title: Sublethal doses of surfactants induce premature senescence in normal human skin cells.
abstract: We evaluated the cytotoxicity of surfactants in human cells. Synthetic surfactants showed different cytotoxicity levels depending on their structures. The cytotoxicity of commercial washing products was determined mainly by the contents of surfactants. All of them induced premature senescence in normal cells, but not in tumor-derived or immortalized cells, under sublethal conditions. Residual surfactants might be a risk factor for skin aging.
authors: Department of Genome System Science, Yokohama City University, Kanagawa, Japan.
authors: Yoshimi
authors: Y
authors: Yamakami
authors: Kensuke
authors: K
authors: Miki
authors: Morio
authors: M
authors: Endoh
authors: Ryuzo
authors: R
authors: Yonekura
authors: Ryo
authors: R
authors: Ukekawa
authors: Yusuke
authors: Y
authors: Kobayashi
authors: Michihiko
authors: M
authors: Fujii
authors: Dai
authors: D
authors: Ayusawa
mesh_terms: D002460:Cell Line; D016922:Cellular Senescence / Q000187:drug effects*; D017364:Collagenases / Q000187:drug effects / Q000378:metabolism; D005353:Fibronectins / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000473:pathology*; D015595:Skin Aging / Q000187:drug effects*; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D005353:Fibronectins; D017395:Plasminogen Activator Inhibitor 1; D013501:Surface-Active Agents; D017364:Collagenases; C417249:collagenase 1