title: Expression of the SNAT2 amino acid transporter during the development of rat cerebral cortex.
abstract: The sodium-coupled neutral amino acid transporter 2 (SNAT2) is a protein that is expressed ubiquitously in mammalian tissues and that displays Na(+), voltage and pH dependent activity. This transporter mediates the passage of small zwitterionic amino acids across the cell membrane and regulates the cell homeostasis and its volume. We have examined the expression of SNAT2 mRNA and protein during the development of the rat cerebral cortex, from gestation through the postnatal stages to adulthood. Our data reveal that SNAT2 mRNA and protein expression is higher during embryogenesis, while it subsequently diminishes during postnatal development. Moreover, during embryonic period SNAT2 colocalizes with the radial glial cells marker GLAST, while in postnatal period it is mainly detected in neuronal dendrites. These findings suggest a relevant role for amino acid transport through SNAT2 in the developing embryonic brain.
authors: Universidad Autónoma de Querétaro, Centro Universitario, México. angelina@uaq.mx
authors: Angelina
authors: A
authors: Rodríguez
authors: Rodríguez
authors: R
authors: Angelina
authors: Laura C
authors: LC
authors: Berumen
authors: Zafra
authors: Z
authors: Francisco
authors: Cecilio
authors: C
authors: Giménez
authors: Giménez
authors: G
authors: Cecilio
authors: María Guadalupe
authors: MG
authors: García-Alcocer
authors: García-Alcocer María
authors: GA
authors: Guadalupe
mesh_terms: D026924:Amino Acid Transport System A / Q000378:metabolism; D026905:Amino Acid Transport Systems / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism*; D027341:Excitatory Amino Acid Transporter 1 / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000378:metabolism
chemical_list: D026924:Amino Acid Transport System A; D026905:Amino Acid Transport Systems; D027341:Excitatory Amino Acid Transporter 1; D012333:RNA, Messenger; C493392:Slc1a3 protein, rat; C486716:Slc38a1 protein, rat; C412568:Slc38a2 protein, rat; D012964:Sodium