title: An overview on the field of micro- and nanotechnologies for synthetic Peptide-based vaccines.
abstract: The development of synthetic peptide-based vaccines has many advantages in comparison with vaccines based on live attenuated organisms, inactivated or killed organism, or toxins. Peptide-based vaccines cannot revert to a virulent form, allow a better conservation, and are produced more easily and safely. However, they generate a weaker immune response than other vaccines, and the inclusion of adjuvants and/or the use of vaccine delivery systems is almost always needed. Among vaccine delivery systems, micro- and nanoparticulated ones are attractive, because their particulate nature can increase cross-presentation of the peptide. In addition, they can be passively or actively targeted to antigen presenting cells. Furthermore, particulate adjuvants are able to directly activate innate immune system in vivo. Here, we summarize micro- and nanoparticulated vaccine delivery systems used in the field of synthetic peptide-based vaccines as well as strategies to increase their immunogenicity.
authors.affiliation: NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country, 01006 Vitoria, Spain.
authors.forename: Aiala
authors.initials: A
authors.lastname: Salvador
authors.forename: Manoli
authors.initials: M
authors.lastname: Igartua
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Hernández
authors.forename: José Luis
authors.initials: JL
authors.lastname: Pedraz