title: Synthesis of the pyridine core of cyclothiazomycin.
abstract: A highly convergent synthesis of the pyridine core of the thiopeptide antibiotic cyclothiazomycin has been developed based on a [2+2+2] cyclotrimerization key step. The regioselective assembly of the heterocyclic center of this important class of antibiotics takes advantage of a temporary silicon tether and the ruthenium-catalyzed cyclotrimerization reaction of a diyne and an electron-poor thiazole nitrile.
authors.affiliation: North Carolina State University, Department of Chemistry, Raleigh, North Carolina 27695-8204, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zou
authors.forename: Qingyang
authors.initials: Q
authors.lastname: Liu
authors.forename: Alexander
authors.initials: A
authors.lastname: Deiters
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; D011725:Pyridines; D013844:Thiazoles; C069913:cyclothiazomycin; C023666:pyridine