title: Platelet and soluble glycoprotein VI - novel applications in diagnosis and therapy.
abstract: One of the key receptors involved in the prothrombotic stage of an acute coronary syndrome (ACS) is platelet glycoprotein VI (GPVI). This constitutively expressed collagen receptor is platelet-specific and has shown to be a useful biomarker tool for the early detection of atheroslerotic diseases such as ACS and ischemic stroke. In a multimarker panel of several biomarkers, platelet GPVI may contribute to risk stratification and prediction of clinical outcome in patients with symptomatic atherosclerotic diseases. Moreover, the soluble receptor of GPVI may also be an interesting and prospective target for molecular imaging to identify sites of vulnerable plaques as the results of preclinical studies suggest. Apart from the diagnostic use of platelet as well as soluble, plasmatic GPVI, therapeutical implications may be the blockade of collagen binding sides of GPVI, as platelet GPVI is not able to bind to collagen where the binding sides were already saturated with soluble GPVI. This therapeutic aspect could serve as a promising strategy for antithrombotic and antiatherosclerotic therapy in future.
authors: Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard-Karls-Universität Tübingen, Germany.
authors: Boris
authors: B
authors: Bigalke
authors: Margitta
authors: M
authors: Elvers
authors: Tanja
authors: T
authors: Schönberger
authors: Meinrad
authors: M
authors: Gawaz
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D018955:CD36 Antigens / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000097:blood / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D058426:Neointima / Q000175:diagnosis; D058226:Plaque, Atherosclerotic / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism; D015539:Platelet Activation / Q000187:drug effects; D012995:Solubility; D013927:Thrombosis / Q000188:drug therapy / Q000378:metabolism
chemical_list: D015415:Biomarkers; D018955:CD36 Antigens; D005343:Fibrinolytic Agents