title: The changes of pro-opiomelanocortin neurons in type 2 diabetes mellitus rats after ileal transposition: the role of POMC neurons.
abstract: BACKGROUND
  Ileal transposition (IT) can effectively resolve obesity and improve type 2 diabetes. IT is associated with increased glucagon-like peptide 1 secretion. The mechanisms mediating the effects of IT on obesity and diabetes remain undefined. Given the role of pro-opiomelanocortin neurons in energy balance, we sought to determine its potential role in these processes.
  
  
  METHODS
  Twenty non-obese diabetic Goto-Kakizaki rats underwent either IT or sham operation. Various measures including food intake, body weight, fasting plasma glucose, glucagon-like peptide 1 level, activated pro-opiomelanocortin neuron number, and pro-opiomelanocortin mRNA expression were evaluated.
  
  
  RESULTS
  The IT group demonstrated significantly improved plasma glucose homeostasis with increased glucagon-like peptide 1 secretion. The IT group ate less and demonstrated reduced body weight gain over time. These effects were also associated with increased central neuronal activity with increased pro-opiomelanocortin and derivative gene expression in the hypothalamus and increased protein expression in the pituitary gland.
  
  
  CONCLUSIONS
  More pro-opiomelanocortin neurons in the hypothalamus of diabetes rats were activated after ileal transposition. These data suggest a potential important role for pro-opiomelanocortin neurons in the resolution of diabetes after IT.
authors: Department of General Surgery, Qilu Hospital of Shandong University, 107#, Wenhua Xi Road, Jinan, 250012, Shandong, People's Republic of China.
authors: Weijie
authors: W
authors: Chen
authors: Zhibo
authors: Z
authors: Yan
authors: Shaozhuang
authors: S
authors: Liu
authors: Guangyong
authors: G
authors: Zhang
authors: Dong
authors: D
authors: Sun
authors: Sanyuan
authors: S
authors: Hu
mesh_terms: D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000601:surgery*; D015870:Gene Expression; D052216:Glucagon-Like Peptide 1 / Q000097:blood / Q000134:cerebrospinal fluid; D007082:Ileum / Q000601:surgery*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism; D011333:Pro-Opiomelanocortin / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D015854:Up-Regulation
chemical_list: D001786:Blood Glucose; D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin; D052216:Glucagon-Like Peptide 1