title: Infrared assisted production of 3,4-dihydro-2(1H)-pyridones in solvent-free conditions.
abstract: A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum's acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50-75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed.
authors: Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán-UNAM, Estado de México, 54754, Mexico; E-Mails: olinoco@yahoo.com.mx (M.O.N.); atlanta126@hotmail.com (J.O.M.); garroyo@unam.mx (G.A.A.).
authors: M Olivia
authors: MO
authors: Noguez
authors: Vanessa
authors: V
authors: Marcelino
authors: Hortensia
authors: H
authors: Rodríguez
authors: Osnieski
authors: O
authors: Martín
authors: Joel O
authors: JO
authors: Martínez
authors: Gabriel A
authors: GA
authors: Arroyo
authors: Francisco J
authors: FJ
authors: Pérez
authors: Margarita
authors: M
authors: Suárez
authors: René
authors: R
authors: Miranda
mesh_terms: D055772:Green Chemistry Technology; D007259:Infrared Rays; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011728:Pyridones / Q000138:chemical synthesis / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D011728:Pyridones; D012997:Solvents