title: Interaction between MMP-9 gene polymorphisms and smoking in relation to myocardial infarction in a Uighur population.
abstract: OBJECTIVE
  Matrix metalloproteinase 9 (MMP-9) plays a pivotal role in early atherosclerosis, vascular remodeling, and development of arterial plaque rupture. The potentially functional MMP-9 gene polymorphism may contribute to the susceptibility of myocardial infarction (MI). We aimed to investigate the association between the interaction of 2 single-nucleotide polymorphisms ([SNPs] -1562C>T and R279Q) of the MMP-9 gene and smoking with MI in a Uighur population of China.
  
  
  METHODS
  A case-control study composed of 384 coronary angiography proven patients with MI and 451 sex-matched and ethnically matched control participants were enrolled in the study. The genotypes of the 2 selected SNPs were determined by the method of polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  Analysis of 2 SNPs, the frequency of -1562 CT and TT genotypes in MI group was significantly higher than in control group (25.52% vs 17.29%; P = .004). And the -1562 T allele showed significant association with MI (MI vs controls: 14.19% vs 9.31%; P = .002). R279Q locus did not show significant differences between patients and controls ( P > .05). Multiple logistic regression analysis showed that -1562 T allele (CT or TT genotype; odds ratio [OR] 1.31, 95% confidence interval [CI] 1.22-1.40; P = .004), the interaction between -1562 T allele and smoking (OR 4.42, 95% CI 2.74-7.13; P < .001), and the interaction between 279 Q allele and smoking (OR 2.07, 95% CI: 1.04-4.13; P = .021) were independent risk factors for MI.
  
  
  CONCLUSIONS
  There findings suggest that MMP-9 -1562C>T polymorphism could be associated with the susceptibility to MI. Another SNP (R279Q) polymorphism was not significantly associated with MI. The -1562C>T or R279Q polymorphism of MMP-9 gene and smoking have a synergistic effect and are significantly associated with the risk of MI in Chinese Uighur population, respectively.
authors: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.
authors: Lei
authors: L
authors: Wang
authors: Yi-Tong
authors: YT
authors: Ma
authors: Xiang
authors: X
authors: Xie
authors: Yi-Ning
authors: YN
authors: Yang
authors: Zhen-Yan
authors: ZY
authors: Fu
authors: Xiao-Mei
authors: XM
authors: Li
authors: Fen
authors: F
authors: Liu
authors: Ying
authors: Y
authors: Huang
authors: Xiang
authors: X
authors: Ma
authors: Bang-Dang
authors: BD
authors: Chen
authors: Shan
authors: S
authors: Yuan
authors: Ming-Hui
authors: MH
authors: Sun
authors: Xiao
authors: X
authors: Peng
authors: Bao-Zhu
authors: BZ
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D017023:Coronary Angiography; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000201:enzymology / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*
chemical_list: D020780:Matrix Metalloproteinase 9