title: Are serum markers altered in first trimester screening in poor ovarian reserve patients?
abstract: OBJECTIVE
  To investigate whether serum biochemical markers were altered during first trimester screenings in patients who have diminished ovarian reserve.
  
  
  METHODS
  One hundred and fifty-one women who conceived after intracytoplasmic sperm injection were enrolled during the 11- to 14-week scan between June 2006 and July 2008. The normoresponders (Group 1: 125 patients) had >6 oocytes and the poor responders (Group 2: 26 patients) had ≤6 oocytes in oocyte retrieval. The means of the multiples of the median (MoM) of pregnancy-associated plasma protein A (PAPP-A), free β-human chorionic gonadotropin (β-hCG) and nuchal translucency of the poor responder and normoresponder groups were compared and a potential relationship between serum markers and poor ovarian reserve was investigated. Data were analyzed with the Student's t-test, χ2-test and Mann-Whitney two sample test (unpaired, nonparametric). P < 0.05 was considered significant.
  
  
  RESULTS
  The means of the MoMs of the poor responders and normoresponders were 1.16 ± 0.45 and 1.04 ± 0.32 (P = 0.111) for nuchal translucency, 0.92 ± 0.48 and 0.89 ± 0.61 (P = 0.399) for PAPP-A, and 1.08 ± 0.40 and 1.21 ± 0.95 (P = 0.831) for β-hCG, respectively.
  
  
  CONCLUSIONS
  There was no statistically significant difference between the groups in serum biochemical markers, nuchal translucency means and screen positive rates during the first trimester screening.
authors: Department of Obstetrics and Gynecology, Başkent University School of Medicine, Ankara, Turkey. ayseparlakgumus@yahoo.de
authors: Huriye A
authors: HA
authors: Parlakgumus
authors: Bulent
authors: B
authors: Haydardedeoglu
authors: Erhan
authors: E
authors: Simsek
authors: Esra
authors: E
authors: Bulgan Kilicdag
authors: Tayfun
authors: T
authors: Bagis
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005260:Female; D006801:Humans; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A