title: A perhaps unexpected role of norepinephrine in actions of MDMA.
abstract: In this issue, Hysek and colleagues present new data describing the impact of treatment with reboxetine on the effects produced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in human volunteers. They demonstrate that several effects of MDMA are mediated by reboxetine's actions on norepinephrine (NE) transporters, an unexpected finding. Building on earlier work, their new data provide new insights into the pharmacodynamics of MDMA and other monoamine-releasing agents.
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA. tnewton@bcm.edu
authors.forename: T F
authors.initials: TF
authors.lastname: Newton
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D004347:Drug Interactions; D006213:Hallucinogens / Q000494:pharmacology; D006801:Humans; D009025:Morpholines / Q000494:pharmacology*; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000187:drug effects / Q000378:metabolism; D000077593:Reboxetine
chemical_list: D018759:Adrenergic Uptake Inhibitors; D006213:Hallucinogens; D009025:Morpholines; D050484:Norepinephrine Plasma Membrane Transport Proteins; D000077593:Reboxetine; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D009638:Norepinephrine