title: Mammary analogue secretory carcinoma: the first submandibular case reported including findings on fine needle aspiration cytology.
abstract: We present the first case (male, 35 years old) of a mammary analogue secretory carcinoma occurring in a submandibular gland and document findings on fine needle aspiration cytology. On histology, the tumor displayed characteristic features: circumscribed nodules composed of bland, pink to light red neoplastic cells with low proliferative/mitotic activity arranged in tubular, vaguely cribriform, and microcystic structures containing Periodic acid Schiff-positive, diastase-resistant secretory material. Immunohistochemistry showed strong and diffuse positivity for cytokeratin 7, S100 protein, and vimentin, as well as moderate to strong immunoreactivity for c-kit in the majority of tumor cells. A rearrangement of the ETV6 gene on fluorescence in situ hybridization was documented. The patient underwent an ipsilateral selective (levels I-IV) neck dissection which showed metastasis in 3 out of 36 lymph nodes (levels 1-3). Adjuvant radiotherapy was administered. No local recurrence or metastatic disease has been detected during a follow up period of 28 months.
authors.affiliation: Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore. fredrikpetersson@live.se
authors.forename: Fredrik
authors.initials: F
authors.lastname: Petersson
authors.forename: Derrick
authors.initials: D
authors.lastname: Lian
authors.forename: Yuk Ping
authors.initials: YP
authors.lastname: Chau
authors.forename: Benedict
authors.initials: B
authors.lastname: Yan
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D053552:Keratin-7 / Q000378:metabolism; D008297:Male; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics*; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics*; D009418:S100 Proteins / Q000378:metabolism; D013365:Submandibular Gland Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D014746:Vimentin / Q000378:metabolism; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D053552:Keratin-7; D050783:Proto-Oncogene Proteins c-ets; D019009:Proto-Oncogene Proteins c-kit; D012097:Repressor Proteins; D009418:S100 Proteins; D014746:Vimentin; D000097764:ETS Translocation Variant 6 Protein