title: [Successful interferon-alpha therapy of renal cell carcinoma with lung metastasis: a case report].
abstract: A 67-year-old man was admitted with a chief complaint of dyspnea. Computed tomography (CT) revealed a left renal tumor, 12 cm in diameter, with tumor thrombus in the left renal vein, multiple lung metastases, right pleural effusion, and para-aortic lymph node metastases. Because of poor condition in respiratory status, nephrectomy was considered to be impossible and the patient was administered 6×10⁶ IU of interferon-alpha daily. Then, 6×10⁶ IU was also administered three times a week. At 14 months after interferon-alpha therapy, CT scan showed complete remission of lung, pleura metastases and right pleural effusion, and the left renal tumor was markedly reduced in size. Because of improvement of general condition, nephrectomy of the left kidney was performed. Twenty-seven months after the start of interferon-alpha therapy, the patient is alive without evidence of disease.
authors: The Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama.
authors: Keisuke
authors: K
authors: Ichimatsu
authors: Akihiro
authors: A
authors: Morii
authors: Akihiko
authors: A
authors: Watanabe
authors: Kenji
authors: K
authors: Yasuda
authors: Akira
authors: A
authors: Komiya
authors: Hideki
authors: H
authors: Fuse
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male
chemical_list: D016898:Interferon-alpha