title: Association between bipolar I disorder and the L55M and Q192R polymorphisms of the paraoxonase 1 (PON1) gene.
abstract: BACKGROUND
  The purpose of this work was to study the association between the PON1 L55M and Q192R polymorphisms and bipolar I disorder in Tunisian patients and to explore their relation to the sociodemographic, clinical and therapeutic characteristics of this disease.
  
  
  METHODS
  Our study included 109 patients with bipolar I disorder and 110 controls aged 39.4±11.8 and 37.3±9.2 years, respectively. L55M and Q192R of the PON1 gene polymorphisms were determined by multiplex polymerase chain reaction.
  
  
  RESULTS
  Significant difference was detected in the distribution of the genotype frequencies of L55M and Q192R polymorphisms (χ²=6.32, df=2, p=0.04; χ²=10.15, df=2, p=0.006 respectively) between patients and controls. We noted significant association between bipolar I disorder and QR and RR genotypes (OR 2.06, CI 95% 1.10-3.84, p=0.02; OR 1.72, CI 95% 1.07-2.75, p=0.02 respectively) and between this disease and LM and MM genotypes (OR 2.22, CI 95% 1.19-4.15, p=0.012; OR 3.04, CI 95% 1.60-5.77, p=0.01 respectively). There were no significant differences in gender, age at onset, illness episode and treatment among all genotypes. However, Q192R polymorphism was significantly associated with age and patients with RR genotype were the youngest.
  
  
  CONCLUSIONS
  Bipolar I disorder was significantly associated with L55M and Q192R polymorphisms, suggesting that these polymorphisms may play a role for development of bipolar I disorder. There was no significant association between the clinical and therapeutic characteristics of this population and these polymorphisms. Further studies are required to clarify the implication of these polymorphisms in the pathophysiology of bipolar I disorder.
authors.affiliation: Laboratory of Biochemistry-Toxicology, Monastir University Hospital, Tunisia. ezzaherasma@yahoo.fr
authors.forename: Asma
authors.initials: A
authors.lastname: Ezzaher
authors.forename: Dhouha Haj
authors.initials: DH
authors.lastname: Mouhamed
authors.forename: Anwar
authors.initials: A
authors.lastname: Mechri
authors.forename: Fadoua
authors.initials: F
authors.lastname: Neffati
authors.forename: Jihéne
authors.initials: J
authors.lastname: Rejeb
authors.forename: Asma
authors.initials: A
authors.lastname: Omezzine
authors.forename: Wahiba
authors.initials: W
authors.lastname: Douki
authors.forename: Ali
authors.initials: A
authors.lastname: Bouslama
authors.forename: Lotfi
authors.initials: L
authors.lastname: Gaha
authors.forename: Mohamed Fadhel
authors.initials: MF
authors.lastname: Najjar
mesh_terms: D000293:Adolescent; D000328:Adult; D043303:Aryldialkylphosphatase / Q000235:genetics*; D001714:Bipolar Disorder / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D043303:Aryldialkylphosphatase