title: [Prospects for the use of histaminergic preparations for the purpose of noise otoprotection].
abstract: The objective of the present study was to experimentally evaluate the otoprotective effect of the histaminergic preparation betagistin dihydrochloride given at a dose of 32 mg to 10 healthy male volunteers aged from 18 to 22 (mean 19.4) years who were exposed to 85 dB "white" nose for 1 hour. The functional state of their auditory system was estimated from the results of investigations including determination of the tonal auditory threshold, delayed evoked otoacoustic emission and distortion-product frequency otoacoustic emission, short-latency evoked auditory potentials, and extratympanic electrocochleography. It was shown that betagistin dihydrochloride produced a well-apparent otoprotective effect over the entire range of tests comprehensively characterizing the functional state of the cochlea. It is concluded that betagistin dihydrochloride has good prospects for the application in a variety of production activities (to treat occupational noise-induced pathology) including aerospace medicine.
authors: E I
authors: EI
authors: Matsnev
authors: E E
authors: EE
authors: Sigaleva
mesh_terms: D000293:Adolescent; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology; D001621:Betahistine / Q000494:pharmacology*; D005500:Follow-Up Studies; D006317:Hearing Loss, Noise-Induced / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D017442:Histamine Agonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009623:Noise, Occupational / Q000009:adverse effects*; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects / Q000502:physiology; D011379:Prognosis; D012016:Reference Values; D055815:Young Adult
chemical_list: D017442:Histamine Agonists; D001621:Betahistine