title: Prognostic significance of leukopenia at the time of diagnosis in acute myeloid leukemia.
abstract: We investigated the clinical significance of leukopenia at the time of diagnosis in a cohort of 225 patients with newly diagnosed acute myeloid leukemia (AML) at a single institution. Leukocyte count was treated as a continuous variable and, using a receiver operating characteristic curve (ROC), a cutoff of 3,600/μL had the best sensitivity and specificity for remission (complete remission [CR]), relapse-free survival [RFS], and overall survival [OS]). In a multivariable model, leukopenia at diagnosis had no effects on CR (hazard ratio [HR] = 2.02; confidence interval [CI], 0.9-4.3; P = .07), RFS (HR = 0.93; CI, 0.5-1.5; P = .8), or OS (HR = 1.05; CI, 0.7-1.5; P = .7). No differential expression of cell surface molecules (CD34, c-Kit, CXCR4, PECAM, VLA2, VLA-, VLA4, VLA5, and FLT3) was observed on simultaneously obtained marrow and blood blasts in the high- vs. low-leukocyte groups. We conclude that leukopenia at diagnosis carries no prognostic significance in AML.
authors: Department of Hematology/Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
authors: Martha
authors: M
authors: Arellano
authors: Leon
authors: L
authors: Bernal-Mizrachi
authors: Lin
authors: L
authors: Pan
authors: Mourad
authors: M
authors: Tighiouart
authors: Liliana
authors: L
authors: Souza
authors: Xiangxue
authors: X
authors: Guo
authors: Morgan
authors: M
authors: McLemore
authors: Lisa
authors: L
authors: Lima
authors: Susan
authors: S
authors: Sunay
authors: Leonard T
authors: LT
authors: Heffner
authors: Zhengjia
authors: Z
authors: Chen
authors: Georgia Zhou
authors: GZ
authors: Chen
authors: Amelia
authors: A
authors: Langston
authors: Elliott
authors: E
authors: Winton
authors: H Jean
authors: HJ
authors: Khoury
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015815:Cell Adhesion Molecules / Q000378:metabolism; D015331:Cohort Studies; D060830:Consolidation Chemotherapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D007970:Leukopenia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015815:Cell Adhesion Molecules