title: [Prenatal treatment of neonatal hemochromatosis with maternal administration of intravenous immunoglobulins (about four cases)].
abstract: OBJECTIVE
  Neonatal hemochromatosis is a very bad prognosis disease; liver transplantation was the only way to avoid an unfavourable evolution. Nowadays, hypothesis of an alloimmune mechanism for this disease has purposed to administrate high doses of immunoglobulins.
  
  
  METHODS
  In this study, we report four cases of women whose previous child had neonatal hemochromatosis and who received such a treatment during the next pregnancy from 18 weeks to the term.
  
  
  RESULTS
  This treatment allowed to lead their pregnancy to success. At birth, all four neonates were alive. Two of them presented transitory biologic symptoms of liver deficiency. All had a favourable evolution later.
  
  
  CONCLUSIONS
  Maternal treatment with high doses of immunoglobulins during pregnancy seems to improve dramatically the prognosis of neonatal hemochromatosis as it has been already reported. It could also apply to other diseases, which proceed from the same mechanism.
authors: Département de gynécologie-obstétrique et médecine néonatale, hôpital Poissy-Saint-Germain, université Versailles-Saint-Quentin, 10 rue du Champ-Gaillard, Poissy cedex, France. apaupe@chi-poissy-st-germain.fr
authors: A
authors: A
authors: Paupe
authors: B
authors: B
authors: Duclos
authors: B
authors: B
authors: Leroy
authors: M
authors: M
authors: Molho
mesh_terms: D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000517:prevention & control*; D006432:Hemochromatosis / Q000188:drug therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors