title: Body weight gain and deep brain stimulation.
abstract: Deep brain stimulation (DBS) is a neurosurgical technique that has now been available for some 25 years. It is used in the treatment of various motor disorders, e.g. Parkinson's disease (PD), essential tremor and dystonia, and neuropsychiatric illnesses, e.g. obsessive-compulsive disorder and Tourette syndrome. The surgical targets of DBS include the thalamic ventralis intermedius nucleus (Vim), the globus pallidus internus (GPi) and more recently the subthalamic nucleus (STN), currently considered as the reference target in the treatment of PD. In the last ten years, most studies in PD patients have described a rapid and marked weight gain in the months following DBS of the STN. This weight gain sometimes induces obesity and can have metabolic repercussions. The physiopathological mechanisms responsible for the weight gain are multifactorial (changes in energy metabolism and eating behaviour, reduction of motor complications, etc.). This review reports current knowledge concerning weight changes in patients treated by DBS with different surgical targets. It also describes the mechanisms responsible for weight gain and the health outcome for the patients.
authors.affiliation: CHU Clermont-Ferrand, Neurology Department, Clermont-Ferrand, F-63001, France. irieu@chu-clermontferrand.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rieu
authors.forename: Philippe
authors.initials: P
authors.lastname: Derost
authors.forename: Miguel
authors.initials: M
authors.lastname: Ulla
authors.forename: Ana
authors.initials: A
authors.lastname: Marques
authors.forename: Bérangère
authors.initials: B
authors.lastname: Debilly
authors.forename: Ingrid
authors.initials: I
authors.lastname: De Chazeron
authors.forename: Isabelle
authors.initials: I
authors.lastname: Chéreau
authors.forename: Jean Jacques
authors.initials: JJ
authors.lastname: Lemaire
authors.forename: Yves
authors.initials: Y
authors.lastname: Boirie
authors.forename: Pierre Michel
authors.initials: PM
authors.lastname: Llorca
authors.forename: Franck
authors.initials: F
authors.lastname: Durif
mesh_terms: D001835:Body Weight / Q000502:physiology*; D001921:Brain / Q000473:pathology / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods; D006801:Humans; D010300:Parkinson Disease / Q000628:therapy