title: Lorazepam effects on Word Memory Test performance: a randomized, double-blind, placebo-controlled, crossover trial.
abstract: The Word Memory Test (WMT) is a common measure of symptom validity. To investigate the effects of acute benzodiazepines on WMT scores, oral lorazepam 2 mg (LOR) and placebo were administered 1 week apart in a randomized, double-blind, placebo-controlled, crossover study. A total of 28 participants completed the study and were administered the WMT during each drug condition. Within-participant comparisons of LOR vs placebo revealed significant LOR effects for Immediate Recognition (p = .007) and Consistency (p = .019), but not Delayed Recognition (p = .085). Significant LOR effects were present for Reaction Time Measures (Immediate Recognition RT, p = .013; Delayed Recognition RT, p = .001; Multiple Choice RT, p = .011) and Delayed Memory scores (Multiple Choice, p = .007; Paired Associates, p = .029; Free Recall, p = .001). A pattern similar to crossover results was detected for LOR vs placebo between-group differences for initial test assessment scores. When examined using publisher recommended cut scores for the principal WMT measures, there were six participants failing the WMT during initial LOR testing; all six subsequently performed in the normal range upon retesting with placebo. One participant failed WMT during placebo and obtained passing scores during LOR. These data indicate that multiple WMT measures may be affected by acute LOR dosing, and provide additional evidence that potential latent variables and their effects on both SVT performance and cognitive function should be part of the clinical decision-making process.
authors.affiliation: Department of Neurology, Emory University, Atlanta, GA, USA. dloring@emory.eduorma
authors.forename: David W
authors.initials: DW
authors.lastname: Loring
authors.forename: Susan E
authors.initials: SE
authors.lastname: Marino
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Drane
authors.forename: David
authors.initials: D
authors.lastname: Parfitt
authors.forename: Glen R
authors.initials: GR
authors.lastname: Finney
authors.forename: Kimford J
authors.initials: KJ
authors.lastname: Meador
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016001:Confidence Intervals; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D018757:GABA Modulators / Q000494:pharmacology*; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000187:drug effects; D014825:Vocabulary; D055815:Young Adult
chemical_list: D018757:GABA Modulators; D008140:Lorazepam