title: The genotoxic effect of radiofrequency waves on mouse brain.
abstract: Concerns about the health effects of radiofrequency (RF) waves have been raised because of the gradual increase in usage of cell phones, and there are scientific questions and debates about the safety of those instruments in daily life. The aim of this study is to evaluate the genotoxic effects of RF waves in an experimental brain cell culture model. Brain cell cultures of the mice were exposed to 10.715 GHz with specific absorbtion rate (SAR) 0.725 W/kG signals for 6 h in 3 days at 25°C to check for the changes in the micronucleus (MNi) assay and in the expression of 11 proapoptotic and antiapoptotic genes. It was found that MNi rate increased 11-fold and STAT3 expression decreased 7-fold in the cell cultures which were exposed to RF. Cell phones which spread RF may damage DNA and change gene expression in brain cells.
authors: Department of Medical Genetics, Ege University Faculty of Medicine, Izmir, Turkey. emin.karaca@med.ege.edu.tr
authors: Emin
authors: E
authors: Karaca
authors: Burak
authors: B
authors: Durmaz
authors: Huseyin
authors: H
authors: Aktug
authors: Huseyin
authors: H
authors: Altug
authors: Teoman
authors: T
authors: Yildiz
authors: Candan
authors: C
authors: Guducu
authors: Melis
authors: M
authors: Irgi
authors: Mehtap Gulcihan Cinar
authors: MG
authors: Koksal
authors: Ferda
authors: F
authors: Ozkinay
authors: Cumhur
authors: C
authors: Gunduz
authors: Ozgur
authors: O
authors: Cogulu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D001921:Brain / Q000528:radiation effects*; D040421:Cell Phone; D002478:Cells, Cultured; D004249:DNA Damage / Q000528:radiation effects*; D004797:Enzyme-Linked Immunosorbent Assay; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D046228:Microarray Analysis; D015162:Micronucleus Tests; D008872:Microwaves; D012313:RNA / Q000096:biosynthesis / Q000235:genetics; D011846:Radio Waves; D050796:STAT3 Transcription Factor / Q000096:biosynthesis / Q000235:genetics
chemical_list: D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D012313:RNA