title: Serum prolidase activity in patients with pulmonary tuberculosis.
abstract: OBJECTIVE
  To investigate serum prolidase activity (SPA) in patients with pulmonary tuberculosis (PTB).
  
  
  METHODS
  Twenty-nine PTB patients and 32 controls were included in the study. PTB patients (cavitary and non-cavitary) and controls were compared in terms of mean SPA. Correlations were evaluated between SPA and acute phase reactants.
  
  
  RESULTS
  Mean SPA was significantly higher in PTB patients than in the control group. Mean SPA was significantly higher in patients with cavitary TB than non-cavitary TB. Mean SPA in patients with mild PTB was lower than patients with moderate and severe disease. We found significant correlations between SPA and CRP, ESR, albumin, platelet counts, HDL-cholesterol and LDH activity.
  
  
  CONCLUSIONS
  This study has shown that PTB patients have higher SPA than controls. The increase in SPA might be related to tissue destruction, increased immunoglobulin, complement levels and increased fibroblastic activity; all of which are involved in the natural history of PTB.
authors: Department of Pulmonary Medicine, Gulhane Military Medical Academy, Ankara, Turkey. seyfettingumus@gmail.com
authors: Seyfettin
authors: S
authors: Gumus
authors: Halil
authors: H
authors: Yaman
authors: Omer
authors: O
authors: Ozcan
authors: Omer
authors: O
authors: Deniz
authors: Bulent
authors: B
authors: Karaman
authors: Erdinc
authors: E
authors: Cakir
authors: Ergun
authors: E
authors: Tozkoparan
authors: Metin
authors: M
authors: Ozkan
authors: Hayati
authors: H
authors: Bilgic
mesh_terms: D000293:Adolescent; D000328:Adult; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D004150:Dipeptidases / Q000097:blood*; D057075:Enzyme Assays; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009169:Mycobacterium tuberculosis; D010976:Platelet Count; D012372:ROC Curve; D012709:Serum Albumin / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000382:microbiology; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D012709:Serum Albumin; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase; D004150:Dipeptidases; C022449:proline dipeptidase