title: Quercetin 3-rhamnoside exerts antiinfluenza A virus activity in mice.
abstract: Our previous report showed that quercetin 3-rhamnoside (Q3R) possessed antiviral activity against influenza A/WS/33 virus in vitro. The present study evaluated the effect of Q3R on influenza A/WS/33 virus infected mice. Mice orally treated with Q3R (6.25 mg/kg per dose) at 2 h before and once daily for 6 days after influenza virus infection showed significant decreases in weight loss, and decreased mortality. Lung virus titers of mice killed at 6 days after infection were about 2000 times lower than that of the placebo-treated control mice and about two times lower than that for the oseltamivir-treated mice. Furthermore, histological evaluation showed that administration of Q3R delayed the development and progression of pulmonary lesions. Therefore, Q3R could be an attractive lead for the development of antiviral agents against influenza virus.
authors: Department of Clinical Pathology, Daejeon Health Sciences College, 77-3 Gayang2-Dong, Dong-Gu, Daejeon 300-711, South Korea.
authors: Hwa Jung
authors: HJ
authors: Choi
authors: Jae Hyoung
authors: JH
authors: Song
authors: Dur Han
authors: DH
authors: Kwon
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002460:Cell Line; D004285:Dogs; D009980:Influenza A virus / Q000187:drug effects* / Q000472:pathogenicity; D008168:Lung / Q000473:pathology / Q000821:virology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000821:virology; D053139:Oseltamivir / Q000494:pharmacology; D008517:Phytotherapy; D011794:Quercetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D019562:Viral Load; D014776:Virus Cultivation / Q000379:methods; D015431:Weight Loss
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; D011794:Quercetin