title: Intrathecal levels of vitamin D and IgG in multiple sclerosis.
abstract: BACKGROUND
  Intrathecal synthesis of IgG is a hallmark of multiple sclerosis (MS). Vitamin D may modulate B-cell function and dampen the synthesis of IgG.
  
  
  OBJECTIVE
  To investigate the relation between vitamin D levels in cerebrospinal fluid and serum and intrathecal synthesis of IgG.
  
  
  METHODS
  25-hydroxyvitamin D (25(OH)D) and IgG were assessed in cerebrospinal fluid and serum in 40 patients with MS.
  
  
  RESULTS
  There was no significant correlation between the IgG index and 25(OH)D levels in cerebrospinal fluid or serum. The levels of 25(OH)D in cerebrospinal fluid and serum did not differ between patients with and without intrathecal synthesis of IgG. There was a non-significant trend towards a positive correlation between the concentrations of 25(OH)D and IgG in the cerebrospinal fluid, but not in serum.
  
  
  CONCLUSIONS
  Physiological variation in vitamin D does not exert a major impact on intrathecal synthesis of IgG in MS.
authors.affiliation: Department of Neurology, Akershus University Hosptital, Lørenskog, Norway. trygve.holmoy@medisin.uio.no
authors.forename: T
authors.initials: T
authors.lastname: Holmøy
authors.forename: A
authors.initials: A
authors.lastname: Lossius
authors.forename: T E
authors.initials: TE
authors.lastname: Gundersen
authors.forename: S M
authors.initials: SM
authors.lastname: Moen
authors.forename: M
authors.initials: M
authors.lastname: Castellazzi
authors.forename: E
authors.initials: E
authors.lastname: Fainardi
authors.forename: I
authors.initials: I
authors.lastname: Casetta
mesh_terms: D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000134:cerebrospinal fluid
chemical_list: D007074:Immunoglobulin G; D014807:Vitamin D; C104450:25-hydroxyvitamin D