title: TP53 Arg72Pro polymorphism in Turkish patients with sporadic amyotrophic lateral sclerosis.
abstract: Recently, Eve et al. (2007) reported that the expression of TP53 (NM_000546) was increased by 2.1-fold in whole spinal cord and 2.7-fold in the ventral horn of amyotrophic lateral sclerosis (ALS) patients. Based on this particular observation, we decided to evaluate whether the TP53 Arg72Pro polymorphism (rs1042522) (C215G) was implicated in the etiopathology of sporadic amyotrophic lateral sclerosis (SALS). Therefore, we genotyped 394 Turkish SALS patients and 439 matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We did not find any association between overall SALS patients with the TP53 Arg72Pro polymorphism and controls (χ(2) = 2.674; p = 0.263). Consequently the TP53 Arg72Pro polymorphism was not associated with SALS.
authors: Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Umuttepe, Kocaeli, Turkey.
authors: Emel
authors: E
authors: Ergul
authors: Mavi Deniz
authors: MD
authors: Ozel
authors: Ali
authors: A
authors: Sazci
authors: Halil Atilla
authors: HA
authors: Idrisoglu
mesh_terms: D000483:Alleles; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D014421:Turkey
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53