title: Immunotherapy for tauopathies.
abstract: Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach. Studies pioneered by our laboratory and confirmed by others have shown that both active and passive immunizations targeting disease-related tau epitopes successfully reduce tau aggregates in vivo and slow or prevent behavioral impairments in mouse models of tauopathy. Here, we summarize recent advances in this new field.
authors: Department of Physiology and Neuroscience, New York University, School of Medicine, 550 First Avenue, New York, NY 10016, USA.
authors: Jiaping
authors: J
authors: Gu
authors: Einar M
authors: EM
authors: Sigurdsson
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D016874:Neurofibrillary Tangles / Q000473:pathology; D024801:Tauopathies / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D000906:Antibodies; D016875:tau Proteins