title: Evaluation of physical and biologic properties of the mixture of mineral trioxide aggregate and 4-META/MMA-TBB resin.
abstract: OBJECTIVE
  This study examined whether 4-methacryloxyethyl trimellitate anhydride/methylmethacrylate-tri-n-butyl borane (4-META/MMA-TBB) resin can be used with mineral trioxide aggregate (MTA) to overcome MTA's shortcomings. The biologic reactions of the mixture of MTA powder and 4-META/MMA-TBB resin (MTA/4-META) and its potential in clinical applications were also investigated.
  
  
  METHODS
  MTA powder was mixed with 4-META/MMA-TBB resin instead of water at the appropriate proportions determined by a series of studies prior to this experiment. MTA powder mixed with sterile water was used as control. The setting time, compressive strength, pH, and dye leakage of MTA/4-META and MTA were assessed by Gilmore apparatus, universal mechanical testing machine, pH meter, and methylene blue penetration method, respectively. Cytotoxicity also was evaluated by MTT assay with MC3T3-E1 cells.
  
  
  RESULTS
  The setting time of MTA/4-META was significantly lower than that of MTA: 11.2 ± 0.8 minutes versus 318 ± 56.0 minutes, respectively (P < .05). The mean compressive strength of MTA/4-META after 24 hours was significantly higher than that of MTA: 57.4 ± 11.6 MPa versus 18.7 ± 3.0 MPa, respectively (P < .05). MTA/4-META showed significantly less leakage than MTA (P < .05). The initial pHs for MTA and MTA/4-META at 2 hours were 10.73 ± 0.95 and 10.08 ± 0.13, respectively, and reached plateaus of 10.92 ± 0.31 and 10.54 ± 0.39 at 24 hours, respectively. The pH of MTA was higher than that of MTA/4-META in the entire period, but the differences were only significant up to 48 hours (P < .05). MTA and MTA/4-META both showed no cytotoxicity.
  
  
  CONCLUSIONS
  4-META/MMA-TBB resin as a mixing vehicle of MTA powder can improve the setting and handling properties of MTA and may maintain or improve its other biophysical properties.
authors.affiliation: Department of Conservative Dentistry, CHA Bundang Medical Center, CHA University, Gyeonggi-do, Korea.
authors.forename: Hyunsook
authors.initials: H
authors.lastname: Chung
authors.forename: Miri
authors.initials: M
authors.lastname: Kim
authors.forename: Hyunjung
authors.initials: H
authors.lastname: Ko
authors.forename: Wonkyung
authors.initials: W
authors.lastname: Yang
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D001896:Boron Compounds / Q000737:chemistry* / Q000494:pharmacology; D017610:Calcium Compounds / Q000737:chemistry* / Q000494:pharmacology; D002478:Cells, Cultured; D019245:Compressive Strength; D003763:Dental Leakage / Q000517:prevention & control; D003799:Dental Stress Analysis; D004338:Drug Combinations; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry* / Q000494:pharmacology; D008768:Methylmethacrylates / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects; D010087:Oxides / Q000737:chemistry* / Q000494:pharmacology; D012184:Retrograde Obturation / Q000379:methods*; D012387:Root Canal Filling Materials / Q000737:chemistry* / Q000494:pharmacology; D017640:Silicates / Q000737:chemistry* / Q000494:pharmacology; D019227:Tooth Apex
chemical_list: D017607:Aluminum Compounds; D001672:Biocompatible Materials; D001896:Boron Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D008689:Methacrylates; D008768:Methylmethacrylates; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; C049495:Super-bond