title: Which SPM method should be used to extract hippocampal measures in early Alzheimer's disease?
abstract: OBJECTIVE
  To provide guidance regarding the most appropriate voxel-based morphometry (VBM)-derived method for assessing hippocampal atrophy in early Alzheimer's disease (AD).
  
  
  METHODS
  T1-MRI volume data were collected in 23 patients with amnestic mild cognitive impairment (aMCI) and 18 controls. Three types of data (unmodulated and 2 types of modulated MRI) and 2 extraction methods (with reference to the hippocampal peak of atrophy identified from a preliminary whole-brain analysis, or using a template region of interest-ROI-approach) were compared to the gold-standard individual ROI (ROI-i) method through 2 statistical approaches (ANOVA and Pearson's R).
  
  
  RESULTS
  First, whole-brain analyses performed on modulated data are as sensitive as the ROI-i approach in detecting aMCI patients' hippocampal atrophy. Second, values extracted from the ROI-template applied to modulated data provide measures of hippocampal volume comparable to those obtained using the ROI-i approach.
  
  
  CONCLUSIONS
  This study provides guidance on how to extract accurate hippocampal measures from VBM-derived data in early AD, as a time-saving and easy alternative to the reference ROI-i method.
authors.affiliation: Inserm-EPHE-Université de Caen/Basse-Normandie, Unité U923, GIP Cyceron, CHU Côte de Nacre, Caen, France.
authors.forename: Katell
authors.initials: K
authors.lastname: Mevel
authors.forename: Béatrice
authors.initials: B
authors.lastname: Desgranges
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Baron
authors.forename: Brigitte
authors.initials: B
authors.lastname: Landeau
authors.forename: Vincent
authors.initials: V
authors.lastname: de La Sayette
authors.forename: Fausto
authors.initials: F
authors.lastname: Viader
authors.forename: Francis
authors.initials: F
authors.lastname: Eustache
authors.forename: Gaël
authors.initials: G
authors.lastname: Chételat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001284:Atrophy; D060825:Cognitive Dysfunction / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D009929:Organ Size