title: A comparative validation of the abbreviated Apathy Evaluation Scale (AES-10) with the Neuropsychiatric Inventory apathy subscale against diagnostic criteria of apathy.
abstract: OBJECTIVE
  To compare the Neuropsychiatric Inventory apathy subscale (NPIa) with the abbreviated Apathy Evaluation Scale (AES-10) on discriminant validity and on their performance to distinguish residents as apathetic or nonapathetic.
  
  
  METHODS
  Cross-sectional design.
  
  
  METHODS
  Nursing home.
  
  
  METHODS
  100 residents of 4 dementia special care units (n = 58) and 3 somatic units (n = 42).
  
  
  METHODS
  Primary professional caregivers were interviewed to score the AES-10 and NPIa. The elderly care physician and the psychologist of each unit examined residents for clinical apathy using diagnostic criteria.
  
  
  RESULTS
  The AES-10 and NPIa correlated moderately with each other (r(s) = 0.62, P < .0001). The AES-10 correlated weakly (r(s) = 0.27, P = .024) and the NPIa moderately (r(s) = 0.46, P = .001) with the Cornell Scale for Depression in Dementia. Receiver operating characteristic analysis showed an area under the curve (AUC) of 0.72 (P < .01) for AES-10 and 0.67 (P < .05) for NPIa. The AES-10 produced higher sums of sensitivity and negative predictive value than the NPIa. Explorative analyses revealed that both instruments produced higher scores in dementia independently of having an apathy diagnosis, whereas AUCs were significant in nondementia (AES-10: AUC = 0.88, P < .001; NPIa: AUC = 0.77, P = .023), but not in dementia.
  
  
  CONCLUSIONS
  Both the AES-10 and NPIa may be used to distinguish apathetic from nonapathetic residents in a heterogeneous sample with and without dementia, or in residents without dementia. The AES-10 may be preferable to the NPIa apathy subscale when ruling out or screening for apathy. The performance of the scales against diagnostic criteria of apathy in dementia need to be further examined.
authors.affiliation: Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Nijmegen Medical Centre, The Netherlands. R.Leontjevas@elg.umcn.nl
authors.forename: Ruslan
authors.initials: R
authors.lastname: Leontjevas
authors.forename: Alexandra
authors.initials: A
authors.lastname: Evers-Stephan
authors.forename: Martin
authors.initials: M
authors.lastname: Smalbrugge
authors.forename: Anne Margriet
authors.initials: AM
authors.lastname: Pot
authors.forename: Viviane
authors.initials: V
authors.lastname: Thewissen
authors.forename: Debby L
authors.initials: DL
authors.lastname: Gerritsen
authors.forename: Raymond T C M
authors.initials: RT
authors.lastname: Koopmans
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D057565:Apathy; D003430:Cross-Sectional Studies; D003704:Dementia; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000592:standards*; D009735:Nursing Homes; D011569:Psychiatric Status Rating Scales / Q000592:standards*; D011594:Psychometrics; D012372:ROC Curve