title: Evaluation of insulin-like growth factor-1 in Indian growth hormone-deficient children on growth hormone therapy.
abstract: OBJECTIVE
  To evaluate the impact of recombinant human growth hormone therapy (GHT) on serum insulin-like growth factor 1 (IGF-1) concentrations in Indian children with growth hormone deficiency.
  
  
  METHODS
  Data on anthropometry and serum IGF-1 concentrations were collected from 28 growth hormone-deficient prepubertal children (8.6 ± 2.9 years) on growth hormone therapy, 6 monthly over the period of 2 years.
  
  
  RESULTS
  Height z-scores showed a steady increase from baseline to 24 months. However, IGF-1 z-scores showed a plateau after the first 6 months and then a small dip followed by a rise. The pattern of increase of IGF-1 z-scores was dissimilar to that of the height z-scores.
  
  
  CONCLUSIONS
  The change in serum IGF-1 z-scores in response to GHT in Indian children may not be a good indicator for monitoring growth hormone responsiveness.
authors: Growth and Pediatric Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India.
authors: Veena H
authors: VH
authors: Ekbote
authors: Vaishakhi T
authors: VT
authors: Rustagi
authors: Vaman V
authors: VV
authors: Khadilkar
authors: Anuradha V
authors: AV
authors: Khadilkar
authors: Shashi A
authors: SA
authors: Chiplonkar
mesh_terms: D002648:Child; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D007194:India; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I