title: [N-6 fatty acids and cardiovascular health: dietary intake recommendations].
abstract: Omega-6 polyunsaturated fatty acids (n-6 PUFA) are well known for their critical role in many physiological functions and reduce risks of cardiovascular disease (CVD). However, some argue that excessive consumption of n-6 PUFA may lead to adverse effects on health and therefore recommend reducing dietary n-6 PUFA intake or fixing an upper limit. Epidemiological studies show that n-6 PUFA dietary intake significantly lowers blood LDL-cholesterol levels. In addition, n-6 PUFA intake lower several cardiovascular risk factors such as blood pressure, inflammatory markers, haemostatic parameters and obesity. Data from prospective cohort and interventional studies converge towards a specific protective role of dietary n-6 PUFA intake, in particular linoleic acid, against CVD. In regards to studies examined in this narrative review, recommendation for n-6 PUFA intake above 5%, and ideally about 10% of total energy appears justified for the prevention of ischemic heart disease.
authors: Unité de recherche d'épidémiologie nutritionnelle, UMR Inserm U557, INRA, CNAM, UP13, CRNH-Idf, Faculté SMBH, 74, rue Marcel Cachin, 93017 Bobigny, France. czernichow@uren.smbh.univ-paris13.fr
authors: Sébastien
authors: S
authors: Czernichow
authors: Daniel
authors: D
authors: Thomas
authors: Eric
authors: E
authors: Bruckert
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D032921:Consensus; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage / Q000502:physiology* / Q000633:toxicity; D014943:Global Health; D006801:Humans; D006949:Hyperlipidemias / Q000517:prevention & control; D007249:Inflammation / Q000139:chemically induced; D015227:Lipid Peroxidation; D051379:Mice; D018673:Nutrition Policy; D009751:Nutritional Requirements; D009765:Obesity / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D018384:Oxidative Stress; D016032:Randomized Controlled Trials as Topic; D013045:Species Specificity
chemical_list: D043371:Fatty Acids, Omega-6