title: Teaching new dogs old tricks: membrane biophysical properties in drug delivery and resistance.
abstract: "How do drugs cross the plasma membrane?" this may seem like a trivial question. This question is often overlooked to focus primarily on the different complex macro-molecular aspects involved in drug delivery or drug resistance. However, recent studies have highlighted the theme that to be fully understood, more knowledge of the underlying biology of the most complex biological processes involved in the delivery and resistance to drugs is needed. After all, why would a drug interact with a transporter then subsequently be excluded from P-glycoprotein (P-gp) expressing drug resistant cells? What are the determinants of this transition in behavior? Full consideration of the physical biology of drug delivery has allowed a better understanding of the reasons why specific membrane proteins are upregulated or overexpressed in drug resistant cells. This, in turn, allows us to identify new targets for drug chemicals. Better yet, it increases the significance of recents patents and underlines their importance in multi drug resistance.
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, College Road, Sutton Bonington, LE12 5RD, UK.
authors.forename: Nina
authors.initials: N
authors.lastname: Milosavljevic
authors.forename: Adam
authors.initials: A
authors.lastname: Blanchard
authors.forename: Miriam L
authors.initials: ML
authors.lastname: Wahl
authors.forename: Salvador
authors.initials: S
authors.lastname: Harguindey
authors.forename: Mallorie
authors.initials: M
authors.lastname: Poet
authors.forename: Laurent
authors.initials: L
authors.lastname: Counillon
authors.forename: Cyril
authors.initials: C
authors.lastname: Rauch
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001703:Biophysics; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology*; D004285:Dogs; D016503:Drug Delivery Systems / Q000379:methods*; D018432:Drug Resistance, Multiple / Q000502:physiology*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D013499:Surface Properties; D014925:Wit and Humor as Topic
chemical_list: D000970:Antineoplastic Agents