title: Exaggeration of wrinkles after botulinum toxin injection for forehead horizontal lines.
abstract: There have been no long-term complications or life-threatening adverse effects related to botulinum toxin treatment for any cosmetic indications. Nevertheless, there are well-known, mild side effects of botulinum toxin treatment on the upper face, though most of them are self limited with time. However, excluding brow ptosis, reports about site specific side effects are few and anecdotal. We experienced cases of exaggeration of wrinkles after botulinum toxin injection for forehead horizontal lines, and report them here. In our cases, new appearance of a noticeable glabellar protrusion following botulinum toxin injection on the forehead was observed in 2 patients. Also, a new deep wrinkle on one side of the forehead just above the eyebrow appeared in another 2 patients. The exaggerated wrinkles nearly disappeared without treatment by week 4 in all subjects. These exaggerations of wrinkles may be caused by hyperactivity and overcompensation of untreated muscles. With the increasing availability of diverse botulinum toxin for cosmetic purposes, physicians and patients should be aware of this temporary change after therapeutic injections. We recommend explaining this possible effect prior to injection, for better understanding of treatment for cosmetic indications.
authors: Department of Dermatology, Asan Medical Center, Seoul, Korea.
authors: Seong Min
authors: SM
authors: Kang
authors: Ashley
authors: A
authors: Feneran
authors: Jae Kyung
authors: JK
authors: Kim
authors: Ounjae
authors: O
authors: Park
authors: Jeong Eun
authors: JE
authors: Kim
authors: Chong Hyun
authors: CH
authors: Won
authors: Sungeun
authors: S
authors: Chang
authors: Mi Woo
authors: MW
authors: Lee
authors: Jee Ho
authors: JH
authors: Choi
authors: Kee Chan
authors: KC
authors: Moon
authors: Choon Shik
authors: CS
authors: Youn
authors: Soyun
authors: S
authors: Cho
authors: Sang Hyub
authors: SH
authors: Lee