title: Mitochondrial DNA protects against salt stress-induced cytochrome c-mediated apoptosis in yeast.
abstract: Here we report that budding yeast mitochondrial DNA protects against salt stress-induced apoptosis. Yeast cells lacking mitochondrial DNA (ρ(0)) are hypersensitive to salt stress-induced apoptosis, which is mediated by mitochondrial cytochrome c release. In addition, cytochrome c expression is downregulated upon salt stress, suggesting a transcriptionally regulated, homeostatic protection mechanism. The repression of cytochrome c transcription is mediated by transcription factor Mig1. Consistently, deletion of MIG1 induces cytochrome C transcription and yields ρ(0) cells that are more sensitive to salt stress. In summary, deletion of mitochondrial function leads to salt stress-induced transcriptional deregulation of cytochrome C, causing apoptosis in yeast.
authors: State Key Laboratory of Microbial Technology, Shandong University, Jinan, China.
authors: Qiuqiang
authors: Q
authors: Gao
authors: Qun
authors: Q
authors: Ren
authors: Liang-Chun
authors: LC
authors: Liou
authors: Xiaoming
authors: X
authors: Bao
authors: Zhaojie
authors: Z
authors: Zhang
mesh_terms: D017209:Apoptosis; D045304:Cytochromes c / Q000235:genetics / Q000378:metabolism*; D004272:DNA, Mitochondrial / Q000502:physiology*; D015966:Gene Expression Regulation, Fungal; D006706:Homeostasis; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000502:physiology*; D013312:Stress, Physiological
chemical_list: D004272:DNA, Mitochondrial; D045304:Cytochromes c