title: Sleep disordered breathing in community dwelling elderly: associations with cardiovascular disease, impaired systolic function, and mortality after a six-year follow-up.
abstract: BACKGROUND
  Sleep disordered breathing (SDB), cardiovascular disease (CVD) and impaired cardiac function are common in elderly people. We investigated the association of SDB and mortality in a community dwelling elderly population, considering CVD and objectively measured impaired cardiac function have been poorly studied thus far.
  
  
  OBJECTIVE
  To investigate whether SDB is a factor that affects mortality in elderly people, with a focus on those with CVD and/or signs of impaired cardiac function.
  
  
  METHODS
  A prospective cohort design was used and 331 community dwelling elderly aged 71-87 years underwent one-night polygraphic recordings in the subjects' homes. CVD and systolic function were objectively established. Mortality data were collected after 6 years.
  
  
  RESULTS
  In the total population there were no significant associations between mortality and SDB. In those with CVD and impaired systolic function, as measured by NT-proBNP, oxygen desaturation index (ODI) ≥10 was associated with mortality. The hazard ratio of 3.0 (CI 95% 1.1-8.6, p=0.03) remained statistically significant after adjustments for age, gender, diabetes and plasma values of NT-proBNP.
  
  
  CONCLUSIONS
  SDB in community dwelling elderly has no overall association to mortality irrespective of degree of SDB. However, hypoxic events (i.e., ODI ≥10) were associated with mortality in the group who had CVD in combination with impaired systolic function.
authors: Department of Cardiology, Linköping University Hospital, S-58183 Linköping, Sweden. peter.johansson@aries.vokby.se
authors: Peter
authors: P
authors: Johansson
authors: Urban
authors: U
authors: Alehagen
authors: Martin
authors: M
authors: Ulander
authors: Eva
authors: E
authors: Svanborg
authors: Ulf
authors: U
authors: Dahlström
authors: Anders
authors: A
authors: Broström
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood; D015995:Prevalence; D011446:Prospective Studies; D012111:Residence Characteristics / Q000706:statistics & numerical data; D012424:Rural Population / Q000706:statistics & numerical data; D012891:Sleep Apnea Syndromes / Q000401:mortality* / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013599:Systole / Q000502:physiology*
chemical_list: D010100:Oxygen