title: [Isolation and structure of novel peptide inhibitor of HIV-1 integrase from marine polychaetes].
abstract: A homogeneous peptide with m683 Da which inhibits HIV-1 integrase with IC50 3 x 10(-5) M was separated from aqueous extracts of marine worm Eunicidae sp. by multi-stage chromatography purification. The structure Asp-Leu-Hse-His-Ala-G1n was proposed for this peptide according to the amino acid analysis, automated amino acid Edman sequencing, TLC with the witness and homoserine MS/MS fragmentation. The proposed structure is the first example of natural peptide containing amino acid homoserine residue.
authors: L A
authors: LA
authors: Eliakova
authors: B V
authors: BV
authors: Vas'kovskiĭ
authors: N I
authors: NI
authors: Khoroshilova
authors: S I
authors: SI
authors: Vantseva
authors: Iu Iu
authors: IuIu
authors: Agapkina
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002845:Chromatography; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D019427:HIV Integrase / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000032:analysis*; D015497:HIV-1 / Q000502:physiology*; D006714:Homoserine; D006801:Humans; D013058:Mass Spectrometry; D010446:Peptide Fragments / Q000032:analysis*; D011077:Polychaeta / Q000502:physiology
chemical_list: D019428:HIV Integrase Inhibitors; D010446:Peptide Fragments; D006714:Homoserine; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1