title: Gliosarcoma arising from a fibrillary astrocytoma.
abstract: We report a 67-year-old woman who was diagnosed with a gliosarcoma at a second operation after diagnosis of a fibrillary astrocytoma 5 months previously. Initially, she underwent a CT-guided stereotactic biopsy. Histological examination showed fibrillary astrocytoma (World Health Organization [WHO] grade II). Loss of heterozygosity (LOH) on 1p, 10q, and 19q was not detected. She received chemotherapy, but no radiotherapy. Five months after the biopsy, MRI revealed rapid tumor growth. Tissue obtained from partial removal of the tumor revealed gliosarcoma (WHO grade IV), and LOH on 10q and 19q was detected. The history, histopathology, and genetic alterations of this patient are discussed.
authors: Department of Neurosurgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
authors: Tatsuya
authors: T
authors: Kobayashi
authors: Keiichi
authors: K
authors: Sakai
authors: Tsuyoshi
authors: T
authors: Tada
authors: Yasuyuki
authors: Y
authors: Sekiguchi
authors: Yosuke
authors: Y
authors: Hara
authors: Kunihiko
authors: K
authors: Kodama
authors: Tetsuya
authors: T
authors: Goto
authors: Yuichiro
authors: Y
authors: Tanaka
authors: Kenji
authors: K
authors: Sano
authors: Jun
authors: J
authors: Nakayama
authors: Kazuhiro
authors: K
authors: Hongo
mesh_terms: D000368:Aged; D001254:Astrocytoma / Q000150:complications* / Q000235:genetics / Q000628:therapy; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D004358:Drug Therapy / Q000379:methods; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D018316:Gliosarcoma / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed / Q000379:methods; D014746:Vimentin / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin