title: Serum asymmetric dimethylarginine, nitrate, vitamin B(12), and homocysteine levels in individuals with pulmonary embolism.
abstract: We aimed to analyze the pre- and posttreatment serum asymmetric dimethylarginine (ADMA), nitrate (NO(3)), vitamin B(12) and homocysteine levels in pulmonary embolism (PTE) patients and to determine the prognostic value of these variables in predicting chronic thromboembolic pulmonary hypertension (CTEPH). This study was conducted in 64 patients. The patients were classified into the two groups: patients with normal pulmonary artery pressure (PAP) (group I) and patients with high PAP with persistent lung perfusion defects or who died at the end of 3 months of therapy (group II). We found statistically significant differences between two groups with respect to the partial oxygen pressure, the oxygen saturation, and the PAP, but there was no difference between the two groups with respect to the pretreatment ADMA, NO(3), or homocysteine levels. The vitamin B(12) levels were higher in group II. The NO(3) levels increased and the ADMA and vitamin B(12) levels decreased with treatment in both groups. These results suggest that these parameters are not predictive of the development of CTEPH.
authors.affiliation: Department of Pulmonary Medicine, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Altuntaş
authors.forename: Figen
authors.initials: F
authors.lastname: Atalay
authors.forename: Murat
authors.initials: M
authors.lastname: Can
authors.forename: Remzi
authors.initials: R
authors.lastname: Altın
authors.forename: Meltem
authors.initials: M
authors.lastname: Tor
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011237:Predictive Value of Tests; D011379:Prognosis; D011655:Pulmonary Embolism / Q000097:blood* / Q000401:mortality* / Q000628:therapy; D011669:Pulmonary Wedge Pressure; D012307:Risk Factors; D014805:Vitamin B 12 / Q000097:blood*
chemical_list: D015415:Biomarkers; D009566:Nitrates; D006710:Homocysteine; C018524:N,N-dimethylarginine; D001120:Arginine; D014805:Vitamin B 12; D010100:Oxygen