title: [Association of STEAP4 genetic polymorphisms with insulin resistance in Uygur Chinese general population].
abstract: OBJECTIVE
  To explore the relationship between six-transmembrane epithelial antigen of prostate 4 (STEAP4) genetic polymorphisms and insulin resistance (IR) in Uygur Chinese general population.
  
  
  METHODS
  In this cross-sectional study on the metabolic diseases (e.g. obesity) among Uygur Chinese in Hetian, Xinjiang, China,from January to February 2007, 2127 Uygur individuals were enrolled. The sample size for IR subjects [homeostasis model assessment for insulin resistance (HOMA-IR) ≥2.3 65%] was 669, whereas that for non-IR controls was 664 (HOMA-IR≤1.335%). STEAP4 gene was sequenced in 50 Uygur Chinese individuals with IR (HOMA-IR≥2.3). The representative variations were selected from the population based on a r(2) cutoff of 0.8 and a minor allele frequency of >5% for case-control study.
  
  
  RESULTS
  Totally 16 variations including 10 novel variations (no reported in dbSNP) were identified in 50 Uygur individuals with IR. 7414 G/A (rs8122)(P/Pc=0.004/0.012)and 224A/G (rs1981529, Gly75Asp)(P/Pc=0.015/0.045)variations were significantly correlated with IR phenotype in Uygur subjects. As shown by multiple linear regression analysis, the mean values of waist circumference (WC) (P/Pc=0.032/0.256), body mass index (BMI) (P/Pc=0.004/0.032), HOMA-IR (P/Pc=0.010/0.08), and fasting insulin (P/Pc=0.023/0.184) among A (protection) allele carriers of rs8122 and the mean values of WC (P/Pc=0.005/0.040) and BMI (P/Pc=0.002/0.016) among G (protection) allele carriers of rs1981529 gradually declined. Haplotype 1 (rs8122 G- rs1981529 A- rs34741656 G) was significantly associated with a higher prevalence of IR (Permutation P=0.021).
  
  
  CONCLUSIONS
  STEAP4 genetic variations are likely to be associated with obesity-related insulin resistance in Uygur Chinese general population.
authors: Postdoctoral Research Station, School of Basic Medicine, CAMS and PUMC, Beijing 100005, China.
authors: Yan-ying
authors: YY
authors: Guo
authors: Ling
authors: L
authors: Zhou
authors: Xiao-guang
authors: XG
authors: Yao
authors: Zhi-tao
authors: ZT
authors: Yan
authors: Hong-mei
authors: HM
authors: Wang
authors: Wen-li
authors: WL
authors: Luo
authors: Yan
authors: Y
authors: Shen
authors: Nan-fang
authors: NF
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005006:Ethnicity / Q000235:genetics; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D010088:Oxidoreductases / Q000235:genetics*; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D008565:Membrane Proteins; D010088:Oxidoreductases; C503310:STEAP4 protein, human