title: Comparative analysis of tumour angiogenesis in solid multicystic and unicystic ameloblastoma by using CD 105 (endoglin).
abstract: OBJECTIVE
  The aim of the present study was to evaluate and compare the expression of CD105 (endoglin) in solid multicystic ameloblastoma (SMA) and unicystic ameloblastoma (UA).
  
  
  METHODS
  Angiogenesis was assessed in 20 SMA, 15 UA and 10 normal oral mucosa samples by measuring the mean vascular density (MVD), total vascular area (TVA) and mean vascular area (MVA). The immunohistochemistry was carried out by using monoclonal mouse anti-human antibody against CD105.
  
  
  RESULTS
  The Kruskal-Wallis test showed significant difference in mean MVD, TVA, and MVA between SMA, UA, and control group (p<0.001). Using the Mann-Whitney test, the mean MVD, TVA and MVA, was statistically significant between SMA and control group (p<0.001) as well as between UA and control group (p<0.001). No significant difference of mean MVD, TVA, and MVA, was observed between SMA and UA (p>0.05).
  
  
  CONCLUSIONS
  Our study results show no significant difference in MVD, TVA and MVA between SMA and UA. This may reflect the fact that though clinical behaviour, histopathological presentation and prognosis of SMA and UA differ, the process of angiogenesis is not different. This suggests that the angiogenesis has an important role in tumour progression and invasiveness of ameloblastoma. Measurement and assessment of tumour angiogenesis may prove very valuable in predicting response to antiangiogenic therapeutic strategies and also provide objective assessment of post therapeutic response particularly in recurrent cases of SMA and UA.
authors: Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, Maharashtra, Postal code: 442001, India. alkahandel@yahoo.com
authors: Alka H
authors: AH
authors: Hande
authors: Amol R
authors: AR
authors: Gadbail
authors: Archana M
authors: AM
authors: Sonone
authors: Minal S
authors: MS
authors: Chaudhary
authors: Vijay
authors: V
authors: Wadhwan
authors: Atul
authors: A
authors: Nikam
mesh_terms: D000564:Ameloblastoma / Q000378:metabolism* / Q000473:pathology; D015703:Antigens, CD / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D018450:Disease Progression; D000071063:Endoglin; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D007573:Jaw Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface