title: Case-control studies for identifying novel teratogens.
abstract: The case-control study design offers an operationally efficient approach to measuring an association between an exposure and an outcome, especially when the outcome is rare, as is true for specific birth defects. For example, instead of following 50,000 pregnant women to have sufficient statistical power to identify a doubling in risk of oral clefts associated with a common exposure (e.g., cigarette smoking), 75 cases and 3 controls per case could be studied with equal statistical power. Examples of case sources include hospital or clinical series, or birth defect registries. For validity, control subjects should represent the population base of the cases, which can be difficult to identify for non-population-based case groups. Case-control studies typically rely on retrospective exposure measurement, which presents a major challenge and sets up the possibility of recall bias. Approaches are discussed to keep sources of bias to a minimum, including recall, non-differential information, and selection biases. Case-control studies can play an important role in this process for both hypothesis-generation and hypothesis-testing of potential teratogens. Examples of case-control studies and their contributions to the field are presented. © 2011 Wiley-Liss, Inc.
authors.affiliation: Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA. werler@bu.edu
authors.forename: Martha M
authors.initials: MM
authors.lastname: Werler
authors.forename: Carol
authors.initials: C
authors.lastname: Louik
authors.forename: Allen A
authors.initials: AA
authors.lastname: Mitchell
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011247:Pregnancy; D012042:Registries; D012107:Research Design; D015983:Selection Bias; D012907:Smoking / Q000009:adverse effects; D013723:Teratogens
chemical_list: D013723:Teratogens