title: Up-regulation of p21-activated kinase 1 by in vitro treatment with interleukin 1-beta and its increased expression in ovarian endometriotic cysts.
abstract: We evaluated whether the proinflammatory cytokines can regulate p21-activated kinase (Pak1) expression in endometrial cells as well as whether its expression is increased in endometriotic cysts. We found that interleukin-1β up-regulates Pak1 expression in endometrial stromal cells (ESC) and that the immunoreactivity of Pak1 is increased in the endometriotic cysts.
authors: Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
authors: Mi Young
authors: MY
authors: Lee
authors: Sung Hoon
authors: SH
authors: Kim
authors: Hyo Jin
authors: HJ
authors: Ihm
authors: Hee Dong
authors: HD
authors: Chae
authors: Chung-Hoon
authors: CH
authors: Kim
authors: Byung Moon
authors: BM
authors: Kang
mesh_terms: D000293:Adolescent; D000328:Adult; D015153:Blotting, Western; D016022:Case-Control Studies; D045744:Cell Line, Tumor; D004715:Endometriosis / Q000201:enzymology* / Q000473:pathology; D004717:Endometrium / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053583:Interleukin-1beta / Q000494:pharmacology*; D010048:Ovarian Cysts / Q000201:enzymology* / Q000473:pathology; D056910:Republic of Korea; D017154:Stromal Cells / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D015854:Up-Regulation; D055815:Young Adult; D054462:p21-Activated Kinases / Q000378:metabolism*
chemical_list: D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; C515903:PAK1 protein, human; D054462:p21-Activated Kinases