title: The assessment of vascular function during dietary intervention trials in human subjects.
abstract: The potential to reduce cardiovascular morbidity through dietary modification remains an area of intense clinical and scientific interest. Any putatively beneficial intervention should be tested within a randomised controlled trial which records appropriate endpoints, ideally incident CVD and death. However, the large sample sizes required for these endpoints and associated high costs mean that the majority of dietary intervention research is conducted over short periods among either healthy volunteers or those at only slightly increased risk, with investigators using a diverse range of surrogate measures to estimate arterial health in these studies. The present review identifies commonly employed techniques, discusses the relative merits of each and highlights emerging approaches.
authors: Centre for Public Health, Queen's University Belfast, Belfast, UK.
authors: Damian O
authors: DO
authors: McCall
authors: Michelle C
authors: MC
authors: McKinley
authors: Rebecca
authors: R
authors: Noad
authors: Pascal P
authors: PP
authors: McKeown
authors: David R
authors: DR
authors: McCance
authors: Ian S
authors: IS
authors: Young
authors: Jayne V
authors: JV
authors: Woodside
mesh_terms: D001158:Arteries / Q000502:physiology* / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis; D002318:Cardiovascular Diseases / Q000178:diet therapy* / Q000503:physiopathology / Q000517:prevention & control; D004548:Elasticity; D004730:Endothelium, Vascular / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D017063:Outcome Assessment, Health Care; D011674:Pulse; D012107:Research Design; D014664:Vasodilation
chemical_list: D015415:Biomarkers