title: Age- and gender-related long-term renal outcome in patients with lupus nephritis.
abstract: OBJECTIVE
  To investigate age- and gender-related long-term renal outcome in patients with lupus nephritis (LN).
  
  
  METHODS
  This is a retrospective, chart review study of patients with LN at Chang Gung Memorial Hospital, Kaohsiung, between January 1986 and June 2004. All had undergone a renal biopsy that showed LN. The end point of outcome was chronic renal insufficiency (CRI), which was defined as 'doubling of baseline serum creatinine lasting for at least 6 months with a value at least 2  mg/dl.' The patients were categorized by age tertiles and gender. A 5-year survival curve was constructed to study the effect of age and gender on the outcome.
  
  
  RESULTS
  In total, 121 sets of patient data were evaluated. The study group included 104 women and 17 men. Of the study patients, 26 (21%) developed CRI after 5 years of follow-up. There was no significant difference among age groups in developing CRI (p = 0.23). In terms of gender, men had worse long-term renal outcome (p = 0.004) than women.
  
  
  CONCLUSIONS
  The long-term renal outcome of the LN patients did not differ among age groups, but was worse in men.
authors: Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors: C-Y
authors: CY
authors: Hsu
authors: W-C
authors: WC
authors: Chiu
authors: T-S
authors: TS
authors: Yang
authors: C-J
authors: CJ
authors: Chen
authors: Y-C
authors: YC
authors: Chen
authors: H-M
authors: HM
authors: Lai
authors: S-F
authors: SF
authors: Yu
authors: Y-J
authors: YJ
authors: Su
authors: T-T
authors: TT
authors: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008181:Lupus Nephritis / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000209:etiology; D012189:Retrospective Studies; D012737:Sex Factors; D055815:Young Adult
chemical_list: D003404:Creatinine