title: [Reconstruction of spatial structure of plant protein phosphatase type-1 and -2A in complex with okadaic acid].
abstract: The homology modeling, based on known temple structures of Homo sapiens protein phosphatase type-1 and -2A was implemented. The spatial structures of the human protein phosphatases and their plant homologs from Arabidopsis thaliana was predicted. The quality of models was confirmed by conformational analysis and root mean square deviations. The sites of okadaic acid binding in molecules of plant protein phosphatases (type-1 and -2A) were proved by the data of comparative analysis and molecular dynamics.
authors.forename: D A
authors.initials: DA
authors.lastname: Samofalova
authors.forename: P A
authors.initials: PA
authors.lastname: Karpov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Nyporko
authors.forename: Ia B
authors.initials: IaB
authors.lastname: Blium
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000187:drug effects / Q000201:enzymology; D029681:Arabidopsis Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry*; D020134:Catalytic Domain; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D019319:Okadaic Acid / Q000737:chemistry / Q000494:pharmacology*; D011485:Protein Binding; D054645:Protein Phosphatase 1 / Q000037:antagonists & inhibitors / Q000737:chemistry*; D054648:Protein Phosphatase 2 / Q000037:antagonists & inhibitors / Q000737:chemistry*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D029681:Arabidopsis Proteins; D004791:Enzyme Inhibitors; D019319:Okadaic Acid; D054645:Protein Phosphatase 1; D054648:Protein Phosphatase 2