title: Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN.
abstract: Genetic associations of fatty acid composition with exonic single nucleotide polymorphisms (SNPs) in the gene encoding fatty acid synthase (FASN) were examined using 513 Korean cattle. All five individual SNPs of g.12870 T>C, g.13126 T>C, g.15532 C>A, g.16907 T>C and g.17924 G>A were associated with a variety of fatty acid compositions and further with marbling score (P < 0.05). Their genotypes of CC, TT, AA, TT, and GG were associated with increased monounsaturated fatty acids and with decreased saturated fatty acids (P < 0.05). The genotypes at all the SNPs also increased marbling score (P < 0.05). Further genetic associations with fatty acid composition suggested that homozygous genotype with the haplotype of ATG at g.15532, g.16907, and g.17924 in a linkage disequilibrium block increased monounsaturated fatty acids and marbling score (P < 0.05). We concluded that the five exonic SNPs of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents. Their genotypes of CC, TT, AA, TT, and GG and haplotype of ATG at g.15532, g.16907, and g.17924 were recommended for genetic improvement of beef quality.
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 712-749, South Korea.
authors.forename: Dongyep
authors.initials: D
authors.lastname: Oh
authors.forename: Yoonseok
authors.initials: Y
authors.lastname: Lee
authors.forename: Boomi
authors.initials: B
authors.lastname: La
authors.forename: Jungsou
authors.initials: J
authors.lastname: Yeo
authors.forename: Euiryong
authors.initials: E
authors.lastname: Chung
authors.forename: Younyoung
authors.initials: Y
authors.lastname: Kim
authors.forename: Chaeyoung
authors.initials: C
authors.lastname: Lee
mesh_terms: D050154:Adiposity / Q000235:genetics; D000818:Animals; D002417:Cattle / Q000235:genetics*; D005091:Exons / Q000235:genetics*; D064429:Fatty Acid Synthases / Q000235:genetics*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D006239:Haplotypes / Q000235:genetics; D015810:Linkage Disequilibrium / Q000235:genetics; D008460:Meat / Q000032:analysis*; D009132:Muscles / Q000378:metabolism; D009711:Nucleotides / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D056910:Republic of Korea
chemical_list: D005227:Fatty Acids; D009711:Nucleotides; D064429:Fatty Acid Synthases