title: Regio- and stereoselective synthesis of multisubstituted olefins and conjugate dienes by using α-oxo ketene dithioacetals as the building blocks.
abstract: An efficient palladium(0)-catalyzed, Cu(I)-mediated synthetic route to trisubstituted olefins and conjugate dienes has been developed via oxo directing Liebeskind-Srogl cross-coupling reactions of gem-dihaloolefin-type α-oxo ketene dithioacetals with aryl and alkenylboronic acids. The synthetic protocol has demonstrated rare examples of transition-metal-promoted transformations of ketene dithioacetals, providing a novel route to highly functionalized conjugate dienes.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 457 Zhongshan Road, Dalian, Liaoning 116023, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Jin
authors.forename: Wangming
authors.initials: W
authors.lastname: Du
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Haifeng
authors.initials: H
authors.lastname: Yu
authors.forename: Jiping
authors.initials: J
authors.lastname: Chen
authors.forename: Zhengkun
authors.initials: Z
authors.lastname: Yu
mesh_terms: D000080:Acetals / Q000737:chemistry*; D000475:Alkenes / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D005030:Ethylenes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000080:Acetals; D000475:Alkenes; D005030:Ethylenes; D007659:Ketones; D013438:Sulfhydryl Compounds; C008223:ketene