title: Neuropsychological correlates of the proportional impact of white matter hyperintensities on mild to moderate dementia: the MRI 300 study.
abstract: BACKGROUND
  White matter hyperintensities (WMH) increase cognitive impairment in patients with dementia.
  
  
  OBJECTIVE
  We investigated the impact of WMH on the neuropsychological profiles in patients with mild to moderate dementia.
  
  
  METHODS
  We consecutively recruited newly diagnosed patients with mild to moderate dementia across South Korea for 1 year. The participants completed neuropsychological tests, magnetic resonance imaging, and structured neurological evaluations. The patients were divided into 3 categories, i.e. minimal, moderate, and severe WMH groups, according to the proportional degree of WMH.
  
  
  RESULTS
  289 patients were recruited; 140 (48.3%) for the minimal WMH group, 99 (34.2%) for the moderate group, and 50 (17.5%) for the severe group. Both advanced age and low general cognitive level were significant contributors to WMH in patients with dementia. After adjusting for age, the neuropsychological correlates of the proportional impact of WMH were frontal executive, language, and attention profiles. However, the only significant neuropsychological correlate was the recognition memory profile after adjusting for both age and general cognitive level simultaneously.
  
  
  CONCLUSIONS
  The results suggest that the most significant neuropsychological profile impacting the burden of WMH in patients with mild to moderate dementia was the recognition memory profile, regardless of age and general cognitive function.
authors: Department of Neurology, College of Medicine, Kwandong University Myongji Hospital, Koyang, Korea.
authors: Bon D
authors: BD
authors: Ku
authors: Duk L
authors: DL
authors: Na
authors: So Young
authors: SY
authors: Moon
authors: Seong Yoon
authors: SY
authors: Kim
authors: Sang Won
authors: SW
authors: Seo
authors: Hae-Kwan
authors: HK
authors: Cheong
authors: Kyung Won
authors: KW
authors: Park
authors: Kee Hyung
authors: KH
authors: Park
authors: Jun-Young
authors: JY
authors: Lee
authors: Kyung Ryeol
authors: KR
authors: Cha
authors: Yong S
authors: YS
authors: Shim
authors: Young Chul
authors: YC
authors: Youn
authors: Chan-Seung
authors: CS
authors: Chung
authors: Jung Eun
authors: JE
authors: Kim
authors: Hee Young
authors: HY
authors: Kang
authors: Sang Yun
authors: SY
authors: Kim
authors: Seong Hye
authors: SH
authors: Choi
authors: Seol-Heui
authors: SH
authors: Han
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000523:psychology; D001921:Brain / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000473:pathology* / Q000523:psychology*; D003627:Data Interpretation, Statistical; D003704:Dementia / Q000473:pathology* / Q000523:psychology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004522:Educational Status; D056344:Executive Function; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009483:Neuropsychological Tests; D056910:Republic of Korea