title: A case of confined placental mosaicism with double trisomy associated with stillbirth.
abstract: We present a case of stillbirth in which the fetus was well grown and karyotypically normal, but the placenta was morphologically abnormal and had confined placental mosaicism (CPM) for a double trisomy of chromosomes 12 and 15. A compilation of published cases of CPM reveals that whilst approximately 80% of pregnancies progress normally, there is an association with abnormal placental morphology, intrauterine growth restriction, fetal abnormalities and stillbirth. This case highlights the potential adverse effects of CPM and the benefit of placental examination in determining the cause of stillbirth.
authors: Maternal and Fetal Health Research Centre, Manchester Academic Health Sciences Centre, 5th floor (Research), St Mary's Hospital, Oxford Road, Manchester M13 9WL, UK. Electronic address: laurargoodfellow@doctors.org.uk.
authors: L R
authors: LR
authors: Goodfellow
authors: Department of Paediatric and Perinatal Pathology, Central Manchester University Hospitals Foundation Trust, Manchester, UK.
authors: G
authors: G
authors: Batra
authors: Department of Obstetrics and Gynaecology, Macclesfield District General Hospital, Macclesfield, UK.
authors: V
authors: V
authors: Hall
authors: Department of Cytogenetics, Central Manchester University Hospitals Foundation Trust, Manchester, UK.
authors: E
authors: E
authors: McHale
authors: Maternal and Fetal Health Research Centre, Manchester Academic Health Sciences Centre, 5th floor (Research), St Mary's Hospital, Oxford Road, Manchester M13 9WL, UK.
authors: A E P
authors: AEP
authors: Heazell
mesh_terms: D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D005260:Female; D006801:Humans; D009030:Mosaicism; D010922:Placenta Diseases / Q000235:genetics* / Q000473:pathology; D011247:Pregnancy; D050497:Stillbirth / Q000235:genetics*; D014314:Trisomy