title: 1α,25-Dihydroxyvitamin D₃ inhibits neutrophil recruitment in hamster model of acute lung injury.
abstract: The chemokine interleukin-8 (IL-8) is involved in the pathogenesis of acute lung injury (ALI). Although several studies have reported that 1α,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)) suppresses IL-8 production in vitro and in vivo, 1α,25(OH)(2)D(3) has not been demonstrated to be effective in an animal model of ALI. Here, we determined its effects of 1α,25(OH)(2)D(3) in a hamster model where ALI was induced by lipopolysaccharide (LPS) inhalation. 1α,25(OH)(2)D(3) inhibited neutrophil recruitment in the lung by approximately 40% without increasing plasma calcium concentration, while it did not inhibit monocyte recruitment. Our findings show that vitamin D(3) analogues may be suitable as novel anti-inflammatory agents for ALI.
authors: Pharmacological Research Department, Pharmaceuticals Development Research Laboratories, Teijin Institute for Bio-Medical Research, Hino, Tokyo 191-8512, Japan. ya.takano@teijin.co.jp
authors: Yasuhiro
authors: Y
authors: Takano
authors: Hiroaki
authors: H
authors: Mitsuhashi
authors: Koichi
authors: K
authors: Ueno
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000276:immunology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D006224:Cricetinae; D003907:Dexamethasone / Q000494:pharmacology; D004195:Disease Models, Animal; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D008647:Mesocricetus; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D020556:Neutrophil Infiltration / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D003907:Dexamethasone; D002117:Calcitriol; D002118:Calcium