title: PCB congeners and pesticides and female fecundity, New York State Angler Prospective Pregnancy Study.
abstract: Consumption of PCB-contaminated sport fish from Lake Ontario has been reported to be associated with diminished female fecundity. To identify Polychlorinated biphenyl (PCB) congeners and other pesticides that might be associated with reduced fecundity, we followed 102 women aged 20-34 years attempting pregnancy who completed daily diaries for 12 at risk menstrual cycles. Fecundity referred to time-to-pregnancy (TTP) or the number of at risk menstrual cycles required for pregnancy. Blood specimens were obtained for 88 (86%) women and were analyzed using gas chromatography and electron capture for 66 PCB congeners and seven pesticides. Laboratory values were recovery, background and fat corrected prior to natural log transformation. Using stepwise discriminant analysis, congeners IUPAC #205 and #206 and hexaclorobenzene were significantly and positively associated with increasing TTP when women were categorized as becoming pregnant in the first or first three at risk menstrual cycles, respectively. Congeners #205 and #206 are reported to have (anti) estrogenic structural activity.
authors.affiliation: Departments of Social and Preventive Medicine and Pharmacology and Toxicology, University at Buffalo, State of New York, Buffalo, NY 14214, USA.
authors.forename: Germaine M
authors.initials: GM
authors.lastname: Buck
authors.forename: John E
authors.initials: JE
authors.lastname: Vena
authors.forename: Hebe B
authors.initials: HB
authors.lastname: Greizerstein
authors.forename: John M
authors.initials: JM
authors.lastname: Weiner
authors.forename: Bridget
authors.initials: B
authors.lastname: McGuinness
authors.forename: Pauline
authors.initials: P
authors.lastname: Mendola
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Kostyniak
authors.forename: Mya
authors.initials: M
authors.lastname: Swanson
authors.forename: Michael S
authors.initials: MS
authors.lastname: Bloom
authors.forename: James R
authors.initials: JR
authors.lastname: Olson