title: Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft parts.
abstract: Pleomorphic hyalinizing angiectatic tumor of soft parts is a recently recognized, low-grade mesenchymal neoplasm of uncertain lineage. It is characterized by clusters of ectatic, fibrin-lined, thin-walled vessels surrounded by pleomorphic but mitotically inert spindled cells with frequent intranuclear inclusions and a variable inflammatory component. Here, we report a case of recurrent pleomorphic hyalinizing angiectatic tumor in a 37-year-old white woman. Touch imprint cytologic analysis revealed oval and spindled cells with fine chromatin, occasional prominent intranuclear inclusions, and intracytoplasmic pigment. The histologic features of the cells constituting the bulk of tumor were those characteristic of a putative precursor lesion ("early pleomorphic hyalinizing angiectatic tumor") as well as another recently described entity known as hemosiderotic fibrohistiocytic lipomatous lesion. Cytogenetic analysis revealed 2 unbalanced translocations involving chromosomes 1 and 3 and chromosomes 1 and 10, with a karyotype of 45,XX,der(1)t(1;3)(p31;q12),-3,der(10)t(1;10)(p31;q25)[11]/46,XX[4], thus suggesting that this disease is neoplastic. The controversies in classification of these lesions are also discussed.
authors: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249-7331, USA. swei@uab.edu
authors: Shi
authors: S
authors: Wei
authors: Zenggang
authors: Z
authors: Pan
authors: Gene P
authors: GP
authors: Siegal
authors: Thomas S
authors: TS
authors: Winokur
authors: Andrew J
authors: AJ
authors: Carroll
authors: Darshana
authors: D
authors: Jhala
mesh_terms: D059786:Abnormal Karyotype; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001808:Blood Vessels / Q000473:pathology; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D002893:Chromosomes, Human, Pair 3; D003131:Combined Modality Therapy; D020732:Cytogenetic Analysis; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004108:Dilatation, Pathologic / Q000473:pathology; D005260:Female; D005528:Foot; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D008637:Mesenchymoma / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D009364:Neoplasm Recurrence, Local; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor