title: Claudin-16/paracellin-1, cloning, expression, and its role in tight junction functions in cancer and endothelial cells.
abstract: Metastatic spread of cancer is the major reason for patient mortality in human breast cancer. We examined expression of claudin-16 in human breast cells and tissues to identify a possible link between expression and aggressiveness in cells and between claudin-16 levels and patient prognosis. Forced expression of claudin-16 in breast cancer cells resulted in a less aggressive phenotype and reduced in vivo tumour volume. Claudin-16 expression was reduced in human breast cancer, particularly in patients with aggressive tumours and high mortality (Martin et al. J Cell Biochem 105:41-52,2008). This suggests that claudin-16 plays a role beyond that of an initial metastasis repressor in this cancer type.
authors: Metastasis & Angiogenesis Research Group, University Department of Surgery, Cardiff School of Medicine, Cardiff University, Cardiff, UK. Martinta1@cf.ac.uk
authors: Tracey A
authors: TA
authors: Martin
authors: Wen G
authors: WG
authors: Jiang
mesh_terms: D000818:Animals; D015153:Blotting, Western / Q000379:methods; D001943:Breast Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D057167:Claudins; D003001:Cloning, Molecular / Q000379:methods; D017931:DNA Primers / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D019108:Tight Junctions / Q000378:metabolism*
chemical_list: D057167:Claudins; D017931:DNA Primers; D008565:Membrane Proteins; C502010:claudin 16