title: Cell signaling and receptors with resorcinols and flavonoids: redox, reactive oxygen species, and physiological effects.
abstract: There have been appreciable numbers of reviews on monophenols, catechols, and hydroquinones. However, the resorcinol class has received less attention. This review deals with resorcinols and flavonoids. Emphasis is on cell signaling in addition to antioxidant (AO) properties and pro-oxidant effects. The apparent dichotomy is rationalized. There is extensive literature dealing with various aspects of cell signaling in addition to receptor involvement. The physiological responses are provided along with integration into the unifying mechanistic theme of electron transfer (ET)-reactive oxygen species (ROS)-oxidative stress (OS). The multifaceted approach involving redox processes and cell signaling is unique in providing novel insight.
authors: Department of Chemistry and Biochemistry, San Diego State University, CA, USA. pkovacic@sundown.sdsu.edu
authors: Peter
authors: P
authors: Kovacic
authors: Ratnasamy
authors: R
authors: Somanathan
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D016877:Oxidants / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012118:Resorcinols / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D016877:Oxidants; D017382:Reactive Oxygen Species; D012118:Resorcinols