title: Could higher doses of isotretinoin reduce the frequency of treatment failure in patients with acne?
authors.affiliation: NorthShore University Health System, Evanston, Illinois.
authors.forename: Jacquelyn
authors.initials: J
authors.lastname: Coloe
authors.affiliation: NorthShore University Health System, Evanston, Illinois.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Du
authors.affiliation: Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: morrell@med.unc.edu.
authors.forename: Dean S
authors.initials: DS
authors.lastname: Morrell
mesh_terms: D000152:Acne Vulgaris / Q000175:diagnosis / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D016001:Confidence Intervals; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D015474:Isotretinoin / Q000009:adverse effects / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D020714:Maximum Tolerated Dose; D015999:Multivariate Analysis; D016017:Odds Ratio; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017211:Treatment Failure; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin