title: Plasma 25-hydroxyvitamin d is independently associated with hemoglobin concentration in male subjects with type 2 diabetes mellitus.
abstract: Introduction. It was reported that 25-hydroxyvitamin D level was independently associated with anemia in chronic kidney diseases, but the relation between vitamin D and anemia in diabetes mellitus is not still certain. We analyzed the relation between plasma 25-hydroxyvitamin D level and hemoglobin concentration. Materials and Methods. A cross-sectional study in male patients with type 2 diabetes was performed. Correlation coefficients and standardized partial regression coefficient for the hemoglobin concentration were evaluated. Results. Hemoglobin concentration was positively correlated with body mass index, HbA1c, estimated glomerular filtration rate, cholinesterase, and 25-hydroxyvitamin D level and negatively correlated with age, duration of diabetes mellitus, serum creatinine, and urinary albumin creatinine ratio. Multiple regression analysis revealed the independent relation of 25-hydroxyvitamin D to hemoglobin concentration. Conclusions. Plasma circulating form of vitamin D is significantly associated with hemoglobin concentration in diabetes mellitus independent of the clinical markers for kidney function or nutrition.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Shu
authors.initials: S
authors.lastname: Meguro
authors.forename: Masuomi
authors.initials: M
authors.lastname: Tomita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Katsuki
authors.forename: Kiyoe
authors.initials: K
authors.lastname: Kato
authors.forename: Henpiru
authors.initials: H
authors.lastname: Oh
authors.forename: Akira
authors.initials: A
authors.lastname: Ainai
authors.forename: Ryo
authors.initials: R
authors.lastname: Ito
authors.forename: Shu
authors.initials: S
authors.lastname: Takeda
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kawai
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Atsumi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
authors.forename: Hideki
authors.initials: H
authors.lastname: Hasegawa