title: Clara cell protein 10 polymorphism is not associated with severe respiratory syncytial virus infection.
abstract: OBJECTIVE
  To investigate a possible correlation between severe respiratory syncytial virus (RSV) infection and single-nucleotide polymorphism (SNP) in the Clara cell protein 10 (CC10) gene (A38G).
  
  
  METHODS
  Children hospitalized with severe RSV lower respiratory tract (LRTI) infection at Karolinska University Hospital, Stockholm, during three subsequent RSV seasons were selected and genotyped. Age-matched controls were used. The two groups were compared regarding SNP in the CC10 gene (A38G) and regarding later development of wheezing.
  
  
  RESULTS
  No correlation was found between the genotype CC10 +38AA and severe RSV infection or wheezing during follow-up. Wheezing (p = 0.022), frequent wheezing (≥3 episodes) (p =0.042) as well as ever wheezing (p = 0.0022) occurred significantly more often after discharge in children hospitalized for RSV compared with the control group.
  
  
  CONCLUSIONS
  Single-nucleotide polymorphism in the CC10 gene (A38G) does not seem to be involved in the severity of RSV infection or wheezing. In agreement with other studies, we found that children with severe RSV are at increased risk of future wheezing. The latter finding implies that the studied population represented children with severe LRTI, which supports that a correlation between the genotype CC10 +38AA and severe RSV is less likely.
authors.affiliation: Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. henrik.overodder@karolinska.se
authors.forename: Henrik
authors.initials: H
authors.lastname: Overödder
authors.forename: Lars
authors.initials: L
authors.lastname: Navér
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012135:Respiratory Sounds / Q000235:genetics; D018357:Respiratory Syncytial Virus Infections / Q000235:genetics*; D012720:Severity of Illness Index; D013548:Sweden; D014598:Uteroglobin / Q000235:genetics*
chemical_list: C556389:SCGB1A1 protein, human; D014598:Uteroglobin