title: An infectious disease of ducks caused by a newly emerged Tembusu virus strain in mainland China.
abstract: During investigations into an outbreak of egg production decline, retarded growth, and even death among ducks in Southeast China, a novel Tembusu virus strain named Tembusu virus Fengxian 2010 (FX2010) was isolated. This virus replicated in embryonated chicken eggs and caused embryo death. In cross-neutralization tests, antiserum to the partial E protein of Tembusu virus Mm1775 strain neutralized FX2010, whereas antiserum to Japanese encephalitis virus did not. FX2010 is an enveloped RNA virus of approximately 45-50 nm in diameter. Sequence analysis of its E and NS5 genes showed that both genes share up to 99.6% nucleotide sequence identity with Baiyangdian virus, and up to 88% nucleotide sequence identity with their counterparts in Tembusu virus. FX2010 was transmitted without mosquito, and caused systemic infection and lesions in experimentally infected ducks. These results indicate that FX2010 and BYD virus are newly emerged Tembusu virus strains that cause an infectious disease in ducks.
authors: Shanghai Veterinary Research Institute, Shanghai, PR China.
authors: Pixi
authors: P
authors: Yan
authors: Youshu
authors: Y
authors: Zhao
authors: Xu
authors: X
authors: Zhang
authors: Dawei
authors: D
authors: Xu
authors: Xiaoguang
authors: X
authors: Dai
authors: Qiaoyang
authors: Q
authors: Teng
authors: Liping
authors: L
authors: Yan
authors: Jiewen
authors: J
authors: Zhou
authors: Xiwen
authors: X
authors: Ji
authors: Shumei
authors: S
authors: Zhang
authors: Guangqing
authors: G
authors: Liu
authors: Yanjun
authors: Y
authors: Zhou
authors: Yoshihiro
authors: Y
authors: Kawaoka
authors: Guangzhi
authors: G
authors: Tong
authors: Zejun
authors: Z
authors: Li
mesh_terms: D000818:Animals; D002642:Chick Embryo; D002681:China / Q000453:epidemiology; D002522:Chlorocebus aethiops; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D004279:DNA, Viral / Q000737:chemistry; D004196:Disease Outbreaks / Q000662:veterinary*; D004372:Ducks; D005347:Fibroblasts / Q000821:virology; D005416:Flavivirus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D018177:Flavivirus Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D010802:Phylogeny; D011201:Poultry Diseases / Q000453:epidemiology / Q000821:virology*; D013047:Specific Pathogen-Free Organisms; D014709:Vero Cells; D014779:Virus Replication
chemical_list: D004279:DNA, Viral