title: Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis.
abstract: Jasmonate (JA) and ethylene (ET) are two major plant hormones that synergistically regulate plant development and tolerance to necrotrophic fungi. Both JA and ET induce the expression of several pathogenesis-related genes, while blocking either signaling pathway abolishes the induction of these genes by JA and ET alone or in combination. However, the molecular basis of JA/ET coaction and signaling interdependency is largely unknown. Here, we report that two Arabidopsis ET-stabilized transcription factors (EIN3 and EIL1) integrate ET and JA signaling in the regulation of gene expression, root development, and necrotrophic pathogen defense. Further studies reveal that JA enhances the transcriptional activity of EIN3/EIL1 by removal of JA-Zim domain (JAZ) proteins, which physically interact with and repress EIN3/EIL1. In addition, we find that JAZ proteins recruit an RPD3-type histone deacetylase (HDA6) as a corepressor that modulates histone acetylation, represses EIN3/EIL1-dependent transcription, and inhibits JA signaling. Our studies identify EIN3/EIL1 as a key integration node whose activation requires both JA and ET signaling, and illustrate transcriptional derepression as a common mechanism to integrate diverse signaling pathways in the regulation of plant development and defense.
authors: College of Life Sciences, Peking University, Beijing 100871, China.
authors: Ziqiang
authors: Z
authors: Zhu
authors: Fengying
authors: F
authors: An
authors: Ying
authors: Y
authors: Feng
authors: Pengpeng
authors: P
authors: Li
authors: Li
authors: L
authors: Xue
authors: Mu
authors: M
authors: A
authors: Zhiqiang
authors: Z
authors: Jiang
authors: Jong-Myong
authors: JM
authors: Kim
authors: Taiko Kim
authors: TK
authors: To
authors: Wei
authors: W
authors: Li
authors: Xinyan
authors: X
authors: Zhang
authors: Qiang
authors: Q
authors: Yu
authors: Zhi
authors: Z
authors: Dong
authors: Wen-Qian
authors: WQ
authors: Chen
authors: Motoaki
authors: M
authors: Seki
authors: Jian-Min
authors: JM
authors: Zhou
authors: Hongwei
authors: H
authors: Guo
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development / Q000378:metabolism* / Q000382:microbiology; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D020171:Botrytis / Q000472:pathogenicity; D003517:Cyclopentanes / Q000378:metabolism*; D018744:DNA, Plant / Q000235:genetics; D004268:DNA-Binding Proteins; D005030:Ethylenes / Q000378:metabolism*; D006655:Histone Deacetylases / Q000378:metabolism; D008954:Models, Biological; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D054883:Oxylipins / Q000378:metabolism*; D010937:Plant Growth Regulators / Q000378:metabolism*; D018517:Plant Roots / Q000254:growth & development / Q000378:metabolism; D030821:Plants, Genetically Modified; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D020798:Two-Hybrid System Techniques
chemical_list: D029681:Arabidopsis Proteins; D003517:Cyclopentanes; D018744:DNA, Plant; D004268:DNA-Binding Proteins; C494589:EIL1 protein, Arabidopsis; C106987:EIN3 protein, Arabidopsis; D005030:Ethylenes; D009687:Nuclear Proteins; D054883:Oxylipins; D010937:Plant Growth Regulators; D012097:Repressor Proteins; D014157:Transcription Factors; C011006:jasmonic acid; C036216:ethylene; C432452:AT5G63110 protein, Arabidopsis; D006655:Histone Deacetylases