title: Muller's Nobel lecture on dose-response for ionizing radiation: ideology or science?
abstract: In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his Nobel Prize Lecture reveals that Muller knew the results and implications of a recently completed study at the University of Rochester under the direction of Stern, which directly contradicted his Nobel Prize Lecture. This finding is of historical importance since Muller's Nobel Lecture gained considerable international attention and is a turning point in the acceptance of the linearity model in risk assessment for germ cell mutations and carcinogens.
authors: Environmental Health Sciences, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA. edwardc@schoolph.umass.edu
authors: Edward J
authors: EJ
authors: Calabrese
mesh_terms: D008192:Deception; D004307:Dose-Response Relationship, Radiation; D018095:Germ-Line Mutation / Q000528:radiation effects; D049673:History, 20th Century; D006801:Humans; D016014:Linear Models; D009613:Nobel Prize; D011832:Radiation Injuries / Q000266:history*; D011839:Radiation, Ionizing; D018570:Risk Assessment / Q000379:methods