title: Feasibility of non-coplanar tomotherapy for lung cancer stereotactic body radiation therapy.
abstract: To quantify the dosimetric gains from non-coplanar helical tomotherapy (HT) arcs for stereotactic body radiation therapy (SBRT) of lung cancer, we created oblique helical arcs by rotating patient's CT images. Ten, 20 and 30 degrees of yaws were introduced in the treatment planning for a patient with a hypothetical lung tumor at the upper, middle and lower portion of the right lung, and the upper and middle left lung. The planning target volume (PTV) was 43 cm(3). 60 Gy was prescribed to the PTV. Dose to organs at risk (OARs), which included the lungs, heart, spinal cord and chest wall, was optimized using a 2.5 cm jaw, 0.287 pitch and modulation factor of 2.5. Composite plans were generated by dose summation of the resultant plans. These plans were evaluated for its conformity index (R(x)) and percentile volume of lung receiving radiation dose of x Gy (V(x)). Conformity index was defined by the ratio of x percent isodose volume and PTV. The results show that combination of non-coplanar arcs reduced R(50) by 4.5%, R(20) by 26% and R(10) by 30% on average. Non-coplanar arcs did not affect V(20) but reduced V(10) and V(5) by 10% and 24% respectively. Composite of the non-coplanar arcs also reduced maximum dose to the spinal cord by 20-39%. Volume of chest wall receiving higher than 30 Gy was reduced by 48% on average. Heart dose reduction was dependent on the location of the PTV and the choice of non-coplanar orientations. Therefore we conclude that non-coplanar HT arcs significantly improve critical organ sparing in lung SBRT without changing the PTV dose coverage.
authors: Department of Radiation Oncology University of Virginia 1335 Lee Street, Box 800383 Charlottesville, VA 22908, USA. wensha.yang@cshs.org
authors: Wensha
authors: W
authors: Yang
authors: Ryan
authors: R
authors: Jones
authors: Weiguo
authors: W
authors: Lu
authors: Constance
authors: C
authors: Geesey
authors: Stanley
authors: S
authors: Benedict
authors: Paul
authors: P
authors: Read
authors: James
authors: J
authors: Larner
authors: Ke
authors: K
authors: Sheng
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy*; D000077192:Adenocarcinoma of Lung; D054893:Cone-Beam Computed Tomography / Q000379:methods; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D011857:Radiographic Image Interpretation, Computer-Assisted; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods