title: ¹H, ¹³C, ¹⁵N and ³¹P chemical shift assignments of a human Xist RNA A-repeat tetraloop hairpin essential for X-chromosome inactivation.
abstract: Initiation of X-chromosome inactivation in female mammals depends on the non-coding RNA Xist. We have solved the NMR structure of a 14-nucleotide hairpin with a novel AUCG tetraloop fold from a Xist A-repeat that is essential for silencing. The (1)H, (13)C, (15)N and (31)P chemical shift assignments are reported.
authors.affiliation: Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
authors.forename: Malgorzata M
authors.initials: MM
authors.lastname: Duszczyk
authors.forename: Michael
authors.initials: M
authors.lastname: Sattler
mesh_terms: D041321:Chromosomes, Human, X / Q000235:genetics*; D006801:Humans; D055029:Inverted Repeat Sequences; D019906:Nuclear Magnetic Resonance, Biomolecular; D022661:RNA, Untranslated / Q000737:chemistry* / Q000235:genetics*; D049951:X Chromosome Inactivation / Q000235:genetics*
chemical_list: D022661:RNA, Untranslated