title: Application of a new amidophosphite ligand to Rh-catalyzed asymmetric hydrogenation of β-dehydroamino acid derivatives in supercritical carbon dioxide: activation effect of protic Co-solvents.
abstract: New chiral amidophosphite ligand was synthesized and tested in the Rh-catalyzed asymmetric hydrogenation of (Z)-β-(acylamino)acrylates in protic solvents and supercritical carbon dioxide (scCO(2) ) The catalytic performance is affected greatly by the acidity of the solvents. Better enantioselectivity (up to 88% ee) was achieved in scCO(2) containing 1,1,1,3,3,3-hexafluoro-2-propanol, compared to neat protic solvents.
authors.affiliation: Institute of Organoelement Compounds, Russian Academy of Sciences, 119991 Moscow, Russia. lssp452@mail.ru
authors.forename: Sergey E
authors.initials: SE
authors.lastname: Lyubimov
authors.forename: Eugenie A
authors.initials: EA
authors.lastname: Rastorguev
authors.forename: Vadim A
authors.initials: VA
authors.lastname: Davankov
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D008024:Ligands; D009943:Organophosphorus Compounds; D012997:Solvents; C434331:phosphoramidite; D002245:Carbon Dioxide; D012238:Rhodium