title: [Association between risk factors of cardiovascular diseases and osteoporosis in postmenopausal Chinese women].
abstract: OBJECTIVE
  To assess the relationship between cardiovascular risk factors and osteoporosis.
  
  
  METHODS
  2202 women aged 50 - 73 years were included in this cross-sectional study from the communities in Guangzhou, from July 2008 to January 2010. Cardiovascular risk factors including age, years since menopause, physical activity, anthropometrics, body composition, blood pressure, fasting serum lipids, glucose and uric acid, intima-media thickness (IMT) of carotid artery were assessed. Ultrasonic bone density (speed of sound) at the radius and tibia were determined. Osteoporosis was defined as T-score ≤ -2.5. Common factors for the cardiovascular risk factors were extracted using the factor analysis method.
  
  
  RESULTS
  Eight common factors representing obesity, lean mass, blood triglycerides and uric acid, cholesterol, age, blood pressure, IMT and physical activity were extracted. Data from the Multivariate logistic regression showed a dose-dependent association of greater scores of age and IMT factors and lower score of lean mass factor with the increased risk of osteoporosis at the radius and tibia. As compared with the bottom quartile, the OR (95%CI) of radius and tibia osteoporosis were 0.62 (0.44 - 0.88) and 0.62 (0.48 - 0.80) for lean mass factor, 4.02 (2.72 - 5.94) and 3.68 (2.81 - 4.82) for age factor, 1.41 (1.00 - 2.00) and 1.54 (1.19 - 2.00) for IMT factors, respectively. Moreover, greater blood pressure score was associated with higher risk of radius osteoporosis while the higher obese score, was correlated with the increased risk of tibia osteoporosis.
  
  
  CONCLUSIONS
  The cardiovascular-related risk factors of greater IMT, obesity, blood pressure and lower lean mass scores were associated with increased osteoporosis risks while called for more concern among the Chinese women.
authors.affiliation: School of Public Health, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Wen-qiong
authors.initials: WQ
authors.lastname: Xue
authors.forename: Juan
authors.initials: J
authors.lastname: Deng
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Li-ping
authors.initials: LP
authors.lastname: He
authors.forename: Zong-qiu
authors.initials: ZQ
authors.lastname: Chen
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Chen
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology*; D012307:Risk Factors