title: Shuttle-mediated drug delivery to the brain.
abstract: Advances in the field of shuttle-mediated drug delivery have been made in the last decade; however, the treatment of brain disorders still remains a great challenge because of the presence of the blood-brain barrier (BBB), a structure that limits the access of drugs to their site of action in the central nervous system. Several strategies have been proposed to enhance the transport of drugs across the BBB. In this Review, we focus on the vector-mediated approach, in which a drug is coupled to a molecule (shuttle) that has the ability to cross the BBB and deliver the drug to the brain.
authors: Institute for Research in Biomedicine, Barcelona Science Park, Spain.
authors: Morteza
authors: M
authors: Malakoutikhah
authors: Meritxell
authors: M
authors: Teixidó
authors: Ernest
authors: E
authors: Giralt
mesh_terms: D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry*; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D015215:Zidovudine / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D010455:Peptides; D015215:Zidovudine