title: Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD.
abstract: The 5HT2A receptor gene (HTR2A) polymorphisms rs7997012 and rs6311 have in some earlier studies been associated with serotonin selective reuptake inhibitor (SSRI) treatment response in major depressive disorder (MDD), but the findings are inconsistent. The aim of the present study was to test for an association between two HTR2A polymorphisms (rs7997012 and rs6311), their interaction and the Montgomery and Åsberg Depression Rating Scale (MADRS) score change after ECT or SSRI treatment. The total number of patients was 218. All were treated in outpatient care. Of these, 119 subjects had treatment-resistant MDD and were treated with ECT and 99 were depressive patients treated with SSRI. Treatment response was assessed by MADRS. Patients scoring <8 on post-treatment MADRS were considered remitters. Neither rs7997012 nor rs6311 HTR2A polymorphism was significantly associated with MADRS score change alone, but the interaction between them and gender explained 14% of the variance in MADRS score change. The finding suggests an association between MADRS score change and interaction of HTR2A polymorphisms, rs7997012 and rs6311 and gender.
authors: University of Tampere, Medical School, 33014 University of Tampere, Finland; Tampere Mental Health Centre, Hallituskatu 8 B, 33200 Tampere, Finland. merja.viikki@gmail.com
authors: Merja
authors: M
authors: Viikki
authors: Kaija
authors: K
authors: Huuhka
authors: Esa
authors: E
authors: Leinonen
authors: Ari
authors: A
authors: Illi
authors: Eija
authors: E
authors: Setälä-Soikkeli
authors: Martti
authors: M
authors: Huuhka
authors: Nina
authors: N
authors: Mononen
authors: Terho
authors: T
authors: Lehtimäki
authors: Olli
authors: O
authors: Kampman
mesh_terms: D000328:Adult; D000483:Alleles; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy; D004565:Electroconvulsive Therapy; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012737:Sex Factors; D016896:Treatment Outcome
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D017367:Selective Serotonin Reuptake Inhibitors