title: esfMRI of the upper STS: further evidence for the lack of electrically induced polysynaptic propagation of activity in the neocortex.
abstract: Combining electrical stimulation with fMRI (esfMRI) has proven to be an important tool to study the global effects of electrical stimulation on neural networks in the brain. Here we extend our previous studies to stimulating the upper superior temporal sulcus (STS) in the anesthetized monkey. Our results show that stimulating area V5/MT and surrounding areas leads to positive BOLD responses in the majority of cortical areas known to receive direct/monosynaptic connections from the stimulation site. We confirm our previous results from stimulating primary visual cortex that the propagation of electrically induced activity is limited in its transsynaptic propagation to the first synapse also for extrastriate areas.
authors.affiliation: Department of Cognitive Neurology, HIH for Clinical Brain Research, Tuebingen 72076, Germany. fahad.sultan@uni-tuebingen.de
authors.forename: Fahad
authors.initials: F
authors.lastname: Sultan
authors.forename: Mark
authors.initials: M
authors.lastname: Augath
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Murayama
authors.forename: Andreas S
authors.initials: AS
authors.lastname: Tolias
authors.forename: Nikos
authors.initials: N
authors.lastname: Logothetis
mesh_terms: D000818:Animals; D004558:Electric Stimulation / Q000379:methods*; D007395:Interneurons / Q000502:physiology; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019579:Neocortex / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*