title: The Cox-2 -1195 G > A polymorphism and cancer risk: a meta-analysis of 25 case-control studies.
abstract: Cyclooxygenase 2 (Cox-2, a rate-limiting enzyme in the conversion of arachidonic acid to prostanoids) has been implicated in several physiological and pathological processes, and it has been reported that polymorphisms in the regulatory region of Cox-2 might influence its expression, contributing to the interindividual susceptibility to cancer. However, results from published studies on the association between the Cox-2 -1195G > A polymorphism and the risk of cancer are conflicting. We performed a meta-analysis based on 25 case-control studies, including a total of 9482 cancer cases and 12 206 controls to derive a more precise estimation of the association and its possible influence on cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The overall results indicated that the variant genotypes moderately increased risk of cancer (AA/AG versus GG, OR = 1.15, 95% CI: 1.02-1.31). In the stratified analysis for the -1195G > A polymorphism, a proximate association was observed in Asian populations (AA/AG versus GG, OR = 1.28, 95% CI: 1.12-1.46), but no significant association except for oesophageal cancer and 'others' was found when stratified by cancer type. In conclusion, our meta-analysis indicates that -1195G > A of Cox-2 is a low penetration risk factor for cancer.
authors: Central Laboratory of Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China.
authors: Zhipeng
authors: Z
authors: Tang
authors: Zhen-Lin
authors: ZL
authors: Nie
authors: Yuqin
authors: Y
authors: Pan
authors: Lirong
authors: L
authors: Zhang
authors: Lei
authors: L
authors: Gao
authors: Qian
authors: Q
authors: Zhang
authors: Lili
authors: L
authors: Qu
authors: Bangshun
authors: B
authors: He
authors: Guoqi
authors: G
authors: Song
authors: Ying
authors: Y
authors: Zhang
authors: Shukui Wang
mesh_terms: D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human