title: Cladribine as a therapeutic option in multiple sclerosis.
abstract: There is an unmet need for more potent and convenient drugs in the treatment of patients diagnosed with multiple sclerosis (MS). Among five currently investigated oral drugs with an ongoing or completed phase III program, promising efficacy data for oral cladribine have recently been published. However, benefits need to be weighed against potential risks to define the role of this compound within current treatment regimens. Here we review present data on efficacy of oral cladribine and discuss known and anticipated risks of this drug.
authors: Department of Neurology, Heinrich-Heine-University Düsseldorf, Germany.
authors: Clemens
authors: C
authors: Warnke
authors: Verena I
authors: VI
authors: Leussink
authors: Norbert
authors: N
authors: Goebels
authors: Orhan
authors: O
authors: Aktas
authors: Alexey
authors: A
authors: Boyko
authors: Bernd C
authors: BC
authors: Kieseier
authors: Hans-Peter
authors: HP
authors: Hartung
mesh_terms: D017338:Cladribine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009103:Multiple Sclerosis / Q000188:drug therapy*
chemical_list: D007166:Immunosuppressive Agents; D017338:Cladribine