title: A GAP in our knowledge of vascular signaling in acute kidney injury.
abstract: Injury resulting from ischemia-reperfusion injury is a multifactorial process involving compromised function in both the tubular and the vascular compartments. Multiple vasoactive compounds have been implicated in the profound vasoconstriction that occurs in response to ischemia-reperfusion injury, and many of these factors signal through common G protein-coupled receptors. The report by Siedlecki et al. highlights the important roles of RGS4, a GTPase-accelerating protein (GAP), in the regulation of vascular tone in the setting of acute kidney injury.
authors.affiliation: Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA. dpbasile@iupui.edu
authors.forename: David P
authors.initials: DP
authors.lastname: Basile
mesh_terms: D058186:Acute Kidney Injury / Q000517:prevention & control*; D000818:Animals; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D020710:RGS Proteins / Q000378:metabolism*; D012079:Renal Circulation; D015427:Reperfusion Injury / Q000201:enzymology*; D014661:Vasoconstriction
chemical_list: D020710:RGS Proteins; C098799:RGS4 protein; D043802:GTP-Binding Protein alpha Subunits, Gq-G11