title: The potential role of honey and its polyphenols in preventing heart diseases: a review.
abstract: Honey is rich in phenolic compounds, which act as natural antioxidants and are becoming increasingly popular because of their potential role in contributing to human health. A wide range of phenolic constituents is present in honey like quercetin, caffeic acid phenethyl ester (CAPE), acacetin, kaempferol, galangin which have promising effect in the treatment of cardiovascular diseases. Many epidemiological studies have shown that regular intake of phenolic compounds is associated with reduced risk of heart diseases. In coronary heart disease, the protective effects of phenolic compounds include mainly antithrombotic, anti-ischemic, anti-oxidant, and vasorelaxant. It is suggested that flavonoids decrease the risk of coronary heart disease by three major actions: improving coronary vasodilatation, decreasing the ability of platelets in the blood to clot, and preventing low-density lipoproteins (LDLs) from oxidizing. In this review paper, we discussed the preventive role of polyphenols of honey against cardiovascular diseases.
authors: Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia. mibrahim12@yahoo.com
authors: M I
authors: MI
authors: Khalil
authors: S A
authors: SA
authors: Sulaiman
mesh_terms: D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D005419:Flavonoids / Q000737:chemistry*; D006331:Heart Diseases / Q000517:prevention & control*; D006722:Honey / Q000032:analysis*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D010636:Phenols / Q000737:chemistry*; D059808:Polyphenols
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols