title: Effects of exogenous antioxidants on oxidative stress in pregnancy.
abstract: OBJECTIVE
  The present study evaluated the effects on gestation, in terms of oxidative stress, of two antioxidant factors-vitamin E and coenzyme Q10-during pregnancy, with the purpose of applying the results in further human clinical practice.
  
  
  METHODS
  For each aspect we have studied, we used three types of female rats of Wistar race (un-pregnant, primiparous, multiparous), divided in 10 rats/group. From the blood we have sampled, we have determined the oxidative stress (OS) markers: malondialdehyde (MDA) and carbonylated proteins (CP), but also the markers of the antioxidant defense: the hydrogen donor capacity of the plasma (HD) and the sulfhydryl groups (SH).
  
  
  RESULTS
  Vitamin E administration determines significant decreases of MDA and significant increases of CP and HD at primiparous, and also significant increases of SH groups at multiparous. In the case of pregnant animals that received CoQ10 in antioxidant complexes, we have observed an increase of oxidative stress (OS)-MDA in primiparous and CP in multiparous.
  
  
  CONCLUSIONS
  In the case of Vitamin E, taking into account the benefits on redox homeostasis, the decrease of OS, the authors recommend vitamin E administration during pregnancy. However, because of the increase of the OS in the case of pregnant animals, the authors do not recommend the administration of CoQ(10) in antioxidant complexes during pregnancy.
authors.affiliation: Department of Medical Psychology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: M L
authors.initials: ML
authors.lastname: Staicu
authors.forename: A
authors.initials: A
authors.lastname: Mureşan
authors.forename: S
authors.initials: S
authors.lastname: Tache
authors.forename: R
authors.initials: R
authors.lastname: Moldovan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006859:Hydrogen / Q000097:blood; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D011247:Pregnancy; D050050:Protein Carbonylation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000378:metabolism; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D013438:Sulfhydryl Compounds; D014451:Ubiquinone; D014810:Vitamin E; D008315:Malondialdehyde; D006859:Hydrogen; C024989:coenzyme Q10