title: Induction of circulating monocyte chemoattractant protein-1 in women with gonadotropin-releasing hormone agonist.
abstract: The aim of the present study was to determine the influence of acute estrogen deficiency induced by administration of a gonadotropin-releasing hormone (GnRH) agonist on circulating levels of cytokines and chemokines. Eighty-three women with uterine leiomyoma were assigned in open, parallel-group fashion to a no-treatment (control) group and a GnRH-agonist group. Serum levels of nine cytokines and chemokines as well as vascular inflammatory markers were measured. Serum levels of monocyte chemoattractant protein (MCP)-1 and tumor necrosis factor-α (TNFα) in the GnRH-agonist group were increased significantly at 6 months. There were also significant differences in percentage changes in interleukin (IL)-6, IL8, MCP1, and macrophage inflammatory protein-1β (MIP1β) between the control and GnRH agonist groups. Soluble intercellular adhesion molecule-1 (sICAM1) and E-selectin levels showed significant increases in the GnRH agonist group at 6 months. Serum MCP1 concentrations showed weak correlations with levels of sICAM and E-selectin. We conclude that a hypo-estrogenic state due to administration of a GnRH agonist increases circulating levels of cytokines and chemokines, especially MCP1.
authors: Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan. sumika87@clin.med.tokushima-u.ac.jp
authors: Sumika
authors: S
authors: Matsui
authors: Toshiyuki
authors: T
authors: Yasui
authors: Hirokazu
authors: H
authors: Uemura
authors: Satoshi
authors: S
authors: Yamamoto
authors: Toshiya
authors: T
authors: Matsuzaki
authors: Naoko
authors: N
authors: Tsuchiya
authors: Mitsutoshi
authors: M
authors: Yuzurihara
authors: Yoshio
authors: Y
authors: Kase
authors: Minoru
authors: M
authors: Irahara
mesh_terms: D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D019040:E-Selectin / Q000097:blood*; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007889:Leiomyoma / Q000097:blood / Q000188:drug therapy; D016729:Leuprolide / Q000008:administration & dosage*; D013997:Time Factors; D014594:Uterine Neoplasms / Q000097:blood / Q000188:drug therapy
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D016207:Cytokines; D019040:E-Selectin; D005300:Fertility Agents, Female; D018799:Intercellular Adhesion Molecule-1; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide