title: Outcome of pregnancies complicated by oligohydramnios or anhydramnios of renal origin.
abstract: OBJECTIVE
  To evaluate the outcome of fetuses with oligohydramnios due to kidney anomalies.
  
  
  METHODS
  A retrospective study was performed of all pregnancies diagnosed with oligohydramnios and associated kidney anomalies during the period 2000-2008. Outcome included pregnancy outcome, mortality, and morbidity. Morbidity included renal function based on the glomerular filtration rate (GFR) during follow-up.
  
  
  RESULTS
  A total of 71 pregnancies were evaluated; 36 fetuses presented on ultrasound with cystic dysplasia, 15 with polycystic kidney disease (PKD) and 20 with hydronephrosis. Twenty-three (32%) had associated anomalies. In 49 fetuses (69%), the diagnosis had been made before 24 weeks of gestational age (GA); 41 of those pregnancies were terminated. Twenty-five neonates were live born: 10 survived, 15 died. Prognostic factors for survival included GA at diagnosis (32.2 weeks for survivors vs 28.1 weeks for non-survivors; P = 0.02), diagnosis of hydronephrosis (7 in the survivors vs 4 in the non-survivors: P = 0.05), isolated anomaly (9 in the survivors vs 7 in the non-survivors: P = 0.04). Severity of oligohydramnios (1 case of anhydramnios in the survivors vs 7 in the non-survivors: P = 0.08) was not significant. The 1-year GFR was below 50 mL/min.1.73 m(2) in four of the ten survivors.
  
  
  CONCLUSIONS
  The prognosis of early onset renal oligohydramnios is poor. Predictive determinants of survival are: GA at diagnosis, nature of renal anomaly (hydronephrosis vs other), and presence of associated anomalies.
authors.affiliation: Department of Prenatal Medicine, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands. e.grijseels@erasmusmc.nl
authors.forename: E W M
authors.initials: EW
authors.lastname: Grijseels
authors.forename: P T M Echteld
authors.initials: PT
authors.lastname: van-Hornstra
authors.forename: L C P
authors.initials: LC
authors.lastname: Govaerts
authors.forename: T E
authors.initials: TE
authors.lastname: Cohen-Overbeek
authors.forename: R R
authors.initials: RR
authors.lastname: de Krijger
authors.forename: B J
authors.initials: BJ
authors.lastname: Smit
authors.forename: K
authors.initials: K
authors.lastname: Cransberg
mesh_terms: D000015:Abnormalities, Multiple / Q000401:mortality / Q000473:pathology; D000025:Abortion, Eugenic; D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D006869:Hydronephrosis / Q000151:congenital / Q000175:diagnosis / Q000401:mortality; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities*; D007674:Kidney Diseases / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D009426:Netherlands / Q000453:epidemiology; D016104:Oligohydramnios / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D015996:Survival Rate; D016216:Ultrasonography, Prenatal; D055815:Young Adult