title: Cooperative crosslink (un)binding in slowly driven bundles of semiflexible filaments.
abstract: Combining simulations and theory I study the interplay between bundle elastic degrees of freedom and crosslink binding propensity. By slowly driving bundles into a deformed configuration, and depending on the mechanical stiffness of the crosslinking agent, the binding affinity is shown to display a sudden and discontinuous drop. This indicates a cooperative unbinding process that involves the crossing of a free-energy barrier. Choosing the proper crosslinker therefore not only allows us to change the composite elastic properties of the bundle but also the relevant time scales which can be tuned from the single crosslink binding rate to the much longer escape time over the free-energy barrier.
authors: Institute for Theoretical Physics, Georg-August University of Göttingen, Göttingen, Germany.
authors: Claus
authors: C
authors: Heussinger
mesh_terms: D001696:Biomechanical Phenomena; D001704:Biopolymers / Q000737:chemistry*; D004548:Elasticity; D007700:Kinetics; D013696:Temperature
chemical_list: D001704:Biopolymers