title: No gender differences in prognosis and preventive treatment in patients with AMI without significant stenoses.
abstract: OBJECTIVE
  To investigate possible gender differences in patients with acute myocardial infarction (AMI) and without significant stenoses on coronary angiography (CAG) regarding prognosis and use of secondary preventive medication.
  
  
  METHODS
  Nationwide register-based cohort study.
  
  
  METHODS
  By compiling data from Danish registries, we identified 20,800 patients hospitalized with AMI during 2005-2007. We included the 834 women and 761 men without significant stenoses on CAG who were discharged and alive after 60 days.
  
  
  METHODS
  All-cause mortality, recurrent AMI, and redeeming a prescription for a lipid-lowering drug, beta-blocker, clopidogrel, or aspirin within 60 days of discharge.
  
  
  RESULTS
  During follow-up, 97 women and 60 men died, resulting in a crude female/male hazard ratio (HR) of 1.51 (95% CI 1.09-2.08). After adjustment for age, time-period, and comorbidity, the gender difference was attenuated (HR 1.22, 95% CI 0.86-1.72). AMI recurrence was experienced by 28 women and 29 men with a female/male HR 0.88 (95% CI 0.52-1.48). After multivariable adjustment results were similar (HR 0.84, 95% CI 0.50-1.43). More women than men redeemed a prescription for lipid-lowering drugs with no differences in other medication. In the adjusted models lipid-lowering drugs, beta-blockers, clopidogrel, and aspirin were all redeemed equally with odds ratio (OR) 1.25 (95% CI 0.99-1.59), OR 1.10 (95% CI 0.88-1.37), OR 1.09 (95% CI 0.88-1.34), and OR 1.13 (95% CI 0.90-1.42), respectively.
  
  
  CONCLUSIONS
  Our study shows that in a population of patients with a first admission for AMI and no significant stenoses on CAG, women share the same prospects as men regarding long-term prognosis and the extent of secondary preventive medical treatment.
authors: Copenhagen University Hospital Gentofte, Hellerup, Denmark. khan0171@geh.regionh.dk
authors: Kim Wadt
authors: KW
authors: Hansen
authors: Anders
authors: A
authors: Hvelplund
authors: Steen Zabell
authors: SZ
authors: Abildstrøm
authors: Eva
authors: E
authors: Prescott
authors: Mette
authors: M
authors: Madsen
authors: Jan Kyst
authors: JK
authors: Madsen
authors: Jan Skov
authors: JS
authors: Jensen
authors: Leif
authors: L
authors: Thuesen
authors: Per
authors: P
authors: Thayssen
authors: Hans Henrik
authors: HH
authors: Tilsted
authors: Erik
authors: E
authors: Jørgensen
authors: Søren
authors: S
authors: Galatius
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D015897:Comorbidity; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000453:epidemiology; D003718:Denmark / Q000453:epidemiology; D005260:Female; D054624:Health Status Disparities; D054625:Healthcare Disparities; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012008:Recurrence; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D055502:Secondary Prevention; D012737:Sex Factors; D013997:Time Factors
chemical_list: D002317:Cardiovascular Agents