title: Safety evaluation of rapid build-up schedules with IR-standardized allergen extracts for subcutaneous immunotherapy of allergic respiratory diseases.
abstract: BACKGROUND
  The conventional schedule used in specific subcutaneous immunotherapy (SCIT) is a slow treatment that often leads to poor compliance or discontinuation of treatment. These disadvantages have led to design administration schedules that shorten the build-up phase without increasing the adverse reactions rate.
  
  
  METHODS
  This report reviews the available scientific documentation of the safety profile of build-up schedules for SCIT with Alustal Rapid® (a suspension of standardized allergen extracts adsorbed on aluminum hydroxide gel for specific immunotherapy) in the treatment of IgE-mediated rhinitis, conjunctivitis and bronchial asthma to inhaled allergens.
  
  
  CONCLUSIONS
  Cluster and shortened conventional schedules may offer a safe method of SCIT for the treatment of respiratory allergy and reduce the inconvenience associated with conventional schedules by reaching the maintenance dose in less time and with fewer visits; thereby this method could reduce discontinuation rates and increase compliance.
authors.affiliation: Stallergenes Ibe´rica, Medical Department, Barcelona, Spain.
authors.forename: Laureano
authors.initials: L
authors.lastname: Fernández-Távora
authors.forename: José L
authors.initials: JL
authors.lastname: Justicia
authors.forename: Carmen
authors.initials: C
authors.lastname: Moreno
authors.forename: Ana I
authors.initials: AI
authors.lastname: Tabar
authors.forename: Carmen
authors.initials: C
authors.lastname: Vidal
mesh_terms: D000485:Allergens / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D003231:Conjunctivitis / Q000188:drug therapy* / Q000276:immunology; D004334:Drug Administration Schedule; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007279:Injections, Subcutaneous / Q000379:methods; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000485:Allergens