title: Stereocontrolled synthesis of oligonucleotide analogs containing chiral internucleotidic phosphorus atoms.
abstract: Oligonucleotides, in which one of the two nonbridging oxygen atoms of internucleotidic phosphates is replaced by a different type of atom or a substituent, are useful as therapeutic agents and probes to elucidate mechanisms of enzymatic reactions. The internucleotidic phosphorus atoms of these oligonucleotides are chiral, and the properties of these oligonucleotides are affected by the absolute configuration of the chiral phosphorus atoms. In order to address the issue of chirality, various methods have been developed to synthesize these P-chiral oligonucleotide analogs in a stereocontrolled manner. This critical review focuses on the recent progress in this field (123 references).
authors: Department of Chemistry, Faculty of Engineering, Gifu University, Gifu 501-1193, Japan.
authors: Natsuhisa
authors: N
authors: Oka
authors: Takeshi
authors: T
authors: Wada
mesh_terms: D001483:Base Sequence; D002845:Chromatography; D004798:Enzymes / Q000378:metabolism; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification; D010758:Phosphorus / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D004798:Enzymes; D009841:Oligonucleotides; D010758:Phosphorus