title: [Efficacy and safety of oral chemo-endocrine therapy for elderly patients with breast cancer].
abstract: We often encounter elderly patients who are difficult to treat with standard treatment (e. g. anthracycline, taxane or operation) because of complication, age and so on, though there are no standard treatments for such elderly patients. We analyzed retrospectively the efficacy and safety of oral chemo-endocrine therapy for patients more than 65 years old who were difficult to treat with standard chemotherapy or operation because of complications and other reasons. Seventeen patients were analyzed. The response rate (RR) was 76.5%, and the clinical benefit rate (CBR) was 94.1%. The two-year survival rate from the start of treatment was 91.7%, and the median progression free survival (PFS) was 1, 230 days. Grade 1 anorexia and grade 1 Hand-Foot Syndrome were observed in only one patient, and it was remarkable that patients could continue to receive treatment for such a long time. In conclusion, oral chemo-endocrine therapy is effective for elderly patients difficult to treat with standard treatment, because it has better anti-tumor effect and tolerability.
authors.affiliation: Dept. of Surgery 2, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Nishizawa
authors.forename: Takako
authors.initials: T
authors.lastname: Kamio
authors.forename: Kei
authors.initials: K
authors.lastname: Aoyama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohchi
authors.forename: Shingo
authors.initials: S
authors.lastname: Kameoka
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D004703:Endocrine System / Q000187:drug effects*; D004967:Estrogens / Q000378:metabolism; D006801:Humans; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
chemical_list: D047072:Aromatase Inhibitors; D004967:Estrogens