title: Detection of neuronal current MRI in human without BOLD contamination.
abstract: Controversial results regarding the detectability of neuronal current magnetic resonance imaging (ncMRI) have been reported in different studies on human subjects. In all the previous studies, the ncMRI signal was detected under a continuous and paradigm task-induced blood oxygen level dependent (BOLD) signal background. The aim of this study is to investigate the possibility of detecting ncMRI signal in human brain in the situation that task-induced BOLD background is absent or minimum. In this study, by adopting an event-related visuomotor paradigm with long interstimulus interval (=20 s), the ncMRI signal was detected when the BOLD signal fully returned to its baseline, and the potential BOLD background contamination was avoided effectively. The results showed that the visuomotor stimulation elicited BOLD activation in visual and motor cortices, but no significant ncMRI signal change (in magnitude) was detected in human brain. These experimental findings are consistent with theoretical predications.
authors.affiliation: Department of Radiology, Brain Research Imaging Center, The University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Qingfei
authors.initials: Q
authors.lastname: Luo
authors.forename: Xia
authors.initials: X
authors.lastname: Jiang
authors.forename: Jia-Hong
authors.initials: JH
authors.lastname: Gao
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D016477:Artifacts; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009474:Neurons / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity