title: Resonance light scattering as a powerful tool for sensitive detection of β-amyloid peptide by gold nanoparticle probes.
abstract: A novel biosensing strategy has been developed for sensitive detection of β-amyloid 1-42 (Aβ(1-42)) down to the ng mL(-1) level in both aqueous solution and diluted human plasma, which is based on measuring changes in resonance light scattering of streptavidin functionalized gold nanoparticles as a function of the concentration of Aβ(1-42) with a conventional spectrofluorometer.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
authors.forename: Chengke
authors.initials: C
authors.lastname: Wang
authors.forename: Dianjun
authors.initials: D
authors.lastname: Liu
authors.forename: Zhenxin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D016229:Amyloid beta-Peptides / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D001710:Biotin / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry*; D010446:Peptide Fragments / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D012542:Scattering, Radiation; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C433241:amyloid beta-protein (1-16); C075222:amyloid beta-protein (1-42); D001710:Biotin; D006046:Gold