title: The spectrum of nonadherence with medication in heart, liver, and lung transplant patients assessed in various ways.
abstract: Adherence to medication regimes is crucial for transplant patients. Addressing methodological limitations and gaps in the literature, we studied: (i) the prevalence of nonadherence (NA) with immunosuppression (IS) using various measurement methods, (ii) NA prevalence regarding intake and timing, (iii) changes in NA over time, (iv) differences in NA across organ transplant populations, (v) NA regarding co-medication. Using a descriptive, prospective, comparative design over 3 months, we included convenience samples of adult heart (n=79), liver (n=55), and lung (n=104) transplant patients. NA with IS was measured using self-report, collateral report, blood assay, electronic monitoring (Helping Hand™ , Bang and Olufsen Medicom, Denmark), and their combinations. In the overall sample, depending on the method used, IS NA ranged from 23.9% to 70.0%. For co-medication, the overall NA rate was 30.1% using self-report. Nonadherence rates remained stable over time. At inclusion, significant NA differences between organ groups were reported via self- and collateral report; lung transplant patients were less adherent than heart or liver transplant recipients, both to IS and to co-medication.
authors: Centre for Health Services and Nursing Research, Katholieke Universiteit Leuven, Kapucijnenvoer 35, Leuven, Belgium.
authors: Leentje
authors: L
authors: De Bleser
authors: Fabienne
authors: F
authors: Dobbels
authors: Lut
authors: L
authors: Berben
authors: Johan
authors: J
authors: Vanhaecke
authors: Geert
authors: G
authors: Verleden
authors: Frederik
authors: F
authors: Nevens
authors: Sabina
authors: S
authors: De Geest
mesh_terms: D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016031:Liver Transplantation; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012650:Self Disclosure; D016559:Tacrolimus / Q000008:administration & dosage / Q000097:blood; D016903:Drug Monitoring
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus