title: Crosstalk in NF-κB signaling pathways.
abstract: NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn mediate varied transcriptional programs. Consequently, NF-κB-dependent transcription is not only tightly controlled by positive and negative regulatory mechanisms but also closely coordinated with other signaling pathways. This intricate crosstalk is crucial to shaping the diverse biological functions of NF-κB into cell type- and context-specific responses.
authors.affiliation: Department of Microbiology & Immunology, Columbia University, College of Physicians & Surgeons, New York, New York, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Oeckinghaus
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Hayden
authors.forename: Sankar
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D006801:Humans; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D015533:Transcriptional Activation
chemical_list: D016328:NF-kappa B