title: Molecular tumor clocks to study the evolution of drug resistance.
abstract: It is likely that drug resistance evolves after transformation. Exactly how these resistant cells arise is uncertain. This review outlines how the evolution of individual human cancers may be inferred by comparing genomic variation from different parts of the same tumor. The past of a tumor may help predict its responses to chemotherapy.
authors: Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, NOR 2424, Los Angeles, California 90033, United States. dshibata@usc.edu
authors: Darryl
authors: D
authors: Shibata
mesh_terms: D002471:Cell Transformation, Neoplastic; D019008:Drug Resistance, Neoplasm; D019143:Evolution, Molecular; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics