title: Hapten-induced hypersensitivity reactions in the airways: atopic versus non-atopic.
abstract: Hypersensitivity reactions induced by low molecular weight compounds are investigated extensively in the skin. However, these reactions can also occur in the lungs of previously sensitized individuals after local airway challenge. This hapten-induced pulmonary hypersensitivity reaction resembles features observed in asthmatic patients, such as bronchial hyperreactivity, accumulation of inflammatory cells, and airway edema. We review data that hapten-induced hypersensitivity reactions in mouse airways can be models for both atopic and non-atopic asthma associated with low molecular weight compounds.
authors.affiliation: Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
authors.forename: Anneke H
authors.initials: AH
authors.lastname: van Houwelingen
authors.forename: Aletta D
authors.initials: AD
authors.lastname: Kraneveld
authors.forename: Frans P
authors.initials: FP
authors.lastname: Nijkamp