title: Visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: comparison of 2D and 3D real inversion recovery imaging.
abstract: OBJECTIVE
  Endolymphatic hydrops of Ménière's disease has been visualized after intratympanic injection of gadopentetate dimeglumine (Gd-DTPA) using a 3-dimensional (3D) inversion-recovery sequence with real reconstruction (3D real IR). This technique enables differentiation of bone and endo- and perilymph space on a single image but requires 15 min of scan time. Therefore, we compared it with 2D real IR, which is faster.
  
  
  METHODS
  We investigated 10 ears in 9 patients with suspected Ménière's disease. Twenty-four hours after intratympanic administration of 8-fold diluted Gd-DTPA, we obtained 3D and 2D real IR images as well as magnetic resonance (MR) cisternography at 3 tesla. Three radiologists independently graded the degree of endolymphatic hydrops according to previously proposed criteria. Contrast-to-noise ratio (CNR) between peri- and endolymph was measured.
  
  
  RESULTS
  We could evaluate the degree of endolymphatic hydrops in 9 cochleas and 10 vestibules but not in a tenth cochlea, which was too faintly enhanced on both 2D and 3D real IR. Grading of all evaluated cochleas and vestibules agreed completely among the 3 radiologists. Evaluation on 2D real IR and 3D real IR also agreed completely. Mean CNR was significantly higher on 3D than 2D real IR (P<0.05), and CNR on both correlated significantly (r = 0.872).
  
  
  CONCLUSIONS
  Endolymphatic hydrops in Ménière's disease can be evaluated with 2D as well as 3D real IR and in a shorter scan time.
authors: Department of Radiology, Nagoya University, Graduate School of Medicine, Shouwa-ku, Nagoya, Japan. naganawa@med.nagoya-u.ac.jp
authors: Shinji
authors: S
authors: Naganawa
authors: Michihiko
authors: M
authors: Sone
authors: Masahiro
authors: M
authors: Yamazaki
authors: Hisashi
authors: H
authors: Kawai
authors: Tsutomu
authors: T
authors: Nakashima
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D018159:Endolymphatic Hydrops / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008575:Meniere Disease / Q000150:complications*; D008875:Middle Aged
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA