title: [Effect of oxytocin on uterine fibroids treated by ultrasound ablation].
abstract: OBJECTIVE
  To explore the effect of oxytocin on uterine fibroids treated by ultrasound ablation.
  
  
  METHODS
  Eighty-two single points in 29 uterine fibroids from 26 patients were sonicated with magnetic resonance imaging guided by high intensity focused ultrasound before and after using oxytocin. The required total energy, sonication time required to reach 60°C and the acoustic energy for increasing 1°C of temperature at the single point before and after using oxytocin were compared.
  
  
  RESULTS
  Before intravenous infusion of oxytocin, the average total sonication energy required to reach 60°C was (5320 ± 910) J and it took (21 ± 20) seconds for sonicating a single point, the energy required for increasing 1°C was (255 ± 302) J. In contrast, after intravenous infusion of oxytocin, the average total sonication energy required to reach 60°C was (2890 ± 325) J, and it took (12 ± 7) seconds for sonicating a single point, the energy required for increasing 1°C was (126 ± 94) J. Those three index all reached statistical difference (P = 0.002, P = 0.001, P = 0.002, respectively).
  
  
  CONCLUSIONS
  It seemed that Oxytocin could significantly decrease the energy required for ablating uterine fibroids, shorten treatment time and improve the treatment efficiency.
authors.affiliation: College of Biomedical Engineering, Chongqing Medical University, China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Huang
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.forename: Ying-jiang
authors.initials: YJ
authors.lastname: Liu
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhi-biao
authors.initials: ZB
authors.lastname: Wang
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D007275:Injections, Intravenous; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008874:Midazolam / Q000008:administration & dosage; D010121:Oxytocin / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D014599:Uterus / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D003287:Contrast Media; D010121:Oxytocin; D008874:Midazolam; D005283:Fentanyl