title: Periodic mesoporous organosilicas with controlled pore symmetries for peptides enrichment.
abstract: Periodic mesoporous organosilicas (PMOs) with controlled structures have been synthesized by using cetyltrimethylammonium bromide (CTAB) and sodium perfluorooctanoate (PFONa) as co-templates, 1,2-bis (triethoxysilyl)ethane (BTEE) as an organosilica precursor. By increasing the weight ratio of PFONa/CTAB, a structure transformation from a cubic (Pm-3n) to a two-dimensional hexagonal (p6m) mesostructure and then to multilamellar vesicles can be observed. The cubic and hexagonal samples have similar particle size (200-750 nm), pore size (2.6 and 2.8 nm, respectively), total pore volume (approximately 0.7 cm3/g), and surface area (approximately 900 m2/g), providing ideal candidates to study the peptide enrichment performance influenced simply by pore symmetries. Matrix-assisted laser desorption ionization time-of-flight mass spectroscopy (MALDI-TOF MS) analysis indicates that PMO with a cubic (Pm-3n) structure is more effective in small molecular weight peptides enrichment compared with PMO with a hexagonal structure, showing the importance of mesostructural control for targeted applications. The phenomena can be attributed to the cage-type structure of the Pm-3n symmetry, which possesses cages with a relatively larger pore size and connectivity with a relatively smaller size. It is suggested that the pore entrances with small size are responsible for entrapping small molecular weight peptides. Our study may shed light on the designed synthesis of functional porous materials with controlled structures and enhanced performance in peptides enrichment.
authors.affiliation: Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Pei
authors.initials: P
authors.lastname: Yuan
authors.forename: Jing Jing
authors.initials: JJ
authors.lastname: Wan
authors.forename: Kun
authors.initials: K
authors.lastname: Qian
authors.forename: Guang Feng
authors.initials: GF
authors.lastname: Wei
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Bao Hong
authors.initials: BH
authors.lastname: Liu
authors.forename: Yun Hua
authors.initials: YH
authors.lastname: Wang
authors.forename: Cheng Zhong
authors.initials: CZ
authors.lastname: Yu
mesh_terms: D000818:Animals; D002417:Cattle; D006736:Horses; D008854:Microscopy, Electron; D008970:Molecular Weight; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D017646:Organosilicon Compounds / Q000737:chemistry*; D010316:Particle Size; D010446:Peptide Fragments / Q000302:isolation & purification*; D016062:Porosity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D017646:Organosilicon Compounds; D010446:Peptide Fragments