title: Wilms tumor gene 1 (WT1) is a prognostic marker in high-grade uterine sarcoma.
abstract: BACKGROUND
  Wilms tumor gene 1 (WT1) contributes to uterine sarcoma tumor biology. In this study, we aimed to clarify the prognostic value of WT1.
  
  
  METHODS
  A retrospective clinical and histopathological review of 71 women with high-grade uterine sarcoma (leiomyosarcoma [n = 24], undifferentiated sarcoma [n = 9]), and carcinosarcoma (n = 38) was performed. Patients were followed up for at least 12 months. Wilms tumor gene 1 expression was determined by immunohistochemistry. Data on recurrence (progression-free survival) and overall survival (OS) were available for all patients. Univariate and multivariate analyses of WT1 expression were carried out using Kaplan-Meier curves and Cox regression, respectively.
  
  
  RESULTS
  Forty-nine (69%) tumors were WT1 positive. Forty-seven (66%) patients died of the disease, with a median OS time of 22 months. Wilms tumor gene 1 was a predictor of survival in the univariate analysis: the hazard ratio of WT1 positivity was 2.44 (95% confidence interval, 1.34-4.71) for progression-free survival and 2.48 (95% confidence interval, 1.26-4.90) for OS. Multivariate analysis including stage, age, tumor size, and sarcoma subtype identified only stage and WT1 positivity as independent prognostic markers for survival.
  
  
  CONCLUSIONS
  The identification of WT1 as a prognostic marker confirms its role in high-grade uterine sarcoma and carcinosarcoma tumor biology.
authors: Laboratory of Experimental Gynecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium.
authors: An
authors: A
authors: Coosemans
authors: Ben
authors: B
authors: Van Calster
authors: Godelieve
authors: G
authors: Verbist
authors: Philippe
authors: P
authors: Moerman
authors: Ignace
authors: I
authors: Vergote
authors: Stefaan W
authors: SW
authors: Van Gool
authors: Frédéric
authors: F
authors: Amant
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics*; D002296:Carcinosarcoma / Q000235:genetics / Q000378:metabolism / Q000401:mortality; D005260:Female; D016162:Genes, Wilms Tumor; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000235:genetics / Q000378:metabolism / Q000401:mortality; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D012509:Sarcoma / Q000235:genetics* / Q000378:metabolism / Q000401:mortality; D016019:Survival Analysis; D014594:Uterine Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality; D025721:WT1 Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D025721:WT1 Proteins