title: Synthesis of 5-iodo-1,2,3-triazole-containing macrocycles using copper flow reactor technology.
abstract: A new macrocyclization strategy to synthesize 12- to 31-membered 5-iodo-1,2,3-triazole-containing macrocycles is described. The macrocycles have been generated using a simple and efficient copper-catalyzed cycloaddition in flow under environmentally friendly conditions. This methodology also permits the facile, regioselective synthesis of 1,4,5-trisubstituted-1,2,3-triazole-containing macrocyles using palladium-catalyzed cross-coupling reactions.
authors: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors: Andrew R
authors: AR
authors: Bogdan
authors: Keith
authors: K
authors: James
mesh_terms: D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D047028:Macrocyclic Compounds / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D014230:Triazoles / Q000737:chemistry*
chemical_list: C568583:5-iodo-1,2,3-triazole; D047028:Macrocyclic Compounds; D014230:Triazoles; D003300:Copper