title: Renal impairment and moderate alcohol consumption in the elderly. Results from the Italian Longitudinal Study on Aging (ILSA).
abstract: OBJECTIVE
  The influence of moderate alcohol consumption on renal function is not clear in elderly people. The aim of the present study was to investigate the relationship between alcohol consumption and renal function, expressed as serum creatinine levels and glomerular filtration rates (GFR), in an elderly population.
  
  
  METHODS
  Perspective cohort study.
  
  
  METHODS
  Population-based study on an elderly Italian population.
  
  
  METHODS
  A sample of 3404 Italian people (1619 women and 1785 men), aged 65-84 years, from the Italian Longitudinal Study on Aging (ILSA).
  
  
  RESULTS
  Prevalence and cumulative risk of impaired renal function (defined as GFR ≤ 60 ml/min) were estimated by sex and alcohol consumption groups. Logistic regression analysis adjusting for confounders (age, education, smoking, BMI and medications) and intermediate factors (blood cholesterol and fibrinogen, systolic hypertension and diabetes) showed that alcohol consumption level was not significantly related to the prevalence of mild renal impairment in elderly women. In men, both prevalence and incidence results seemed to suggest an inverse linear relationship between moderate alcohol consumption and the risk of mild renal impairment. A U-shaped association was shown for women at the incidence phase, suggesting a higher risk of developing renal impairment for women who drink more than 24 g alcohol/d.
  
  
  CONCLUSIONS
  Our results suggest that, in accordance with the recommendations on alcohol consumption in the elderly, moderate quantities of alcohol are not injurious to renal function in elderly men.
authors: Department of Environmental Medicine and Public Health, University of Padua, Via Loredan 18, 35128 Padua, Italy.
authors: Alessandra
authors: A
authors: Buja
authors: Emanuele
authors: E
authors: Scafato
authors: Bruno
authors: B
authors: Baggio
authors: Giuseppe
authors: G
authors: Sergi
authors: Stefania
authors: S
authors: Maggi
authors: Giuseppe
authors: G
authors: Rausa
authors: Angela
authors: A
authors: Basile
authors: Enzo
authors: E
authors: Manzato
authors: Silvia
authors: S
authors: Ghirini
authors: Egle
authors: E
authors: Perissinotto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects; D000428:Alcohol Drinking / Q000453:epidemiology*; D000434:Alcoholic Beverages; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000473:pathology; D015994:Incidence; D007407:Interviews as Topic; D007558:Italy / Q000453:epidemiology; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D015995:Prevalence; D051437:Renal Insufficiency / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology*; D012307:Risk Factors; D012907:Smoking; D011795:Surveys and Questionnaires
chemical_list: D005340:Fibrinogen; D002784:Cholesterol; D003404:Creatinine