title: ADAMTS-13 deficiency following Hemiscorpius lepturus scorpion sting.
abstract: Hemiscorpius lepturus is a lethal scorpion with potentially cytotoxic venom. Various degrees of local and systemic toxicity have been observed after its envenomation ranging from local erythema to disseminated intravascular coagulation, renal failure and severe pulmonary hemorrhage. In this case report, we report on a seven-year-old patient who developed the hemolytic uremic syndrome (HUS) after being stung by the scorpion H. lepturus. This condition is characterized by microangiopathic hemolytic anemia, thrombocytopenia, increased serum levels of lactate dehydrogenase and uremia. We evaluated the causes of HUS and found that the levels of C3, C4, CH50 and H factors were normal, but the activity of Von Willebrand factor cleaving protease was decreased (less than 5% of the normal activity). The patient improved after administering therapy with plasma exchange.
authors: Department of Nephrology, Jundishapur University of Medical Sciences, Ahvaz, Iran. dr_ehsan_valavi@yahoo.com
authors: Ehsan
authors: E
authors: Valavi
authors: Mohammad Javad Alemzadeh
authors: MJ
authors: Ansari
authors: Sudabeh
authors: S
authors: Hoseini
mesh_terms: D051722:ADAM Proteins / Q000097:blood / Q000172:deficiency*; D000071120:ADAMTS13 Protein; D000743:Anemia, Hemolytic / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D000818:Animals; D001733:Bites and Stings / Q000150:complications*; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D065008:Scorpion Stings / Q000150:complications*; D012604:Scorpion Venoms / Q000506:poisoning*; D012605:Scorpions; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D012604:Scorpion Venoms; D014841:von Willebrand Factor; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human