title: Synthesis and Suzuki-Miyaura cross-coupling reactions of potassium Boc-protected aminomethyltrifluoroborate with aryl and hetaryl halides.
abstract: Potassium Boc-protected aminomethyltrifluoroborate, a primary aminomethyl equivalent, was synthesized successfully through a "one-pot" process. With this trifluoroborate, Suzuki-Miyaura cross-coupling reactions were investigated with a variety of both aryl and hetaryl chlorides in good to excellent yields.
authors: Roy and Diana A. Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA. gmolandr@sas.upenn.edu
authors: Gary A
authors: GA
authors: Molander
authors: Inji
authors: I
authors: Shin
mesh_terms: D000586:Amination; D001888:Boric Acids / Q000138:chemical synthesis*; D019281:Dimerization; D005461:Fluorine / Q000737:chemistry*; D005563:Formic Acid Esters / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D011188:Potassium / Q000737:chemistry*
chemical_list: D001888:Boric Acids; D005563:Formic Acid Esters; D006219:Halogens; C000345:t-butyloxycarbonyl group; D005461:Fluorine; C032688:boric acid; D011188:Potassium