title: Angiotensin II, oxidative stress and skeletal muscle wasting.
abstract: Muscle atrophy (cachexia) is a muscle wasting syndrome associated with several pathological conditions in humans such as congestive heart failure, diabetes, AIDS, cancer and renal failure, and the presence of cachexia worsens outcome. Many of the conditions associated with cachexia are accompanied by stimulation of the renin-angiotensin system and elevation in angiotensin II (ang II) levels. Ang II infusion induces skeletal muscle atrophy in rodents and mechanisms include increased expression of the E3 ligases atrogin-1/MuRF-1, an elevated rate of ubiquitin-proteasome mediated proteolysis and increased reactive oxygen species (ROS) levels, closely mimicking conditions of human cachexia. Ang II-induced oxidative stress contributes to muscle atrophy in a mouse model. Nicotinamide adenine dinucleotide phosphate oxidase- and mitochondria-derived ROS contribute to ang II-induced oxidative stress. Specific targeting of ROS and nicotinamide adenine dinucleotide phosphate oxidase/mitochondria cross-talk could be a beneficial, novel therapy to treat cachexia.
authors: Tulane University Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA 70112, USA.
authors: Sergiy
authors: S
authors: Sukhanov
authors: Laura
authors: L
authors: Semprun-Prieto
authors: Tadashi
authors: T
authors: Yoshida
authors: A
authors: A
authors: Michael Tabony
authors: Yusuke
authors: Y
authors: Higashi
authors: Sarah
authors: S
authors: Galvez
authors: Patrice
authors: P
authors: Delafontaine
mesh_terms: D000804:Angiotensin II / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D006801:Humans; D051379:Mice; D008931:Mitochondria, Muscle / Q000378:metabolism / Q000502:physiology; D009133:Muscular Atrophy / Q000378:metabolism* / Q000503:physiopathology; D019255:NADPH Oxidases / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000378:metabolism / Q000502:physiology
chemical_list: D017382:Reactive Oxygen Species; D011945:Receptors, Angiotensin; D000804:Angiotensin II; D019255:NADPH Oxidases