title: Asymmetric synthesis of bioactive hydrodibenzofuran alkaloids: (-)-lycoramine, (-)-galanthamine, and (+)-lunarine.
abstract: Divergent route: a direct C-C bond-forming approach to the key aryl-substituted all-carbon quaternary stereogenic center present in bioactive hydrodibenzofuran alkaloids has been discovered. This approach involves an unprecedented organocatalytic enantioselective Michael addition of α-cyanoketones with acrylates and was used in a novel and divergent synthetic strategy for the title compounds in asymmetric fashion.
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Tianshui Nanlu, China.
authors: Peng
authors: P
authors: Chen
authors: Xu
authors: X
authors: Bao
authors: Le-Fen
authors: LF
authors: Zhang
authors: Ming
authors: M
authors: Ding
authors: Xiao-Jie
authors: XJ
authors: Han
authors: Jing
authors: J
authors: Li
authors: Guo-Biao
authors: GB
authors: Zhang
authors: Yong-Qiang
authors: YQ
authors: Tu
authors: Chun-An
authors: CA
authors: Fan
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001572:Benzofurans / Q000737:chemistry*; D019607:Brassicaceae / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D005702:Galantamine / Q000138:chemical synthesis* / Q000737:chemistry; D019668:Liliaceae / Q000737:chemistry; D013095:Spermidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D047151:Amaryllidaceae Alkaloids; D001572:Benzofurans; C511148:lunarine; D005702:Galantamine; D002244:Carbon; C105430:benzofuran; C500482:lycoramine; D013095:Spermidine