title: Endobronchial ultrasound in hilar and conventional TBNA-negative/inconclusive mediastinal lymphadenopathy.
abstract: OBJECTIVE
  Assess the diagnostic yield of real-time bronchoscopic ultrasound transbronchial needle aspiration (EBUS TBNA) in conventional TBNA-negative mediastinal lymphadenopathy and hilar lymphadenopathy.
  
  
  METHODS
  Sixty-two patients having either conventional TBNA-negative mediastinal lymphadenopathy or hilar lymphadenopathy underwent real-time EBUS TBNA.
  
  
  RESULTS
  EBUS TBNA was performed on 72 lymph nodes (mediastinal = 48; and hilar = 24). 31 of the 72 (43%) lymph node samples were positive for malignancy (29) or benign diagnosis (2), and 17 of the 72 (24%) lymph nodes were true negative at EBUS TBNA confirmed at surgery. Out of 48 mediastinal lymph nodes EBUS TBNA was diagnostic for malignancy in 19 (40%) and negative in 14 of which 12 (86%) were surgically confirmed true negative and 2 (14%) false negative. In 10 of the 24 (42%) hilar lymph nodes, EBUS TBNA was diagnostic for malignancy while 5 were true negative and 1 false negative. All false-negative lymph nodes were PET positive. Adequacy of EBUS TBNA based on positive aspiration and surgically confirmed true negative was 67% and in patients suspected for malignancy was 77%.
  
  
  CONCLUSIONS
  EBUS TBNA has a good diagnostic yield in hilar lymphadenopathy and in conventional TBNA-negative mediastinal lymphadenopathy.
authors.affiliation: Pulmonary Medicine, University Hospital Basel, Basel, Switzerland. pchhajed@uhbs.ch
authors.forename: Prashant N
authors.initials: PN
authors.lastname: Chhajed
authors.forename: Rahel
authors.initials: R
authors.lastname: Odermatt
authors.forename: Christophe
authors.initials: C
authors.lastname: von Garnier
authors.forename: Parag
authors.initials: P
authors.lastname: Chaudhari
authors.forename: Joerg D
authors.initials: JD
authors.lastname: Leuppi
authors.forename: Daiana
authors.initials: D
authors.lastname: Stolz
authors.forename: Michael
authors.initials: M
authors.lastname: Tamm
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D055745:Bronchioles / Q000000981:diagnostic imaging* / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging* / Q000473:pathology; D014463:Ultrasonography