title: Eumycetoma caused by Diaporthe phaseolorum (Phomopsis phaseoli): a case report and a mini-review of Diaporthe/Phomopsis spp invasive infections in humans.
abstract: Diaporthe phaseolorum (syn. Phomopsis phaseoli) is a frequent fungal parasite of plants, present on all continents around the world. It has rarely been involved in human diseases. We report a case of eumycetoma with osteomyelitis of the forefoot caused by this fungus and diagnosed by molecular biology. The patient had positive HTLV-1 serology and was a farmer from French Guiana who walked barefoot. He was successfully treated with long-term oral itraconazole (400 mg/day). A review of the literature underlines the essential roles of plants and host immunosuppression in this infection and the favourable outcome with a triazole antifungal treatment.
authors.affiliation: Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana. xabierlete@yahoo.fr
authors.forename: X
authors.initials: X
authors.lastname: Iriart
authors.forename: R
authors.initials: R
authors.lastname: Binois
authors.forename: A
authors.initials: A
authors.lastname: Fior
authors.forename: D
authors.initials: D
authors.lastname: Blanchet
authors.forename: A
authors.initials: A
authors.lastname: Berry
authors.forename: S
authors.initials: S
authors.lastname: Cassaing
authors.forename: E
authors.initials: E
authors.lastname: Amazan
authors.forename: E
authors.initials: E
authors.lastname: Papot
authors.forename: B
authors.initials: B
authors.lastname: Carme
authors.forename: C
authors.initials: C
authors.lastname: Aznar
authors.forename: P
authors.initials: P
authors.lastname: Couppié
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001203:Ascomycota / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D001706:Biopsy; D005260:Female; D005528:Foot / Q000382:microbiology* / Q000473:pathology; D005616:French Guiana; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008271:Mycetoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D010019:Osteomyelitis / Q000150:complications / Q000382:microbiology; D035583:Rare Diseases / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole