title: Haemodynamic response to abdominal decompression in acute Budd-Chiari syndrome.
abstract: BACKGROUND
  Intra-abdominal hypertension (IAH) and abdominal compartment syndrome commonly occur in patients with liver disease.
  
  
  OBJECTIVE
  We compared haemodynamic variables pre- and post-abdominal decompression in patients with acute Budd-Chiari syndrome (BCS) and patients with chronic liver disease (CLD), ascites and IAH.
  
  
  METHODS
  Patients with IAH admitted to the Liver ICU, King's College Hospital were studied. Transpulmonary thermodilution cardiac output (CO) monitoring was performed with the PiCCO(®) system.
  
  
  RESULTS
  Ten patients with decompensated BCS (median age 39 years, 20-52) and eight patients with CLD (59 years, 33-65) and tense ascites requiring paracentesis were studied. Intra-abdominal pressure (IAP) was raised in both groups pre-intervention (BSC 23 mmHg, 17-40; CLD 26, 20-40). Intrathoracic blood volume (ITBVI) was persistently low in the BCS group (632 ml/m(2) , 453-924) despite volume resuscitation. Post-intervention, reduction in IAP was noted in both groups (BCS P<0.001, CLD P<0.0001). The ITBVI increased (P=0.001) in the BCS group only. An increase in cardiac index (CI) and stroke volume index (SVI) was noted in both groups (BCS: CI P=0.003, SVI: P=0.007; CLD: CI P=0.005, SVI P=0.02). The central venous pressure did not change in either group and did not correlate with markers of flow (CI, SVI) or IAP. Both groups demonstrated an inverse relationship between IAP, CI and SVI.
  
  
  CONCLUSIONS
  Patients with BCS and IAH have evidence of central hypovolaemia. In addition to raised IAP, hepatic venous obstruction and caudate lobe hypertrophy limit venous return in patients with BCS. Reduction in IAP and re-establishment of caval flow restores preload with improvement in CO.
authors: Dr D. Joshi Institute of Liver Studies, King's College Hospital, London, UK. d.joshi@nhs.net
authors: Deepak
authors: D
authors: Joshi
authors: Sujit
authors: S
authors: Saha
authors: William
authors: W
authors: Bernal
authors: Nigel
authors: N
authors: Heaton
authors: Julia
authors: J
authors: Wendon
authors: Georg
authors: G
authors: Auzinger
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001201:Ascites / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D001810:Blood Volume; D006502:Budd-Chiari Syndrome / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D002302:Cardiac Output; D002496:Central Venous Pressure; D019299:Decompression, Surgical; D058625:End Stage Liver Disease / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006439:Hemodynamics; D006801:Humans; D020896:Hypovolemia / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D059325:Intra-Abdominal Hypertension / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D016031:Liver Transplantation; D008131:London; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D019152:Paracentesis; D012189:Retrospective Studies; D013815:Thermodilution; D016896:Treatment Outcome; D014655:Vascular Resistance; D055815:Young Adult