title: Efficacy of emodepside plus toltrazuril (Procox(®) oral suspension for dogs) against Toxocara canis, Uncinaria stenocephala and Ancylostoma caninum in dogs.
abstract: The efficacy of emodepside plus toltrazuril (Procox® oral suspension for dogs) against different species of gastrointestinal nematodes (Toxocara canis, Ancylostoma caninum, Uncinaria stenocephala) was evaluated in nine randomised,blinded and placebo-controlled laboratory studies in naturally or experimentally infected dogs. The product was used at the proposed minimum dose of 0.45 mg emodepside and 9 mg toltrazuril per kg body weight. Efficacy was calculated based on worm counts after necropsy. Worm burdens in the control dogs ranged between 0 and 409 worms of the respective stage for T. canis and between 4 and 655 worms for hookworms. The studies demonstrated 100 % efficacy of emodepside/toltrazuril suspension against mature adult, ≥ 94.7 %efficacy against immature adult and 99.3 % efficacy against the L4 larval stage of T. canis. The efficacy against mature adult A. caninum was ≥ 99.5 % and the efficacy against mature adult U. stenocephala was 100 %. All differences between treatment and control groups were statistically significant and no gender effect was found. It can be concluded that the emodepside/toltrazuril suspension represents a safe and highly effective product in dogs with nematode (T. canis, hookworms) infection.
authors: Bayer Animal Health GmbH, Leverkusen, Germany.
authors: Annette
authors: A
authors: Schimmel
authors: Iris
authors: I
authors: Schroeder
authors: Gertraut
authors: G
authors: Altreuther
authors: Terry
authors: T
authors: Settje
authors: Samuel
authors: S
authors: Charles
authors: Sonja
authors: S
authors: Wolken
authors: Dawid J
authors: DJ
authors: Kok
authors: Jennifer
authors: J
authors: Ketzis
authors: David
authors: D
authors: Young
authors: Douglas
authors: D
authors: Hutchens
authors: Klemens J
authors: KJ
authors: Krieger
mesh_terms: D000284:Administration, Oral; D000722:Ancylostoma / Q000187:drug effects* / Q000472:pathogenicity; D000723:Ancylostomatoidea / Q000187:drug effects* / Q000472:pathogenicity; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use; D047630:Depsipeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004311:Double-Blind Method; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D006725:Hookworm Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D007814:Larva / Q000187:drug effects / Q000469:parasitology; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D017166:Toxocara canis / Q000187:drug effects* / Q000472:pathogenicity; D014120:Toxocariasis / Q000188:drug therapy* / Q000469:parasitology; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000871:Anthelmintics; D047630:Depsipeptides; D004338:Drug Combinations; D014227:Triazines; C036670:toltrazuril; C468987:emodepside