title: Crotoxin and phospholipases A₂ from Crotalus durissus terrificus showed antiviral activity against dengue and yellow fever viruses.
abstract: Dengue is the most important arbovirus in the world with an estimated of 50 million dengue infections occurring annually and approximately 2.5 billion people living in dengue endemic countries. Yellow fever is a viral hemorrhagic fever with high mortality that is transmitted by mosquitoes. Effective vaccines against yellow fever have been available for almost 70 years and are responsible for a significant reduction of occurrences of the disease worldwide; however, approximately 200,000 cases of yellow fever still occur annually, principally in Africa. Therefore, it is a public health priority to develop antiviral agents for treatment of these virus infections. Crotalus durissus terrificus snake, a South American rattlesnake, presents venom with several biologically actives molecules. In this study, we evaluated the antiviral activity of crude venom and isolated toxins from Crotalus durissus terrificus and found that phospholipases A₂ showed a high inhibition of Yellow fever and dengue viruses in VERO E6 cells.
authors: Laboratório de Virologia, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café S/N, CEP 14040-903, Brazil.
authors: Vanessa Danielle Menjon
authors: VD
authors: Muller
authors: Raquel Rinaldi
authors: RR
authors: Russo
authors: Adelia Cristina Oliveira
authors: AC
authors: Cintra
authors: Marco Aurélio
authors: MA
authors: Sartim
authors: Raquel De Melo
authors: Rde M
authors: Alves-Paiva
authors: Luiz Tadeu Moraes
authors: LT
authors: Figueiredo
authors: Suely Vilela
authors: SV
authors: Sampaio
authors: Victor Hugo
authors: VH
authors: Aquino
mesh_terms: D000349:Africa; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003435:Crotalid Venoms / Q000302:isolation & purification / Q000494:pharmacology*; D017839:Crotalus; D003439:Crotoxin / Q000494:pharmacology*; D003716:Dengue Virus / Q000187:drug effects*; D054467:Phospholipases A2 / Q000494:pharmacology*; D014709:Vero Cells; D015005:Yellow fever virus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D003435:Crotalid Venoms; D003439:Crotoxin; D054467:Phospholipases A2