title: Sleep correlates of cognition in early course psychotic disorders.
abstract: BACKGROUND
  Slow waves and sleep spindles, the main oscillations during non-rapid eye movement sleep, have been thought to be related to cognitive processes, and are impaired in psychotic disorders. Cognitive impairments, seen early in the course of psychotic disorders, may be related to alterations in these oscillations, but few studies have examined this relationship.
  
  
  METHODS
  Twenty seven untreated patients with a recently diagnosed psychotic disorder had polysomnographic sleep studies and neuro-cognitive testing.
  
  
  RESULTS
  Reduced power in the sigma range, which reflects spindle density, was associated with impaired attention, and reasoning, but not intelligence quotient (IQ). Slow wave sleep measures were not significantly associated with any cognitive measures.
  
  
  CONCLUSIONS
  Impairments in sleep spindles may be associated with cognitive deficits in the early course of psychotic disorders. These observations may help clarify neuro-biologic mechanisms of cognitive deficits in psychotic disorders such as schizophrenia.
authors: University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. mkeshava@bidmc.harvard.edu
authors: Matcheri S
authors: MS
authors: Keshavan
authors: Debra M
authors: DM
authors: Montrose
authors: Jean M
authors: JM
authors: Miewald
authors: Ripu D
authors: RD
authors: Jindal
mesh_terms: D000293:Adolescent; D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D017286:Polysomnography; D011618:Psychotic Disorders / Q000150:complications*; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000209:etiology*; D055815:Young Adult