title: Remodeling and repair of orthopedic tissue: role of mechanical loading and biologics: part II: cartilage and bone.
abstract: Orthopedic tissues respond to mechanical loads to maintain normal homeostasis and in response to injury. As the body of work on this continues to grow, it is important to synthesize the recent studies across tissues and specialties with one another and with past studies. Hence, this review highlights the knowledge gained since 2000, with only few exceptions, concerning the effects of mechanical load and biologics on remodeling and repair of orthopedic tissue.
authors: McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors: Chang Soo
authors: CS
authors: Lee
authors: Spencer E
authors: SE
authors: Szczesny
authors: Louis J
authors: LJ
authors: Soslowsky
mesh_terms: D001688:Biological Products / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D016723:Bone Remodeling / Q000187:drug effects / Q000502:physiology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D002358:Cartilage, Articular / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008023:Ligaments, Articular / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D008592:Menisci, Tibial / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D013314:Stress, Mechanical; D013710:Tendons / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D016474:Weight-Bearing
chemical_list: D001688:Biological Products