title: Pseuduvarines A and B, two new cytotoxic dioxoaporphine alkaloids from Pseuduvaria rugosa.
abstract: Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC₅₀, 0.9, 21.7, and >50.0 µM, respectively, 2: IC₅₀ >50.0, 15.7, and 12.4 µM, respectively).
authors: Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia. moritah@hoshi.ac.jp
authors: Hairin
authors: H
authors: Taha
authors: A Hamid A
authors: AH
authors: Hadi
authors: Noraziah
authors: N
authors: Nordin
authors: Ibrahim A
authors: IA
authors: Najmuldeen
authors: Khalit
authors: K
authors: Mohamad
authors: Osamu
authors: O
authors: Shirota
authors: Alfarius E
authors: AE
authors: Nugroho
authors: Wong Chin
authors: WC
authors: Piow
authors: Toshio
authors: T
authors: Kaneda
authors: Hiroshi
authors: H
authors: Morita
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001060:Aporphines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; C561819:pseuduvarine A; C561820:pseuduvarine B