title: A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo.
abstract: Mechanisms underlying experience-dependent refinement of cortical connections, especially GABAergic inhibitory circuits, are unknown. By using a line of mutant mice that lack activity-dependent BDNF expression (bdnf-KIV), we show that experience regulation of cortical GABAergic network is mediated by activity-driven BDNF expression. Levels of endogenous BDNF protein in the barrel cortex are strongly regulated by sensory inputs from whiskers. There is a severe alteration of excitation and inhibition balance in the barrel cortex of bdnf-KIV mice as a result of reduced inhibitory but not excitatory conductance. Within the inhibitory circuits, the mutant barrel cortex exhibits significantly reduced levels of GABA release only from the parvalbumin-expressing fast-spiking (FS) interneurons, but not other interneuron subtypes. Postnatal deprivation of sensory inputs markedly decreased perisomatic inhibition selectively from FS cells in wild-type but not bdnf-KIV mice. These results suggest that postnatal experience, through activity-driven BDNF expression, controls cortical development by regulating FS cell-mediated perisomatic inhibition in vivo.
authors: Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA.
authors: Yuanyuan
authors: Y
authors: Jiao
authors: Zhi
authors: Z
authors: Zhang
authors: Chunzhao
authors: C
authors: Zhang
authors: Xinjun
authors: X
authors: Wang
authors: Kazuko
authors: K
authors: Sakata
authors: Bai
authors: B
authors: Lu
authors: Qian-Quan
authors: QQ
authors: Sun
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D015153:Blotting, Western; D019208:Brain-Derived Neurotrophic Factor / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D003433:Crosses, Genetic; D055879:Gene Knock-In Techniques; D007150:Immunohistochemistry; D007395:Interneurons / Q000378:metabolism*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008959:Models, Neurological; D019579:Neocortex / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D005680:gamma-Aminobutyric Acid