title: Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice.
abstract: Anti-inflammatory and analgesic activity of protocatechuic acid (PCA), a natural product, was evaluated in different rat models (viz., carrageenan-induced paw oedema, cotton pellet-induced granuloma and Freund's adjuvant arthritis) of inflammation and chemical and heat induced mouse models of pain. Treatment with PCA inhibited significantly different biological parameters like hind paw oedema, granuloma exudates formation and arthritis index in carrageenan oedema, cotton pellet granuloma and Freund's adjuvant arthritis, respectively. The biochemical changes viz., glutathione, superoxide dismutase, catalase, lipid peroxidation and NO in oedematous or in liver tissues and serum alanine aminotransferase and lactic dehydrogenase occurred during different types of inflammation were either significantly restored or inhibited with PCA pretreatment. Present experimental findings demonstrate promising anti-inflammatory and analgesic activity of PCA which is comparable with that of standard drugs used.
authors: Department of Pharmacology, Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, 411 018, India.
authors: Amol B
authors: AB
authors: Lende
authors: Ajay D
authors: AD
authors: Kshirsagar
authors: Avinash D
authors: AD
authors: Deshpande
authors: Milind M
authors: MM
authors: Muley
authors: Rajesh Ramesh
authors: RR
authors: Patil
authors: Pallavi A
authors: PA
authors: Bafna
authors: Suresh R
authors: SR
authors: Naik
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan / Q000633:toxicity; D002374:Catalase / Q000378:metabolism; D004008:Diclofenac / Q000494:pharmacology / Q000633:toxicity; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D005620:Freund's Adjuvant / Q000633:toxicity; D005978:Glutathione / Q000378:metabolism; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D062385:Hydroxybenzoates / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D011920:Rats, Inbred WF; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D062385:Hydroxybenzoates; D004008:Diclofenac; D009569:Nitric Oxide; C009091:protocatechuic acid; D002351:Carrageenan; D005620:Freund's Adjuvant; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D019342:Acetic Acid