title: Stereoselective palladium-catalyzed α-arylation of 3-aryl-1-indanones: an asymmetric synthesis of (+)-pauciflorol F.
abstract: Highly stereoselective, palladium-catalyzed α-arylation reactions of 3-aryl-1-indanones with aryl bromides are described. The use of sodium tert-butoxide as a base in this process is required to elevate the efficiencies and stereoselectivities of these reactions. The new methodology was successfully applied to a highly efficient route for the asymmetric synthesis of (+)-pauciflorol F.
authors: Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, 100 Jang-dong, Daejeon 305-600, Korea.
authors: Bong Hyang
authors: BH
authors: Lee
authors: Young Lok
authors: YL
authors: Choi
authors: Seunghoon
authors: S
authors: Shin
authors: Jung-Nyoung
authors: JN
authors: Heo
mesh_terms: D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D007189:Indans / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006842:Hydrocarbons, Brominated; D007189:Indans; D013267:Stilbenes; C487911:pauciflorol F; D010165:Palladium