title: Colic in infants.
abstract: BACKGROUND
  Colic in infants causes one in six families (17%) with children to consult a health professional. One systematic review of 15 community-based studies found a wide variation in prevalence, which depended on study design and method of recording.
  
  
  METHODS
  We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for colic in infants? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
  
  
  RESULTS
  We found 27 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
  
  
  CONCLUSIONS
  In this systematic review we present information relating to the effectiveness and safety of the following interventions: advice to increase carrying, advice to reduce stimulation, casein hydrolysate milk, cranial osteopathy, crib vibrator device, focused counselling, gripe water, infant massage, low-lactose milk, simethicone, soya-based infant feeds, spinal manipulation, and whey hydrolysate milk.
authors: Department of General Practice, Radbound University Nijmegen, Nijmegen, The Netherlands.
authors: Peter
authors: P
authors: Lucassen
mesh_terms: D000818:Animals; D003085:Colic / Q000628:therapy; D003448:Crying; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D026301:Manipulation, Osteopathic; D008892:Milk; D012107:Research Design; D012841:Simethicone
chemical_list: D012841:Simethicone