title: Antimicrobial activities of essential oil and methanol extract of Coriaria nepalensis.
abstract: Plant extracts and products have been used for centuries in traditional medicine; for most of them, in addition to the scant scientific credibility, the chemical composition and spectrum of activity are yet to be explored. To put forward this effort and to identify novel antimicrobial agents, the inhibitory activities of methanolic extract and essential oil from Coriaria nepalensis against various microorganisms including pathogenic yeast, and Gram-positive and negative bacteria were evaluated. Chemical compositions of C. nepalensis methanolic extract and essential oil were analysed by gas chromatography-mass spectrometry. In vitro susceptibility tests against all the tested isolates were performed in terms of minimum inhibitory concentration (MIC), and well diffusion assay using standard protocols. All microorganisms tested were profoundly found susceptible to both the C. nepalensis extract and oil with MIC values of 1.3-2.1 mg mL⁻¹ (Gram-positive bacteria), 1.4-2.2 mg mL⁻¹ (Gram-negative bacteria) and 0.9-1.6 mg mL⁻¹ (yeasts). The extent of inhibition was shown more by methanolic extract than by essential oil. This study is the first to report the antimicrobial activity of extracts obtained from the C. nepalensis. It can be concluded that the observed antimicrobial characteristics of C. nepalensis indicate that it might be a promising antimicrobial agent.
authors: Department of Botany and Microbiology, HNB Garhwal University, Srinagar, Uttarakhand, India. pankaj.dhiman1313@gmail.com
authors: Pankaj
authors: P
authors: Kumar
authors: R P
authors: RP
authors: Bhatt
authors: Lokendra
authors: L
authors: Singh
authors: O P
authors: OP
authors: Sati
authors: Amber
authors: A
authors: Khan
authors: Aijaz
authors: A
authors: Ahmad
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D009822:Oils, Volatile; D010936:Plant Extracts; D000432:Methanol