title: Temporal changes in the levels of perfluorinated compounds in California women's serum over the past 50 years.
abstract: Serum samples collected from California women at different time periods: 1960s (n = 40), 1980s (n = 30), and 2009 (n = 35) were examined for the presence of 12 perfluorinated compounds (PFCs) using an online SPE-HPLC-MS/MS method. At each time period, perfluorooctane sulfonate (PFOS) was present at the highest concentration, followed by perfluorooctanoic acid (PFOA, except in the 1960s). We found the highest levels of PFOS (median = 42.1 ng/mL) and perfluorohexane sulfonate (PFHxS, median = 1.56 ng/mL) in the 1960s samples, possibly reflecting widespread use of precursor PFCs. PFOS showed a statistically significant drop from the 1960s to the 1980s (28.8 ng/mL ) and to 2009 (9.0 ng/mL ), the latter being in agreement with national data. For PFOA, there was an approximately 10-fold increase in median concentrations from the 1960s (0.27 ng/mL) to the 1980s (2.71 ng/mL), and a slight drop in the 2009 samples (2.08 ng/mL). For longer chain perfluorocarboxylic acids (PFCAs), there was a continuous build-up in serum from the 1960s to 2009. To our knowledge, this is the first study to investigate temporal changes of PFCs over the past 50 years.
authors: Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, California 94710, United States. mwang@dtsc.ca.gov
authors: Miaomiao
authors: M
authors: Wang
authors: June-Soo
authors: JS
authors: Park
authors: Myrto
authors: M
authors: Petreas
mesh_terms: D000328:Adult; D002140:California; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D057230:Limit of Detection; D008137:Longitudinal Studies; D011247:Pregnancy; D011786:Quality Control; D053719:Tandem Mass Spectrometry / Q000379:methods; D013997:Time Factors
chemical_list: D004785:Environmental Pollutants; D005466:Fluorocarbons