title: Solubility and stability of indomethacin in arginine-assisted solubilization system.
abstract: Indomethacin is a non-steroidal anti-inflammatory drug (NSAID).It is practically insoluble in water, which precludes its use in aqueous solution formulations. The effect of arginine on the solubility of indomethacin was investigated in this study. The solubility enhancement of indomethacin by the arginine was observed. Aqueous solution formulation and freeze-drying formulation using arginine as hydrotropes were developed and studied for physical and chemical stability. Freeze-drying is considered as a suitable formulation to enhance shelf life of indomethacin.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Hebei Medical University, ShiJiaZhuang, PR China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Qi
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Deying
authors.initials: D
authors.lastname: Cao
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D001120:Arginine / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D005612:Freeze Drying; D007213:Indomethacin / Q000737:chemistry*; D019999:Pharmaceutical Solutions; D011208:Powders; D012995:Solubility
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019999:Pharmaceutical Solutions; D011208:Powders; D001120:Arginine; D007213:Indomethacin