title: Computational oncology.
abstract: Oncology research has traditionally been conducted using techniques from the biological sciences. The new field of computational oncology has forged a new relationship between the physical sciences and oncology to further advance research. By applying physics and mathematics to oncologic problems, new insights will emerge into the pathogenesis and treatment of malignancies. One major area of investigation in computational oncology centers around the acquisition and analysis of data, using improved computing hardware and software. Large databases of cellular pathways are being analyzed to understand the interrelationship among complex biological processes. Computer-aided detection is being applied to the analysis of routine imaging data including mammography and chest imaging to improve the accuracy and detection rate for population screening. The second major area of investigation uses computers to construct sophisticated mathematical models of individual cancer cells as well as larger systems using partial differential equations. These models are further refined with clinically available information to more accurately reflect living systems. One of the major obstacles in the partnership between physical scientists and the oncology community is communications. Standard ways to convey information must be developed. Future progress in computational oncology will depend on close collaboration between clinicians and investigators to further the understanding of cancer using these new approaches.
authors: Jichi Medical University, Yakushiji 3311-1 Shimotsuke City, Tochigi 329-0498, Japan. alefor@jichi.ac.jp
authors: Alan T
authors: AT
authors: Lefor
mesh_terms: D019295:Computational Biology; D003198:Computer Simulation; D023281:Genomics; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008433:Mathematics; D008495:Medical Oncology; D008954:Models, Biological; D010825:Physics; D040901:Proteomics