title: Structure-activity studies of RNA-binding oxazolidinone derivatives.
abstract: The structure-activity relationship of a series of oxazolidinones binding to T-box riboswitch antiterminator RNA has been investigated. Oxazolidinones differentially substituted at C-5 were prepared and the ligand-induced fluorescence resonance energy transfer (FRET) changes in FRET-labeled antiterminator model RNA were assayed. Both qualitative and quantitative analysis of the structure-activity relationship indicate that hydrogen bonding and hydrophobic properties play a significant role in ligand binding.
authors: Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA.
authors: Iwona
authors: I
authors: Maciagiewicz
authors: Shu
authors: S
authors: Zhou
authors: Stephen C
authors: SC
authors: Bergmeier
authors: Jennifer V
authors: JV
authors: Hines
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D009690:Nucleic Acid Conformation; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry*; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D058928:Riboswitch; D013329:Structure-Activity Relationship
chemical_list: D023303:Oxazolidinones; D058928:Riboswitch; D012313:RNA