title: Bisphosphonate therapy in children with secondary osteoporosis.
abstract: BACKGROUND
  Increased bone fragility requiring effective treatments is a complication of various chronic conditions in children. Bisphosphonates, highly effective in the treatment of adults with osteoporosis, have also been used in children with secondary osteoporosis. However, results obtained in adults cannot be readily extrapolated to children due to differences in the pathophysiology and progression of the disease as well as in the pharmacokinetics of bisphosphonates.
  
  
  CONCLUSIONS
  Available results of studies of bisphosphonates in children with secondary osteoporosis do not yet support their recommendation as standard therapy. Their use should be restricted to patients with fragility fractures and low bone mass.
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands. S.E.Papapoulos@lumc.nl
authors.forename: Socrates E
authors.initials: SE
authors.lastname: Papapoulos
mesh_terms: D015519:Bone Density / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects; D001847:Bone Diseases / Q000150:complications*; D002648:Child; D004164:Diphosphonates / Q000493:pharmacokinetics / Q000627:therapeutic use*; D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D010024:Osteoporosis / Q000209:etiology*
chemical_list: D004164:Diphosphonates