title: Protein translation in Plasmodium parasites.
abstract: The protein translation machinery of the parasite Plasmodium is the target of important anti-malarial drugs, and encompasses many promising targets for future drugs. Plasmodium parasites have three subcellular compartments that house genomes; the nucleus, mitochondrion and apicoplast, and each requires its own compartmentalized transcription and translation apparatus for survival. Despite the availability of the complete genome sequence that should reveal the requisite elements for all three compartments, our understanding of the translation machineries is patchy. We review what is known about cytosolic and organellar translation in Plasmodium and discuss the molecules that have been identified through genome sequencing and post-genomic analysis. Some translation components are yet to be found in Plasmodium, whereas others appear to be shared between translationally active organelles.
authors: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, 3010 Australia.
authors: Katherine E
authors: KE
authors: Jackson
authors: Saman
authors: S
authors: Habib
authors: Magali
authors: M
authors: Frugier
authors: Rob
authors: R
authors: Hoen
authors: Sameena
authors: S
authors: Khan
authors: James S
authors: JS
authors: Pham
authors: Lluís
authors: L
authors: Ribas de Pouplana
authors: Miriam
authors: M
authors: Royo
authors: Manuel A S
authors: MA
authors: Santos
authors: Amit
authors: A
authors: Sharma
authors: Stuart A
authors: SA
authors: Ralph
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism; D000962:Antimalarials / Q000494:pharmacology; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D017125:Genes, Protozoan; D054629:Genome, Mitochondrial; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D008928:Mitochondria / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D010961:Plasmodium / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism
chemical_list: D000962:Antimalarials; D015800:Protozoan Proteins; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases