title: Synthesis and catalytic properties of 4-aryl-2,3-dihydro-4H-pyrimido[2,3-b]benzothiazoles for asymmetric acyl or carboxyl group transfer reactions.
abstract: 4-Aryl-2,3-dihydro-4H-pyrimido[2,3-b]benzothiazoles (4-Ar-DHPBs) were synthesized and their catalytic activity and selectivity in kinetic resolution of a secondary alcohol as well as in the Steglich rearrangement and related reactions were evaluated. 4-Aryl-DHPBs showed low enantioselectivity in the acylative kinetic resolution of 1-phenylethanol. Conversely, they catalyzed the Steglich rearrangement with moderate to excellent enantioselectivity, demonstrating the possibility for remote stereocontrol by introduction of a substituent at the 4-position of DHPB.
authors: Department of Material & Life Chemistry, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
authors: Baby
authors: B
authors: Viswambharan
authors: Tatsuya
authors: T
authors: Okimura
authors: Satoko
authors: S
authors: Suzuki
authors: Sentaro
authors: S
authors: Okamoto