title: The use of photosensitisers in acne treatment.
abstract: Whereas the standard approach to the treatment of acne vulgaris has involved both systemic and topical antibiotics and topical agents such as benzoyl peroxide, problems exist due to side effects, drug resistance and lack of compliance. The photoantimicrobial approach offers a rapid treatment for large areas of afflicted dermis, based on the generation of reactive oxygen species in situ. Various chemical types are available as a topical modality, both in respect of the photosensitising agent and the activating light source, the suggested therapeutic approach requiring medical supervision. Due to a novel mode of action, the use of photosensitisers constitutes a convenient option against drug-resistant bacteria.
authors: School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, United Kingdom. mark_wainwright@hotmail.com
authors: Mark
authors: M
authors: Wainwright
authors: Helen
authors: H
authors: Smalley
authors: Chris
authors: C
authors: Flint
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000622:Aminolevulinic Acid / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry / Q000627:therapeutic use; D010640:Phenothiazines / Q000737:chemistry / Q000627:therapeutic use; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D014466:Ultraviolet Rays
chemical_list: D010640:Phenothiazines; D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid; C031637:phenothiazine; D007208:Indocyanine Green