title: Antimicrobial activity of B-Lock against bacterial and Candida spp. causing catheter-related bloodstream infections.
abstract: The triple combination trimethoprim, EDTA, and ethanol (B-Lock), is an antimicrobial lock solution for use in indwelling intravascular catheters to prevent and treat catheter-associated infections. B-Lock demonstrated MICs of ≤0.05% (percentage of solution) against Candida spp. (n = 125) and 0.003% to 25% against bacterial strains (n = 175). B-Lock was also fungicidal against the majority of the Candida strains at 6% to 25%. B-Lock demonstrates potential value for the prevention and treatment of catheter-associated infections.
authors: Center for Medical Mycology, Department of Dermatology, University Hospitals Case Medical Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5028, USA. Mahmoud.Ghannoum@case.edu
authors: M A
authors: MA
authors: Ghannoum
authors: N
authors: N
authors: Isham
authors: M R
authors: MR
authors: Jacobs
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002175:Candida / Q000187:drug effects*; D055499:Catheter-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D002408:Catheters, Indwelling / Q000382:microbiology; D004338:Drug Combinations; D004492:Edetic Acid / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D014295:Trimethoprim / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D000431:Ethanol; D004492:Edetic Acid; D014295:Trimethoprim