title: Insomnia: a therapeutic review for pharmacists.
abstract: OBJECTIVE
  To review the literature for the management of insomnia.
  
  
  METHODS
  MEDLINE/PUBMED searches (January 1950-June 2010) were conducted to identify pertinent English-language studies.
  
  
  METHODS
  All studies evaluating aspects of the treatment of insomnia.
  
  
  RESULTS
  Insomnia is a major public health problem requiring effective diagnosis and treatment. Treatment options include cognitive behavioral therapy as well as pharmacologic therapy. Benzodiazepine receptor-agonist modulators are considered first-line therapy in the treatment of chronic insomnia. A nonbenzodiazepine receptor-modulator option to improve sleep latency is ramelteon. Low-dose sedative antidepressants, such as quetiapine or olanzapine, may be used in the treatment of comorbid insomnia. Over-the-counter and herbal agents are not recommended.
  
  
  CONCLUSIONS
  Numerous medications being used in the management of insomnia have side effects that can limit their use and have a potential for drug interactions. Furthermore, some medications used in the treatment of insomnia do not have clinical trial data to support their use. Future studies are warranted to define second- and third-line agents in the management of insomnia.
authors: Creighton University School of Pharmacy and Health Professions (SPAHP), Omaha, Nebraska.
authors: Pamela
authors: P
authors: Foral
authors: Naresh
authors: N
authors: Dewan
authors: Mark
authors: M
authors: Malesker
mesh_terms: D015928:Cognitive Behavioral Therapy; D006801:Humans; D010595:Pharmacists; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*