title: Treatment of acute diarrhea with Saccharomyces boulardii in infants.
abstract: OBJECTIVE
  The aim of the study was to determine whether an oral treatment with a commercial pharmaceutical product containing Saccharomyces boulardii would reduce the duration of diarrhea in infants with acute diarrhea.
  
  
  METHODS
  In the present double-blind, placebo-controlled study, 186 infants, 6 to 48 months old and hospitalized within 72 hours after the onset of acute diarrhea in 2 hospitals in Goiânia, Goiás, Brazil, were randomly assigned to receive twice per day for 5 days 200 mg of a commercial pharmaceutical product containing 4 × 10 viable cells of S boulardii or a placebo. Stool samples were submitted to search for rotavirus. Among the 176 infants who completed the trial, those treated with S boulardii (90) showed a reduction in diarrhea duration (P < 0.05) when compared with the placebo group (86).
  
  
  RESULTS
  The present study shows a reduction in diarrhea duration when S boulardii was given to children within 72 hours after the onset of acute diarrhea.
  
  
  CONCLUSIONS
  The present study suggests a complementary treatment of acute diarrhea in infants with daily oral doses of S boulardii.
authors: Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors: Naflesia B O
authors: NB
authors: Corrêa
authors: Francisco J
authors: FJ
authors: Penna
authors: Fátima M L S
authors: FM
authors: Lima
authors: Jacques R
authors: JR
authors: Nicoli
authors: Luciano A P
authors: LA
authors: Filho
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D001938:Brazil; D002675:Child, Preschool; D003967:Diarrhea / Q000628:therapy*; D004311:Double-Blind Method; D005243:Feces / Q000737:chemistry / Q000821:virology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D019936:Probiotics / Q000008:administration & dosage*; D012401:Rotavirus / Q000302:isolation & purification; D012440:Saccharomyces