title: Quantification of surface amorphous content using dispersive surface energy: the concept of effective amorphous surface area.
abstract: We investigate the use of dispersive surface energy in quantifying surface amorphous content, and the concept of effective amorphous surface area is introduced. An equation is introduced employing the linear combination of surface area normalized square root dispersive surface energy terms. This equation is effective in generating calibration curves when crystalline and amorphous references are used. Inverse gas chromatography is used to generate dispersive surface energy values. Two systems are investigated, and in both cases surface energy data collected for physical mixture samples comprised of amorphous and crystalline references fits the predicted response with good accuracy. Surface amorphous content of processed lactose samples is quantified using the calibration curve, and interpreted within the context of effective amorphous surface area. Data for bulk amorphous content is also utilized to generate a thorough picture of how disorder is distributed throughout the particle. An approach to quantifying surface amorphous content using dispersive surface energy is presented. Quantification is achieved by equating results to an effective amorphous surface area based on reference crystalline, and amorphous materials.
authors: Physical Properties, Particle Generation, Engineering and Control, Product Development, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA. jeffrey.brum@gsk.com
authors: Jeffrey
authors: J
authors: Brum
authors: Daniel
authors: D
authors: Burnett
mesh_terms: D000465:Algorithms; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002849:Chromatography, Gas; D004339:Drug Compounding; D007785:Lactose / Q000737:chemistry*; D013499:Surface Properties; D013678:Technology, Pharmaceutical
chemical_list: D007785:Lactose