title: Serum macrophage colony-stimulating factor (M-CSF) in patients with Hodgkin lymphoma.
abstract: Macrophage colony-stimulating factor (M-CSF) was recently implicated by in vitro studies as a survival and proliferation factor for Hodgkin/Reed-Sternberg cells. We evaluated pre-treatment serum M-CSF levels in 66 patients with histopathologic diagnosis of classical Hodgkin lymphoma (HL) and looked for possible correlations with baseline clinical characteristics. Significantly higher M-CSF serum concentrations were found in patients with bulky mediastinal mass, systemic symptoms, and elevated ESR but not LDH. There was no significant association between M-CSF level and sex, clinical stage, number of lymph node areas involved, and histopathological subtype of HL. We conclude that serum M-CSF levels are frequently elevated in HL patients and are significantly related to the presence of bulky mediastinal mass and systemic symptoms. These observations may indicate a pathogenetic role of M-CSF in Hodgkin lymphoma.
authors: The Maria Sklodowska-Curie Memorial Institute and Cancer Center, Warszawa, Poland.
authors: Maria
authors: M
authors: Kowalska
authors: Joanna
authors: J
authors: Tajer
authors: Magdalena
authors: M
authors: Chechlinska
authors: Malgorzata
authors: M
authors: Fuksiewicz
authors: Beata
authors: B
authors: Kotowicz
authors: Janina
authors: J
authors: Kaminska
authors: Jan
authors: J
authors: Walewski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006689:Hodgkin Disease / Q000097:blood* / Q000473:pathology*; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D016173:Macrophage Colony-Stimulating Factor