title: Return to homeostasis: downregulation of NF-κB responses.
abstract: Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.
authors.affiliation: Institut für Molekulare Immunologie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. jruland@lrz.tum.de
authors.forename: Jürgen
authors.initials: J
authors.lastname: Ruland
mesh_terms: D000818:Animals; D015536:Down-Regulation / Q000276:immunology; D005246:Feedback; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D014158:Transcription, Genetic / Q000276:immunology; D015533:Transcriptional Activation / Q000276:immunology
chemical_list: D016328:NF-kappa B