title: Serum paraoxonase 1 activity predicts arterial stiffness in renal transplant recipients.
abstract: OBJECTIVE
  Paraoxanase 1 (PON 1) has been shown to protect against atherosclerosis by modifying lipoproteins. Its activity decreases in dialysis patients but is restored after transplantation. Whether it affects arterial stiffness is unclear. In this study we aimed to investigate the effects of PON 1 on arterial stiffness in renal transplant patients.
  
  
  METHODS
  Seventy renal transplant recipients were enrolled. Arterial stiffness was measured using a Syphmocor device. PON-1 activity was assessed from the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol.
  
  
  RESULTS
  Mean age was 39.0 ± 9.6 years and 5.7% of the patients were diabetic. Post-transplant follow-up time was 46.7 ± 37.9 months. Eighty-five percent received anti-hypertensive and 12.9% anti-hyperlipidemic medication. Mean PON1 activity was 75.9 ± 52.4 U/L. PON1 activity was negatively correlated with systolic and diastolic blood pressure, mean arterial pressure, LDL-cholesterol and carotid-femoral pulse wave velocity (cf-PWV). Mean c-f PWV was 8.10 ± 1.39 m/s. Cf-PWV was positively correlated with age, systolic and diastolic blood pressure, mean arterial pressure, proteinuria and negatively correlated with PON1, PON1/HDL ratio and creatinine clearance. In linear regression analysis, PON1 was a predictor of cf-PWV in a model that included age, gender, diabetes, mean arterial pressure, urine protein level, creatinine clearance and PON 1.
  
  
  CONCLUSIONS
  Reduced PON1 activity is significantly associated with increased arterial stiffness. The results of this study show the possible role of PON1 for arterial stiffening in renal transplant recipients.
authors: Ege University School of Medicine, Division of Nephrology, Izmir, Turkey. ozkangungor@yahoo.com.tr
authors: Ozkan
authors: O
authors: Gungor
authors: Fatih
authors: F
authors: Kircelli
authors: Meltem Sezis
authors: MS
authors: Demirci
authors: Pinar
authors: P
authors: Tuncel
authors: Ali Riza
authors: AR
authors: Sisman
authors: Erhan
authors: E
authors: Tatar
authors: Ender
authors: E
authors: Hur
authors: Gulay
authors: G
authors: Asci
authors: Ercan
authors: E
authors: Ok
authors: Huseyin
authors: H
authors: Toz
mesh_terms: D000328:Adult; D001158:Arteries / Q000473:pathology*; D043303:Aryldialkylphosphatase / Q000097:blood*; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D059289:Vascular Stiffness
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human