title: Total synthesis of bryostatin 7 via C-C bond-forming hydrogenation.
abstract: The marine macrolide bryostatin 7 is prepared in 20 steps (longest linear sequence) and 36 total steps with five C-C bonds formed using hydrogenative methods. This approach represents the most concise synthesis of any bryostatin reported, to date.
authors.affiliation: University of Texas at Austin, Department of Chemistry and Biochemistry, 78712, United States.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lu
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Woo
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis*; D054713:Bryostatins / Q000138:chemical synthesis*; D002013:Bryozoa / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D006865:Hydrogenation
chemical_list: D001688:Biological Products; D054713:Bryostatins; C475531:bryostatin 7