title: Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease.
abstract: In neurons, mitochondria serve a wide variety of processes that are integral to their function and survival. It is, therefore, not surprising that evidence of mitochondrial dysfunction is observed across numerous neurodegenerative diseases. Alzheimer's disease and Parkinson's disease are two such diseases in which aberrant mitochondrial activity is proposed to contribute to pathogenesis. Current therapies for each disease target various mechanisms, but few, if any, directly target improved mitochondrial function. Recent discoveries pertaining to mitochondrial dynamics reveal that regulation of mitochondrial fission and fusion may play a key role in the pathogenesis of these diseases and consequently could be novel future therapeutic targets.
authors: Department of Pathology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA. tmontine@uw.edu.
authors: Jake G
authors: JG
authors: Hoekstra
authors: Kathleen S
authors: KS
authors: Montine
authors: Jing
authors: J
authors: Zhang
authors: Thomas J
authors: TJ
authors: Montine