title: Retinal pigment epithelial tear after intravitreous triamcinolone acetonide injection for fibrovascular pigment epithelial detachment.
abstract: A 78-year-old woman was diagnosed with fibrovascular pigment epithelial detachment (PED) associated with age-related macular degeneration (AMD) affecting both eyes. Due to decreased vision in her left eye (20/2000) and disease progression, the patient received 4 mg of triamcinolone acetonide (TA) by intravitreal injection into her left eye. There were no immediate post-injection complications in the left eye. However, one week later, a retinal pigment epithelial (RPE) tear, temporal-inferior to the fovea in the left eye, was noted and confirmed by fundus photography, fluorescein angiography and optical coherence tomography. In contrast, there no similar RPE tear occurred in her right eye after treated several times by intravitreous bevacizumab injection. Not only anti-vascular endothelium growth factor agents, but also intravitreal TA when used to treat AMD with PED, would seem to induce a RPE tear in the absence of previous or concurrent adjuvant therapy. Further investigations are required to confirm the mechanism by which the RPE tear occurs.
authors: Department of Ophthalmology, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. wpc@cgmh.org.tw
authors: Pei-Chang
authors: PC
authors: Wu
authors: Yung-Jen
authors: YJ
authors: Chen
authors: Hsi-Kung
authors: HK
authors: Kuo
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D010857:Pigment Epithelium of Eye / Q000187:drug effects*; D012163:Retinal Detachment / Q000188:drug therapy*; D012167:Retinal Perforations / Q000139:chemically induced*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014222:Triamcinolone Acetonide