title: [Efficacy of oxycodone against anti-cancer agent-induced pain in breast cancer patients during adjuvant treatment before and after surgery].
abstract: Chemotherapeutic agents, especially paclitaxel, and endocrinotherapeutic agents such as aromatase inhibitors and antiestrogen, can induce seriously painful symptoms in breast cancer patients during adjuvant treatment before and after surgery. We report five clinical cases in which oxycodone was effective against pain induced by anti-cancer agents during adjuvant treatment. Paclitaxel was used as the anti-cancer agent in each of the five patients. Aromatase inhibitors and anti-estrogen were administered to one and three patients, respectively. The daily dose of controlled-release oxycodone ranged from 10 mg to 270 mg, but none of the patients dropped out due to adverse events caused by oxycodone. Pain intensity measured by NRS decreased to less than 3 out of 10, compared to the baseline in every patient except for one. Oxycodone may be effective against anti-cancer agent-induced pain. In addition, appropriate assessment and management of pain may be crucial for breast cancer patients during adjuvant treatment.
authors.affiliation: Division of Breast Oncology, Saitama Cancer Center, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Inoue
authors.forename: Shigenari
authors.initials: S
authors.lastname: Nagai
authors.forename: Shihori
authors.initials: S
authors.lastname: Kaneko
authors.forename: Sayaka
authors.initials: S
authors.lastname: Uchida
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Toru
authors.initials: T
authors.lastname: Higuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takei
authors.forename: Toshio
authors.initials: T
authors.lastname: Tabei
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000627:therapeutic use; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D010098:Oxycodone / Q000627:therapeutic use*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement
chemical_list: D000277:Adjuvants, Pharmaceutic; D000970:Antineoplastic Agents; D010098:Oxycodone