title: Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms.
abstract: Dengue is a mosquito-borne viral disease of expanding geographical range and incidence. The existence of four viral serotypes and the association of prior dengue virus infection with an increased risk for more severe disease have presented significant obstacles to vaccine development. An increased understanding of the adaptive immune response to natural dengue virus infection and candidate dengue vaccines has helped to define the specific antibody and T cell responses that are associated with either protective or pathological immunity during dengue infection. Further characterization of immunological correlates of disease outcome and the validation of these findings in vaccine trials will be invaluable for developing effective dengue vaccines.
authors.affiliation: Institute for Immunology and Informatics and Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island 02903, USA. arothman.uri@gmail.com
authors.forename: Alan L
authors.initials: AL
authors.lastname: Rothman
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D003715:Dengue / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D053059:Dengue Vaccines / Q000276:immunology; D003716:Dengue Virus / Q000276:immunology*; D006801:Humans
chemical_list: D000956:Antigens, Viral; D016207:Cytokines; D053059:Dengue Vaccines