title: Automated solid phase synthesis of teichoic acids.
abstract: This communication describes the first automated solid phase synthesis of teichoic acids (TAs) and the preparation by this method of a number of well-defined TA structures, which were probed for their antigenicity. An opsonophagocytic killing assay revealed a clear TA-length-activity relationship and indicated a promising candidate for future vaccine development.
authors: Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
authors: Wouter F J
authors: WF
authors: Hogendorf
authors: Nico
authors: N
authors: Meeuwenoord
authors: Herman S
authors: HS
authors: Overkleeft
authors: Dmitri V
authors: DV
authors: Filippov
authors: Diana
authors: D
authors: Laverde
authors: Andrea
authors: A
authors: Kropec
authors: Johannes
authors: J
authors: Huebner
authors: Gijsbert A
authors: GA
authors: Van der Marel
authors: Jeroen D C
authors: JD
authors: Codée
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D013293:Enterococcus faecalis / Q000187:drug effects; D005947:Glucose / Q000737:chemistry; D005990:Glycerol / Q000737:chemistry; D011817:Rabbits; D013682:Teichoic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000276:immunology; D014614:Vaccines, Synthetic / Q000737:chemistry / Q000276:immunology
chemical_list: D000906:Antibodies; D013682:Teichoic Acids; D014614:Vaccines, Synthetic; D005947:Glucose; D005990:Glycerol