title: Absence of cardiovascular disease risk factors in restless legs syndrome.
abstract: OBJECTIVE
  Restless legs syndrome (RLS) might represent a condition at risk of cardiovascular (and cerebrovascular) disease; the role of sleep periodic leg movements, sleep deprivation, and presence of common risk factors for heart disease in these patients remains to be determined. The aim of this study was to evaluate the eventual presence of risk factors for cerebrovascular disease in RLS.
  
  
  METHODS
  Eighty-seven consecutive patients affected by idiopathic RLS were included in this study together with 81 controls. Blood count, chemistry, and kidney function tests were obtained. We detected subjects suffering from diabetes mellitus, kidney diseases, heart diseases, disk herniation, neuropathy, blood diseases, liver diseases, artery diseases, dyslipidemia, or hypertension. Polysomnography was recorded in 66 patients, and cerebral neuroimaging was obtained in 59 patients with RLS.
  
  
  RESULTS
  None of the differences in blood test parameters was statistically significant; however, hypertension was found to be more frequent in controls and dyslipidemia was more frequent in patients with RLS, but this was explained by its higher frequency in patients also affected by obstructive sleep apnea. A diagnosis of cerebrovascular disease was posed for 14 patients with RLS (16.1%), but no predictive factor for its presence was found at the binomial logistic regression.
  
  
  CONCLUSIONS
  Our findings argue against the presence of an altered lipid metabolism as a risk factor for the development of cerebrovascular disease in patients with RLS, even if they do support the idea that cerebrovascular disease might be frequent in this condition.
authors: Department of Neurology I.C., Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy.
authors: F I I
authors: FI
authors: Cosentino
authors: D
authors: D
authors: Aricò
authors: B
authors: B
authors: Lanuzza
authors: A
authors: A
authors: Raggi
authors: G
authors: G
authors: Sciortino
authors: M
authors: M
authors: Tripodi
authors: R
authors: R
authors: Bella
authors: M
authors: M
authors: Zucconi
authors: R
authors: R
authors: Ferri
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D015897:Comorbidity / Q000639:trends; D050171:Dyslipidemias / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012148:Restless Legs Syndrome / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*