title: Reproducibility of broth microdilution and comparison to agar dilution for testing CB-183,315 against clinical isolates of Clostridium difficile.
abstract: This study evaluated the reproducibility and agreement of broth microdilution to agar dilution (AD) for testing CB-183,315, a novel lipopeptide antibiotic for Clostridium difficile. Reproducibility was 100% within ± one 2-fold dilution for 10 strains tested; agreement was 90-95% within one 2-fold dilution with AD for 103 clinical isolates.
authors.affiliation: R.M. Alden Research Lab, Culver City, CA 90230, USA. d.m.citron@att.net
authors.forename: Diane M
authors.initials: DM
authors.lastname: Citron
authors.forename: Ellie J C
authors.initials: EJ
authors.lastname: Goldstein
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects*; D006801:Humans; D055666:Lipopeptides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D010456:Peptides, Cyclic / Q000494:pharmacology*; D015203:Reproducibility of Results
chemical_list: D000900:Anti-Bacterial Agents; C574454:CB-183,315; D055666:Lipopeptides; D010456:Peptides, Cyclic