title: [Body mass index influence on aortic valve stenosis].
abstract: OBJECTIVE
  The 12 months' observation of body mass index (BMI) influence on natural course of aortic valve stenosis (AVS).
  
  
  METHODS
  60 AVS patients who did not agree for operational treatment were divided into group A (n = 15) with BMI 20-25, group B (n = 27) with BMI 25,01-30 and group C BMI > 30.
  
  
  METHODS
  Plasma Lp(a), total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha) as well as titers of immunoglobulin (Ig) class G, A, M against chlamydia pneumoniae were measured every 12 months. Echo-cardiographic evaluation of aortic valve was also done every 12 months.
  
  
  RESULTS
  Means serum CRP at 12 month was the highest in group C. No differences in mean serum TNF-alpha and IL-6 levels as well as in Ig titers between groups A, B, C were found. At 12 month of observation HDL/total cholesterol ratio as well as HDL/LDL-cholesterol ratio were the lowest in group B. Left atrium diameter and right ventricle diameter were bigger in groups B and C compared to group A at the visit I and after 12 months of observation. Systolic intraventricular septum (IVS syst) thickness was the highest in group C at visit I. Diastolic left ventricle posterior wall thickness (LVPW) was the highest in group C during 12 months of observation.
  
  
  CONCLUSIONS
  The increase in fat tissue mass may lead to increase in inflammatory process and cardiac muscle remodeling in AVS patients.
authors.affiliation: II Klinika Kardiologii Collegium Medicum, Uniwersytetu Jagiellońskiego. grasshoppers@interia.eu
authors.forename: Jolanta
authors.initials: J
authors.lastname: Swierszcz
authors.forename: Jacek S
authors.initials: JS
authors.lastname: Dubiel
authors.forename: Józef
authors.initials: J
authors.lastname: Krzysiek
authors.forename: Krystyna
authors.initials: K
authors.lastname: Sztefko
authors.forename: Danuta
authors.initials: D
authors.lastname: Galicka-Latała
authors.forename: Roman
authors.initials: R
authors.lastname: Pfitzner
authors.forename: Piotr
authors.initials: P
authors.lastname: Podolec
authors.forename: Jan
authors.initials: J
authors.lastname: Wodniecki
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000000981:diagnostic imaging*; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000145:classification; D014463:Ultrasonography
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol