title: Clinical profile of leukocyte adhesion deficiency type I.
abstract: Leukocyte adhesion deficiency type I (LAD-I) is a rare, inherited immunodeficiency with defect in the recruitment of leukocyte to the site of inflammation.  Patients with severe LAD-I have absent or markedly reduced expression of CD18 and CD11. Here we report clinical profile of 7 cases of LAD-I diagnosed at our center over a period of 3 years.  Recurrent skin and mucous membrane infections were the major presenting manifestations.  All children had a history of delayed cord separation.
authors: Department of Paediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), KEM Hospital, Parel, Mumbai, India. madkaikarmanisha@yahoo.co.in
authors: M
authors: M
authors: Madkaikar
authors: Z
authors: Z
authors: Currimbhoy
authors: M
authors: M
authors: Gupta
authors: M
authors: M
authors: Desai
authors: M
authors: M
authors: Rao
mesh_terms: D001772:Blood Cell Count; D018845:CD11 Antigens / Q000032:analysis*; D018821:CD18 Antigens / Q000032:analysis*; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D008297:Male
chemical_list: D018845:CD11 Antigens; D018821:CD18 Antigens