title: Importance of clinical variables in the diagnosis of MODY2 and MODY3.
abstract: OBJECTIVE
  MODY (maturity onset diabetes of the young) is a group of well-defined diseases clinically characterised by onset before age 25 years that does not require insulin treatment (at least initially) to prevent the formation of ketone bodies and autosomal dominant inheritance. Despite the importance of accurate classification, it is not always simple to catalogue the diagnosis of a young patient with diabetes, and genetic studies are often improperly used.
  
  
  METHODS
  We describe the clinical features of patients negative for MODY2 and MODY3 and compared them to patients positive for these subtypes.
  
  
  RESULTS
  All patients with MODY3 had been diagnosed before age 25 years and required drug therapy for blood glucose control. MODY2 patients were diagnosed at the first laboratory workup either incidentally or as part of gestational diabetes screening. The clinical description of the 19 patients negative for MODY2 and MODY3 showed that only two patients presented a clinical picture consistent with MODY3 and one patient with MODY2.
  
  
  CONCLUSIONS
  Clinical features can be used for early exclusion of a MODY2 or MODY3 diagnosis and may reduce the need for genetic testing.
authors: Sección de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Albacete, Albacete, España. pjpines@sescam.jccm.es
authors: Pedro J
authors: PJ
authors: Pinés Corrales
authors: M Pilar
authors: MP
authors: López Garrido
authors: Lynda
authors: L
authors: Louhibi Rubio
authors: Silvia
authors: S
authors: Aznar Rodríguez
authors: Luz M
authors: LM
authors: López Jiménez
authors: Cristina
authors: C
authors: Lamas Oliveira
authors: José J
authors: JJ
authors: Lozano García
authors: José J
authors: JJ
authors: Alfaro Martínez
authors: Antonio
authors: A
authors: Hernández López
authors: Ramón
authors: R
authors: Requejo Castillo
authors: Julio
authors: J
authors: Escribano Martínez
authors: Francisco
authors: F
authors: Botella Romero
mesh_terms: D000293:Adolescent; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000145:classification* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult