title: Leber hereditary optic neuropathy mimicking neuromyelitis optica.
abstract: Leber hereditary optic neuropathy (LHON) is rarely associated with multiple sclerosis-like features. We present a case of a 65-year-old African American woman with LHON masquerading as neuromyelitis optica (NMO). We highlight the features of the clinical examination and MRI that were suggestive of an alternative diagnosis and review the literature regarding LHON and multiple sclerosis. The diagnosis of LHON should be considered in all cases of acute or subacute bilateral optic neuropathy, including presumed seronegative NMO.
authors: Department of Ophthalmology, Washington University, St. Louis, Missouri, USA. mcclellandc@vision.wustl.edu
authors: Collin M
authors: CM
authors: McClelland
authors: Gregory P
authors: GP
authors: Van Stavern
authors: Alex C
authors: AC
authors: Tselis
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000235:genetics; D009471:Neuromyelitis Optica / Q000175:diagnosis* / Q000235:genetics; D029242:Optic Atrophy, Hereditary, Leber / Q000175:diagnosis* / Q000235:genetics*; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000235:genetics