title: SNARE derived peptide mimic inducing membrane fusion.
abstract: SNARE proteins mediate membrane fusion between synaptic vesicles and the plasma membrane. A minimized peptide SNARE model system with reduced complexity was introduced combining the native SNARE transmembrane (TMD) and linker domains with artificial coiled-coil forming peptides. Specific membrane fusion initiated by coiled-coil recognition was shown by lipid and content mixing vesicle assays.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Tammannstr. 2, 37077 Göttingen, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Meyenberg
authors.forename: Antonina S
authors.initials: AS
authors.lastname: Lygina
authors.forename: Geert
authors.initials: G
authors.lastname: van den Bogaart
authors.forename: Reinhard
authors.initials: R
authors.lastname: Jahn
authors.forename: Ulf
authors.initials: U
authors.lastname: Diederichsen
mesh_terms: D000595:Amino Acid Sequence; D018360:Crystallography, X-Ray; D008081:Liposomes / Q000737:chemistry; D008561:Membrane Fusion; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D050600:SNARE Proteins / Q000737:chemistry* / Q000378:metabolism; D050827:Syntaxin 1 / Q000737:chemistry / Q000378:metabolism; D050988:Vesicle-Associated Membrane Protein 2 / Q000737:chemistry / Q000378:metabolism
chemical_list: D008081:Liposomes; D010455:Peptides; D050600:SNARE Proteins; D050827:Syntaxin 1; D050988:Vesicle-Associated Membrane Protein 2