title: B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis.
abstract: Although it has been recognized that ectopic follicle-like B cell aggregate formation is common in the lungs of patients with tuberculosis, the role of infiltrated B cells in human tuberculosis remains to be elucidated. In the present study, we showed that ectopic B cell aggregate formation was associated with containment of Mycobacterium tuberculosis. The area ratio of ectopic B cell aggregates was correlated with localized IL-17 mRNA expression and peripheral TGF-β and IL-6 mRNA expression. Depletion of B cells from pleural fluid mononuclear cells resulted in significantly diminished M. tuberculosis antigen-specific IL-17 and IL-22 production, but not in IFN-γ secretion. Therefore, ectopic lung B cell formation is important for containment of M. tuberculosis, and up-regulation of IL-17 and IL-22 responses may be an important mechanism underlying the protective role B cells in human tuberculosis.
authors: Shenzhen Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Shenzhen Third People's Hospital, Guangdong Medical College, Shenzhen, China.
authors: Mingxia
authors: M
authors: Zhang
authors: Zheng
authors: Z
authors: Wang
authors: Michael W
authors: MW
authors: Graner
authors: Lin
authors: L
authors: Yang
authors: Mingfeng
authors: M
authors: Liao
authors: Qianting
authors: Q
authors: Yang
authors: Jizhou
authors: J
authors: Gou
authors: Yuzhen
authors: Y
authors: Zhu
authors: Chi
authors: C
authors: Wu
authors: Haiying
authors: H
authors: Liu
authors: Boping
authors: B
authors: Zhou
authors: Xinchun
authors: X
authors: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000942:Antigens, Bacterial; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002449:Cell Aggregation; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis* / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D007378:Interleukins / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D015854:Up-Regulation; D000097043:Interleukin-22
chemical_list: D000942:Antigens, Bacterial; D016207:Cytokines; D020381:Interleukin-17; D015850:Interleukin-6; D007378:Interleukins; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D000097043:Interleukin-22; C508600:IL6 protein, human