title: [Roles of ATP receptors in the regulation of various functions in spinal microglia].
abstract: It is shown that glial cells have a pivotal influence on the formation of neuronal network in central nerve system. Moreover, spinal microglia has some important roles in the development and progression of various neurological disorders. Therefore, it is possible that modulation of microglial activity may be sufficient to alleviate those harmful responses. ATP is one of signaling molecules in the spinal cord, and involved in regulation of several microglial functions through the binding of P2X and P2Y receptors. Thus, I focused on the ATP-mediated regulation mechanisms for the two important proteins, which are p38 MAP kinase and excitatory amino acid transporters (EAATs), in cultured spinal microglia. Mounting evidence indicates that p38 in spinal microglia has crucial roles in some neurological diseases. Furthermore, it is recently suggested that microglial EAATs might participate in the homeostasis of glutamate in synapses. This review summarizes our finding regarding the involvement of P2Y receptors and β-adrenergic receptors in the regulation of p38 phosphorylation, and the mechanism of P2X7 receptor-mediated downregulation of EAATs function.
authors: Department of Pharmacology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. mnori@hiroshima-u.ac.jp
authors: Norimitsu
authors: N
authors: Morioka
mesh_terms: D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D002478:Cells, Cultured; D015536:Down-Regulation; D050491:Glutamate Plasma Membrane Transport Proteins / Q000502:physiology; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D017628:Microglia / Q000502:physiology*; D009422:Nervous System Diseases / Q000209:etiology; D009638:Norepinephrine / Q000502:physiology; D010766:Phosphorylation; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D018048:Receptors, Purinergic P2 / Q000502:physiology*; D058469:Receptors, Purinergic P2X / Q000502:physiology; D058470:Receptors, Purinergic P2Y / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology*; D013569:Synapses / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000502:physiology
chemical_list: D050491:Glutamate Plasma Membrane Transport Proteins; D005971:Glutamates; D011943:Receptors, Adrenergic, beta; D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; D058470:Receptors, Purinergic P2Y; D000255:Adenosine Triphosphate; D048051:p38 Mitogen-Activated Protein Kinases; D009638:Norepinephrine