title: [The role of PPARs and their isoforms in metabolic disorders related to insulin resistance and diabetes].
abstract: PPARs play the key role in energy homeostasis, inflammation, development of insulin resistance, metabolic syndrome, therefore the special attention is spared to synthesis of the ligand PPARs (fibrates, thiazolidinediones). Three isoforms of PPARs are activated by the fatty acids and their derivatives - eukosanoides. Polymorphism of the Pro 12Ala gene PPARG2 affects the sensitiveness of tissues to insulin and the risk of the development diabetes. It is assumed that the PPAR polymorphism is related to the differential answer on pharmacotherapy that is the foundation for development of the personification of the drug application and the estimate of prognosis.
authors.forename: N A
authors.initials: NA
authors.lastname: Kravchenko
authors.forename: N V
authors.initials: NV
authors.lastname: Iarmysh
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism*; D050171:Dyslipidemias / Q000235:genetics / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology*; D008074:Lipoproteins / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists / Q000235:genetics / Q000502:physiology*; D011110:Polymorphism, Genetic; D020033:Protein Isoforms
chemical_list: D008074:Lipoproteins; D047492:Peroxisome Proliferator-Activated Receptors; D020033:Protein Isoforms