title: Long-term clinical outcomes of overlapping heterogeneous drug-eluting stents compared with homogeneous drug-eluting stents.
abstract: OBJECTIVE
  To evaluate long-term clinical outcomes of overlapping heterogeneous drug-eluting stents (DES) compared with homogeneous DES.
  
  
  METHODS
  The catholic medical centre coronary intervention database is a multicentre database of percutaneous coronary intervention with DES. This database contains data on consecutive patients from eight coronary intervention centres in Korea.
  
  
  METHODS
  Overlapping homogeneous DES were used in 940 patients and overlapping heterogeneous DES in 140 patients between January 2005 and June 2010.
  
  
  METHODS
  The study enrolled patients with one-vessel disease treated with two overlapping DES in one lesion.
  
  
  METHODS
  The study end point was the occurrence of major adverse cardiac events (MACE), defined as cardiac death, myocardial infarction (MI) or target lesion revascularisation (TRL).
  
  
  RESULTS
  The two patient groups had similar baseline clinical and angiographic characteristics. MACE, cardiac death, MI and TRL rates, were not significantly different between the homogeneous and heterogeneous DES groups (9.9% vs 11.4%, p=0.574; 2.7% vs 3.6%, p=0.578; 1.5% vs 1.4%, p=1.000; 5.7% vs 6.4%, p=0.747, respectively). In addition, it was found that overlap with second-generation DES may be safe and effective, and the sirolimus-eluting stent (SES)+SES group had higher rate of MACE-free survival than the paclitaxel-eluting stent (PES)+PES group (p=0.014).
  
  
  CONCLUSIONS
  Overlapping heterogeneous DES and overlapping homogeneous DES had similar long-term safety and efficacy outcomes.
authors: St. Paul's Hospital, Jeonnong-Dong, Dongdaemoon-Gu, Seoul 130-709, Republic of Korea.
authors: Sung-Ho
authors: SH
authors: Her
authors: Ki Dong
authors: KD
authors: Yoo
authors: Chul-Soo
authors: CS
authors: Park
authors: Dong-Bin
authors: DB
authors: Kim
authors: Jong-Min
authors: JM
authors: Lee
authors: Pum Joon
authors: PJ
authors: Kim
authors: Hee-Yeol
authors: HY
authors: Kim
authors: Kiyuk
authors: K
authors: Chang
authors: Doo Soo
authors: DS
authors: Jeon
authors: Wook Sung
authors: WS
authors: Chung
authors: Ki-Bae
authors: KB
authors: Seung
authors: Jae-Hyung
authors: JH
authors: Kim
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000628:therapy*; D023903:Coronary Restenosis; D016208:Databases, Factual; D054855:Drug-Eluting Stents; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016896:Treatment Outcome