title: Visual attention and autistic behavior in infants with fragile X syndrome.
abstract: Aberrant attention is a core feature of fragile X syndrome (FXS), however, little is known regarding the developmental trajectory and underlying physiological processes of attention deficits in FXS. Atypical visual attention is an early emerging and robust indictor of autism in idiopathic (non-FXS) autism. Using a biobehavioral approach with gaze direction and heart activity, we examined visual attention in infants with FXS at 9, 12, and 18 months of age with a cross-sectional comparison to 12-month-old typically developing infants. Analyses revealed lower HR variability, shallower HR decelerations, and prolonged look durations in 12-month old infants with FXS compared to typical controls. Look duration and increased latency to disengage attention were correlated with severity of autistic behavior but not mental age.
authors: FPG Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA. jane.roberts@sc.edu
authors: Jane E
authors: JE
authors: Roberts
authors: Deborah D
authors: DD
authors: Hatton
authors: Anna C J
authors: AC
authors: Long
authors: Vittoria
authors: V
authors: Anello
authors: John
authors: J
authors: Colombo
mesh_terms: D001288:Attention / Q000502:physiology*; D001321:Autistic Disorder / Q000150:complications / Q000523:psychology*; D002657:Child Development / Q000502:physiology*; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005600:Fragile X Syndrome / Q000150:complications / Q000523:psychology*; D006801:Humans; D007223:Infant; D008297:Male; D010988:Play and Playthings; D014796:Visual Perception / Q000502:physiology*