title: Genome-wide association study identifies new prostate cancer susceptibility loci.
abstract: Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P= 4.3 × 10(-8)). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P= 8.6 × 10(-9)). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P= 0.72 and P= 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.
authors: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors: Fredrick R
authors: FR
authors: Schumacher
authors: Sonja I
authors: SI
authors: Berndt
authors: Afshan
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authors: Siddiq
authors: Kevin B
authors: KB
authors: Jacobs
authors: Zhaoming
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authors: Wang
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authors: Lindstrom
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authors: Muir
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authors: Kote-Jarai
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authors: Andriole
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authors: Barricarte
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authors: Bueno-de-Mesquita
authors: E David
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authors: Crawford
authors: W Ryan
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authors: Johansson
authors: Loic
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authors: Le Marchand
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authors: Albanes
authors: Richard B
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authors: Heather Spencer
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authors: Elio
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mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*