title: Antibiotic sandwich patch for ventricular septal defect complicated by endocarditis.
abstract: Infective endocarditis in patients with ventricular septal defects can prove life threatening due to acute heart failure or septic embolization. Persistent postoperative risk is bacterial colonization of prosthetic material. We designed the Antibiotic Sandwich Patch to reduce this risk, using a double layer of autologous pericardium containing antibiotic powder. Five patients were managed with this technique for closure of ventricular septal defects complicated by acute infective endocarditis. No colonization of the patches occurred after a median follow up of 1.5 years. This technique reduced the risk of bacterial colonization of the antibiotic sandwich patch, offering an additional surgical option.
authors: Pediatric Cardiac Surgery Unit of Guatemala (UNICARP), Guatemala City, Guatemala. mauro.lorito@gmail.com
authors: Mauro
authors: M
authors: Lo Rito
authors: Juan
authors: J
authors: Leon-Wyss
authors: Oscar
authors: O
authors: Veras
authors: Ivan
authors: I
authors: Vides
authors: Cesar
authors: C
authors: Najera
authors: Aldo R
authors: AR
authors: Castañeda
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002648:Child; D015331:Cohort Studies; D004697:Endocarditis, Bacterial / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D010496:Pericardium / Q000187:drug effects* / Q000637:transplantation*; D011208:Powders; D012189:Retrospective Studies; D018570:Risk Assessment; D055502:Secondary Prevention; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents; D011208:Powders