title: Clinical outcome and quality of life after surgery for peri-acetabular metastases.
abstract: We set out to determine the impact of surgery on quality of life and function in patients who had undergone surgery for symptomatic peri-acetabular metastases. From a prospective database we retrospectively reviewed 46 consecutive patients who had been treated operatively between June 2003 and June 2009. The mean age of the patients was 56.4 years (20 to 73) and the mean post-operative follow-up was 19.2 months (4 to 70). Functional evaluation and quality-of-life assessments were performed. At the most recent follow-up, 26 patients (56.5%) were alive. Their median survival time was 25.0 months. Ten major postoperative complications had occurred in eight patients (17.4%). The mean post-operative Musculoskeletal Tumor Society score (MSTS 93) was 56.3% (6.7% to 90.0%). Improvement in the Eastern Cooperative Oncology Group (ECOG) performance status was seen in 32 patients (69.6%). On the European Organisation for Research and Treatment of Cancer core quality-of-life questionnaire (QLQ-C30) measure of global health status there was a statistically significant improvement from the patients' pre-operative status (42.8 (SD 13.7)) to that found at the latest follow-up (58.0 (SD 12.5)) (p = 0.001). The only statistically significant change in the nine symptom domains of the QLQ-C30 was a reduction in the mean level of pain (from 59.1 to 29.5 (out of 100)) (p < 0.001). Surgery for patients with peri-acetabular metastases reduces pain and improves their quality of life, and has a low rate of surgical complications.
authors.affiliation: Musculoskeletal Tumor Centre, Peking University People's Hospital, 11# Xizhimen Nan Road, Xicheng District, Beijing 100044, China.
authors.forename: T
authors.initials: T
authors.lastname: Ji
authors.forename: W
authors.initials: W
authors.lastname: Guo
authors.forename: R-L
authors.initials: RL
authors.lastname: Yang
authors.forename: S
authors.initials: S
authors.lastname: Tang
authors.forename: X
authors.initials: X
authors.lastname: Sun
mesh_terms: D000077:Acetabulum / Q000000981:diagnostic imaging / Q000601:surgery*; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000534:rehabilitation / Q000556:secondary* / Q000601:surgery*; D018450:Disease Progression; D004812:Epidemiologic Methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D010148:Intractable Pain / Q000601:surgery; D011183:Postoperative Complications; D011788:Quality of Life; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult