title: A novel alkali metals/strontium co-substituted calcium polyphosphate scaffolds in bone tissue engineering.
abstract: Our purpose of this study is to develop potassium or sodium/strontium co-substituted calcium polyphosphate (K/Sr-CPP or Na/Sr-CPP) bioceramics in application of bone repairing scaffold. The incorporation of K, Na, and Sr into CPP substrate via a calcining-sintering process was confirmed by X-ray diffractometry and inductively coupled plasma atomic emission spectroscopy. In vitro degradation study of co-substituted CPP indicated the incorporation of alkali metal elements promoted the degradability of CPP, and the scanning electron microscope showed the apatite-like minerals were precipitated on the surface of co-substituted CPP. The compress resistant strength of co-substituted CPP was elevated by dopants. The MTT assay and confocal laser-scanning microscope on osteoblasts culturing with co-substituted CPP showed no cytotoxicity. The cell proliferation on co-substituted CPP was even better than others. Thus, this co-substituted CPP bioceramics might have potential of applications in orthopedic field.
authors: Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, USA.
authors: Wei
authors: W
authors: Song
authors: Qiguang
authors: Q
authors: Wang
authors: Changxiu
authors: C
authors: Wan
authors: Tong
authors: T
authors: Shi
authors: David
authors: D
authors: Markel
authors: Ralph
authors: R
authors: Blaiser
authors: Weiping
authors: W
authors: Ren
mesh_terms: D000818:Animals; D018786:Bone Substitutes; D001842:Bone and Bones / Q000601:surgery; D002130:Calcium Phosphates / Q000494:pharmacology / Q000627:therapeutic use; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D008422:Materials Testing; D008672:Metals, Alkali; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects; D013324:Strontium; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D008672:Metals, Alkali; D013324:Strontium