title: HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level.
abstract: HIV-1 crosses the blood-brain barrier (BBB) early in the course of systemic infection and resides in brain macrophages and microglia. The integrity of the brain endothelium is regulated by intercellular tight junctions, which also play a critical role in HIV-1-entry into the brain. Disruption of tight junctions, including changes in claudin-5 expression, is common in HIV-1-infected patients. Recent evidence indicates that both exposure to HIV-1 and HIV-1 specific proteins, such as Tat protein, can contribute to alterations of expression and distribution of claudin-5 in brain endothelial cells and brain microvessels.
authors: Ibolya E
authors: IE
authors: András
authors: Michal
authors: M
authors: Toborek
mesh_terms: D001812:Blood-Brain Barrier / Q000378:metabolism* / Q000821:virology; D015153:Blotting, Western / Q000379:methods; D045744:Cell Line, Tumor; D062507:Claudin-5; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008856:Microscopy, Fluorescence / Q000379:methods; D019108:Tight Junctions / Q000378:metabolism* / Q000821:virology
chemical_list: C107466:CLDN5 protein, human; D062507:Claudin-5; D008565:Membrane Proteins