title: Effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants: a study in rats.
abstract: OBJECTIVE
  The present study aimed to assess the effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants in rats.
  
  
  METHODS
  Thirty-six rats were randomly divided into six groups: group 1, healthy rats (no aminoguanidine); group 2 and group 3, healthy rats receiving 10 and 20 mg/kg of aminoguanidine daily, respectively; group 4, diabetic rats (no aminoguanidine); and group 5 and group 6, diabetic rats receiving 10 and 20 mg/kg of aminoguanidine daily, respectively. In each rat an implant was inserted in the femur. After 28 d of healing, the rats were killed. The implants were removed by applying a counter-torque, and the maximum force required for the rupture of the bone-implant interface was recorded using an analog torque meter. The data were evaluated using analysis of variance and the Student's t-test.
  
  
  RESULTS
  In the healthy groups, no statistically significant difference could be observed in the average counter-torque values for implant removal, whereas in the diabetic groups, a daily dose of 20 mg/kg of aminoguanidine raised the counter-torque values to the values found in healthy rats.
  
  
  CONCLUSIONS
  The administration of 20 mg/kg of aminoguanidine daily in diabetic rats raised the biomechanical retention of the implants to the level observed in the healthy rat group.
authors: Pontifícia Universidade Católica de Minas Gerais (PUC-MG), Santa Efigênia, Brasil. rportog@gmail.com
authors: R P
authors: RP
authors: Guimarães
authors: P A D
authors: PA
authors: de Oliveira
authors: A M S D
authors: AM
authors: Oliveira
mesh_terms: D000496:Alloxan; D000818:Animals; D015921:Dental Implants; D017268:Dental Prosthesis Retention; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005269:Femur / Q000601:surgery; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D006146:Guanidines / Q000494:pharmacology*; D020007:Implants, Experimental; D016348:Osseointegration; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D019415:Torque
chemical_list: D015921:Dental Implants; D004791:Enzyme Inhibitors; D017127:Glycation End Products, Advanced; D006146:Guanidines; D000496:Alloxan; C004479:pimagedine