title: Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis.
abstract: The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.
authors: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
authors: Jing
authors: J
authors: Xu
authors: Ping
authors: P
authors: Guo
authors: Cuizhou
authors: C
authors: Liu
authors: Zhanping
authors: Z
authors: Sun
authors: Liping
authors: L
authors: Gui
authors: Yuanqiang
authors: Y
authors: Guo
authors: Tohru
authors: T
authors: Yamakuni
authors: Yasushi
authors: Y
authors: Ohizumi
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification*; D031410:Fritillaria / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D009447:Neuroblastoma; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000302:isolation & purification*; D018517:Plant Roots / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D045786:Diterpenes, Kaurane; D018696:Neuroprotective Agents