title: An experimental approach to studying the effectiveness and safety of meglumine antimoniate formulations.
abstract: Among the problems associated to leishmaniasis, the two most outstanding ones are the lack of a vaccine and the adverse effects caused by drugs use for its control. Meglumine antimoniate compounds are the first-line drugs in the treatment for cutaneous leishmaniasis (the most prevalent form of the disease in Colombia); nevertheless, they are far from being ideal drugs due to their toxicity (not to mention the emergence of drug-resistant parasites), all of which has prompted current search for new strategies to improve their safety. This work assesses the effectiveness and safety (toxicity including new aspects related with immunotoxicity not reported previously) of two different meglumine antimoniate formulations using an in vitro and in vivo murine model. The results evidence that although both injectable formulations induce an equally efficient (clearance of intracellular parasites), both give rise to adverse effects, including a preferential immunomodulation on Balb/c mice and in a lesser proportion on ICR mice. These results are comparable to human trials reporting variable reactions when following the same treatment regimen. The model presented herein is proposed as a tool for evaluating the effectiveness and safety of meglumine antimoniate-based antileishmanial formulations.
authors: Immunotoxicology Research Group, Pharmacy Department, Science Faculty, Universidad Nacional de Colombia, Oficina 206, Ciudad Universitaria, Carrera 30 No. 45-03, Edificio 450, Bogotá, D.C., Colombia. lgdelgadom@unal.edu.co
authors: G
authors: G
authors: Delgado
authors: Y
authors: Y
authors: Sánchez
authors: D
authors: D
authors: Plaza
authors: A
authors: A
authors: Mariño
authors: D
authors: D
authors: Granados
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D004195:Disease Models, Animal; D005260:Female; D056747:Immunomodulation / Q000187:drug effects; D066298:In Vitro Techniques; D007273:Injections, Intramuscular; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D008536:Meglumine / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D000077485:Meglumine Antimoniate; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D013045:Species Specificity; D018675:Toxicity Tests
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate