title: The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis.
abstract: Local estrogen metabolism and its sensitivities in the skin have been also suggested to contribute to skin homeostasis in addition to age- and/or gender-dependent circulating estrogen, even though their local mechanisms have been largely unknown. To characterize their potential correlations, age- and gender-dependencies were evaluated focusing on 5 pivotal estrogen-metabolizing enzymes including aromatase, estrogen sulfotransferase, steroid sulfatase, and 17β-hydroxysteroid dehydrogenases and estrogen receptors (ERα and ERβ) using immunohistochemistry of 100 human skin specimens. When their epidermal expression levels were compared among 7 age groups, ranging from the teens to the seventies, the highest expression in the teens group and the lowest expression in the seventies group were found in the expression of aromatase and ERβ, respectively, while no significant differences between the male and the female groups were found in the immunoreactivities of our interested proteins. Our results suggest that age-related differences in aromatase and ERβ expressions impact epidermal homeostasis.
authors: Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
authors: Takayoshi
authors: T
authors: Inoue
authors: Yasuhiro
authors: Y
authors: Miki
authors: Keiko
authors: K
authors: Abe
authors: Masahito
authors: M
authors: Hatori
authors: Masami
authors: M
authors: Hosaka
authors: Yoshiyuki
authors: Y
authors: Kariya
authors: Shingo
authors: S
authors: Kakuo
authors: Tsutomu
authors: T
authors: Fujimura
authors: Akira
authors: A
authors: Hachiya
authors: Setsuya
authors: S
authors: Aiba
authors: Hironobu
authors: H
authors: Sasano
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001141:Aromatase / Q000378:metabolism; D002648:Child; D004817:Epidermis / Q000201:enzymology* / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D043266:Steryl-Sulfatase / Q000378:metabolism; D015238:Sulfotransferases / Q000378:metabolism; D055815:Young Adult
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D015067:17-Hydroxysteroid Dehydrogenases; D001141:Aromatase; D015238:Sulfotransferases; C020122:estrone sulfotransferase; D043266:Steryl-Sulfatase