title: Antihyperglycaemic and hypolipidaemic effects of the methanolic extract of Caralluma tuberculata in streptozotocin-induced diabetic rats.
abstract: The antihyperglycaemic and hypolipidaemic effects of the methanolic extract of Caralluma tuberculata were investigated in streptozotocin (STZ)-induced diabetic rats. The antihyperglycaemic activity was assessed by the reduction in fasting blood glucose (54% at 4th week) and the peak of blood glucose at 120?min of an oral glucose tolerance test in diabetic rats. Further, the tested extract also increased plasma insulin by 206.8%. The hypolipidaemic action of the extract was evident by the significant decrease in the levels of total cholesterol, triglycerides and LDL-cholesterol by 41.5%, 36.7% and 49.1%, respectively, compared to diabetic rat values. Interestingly, the extract increased the cardio-protective lipid HDL-cholesterol by 147.97% as compared to diabetic rat value. The present data suggests that the methanolic extract of C. tuberculata has both antihyperglycaemic and hypolipidaemic effects in STZ-induced diabetic rats that may need further studies to be used in the management of diabetes and associated hyperlipedaemia.
authors: Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. abdelsattar@yahoo.com
authors: Essam
authors: E
authors: Abdel-Sattar
authors: Fathalla M
authors: FM
authors: Harraz
authors: Salah A
authors: SA
authors: Ghareib
authors: Ahmed A
authors: AA
authors: Elberry
authors: Salah
authors: S
authors: Gabr
authors: Mansour I
authors: MI
authors: Suliaman
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000032:analysis / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000032:analysis / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D000432:Methanol; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D000432:Methanol