title: Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb.
abstract: We hypothesized that neonatal xenoestrogen exposure affects the ovarian follicular dynamics in lambs. Female lambs were exposed from postnatal day (PND) 1-14 to low doses of diethylstilbestrol (DES) or bisphenol A (BPA). At PND 30, the follicular dynamics and ovarian biomarkers (ERα, ERβ, AR, Ki67, p27) were evaluated. Lambs exposed to DES or BPA showed a decline in the stock of primordial follicles with stimulation of follicular development. BPA reduced ovarian weight and increased the number of multioocyte follicles. BPA promoted proliferation of granulosa/theca cells in antral follicles, and increased both the number of antral atretic follicles and p27 expression. Neonatal exposure to BPA or DES reduced the primordial follicle pool by stimulating their initial recruitment and subsequent follicle development until antral stage. In prepubertal lambs, the accelerated folliculogenesis resulted in increased incidence of atretic follicles. These alterations may affect the ovarian function in the adult.
authors: School of Agricultural Sciences, Universidad Nacional de Lomas de Zamora, Buenos Aires, Argentina.
authors: Oscar E
authors: OE
authors: Rivera
authors: Jorgelina
authors: J
authors: Varayoud
authors: Horacio A
authors: HA
authors: Rodríguez
authors: Mónica
authors: M
authors: Muñoz-de-Toro
authors: Enrique H
authors: EH
authors: Luque
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001559:Benzhydryl Compounds; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism; D004054:Diethylstilbestrol / Q000633:toxicity*; D047628:Estrogen Receptor alpha / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D005260:Female; D019394:Ki-67 Antigen / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D006080:Ovarian Follicle / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000187:drug effects / Q000254:growth & development; D010636:Phenols / Q000633:toxicity*; D011944:Receptors, Androgen / Q000378:metabolism; D034561:Sheep, Domestic; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D050760:Cyclin-Dependent Kinase Inhibitor p27; D004054:Diethylstilbestrol; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004968:Estrogens, Non-Steroidal; D019394:Ki-67 Antigen; D010636:Phenols; D011944:Receptors, Androgen; C006780:bisphenol A; D000098826:Bisphenol A Compounds