title: An association study of the genetic polymorphisms in 13 neural plasticity-related genes with semantic and episodic memories.
abstract: Semantic and episodic memories were two different attributes of long-term memory. In the past few years, plenty of physiological evidence has indicated that neural plasticity is involved in the formation of long-term memory. In the present study, we hypothesized that some functional variants of neural plasticity-related genes were related to episodic and semantic memories. To confirm this hypothesis, we examined the relationship of 13 plasticity-related genes with episodic and semantic memories. The results indicated that there was a statistically significant difference in semantic memory scores among the three genotype groups of T267C in 5-HT                         (                            6                         ) (χ                         (2) = 16.638, p = 0.0002). However, the functional variations in BDNF, COMT, DBH, DRD                         (                            2                         ), DRD                         (                            3                         ), DRD                         (                            4                         ), MAOA, TPH                         (                            2                         ), 5-HT                         (                            2A                         ), GRM                         (                            1                         ), and GRIN2B had no observable effects on the memories. Our preliminary results confirm the hypothesis that a small number of functional variants of the neural plasticity-related genes, such as T267C in 5-HT                         (                            6                         ), play important roles in human specific memory.
authors: Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health, Xi'an, 710069, China.
authors: Pingyuan
authors: P
authors: Gong
authors: Zijian
authors: Z
authors: Zheng
authors: Wanyu
authors: W
authors: Chi
authors: Xu
authors: X
authors: Lei
authors: Xiaodong
authors: X
authors: Wu
authors: Dongmei
authors: D
authors: Chen
authors: Kejin
authors: K
authors: Zhang
authors: Anyun
authors: A
authors: Zheng
authors: Xiaocai
authors: X
authors: Gao
authors: Fuchang
authors: F
authors: Zhang
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D057567:Memory, Long-Term; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000502:physiology; D009473:Neuronal Plasticity / Q000235:genetics*; D018377:Neurotransmitter Agents / Q000378:metabolism; D050479:Neurotransmitter Transport Proteins / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D011985:Receptors, Serotonin / Q000235:genetics* / Q000502:physiology; D021641:Recognition, Psychology; D012494:Sampling Studies; D014706:Verbal Learning; D055815:Young Adult
chemical_list: D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D050479:Neurotransmitter Transport Proteins; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin; C097216:serotonin 6 receptor