title: Functional inflammatory genotypes in ischemic stroke: could we use them to predict age of onset and long-term outcome?
abstract: Functional single-nucleotide polymorphisms (SNPs) of inflammatory cytokines have been previously related to the occurrence of an ischemic stroke (IS). We investigated whether five functional SNPs (i.e., TNF-α-308G>A, IL6-174G>C, IL12B 1188A>C, IL4-589C>T, and IL10-1082G>A) might be associated with the age of onset and 6-month outcome of an acute IS. A probe-free real-time PCR methodology was used to genotype 145 consecutively admitted cases with a first-ever IS. Simple Kaplan-Mayer and adjusted Cox regression analyses showed no association between inflammatory genotypes and the age of IS onset. IL6-174G>C, IL12B 1188A>C, IL4-589C>T, and IL10-1082G>A were not found to significantly contribute to the long-term outcome of the disease. However, carriage of the TNF-α-308 GG genotype was significantly associated with reduced odds for an adverse outcome. Larger studies are needed to confirm our results.
authors.affiliation: Department of Neurology, University Hospital of Patras, 26500 Rion, Patras, Greece.
authors.forename: Stella
authors.initials: S
authors.lastname: Marousi
authors.forename: Anna
authors.initials: A
authors.lastname: Antonacopoulou
authors.forename: Haralambos
authors.initials: H
authors.lastname: Kalofonos
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Papathanasopoulos
authors.forename: Marina
authors.initials: M
authors.lastname: Karakantza
authors.forename: John
authors.initials: J
authors.lastname: Ellul