title: Recent advances in p53 research and cancer treatment.
abstract: TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway. Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumor-promoting effects. The basic function of p53 is to respond to cellular stress. We herein review the recent advances in p53 research and focus on apoptosis, cell cycle arrest, and senescence in response to stress. We also review the clinical applications of p53-based therapy for human cancer.
authors.affiliation: Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. suzuki@chiba-u.jp
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D002453:Cell Cycle / Q000235:genetics*; D004249:DNA Damage; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53 / Q000235:genetics*; D015316:Genetic Therapy; D006801:Humans; D007167:Immunotherapy; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: D016159:Tumor Suppressor Protein p53