title: Indication for sentinel lymph node biopsy for breast cancer when core biopsy shows ductal carcinoma in situ.
abstract: BACKGROUND
  The use of sentinel lymph node biopsy (SLNB) for ductal carcinoma in situ (DCIS) is controversial.
  
  
  METHODS
  A total of 103 primary breast cancer patients who were diagnosed with DCIS by needle biopsy preoperatively and underwent initial SLNB were analyzed retrospectively.
  
  
  RESULTS
  No sentinel nodal metastasis was detected in 66 patients with the final diagnosis of DCIS. However, 2 (5.4%) of 37 patients with invasive ductal carcinoma at final diagnosis had positive sentinel nodes. Multivariate logistic regression analysis identified 2 independent significant predictors of existence of invasive components: presence of a palpable tumor (odds ratio, 4.091; 95% confidential interval, 1.399-11.959; P = .010) and tumor size of 2.0 cm or larger on magnetic resonance imaging (odds ratio, 4.506; 95% confidence interval, 1.322-15.358; P = .016).
  
  
  CONCLUSIONS
  Initial SLNB should be considered for patients diagnosed with DCIS by needle biopsy when they have a high risk for harboring invasive ductal cancer preoperatively.
authors: Department of Breast and Endocrine Surgery, Osaka University, Graduate School of Medicine, Suita, Japan.
authors: Tomohiro
authors: T
authors: Miyake
authors: Kenzo
authors: K
authors: Shimazu
authors: Hiroshi
authors: H
authors: Ohashi
authors: Tetsuya
authors: T
authors: Taguchi
authors: Satsuki
authors: S
authors: Ueda
authors: Takahiro
authors: T
authors: Nakayama
authors: Seung Jin
authors: SJ
authors: Kim
authors: Katsuyuki
authors: K
authors: Aozasa
authors: Yasuhiro
authors: Y
authors: Tamaki
authors: Shinzaburo
authors: S
authors: Noguchi
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy; D055815:Young Adult