title: Bile salts induce resistance to polymyxin in enterohemorrhagic Escherichia coli O157:H7.
abstract: Many enteric bacteria use bile as an environmental cue to signal resistance and virulence gene expression. Microarray analysis of enterohemorrhagic Escherichia coli O157:H7 (EHEC) treated with bile salts revealed upregulation of genes for an efflux system (acrAB), a two-component signal transduction system (basRS/pmrAB), and lipid A modification (arnBCADTEF and ugd). Bile salt treatment of EHEC produced a basS- and arnT-dependent resistance to polymyxin.
authors: Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, ON M5B 2K3, Canada.
authors: Julianne V
authors: JV
authors: Kus
authors: Ahferom
authors: A
authors: Gebremedhin
authors: Vica
authors: V
authors: Dang
authors: Seav-Ly
authors: SL
authors: Tran
authors: Anca
authors: A
authors: Serbanescu
authors: Debora
authors: D
authors: Barnett Foster
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism; D001647:Bile Acids and Salts / Q000494:pharmacology*; D019453:Escherichia coli O157 / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D046228:Microarray Analysis; D011113:Polymyxins / Q000378:metabolism*; D018272:Porins / Q000235:genetics / Q000378:metabolism; D022621:Shiga Toxin / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D015854:Up-Regulation
chemical_list: D001425:Bacterial Outer Membrane Proteins; D001647:Bile Acids and Salts; D011113:Polymyxins; D018272:Porins; D022621:Shiga Toxin