title: Ruthenium-catalyzed selective hydrogenation of bis-arylidene tetramic acids. Application to the synthesis of novel structurally diverse pyrrolidine-2,4-diones.
abstract: Catalytic hydrogenation of 3,5-bis-arylidenetetramic acids, known for their biological activity, has been developed. The chemoselective ruthenium-catalyzed reduction of the exocyclic carbon-carbon double bonds on pyrrolidine-2,4-dione ring system, containing other reducible functions, has been investigated. Depending on the substrate the yield of the hydrogenation process can reach up to 95%. The structural elucidation has been established using NMR and HRMS spectral data.
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemical Engineering, National Technical University of Athens, Zografos Campus, Athens 15773, Greece.
authors.forename: Christos S
authors.initials: CS
authors.lastname: Karaiskos
authors.forename: Dimitris
authors.initials: D
authors.lastname: Matiadis
authors.forename: John
authors.initials: J
authors.lastname: Markopoulos
authors.forename: Olga
authors.initials: O
authors.lastname: Igglessi-Markopoulou
mesh_terms: D002384:Catalysis; D006865:Hydrogenation; D011759:Pyrrolidines / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D011759:Pyrrolidines; D011760:Pyrrolidinones; C009435:tetramic acid; D012428:Ruthenium; C032519:pyrrolidine