title: Dependence of cell survival on instantaneous dose rate of a linear accelerator.
abstract: OBJECTIVE
  With the development of flattening filter-free linear accelerators for radiotherapy, the instantaneous dose rate has increased by approximately a factor 4. This leads to the question of whether there may be a radiobiological consequence. The present study investigates the radiobiological effect of this high instantaneous dose rate on two cell lines.
  
  
  METHODS
  A Varian Trilogy TX linear accelerator was used to directly compare the effect of three different dose rates (5.01, 9.99 and 29.91 Gy/min, with instantaneous dose rates in the pulse of 56.5, 112.8 and 338 Gy/s) on clonogenic survival. V79 and FaDu(DD) cells were irradiated with doses in a range from 1 to 10 Gy in order to obtain dose response curves.
  
  
  RESULTS
  For both cell lines, there is not observed any effect of the instantaneous dose rate on cell survival.
authors: Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark. bsin@oncology.dk
authors: Brita Singers
authors: BS
authors: Sørensen
authors: Anne
authors: A
authors: Vestergaard
authors: Jens
authors: J
authors: Overgaard
authors: Lars Hjorth
authors: LH
authors: Præstegaard
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D010315:Particle Accelerators; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D011853:Radiobiology; D012680:Sensitivity and Specificity; D014407:Tumor Cells, Cultured / Q000528:radiation effects