title: Inflammation related to synovectomy during total knee replacement in patients with primary osteoarthritis: a prospective, randomised study.
abstract: We compared inflammation in the knee after total knee replacement (TKR) for primary osteoarthritis between two groups of patients undergoing joint replacement with and without synovectomy. A total of 67 patients who underwent unilateral TKR were randomly divided into group I, TKR without synovectomy, and group II, TKR with synovectomy. Clinical outcomes, serial serum inflammatory markers (including interleukin-6 (IL-6), CRP and ESR) and the difference in temperature of the skin of the knee, compared with the contralateral side, were sequentially evaluated until 26 weeks after surgery. Pre-operatively, there were no statistically different clinical parameters between groups I and II. At the 26-week follow-up, both groups had a similarly significantly improved American Knee Society clinical score (p < 0.001) and functional score (p < 0.001) with no differences between the groups. Similar changes in serial inflammatory markers were found in both groups, including mean peak levels of IL-6 (189 pg/ml (SD 53.4) versus 201 pg/ml (SD 49.4) for groups I and II, respectively) and CRP (91 mg/L (SD 24.1) versus 88 mg/L (SD 23.4), respectively) on the first post-operative day, returning to pre-operative values at two and six weeks, respectively. The mean peak level of ESR for the respective two groups was 46 mm/hr versus 48 mm/hr at two weeks, which had still not returned to its pre-operative mean value at 26 weeks. The elevation in the skin temperature appeared to mirror the peak elevation of the ESR, with a range of 2.5° C to 4.5° C with some reduction at 26 weeks but still exceeding the pre-operative value. We concluded that synovectomy at the time of TKR does not provide any benefit to the clinical outcome or shorten the duration of the inflammatory response after surgery.
authors.affiliation: Department of Orthopaedics, Chulalongkorn University, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand. areetana@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Tanavalee
authors.forename: S
authors.initials: S
authors.lastname: Honsawek
authors.forename: T
authors.initials: T
authors.lastname: Rojpornpradit
authors.forename: M
authors.initials: M
authors.lastname: Sakdinakiattikoon
authors.forename: S
authors.initials: S
authors.lastname: Ngarmukos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000601:surgery*; D011184:Postoperative Period; D012881:Skin Temperature; D000074402:Synovectomy; D013585:Synovitis / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D002097:C-Reactive Protein