title: Preparation of α-alkyl-β-amino acids via β-alanine Ni(II) complex.
abstract: A new β-amino acrylic acid Ni(II) complex has been developed and used for the synthesis of α-alkyl-β-amino acids via alkylation with alkyl halides under operationally convenient conditions. The pivotal α-alkylated intermediate can be converted into the corresponding α-alkyl-β-amino acids via two steps with a wide range of substituents.
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People's Republic of China.
authors: Daizong
authors: D
authors: Lin
authors: Li
authors: L
authors: Lv
authors: Jiang
authors: J
authors: Wang
authors: Xiao
authors: X
authors: Ding
authors: Hualiang
authors: H
authors: Jiang
authors: Hong
authors: H
authors: Liu
mesh_terms: D000478:Alkylation; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005998:Glycine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D015091:beta-Alanine / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D009942:Organometallic Compounds; D015091:beta-Alanine; D009532:Nickel; D005998:Glycine