title: The Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy (REGENERATE-DCM) trial: study design.
abstract: The field of autologous stem/progenitor cell therapy for cardiovascular diseases has moved rapidly from bench to bedside. In particular, a small number of pilot studies have demonstrated the safety and efficacy of this treatment in dilated cardiomyopathy (DCM), but this has to be validated in large randomized trials. Here we introduce the Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy (REGENERATE-DCM) trial, which to our knowledge, is the first randomized, double-blind, placebo-controlled trial worldwide to investigate the role of granulocyte-colony stimulating factor and autologous bone marrow-derived stem/progenitor cells to improve cardiac function in patients with DCM.
authors.affiliation: Department of Cardiology, London Chest Hospital, Queen Mary University of London, Bonner Road, E2 9JX, London, UK.
authors.forename: Samer
authors.initials: S
authors.lastname: Arnous
authors.forename: Abdul
authors.initials: A
authors.lastname: Mozid
authors.forename: Anthony
authors.initials: A
authors.lastname: Mathur
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology*; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002311:Cardiomyopathy, Dilated / Q000628:therapy*; D002986:Clinical Trials as Topic / Q000379:methods; D023381:Endpoint Determination; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D010919:Placebos; D011994:Recombinant Proteins; D033581:Stem Cell Transplantation; D020858:Tissue and Organ Harvesting
chemical_list: D010919:Placebos; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor