title: Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water--participation of Pt nanoparticles.
abstract: Electrolyzed reduced water (ERW) contains a large amount of molecular hydrogen and a small amount of Pt nanoparticles (Pt NPs). We have found that ERW significantly extended the lifespan of Caenorhabditis elegans in a novel culture medium designated Water Medium. In this study, we found that synthetic Pt NPs at ppb levels significantly extended the nematode lifespan and scavenged reactive oxygen species (ROS) in the nematode induced by paraquat treatment. In contrast, a high concentration of dissolved molecular hydrogen had no significant effect on the lifespan of the nematode. These findings suggest that the Pt NPs in ERW, rather than the molecular hydrogen, extend the longevity of the nematode, at least partly by scavenging ROS.
authors: Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan.
authors: Hanxu
authors: H
authors: Yan
authors: Tomoya
authors: T
authors: Kinjo
authors: Huaize
authors: H
authors: Tian
authors: Takeki
authors: T
authors: Hamasaki
authors: Kiichiro
authors: K
authors: Teruya
authors: Shigeru
authors: S
authors: Kabayama
authors: Sanetaka
authors: S
authors: Shirahata
mesh_terms: D000818:Animals; D018407:Bacterial Physiological Phenomena; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000378:metabolism*; D003470:Culture Media / Q000737:chemistry*; D004572:Electrolysis; D006859:Hydrogen / Q000032:analysis; D050296:Microbial Viability; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D018384:Oxidative Stress; D010984:Platinum / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014867:Water / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*
chemical_list: D003470:Culture Media; D017382:Reactive Oxygen Species; D014867:Water; D010984:Platinum; D006859:Hydrogen