title: Brain lipid binding protein (FABP7) as modulator of astrocyte function.
abstract: Over a century ago, hyperplasia and hypertrophy of astrocytes was noted as a histopathological hallmark of multiple sclerosis and was hypothesized to play an important role in the development and course of this disease. However until today, the factual contribution of astrocytes to multiple sclerosis is elusive. Astrocytes may play an active role during degeneration and demyelination by controlling local inflammation in the CNS, provoking damage of oligodendrocytes and axons, and glial scarring but might also be beneficial by creating a permissive environment for remyelination and oligodendrocyte precursor migration, proliferation, and differentiation. Recent findings from our lab suggest that brain lipid binding protein (FABP7) is implicated in the course of multiple sclerosis and the regulation of astrocyte function. The relevance of our findings and data from other groups are highlighted and discussed in this paper in the context of myelin repair.
authors.affiliation: Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany. mkipp@ukaachen.de
authors.forename: M
authors.initials: M
authors.lastname: Kipp
authors.forename: T
authors.initials: T
authors.lastname: Clarner
authors.forename: S
authors.initials: S
authors.lastname: Gingele
authors.forename: F
authors.initials: F
authors.lastname: Pott
authors.forename: S
authors.initials: S
authors.lastname: Amor
authors.forename: P
authors.initials: P
authors.lastname: van der Valk
authors.forename: C
authors.initials: C
authors.lastname: Beyer
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000473:pathology; D002352:Carrier Proteins / Q000378:metabolism*; D003471:Cuprizone; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism*; D006801:Humans; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology; D009186:Myelin Sheath / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; C107608:FABP7 protein, human; C086936:Fabp7 protein, mouse; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D009419:Nerve Tissue Proteins; D025521:Tumor Suppressor Proteins; D003471:Cuprizone