title: [Antitumor effects of sulindac in ovarian cell cultures].
abstract: OBJECTIVE
  The purpose of our study was to assess susceptibility of cells of various ovarian cell lines on different nonsteroidal anti-inflammatory drugs (NSAIDs).
  
  
  METHODS
  Cytotoxic effect of NSAIDs was tested using MTT colorimetric assay.
  
  
  RESULTS
  Amongst 6 NSAIDs tested: sulindac, sulindac sulfide, sulindac sulfone, acetylsalicylic acid, nimesulide, and rofecoxib, viability of ovarian carcinoma cells was compromised most strongly by sulindac and sulindac sulfide and concerned all the cell lines tested: SKOV-3, MDAH 2774, OVCA-1, and OVP-10. Sulindac sulfone and rofecoxib also displayed some cytotoxic effect during prolonged 72-hour incubation. Other NSAIDs tested: nimesulide and acetylsalicylic acid were devoid of cytotoxic effect on ovarian cancer cells.
  
  
  CONCLUSIONS
  Our results are encourage enough to conduct clinical trials that could allow to draw conclusions regarding potential application of sulindac in the adjuvant treatment of a standard chemotherapy of ovarian cancer.
authors: Zakład Immunologii, Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie, Warszawa, Polska.
authors: Anna
authors: A
authors: Jakubowska-Mućka
authors: Jacek
authors: J
authors: Sieńko
authors: Tomasz
authors: T
authors: Switaj
authors: Jakub
authors: J
authors: Gołab
authors: Witold
authors: W
authors: Lasek
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003124:Colorimetry; D005260:Female; D006801:Humans; D007783:Lactones / Q000494:pharmacology; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D013449:Sulfonamides / Q000494:pharmacology; D013450:Sulfones / Q000494:pharmacology; D013467:Sulindac / Q000031:analogs & derivatives* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D007783:Lactones; D013449:Sulfonamides; D013450:Sulfones; C116926:rofecoxib; D013467:Sulindac; C025462:sulindac sulfide; C025463:sulindac sulfone; D001241:Aspirin; C012655:nimesulide