title: Stromal differences in odontogenic cysts of a common histopathogenesis but with different biological behavior: a study with picrosirius red and polarizing microscopy.
abstract: OBJECTIVE
  The present study was undertaken to detect and compare the pattern of collagen fibers in odontogenic cysts and also to find out if this methodology could be used to predict the aggressive nature of odontogenic cysts by comparing with the odontogenic tumors.
  
  
  METHODS
  The collagen in the wall of 11 odontogenic keratocysts, 14 dentigerous cysts and 14 radicular cysts was studied histochemically by staining sections with picrosirius red and examining under polarizing microscope. This was compared to 10 cases of odontogenic tumors using Z test of proportion at 1% and 5%.
  
  
  RESULTS
  In dentigerous cysts, odontogenic keratocysts and odontogenic tumors, the predominant color of collagen fibers birefringence was found to be orangish red, whereas in radicular cysts the collagen fiber was of green color.
  
  
  CONCLUSIONS
  Similar birefringence pattern of collagen fibers between dentigerous cysts, odontogenic keratocysts and odontogenic tumors may indicate that these lesions have a common histogenesis with a broad spectrum of biological behavior and belong to the same group, i.e., are developmental in origin. Different patterns of radicular cysts suggest different biological behavior and a positive role of inflammation on polarization color of collagen fibers.
authors.affiliation: Department of Oral Pathology and Microbiology, Subharti Dental College, Meerut, India. drpooja_path@yahoo.co.in
authors.forename: P
authors.initials: P
authors.lastname: Aggarwal
authors.forename: S
authors.initials: S
authors.lastname: Saxena
mesh_terms: D000564:Ameloblastoma / Q000473:pathology*; D001391:Azo Compounds; D003094:Collagen / Q000378:metabolism; D004396:Coloring Agents; D003803:Dentigerous Cyst / Q000473:pathology*; D006801:Humans; D008859:Microscopy, Polarization; D009807:Odontogenic Cysts / Q000473:pathology*; D009808:Odontogenic Tumors / Q000473:pathology*; D011379:Prognosis; D011842:Radicular Cyst / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology*
chemical_list: D001391:Azo Compounds; D004396:Coloring Agents; C009798:C.I. direct red 80; D003094:Collagen