title: TP53 status and response to treatment in breast cancers.
abstract: The p53 wild-type protein plays an important role in cells as is shown by its fine regulation at different levels. Since its discovery, numerous mutations have been described. In breast cancers, p53 is mutated in almost 30% of cases, with a higher frequency in some tumor subtypes. TP53 mutation is reported to be a factor for good prognosis in some studies, while in others it is a factor for poor prognosis. The explanation for these different results could be linked to the fact that the studies were performed on different tumor types and with different therapy regimens.
authors.affiliation: Université Paris Diderot, Sorbonne Paris Cité, Laboratoire de Pathologie, Paris, France. mariannavarna@yahoo.fr
authors.forename: Mariana
authors.initials: M
authors.lastname: Varna
authors.forename: Guilhem
authors.initials: G
authors.lastname: Bousquet
authors.forename: Louis-François
authors.initials: LF
authors.lastname: Plassa
authors.forename: Philippe
authors.initials: P
authors.lastname: Bertheau
authors.forename: Anne
authors.initials: A
authors.lastname: Janin
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000628:therapy*; D005260:Female; D016158:Genes, p53; D006801:Humans; D051379:Mice; D009154:Mutation; D011379:Prognosis