR techniques and mass spectrometry. Compounds 1, 4, and 6 were further confirmed by single-crystal X-ray diffraction analysis. Biological evaluation showed that compounds 1 and 4 were positive in inhibiting β-amyloid (Aβ) aggregation and promoting neural stem cells (NSCs) proliferation, respectively.
authors: Key Laboratory for Cell Proliferation and Regulation Biology, Beijing Key Laboratory of Gene Engineering Drugs and Biological Technology, College of Life Sciences, Beijing Normal University, Beijing, PR China.
authors: Yan-Mei
authors: YM
authors: Cui
authors: Hui
authors: H
authors: Wang
authors: Quan-Ru
authors: QR
authors: Liu
authors: Mei
authors: M
authors: Han
authors: Yang
authors: Y
authors: Lu
authors: Chang-Qi
authors: CQ
authors: Zhao
mesh_terms: D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D049109:Cell Proliferation; D018360:Crystallography, X-Ray; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D031323:Iris Plant / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D058953:Neural Stem Cells / Q000187:drug effects*; D018517:Plant Roots / Q000737:chemistry
chemical_list: C562331:3'-hydroxy-5,7-dimethoxy-4-O-2'-cycloflavan; D016229:Amyloid beta-Peptides; D005419:Flavonoids