title: Progress and challenges in the study of α6-containing nicotinic acetylcholine receptors.
abstract: Recent progress has been made in the understanding of the anatomical distribution, composition, and physiological role of nicotinic acetylcholine receptors containing the α6 subunit. Extensive study by many researchers has indicated that a collection of α6-containing receptors representing a nicotinic sub-family is relevant in preclinical models of nicotine self-administration and locomotor activity. Due to a number of technical difficulties, the state of the art of in vitro model systems expressing α6-containing receptors has lagged behind the state of knowledge of native α6 nAChR subunit composition. Several techniques, such as the expression of chimeric and concatameric α6 subunit constructs in oocytes and mammalian cell lines have been employed to overcome these obstacles. There remains a need for other critical tools, such as selective small molecules and radioligands, to advance the field of research and to allow the discovery and development of potential therapeutics targeting α6-containing receptors for smoking cessation, Parkinson's disease and other disorders.
authors: Targacept, Inc., 200 East First Street, Suite 300, Winston-Salem, NC 27101-4165, United States. sharon.letchworth@targacept.com
authors: Sharon R
authors: SR
authors: Letchworth
authors: Paul
authors: P
authors: Whiteaker
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods / Q000639:trends; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D021122:Protein Subunits; D011978:Receptors, Nicotinic / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology
chemical_list: D008024:Ligands; D021122:Protein Subunits; D011978:Receptors, Nicotinic; D054852:Small Molecule Libraries; C559463:alpha6beta2 nicotinic acetylcholine receptor