title: Antibacterial and antifungal efficacy of fatty acid methyl esters from the leaves of Sesuvium portulacastrum L.
abstract: OBJECTIVE
  The fatty acid methyl esters (FAME extract) from Sesuvium (S.) portulacastrum was studied for its fatty acid composition and antimicrobial activity against human pathogenic microorganisms.
  
  
  RESULTS
  The gas chromatographic analysis of FAME extract revealed the presence of palmitic acid with the highest relative percentage (31.18%), followed by oleic acid (21.15%), linolenic acid (14.18%) linoleic acid (10.63%), myristic acid (6.91%) and behenic acid (2.42%). The saturated fatty acids were higher than the unsaturated fatty acids. FAME extract showed the highest antibacterial and anticandidal activities and moderate antifungal activity against the tested microorganisms. The highest mean zone of inhibition (16.3 mm) and the lowest MIC (0.25 mg/ml) and MBC (0.5 mg/ml) values were recorded against Bacillus subtilis. The lowest mean zone of inhibition (8.8 mm) and the highest MIC (8 mg/ml) and MFC (16 mg/ml) values were recorded against Aspergillus fumigatus and Aspergillus niger.
  
  
  CONCLUSIONS
  The results of the present study justify the use of S. portulacastrum in traditional medicine and the FAME extract can be used as a potential antimicrobial agent against the tested human pathogenic microorganisms.
authors.affiliation: Department of Botany, Annamalai University, Annamalai Nagar-608 002, Tamil Nadu, India.
authors.forename: M
authors.initials: M
authors.lastname: Chandrasekaran
authors.forename: A
authors.initials: A
authors.lastname: Senthilkumar
authors.forename: V
authors.initials: V
authors.lastname: Venkatesalu
mesh_terms: D035722:Aizoaceae / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002849:Chromatography, Gas; D052978:Disk Diffusion Antimicrobial Tests; D004952:Esters / Q000302:isolation & purification / Q000494:pharmacology*; D005227:Fatty Acids / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects / Q000254:growth & development; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004952:Esters; D005227:Fatty Acids; D010936:Plant Extracts