title: Multi-talented MCAK: Microtubule depolymerizer with a strong grip.
abstract: Microtubule-depolymerizing motor proteins regulate microtubule dynamics during chromosome segregation, but whether they can independently grip the ends of shrinking kinetochore microtubules has remained unresolved. MCAK, a member of the kinesin-13 motor protein family, is now shown to grip microtubules on its own and harness the forces of microtubule disassembly.
authors: Stefan
authors: S
authors: Diez
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology*; D020090:Chromosome Segregation; D006801:Humans; D016547:Kinesins / Q000235:genetics / Q000378:metabolism*; D007700:Kinetics; D018386:Kinetochores / Q000201:enzymology*; D040542:Mechanotransduction, Cellular; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis; D008954:Models, Biological; D058105:Polymerization; D013314:Stress, Mechanical; D014404:Tubulin / Q000378:metabolism*
chemical_list: C091489:KIF2C protein, human; D014404:Tubulin; D000255:Adenosine Triphosphate; D016547:Kinesins