title: [Clinical observation of Clarithromycin combined with nasal steroid treatment for chronic rhinosinusitis].
abstract: OBJECTIVE
  To observe the clinical treatment effectiveness of Clarithromycin combined with nasal glucocorticoids for chronic rhinosinusitis (CRS).
  
  
  METHODS
  Clarithromycin was 0.25 g a day (the first two weeks was 0.25 g twice a day) and topical Triamcinolone Acetonide Acetate nasal spray was (220 microg/d) once a day. Fifty-six patients were enrolled in our research. Twenty-six patients of CRS without nasal polyps was treated for 12 to 28 weeks (average 16.62 weeks). Thirty patients of CRS with nasal polyps was treated for 12 to 33 weeks (average 20.03 weeks) after polypectomy. The patients' symptom were evaluated through Sino-Nasal Outcome Test 20 (SNOT-20) scale. Meanwhile sinus CT were evaluated by Lund-Mackey system before and after operation.
  
  
  RESULTS
  The score of CT scan was significantly decreased to 2.83 +/- 1.86 (t = 11.41, P < 0.01) in the CRS with nasal polyps group and to 2.43 +/- 1.91 (t = 12.86, P < 0.01) in the CRS without nasal polyps group after treatment. Recovery rate of CRS with nasal polyps group was 43.3% and of CRS without nasal polyps group was 50.0% with CT images. The self assessments of treatment efficiency was coincident with CT image in the two groups.
  
  
  CONCLUSIONS
  The treatment with Long term use of low dosage oral macrolide Clarithromycin combined with nasal steroid on CRS was efficacy. Polypectomy ,large dose antibiotic and steroid used in intraoperative period could significant improve the treatment efficiency of CRS with nasal polyps.
authors.affiliation: Department of Otorhinolaryngology, the Disabled Soldiers, Hospital of Guangdong Province, Guangzhou, 510260, China. entliu0503@163.com
authors.forename: Jubo
authors.initials: J
authors.lastname: Liu
authors.forename: Liya
authors.initials: L
authors.lastname: Liu
authors.forename: Xiang
authors.initials: X
authors.lastname: Lu
authors.forename: Gangyi
authors.initials: G
authors.lastname: Zhong
authors.forename: Ying
authors.initials: Y
authors.lastname: Wan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Feng
authors.forename: Xianhua
authors.initials: X
authors.lastname: Li
authors.forename: Yichun
authors.initials: Y
authors.lastname: Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D017291:Clarithromycin / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy; D012220:Rhinitis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D014222:Triamcinolone Acetonide; D017291:Clarithromycin