title: A long-term competent chimeric immune system in a dizygotic dichorionic twin.
abstract: We present here a rare case that involved the long-term coexistence of 2 mature, functional, and equilibrated immune systems in a single child after fetofetal transfusion between dizygotic twins. A dichorionic diamniotic pregnancy complicated by twin anemia-polycythemia sequence resulted in the demise of 1 twin. The detection of abnormal vessels on the dichorionic plate strongly suggested the existence of functional vascular anastomoses leading to blood chimerism in the survivor. Genetic, phenotypic, and immunologic analyses at 2 years revealed chimeric lymphoid and myeloid cells in the surviving twin, although no tissue mosaicism was detected, which indicates that early transfusion led to mutual immune tolerance.
authors: NSERM, U676, AVENIR RO5230HS Team, Paris, France.
authors: Valerie
authors: V
authors: Biran
authors: Marie
authors: M
authors: Bornes
authors: Azzedine
authors: A
authors: Aboura
authors: Sonia
authors: S
authors: Masmoudi
authors: Séverine
authors: S
authors: Drunat
authors: Clarisse
authors: C
authors: Baumann
authors: Sara
authors: S
authors: Osimani
authors: Jean-Hugues
authors: JH
authors: Dalle
authors: Ghislaine
authors: G
authors: Sterkers
authors: Alain
authors: A
authors: Verloes
authors: Caroline
authors: C
authors: Farnoux
authors: Laure
authors: L
authors: Maury
authors: Thomas
authors: T
authors: Schmitz
authors: Suonavy
authors: S
authors: Khung
authors: Olivier
authors: O
authors: Baud
mesh_terms: D046528:Chimerism; D002823:Chorion / Q000276:immunology*; D005260:Female; D005313:Fetal Death; D005330:Fetofetal Transfusion / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000196:embryology* / Q000276:immunology; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D013997:Time Factors; D014429:Twins, Dizygotic / Q000276:immunology*; D055815:Young Adult