title: Crosstissue coexpression network of aging.
abstract: Aging is characterized by the interlocking decay of biological functions over time. Microarrays have been successful in elucidating some of the genome-wide changes that occur with age. Using the AGEMAP dataset that catalogs changes in gene expression as a function of age in 16 tissues in mice, we identified tissue-specific aging genes. Coordinated aging processes across different tissues then were clarified in crosstissue coexpression networks on both the gene and pathway levels. Our findings provide more concrete information about coordinated aging across different tissues. By bridging gene-level and tissue-level research, this study could help identify targets for attenuation of critical aging-related genes, pathways, or networks for antiaging intervention.
authors.affiliation: Department of Ophthalmology, Yangpu District Central Hospital, Shanghai, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Lu
authors.initials: L
authors.lastname: Xie
authors.forename: Xiao
authors.initials: X
authors.lastname: Dong
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Cai
authors.forename: Yi-Xue
authors.initials: YX
authors.lastname: Li
mesh_terms: D000375:Aging / Q000235:genetics*; D000465:Algorithms; D000818:Animals; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D051379:Mice; D009928:Organ Specificity / Q000235:genetics