title: Screening for cervical and breast cancer among women with inflammatory bowel disease: a population-based study.
abstract: BACKGROUND
  There are limited data on rates and predictors of cervical and/or breast cancer screening among women with inflammatory bowel disease (IBD). Immunosuppressant medications used to manage IBD may increase the risk of cervical cancer precursor lesions.
  
  
  METHODS
  Women diagnosed with IBD prior to 2002 were matched to up to 10 Manitoba residents without the disease. Logistic regression analyses were performed to compare utilization of Papanicolaou (Pap) tests and mammograms in the two groups. Among women with IBD, we analyzed the differences in screening between those with and without exposure to immunosuppressant medications and/or corticosteroids and effect of age, socioeconomic status, prior diagnostic testing, and intensity of healthcare utilization.
  
  
  RESULTS
  In all, 54% of the 2344 women with IBD and 52% of the 15,333 controls had regular Pap tests between 2002 and 2008. In multivariate analyses, older age, lower socioeconomic status, lower intensity of healthcare utilization, Crohn's disease, and exposure to immunosuppressant medications were independent predictors of lower use of Pap testing. Although there were no significant differences in the use of mammograms in women with or without IBD or among women with IBD with or without exposure to immunosuppressant medications, only 47% of women with IBD in the target age group had mammograms regularly.
  
  
  CONCLUSIONS
  Despite a need for higher testing, women with IBD on immunosuppressant medications are less likely to undergo Pap testing. Healthcare providers involved in the care of women with IBD need to remind these individuals about regular preventive care.
authors: Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. singh@cc.umanitoba.ca
authors: Harminder
authors: H
authors: Singh
authors: Zoann
authors: Z
authors: Nugent
authors: Alain A
authors: AA
authors: Demers
authors: Charles N
authors: CN
authors: Bernstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis*; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D055088:Early Detection of Cancer / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016015:Logistic Models; D008327:Mammography / Q000706:statistics & numerical data*; D008350:Manitoba; D008875:Middle Aged; D065006:Papanicolaou Test; D012959:Socioeconomic Factors; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents