title: Paraneoplastic cutaneous leukocytoclastic vasculitis disclosing multiple myeloma: a case report.
abstract: Cutaneous lesions are unusual during the course of multiple myeloma. In rare cases, multiple myeloma may be associated to skin involvement secondary to amyloidosis, cryoglobulinemia, and POEMS syndrome. Paraneoplastic skin involvement occurs preferentially during solid neoplasms. We report the case of an uncommon presentation of an IgA lambda multiple myeloma in a 58 year-old woman preceded by vascular purpura with cutaneous leukocytoclastic vasculitis (LV) and intense deposit of IgA and kappa light chains in the dermal vessels. Purpura resolved after specific treatment of multiple myeloma and diagnosis of paraneoplastic purpura was asserted. We propose a brief review of the literature about skin involvement during multiple myeloma. This case highlights the necessity to search for MM when we are facing a LV.
authors: Clinical Haematology, Hôpital Hôtel-Dieu, Nantes, France. pierrepeterlin@hotmail.fr
authors: Pierre
authors: P
authors: Peterlin
authors: Thierry
authors: T
authors: Ponge
authors: Nicolas
authors: N
authors: Blin
authors: Philippe
authors: P
authors: Moreau
authors: Mohamed
authors: M
authors: Hamidou
authors: Christian
authors: C
authors: Agard
mesh_terms: D003449:Cryoglobulinemia / Q000150:complications; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications; D007145:Immunoglobulin kappa-Chains / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007146:Immunoglobulin lambda-Chains / Q000097:blood / Q000378:metabolism / Q000652:urine; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000150:complications; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000150:complications* / Q000175:diagnosis / Q000276:immunology
chemical_list: D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains