title: The human proteome project: current state and future direction.
abstract: After the successful completion of the Human Genome Project, the Human Proteome Organization has recently officially launched a global Human Proteome Project (HPP), which is designed to map the entire human protein set. Given the lack of protein-level evidence for about 30% of the estimated 20,300 protein-coding genes, a systematic global effort will be necessary to achieve this goal with respect to protein abundance, distribution, subcellular localization, interaction with other biomolecules, and functions at specific time points. As a general experimental strategy, HPP research groups will use the three working pillars for HPP: mass spectrometry, antibody capture, and bioinformatics tools and knowledge bases. The HPP participants will take advantage of the output and cross-analyses from the ongoing Human Proteome Organization initiatives and a chromosome-centric protein mapping strategy, termed C-HPP, with which many national teams are currently engaged. In addition, numerous biologically driven and disease-oriented projects will be stimulated and facilitated by the HPP. Timely planning with proper governance of HPP will deliver a protein parts list, reagents, and tools for protein studies and analyses, and a stronger basis for personalized medicine. The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators.
authors: CEA, Life Sciences Division, Fontenay-aux-Roses, France. pierre.legrain@cea.fr
authors: Pierre
authors: P
authors: Legrain
authors: Ruedi
authors: R
authors: Aebersold
authors: Alexander
authors: A
authors: Archakov
authors: Amos
authors: A
authors: Bairoch
authors: Kumar
authors: K
authors: Bala
authors: Laura
authors: L
authors: Beretta
authors: John
authors: J
authors: Bergeron
authors: Christoph H
authors: CH
authors: Borchers
authors: Garry L
authors: GL
authors: Corthals
authors: Catherine E
authors: CE
authors: Costello
authors: Eric W
authors: EW
authors: Deutsch
authors: Bruno
authors: B
authors: Domon
authors: William
authors: W
authors: Hancock
authors: Fuchu
authors: F
authors: He
authors: Denis
authors: D
authors: Hochstrasser
authors: György
authors: G
authors: Marko-Varga
authors: Ghasem Hosseini
authors: GH
authors: Salekdeh
authors: Salvatore
authors: S
authors: Sechi
authors: Michael
authors: M
authors: Snyder
authors: Sudhir
authors: S
authors: Srivastava
authors: Mathias
authors: M
authors: Uhlén
authors: Cathy H
authors: CH
authors: Wu
authors: Tadashi
authors: T
authors: Yamamoto
authors: Young-Ki
authors: YK
authors: Paik
authors: Gilbert S
authors: GS
authors: Omenn
mesh_terms: D003226:Congresses as Topic; D006801:Humans; D019451:Information Management; D007391:International Cooperation; D020543:Proteome / Q000737:chemistry / Q000378:metabolism; D040901:Proteomics / Q000191:economics / Q000458:organization & administration / Q000639:trends*
chemical_list: D020543:Proteome