title: Immunoregulatory molecule B7-H1 (CD274) contributes to skin carcinogenesis.
abstract: B7-H1 (CD274), a member of the B7 family of coinhibitory molecules, is often induced in human tumors and its expression is closely correlated with a poor prognosis or higher malignancy grade. Tumor-associated B7-H1 is implicated in mechanisms of immune escape. Under inflammatory conditions, B7-H1 is also inducible in normal epithelial cells, but little is known about its involvement in the conversion of normal cells to tumor cells. We recently found that skin-specific expression of B7-H1 accelerates chemically induced carcinogenesis of squamous cell carcinoma (SCC), despite impaired skin inflammatory responses, in B7-H1 transgenic (B7-H1tg) mice. B7-H1tg-derived keratinocytes (KC) and SCCs exhibited a marked reduction of E-cadherin, and B7-H1tg-originated SCCs showed elevated expression of the transcription factors Slug and Twist, suggesting that B7-H1 overexpression in KCs promotes the epithelial-mesenchymal transition and accelerates carcinogenesis. This review discusses the diverse functions of B7-H1 in carcinogenesis and cancer progression, and considers future directions for developing cancer therapy targeting B7-H1.
authors: Departments of Molecular Immunology and Oral and Maxillo-facial Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
authors: Yujia
authors: Y
authors: Cao
authors: Lu
authors: L
authors: Zhang
authors: Pacharee
authors: P
authors: Ritprajak
authors: Fumihiko
authors: F
authors: Tsushima
authors: Pornpan
authors: P
authors: Youngnak-Piboonratanakit
authors: Yosuke
authors: Y
authors: Kamimura
authors: Masaaki
authors: M
authors: Hashiguchi
authors: Miyuki
authors: M
authors: Azuma
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D018122:B7-1 Antigen / Q000276:immunology*; D060890:B7-H1 Antigen; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D010455:Peptides / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D018122:B7-1 Antigen; D060890:B7-H1 Antigen; C423236:CD274 protein, human; C498919:Cd274 protein, mouse; D008562:Membrane Glycoproteins; D010455:Peptides