title: ['ASIA' - Autoimmune/inflammatory syndrome induced by adjuvants: even and odd].
abstract: Recently, Shoenfeld and Agmon-Levin described a potential new syndrome, namely ASIA - autoimmune/inflammatory syndrome induced by adjuvants, that comprises four medical conditions: siliconosis, the Gulf war syndrome, the macrophagic myofasciitis syndrome and post-vaccination phenomena, characterized by hyperactive immune responses accompanied by a similar complex of signs and symptoms. Most relevantly, these conditions share a linkage represented by adjuvants. This common soil may possibly induce autoimmune or auto-inflammatory diseases in humans as it was demonstrated in different animal models. Reconsidering under a unified umbrella this apparently detached condition is not only intriguing, but also provocative, and may help in unraveling novel pathogenetic mechanisms, preventive measures, and therapeutic targets.
authors.affiliation: Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico 155, Rome, Italy. carlo.perricone@gmail.com
authors.forename: C
authors.initials: C
authors.lastname: Perricone
authors.forename: C
authors.initials: C
authors.lastname: Alessandri
authors.forename: G
authors.initials: G
authors.lastname: Valesini
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000276:immunology; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects / Q000276:immunology; D005208:Fasciitis / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000139:chemically induced* / Q000276:immunology; D009220:Myositis / Q000139:chemically induced* / Q000276:immunology; D018923:Persian Gulf Syndrome / Q000139:chemically induced* / Q000276:immunology; D019736:Prostheses and Implants / Q000009:adverse effects; D012828:Silicones / Q000009:adverse effects*; D013577:Syndrome; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D004785:Environmental Pollutants; D012828:Silicones