title: [Analyses of restricted diffusion of water molecules using trabecular bone phantom].
abstract: We have reported that the apparent diffusion coefficient (ADC) was correlated with bone mineral density, but the relation between the restricted diffusion of the water molecules and the trabecular bone structure was unclear. The purpose of our study is to clarify this relationship using two component analyses with an original phantom. With an increase in the interspace area of the simulated trabecular bone, the ADC of the fast component was increased, and the fraction of the fast component was also increased. On the other hand, with an increase in the interspace area of the simulated trabecular bone, the ADC of the slow component was decreased, and the fraction of the slow component was increased. Moreover, the ADC and fraction of the dry vertebral bone agreed with those of the simulated trabecular bone. This result means that our phantoms can reproduce the actual trabecular bone structure, which induces the restricted diffusion. The diffusion of the water molecules was separated into fast and slow components because of the restricted diffusion of the trabecular bone structure. Our original phantom enables analyzing restricted diffusion, and this analytical method obtains more detailed information on trabecular bone structure.
authors: Division of Health Sciences, Graduate School of Medical Science, Kanazawa University.
authors: Takashi
authors: T
authors: Minami
authors: Tosiaki
authors: T
authors: Miyati
authors: Yu
authors: Y
authors: Ueda
authors: Hirohito
authors: H
authors: Kan
authors: Akihiro
authors: A
authors: Kitanaka
authors: Harumasa
authors: H
authors: Kasai
authors: Nobuyuki
authors: N
authors: Arai
authors: Masaki
authors: M
authors: Hara
authors: Yuta
authors: Y
authors: Shibamoto
authors: Shigeyoshi
authors: S
authors: Yokoti
mesh_terms: D015519:Bone Density; D004058:Diffusion; D006801:Humans; D008279:Magnetic Resonance Imaging; D019047:Phantoms, Imaging; D014867:Water
chemical_list: D014867:Water