title: Plasmacytoma-like post-transplant lymphoproliferative disorder, a rare subtype of monomorphic B-cell post-transplant lymphoproliferation, is associated with a favorable outcome in localized as well as in advanced disease: a prospective analysis of 8 cases.
abstract: Post-transplantation lymphoproliferative disorder (PTLD) with plasmacellular differentiation has been reported as a rare subtype of monomorphic B-cell post-transplant lympho-proliferation with histological and immunophenotypical features of plasmacytoma in the non-transplant population. Here we present clinical, laboratory and histopathological features, treatment and outcome of 8 patients from the German prospective PTLD registry. Clinically, extranodal manifestations were common while osteolytic lesions were rare and none of the patients had bone marrow involvement. Immunohistochemistry showed light chain restriction and expression of CD138 without CD20 expression in all samples. An association with Epstein-Barr virus was found in 3 out of 8 cases. We suggest that the Ann Arbor classification is most useful for this disease entity and report a generally good response to treatment including reduction of immuno-suppression, surgery and irradiation in localized disease and systemic chemotherapy analogous to plasmacell myeloma in advanced disease.
authors: German Study Group on Post-transplant Lymphoproliverative Disorders (DPTLDSG), University Medical Center Schleswig-Holstein, Campus Kiel, Department of Internal Medicine II: Hematology and Oncology, Arnold-Heller Strasse 3, 24105 Kiel, Germany. ralf.trappe@uk-sh.de
authors: Ralf
authors: R
authors: Trappe
authors: Heiner
authors: H
authors: Zimmermann
authors: Susanne
authors: S
authors: Fink
authors: Petra
authors: P
authors: Reinke
authors: Martin
authors: M
authors: Dreyling
authors: Andreas
authors: A
authors: Pascher
authors: Hans
authors: H
authors: Lehmkuhl
authors: Barbara
authors: B
authors: Gärtner
authors: Ioannis
authors: I
authors: Anagnostopoulos
authors: Hanno
authors: H
authors: Riess
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D001402:B-Lymphocytes / Q000378:metabolism* / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis; D005260:Female; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016377:Organ Transplantation / Q000009:adverse effects*; D010954:Plasmacytoma / Q000150:complications / Q000473:pathology* / Q000628:therapy* / Q000821:virology; D019172:Transplantation Conditioning / Q000009:adverse effects; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D004279:DNA, Viral