title: The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.
abstract: Regulation of cellular redox balances is important for the homeostasis of human health. Thus, many important human diseases, such as inflammation, diabetes, glaucoma, cancers, ischemia and neurodegenerative diseases, have been investigated in the field of reactive oxygen species (ROS) and oxidative stress. To overcome the harmful effect of oxidative stress and ROS, one can directly eliminate them by medical gases such as carbon monoxide (CO), hydrogen sulphide (H(2)S), and molecular hydrogen (H(2)), or one can induce ROS-resistant proteins and antioxidant enzymes to antagonize oxidative stresses. This article reviews the molecular mechanisms how these medical gasses work as antioxidants, and how ROS resistant proteins are produced in the physiological context. Targeted therapeutic modalities to scavenge or prevent ROS might be applied in the prevention and treatment of ROS-related diseases in the near future.
authors: Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan. noda@phar.kyushu-u.ac.jp
authors: Mami
authors: M
authors: Noda
authors: Kyota
authors: K
authors: Fujita
authors: Chih-Hung
authors: CH
authors: Lee
authors: Tohru
authors: T
authors: Yoshioka
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D002248:Carbon Monoxide / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D019610:Cytoprotection / Q000187:drug effects*; D006801:Humans; D006859:Hydrogen / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D006862:Hydrogen Sulfide / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D008954:Models, Biological; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism*; D035703:Therapies, Investigational / Q000379:methods*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D002248:Carbon Monoxide; D006859:Hydrogen; D006862:Hydrogen Sulfide