title: Cerenkov luminescence tomography for in vivo radiopharmaceutical imaging.
abstract: Cerenkov luminescence imaging (CLI) is a cost-effective molecular imaging tool for biomedical applications of radiotracers. The introduction of Cerenkov luminescence tomography (CLT) relative to planar CLI can be compared to the development of X-ray CT based on radiography. With CLT, quantitative and localized analysis of a radiopharmaceutical distribution becomes feasible. In this contribution, a feasibility study of in vivo radiopharmaceutical imaging in heterogeneous medium is presented. Coupled with a multimodal in vivo imaging system, this CLT reconstruction method allows precise anatomical registration of the positron probe in heterogeneous tissues and facilitates the more widespread application of radiotracers. Source distribution inside the small animal is obtained from CLT reconstruction. The experimental results demonstrated that CLT can be employed as an available in vivo tomographic imaging of charged particle emitters in a heterogeneous medium.
authors: Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors: Jianghong
authors: J
authors: Zhong
authors: Chenghu
authors: C
authors: Qin
authors: Xin
authors: X
authors: Yang
authors: Shuping
authors: S
authors: Zhu
authors: Xing
authors: X
authors: Zhang
authors: Jie
authors: J
authors: Tian