title: A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese.
abstract: Lung cancer is the leading cause of cancer-related deaths worldwide. To identify genetic factors that modify the risk of lung cancer in individuals of Chinese ancestry, we performed a genome-wide association scan in 5,408 subjects (2,331 individuals with lung cancer (cases) and 3,077 controls) followed by a two-stage validation among 12,722 subjects (6,313 cases and 6,409 controls). The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively). Two of these loci (13q12.12 and 22q12.2) were newly identified in the Chinese population. These results suggest that genetic variants in 3q28, 5p15.33, 13q12.12 and 22q12.2 may contribute to the susceptibility of lung cancer in Han Chinese.
authors: Department of Epidemiology and Biostatistics, Ministry of Education (MOE) Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.
authors: Zhibin
authors: Z
authors: Hu
authors: Chen
authors: C
authors: Wu
authors: Yongyong
authors: Y
authors: Shi
authors: Huan
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authors: Guo
authors: Xueying
authors: X
authors: Zhao
authors: Zhihua
authors: Z
authors: Yin
authors: Lei
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authors: Yang
authors: Juncheng
authors: J
authors: Dai
authors: Lingmin
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authors: Hu
authors: Wen
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authors: Tan
authors: Zhiqiang
authors: Z
authors: Li
authors: Qifei
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authors: Deng
authors: Jiucun
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authors: Wang
authors: Wei
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authors: Wu
authors: Guangfu
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authors: Jin
authors: Yue
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authors: Jiang
authors: Dianke
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authors: Yu
authors: Guoquan
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authors: Zhou
authors: Hongyan
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authors: Chen
authors: Peng
authors: P
authors: Guan
authors: Yijiang
authors: Y
authors: Chen
authors: Yongqian
authors: Y
authors: Shu
authors: Lin
authors: L
authors: Xu
authors: Xiangyang
authors: X
authors: Liu
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authors: Liu
authors: Ping
authors: P
authors: Xu
authors: Baohui
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authors: Han
authors: Chunxue
authors: C
authors: Bai
authors: Yuxia
authors: Y
authors: Zhao
authors: Haibo
authors: H
authors: Zhang
authors: Ying
authors: Y
authors: Yan
authors: Hongxia
authors: H
authors: Ma
authors: Jiaping
authors: J
authors: Chen
authors: Mingjie
authors: M
authors: Chu
authors: Feng
authors: F
authors: Lu
authors: Zhengdong
authors: Z
authors: Zhang
authors: Feng
authors: F
authors: Chen
authors: Xinru
authors: X
authors: Wang
authors: Li
authors: L
authors: Jin
authors: Jiachun
authors: J
authors: Lu
authors: Baosen
authors: B
authors: Zhou
authors: Daru
authors: D
authors: Lu
authors: Tangchun
authors: T
authors: Wu
authors: Dongxin
authors: D
authors: Lin
authors: Hongbing
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authors: Shen
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D016022:Case-Control Studies; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D056426:Genetic Loci; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055752:Small Cell Lung Carcinoma / Q000235:genetics