title: Swinholide J, a potent cytotoxin from the marine sponge Theonella swinhoei.
abstract: In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC(50) value of 6 nM.
authors: Department of Chemistry of Natural Compounds, University of Naples, "Federico II", via D. Montesano 49, 80131 Napoli, Italy.
authors: Simona De
authors: S
authors: Marino
authors: Department of Chemistry of Natural Compounds, University of Naples, "Federico II", via D. Montesano 49, 80131 Napoli, Italy.
authors: Carmen
authors: C
authors: Festa
authors: Department of Chemistry of Natural Compounds, University of Naples, "Federico II", via D. Montesano 49, 80131 Napoli, Italy.
authors: Maria Valeria
authors: MV
authors: D'Auria
authors: Natural Substances Institute, la Terrasse Street, 91198 Gif sur Yvette Cedex, France.
authors: Thierry
authors: T
authors: Cresteil
authors: Polynesian Research Center on Island Biodiversity, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, French Polynesia, France.
authors: Cecile
authors: C
authors: Debitus
authors: Department of Chemistry of Natural Compounds, University of Naples, "Federico II", via D. Montesano 49, 80131 Napoli, Italy.
authors: Angela
authors: A
authors: Zampella
mesh_terms: D000818:Animals; D003603:Cytotoxins / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins / Q000494:pharmacology; D047232:Theonella / Q000737:chemistry*
chemical_list: D003603:Cytotoxins; D018942:Macrolides; D008387:Marine Toxins; C086235:swinholide A