title: Diagnostic evaluation of type 2 (classic) choroidal neovascularization: optical coherence tomography, indocyanine green angiography, and fluorescein angiography.
abstract: OBJECTIVE
  To evaluate the diagnostic characteristics of type 2 (classic) choroidal neovascularizations secondary to age-related macular degeneration using spectral domain-optical coherence tomography (SD OCT), indocyanine green angiography (ICGA), and fluorescein angiography (FA).
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  
  
  
  METHODS
  Institutional.
  
  
  METHODS
  Thirteen treatment-naïve eyes with type 2 choroidal neovascularization without an occult component.
  
  
  METHODS
  Greatest horizontal dimension, based on the anatomic features of the neovascular complex by SD OCT (Spectralis; Heidelberg Engineering), ICGA, and FA; retinal leakage area in late-phase FA and ICGA; and the area of retinal edema in SD OCT.
  
  
  METHODS
  For direct comparison, ICGA and FA images were overlaid manually on infrared plus SD OCT images using VirtualDub and Paint.NET software. Greatest horizontal dimension was measured using Image J software (National Institutes of Health).
  
  
  RESULTS
  The mean greatest horizontal dimension of the neovascular complex and the retinal leakage area consistently were smaller on ICGA compared with the area of retinal edema on SD OCT. According to FA, the greatest horizontal dimension of early, well-demarcated hyperfluorescence was significantly smaller than the neovascular complex on SD OCT. In addition, the greatest horizontal dimension of the retinal leakage area in late-phase FA consistently was smaller than the area of retinal edema on SD OCT.
  
  
  CONCLUSIONS
  In classic choroidal neovascularization, ICGA and FA seem to underestimate the extension of the neovascular complex and the associated retinal pathologic features compared with SD OCT imaging.
authors: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
authors: Florian
authors: F
authors: Sulzbacher
authors: Christopher
authors: C
authors: Kiss
authors: Marion
authors: M
authors: Munk
authors: Gabor
authors: G
authors: Deak
authors: Stefan
authors: S
authors: Sacu
authors: Ursula
authors: U
authors: Schmidt-Erfurth
mesh_terms: D001813:Blood-Retinal Barrier; D002199:Capillary Permeability; D020256:Choroidal Neovascularization / Q000145:classification / Q000175:diagnosis*; D004396:Coloring Agents; D003941:Diagnostic Techniques, Ophthalmological; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D041623:Tomography, Optical Coherence; D057135:Wet Macular Degeneration / Q000175:diagnosis*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green