title: Anti-visceral obesity and antioxidant effects of powdered sea buckthorn (Hippophae rhamnoides L.) leaf tea in diet-induced obese mice.
abstract: The potential health benefits of tea have long been studied. This study examined the role of powdered sea buckthorn leaf tea (SLT) in high-fat diet-induced obese mice. The mice were fed two different doses of SLT (1% and 5%, wt/wt) for six weeks. SLT suppressed body weight gain in a dose-dependent manner and significantly reduced visceral fat, plasma levels of leptin, triglyceride and total cholesterol and ALT activity compared with the high-fat-fed control mice. SLT also decreased hepatic triglyceride and cholesterol concentrations and lipid accumulation, whereas elevated fecal lipid excretion. High-fat feeding resulted in simultaneously decreasing hepatic FAS and G6PD activities and increasing PAP, β-oxidation and CPT activities. However, SLT supplementation during high-fat feeding led to a significant decrease in PAP, β-oxidation and CPT activities with a simultaneous increase in G6PD activity. The hepatic CYP2E1 activity and hepatic and erythrocyte lipid peroxides were significantly lowered with SLT supplements. Hepatic and erythrocyte SOD and CAT activities were also increased with SLT supplements in a dose-dependent manner, whereas GSH-Px activity was increased in erythrocytes only. These results indicate that SLT has potential anti-visceral obesity and antioxidant effects mediated by the regulation of lipid and antioxidant metabolism in high-fat diet-induced obese mice.
authors: Department of Food and Nutrition, Sunchon National University, Suncheon 540-742, Republic of Korea.
authors: Hae-In
authors: HI
authors: Lee
authors: Mi-Su
authors: MS
authors: Kim
authors: Kyung-Mi
authors: KM
authors: Lee
authors: Seok-Kyu
authors: SK
authors: Park
authors: Kwon-Il
authors: KI
authors: Seo
authors: Hye-Jin
authors: HJ
authors: Kim
authors: Myung-Joo
authors: MJ
authors: Kim
authors: Myung-Sook
authors: MS
authors: Choi
authors: Mi-Kyung
authors: MK
authors: Lee
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage*; D031281:Hippophae / Q000737:chemistry*; D020738:Leptin / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D056128:Obesity, Abdominal / Q000188:drug therapy*; D011208:Powders; D013662:Tea; D015430:Weight Gain
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D020738:Leptin; D011208:Powders; D013662:Tea