title: Necroptosis: biochemical, physiological and pathological aspects.
abstract: Programmed cell death is a key component of tissue homeostasis, normal development and wide variety of diseases. Conventional view refers to programmed cell death form as caspase-mediated apoptosis while necrosis is considered as an accidental and unwanted cell demise, carried out in a non-regulated manner and caused by extreme conditions. However, accumulating evidences indicate that necrotic cell death can also be a regulated process. The term necroptosis has been introduced to describe a cell death receptor-induced, caspase-independent, highly regulated type of programmed cell death process with morphological resemblance of necrosis. Necroptosis recently has been found to contribute to a wide range of pathologic cell death forms including ischemic brain injury, neurodegenerative diseases and viral infection, therefore a better understanding of the necroptotic signaling machinery has clinical relevance.
authors.affiliation: Department of Pathogenetics, National Institute of Oncology, Ráth György street 7-9, Budapest H-1122, Hungary. dunaizs@oncol.hu
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Dunai
authors.forename: Pal I
authors.initials: PI
authors.lastname: Bauer
authors.forename: Rudolf
authors.initials: R
authors.lastname: Mihalik
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D006801:Humans; D009336:Necrosis / Q000473:pathology*; D053218:Receptors, Death Domain / Q000378:metabolism; D015398:Signal Transduction; D014777:Virus Diseases / Q000473:pathology
chemical_list: D053218:Receptors, Death Domain; D020169:Caspases