title: Estrogen receptor beta stimulates Egr-1 transcription via MEK1/Erk/Elk-1 cascade in C6 glioma cells.
abstract: The Egr-1 is an immediate early response gene encoding a transcription factor that functions in the regulation of cell growth, differentiation, and apoptosis. Estrogen has diverse physiological effects, including cellular proliferation and neuroprotection against brain injury. There are two types of estrogen receptors (ERs), ERα and ERβ. ERα-induced Egr-1 expression has been extensively studied; however, the role of ERβ is yet not known. In the present study, we investigated whether or not ERβ induces Egr-1 expression in C6 rat glioma cells, which express ERβ but not ERα. Our results show that ERβ promoted up-regulation of Egr-1 expression via a non-genomic mechanism involving the Raf/MEK1/Erk/Elk-1 signaling cascade.
authors.affiliation: Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, Korea.
authors.forename: Ji-Ha
authors.initials: JH
authors.lastname: Kim
authors.forename: Il-Yeup
authors.initials: IY
authors.lastname: Jeong
authors.forename: Yoongho
authors.initials: Y
authors.lastname: Lim
authors.forename: Young Han
authors.initials: YH
authors.lastname: Lee
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Shin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D051766:Early Growth Response Protein 1 / Q000235:genetics* / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D005910:Glioma / Q000201:enzymology* / Q000235:genetics; D048369:MAP Kinase Kinase 1 / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D011401:Promoter Regions, Genetic / Q000235:genetics; D051381:Rats; D014158:Transcription, Genetic; D015533:Transcriptional Activation / Q000235:genetics; D050807:ets-Domain Protein Elk-1 / Q000378:metabolism*
chemical_list: D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; C494114:Elk1 protein, rat; D047629:Estrogen Receptor beta; D050807:ets-Domain Protein Elk-1; D048049:Extracellular Signal-Regulated MAP Kinases; D048369:MAP Kinase Kinase 1