title: Highly enantioslective synthesis of multisubstituted polyfunctional dihydropyrrole via an organocatalytic tandem Michael/cyclization sequence.
abstract: A unique approach to asymmetric synthesis of various optically pure multisubstituted 2,3-dihydropyrroles catalyzed by a novel rosin-derived tertiary amine-thiourea via a tandem Michael/cyclization sequence with high yield (up to 97%) and good to excellent enantioselectivities (up to 97% ee) is present. This strategy provides an efficient and convenient method to access enantioenrich nitrogen heterocycles.
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, China.
authors: Gen
authors: G
authors: Zhang
authors: Yaohu
authors: Y
authors: Zhang
authors: Xianxing
authors: X
authors: Jiang
authors: Wenjin
authors: W
authors: Yan
authors: Rui
authors: R
authors: Wang
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D006865:Hydrogenation; D008958:Models, Molecular; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D011758:Pyrroles