title: [Progress of researches on mechanism of acupuncture therapy underlying improvement of acute cerebral hemorrhage].
abstract: In the present paper, the authors review the progress of researches on the mechanism of acupuncture therapy underlying improvement of acute cerebral hemorrhage from experimental studies and research methods. The effects of acupuncture intervention mainly involve (1) lessening inflammatory reactions, (2) reducing impairment of free radicals and excitatory amino acids on cerebral neurons, (3) balancing release of vascular bioactive substances to increase regional cerebral blood flow, and (4) promoting repair and regeneration of the neural tissue, etc. In regard to the research methods, many new biological techniques such as biological molecular approaches, neuro-cellular chemical methods, reverse transcription-polymerase chain reaction (RT-PCR) or quantitative real time-PCR, situ hybridization, western blotting, electron microscope, etc., have been extensively applied to researches on the underlying mechanism of acupuncture therapy for cerebral infarction. In addition, the authors also pointed out that in spite of achieving some bigger progresses in experimental studies, most of the results basically reflect static, isolated and regional changes rather than dynamic and whole body changes. For this reason, more vivo research techniques and noninvasive research methods are highly recommended to be used in the future research on the underlying mechanisms of acupuncture therapy for acute cerebral ischemia.
authors: Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Chinese Medicine, China. haha84122@163.com
authors: Fan
authors: F
authors: Wang
authors: Hai-qiao
authors: HQ
authors: Wang
authors: Gui-rong
authors: GR
authors: Dong
mesh_terms: D015670:Acupuncture Therapy; D000818:Animals; D002543:Cerebral Hemorrhage / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D002560:Cerebrovascular Circulation; D006801:Humans