title: Hyperostosis frontalis interna (HFI) and castration: the case of the famous singer Farinelli (1705-1782).
abstract: The famous castrato singer Farinelli (1705-1782) was exhumed by our research group in July 2006 for the purpose of gaining some insight into his biological profile through a study of his skeletal remains. Farinelli was castrated before puberty to preserve the treble pitch of the boy's voice into adult life. His powerful and sweet voice became legendary. In spite of its bad preservation state, the skeleton displayed some interesting characteristics that are probably related to the effects of castration, including long limb-bones, persistence of epiphyseal lines and osteoporosis. In particular, the frontal bone was affected by severe hyperostosis frontalis interna (HFI). This condition consists in a symmetrical thickening of the inner table of the bone. The epidemiology of HFI shows that it is relatively common in postmenopausal women but very rare in men. Men affected by this pathology suffer from diseases, syndromes or treatments causing androgen deficiency. In the case of Farinelli, castration was probably responsible for the onset and development of this lesion.
authors: Laboratory of Bioarchaeology and Forensic Osteology, Department of Experimental Evolutionary Biology, Alma Mater Studiorum University of Bologna, Bologna, Italy. maria.belcastro@unibo.it
authors: Maria Giovanna
authors: MG
authors: Belcastro
authors: Antonio
authors: A
authors: Todero
authors: Gino
authors: G
authors: Fornaciari
authors: Valentina
authors: V
authors: Mariotti
mesh_terms: D002102:Cadaver; D049671:History, 18th Century; D006801:Humans; D006957:Hyperostosis Frontalis Interna / Q000266:history* / Q000473:pathology; D008297:Male; D009146:Music / Q000266:history*; D009919:Orchiectomy / Q000009:adverse effects / Q000266:history*