title: Kell hemolytic disease of the fetus. Combination treatment with plasmapheresis and intrauterine blood transfusion.
abstract: We report the case of a 36-year old pregnant woman with a Kell alloimmunization (anti-K1), probably secondary to a previous blood transfusion, and a severe hemolytic disease of the fetus. Once the first fetal blood transfusion by cordocentesis was performed, we started treatment with repeated plasmapheresis to maintain anti-K1 titer below 1:32. With this scheme we did not need to perform a second intrauterine fetal blood transfusion and only mild anemia was found in the newborn. Taking into account that the rate of serious complications with plasmapheresis is lower than that related with intrauterine blood transfusion, this could be an alternative approach to repeated transfusions.
authors: Department of Hematology, Hospital Universitario de Canarias, La Laguna, Spain. sunillakhwani@hotmail.com
authors: S
authors: S
authors: Lakhwani
authors: P
authors: P
authors: Machado
authors: P
authors: P
authors: Pecos
authors: M
authors: M
authors: Coloma
authors: S
authors: S
authors: Rebollo
authors: J M
authors: JM
authors: Raya
mesh_terms: D000328:Adult; D000740:Anemia / Q000276:immunology / Q000628:therapy*; D001805:Blood Transfusion, Intrauterine / Q000379:methods*; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D005315:Fetal Diseases / Q000097:blood / Q000276:immunology / Q000628:therapy*; D006402:Hematologic Diseases / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007626:Kell Blood-Group System / Q000276:immunology*; D010956:Plasmapheresis / Q000379:methods*; D011247:Pregnancy
chemical_list: D007626:Kell Blood-Group System