title: Sustained release of doxorubicin from zeolite-magnetite nanocomposites prepared by mechanical activation.
abstract: Nanocomposites consisting of magnetite and FAU zeolite with a high surface area and adsorption capacity have been prepared by mechanical activation using high-energy milling at room temperature. FTIR results, as well as HRTEM, EFTEM, and XPS measurements, show that the resulting magnetic nanoparticles are covered by a thin aluminosilicate coating. A saturation magnetization as high as 16 emu g(-1) and 94.2 Oe of coercivity were observed for the obtained composites. The main advantages of this synthesis procedure are (i) simplicity of the preparation procedure, (ii) prevention of agglomeration of the magnetite nanoparticles to a large extent, and (iii) absence of free magnetite outside the zeolitic matrix. In addition, in vitro experiments revealed that the nanoparticles prepared were able to store and release substantial amounts of doxorubicin. In view of these advantages, these magnetic nanoparticles can be considered as potential candidates for drug-delivery applications.
authors: Nanoscience Institute of Aragon (INA), Pedro Cerbuna 12, University of Zaragoza, 50009 Zaragoza, Spain.
authors: Manuel
authors: M
authors: Arruebo
authors: Rodrigo
authors: R
authors: Fernández-Pacheco
authors: Silvia
authors: S
authors: Irusta
authors: Jordi
authors: J
authors: Arbiol
authors: M Ricardo
authors: MR
authors: Ibarra
authors: Jesús
authors: J
authors: Santamaría