title: [Imaging biomarkers, quantitative imaging, and bioengineering].
abstract: Imaging biomarkers define objective characteristics extracted from medical images that are related to normal biological processes, diseases, or the response to treatment. To develop an imaging biomarker, it is necessary to carry out a series of steps to validate its relation with the reality studied and to check its clinical and technical validity. This process includes defining tests for the concepts and mechanisms; obtaining standardized and optimized anatomic, functional, and molecular images; analyzing the data with computer models; displaying data appropriately; obtaining the appropriate statistic measures; and conducting tests on the principle, efficacy, and effectiveness. In this article, we aim to explain the steps that must be established to enable biomarkers to be correctly applied, from their theoretical conception to their clinical implementation. To this end, we use the evaluation of angiogenesis in articular cartilage as an example.
authors: Servicio de Radiología, Hospital Quirón Valencia, Valencia, España. Luis.Marti@uv.es
authors: L
authors: L
authors: Martí Bonmatí
authors: A
authors: A
authors: Alberich-Bayarri
authors: G
authors: G
authors: García-Martí
authors: R
authors: R
authors: Sanz Requena
authors: C
authors: C
authors: Pérez Castillo
authors: J M
authors: JM
authors: Carot Sierra
authors: J V
authors: JV
authors: Manjón Herrera
mesh_terms: D057005:Bioengineering; D003952:Diagnostic Imaging / Q000379:methods*; D005069:Evaluation Studies as Topic; D006801:Humans; D054928:Validation Studies as Topic