title: In vitro antiplasmodial activity of crude extracts from Togolese medicinal plants.
abstract: OBJECTIVE
  To investigate the antimalarial effect of a few plants in Togo folk medicine.
  
  
  METHODS
  After ethnobotanical survey, Opilia celtidifolia, Pavetta corymbosa (P. corymbosa) and Tamarindus indica (T. indica) were selected for screening. In vitro antimalarial tests were performed on crude extracts against fresh clinical isolates of Plasmodium falciparum using the semi microtest.
  
  
  RESULTS
  Different IC(50) values of the extracts ranged from 2.042 to 100.000 μg/mL. According to the results, the methanol extract of aerial part of P. corymbosa followed by aqueous extract of fruit of T. indica were the most active (IC(50) of 2.042 and 4.786 μg/mL, respectively). Qualitative test revealed the presence of alkaloids in the leaves of P. corymbosa that may be responsible for the activity of the plant.
  
  
  CONCLUSIONS
  Our study provides scientific evidence for usage of plant in the folk medicine, and further studies are needed for identification and purification of the active principles.
authors.affiliation: Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), Université de Lomé, Togo.
authors.forename: Koffi
authors.initials: K
authors.lastname: Koudouvo
authors.forename: Simplice D
authors.initials: SD
authors.lastname: Karou
authors.forename: Denise P
authors.initials: DP
authors.lastname: Ilboudo
authors.forename: Kouami
authors.initials: K
authors.lastname: Kokou
authors.forename: Kodjo
authors.initials: K
authors.lastname: Essien
authors.forename: Kodjo
authors.initials: K
authors.lastname: Aklikokou
authors.forename: Comlan
authors.initials: C
authors.lastname: de Souza
authors.forename: Jacques
authors.initials: J
authors.lastname: Simpore
authors.forename: Mensavi
authors.initials: M
authors.lastname: Gbéassor
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D045424:Complex Mixtures / Q000302:isolation & purification / Q000494:pharmacology*; D029624:Ferns / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000469:parasitology; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D014037:Togo
chemical_list: D000962:Antimalarials; D045424:Complex Mixtures; D010936:Plant Extracts