title: Disparity of innate immunity-related gene effects on asthma and allergy on Karelia.
abstract: BACKGROUND
  We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children.
  
  
  METHODS
  Karelian children (412 Finnish and 446 Russian) were recruited and assessed for a range of allergic conditions, with 24 single-nucleotide polymorphisms genotyped in 15 genes.
  
  
  RESULTS
  The genotype-phenotype relationships differed in Finnish and Russian Karelian children. The interaction between polymorphisms and the variable representing 'Western' and 'Eastern' environments/ lifestyles was significant for IL10-1082 (p = 0.0083) on current rhinitis, IL12b 6408 on current conjunctivitis (p = 0.016) and atopy (p = 0.034), IL8 781 on atopic eczema (p = 0.0096), CD14 -550 on current rhinitis (p = 0.022), IFNgR1 -56 on atopic eczema(p = 0.038), and STAT6 2964 on current itchy rash (p = 0.037) and total serum IgE (p = 0.042). In addition, the G allele of IL13 130 was associated with a lower level of total serum IgE in Finnish (p = 0.003) and Russian (p = 0.01) children and overall (pooling the two populations together, p = 0.00006). After adjusting for multiple tests, the association between IL13 130 and IgE and the interactive effects of IL10-1082 on current rhinitis and IL8 781 on atopic eczema were significant by controlling a false-positive rate of 0.05 and 0.10, respectively.
  
  
  CONCLUSIONS
  Living in an Eastern vs. Western environment was associated with a different genetic profile associated with asthma and allergy in the Karelian populations.
authors.affiliation: School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia. Bradz@ichr.uwa.edu.au
authors.forename: Guicheng
authors.initials: G
authors.lastname: Zhang
authors.forename: Pierre
authors.initials: P
authors.lastname: Candelaria
authors.forename: J Mika
authors.initials: JM
authors.lastname: Mäkelä
authors.forename: Siew-Kim
authors.initials: SK
authors.lastname: Khoo
authors.forename: M Catherine
authors.initials: MC
authors.lastname: Hayden
authors.forename: Leena
authors.initials: L
authors.lastname: von Hertzen
authors.forename: Tiina
authors.initials: T
authors.lastname: Laatikainen
authors.forename: Erkki
authors.initials: E
authors.lastname: Vartiainen
authors.forename: Jack
authors.initials: J
authors.lastname: Goldblatt
authors.forename: Tari
authors.initials: T
authors.lastname: Haahtela
authors.forename: N Peter
authors.initials: NP
authors.lastname: LeSouëf
mesh_terms: D001249:Asthma / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D002648:Child; D005260:Female; D005387:Finland / Q000453:epidemiology; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D012426:Russia / Q000453:epidemiology