title: [Effect of berberine on pharmacokinetics of digoxin after oral administration to rats].
abstract: OBJECTIVE
  To study the effects of berberine (BBR) on the pharmacokinetics of digoxin (DIG) in rats.
  
  
  METHODS
  Rats were randomly assigned into DIG, low dose-BBR, middle dose-BBR and high dose-BBR group. After singe or a 2-week ig pretreatment with BBR, serum DIG concentration was determined by radioimmunoassay. Pharmacokinetic calculations were performed on each individual set of data using 3P97 practical pharmacokinetic software.
  
  
  RESULTS
  No significant difference was found between the control and 10 mg x kg(-1) BBR combined group. After pretreatment with BBR (30, 100 mg x kg(-1)), the pharmacokinetic parameters of ig DIG were significantly altered. The AUC(0-t) of DIG with BBR increased by 33% and 70% (single), 27% and 75% (2-week), respectively.
  
  
  CONCLUSIONS
  BBR increases bioavailability of DIG, which may be related to its inhibition effect on intestinal P-gp.
authors.affiliation: Department of Pharmacy, Lanzhou University Second Hospital, Lanzhou 730030, China. jy0912@sohu.com
authors.forename: Yang
authors.initials: Y
authors.lastname: Ju
authors.forename: Wen
authors.initials: W
authors.lastname: Qiu
authors.forename: Xuehua
authors.initials: X
authors.lastname: Jiang
authors.forename: Changxiao
authors.initials: C
authors.lastname: Liu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D004077:Digoxin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D001599:Berberine; D004077:Digoxin