title: A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway.
abstract: Receptor activator of nuclear factor-kappa B ligand (RANKL) is a member of tumor necrosis factor (TNF) superfamily that plays a key role in the regulation of differentiation, activation and survival of osteoclasts and also in tumor cell migration and bone metastasis. Osteoclast activation induced by RANKL regulates hematopoietic stem cell mobilization as part of homeostasis and host defense mechanisms thereby linking regulation of hematopoiesis with bone remodeling. Binding of RANKL to its receptor, Receptor activator of nuclear factor-kappa B (RANK) activates molecules such as NF-kappa B, mitogen activated protein kinase (MAPK), nuclear factor of activated T cells (NFAT) and phosphatidyl 3-kinase (PI3K). Although the molecular and cellular roles of these molecules have been reported previously, a systematic cataloging of the molecular events induced by RANKL/RANK interaction has not been attempted. Here, we present a comprehensive reaction map of the RANKL/RANK-signaling pathway based on an extensive manual curation of the published literature. We hope that the curated RANKL/RANK-signaling pathway model would enable new biomedical discoveries, which can provide novel insights into disease processes and development of novel therapeutic interventions.
authors: Institute of Bioinformatics, International Technology Park, Bangalore 560066, India.
authors: Rajesh
authors: R
authors: Raju
authors: Lavanya
authors: L
authors: Balakrishnan
authors: Vishalakshi
authors: V
authors: Nanjappa
authors: Mitali
authors: M
authors: Bhattacharjee
authors: Derese
authors: D
authors: Getnet
authors: Babylakshmi
authors: B
authors: Muthusamy
authors: Joji
authors: J
authors: Kurian Thomas
authors: Jyoti
authors: J
authors: Sharma
authors: B Abdul
authors: BA
authors: Rahiman
authors: H C
authors: HC
authors: Harsha
authors: Subramanian
authors: S
authors: Shankar
authors: T S Keshava
authors: TS
authors: Prasad
authors: S Sujatha
authors: SS
authors: Mohan
authors: Gary D
authors: GD
authors: Bader
authors: Mohan R
authors: MR
authors: Wani
authors: Akhilesh
authors: A
authors: Pandey
mesh_terms: D003628:Database Management Systems; D016208:Databases, Factual; D006801:Humans; D053245:RANK Ligand / Q000235:genetics / Q000378:metabolism*; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; C505688:TNFSF11 protein, human