title: Permeability of anti-fouling PEGylated surfaces probed by fluorescence correlation spectroscopy.
abstract: The present work reports on in situ observations of the interaction of organic dye probe molecules and dye-labeled protein with different poly(ethylene glycol) (PEG) architectures (linear, dendron, and bottle brush). Fluorescence correlation spectroscopy (FCS) and single molecule event analysis were used to examine the nature and extent of probe-PEG interactions. The data support a sieve-like model in which size-exclusion principles determine the extent of probe-PEG interactions. Small probes are trapped by more dense PEG architectures and large probes interact more with less dense PEG surfaces. These results, and the tunable pore structure of the PEG dendrons employed in this work, suggest the viability of electrochemically-active materials for tunable surfaces.
authors: Department of Chemistry, Rice University, Houston, TX 77251, United States.
authors: Charlisa R
authors: CR
authors: Daniels
authors: Carmen
authors: C
authors: Reznik
authors: Rachel
authors: R
authors: Kilmer
authors: Mary Jane
authors: MJ
authors: Felipe
authors: Maria Celeste R
authors: MC
authors: Tria
authors: Katerina
authors: K
authors: Kourentzi
authors: Wen-Hsiang
authors: WH
authors: Chen
authors: Rigoberto C
authors: RC
authors: Advincula
authors: Richard C
authors: RC
authors: Willson
authors: Christy F
authors: CF
authors: Landes
mesh_terms: D008958:Models, Molecular; D011092:Polyethylene Glycols / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013499:Surface Properties
chemical_list: D011092:Polyethylene Glycols