title: Outcomes of recurrent head and neck cutaneous squamous cell carcinoma.
abstract: Recurrent, advanced stage cutaneous squamous cell carcinoma (cSCC) is uncommon with limited publications on patient outcomes. A retrospective study including patients who underwent surgical resection for recurrent, advanced stage cSCC of the head and neck was performed (n = 72). Data regarding tumor site, stage, treatment, parotid involvement, perineural invasion, positive margins, metastasis, and disease-free survival was analyzed. The majority of patients were male (85%) and presented with recurrent stage III (89%) cSCC. Two-year disease-free survival was 62% and decreased to 47% at 5 years. Parotid involvement, positive margins, nodal metastasis, or the presence of perineural invasion did not correlate with decreased survival (P > .05). Distant metastasis was a strong indicator of poor overall survival (P < .001). Adjuvant postoperative radiotherapy did not improve overall survival (P = .42). Overall survival was poor for patients with advanced recurrent cSCC despite the combined treatment with surgery and radiotherapy.
authors.affiliation: Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USA.
authors.forename: Nichole R
authors.initials: NR
authors.lastname: Dean
authors.forename: Larissa
authors.initials: L
authors.lastname: Sweeny
authors.forename: J Scott
authors.initials: JS
authors.lastname: Magnuson
authors.forename: William R
authors.initials: WR
authors.lastname: Carroll
authors.forename: Daniel
authors.initials: D
authors.lastname: Robinson
authors.forename: Renee A
authors.initials: RA
authors.lastname: Desmond
authors.forename: Eben L
authors.initials: EL
authors.lastname: Rosenthal