title: Novel roles of complement in T effector cell regulation.
abstract: Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immune modulation during a T cell response.
authors: Department of Medicine, Recanati Miller Transplant Institute and Immunology Institute, Mount Sinai School of Medicine, New York, USA.
authors: Peter S
authors: PS
authors: Heeger
authors: Claudia
authors: C
authors: Kemper
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral; D051916:Membrane Cofactor Protein / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology*; D014181:Transplantation Immunology
chemical_list: D051916:Membrane Cofactor Protein; D003165:Complement System Proteins