title: Death-associated protein kinase 1 variation and Parkinson's disease.
abstract: OBJECTIVE
  Mutations of the LRRK2 gene are now recognized as major risk factors for Parkinson's disease. The Lrrk2 protein is a member of the ROCO family, which also includes Lrrk1 and Dapk1. Functional genetic variants of the DAPK1 gene (rs4877365 and rs4878104) have been previously associated with Alzheimer's disease.
  
  
  METHODS
  Herein, we assessed the role of DAPK1 variants (rs4877365 and rs4878104) in risk of Parkinson's disease with Sequenom iPLEX genotyping, employing one Taiwanese series (391 patients with Parkinson's disease, 344 controls) and five separate Caucasian series' (combined sample size 1962 Parkinson's disease patients, 1900 controls).
  
  
  RESULTS
  We observed no evidence of association for rs4877365 and rs4878104 and risk of Parkinson's disease in any of the individual series or in the combined Caucasian series under either an additive or recessive model.
  
  
  CONCLUSIONS
  These specific DAPK1 intronic variants do not increase the risk of Parkinson's disease. However, further functional studies are required to elucidate the potential therapeutic implications with the dimerization of the Dapk1 and Lrrk2 proteins.
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Dachsel
authors.forename: C
authors.initials: C
authors.lastname: Wider
authors.forename: C
authors.initials: C
authors.lastname: Vilariño-Güell
authors.forename: J O
authors.initials: JO
authors.lastname: Aasly
authors.forename: A
authors.initials: A
authors.lastname: Rajput
authors.forename: A H
authors.initials: AH
authors.lastname: Rajput
authors.forename: T
authors.initials: T
authors.lastname: Lynch
authors.forename: D
authors.initials: D
authors.lastname: Craig
authors.forename: A
authors.initials: A
authors.lastname: Krygowska-Wajs
authors.forename: B
authors.initials: B
authors.lastname: Jasinska-Myga
authors.forename: G
authors.initials: G
authors.lastname: Opala
authors.forename: M
authors.initials: M
authors.lastname: Barcikowska
authors.forename: K
authors.initials: K
authors.lastname: Czyzewski
authors.forename: R-M
authors.initials: RM
authors.lastname: Wu
authors.forename: M G
authors.initials: MG
authors.lastname: Heckman
authors.forename: R J
authors.initials: RJ
authors.lastname: Uitti
authors.forename: Z K
authors.initials: ZK
authors.lastname: Wszolek
authors.forename: M J
authors.initials: MJ
authors.lastname: Farrer
authors.forename: O A
authors.initials: OA
authors.lastname: Ross
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics*; D016022:Case-Control Studies; D064550:Death-Associated Protein Kinases; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055503:Protein Multimerization; D055815:Young Adult
chemical_list: D051017:Apoptosis Regulatory Proteins; C579096:DAPK1 protein, human; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases