title: The roles of viruses in brain tumor initiation and oncomodulation.
abstract: While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.
authors: Department of Microbiology, University of Virginia, P.O. Box 800168, Charlottesville, VA 22908, USA.
authors: Alexander
authors: A
authors: Kofman
authors: Lucasz
authors: L
authors: Marcinkiewicz
authors: Evan
authors: E
authors: Dupart
authors: Anton
authors: A
authors: Lyshchev
authors: Boris
authors: B
authors: Martynov
authors: Anatolii
authors: A
authors: Ryndin
authors: Elena
authors: E
authors: Kotelevskaya
authors: Jay
authors: J
authors: Brown
authors: David
authors: D
authors: Schiff
authors: Roger
authors: R
authors: Abounader
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000821:virology*; D002472:Cell Transformation, Viral / Q000502:physiology*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000821:virology*; D012190:Retroviridae / Q000502:physiology*; D014412:Tumor Virus Infections / Q000150:complications*