title: Synthesis of o-(dimethylamino)aryl ketones and acridones by the reaction of 1,1-dialkylhydrazones and arynes.
abstract: A novel, efficient route to biologically and pharmaceutically important o-(dimethylamino)aryl ketones and acridones has been developed starting from readily available 1,1-dimethylhydrazones of aldehydes and o-(trimethylsilyl)aryl triflates. The reaction proceeds under mild conditions, tolerates a wide range of functional groups, and provides the final products in good to excellent yields.
authors: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors: Anton V
authors: AV
authors: Dubrovskiy
authors: Richard C
authors: RC
authors: Larock
mesh_terms: D054831:Acridones / Q000138:chemical synthesis*; D000478:Alkylation; D000586:Amination; D001389:Azirines / Q000138:chemical synthesis; D006835:Hydrazones / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis*; D008745:Methylation; D015394:Molecular Structure
chemical_list: D054831:Acridones; D001389:Azirines; D006835:Hydrazones; D007659:Ketones