title: A case of advanced hepatocellular carcinoma with portal vein tumor thrombus refractory to epirubicin that showed marked decrease in tumor markers after transcatheter arterial infusion with miriplatin.
abstract: Miriplatin, a cisplatin derivative with a high affinity for iodized ethyl esters of fatty acids from poppy seed oil, is a novel chemotherapeutic agent designed for use in the transarterial treatment of hepatocellular carcinoma (HCC). Here, we describe transcatheter arterial infusion (TAI) using miriplatin to treat a case of advanced HCC with portal vein tumor thrombus (PVTT) refractory to TAI with epirubicin. A 66-year-old man with advanced hepatitis C virus-related HCC with PVTT in the right lobe of the liver was treated with TAI with epirubicin suspended in iodized oil; however, tumor marker levels (alpha-fetoprotein and des-gamma-carboxy protein) did not decrease. Next, he was treated twice with TAI with miriplatin suspended in iodized oil. The tumor marker levels markedly decreased to a nearly normal range and the size of the main tumor was markedly reduced according to dynamic computed tomography. No serious adverse events occurred during the course of treatment with TAI and miriplatin. Therefore, we suggest that TAI with miriplatin is a safe and effective treatment option for advanced HCCs refractory to TAI with epirubicin.
authors: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan.
authors: Hiroki
authors: H
authors: Nishikawa
authors: Tadashi
authors: T
authors: Inuzuka
authors: Haruhiko
authors: H
authors: Takeda
authors: Jun
authors: J
authors: Nakajima
authors: Azusa
authors: A
authors: Sakamoto
authors: Sinichiro
authors: S
authors: Henmi
authors: Tetsurou
authors: T
authors: Ishikawa
authors: Sumio
authors: S
authors: Saito
authors: Ryuichi
authors: R
authors: Kita
authors: Toru
authors: T
authors: Kimura
authors: Yukio
authors: Y
authors: Osaki
authors: Yorimitsu
authors: Y
authors: Koshikawa