title: Benefits of a silica-based fluoride toothpaste containing o-cymen-5-ol, zinc chloride and sodium fluoride.
abstract: Fluoride toothpastes in conjunction with tooth brushing are used to clean teeth, control plaque build-up and for anti-caries benefits. Toothpastes are designed with attractive flavours and appearances to encourage regular prolonged use to maximise these benefits. The incorporation of additional ingredients into toothpaste is a convenient way to provide supplementary protection that fits into people's everyday oral care routine. Such ingredients should not compromise the primary health benefits of toothpaste nor discourage its use. o-Cymen-5-ol and zinc chloride have been incorporated into a sodium fluoride (NaF)/silica toothpaste at 0.1%w/w and 0.6%w/w respectively to provide additional benefits. These include improved gingival health maintenance, in terms of the reduction of plaque, gingival index and bleeding, and an immediate and long lasting reduction in volatile sulfur compounds (VSCs) measured on breath. These benefits can be attributed to the antimicrobial and neutralisation actions of the toothpaste. The use of established fluoride models demonstrated no compromise in NaF bioavailability. The toothpaste was formulated without compromising product aesthetics. The combination of o-cymen-5-ol and zinc chloride in toothpaste gave superior maintenance of gingival health and reduction in malodour related VSCs without compromising the primary health benefits of the toothpaste or diminishing attributes preferred for the product's use.
authors.affiliation: GlaxoSmithKline Consumer Healthcare, Weybridge, Surrey, UK. craig.s.newby@gsk.com
authors.forename: Craig S
authors.initials: CS
authors.lastname: Newby
authors.forename: Joanna L
authors.initials: JL
authors.lastname: Rowland
authors.forename: Richard J M
authors.initials: RJ
authors.lastname: Lynch
authors.forename: David J
authors.initials: DJ
authors.lastname: Bradshaw
authors.forename: Darren
authors.initials: D
authors.lastname: Whitworth
authors.forename: Mary Lynn
authors.initials: ML
authors.lastname: Bosma
mesh_terms: D002327:Cariostatic Agents / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D002712:Chlorides / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control; D005891:Gingivitis / Q000517:prevention & control*; D006209:Halitosis / Q000517:prevention & control*; D006801:Humans; D010636:Phenols / Q000627:therapeutic use*; D012822:Silicon Dioxide; D012969:Sodium Fluoride / Q000627:therapeutic use; D017001:Tooth Demineralization / Q000517:prevention & control; D014089:Tooth Remineralization; D014100:Toothpastes / Q000737:chemistry* / Q000627:therapeutic use; D017967:Zinc Compounds / Q000627:therapeutic use*
chemical_list: D002327:Cariostatic Agents; D002712:Chlorides; D010636:Phenols; D014100:Toothpastes; D017967:Zinc Compounds; D012822:Silicon Dioxide; C016837:zinc chloride; D012969:Sodium Fluoride; C512394:o-cymen-5-ol