title: Varenicline induces manic relapse in bipolar disorder.
abstract: Varenicline (Chantix) is commonly used to assist individuals with smoking cessation. This medication is known to affect mood and behavior. We report a patient with bipolar disorder who developed manic relapse after starting treatment with varenicline for tobacco dependence. Further research is necessary to establish the safety of using varenicline in individuals who have significant mental illness and want to stop smoking.
authors.affiliation: Nottingham City Primary Care Trust, Sherwood Health Centre, Elmswood Gardens, Sherwood, NG5 4AD Nottingham, UK. natashaknibbs@doctors.org.uk
authors.forename: Natasha
authors.initials: N
authors.lastname: Knibbs
authors.forename: Daniel Tai-yin
authors.initials: DT
authors.lastname: Tsoi
mesh_terms: D000328:Adult; D001552:Benzazepines / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000150:complications*; D005260:Female; D006801:Humans; D018722:Nicotinic Agonists / Q000009:adverse effects*; D011810:Quinoxalines / Q000009:adverse effects*; D012008:Recurrence; D016540:Smoking Cessation / Q000379:methods / Q000523:psychology; D014029:Tobacco Use Disorder / Q000188:drug therapy / Q000523:psychology; D000068580:Varenicline
chemical_list: D001552:Benzazepines; D018722:Nicotinic Agonists; D011810:Quinoxalines; D000068580:Varenicline