title: Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG.
abstract: BACKGROUND
  In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite-based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members.
  
  
  METHODS
  In an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome-wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups.
  
  
  RESULTS
  Of the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37 cM interval on 4q13-25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD scores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC, an important gene in PC biology.
  
  
  CONCLUSIONS
  These results will be useful in prioritizing future susceptibility gene discovery efforts in this common cancer.
authors: Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
authors: Lingyi
authors: L
authors: Lu
authors: Geraldine
authors: G
authors: Cancel-Tassin
authors: Antoine
authors: A
authors: Valeri
authors: Olivier
authors: O
authors: Cussenot
authors: Ethan M
authors: EM
authors: Lange
authors: Kathleen A
authors: KA
authors: Cooney
authors: James M
authors: JM
authors: Farnham
authors: Nicola J
authors: NJ
authors: Camp
authors: Lisa A
authors: LA
authors: Cannon-Albright
authors: Teuvo L J
authors: TL
authors: Tammela
authors: Johanna
authors: J
authors: Schleutker
authors: Josef
authors: J
authors: Hoegel
authors: Kathleen
authors: K
authors: Herkommer
authors: Christiane
authors: C
authors: Maier
authors: Walther
authors: W
authors: Vogel
authors: Fredrik
authors: F
authors: Wiklund
authors: Monica
authors: M
authors: Emanuelsson
authors: Henrik
authors: H
authors: Grönberg
authors: Kathleen E
authors: KE
authors: Wiley
authors: Sarah D
authors: SD
authors: Isaacs
authors: Patrick C
authors: PC
authors: Walsh
authors: Brian T
authors: BT
authors: Helfand
authors: Donghui
authors: D
authors: Kan
authors: William J
authors: WJ
authors: Catalona
authors: Janet L
authors: JL
authors: Stanford
authors: Liesel M
authors: LM
authors: FitzGerald
authors: Bo
authors: B
authors: Johanneson
authors: Kerry
authors: K
authors: Deutsch
authors: Laura
authors: L
authors: McIntosh
authors: Elaine A
authors: EA
authors: Ostrander
authors: Stephen N
authors: SN
authors: Thibodeau
authors: Shannon K
authors: SK
authors: McDonnell
authors: Scott
authors: S
authors: Hebbring
authors: Daniel J
authors: DJ
authors: Schaid
authors: Alice S
authors: AS
authors: Whittemore
authors: Ingrid
authors: I
authors: Oakley-Girvan
authors: Chih-Lin
authors: CL
authors: Hsieh
authors: Isaac
authors: I
authors: Powell
authors: Joan E
authors: JE
authors: Bailey-Wilson
authors: Cheryl D
authors: CD
authors: Cropp
authors: Claire
authors: C
authors: Simpson
authors: John D
authors: JD
authors: Carpten
authors: Daniela
authors: D
authors: Seminara
authors: S Lilly
authors: SL
authors: Zheng
authors: Jianfen
authors: J
authors: Xu
authors: Graham G
authors: GG
authors: Giles
authors: Gianluca
authors: G
authors: Severi
authors: John L
authors: JL
authors: Hopper
authors: Dallas R
authors: DR
authors: English
authors: William D
authors: WD
authors: Foulkes
authors: Lovise
authors: L
authors: Maehle
authors: Pal
authors: P
authors: Moller
authors: Michael D
authors: MD
authors: Badzioch
authors: Steve
authors: S
authors: Edwards
authors: Michelle
authors: M
authors: Guy
authors: Ros
authors: R
authors: Eeles
authors: Douglas
authors: D
authors: Easton
authors: William B
authors: WB
authors: Isaacs
mesh_terms: D000368:Aged; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D003627:Data Interpretation, Statistical; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D008126:Lod Score; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*