title: Side-chain peptide-synthetic polymer conjugates via tandem "ester-amide/thiol-ene" post-polymerization modification of poly(pentafluorophenyl methacrylate) obtained using ATRP.
abstract: Herein the concept of tandem postpolymerization modification as a versatile route to synthesize well-defined, highly functionalized polymers is introduced. Poly(pentafluorophenyl methacrylate) obtained by atom transfer radical polymerization was first modified with allylamine, which displaces the active ester to give well-defined polymers with pendant alkene groups, which are difficult to obtain by direct (radical) polymerization of allylic-functional monomers. The produced poly(allylmethacrylamide) was modified by a second postpolymerization modification reaction with a thiol-terminated peptide (CVPGVG) using AIBN as the radical source. NMR, IR, and SEC demonstrated successful conjugation onto the polymer to give a polymer-peptide hybrid material. This versatile strategy should extend the scope of controlled radical polymerization and "click"-type reactions.
authors: Rubber Technology Centre, Indian Institute of Technology, Kharagpur, 721302, WB, India. nks@rtc.iitkgp.ernet.in
authors: Nikhil K
authors: NK
authors: Singha
authors: Matthew I
authors: MI
authors: Gibson
authors: Bishnu P
authors: BP
authors: Koiry
authors: Maarten
authors: M
authors: Danial
authors: Harm-Anton
authors: HA
authors: Klok
mesh_terms: D000577:Amides / Q000737:chemistry; D002850:Chromatography, Gel; D004952:Esters / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D005464:Fluorobenzenes; D005466:Fluorocarbons
chemical_list: D000577:Amides; D004952:Esters; D008689:Methacrylates; D010455:Peptides; D011108:Polymers; C035583:pentafluorophenylmethacrylate; D005464:Fluorobenzenes; D005466:Fluorocarbons