title: [Procedural sedation with propofol in non-painful interventions in children].
abstract: Propofol is the sedative of choice in our hospital for all procedural sedations in children older than 3 months. Data were collected from all patients who underwent PSA with propofol in the period from November 2007 to December 2009. The procedure was performed by a paediatrician experienced in airway management, sedation and paediatric IC, and a specialized nurse. Patient characteristics, American Society of Anesthesiologists (ASA) classification, vital parameters and propofol dosage were registered on specially designed forms. Patient data were analyzed and compared with data from a non-matched historical cohort of patients who in the past had undergone PSA with chloral hydrate.
  
  
  RESULTS
  204 procedural sedations with intravenous propofol were performed in 196 patients. The mean cumulative induction dose was 3.39 mg/kg (SD: 1.34) and the mean maintenance dose was 4.05 mg/kg/h (SD: 2.23). The success rate was 99.5%, compared to 88.6% in the cohort that had received PSA with chloral hydrate. 1 procedure was aborted because of desaturation due to an obstructed airway, for which a jaw thrust was performed. No complications were observed in 199 procedures (97.5%). In 4 procedures a mild and transient desaturation (85-89%) occurred.
  
  
  CONCLUSIONS
  The results suggest that propofol can be used safely and is effective for procedural sedation in selected children, provided that PSA is performed by experienced and trained staff.
authors.affiliation: Máxima Medisch Centrum, afd. Kindergeneeskunde en Neonatologie, Veldhoven, the Netherlands.
authors.forename: Christine J P
authors.initials: CJ
authors.lastname: Bruijnen
authors.forename: Feico J J
authors.initials: FJ
authors.lastname: Halbertsma
authors.forename: Thilo
authors.initials: T
authors.lastname: Mohns
authors.forename: Frank
authors.initials: F
authors.lastname: van Ooyen
authors.forename: Koen P
authors.initials: KP
authors.lastname: Dijkman
mesh_terms: D000293:Adolescent; D001007:Anxiety / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D003243:Consciousness / Q000187:drug effects; D003955:Diagnostic Tests, Routine / Q000379:methods / Q000523:psychology; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007223:Infant; D008297:Male; D010146:Pain / Q000517:prevention & control*; D015742:Propofol / Q000008:administration & dosage*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol