title: Effects of 5 rounds of mass drug administration with diethylcarbamazine and albendazole on filaria-specific IgG4 titers in urine: 6-year follow-up study in Sri Lanka.
abstract: ELISA for filaria-specific IgG4 in urine (urine ELISA) was applied to children in 7 schools in Sri Lanka, before and after 5 rounds of annual mass drug administration (MDA). The pre-treatment IgG4 prevalence in 2002 was 3.20%, which decreased to 0.91% in 2003 after the first MDA (P<0.001), and finally to 0.36% in 2007 after the 5th MDA. Among 5-10 year-old children, the prevalence decreased from 3.37% in 2002 to 0.51% in 2003 (P=0.009). A pattern of IgG4 titer distribution according to age and its yearly change could also provide useful information in drug efficacy analysis. In 2008, new samples from eleven 2006/07 urine ELISA-positive students and their family members (total n=56) were examined by ICT antigen test, microfilaria test, and urine ELISA. No infection was confirmed among them. Urine ELISA will be useful in monitoring elimination/resurgence in a post-MDA low endemic situation.
authors: Department of Parasitology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan. macitoh@aichi-med-u.ac.jp
authors: Makoto
authors: M
authors: Itoh
authors: Mirani V
authors: MV
authors: Weerasooriya
authors: Thishan C
authors: TC
authors: Yahathugoda
authors: Hidekazu
authors: H
authors: Takagi
authors: Wilfred A
authors: WA
authors: Samarawickrema
authors: Fumiaki
authors: F
authors: Nagaoka
authors: Eisaku
authors: E
authors: Kimura
mesh_terms: D000293:Adolescent; D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005260:Female; D005368:Filariasis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000652:urine*; D005369:Filaricides / Q000008:administration & dosage* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology / Q000652:urine*; D008297:Male; D015995:Prevalence; D013188:Sri Lanka / Q000453:epidemiology; D014958:Wuchereria bancrofti / Q000276:immunology*; D055815:Young Adult
chemical_list: D000947:Antigens, Helminth; D005369:Filaricides; D007074:Immunoglobulin G; D015766:Albendazole; D004049:Diethylcarbamazine