title: The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge.
abstract: It has recently been shown that polymorphism at the rhesus macaque TRIM5 locus can affect simian immunodeficiency virus (SIV) replication. Here we show that TRIM5 alleles can also affect acquisition of SIVsmE660. Animals coexpressing the TRIM5(TFP) and TRIM5(CypA) alleles took significantly longer to become infected with SIVsmE660, but not SIVmac239, after repeated limiting-dose intrarectal challenge than did animals expressing other TRIM5 allele combinations. Our results indicate that the TRIM5 alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses.
authors: AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, WI 53711, USA. mrreynol@wisc.edu
authors: Matthew R
authors: MR
authors: Reynolds
authors: Jonah B
authors: JB
authors: Sacha
authors: Andrea M
authors: AM
authors: Weiler
authors: Gretta J
authors: GJ
authors: Borchardt
authors: Chrystal E
authors: CE
authors: Glidden
authors: Neil C
authors: NC
authors: Sheppard
authors: Francesca A
authors: FA
authors: Norante
authors: Philip A
authors: PA
authors: Castrovinci
authors: Jacqueline J
authors: JJ
authors: Harris
authors: Henry T
authors: HT
authors: Robertson
authors: Thomas C
authors: TC
authors: Friedrich
authors: Adrian B
authors: AB
authors: McDermott
authors: Nancy A
authors: NA
authors: Wilson
authors: David B
authors: DB
authors: Allison
authors: Wayne C
authors: WC
authors: Koff
authors: Welkin E
authors: WE
authors: Johnson
authors: David I
authors: DI
authors: Watkins
mesh_terms: D000818:Animals; D005838:Genotype; D006801:Humans; D007113:Immunity, Innate; D008253:Macaca mulatta; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D012007:Rectum / Q000821:virology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000635:transmission / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000472:pathogenicity*; D044767:Ubiquitin-Protein Ligases
chemical_list: D011506:Proteins; C482587:TRIM5(alpha) protein, rhesus monkey; D044767:Ubiquitin-Protein Ligases