title: Synthesis, characterization and DNA binding and cleavage properties of ruthenium(II) complexes with various polypyridyls.
abstract: Polypyridyl chlororuthenium(II) complexes have been synthesized and characterized. The binding mode of the complexes to DNA has been evaluated from the combined results of electronic absorption spectroscopy and viscosity measurement study. The results suggest that complexes 1, 2 and 3 bind to DNA via classical intercalation, electrostatic interaction and partial intercalation mode, respectively. Complex 2 shows less affinity for DNA. Cleavage of pUC19 DNA by complexes has been checked using gel electrophoresis. The data disclose that complex 1 has the highest cleaving ability.
authors.affiliation: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India. jeenenpatel@yahoo.co.in
authors.forename: Mohan N
authors.initials: MN
authors.lastname: Patel
authors.forename: Pradhuman A
authors.initials: PA
authors.lastname: Parmar
authors.forename: Deepen S
authors.initials: DS
authors.lastname: Gandhi
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004587:Electrophoresis, Agar Gel; D008297:Male; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D011725:Pyridines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013054:Spectrophotometry, Atomic; D013094:Spermatozoa / Q000737:chemistry; D055672:Static Electricity
chemical_list: D009942:Organometallic Compounds; D011725:Pyridines; D012428:Ruthenium; D004247:DNA