title: mRNA trafficking and local translation: the Yin and Yang of regulating mRNA localization in neurons.
abstract: Localized translation and the requisite trafficking of the mRNA template play significant roles in the nervous system including the establishment of dendrites and axons, axon path-finding, and synaptic plasticity. We provide a brief review on the regulation of localizing mRNA in mammalian neurons through critical post-translational modifications of the factors involved. These examples highlight the relationship between mRNA trafficking and the translational regulation of trafficked mRNAs and provide insight into how extracellular signals target these events during signal transduction.
authors.affiliation: Program in Neuroscience, Stony Brook University, NY 11794, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Sinnamon
authors.forename: Kevin
authors.initials: K
authors.lastname: Czaplinski
mesh_terms: D000818:Animals; D001692:Biological Transport; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D011485:Protein Binding; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism
chemical_list: D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C439768:hnRNP A2