title: Adverse effects in wild fish living downstream from pharmaceutical manufacture discharges.
abstract: A set of biochemical and histological responses was measured in wild gudgeon collected upstream and downstream of urban and pharmaceutical manufacture effluents. These individual end-points were associated to fish assemblage characterisation. Responses of biotransformation enzymes, neurotoxicity and endocrine disruption biomarkers revealed contamination of investigated stream by a mixture of pollutants. Fish from sampled sites downstream of the industrial effluent exhibited also strong signs of endocrine disruption including vitellogenin induction, intersex and male-biased sex-ratio. These individual effects were associated to a decrease of density and a lack of sensitive fish species. This evidence supports the hypothesis that pharmaceutical compounds discharged in stream are involved in recorded endocrine disruption effects and fish population disturbances and threaten disappearance of resident fish species. Overall, this study gives argument for the utilisation of an effect-based monitoring approach to assess impacts of pharmaceutical manufacture discharges on wild fish populations.
authors: Institut National de l'Environnement Industriel et des Risques (INERIS), Unité d'Ecotoxicologie in vitro et in vivo, Verneuil-en-Halatte, France. Wilfried.Sanchez@ineris.fr
authors: Wilfried
authors: W
authors: Sanchez
authors: William
authors: W
authors: Sremski
authors: Benjamin
authors: B
authors: Piccini
authors: Olivier
authors: O
authors: Palluel
authors: Emmanuelle
authors: E
authors: Maillot-Maréchal
authors: Stéphane
authors: S
authors: Betoulle
authors: Ali
authors: A
authors: Jaffal
authors: Sélim
authors: S
authors: Aït-Aïssa
authors: François
authors: F
authors: Brion
authors: Eric
authors: E
authors: Thybaud
authors: Nathalie
authors: N
authors: Hinfray
authors: Jean-Marc
authors: JM
authors: Porcher
mesh_terms: D000818:Animals; D003530:Cyprinidae / Q000502:physiology*; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism; D012734:Disorders of Sex Development / Q000139:chemically induced / Q000453:epidemiology; D004345:Drug Industry; D064420:Drug-Related Side Effects and Adverse Reactions; D052244:Endocrine Disruptors / Q000633:toxicity; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism; D006066:Gonads / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D004364:Pharmaceutical Preparations / Q000032:analysis; D045483:Rivers / Q000737:chemistry; D012744:Sex Ratio; D014819:Vitellogenins / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*
chemical_list: D052244:Endocrine Disruptors; D004364:Pharmaceutical Preparations; D014819:Vitellogenins; D014874:Water Pollutants, Chemical; D019363:Cytochrome P-450 CYP1A1; D051544:Cytochrome P-450 CYP3A; D005982:Glutathione Transferase