title: Label free DNA detection using large area graphene based field effect transistor biosensors.
abstract: We describe the fabrication of highly sensitive graphene based field effect transistor (FET) biosensors with a cost-effective approach and their application in label-free Deoxyribonucleic acid (DNA) detection. Chemical vapor deposition (CVD) grown graphene layers were used to achieve mass production of FET devices via conventional photolithographic patterning. Non-covalent functionalization of the graphene layer with 1-Pyrenebutanoic acid succinimidyl ester ensures high conductivity and sensitivity of the FET device. The present device could reach a detection limit as low as 3 x 10(-9) M.
authors.affiliation: Department of Chemistry, University of California, 92521 Riverside, USA.
authors.forename: Shi-Rui
authors.initials: SR
authors.lastname: Guo
authors.forename: Jian
authors.initials: J
authors.lastname: Lin
authors.forename: Miroslav
authors.initials: M
authors.lastname: Penchev
authors.forename: Emre
authors.initials: E
authors.lastname: Yengel
authors.forename: Maziar
authors.initials: M
authors.lastname: Ghazinejad
authors.forename: Cengiz S
authors.initials: CS
authors.lastname: Ozkan
authors.forename: Mihrimah
authors.initials: M
authors.lastname: Ozkan
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis*; D006108:Graphite / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D036103:Nanotechnology; D055668:Photochemical Processes
chemical_list: D006108:Graphite; D004247:DNA