title: Recurarization after sugammadex reversal in an obese patient.
abstract: OBJECTIVE
  We report a case that involved immediate postoperative respiratory failure necessitating tracheal intubation, which was possibly related to recurarization after sugammadex reversal.
  
  
  RESULTS
  A 54-yr-old woman weighing 115-kg was scheduled for laparoscopic repair of abdominal dehiscence under general anesthesia. Muscle relaxation was induced and maintained with rocuronium (170 mg iv total dose). At the end of the 170-min procedure, two twitches were visualized after supramaximal train-of-four (TOF) stimulation at the adductor pollicis muscle, and the patient's central core temperature was 35.6°C. Sugammadex 200 mg iv (1.74 mg·kg(-1)) was administered. With the patient fully awake, a TOF ratio 0.9 was obtained five minutes later. The tracheal tube was then removed, and the patient was transferred to the postanesthesia care unit. Ten minutes later, the patient presented respiratory failure necessitating tracheal intubation and sedation with propofol. One TOF response only was visualized at the adductor pollicis muscle. Another dose of sugammadex 200 mg iv was administered. Forty-five minutes later, the patient was fully awake and her trachea was extubated after repeated measures of the TOF ratio (≥ 0.9) at the adductor pollicis muscle. The patient fully recovered without sequelae, further complication, or prolonged hospital stay.
  
  
  CONCLUSIONS
  Shortly after tracheal extubation, an obese patient experienced respiratory failure necessitating tracheal intubation and an additional dose of sugammadex. This occurred despite initial reversal of neuromuscular blockade with an appropriate dose of sugammadex 2 mg·kg(-1) iv given at two responses to TOF stimulation.
authors.affiliation: Université Paris Est Créteil, Service d'Anesthésie, Réanimation Chirurgicale, Samu94-Smur, Groupe Hospitalier et Universitaire Albert Chenevier-Henri Mondor, 51, Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil Cedex, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Le Corre
authors.forename: Salmi
authors.initials: S
authors.lastname: Nejmeddine
authors.forename: Chérif
authors.initials: C
authors.lastname: Fatahine
authors.forename: Claude
authors.initials: C
authors.lastname: Tayar
authors.forename: Jean
authors.initials: J
authors.lastname: Marty
authors.forename: Benoît
authors.initials: B
authors.lastname: Plaud
mesh_terms: D000732:Androstanols / Q000627:therapeutic use*; D000768:Anesthesia, General / Q000379:methods; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods; D010535:Laparoscopy / Q000379:methods; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000627:therapeutic use; D009765:Obesity / Q000150:complications* / Q000601:surgery; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000209:etiology; D000077123:Rocuronium; D000077122:Sugammadex; D013529:Surgical Wound Dehiscence / Q000601:surgery; D047408:gamma-Cyclodextrins / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium