title: Importance of circulating platelet aggregates and haemodynamic changes in ophthalmic artery and progression of visual field loss at pseudoexfoliation glaucoma.
abstract: The aim of this work is to examine the role of circulating platelet aggregates (CPA) at pseudoexfoliation glaucoma (PXG), haemodynamic changes in the ophthalmic artery by ultrasonic color Doppler, searching for visual field progression. Vascular component at PXG and its role in VF progression dynamics has not been sufficiently explained, as well as CPA influence to ischaemic events related to optic nerve damage and VF progression. The examination included 80 patients, where of 35 (44%) men average age 68.3 +/- 7.0 and 45 (56%) women average age 65.7 +/- 7.0 (t = 1.66; p = 0.101). Forthy of them suffered from primary open angle glaucoma (POAG) as a control group (healthy), and 40 from pseudoexfoliative glaucoma (PXG) as an experimental group. All the examinees underwent complete ophthalmological examination: visual acuity, ocular fundus, intraocular pressure measured, anterior eye segment biomicroscopy with gonioscopy performed. Also VF examination was performed three times at 6 months intervals. Laboratory testing of CPA proportion values was performed by means of Wu an Hoak method and ultrasonic measurement of blood perfusion in the carotid tree, particularly concerning ophthalmic artery by means of color Doppler. Obtained decreased values of CPA proportion resulted in hypercoagulability of blood in PXG group. At PXG were also found increased blood flow resistivity indexes in ophthalmic artery (RI AO) and internal carotid artery (RI ACI), resulting with ischemia and hypoxia and finally progression of the visual filed damage. In conclusion, our study shows that examining CPA and ultrasonic monitoring of vascular parameters in ophthalmic artery with color Doppler may be the way of better understanding the vascular role in PXG prognosis.
authors.affiliation: University of Split, Split University Hospital Center, Department of Ophthalmology, Split, Croatia. veljko.rogosic@st.t-com.hr
authors.forename: Veljko
authors.initials: V
authors.lastname: Rogosić
authors.forename: Lovro
authors.initials: L
authors.lastname: Bojić
authors.forename: Lucija Vanjaka
authors.initials: LV
authors.lastname: Rogosić
authors.forename: Marina
authors.initials: M
authors.lastname: Titlić
authors.forename: Mladen
authors.initials: M
authors.lastname: Lesin
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Kovacić
authors.forename: Kolja
authors.initials: K
authors.lastname: Poljak
authors.forename: Darko
authors.initials: D
authors.lastname: Duplancić
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D018450:Disease Progression; D017889:Exfoliation Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005123:Eye / Q000098:blood supply* / Q000503:physiopathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000503:physiopathology*; D010974:Platelet Aggregation / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D018615:Ultrasonography, Doppler, Color; D014794:Visual Fields / Q000502:physiology*