title: Highly regioselective intermolecular hydroacylations of enamides with salicylaldehydes.
abstract: Highly regioselective intermolecular hydroacylations of enamides under rhodium catalysis with monodentate phosphane ligands are reported for the first time. The presence of MeCN facilitates this novel C-C bond formation, and the electron-deficient phosphine P(p-F-Ph)(3) has proven most effective for the direct hydroacylation of 1-vinyl-2-pyrrolidinone. Accordingly, an atom-economic synthetic route to α-amido ketones from readily available substrates has been developed.
authors: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany.
authors: Hui-Jun
authors: HJ
authors: Zhang
authors: Carsten
authors: C
authors: Bolm