title: Discovery of selective indole-based prostaglandin D₂ receptor antagonist.
abstract: A series of N-benzoyl-2-methylindole-3-acetic acids were synthesized and biologically evaluated as prostaglandin (PG) D₂ receptor antagonists. Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure-activity relationship study is presented.
authors: Minase Research Institute, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan. iwahashi@ono.co.jp
authors: Maki
authors: M
authors: Iwahashi
authors: Atsushi
authors: A
authors: Shimabukuro
authors: Takahiro
authors: T
authors: Onoda
authors: Yoko
authors: Y
authors: Matsunaga
authors: Yutaka
authors: Y
authors: Okada
authors: Ryoji
authors: R
authors: Matsumoto
authors: Fumio
authors: F
authors: Nambu
authors: Hisao
authors: H
authors: Nakai
authors: Masaaki
authors: M
authors: Toda
mesh_terms: D000818:Animals; D016466:CHO Cells; D002199:Capillary Permeability / Q000187:drug effects*; D003228:Conjunctiva / Q000098:blood supply; D006224:Cricetinae; D003412:Cricetulus; D055808:Drug Discovery; D006168:Guinea Pigs; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors* / Q000378:metabolism*
chemical_list: D007211:Indoles; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C036293:prostaglandin D2 receptor