title: Calcitonin use in giant cell bone tumors.
abstract: BACKGROUND
  As osteoclast, giant cell tumors express calcitonin receptors. The aim of this paper is to assess treatment using salmon calcitonin after curettage.
  
  
  METHODS
  We retrospectively reviewed 25 patients with giant cell tumor of the appendicular skeleton treated with a single protocol of calcitonin administration following curettage in order to assess the effectiveness of calcitonin in reducing the rate of local recurrence.
  
  
  RESULTS
  The mean duration follow-up was 68 months. Thirteen patients (52%) had local recurrence. Eight of them were treated successfully after repeated curettage and calcitonin. Four patients had bone resection and one patient had curettage and cement filling. All patients with cavity left empty had ossified and the functional score as assessed by the MSTS score was 28.02/30.
  
  
  CONCLUSIONS
  This study suggests that the use of calcitonin as adjuvant is not effective and that filling agents are not required after curettage of giant cell tumors.
  
  
  METHODS
  Level 4.
authors: Department of Adult Surgery, KASSAB's Institute Kassar Said, university Tunis el manar II, 2010 Mannouba Tunisia. nourihabib@yahoo.fr
authors: H
authors: H
authors: Nouri
authors: M
authors: M
authors: Hedi Meherzi
authors: M
authors: M
authors: Ouertatani
authors: M
authors: M
authors: Mestiri
authors: K
authors: K
authors: Zehi
authors: M
authors: M
authors: Douik
authors: M
authors: M
authors: Zouari
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000517:prevention & control* / Q000601:surgery; D002116:Calcitonin / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003475:Curettage; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000517:prevention & control* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D050071:Bone Density Conservation Agents; D002116:Calcitonin