title: Role of endorectal magnetic resonance spectroscopic imaging in two different Gleason scores in prostate cancer.
abstract: OBJECTIVE
  The major goal of the work was to record three-dimensional magnetic resonance spectroscopic imaging (MRSI) and to compare metabolite ratios between different Gleason scores (GS).
  
  
  METHODS
  MRSI localized by endorectal coil-acquired point-resolved spectroscopy was performed in 14 men with prostate cancer of GS 6 (n = 7) and 7 (n = 7) using a 1.5-tesla MRI scanner.
  
  
  RESULTS
  The ratio of (choline + creatine)/citrate was increased with an increase of GS, i.e. 0.590 ± 0.171 in the target lesion and 0.321 ± 0.157 in the contralateral region of patients with a GS of 6 as opposed to 1.082 ± 0.432 in the target lesion and 0.360 ± 0.243 in the contralateral region of patients with a GS of 7.
  
  
  CONCLUSIONS
  Our pilot results demonstrated that MRSI was an additional biochemical tool which is complementary to the current imaging modalities for early diagnosis and therapeutic management of prostate cancer.
authors.affiliation: Department of Radiological Sciences, University of California, Los Angeles, CA 90095-1721, USA.
authors.forename: Rajakumar
authors.initials: R
authors.lastname: Nagarajan
authors.forename: Daniel
authors.initials: D
authors.lastname: Margolis
authors.forename: Tim
authors.initials: T
authors.lastname: McClure
authors.forename: Steve
authors.initials: S
authors.lastname: Raman
authors.forename: M Albert
authors.initials: MA
authors.lastname: Thomas
mesh_terms: D000368:Aged; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading / Q000295:instrumentation; D010865:Pilot Projects; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012007:Rectum / Q000473:pathology*