title: Recent admixture in an Indian population of African ancestry.
abstract: Identification and study of genetic variation in recently admixed populations not only provides insight into historical population events but also is a powerful approach for mapping disease loci. We studied a population (OG-W-IP) that is of African-Indian origin and has resided in the western part of India for 500 years; members of this population are believed to be descendants of the Bantu-speaking population of Africa. We have carried out this study by using a set of 18,534 autosomal markers common between Indian, CEPH-HGDP, and HapMap populations. Principal-components analysis clearly revealed that the African-Indian population derives its ancestry from Bantu-speaking west-African as well as Indo-European-speaking north and northwest Indian population(s). STRUCTURE and ADMIXTURE analyses show that, overall, the OG-W-IPs derive 58.7% of their genomic ancestry from their African past and have very little inter-individual ancestry variation (8.4%). The extent of linkage disequilibrium also reveals that the admixture event has been recent. Functional annotation of genes encompassing the ancestry-informative markers that are closer in allele frequency to the Indian ancestral population revealed significant enrichment of biological processes, such as ion-channel activity, and cadherins. We briefly examine the implications of determining the genetic diversity of this population, which could provide opportunities for studies involving admixture mapping.
authors: G.N. Ramachandran Knowledge Centre for Genome Informatics, Council of Scientific and Industrial Research, Institute of Genomics and Integrative Biology, Delhi, India.
authors: Ankita
authors: A
authors: Narang
authors: Pankaj
authors: P
authors: Jha
authors: Vimal
authors: V
authors: Rawat
authors: Arijit
authors: A
authors: Mukhopadhyay
authors: Arijit
authors: A
authors: Mukhopadhayay
authors: Debasis
authors: D
authors: Dash
authors: Analabha
authors: A
authors: Basu
authors: Mitali
authors: M
authors: Mukerji
mesh_terms: D000354:Africa, Western; D000483:Alleles; D044383:Black People / Q000235:genetics*; D030541:Databases, Genetic; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population / Q000706:statistics & numerical data*; D005838:Genotype; D006801:Humans; D007194:India; D015810:Linkage Disequilibrium; D044465:White People / Q000235:genetics*
chemical_list: D005819:Genetic Markers