title: Sertaconazole nitrate shows fungicidal and fungistatic activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, causative agents of tinea pedis.
abstract: The fungistatic and fungicidal activities of sertaconazole against dermatophytes were evaluated by testing 150 clinical isolates of causative agents of tinea pedis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum. The overall geometric means for fungistatic and fungicidal activities of sertaconazole against these isolates were 0.26 and 2.26 μg/ml, respectively, although values were higher for T. mentagrophytes than for the others. This is the first comprehensive demonstration of the fungicidal activity of sertaconazole against dermatophytes.
authors: Department of Microbiology, ACIAM, P.O. Box 10178, E-08080 Barcelona, Spain. acarrillo@aciam.es
authors: Alfonso J
authors: AJ
authors: Carrillo-Muñoz
authors: Cristina
authors: C
authors: Tur-Tur
authors: Delia C
authors: DC
authors: Cárdenes
authors: Dolors
authors: D
authors: Estivill
authors: Gustavo
authors: G
authors: Giusiano
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D004821:Epidermophyton / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013876:Thiophenes / Q000494:pharmacology*; D014008:Tinea Pedis / Q000382:microbiology*; D014249:Trichophyton / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D013876:Thiophenes; C061131:sertaconazole