title: Adaptive changes of pancreatic protease secretion to a short-term vegan diet: influence of reduced intake and modification of protein.
abstract: In our previous study, we demonstrated that abstaining from meat, for 1 month, by healthy omnivores (lacto-ovovegetarian model) resulted in a statistical decrease in pancreatic secretion as measured by faecal elastase-1 output. However, no correlation between relative and non-relative changes of energy and nutrient consumption and pancreatic secretion was documented. Therefore, in the present study, we aimed to assess the changes of exocrine pancreatic secretion with a more restrictive dietetic modification, by applying a vegan diet. A total of twenty-one healthy omnivores (sixteen females and five males) participated in the prospective study lasting for 6 weeks. The nutrient intake and faecal output of pancreatic enzymes (elastase-1, chymotrypsin and lipase) were assessed twice during the study. Each assessment period lasted for 7 d: the first before the transition to the vegan diet (omnivore diet) and the second during the last week of the study (vegan diet). The dietary modification resulted in a significant decrease in faecal elastase-1 (P < 0·05) and chymotrypsin output (P < 0·04). The lipase excretion remained unchanged. The decrease in proteolytic enzymes was documented to be positively correlated with a decreased protein intake (P < 0·05). In addition, elastase-1 and chymotrypsin outputs were also related to the changes of protein type, plant v. animal (P < 0·04 and P < 0·03, respectively). It was concluded that significant reduction and modification of protein intake due to a short-term vegan diet resulted in an adaptation of pancreatic protease secretion in healthy volunteers.
authors.affiliation: 1st Chair of Pediatrics, Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Walkowiak
authors.forename: Edyta
authors.initials: E
authors.lastname: Mądry
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lisowska
authors.forename: Anna
authors.initials: A
authors.lastname: Szaflarska-Popławska
authors.forename: Marian
authors.initials: M
authors.lastname: Grzymisławski
authors.forename: Hanna
authors.initials: H
authors.lastname: Stankowiak-Kulpa
authors.forename: Juliusz
authors.initials: J
authors.lastname: Przysławski
mesh_terms: D000328:Adult; D000465:Algorithms; D002918:Chymotrypsin / Q000378:metabolism; D014676:Diet, Vegetarian / Q000009:adverse effects; D004044:Dietary Proteins / Q000008:administration & dosage*; D015536:Down-Regulation; D002149:Energy Intake; D005243:Feces / Q000201:enzymology; D005260:Female; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008297:Male; D046790:Pancreas, Exocrine / Q000201:enzymology* / Q000378:metabolism*; D010196:Pancreatic Elastase / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D011446:Prospective Studies; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D004044:Dietary Proteins; D008049:Lipase; C518354:PNLIP protein, human; D010447:Peptide Hydrolases; D002918:Chymotrypsin; D010196:Pancreatic Elastase