title: [No complaints, but constantly elevated cholestatic serum liver tests].
abstract: A 75 year old woman presented with long-lasting pruritus and elevation of serum levels of alkaline phosphatase and gamma-glutamyl transpeptidase (GGT). Potentially hepatotoxic drugs were stopped; an abdominal ultra-sonography was normal. Antimitochondrial antibodies were elevated and are the serologic hallmark of primary biliary cirrhosis. The disease can progress from an asymptomatic inflammation to a cirrhosis. The disease-modifying treatment consists in ursodeoxycholic acid 13-15 mg/kg per day. Concomitant to the primary biliary cirrhosis hypothyroidism, osteoporosis, malabsorption and dyslipidemia can occur.
authors: Praxisassistenzarzt in allgemeinmedizinischer Hausarztpraxis, Thal. habib.kherbeche@kssg.ch
authors: H
authors: H
authors: Kherbèche
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D001323:Autoantibodies / Q000097:blood; D015209:Cholangitis, Sclerosing / Q000175:diagnosis* / Q000188:drug therapy / Q000201:enzymology; D002779:Cholestasis / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis* / Q000188:drug therapy / Q000201:enzymology; D008111:Liver Function Tests; D008930:Mitochondria, Liver / Q000276:immunology; D014463:Ultrasonography; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D001323:Autoantibodies; D014580:Ursodeoxycholic Acid; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase