title: [The epidemiology and genetic of gout].
abstract: Gout affects 1-2% of adults in developed countries, where it is the most common inflammatory arthritis in men. Epidemiological data are consistent with a rise in the prevalence of gout. Diet and genetic predisposition seem to be the main causal factors of primary gout. Gout and hyperuricaemia are associated with hypertension, diabetes mellitus, metabolic syndrome, and renal and cardiovascular diseases. Genetic studies have found that variants of GLUT9 and ABCG2 were associated with urate levels.
authors.affiliation: Université Paris 7, Assistance-publique-Hôpitaux de Paris, hôpital Lariboisière, UFR médicale, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France. thomas.bardin@lrb.aphp.fr
authors.forename: Thomas
authors.initials: T
authors.lastname: Bardin
authors.forename: Pascal
authors.initials: P
authors.lastname: Richette
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics; D006073:Gout / Q000453:epidemiology* / Q000235:genetics* / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics; D009765:Obesity / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D027361:Organic Anion Transporters / Q000235:genetics; D027701:Organic Cation Transport Proteins / Q000235:genetics; D012307:Risk Factors; D012737:Sex Factors
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D051246:Glucose Transport Proteins, Facilitative; D009363:Neoplasm Proteins; D027361:Organic Anion Transporters; D027701:Organic Cation Transport Proteins; C491241:SLC22A12 protein, human; C411811:SLC2A9 protein, human