title: Epilepsy surgery in children with developmental tumours.
abstract: We report our experience regarding evaluation, surgical treatment and outcomes in a population of 21 children with histopathologically confirmed developmental tumours [nine dysembryoplastic neuroepithelial tumours (DNET), ten gangliogliomas (GG) and two gangliocytomas (GC)] and related epilepsy, analyzing video-EEG, MRI and neuropsychological data, before and after surgery. Most children had focal epilepsy correlating well with lesion location. One patient had epileptic spasms and generalized discharges. Tumours were located in the temporal lobe in 13 patients. Mean age at surgery was 11.16 years. Postsurgical MRI showed residual tumour growth in one DNET. One child had a recurrent ganglioglioma with anaplastic transformation. At latest follow-up (mean 4.68 years) 95.2% of patients were seizure-free and no significant neuropsychological declines were observed. Evidence from our study suggests that, in this setting, surgery should be performed before criteria for refractory epilepsy are met, particularly in cases with early seizure onset, in order to optimize cognitive outcome.
authors: Epilepsy Monitoring Unit, Neurophysiology Section, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. martagf@hotmail.com
authors: Marta
authors: M
authors: García-Fernández
authors: Concepción
authors: C
authors: Fournier-Del Castillo
authors: Arturo
authors: A
authors: Ugalde-Canitrot
authors: Ángeles
authors: Á
authors: Pérez-Jiménez
authors: Juan
authors: J
authors: Álvarez-Linera
authors: Inmaculada
authors: I
authors: De Prada-Vicente
authors: Jesús
authors: J
authors: Suárez-Rodríguez
authors: Jordi
authors: J
authors: Bernabeu-Verdú
authors: Francisco
authors: F
authors: Villarejo-Ortega
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D018303:Ganglioglioma / Q000473:pathology / Q000601:surgery*; D005729:Ganglioneuroma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000601:surgery*; D012189:Retrospective Studies; D055815:Young Adult