title: Cheminformatics-based selection and synergism of herbal extracts with anticancer agents on drug resistance tumor cells-ACHN and A2780/cp cell lines.
abstract: The treatment of cancer usually involves lethal effect on normal body cells as side effects. Cheminformatics methodology can play a significant role in biomed/clinical scientific research. Similarity searching is a standard cheminformatics tool in drug discovery area and database design. In this study, five novel herbal extracts in combination with doxorubicin and cisplatin have been used to sensitize ACHN and A2780/cp cells. These herbal extracts have been selected on the basis of novel cheminformatics methodology and assayed for the first time. The findings confirmed predicted outcomes from the in silico research and the results introduced may bring to use the effects of these herbs in reversing of multidrug resistance (MDR) phenomenon.
authors.affiliation: Drug Design and Bioinformatics Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, #69, Pasteur Avenue, P.O. Box 1316943551, Tehran, Iran.
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Ghavami
authors.forename: Soroush
authors.initials: S
authors.lastname: Sardari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ali Shokrgozar
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D028082:Boraginaceae / Q000737:chemistry; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D019295:Computational Biology / Q000379:methods*; D004317:Doxorubicin / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004357:Drug Synergism; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D048088:Informatics; D020128:Inhibitory Concentration 50; D007680:Kidney Neoplasms / Q000188:drug therapy*; D031625:Morus / Q000737:chemistry; D028521:Musa / Q000737:chemistry; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*; D012756:Sheep
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D004317:Doxorubicin; D002945:Cisplatin