title: Therapeutic potential of peptide toxins that target ion channels.
abstract: Traditional healthcare systems in China, India, Greece and the Middle East have for centuries exploited venomous creatures as a resource for medicines. This review focuses on one class of pharmacologically active compounds from venom, namely peptide toxins that target ion channels. We highlight their therapeutic potential and the specific channels they target. The field of therapeutic application is vast, including pain, inflammation, cancer, neurological disorders, cardioprotection, and autoimmune diseases. One of these peptides is in clinical use, and many others are in various stages of pre-clinical and clinical development.
authors: Centre de Recherches en Oncologie Biologique et Oncopharmacologie (CRO2), Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine la Timone, Université de la Méditerranée, Marseille, France. evelyne.beraud@univmed.fr
authors: Evelyne
authors: E
authors: Beraud
authors: K George
authors: KG
authors: Chandy
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy*; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007473:Ion Channels / Q000037:antagonists & inhibitors; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy*; D009422:Nervous System Diseases / Q000188:drug therapy*; D013111:Spider Venoms / Q000494:pharmacology / Q000627:therapeutic use*; D014118:Toxins, Biological / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D002316:Cardiotonic Agents; D007473:Ion Channels; D013111:Spider Venoms; D014118:Toxins, Biological