title: Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring Study.
abstract: OBJECTIVE
  Our aim was to determine whether plasma adiponectin levels were an independent predictor of coronary heart disease (CHD) risk.
  
  
  RESULTS
  Plasma adiponectin levels were measured in 3188 male and female participants from cycle 6 of the Framingham offspring Study (mean age: 57 years in both men and women; BMI: 28.5 kg/m(2) in men and 27.3 kg/m(2) in women), using a novel fully automated assay. Plasma adiponectin levels (median [25th percentile, 75th percentile]) were significantly higher in female than in male CHD-free subjects (14.8 [10.7,20.5] μg/ml versus 9.0 [7.0,12.2] μg/ml, p<0.001). Participants were followed for a mean of 7.5 years. After adjustment for age, BMI, smoking status, systolic blood pressure, treatment for hypertension, diabetes, use of cholesterol-lowering medication, total cholesterol level, high-density lipoprotein cholesterol level, and C-reactive protein levels, a higher plasma adiponectin level was a significant predictor of lower risk of future CHD events (n=117) in men (HR 0.49, p<0.0022). A similar trend was observed in women, but was no longer significant after multivariate adjustments.
  
  
  CONCLUSIONS
  Our data indicate that plasma adiponectin levels are an independent predictor of CHD in Caucasian men initially free of CHD.
authors: Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
authors: Masumi
authors: M
authors: Ai
authors: Seiko
authors: S
authors: Otokozawa
authors: Bela F
authors: BF
authors: Asztalos
authors: Charles C
authors: CC
authors: White
authors: L Adrienne
authors: LA
authors: Cupples
authors: Katsuyuki
authors: K
authors: Nakajima
authors: Stefania
authors: S
authors: Lamon-Fava
authors: Peter W
authors: PW
authors: Wilson
authors: Yuji
authors: Y
authors: Matsuzawa
authors: Ernst J
authors: EJ
authors: Schaefer
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D015854:Up-Regulation
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers