title: Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in.
abstract: The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent effectors.
authors: Department of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
authors: Yme U
authors: YU
authors: van der Velden
authors: Anna-Pavlina G
authors: AP
authors: Haramis
mesh_terms: D000818:Animals; D016764:Cell Polarity; D004734:Energy Metabolism; D006801:Humans; D010580:Peutz-Jeghers Syndrome / Q000473:pathology / Q000503:physiopathology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*; D015027:Zebrafish / Q000502:physiology*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D025521:Tumor Suppressor Proteins; D029961:Zebrafish Proteins; D017346:Protein Serine-Threonine Kinases