title: Consumption of lycopene inhibits the growth and progression of colon cancer in a mouse xenograft model.
abstract: A previous study indicated that lycopene could significantly inhibit the proliferation of human colon cancer cells in vitro. However, the in vivo anticancer effects of lycopene against colon cancer have not been demonstrated yet. Therefore, this study investigated whether consumption of lycopene could prevent the growth and progression of colorectal tumor in a mouse xenograft model. Bioluminescence imaging, histopathological, immunofluorescence (IFC), and immunohistochemical (IHC) staining results indicated that lycopene could effectively suppress the growth and progression of colon cancer in tumor-bearing mice. The results demonstrated that lycopene significantly suppressed the nuclear expression of PCNA and β-catenin proteins in tumor tissues. Consumption of lycopene could also augment the E-cadherin adherent molecule and nuclear levels of cell cycle inhibitor p21(CIP1/WAF1) protein. The chemopreventive effects of lycopene were associated with suppression of COX-2, PGE(2), and phosphorylated ERK1/2 proteins. Furthermore, the inhibitory effects of lycopene were inversely correlated with the plasma levels of matrix metalloproteinase 9 (MMP-9) in tumor-bearing mice. These results suggested that lycopene could act as a chemopreventive agent against the growth and progression of colorectal cancer in a mouse xenograft model.
authors: Biomedical Science Laboratory, Department of Nutrition, China Medical University, Taichung, Taiwan, Republic of China. vincenttang@mail.cmu.edu.tw
authors: Feng-Yao
authors: FY
authors: Tang
authors: Man-Hui
authors: MH
authors: Pai
authors: Xiang-Dong
authors: XD
authors: Wang
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D017209:Apoptosis; D002338:Carotenoids / Q000008:administration & dosage*; D003110:Colonic Neoplasms / Q000473:pathology*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics; D004032:Diet; D005260:Female; D019073:HT29 Cells; D006801:Humans; D000077276:Lycopene; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous
chemical_list: D016588:Anticarcinogenic Agents; D050759:Cyclin-Dependent Kinase Inhibitor p21; D002338:Carotenoids; D020780:Matrix Metalloproteinase 9; D000077276:Lycopene