title: Non-psychiatric comorbidity associated with Alzheimer's disease.
abstract: The burden of medical comorbidity in individuals with Alzheimer's disease is greater than that observed in matched individuals without dementia. This has important implications for all clinicians and healthcare providers who deal with this common condition. The prevalence of vascular risk factors and vascular disease is particularly high. Additionally, associations with a number of other chronic medical conditions have been described, including thyroid disorders, sleep apnoea, osteoporosis and glaucoma. This review gives an overview of evidenced medical (non-psychiatric) comorbidity associated with Alzheimer's disease and briefly explores the underlying mechanisms that may account for these associations.
authors.affiliation: Old Age Psychiatry Directorate, Royal Cornhill Hospital, UK.
authors.forename: A
authors.initials: A
authors.lastname: Duthie
authors.forename: D
authors.initials: D
authors.lastname: Chew
authors.forename: R L
authors.initials: RL
authors.lastname: Soiza
mesh_terms: D000544:Alzheimer Disease / Q000453:epidemiology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000453:epidemiology; D002423:Cause of Death; D002908:Chronic Disease; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005901:Glaucoma / Q000453:epidemiology; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology; D007037:Hypothyroidism / Q000453:epidemiology; D008297:Male; D009369:Neoplasms / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology; D010024:Osteoporosis / Q000453:epidemiology; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000453:epidemiology; D014652:Vascular Diseases / Q000453:epidemiology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal