title: Immune modulation of resistance artery remodelling.
abstract: Low-grade inflammation plays a role in cardiovascular disease. The innate and the adaptive immune responses participate in mechanisms that contribute to inflammatory responses. It has been increasingly appreciated that different subsets of lymphocytes and the cytokines they produce modulate the vascular remodelling that occurs in cardiovascular disease. Effector T cells such as T-helper (Th) 1 (interferon-γ-producing) and Th2 lymphocytes (that produce interleukin-4), as well as Th17 (that produce interleukin-17), and T suppressor lymphocytes including regulatory T cells (Treg), which express the transcription factor forkhead box P3 (Foxp3), are involved in the remodelling of small arteries that occurs under the action of angiotensin II, deoxycorticosterone-salt and aldosterone-salt, as well as in models of hypertension such as the Dahl-salt-sensitive rat. The mechanism whereby the immune system is activated is unclear, but it has been suggested that neo-antigens may be generated by the elevation of blood pressure or other stimuli, leading to the activation of the immune response. Activated Th1 may contribute to vascular remodelling directly on blood vessels via effects of the cytokines produced or indirectly by actions on the kidney. The protective effect of Treg may be mediated similarly directly or via renal effects. These data offer promise for the discovery of new therapeutic targets to ameliorate vascular remodelling, which could lead to improved outcome in cardiovascular disease in humans.
authors: Lady Davis Institute for Medical Research, Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, PQ, Canada. ernesto.schiffrin@mcgill.ca
authors: Ernesto L
authors: EL
authors: Schiffrin
mesh_terms: D000818:Animals; D001158:Arteries / Q000033:anatomy & histology / Q000276:immunology / Q000473:pathology; D001160:Arterioles / Q000033:anatomy & histology / Q000276:immunology* / Q000473:pathology*; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D056747:Immunomodulation; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism; D014655:Vascular Resistance
chemical_list: D016207:Cytokines