title: Liver engraftment potential of hepatic cells derived from patient-specific induced pluripotent stem cells.
abstract: Human induced pluripotent stem cells (iPSCs) are potential renewable sources of hepatocytes for drug development and cell therapy. Differentiation of human iPSCs into different developmental stages of hepatic cells has been achieved and improved during the last several years. We have recently demonstrated the liver engraftment and regenerative capabilities of human iPSC-derived multistage hepatic cells in vivo. Here we describe the in vitro and in vivo activities of hepatic cells derived from patient specific iPSCs, including multiple lines established from either inherited or acquired liver diseases, and discuss basic and clinical applications of these cells for disease modeling, drug screening and discovery, gene therapy and cell replacement therapy.
authors.affiliation: Stem Cell Biology Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Su Mi
authors.initials: SM
authors.lastname: Choi
authors.forename: Yonghak
authors.initials: Y
authors.lastname: Kim
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Pooja
authors.initials: P
authors.lastname: Chaudhari
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ye
authors.forename: Yoon-Young
authors.initials: YY
authors.lastname: Jang
mesh_terms: D002454:Cell Differentiation; D064987:Cell- and Tissue-Based Therapy; D004341:Drug Evaluation; D022781:Hepatocytes / Q000166:cytology* / Q000637:transplantation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D008107:Liver Diseases / Q000517:prevention & control / Q000628:therapy