title: Implant microparticles--a new concept for non-invasive cancer therapy.
abstract: Some progress in cancer research was possible in recent years mainly due to important advances in nanotechnology. However, clinical use of nanomaterials is still hindered by limitations. In search of better performance and control of inoculated materials, the efficiency and toxicity of SBBC implant particles was assessed. B16 tumoral cells (murine melanoma) were subjected to SBCC particles using in vitro and in vivo experimental models. In vitro experiments concerning the growth inhibition of tumoral cells using SBCC particles were performed by Flow Cytometry and by MTT Assay. In vivo experimental model (C57BL/6 mice) was used to complete this investigation: weight, viability and tumoral dimension were monitored. An anti-proliferative activity on B16 tumoral cells and an ability to produce apoptosis were observed. A reduction of tumoral volume and a 54% survival rate in the treated animals compared to the controls was obtained. Our preliminary results showed that the SBCC implants were effective against B16 melanoma cells, while there is no toxicity associated.
authors: 'Low Temperature Plasma Laboratory, National Institute for Lasers, Plasma and Radiation Physics, Bucharest, Romania; 2Cantacuzino National Institute of Research and Development for Microbiology and Immunology, Bucharest, Romania. cristina.surdubob@plasmacoatings.ro
authors: Carmen Cristina
authors: CC
authors: Surdu-Bob
authors: Cristin
authors: C
authors: Coman
authors: Ana
authors: A
authors: Călugăru
authors: Lidia
authors: L
authors: Cremer
authors: Marius
authors: M
authors: Bădulescu
authors: Ene
authors: E
authors: Vlase
mesh_terms: D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D005260:Female; D005434:Flow Cytometry; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D053758:Nanoparticles / Q000008:administration & dosage