title: Improved residual hearing preservation using peri-operative minocycline during cochlear implantation.
abstract: OBJECTIVE
  To determine whether peri-operative minocycline improves preservation of residual hearing in adult patients undergoing cochlear implantation.
  
  
  METHODS
  Retrospective age, gender matched study design.
  
  
  METHODS
  Tertiary/quaternary referral centre.
  
  
  METHODS
  Nine patients undergoing cochlear implantation who received minocycline peri-operatively and a historical control group of nine matched patients who did not receive minocycline.
  
  
  METHODS
  Minocycline 200mg orally pre-operatively and 100mg daily post-operatively for ten days.
  
  
  METHODS
  Change in residual hearing thresholds at 250 and 500 Hz.
  
  
  RESULTS
  The average loss of residual hearing at 250 Hz post-cochlear implant for those who had not received minocycline was 18.9 dB (SD 12.2) compared to 16.7 dB (SD 15.0) for those who had received peri-operative minocycline (p-value 0.77). The average loss of residual hearing at 500 Hz post-cochlear implant for those who had not received minocycline was 24.4 dB (SD 15.9) compared to 19.4 dB (SD 14.3) for those who had received minocycline (p-value 0.48). Two patients who did not receive minocycline lost all residual hearing at both 250 Hz and 500 Hz post-implantation and only one patient who had received minocycline lost all residual hearing at 500 Hz.
  
  
  CONCLUSIONS
  The neuroprotective effect of minocycline may help to preserve residual hearing post-cochlear implant. Further studies are warranted.
authors.affiliation: University of British Columbia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Thamboo
authors.forename: Tyler
authors.initials: T
authors.lastname: Mori
authors.forename: Justin
authors.initials: J
authors.lastname: Chau
authors.forename: Sipke
authors.initials: S
authors.lastname: Pijl
authors.forename: Brian D
authors.initials: BD
authors.lastname: Westerberg
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001309:Auditory Threshold / Q000187:drug effects; D019929:Cochlear Implantation / Q000379:methods*; D004334:Drug Administration Schedule; D005260:Female; D006309:Hearing / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage*; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D019990:Perioperative Care; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents; D008911:Minocycline