title: Prevalence of peripheral neuropathy in multiple myeloma at initial diagnosis.
abstract: To evaluate the presence of peripheral neuropathy (PN) in newly diagnosed treatment-naive patients with multiple myeloma (MM), 29 patients and 25 age and sex matched controls underwent electrophysiological studies. Patients with associated diabetes, alcoholism, peripheral vascular disease and POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M component and skin changes) were excluded from the study. The median age of patients was 56 years (range 28-82) and the sex ratio was 2.6:1. Eighteen (62.1%) patients were found to have evidence of PN by history and clinical examination alone (two patients), both clinical and electrophysiological evidence (five patients) and only electrophysiological evidence (11 patients). Out of 25 healthy controls, only two patients had evidence of PN by electrophysiological studies (cases vs. controls, p < 0.002). The commonest nerve involvement was in the form of sensory-motor axonal neuropathy followed by sensory-motor demyelinating neuropathy. This information may impact therapeutic and prognostic decision-making in newly diagnosed patients with MM.
authors.affiliation: Department of Internal Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh, India. malhotrapankaj@hotmail.com
authors.forename: Pankaj
authors.initials: P
authors.lastname: Malhotra
authors.forename: Partha Prateem
authors.initials: PP
authors.lastname: Choudhary
authors.forename: Vivek
authors.initials: V
authors.lastname: Lal
authors.forename: Neelam
authors.initials: N
authors.lastname: Varma
authors.forename: Vikas
authors.initials: V
authors.lastname: Suri
authors.forename: Subhash
authors.initials: S
authors.lastname: Varma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D004594:Electrophysiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D011446:Prospective Studies