title: Psoriasis and cardiovascular risk factors: a case-control study on inpatients comparing psoriasis to dermatitis.
abstract: BACKGROUND
  Previous reports demonstrated an association between psoriasis and cardiovascular disease (CVD) risk factors. However, most of these studies were based on computerized databases of outpatient clinics, which, because of International Classification of Diseases, Ninth Revision coding issues, require validation of the diagnosis of psoriasis.
  
  
  OBJECTIVE
  We sought to study associations between psoriasis and CVD risk factors among psoriatic inpatients compared to inpatients with dermatitis.
  
  
  METHODS
  A case-control study was performed using computerized medical databases from the Department of Dermatology at Rabin Medical Center in Israel. Inpatients given the diagnosis of psoriasis were compared with inpatients given the diagnosis of forms of dermatitis for the prevalence of smoking, obesity, diabetes, hypertension, hyperlipidemia, and CVD. Logistic regression models were used for multivariate analyses.
  
  
  RESULTS
  The study included 1079 inpatients with psoriasis and 1079 age- and gender-matched inpatients with dermatitis (control patients). A multivariate logistic regression model demonstrated that psoriasis is an independent risk factor for diabetes (odds ratio [OR] 1.43; 95% confidence interval [CI] 1.17-1.75), hypertension (OR 1.31; 95% CI 1.09-1.58), obesity (OR 1.32; 95% CI 0.99-1.76), and smoking (OR 1.38; 95% CI 1.10-1.73). Development of CVD was not significantly associated with psoriasis when correcting for diabetes, obesity, and hypertension.
  
  
  CONCLUSIONS
  Our study group was composed of inpatients only, which may be biased toward more elderly patients with severe psoriasis who may have consumed systemic treatment including immunosuppressants.
  
  
  CONCLUSIONS
  Our study supports previous reports of an association between psoriasis and CVD risk factors, suggesting that the inflammatory process in psoriasis, but not in dermatitis, may have a systemic impact resulting in development of CVD risk factors.
authors: Rabin Medical Center, Petah Tikva, Sackler School of Medicine, Tel Aviv University, Israel.
authors: Jonathan
authors: J
authors: Shapiro
authors: Arnon David
authors: AD
authors: Cohen
authors: Dahlia
authors: D
authors: Weitzman
authors: Roy
authors: R
authors: Tal
authors: Michael
authors: M
authors: David
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000209:etiology*; D016022:Case-Control Studies; D003872:Dermatitis / Q000150:complications*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology; D050171:Dyslipidemias / Q000209:etiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007297:Inpatients; D007557:Israel / Q000453:epidemiology; D008297:Male; D016347:Medical Records Systems, Computerized; D008875:Middle Aged; D009765:Obesity / Q000209:etiology; D011565:Psoriasis / Q000150:complications*; D012042:Registries; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects