title: [Discovering a new functional neurogenic zone: the vestibular nuclei of the brainstem].
abstract: The adult mammal brain is mostly considered as non-neurogenic, except in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus, where ongoing neurogenesis occurs. However, anti-neurogenic influences can be removed in pathological conditions or after specific injury. That is what happens in a model of unilateral vestibular neurectomy (UVN) that mimics human pathology in adult cats. We showed for the first time that a UVN promoted an intense reactive cell proliferation in the deafferented vestibular nuclei located in the brainstem. The new cells survived up to one month, differentiated into glial cells - microglia or astrocytes - or GABAergic neurons, so highlighting a GABAergic neurogenesis. Surprisingly, we further showed that post-UVN reactive cell proliferation contributed successfully to fine restoration of vestibular posturo-locomotor functions. In conclusion, these pioneering studies bring new pieces of a promising puzzle in both stem cell and vestibular therapy domains.
authors: UMR 6149, Neurosciences intégratives et adaptatives, pôle 3C : Comportement, cerveau, cognition, Centre de Saint-Charles, case B, 3, place Victor Hugo 13331 Marseille Cedex 3, France.
authors: Sophie
authors: S
authors: Dutheil
authors: Michel
authors: M
authors: Lacour
authors: Brahim
authors: B
authors: Tighilet
mesh_terms: D000367:Age Factors; D000818:Animals; D019771:Axotomy; D002415:Cats; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D004261:DNA Replication; D005968:Glutamate Decarboxylase / Q000032:analysis; D006801:Humans; D055495:Neurogenesis; D009474:Neurons / Q000737:chemistry / Q000166:cytology*; D020127:Recovery of Function; D012038:Regeneration / Q000502:physiology*; D015837:Vestibular Diseases / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D014725:Vestibular Nerve / Q000293:injuries / Q000502:physiology; D014726:Vestibular Nuclei / Q000166:cytology* / Q000293:injuries / Q000473:pathology; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000502:physiology
chemical_list: D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1