title: Direct transformation of N,N-dimethylformamide to -CN: Pd-catalyzed cyanation of heteroarenes via C-H functionalization.
abstract: This paper describes the direct cyanation of indoles and benzofurans employing N,N-dimethylformamide (DMF) as both reagent and solvent. Isotopic labeling experiments indicated that both the N and the C of the cyano group derived from DMF. This transformation offers an alternative method for preparing aryl nitriles, though it is currently limited in scope to indoles and benzofurans.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
authors.forename: Shengtao
authors.initials: S
authors.lastname: Ding
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D004126:Dimethylformamide; D005559:Formamides / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
chemical_list: D001572:Benzofurans; D003486:Cyanides; D005559:Formamides; D007211:Indoles; D010165:Palladium; D004126:Dimethylformamide