title: Sensitivity to secondhand smoke exposure predicts future smoking susceptibility.
abstract: OBJECTIVE
  Susceptibility to cigarette smoking in tobacco-naive youth is a strong predictor of smoking initiation. Identifying mechanisms that contribute to smoking susceptibility provide information about early targets for smoking prevention. This study investigated whether sensitivity to secondhand smoke exposure (SHSe) contributes to smoking susceptibility.
  
  
  METHODS
  Subjects were high-risk, ethnically diverse 8- to 13-year-old subjects who never smoked and who lived with at least 1 smoker and who participated in a longitudinal SHSe reduction intervention trial. Reactions (eg, feeling dizzy) to SHSe were assessed at baseline, and smoking susceptibility was assessed at baseline and 3 follow-up measurements over 12 months. We examined the SHSe reaction factor structure, association with demographic characteristics, and prediction of longitudinal smoking susceptibility status.
  
  
  RESULTS
  Factor analysis identified "physically unpleasant" and "pleasant" reaction factors. Reported SHSe reactions did not differ across gender or family smoking history. More black preteens reported feeling relaxed and calm, and fewer reported feeling a head rush or buzz compared with non-Hispanic white and Hispanic white counterparts. Longitudinally, 8.5% of subjects tracked along the trajectory for high (versus low) smoking susceptibility. Reporting SHSe as "unpleasant or gross" predicted a 78% reduction in the probability of being assigned to the high-smoking susceptibility trajectory (odds ratio: 0.22 [95% confidence interval: 0.05-0.95]), after covariate adjustment.
  
  
  CONCLUSIONS
  Assessment of SHSe sensitivity is a novel approach to the study of cigarette initiation etiology and informs prevention interventions.
authors: Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA. schlaggc@psychiatry.wustl.edu
authors: Christina N
authors: CN
authors: Lessov-Schlaggar
authors: Dennis R
authors: DR
authors: Wahlgren
authors: Sandy
authors: S
authors: Liles
authors: Ming
authors: M
authors: Ji
authors: Suzanne C
authors: SC
authors: Hughes
authors: Jonathan P
authors: JP
authors: Winickoff
authors: Jennifer A
authors: JA
authors: Jones
authors: Gary E
authors: GE
authors: Swan
authors: Melbourne F
authors: MF
authors: Hovell
mesh_terms: D000293:Adolescent; D002648:Child; D003371:Cough / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D003430:Cross-Sectional Studies; D004244:Dizziness / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009325:Nausea / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D012307:Risk Factors; D012907:Smoking / Q000503:physiopathology / Q000523:psychology*; D016540:Smoking Cessation / Q000379:methods* / Q000523:psychology*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D014028:Tobacco Smoke Pollution