title: Synthesis and cytotoxicity of the depsipeptides analogues of callipeltin B.
abstract: Solid phase synthesis of the cyclic depsipeptides of callipeltin B analogues and evaluation of cytotoxicity of synthetic peptides are described. We attempted to synthesize cyclic depsipeptides via the esterification or the amide bond formation for cyclization steps. In the assay of synthetic peptides, the linear peptide (10) exhibited modest cytotoxicity against HeLa cells.
authors: Department of Biochemical Engineering, Graduate School of Science and Technology, Yamagata University, Yonezawa, Yamagata 992-8510, Japan.
authors: Mari
authors: M
authors: Kikuchi
authors: Yoshihisa
authors: Y
authors: Watanabe
authors: Masaki
authors: M
authors: Tanaka
authors: Kenichi
authors: K
authors: Akaji
authors: Hiroyuki
authors: H
authors: Konno
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D003500:Cyclization; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D010456:Peptides, Cyclic; C516600:callipeltin B