title: Comparative efficacy of ivermectin and levamisole for reduction of migrating and encapsulated larvae of Baylisascaris transfuga in mice.
abstract: The comparative efficacy of 2 anthelmintics (ivermectin and levamisole) against Baylisascaris transfuga migrating and encapsulated larvae was studied in mice. A total of 60 BALB/c mice inoculated each with about 1,000 embryonated B. transfuga eggs were equally divided into 6 groups (A-F) randomly. Mice of groups A and B were treated with ivermectin and levamisole, respectively, on day 3 post-infection (PI). Mice of groups A-C were killed on day 13 PI. Similarly, groups D and E were treated with ivermectin and levamisole, respectively, on day 14 PI, and all mice of groups D-F were treated on day 24 PI. The groups C and F were controls. Microexamination was conducted to count the larvae recovering from each mouse. The percentages of reduction in the number of migrating larvae recovered from group A (ivermectin) and B (levamisole) were 88.3% and 81.1%, respectively. In addition, the reduction in encapsulated larvae counts achieved by ivermectin (group D) and levamisole (group E) was 75.0% and 49.2%, respectively. The results suggested that, to a certain extent, both anthelmintics appeared to be more effective against migrating larvae than encapsulated larvae. However, in the incipient stage of infection, ivermectin may be more competent than levamisole as a larvicidal drug for B. transfuga.
authors: Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
authors: Yan
authors: Y
authors: Fu
authors: Hua-Ming
authors: HM
authors: Nie
authors: Li-Li
authors: LL
authors: Niu
authors: Yue
authors: Y
authors: Xie
authors: Jia-Bo
authors: JB
authors: Deng
authors: Qiang
authors: Q
authors: Wang
authors: Guang-You
authors: GY
authors: Yang
authors: Xiao-Bin
authors: XB
authors: Gu
authors: Shu-Xian
authors: SX
authors: Wang
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage*; D017191:Ascaridida Infections / Q000188:drug therapy* / Q000469:parasitology; D001199:Ascaridoidea / Q000187:drug effects*; D004195:Disease Models, Animal; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage*; D007814:Larva / Q000187:drug effects; D007978:Levamisole / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012376:Rodent Diseases / Q000188:drug therapy / Q000469:parasitology; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D007978:Levamisole; D007559:Ivermectin