title: High-fat diets affect energy and bone metabolism in growing rats.
abstract: BACKGROUND
  High-fat diets are usually associated with greater weight (W) gain and body fat (BF). However, it is still unclear whether the type and amount of fat consumed influence BF. Additionally, dietary fat intake may also have consequences on skeletal health.
  
  
  OBJECTIVE
  To evaluate in healthy growing rats the effects of high-fat diets and type of dietary fat intake (saturated or vegetable oils) on energy and bone metabolism.
  
  
  METHODS
  At weaning, male Wistar rats (n = 50) were fed either a control diet (C; fat = 7% w/w) or a high-fat diet (20% w/w) containing either: soybean oil, corn oil (CO), linseed oil (LO), or beef tallow (BT) for 8 weeks. Zoometric parameters, BF, food intake and digestibility, and total and bone alkaline phosphatase (b-AP) were assessed. Total skeleton bone mineral density (BMD) and content (BMC), BMC/W, spine BMD, and bone volume (static-histomorphometry) were measured.
  
  
  RESULTS
  Animals fed BT diet achieved lower W versus C. Rats fed high-fat vegetable oil diets showed similar effects on the zoometric parameters but differed in BF. BT showed the lowest lipid digestibility and BMC. In contrast, high vegetable oil diets produced no significant differences in BMC, BMC/W, BMD, spine BMD, and bone volume. Marked differences were observed for LO and BT groups in b-AP and CO and BT groups in bone volume.
  
  
  CONCLUSIONS
  BT diet rich in saturated fatty acids had decreased digestibility and adversely affected energy and bone metabolisms, in growing healthy male rats. There were no changes in zoometric and bone parameters among rats fed high vegetable oil diets.
authors: Department of Biochemistry, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
authors: Elisa V
authors: EV
authors: Macri
authors: Macarena M
authors: MM
authors: Gonzales Chaves
authors: Patricia N
authors: PN
authors: Rodriguez
authors: Patricia
authors: P
authors: Mandalunis
authors: Susana
authors: S
authors: Zeni
authors: Fima
authors: F
authors: Lifshitz
authors: Silvia M
authors: SM
authors: Friedman
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001846:Bone Development; D001842:Bone and Bones / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D002417:Cattle; D003314:Corn Oil / Q000009:adverse effects / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects*; D004063:Digestion; D004734:Energy Metabolism; D005223:Fats / Q000009:adverse effects* / Q000378:metabolism; D007527:Isoenzymes / Q000097:blood; D008043:Linseed Oil / Q000009:adverse effects / Q000378:metabolism; D008297:Male; D008903:Minerals / Q000032:analysis; D010938:Plant Oils / Q000009:adverse effects* / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000009:adverse effects / Q000378:metabolism; D014886:Weaning
chemical_list: D005223:Fats; D007527:Isoenzymes; D008903:Minerals; D010938:Plant Oils; D013024:Soybean Oil; D008043:Linseed Oil; D003314:Corn Oil; C013698:tallow; D000469:Alkaline Phosphatase