title: Genome-wide association study identifies common variants associated with circulating vitamin E levels.
abstract: In genome-wide association studies (GWAS) of common genetic variants associated with circulating alpha- and gamma-tocopherol concentrations in two adult cohorts comprising 5006 men of European descent, we observed three loci associated with alpha-tocopherol levels, two novel single-nucleotide polymorphisms (SNPs), rs2108622 on 19pter-p13.11 (P= 1.7 × 10(-8)) and rs11057830 on 12q24.31 (P= 2.0 × 10(-8)) and confirmed a previously reported locus marked by rs964184 on 11q23.3 (P= 2.7 × 10(-10)). The three SNPs have been reported to be associated with lipid metabolism and/or regulation. We replicated these findings in a combined meta-analysis with two independent samples, P= 7.8 × 10(-12) (rs964184 on 11q23.3 near BUD13, ZNF259 and APOA1/C3/A4/A5), P= 1.4 × 10(-10) (rs2108622 on 19pter-p13.11 near CYP4F2) and P= 8.2 × 10(-9) (rs11057830 on 12q24.31 near SCARB1). Combined, these SNPs explain 1.7% of the residual variance in log alpha-tocopherol levels. In one of the two male GWAS cohorts (n= 992), no SNPs were significantly associated with gamma-tocopherol concentrations after including data from the replication sample for 71 independent SNPs with P< 1 × 10(-4) identified.
authors: Division of Cancer Epidemiology and Genetics and Core Genotyping Facility, National Cancer Institute, NIH, Bethesda, MD 20892, USA,
authors: Jacqueline M
authors: JM
authors: Major
authors: Kai
authors: K
authors: Yu
authors: William
authors: W
authors: Wheeler
authors: Hong
authors: H
authors: Zhang
authors: Marilyn C
authors: MC
authors: Cornelis
authors: Margaret E
authors: ME
authors: Wright
authors: Meredith
authors: M
authors: Yeager
authors: Kirk
authors: K
authors: Snyder
authors: Stephanie J
authors: SJ
authors: Weinstein
authors: Alison
authors: A
authors: Mondul
authors: Heather
authors: H
authors: Eliassen
authors: Mark
authors: M
authors: Purdue
authors: Aditi
authors: A
authors: Hazra
authors: Catherine A
authors: CA
authors: McCarty
authors: Sara
authors: S
authors: Hendrickson
authors: Jarmo
authors: J
authors: Virtamo
authors: David
authors: D
authors: Hunter
authors: Stephen
authors: S
authors: Chanock
authors: Peter
authors: P
authors: Kraft
authors: Demetrius
authors: D
authors: Albanes
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000517:prevention & control; D020641:Polymorphism, Single Nucleotide; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood*; D044465:White People / Q000235:genetics
chemical_list: D014810:Vitamin E