title: Body mass index increase, serum leptin, adiponectin, neuropeptide Y and lipid levels during treatment with olanzapine and haloperidol.
abstract: BACKGROUND
  Body mass index (BMI) increase is an undesired effect associated with antipsychotics, and crucial for patients' global health and treatment compliance. We aimed to investigate the relation between BMI during olanzapine or haloperidol treatments and leptin, neuropeptide Y (NPY), adiponectin and lipid serum levels.
  
  
  METHODS
  In this 9-month, randomized and naturalist study, 34 male patients, 18 on olanzapine and 16 on haloperidol group were enrolled, all were under monotherapy. Patient outcome was evaluated with positive and negative syndrome scale (PANSS) at every 3-month period. In each visit, BMI, leptin, NPY, lipid, olanzapine or haloperidol levels were also monitored.
  
  
  CONCLUSIONS
  Leptin levels positively correlated with BMI in olanzapine (r=0.64, p<0.001) and haloperidol (r=0.73, p<0.001) groups; only in olanzapine patients, the former also correlated with PANSS score (r=0.54, p<0.05). NPY levels negatively correlated with olanzapine levels (r=− 0.65, p<0.01). Adiponectin levels had not significantly varied.
  
  
  CONCLUSIONS
  Antipsychotics probably interfere on leptin and NPY signalling ways and disturb these hormones in eating behaviour control.
authors: Laboratory of Neuroscience (LIM 27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo , São Paulo/SP , Brazil. nadiafox@gmail.com
authors: N R B
authors: NR
authors: Raposo
authors: A S
authors: AS
authors: Ferreira
authors: W F
authors: WF
authors: Gattaz
mesh_terms: D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000097:blood; D001569:Benzodiazepines / Q000009:adverse effects* / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D006220:Haloperidol / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood; D000077152:Olanzapine; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D052242:Adiponectin; D014150:Antipsychotic Agents; D015415:Biomarkers; D020738:Leptin; D008055:Lipids; D009478:Neuropeptide Y; D001569:Benzodiazepines; D006220:Haloperidol; D000077152:Olanzapine