title: Association of candidate genes with phenotypic traits relevant to anorexia nervosa.
abstract: This analysis is a follow-up to an earlier investigation of 182 genes selected as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN). As those initial case-control results revealed no statistically significant differences in single nucleotide polymorphisms, herein, we investigate alternative phenotypes associated with AN. In 1762 females, using regression analyses, we examined the following: (i) lowest illness-related attained body mass index; (ii) age at menarche; (iii) drive for thinness; (iv) body dissatisfaction; (v) trait anxiety; (vi) concern over mistakes; and (vii) the anticipatory worry and pessimism versus uninhibited optimism subscale of the harm avoidance scale. After controlling for multiple comparisons, no statistically significant results emerged. Although results must be viewed in the context of limitations of statistical power, the approach illustrates a means of potentially identifying genetic variants conferring susceptibility to AN because less complex phenotypes associated with AN are more proximal to the genotype and may be influenced by fewer genes.
authors.affiliation: Johns Hopkins University School of Medicine, Division of General Internal Medicine, Baltimore, MD, USA.
authors.forename: Tammy L
authors.initials: TL
authors.lastname: Root
authors.forename: Jin P
authors.initials: JP
authors.lastname: Szatkiewicz
authors.forename: Charles R
authors.initials: CR
authors.lastname: Jonassaint
authors.forename: Laura M
authors.initials: LM
authors.lastname: Thornton
authors.forename: Andrea Poyastro
authors.initials: AP
authors.lastname: Pinheiro
authors.forename: Michael
authors.initials: M
authors.lastname: Strober
authors.forename: Cinnamon
authors.initials: C
authors.lastname: Bloss
authors.forename: Wade
authors.initials: W
authors.lastname: Berrettini
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Schork
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Bergen
authors.forename: Pierre
authors.initials: P
authors.lastname: Magistretti
authors.forename: Harry
authors.initials: H
authors.lastname: Brandt
authors.forename: Steve
authors.initials: S
authors.lastname: Crawford
authors.forename: Scott
authors.initials: S
authors.lastname: Crow
authors.forename: Manfred M
authors.initials: MM
authors.lastname: Fichter
authors.forename: David
authors.initials: D
authors.lastname: Goldman
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Halmi
authors.forename: Craig
authors.initials: C
authors.lastname: Johnson
authors.forename: Allan S
authors.initials: AS
authors.lastname: Kaplan
authors.forename: Pamela K
authors.initials: PK
authors.lastname: Keel
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Klump
authors.forename: Maria
authors.initials: M
authors.lastname: La Via
authors.forename: James E
authors.initials: JE
authors.lastname: Mitchell
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rotondo
authors.forename: Janet
authors.initials: J
authors.lastname: Treasure
authors.forename: D Blake
authors.initials: DB
authors.lastname: Woodside
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Bulik
mesh_terms: D000328:Adult; D000367:Age Factors; D000856:Anorexia Nervosa / Q000235:genetics* / Q000523:psychology*; D001007:Anxiety / Q000235:genetics / Q000523:psychology; D001828:Body Image; D015992:Body Mass Index; D004328:Drive; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008572:Menarche / Q000523:psychology; D010549:Personal Satisfaction; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult