title: [Seroepidemiology investigation of neutralizing antibody against enterovirus 71 among healthy people in Tianjin].
abstract: OBJECTIVE
  To investigate the latent infection caused by enterovirus 71 (EV71) among healthy people in Tianjin and to provide evidence on prevention and control hand-food and mouth diseases (HFMD).
  
  
  METHODS
  1611 sera specimens were collected from healthy people in Tianjin while EV71 antibody was detected by neutralization test, and then the results were analyzed statistically.
  
  
  RESULTS
  For determining positivity, the cut-point was set at 1:4. The positive rate was 66.79% (1076/1611) for EV71 neutralizing antibody. The lowest positive rate was 32.71% in the 0 - 5 age group while the highest rate was 76.67% in the 16 - 25 age group. Significant difference was seen in the positive rates among different age groups. The lowest positive rate (59.05%) was seen in the city areas while the highest rate (72.35%) was seen in the surrounding counties. 5.71% of the people being tested showed their neutralizing antibody as ≥ 1:256. The difference was statistically significant on positive rates among different areas. We constructed logistic regression models with the EV71 neutralizing antibody positive rate as the dependent variable and age, sex, floating population, area etc. as independent variables. There appeared statistical significances in all the independent variables.
  
  
  CONCLUSIONS
  Age seemed a risk factor for recessive infection of EV71, and the neutralizing antibody against EV71 might not be kept permanently. In order to prevent and control the HFMD, more attention should be paid to the areas where more floating population were resided.
authors.affiliation: Tianjin Center for Disease Control and Prevention, Tianjin, China. jiamengli2005@yahoo.com.cn
authors.forename: Jia-meng
authors.initials: JM
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lu
authors.initials: L
authors.lastname: Gao
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Li-kun
authors.initials: LK
authors.lastname: Lü
authors.forename: Dong-jing
authors.initials: DJ
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D029821:Enterovirus A, Human / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral