title: Evolutionarily conserved T-cell epitopes on FIV for designing an HIV/AIDS vaccine.
abstract: This review will discuss the current state of the human HIV-1 vaccine trials including the safety consideration of vaccine composition and difficulties in determining and defining protective immunity and epitopes to HIV-1. Vaccines in animal models of lentivirus infection are compared. In particular, the findings from the prototype FIV vaccine and the HIV-1 protein immunizations studies in cats are discussed, as well as the resulting research regarding a potential HIV-1 vaccine design based on evolutionarily conserved T-cell epitopes.
authors: Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, P.O. Box 110880, Gainesville, FL 32611, USA.
authors: J R
authors: JR
authors: Abbott
authors: M P
authors: MP
authors: Sanou
authors: J K
authors: JK
authors: Coleman
authors: J K
authors: JK
authors: Yamamoto
mesh_terms: D016915:AIDS Vaccines / Q000235:genetics* / Q000276:immunology; D000818:Animals; D002415:Cats / Q000821:virology; D002986:Clinical Trials as Topic; D017124:Conserved Sequence / Q000235:genetics; D018604:Epitope Mapping; D018984:Epitopes, T-Lymphocyte / Q000235:genetics*; D015658:HIV Infections / Q000276:immunology; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000235:genetics* / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D018984:Epitopes, T-Lymphocyte; D014614:Vaccines, Synthetic