title: Organocatalyzed enantioselective fluorocyclizations.
abstract: Enantioenriched fluorinated heterocycles can be prepared through fluorocyclizations of prochiral indoles (see scheme; Ts=tosyl, Bn=benzyl, Boc=tert-butoxycarbonyl). More than twenty examples for this cascade fluorination-cyclization, which is catalyzed by cinchona alkaloids and employs N-fluorobenzenesulfonimide as the electrophilic fluorine source have been explored, and an unprecedented catalytic asymmetric difluorocyclization has also been identified.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, UK.
authors.forename: Oscar
authors.initials: O
authors.lastname: Lozano
authors.forename: George
authors.initials: G
authors.lastname: Blessley
authors.forename: Teresa
authors.initials: T
authors.lastname: Martinez del Campo
authors.forename: Amber L
authors.initials: AL
authors.lastname: Thompson
authors.forename: Guy T
authors.initials: GT
authors.lastname: Giuffredi
authors.forename: Michela
authors.initials: M
authors.lastname: Bettati
authors.forename: Matthew
authors.initials: M
authors.lastname: Walker
authors.forename: Richard
authors.initials: R
authors.lastname: Borman
authors.forename: Véronique
authors.initials: V
authors.lastname: Gouverneur