title: Cisplatin ototoxicity affecting cochlear implant benefit.
abstract: OBJECTIVE
  Report a case of loss of cochlear implant benefit after cisplatin therapy to treat osteosarcoma. Examine the implications for the loci of cisplatin-associated cochleotoxicity.
  
  
  METHODS
  Retrospective case review.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Single case study.
  
  
  METHODS
  None.
  
  
  METHODS
  Cochlear implant programming levels.
  
  
  RESULTS
  Increase in cochlear implant programming T- and C-levels after cisplatin therapy.
  
  
  CONCLUSIONS
  Cisplatin therapy likely affects spiral ganglion cells. It seems that auditory cells other than outer hair cells in the organ of Corti are affected by cisplatin because the hearing sensitivity of this patient with nonfunctioning outer hair cells declined after receiving chemotherapy. Implications of these findings are discussed.
authors: DeVault Otologic Research Laboratory, Department of Otolaryngology-Head and Neck Surgery, Indiana, USA. michharr@iupui.edu
authors: Michael S
authors: MS
authors: Harris
authors: Jaimie L
authors: JL
authors: Gilbert
authors: Kelly A
authors: KA
authors: Lormore
authors: Swapna A
authors: SA
authors: Musunuru
authors: Michael H
authors: MH
authors: Fritsch
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D019929:Cochlear Implantation; D003054:Cochlear Implants; D005266:Femoral Neoplasms / Q000188:drug therapy*; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy*; D013067:Speech Perception / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin