title: The influence of the compounding process and testing conditions on the compressive mechanical properties of poly(D,L-lactide-co-glycolide)/α-tricalcium phosphate nanocomposites.
abstract: The enhanced biological and degradation properties of bioresorbable polymer matrix nanocomposites intended for use in orthopaedic applications have been demonstrated recently. However, at the moment there are only limited reports addressing their mechanical properties under physiological conditions, which is of central importance to the successful design of these nanocomposites. Here, we show that at room temperature in dry conditions, the incorporation of α-tricalcium phosphate nanoparticles into a matrix of poly(D,L-lactide-co-glycolide) increases the compressive strength and modulus. The values at room temperature obtained for nanocomposites compounded by a modified solvent evaporation method via attrition milling in acetone were similar to those from samples compounded by twin screw extrusion. The values for nanocomposites tested at 37 °C in phosphate buffered saline solution were significantly lower than those tested at room temperature in dry conditions, and lower still after two weeks of degradation in PBS at 37 °C. These effects can be related to hydration, degradation and interface effects in the nanocomposites.
authors.affiliation: Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge, New Museums Site, Pembroke Street, Cambridge CB2 3QZ, UK. sijw2@cam.ac.uk
authors.forename: Samuel I J
authors.initials: SI
authors.lastname: Wilberforce
authors.forename: Chris E
authors.initials: CE
authors.lastname: Finlayson
authors.forename: Serena M
authors.initials: SM
authors.lastname: Best
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Cameron
mesh_terms: D002021:Buffers; D002130:Calcium Phosphates / Q000737:chemistry*; D019245:Compressive Strength; D007101:Immersion; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D002021:Buffers; D002130:Calcium Phosphates; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C018392:tricalcium phosphate