title: Gastric adenocarcinoma in children and adolescents.
abstract: Gastric adenocarcinoma (GAC) is an extremely rare cancer in children with very limited information on the clinical presentation and outcome. We report five pediatric patients with GAC-treated between 1990 and 2008 at our institution. Median age at diagnosis was 17 years (range: 8-17). Our case series suggests that pediatric GAC patients present with diffuse metastatic disease (four patients) and with patterns of spread similar to adult GAC. Initial chemotherapy was mainly platinum-based. Median time to progression was 4 months. The only long-term survivor was a patient with localized disease who had complete surgical removal of primary tumor.
authors: The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. vsubbiah@mdanderson.org
authors: Vivek
authors: V
authors: Subbiah
authors: Gauri
authors: G
authors: Varadhachary
authors: Cynthia E
authors: CE
authors: Herzog
authors: Winston W
authors: WW
authors: Huh
mesh_terms: D000230:Adenocarcinoma; D000293:Adolescent; D000951:Antigens, Neoplasm / Q000032:analysis; D002648:Child; D005190:Family; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009362:Neoplasm Metastasis; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000951:Antigens, Neoplasm