title: Organocatalytic hydroacylation of unactivated alkenes.
abstract: N-Heterocyclic carbenes interact with aldehydes to generate the Breslow intermediate, a rendering of the prototypical electrophile into a nucleophile (umpolung). Recent work has indicated that these intermediates may also add to simple, unpolarized alkenes. The use of a chiral precatalyst leads to the generation of the derived adducts with high yields and very high selectivities.
authors: Department of Chemistry, Colorado State University, Fort Collins, 80526, USA.
authors: Daniel A
authors: DA
authors: DiRocco
authors: Tomislav
authors: T
authors: Rovis
mesh_terms: D000215:Acylation; D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000475:Alkenes; D006571:Heterocyclic Compounds; C030011:carbene; D008697:Methane