title: Associative retrieval processes in the human medial temporal lobe: hippocampal retrieval success and CA1 mismatch detection.
abstract: Hippocampal subfields CA(3) and CA(1) are hypothesized to differentially support the generation of associative predictions and the detection of associative mismatches, respectively. Using high-resolution functional MRI, we examined hippocampal subfield activation during associative retrieval and during subsequent comparisons of memory to matching or mismatching decision probes. Activity in the dentate gyrus/CA(2/3), CA(1), and other medial temporal lobe subregions tracked associative retrieval success, whereas activity in CA(1) and the perirhinal cortex tracked the presence of associative mismatches. These data support the hypothesis that CA(1) acts as a "comparator," detecting when memory for the past and sensory input in the present diverge.
authors.affiliation: Department of Psychology, Stanford University, Stanford, California 94305, USA. kanile@stanford.edu
authors.forename: Janice
authors.initials: J
authors.lastname: Chen
authors.forename: Rosanna K
authors.initials: RK
authors.lastname: Olsen
authors.forename: Alison R
authors.initials: AR
authors.lastname: Preston
authors.forename: Gary H
authors.initials: GH
authors.lastname: Glover
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wagner
mesh_terms: D001931:Brain Mapping; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008568:Memory / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*