title: Association of the catechol-O-methyl transferase gene Val158Met polymorphism with blood pressure and prevalence of hypertension: interaction with dietary energy intake.
abstract: BACKGROUND
  Previous studies of a functional variant of the catechol-O-methyl transferase (COMT) gene, Val158Met, have provided inconsistent results with regard to blood pressure or hypertension. We examined the effect of this variant, the considering environmental factors of daily salt and energy intakes.
  
  
  METHODS
  A total of 735 Japanese men (mean age, 47 years) were recruited from two separate occupational cohorts from Kanagawa and Kyoto prefectures. Participants were genotyped for the presence of COMT Val158Met (rs4680, G/A). Daily salt and energy intakes were evaluated by the food frequency questionnaire (FFQ).
  
  
  RESULTS
  Met/Met carriers had higher adjusted systolic blood pressure (SBP) (+4.79 mm Hg, P < 0.001) and diastolic blood pressure (DBP) (+2.33 mm Hg, P = 0.001) than Met/Val or Val/Val carriers. There was a significant association between being a Met/Met carrier and having a higher prevalence of hypertension (odds ratio = 2.448, 95% confidence interval = 1.426-4.205, P = 0.001). When salt and energy intakes were dichotomized, the effect of Val158Met on hypertension was observed only in the high-energy intake group, and was equivalent between low- and high-salt groups.
  
  
  CONCLUSIONS
  The Met allele of COMT Val158Met is associated with higher blood pressure and higher prevalence of hypertension in Japanese men, and energy intake may interact with this effect.
authors.affiliation: Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Nay Chi
authors.initials: NC
authors.lastname: Htun
authors.forename: Koichi
authors.initials: K
authors.lastname: Miyaki
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Song
authors.forename: Shinobu
authors.initials: S
authors.lastname: Ikeda
authors.forename: Takuro
authors.initials: T
authors.lastname: Shimbo
authors.forename: Masaaki
authors.initials: M
authors.lastname: Muramatsu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002149:Energy Intake; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000235:genetics; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D017673:Sodium Chloride, Dietary; D002394:Catechol O-Methyltransferase