title: [Progress of research in the improvement of the antithrombogenic property of biomedical polyurethane].
abstract: The progress of research of the physical and chemical modification methods to improve the antithrombogenic property of biomedical polyurethane (PU) in the past five years is reviewed in this paper. The physical modification method includes physical blending, physical vapor deposition (PVD) and replication molding technique. Meanwhile, chemical modification method is focused on the covalent bonding to immobilized special molecular. Moreover, the covalent bonding method covered functionalizing the PU surface with tailor-made groups in the bulk and the activation of the surface to form unstable active sites for further reactions.
authors.affiliation: Department of Materials Science, Fudan University, and Department of Neurosurgery, Huashan Hospital, Shanghai 200433, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Lian
authors.forename: Bing
authors.initials: B
authors.lastname: Leng
authors.forename: Yanbao
authors.initials: Y
authors.lastname: Fu
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Ma
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D055598:Chemical Phenomena; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D001672:Biocompatible Materials; D005343:Fibrinolytic Agents; D011140:Polyurethanes