title: Zorrimidazolone, a bioactive alkaloid from the non-indigenous mediterranean stolidobranch Polyandrocarpa zorritensis.
abstract: Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.
authors: The NeaNat Group, Department of Chemistry of Natural Products, University of Napoli "Federico II", Via D. Montesano 49, Napoli 80131, Italy.
authors: Anna
authors: A
authors: Aiello
authors: The NeaNat Group, Department of Chemistry of Natural Products, University of Napoli "Federico II", Via D. Montesano 49, Napoli 80131, Italy.
authors: Ernesto
authors: E
authors: Fattorusso
authors: The NeaNat Group, Department of Chemistry of Natural Products, University of Napoli "Federico II", Via D. Montesano 49, Napoli 80131, Italy.
authors: Concetta
authors: C
authors: Imperatore
authors: Department of Experimental Pharmacology, University of Napoli "Federico II", Via D. Montesano 49, Napoli 80131, Italy.
authors: Carlo
authors: C
authors: Irace
authors: C.S.I.A.S. (Interdepartmental Service Center for Spectroscopic Analysis), University of Napoli "Federico II", Via D. Montesano 49, Napoli 80131, Italy.
authors: Paolo
authors: P
authors: Luciano
authors: The NeaNat Group, Department of Chemistry of Natural Products, University of Napoli "Federico II", Via D. Montesano 49, Napoli 80131, Italy.
authors: Marialuisa
authors: 0000-0002-4515-3014
authors: M
authors: Menna
authors: Department of Experimental Pharmacology, University of Napoli "Federico II", Via D. Montesano 49, Napoli 80131, Italy.
authors: Rita
authors: R
authors: Santamaria
authors: The NeaNat Group, Department of Chemistry of Natural Products, University of Napoli "Federico II", Via D. Montesano 49, Napoli 80131, Italy.
authors: Rocco
authors: R
authors: Vitalone
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006367:HeLa Cells; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008522:Mediterranean Sea; D051381:Rats; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D007093:Imidazoles; C569003:zorrimidazolone