title: Synthesis, characterization, and antihyperglycemic activity of novel oxazolidine derivatives.
abstract: A number of compounds have been prepared in order to improve pharmacological roles of antihyperglycemic activity. In the present paper, a series of 3-benzyl-2-(4'-substituted phenyl)-4(5H)-(4″-nitrophenyl amino)-1,3-oxazolidines (6a-e) were tested against hyperglycemia. Their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded (SLM) models. Compounds 6a, b, c, d, and e displayed significant reductions in blood glucose in the streptozotocin and sucrose loaded rat models. The purity of the synthesized compounds was characterized by means of IR, (1)H-NMR, mass spectral and elemental analysis.
authors: Department of Pharmaceutical Chemistry, Srinivas College of Pharmacy, Valachil, Mangalore, 574 143 Karnataka, India. tpsphc@gmail.com
authors: Theivendren Panneer
authors: TP
authors: Selvam
authors: Palanirajan Vijayaraj
authors: PV
authors: Kumar
authors: Parthasarathi
authors: P
authors: Ramu
authors: Arumugam Siva
authors: AS
authors: Kumar
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013057:Spectrum Analysis; D013311:Streptozocin; D013395:Sucrose
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010080:Oxazoles; C064210:oxazolidine; D013395:Sucrose; D013311:Streptozocin