title: Effects of additional treatment of sarpogrelate to aspirin therapy on platelet aggregation and plasma plasminogen activator inhibitor activity in patients with stable effort angina.
abstract: BACKGROUND
  Serotonin is secreted from platelets at sites of endothelial injury, where it promotes thrombogenic reactions. Serotonin is reported to be associated with not only coronary artery disease but also cardiac events.
  
  
  METHODS
  We studied 33 patients with stable effort angina (SEA) (11 patients with multivessel disease (MVD) and 22 patients with single vessel disease (SVD)) and 25 patients with chest pain syndrome (CPS). Sarpogrelate was administered to 22 of 33 patients with SEA in addition to aspirin therapy, and platelet aggregation, plasma serotonin concentration, and plasma plasminogen activator inhibitor (PAI) activity were measured before and 1 week after administration.
  
  
  CONCLUSIONS
  Serotonin level was higher in patients with MVD than in those with SVD (p<0.05) and in those with CPS (p<0.001). The formation of small-sized platelet aggregates was significantly higher in the high serotonin group than in the low serotonin group of SEA patients. The formation of large-sized platelet aggregates was significantly decreased by administration of sarpogrelate (P<0.05). The formation of small- or medium-sized aggregates was not significantly decreased. Plasma PAI activity decreased significantly (P<0.05) although the plasma serotonin concentration did not show significant change by administration of sarpogrelate. Plasma serotonin level is increased in relation to severity of coronary artery disease and plasma serotonin level is associated with increased platelet aggregation. Administration of sarpogrelate in addition to aspirin therapy reduces the increased platelet aggregation and PAI activity, and it may indicate that additional administration of sarpogrelate is useful for patients with SEA.
authors: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
authors: Ichiro
authors: I
authors: Kajiwara
authors: Hirofumi
authors: H
authors: Soejima
authors: Shinzo
authors: S
authors: Miyamoto
authors: Hisao
authors: H
authors: Ogawa
mesh_terms: D000328:Adult; D000368:Aged; D060050:Angina, Stable / Q000097:blood / Q000188:drug therapy*; D001241:Aspirin / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012701:Serotonin / Q000097:blood; D013386:Succinates / Q000627:therapeutic use*
chemical_list: D015849:Plasminogen Inactivators; D010975:Platelet Aggregation Inhibitors; D013386:Succinates; C064294:sarpogrelate; D012701:Serotonin; D001241:Aspirin