title: A benign form of neuromyelitis optica: does it exist?
abstract: BACKGROUND
  Few data exist on a possible benign form of neuromyelitis optica (NMO).
  
  
  OBJECTIVE
  To identify NMO with a good outcome (go-NMO) among a large population of patients and to describe demographic and clinical variables associated with go-NMO vs standard NMO and benign multiple sclerosis.
  
  
  METHODS
  Observational retrospective multicenter study.
  
  
  METHODS
  Twenty-five medical centers in metropolitan France (MF) and 3 medical centers in the French West Indies (FWI).
  
  
  METHODS
  A total of 175 patients with NMO were retrospectively analyzed from 2 cohorts: 125 in MF and 50 patients of nonwhite race/ethnicity in the FWI. Patients in MF fulfilled the 2006 NMO criteria, whereas patients in the FWI fulfilled the 1999 or 2006 NMO criteria. Neuromyelitis optica and multiple sclerosis databases were reviewed, and patients with a score of 3 or lower on the Expanded Disability Status Scale after a 10-year follow-up period were considered to have go-NMO.
  
  
  METHODS
  Clinical, laboratory, and magnetic resonance imaging data and course of disability.
  
  
  RESULTS
  In MF, go-NMO was observed in 11 patients, including 3 untreated patients. In the FWI, NMO was severe because of disability related to optic neuritis. Compared with standard NMO, go-NMO was associated with a lower annualized relapse rate (0.3 vs 1.0, P < .01), and 8 of 11 patients with go-NMO showed complete regression of myelitis on magnetic resonance imaging during the disease course. Three patients experienced a disabling attack of NMO after 15 years of follow-up. A good outcome occurred less frequently among patients with NMO than among patients with multiple sclerosis (12.0% vs 22.4%, P = .03).
  
  
  CONCLUSIONS
  Among patients in MF, go-NMO occurs rarely. However, because a disabling attack may occur after a long follow-up period, a benign form of NMO cannot be defined.
authors: Hôpital Universitaire de Strasbourg, Service de Neurologie et Centre d'Investigation Clinique INSERM 1002, Strasbourg, France. nicolas.collongues@chru-Strasbourg.fr
authors: Nicolas
authors: N
authors: Collongues
authors: Philippe
authors: P
authors: Cabre
authors: Romain
authors: R
authors: Marignier
authors: Hèléne
authors: H
authors: Zéphir
authors: Caroline
authors: C
authors: Papeix
authors: Bertrand
authors: B
authors: Audoin
authors: Christine
authors: C
authors: Lebrun-Frenay
authors: Jean
authors: J
authors: Pelletier
authors: Bertrand
authors: B
authors: Fontaine
authors: Patrick
authors: P
authors: Vermersch
authors: Christian
authors: C
authors: Confavreux
authors: Jérôme
authors: J
authors: de Seze
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology; D009471:Neuromyelitis Optica / Q000175:diagnosis / Q000453:epidemiology*; D011859:Radiography; D012189:Retrospective Studies; D013116:Spinal Cord / Q000000981:diagnostic imaging; D014900:West Indies / Q000453:epidemiology