title: A theoretical study on the enhancement of functionally relevant electron transfers in biomimetic models of [FeFe]-hydrogenases.
abstract: Recent advances aimed at modeling the chemistry of the active site of [FeFe]-hydrogenases (the H-cluster, composed by a catalytic Fe(2)S(2) subcluster and an Fe(4)S(4) portion) have led to the synthesis of binuclear coordination compounds containing a noninnocent organophosphine ligand [2,3-bis(diphenylphosphino)maleic anhydride, bma] that is able to undergo monoelectron reduction, analogously to the tetranuclear Fe(4)S(4) subcluster portion of the H-cluster. However, such a synthetic model was shown to feature negligible electronic communication between the noninnocent ligand and the remaining portion of the cluster, at variance with the enzyme active site. Here, we report a theoretical investigation that shows why the electron transfer observed in the enzyme upon protonation of the catalytic Fe(2)S(2) subsite cannot take place in the bma-containing cluster. In addition, we show that targeted modifications of the bma ligand are sufficient to restore the electronic communication within the model, such that electron density can be more easily withdrawn from the noninnocent ligand, as a result of protonation of the iron centers. Similar results were also obtained with a ligand derived from cobaltocene. The relevance of our findings is discussed from the perspective of biomimetic reproduction of proton reduction to yield molecular hydrogen.
authors: Department of Biotechnology and Biosciences, Milan-Bicocca University, Piazza della Scienza 2, 20126, Milan, Italy. claudio.greco@unimib.it
authors: Claudio
authors: C
authors: Greco
authors: Luca
authors: L
authors: De Gioia
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D020134:Catalytic Domain; D004579:Electron Transport; D006864:Hydrogenase / Q000737:chemistry / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D008299:Maleic Anhydrides / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D011522:Protons; D013237:Stereoisomerism
chemical_list: D007506:Iron-Sulfur Proteins; D008024:Ligands; D008299:Maleic Anhydrides; D009942:Organometallic Compounds; D010720:Phosphines; D011522:Protons; C118830:iron hydrogenase; D006864:Hydrogenase; C044646:phosphine