title: The biomechanical behavior and host response to porcine-derived small intestine submucosa, pericardium and dermal matrix acellular grafts in a rat abdominal defect model.
abstract: Several porcine-derived acellular biologic grafts are increasingly used in abdominal wall reconstruction due to the limitations of synthetic meshes in many clinical situations. However, relatively little is known so far about their comparative mechanical characteristics and performance after defect repair. We therefore investigated three most commonly used porcine-derived acellular biomaterials, small intestine submucosa (P-SIS), pericardium (P-PC) and acellular dermal matrix (P-ADM) immediately after prepared, and their effectiveness, biomechanical and histological characteristics in repairing full-thickness abdominal defect in a rat model. P-PC had the best native performance in the burst strength, tensile strength and ball burst among the three porcine-derived scaffolds. P-SIS showed a significantly higher water vapor transmission in comparison with P-PC or P-ADM. Abdominal wall defects in rats were all satisfied repaired with P-SIS, P-PC or P-ADM. No laxity or fistula was observed in the repaired abdominal wall in the P-SIS group up to 8 weeks after surgery. However, there was a tendency for high postoperative abdominal eventration in the P-ADM and P-PC groups as compared with the P-SIS group. With regard to overall aspects of the postoperative laxity, intra-abdominal adhesion formation, tensile stress, stretchability, and degree of tissue ingrowth in terms of collagen deposition and neovascularization, P-SIS exhibits clear advantages over P-PC as well as P-ADM after large abdominal wall defect reconstruction.
authors: Department of General Surgery, Zhabei District Central Hospital, Zhabei Branch Hospital, Shanghai Chang Zheng Hospital, Second Military Medical University, Zhabei District, Shanghai, PR China.
authors: Jian
authors: J
authors: Zhang
authors: Guan Yu
authors: GY
authors: Wang
authors: Yi Pin
authors: YP
authors: Xiao
authors: Lie Ying
authors: LY
authors: Fan
authors: Qiang
authors: Q
authors: Wang
mesh_terms: D034861:Abdominal Wall / Q000473:pathology* / Q000601:surgery; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D020405:Dermis / Q000737:chemistry* / Q000637:transplantation; D005109:Extracellular Matrix / Q000737:chemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry* / Q000637:transplantation; D007421:Intestine, Small / Q000033:anatomy & histology*; D008297:Male; D008422:Materials Testing; D010496:Pericardium / Q000737:chemistry* / Q000637:transplantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D019651:Plastic Surgery Procedures; D013314:Stress, Mechanical; D013552:Swine; D013718:Tensile Strength; D019737:Transplants
chemical_list: D001672:Biocompatible Materials