title: Infliximab therapy efficacy and persistence at a Canadian academic centre despite a change in access procedure.
abstract: Patients treated with infliximab at our centre through a special access programme (initiation group) had long-standing, treatment-resistant rheumatoid arthritis. The clinical experience for these patients may be different than that of patients initiating treatment after provincial government approval and cost coverage for all anti-tumour necrosis factor (anti-TNF) therapies became effective (contemporary group). We compared adverse events, drug survival and reasons for discontinuation in these two groups. A prospective cohort of patients treated with an anti-TNF therapy was assembled following the availability of infliximab in 2000. By protocol, patients are assessed for treatment response, discontinuation or switching of biologic agents and occurrence of adverse events. We report on 231 patients treated with infliximab therapy (680 patient-years). Both groups had similar drug survival (median 2.2 years) and rates of serious adverse events including infusion reactions (6.8 per 100 patient-years) and serious infections (3.4 per 100 patient-years). More patients in the initiation group discontinued infliximab for adverse events [39/139 (28%) vs. 15/92 (16%), p = 0.04] and developed drug-induced lupus [8/139 (6%) vs. 0%, p = 0.02]. Subsequent biologics were discontinued for the same reason as infliximab in only 12% (15/123) of cases. Patients treated with infliximab through a special access programme have comparable drug survival compared to a contemporary group, despite experiencing more adverse events. Only a minority of patients discontinuing infliximab due to the lack of effect or adverse events experience the same fate with subsequent anti-TNF agents.
authors: Division of Rheumatology, Department of Medicine, University of Calgary, Room 451 Heritage Medical Research Building, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada. ccbarnab@ucalgary.ca
authors: Cheryl
authors: C
authors: Barnabe
authors: Susan G
authors: SG
authors: Barr
authors: Liam
authors: L
authors: Martin
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002170:Canada; D005260:Female; D006801:Humans; D000069285:Infliximab; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D060735:Pharmacovigilance; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D000069285:Infliximab