title: Undifferentiated high-grade pleomorphic sarcoma in a blind eye with a silicone prosthesis implant: a clinico-pathologic study.
abstract: OBJECTIVE
  To describe a rare case of an orbital undifferentiated sarcoma arising in an eviscerated eye socket with a silicone implant.
  
  
  METHODS
  The clinical and histopathological findings of the case are reviewed and presented.
  
  
  RESULTS
  A patient who had undergone post-traumatic evisceration of the right eye and a silicone prosthesis implant 8 years earlier, presented to our observation with a painful eye, on which a brownish, bleeding mass, measuring 1 cm in diameter, was evident. After removal of the silicone prosthesis, the mass was found to arise from the scleral socket. Histopathological analysis demonstrated a malignant tumor composed of markedly pleomorphic cells with a high mitotic rate. An undifferentiated high-grade pleomorphic sarcoma was diagnosed. Complete right orbital exenteration was performed and the patient underwent radiotherapy
  
  
  CONCLUSIONS
  This is the first report of an undifferentiated high-grade pleomorphic sarcoma arising from a scleral socket with a silicone implant.
authors.affiliation: Department of Anatomopathology, University of Bari, Bari, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Piscitelli
authors.forename: Enrica
authors.initials: E
authors.lastname: Ruggeri
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Fiore
authors.forename: Roberta
authors.initials: R
authors.lastname: Rossi
authors.forename: Silvana
authors.initials: S
authors.lastname: Guerriero
mesh_terms: D003937:Diagnosis, Differential; D017234:Eye Evisceration; D005137:Eye, Artificial / Q000009:adverse effects*; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012828:Silicones
chemical_list: D012828:Silicones