title: Imaging of the interaction of cancer cells and the lymphatic system.
abstract: A thorough understanding of the lymphatic system and its interaction with cancer cells is crucial to our ability to fight cancer metastasis. Efforts to study the lymphatic system had previously been limited by the inability to visualize the lymphatic system in vivo in real time. Fluorescence imaging can address these limitations and allow for visualization of lymphatic delivery and trafficking of cancer cells and potentially therapeutic agents as well. Here, we review recent articles in which antibody-fluorophore conjugates are used to label the lymphatic network and fluorescent proteins to label cancer cells in the evaluation of lymphatic delivery and imaging.
authors: Department of Surgery, University of California, San Diego, CA, USA.
authors: Hop S
authors: HS
authors: Tran Cao
authors: Michele
authors: M
authors: McElroy
authors: Sharmeela
authors: S
authors: Kaushal
authors: Robert M
authors: RM
authors: Hoffman
authors: Michael
authors: M
authors: Bouvet
mesh_terms: D000818:Animals; D000906:Antibodies; D003952:Diagnostic Imaging / Q000379:methods*; D005455:Fluorescent Antibody Technique / Q000379:methods; D006801:Humans; D008207:Lymphatic Metastasis; D008208:Lymphatic System / Q000378:metabolism*; D009369:Neoplasms / Q000473:pathology*
chemical_list: D000906:Antibodies