title: Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.
abstract: It has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of β-amyloid aggregation (Aβ), by scavenging oxidants and exerting anti-inflammatory activities. In this paper, we demonstrate that resveratrol is cytoprotective in human neuroblastoma cells exposed to Aβ and or to Aβ-metal complex. Our findings suggest that resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties.
authors: Centro Nazionale delle Ricerche, Istituto Tecnologie Biomediche, Metalloproteins Unit, Department of Biology, University of Padova, Padova, Italy.
authors: Alberto
authors: A
authors: Granzotto
authors: Paolo
authors: P
authors: Zatta
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000633:toxicity*; D006801:Humans; D009447:Neuroblastoma / Q000378:metabolism; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D056831:Coordination Complexes; D013267:Stilbenes; D000077185:Resveratrol