title: ChREBP gene polymorphisms are associated with coronary artery disease in Han population of Hubei province.
abstract: BACKGROUND
  ChREBP regulates lipogenesis and glucose utilization in the liver. Current reports suggest a contradictive association between rs3812316 of this gene and triglyceride level. We hypothesized the polymorphisms in ChREBP gene were associated with CAD in Chinese population.
  
  
  METHODS
  The ChREBP gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods in 200 controls and 310 CAD patients. Serum lipids and glucose concentrations were measured in all subjects. Haplotypes were constructed based on rs3812316, rs7798357 and rs1051921. All the data were analyzed using SPSS14.0, PLINK1.07 and SHEsis software.
  
  
  RESULTS
  The rare allele G of rs3812316 was significantly lower in the CAD group after adjusting for age, sex, BMI, SBP and DBP (OR(a)=0.589, 95%CI=0.361-0.961, P=0.034). No significant differences between cases and controls were found in genotype or allele distributions of rs7798357, rs17145750 and rs1051921. Haplotype CGC was significant higher in CAD group (P<0.01, OR=2.364, 95%CI=1.608-3.474), while haplotypes GGC, CGT, CCC were significant lower in CAD group (P<0.05).
  
  
  CONCLUSIONS
  The rs3812316 and the haplotypes in ChREBP gene appeared to be related to high susceptibility to CAD.
authors: Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University, Hubei, China.
authors: Shuren
authors: S
authors: Guo
authors: Fang
authors: F
authors: Zheng
authors: Xueping
authors: X
authors: Qiu
authors: Na
authors: N
authors: Yang
mesh_terms: D000483:Alleles; D001483:Base Sequence; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics*; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D017931:DNA Primers; D005006:Ethnicity; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D017931:DNA Primers; C116385:MLXIPL protein, human