title: Predictive clinical parameters for the therapeutic efficacy of sitagliptin in korean type 2 diabetes mellitus.
abstract: BACKGROUND
  Sitagliptin is a highly selective dipeptidyl peptide-4 (DPP-4) inhibitor that increases blood levels of active glucagon-like peptide (GLP)-1 and glucose-dependent insulinotrophic polypeptide (GIP), resulting in increased insulin secretion. While studies conducted in other countries have indicated the efficacy and safety of using sitagliptin to treat type 2 diabetes mellitus (T2DM), its predictors of effects to sitagliptin are not well understood. Therefore, we evaluated the predictive clinical parameters for the therapeutic benefits of sitagliptin when added to an ongoing metformin or sulfonylurea therapy in Korean T2DM subjects.
  
  
  METHODS
  We obtained data from 251 Korean T2DM subjects who had recently started taking sitagliptin as add-on therapy. Exclusion criteria included any insulin use. Changes in HbA1c (ΔHbA1c) and fasting plasma glucose (ΔFPG) were assessed by comparing baseline levels prior to sitagliptin administration to levels 12 and 24 weeks after treatment. Responders were defined as subjects who experienced decrease from baseline of >10% in ΔHbA1c or >20% in ΔFPG levels at 24 weeks.
  
  
  RESULTS
  We classified 81% of the subjects (204 out of 251) as responders. The responder group had a lower mean body mass index (23.70±2.40 vs. 26.00±2.26, P≤0.01) and were younger (58.83±11.57 years vs. 62.87±12.09 years, P=0.03) than the non-responder group.
  
  
  CONCLUSIONS
  In Korean T2DM subjects, sitagliptin responders had lower body mass index and were younger compared to non-responders.
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors: Soon Ae
authors: SA
authors: Kim
authors: Woo Ho
authors: WH
authors: Shim
authors: Eun Hae
authors: EH
authors: Lee
authors: Young Mi
authors: YM
authors: Lee
authors: Sun Hee
authors: SH
authors: Beom
authors: Eun Sook
authors: ES
authors: Kim
authors: Jeong Seon
authors: JS
authors: Yoo
authors: Ji Sun
authors: JS
authors: Nam
authors: Min Ho
authors: MH
authors: Cho
authors: Jong Suk
authors: JS
authors: Park
authors: Chul Woo
authors: CW
authors: Ahn
authors: Kyung Rae
authors: KR
authors: Kim