title: Cytotoxic gold(I)-bearing dendrimers from alkyne precursors.
abstract: A series of four dendrimers end-functionalized with gold(I) has been prepared from alkyne-terminated precursors and (tricyclohexylphosphine)gold(I) azide. Isolated yields range from 84-89%, based on gold. The first-generation dendrimer is cytotoxic toward 3T3 mouse fibroblast cells. Apoptosis ensues within 6 h of treatment with gold(I).
authors.affiliation: Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Robilotto
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Alt
authors.forename: Horst A
authors.initials: HA
authors.lastname: von Recum
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Gray
mesh_terms: D016475:3T3 Cells; D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001386:Azides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D050607:Organogold Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000480:Alkynes; D001386:Azides; D003603:Cytotoxins; D050091:Dendrimers; D050607:Organogold Compounds; D010720:Phosphines