title: Drosophila Sex lethal gene initiates female development in germline progenitors.
abstract: Sex determination in the Drosophila germ line is regulated by both the sex of the surrounding soma and cell-autonomous cues. How primordial germ cells (PGCs) initiate sexual development via cell-autonomous mechanisms is unclear. Here, we demonstrate that, in Drosophila, the Sex lethal (Sxl) gene acts autonomously in PGCs to induce female development. Sxl is transiently expressed in PGCs during their migration to the gonads; this expression, which was detected only in XX PGCs, is necessary for PGCs to assume a female fate. Ectopic expression of Sxl in XY PGCs was sufficient to induce them to enter oogenesis and produce functional eggs when transplanted into an XX host. Our data provide powerful evidence that Sxl initiates female germline fate during sexual development.
authors: Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama, Myodaiji, Okazaki 444-8787, Japan.
authors: Kazuya
authors: K
authors: Hashiyama
authors: Yoshiki
authors: Y
authors: Hayashi
authors: Satoru
authors: S
authors: Kobayashi
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D002465:Cell Movement; D004330:Drosophila / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics* / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000502:physiology; D047108:Embryonic Development; D005260:Female; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D005854:Germ Cells / Q000166:cytology / Q000502:physiology* / Q000637:transplantation; D006066:Gonads / Q000166:cytology* / Q000196:embryology; D008297:Male; D009866:Oogenesis; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D012730:Sex Chromosomes; D019849:Sex Determination Processes
chemical_list: D029721:Drosophila Proteins; D016601:RNA-Binding Proteins; C067777:Sxl protein, Drosophila