title: Knee chondral injuries: clinical treatment strategies and experimental models.
abstract: Articular cartilage has a very limited capacity to repair and as such premature joint degeneration is often the end point of articular injuries. Patients with chondral injury have asymptomatic periods followed by others in which discomfort or pain is bearable. The repair of focal cartilage injuries requires a precise diagnosis, a completed knee evaluation to give the correct indication for surgery proportional to the damage and adapted to each patient. Many of the surgical techniques currently performed involve biotechnology. The future of cartilage repair should be based on an accurate diagnosis using new MRI techniques. Clinical studies would allow us to establish the correct indications and surgical techniques implanting biocompatible and biodegradable matrices with or without stem cells and growth factors. Arthroscopic techniques with the design of new instruments can facilitate repair of patella and tibial plateau lesions.
authors: Hospital Gregorio Marañon, Orthopaedic Surgery Department, Madrid, Spain.
authors: Javier
authors: J
authors: Vaquero
authors: Francisco
authors: F
authors: Forriol
mesh_terms: D000818:Animals; D001182:Arthroscopy / Q000379:methods*; D002358:Cartilage, Articular / Q000473:pathology / Q000601:surgery*; D019902:Chondrocytes / Q000637:transplantation*; D003646:Debridement; D006041:Goats; D006801:Humans; D007718:Knee Injuries / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D007719:Knee Joint / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D051379:Mice; D023421:Models, Animal; D016348:Osseointegration; D012756:Sheep; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D016896:Treatment Outcome