title: Paraoxonase-1 192/55 polymorphisms and the risk of lung cancer in a Turkish population.
abstract: OBJECTIVE
  The purpose of the present study was to investigate the possible association of paraoxonase-1 (PON1) 192/55 polymorphisms with lung cancer (LC) risk in a Turkish population.
  
  
  METHODS
  A population-based, case-control study was carried out, including 223 patients with LC and 234 controls. The frequencies of PON1 192/55 genotypes were compared in patient and control groups using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
  
  
  RESULTS
  Distribution of PON1 192 R (+) genotype was found to be significantly higher in patients with LC compared to the controls (odds ratio: 1.497, 95% confidence interval: 1.034-2.166). This difference was especially noteworthy in patients with small cell carcinoma and squamous cell carcinoma.
  
  
  CONCLUSIONS
  This is the first case-control study on the association between PON1 polymorphisms and LC susceptibility in a Turkish population. Our results suggest that PON1 192 polymorphsim is associated with an increased risk of LC in the Turkish population and may be a useful genetic marker for small cell and squamous cell carcinoma.
authors: Department of Biochemistry, Pharmacy Faculty, Istanbul University, 34116, Istanbul, Turkey. aksoyp@istanbul.edu.tr
authors: Pinar
authors: P
authors: Aksoy-Sagirli
authors: Bedia
authors: B
authors: Cakmakoglu
authors: Turgay
authors: T
authors: Isbir
authors: Esra
authors: E
authors: Kaytan-Saglam
authors: Ahmet
authors: A
authors: Kizir
authors: Erkan
authors: E
authors: Topuz
authors: Hakan
authors: H
authors: Berkkan
mesh_terms: D043303:Aryldialkylphosphatase / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014421:Turkey
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human