title: Synthesis of novel taspine diphenyl derivatives as fluorescence probes and inhibitors of breast cancer cell proliferation.
abstract: Two novel taspine diphenyl derivatives (Ta-dD) were designed and synthesized by introducing different coumarin fluorescent groups into the basic structure of Ta-dD. The main advantage of these two compounds is that they can be used as fluorescence probes and inhibitors simultaneously. In the present study, the fluorescent properties of the probes were measured and their inhibition of four breast cancer cell lines was tested. Different concentrations of the fluorescence probe were added to MCF-7 breast cancer cells for fluorescence imaging analysis under normal conditions. The results suggested that both of the new compounds have not only fluorescence but also the ability to inhibit effects on different breast cancer cell lines, which indicates their possible further use as dual functional fluorescence probes in tracer analysis.
authors.affiliation: Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, School of Medicine, Xi'an Jiaotong University, People's Republic of China.
authors.forename: Huaizhen
authors.initials: H
authors.lastname: He
authors.forename: Yingzhuan
authors.initials: Y
authors.lastname: Zhan
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Langchong
authors.initials: L
authors.lastname: He
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000737:chemistry / Q000503:physiopathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005260:Female; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000494:pharmacology; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008856:Microscopy, Fluorescence; D061848:Optical Imaging
chemical_list: D000470:Alkaloids; D001713:Biphenyl Compounds; D005456:Fluorescent Dyes; D006131:Growth Inhibitors; C010574:biphenyl; C018394:taspine