title: Asymmetric palladium-catalyzed hydroarylation of styrenes and dienes.
abstract: Alkenes are desirable and highly versatile starting materials for organic transformations, and well-known substrates for palladium catalysis. Typically, these reactions result in the formation of a new alkene product via β-hydride elimination. In contrast to this scenario, our laboratory has been involved in the development of alkene hydro- and difunctionalization reactions, where β-hydride elimination can be controlled. We report herein the development of an asymmetric palladium-catalyzed hydroarylation, which yields diarylmethine products in up to 75% ee. Interestingly, a linear free energy relationship is observed between the steric bulk of the ligand within a certain range and the enantiomeric excess of the reaction.
authors: Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States.
authors: Susanne M
authors: SM
authors: Podhajsky
authors: Yasumasa
authors: Y
authors: Iwai
authors: Amanda
authors: A
authors: Cook-Sneathen
authors: Matthew S
authors: MS
authors: Sigman