title: Effect of the use of carprofen in dogs undergoing intense rehabilitation after lateral fabellar suture stabilization.
abstract: OBJECTIVE
  To determine whether carprofen, a commercially available NSAID, would decrease perceived exertion and signs of pain in dogs and therefore increase muscle mass and hind limb function without decreasing range of motion after lateral fabellar suture stabilization.
  
  
  METHODS
  Randomized, blinded, controlled clinical trial.
  
  
  METHODS
  35 dogs with cranial cruciate ligament rupture and lateral fabellar suture stabilization followed by rehabilitation.
  
  
  METHODS
  All dogs underwent surgical stabilization of cranial cruciate ligament rupture by placement of a lateral fabellar suture. Dogs received carprofen (2.2 mg/kg [1 mg/lb], PO, q 12 h) for the first 7 days after surgery and underwent concentrated rehabilitation exercises during weeks 3, 5, and 7 after surgery. Eighteen dogs also received carprofen (2.2 mg/kg, PO, q 12 h) during the weeks of concentrated rehabilitation. Outcomes were measured by a single investigator, who was blinded to group assignments, using pressure platform gait analysis, goniometry, thigh circumference, and mean workout speed at a consistent level of exertion.
  
  
  RESULTS
  There were no differences between the 2 groups in ground reaction forces, thigh circumference, or exertion (mean workout speed) over time or at any individual time point. However, both groups improved significantly over time for all outcome measures.
  
  
  CONCLUSIONS
  Providing carprofen to dogs during concentrated rehabilitation after lateral fabellar suture stabilization did not improve hind limb function, range of motion, or thigh circumference, nor did it decrease perceived exertion, compared with control dogs. Carprofen was not a compulsory component of a physical therapy regimen after lateral fabellar suture stabilization.
authors: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA. wgordonevans@gmail.com
authors: Wanda J
authors: WJ
authors: Gordon-Evans
authors: Diane
authors: D
authors: Dunning
authors: Ann L
authors: AL
authors: Johnson
authors: Kim E
authors: KE
authors: Knap
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001696:Biomechanical Phenomena; D002227:Carbazoles / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D007794:Lameness, Animal / Q000601:surgery; D010146:Pain / Q000188:drug therapy / Q000662:veterinary*; D010805:Physical Conditioning, Animal; D011183:Postoperative Complications / Q000534:rehabilitation / Q000662:veterinary; D012046:Rehabilitation / Q000379:methods*; D012421:Rupture / Q000601:surgery / Q000662:veterinary*; D013264:Stifle / Q000601:surgery
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; C007005:carprofen