title: Dysplasia is more common in the distal than proximal colon in ulcerative colitis surveillance.
abstract: BACKGROUND
  In patients with long-standing ulcerative colitis (UC), current dysplasia surveillance guidelines recommend four-quadrant biopsies every 10 cm throughout the colon. However, this may be inefficient if neoplastic lesions are localized in particular segments of the colorectum. The aim was to determine whether a difference exists in the anatomic distribution of dysplasia discovered in UC patients undergoing colonoscopic surveillance.
  
  
  METHODS
  From an institutional database of over 700 patients with UC who underwent two or more surveillance colonoscopies between 1994-2006, we identified all patients with flat (endoscopically invisible) low-grade dysplasia (fLGD) or advanced neoplasia (colorectal cancer [CRC] or high-grade dysplasia [HGD]). Pathology reports were reviewed regarding the anatomic location of all dysplastic lesions. Fisher's exact test was used to compare the frequencies of neoplasia among the different colonic segments.
  
  
  RESULTS
  We identified 103 patients who progressed to any neoplasia (fLGD, HGD, or CRC). These patients underwent a total of 396 colonoscopies. The mean age at first surveillance colonoscopy was 48.6 years, with a mean UC disease duration of 18.2 years; 100% had extensive disease. Fifty-five patients developed advanced neoplasia. The rectosigmoid was found to have a significantly greater number of biopsies positive for advanced neoplasia and for any neoplasia compared to all other colonic segments (P < 0.0007); 71.2% of all advanced neoplasia was in the rectosigmoid.
  
  
  CONCLUSIONS
  The majority of dysplastic lesions identified in a surveillance program was detected in the rectosigmoid. Endoscopists should consider taking a greater percentage of biopsies in these segments as opposed to more proximal areas.
authors: Department of Medicine, Division of Gastroenterology, Mount Sinai School of Medicine, New York, New York 10029, USA.
authors: Robert
authors: R
authors: Goldstone
authors: Steven
authors: S
authors: Itzkowitz
authors: Noam
authors: N
authors: Harpaz
authors: Thomas
authors: T
authors: Ullman
mesh_terms: D003093:Colitis, Ulcerative / Q000150:complications / Q000473:pathology*; D003106:Colon / Q000473:pathology*; D003111:Colonic Polyps / Q000209:etiology / Q000473:pathology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000209:etiology / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000209:etiology / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies