title: Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum.
abstract: Palmerolides D-G are new bioactive macrolides isolated from the Antarctic tunicate Synoicum adareanum and are related to the melanoma-selective cytotoxin palmerolide A. Most of these palmerolides are potent V-ATPase inhibitors and have sub-micromolar activity against melanoma. Though palmerolide A remains the most potent of this series of natural products against mammalian V-ATPase, recent data suggests that palmerolide D is the most potent against melanoma. A comparison of the bioactivity data obtained for these natural product palmerolides has provided insight into the substructures necessary to retain V-ATPase inhibition and cytotoxic activity.
authors: Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
authors: Jaime H
authors: JH
authors: Noguez
authors: Thushara K K
authors: TK
authors: Diyabalanage
authors: Yoshinari
authors: Y
authors: Miyata
authors: Xiao-Song
authors: XS
authors: Xie
authors: Frederick A
authors: FA
authors: Valeriote
authors: Charles D
authors: CD
authors: Amsler
authors: James B
authors: JB
authors: McClintock
authors: Bill J
authors: BJ
authors: Baker
mesh_terms: D000818:Animals; D000864:Antarctic Regions; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002417:Cattle; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008545:Melanoma / Q000188:drug therapy; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D014561:Urochordata / Q000737:chemistry*; D025262:Vacuolar Proton-Translocating ATPases / Q000037:antagonists & inhibitors
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; C522534:palmerolide A; D025262:Vacuolar Proton-Translocating ATPases