title: Phosphatases: providing safe passage through mitotic exit.
abstract: The mitosis-to-interphase transition involves dramatic cellular reorganization from a state that supports chromosome segregation to a state that complies with all functions of an interphase cell. This process, termed mitotic exit, depends on the removal of mitotic phosphorylations from a broad range of substrates. Mitotic exit regulation involves inactivation of mitotic kinases and activation of counteracting protein phosphatases. The key mitotic exit phosphatase in budding yeast, Cdc14, is now well understood. By contrast, in animal cells, it is now emerging that mitotic exit relies on distinct regulatory networks, including the protein phosphatases PP1 and PP2A.
authors.affiliation: Institute of Biochemistry, Department of Biology, Swiss Federal Institute of Technology Zürich (ETHZ), HPM D11.3, Schafmattstrasse 18, 8093 Zürich, Switzerland.
authors.forename: Claudia
authors.initials: C
authors.lastname: Wurzenberger
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Gerlich
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D064127:Aurora Kinases; D016203:CDC2 Protein Kinase / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D056744:Cyclin B1 / Q000502:physiology; D006801:Humans; D007399:Interphase / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology / Q000628:therapy; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology*; D054645:Protein Phosphatase 1 / Q000502:physiology; D054648:Protein Phosphatase 2 / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology; D000097869:Polo-Like Kinase 1
chemical_list: D064173:Anaphase-Promoting Complex-Cyclosome; D064127:Aurora Kinases; D016203:CDC2 Protein Kinase; D018797:Cell Cycle Proteins; D056744:Cyclin B1; D010744:Phosphoric Monoester Hydrolases; D054645:Protein Phosphatase 1; D054648:Protein Phosphatase 2; D017346:Protein Serine-Threonine Kinases; D017027:Protein Tyrosine Phosphatases; D011518:Proto-Oncogene Proteins; D029701:Saccharomyces cerevisiae Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D000097869:Polo-Like Kinase 1; C074860:CDC14 protein, S cerevisiae