title: IGF-1 levels are significantly correlated with patient-reported measures of sexual function.
abstract: Growth hormone (GH) supplementation may help to preserve erectile function. We assessed whether serum insulin-like growth factor 1 (IGF-1) levels, a surrogate for GH levels, correlate with sexual function scores in 65 men who completed the Sexual Health Inventory for Men (SHIM) and Expanded Prostate Cancer Index Composite (EPIC) questionnaires, and had serum IGF-1 and testosterone levels determined. Median±s.d. IGF-1 level, SHIM and EPIC scores were 235.0±86.4, 19.5±8.7 and 56.4±28.3 mg ml(-1), respectively. IGF-1 levels and total SHIM score correlate significantly (r=0.31, P=0.02), as do IGF-1 levels and all individual SHIM question scores, and IGF-1 levels and the sexual domain of the EPIC questionnaire (r=0.30, P=0.02). No correlation was observed between IGF-1 levels and Gleason score, IGF-1 and testosterone level or SHIM score and testosterone level. These data support a potential role for the GH axis in erectile function.
authors.affiliation: Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: A W
authors.initials: AW
authors.lastname: Pastuszak
authors.forename: J S
authors.initials: JS
authors.lastname: Liu
authors.forename: A
authors.initials: A
authors.lastname: Vij
authors.forename: O
authors.initials: O
authors.lastname: Mohamed
authors.forename: K
authors.initials: K
authors.lastname: Sathyamoorthy
authors.forename: L I
authors.initials: LI
authors.lastname: Lipshultz
authors.forename: M
authors.initials: M
authors.lastname: Khera
mesh_terms: D000368:Aged; D015897:Comorbidity; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012735:Sexual Dysfunction, Physiological / Q000097:blood* / Q000453:epidemiology; D013739:Testosterone / Q000097:blood; D014481:United States / Q000453:epidemiology
chemical_list: D013739:Testosterone; D007334:Insulin-Like Growth Factor I