title: Cystatin C in pre-eclampsia.
abstract: OBJECTIVE
  To evaluate diagnostic value of cystatin C serum levels as alternative marker of renal function in pre-eclamsia (PE) and compare it with the traditional markers of renal function, creatinine and uric acid. In order to investigate the possible influence of inflammation on biochemical markers of renal function, serum levels of high sensitive CRP were measured (hsCRP).
  
  
  METHODS
  In this prospective study markers of kidney function were investigated in two groups of pregnant women: one with PE (n = 32) and the other of healthy pregnant women (n = 60). Serum cystatin C levels were measured as well as levels of traditional renal markers creatinin and uric acid and levels of high sensitive C-reactive protein.
  
  
  RESULTS
  Serum levels of cystatin C, creatinine and uric acid were significantly higher in the PE group than in the control group. Serum levels of hsCRP were higher in approximately the same number of patients with PE (50%) as in normal pregnancies (40%), without significant differences in CRP values between the two groups of patients.
  
  
  CONCLUSIONS
  Cystatin C serum level may have significant role as a marker of pre-eclampsia specially when used in combination with uric acid levels.
authors: Clinical Centre of Vojvodina, Department of Obstetrics and Gynaecology, Novi Sad, Serbia. aleksandranovakov@gmail.com
authors: Aleksandra
authors: A
authors: Novakov Mikic
authors: Velibor
authors: V
authors: Cabarkapa
authors: Aleksandra
authors: A
authors: Nikolic
authors: Daniela
authors: D
authors: Maric
authors: Snezana
authors: S
authors: Brkic
authors: Gorana
authors: G
authors: Mitic
authors: Marina
authors: M
authors: Ristic
authors: Zoran
authors: Z
authors: Stosic
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012372:ROC Curve; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D014527:Uric Acid; D003404:Creatinine