title: Centchroman: is unsupervised long-term use warranted? Case report.
abstract: OBJECTIVE
  Centchroman (Ormeloxifene) is a synthetic non-steroidal compound used as an oral and a post-coital contraceptive. It is currently under trial for treatment of breast cancer and postmenopausal osteoporosis. Centchroman has been reported to induce only minimal side effects and no hormonal imbalance.
  
  
  METHODS
  A young woman who used centchroman for a long time in an unsupervised fashion presented with menorrhagia, which was controlled with norethisterone. Her massively enlarged uterus showed extensive decidual changes in a hyperplastic endometrium, and diffuse microglandular cervical hyperplasia.
  
  
  CONCLUSIONS
  The case suggests a prominent oestrogenic effect of centchroman on the uterus. This could be a significant adverse effect related to prolonged therapy. Lengthy intake of centchroman requires medical surveillance and long-term studies are needed.
authors.affiliation: Department of Pathology, University College of Medical Sciences, Delhi, India. drkiranpreetmalhotra@yahoo.co.in
authors.forename: Kiran Preet
authors.initials: KP
authors.lastname: Malhotra
authors.forename: Mingma
authors.initials: M
authors.lastname: Sherpa
authors.forename: Arati
authors.initials: A
authors.lastname: Bhatia
mesh_terms: D000328:Adult; D002486:Centchroman / Q000008:administration & dosage / Q000009:adverse effects*; D003283:Contraceptives, Postcoital, Synthetic / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000139:chemically induced / Q000175:diagnosis*
chemical_list: D003283:Contraceptives, Postcoital, Synthetic; D004965:Estrogen Antagonists; D002486:Centchroman