title: Evaluation of natural reductants protecting red blood cell membranes against oxidative damage in psoriatic patients.
abstract: OBJECTIVE
  Psoriasis is a chronic skin disease and one of its main causes could be the oxidative stress. The use of natural reductants, in the treatment of several diseases, is well known but the effects of such treatments on the chronic psoriasis are not clear. The aim of this study is to evaluate the efficacy of the treatment with organic matrix, deriving from micro-flora, grown in shallow hyper thermal water tubs at Guardia Piemontese-Acquappesa (CS) Italy, in patients affected by moderate psoriasis.
  
  
  METHODS
  The study has been performed on 10 subjects with plaque psoriasis and on 10 healthy control subjects. Clinical severity of psoriasis was determined according to Psoriasis and Severity Index (PASI). The treatment efficacy was observed trough the evaluation of membrane fluidity, by fluorescence polarization, lipid peroxidation, anion permeability and haemolysis in red blood cells.
  
  
  RESULTS
  After 12 days of patients' treatment, a significant reduction of PASI score was observed, this result is supported by a significant improvement of all studied parameters.
  
  
  CONCLUSIONS
  The results, obtained by the evaluation of all studied parameters in patients treated with the organic matrix, are evidence of the efficacy of this treatment, according to PASI evaluation. Thus our results, suggest that this therapeutic line may be useful in the treatment of moderate psoriatic lesions and also in improving the life quality of psoriatic patients.
authors: Department of Cell Biology, University of Calabria, Italy. mazzulla@unical.it
authors: S
authors: S
authors: Mazzulla
authors: S
authors: S
authors: Sesti
authors: A
authors: A
authors: Martini
authors: V
authors: V
authors: Nicoletta
authors: S
authors: S
authors: De Stefano
authors: M
authors: M
authors: Morrone
authors: G
authors: G
authors: Martino
mesh_terms: D000328:Adult; D000368:Aged; D001688:Biological Products / Q000627:therapeutic use*; D002462:Cell Membrane; D004912:Erythrocytes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008900:Mineral Waters; D018384:Oxidative Stress; D011565:Psoriasis / Q000097:blood / Q000378:metabolism / Q000628:therapy*; D019163:Reducing Agents / Q000627:therapeutic use*
chemical_list: D001688:Biological Products; D008900:Mineral Waters; D019163:Reducing Agents