title: Arginase inhibitor in the pharmacological correction of endothelial dysfunction.
abstract: THIS PAPER IS ABOUT A WAY OF CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH THE INHIBITOR OF ARGINASE: L-norvaline. There is an imbalance between vasoconstriction and vasodilatation factors of endothelium on the basis of endothelial dysfunction. Among vasodilatation agents, nitrogen oxide plays the basic role. Amino acid L-arginine serves as a source of molecules of nitrogen oxide in an organism. Because of the high activity of arginase enzyme which catalyzes the hydrolysis of L-arginine into ornithine and urea, the bioavailability of nitrogen oxide decreases. The inhibitors of arginase suppress the activity of the given enzyme, raising and production of nitrogen oxide, preventing the development of endothelial dysfunction.
authors: Department of Pharmacology and Pharmaceutical Sciences, Belgorod State University, 85 Pobeda Street, Belgorod 308015, Russia.
authors: Mihail V
authors: MV
authors: Pokrovskiy
authors: Mihail V
authors: MV
authors: Korokin
authors: Svetlana A
authors: SA
authors: Tsepeleva
authors: Tatyana G
authors: TG
authors: Pokrovskaya
authors: Vladimir V
authors: VV
authors: Gureev
authors: Elena A
authors: EA
authors: Konovalova
authors: Oleg S
authors: OS
authors: Gudyrev
authors: Vladimir I
authors: VI
authors: Kochkarov
authors: Liliya V
authors: LV
authors: Korokina
authors: Eleonora N
authors: EN
authors: Dudina
authors: Anna V
authors: AV
authors: Babko
authors: Elena G
authors: EG
authors: Terehova