title: Constituents with tyrosinase inhibitory activities from branches of Ficus erecta var. sieboldii King.
abstract: Phytochemical investigation of the branches of Ficus erecta var. sieboldii King resulted in the isolation of eight constituents: p-hydroxybenzoic acid (1), methyl p-hydroxybenzoate (2), vanillic acid (3), methyl vanillate (4), syringic acid (5), β-sitosterol (6), α-amyrin acetate (7), and ethyl linoleate (8). Their chemical structures were identified via spectroscopic means as well as by comparing their data with literature values. Studies on tyrosinase inhibition activities were conducted for the isolated compounds. Among them, p-hydroxybenzoic acid (1) and methyl p-hydroxybenzoate (2) were identified as active tyrosinase inhibitors with IC(50) values of 0.98 ± 0.042 and 0.66 ± 0.025 mM, respectively, showing comparable activities to that of arbutin (IC(50) = 0.32 ± 0.015 mM), a standard control. Inhibition kinetics, as analyzed by Lineweaver-Burk plots, indicated that compounds 1 and 2 were competitive inhibitors of diphenolase of mushroom tyrosinase. Notably, isolated compounds 1-8 were reported for the first time as constituents of F. erecta.
authors: Department of Chemistry and Research Center for Cosmetic Science, Cheju National University, Jeju, Korea.
authors: Sung Hwan
authors: SH
authors: Park
authors: Tae-Heon
authors: TH
authors: Oh
authors: Sang Suk
authors: SS
authors: Kim
authors: Jung Eun
authors: JE
authors: Kim
authors: Sun Joo
authors: SJ
authors: Lee
authors: Nam Ho
authors: NH
authors: Lee
mesh_terms: D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D030681:Ficus / Q000737:chemistry*; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D014442:Monophenol Monooxygenase