title: Osteopontin: a potentially important therapeutic target in cancer.
abstract: BACKGROUND
  Cancer is an extremely complex disease and most cancer treatments are limited to chemotherapy, radiation and surgery. The progression of tumours towards malignancy requires the interaction of various cytokines, growth factors, transcription factors and effector molecules. Osteopontin is a cytokine-like, calcium-binding, extracelular-matrix- associated member of the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. It plays an important role in determining the oncogenic potential of various cancers. The role of osteopontin in various pathophysiological conditions suggests that the alteration in post-translational modification result in different functional forms that might change its normal physiological functions.
  
  
  METHODS
  Osteopontin -based anticancer therapy, which may provide a new insight for the effective management of cancer.
  
  
  CONCLUSIONS
  A better understanding of the signalling mechanism by which osteopontin promotes tumourigenesis may be useful in crafting novel osteopontin -based anticancer therapy. The role of osteopontin in promoting cancer progression is the subject of in depth investigation and thus targeting osteopontin might be a suitable therapeutic approach for the treatment of cancer.
authors: National Center for Cell Science , NCCS Complex, Ganeshkhind, Pune, India.
authors: Mansoor
authors: M
authors: Ahmed
authors: Reeti
authors: R
authors: Behera
authors: Goutam
authors: G
authors: Chakraborty
authors: Shalini
authors: S
authors: Jain
authors: Vinit
authors: V
authors: Kumar
authors: Priyanka
authors: P
authors: Sharma
authors: Anuradha
authors: A
authors: Bulbule
authors: Smita
authors: S
authors: Kale
authors: Santosh
authors: S
authors: Kumar
authors: Rosalin
authors: R
authors: Mishra
authors: Remya
authors: R
authors: Raja
authors: Supriya
authors: S
authors: Saraswati
authors: Rajinder
authors: R
authors: Kaur
authors: Gowrishankar
authors: G
authors: Soundararajan
authors: Dhiraj
authors: D
authors: Kumar
authors: Dhanashri
authors: D
authors: Thorat
authors: Megha
authors: M
authors: Sanyal
authors: Anuja
authors: A
authors: Ramdasi
authors: Pompom
authors: P
authors: Ghosh
authors: Gopal C
authors: GC
authors: Kundu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018450:Disease Progression; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D053495:Osteopontin / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
chemical_list: D000970:Antineoplastic Agents; D053495:Osteopontin