title: ent-Abietane diterpenoids from Isodon xerophilus.
abstract: Three new ent-abietanoids, named xerophilusins XIV-XVI, and four known analogues, as well as four known chemical constituents were isolated from the leaves of Isodon xerophilus. Their structures were elucidated by extensive spectroscopic studies, and comparison with literature data. In addition, the cytotoxic activity of the ent-abietanoids against chronic myelogenous leukemia (K562), stomach adenocarcinoma (MKN45), and hepatocellular carcinoma (HepG2) human cell lines was investigated and no activities were observed.
authors: Scientific Research Center, Chengdu Medical College, Chengdu 610083, China.
authors: Li Mei
authors: LM
authors: Li
authors: Jian Xin
authors: JX
authors: Pu
authors: Wei Lie
authors: WL
authors: Xiao
authors: Han Dong
authors: HD
authors: Sun
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D013057:Spectrum Analysis
chemical_list: D045784:Abietanes; D010936:Plant Extracts