title: Variation in clinical presentation and genotype of causative Leishmania major strain in cutaneous leishmaniasis in north and south Afghanistan.
abstract: A different clinical picture and therapeutic response were observed when data from Leishmania major-infected Dutch military personnel stationed in southern (N = 8) and northern (N = 169) Afghanistan were analyzed. Clinical presentation of cutaneous leishmaniasis in personnel in the south was milder and seemed to respond better to antileishmanial treatment; molecular analyses of parasite isolates seem to indicate that these differences may be genetic.
authors: Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS and Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. p.p.vanthiel@amc.uva.nl
authors: Pieter-Paul A M
authors: PP
authors: van Thiel
authors: Tom
authors: T
authors: van Gool
authors: William R
authors: WR
authors: Faber
authors: Tjalling
authors: T
authors: Leenstra
authors: Piet A
authors: PA
authors: Kager
authors: Aldert
authors: A
authors: Bart
mesh_terms: D000346:Afghanistan; D005838:Genotype; D006801:Humans; D018320:Leishmania major / Q000472:pathogenicity*; D016773:Leishmaniasis, Cutaneous / Q000469:parasitology*