title: Accumulation levels and characteristics of some pesticides in human adipose tissue samples from Southeast China.
abstract: This paper presents a comprehensive study of pesticide levels and bio-accumulation characteristics in human adipose tissues among residents of Southeast China. A large number of adipose samples (n=633) were selected for 58 pesticides and were analyzed by high sensitive Gas Chromatography-Tandem Mass Spectrometry (GC-MS/MS). The results showed that POPs pesticides were frequently detected, including 2,4'-DDD, 2,4'-DDE, 2,4'-DDT, 4,4'-DDD, 4,4'-DDE, 4,4'-DDT, α-HCH, β-HCH, γ-HCH, δ-HCH, hexachlorobenzene (HCB), and mirex. Other detected pesticide species were dicofol, methamidophos and chlordimeform, which have rarely been reported. Comparing to different countries, the concentrations of total DDT and HCH in these three Chinese southeastern sites were in the middle range, whereas the HCB and mirex were in the lower end. A significant correlation was observed between region as well as age and POPs pesticide levels. Some pesticide residue levels were also found significantly correlated to occupation. However, there was no significant correlation between gender and pesticides. Meanwhile, it is interesting to find that mortality of malignant tumors tends to associate with the pesticides levels in human adipose tissue. More importantly, the measured data presented in this study provide realistic information which is useful for assessing human exposure to pesticides in the general population of Southeast China.
authors: Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing 210042, China.
authors: Na
authors: N
authors: Wang
authors: Lili
authors: L
authors: Shi
authors: Deyang
authors: D
authors: Kong
authors: Daoji
authors: D
authors: Cai
authors: Yanzhong
authors: Y
authors: Cao
authors: Yongming
authors: Y
authors: Liu
authors: Guofang
authors: G
authors: Pang
authors: Rongbin
authors: R
authors: Yu
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D003634:DDT / Q000378:metabolism; D003633:Dichlorodiphenyl Dichloroethylene / Q000378:metabolism; D003632:Dichlorodiphenyldichloroethane / Q000378:metabolism; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D004785:Environmental Pollutants / Q000378:metabolism*; D005260:Female; D006581:Hexachlorobenzene / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010575:Pesticides / Q000378:metabolism*; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D010575:Pesticides; C086916:delta-hexachlorocyclohexane; D003633:Dichlorodiphenyl Dichloroethylene; D006581:Hexachlorobenzene; D001556:Hexachlorocyclohexane; D003634:DDT; C016340:o,p'-DDT; D003632:Dichlorodiphenyldichloroethane; C023888:beta-hexachlorocyclohexane