title: Field evaluations of the efficacy and safety of Emodepside plus toltrazuril (Procox® oral suspension for dogs) against naturally acquired nematode and Isospora spp. infections in dogs.
abstract: Three controlled, blinded and randomised multicentre field studies evaluated the efficacy and safety of a new formulation containing emodepside plus toltrazuril (Procox® suspension for dogs) against naturally acquired parasite infections in dogs. In two studies dogs positive for gastrointestinal nematodes and/or Isospora spp. were treated with emodepside/toltrazuril suspension (at least 0.45 mg emodepside plus 9 mg toltrazuril per kg body weight) or a reference product containing either milbemycin oxime plus praziquantel (Milbemax®) or sulfadimethoxine (Kokzidiol SD®) at recommended dose rates. The third study investigated efficacy against prepatent natural Isospora spp. infections in comparison to an untreated control group by enrolling Isospora- negative dogs that were at risk to develop a patent infection during the study.No suspected adverse drug reactions were observed in any of the 403 dogs enrolled in the three studies including 234 dogs treated with emodepside/toltrazuril suspension. In dogs treated with emodepside/toltrazuril suspension against nematode infection faecal egg counts were reduced by 100 % (reference product: 99.7 %). Similarly, in the dogs that had been treated against patent Isospora spp. infection, faecal oocyst counts were reduced by 100 % (reference product: 99.0 %). In both studies, statistical analysis demonstrated non-inferiority and even superiority to the reference products (p ≤ 0.009). Dogs treated with emodepside/toltrazuril suspension during suspected prepatent Isospora spp. infection had 98.7 % lower faecal oocyst counts after treatment compared to untreated dogs (p < 0.0001).The studies demonstrated that emodepside/toltrazuril suspension is safe and highly efficacious against nematodes and Isospora spp. under field conditions.
authors: Bayer Animal Health GmbH, Leverkusen, Germany. gertraut.altreuther@bayer.com
authors: Gertraut
authors: G
authors: Altreuther
authors: Nadine
authors: N
authors: Gasda
authors: Kerstin
authors: K
authors: Adler
authors: Klaus
authors: K
authors: Hellmann
authors: Heloise
authors: H
authors: Thurieau
authors: Annette
authors: A
authors: Schimmel
authors: Douglas
authors: D
authors: Hutchens
authors: Klemens J
authors: KJ
authors: Krieger
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003049:Coccidiostats / Q000627:therapeutic use; D047630:Depsipeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004311:Double-Blind Method; D004338:Drug Combinations; D004341:Drug Evaluation; D005243:Feces / Q000469:parasitology; D007549:Isospora / Q000187:drug effects* / Q000472:pathogenicity; D021865:Isosporiasis / Q000188:drug therapy / Q000662:veterinary*; D018942:Macrolides / Q000627:therapeutic use; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D011223:Praziquantel / Q000627:therapeutic use; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000969:Antinematodal Agents; D003049:Coccidiostats; D047630:Depsipeptides; D004338:Drug Combinations; D018942:Macrolides; D014227:Triazines; C078973:milbemycin oxime; D011223:Praziquantel; C036670:toltrazuril; C468987:emodepside