title: Association between ITGA2 C807T polymorphism and gastric cancer risk.
abstract: OBJECTIVE
  To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk.
  
  
  METHODS
  A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay.
  
  
  RESULTS
  The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P = 0.019). Compared with individuals with the wild genotype CC, subjects with the variant genotypes (CT + TT) had a significantly higher risk of gastric cancer (adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007). In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged > 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients.
  
  
  CONCLUSIONS
  The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.
authors: Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors: Jie
authors: J
authors: Chen
authors: Nan-Nan
authors: NN
authors: Liu
authors: Jia-Qi
authors: JQ
authors: Li
authors: Li
authors: L
authors: Yang
authors: Ying
authors: Y
authors: Zeng
authors: Xiao-Mei
authors: XM
authors: Zhao
authors: Lin-Lin
authors: LL
authors: Xu
authors: Xuan
authors: X
authors: Luo
authors: Bin
authors: B
authors: Wang
authors: Xue-Rong
authors: XR
authors: Wang
mesh_terms: D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D039421:Integrin alpha2