title: Fuzzy-based framework for diagnosis of acid-base disorders.
abstract: The main objective of this research is to develop a fuzzy-based framework for diagnosis of different acid-base disorders. There are several acid-base disorders that cause many clinical complications and their proper diagnosis is the only way for their efficient treatment. The common disorders are metabolic acidosis, metabolic alkalosis, non-anion gap acidosis, anion-gap acidosis, acute respiratory alkalosis and chronic respiratory alkalosis. The proposed fuzzy-based framework was used to diagnose all of these disorders using four parameters directly measured in blood: hydrogen-ion concentration (pH), arterial blood carbon dioxide partial pressure (paCO₂), sodium ions concentration (Na⁺) and chloride ions concentration (Cl⁻) along with 12 features extracted from the directly measured parameters. The validation results showed that the developed framework has an accuracy of 94%, an average sensitivity of 88% and a specificity of 93%. These results imply that the developed fuzzy-based framework is accurate and reliable one and can be used to help clinicians specially the non-expert ones to provide correct and rapid diagnosis of acid-base disorders.
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, Jordan University of Science and Technology, P.O. Box 3030, 22110 Irbid, Jordan.
authors.forename: Mashhour Bani
authors.initials: MB
authors.lastname: Amer
mesh_terms: D000137:Acid-Base Imbalance / Q000097:blood / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D002712:Chlorides / Q000097:blood; D019295:Computational Biology / Q000379:methods*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D017143:Fuzzy Logic; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012964:Sodium / Q000097:blood
chemical_list: D002712:Chlorides; D002245:Carbon Dioxide; D012964:Sodium