title: Cardiovascular alterations heralded by intrathecal baclofen bolus.
abstract: We describe two patients in whom serious bradycardia and arterial hypotension occurred after a small intrathecal baclofen (ITB) test bolus. Both patients suffered from severe spasticity (one due to brain injury, one due to spinal cord injury). Medical history and diagnostic examinations revealed no previous cardiological problems. Ten minutes following a 50 μg ITB bolus, patient 1 developed bradycardia (58 bpm) and incomplete right branch block, lasting for 3 hours. In patient 2, a 20 μg ITB bolus was followed after 5 minutes by severe bradycardia (30 bpm) and hypotension (60/30 mmHg), without loss of consciousness, lasting for 10 minutes. Exaggerated muscle tone was alleviated in both patients after 2 hours by the applied doses. Neither patient underwent implantation of a permanent pump system, both were continued on oral baclofen. Despite numerous unremarkable repeat cardiological exams, both patients suffered fatal cardiac arrest one and two months later, respectively. Our observations suggest that ITB may herald cardiovascular dysfunction in predisposed patients. Careful cardiological examination before ITB treatment, and close monitoring during ITB testing in particular, is advised.
authors: IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.
authors: Carmela
authors: C
authors: Rifici
authors: Giangaetano
authors: G
authors: D'Aleo
authors: Piercataldo
authors: P
authors: D'Aleo
authors: Placido
authors: P
authors: Bramanti
authors: Leopold
authors: L
authors: Saltuari
authors: Markus
authors: M
authors: Kofler
mesh_terms: D000328:Adult; D001418:Baclofen / Q000008:administration & dosage*; D001919:Bradycardia / Q000188:drug therapy; D004562:Electrocardiography / Q000379:methods; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D009128:Muscle Spasticity / Q000188:drug therapy
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen