title: Inhibition of restriction enzymes EcoRI, BamHI and HindIII by phenethylphenylphthalimides derived from thalidomide.
abstract: We discovered inhibitors of the restriction enzymes EcoRI, BamHI and HindIII by screening our library of compounds with a phenethylphenylphthalimide skeleton, based on α-glucosidase inhibitors and liver X receptor antagonists derived from thalidomide. Structural development afforded the potent restriction enzyme inhibitors 25 and 26.
authors: Institute of Molecular & Cellular Biosciences, The University of Tokyo, Japan.
authors: Kazunori
authors: K
authors: Motoshima
authors: Minoru
authors: M
authors: Ishikawa
authors: Yuichi
authors: Y
authors: Hashimoto
authors: Kazuyuki
authors: K
authors: Sugita
mesh_terms: D015245:Deoxyribonuclease BamHI / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015246:Deoxyribonuclease EcoRI / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015247:Deoxyribonuclease HindIII / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D054833:Isoindoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors / Q000037:antagonists & inhibitors / Q000378:metabolism; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013792:Thalidomide / Q000737:chemistry*; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: C561817:4,5,6,7-tetrachloro-2-(3-(2-(3,4,5-trihydroxyphenyl)ethyl)phenyl)isoindole-1,3-dione; C561818:4,5,6,7-tetrachloro-2-(4-(2-(3,4,5-trihydroxyphenyl)ethyl)phenyl)isoindole-1,3-dione; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D054833:Isoindoles; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D010797:Phthalimides; D013792:Thalidomide; D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI; D015247:Deoxyribonuclease HindIII; D000520:alpha-Glucosidases