title: The levels of bone turnover markers in Chinese postmenopausal women: Peking Vertebral Fracture study.
abstract: OBJECTIVE
  The aim of this study was to evaluate serum N-aminoterminal propeptide of type I collagen (P1NP), C-terminal telopeptide of type I collagen (β-CTX), and vitamin D status in healthy Chinese postmenopausal women. The study was also designed to investigate their possible relationships with osteoporosis phenotypes.
  
  
  METHODS
  A community-based population of 1,724 postmenopausal women in Beijing was randomly selected. Serum bone turnover markers and 25-hydroxyvitamin D [25(OH)D] were tested by an automated Roche electrochemiluminescence system. Dual-energy x-ray absorptiometry was used to measure bone mineral density (BMD).
  
  
  RESULTS
  The mean (SD) values of serum β-CTX and P1NP were 0.439 (0.210) and 56.7 (27.9) ng/mL, respectively. The 25(OH)D level of postmenopausal women in Beijing was remarkably low (13.2 ± 5.4 ng/mL). Serum β-CTX and P1NP levels were negatively correlated with BMDs of lumbar spine, femoral neck, and total hip (all P < 0.01). The cubic regression model better fitted the relationships of BMD and bone turnover markers. Serum β-CTX levels were significantly higher in women with sustained osteoporotic fracture or vertebral fracture (P = 0.006 and 0.012, respectively). No association between P1NP and fracture or vertebral fracture was detected. The same situation applied to 25(OH)D. 25(OH)D was negatively correlated with β-CTX and P1NP (r = -0.073 and -0.088, P = 0.002 and <0.001, respectively).
  
  
  CONCLUSIONS
  Serum β-CTX and P1NP levels were negatively correlated with BMD. β-CTX was significantly higher in postmenopausal women with sustained fracture or vertebral fracture. Vitamin D deficiency was highly prevalent in postmenopausal women in Beijing.
authors: Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
authors: Jing
authors: J
authors: Zhao
authors: Weibo
authors: W
authors: Xia
authors: Min
authors: M
authors: Nie
authors: Xin
authors: X
authors: Zheng
authors: Qiuping
authors: Q
authors: Wang
authors: Xiran
authors: X
authors: Wang
authors: Wenbo
authors: W
authors: Wang
authors: Zhiwei
authors: Z
authors: Ning
authors: Wei
authors: W
authors: Huang
authors: Yan
authors: Y
authors: Jiang
authors: Mei
authors: M
authors: Li
authors: Ou
authors: O
authors: Wang
authors: Xiaoping
authors: X
authors: Xing
authors: Yue
authors: Y
authors: Sun
authors: Lianmei
authors: L
authors: Luo
authors: Shuli
authors: S
authors: He
authors: Wei
authors: W
authors: Yu
authors: Qiang
authors: Q
authors: Lin
authors: Yu
authors: Y
authors: Pei
authors: Fan
authors: F
authors: Zhang
authors: Youxia
authors: Y
authors: Han
authors: Yanmin
authors: Y
authors: Tong
authors: Ying
authors: Y
authors: Che
authors: Ruixin
authors: R
authors: Shen
authors: Yingying
authors: Y
authors: Hu
authors: Xueying
authors: X
authors: Zhou
authors: Ling
authors: L
authors: Xu
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology; D002681:China; D024042:Collagen Type I / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D058866:Osteoporotic Fractures / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D017698:Postmenopause / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D012044:Regression Analysis; D016103:Spinal Fractures / Q000097:blood / Q000209:etiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide; D014807:Vitamin D; C104450:25-hydroxyvitamin D