title: Encoding and decoding photoperiod in the mammalian pars tuberalis.
abstract: In mammals, the nocturnal melatonin signal is well established as a key hormonal indicator of seasonal changes in day-length, providing the brain with an internal representation of the external photoperiod. The pars tuberalis (PT) of the pituitary gland is the major site of expression of the G-coupled receptor MT1 in the brain and is considered as the main site of integration of the photoperiodic melatonin signal. Recent studies have revealed how the photoperiodic melatonin signal is encoded and conveyed by the PT to the brain and the pituitary, but much remains to be resolved. The development of new animal models and techniques such as cDNA arrays or high throughput sequencing has recently shed the light onto the regulatory networks that might be involved. This review considers the current understanding of the mechanisms driving photoperiodism in the mammalian PT with a particular focus on the seasonal prolactin secretion.
authors.affiliation: University of Manchester, Faculty of Life Sciences, Manchester, UK. Sandrine.dupre@manchester.ac.uk
authors.forename: Sandrine M
authors.initials: SM
authors.lastname: Dupré
mesh_terms: D006801:Humans; D008550:Melatonin / Q000096:biosynthesis / Q000502:physiology*; D017440:Photoperiod; D010903:Pituitary Gland, Anterior / Q000502:physiology*; D044122:Receptor, Melatonin, MT1 / Q000096:biosynthesis / Q000235:genetics; D012621:Seasons
chemical_list: D044122:Receptor, Melatonin, MT1; D008550:Melatonin