title: The effects of L-arginine on liver damage in experimental acute cholestasis an immunohistochemical study.
abstract: Obstructive jaundice damages critical functions in the liver. Nitric oxide modulation would influence liver damage induced by biliary obstruction, and little is known about it Acute cholestasis was induced by bile duct ligation (BDL) in two groups of male Sprague-Dawley rats. L-Arginine or serum physiologic was administered to treatment and control group. Histopathological and immunohistochemical iNOS expression was investigated in hepatic tissue. Plasma enzyme activities were increased in acute cholestasis, and that L-arginine treatment partially but significantly prevented the elevation of these markers of liver damage (P <  .05). Also histopathology scoring showed that the liver injury was prevented and immunohistochemical iNOS activity was increased significantly in L-arginine group (P <  .05). This study shows that, after 7 days of biliary obstruction, liver damage is well established and exogenous L-arginine treatment partially but significantly prevented the liver injury in acute cholestasis.
authors.affiliation: Department of General Surgery, Manisa State Hospital, Manisa, 35630 İzmir, Turkey.
authors.forename: Yucel
authors.initials: Y
authors.lastname: Ozsoy
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozsoy
authors.forename: Teoman
authors.initials: T
authors.lastname: Coskun
authors.forename: Kaya
authors.initials: K
authors.lastname: Yavuz
authors.forename: Kemal
authors.initials: K
authors.lastname: Ozbilgin
authors.forename: Kemal
authors.initials: K
authors.lastname: Namlı
authors.forename: Ahmet
authors.initials: A
authors.lastname: Var
authors.forename: Beyhan
authors.initials: B
authors.lastname: Ozyurt