title: Endocrine and testicular changes induced by olanzapine in adult Wistar rats.
abstract: Olanzapine is an atypical antipsychotic drug that has been increasingly used in acute treatment of, and therapeutic support for, schizophrenia, bipolar disorder and other psychoses. Considering that olanzapine acts on the dopaminergic receptor and this receptor is detected in germ cells, the present study aims to investigate the effects of treatment with different doses of olanzapine on spermatogenesis, plasma testosterone and weight of androgen-dependent organs in rats. Results showed reduced plasma testosterone levels, and reduced testis, epididymis and prostate weights. Histopathologic and histomorphometric analysis of spermatogenesis indicated testicular degeneration. Furthermore, germ cell desquamation, syncytial multinucleated cells, Sertoli cell vacuolization and presence of necrotic and apoptotic germ cells wwew observed. Olanzapine treatment in rats promoted endocrinological changes and lesions in the testis, leading to a disturbance in spermatogenesis.
authors.affiliation: Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Simone
authors.initials: S
authors.lastname: de Siqueira Bringel
authors.forename: Adelmar Afonso
authors.initials: AA
authors.lastname: de Amorim Júnior
authors.forename: Marleyne José Afonso Accioly Lins
authors.initials: MJ
authors.lastname: Amorim
authors.forename: Lorena Tavares
authors.initials: LT
authors.lastname: Brito
authors.forename: Rosana Nogueira
authors.initials: RN
authors.lastname: Morais
authors.forename: Sandra Maria
authors.initials: SM
authors.lastname: de Torres
authors.forename: Bruno Mendes
authors.initials: BM
authors.lastname: Tenorio
authors.forename: Valdemiro Amaro
authors.initials: VA
authors.lastname: da Silva Junior
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D001569:Benzodiazepines / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002452:Cell Count; D004822:Epididymis / Q000187:drug effects / Q000473:pathology; D005832:Genital Diseases, Male / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D053609:Lethargy / Q000139:chemically induced; D008297:Male; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D000077152:Olanzapine; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012708:Sertoli Cells / Q000187:drug effects / Q000473:pathology; D013090:Spermatocytes / Q000187:drug effects / Q000473:pathology; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013739:Testosterone / Q000097:blood
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D013739:Testosterone; D000077152:Olanzapine