title: Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India.
abstract: OBJECTIVE
  Severe anaemia in Plasmodium falciparum (Pf) associated malaria is a leading cause of death despite low levels of parasitaemia. In an effort to understand the pathogenesis of anaemia we studied expression level of RBC complement regulatory proteins, CR1 (CD35), CD55 and CD59 with haemoglobin status in a group of malaria cases from Assam, Goa and Chennai, and in healthy controls.
  
  
  METHODS
  Flowcytometry was used to study expression of CR1, CD55 and CD59 in 50 Pf cases and 30 normal healthy volunteers. Giemsa stained thick and thin blood films were used for microscopic detection and identification of malarial parasites and parasite count.
  
  
  RESULTS
  No correlation was found between degree of expression of RBC surface receptors CR1, CD55 and CD59 with haemoglobin level. However, expression of CD55 was less in malaria cases than in healthy controls.
  
  
  CONCLUSIONS
  The present findings indicate that malaria infection changes the expression profile of complement regulatory protein CD55 irrespective of severity status of anaemia. Further studies are needed to explore the pathophysiology of anaemia in malaria cases in Assam where expression of RBC complement receptors appears to be low even in normal healthy population.
authors: Department of Parasitology, Postgraduate Institute of Medical Education & Research, Chandigarh, India. indurc43@gmail.com
authors: R C
authors: RC
authors: Mahajan
authors: K
authors: K
authors: Narain
authors: J
authors: J
authors: Mahanta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000276:immunology* / Q000382:microbiology; D018958:CD55 Antigens / Q000276:immunology*; D018957:CD59 Antigens / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D016778:Malaria, Falciparum / Q000097:blood* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D017463:Receptors, Complement 3b / Q000276:immunology*; D055815:Young Adult
chemical_list: D018958:CD55 Antigens; D018957:CD59 Antigens; C509991:CR1 protein, human; D017463:Receptors, Complement 3b