title: The value of a family history of sudden death in patients with diagnostic type I Brugada ECG pattern.
abstract: OBJECTIVE
  We sought to investigate the value of a family history of sudden death (SD) in Brugada syndrome (BS).
  
  
  RESULTS
  Two hundred and eighty consecutive patients (mean age: 41 ± 18 years, 168 males) with diagnostic type I Brugada ECG pattern were included. Sudden death occurred in 69 (43%) of 157 families. One hundred and ten SDs were analysed. During follow-up VF (ventricular fibrillation) or SD-free survival rate was not different between patients with or without a family history of SD of a first-degree relative, between patients with or without a family history of multiple SD of a first-degree relative at any age and between patients with or without a family history of SD in first-degree relatives ≤35 years. One patient had family history of SD of two first-degree relative ≤35 years with arrhythmic event during follow-up. In univariate analysis male gender (P = 0.01), aborted SD (P < 0.001), syncope (P = 0.04), spontaneous type I ECG (P < 0.001), and inducibility during electrophysiological (EP) study (P < 0.001) were associated with worse prognosis. The absence of syncope, aborted SD, spontaneous type I ECG, and inducibility during EP study was associated with a significantly better prognosis (P < 0.001).
  
  
  CONCLUSIONS
  Family history of SD is not predictive for future arrhythmic events even if considering only SD in first-degree relatives or SD in first-degree relatives at a young age. The absence of syncope, aborted SD, spontaneous type I ECG, and inducibility during EP study is associated with a good five-year prognosis.
authors: Heart Rhythm Management Center, UZ Brussel-VUB, Laarbeeklaan 101, Brussels, Belgium. andreasarkozy@uzbrussel.be
authors: Andrea
authors: A
authors: Sarkozy
authors: Antonio
authors: A
authors: Sorgente
authors: Tim
authors: T
authors: Boussy
authors: Ruben
authors: R
authors: Casado
authors: Gaetano
authors: G
authors: Paparella
authors: Lucio
authors: L
authors: Capulzini
authors: Gian-Battista
authors: GB
authors: Chierchia
authors: Yoshinao
authors: Y
authors: Yazaki
authors: Carlo
authors: C
authors: De Asmundis
authors: Danny
authors: D
authors: Coomans
authors: Josep
authors: J
authors: Brugada
authors: Pedro
authors: P
authors: Brugada
mesh_terms: D000328:Adult; D053840:Brugada Syndrome / Q000235:genetics* / Q000401:mortality; D016757:Death, Sudden, Cardiac / Q000209:etiology* / Q000517:prevention & control; D004562:Electrocardiography; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013575:Syncope / Q000235:genetics / Q000401:mortality; D055815:Young Adult