title: Alterations of drug metabolism in critically ill animals.
abstract: Critically ill animals are by nature a diverse group with multiple presenting complaints and differing levels of organ function. Pharmacokinetics and pharmacodynamics of administered compounds are affected both by the disease processes and by the interventions of the treating veterinarian. Polypharmacy is not an exception but a rule within this caseload. Basic principles of pharmacology allow for safe and effective administration of pharmaceuticals, especially in the critically ill. Future research evaluating the pharmacokinetics and pharmacodynamics of drugs important in the management of critically ill animals is imperative, and will allow evidence-based dose modification.
authors.affiliation: Department of Clinical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA. Eileen.Hackett@colostate.edu
authors.forename: Eileen S
authors.initials: ES
authors.lastname: Hackett
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Gustafson
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D002371:Cat Diseases / Q000188:drug therapy / Q000378:metabolism*; D002415:Cats; D016638:Critical Illness / Q000628:therapy*; D004066:Digestive System Diseases / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000378:metabolism*; D004285:Dogs; D007674:Kidney Diseases / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D008657:Metabolic Clearance Rate; D004364:Pharmaceutical Preparations; D019338:Polypharmacy; D013045:Species Specificity
chemical_list: D004364:Pharmaceutical Preparations