title: VEGF-induced angiogenesis ameliorates the memory impairment in APP transgenic mouse model of Alzheimer's disease.
abstract: Vascular endothelial growth factor (VEGF) was investigated in the present study to see whether it could provide a therapeutic opportunity for the treatment of Alzheimer's disease (AD). PDGF-hAPP(V717I) transgenic mice were treated with VEGF or PBS by intraperitoneal injection for three consecutive days. The results showed that VEGF ameliorated the memory impairment of mice, accompanied by CD34(+) cells increasing in peripheral blood, vWF(+) vessels increasing in hippocampus, and CD34(+)/VEGFR2(+), vWF(+)/VEGFR2(+) and BrdU(+)/vWF(+) cells expressing in hippocampus. Furthermore, the level of choline acetyltransferase (ChAT) was considerably enhanced and Aβ deposition was decreased in the brains of mice upon VEGF treatment. These observations suggest that VEGF should be pursued as a novel therapeutic agent for treatment of AD.
authors.affiliation: Department of Neurology, The Second Hospital of Shandong University, 247#, Beiyuan Dajie, Jinan 250033, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Zhao-Hong
authors.initials: ZH
authors.lastname: Xie
authors.forename: Yu-Ji
authors.initials: YJ
authors.lastname: Guo
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Zhao
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Zheng-Yu
authors.initials: ZY
authors.lastname: Zhu
authors.forename: Chao
authors.initials: C
authors.lastname: Lai
authors.forename: Shun-Liang
authors.initials: SL
authors.lastname: Xu
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Bi
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001921:Brain / Q000098:blood supply*; D004195:Disease Models, Animal; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology; D051379:Mice; D008822:Mice, Transgenic; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010982:Platelet-Derived Growth Factor / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000627:therapeutic use*
chemical_list: D016564:Amyloid beta-Protein Precursor; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A