title: Diabetes insipidus associated with hemophagocytic lymphohistiocytosis: first case report.
abstract: OBJECTIVE
  To report the first case of central diabetes insipidus associated with hemophagocytic lympho-histiocytosis.
  
  
  METHODS
  We describe the clinical course of a 75-year-old woman who developed febrile illness 1 month after receiving the H1N1 influenza vaccination. Shortly thereafter, she developed central diabetes insipidus, which responded to treatment with intranasal desmopressin acetate. She was then hospitalized with another febrile illness and diagnosed with hemophagocytic lymphohistiocytosis.
  
  
  RESULTS
  Magnetic resonance imaging of the pituitary gland was significant for plaquelike meningeal enhancement and thickening surrounding the infundibulum, which has been previously reported as a manifestation of histiocytosis.
  
  
  CONCLUSIONS
  We believe this is the first case of central diabetes insipidus associated with hemophagocytic lymphohistiocytosis.
authors: Department of Medicine, Division of Endocrinology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
authors: Utpal
authors: U
authors: Pajvani
authors: Michael L
authors: ML
authors: Lipton
authors: Martin M
authors: MM
authors: Grajower
mesh_terms: D000368:Aged; D003919:Diabetes Insipidus / Q000175:diagnosis*; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging