title: Magnetic resonance spectroscopic imaging of benign prostatic tissue: findings at 3.0 T compared to 1.5 T-initial experience.
abstract: In a retrospective study of 71 voxels of benign peripheral zone tissue from 3 men who underwent endorectal magnetic resonance (MR) spectroscopic imaging of the prostate at both 1.5 and 3 T, 21 voxels that appeared more malignant at 3 T to either of two readers demonstrated significantly higher levels of choline and polyamines at 3 T compared to 1.5 T using a Wilcoxon ranked-sum test; awareness of this selective amplification of these metabolic signals at high field strength may help avoid overdiagnosis of prostate cancer.
authors: Department of Radiology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628, USA.
authors: Munish
authors: M
authors: Chitkara
authors: Antonio
authors: A
authors: Westphalen
authors: John
authors: J
authors: Kurhanewicz
authors: Aliya
authors: A
authors: Qayyum
authors: Liina
authors: L
authors: Poder
authors: Galen
authors: G
authors: Reed
authors: Fergus V
authors: FV
authors: Coakley
mesh_terms: D002794:Choline / Q000378:metabolism; D019343:Citric Acid / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011073:Polyamines / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D011073:Polyamines; D019343:Citric Acid; D003401:Creatine; D002794:Choline