title: Radiographic changes of the jaws in HbSS and HbSC genotypes of sickle cell disease.
abstract: This study used panoramic radiographs to evaluate the presence of radiographic changes in the jaws of a population who had sickle cell disease (SCD). The authors compared the frequency of findings between subjects with and without SCD. Panoramic radiographs of 71 subjects with SCD (36 with HbSS and 35 with HbSC) and 52 healthy controls (HbAA) were evaluated for the presence of the following radiographic alterations: radiopaque areas, increased spacing of bony trabeculae, horizontal arrangement of bony trabeculae, and absence of mandibular canal corticalization. The control group had a significantly smaller number of all the radiographic features evaluated. Differences were not statistically significant between the groups with HbSS and HbSC, except for more trabecular spacing in the molar region in the HbSS genotype, suggesting a possible correlation between radiographic findings and disease presentation.
authors: Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. fredsampaio@yahoo.com.br
authors: Frederico Sampaio
authors: FS
authors: Neves
authors: Dayane Araújo
authors: DA
authors: de Almeida
authors: Christiano
authors: C
authors: Oliveira-Santos
authors: Jean Nunes
authors: JN
authors: dos Santos
authors: Maria Betânia Pereira
authors: MB
authors: Toralles
authors: Maria Christina Bahiana Olympio
authors: MC
authors: da Silva
authors: Maria Isabela Guimarães
authors: MI
authors: Campos
authors: Iêda
authors: I
authors: Crusoé-Rebello
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000000981:diagnostic imaging*; D015519:Bone Density / Q000502:physiology; D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006450:Hemoglobin SC Disease / Q000000981:diagnostic imaging*; D006451:Hemoglobin, Sickle / Q000235:genetics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007568:Jaw / Q000000981:diagnostic imaging*; D007571:Jaw Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging; D008336:Mandibular Diseases / Q000000981:diagnostic imaging; D008875:Middle Aged; D011862:Radiography, Panoramic / Q000379:methods; D055815:Young Adult
chemical_list: D006451:Hemoglobin, Sickle