title: Attitudes of Klinefelter men and their relatives towards TESE-ICSI.
abstract: OBJECTIVE
  At the start of the implementation of TESE-ICSI for Klinefelter men in the Netherlands, we aimed to evaluate their wish to father children and their attitudes towards this artificial reproduction technique.
  
  
  METHODS
  Questionnaires were distributed to members of the Dutch Klinefelter Association (n = 365) and to Klinefelter cases known at our Department (n = 58). Questions addressed several aspects: socio-demographic characteristics, ascertainment of diagnosis, children and child wish, and TESE-ICSI. Data were characterized using descriptive statistics.
  
  
  RESULTS
  A total of 260 questionnaires (corresponding to 194 cases, 46%) were returned. A possible wish to father children was reported by 90% of Klinefelter men. 70% of Klinefelter men and 74% of their partners would (probably) opt for TESE-ICSI.
  
  
  CONCLUSIONS
  The majority of Dutch Klinefelter men and their partners desire to have children and have a positive attitude towards TESE-ICSI. Concerns include the risk of congenital malformations/developmental delay of the child and the limited success rate of TESE-ICSI.
authors: Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands. m.maiburg@umcutrecht.nl
authors: Merel C
authors: MC
authors: Maiburg
authors: Alissia C
authors: AC
authors: Hoppenbrouwers
authors: Henk F
authors: HF
authors: van Stel
authors: Jacques C
authors: JC
authors: Giltay
mesh_terms: D000328:Adult; D000368:Aged; D005190:Family / Q000523:psychology*; D005260:Female; D006801:Humans; D007713:Klinefelter Syndrome / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods / Q000523:psychology*; D053625:Sperm Retrieval / Q000523:psychology*