title: Effect of cholesterol and CYP46 polymorphism on cognitive event-related potentials.
abstract: The integrated effect of the cholesterol and CYP46 genotypes on the risk of cognitive decline needs to be determined. Using the Cognitive Abilities Screening Instrument (CASI), 145 mentally healthy middle-aged and older adults were recruited to investigate the influence of cholesterol and CYP46 genotypes on cognitive event-related potentials (ERPs). The subjects with a high low-density lipoprotein cholesterol (LDL-C) level displayed significantly lower amplitude ERPs, although the CASI scores showed no difference. There was no association between the CYP46 genotypes, CASI scores, cholesterol levels, and measures of ERPs. No interaction between LDL-C level and CYP46 genotypes was noted. The LDL-C level is an independent predictor of low P300 amplitude. Prevention and treatment of high cholesterol may be of potential benefit in reducing cognitive impairment.
authors: Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, TaiwanDepartment of Guidance and Counseling, National Changhua University of Education, Taiwan.
authors: Chiou-Lian
authors: CL
authors: Lai
authors: Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, TaiwanDepartment of Guidance and Counseling, National Changhua University of Education, Taiwan.
authors: Chung-Yao
authors: CY
authors: Hsu
authors: Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, TaiwanDepartment of Guidance and Counseling, National Changhua University of Education, Taiwan.
authors: Li-Min
authors: LM
authors: Liou
authors: Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, TaiwanDepartment of Guidance and Counseling, National Changhua University of Education, Taiwan.
authors: Hsin-Yi
authors: HY
authors: Hsieh
authors: Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, TaiwanDepartment of Guidance and Counseling, National Changhua University of Education, Taiwan.
authors: Yi-Hsing
authors: YH
authors: Hsieh
authors: Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, TaiwanDepartment of Guidance and Counseling, National Changhua University of Education, Taiwan.
authors: Ching-Kuan
authors: CK
authors: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002784:Cholesterol / Q000097:blood*; D000072556:Cholesterol 24-Hydroxylase; D003071:Cognition / Q000502:physiology*; D005071:Evoked Potentials / Q000235:genetics / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013250:Steroid Hydroxylases / Q000235:genetics*
chemical_list: D002784:Cholesterol; D013250:Steroid Hydroxylases; D000072556:Cholesterol 24-Hydroxylase