title: Diurnal variability in orthostatic tachycardia: implications for the postural tachycardia syndrome.
abstract: Patients with POTS (postural tachycardia syndrome) have excessive orthostatic tachycardia (>30 beats/min) when standing from a supine position. HR (heart rate) and BP (blood pressure) are known to exhibit diurnal variability, but the role of diurnal variability in orthostatic changes of HR and BP is not known. In the present study, we tested the hypothesis that there is diurnal variation of orthostatic HR and BP in patients with POTS and healthy controls. Patients with POTS (n=54) and healthy volunteers (n=26) were admitted to the Clinical Research Center. Supine and standing (5 min) HR and BP were obtained in the evening on the day of admission and in the following morning. Overall, standing HR was significantly higher in the morning (102±3 beats/min) than in the evening (93±2 beats/min; P<0.001). Standing HR was higher in the morning in both POTS patients (108±4 beats/min in the morning compared with 100±3 beats/min in the evening; P=0.012) and controls (89±3 beats/min in the morning compared with 80±2 beats/min in the evening; P=0.005) when analysed separately. There was no diurnal variability in orthostatic BP in POTS. A greater number of subjects met the POTS HR criterion in the morning compared with the evening (P=0.008). There was significant diurnal variability in orthostatic tachycardia, with a great orthostatic tachycardia in the morning compared with the evening in both patients with POTS and healthy subjects. Given the importance of orthostatic tachycardia in diagnosing POTS, this diurnal variability should be considered in the clinic as it may affect the diagnosis of POTS.
authors.affiliation: Division of Clinical Pharmacology, Vanderbilt University School of Medicine, AA3228 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232-2195, USA.
authors.forename: Jordan A
authors.initials: JA
authors.lastname: Brewster
authors.forename: Emily M
authors.initials: EM
authors.lastname: Garland
authors.forename: Italo
authors.initials: I
authors.lastname: Biaggioni
authors.forename: Bonnie K
authors.initials: BK
authors.lastname: Black
authors.forename: John F
authors.initials: JF
authors.lastname: Ling
authors.forename: Cyndya A
authors.initials: CA
authors.lastname: Shibao
authors.forename: David
authors.initials: D
authors.lastname: Robertson
authors.forename: Satish R
authors.initials: SR
authors.lastname: Raj
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood; D054972:Postural Orthostatic Tachycardia Syndrome / Q000097:blood / Q000503:physiopathology*; D011187:Posture / Q000502:physiology*; D016683:Supine Position / Q000502:physiology; D013610:Tachycardia / Q000503:physiopathology*
chemical_list: D009638:Norepinephrine; D004837:Epinephrine