title: Synthesis of the C7-26 fragment of amphidinolides G and H.
abstract: A new approach to the synthesis of the C7-26 fragment of amphidinolides G and H was developed. In the sequence, the C7-18 portion of this fragment was synthesized using an acetylide coupling protocol, while an Evans alkylation and Sharpless asymmetric dihydroxylation were employed as key steps in construction of the C19-26 subfragment. Finally, both of these units were joined by utilizing an aldol coupling reaction to produce the target C7-26 fragment in good yield.
authors: Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Yokohama 223-8522, Japan.
authors: Akihiro
authors: A
authors: Hara
authors: Ryo
authors: R
authors: Morimoto
authors: Yuichi
authors: Y
authors: Ishikawa
authors: Shigeru
authors: S
authors: Nishiyama
mesh_terms: D000478:Alkylation; D018942:Macrolides / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D000097442:Amphidinolides
chemical_list: D018942:Macrolides; C414663:amphidinolide G; D000097442:Amphidinolides; C414664:amphidinolide H