title: Molecular epidemiology of a hepatitis C virus outbreak in a leprosy sanatorium in Japan.
abstract: The hepatitis C virus (HCV) outbreak that occurred between 1940 and 1999 in a closed leprosy sanatorium located on a small island in Japan was analyzed. The analysis of 318 nucleotides in the NS5B region of HCV allowed us to establish the existence of at least three different HCV strains in this sanatorium.
authors.affiliation: Department of Internal Medicine, Kojin Hospital, Nagoya, Japan. hteramoto@Kojin-hospital.jp
authors.forename: Hidemi
authors.initials: H
authors.lastname: Teramoto
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shiogama
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Mizutani
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Inada
authors.forename: Toshio
authors.initials: T
authors.lastname: Kamahora
authors.forename: Masanao
authors.initials: M
authors.lastname: Makino
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tsutsumi
mesh_terms: D016000:Cluster Analysis; D003428:Cross Infection / Q000453:epidemiology* / Q000821:virology; D004196:Disease Outbreaks; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D017720:Molecular Epidemiology; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D017361:Viral Nonstructural Proteins / Q000235:genetics; D012324:RNA-Dependent RNA Polymerase
chemical_list: D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase