title: How to cluster gene expression dynamics in response to environmental signals.
abstract: Organisms usually cope with change in the environment by altering the dynamic trajectory of gene expression to adjust the complement of active proteins. The identification of particular sets of genes whose expression is adaptive in response to environmental changes helps to understand the mechanistic base of gene-environment interactions essential for organismic development. We describe a computational framework for clustering the dynamics of gene expression in distinct environments through Gaussian mixture fitting to the expression data measured at a set of discrete time points. We outline a number of quantitative testable hypotheses about the patterns of dynamic gene expression in changing environments and gene-environment interactions causing developmental differentiation. The future directions of gene clustering in terms of incorporations of the latest biological discoveries and statistical innovations are discussed. We provide a set of computational tools that are applicable to modeling and analysis of dynamic gene expression data measured in multiple environments.
authors: Department of Statistics, Pennsylvania State University, Hershey, PA 17033, USA.
authors: Yaqun
authors: Y
authors: Wang
authors: Meng
authors: M
authors: Xu
authors: Zhong
authors: Z
authors: Wang
authors: Ming
authors: M
authors: Tao
authors: Junjia
authors: J
authors: Zhu
authors: Li
authors: L
authors: Wang
authors: Runze
authors: R
authors: Li
authors: Scott A
authors: SA
authors: Berceli
authors: Rongling
authors: R
authors: Wu
mesh_terms: D000465:Algorithms; D002454:Cell Differentiation; D016000:Cluster Analysis; D003198:Computer Simulation; D030541:Databases, Genetic; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000379:methods; D059647:Gene-Environment Interaction