title: [Correlation between serum growth differentiation factor-15 and TIMI risk scores in patients with unstable angina pectoris].
abstract: OBJECTIVE
  To explore the correlation between serum levels of growth differentiation factor-15 (GDF-15) and Thrombolysis in Myocardial Infarction (TIMI) risk scores in patients with unstable angina pectoris (UA).
  
  
  METHODS
  The serum levels of GDF-15 in 97 patients with UA and 30 healthy volunteers were measured using enzyme-linked immunosorbent assay (ELISA) and compared between 3 patient groups with different TIMI scores to analyze relationship between serum GDF-15 levels and TIMI risk scores.
  
  
  RESULTS
  The serum levels of GDF-15 in UA patients were significantly higher than those in the healthy volunteers (P<0.01). GDF-15 levels also differed significantly between patients with different TIMI scores (P<0.01), and showed a significant positive correlation to TIMI risk scores.
  
  
  CONCLUSIONS
  Serum levels of GDF-15 can be used as an index for evaluating the severity of UA.
authors.affiliation: Department of Cardiology, Sanya Peoples Hospital, Sanya 572000, China.
authors.forename: Ming-yao
authors.initials: MY
authors.lastname: Deng
authors.forename: Guo-ping
authors.initials: GP
authors.lastname: Wu
authors.forename: Xu-xia
authors.initials: XX
authors.lastname: Feng
authors.forename: Jiang-bin
authors.initials: JB
authors.lastname: Luo
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000097:blood* / Q000188:drug therapy; D005260:Female; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012720:Severity of Illness Index; D015912:Thrombolytic Therapy / Q000009:adverse effects*
chemical_list: D055436:Growth Differentiation Factor 15