title: Digital mammography screening: weighing reduced mortality against increased overdiagnosis.
abstract: OBJECTIVE
  Digital mammography has been shown to increase the detection of ductal carcinoma in situ (DCIS) compared to screen-film mammography. The benefits and risks of such an increase were assessed.
  
  
  METHODS
  Breast cancer detection rates were compared between 502,574 screen-film and 83,976 digital mammograms performed between 2004 and 2006 among Dutch screening participants. The detection rates were then modeled using a baseline model and two extreme models that respectively assumed a high rate of progression and no progression of preclinical DCIS to invasive cancer. With these models, breast cancer mortality and overdiagnosis were predicted.
  
  
  RESULTS
  The DCIS detection rate was significantly higher at digital mammography (1.2 per 1000 mammograms (95% C.I. 1.0-1.5)) than at screen-film mammography (0.7 per 1000 mammograms (95% C.I. 0.6-0.7)). Consequently, 287 (range progressive- non progressive model: 1-598) extra breast cancer deaths per 1,000,000 women (a 4.4% increase) were predicted to be prevented. An extra 401 (range: 165-2271) cancers would be overdiagnosed (a 21% increase).
  
  
  CONCLUSIONS
  Modeling predicted that digital mammography screening would further reduce breast cancer mortality by 4.4%, at a 21% increased overdiagnosis rate. The consequences of digital screening, however, are sensitive to underlying assumptions on the natural history of DCIS.
authors: Erasmus MC, Department of Public Health, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. r.degelder@erasmusmc.nl
authors: Rianne
authors: R
authors: de Gelder
authors: Jacques
authors: J
authors: Fracheboud
authors: Eveline A M
authors: EA
authors: Heijnsdijk
authors: Gerard
authors: G
authors: den Heeten
authors: André L M
authors: AL
authors: Verbeek
authors: Mireille J M
authors: MJ
authors: Broeders
authors: Gerrit
authors: G
authors: Draisma
authors: Harry J
authors: HJ
authors: de Koning
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000401:mortality; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis* / Q000401:mortality; D016001:Confidence Intervals; D003951:Diagnostic Errors; D018450:Disease Progression; D055088:Early Detection of Cancer / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D015994:Incidence; D008327:Mammography / Q000295:instrumentation* / Q000379:methods; D008875:Middle Aged; D009426:Netherlands; D018570:Risk Assessment / Q000379:methods