title: Copper/DIPEA-catalyzed, aldehyde-induced tandem decarboxylation-coupling of natural α-amino acids and phosphites or secondary phosphine oxides.
abstract: A copper/DIPEA-catalyzed, aldehyde-induced intermolecular decarboxylative coupling reaction of natural α-amino acids and phosphites or secondary phosphine oxides was developed. In this process, a series of potentially useful ligands for organic synthesis and biologically important unnatural amino acid derivatives (tertiary amino phosphorus compounds) were obtained.
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Medicine, and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, P. R. China.
authors: Dongxu
authors: D
authors: Yang
authors: Depeng
authors: D
authors: Zhao
authors: Lijuan
authors: L
authors: Mao
authors: Linqing
authors: L
authors: Wang
authors: Rui
authors: R
authors: Wang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D005021:Ethylamines / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D017905:Phosphites / Q000737:chemistry*; D017553:Phosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000596:Amino Acids; D005021:Ethylamines; D010720:Phosphines; D017905:Phosphites; D017553:Phosphorus Compounds; C027070:N,N-diisopropylethylamine; D003300:Copper