title: Dermatomyofibromas presenting in pediatric patients: clinicopathologic characteristics and differential diagnosis.
abstract: Dermatomyofibroma represents a rare benign fibroblastic/ myofibroblastic cutaneous tumor that mostly occurs in young adult women. It has been seldom reported in pediatric patients. In this analysis, the clinical, histopathological and immunohistochemical findings of 12 dermatomyofibromas occurring in patients up to 16 years of age are compared with those reported in adults. Six patients were male and six were female. Nine lesions were located on the neck, two on the back and one involved the chest. The usual presentation was as an asymptomatic plaque composed of bland spindled cells arranged in dermal fascicles that were oriented parallel to the epidermis. Immunohistochemically, the lesional cells expressed calponin in 11 cases, smooth muscle actin in six and muscle-specific actin in three. In contrast to prior reports from adults, dermatomyofibromas in pediatric patients do not show a female predilection. In addition, they are mostly located on the neck (56%), while in adults the most frequent location is the shoulder (35%). Dermatomyofibromas seem to stabilize after an initial period of enlargement. Punch biopsy and clinical follow up could be an alternative approach to the surgical excision in some cases of dermatomyofibroma, particularly in instances in which surgery might inflict cosmetic defects.
authors.affiliation: Department of Pathology, Hospital Universitario de Fuenlabrada, Madrid, Spain. jtardio.hflr@salud.madrid.org
authors.forename: Juan C
authors.initials: JC
authors.lastname: Tardío
authors.forename: Daniel
authors.initials: D
authors.lastname: Azorín
authors.forename: Almudena
authors.initials: A
authors.lastname: Hernández-Núñez
authors.forename: Ana
authors.initials: A
authors.lastname: Guzmán
authors.forename: Antonio
authors.initials: A
authors.lastname: Torrelo
authors.forename: Marisa
authors.initials: M
authors.lastname: Herráiz
authors.forename: Pablo
authors.initials: P
authors.lastname: Espinosa
authors.forename: Amalia
authors.initials: A
authors.lastname: Moreno
authors.forename: Rosario
authors.initials: R
authors.lastname: Granados
authors.forename: Isabel
authors.initials: I
authors.lastname: Colmenero
mesh_terms: D000199:Actins / Q000096:biosynthesis; D000293:Adolescent; D000328:Adult; D002135:Calcium-Binding Proteins / Q000096:biosynthesis; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008840:Microfilament Proteins / Q000096:biosynthesis; D047708:Myofibroma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000096985:Calponins
chemical_list: D000199:Actins; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins; D009363:Neoplasm Proteins; D000096985:Calponins