title: [Toxic liver injuries--a current view on pathogenesis. Part I].
abstract: Toxic liver injury poses an important heath problem in occupational medicine. Toxic response of this organ may arise from acute or chronic exposure to different substances. The final toxicological response to different toxicants may be defined as the regeneration of cells, loss of their function or necrosis. The morphology of toxic drug- or chemical-induced liver injury usuall differentiates into one of the following phenotypes: cholestatic injury, hepato- cellular injury, often associated with elevated l enzymes, mitochondrial injuries and delayed immunological injury. In this article, the authors present current knowledge of the pathogenesis of morphological changes in hepatocytes as the result of exposure to xenobiotics.
authors: Oddział Toksykologii, Klinika Chorób Zawodowych i Toksykologii, Instytut Medycyny Pracy im. prof. J. Nofera, Łódź.
authors: Marek
authors: M
authors: Bak
authors: Maciej
authors: M
authors: Czerniak
authors: Magda
authors: M
authors: Kicińska-Krogulska
authors: Aleksandra
authors: A
authors: Michowicz
authors: Anna
authors: A
authors: Krakowiak
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D005234:Fatty Liver / Q000139:chemically induced / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D009784:Occupational Diseases / Q000139:chemically induced* / Q000378:metabolism* / Q000517:prevention & control; D016273:Occupational Exposure / Q000009:adverse effects*; D012307:Risk Factors; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D015262:Xenobiotics