title: Oxidative stress, inflamm-aging and immunosenescence.
abstract: Immunosenescence is characterized by a decreased ability of the immune system to respond to foreign antigens, as well as a decreased ability to maintain tolerance to self-antigens. This results in an increased susceptibility to infection and cancer and reduced responses to vaccination [1-5]. The mechanisms underlying immunosenescence comprise a series of cellular and molecular events involving alteration of several biochemical pathways and different cellular populations, and for the most part our understanding of these molecular mechanisms is still fragmentary. In this review we will focus on the process of senescence associated with oxidative stress, in particular how protein oxidation alters the functionality of immune cells and how oxidative stress contributes to a chronic inflammatory process often referred as inflamm-aging.
authors: Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors: Elvira S
authors: ES
authors: Cannizzo
authors: Cristina C
authors: CC
authors: Clement
authors: Ranjit
authors: R
authors: Sahu
authors: Carlo
authors: C
authors: Follo
authors: Laura
authors: L
authors: Santambrogio
mesh_terms: D000375:Aging / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D016922:Cellular Senescence / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000378:metabolism / Q000502:physiology*; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D008954:Models, Biological; D015538:Nitrosation / Q000502:physiology; D018384:Oxidative Stress / Q000276:immunology / Q000502:physiology*; D050050:Protein Carbonylation / Q000502:physiology; D011499:Protein Processing, Post-Translational