title: Pragmatic management of Panton-Valentine leukocidin-associated staphylococcal diseases.
abstract: Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus is associated with a broad spectrum of diseases, ranging from common uncomplicated soft tissue infections to severe diseases such as complicated soft tissue infections, extensive bone and joint infections, and necrotising pneumonia. Specialised management of infection based on the presence of PVL may not be required for mild infections, whereas it could be lifesaving in other settings. Moreover, most severe PVL diseases are recently identified entities and a 'gold standard' treatment from comparatives studies of different therapeutic options is lacking. Thus, recommendations are based on expert opinions, which are elaborated based on theory, in vitro data and analogies with other toxin-mediated diseases. In this review, we consider the potential need for specialised PVL-based management and, if required, which tools should be used to achieve optimal management.
authors: Division of Pediatric Intensive Care, Hôpital Femme Mère Enfant, Bron, France.
authors: Y
authors: Y
authors: Gillet
authors: O
authors: O
authors: Dumitrescu
authors: A
authors: A
authors: Tristan
authors: O
authors: O
authors: Dauwalder
authors: E
authors: E
authors: Javouhey
authors: D
authors: D
authors: Floret
authors: F
authors: F
authors: Vandenesch
authors: J
authors: J
authors: Etienne
authors: G
authors: G
authors: Lina
mesh_terms: D001427:Bacterial Toxins / Q000378:metabolism*; D019468:Disease Management; D005098:Exotoxins / Q000378:metabolism*; D006801:Humans; D007956:Leukocidins / Q000378:metabolism*; D018461:Soft Tissue Infections / Q000382:microbiology / Q000628:therapy*; D013203:Staphylococcal Infections / Q000382:microbiology / Q000628:therapy*; D013207:Staphylococcal Skin Infections / Q000382:microbiology / Q000628:therapy*; D013211:Staphylococcus aureus / Q000472:pathogenicity*
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin