title: Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination.
abstract: A serological survey for antibodies to influenza viruses was performed in China on a group of people without a history of influenza vaccination. Using the haemagglutination inhibition (HI) assay, we found seropositivity rates for seasonal H3N2 to be significantly higher than those for seasonal H1N1. Samples positive for antibodies to the pandemic (H1N1) 2009 virus increased from 0.6% pre-outbreak to 4.5% (p <0.01) at 1 year post-outbreak. Interestingly, HI and neutralization tests showed that 1.4% of people in the group have antibodies recognizing H9N2 avian influenza viruses, suggesting that infection with this subtype may be more common than previously thought.
authors.affiliation: National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Zheng
authors.forename: K
authors.initials: K
authors.lastname: Yang
authors.forename: F
authors.initials: F
authors.lastname: Zeng
authors.forename: S-Y
authors.initials: SY
authors.lastname: Lau
authors.forename: W L
authors.initials: WL
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: N
authors.initials: N
authors.lastname: Xia
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology; D009980:Influenza A virus / Q000145:classification / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D008875:Middle Aged; D058873:Pandemics; D012424:Rural Population; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral