title: Antioxidant and tyrosinase inhibitory constituents from a desugared sugar cane extract, a byproduct of sugar production.
abstract: Recycling agricultural resources has become an important issue worldwide promoting the economical value of agricultural production processes. Desugared sugar cane extract (DSE) from Saccharum officinarum is a byproduct obtained during sugar production. Two new neolignan glucosides, saccharnan A (1) and saccharnan B (2), together with 10 known phenolics (3-12) were isolated from DSE, and their structures were elucidated on the basis of NMR spectral analysis. Compounds 3, 4, 8, and 9 showed good activity against DPPH radical (IC(50) ≤ 51.20 μM) and compounds 3-8 and 12 exhibited strong ABTS(+) free radical scavenging activity (IC(50) ≤ 51.57 μM) compared to those of the positive controls, ascorbic acid and Trolox. Moreover, compounds 7 and 12 acted as potent tyrosinase inhibitors (IC(50) ≤ 42.59 μM) compared to the positive control arbutin. Our results highlighted the economical value of recycling DSE for the future development of natural antioxidants and/or tyrosinase inhibitors.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Chung
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Wang
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Shazly
authors.forename: Yann-Lii
authors.initials: YL
authors.lastname: Leu
authors.forename: Ming-Ching
authors.initials: MC
authors.lastname: Cheng
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Lee
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000975:Antioxidants / Q000032:analysis* / Q000494:pharmacology; D002241:Carbohydrates; D004791:Enzyme Inhibitors / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000032:analysis / Q000737:chemistry; D007220:Industrial Waste; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010636:Phenols / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry*; D059027:Recycling; D031786:Saccharum / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D002241:Carbohydrates; D004791:Enzyme Inhibitors; D005960:Glucosides; D007220:Industrial Waste; D010636:Phenols; D010936:Plant Extracts; D014442:Monophenol Monooxygenase