title: Functional capacity of the thyroid autograft and heterograft: An experimental study.
abstract: BACKGROUND
  The aim of this study was to investigate the functional capacity of thyroid autografts/heterografts in a guinea pig model.
  
  
  METHODS
  A total of 24 guinea pigs were divided into 4 groups. Group A had only a thyroidectomy incision, and group B had total thyroidectomy. We performed autotransplantation in group C and heterotransplantation in group D. We monitored the guinea pigs for an 8-week period, with weekly measurements of free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH). At the final stage, the autografts/heterografts were histologically examined.
  
  
  RESULTS
  In group B, fT3/fT4 showed a gradual decrease; however, an increase of TSH was noted. In groups C and D, fT3/fT4 showed a gradual decrease, followed by a gradual increase until euthyroid levels; an exact opposite was noted for TSH. In histologic examination, there were functional thyroid follicles in all animals of groups C and D.
  
  
  CONCLUSIONS
  The autotransplanted/heterotransplanted guinea pig's thyroid tissue provides adequate thyroid function.
authors: Department of Otorhinolaryngology, Ümraniye State Hospital for Research and Training, Istanbul, Turkey. karaman1398@yahoo.com
authors: Murat
authors: M
authors: Karaman
authors: Arzu
authors: A
authors: Tuncel
authors: Shahrouz
authors: S
authors: Sheidaei
authors: Murat Hakan
authors: MH
authors: Karabulut
authors: Arzu
authors: A
authors: Tatlıpınar
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D023421:Models, Animal; D010784:Photomicrography; D013961:Thyroid Gland / Q000473:pathology / Q000502:physiology* / Q000637:transplantation*; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014182:Transplantation, Autologous; D016042:Transplantation, Heterotopic; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine