title: Genetic profiling of GSTP1, DPYD, FCGR2A, FCGR3A and CCND1 genes in an Argentinian population.
abstract: OBJECTIVE
  To determine the frequencies of relevant allelic variants in oncology for the GSTP1, DPYD, FCGR2A, FCGR3A and CCND1 genes in a population from Central Argentina. To compare the allelic distribution found with the frequencies reported for other ethnic groups.
  
  
  METHODS
  Genotyping was carried out in a total of 102 unrelated Argentinian subjects. FCGR3A (rs396991) was detected using allele specific polymerase chain reaction (PCR) assay, while GSTP1 (rs1695), DPYD (rs3918290), FCGR2A (rs1801274) and CCND1 (rs9344) variants were assessed by PCR-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  The allele frequencies for GSTP*1B, DPYD*2A, FCGR2A (131R), FCGR3A (158F) and CCND1 (870G) in Argentinians were 0.35, 0.005, 0.41, 0.77 and 0.47, respectively.
  
  
  CONCLUSIONS
  We found that the Argentinian population tested resembles other Caucasians populations, especially Spaniards; yet the differences in allele distribution with other Caucasian groups, uncover population admixture with native Amerindian and other ethnic groups, consistent with the well documented immigration flows landing Argentina from several countries.
authors: Laboratorio de Análisis Clínicos Especializados (LACE), Córdoba, Argentina; Cátedra de Biotecnología, Facultad de Ciencias Químicas, Universidad Católica de Córdoba, Córdoba, Argentina.
authors: Cristian A
authors: CA
authors: Galván
authors: Laboratorio de Análisis Clínicos Especializados (LACE), Córdoba, Argentina.
authors: Osvaldo C
authors: OC
authors: Elbarcha
authors: Laboratorio de Análisis Clínicos Especializados (LACE), Córdoba, Argentina.
authors: Eduardo J
authors: EJ
authors: Fernández
authors: Cátedra de Biotecnología, Facultad de Ciencias Químicas, Universidad Católica de Córdoba, Córdoba, Argentina; Centro de Excelencia en Productos y Procesos de Córdoba (CEPROCOR), Santa María de Punilla, Córdoba, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
authors: Dante M
authors: DM
authors: Beltramo
authors: Laboratorio de Análisis Clínicos Especializados (LACE), Córdoba, Argentina; Cátedra de Biotecnología, Facultad de Ciencias Químicas, Universidad Católica de Córdoba, Córdoba, Argentina. Electronic address: nes_soria@yahoo.com.ar.
authors: Néstor W
authors: NW
authors: Soria
mesh_terms: D001118:Argentina / Q000453:epidemiology / Q000208:ethnology; D019938:Cyclin D1 / Q000235:genetics*; D042943:Dihydrouracil Dehydrogenase (NADP) / Q000235:genetics; D004641:Emigration and Immigration; D005006:Ethnicity / Q000235:genetics*; D020869:Gene Expression Profiling; D005787:Gene Frequency; D052138:Genes, Neoplasm; D014644:Genetic Variation; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D044382:Population Groups / Q000235:genetics; D017452:Receptors, IgG / Q000235:genetics*
chemical_list: C530104:CCND1 protein, human; C445323:FCGR2A protein, human; C496124:FCGR3A protein, human; D017452:Receptors, IgG; D019938:Cyclin D1; D042943:Dihydrouracil Dehydrogenase (NADP); C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi