title: Nitroalkylation--a redox sensitive signaling pathway.
abstract: Redox-sensitive posttranslational modification emerged as important signaling mechanisms. Besides other posttranslational modifications nitroalkylation by nitrated fatty acids mediate favorable anti-inflammatory effects. This review gives an overview of the generation and the reactivity of nitrated fatty acids. Additionally, it provides insights into the so far described pathways regulated by nitrated fatty acids. This article is part of a Special Issue entitled Regulation of Cellular Processes by S-nitrosylation.
authors: Cardiovascular Research Center, Department of Electrophysiology, University Heart Center, University of Hamburg, Hamburg, Germany.
authors: Anne C
authors: AC
authors: Geisler
authors: Tanja K
authors: TK
authors: Rudolph
mesh_terms: D000478:Alkylation; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism*; D051547:Heme Oxygenase-1 / Q000378:metabolism; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism*; D015538:Nitrosation / Q000502:physiology; D010084:Oxidation-Reduction; D047495:PPAR gamma / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D050794:STAT1 Transcription Factor / Q000037:antagonists & inhibitors; D015398:Signal Transduction
chemical_list: D005227:Fatty Acids; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495635:NFE2L2 protein, human; D009566:Nitrates; D047495:PPAR gamma; D050794:STAT1 Transcription Factor; D009569:Nitric Oxide; D051547:Heme Oxygenase-1; D020782:Matrix Metalloproteinases