title: Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy.
abstract: OBJECTIVE
  To compare the frequencies of attacks before and after immunomodulatory therapy (IMT) with mycophenolate mofetil (MMF) in recurrent punctate inner choroidopathy (PIC) and to report fundus autofluorescence (FAF) findings.
  
  
  METHODS
  Eight patients who had at least two recurrent episodes of increased activity before MMF and 12 months of documented clinical course before and after MMF were included. The frequencies of attacks before and after MMF were compared. FAF images evaluated.
  
  
  RESULTS
  Before MMF, the 8 patients experienced 19 attacks of recurrent disease activity; during MMF therapy, 3 (38%) patients experienced 6 recurrent episodes. The attack frequencies were 1.09 ± 0.75 before and 0.23 ± 0.32 during treatment (p = .036). Among the 6 patients who had FAF, surrounding hyperautofluorescent halo was detected in 4 and recurrence occurred in 2 who did not show any changes on the intensity during treatment.
  
  
  CONCLUSIONS
  In the index study, the employment of MMF has decreased frequency of attacks in recurrent PIC. FAF may be employed to monitor and predict the response to treatment.
authors.affiliation: Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
authors.forename: Peykan
authors.initials: P
authors.lastname: Turkcuoglu
authors.forename: Peter Y
authors.initials: PY
authors.lastname: Chang
authors.forename: Zubir S
authors.initials: ZS
authors.lastname: Rentiya
authors.forename: Roomasa
authors.initials: R
authors.lastname: Channa
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ibrahim
authors.forename: Elham
authors.initials: E
authors.lastname: Hatef
authors.forename: Raafay
authors.initials: R
authors.lastname: Sophie
authors.forename: Ama
authors.initials: A
authors.lastname: Sadaka
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wang
authors.forename: Yasir J
authors.initials: YJ
authors.lastname: Sepah
authors.forename: Diana V
authors.initials: DV
authors.lastname: Do
authors.forename: C Stephen
authors.initials: CS
authors.lastname: Foster
authors.forename: Quan Dong
authors.initials: QD
authors.lastname: Nguyen
mesh_terms: D000328:Adult; D015862:Choroid Diseases / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D005453:Fluorescence; D005654:Fundus Oculi; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012008:Recurrence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D007155:Immunologic Factors; D009173:Mycophenolic Acid