title: Impact of human immunodeficiency virus coinfection on the progression of mother-to-child transmitted hepatitis C virus infection.
abstract: Data on mother-to-child transmitted human immunodeficiency virus/hepatitis C virus (HIV/HCV) coinfection are scarce. A prospective observational study with a cohort of 70 HCV-infected children (13 of whom were HIV/HCV-coinfected; mean follow-up: 7.3 years) is presented. In our series, surrogate markers of disease progression (HCV viremia, maximum alanine aminotransferase values, and spontaneous HCV infection clearance) suggest that the evolution of liver disease in HIV/HCV-coinfected pediatric patients is more aggressive than it is in HCV-only infected children.
authors.affiliation: Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain. ton@hsjdbcn.org
authors.forename: Gemma
authors.initials: G
authors.lastname: Claret-Teruel
authors.forename: Antoni
authors.initials: A
authors.lastname: Noguera-Julian
authors.forename: Cristina
authors.initials: C
authors.lastname: Esteva
authors.forename: Carmen
authors.initials: C
authors.lastname: Muñoz-Almagro
authors.forename: Emília
authors.initials: E
authors.lastname: Sánchez
authors.forename: Rafael
authors.initials: R
authors.lastname: Jiménez
authors.forename: Clàudia
authors.initials: C
authors.lastname: Fortuny
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D060085:Coinfection / Q000821:virology; D018450:Disease Progression; D005260:Female; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000150:complications*; D016174:Hepacivirus / Q000502:physiology; D006526:Hepatitis C / Q000150:complications / Q000635:transmission*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011446:Prospective Studies; D055815:Young Adult