title: Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease.
abstract: Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.
authors: Department of Basic Nursing, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
authors: Adaliene Versiani Matos
authors: AV
authors: Ferreira
authors: Marcela
authors: M
authors: Segatto
authors: Zélia
authors: Z
authors: Menezes
authors: Andréa Mara
authors: AM
authors: Macedo
authors: Cláudio
authors: C
authors: Gelape
authors: Luciana
authors: L
authors: de Oliveira Andrade
authors: Fnu
authors: F
authors: Nagajyothi
authors: Philipp E
authors: PE
authors: Scherer
authors: Mauro Martins
authors: MM
authors: Teixeira
authors: Herbert B
authors: HB
authors: Tanowitz
mesh_terms: D052438:Adipocytes, White / Q000469:parasitology*; D000273:Adipose Tissue / Q000469:parasitology*; D000368:Aged; D000818:Animals; D016022:Case-Control Studies; D014355:Chagas Disease / Q000469:parasitology*; D002908:Chronic Disease; D018105:DNA, Kinetoplast / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006321:Heart / Q000469:parasitology*; D006327:Heart Block / Q000469:parasitology; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D014349:Trypanosoma cruzi / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D018105:DNA, Kinetoplast