title: Effects of perilla extract on productive performance, serum values and hepatic expression of lipid-related genes in Shaoxing ducks.
abstract: 1. The aim of this study was to identify the effect of perilla extract, a source of polyunsaturated fatty acids, on lipid metabolism and expression of lipid-related genes in livers of Shaoxing ducks. 2. Two hundred and forty 28-week-old laying ducks received a commercial diet with perilla extract added at 0 (control) or 200 mg/kg of feed. 3. Ducks fed on a diet with perilla extract had increased laying rates compared with control ducks. 4. Serum concentrations of triglycerides were reduced by perilla extract, while high-density lipoprotein cholesterol and total serum cholesterol increased. 5. The expression of genes involved in hepatic lipogenesis, sterol regulatory element-binding protein-1, acetyl CoA carboxylase, stearoyl CoA desaturase, fatty acid synthase, apolipoprotein B, and apolipoprotein very low density lipoprotein, were decreased in the perilla group. 6. The mRNA expression of peroxisome proliferators-activated receptor alpha and acyl-coenzyme A oxidase was enhanced following treatment with perilla extract, and a similar tendency was observed in the expression of liver fatty acid-binding protein. 7. The results show that a diet with 200 mg/kg perilla extract regulated fat metabolism of Shaoxing ducks by improving egg laying, altering serum lipid profiles, stimulating lipid catabolic gene expression and inhibiting lipogenic gene expression in the liver.
authors: College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, China.
authors: W M
authors: WM
authors: Liu
authors: J
authors: J
authors: Zhang
authors: L Z
authors: LZ
authors: Lu
authors: F X
authors: FX
authors: Shi
authors: D
authors: D
authors: Niu
authors: D L
authors: DL
authors: Wang
authors: B
authors: B
authors: Yu
authors: Z R
authors: ZR
authors: Tao
authors: J D
authors: JD
authors: Shen
authors: D Q
authors: DQ
authors: Wang
authors: Y
authors: Y
authors: Tian
mesh_terms: D042962:Acyl-CoA Oxidase / Q000378:metabolism; D000821:Animal Feed; D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004032:Diet / Q000662:veterinary; D004372:Ducks / Q000235:genetics* / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D031343:Perilla / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D012098:Reproduction / Q000187:drug effects; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D050556:Fatty Acid-Binding Proteins; D008074:Lipoproteins; D047493:PPAR alpha; D010936:Plant Extracts; D012333:RNA, Messenger; D014280:Triglycerides; D002784:Cholesterol; D042962:Acyl-CoA Oxidase