title: Evaluation of the relationship between insulin resistance and recurrent pregnancy loss.
abstract: OBJECTIVE
  To investigate insulin resistance in patients with recurrent pregnancy loss (RPL).
  
  
  METHODS
  Single center, case-control, prospective study.
  
  
  METHODS
  The study was performed at the Obstetrics and Gynecology Clinic at the Dicle University Medical Faculty from May to October 2009. 64 study subjects who had RPL were compared to 64 controls. Both groups were compared with fasting glucose, fasting insulin, fasting glucose/fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) index values to assess insulin resistance.
  
  
  RESULTS
  No significant differences in age and BMI index were found between the study and control subjects (p > 0.005). The mean number of abortions was 3.04 in the study and 0.2 in the control group (p < 0.001). The mean fasting glucose value was 100.84 in the study group, and 89.67 in the control group (p < 0.001). Also, the mean fasting insulin value was 15.51 in the study group and 7.17 in the control group (p = 0.001). The mean glucose/ insulin ratio was 12.24 in the study group and 28.27 in the control group (p = 0.017), and the mean HOMA-IR value was 4.16 in the study group and 1.62 in the control group (p = 0.002).
  
  
  CONCLUSIONS
  Compared with the control group, patients with RPL were more likely to have insulin resistance.
authors: Dicle University School of Medicine, Department of Gynecology and Obstetrics, Diyaroakir, Turkey.
authors: Nazan
authors: N
authors: Celik
authors: Mehmet Siddik
authors: MS
authors: Evsen
authors: Muhammet Erdal
authors: ME
authors: Sak
authors: Ender
authors: E
authors: Soydinc
authors: Talip
authors: T
authors: Gul
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000503:physiopathology; D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D011044:Poland; D011247:Pregnancy; D011446:Prospective Studies; D012016:Reference Values; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin