title: A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: antibiotic activity of a first generation library.
abstract: An efficient synthetic route to 1,5-disubstituted 2-aminoimidazoles from readily available amino acids and aldehydes has been developed. A library of simple analogues was synthesized and several compounds were shown to exhibit notable antibiotic activity against a variety of bacterial strains including multi-drug resistant isolates.
authors: Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
authors: Tyler L
authors: TL
authors: Harris
authors: Roberta J
authors: RJ
authors: Worthington
authors: Christian
authors: C
authors: Melander
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007093:Imidazoles; C014973:2-aminoimidazole