title: Risks of colon and rectal adenomas are differentially associated with anthropometry throughout life: the French E3N prospective cohort.
abstract: BACKGROUND
  Associations between adult anthropometry and risk of colorectal neoplasms are well established. However, whereas body mass in infancy and childhood has been associated with risk of some cancers, little is known about potential associations with colorectal neoplasms. The authors investigated associations between colorectal adenoma risk and lifetime anthropometry, in an attempt to better understand the relationships between anthropometric features and colorectal carcinogenesis.
  
  
  METHODS
  Among the 17 391 women of the French E3N cohort who underwent a colonoscopy during follow-up (1993-2002), 1408 developed a first colorectal adenoma. Associations were estimated with Cox multivariate proportional hazard regression models.
  
  
  RESULTS
  Left colon adenoma risk was associated with high birth weight [hazard ratio (HR) high vs median = 1.21; 95% confidence interval (95% CI): 1.00-1.47, P(trend) = 0.03] and large adult body shape (HR = 1.28; 95% CI: 1.04-1.56, P(trend) = 0.02). A large versus small body shape at age 8 years and at menarche were associated with a decreased rectal adenoma risk [HR = 0.68; 95% CI: 0.49-0.95, P(trend) = 0.01 and 0.73 (0.53-1.01), P(trend) = 0.05, respectively]. Except for a positive association with large vs median birth weight, no anthropometric characteristic was associated with right colon adenoma risk. Associations did not differ between advanced and non-advanced adenomas.
  
  
  CONCLUSIONS
  These findings suggest that early life events may influence early stages of colorectal carcinogenesis and add to the evidence of differential pathways of carcinogenesis in the right colon, left colon and rectum.
authors: INSERM, CESP Centre for Research in Epidemiology and Population Health, UMRS 1018, Team 9, Institut Gustave Roussy, F-94805 Villejuif, France.
authors: Sophie
authors: S
authors: Morois
authors: Sylvie
authors: S
authors: Mesrine
authors: Femke
authors: F
authors: Besemer
authors: Marine
authors: M
authors: Josset
authors: Françoise
authors: F
authors: Clavel-Chapelon
authors: Marie-Christine
authors: MC
authors: Boutron-Ruault
mesh_terms: D000236:Adenoma / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D000328:Adult; D000368:Aged; D000886:Anthropometry; D001724:Birth Weight / Q000502:physiology; D049628:Body Size / Q000502:physiology; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D005602:France; D006801:Humans; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D012307:Risk Factors; D011795:Surveys and Questionnaires