title: Transgenic mouse models and prion strains.
abstract: Here we review the known strain profiles of various prion diseases of animals and humans, and how transgenic mouse models are being used to elucidate basic molecular mechanisms of prion propagation and strain variation and for assessing the zoonotic potential of various animal prion strains.
authors.affiliation: Sanders Brown Center on Aging, University of Kentucky Medical Center, Lexington, KY 40506, USA. gtell2@uky.edu
authors.forename: Glenn C
authors.initials: GC
authors.lastname: Telling
mesh_terms: D000818:Animals; D002417:Cattle; D003670:Deer; D004195:Disease Models, Animal; D005838:Genotype; D006041:Goats; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D017096:Prion Diseases / Q000235:genetics* / Q000378:metabolism; D011328:Prions / Q000378:metabolism*; D012756:Sheep; D013045:Species Specificity; D015047:Zoonoses
chemical_list: D011328:Prions