title: Interleukin-1 beta, interleukin-6 and TGF-beta in follicular tissue of impacted third molars.
abstract: The clinical evaluation and management of impacted third molars remain challenging. The aim of the present study was to investigate possible associations between follicular tissue cytokines and radiographic manifestations of impacted third molar. The population included 72 patients who underwent surgical extraction of impacted third molars. All these patients underwent a preliminary panoramic radiograph. Levels of interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and transforming growth factor beta (TGF-β) in tissue extracts were determined using ELISA. There were no significant differences between bony and tissue impaction as regards IL-1β, IL-6 and TGF-β levels. Moreover, the same results were obtained as far as the amount of pericoronal space and the presence or absence of a history of pericoronitis are concerned. These results suggest that radiographic findings or a history of pericoronitis are not associated with levels of expression of pro-inflammatory cytokines in patients undergoing surgical removal of impacted third molars. However, further studies are needed to address the possibility of variability during disease progression.
authors: Department of Oral and Maxillofacial Surgery, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Ali Hossein
authors: AH
authors: Mesgarzadeh
authors: Ali Akbar
authors: AA
authors: Abolfathi
authors: Saeed
authors: S
authors: Dastgiri
authors: Maghsod
authors: M
authors: Shaaker
authors: Amir Mansour
authors: AM
authors: Vatankhah
authors: Shiva
authors: S
authors: Solehakahnamoiee
authors: Masoud
authors: M
authors: Darabi
mesh_terms: D000293:Adolescent; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008964:Molar, Third / Q000378:metabolism*; D010497:Pericoronitis / Q000378:metabolism; D014095:Tooth, Impacted / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D055815:Young Adult
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D016212:Transforming Growth Factor beta