title: Oestradiol regulates β-catenin-mediated transcription in neurones.
abstract: Oestradiol acts in the brain by multiple mechanisms, including the regulation of transcriptional activity through classical oestrogen receptors, α and β, and by the activation of membrane/cytoplasm-initiated signalling cascades. In neuroblastoma cells, primary neurones in culture and in the brain in vivo, oestradiol activates the phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 signalling pathway by a mechanism involving oestrogen receptor α. Through this pathway, oestradiol regulates the stability of β-catenin, induces the translocation of β-catenin to the cell nucleus and regulates β-catenin-mediated transcription through the T cell factor/DNA complex. Genomic analyses in neuroblastoma cells have revealed that the set of genes regulated by oestradiol through β-catenin is not identical to that regulated by the Wnt signalling pathway, revealing a new mechanism for oestradiol signalling in neurones.
authors: Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.
authors: F
authors: F
authors: Wandosell
authors: O
authors: O
authors: Varea
authors: M A
authors: MA
authors: Arevalo
authors: L M
authors: LM
authors: Garcia-Segura
mesh_terms: D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D014158:Transcription, Genetic / Q000187:drug effects*; D060449:Wnt Signaling Pathway / Q000187:drug effects / Q000235:genetics; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051176:beta Catenin; D004958:Estradiol