title: Does cerebral small vessel disease predict future decline of cognitive function in elderly people with type 2 diabetes?
abstract: OBJECTIVE
  We conducted a 3-year longitudinal study concerning an association between cognitive function and cerebral small vessel disease (SVD) seen on magnetic resonance imaging (MRI) in elderly type 2 diabetic patients.
  
  
  METHODS
  Four cognitive function tests--MMSE, word recall, Digit Symbol Substitution (DSS), and Stroop Color Word (Stroop)--were performed in 67 diabetic patients twice in 2006 and 2009. SVD was diagnosed as silent brain infarct (SBI) and white matter lesions (WMLs) according to MRI.
  
  
  RESULTS
  Number of SBI was significantly correlated with a decline in DSS and Stroop tests, while WMLs grade was only associated with it in DSS tests after adjustment for age, gender, education years, the presence of hypertension and dyslipidemia, and smoking. Severity of SVD at baseline was stronger associated with cognitive function after the 3-year follow-up than at baseline. WMLs progression was associated with more rapid decline of DSS tests compared to a group without progression.
  
  
  CONCLUSIONS
  SVD seen on MRI is a good marker for predicting future cognitive decline, and monitoring of treatment through the use of such markers is expected to maintain a good quality of life for elderly diabetic patients.
authors: Department of Diabetes and Endocrine Internal Medicine, Chubu Rosai Hospital, Nagoya, Japan.
authors: Rui
authors: R
authors: Imamine
authors: Takahiko
authors: T
authors: Kawamura
authors: Toshitaka
authors: T
authors: Umemura
authors: Hiroyuki
authors: H
authors: Umegaki
authors: Naoko
authors: N
authors: Kawano
authors: Megumi
authors: M
authors: Hotta
authors: Yu
authors: Y
authors: Kouchi
authors: Sawako
authors: S
authors: Hatsuda
authors: Atsuko
authors: A
authors: Watarai
authors: Akio
authors: A
authors: Kanai
authors: Eitaro
authors: E
authors: Nakashima
authors: Takahisa
authors: T
authors: Sano
authors: Toshimasa
authors: T
authors: Sakakibara
authors: Jiro
authors: J
authors: Nakamura
authors: Nigishi
authors: N
authors: Hotta
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D059345:Cerebral Small Vessel Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000473:pathology / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male