title: Automatic segmentation of pulmonary blood vessels and nodules based on local intensity structure analysis and surface propagation in 3D chest CT images.
abstract: OBJECTIVE
  Pulmonary nodules may indicate the early stage of lung cancer, and the progress of lung cancer causes associated changes in the shape and number of pulmonary blood vessels. The automatic segmentation of pulmonary nodules and blood vessels is desirable for chest computer-aided diagnosis (CAD) systems. Since pulmonary nodules and blood vessels are often attached to each other, conventional nodule detection methods usually produce many false positives (FPs) in the blood vessel regions, and blood vessel segmentation methods may incorrectly segment the nodules that are attached to the blood vessels. A method to simultaneously and separately segment the pulmonary nodules and blood vessels was developed and tested.
  
  
  METHODS
  A line structure enhancement (LSE) filter and a blob-like structure enhancement (BSE) filter were used to augment initial selection of vessel regions and nodule candidates, respectively. A front surface propagation (FSP) procedure was employed for precise segmentation of blood vessels and nodules. By employing a speed function that becomes fast at the initial vessel regions and slow at the nodule candidates to propagate the front surface, the front surface can be propagated to cover the blood vessel region with suppressed nodules. Hence, the resultant region covered by the front surface indicates pulmonary blood vessels. The lung nodule regions were finally obtained by removing the nodule candidates that are covered by the front surface.
  
  
  RESULTS
  A test data set was assembled including 20 standard-dose chest CT images obtained from a local database and 20 low-dose chest CT images obtained from lung image database consortium (LIDC). The average extraction rate of the pulmonary blood vessels was about 93%. The average TP rate of nodule detection was 95% with 9.8 FPs/case in standard-dose CT image, and 91.5% with 10.5 FPs/case in low-dose CT image, respectively.
  
  
  CONCLUSIONS
  Pulmonary blood vessels and nodules segmentation method based on local intensity structure analysis and front surface propagation were developed. The method was shown to be feasible for nodule detection and vessel extraction in chest CAD.
authors: Graduate School of Information Science, Nagoya University, Nagoya, Japan. bchen@mori.m.is.nagoya-u.ac.jp
authors: Bin
authors: B
authors: Chen
authors: Takayuki
authors: T
authors: Kitasaka
authors: Hirotoshi
authors: H
authors: Honma
authors: Hirotsugu
authors: H
authors: Takabatake
authors: Masaki
authors: M
authors: Mori
authors: Hiroshi
authors: H
authors: Natori
authors: Kensaku
authors: K
authors: Mori
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000077192:Adenocarcinoma of Lung; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D006801:Humans; D021621:Imaging, Three-Dimensional; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D011856:Radiographic Image Enhancement / Q000379:methods; D012984:Software; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*