title: Dynamic nanoplatforms in biosensor and membrane constitutional systems.
abstract: Molecular recognition in biological systems occurs mainly at interfacial environments such as membrane surfaces, enzyme active sites, or the interior of the DNA double helix. At the cell membrane surface, carbohydrate-protein recognition principles apply to a range of specific non-covalent interactions including immune response, cell proliferation, adhesion and death, cell-cell interaction and communication. Protein-protein recognition meanwhile accounts for signalling processes and ion channel structure. In this chapter we aim to describe such constitutional dynamic interfaces for biosensing and membrane transport applications. Constitutionally adaptive interfaces may mimic the recognition capabilities intrinsic to natural recognition processes. We present some recent examples of 2D and 3D constructed sensors and membranes of this type and describe their sensing and transport capabilities.
authors.affiliation: Institut Européen des Membranes - ENSCM-UMII-CNRS 5635, Place Eugène Bataillon, Montpellier, France.
authors.forename: Eugene
authors.initials: E
authors.lastname: Mahon
authors.forename: Teodor
authors.initials: T
authors.lastname: Aastrup
authors.forename: Mihail
authors.initials: M
authors.lastname: Barboiu
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D008051:Lipid Bilayers / Q000737:chemistry; D026901:Membrane Transport Proteins / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011791:Quartz / Q000737:chemistry; D020349:Surface Plasmon Resonance; D014893:Weightlessness
chemical_list: D008051:Lipid Bilayers; D026901:Membrane Transport Proteins; D011791:Quartz