title: Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome.
abstract: OBJECTIVE
  This study examined the possible association of G241R and K469E single nucleotide polymorphisms (SNPs) of ICAM-1 gene with the occurrence and clinical/biochemical characteristics of polycystic ovary syndrome (PCOS).
  
  
  METHODS
  G241R and K469E SNPs in DNA from peripheral blood leukocytes of 169 PCOS and 259 healthy control women were investigated by real-time PCR combined with melting curve analysis using fluorescence-labeled hybridization probes.
  
  
  RESULTS
  We did not find significant differences in the distributions of G241R and K469E polymorphisms, nor in the haplotype frequencies between PCOS and control women. None of the studied polymorphisms were found to affect insulin resistance indices significantly.
  
  
  CONCLUSIONS
  These preliminary results suggest that the 241 and 469 SNPs of ICAM-1 gene may not be risk factors for PCOS. Further studies with a larger cohort, analyzing other ICAM-1 polymorphisms are necessary to support our observations before any statement can be made about the relationship between PCOS and ICAM-1 polymorphisms.
authors: Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, Istanbul, Turkey. pervinvural@yahoo.com
authors: Pervin
authors: P
authors: Vural
authors: Müge
authors: M
authors: Kanmaz-Özer
authors: Semra
authors: S
authors: Doğru-Abbasoğlu
authors: Ali
authors: A
authors: Gedikbaşı
authors: Esra
authors: E
authors: Cil
authors: Berrin
authors: B
authors: Karadağ
authors: Müjdat
authors: M
authors: Uysal
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D018799:Intercellular Adhesion Molecule-1