title: The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases.
abstract: The interleukin-17 (IL-17) cytokines, IL-17A to IL-17F, are emerging as critical players in host defence responses and inflammatory diseases. Substantial data support the role of these proteins in innate and adaptive immunity. Of these family members, IL-17A, IL-17F and IL-17E have been the best studied. Both IL-17A and IL-17F contribute to the host response to extracellular bacteria and fungi, and IL-17E has been shown to play a role in parasitic infections. In addition, numerous pre-clinical and clinical studies link these proteins to the pathogenesis of inflammatory diseases, and a number of therapeutic programmes targeting these family members are in clinical development. This review will highlight the cellular sources, receptors/target cells, and role in inflammation of these and the less-characterized family members, IL-17B, IL-17C and IL-17D.
authors: Department of Immunology, Genentech Inc., South San Francisco, CA, USA. rajitap@gene.com
authors: Rajita
authors: R
authors: Pappu
authors: Vladimir
authors: V
authors: Ramirez-Carrozzi
authors: Arivazhagan
authors: A
authors: Sambandam
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007249:Inflammation / Q000209:etiology / Q000378:metabolism*; D020381:Interleukin-17 / Q000502:physiology*; D053722:Receptors, Interleukin-17 / Q000502:physiology
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17