title: Multifocal oral melanoacanthoma and melanotic macula in a patient after dental implant surgery.
abstract: BACKGROUND
  Oral melanoacanthoma (OMA) is an uncommon, reactive, pigmented mucocutaneous lesion. It is a rapidly growing, well-circumscribed, small, brown-to-black, solitary or multifocal macule that is characterized histopathologically by proliferation of keratinocytes and pigment-laden dendritic melanocytes.
  
  
  METHODS
  At the end of a one-month healing period after dental implant surgery, a 63-year-old white woman had pigmented lesions at different oral mucosal sites (hard palate, buccal mucosa and left maxillary tuberosity) that showed macrophages exhibiting iron and melanin in multiple areas of the lamina propria. The authors obtained biopsy specimens from all the lesions for histologic and immunohistochemical analyses and light-microscopy study.
  
  
  CONCLUSIONS
  Surgery could have been causal or incidental to the appearance of these lesions. Clinicians should be aware of this possible event and make a correct and pathologically confirmed differential diagnosis.
authors: Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Spain. pgalindo@ugr.es
authors: Pablo
authors: P
authors: Galindo-Moreno
authors: Miguel
authors: M
authors: Padial-Molina
authors: Mercedes
authors: M
authors: Gómez-Morales
authors: José
authors: J
authors: Aneiros-Fernández
authors: Francisco
authors: F
authors: Mesa
authors: Francisco
authors: F
authors: O'Valle
mesh_terms: D049309:Acanthoma / Q000175:diagnosis*; D003713:Dendritic Cells / Q000473:pathology; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D003937:Diagnosis, Differential; D005260:Female; D005887:Gingival Neoplasms / Q000175:diagnosis; D006801:Humans; D007501:Iron / Q000032:analysis; D008264:Macrophages / Q000473:pathology; D008543:Melanins / Q000032:analysis; D008544:Melanocytes / Q000473:pathology; D008548:Melanosis / Q000175:diagnosis*; D008875:Middle Aged; D009059:Mouth Diseases / Q000175:diagnosis*; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis*; D021362:Palate, Hard / Q000473:pathology; D011183:Postoperative Complications
chemical_list: D015921:Dental Implants; D008543:Melanins; D007501:Iron