title: Design, synthesis and structure of novel para-quinones and their antibacterial activity.
abstract: Eight new para-quinones and one known analogue have been synthesized from p-chloranil. Five have been structurally characterized by single crystal diffraction, and a range of ligand folding is observed. All nine have been tested for their potency towards Gram(+) S. aureus and Gram(-) E. coli. Quinones 3, 6, 7 and 8 have shown activity towards S. aureus and quinones 3 and 8 also show good activity towards E. coli.
authors.affiliation: Centre for Synthesis and Chemical Biology (CSCB), School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Komala
authors.initials: K
authors.lastname: Pandurangan
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Murnaghan
authors.forename: Aurora
authors.initials: A
authors.lastname: Walshe
authors.forename: Helge
authors.initials: H
authors.lastname: Müller-Bunz
authors.forename: Francesca
authors.initials: F
authors.lastname: Paradisi
authors.forename: Grace G
authors.initials: GG
authors.lastname: Morgan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D015195:Drug Design; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D008968:Molecular Conformation; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D011809:Quinones