title: Estimating exogenous variables in data with more variables than observations.
abstract: Many statistical methods have been proposed to estimate causal models in classical situations with fewer variables than observations. However, modern datasets including gene expression data increase the needs of high-dimensional causal modeling in challenging situations with orders of magnitude more variables than observations. In this paper, we propose a method to find exogenous variables in a linear non-Gaussian causal model, which requires much smaller sample sizes than conventional methods and works even under orders of magnitude more variables than observations. Exogenous variables work as triggers that activate causal chains in the model, and their identification leads to more efficient experimental designs and better understanding of the causal mechanism. We present experiments with artificial data and real-world gene expression data to evaluate the method.
authors: The Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan. sogawa@ar.sanken.osaka-u.ac.jp
authors: Yasuhiro
authors: Y
authors: Sogawa
authors: Shohei
authors: S
authors: Shimizu
authors: Teppei
authors: T
authors: Shimamura
authors: Aapo
authors: A
authors: Hyvärinen
authors: Takashi
authors: T
authors: Washio
authors: Seiya
authors: S
authors: Imoto
mesh_terms: D000465:Algorithms; D015984:Causality; D016208:Databases, Factual; D030541:Databases, Genetic; D016014:Linear Models; D046228:Microarray Analysis / Q000379:methods; D016011:Normal Distribution; D025341:Principal Component Analysis