title: Reproductive toxicity of bisphenol A and cadmium in Potamopyrgus antipodarum and modulation of bisphenol A effects by different test temperature.
abstract: An OECD initiative for the development of mollusc-based toxicity tests for endocrine disrupters and other chemicals has recommended three test species with respective test designs for further standardisation. Preparing a subsequent pre-validation study we performed a reproduction test with Potamopyrgus antipodarum, determining the concentration range of the selected test substances, bisphenol A (BPA) and cadmium (Cd). At 16 °C, the recommended test temperature, the number of embryos in the brood pouch was increased by BPA and decreased by Cd (NOEC: 20 μg BPA/L and 1 μg Cd/L). Coinstantaneous BPA tests at 7 °C and 25 °C demonstrated a temperature dependency of the response, resulting in lower NOECs (5 μg/L respectively). As expected, reproduction in control groups significantly varied depending on temperature. Additional observations of the brood stock showed seasonal fluctuations in reproduction under constant laboratory conditions. The recommended temperature range and test conditions have to be further investigated.
authors: Department of Aquatic Ecotoxicology, Johann Wolfgang Goethe University Frankfurt am Main, Siesmayerstrasse 70, 60323 Frankfurt, Germany. A.Sieratowicz@bio.uni-frankfurt.de
authors: Agnes
authors: A
authors: Sieratowicz
authors: Daniela
authors: D
authors: Stange
authors: Ulrike
authors: U
authors: Schulte-Oehlmann
authors: Jörg
authors: J
authors: Oehlmann
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D002104:Cadmium / Q000633:toxicity*; D052244:Endocrine Disruptors / Q000633:toxicity; D005260:Female; D049851:Gastropoda / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010636:Phenols / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects; D013696:Temperature; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002104:Cadmium; D052244:Endocrine Disruptors; D010636:Phenols; D014874:Water Pollutants, Chemical; C006780:bisphenol A; D000098826:Bisphenol A Compounds