title: HDV-like self-cleaving ribozymes.
abstract: HDV ribozymes catalyze their own scission from the transcript during rolling circle replication of the hepatitis delta virus. In vitro selection of self-cleaving ribozymes from a human genomic library revealed an HDV-like ribozyme in the second intron of the human CPEB3 gene and recent results suggest that this RNA affects episodic memory performance. Bioinformatic searches based on the secondary structure of the HDV/CPEB3 fold yielded numerous functional ribozymes in a wide variety of organisms. Genomic mapping of these RNAs suggested several biological roles, one of which is the 5' processing of non-LTR retrotransposons. The family of HDV-like ribozymes thus continues to grow in numbers and biological importance.
authors: Department of Molecular Biology, University of California, Irvine, CA, USA.
authors: Chiu-Ho T
authors: CH
authors: Webb
authors: Andrej
authors: A
authors: Lupták
mesh_terms: D002874:Chromosome Mapping; D015894:Genome, Human; D003698:Hepatitis Delta Virus / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007438:Introns; D009690:Nucleic Acid Conformation; D016337:RNA, Catalytic / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D018626:Retroelements / Q000235:genetics; D014779:Virus Replication / Q000235:genetics
chemical_list: C513866:CPEB3 protein, human; D016337:RNA, Catalytic; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D018626:Retroelements