title: Aromatic compounds from the halotolerant fungal strain of Wallemia sebi PXP-89 in a hypersaline medium.
abstract: A new cyclopentanopyridine alkaloid, 3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (1), together with 11 known aromatic compounds were isolated from the secondary metabolites of the halotolerant fungal strain Wallemia sebi PXP-89 in 10% NaCl. Their structures including the absolute configurations of (2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (2), (2R,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (3), and (S)-3-hydroxy-4-(4-hydroxyphenyl)-2-one (4) were elucidated by spectroscopic analysis and a modified Mosher's method. Compound 1 exhibited antimicrobial activity against Enterobacter aerogenes with a MIC of 76.7 μM. The absolute configurations of compounds 2-4 were determined for the first time.
authors: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
authors: Xiao-Ping
authors: XP
authors: Peng
authors: Yi
authors: Y
authors: Wang
authors: Pei-Pei
authors: PP
authors: Liu
authors: Kui
authors: K
authors: Hong
authors: Hao
authors: H
authors: Chen
authors: Xia
authors: X
authors: Yin
authors: Wei-Ming
authors: WM
authors: Zhu
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000378:metabolism*; D021902:Enterobacter aerogenes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011728:Pyridones / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: C562036:3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta(b)pyridin-7-one; D000470:Alkaloids; D000900:Anti-Bacterial Agents; D011728:Pyridones