title: Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids.
abstract: A series of synthesized novel biscoumarin-chalcone hybrids were evaluated for their anti-inflammatory and antioxidant activity. The tested compounds significantly inhibit the carrageenin induced paw oedema in albino rats and also exhibit important scavenging activities. These compounds thus constitute an interesting template for the design of new therapeutic tools against inflammation.
authors: Medicinal and Process Chemistry Division, Central Drug Research Institute (CSIR-CDRI), Lucknow, India. sashidhar123@gmail.com
authors: Koneni V
authors: KV
authors: Sashidhara
authors: Manoj
authors: M
authors: Kumar
authors: Ram K
authors: RK
authors: Modukuri
authors: Ravi
authors: R
authors: Sonkar
authors: Gitika
authors: G
authors: Bhatia
authors: A K
authors: AK
authors: Khanna
authors: Shivika
authors: S
authors: Rai
authors: Rakesh
authors: R
authors: Shukla
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002599:Chalcone / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D004487:Edema / Q000188:drug therapy; D008861:Microsomes / Q000378:metabolism; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003374:Coumarins; D002599:Chalcone; C030123:coumarin