title: [Methotrexate-induced changes in the concentration of antibodies to mutaded citrullinated vimentin in blood serum of patients with rheumatoid arthritis].
abstract: OBJECTIVE
  To study effects of methotrexate on the titer of antibodies to mutated citrullinated vimentin (anti-MCV) and ascertain possibility of using this marker for control of treatment results and choice of individual effective dose of the drug.
  
  
  METHODS
  A 12-month trial included 76 patients with verified rheumatoid arthritis (RA). Methotrexate per os was given in a dose 7.5-10 mg/week to 44 (57.9%) patients, 25 patients received no basic therapy. Anti-MCV (IU/ml) were detected with commercial chemicals made in Germany (ORGENTEC).
  
  
  RESULTS
  RA patients given methotrexate doses 7.5 and 10 mg/week and untreated with basic anti-inflammatory drugs showed no significant differences by basic clinical and device parameters, level of anti-MCV at primary examination and 12 months later.
  
  
  CONCLUSIONS
  Anti-MCV titer cannot be used for control of efficacy of methotrexate treatment in doses 75 and 10 mg/week, choice of individual effective doses.
authors.forename: N P
authors.initials: NP
authors.lastname: Shilkina
authors.forename: M S
authors.initials: MS
authors.lastname: Voronina
authors.forename: A A
authors.initials: AA
authors.lastname: Vinogradov
authors.forename: O L
authors.initials: OL
authors.lastname: Borisova
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood* / Q000187:drug effects / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D002956:Citrulline / Q000097:blood / Q000235:genetics / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D009154:Mutation; D014746:Vimentin / Q000097:blood / Q000235:genetics / Q000276:immunology*
chemical_list: D018501:Antirheumatic Agents; D001323:Autoantibodies; D015415:Biomarkers; D014746:Vimentin; D002956:Citrulline; D008727:Methotrexate