title: Forced expiratory volume in 1 second and cognitive aging in men.
abstract: OBJECTIVE
  To evaluate forced expiratory volume in 1 second (FEV(1) , a measure of overall lung function), long-term average FEV(1) , and rate of decline in FEV(1) in relation to cognition and cognitive decline in older men.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Community-based population.
  
  
  METHODS
  Eight hundred sixty-four older men from the Normative Aging Study.
  
  
  METHODS
  Starting in 1984, participants underwent triennial clinical evaluations. Lung function assessments provided estimates of FEV(1) . Cognitive assessments entailing tests of several cognitive abilities began in 1993. FEV(1) measured approximately 12 years before baseline cognitive testing, average FEV(1) over the 12-year period, and rate of change in FEV(1) were all evaluated in relation to baseline and change in performance on the cognitive tests.
  
  
  RESULTS
  In multivariable-adjusted analyses, associations between FEV(1) and baseline cognitive scores were mixed, although average FEV(1) predicted significantly better performance on tests of visuospatial ability (P=.04) and general cognition (P=.03). Higher FEV(1) was more consistently associated with slower cognitive decline, but only the association between historical FEV(1) and attention was significant (difference per standard deviation in FEV(1) =0.056, P=.05). Rate of FEV(1) decline was not consistently associated with cognitive function or decline. Findings were generally similar or stronger in men who had never smoked. To account for potential bias due to selective attrition, inverse probability of censoring weights were applied to the cognitive decline analyses, yielding slightly larger estimates; the inadequate prognostic power of the censoring models limited this approach.
  
  
  CONCLUSIONS
  Overall, the data provide limited evidence of an inverse association between FEV(1) and cognitive aging.
authors: Department of Internal Medicine, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL 60612, USA. jennifer_weuve@rush.edu
authors: Jennifer
authors: J
authors: Weuve
authors: M Maria
authors: MM
authors: Glymour
authors: Howard
authors: H
authors: Hu
authors: David
authors: D
authors: Sparrow
authors: Avron
authors: A
authors: Spiro
authors: Pantel S
authors: PS
authors: Vokonas
authors: Augusto A
authors: AA
authors: Litonjua
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D008297:Male; D011446:Prospective Studies