title: A rare cause of pulmonary infiltrates one should be aware of: a case of daptomycin-induced acute eosinophilic pneumonia.
abstract: We report a 69-year-old patient who developed fever and dyspnea 3 weeks after the initiation of daptomycin therapy for spondylodiscitis with lumbar epidural and bilateral psoas abscesses due to ampicillin- and high-level-gentamicin-resistant Enterococcus faecium. There was profound hypoxia and the chest X-ray showed extensive patchy infiltrates bilaterally. A bronchoalveolar lavage revealed 30% eosinophils and results of microbiological studies were normal. Daptomycin-induced eosinophilic pneumonia was diagnosed and the patient rapidly improved after the discontinuation of daptomycin and a brief course of prednisone. Increased attention must be paid to this rare but serious side effect of daptomycin.
authors: Medical University Department, Kantonsspital Aarau, Tellstrasse, 5001 Aarau, Switzerland.
authors: C
authors: C
authors: Rether
authors: A
authors: A
authors: Conen
authors: M
authors: M
authors: Grossenbacher
authors: W C
authors: WC
authors: Albrich
mesh_terms: D000038:Abscess / Q000188:drug therapy; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D017576:Daptomycin / Q000008:administration & dosage* / Q000009:adverse effects*; D015299:Discitis / Q000150:complications / Q000188:drug therapy; D016984:Enterococcus faecium; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D013902:Radiography, Thoracic
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin