title: Cytomegalovirus endotheliitis after fluocinolone acetonide (Retisert) implant in a patient with Behçet uveitis.
abstract: OBJECTIVE
  To report a case of cytomegalovirus (CMV) endotheliitis after insertion of an intravitreal fluocinolone acetonide (Retisert) implant.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  Retrospective chart review.
  
  
  RESULTS
  A 40-year-old man received a Retisert implant in the left eye for recurrent Behçet uveitis. Although inflammation became quiescent within a month, corneal edema developed 4 months after insertion. Polymerase chain reaction analysis for aqueous humor detected 3.9 × 10(4) copies/mL of CMV DNA. After treatment with oral valganciclovir, CMV DNA nearly disappeared but visual outcome was poor due to corneal decompensation resulting from severe endothelial cell loss.
  
  
  CONCLUSIONS
  After Retisert implant, clinicians should be attentive to the potential risk of CMV endotheliitis.
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Un Chul
authors.initials: UC
authors.lastname: Park
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Hyeong Gon
authors.initials: HG
authors.lastname: Yu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000998:Antiviral Agents / Q000008:administration & dosage; D001528:Behcet Syndrome / Q000150:complications*; D015715:Corneal Edema / Q000150:complications / Q000188:drug therapy / Q000821:virology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D004343:Drug Implants / Q000009:adverse effects; D004728:Endothelium, Corneal / Q000821:virology*; D005446:Fluocinolone Acetonide / Q000008:administration & dosage*; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D008297:Male; D014605:Uveitis / Q000188:drug therapy* / Q000209:etiology; D000077562:Valganciclovir; D014786:Vision Disorders / Q000209:etiology
chemical_list: D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D004343:Drug Implants; D005446:Fluocinolone Acetonide; D000077562:Valganciclovir; D015774:Ganciclovir