title: Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template.
abstract: Synthetic analogues of the marine-derived class of natural products phloeodictines have been prepared and exhibited potent in vitro fungicidal activities against a broad array of fungal pathogens including drug resistant strains. The 6-hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium structural moiety with a C12 to C16 aliphatic side chain at C-6 has been shown to be the antifungal pharmacophore and may serve as a new antifungal template for further lead optimization.
authors: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Mississippi 38677.
authors: Xing-Cong
authors: XC
authors: Li
authors: K Suresh
authors: KS
authors: Babu
authors: Melissa R
authors: MR
authors: Jacob
authors: Shabana I
authors: SI
authors: Khan
authors: Ameeta K
authors: AK
authors: Agarwal
authors: Alice M
authors: AM
authors: Clark