title: [Therapeutic effect of 125I-103Pd hybrid radioactive seeds on pulmonary carcinomas in BALB/c-nu mice].
abstract: OBJECTIVE
  To prepared (125)I-(103)Pd hybrid radioactive seeds and to explore their therapeutic effect on pulmonary carcinomas.
  
  
  METHODS
  The (125)I-(103)Pd hybrid radioactive seeds were prepared by a chemical method of step-by-step coat plating. Pulmonary adenocarcinoma of GLC-82 cells and pulmonary large cell carcinoma of H460 cells were cultured in vitro and then were exposed directly to (125)I, (103)Pd and (125)I-(103)Pd seeds for 48 hours to observe the killing effects of radiation. GLC-82 and H460 tumor models were established and 20 mice chosen randomly for each model. For each tumor model, there were 4 groups (n = 5 each). Then (125)I-(103)Pd, (125)I, (103)Pd and nonradioactive seeds were implanted into the tumors. Tumor sizes and weights of mice were measured and recorded every 5 days for a 2-month observation.
  
  
  RESULTS
  The (125)I-(103)Pd hybrid radioactive seeds were prepared successfully. After a 48-hour radiation from radioactive seeds, the GLC-82 cells within one particulate around (125)I, (103)Pd or (125)I-(103)Pd seeds were inhibited so as to become swollen and transfiguring. The H460 cells around (125)I seeds showed no obvious abnormality while those within one particulate around (103)Pd or (125)I-(103)Pd seeds were much fewer. No mouse died during the observation period. The radioactive seeds could inhibit the tumors. The radiotherapeutic effects were similar in two tumor modes: (125)I-(103)Pd seeds > (103)Pd seeds ≈ (125)I seeds > non-radioactive seeds. H460 tumors grew much faster than GLC-82 tumors. Meanwhile the seeds with the same nuclide were much more effective for GLC-82 tumors than for H460 tumors.
  
  
  CONCLUSIONS
  The (125)I-(103)Pd hybrid radioactive seeds are clinically applicable due to their effective inhibitions of tumor growth.
authors.affiliation: Department of Thoracic Surgery, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Yang-hong
authors.initials: YH
authors.lastname: Peng
authors.forename: Jing-ming
authors.initials: JM
authors.lastname: Zhang
authors.forename: Nai-kang
authors.initials: NK
authors.lastname: Zhou
authors.forename: Xiao-hai
authors.initials: XH
authors.lastname: Jin
authors.forename: Da-ming
authors.initials: DM
authors.lastname: Chen
authors.forename: Hui-Bo
authors.initials: HB
authors.lastname: Gao
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000379:methods*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000532:radiotherapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010165:Palladium / Q000627:therapeutic use*
chemical_list: D007457:Iodine Radioisotopes; D010165:Palladium