title: Noninvasive in vivo liver fibrosis evaluation using supersonic shear imaging: a clinical study on 113 hepatitis C virus patients.
abstract: Supersonic shear imaging (SSI) has recently been demonstrated to be a repeatable and reproducible transient bidimensional elastography technique. We report a prospective clinical evaluation of the performances of SSI for liver fibrosis evaluation in 113 patients with hepatitis C virus (HCV) and a comparison with FibroScan (FS). Liver elasticity values using SSI and FS ranged from 4.50 kPa to 33.96 kPa and from 2.60 kPa to 46.50 kPa, respectively. Analysis of variance (ANOVA) shows a good agreement between fibrosis staging and elasticity assessment using SSI and FS (p < 10(-5)). The areas under receiver operating characteristic (ROC) curves for elasticity values assessed from SSI were 0.948, 0.962 and 0.968 for patients with predicted fibrosis levels F ≥ 2, F ≥ 3 and F = 4, respectively. These values are compared with FS area under the receiver operating characteristic curve (AUROC) of 0.846, 0.857 and 0.940, respectively. This comparison between ROC curves is particularly significant for mild and intermediate fibrosis levels. SSI appears to be a fast, simple and reliable method for noninvasive liver fibrosis evaluation.
authors.affiliation: Institut Langevin-Ondes et Images, ESPCI ParisTech (UMR CNRS 7587/INSERM U979), Paris, France. eric.bavu@espci.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Bavu
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Gennisson
authors.forename: Mathieu
authors.initials: M
authors.lastname: Couade
authors.forename: Jeremy
authors.initials: J
authors.lastname: Bercoff
authors.forename: Vincent
authors.initials: V
authors.lastname: Mallet
authors.forename: Mathias
authors.initials: M
authors.lastname: Fink
authors.forename: Anne
authors.initials: A
authors.lastname: Badel
authors.forename: Anaïs
authors.initials: A
authors.lastname: Vallet-Pichard
authors.forename: Bertrand
authors.initials: B
authors.lastname: Nalpas
authors.forename: Mickaël
authors.initials: M
authors.lastname: Tanter
authors.forename: Stanislas
authors.initials: S
authors.lastname: Pol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D019540:Area Under Curve; D054459:Elasticity Imaging Techniques; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000000981:diagnostic imaging*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000821:virology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012372:ROC Curve