title: New proposal for the treatment of viral warts with intralesional injection of 5-aminolevulinic acid photodynamic therapy.
abstract: BACKGROUND
  Although photodynamic therapy (PDT) using intralesional injection (ILI) can theoretically enhance the efficacy of the PDT, the effect of ILI-PDT on warts has not been reported in the literature so far.
  
  
  METHODS
  Eight patients with multiple viral warts were enrolled in the study. PDT was performed after the incubation for 1 h, followed by the ILI of aminolevulinic acid (ALA) into the warts. The treatment was repeated at 2-3 week intervals.
  
  
  RESULTS
  Fifty percent of patients showed good to cure response. Complete remission was observed in two patients. There was no apparent correlation between the initial severity of warts and the likelihood of response. No one reported severe adverse reaction.
  
  
  CONCLUSIONS
  The present study suggests that intralesional administration of ALA might be a safe and effective treatment option of thick treatment-resistant warts and can be performed with a shorter incubation period.
authors.affiliation: Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Sun Ji
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jong Ik
authors.initials: JI
authors.lastname: Hwang
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Lee
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Park
authors.forename: Baik Kee
authors.initials: BK
authors.lastname: Cho
mesh_terms: D000293:Adolescent; D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D002648:Child; D005260:Female; D006801:Humans; D015552:Injections, Intralesional / Q000379:methods; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D016896:Treatment Outcome; D014860:Warts / Q000188:drug therapy* / Q000821:virology; D055815:Young Adult
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid