title: Diffuse uremic tumoral calcinosis in a patient on long-term hemodialysis.
abstract: Tumoral calcinosis is an uncommon and severe complication of hemodialysis therapy. The most important pathogenic factor involved in uremic tumoral calcinosis is an increase in calcium-phosphorus product, not necessarily related to hyperparathyroidism. We report here a patient on hemodialysis who presented with increasing multifocal and uncommon sites of massive calcifications. The patient was examined, and a diagnosis of uremic tumor calcinosis was made. The patient was treated with the noncalcemic phosphate binder sevelamer, a strict diet, multiple hemodialysis sessions per week, and a low calcium dialysate, with improvement on biological findings a decrease in the volume of some tumors on his fingers and a global stable disease. Some nodes in hands and feet disappeared; in other sites, their diameter was reduced, and the largest nodule decreased from 5- to 2-cm diameter.
authors.affiliation: Rheumatology Department, Centre Hospitalier Universitaire, Hassan II de Fez, Fez, Morocco. nessrine_rhumato@hotmail.fr
authors.forename: Nessrine
authors.initials: N
authors.lastname: Akasbi
authors.forename: Tarik Sqalli
authors.initials: TS
authors.lastname: Houssaini
authors.forename: Samira
authors.initials: S
authors.lastname: Rabhi
authors.forename: Mariam
authors.initials: M
authors.lastname: Lahlou
authors.forename: Amal
authors.initials: A
authors.lastname: Boukhrissa
authors.forename: Latifa
authors.initials: L
authors.lastname: Tahiri
authors.forename: Chakib
authors.initials: C
authors.lastname: El Maaroufi
authors.forename: Rhizlane
authors.initials: R
authors.lastname: Berrady
authors.forename: Taoufik
authors.initials: T
authors.lastname: Harzy
authors.forename: Wafaa
authors.initials: W
authors.lastname: Bono
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D002614:Chelating Agents / Q000627:therapeutic use; D005247:Feeding Behavior; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D011073:Polyamines / Q000627:therapeutic use; D006435:Renal Dialysis / Q000009:adverse effects*; D000069603:Sevelamer; D016896:Treatment Outcome; D014511:Uremia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D002614:Chelating Agents; D011073:Polyamines; D000069603:Sevelamer