title: Coupling reaction between electron-rich pyrimidinones and α-amino acids promoted by phosphonium salts.
abstract: Coupling reaction between electron-rich 2-morpholino-4(3H)-pyrimidinone and nucleophilic side chains of several natural α-amino acids promoted by phosphonium salt has been developed to prepare new optically active pyrimidin-4-yl amino acids. The best results were obtained using a two-step method through the easily available benzotriazolyl-1-oxy intermediate. A detailed optimization study of this reaction is discussed.
authors: Department of Chemistry, Faculty of Science, University of Girona, Campus de Montilivi, E-17071, Girona, Spain.
authors: Abdelatif
authors: A
authors: ElMarrouni
authors: Josep M
authors: JM
authors: Fabrellas
authors: Montserrat
authors: M
authors: Heras
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D060172:Morpholinos / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry*; D011744:Pyrimidinones / Q000737:chemistry*; D012492:Salts / Q000737:chemistry
chemical_list: C513120:4(3H)-pyrimidinone; D000596:Amino Acids; D060172:Morpholinos; D063065:Organophosphonates; D011743:Pyrimidines; D011744:Pyrimidinones; D012492:Salts; C030986:pyrimidine