title: Synthesis and cell uptake of a novel dualmodality (188)Re-HGRGD (D) F-CdTe QDs probe.
abstract: A novel dualmodality probe was prepared by linking (188)Re-HGRGD (D) F with CdTe QDs, which was monitored using radio-thin layer chromatography (TLC) and -high performance liquid chromatography (HPLC). The (188)Re-HGRGD (D) F-CdTe QDs probe possesses a radiochemistry yield of 92.1% and strong photoluminescence (PL) stability. However, the radiochemical purity of (188)Re-HGRGD (D) F-QDs would reduce to 74.8%, which should be further improved, after incubation with newborn calf serum (NCF) for 24h. Human glioblastoma U87MG cells, known to express a high-affinity to RGD, were used to assess the in vitro cell binding of probe. The results showed that the radio-signal was in accord with the change of PL intensity, which meant the successful integration of (188)Re and QDs.
authors: Radiopharmaceutical Centre, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 2019 Jia Luo Road, Shanghai 201800, China.
authors: Zheng
authors: Z
authors: Li
authors: Guoxin
authors: G
authors: Zhang
authors: Hua
authors: H
authors: Shen
authors: Lan
authors: L
authors: Zhang
authors: Yongxian
authors: Y
authors: Wang
mesh_terms: D001692:Biological Transport; D019187:Cadmium Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism*; D045663:Quantum Dots; D011854:Radiochemistry; D011868:Radioisotopes; D012211:Rhenium / Q000737:chemistry* / Q000627:therapeutic use; D013691:Tellurium / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D009842:Oligopeptides; D011868:Radioisotopes; D012211:Rhenium; C047981:arginyl-glycyl-aspartic acid; D013691:Tellurium; C028337:cadmium telluride