title: Immunogenicity of conjugate meningococcus C vaccine in pediatric solid organ transplant recipients.
abstract: The present study was aimed to evaluate the immunogenicity of a single dose of conjugate Meningococcus C (Men C) vaccine by analyzing the serum bactericidal antibody (SBA) titers in 10 pediatric solid organ transplant (SOT) patients. Four patients showed a delayed immune response after 1 month, but all patients demonstrated an increase of SBA titers after vaccination. A significant decrease of SBA titers was seen after 6 months. However, all patients maintained protective SBA titers (≥1:8) despite rapidly waning titers. For patients with significantly decreasing titers, a booster dose may be discussed with close monitoring of SBA titers over time.
authors: Department of Pediatrics, Pediatrics I, Medical University Innsbruck, Innsbruck, Austria.
authors: Manuela
authors: M
authors: Zlamy
authors: Johannes
authors: J
authors: Elias
authors: Ulrich
authors: U
authors: Vogel
authors: Matthias
authors: M
authors: Frosch
authors: Verena
authors: V
authors: Jeller
authors: Gerard
authors: G
authors: Cortina
authors: Therese
authors: T
authors: Jungraithmayr
authors: Martina
authors: M
authors: Prelog
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008585:Meningitis, Meningococcal / Q000276:immunology / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use; D038542:Neisseria meningitidis, Serogroup C / Q000276:immunology; D016377:Organ Transplantation; D058248:Serum Bactericidal Antibody Assay; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022401:Meningococcal Vaccines; D018074:Vaccines, Conjugate