title: Enantioselective synthesis of polycyclic coumarin derivatives catalyzed by an in situ formed primary amine-imine catalyst.
abstract: A facile in situ formed primary amine-imine organocatalyst was developed in the asymmetric Michael addition of substituted 4-hydroxycoumarins to cyclic enones. A series of optically active polycyclic coumarin derivatives were obtained in high yields with excellent enantioselectivities up to 97% ee.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, PR China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhu
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Jingyu
authors.initials: J
authors.lastname: Guo
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D007097:Imines / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000588:Amines; D003374:Coumarins; D007097:Imines; C030123:coumarin