title: Exploration of the host haemostatic system by group A streptococcus: implications in searching for novel antimicrobial therapies.
abstract: The haemostatic system is heavily involved in the host response to infection. A number of host haemostatic factors, notably plasminogen and fibrinogen have been reported to bind and interact with various bacterial proteins. This review summarises the roles of host haemostatic factors such as plasminogen, factor V and fibrinogen in host defence against group A streptococcus infection and discusses the potential of targeting the host haemostatic system for therapeutic intervention against infectious diseases.
authors.affiliation: Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO, USA. sunh@health.missouri.edu
authors.forename: H
authors.initials: H
authors.lastname: Sun
mesh_terms: D000818:Animals; D006487:Hemostasis; D054884:Host-Pathogen Interactions; D013297:Streptococcus pyogenes / Q000472:pathogenicity*