title: The effects of iridium on the renal function of female Wistar rats.
abstract: Despite the widespread use of iridium (Ir) in catalytic converters for improved capacity for reducing carbon monoxide (CO), hydrocarbon (HC) and nitrogen oxide (NO(x)) emissions, there is a lack of studies that have assessed possible toxicological hazards of exposure to Ir. The present investigation indicates that female Wistar rats exposed to Ir in the drinking water for 90 days displayed renal toxicity based on the elevated urinary retinol binding protein (RBP) and albumin. The RBP was more sensitive to albumin, showing significant increases at 0.01 mg/L.
authors.affiliation: Institute of Occupational Medicine, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.
authors.forename: Ivo
authors.initials: I
authors.lastname: Iavicoli
authors.forename: Luca
authors.initials: L
authors.lastname: Fontana
authors.forename: Alessandro
authors.initials: A
authors.lastname: Marinaccio
authors.forename: Alessandro
authors.initials: A
authors.lastname: Alimonti
authors.forename: Anna
authors.initials: A
authors.lastname: Pino
authors.forename: Antonio
authors.initials: A
authors.lastname: Bergamaschi
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Calabrese
mesh_terms: D000419:Albuminuria / Q000139:chemically induced; D000818:Animals; D060766:Drinking Water; D004785:Environmental Pollutants / Q000633:toxicity; D005260:Female; D007495:Iridium / Q000633:toxicity* / Q000652:urine; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D012177:Retinol-Binding Proteins / Q000652:urine; D059550:Toxicity Tests, Subchronic; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D060766:Drinking Water; D004785:Environmental Pollutants; D012177:Retinol-Binding Proteins; D001613:beta 2-Microglobulin; D007495:Iridium