title: Determination of 48 pesticides and their main metabolites in water samples by employing sonication and liquid chromatography-tandem mass spectrometry.
abstract: In this work, a rapid and sensitive analytical multiresidue method has been developed for the simultaneous determination of 48 pesticides and 19 metabolites in waters (tap, leaching and sewage), using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with triple quadrupole in selected reaction monitoring (SRM) mode. The procedure involves initial single phase extraction of samples with acetonitrile by sonication, followed by liquid-liquid partition aided by "salting out" process using NaCl. Matrix influence on recoveries was evaluated for the three waters. More than 50% of the compound presented very low signal suppression. The method presents good linearity over the range assayed 10-500 μg L(-1) and the most frequent detection limits was 0.05 ng mL(-1). The average recovery by the LC-MS/MS method obtained for these compounds varied from 74.6 to 111.2% with a relative standard deviation between 2.5 and 8.9%. The proposed method was used to determine pesticides levels in leaching water samples from 5 lysimeters from an experimental greenhouse located in Murcia.
authors: Instituto Murciano de Investigación y Desarrollo Agrario y Alimentario, IMIDA, C/Mayor s/n, La Alberca, 30150 Murcia, Spain. jose.fenoll@carm.es
authors: José
authors: J
authors: Fenoll
authors: Pilar
authors: P
authors: Hellín
authors: Carmen M
authors: CM
authors: Martínez
authors: Pilar
authors: P
authors: Flores
authors: Simón
authors: S
authors: Navarro
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D057230:Limit of Detection; D016014:Linear Models; D009930:Organic Chemicals / Q000737:chemistry; D010573:Pesticide Residues / Q000032:analysis* / Q000378:metabolism*; D015203:Reproducibility of Results; D012997:Solvents / Q000737:chemistry; D013010:Sonication / Q000379:methods*; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry / Q000379:methods*; D013997:Time Factors; D014867:Water / Q000737:chemistry*
chemical_list: D009930:Organic Chemicals; D010573:Pesticide Residues; D012997:Solvents; D014867:Water