title: [Thymic hyperplasia and Graves' disease: a non-fortuitous association. case report and review of literature].
abstract: Thymus hyperplasia and Graves' disease association is not well known and is probably not incidental. We report the case of a young woman affected with Graves' disease in which a retrosternal mass was disclosed during a neck ultrasonographic-examination and confirmed by chest CT-examination. Follow-up ultrasound survey showed a decrease in the thymic mass size. Because of various antithyroid drugs allergy, a surgical procedure was performed, during which both her thyroid and thymic mass were removed. The histopathologic examination of this mass confirmed the hyperplasic nature of the thymic bulging. Ninety-one cases of thymus hyperplasia and Graves' disease association have been reported in literature, of which 20 were histologically confirmed. Among these cases 35 showed a thymic mass regression under medical treatment alone. Accordingly, surgical procedures are most frequently unnecessary in such associations because of the thymic mass decrease incurred by antithyroid drug treatment.
authors.affiliation: Service d'endocrinologie-diabétologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France. Electronic address: vdesforgesbullet@ch-versailles.fr.
authors.forename: V
authors.initials: V
authors.lastname: Desforges-Bullet
authors.affiliation: Service d'endocrinologie-diabétologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: G
authors.initials: G
authors.lastname: Petit-Aubert
authors.affiliation: Service d'endocrinologie-diabétologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: C
authors.initials: C
authors.lastname: Collet-Gaudillat
authors.affiliation: Service de chirurgie viscérale, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: R
authors.initials: R
authors.lastname: Cerceau
authors.affiliation: Service de chirurgie viscérale, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: B
authors.initials: B
authors.lastname: Fraleu-Louer
authors.affiliation: Service de médecine interne, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: R
authors.initials: R
authors.lastname: Meckenstock
authors.affiliation: Service de médecine interne, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: A
authors.initials: A
authors.lastname: Greder
authors.affiliation: Service d'imagerie médicale, hôpital privé de Parly 2, 21, rue Moxouris, 78150 Le Chesnay, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Cordoliani
authors.affiliation: Service d'endocrinologie-diabétologie, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Beressi
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000601:surgery; D006801:Humans; D013952:Thymus Hyperplasia / Q000150:complications* / Q000175:diagnosis / Q000601:surgery
chemical_list: D013956:Antithyroid Agents