title: Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: a case report.
abstract: We herein report a case of signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma. A 79-year-old female presented with a pulmonary tumor located in the right lower lobe measuring 21 mm in size. A right lower lobectomy was performed. The postoperative pathological examination revealed signet ring cell carcinoma with abundant mucin pools, and a multiplex RT-PCR analysis revealed the variant 2 inversion of the EML4-ALK gene.
authors: Department of Thoracic Oncology, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka 811-1395, Japan.
authors: Taro
authors: T
authors: Ohba
authors: Kenji
authors: K
authors: Sugio
authors: Takuro
authors: T
authors: Kometani
authors: Masafumi
authors: M
authors: Yamaguchi
authors: Motoharu
authors: M
authors: Hamatake
authors: Kaname
authors: K
authors: Nosaki
authors: Hiroaki
authors: H
authors: Takeoka
authors: Hiromoto
authors: H
authors: Kitajima
authors: Fumihiko
authors: F
authors: Hirai
authors: Takashi
authors: T
authors: Seto
authors: Kenichi
authors: K
authors: Taguchi
authors: Kenichi
authors: K
authors: Nishiyama
authors: Yoshitaka
authors: Y
authors: Shida
authors: Yukito
authors: Y
authors: Ichinose
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000097:blood; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D002637:Chest Pain; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism*; D011013:Pneumonectomy; D011859:Radiography; D011877:Radionuclide Imaging
chemical_list: D002272:Carcinoembryonic Antigen; C522504:EML4-ALK fusion protein, human; D015514:Oncogene Proteins, Fusion