title: Digallic acid from Pistascia lentiscus fruits induces apoptosis and enhances antioxidant activities.
abstract: The antioxidant and apoptotic activities of digallic acid, isolated from the fruits of Pistascia lentiscus, were investigated. The study demonstrated that digallic acid possessed pro-apoptotic effects, as shown by provoking DNA fragmentation of K562 cells. It also revealed a significant antioxidant potential and effective scavenging activity against 2,2-diphenyl-1-picrylhdrazyl (DPPH·) and O₂·⁻ radicals, and reduced cupric ions. We conclude that this integrated approach to apoptotic and antioxidant assessment may be useful to maximize the beneficial effects associated with using P. lentiscus derivatives as medicinal and dietary compounds.
authors.affiliation: Laboratoire de biologie Cellulaire et Moléculaire Faculté de Medecine Dentaire Monastir, Rue Avicenne 5000, Tunisia.
authors.forename: Wissem
authors.initials: W
authors.lastname: Bhouri
authors.forename: Ines
authors.initials: I
authors.lastname: Skandrani
authors.forename: Mohamed Ben
authors.initials: MB
authors.lastname: Sghair
authors.forename: Marie-Geneviève Djoux
authors.initials: MG
authors.lastname: Franca
authors.forename: Kamel
authors.initials: K
authors.lastname: Ghedira
authors.forename: Leila Chekir
authors.initials: LC
authors.lastname: Ghedira
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry*; D017209:Apoptosis; D001713:Biphenyl Compounds / Q000737:chemistry; D053938:DNA Fragmentation; D053630:Depsides / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D010851:Picrates / Q000737:chemistry; D027927:Pistacia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012256:Riboflavin / Q000737:chemistry; D013482:Superoxide Dismutase / Q000737:chemistry; D013778:Tetrazolium Salts / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001713:Biphenyl Compounds; D053630:Depsides; D010851:Picrates; D010936:Plant Extracts; D013778:Tetrazolium Salts; C067648:digallic acid; D005707:Gallic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D013482:Superoxide Dismutase; D012256:Riboflavin