title: Clinical profile, intensive care unit course, and outcome of patients admitted in intensive care unit with dengue.
abstract: OBJECTIVE
  The purpose of the study was to assess the clinical profile and course of dengue patients admitted to the intensive care unit (ICU) and to identify factors related to poor outcome.
  
  
  METHODS
  All patients with dengue admitted to ICU over 2.5 years were included prospectively. Severity of illness was assessed by the Acute Physiology and Chronic Health Evaluation (APACHE) II score, and organ failure was determined by the Sequential Organ Failure Assessment score. Primary outcome measure was 28-day mortality. Logistic regression analysis was performed to identify factors predicting mortality.
  
  
  RESULTS
  Data from 198 patients were analyzed. Mean age was 39.56 ± 17.1 years, and 61.1% were male. The commonest complaints were fever (96%) and rash (37.9%). Mean admission APACHE II and Sequential Organ Failure Assessment scores were 7.52 ± 7.8 and 4.52 ± 3.4, respectively. The commonest organ failure was coagulation (43.4%) followed by respiratory failure (13.1%). Vasopressors were required by 11.6%; and dialysis and mechanical ventilation were required by 7.6% and 9.1%, respectively. Mortality was 12 (6.1%); and on multivariate analysis, APACHE II score (odds ratio, 1.781; 95% confidence interval, 0.967-3.281; P = .048) could independently predict mortality.
  
  
  CONCLUSIONS
  Patients with dengue fever may require ICU admission for organ failure. Outcome is good if appropriate aggressive care and organ support are instituted. Admission APACHE II score may predict patients at higher risk of death.
authors: Department of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi-110017, India. Electronic address: devenjuneja@gmail.com.
authors: Deven
authors: D
authors: Juneja
authors: Department of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi-110017, India.
authors: Prashant
authors: P
authors: Nasa
authors: Department of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi-110017, India.
authors: Omender
authors: O
authors: Singh
authors: Department of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi-110017, India.
authors: Yash
authors: Y
authors: Javeri
authors: Department of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi-110017, India.
authors: Bhupesh
authors: B
authors: Uniyal
authors: Department of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi-110017, India.
authors: Rohit
authors: R
authors: Dang
mesh_terms: D018806:APACHE; D000328:Adult; D003715:Dengue / Q000150:complications / Q000401:mortality / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D007194:India / Q000453:epidemiology; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000401:mortality / Q000628:therapy / Q000821:virology*; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult