title: Narrow band imaging hysteroscopy: a comparative study using randomized video images.
abstract: Narrow band imaging (NBI) has been used in the gastrointestinal endoscopy field as a novel endoscopic imaging technique and has contributed to improved qualitative diagnosis and detection of lesions. However, there are only a few studies of use of NBI in the gynecology field. We applied NBI in flexible hysteroscopy at our outpatient clinic and evaluated the utility of NBI hysteroscopy for diagnosis of malignant endometrial lesions by comparison of the sensitivity and specificity between white light alone and white light+NBI using hysteroscopic video images. The subjects were 65 patients with a suspected endometrial lesion in the uterine cavity. These patients underwent flexible hysteroscopy using NBI in addition to conventional white light. Video images from 65 patients were edited into two groups, white light alone (WL group) and white light+NBI (NBI group) (130 images in total). Computerized block randomization of the order was then performed. Four raters independently diagnosed the images without use of other clinical information. Using the pathological diagnosis as the gold standard, we evaluated the sensitivity and specificity of diagnosis of atypical endometrial hyperplasia (AEH) or endometrial carcinoma compared between the WL and NBI groups. The sensitivity of diagnosis of AEH or endometrial carcinoma was numerically higher in the NBI group for all raters, and the average sensitivity was significantly higher in the NBI group compared to the WL group (78.6% vs. 63.7%, P<0.001). The specificity for each rater and the average specificity were comparable between the two groups. Compared to white light hysteroscopy, NBI hysteroscopy had a higher sensitivity for diagnosis of AEH or endometrial carcinoma without loss of specificity. This suggests that NBI hysteroscopy may be more useful than white light hysteroscopy for endoscopic diagnosis of malignant endometrial lesions.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Iori
authors.initials: I
authors.lastname: Kisu
authors.forename: Kouji
authors.initials: K
authors.lastname: Banno
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Asuka
authors.initials: A
authors.lastname: Ono
authors.forename: Kenta
authors.initials: K
authors.lastname: Masuda
authors.forename: Arisa
authors.initials: A
authors.lastname: Ueki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nomura
authors.forename: Akira
authors.initials: A
authors.lastname: Hirasawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Abe
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kouyama
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Susumu
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
mesh_terms: D000368:Aged; D003952:Diagnostic Imaging / Q000379:methods*; D004714:Endometrial Hyperplasia / Q000175:diagnosis; D016889:Endometrial Neoplasms / Q000175:diagnosis; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D007089:Image Enhancement / Q000379:methods; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014741:Video Recording