title: Value of biomarker-based diagnostic test in differential diagnosis of hemorrhagic-ischemic stroke.
abstract: OBJECTIVE
  Stroke is an emergency which threatens life and the third leading cause of death in developed countries and the leading cause of long-term disability. By means of this study, it was aimed to evaluate the position of triage stroke panel in differential diagnosis of acute hemorrhagic stroke and ischemic stroke and sub-types of ischemic stroke.
  
  
  METHODS
  Patients with acute stroke admitted to Emergency Department were prospectively recruited between June 2008-January 2009. BNP, D-dimer, MMP-9, S-100b levels were asseyed. Statistical significance for intergroup differences was assessed by Pearson's chi2 for categorical variables and Mann-Whitney U test or Kruskal-Wallis test for continuous variables.
  
  
  CONCLUSIONS
  A total of 100 consecutive patients with a diagnosis of stroke were evaluated. Of these, 29 (29%) patients had brain hemorrhages on the computed tomography scan performed the Emergency Department, 71 (71%) patients had ischemic stroke. It was observed that the intercept obtained as a result of jointly evaluating BNP, D-dimer, MMP9 and S100b is more important in differential diagnosis (p < 0.005). We suggest that using a combination of plasma biomarkers may be usefull to ischemic or hemorrhagic stroke for differential diagnosis (Tab. 4, Ref. 22).
authors: Trakya University Faculty of Medicine, Emergency Department, Edirne, Turkey. cemkavalci@yahoo.com
authors: C
authors: C
authors: Kavalci
authors: H
authors: H
authors: Genchallac
authors: P
authors: P
authors: Durukan
authors: Y
authors: Y
authors: Cevik
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000175:diagnosis*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D009418:S100 Proteins / Q000097:blood; D020521:Stroke / Q000175:diagnosis / Q000209:etiology*
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D009418:S100 Proteins; C036309:fibrin fragment D; D020097:Natriuretic Peptide, Brain; D020780:Matrix Metalloproteinase 9