title: The use of bone graft substitutes in large cancellous voids: any specific needs?
abstract: Bone graft is the second most common transplantation tissue, with blood being by far the commonest. Autograft is considered ideal for grafting procedures, providing osteoinductive growth factors, osteogenic cells and an osteoconductive scaffold. Limitations, however, exist regarding donor site morbidity and graft availability. Allograft on the other hand poses the risk of disease transmission. Synthetic graft substitutes lack osteoinductive or osteogenic properties. Composite grafts combine scaffolding properties with biological elements to stimulate cell proliferation and differentiation and eventually osteogenesis. We present here an overview of bone graft substitutes available for clinical application in large cancellous voids.
authors: Department of Trauma & Orthopaedic Surgery, Clinic Universitary Hospital of Valladolid, Spain.
authors: Omar
authors: O
authors: Faour
authors: Rozalia
authors: R
authors: Dimitriou
authors: Charlotte A
authors: CA
authors: Cousins
authors: Peter V
authors: PV
authors: Giannoudis
mesh_terms: D001847:Bone Diseases / Q000473:pathology / Q000601:surgery*; D016026:Bone Marrow Transplantation; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000145:classification / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000009:adverse effects / Q000379:methods; D002130:Calcium Phosphates / Q000627:therapeutic use; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002516:Ceramics / Q000627:therapeutic use; D006801:Humans; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates