title: A comparative study on the efficacy of a commercial fibrin adhesive (Tisseel) vis-à-vis silk suture on wound closure following periodontal surgical procedures.
abstract: OBJECTIVE
  To evaluate the efficacy of fibrin adhesive sealant (Tisseel(®)), a human biological tissue adhesive, as compared to conventional suture placement in pocket elimination and mucogingival surgical procedures.
  
  
  METHODS
  The study sample consisted of 25 patients (10 male and 15 female patients), in the age group of 25-40 years, with localized periodontitis in relation to the anterior region of the maxilla and mandible. They were divided into three surgical groups: Group I, Group II and Group III. Each of these groups was further divided into control and experimental groups. In all the control groups, the flaps/grafts were approximated with 4-0 black braided silk. In the experimental groups, the flaps/grafts were approximated with fibrin adhesive sealant (Tisseel(;)). Clinical parameters were taken pre-operatively.operatively and post-operatively on the 1(st), 2(nd), 3(rd), 7(th), and 10(th), day.
  
  
  RESULTS
  The Fibrin Adhesive System (FAS) showed superior results in all the parameters measured, i.e., hemostasis, fixation of tissues, reduction in plaque and gingival index and probing depth postoperatively.
  
  
  CONCLUSIONS
  The results of this study indicate that periodontal surgery using FAS enhances various periodontal regenerative surgical procedures.
authors: Department of Periodontology & Implantology, Priyadarshini Dental College, Pandur, Thiruvallur District, Tamil Nadu, India.
authors: A G
authors: AG
authors: Manimegalai