title: Can a systems perspective help us appreciate the biological meaning of small effects?
abstract: The study of dramatic phenotypes has been pivotal to elucidating biological mechanisms. Effectively approaching low-magnitude quantitative phenotypes, a common outcome of systematic loss-of-function studies, will be critical for understanding how individual components of cells interact to generate functioning systems.
authors.affiliation: Department of Biochemistry and Biophysics, California Institute of Quantitative Biosciences, University of California-San Francisco, CA 94158, USA. helsamad@gmail.com
authors.forename: Hana
authors.initials: H
authors.lastname: El-Samad
authors.forename: Hiten D
authors.initials: HD
authors.lastname: Madhani
mesh_terms: D003585:Cell Biology; D002477:Cells / Q000166:cytology / Q000378:metabolism*; D015509:Developmental Biology / Q000379:methods*; D006801:Humans; D010641:Phenotype; D049490:Systems Biology / Q000379:methods*