title: [Advanced gallbladder cancer that showed complete response to gemcitabine plus S-1 chemotherapy].
abstract: A 57-year-old man with advanced gallbladder cancer and accompanying hepatic, colonic and duodenal invasion and para-aortic lymph node metastasis was referred to our hospital. Gemcitabine plus S-1 administration was chosen. Gemcitabine was administered intravenously at a dose of 1000 mg/m(2) on days 1 and 15, and repeated every 4 weeks. S-1 was administered orally at a dose of 40 mg/m(2) b.i.d. on days 1-14. Chemotherapy was effective for the primary gallbladder tumor and lymph node metastasis. The primary tumor and metastatic lymph nodes were shown to have disappeared by a FDG-PET CT study after 10 courses of chemotherapy. Informed consent was obtained prior to performing surgery of the primary lesion. Pathological examination showed fibrosis and a small focus of residual cancer in the resected gallbladder. Complete resection was achieved as all the margins were negative. The findings suggest that gemcitabine plus S-1 treatment may be effective against advanced gallbladder cancer.
authors: Department of Internal Medicine, Saiseikai Central Hospital.
authors: Maiko
authors: M
authors: Takita
authors: Eisuke
authors: E
authors: Iwasaki
authors: Ken
authors: K
authors: Hatogai
authors: Ryohei
authors: R
authors: Kishino
authors: Eri
authors: E
authors: Seki
authors: Motoko
authors: M
authors: Izumiya
authors: Norio
authors: N
authors: Maeda
authors: Atsushi
authors: A
authors: Nakazawa
authors: Akira
authors: A
authors: Mizuki
authors: Kan
authors: K
authors: Handa
authors: Yutaka
authors: Y
authors: Shimoyama
authors: Kiyoshi
authors: K
authors: Mukai
authors: Hajime
authors: H
authors: Higuchi
authors: Hiromasa
authors: H
authors: Takaishi
authors: Toshifumi
authors: T
authors: Hibi
authors: Nobuhiro
authors: N
authors: Tsukada
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D005706:Gallbladder Neoplasms / Q000188:drug therapy*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine