title: Highly effective asymmetric hydrogenation of cyclic N-alkyl imines with chiral cationic Ru-MsDPEN catalysts.
abstract: A range of cyclic N-alkyl imines were efficiently hydrogenated by using a chiral cationic Ru(η(6)-cymene)(MsDPEN)(BArF) complex (MsDPEN = N-(methanesulfonyl)-1,2-diphenylethylenediamine) in high yields and up to 98% ee. A one-pot synthesis of chiral 2-phenylpyrrolidine via reductive amination was also developed.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry and Graduate School, Chinese Academy of Sciences (CAS), Beijing 100190, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Ziyuan
authors.initials: Z
authors.lastname: Ding
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.forename: Tianli
authors.initials: T
authors.lastname: Wang
authors.forename: Yanmei
authors.initials: Y
authors.lastname: He
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Fan
mesh_terms: D000586:Amination; D002384:Catalysis; D002412:Cations / Q000737:chemistry; D003500:Cyclization; D005029:Ethylenediamines / Q000737:chemistry*; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002412:Cations; D005029:Ethylenediamines; D007097:Imines; C562284:N-(methanesulfonyl)-1,2-diphenylethylenediamine; D012428:Ruthenium