title: The association of unintentional changes in weight, body composition, and homeostasis model assessment index with glycemic progression in non-diabetic healthy subjects.
abstract: BACKGROUND
  We performed a retrospective longitudinal study on the effects of changes in weight, body composition, and homeostasis model assessment (HOMA) indices on glycemic progression in subjects without diabetes during a four-year follow-up period in a community cohort without intentional intervention.
  
  
  METHODS
  From 28,440 non-diabetic subjects who participated in a medical check-up program in 2004, data on anthropometric and metabolic parameters were obtained after four years in 2008. Body composition analyses were performed with a bioelectrical impedance analyzer. Skeletal muscle index (SMI, %) was calculated with lean mass/weight×100. Subjects were divided into three groups according to weight change status in four years: weight loss (≤-5.0%), stable weight (-5.0 to 5.0%), weight gain (≥5.0%). Progressors were defined as the subjects who progressed to impaired fasting glucose or diabetes.
  
  
  RESULTS
  Progressors showed worse baseline metabolic profiles compared with non-progressors. In logistic regression analyses, the increase in changes of HOMA-insulin resistance (HOMA-IR) in four years presented higher odds ratios for glycemic progression compared with other changes during that period. Among the components of body composition, a change in waist-hip ratio was the strongest predictor, and SMI change in four years was a significant negative predictor for glycemic progression. Changes in HOMA β-cell function in four years was a negative predictor for glycemic progression.
  
  
  CONCLUSIONS
  Increased interval changes in HOMA-IR, weight gain and waist-hip ratio was associated with glycemic progression during a four-year period without intentional intervention in non-diabetic Korean subjects.
authors: Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Eun-Jung
authors: EJ
authors: Rhee
authors: Ji-Hun
authors: JH
authors: Choi
authors: Seung-Hyun
authors: SH
authors: Yoo
authors: Ji-Cheol
authors: JC
authors: Bae
authors: Won-Jun
authors: WJ
authors: Kim
authors: Eun-Suk
authors: ES
authors: Choi
authors: Se Eun
authors: SE
authors: Park
authors: Cheol-Young
authors: CY
authors: Park
authors: Seok Won
authors: SW
authors: Park
authors: Ki-Won
authors: KW
authors: Oh
authors: Sung-Woo
authors: SW
authors: Park
authors: Sun-Woo
authors: SW
authors: Kim
authors: Won-Young
authors: WY
authors: Lee