title: Trends in the incidence of oral cavity and oropharyngeal cancers in Spain.
abstract: BACKGROUND
  The purpose of this study was to analyze and compare incidence trends of oral cavity and oropharyngeal cancers, using data from population-based Spanish cancer registries.
  
  
  METHODS
  Adjusted rates were calculated using the standard world population, and incidence trends were analyzed for individual and pooled registries using joinpoint regression.
  
  
  RESULTS
  Analysis of 7 pooled registries revealed a statistically significant reduction in the incidence of oral cavity cancer in men (annual percent change [APC] = -3.1) and a nonsignificant decrease in women (APC = -4.5) over the period from 1991 to 2001. For oropharyngeal cancer, the trend was for a statistically significant increase in men in 4 registries.
  
  
  CONCLUSIONS
  There is growing evidence that the incidence of oral cavity cancer is in decline, while the incidence of oropharyngeal cancer has been increasing over the past 3 decades, especially in developed countries, and this study reinforces such evidence.
authors: Departamento de Microbiología, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, España.
authors: Dyego Leandro Bezerra
authors: DL
authors: de Souza
authors: Marianna
authors: M
authors: de Camargo Cancela
authors: María Milagros Bernal
authors: MM
authors: Pérez
authors: Maria-Paula
authors: MP
authors: Curado
mesh_terms: D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009062:Mouth Neoplasms / Q000453:epidemiology*; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology*; D012042:Registries; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology