title: Can G-CSF cause leukemia in hematopoietic stem cell donors?
abstract: A large majority of allogeneic hematopoietic stem cell donations are achieved using granulocyte-colony stimulating factor (G-CSF). G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances. Although clinical data to date have failed to identify any increased incidence of MDS/AML in G-CSF mobilized donors, the quality of these data are insufficient to exclude a long-term risk. Physicians should explain the potential risk to donors, and where appropriate, offer donors the option of marrow donation.
authors: The Ohio State University, Columbus, Ohio, USA.
authors: Belinda R
authors: BR
authors: Avalos
authors: Aleksandr
authors: A
authors: Lazaryan
authors: Edward A
authors: EA
authors: Copelan
mesh_terms: D001800:Blood Specimen Collection / Q000009:adverse effects*; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D014019:Tissue Donors
chemical_list: D016179:Granulocyte Colony-Stimulating Factor