title: CNS regulation of plasma cholesterol.
abstract: The incidence of disorders related to the control of energy homeostasis, such as hypertension, diabetes, obesity, and dyslipidemia, has dramatically increased worldwide in the last decades. The central nervous system (CNS) plays a critical role regulating the energy balance, therefore there has been increasing interest in understanding the mechanisms whereby the brain controls peripheral metabolism, in order to develop new potential therapies to treat those disorders. While the involvement of the CNS in development of hypertension, obesity, and diabetes has been thoroughly investigated, less is known about the specific role of the brain in the control of circulating lipids. Here we summarize the evidence linking CNS disorders with dyslipidemia, as well as the central mechanisms that directly influence plasma cholesterol.
authors: Department of Internal Medicine, Metabolic Diseases Institute & Cincinnati Diabetes and Obesity Centre, Cincinnati, OH 45237, USA.
authors: Diego
authors: D
authors: Perez-Tilve
authors: W Sean
authors: WS
authors: Davidson
authors: Matthias
authors: M
authors: Tschöp
authors: Susanna M
authors: SM
authors: Hofmann
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000517:prevention & control; D002490:Central Nervous System / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009490:Neurosecretory Systems / Q000378:metabolism*
chemical_list: D007328:Insulin; D020738:Leptin; D002784:Cholesterol