title: Plasma fatty acids profile and estimated elongase and desaturases activities in Tunisian patients with the metabolic syndrome.
abstract: This study aimed to determine plasma fatty acids pattern and to estimate desaturases activities in Tunisian subjects with metabolic syndrome (MetS). A total of 1975 adults were randomly selected from the Great Tunis region (Tunisia). MetS was defined according to the International Diabetes Federation criteria. Saturated and monounsaturated fatty acids levels and delta 9 desaturase activity were increased, but polyunsaturated fatty acids (PUFA) levels and delta 5 desaturase activity were decreased in patients with MetS. Using multivariate analysis, MetS was found inversely associated with PUFA; compared to first quartile, multi-adjusted odd ratios (95% confidence interval) of MetS were 0.80 (0.54-1.17), 0.47 (0.27-0.81) and 0.32 (0.15-0.68) for second, third and fourth quartiles of PUFA, respectively. Altered fatty acids pattern in MetS is likely related to both dietary and metabolic changes.
authors.affiliation: UR05/08-08 and LR99ES11, Department of Biochemistry, Rabta Hospital and Faculty of Medicine of Tunis, El Manar University, Tunis, Tunisia.
authors.forename: M M
authors.initials: MM
authors.lastname: Sethom
authors.forename: S
authors.initials: S
authors.lastname: Fares
authors.forename: M
authors.initials: M
authors.lastname: Feki
authors.forename: S
authors.initials: S
authors.lastname: Hadj-Taieb
authors.forename: M
authors.initials: M
authors.lastname: Elasmi
authors.forename: S
authors.initials: S
authors.lastname: Omar
authors.forename: H
authors.initials: H
authors.lastname: Sanhaji
authors.forename: R
authors.initials: R
authors.lastname: Jemaa
authors.forename: N
authors.initials: N
authors.lastname: Kaabachi
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism*; D000328:Adult; D000368:Aged; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D000081031:Fatty Acid Elongases; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000201:enzymology / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D014416:Tunisia / Q000453:epidemiology
chemical_list: D005227:Fatty Acids; D044943:Fatty Acid Desaturases; D000123:Acetyltransferases; D000081031:Fatty Acid Elongases