title: Leucine nutrition in animals and humans: mTOR signaling and beyond.
abstract: Macronutrients, such as protein or amino acid, not only supply calories but some components may also play as signaling molecules to affect feeding behavior, energy balance, and fuel efficiency. Leucine, a branched-chain amino acid is a good example. After structural roles are satisfied, the ability of leucine to function as signal and oxidative substrate is based on a sufficient intracellular concentration. Therefore, leucine level must be sufficiently high to play the signaling and metabolic roles. Leucine is not only a substrate for protein synthesis of skeletal muscle, but also plays more roles beyond that. Leucine activates signaling factor of mammalian target of rapamycin (mTOR) to promote protein synthesis in skeletal muscle and in adipose tissue. It is also a major regulator of the mTOR sensitive response of food intake to high protein diet. Meanwhile, leucine regulates blood glucose level by promoting gluconeogenesis and aids in the retention of lean mass in a hypocaloric state. It is beneficial to animal nutrition and clinical application and extrapolation to humans.
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan, China.
authors.forename: Fengna
authors.initials: F
authors.lastname: Li
authors.forename: Yulong
authors.initials: Y
authors.lastname: Yin
authors.forename: Bie
authors.initials: B
authors.lastname: Tan
authors.forename: Xiangfeng
authors.initials: X
authors.lastname: Kong
authors.forename: Guoyao
authors.initials: G
authors.lastname: Wu
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D006801:Humans; D007930:Leucine / Q000378:metabolism*; D009747:Nutritional Physiological Phenomena; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D058570:TOR Serine-Threonine Kinases; D007930:Leucine