title: Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives.
abstract: An N-terminal and C-terminal truncated recombinant α2-6-sialyltransferase cloned from Photobacterium sp. JH-ISH-224, Psp2,6ST(15-501)-His(6), was shown to be an efficient catalyst for one-pot three-enzyme synthesis of sialyl Tn (STn) antigens and derivatives containing natural and non-natural sialic acid forms.
authors: College of Science, Northwest A&F University, Yangling, Shaanxi, China.
authors: Li
authors: L
authors: Ding
authors: Hai
authors: H
authors: Yu
authors: Kam
authors: K
authors: Lau
authors: Yanhong
authors: Y
authors: Li
authors: Saddam
authors: S
authors: Muthana
authors: Junru
authors: J
authors: Wang
authors: Xi
authors: X
authors: Chen
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000096:biosynthesis* / Q000737:chemistry / Q000276:immunology; D055162:Biocatalysis; D006639:Histidine / Q000235:genetics / Q000378:metabolism; D007700:Kinetics; D000216:N-Acylneuraminate Cytidylyltransferase / Q000378:metabolism; D009842:Oligopeptides / Q000235:genetics / Q000378:metabolism; D007652:Oxo-Acid-Lyases / Q000378:metabolism; D010776:Photobacterium / Q000201:enzymology; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D012799:Sialyltransferases / Q000235:genetics / Q000378:metabolism; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C471213:His-His-His-His-His-His; D009842:Oligopeptides; D011994:Recombinant Proteins; C055491:sialosyl-Tn antigen; D006639:Histidine; D012799:Sialyltransferases; D000216:N-Acylneuraminate Cytidylyltransferase; D007652:Oxo-Acid-Lyases; C018728:N-acetylneuraminate lyase; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase