title: Isolation, characterisation and cytotoxicity study of arjunolic acid from Terminalia arjuna.
abstract: Arjunolic acid (AA), a triterpenoid, was isolated from the ethyl acetate and methanol extracts of Terminalia arjuna core wood. The purity of AA was analysed by its melting point, FT-IR and NMR spectroscopy analyses. In vitro cytotoxicity was assessed using Ehrlich ascites carcinoma (EAC) and Dalton's lymphoma (DAL) cell lines by incubating with different concentrations of AA. The cancer cell death percentage at 100 µg concentrations of AA ranged between 66% and 70% on the DAL and EAC cell lines, respectively. This infers that AA causes considerable membrane damage to cancer cells.
authors: SBST, Vellore Institute of Technology University, Vellore, Tamil Nadu, India.
authors: A Sai
authors: AS
authors: Ramesh
authors: J Godwin
authors: JG
authors: Christopher
authors: R
authors: R
authors: Radhika
authors: C R
authors: CR
authors: Setty
authors: V
authors: V
authors: Thankamani
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared; D029766:Terminalia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D014315:Triterpenes; C061640:arjunolic acid