title: Reversible post-pregabalin peripheral edema in a spinal cord injury patient.
abstract: METHODS
  Case report.
  
  
  OBJECTIVE
  To report a case of paraplegia with limb edema caused by pregabalin.
  
  
  METHODS
  Turkish Armed Forces Rehabilitation Center, Ankara, Turkey.
  
  
  METHODS
  A 40-year-old male patient with T11 paraplegia had the complaint of swelling in both the lower limbs. He had been given pregabalin because of the neuropathic pain in both the lower limbs. At 10 months, the patient has experienced edema in lower limbs. There was severe edema in both legs, ankles and feet, more evident on the left. Venous Doppler ultrasound was normal on both sides. Blood tests for possible etiologies were normal. No other etiology could be found. The edema was considered to be caused by pregabalin and the medicine was ceased gradually. The edema resolved completely in 2 weeks.
  
  
  CONCLUSIONS
  Pregabalin, which is one of medications used for neuropathic pain, might cause limb edema, that is, a condition needs differential diagnosis. This is particularly important for patients with spinal cord injuries (SCIs). Such adverse effect of pregabalin should be kept in mind as an etiology of limb edema in SCI management.
authors: Department of Physical Medicine and Rehabilitation, Gülhane Military Medical Academy, Turkish Armed Forces Rehabilitation Center, Ankara, Turkey. druguzelkucuk@yahoo.com
authors: U
authors: U
authors: Guzelkucuk
authors: I
authors: I
authors: Duman
authors: B
authors: B
authors: Yılmaz
authors: A K
authors: AK
authors: Tan
mesh_terms: D000328:Adult; D000700:Analgesics / Q000009:adverse effects*; D004487:Edema / Q000139:chemically induced*; D006801:Humans; D035002:Lower Extremity / Q000473:pathology*; D008297:Male; D009437:Neuralgia / Q000209:etiology / Q000628:therapy; D010264:Paraplegia / Q000209:etiology; D000069583:Pregabalin; D013119:Spinal Cord Injuries / Q000150:complications*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000700:Analgesics; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid