title: Brain plasticity and disease: a matter of inhibition.
abstract: One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during development and in adulthood. This paper summarizes recent findings showing that the inhibition-excitation balance controls adult brain plasticity and is at the core of the pathogenesis of neurodevelopmental disorders like autism, Down syndrome, and Rett syndrome.
authors.affiliation: National Research Council (CNR), Neuroscience Institute, Via Moruzzi 1, I-56124 Pisa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Baroncelli
authors.forename: Chiara
authors.initials: C
authors.lastname: Braschi
authors.forename: Maria
authors.initials: M
authors.lastname: Spolidoro
authors.forename: Tatjana
authors.initials: T
authors.lastname: Begenisic
authors.forename: Lamberto
authors.initials: L
authors.lastname: Maffei
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sale
mesh_terms: D001321:Autistic Disorder / Q000503:physiopathology; D001921:Brain / Q000502:physiology*; D004314:Down Syndrome / Q000503:physiopathology; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D015518:Rett Syndrome / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D005680:gamma-Aminobutyric Acid