title: Devastating intracardiac and aortic thrombosis: a case report of apparent catastrophic antiphospholipid syndrome during liver transplantation.
abstract: Fewer than 80 cases of intracardiac thrombosis and intraoperative pulmonary thromboembolism during liver transplantation have been described. We present a patient who suffered an intraoperative fulminant intracardiac and aortic thrombosis and posthumously was found to have had high anticardiolipin immunoglobulin M concentration and markers of hyperfibrinolysis in preoperatively collected plasma. Hemostatic therapy in the presence of circulating antiphospholipid antibodies and the pathogenesis of a catastrophic antiphospholipid syndrome are discussed.
authors: Department of Anesthesiology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, FL 33136, USA. EGologorsky@med.miami.edu
authors: Edward
authors: E
authors: Gologorsky
authors: David M
authors: DM
authors: Andrews
authors: Angela
authors: A
authors: Gologorsky
authors: Venkata
authors: V
authors: Sampathi
authors: Lalitha
authors: L
authors: Sundararaman
authors: Radhika
authors: R
authors: Govindaswamy
authors: Yehuda
authors: Y
authors: Raveh
authors: Andreas G
authors: AG
authors: Tzakis
authors: Ernesto A
authors: EA
authors: Pretto
mesh_terms: D017153:Antibodies, Anticardiolipin / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis; D001011:Aorta / Q000503:physiopathology; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006331:Heart Diseases / Q000209:etiology / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D016031:Liver Transplantation; D008875:Middle Aged; D013927:Thrombosis / Q000209:etiology* / Q000503:physiopathology
chemical_list: D017153:Antibodies, Anticardiolipin; D007075:Immunoglobulin M