title: Psychological impact of thrombophilia testing in asymptomatic family members.
abstract: BACKGROUND
  Psychological distress and worry are commonly described as potential consequences of genetic screening for various disorders. Thrombophilia testing may be offered to asymptomatic persons with a family history of venous thrombosis and thrombophilia. Our objectives were to measure the psychological impacts of thrombophilia testing in first degree relatives and to determine if our intervention, a more intensive care strategy to heighten awareness of both risk and symptoms of thrombosis, caused psychological distress.
  
  
  METHODS
  First degree relatives of patients with a known thrombophilia and history of venous thrombosis were tested for thrombophilia. The Perceived Risk Questionnaire and validated psychological instruments (POMS-SF; SCL-90-R Somatization subscale) were administered before testing, one week after receiving results and a year later. Thrombophilia carriers were randomized in family clusters to receive Standard Care or the Intensive Care intervention.
  
  
  RESULTS
  There were 100 carriers who were randomized to Standard (n=48) or Intensive Care (n=52) and 103 non-carriers. One week after receiving results, we did not observe any difference in psychological distress between carriers and non-carriers, with low levels overall. At 1 year, psychological distress scores were similar between the Standard and Intensive Care arms and did not differ from baseline.
  
  
  CONCLUSIONS
  The results of this pilot study do not support the concern that thrombophilia screening in asymptomatic relatives triggers psychological distress and worry. Furthermore, our intensive educational approach did not appear to induce undue distress. While the positive benefits of thrombophilia screening remain unproven, clinicians should not be deterred from offering screening by the fear of causing psychological harm.
authors: University of Western Ontario, London, Ontario, Canada.
authors: Martha L
authors: ML
authors: Louzada
authors: Monica
authors: M
authors: Taljaard
authors: Nicole J
authors: NJ
authors: Langlois
authors: Susan R
authors: SR
authors: Kahn
authors: Marc A
authors: MA
authors: Rodger
authors: David R
authors: DR
authors: Anderson
authors: Michael J
authors: MJ
authors: Kovacs
authors: Philip S
authors: PS
authors: Wells
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D019851:Thrombophilia / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology*; D020246:Venous Thrombosis / Q000235:genetics; D055815:Young Adult