title: Effect of 4-methyl-3-nitrobenzoic acid on non‑small cell lung cancer cell migration.
abstract: Metastasis is a major cause of mortality among lung cancer patients. In a previous high-throughput screening of 20,000 compounds to identify inhibitors of cancer cell migration, 4-methyl-3-nitrobenzoic acid was found to inhibit the migration of nine tumor cell lines. The present study used the human non-small cell lung cancer cell (NSCLC) treatment with 4-methyl-3-nitrobenzoic acid significantly inhibited epithelial growth factor (EGF)-induced chemotaxis and chemokinesis of cancer cells in NSCLC cells. The defect in chemotaxis is likely due to the impairment in EGF-induced cofilin phosphorylation and actin polymerization. Furthermore, EGF-induced cell adhesion, which is another key factor in cell migration, was also inhibited. Taken together, these results suggest that 4-methyl-3-nitrobenzoic acid is a potent inhibitor of cancer cell chemotaxis and may be developed into a novel antimetastasis drug.
authors: Tianjin Medical University, Cancer Institute and Hospital, Research Center for Basic Medical Science, Heping, Tianjin 300070, P.R. China.
authors: Peng
authors: P
authors: Chen
authors: Xiaofang
authors: X
authors: Zhang
authors: Hua
authors: H
authors: Guo
authors: Ning
authors: N
authors: Ma
authors: Menghui
authors: M
authors: Li
authors: Zhe
authors: Z
authors: Liu
authors: Ning
authors: N
authors: Zhang
authors: Xishan
authors: X
authors: Hao
mesh_terms: D000199:Actins / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D002633:Chemotaxis / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000494:pharmacology; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D009579:Nitrobenzoates / Q000737:chemistry / Q000494:pharmacology*; D058105:Polymerization / Q000187:drug effects
chemical_list: C558412:4-methyl-3-nitrobenzoic acid; D000199:Actins; D009579:Nitrobenzoates; D004815:Epidermal Growth Factor