title: Revisiting Langerhans cells in paracoccidioidomycosis: expression of CD207/langerin in human cutaneous and mucosal lesions.
abstract: Langerhans cells are identified by the expression of langerin. We detected this molecule in cutaneous and mucosal lesions in paracoccidioidomycosis, an important infection in Latin America. Langerin+ cells were scarcely distributed, with short dendrites in epidermis and epithelium and were frequent in the dermis and corium, in the inflammatory infiltrate and granulomas. Mucosal lesions presented a higher expression of langerin in lesions with loose granulomas. For the first time we presented the expression of langerin in paracoccidioidomycosis. Positive cells in dermis and corium could represent migrating Langerhans cells or a new subset of langerin+ cells with a role in paracoccidioidomycosis.
authors.affiliation: Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Brazil. cpagliari@usp.br
authors.forename: Carla
authors.initials: C
authors.lastname: Pagliari
authors.forename: Elaine Raniero
authors.initials: ER
authors.lastname: Fernandes
authors.forename: Wellington Luiz
authors.initials: WL
authors.lastname: Ferreira da Silva
authors.forename: Aline
authors.initials: A
authors.lastname: Alves de Lima Silva
authors.forename: Felipe Weisshaupt
authors.initials: FW
authors.lastname: Stegun
authors.forename: Maria Irma Seixas
authors.initials: MI
authors.lastname: Duarte
authors.forename: Mirian Nacagami
authors.initials: MN
authors.lastname: Sotto
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D001706:Biopsy; D002465:Cell Movement / Q000276:immunology; D003712:Dendrites; D020405:Dermis / Q000276:immunology / Q000473:pathology; D004817:Epidermis / Q000276:immunology / Q000473:pathology; D006099:Granuloma / Q000276:immunology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D007801:Langerhans Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D007843:Latin America; D037181:Lectins, C-Type / Q000378:metabolism*; D037241:Mannose-Binding Lectins / Q000378:metabolism*; D051379:Mice; D009092:Mucous Membrane / Q000276:immunology / Q000473:pathology; D010228:Paracoccidioides / Q000502:physiology; D010229:Paracoccidioidomycosis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D011817:Rabbits; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology
chemical_list: D015703:Antigens, CD; C121916:CD207 protein, human; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins