title: Influence of five neutralizing products on intra-oral pH after rinsing with simulated gastric acid.
abstract: The aetiology of dental erosion may be of both extrinsic and intrinsic origin. The aim of the present study was to test the ability of various neutralizing products to raise the low intra-oral pH after an erosive exposure, in this case to gastric acid, which was simulated using hydrochloric acid (HCl). Eleven adults participated. They rinsed with 10 ml of 10 mM HCl (pH 2) or 10 ml of 100 mM HCl (pH 1) for 1 min, after which the pH was measured intra-orally for up to 30 min at four sites (two approximal, one buccal, and the dorsum of the tongue). After rinsing with the two acid solutions (pH 1 and pH 2), the following products were used: (i) antacid tablet; (ii) gum arabic lozenge; (iii) mineral water; (iv) milk; and (v) tap water (positive control). The negative control was no product use. The five test products were used for 2 min after the erosive challenge. All the products produced an initially higher pH compared with the negative control. The antacid tablet resulted in the greatest and most rapid increase in pH, followed by the lozenge. In dental practice, the use of any of the neutralizing products tested, especially the antacid tablet, could be recommended in order to increase the intra-oral pH after an erosive challenge.
authors: Department of Cariology, Institute of Odontology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. birgitta.lindquist@odontologi.gu.se
authors: Birgitta
authors: B
authors: Lindquist
authors: Peter
authors: P
authors: Lingström
authors: Lars
authors: L
authors: Fändriks
authors: Dowen
authors: D
authors: Birkhed
mesh_terms: D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology; D000818:Animals; D000863:Antacids / Q000494:pharmacology*; D019540:Area Under Curve; D002021:Buffers; D002327:Cariostatic Agents / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000502:physiology*; D006170:Gum Arabic / Q000494:pharmacology; D006801:Humans; D006851:Hydrochloric Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008297:Male; D008892:Milk; D008900:Mineral Waters; D009055:Mouth / Q000187:drug effects / Q000502:physiology*; D009067:Mouthwashes / Q000494:pharmacology; D012463:Saliva / Q000378:metabolism / Q000502:physiology; D012969:Sodium Fluoride / Q000494:pharmacology; D013997:Time Factors; D014077:Tooth Erosion / Q000139:chemically induced; D014867:Water
chemical_list: D000863:Antacids; D002021:Buffers; D002327:Cariostatic Agents; D008900:Mineral Waters; D009067:Mouthwashes; D014867:Water; D000536:Aluminum Hydroxide; D012969:Sodium Fluoride; D006170:Gum Arabic; D006851:Hydrochloric Acid