title: Study on the expression and clinical significances of lewis y antigen and integrin αv, β3 in epithelial ovarian tumors.
abstract: OBJECTIVE
  To detect the expression and clinical significances of Lewis y antigen and integrin αv, β3 in epithelial ovarian tumors, and to explore the expression correlation between Lewis y antigen and integrin αv, β3.
  
  
  METHODS
  Immunohistochemical staining was performed in 95 cases of epithelial ovarian cancer, 37 cases of borderline tumors, 20 cases of benign tumors, and 20 cases of normal ovarian tissue, for the detection of Lewis y antigen and integrin αv, β3 expressions, and to analyze the relationship between Lewis y antigen and integrin, and the relationship between clinical and pathological parameters of ovarian cancer. In addition, immunofluorescence double labeling was utilized to detect the expression correlation between Lewis y antigen and integrin αv, β3 in ovarian cancer.
  
  
  RESULTS
  In epithelial ovarian tumors, the expression rate of Lewis y antigen was 81.05%, significantly higher than that of borderline (51.53%) (P < 0.05) and benign (25%) (P < 0.01) tumors, and normal ovarian tissues (0) (P < 0.01). The expression rate of integrin αv, β3 in malignant epithelial ovarian tumors was 78.95% and 82.11%, respectively, significantly higher than that of the borderline (45.94%, 40.54%) (both P < 0.05), benign group (10.00%, 15.00%) (both P < 0.01) and normal ovary group (5%, 15%) (both P < 0.01).
  
  
  CONCLUSIONS
  Lewis y and integrins αv, β3 are relevant to pelvic and abdominal diffusion and metastasis of ovarian cancer cells, suggesting that these two molecules mediate a boosting function for tumor metastasis.
authors: Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China; E-Mails: converting@163.com (Y.W.); juanjuanliu_lg@yahoo.com.cn (J.L.); dwli_ll@163.com (Q.L.); liushuicc@sina.com (S.L.); limeimei@126.com (L.Y.); zhangshl99@126.com (S.Z.).
authors: Yifei
authors: Y
authors: Wang
authors: Juanjuan
authors: J
authors: Liu
authors: Bei
authors: B
authors: Lin
authors: Changzhi
authors: C
authors: Wang
authors: Quanrong
authors: Q
authors: Li
authors: Shuice
authors: S
authors: Liu
authors: Limei
authors: L
authors: Yan
authors: Shulan
authors: S
authors: Zhang
authors: Masao
authors: M
authors: Iwamori
mesh_terms: D000008:Abdominal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D000328:Adult; D000368:Aged; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D007983:Lewis Blood Group Antigens / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D005456:Fluorescent Dyes; D039302:Integrin alphaVbeta3; D007983:Lewis Blood Group Antigens; C094162:Lewis Y antigen