title: Effect of CBT on Depressive Symptoms in Methadone Maintenance Patients Undergoing Treatment for Hepatitis C.
abstract: To examine the efficacy of a cognitive-behavioral intervention (CBT) to prevent depression among methadone maintenance patients undergoing antiviral treatment for hepatitis C (HCV), 29 patients beginning HCV treatment were randomized to CBT or standard care (SC). Study participants did not meet criteria for major depressive disorder at the time of study recruitment. CBT did not result in less depression-related antiviral treatment failure, better adherence to antiviral treatment, or better HCV RNA outcomes. There were no significant treatment group differences on depressive symptoms over time. The CBT group did display a greater and more consistent decline in both BDI-II and HAM-D scores over time (d=.85 on the BDI-II; d=.72 on the HAM-D).
authors: The Warren Alpert Medical School of Brown University, USA.
authors: Susan E
authors: SE
authors: Ramsey
authors: Patricia A
authors: PA
authors: Engler
authors: Michael D
authors: MD
authors: Stein
authors: Richard A
authors: RA
authors: Brown
authors: Patricia
authors: P
authors: Cioe
authors: Christopher W
authors: CW
authors: Kahler
authors: Kittichai
authors: K
authors: Promrat
authors: Jennifer
authors: J
authors: Rose
authors: Jennifer
authors: J
authors: Anthony
authors: David A
authors: DA
authors: Solomon