title: Fish oil feeding up-regulates the expression of 5-aminolevulinate synthase 2 mRNA in rat brain.
abstract: In this study, we investigated the effect of fish oil on gene expression in the cerebral cortex, and found that 5-aminolevulinate synthase 2 (ALAS2) mRNA expression was up-regulated by fish oil feeding. ALAS2 promoter activity was found to be regulated by retinoic acid. Our results suggest that fish oil modulates neuronal functions via heme synthesis.
authors: Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University, Japan.
authors: Tomoaki
authors: T
authors: Haraguchi
authors: Noriyuki
authors: N
authors: Yanaka
authors: Yuko
authors: Y
authors: Eguchi
authors: Takahiro
authors: T
authors: Kudo
authors: Atsuko
authors: A
authors: Hirata
authors: Norihisa
authors: N
authors: Kato
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000378:metabolism; D005395:Fish Oils / Q000008:administration & dosage* / Q000378:metabolism; D015870:Gene Expression; D006418:Heme / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D014212:Tretinoin / Q000737:chemistry / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D005395:Fish Oils; D012333:RNA, Messenger; D004281:Docosahexaenoic Acids; D006418:Heme; D014212:Tretinoin; D000624:5-Aminolevulinate Synthetase