title: Analysis of MMP2 promoter polymorphisms in childhood obesity.
abstract: BACKGROUND
  Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population.
  
  
  RESULTS
  546 samples from the Auckland Birthweight Collaborative (ABC) study were genotyped for the three MMP-2 promoter SNPs -1306 C/T (rs243865), -1575G/A (rs243866) and -790 T/G (rs243864) using the Sequenom genotyping platform. The results demonstrated that an MMP-2 promoter haplotype is associated with PBF in New Zealand 7 year old children.
  
  
  CONCLUSIONS
  We have previously determined that environmental factors are associated with differences in PBF in this study group, and now we have demonstrated a possible genetic contribution.
authors.affiliation: Discipline of Nutrition, FMHS, The University of Auckland, New Zealand. ang.morgan@auckland.ac.nz.
authors.forename: Angharad R
authors.initials: AR
authors.lastname: Morgan
authors.forename: Dug Yeo
authors.initials: DY
authors.lastname: Han
authors.forename: John Md
authors.initials: JM
authors.lastname: Thompson
authors.forename: Edwin A
authors.initials: EA
authors.lastname: Mitchell
authors.forename: Lynnette R
authors.initials: LR
authors.lastname: Ferguson