title: [Assessement of the usefulness of whole body scintigraphy after administration of 6 MBq of 131I in the diagnostic of breast cancer].
abstract: BACKGROUND
  Sodium-iodine symporter (NIS) belongs to a large family of natrium dependent ion transporters found in normal thyroid cells located on the basilar membrane of tyreocytes. Under physiologic conditions, the NIS is also present in other tissues: salivary glands, gastric mucosa, mammary glands during lactation, and vascular plexus of the fourth ventricle. NIS expression has also been found in many tumors, including breast cancer.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the usefulness of whole body scintigraphy after administration of relatively low activity of 131I (6 MBq)in the diagnostics of breast cancer.
  
  
  METHODS
  The study included nine women with breast cancer, aged 38-73 years (mean 55.6 +/- 11.7 years) and a control group of 14 women aged 29-84 years (mean 48.8 +/- 16.7 years). The uptake of radioiodine in whole body scintigraphy 24 hours after administration of 131I radioiodine (6 MBq) was compared between the control group and breast cancer patients. No pharmaceuticals reducing thyroid iodine uptake or increasing NIS expression were used.
  
  
  RESULTS
  Whole body scans using 6 MBq 131I activity revealed no focal radioiodine uptake outside the thyroid tissue in patients with breast cancer as well as volunteers from the control group.
  
  
  CONCLUSIONS
  Whole body scintigraphy using 131I, dosed at 6 MBq, with no additional treatment increasing extrathyroidal uptake of radioiodine, appears to be ineffective in the imaging of breast cancer.
authors.affiliation: Katedra i Klinika Endokrynologii UJCM. filgol@cm-uj.krakow.pl
authors.forename: Filip
authors.initials: F
authors.lastname: Gołkowski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Sokołowski
authors.forename: Justyna
authors.initials: J
authors.lastname: Gil
authors.forename: Marta
authors.initials: M
authors.lastname: Kostecka-Matyja
authors.forename: Paweł
authors.initials: P
authors.lastname: Basta
authors.forename: Anna
authors.initials: A
authors.lastname: Sowa-Staszczak
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Szybiński
authors.forename: Alicja
authors.initials: A
authors.lastname: Hubalewska-Dydejczyk
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008875:Middle Aged; D011877:Radionuclide Imaging; D027981:Symporters / Q000032:analysis; D014915:Whole-Body Counting; D000099209:Sodium-Iodide Symporters
chemical_list: D007457:Iodine Radioisotopes; D027981:Symporters; D000099209:Sodium-Iodide Symporters