title: Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial.
abstract: OBJECTIVE
  Platelet-rich fibrin (PRF) may be considered as a second-generation platelet concentrate widely used to accelerate soft and hard tissue healing because of presence of many growth factors. The present study aimed to investigate the clinical and radiological effectiveness of autologous PRF in the treatment of intra-bony defects of chronic periodontitis patients.
  
  
  METHODS
  Thirty-two intra-bony defects (one site/patient) were treated either with autologous PRF or a conventional open flap debridement alone. Clinical parameters such as plaque index (PI), sulcus bleeding index (SBI), probing depth (PD), clinical attachment level (CAL) and gingival marginal level (GML) were recorded at baseline and 9 months post-operatively. In both the groups, by using the image analysis software intra-bony defect fill was calculated on standardized radiographs (from the baseline and 9 months).
  
  
  RESULTS
  For all clinical and radiographic parameters test group was performed better than control group, and the difference was found to be statistically significant. Furthermore, images analysis revealed significantly greater bone fill in the test group compared with control (46.92%versus 28.66 %). Mean PD reduction (4.56 ± 0.37>3.56 ± 0.27) and CAL gain (3.69 ± 0.44>2.13 ± 0.43) in test group was found to be more compared with that of control group. In the test group, PD of >4 mm has highest percentage of PD reduction (68.9%) and CAL gain (61.6%). On frequency distribution analysis, there was no more difference for PD reduction in both the groups but CAL gain was much more in the test group than the control group.
  
  
  CONCLUSIONS
  Within the limit of the present study, there was greater reduction in PD, more CAL gain and greater intra-bony defect fill at sites treated with PRF than the open flap debridement alone.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Fort, Bangalore, Karnataka, India. manojpals@gmail.com
authors.forename: Manojkumar
authors.initials: M
authors.lastname: Thorat
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
authors.forename: Borse
authors.initials: B
authors.lastname: Pallavi
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000704:Analysis of Variance; D001792:Blood Platelets; D001861:Bone Regeneration; D055113:Chronic Periodontitis / Q000000981:diagnostic imaging / Q000601:surgery*; D003774:Dental Plaque Index; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006133:Growth Substances / Q000008:administration & dosage; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D057747:Periodontal Debridement; D010512:Periodontal Index; D011859:Radiography; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D006133:Growth Substances; D005337:Fibrin