title: Synthesis, DNA binding and cleavage activities of copper (II) thiocyanate complex with 4-(N,N-dimethylamino)pyridine and N,N-dimethylformamide.
abstract: Two novel copper(II) thiocyanate complexes with 4-(N,N-dimethylamino) pyridine and N,N-dimethylformamide (1) and with 4-(N,N-dimethylamino) pyridine (2) have been synthesized and characterized. The crystal and molecular structures of complexes 1 and 2 were determined by single-crystal X-ray diffraction. Antioxidative activity tests in vitro showed that complex 1 has significant antioxidative activity against hydroxyl free radicals from the Fenton reaction and also oxygen free radicals, which is better than standard antioxidants like vitamin C and mannitol. The interaction of complex 1 with calf thymus DNA was investigated by spectroscopic, cyclic voltammetry, and viscosity measurements. Results suggest that complex 1 can bind to DNA via partial intercalation mode. Moreover, complex 1 has been found to cleavage of plasmid DNA pBR322.
authors: State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Tian-shui Road 222, Lanzhou 730000, PR China.
authors: Feng-juan
authors: FJ
authors: Chen
authors: Min
authors: M
authors: Xu
authors: Pin-xian
authors: PX
authors: Xi
authors: Hong-yang
authors: HY
authors: Liu
authors: Zheng-zhi
authors: ZZ
authors: Zeng
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000096:biosynthesis / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects*; D004126:Dimethylformamide; D005559:Formamides / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013861:Thiocyanates / Q000737:chemistry / Q000378:metabolism
chemical_list: D056831:Coordination Complexes; D005559:Formamides; D009942:Organometallic Compounds; D011725:Pyridines; D013861:Thiocyanates; D003300:Copper; D004126:Dimethylformamide; D004247:DNA