title: Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease.
abstract: Oxidative imbalance is one of the earliest manifestations of Alzheimer disease (AD) actually preceding the classic pathology of amyloid β deposits and neurofibrillary tangles. Clinical trials examining antioxidant modulation by a number of global interventions show efficacy, while simple supplementation has limited benefit suggesting complexity of multiple contributing factors. In this review, we highlight new insights regarding novel approaches to understanding and treating AD based on holistic views of oxidative balance including diet.
authors.affiliation: UTSA Neurosciences Institute and Department of Biology, College of Sciences, University of Texas at San Antonio, San Antonio, Texas, USA.
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Clark
authors.forename: Hyun Pil
authors.initials: HP
authors.lastname: Lee
authors.forename: Raj K
authors.initials: RK
authors.lastname: Rolston
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: Michael W
authors.initials: MW
authors.lastname: Marlatt
authors.forename: Rudy J
authors.initials: RJ
authors.lastname: Castellani
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nunomura
authors.forename: Gemma
authors.initials: G
authors.lastname: Casadesus
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: Hyoung-Gon
authors.initials: HG
authors.lastname: Lee
authors.forename: George
authors.initials: G
authors.lastname: Perry