title: Control of mitochondrial volume by mitochondrial metabolic water.
abstract: It is well-known that mitochondrial volume largely controls mitochondrial functioning. We investigate whether metabolic water produced by oxidative phosphorylation could be involved in mitochondrial volume regulation. We modulated the generation of this water in liver mitochondria and assess their volume by two independent techniques. In liver mitochondria, the mitochondrial volume was specifically decreased when no water was produced independently of energetic parameters and uncoupling activity. In all other conditions associated with water generation, there was no significant change in mitochondrial metabolic volume. Altogether these data demonstrate that mitochondrial volume is regulated, independently of energetic status, by the mitochondrial metabolic water that acts as a signal.
authors: Université de Toulouse, UPS, UMR 5241 Métabolisme, Plasticité et Mitochondrie, BP 84 225, F-31 432 Toulouse Cedex 4, France.
authors: Louis
authors: L
authors: Casteilla
authors: Anne
authors: A
authors: Devin
authors: Audrey
authors: A
authors: Carriere
authors: Bénédicte
authors: B
authors: Salin
authors: Jacques
authors: J
authors: Schaeffer
authors: Michel
authors: M
authors: Rigoulet
mesh_terms: D000818:Animals; D008099:Liver / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D053142:Mitochondrial Size / Q000502:physiology*; D010085:Oxidative Phosphorylation; D051381:Rats; D017208:Rats, Wistar; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water