title: Effect of pregabalin on post-dural-puncture headache following spinal anesthesia and lumbar puncture.
abstract: In this study, we aimed to investigate the effect of pregabalin on post-dural-puncture headache (PDPH). Forty patients who developed PDPH after spinal anesthesia or diagnostic and/or therapeutic lumbar puncture were divided into two groups and followed for 5 days. The first group received 150 mg/day oral pregabalin for the first 3 days, then 300 mg/day for a further 2 days. The second group received a placebo for the same length of time. Patient headaches were scored using the visual analog scale, and diclofenac sodium and pethidine requirements were recorded. Relative to the placebo group, the group administered pregabalin had significantly lower visual analog scale scores after the second day of treatment, and had significantly lower diclofenac sodium requirements. Our results indicate that pregabalin may be useful for the management of PDPH.
authors.affiliation: Department of Anaesthesiology, Kafkas University Faculty of Medicine, Kars, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Huseyinoglu
authors.forename: N
authors.initials: N
authors.lastname: Huseyinoglu
authors.forename: E
authors.initials: E
authors.lastname: Hamurtekin
authors.forename: H
authors.initials: H
authors.lastname: Aygun
authors.forename: B
authors.initials: B
authors.lastname: Sulu
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D051299:Post-Dural Puncture Headache / Q000188:drug therapy* / Q000209:etiology; D000069583:Pregabalin; D011446:Prospective Studies; D016037:Single-Blind Method; D013129:Spinal Puncture / Q000009:adverse effects*; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid