title: A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer.
abstract: Lung cancer is the first cause of cancer mortality worldwide, and its early detection is currently the main available strategy to improve disease prognosis. While early diagnosis can be successfully achieved through tomography-based population screenings in high-risk individuals, simple methodologies are needed for effective cancer prevention programs. We developed a test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of asymptomatic high-risk individuals with 80% accuracy. The signature could assign disease probability accurately either in asymptomatic or symptomatic patients, is able to distinguish between benign and malignant lesions, and to capture the onset of the malignant disease in individual patients over time. Thus, our test displays a number of features of clinical relevance that project its utility in programs for the early detection of NSCLC.
authors: IFOM, The FIRC Institute for Molecular Oncology Foundation, At the IFOM-IEO Campus, Milan, Italy.
authors: Fabrizio
authors: F
authors: Bianchi
authors: Francesco
authors: F
authors: Nicassio
authors: Matteo
authors: M
authors: Marzi
authors: Elena
authors: E
authors: Belloni
authors: Valentina
authors: V
authors: Dall'olio
authors: Loris
authors: L
authors: Bernard
authors: Giuseppe
authors: G
authors: Pelosi
authors: Patrick
authors: P
authors: Maisonneuve
authors: Giulia
authors: G
authors: Veronesi
authors: Pier Paolo
authors: PP
authors: Di Fiore
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D044967:Serum / Q000737:chemistry
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs