title: Isoiridomyrmecin rich essential oil from Nepeta erecta Benth. and its antioxidant activity.
abstract: The essential oil composition of the aerial parts of Nepeta erecta Benth. (Family: Lamiaceae) from Uttarakhand, India was analysed by capillary gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 34 constituents were identified representing 94.6% of the oil composition. Oxygenated monoterpenes (74.0%) constituted the major proportion of the oil, dominated by isoiridomyrmecin (70.6%) as a single major constituent. Other significant constituents were caryophyllene oxide (9.6%), β-Bourbonene (2.0%), humulene epoxide II (1.7%) and linalool (1.0%). The in vitro antioxidant activity (AOA) was assessed using β-Carotene bleaching assay, reducing power, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and inhibition of lipid peroxidation methods. The oil was found to exhibit AOA by inhibiting β-Carotene bleaching (54.6 ± 2.52%) and by scavenging DPPH free radical (IC(50) = 0.74 ± 0.12 mg mL(-1)). The AOA of the essential oil of N. erecta and its major compound isoiridomyrmecin has not been reported so far.
authors.affiliation: Department of Chemistry, Kumaun University, Uttarakhand, India.
authors.forename: Dinesh S
authors.initials: DS
authors.lastname: Bisht
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Joshi
authors.forename: Rajendra C
authors.initials: RC
authors.lastname: Padalia
authors.forename: Chandra S
authors.initials: CS
authors.lastname: Mathela
mesh_terms: D000080462:Acyclic Monoterpenes; D000975:Antioxidants / Q000032:analysis* / Q000737:chemistry; D001713:Biphenyl Compounds; D002849:Chromatography, Gas; D008401:Gas Chromatography-Mass Spectrometry; D007194:India; D039823:Iridoids / Q000032:analysis* / Q000737:chemistry; D015394:Molecular Structure; D039821:Monoterpenes / Q000032:analysis; D027521:Nepeta / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry*; D010851:Picrates; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000032:analysis
chemical_list: D000080462:Acyclic Monoterpenes; D000975:Antioxidants; D001713:Biphenyl Compounds; D039823:Iridoids; D039821:Monoterpenes; D009822:Oils, Volatile; D010851:Picrates; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C505329:humulene-4,5-epoxide; C018584:linalool; C004931:1,1-diphenyl-2-picrylhydrazyl; C542377:beta-bourbonene; C515179:caryophyllene oxide