title: Comparison of permanent hair loss in children with standard risk PNETS of the posterior fossa following radiotherapy alone or chemotherapy and radiotherapy after surgical resection.
abstract: Hair loss was compared between surgery followed by craniospinal radiotherapy (CSRT) or chemotherapy then CSRT (C-CSRT) for medulloblastoma. The proportion of patients exhibiting hair loss in the cranial field was 70.0% (C-CSRT) versus 30.0% (CSRT) (95% CI: 14.7% to 58.9%; P = 0.002). The C-CSRT group also experienced more virtual/complete hair loss over the posterior fossa boost. Age was a significant contributor to hair loss in the cranial field. Persistent significant hair loss is an under-reported late effect of treatment that could influence quality of survival and should be considered in future trial design.
authors: Royal Marsden Hospital, Sutton, Surrey, UK.
authors: Susanne
authors: S
authors: Rogers
authors: Paul
authors: P
authors: Donachie
authors: Elaine
authors: E
authors: Sugden
authors: Geoffrey
authors: G
authors: Sharpe
authors: Martin
authors: M
authors: English
authors: Kath
authors: K
authors: Robinson
authors: Frank
authors: F
authors: Saran
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000505:Alopecia / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015192:Infratentorial Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D016015:Logistic Models; D008297:Male; D018242:Neuroectodermal Tumors, Primitive / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D012307:Risk Factors