title: Dietary free glutamate prevents diarrhoea during intra-gastric tube feeding in a rat model.
abstract: Recent studies indicate that l-glutamate (l-Glu), abundant in many foods, is a stimulator of gastric vagal afferent nerves. The aim of the present study was to examine the possibility that l-Glu supplementation of a protein-rich liquid diet may prevent the incidence of diarrhoea during repetitive intra-gastric tube feeding. The gastric vagal afferent nerve recording of rats indicated that intra-gastric administration of a protein-rich liquid diet supplemented with 0·5 % monosodium glutamate enhanced the basal afferent activities seen with the protein-rich diet alone. The examination of the faeces showed that the addition of monosodium glutamate to the liquid diet significantly prevented the incidence of diarrhoea induced by repetitive gastric feeding. In conclusion, supplementation of an enteral liquid diet with free l-Glu may ameliorate diarrhoea during intra-gastric tube feeding by sending visceral glutamate information from the stomach to the brain.
authors: Institute for Innovation, Ajinomoto Company, Inc., 210-8681 Kanagawa, Japan.
authors: Shinji
authors: S
authors: Somekawa
authors: Naoki
authors: N
authors: Hayashi
authors: Akira
authors: A
authors: Niijima
authors: Hisayuki
authors: H
authors: Uneyama
authors: Kunio
authors: K
authors: Torii
mesh_terms: D000344:Afferent Pathways; D000818:Animals; D003967:Diarrhea / Q000209:etiology / Q000517:prevention & control*; D004044:Dietary Proteins / Q000008:administration & dosage; D004195:Disease Models, Animal; D004750:Enteral Nutrition / Q000009:adverse effects*; D005243:Feces / Q000737:chemistry; D005526:Food, Formulated / Q000032:analysis; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D012970:Sodium Glutamate / Q000008:administration & dosage / Q000627:therapeutic use*; D013270:Stomach; D013997:Time Factors; D014630:Vagus Nerve / Q000503:physiopathology
chemical_list: D004044:Dietary Proteins; D012970:Sodium Glutamate