title: Increased severity of gentamicin nephrotoxicity in aging rats is mediated by a reduced glomerular nitric oxide production.
abstract: The present experiments have been performed to assess whether the increased severity of gentamicin-induced nephrotoxicity in old animals could be mediated by a decreased production of nitric oxide. Aging rats (12 months) treated with gentamicin showed higher plasma creatinine and a higher reduction in creatinine clearance. After gentamicin treatment, glomerular nitrite production was higher in young than in old animals, whereas no differences in cortical gentamicin concentration were observed between young and aging animals. The increased severity of gentamicin-induced acute renal failure in old animals could be based on a decreased glomerular NO production after gentamicin treatment.
authors.affiliation: Instituto Reina Sofia de Investigación Nefrológica, Departamento de Fisiología y Farmacología, Universidad de Salamanca, Salamanca, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Valdivielso
authors.forename: M
authors.initials: M
authors.lastname: Reverte
authors.forename: L
authors.initials: L
authors.lastname: Rivas-Cabañero
authors.forename: J
authors.initials: J
authors.lastname: López-Novoa