title: Cyclization reaction for the synthesis of polysubstituted naphthalenes in the presence of Au(I) precatalysts.
abstract: Au(I)-catalyzed cyclization of alkenyl carbonyl compounds leading to a variety of substituted naphthalenes has been developed. This process exploits a dual function of the Au(I) catalyst: (1) the oxophilic nature of the Au(I) catalyst, counterintuitive to the π-acidic reactivities generally associated with Au catalysts, and (2) olefin isomerization supported by the outcome of isotope scrambling experiments. It cannot be completely excluded that TfOH is a true operative catalyst in this protocol. In view of the practicality, the unnecessity of isomerically pure starting material in this reaction is particularly attractive and valuable.
authors.affiliation: Department of Chemistry and Research Institute for Natural Sciences, Hanyang University, Seoul 133-791, Korea.
authors.forename: Arun R
authors.initials: AR
authors.lastname: Jagdale
authors.forename: Jong Hyub
authors.initials: JH
authors.lastname: Park
authors.forename: So Won
authors.initials: SW
authors.lastname: Youn
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009281:Naphthalenes; D006046:Gold