title: Management of recurrent pterygium with intraoperative mitomycin C and conjunctival autograft with fibrin glue.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of using fibrin glue in cases of recurrent pterygium treated with pterygium excision and conjunctival autograft combined with mitomycin C.
  
  
  METHODS
  Retrospective, interventional case series.
  
  
  METHODS
  The charts of 28 patients with recurrent pterygium who had undergone pterygium excision and conjunctival autograft using fibrin glue to secure the graft combined with intraoperative mitomycin C at a corneal service in a university teaching hospital were reviewed. Inclusion criteria were recurrent pterygium that had undergone at least 1 previous surgical excision and patients who had completed a regular postoperative follow-up of at least 12 months. Outcome measures included mean best-corrected visual acuity (BCVA) and intraoperative and postoperative complications.
  
  
  RESULTS
  The mean age of the cohort was 49.7 years. There were no intraoperative complications. Early postoperative total graft dehiscence developed in 1 eye that underwent repositioning with glue and sutures. One eye had mild graft dehiscence and required no surgical intervention. One eye had a conjunctival cyst on the graft that did not require intervention. No significant change was observed in BCVA. At a mean follow-up of 26.5 months, there was 1 case of recurrence.
  
  
  CONCLUSIONS
  Pterygium excision and conjunctival autograft using fibrin glue to secure the graft combined with intraoperative mitomycin C seems to be a safe and effective surgical option for treating recurrent pterygium. However, a larger cohort with longer follow-up may be required to assess the recurrence rate of this method.
authors: Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Canada. raneen_sh_mash@hotmail.com
authors: Raneen
authors: R
authors: Shehadeh-Mashor
authors: Sathish
authors: S
authors: Srinivasan
authors: Corey
authors: C
authors: Boimer
authors: Kenneth
authors: K
authors: Lee
authors: Oren
authors: O
authors: Tomkins
authors: Allan R
authors: AR
authors: Slomovic
mesh_terms: D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000637:transplantation*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007430:Intraoperative Care; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D011183:Postoperative Complications; D011625:Pterygium / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D012008:Recurrence; D012189:Retrospective Studies; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000477:Alkylating Agents; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D016685:Mitomycin