title: Clinical and infection control implications of Clostridium difficile infection with negative enzyme immunoassay for toxin.
abstract: In a prospective study of 132 patients with a diagnosis of Clostridium difficile infection (CDI) by polymerase chain reaction, 43 (32%) had enzyme immunoassay (EIA) results negative for toxin. EIA-negative patients with CDI did not differ in clinical presentation from EIA-positive patients and presented a similar risk for transmission of spores.
authors.affiliation: Department of Infectious Diseases, University Hospitals of Cleveland, OH, USA.
authors.forename: Dubert M
authors.initials: DM
authors.lastname: Guerrero
authors.forename: Christina
authors.initials: C
authors.lastname: Chou
authors.forename: Lucy A
authors.initials: LA
authors.lastname: Jury
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Nerandzic
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Cadnum
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Donskey
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001427:Bacterial Toxins / Q000032:analysis*; D016360:Clostridioides difficile / Q000302:isolation & purification* / Q000472:pathogenicity*; D003015:Clostridium Infections / Q000175:diagnosis* / Q000473:pathology* / Q000517:prevention & control / Q000635:transmission; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D017053:Infection Control / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011446:Prospective Studies
chemical_list: D001427:Bacterial Toxins