title: Increasing the speed limit for hole transport in DNA.
abstract: Transport of positive charge or holes in DNA occurs via a thermally activated multi-step hopping mechanism. The fastest hopping rates reported to date are those for repeating poly(purine) sequences in which hopping occurs via a random walk mechanism with rate constants of k(hop) = 4.3 × 10(9) s(-1) for poly(dG) and 1.2 × 10(9) s(-1) for poly(dA). We report here the dynamics of charge separation in DNA conjugates possessing repeating 7-deazaadenine (dzA) sequences. These data provide an estimated value of k(hop) = 4.2 × 10(10) s(-1) for poly(dzA), an order of magnitude faster than for poly(dG).
authors: Department of Chemistry and Argonne-Northwestern Solar Energy Research (ANSER) Center, Northwestern University, Evanston, Illinois 60206-3113, USA.
authors: Arun K
authors: AK
authors: Thazhathveetil
authors: Anton
authors: A
authors: Trifonov
authors: Michael R
authors: MR
authors: Wasielewski
authors: Frederick D
authors: FD
authors: Lewis
mesh_terms: D004247:DNA / Q000737:chemistry*; D015394:Molecular Structure; D011687:Purines / Q000737:chemistry
chemical_list: D011687:Purines; D004247:DNA