title: Chemokines in CSF of Alzheimer's disease patients.
abstract: Some studies have linked the presence of chemokines to the early stages of Alzheimer's disease (AD). Then, the identification of these mediators may contribute to diagnosis. Our objective was to evaluate the levels of beta-amyloid (BA), tau, phospho-tau (p-tau) and chemokines (CCL2, CXCL8 and CXCL10) in the cerebrospinal fluid (CSF) of patients with AD and healthy controls. The correlation of these markers with clinical parameters was also evaluated. The levels of p-tau were higher in AD compared to controls, while the tau/p-tau ratio was decreased. The expression of CCL2 was increased in AD. A positive correlation was observed between BA levels and all chemokines studied, and between CCL2 and p-tau levels. Our results suggest that levels of CCL2 in CSF are involved in the pathogenesis of AD and it may be an additional useful biomarker for monitoring disease progression.
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Jôice Dias
authors.initials: JD
authors.lastname: Corrêa
authors.forename: Daniela
authors.initials: D
authors.lastname: Starling
authors.forename: Antônio Lúcio
authors.initials: AL
authors.lastname: Teixeira
authors.forename: Paulo
authors.initials: P
authors.lastname: Caramelli
authors.forename: Tarcília Aparecida
authors.initials: TA
authors.lastname: Silva
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid; D054357:Chemokine CXCL10 / Q000134:cerebrospinal fluid; D018925:Chemokines / Q000134:cerebrospinal fluid*; D018450:Disease Progression; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D018932:Chemokine CCL2; D054357:Chemokine CXCL10; D018925:Chemokines; D016209:Interleukin-8; D016875:tau Proteins