title: Advances in magnetic resonance imaging of articular cartilage.
abstract: The pathology, assessment, and management of articular cartilage lesions of the hip and knee have been the subject of considerable attention in the recent orthopaedic literature. MRI has long been an important tool in the diagnosis and management of articular cartilage pathology, but detecting and interpreting early cartilaginous degeneration with this technology has been difficult. Biochemical-based MRI has been advocated to detect early cartilaginous degenerative changes and assess cartilage repair. Techniques such as T2 mapping, T1rho (ie, T1 in the rotating frame), sodium MRI, and delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) take advantage of changes in the complex biochemical composition of articular cartilage and may help detect morphologic cartilaginous changes earlier than does conventional MRI. Although the newer modalities have been used primarily in the research setting, their ability to assess the microstructure of articular cartilage may eventually enhance the diagnosis and management of osteoarthritis.
authors: Department of Orthopaedic Surgery, NYU Hospital for Joint Disease, New York, NY, USA.
authors: Laith M
authors: LM
authors: Jazrawi
authors: Michael J
authors: MJ
authors: Alaia
authors: Gregory
authors: G
authors: Chang
authors: Erin F
authors: EF
authors: Fitzgerald
authors: Michael P
authors: MP
authors: Recht
mesh_terms: D002358:Cartilage, Articular / Q000473:pathology*; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007592:Joint Diseases / Q000175:diagnosis*; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA