title: PDGF: the nuts and bolts of signalling toolbox.
abstract: PDGF is a growth factor and is extensively involved in multi-dimensional cellular dynamics. It switches on a plethora of molecules other than its classical pathway. It is engaged in various transitions of development; however, if the unleashed potentials lead astray, it brings forth tumourigenesis. Conventionally, it has been assumed that the components of this signalling pathway show fidelity and act with a high degree of autonomy. However, as illustrated by the PDGF signal transduction, reinterpretation of recent data suggests that machinery is often shared between multiple pathways, and other components crosstalk to each other through multiple mechanisms. It is important to note that metastatic cascade is an intricate process that we have only begun to understand in recent years. Many of the early steps of this PDGF cascade are not readily targetable in the clinic. In this review, we will unravel the paradoxes with reference to mitrons and cellular plasticity and discuss how disruption of signalling cascade triggers cellular proliferation phase transition and metastasis. We will also focus on the therapeutic interventions to counteract resultant molecular disorders.
authors.affiliation: Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, 1 km defence road, Lahore, Pakistan. ammadahmad638@yahoo.com
authors.forename: Ammad Ahmad
authors.initials: AA
authors.lastname: Farooqi
authors.forename: Salman
authors.initials: S
authors.lastname: Waseem
authors.forename: Asma M
authors.initials: AM
authors.lastname: Riaz
authors.forename: Bilal Ahmed
authors.initials: BA
authors.lastname: Dilawar
authors.forename: Shahzeray
authors.initials: S
authors.lastname: Mukhtar
authors.forename: Sehrish
authors.initials: S
authors.lastname: Minhaj
authors.forename: Makhdoom Saad
authors.initials: MS
authors.lastname: Waseem
authors.forename: Suneel
authors.initials: S
authors.lastname: Daniel
authors.forename: Beenish Ali
authors.initials: BA
authors.lastname: Malik
authors.forename: Ali
authors.initials: A
authors.lastname: Nawaz
authors.forename: Shahzad
authors.initials: S
authors.lastname: Bhatti
mesh_terms: D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D010766:Phosphorylation; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D011485:Protein Binding; D020033:Protein Isoforms / Q000378:metabolism; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism*; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D010982:Platelet-Derived Growth Factor; D020033:Protein Isoforms; D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta