title: Effect of dietary fish oil on atrial fibrillation after cardiac surgery.
abstract: An open-label study reported that ingestion of a fish oil concentrate decreased the incidence of atrial fibrillation (AF) after coronary artery bypass grafting (CABG) surgery. However, a general cardiac surgery population involves valve and CABG surgeries. We undertook a double-blinded randomized controlled trial to examine the effectiveness of fish oil supplementation on the incidence of postsurgical AF after CABG and valve procedures. The primary end point was incidence of AF in the first 6 days after surgery. Two hundred patients were randomized to receive fish oil (providing 4.6 g/day of long-chain ω-3 fatty acids) or a control oil starting 3 weeks before surgery; 194 subjects completed the study, with 47 of 97 subjects in the control group and 36 of 97 subjects in the fish oil group developing AF (odds ratio 0.63, 95% confidence interval [CI] 0.35 to 1.11). There was a nonstatistically significant delay in time to onset of AF in the fish oil group (hazard ratio 0.66, 95% CI 0.43 to 1.01). There was a significant decrease in mean length of stay in the intensive care unit in the fish oil group (ratio of means 0.71, 95% CI 0.56 to 0.90). In conclusion, in a mixed cardiac surgery population, supplementation with dietary fish oil did not result in a significant decrease in the incidence of postsurgical AF. However, there was a significant decrease in time spent in the intensive care unit.
authors.affiliation: Discipline of Medicine, University of Adelaide, Adelaide, Australia.
authors.forename: Aaron L
authors.initials: AL
authors.lastname: Farquharson
authors.forename: Robert G
authors.initials: RG
authors.lastname: Metcalf
authors.forename: Prashanthan
authors.initials: P
authors.lastname: Sanders
authors.forename: Robert
authors.initials: R
authors.lastname: Stuklis
authors.forename: James R M
authors.initials: JR
authors.lastname: Edwards
authors.forename: Robert A
authors.initials: RA
authors.lastname: Gibson
authors.forename: Leslie G
authors.initials: LG
authors.lastname: Cleland
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Sullivan
authors.forename: Michael J
authors.initials: MJ
authors.lastname: James
authors.forename: Glenn D
authors.initials: GD
authors.lastname: Young
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000517:prevention & control*; D006348:Cardiac Surgical Procedures; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007902:Length of Stay / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011183:Postoperative Complications / Q000517:prevention & control*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D005395:Fish Oils; D010919:Placebos