title: An ecologic analysis of county-level PM2.5 concentrations and lung cancer incidence and mortality.
abstract: Few studies have explored the relationship between PM2.5 and lung cancer incidence. Although results are mixed, some studies have demonstrated a positive relationship between PM2.5 and lung cancer mortality. Using an ecologic study design, we examined the county-level associations between PM2.5 concentrations (2002-2005) and lung cancer incidence and mortality in North Carolina (2002-2006). Positive trends were observed between PM2.5 concentrations and lung cancer incidence and mortality; however, the R2 for both were <0.10. The slopes for the relationship between PM2.5 and lung cancer incidence and mortality were 1.26 (95% CI 0.31, 2.21, p-value 0.01) and 0.73 (95% CI 0.09, 1.36, p-value 0.03) per 1 μg/m3 PM2.5, respectively. These associations were slightly strengthened with the inclusion of variables representing socioeconomic status and smoking. Although variability is high, thus reflecting the importance of tobacco smoking and other etiologic agents that influence lung cancer incidence and mortality besides PM2.5, a positive trend is observed between PM2.5 and lung cancer incidence and mortality. This suggests the possibility of an association between PM2.5 concentrations and lung cancer incidence and mortality.
authors.affiliation: National Center for Environmental Assessment, U.S. Environmental Protection Agency, 109 T.W. Alexander Dr, MD B243-01, Research Triangle Park, NC 27711, USA. vinikoor-imler.lisa@epa.gov
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Vinikoor-Imler
authors.forename: J Allen
authors.initials: JA
authors.lastname: Davis
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Luben
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects / Q000032:analysis*; D004463:Ecology; D004781:Environmental Exposure / Q000032:analysis; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000401:mortality*; D008297:Male; D009657:North Carolina / Q000453:epidemiology; D010316:Particle Size; D012107:Research Design
chemical_list: D000393:Air Pollutants