title: Diversity oriented design of various hydrazides and their in vitro evaluation against Mycobacterium tuberculosis H37Rv strains.
abstract: Control and prevention of tuberculosis is a major challenge, as one-third of the world's population is infected with Mycobacterium tuberculosis. The resurgence of tuberculosis and the emergence of multidrug-resistance strains of mycobacteria, necessitate the search for new class of antimycobacterial agents. As a part of investigation of new antitubercular agents in this laboratory, we describe the syntheses of various hydrazides of comarins, quinolones and pyrroles and screening against M. tuberculosis (Mtb) H37(Rv) by using rifampin as a standard drug. Among the designed molecules, the most prominent compounds 2a-g, 4a and 9a showed >90% GI at MIC<6.25 μg/mL. Finally, these studies suggests that compounds 2a-g, 4a and 9a may serve as promising lead scaffolds for further generation of new anti-TB agents.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, 37077 Göttingen, Germany.
authors.forename: Atul
authors.initials: A
authors.lastname: Manvar
authors.forename: Abhay
authors.initials: A
authors.lastname: Bavishi
authors.forename: Ashish
authors.initials: A
authors.lastname: Radadiya
authors.forename: Jignesh
authors.initials: J
authors.lastname: Patel
authors.forename: Vipul
authors.initials: V
authors.lastname: Vora
authors.forename: Narshih
authors.initials: N
authors.lastname: Dodia
authors.forename: Kena
authors.initials: K
authors.lastname: Rawal
authors.forename: Anamik
authors.initials: A
authors.lastname: Shah
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D006834:Hydrazines