title: Diffusion-weighted imaging and pathological correlation in pediatric medulloblastomas-"They are not always restricted!".
abstract: BACKGROUND
  Some investigators have suggested that medulloblastomas can be distinguished from other cerebellar neoplasms by demonstrating "restricted diffusion" on the Apparent Diffusion Coefficient (ADC) map obtained from diffusion-weighted imaging (DWI) sequences on magnetic resonance imaging. Previous authors have postulated that this observed restricted diffusion is a reflection of very high cell density. There has been a tendency to assert that pediatric medulloblastoma uniformly demonstrates restricted diffusion on DWI. However, our clinical observation has been that there are pediatric medulloblastomas that exhibit normal or even increased diffusion on DWI. The current study was undertaken primarily to determine whether restricted diffusion is uniformly present in pediatric medulloblastoma and secondly to look for pathological features that might distinguish medulloblastomas with and without restricted diffusion.
  
  
  METHODS
  The DWI characteristics of pathologically confirmed medulloblastomas diagnosed at our institution were retrospectively reviewed. The ADC was obtained in two non-overlapping, solid, non-hemorrhagic, non-necrotic regions of tumor and averaged. An ADC below 1 × 10(-3) mm(2)/s was considered to represent restricted diffusion. A detailed pathologic review of each tumor was conducted.
  
  
  RESULTS
  Ten cases of medulloblastoma were reviewed, of which two demonstrated average ADCs above 1 × 10(-3) mm(2)/s (1.223 and 1.169 × 10(-3) mm(2)/s, respectively), indicating no restricted diffusion. Pathologic review revealed that both of these non-restricting cases displayed a lack of reticulin deposition by light microscopy.
  
  
  CONCLUSIONS
  DWI does not appear to be an entirely reliable means of distinguishing medulloblastomas from other cerebellar neoplasms. Histologically, restricted diffusion in medulloblastomas may be related to reticulin deposition.
authors: Division of Pediatric Neurosurgery, Department of Surgery, University of British Columbia and British Columbia's Children's Hospital, Vancouver, Canada.
authors: Shibu
authors: S
authors: Pillai
authors: Ash
authors: A
authors: Singhal
authors: Angela T
authors: AT
authors: Byrne
authors: Chris
authors: C
authors: Dunham
authors: D Douglas
authors: DD
authors: Cochrane
authors: Paul
authors: P
authors: Steinbok
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003388:Cranial Fossa, Posterior / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008527:Medulloblastoma / Q000175:diagnosis* / Q000473:pathology; D019292:Skull Base Neoplasms / Q000175:diagnosis* / Q000473:pathology