title: Inflammation meets cancer, with NF-κB as the matchmaker.
abstract: Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors. Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology.
authors.affiliation: Lautenberg Center for Immunology, Institute for Medical Research-Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel. yinon@cc.huji.ac.il
authors.forename: Yinon
authors.initials: Y
authors.lastname: Ben-Neriah
authors.forename: Michael
authors.initials: M
authors.lastname: Karin
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000276:immunology*; D016328:NF-kappa B / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*
chemical_list: D016328:NF-kappa B