title: Serum clearance of iodixanol for estimating glomerular filtration rate in calves.
abstract: To evaluate serum clearance of iodixanol, applicable to the estimation of glomerular filtration rate (GFR), clinically healthy and experimentally-induced nephropathy calves were prepared. Iodixanol was administered intravenously at 40 mg I/kg, and blood was withdrawn 60, 120, and 180 min later. Serum iodixanol concentration was determined by high-performance liquid chromatography. No statistical difference in GFR was noted between strains (Holstein vs. Japanese Black) or sexes, and the α(2)-adrenergic agonist xylazine increased GFR. In calves subjected to right renal vessel ligation, followed by a left nephrectomy, a marked reduction in GFR was observed with renal ischemic changes. These results suggest that the GFR estimation by serum iodixanol clearance is a ready-to-use tool in calf research and practice owing to the ease of monitoring serial renal function.
authors.affiliation: Department of Veterinary Basic Medicine, Iwate University, Morioka, Iwate 020–8550, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Imai
authors.forename: Norio
authors.initials: N
authors.lastname: Yamagishi
authors.forename: Danil
authors.initials: D
authors.lastname: Kim
authors.forename: Bhuminand
authors.initials: B
authors.lastname: Devkota
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sato
authors.forename: Isao
authors.initials: I
authors.lastname: Murayama
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Furuhama
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D002417:Cattle / Q000235:genetics / Q000502:physiology*; D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media / Q000493:pharmacokinetics*; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology*; D007668:Kidney / Q000098:blood supply; D008297:Male; D009392:Nephrectomy; D014283:Triiodobenzoic Acids / Q000097:blood / Q000493:pharmacokinetics*; D014991:Xylazine / Q000494:pharmacology
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D014991:Xylazine; D003404:Creatinine; C044834:iodixanol