title: Synthesis of H-Labeled Tetrabenazine (TBZ).
abstract: Tetrabenazine (TBZ) (1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolin-2-one), a vesicular monamine transporter 2 inhibitor, was prepared as a tritium-labeled compound with high specific activity and radiochemical purity. Catalytic hydrogenation of a precursor with the terminal double bond was used to introduce the tritium. This method provides tritium-labeled TBZ with high specific activity and radiochemical purity, which allow the further investigation of a TBZ in the neurological field.
authors: Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
authors: Sung-Whi
authors: SW
authors: Rhee
authors: Kenneth J
authors: KJ
authors: Ryan
authors: Mary J
authors: MJ
authors: Tanga