title: Diagnostic classification of retinal nerve fiber layer measurement in myopic eyes: a comparison between time-domain and spectral-domain optical coherence tomography.
abstract: OBJECTIVE
  To evaluate and compare the diagnostic classification of retinal nerve fiber layer (RNFL) measurement between time-domain and spectral-domain optical coherence tomography (OCT) in myopic eyes.
  
  
  METHODS
  Prospective, observational study.
  
  
  METHODS
  A total of 97 eyes from 97 healthy myopic subjects were included. The RNFL in each eye was imaged sequentially with the Stratus OCT and the Cirrus HD-OCT (Carl Zeiss Meditec). With reference to the built-in normative database, the number of abnormal diagnostic classifications (borderline or outside normal limits) in each OCT device was analyzed and compared using the likelihood ratio chi-square test. Multiple logistic regression analysis was performed to evaluate factors associated with abnormal diagnostic classification.
  
  
  RESULTS
  The Cirrus HD-OCT classified a significantly higher percentage of eyes as outside normal limits/borderline in at least 1 clock hour (Stratus, 14.4%/24.8%; Cirrus, 21.6%/34.1%; all P < .01). RNFL measurement at 1 (23.6%) and 2 o'clock (23.5%) of all eyes was the most frequent location classified as abnormal by the Cirrus HD-OCT and the Stratus OCT, respectively. Eyes with smaller optic disc and longer axial length were more likely to have abnormal diagnostic classification.
  
  
  CONCLUSIONS
  In myopic eyes, Cirrus HD-OCT was more likely to have abnormal diagnostic classification than the Stratus OCT.
authors: Joint Shantou International Eye Center of Shantou University, Shantou University Medical College, Guangdong Province, People's Republic of China.
authors: Kun Liang
authors: KL
authors: Qiu
authors: Ming Zhi
authors: MZ
authors: Zhang
authors: Christopher Kai-Shun
authors: CK
authors: Leung
authors: Ri Ping
authors: RP
authors: Zhang
authors: Xue Hui
authors: XH
authors: Lu
authors: Geng
authors: G
authors: Wang
authors: Dennis Shun Chiu
authors: DS
authors: Lam
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005902:Glaucoma, Open-Angle / Q000145:classification / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D009216:Myopia / Q000150:complications*; D009412:Nerve Fibers / Q000473:pathology*; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000145:classification / Q000175:diagnosis* / Q000209:etiology; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods; D058609:Visual Field Tests; D014794:Visual Fields; D055815:Young Adult