title: Gastric linitis plastica: which role for surgical resection?
abstract: BACKGROUND
  The role of surgery for gastric linitis plastica (GLP) is questioned. This study aimed to analyze our experience in the surgical treatment of GLP with specific reference to the resectability rate, prognosis, and mode of recurrence.
  
  
  METHODS
  Results of surgery were analyzed in 102 patients with GLP.
  
  
  RESULTS
  Of the 102 patients, 92 underwent surgical exploration, with resection performed in 60 cases. R2 resection was carried out in 20 patients and R1 in 12 patients, while the resection was considered potentially curative (R0) in 28 (27.5%). Overall, the median (95% confidence interval [CI]) survival time was 5.7 (3.7-7.5) months, with none of the patients alive at the end date of the study. For R0 patients the median (95% CI) survival time was 15.8 (11-20.7) months. The great majority of recurrences were intra-abdominal (peritoneal and/or locoregional), with a systemic component of the relapse that was rarely observed (5 cases).
  
  
  CONCLUSIONS
  After primary surgery, GLP showed a poor prognosis without regard to the extent or type of resection. The failure of surgical treatment related mainly to the peritoneal spread of the disease. Specifically designed multimodality treatment protocols should be tested in this setting.
authors: Unit of Surgical Oncology, Department of Human Pathology and Oncology, Istituto Toscano Tumouri, University of Siena and ITT, Siena, Italy. pedrazzani@unisi.it
authors: Corrado
authors: C
authors: Pedrazzani
authors: Daniele
authors: D
authors: Marrelli
authors: Fabio
authors: F
authors: Pacelli
authors: Maria
authors: M
authors: Di Cosmo
authors: Gianni
authors: G
authors: Mura
authors: Francesca
authors: F
authors: Bettarini
authors: Fausto
authors: F
authors: Rosa
authors: Giovanni
authors: G
authors: de Manzoni
authors: Franco
authors: F
authors: Roviello
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008039:Linitis Plastica / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome