title: Systemic features of immune recognition in the gut.
abstract: The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.
authors.affiliation: Scuola Europea di Medicina Molecolare (SEMM), Campus IFOM-IEO, Via Adamello 16, 20139 Milan, Italy. bartlomiej.swiatczak@ifom-ieo-campus.it
authors.forename: Bartlomiej
authors.initials: B
authors.lastname: Swiatczak
authors.forename: Maria
authors.initials: M
authors.lastname: Rescigno
authors.forename: Irun R
authors.initials: IR
authors.lastname: Cohen
mesh_terms: D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity; D018407:Bacterial Physiological Phenomena; D018988:Bacterial Translocation / Q000276:immunology; D041981:Gastrointestinal Tract / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology; D009092:Mucous Membrane / Q000276:immunology; D049490:Systems Biology