title: Chiral discrimination asserted by enantiomers of Ni (II), Cu (II) and Zn (II) Schiff base complexes in DNA binding, antioxidant and antibacterial activities.
abstract: Chiral Schiff base ligands (S)-H(2)L and (R)-H(2)L and their complexes (S-Ni-L, R-Ni-L, S-Cu-L, R-Cu-L, S-Zn-L and R-Zn-L) were synthesized, characterized and examined for their DNA binding, antioxidant and antibacterial activities. The complexes showed higher binding affinity to calf thymus DNA with binding constant ranging from 2.0×10(5) to 4.5×10(6) M(-1). All the complexes also exhibited remarkable superoxide (56-99%) and hydroxyl scavenging (45-89%) activities as well as antibacterial activities against gram (+) and gram (-) bacteria. However, none of the complexes showed antifungal activity. Conclusively, S enantiomers of the complexes were found to be relatively more efficient for DNA interaction, antioxidant and antibacterial activities than their R enantiomers. This study reveals the possible utilization of chiral Schiff base complexes for pharmaceutical applications.
authors: Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute, Council of Scientific & Industrial Research, G. B. Marg, Bhavnagar-364 021, Gujarat, India. khan251293@yahoo.in
authors: Noor-ul Hasan
authors: NU
authors: Khan
authors: Nirali
authors: N
authors: Pandya
authors: K Jeya
authors: KJ
authors: Prathap
authors: Rukhsana Ilays
authors: RI
authors: Kureshy
authors: Sayed Hasan Razi
authors: SH
authors: Abdi
authors: Sandhya
authors: S
authors: Mishra
authors: Hari Chandra
authors: HC
authors: Bajaj
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002417:Cattle; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D056831:Coordination Complexes; D012545:Schiff Bases; D003300:Copper; D009532:Nickel; D004247:DNA; D015032:Zinc