title: Efficacy of a 0.0584% hydrocortisone aceponate spray in presumed feline allergic dermatitis: an open label pilot study.
abstract: This study evaluated the efficacy of a 0.0584% hydrocortisone aceponate (HCA) spray (Cortavance(®); Virbac SA) in 10 cats with presumed allergic dermatitis. The cats initially received two sprays/100 cm(2) of skin once daily. Clinical lesions (a Feline Dermatitis Extent and Severity Index; FeDESI), pruritus (10 cm visual analog scale with grade descriptors) and owner assessments of efficacy, tolerance and ease of use (from 1=very poor to 5=excellent) were assessed every 14 days. The frequency of treatment was reduced after day 28 in cats with a >50% reduction in FeDESI and pruritus scores. One cat was lost to follow up at day 28 and two at day 42. Intention-to-treat data were analysed. The FeDESI [mean (SD): day 0, 42.2 (15.7) and day 56, 9.9 (11.7); P<0.0001] and pruritus scores [day 0, 61.2 mm (20.1) and day 56, 14.6 mm (16.1); P<0.0001] significantly decreased throughout the trial. The owner scores for tolerance [median (range): day 14, 4 (1-5) and day 56, 4 (3-5); P=0.003] and ease of administration [day 14, 3 (2-5) and day 56, 4 (2-5); P=0.02] significantly increased during the trial, but there was no significant change in efficacy scores [day 14, 4 (3-5) and day 56, 4 (2-5); P=0.5]. There were no adverse effects attributable to the HCA spray, no significant changes in weight [mean (SD): day 0, 5.0 kg (1.4) and day 56, 5.0 kg (1.6); P=0.51] and no significant changes in haematology, biochemistry or urinalysis (n=4). Six cats required every-other-day treatment and four required daily treatment. In conclusion, HCA spray appeared to be effective and safe in these cats, although it is not licensed for use in this species.
authors: School of Veterinary Science, The University of Liverpool, Leahurst, Cheshire CH64 7TE, UK.
authors: Vanessa
authors: V
authors: Schmidt
authors: Laura M
authors: LM
authors: Buckley
authors: Neil A
authors: NA
authors: McEwan
authors: Christophe A
authors: CA
authors: Rème
authors: Tim J
authors: TJ
authors: Nuttall
mesh_terms: D000336:Aerosols; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy / Q000662:veterinary*; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006854:Hydrocortisone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D056687:Off-Label Use / Q000662:veterinary; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D003879:Dermatologic Agents; C063919:hydrocortisone aceponate; D006854:Hydrocortisone