title: Comparison and correlation of Simple Sequence Repeats distribution in genomes of Brucella species.
abstract: Computational genomics is one of the important tools to understand the distribution of closely related genomes including simple sequence repeats (SSRs) in an organism, which gives valuable information regarding genetic variations. The central objective of the present study was to screen the SSRs distributed in coding and non-coding regions among different human Brucella species which are involved in a range of pathological disorders. Computational analysis of the SSRs in the Brucella indicates few deviations from expected random models. Statistical analysis also reveals that tri-nucleotide SSRs are overrepresented and tetranucleotide SSRs underrepresented in Brucella genomes. From the data, it can be suggested that over expressed tri-nucleotide SSRs in genomic and coding regions might be responsible in the generation of functional variation of proteins expressed which in turn may lead to different pathogenicity, virulence determinants, stress response genes, transcription regulators and host adaptation proteins of Brucella genomes.
  
  
  BACKGROUND
  SSRs - Simple Sequence Repeats, ORFs - Open Reading Frames.
authors: Division of Animal Biotechnology, Department of Zoology, S. V. University, Tirupati-517502, Andhra Pradesh, India.
authors: Jangampalli Adi Pradeep
authors: JA
authors: Kiran
authors: Veeraraghavulu Praveen
authors: VP
authors: Chakravarthi
authors: Yellapu Nanda
authors: YN
authors: Kumar
authors: Somesula Swapna
authors: SS
authors: Rekha
authors: Srinivasan Shanthi
authors: SS
authors: Kruti
authors: Matcha
authors: M
authors: Bhaskar