title: Preparation and release characteristic of quercetin loaded poly(lactic acid) ultrafine fibers.
abstract: In this study, poly(lactic acid) (PLA) ultrafine fibers have been prepared by electrospinning method using mix-solvent. The results showed that the variation of solvent ratio (N,N-dimethylformamide (DMF)/Dichloromethane (DCM)) could change the surface morphology of PLA nanofibers. By adjusting the solvent ratio, the quercetin release rate from the fiber membranes could be controlled. Furthermore, by adjusting the PLA concentration, the nanofibers without beads could be obtained. After addition of quercetin to polymer solution, the spindle-shaped beads on the fiber disappeared, but surface morphology of the fiber changed little with increase in quercetin dosage, and the release rate of quercetin increased with increase of quercetin dosage.
authors.affiliation: State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Jinrong
authors.initials: J
authors.lastname: Peng
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Qian
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Shaozhi
authors.initials: S
authors.lastname: Fu
authors.forename: Gang
authors.initials: G
authors.lastname: Guo
authors.forename: Feng
authors.initials: F
authors.lastname: Luo
authors.forename: Ruixia
authors.initials: R
authors.lastname: Li
authors.forename: Dacheng
authors.initials: D
authors.lastname: Wu
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D004058:Diffusion; D019344:Lactic Acid / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D011794:Quercetin / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000975:Antioxidants; D046911:Macromolecular Substances; D053769:Nanocapsules; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D011794:Quercetin