title: Fragment-based lead discovery: challenges and opportunities.
abstract: Fragment-based lead discovery has undergone remarkable changes over the last 15 years. During this time, the pharmaceutical industry has changed dramatically as well, and continued evolution of the industry is assured. These changes present many challenges but also several opportunities for executing fragment-based drug design. This article will explore some of the more significant changes in the industry and how they may affect future discovery efforts related to fragment-based initiatives.
authors: Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
authors: Chaohong
authors: C
authors: Sun
authors: Andrew M
authors: AM
authors: Petros
authors: Philip J
authors: PJ
authors: Hajduk
mesh_terms: D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D055808:Drug Discovery / Q000639:trends*; D004345:Drug Industry / Q000639:trends*; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010446:Peptide Fragments / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D008024:Ligands; D010446:Peptide Fragments; D011506:Proteins