title: Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach.
abstract: Obesity is currently considered a serious public health issue due to its strong impact on health, economy, and quality of life. It is considered a chronic low-grade inflammation state and is directly involved in the genesis of metabolic disturbances, such as insulin resistance and dyslipidemia, which are well-known risk factors for cardiovascular disease. Furthermore, there is evidence that genetic variation that predisposes to inflammation and metabolic disturbances could interact with environmental factors, such as diet, modulating individual susceptibility to developing these conditions. This paper aims to review the possible interactions between diet and single-nucleotide polymorphisms (SNPs) in genes implicated on the inflammatory response, lipoprotein metabolism, and oxidative status. Therefore, the impact of genetic variants of the peroxisome proliferator-activated receptor-(PPAR-)gamma, tumor necrosis factor-(TNF-)alpha, interleukin (IL)-1, IL-6, apolipoprotein (Apo) A1, Apo A2, Apo A5, Apo E, glutathione peroxidases 1, 2, and 4, and selenoprotein P exposed to variations on diet composition is described.
authors.affiliation: Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo, 715, 01246-904, São Paulo, SP, Brazil.
authors.forename: Maira Ladeia R
authors.initials: ML
authors.lastname: Curti
authors.forename: Patrícia
authors.initials: P
authors.lastname: Jacob
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: Borges
authors.forename: Marcelo Macedo
authors.initials: MM
authors.lastname: Rogero
authors.forename: Sandra Roberta G
authors.initials: SR
authors.lastname: Ferreira