title: Hydroxyethyl starch resuscitation reduces the risk of intra-abdominal hypertension in severe acute pancreatitis.
abstract: OBJECTIVE
  This study aimed to address whether hydroxyethyl starch (HES) is beneficial for intra-abdominal pressure (IAP) in severe acute pancreatitis (SAP) in early stages.
  
  
  METHODS
  Forty-one patients with SAP were randomized to HES group (n = 20) and the Ringer's lactate (RL) group (n = 21). The groups received 6% HES 130/0.4 for 8 days and RL solution without colloid, respectively. The primary end point was the IAP. The secondary end points were fluid balance, major organ complications, the Acute Physiology and Chronic Heath Evaluation II score, and the serum levels of C-reactive protein, interleukin-6, and interleukin-8.
  
  
  RESULTS
  The characteristics of baseline data were similar in the 2 groups. In the HES group, the IAP was significantly lower in 2 to 7 days, and fewer patients received mechanical ventilation (15.0% vs 47.6%). A negative fluid balance was observed earlier in the HES group than in the RL group (2.5 ± 2.2 vs 4.0 ± 2.5 days).
  
  
  CONCLUSIONS
  Fluid resuscitation with HES in the early stages of SAP can decrease the risk of intra-abdominal hypertension and reduce the use of mechanical ventilation.
authors.affiliation: Department of Hepatobiliopancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Xiao-Jiong
authors.initials: XJ
authors.lastname: Du
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Hu
authors.forename: Qing
authors.initials: Q
authors.lastname: Xia
authors.forename: Zhong-Wen
authors.initials: ZW
authors.lastname: Huang
authors.forename: Guang-Yuan
authors.initials: GY
authors.lastname: Chen
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Jin
authors.forename: Ping
authors.initials: P
authors.lastname: Xue
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Lu
authors.forename: Neng-wen
authors.initials: NW
authors.lastname: Ke
authors.forename: Zhao-Da
authors.initials: ZD
authors.lastname: Zhang
authors.forename: Quan-Sheng
authors.initials: QS
authors.lastname: Li
mesh_terms: D000208:Acute Disease; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D059325:Intra-Abdominal Hypertension / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications* / Q000473:pathology; D010952:Plasma Substitutes / Q000627:therapeutic use; D012151:Resuscitation / Q000379:methods*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D015850:Interleukin-6; D016209:Interleukin-8; D010952:Plasma Substitutes; D002097:C-Reactive Protein