title: Non-normalized individual analysis of statistical parametric mapping for clinical fMRI.
abstract: BACKGROUND
  Pre-operative evaluation to localize function within the cerebral cortices is essential before brain surgery. Blood oxygenation level-dependent functional magnetic resonance imaging (fMRI) has been used for this purpose.
  
  
  OBJECTIVE
  To obtain clearer and more understandable functional images.
  
  
  METHODS
  Ten patients with brain tumors underwent fMRI including hand-gripping and word generation tasks. The statistical parametric mapping (SPM) approach was used for subsequent analysis to localize the motor or language functions. SPM includes image pre-processing, statistical computation, and significance testing. In order to demonstrate a spatial relationship between the lesions and a functioning area in the individual structural MR images, normalization to the Montreal Neurological Institute coordinates was intentionally not performed.
  
  
  RESULTS
  In seven cases out of 10, the patient's motor area was clearly visualized. Language areas were also demonstrated in seven cases.
  
  
  CONCLUSIONS
  We conclude that application of SPM (version 8) analysis to non-normalized individual data for the purpose of performing pre-operative fMRI is a useful method for investigation of functional localization.
authors: Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan. tnagatam.0222512.ns@gmail.com
authors: Takashi
authors: T
authors: Nagata
authors: Naohiro
authors: N
authors: Tsuyuguchi
authors: Takehiro
authors: T
authors: Uda
authors: Kenji
authors: K
authors: Ohata
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000473:pathology; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011597:Psychomotor Performance / Q000502:physiology; D014705:Verbal Behavior
chemical_list: D010100:Oxygen