title: [The bidirectional roles of macroautophagy in the regulation of heart disease].
abstract: Macroautophagy is a catabolism process and widely exists in organisms. It can degrade long-lived proteins and organelles. Numerous of evidence shows that macroautophagy is closely related with heart disease and plays bidirectional roles in its regulation. Macroautophagy can promote cell survival through the removal of damaged organelles and protein aggregates. However, excessive macroautophagy can lead to cell death when facing to serious damage. This paper reviews the research progress of macroautophagy in the regulation of heart disease, including macroautophagy formation, the relationship between macroautophagy and apoptosis, macroautophagy under the conditions of myocardial ischemia-reperfusion, hypertrophy and heart failure, in order to find a new method for the treatment.
authors.affiliation: Department of Pharmacology, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhao
authors.forename: Wei-Jin
authors.initials: WJ
authors.lastname: Zang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001343:Autophagy / Q000502:physiology*; D006332:Cardiomegaly / Q000503:physiopathology; D006331:Heart Diseases / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology