title: Regulation of angiostatic chemokines driven by IL-12 and IL-27 in human tumors.
abstract: Chemokines have pleiotropic effects in regulating immunity, angiogenesis, and tumor growth. CXC and CC chemokine families members and their receptors are able to exert a proangiogenic or an antiangiogenic effect in experimental models and in human tumors. In this review article, we have summarized literature data and our studies concerning the angiostatic activity of chemokines. Their angiostatic activity may be a result of a direct effect on the biological functions of endothelial cells and/or an effect on tumor cells inhibiting their capability to stimulate new blood vessel formation. Moreover, chemokines have a pro- and antitumor effect within the tumor microenvironment by regulating immune cell infiltration and its antitumor activities. We have focused our interest on the role of IL-12 and IL-27 in solid and hematological tumors, and we have suggested and discussed their potential use as antiangiogenic agents in the treatment of such tumors.
authors.affiliation: Department of Experimental and Laboratory Medicine, G. Gaslini Institute, Genova, Italy.
authors.forename: Irma
authors.initials: I
authors.lastname: Airoldi
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D020533:Angiogenesis Inhibitors / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D019743:Chemokines, CXC / Q000276:immunology / Q000378:metabolism; D042783:Endothelial Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D006801:Humans; D018664:Interleukin-12 / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D007378:Interleukins / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D059016:Tumor Microenvironment / Q000187:drug effects / Q000276:immunology
chemical_list: D020533:Angiogenesis Inhibitors; D019743:Chemokines, CXC; D007378:Interleukins; C464565:MYDGF protein, human; D018664:Interleukin-12