title: Coffee consumption may influence hippocampal volume in young women.
abstract: Caffeine is the most often used psychoactive substance. Caffeine may influence neuroplasticity in animals. We investigated the relationship between caffeine intake (coffee consumption) and brain morphology. Forty-five healthy, non-smoking women aged 19-30 were included in the present study. We used semi-automatic user-independent MR volumetry and voxel-based morphometry. We investigated the relationship between caffeine intake (coffee consumption) and the volumes of the cortical brain structures where caffeine is supposed to act. We found that high-level and low-level caffeine intake was associated with a larger hippocampus compared to moderate-level caffeine intake. The other brain structures showed no association with coffee consumption or caffeine intake. The U-shape association between caffeine concentration and its effect has already been described in some experimental studies. To our knowledge this is one of the very first studies, which tries to find an association between brain morphology and coffee consumption or caffeine intake in humans using MR imaging.
authors: Department of Neurology, University of Pécs, Rét u. 2., 7623 Pecs, Hungary.
authors: Gabor
authors: G
authors: Perlaki
authors: Gergely
authors: G
authors: Orsi
authors: Norbert
authors: N
authors: Kovacs
authors: Attila
authors: A
authors: Schwarcz
authors: Zilia
authors: Z
authors: Pap
authors: Zsuzsanna
authors: Z
authors: Kalmar
authors: Eniko
authors: E
authors: Plozer
authors: Arpad
authors: A
authors: Csatho
authors: Robert
authors: R
authors: Gabriel
authors: Samuel
authors: S
authors: Komoly
authors: Imre
authors: I
authors: Janszky
authors: József
authors: J
authors: Janszky
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology; D003069:Coffee; D004305:Dose-Response Relationship, Drug; D005260:Female; D006257:Head / Q000033:anatomy & histology; D006624:Hippocampus / Q000033:anatomy & histology* / Q000187:drug effects*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D055815:Young Adult
chemical_list: D003069:Coffee