title: [Budget impact analysis of the first-line treatment of relapsing remitting multiple sclerosis in Spain].
abstract: OBJECTIVE
  To assess the budget impact of the treatment for relapsing remitting multiple sclerosis (RRMS), interferons, and glatiramer acetate, from the National Health System perspective in Spain.
  
  
  METHODS
  A budget impact model was designed to compare the cost of RRMS treatment in different settings, using a five year time-horizon, considering different percentages of administration of each medication. A reference setting o base case using all the available first line treatments (interferons and glatiramer acetate) was compared with five alternatives scenarios excluding each one of these treatments. The cost analysis (euros, year 2010) includes direct medical resources (drugs, administration, visits, disease management, diagnostic tests). Unitary cost data was obtained from the health costs database e-Salud and drugs catalogue.
  
  
  RESULTS
  Considering a cohort of 22 255 patients with RRMS, the mean global budget impact per year would be 260 775 470 euros in the base case. The setting that excluded glatiramer acetate increases the budget impact in a 3.23% (372 euros per patient per year). Pharmacological costs were the key drivers of total cost (90%).
  
  
  CONCLUSIONS
  The use of glatiramer acetate in the first-line-treatment of RRMS patients is a cost-saving strategy, which may decrease the budget impact from the National Health System perspective in Spain.
authors: Departamento Médico, Teva Pharma SLU, Alcobendas, Madrid, España.
authors: R
authors: R
authors: Sánchez-De la Rosa
authors: E
authors: E
authors: Sabater
authors: M A
authors: MA
authors: Casado
mesh_terms: D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000191:economics / Q000627:therapeutic use; D016899:Interferon-beta / Q000191:economics / Q000627:therapeutic use; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000191:economics*; D010455:Peptides / Q000191:economics / Q000627:therapeutic use; D013030:Spain; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D010455:Peptides; D000068717:Glatiramer Acetate; D016899:Interferon-beta