title: Second generation of fucose-based DC-SIGN ligands: affinity improvement and specificity versus Langerin.
abstract: DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (Le(X)). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection.
authors: Universita' degli Studi di Milano, Dipartimento di Chimica Organica e Industriale and CISI, Milano, Italy.
authors: Manuel
authors: M
authors: Andreini
authors: Daniela
authors: D
authors: Doknic
authors: Ieva
authors: I
authors: Sutkeviciute
authors: José J
authors: JJ
authors: Reina
authors: Janxin
authors: J
authors: Duan
authors: Eric
authors: E
authors: Chabrol
authors: Michel
authors: M
authors: Thepaut
authors: Elisabetta
authors: E
authors: Moroni
authors: Fabio
authors: F
authors: Doro
authors: Laura
authors: L
authors: Belvisi
authors: Joerg
authors: J
authors: Weiser
authors: Javier
authors: J
authors: Rojo
authors: Franck
authors: F
authors: Fieschi
authors: Anna
authors: A
authors: Bernardi
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D015703:Antigens, CD / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D005643:Fucose / Q000737:chemistry* / Q000494:pharmacology*; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D037181:Lectins, C-Type / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D037241:Mannose-Binding Lectins / Q000378:metabolism; D008958:Models, Molecular; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D019380:Anti-HIV Agents; D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D005643:Fucose; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C121916:CD207 protein, human