title: Direct activation of guinea pig vagal afferent neurons by FMRFamide.
abstract: Vagus nerve comprises two distinct kinds of nerves, nodose and jugular ganglionic nerves. We tested pharmacological difference between two vagal nerves in the responsiveness to FMRFamide. The response probability to FMRFamide was significantly higher in nodose than jugular nerves in intracellular calcium measurement. Nodose nerves also depolarized membrane potential to FMRFamide more than jugular nerves did, in patch-clamp recording, although the probability of action potential discharge was same in both nerves. The inward current induced by FMRFamide was characterized as mixed cations. These results suggest that FMRFamide may act as an activator and modulator of vagal sensory nerves for treating symptoms in visceral diseases.
authors: Department of Physiology, Korea University College of Medicine, Seoul, Republic of Korea. mingoolee@korea.ac.kr
authors: Min-Goo
authors: MG
authors: Lee
authors: Ji-Yong
authors: JY
authors: Park
authors: Young Keun
authors: YK
authors: Park
authors: Bradley J
authors: BJ
authors: Undem
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D019835:FMRFamide / Q000494:pharmacology*; D006168:Guinea Pigs; D049990:Membrane Transport Modulators / Q000494:pharmacology*; D009475:Neurons, Afferent / Q000187:drug effects*; D009620:Nodose Ganglion / Q000187:drug effects*; D018408:Patch-Clamp Techniques; D014630:Vagus Nerve / Q000187:drug effects
chemical_list: D049990:Membrane Transport Modulators; D019835:FMRFamide