title: The relationship between paraoxonase-1 activity and coronary artery disease in patients with metabolic syndrome.
abstract: OBJECTIVE
  We investigated the correlation of serum paraoxonase-1 (PON-1) activity with coronary artery disease (CAD) in patients with metabolic syndrome (MetS).
  
  
  METHODS
  The study included 21 patients (mean age 55 ± 9 years) with MetS, stable angina pectoris, and angiographically shown CAD, 24 patients (mean age 51 ± 10 years) with MetS and angiographically normal coroner arteries, and 28 healthy controls (mean age 49 ± 12 years). Demographic and clinical characteristics, insulin levels, homeostasis model assessment of insulin resistance index, and PON-1 activity were assessed in all the groups. Severity of CAD was assessed using the Gensini score.
  
  
  RESULTS
  Paraoxonase-1 activity was significantly lower in patients with MetS compared to the control group (p=0.02). The two MetS groups with and without CAD exhibited similar characteristics in all the parameters including PON-1 activity (p>0.05). Univariate correlation analysis performed in MetS-CAD patients showed a significant negative correlation between the Gensini score and PON-1 activity (r=-0.48, p=0.02). The overall PON-1 activity of all the subjects showed no correlation with the parameters examined.
  
  
  CONCLUSIONS
  Decreased PON-1 activity in patients with MetS compared to the control group suggests increased oxidative stress in MetS. Detection of similar PON-1 activity levels in MetS groups with and without CAD suggests that disturbance of oxidative-antioxidative balance occurs before the development of CAD. The negative correlation between the Gensini score and PON-1 activity implies that decreased PON-1 activity may be one of the etiologic causes of atherosclerotic progress in MetS.
authors: Department of Cardiology, Medicine Faculty of Mersin University, Mersin, Turkey. burakakcay2002@mynet.com
authors: Adnan Burak
authors: AB
authors: Akçay
authors: Ahmet
authors: A
authors: Camsarı
authors: Türkay
authors: T
authors: Ozcan
authors: Dilek
authors: D
authors: Ciçek
authors: Necdet
authors: N
authors: Akkuş
authors: Sabri
authors: S
authors: Seyis
authors: Burak
authors: B
authors: Cimen
authors: Barış
authors: B
authors: Celebi
authors: Oben
authors: O
authors: Döven
authors: Gökhan
authors: G
authors: Cin
mesh_terms: D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D043303:Aryldialkylphosphatase