title: CR1 genotype is associated with entorhinal cortex volume in young healthy adults.
abstract: Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively). We assessed structural differences in 2 core structures of Alzheimer pathology, entorhinal cortex and hippocampus, by voxel-based morphometry using high-resolution magnetic resonance imaging (MRI) data. For CLU and PICALM no significant genotype-related differences in local gray matter volume were found. CR1 risk allele (A) carriers showed smaller local gray matter volume in the entorhinal cortex, as confirmed in both cohorts. This association, apparent in young healthy adults, might mediate susceptibility for Alzheimer's disease later in life.
authors: Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands.
authors: Janita
authors: J
authors: Bralten
authors: Barbara
authors: B
authors: Franke
authors: Alejandro
authors: A
authors: Arias-Vásquez
authors: Angelien
authors: A
authors: Heister
authors: Han G
authors: HG
authors: Brunner
authors: Guillén
authors: G
authors: Fernández
authors: Mark
authors: M
authors: Rijpkema
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D018728:Entorhinal Cortex / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size / Q000235:genetics; D017463:Receptors, Complement 3b / Q000235:genetics*
chemical_list: C509991:CR1 protein, human; D017463:Receptors, Complement 3b