title: Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models.
abstract: Although there is evidence for the anti-inflammatory activity of nicotinamide, there is no evaluation of its effects in models of nociceptive and inflammatory pain. In addition, there is no information about the potential anti-inflammatory and antinociceptive activities of the nicotinamide isomers, picolinamide and isonicotinamide. Per os (p.o.) administration of nicotinamide (1000 mg/kg, -1h) inhibited the first and second phases of the nociceptive response induced by formalin in mice. In the model of nociceptive pain, exposure of mice to a hot-plate (50°C), nicotinamide (1000 mg/kg, -1h) also presented antinociceptive activity. Nicotinamide (500 mg/kg, -1 and 3h) also inhibited the mechanical allodynia induced by carrageenan in rats, a model of inflammatory pain. In addition to inhibiting the nociceptive response, nicotinamide (500 or 1000 mg/kg, -1 and 3h) inhibited the paw edema induced by carrageenan in mice and rats. P.o. administration of picolinamide (125 mg/kg, -1h) and isonicotinamide (500 or 1000 mg/kg, -1h) inhibited the second phase of the nociceptive response induced by formalin in mice. The paw edema induced by carrageenan in mice was also inhibited by isonicotinamide (500 or 1000 mg/kg, -1h) and picolinamide (125 mg/kg, -1h and 3h). The results represent the first demonstration of the activity of nicotinamide and its isomers in models of nociceptive and inflammatory pain and provide support to their anti-inflammatory activity. The demonstration of new activities for nicotinamide is important as it may contribute to expand its use in the treatment of other pathological conditions.
authors.affiliation: Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901, Belo Horizonte, MG, Brazil.
authors.forename: Adriana M
authors.initials: AM
authors.lastname: Godin
authors.forename: Wallace C
authors.initials: WC
authors.lastname: Ferreira
authors.forename: Leonardo Tadeu S
authors.initials: LT
authors.lastname: Rocha
authors.forename: João Gabriel T
authors.initials: JG
authors.lastname: Seniuk
authors.forename: André Luiz L
authors.initials: AL
authors.lastname: Paiva
authors.forename: Leonardo A
authors.initials: LA
authors.lastname: Merlo
authors.forename: Elias B
authors.initials: EB
authors.lastname: Nascimento
authors.forename: Leandro F S
authors.initials: LF
authors.lastname: Bastos
authors.forename: Márcio M
authors.initials: MM
authors.lastname: Coelho
mesh_terms: D000577:Amides / Q000494:pharmacology; D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D004177:Dipyrone / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005557:Formaldehyde; D006358:Hot Temperature; D007536:Isomerism; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D010848:Picolinic Acids / Q000494:pharmacology; D000071137:Poly (ADP-Ribose) Polymerase-1; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000577:Amides; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010848:Picolinic Acids; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D005557:Formaldehyde; D009536:Niacinamide; C027681:isonicotinamide; D004177:Dipyrone; D002351:Carrageenan; C499321:Parp1 protein, mouse; C499322:Parp1 protein, rat; D000071137:Poly (ADP-Ribose) Polymerase-1; C003142:picolinamide