title: [Association of adiponectin gene polymorphism with obesity in children].
abstract: OBJECTIVE
  To study the distribution characteristics of adiponectin gene +45 single nucleotide polymorphisms (SNP) in Chinese children, and to determine the role of adiponectin gene +45 polymorphisms in the pathogenesis of childhood obesity.
  
  
  METHODS
  A total of 147 Chinese obese and 118 healthy children were randomly selected and enrolled to identify adiponectin gene SNP+45 polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Plasma adiponectin levels were determined using ELISA. Waist circumference (WC), waist to hip ratio (WHR), percentage of body fat (%BF), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), serum triglycerides (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), plasma fasting insulin (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR) were measured.
  
  
  RESULTS
  The allelic frequency of adiponectin gene SNP+45 in children with obesity and healthy controls were 40.5% and 25.4%, respectively. There were significant differences in the distribution of genotypes and the allelic frequency between the two groups (P<0.05). The plasma adiponectin levels were significantly higher, in contrast, %BF, HOMA-IR, TC and LDL-C levels were significantly lower in obese children with TT genotype than those in obese children with TG or GG genotype.
  
  
  CONCLUSIONS
  The adiponectin gene SNP+45 polymorphism may be associated with pathogenesis of obesity in children. T→G variance may be associated an increased risk of childhood obesity and result in a decreased level of adiponectin.
authors.affiliation: Department of Endocrinology, Xiangya Hospital of Central South University, Changsha 410008, China. wujing0731@hotmail.com
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Wei-Jian
authors.initials: WJ
authors.lastname: Yan
authors.forename: Juan
authors.initials: J
authors.lastname: Mo
authors.forename: Hao-Bo
authors.initials: HB
authors.lastname: Yang
authors.forename: Zhao-Zhao
authors.initials: ZZ
authors.lastname: Wang
authors.forename: Min-Xiang
authors.initials: MX
authors.lastname: Lei
authors.forename: Lie-Wu
authors.initials: LW
authors.lastname: Peng
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000209:etiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D008055:Lipids