title: Meltable dextran esters as biocompatible and functional coating materials.
abstract: The conversion of dextran with in situ synthesized iminium chlorides of long chain carboxylic acids was used to obtain pure and defined melting dextran esters in an efficient one-pot synthesis. The melting point of these esters can be tailored by the degree of substitutions (DS), the molecular weight of the starting polymer, and the chain length of the ester moiety. The dextran esters give homogeneous and completely transparent melts, which form stable films on a broad variety of materials. Even complex geometries, such as implants, can be evenly coated by multiple melting steps. The films do not display any inhomogeneity and have a very low surface roughness. Therefore, no unspecific protein binding is observed. Moreover, the dextran esters are biocompatible as demonstrated for the interaction with three types of cells namely human brain microvascular endothelial cell, primary human fibroblasts, and mouse myoblast cells.
authors: Institute of Organic Chemistry and Macromolecular Chemistry, Center of Excellence for Polysaccharide Research, Friedrich Schiller University of Jena, Humboldtstr. 10, 07743 Jena, Germany.
authors: Tim
authors: T
authors: Liebert
authors: Jana
authors: J
authors: Wotschadlo
authors: Peggy
authors: P
authors: Laudeley
authors: Thomas
authors: T
authors: Heinze
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002152:Calorimetry, Differential Scanning; D002478:Cells, Cultured; D003911:Dextrans / Q000737:chemistry*; D004952:Esters; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D003911:Dextrans; D004952:Esters