title: High kurtosis of intracranial electroencephalogram as a marker of ictogenicity in pediatric epilepsy surgery.
abstract: OBJECTIVE
  We determined whether kurtosis analysis of intracranial electroencephalogram (EEG) can estimate the localization of the epileptogenic zone.
  
  
  METHODS
  We analyzed 29 pediatric epilepsy patients who underwent intracranial EEG before focal resective surgery. We localized the brain regions with high kurtosis, the seizure onset zone (SOZ) and the regions with high-rate, high-amplitude and long-duration interictal paroxysms ≥20 Hz. We tested correlations between the surgical resection of those regions and post-surgical seizure outcome, and correlations between kurtosis and the rate/amplitude/duration of interictal paroxysms.
  
  
  RESULTS
  The resection of the regions with high kurtosis correlated with 1-year post-surgical seizure outcome (p=0.028) but not with 2-year outcome. Kurtosis showed more significant correlation with 1-year seizure outcome than the SOZ and the rate/amplitude/duration of interictal paroxysms. Kurtosis showed positive, independent correlations with the amplitude and duration of interictal paroxysms (p<0.0001) but not with the rate (p=0.4).
  
  
  CONCLUSIONS
  The regions with high kurtosis provide more reliable information to predict seizure outcome than the SOZ and the regions with high-rate/amplitude and long-duration interictal paroxysms. Kurtosis reflects combined effects of the amplitude and duration of the interictal paroxysms.
  
  
  CONCLUSIONS
  High kurtosis suggests the regions with acquired ictogenicity within the irritative zone.
authors: Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
authors: Tomoyuki
authors: T
authors: Akiyama
authors: Makoto
authors: M
authors: Osada
authors: Masahide
authors: M
authors: Isowa
authors: Cristina Y
authors: CY
authors: Go
authors: Ayako
authors: A
authors: Ochi
authors: Irene M
authors: IM
authors: Elliott
authors: Mari
authors: M
authors: Akiyama
authors: O Carter
authors: OC
authors: Snead
authors: James T
authors: JT
authors: Rutka
authors: James M
authors: JM
authors: Drake
authors: Hiroshi
authors: H
authors: Otsubo
mesh_terms: D000293:Adolescent; D001921:Brain / Q000503:physiopathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome