title: Diorganotin(IV) complexes of biologically potent 4(3H)-quinazolinone derived Schiff bases: synthesis, spectroscopic characterization, DNA interaction studies and antimicrobial activity.
abstract: Four Schiff base ligands and their corresponding organotin(IV) complexes have been synthesized and characterized by elemental analyses, IR, (1)H NMR, MS and thermal studies. The Schiff bases are obtained by the condensation of 3-amino-2-methyl-4(3H)-quinazolinone with different substituted aldehydes. The elemental analysis data suggest the stoichiometry to be 1:1 ratio formation. Infrared spectral data agreed with the coordination to the central metal ion through imine nitrogen, lactam oxygen and deprotonated phenolic oxygen atoms. All the synthesized compounds have been evaluated for antimicrobial activity against selected species of microorganisms. In addition, DNA binding/cleavage capacity of the compounds was analyzed by absorption spectroscopy, viscosity measurements and gel electrophoresis methods.
authors: Department of Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India.
authors: Kollur Shiva
authors: KS
authors: Prasad
authors: Linganna Shiva
authors: LS
authors: Kumar
authors: Shivamallu
authors: S
authors: Chandan
authors: Basvegowda
authors: B
authors: Jayalakshmi
authors: Hosakere D
authors: HD
authors: Revanasiddappa
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D008958:Models, Molecular; D009947:Organotin Compounds / Q000737:chemistry*; D052999:Quinazolinones / Q000737:chemistry*; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013057:Spectrum Analysis / Q000379:methods; D014783:Viscosity
chemical_list: D000890:Anti-Infective Agents; D009947:Organotin Compounds; D052999:Quinazolinones; D012545:Schiff Bases; C061339:4-hydroxyquinazoline; D004247:DNA