title: Preparation and quality control of the [sm]-samarium maltolate complex as a lanthanide mobilization product in rats.
abstract: Development of lanthanide detoxification agents and protocols is of great importance in management of overdoses. Due to safety of maltol as a detoxifying agent in metal overloads, it can be used as a lanthanide detoxifying agent. In order to demonstrate the biodistribution of final complex, [(153)Sm]-samarium maltolate was prepared using Sm-153 chloride (radiochemical purity >99.9%; ITLC and specific activity). The stability of the labeled compound was determined in the final solution up to 24h as well as the partition coefficient. Biodistribution studies of Sm-153 chloride, [(153)Sm]-samarium maltolate were carried out in wild-type rats comparing the critical organ uptakes. Comparative study for Sm(3+) cation and the labeled compound was conducted up to 48 h, demonstrating a more rapid wash out for the labeled compound. The effective and biological half lives of 2.3 h and 2.46h were calculated for the complex. The data suggest the detoxification property of maltol formulation for lanthanide overdoses.
authors.affiliation: Inorganic Chemistry Department, Faculty of Sciences, Tehran University, Tehran, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Naseri
authors.forename: Amir
authors.initials: A
authors.lastname: Hakimi
authors.forename: Amir R
authors.initials: AR
authors.lastname: Jalilian
authors.forename: Ali
authors.initials: A
authors.lastname: Nemati Kharat
authors.forename: Ali
authors.initials: A
authors.lastname: Bahrami-Samani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghannadi-Maragheh