title: The -1082A/G polymorphism in the Interleukin-10 gene and the risk of rheumatoid arthritis: a meta-analysis.
abstract: A large number of studies have shown that the -1082A/G polymorphism (rs1800896) in the Interleukin-10 gene (IL-10) is implicated in the susceptibility to rheumatoid arthritis (RA). However, the results are inconsistent and inconclusive. The aim of this study is to analyze the association between the -1082A/G polymorphism in the IL-10 gene and the RA risk by meta-analysis. A total of 1480 cases and 1413 controls in 10 case-control studies were included in this meta-analysis. The results indicated that the G allele carriers (GG+GA) had a 25% decreased risk of RA, when compared with the homozygote AA (odds ratio (OR)=0.75, 95% confidence interval (CI): 0.59-0.93). In the analysis in Europeans, significant decreased risks were associated with the G allele carriers (OR=0.73 and 95% CI: 0.57-0.93 for GG+GA vs. AA). The results from this meta-analysis provide evidence for the association between the IL-10 -1082A/G polymorphism and the risk of RA. To further evaluate gene×gene and gene×environment interactions between the polymorphisms in the IL-10 gene and RA risk, more studies with large groups of patients are required.
authors.affiliation: Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou Medical College, Wenzhou, Zhejiang 325035, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Kejian
authors.initials: K
authors.lastname: Xie
authors.forename: Chaowei
authors.initials: C
authors.lastname: Wen
authors.forename: Ruiping
authors.initials: R
authors.lastname: Cheng
authors.forename: Cong
authors.initials: C
authors.lastname: Chen
authors.forename: Jianxi
authors.initials: J
authors.lastname: Lu
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D016753:Interleukin-10