title: Head-mountable high speed camera for optical neural recording.
abstract: We report a head-mountable CMOS camera for recording rapid neuronal activity in freely moving rodents using fluorescent activity reporters. This small, lightweight camera is capable of detecting small changes in light intensity (0.2% ΔI/I) at 500fps. The camera has a resolution of 32×32, sensitivity of 0.62V/lxs, conversion gain of 0.52μV/e(-) and well capacity of 2.1Me(-). The camera, containing intensity offset subtraction circuitry within the imaging chip, is part of a miniaturized epi-fluorescent microscope and represents a first generation, mobile scientific-grade, physiology imaging camera.
authors.affiliation: School of Engineering and Applied Science, Yale University, New Haven, CT 06520, USA.
authors.forename: Joon Hyuk
authors.initials: JH
authors.lastname: Park
authors.forename: Jelena
authors.initials: J
authors.lastname: Platisa
authors.forename: Justus V
authors.initials: JV
authors.lastname: Verhagen
authors.forename: Shree H
authors.initials: SH
authors.lastname: Gautam
authors.forename: Ahmad
authors.initials: A
authors.lastname: Osman
authors.forename: Dongsoo
authors.initials: D
authors.lastname: Kim
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Pieribone
authors.forename: Eugenio
authors.initials: E
authors.lastname: Culurciello
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D005336:Fiber Optic Technology / Q000295:instrumentation*; D008856:Microscopy, Fluorescence / Q000295:instrumentation*; D008904:Miniaturization / Q000379:methods; D009043:Motor Activity / Q000502:physiology; D009488:Neurosciences / Q000295:instrumentation*; D009830:Olfactory Bulb / Q000166:cytology / Q000502:physiology*; D051381:Rats; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology*