title: Systems biology in a commercial quality study of the Japanese Angelica radix: toward an understanding of traditional medicinal plants.
abstract: The commercial quality of Japanese Angelica radices -- Angelica acutiloba Kitagawa (Yamato-toki) and A. acutiloba Kitagawa var. sugiyama Hikino (Hokkai-toki) -- used in Kampo traditional herbal medicines, was studied by use of omics technologies. Complementary and alternative medical providers have observed in their clinical experience that differences in radix commercial quality reflect the differences in pharmacological responses; however, there has been little scientific examination of this phenomenon. The approach of omics, including metabolomics, transcriptomics, genomics, and informatics revealed a distinction between the radix-quality grades based on their metabolites, gene expression in human subjects, and plant genome sequences. Systems biology, constructing a network of omics data used to analyze this complex system, is expected to be a powerful tool for enhancing the study of radix quality and furthering a comprehensive understanding of all medicinal plants.
authors: Core Laboratory, Nara Prefectural Small and Medium-Sized Enterprises Support Corporation, 88 Shijo, Kashihara, Nara 634-0813, Japan. akira-katoh@bs.naist.jp
authors: Akira
authors: A
authors: Katoh
authors: Shinzo
authors: S
authors: Fukuda
authors: Eiichiro
authors: E
authors: Fukusaki
authors: Takashi
authors: T
authors: Hashimoto
authors: Tomoyuki
authors: T
authors: Hayasaki
authors: Shigehiko
authors: S
authors: Kanaya
authors: Hajime
authors: H
authors: Komura
authors: Kyosuke
authors: K
authors: Nomoto
authors: Masayuki
authors: M
authors: Shojo
authors: Kanokwan Jumtee
authors: KJ
authors: Takeno
mesh_terms: D029969:Angelica / Q000235:genetics; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000592:standards*; D023281:Genomics; D006801:Humans; D048088:Informatics; D020835:Medicine, Kampo; D055432:Metabolomics; D018517:Plant Roots; D010946:Plants, Medicinal; D012107:Research Design; D049490:Systems Biology; D059467:Transcriptome
chemical_list: D004365:Drugs, Chinese Herbal