title: Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek Population.
abstract: Background. The role of genetic factors in the predisposition to develop ischemic stroke has been assessed by previous studies. The main goal of the current study was to determine any possible role of TNF-857C>T,TNFRSF1A36A>G, and TNFRSF1B676T>G polymorphisms in risk for stroke. Materials and Methods. One hundred seventy-three patients with first ever ischemic stroke of solely atherosclerotic etiology in Northwest Greece and a control group of 179 healthy unrelated subjects were evaluated. Results. TNFα-857TT, TNFR136AA, and TNFR2676TT genotypes were significantly increased in the patient group compared to controls (P = .008, OR = 2.47 (1.26-4.84), P = .005, OR = 1.97 (1.22-3.17), and P = .003, OR = 2.2 (1.43-3.37), resp.). In addition, the TNFR136A and the TNFR2676T alleles were found significantly increased in patients compared to controls (P = .009, OR = 1.48 (1.1-2) and P = .001, OR = 1.75 (1.25-2.46), resp.). Conclusion. The high incidence of these genotypes and alleles in patient group suggests that they are potentially predisposing factors for stroke in the Greek population studied. Large-scale multicenter controlled studies are needed to verify these polymorphisms effects on stroke susceptibility.
authors.affiliation: Department of Neurology, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, Greece.
authors.forename: Sofia
authors.initials: S
authors.lastname: Markoula
authors.forename: Anthoula
authors.initials: A
authors.lastname: Chatzikyriakidou
authors.forename: Sotirios
authors.initials: S
authors.lastname: Giannopoulos
authors.forename: Kargiotis
authors.initials: K
authors.lastname: Odysseas
authors.forename: Sofia
authors.initials: S
authors.lastname: Markou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vemmos
authors.forename: Ioannis
authors.initials: I
authors.lastname: Georgiou
authors.forename: Athanassios P
authors.initials: AP
authors.lastname: Kyritsis