title: Interaction of 5-HTTLPR and idiographic stressors predicts prospective depressive symptoms specifically among youth in a multiwave design.
abstract: 5-HTTLPR, episodic stressors, depressive and anxious symptoms were assessed prospectively (child and parent report) every 3 months over 1 year (5 waves of data) among community youth ages 9 to 15 (n = 220). Lagged hierarchical linear modeling analyses showed 5-HTTLPR interacted with idiographic stressors (increases relative to the child's own average level over time), but not nomothetic stressors (higher stress exposure relative to the sample), to predict prospective elevations in depressive, but not anxious, symptoms. Youth with copies of the S or L(G) alleles of 5-HTTLPR, who experienced more stressors relative to their typical level, exhibited prospective increases in depressive symptoms over time. These findings suggest that 5-HTTLPR confers susceptibility to depression via stress reactivity.
authors: Department of Psychology, University of Denver, CO 80208, USA. ben.hankin@psy.du.edu
authors: Benjamin L
authors: BL
authors: Hankin
authors: Jessica
authors: J
authors: Jenness
authors: John R Z
authors: JR
authors: Abela
authors: Andrew
authors: A
authors: Smolen
mesh_terms: D000293:Adolescent; D000483:Alleles; D002648:Child; D003863:Depression / Q000209:etiology* / Q000235:genetics / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000523:psychology; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D008297:Male; D011110:Polymorphism, Genetic / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics / Q000502:physiology*; D012737:Sex Factors; D013315:Stress, Psychological / Q000209:etiology* / Q000235:genetics / Q000523:psychology; D011795:Surveys and Questionnaires
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins