title: [External radiation exposure and effective half-life in Lu-177-Dota-Tate therapy].
abstract: The aim of the study was to estimate the external radiation exposure emitted by the patient to his surroundings after discharge. Being in compliance with legal requirements is especially important when doing multiple therapies. To estimate the effective half-life to be used quite realistically, the individual effective half-lives for 41 patients with 52 therapies were calculated. From the resulting histogram the maximum value was determined to be 100 h. Substituting the physical half-life by this maximum effective half-life results in dose estimates, which are lower but still conservative. In addition, the analysis of dose related parameters for patients who underwent multiple therapies demonstrates that the parameters estimated for the first therapy cannot be transferred to the subsequent ones.
authors: Stabsstelle Strahlenschutz und Medizinische Physik, Medizinische Hochschule Hannover, Deutschland.
authors: Jürgen
authors: J
authors: Fitschen
authors: Bernd O
authors: BO
authors: Knoop
authors: Rüdiger
authors: R
authors: Behrendt
authors: Wolfram H
authors: WH
authors: Knapp
authors: Lilli
authors: L
authors: Geworski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001822:Body Burden; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy*; D018358:Neuroendocrine Tumors / Q000532:radiotherapy*; D015282:Octreotide / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods*; D012542:Scattering, Radiation; D055815:Young Adult
chemical_list: D009942:Organometallic Compounds; C447941:lutetium Lu 177 dotatate; D015282:Octreotide