title: Role of ADARs in mouse development.
abstract: RNA editing by deamination of adenosine to inosine (A-to-I editing) is a physiologically important posttranscriptional mechanism that can regulate expression of genes by modifying their transcripts. A-to-I editing is mediated by adenosine deaminases acting on RNA (ADAR) that can catalytically exchange adenosines to inosines, with varying efficiency, depending on the structure of the RNA substrates. Significant progress in understanding the biological function of mammalian ADARs has been made in the past decade by the creation and analysis of gene-targeted mice with disrupted or modified ADAR alleles. These studies have revealed important roles of ADARs in neuronal and hematopoietic tissue during embryonic and postnatal stages of mouse development.
authors: St. Vincent's Institute of Medical Research and Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, VIC 3065, Australia.
authors: Carl R
authors: CR
authors: Walkley
authors: Brian
authors: B
authors: Liddicoat
authors: Jochen C
authors: JC
authors: Hartner
mesh_terms: D000243:Adenosine Deaminase / Q000502:physiology*; D020087:Alu Elements; D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology; D000818:Animals; D047108:Embryonic Development; D006410:Hematopoiesis; D051379:Mice; D035683:MicroRNAs / Q000235:genetics; D017393:RNA Editing; D016601:RNA-Binding Proteins
chemical_list: D035683:MicroRNAs; D016601:RNA-Binding Proteins; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase