title: Effect of Helicobacter pylori infection on iron absorption in asymptomatic adults consuming wheat flour fortified with iron and zinc.
abstract: Helicobacter pylori infection could impair iron absorption from fortified products. The objective of the study was to determine the effect of H. pylori infection on iron absorption from asymptomatic adults consuming wheat flour fortified with iron and zinc. The (13)C urea breath test was used to assess H. pylori infection. Twenty-four H. pylori-positive and 26 H. pylori-negative volunteers completed the study. On day 1, the subjects were randomized to receive for breakfast bread fortified with either ferrous sulfate and zinc sulfate or ferrous fumarate and zinc oxide. Bread fortified with ferrous sulfate was labeled with (59)Fe as sulfate, and bread fortified with ferrous fumarate was labeled with (55)Fe as fumarate. On day 3, they received the other type of bread, with the respective tracers. On days 18-23, a proton pump inhibitor was administered to all subjects. On day 24, all subjects received bread fortified with ferrous fumarate and zinc oxide labeled with (55)Fe as fumarate. H. pylori prevalence was 77.6%. The geometric mean (±1 SD) of iron absorption was significantly higher for ferrous sulfate than fumarate (6.9 ± 2.9% vs. 0.5 ± 3.5%, p < 0.001). The H. pylori-negative subjects absorbed significantly more iron from bread fortified with either ferrous sulfate (10.5 ± 3.1% vs. 4.4 ± 2.2%, p < 0.001) or ferrous fumarate (0.6 ± 3.9% vs. 0.4 ± 3.1%, p < 0.001). Iron absorption was not significantly different between groups after administration of a proton pump inhibitor (0.3 ± 3.3% vs. 0.3 ± 2.7%, p = 0.11). H. pylori infection has a negative effect on iron absorption in asymptomatic adults consuming iron- and zinc-fortified wheat flour.
authors: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Avenida El Líbano, 5524, Macul, Santiago, Chile. dromana@inta.uchile.cl
authors: Daniel
authors: D
authors: López de Romaña
authors: Fernando
authors: F
authors: Pizarro
authors: Doricela
authors: D
authors: Diazgranados
authors: Armando
authors: A
authors: Barba
authors: Manuel
authors: M
authors: Olivares
authors: Oscar
authors: O
authors: Brunser
mesh_terms: D000328:Adult; D001939:Bread; D004032:Diet; D005260:Female; D005296:Ferrous Compounds / Q000494:pharmacology; D005433:Flour; D005527:Food, Fortified; D016481:Helicobacter Infections / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology*; D007501:Iron / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D007504:Iron Radioisotopes; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000494:pharmacology; D014908:Triticum / Q000737:chemistry*; D015032:Zinc / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D005296:Ferrous Compounds; D007504:Iron Radioisotopes; D054328:Proton Pump Inhibitors; C020748:ferrous sulfate; D007501:Iron; D015032:Zinc; C031621:ferrous fumarate