title: Sustained release of 5-fluorouracil by incorporation into sodium carboxymethylcellulose sub-micron fibers.
abstract: This work introduces a novel route to the sodium carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug, 5-fluorouracil (5-Fu). The results show that 5-Fu is successfully incorporated into the biocompatible polymer, sodium carboxymethylcellulose (NaCMC)-based fibers with good stability, desired drug loading content and 100% entrapment efficiency. Furthermore, the drug release rate of the as-prepared drug-loaded fibers could be well controlled. The drug release behavior of the 5-Fu-loaded NaCMC fibers shows a diffusion mechanism, obeying Ritger-Peppas kinetics model. The drug release behavior of the as-prepared products demonstrates their promising application in drug delivery system.
authors.affiliation: School of Pharmaceutical Science and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, Jinan, Shandong Province 250012, PR China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Cai
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Luan
authors.forename: Qian
authors.initials: Q
authors.lastname: Dong
authors.forename: Wei
authors.initials: W
authors.lastname: Shao
authors.forename: Zhonghao
authors.initials: Z
authors.lastname: Li
authors.forename: Zhongxi
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004355:Drug Stability; D005472:Fluorouracil / Q000008:administration & dosage*; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008962:Models, Theoretical
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D002266:Carboxymethylcellulose Sodium; D005472:Fluorouracil