title: Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer.
abstract: Matrix metalloproteinases (MMPs) are implicated in cancer development and progression and are associated with prognosis. Single-nucleotide polymorphisms (SNPs) of MMPs, most frequently located in the promoter region of the genes, have been shown to influence cancer susceptibility and/or progression. SNPs of MMP-1, -2, -3, -7, -8, -9, -12, -13 and -21 and of the tissue inhibitor of metalloproteinases (TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors. The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper.
authors: Alexandra MJ Langers, Hein W Verspaget, Daniel W Hommes, Cornelis FM Sier, Department of Gastroenterology and Hepatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors: Alexandra Mj
authors: AM
authors: Langers
authors: Hein W
authors: HW
authors: Verspaget
authors: Daniel W
authors: DW
authors: Hommes
authors: Cornelis Fm
authors: CF
authors: Sier