title: SNPing at the Epidermal Barrier.
abstract: Filaggrin variants are well-established risk factors for atopic eczema (AE). Recent studies suggest additional epidermal differentiation complex (EDC) gene associations with AE. In this issue, Marenholz and colleagues confirm this prediction and show that a small proline-rich protein 3 (SPRR3) variant confers susceptibility to AE. This finding suggests that further genetic and functional characterization of SPRR3 should be performed in patients with AE.
authors.affiliation: Centre for Cutaneous Research, The Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK. d.p.kelsell@qmul.ac.uk
authors.forename: David P
authors.initials: DP
authors.lastname: Kelsell
authors.forename: Carolyn
authors.initials: C
authors.lastname: Byrne
mesh_terms: D055233:Cornified Envelope Proline-Rich Proteins / Q000235:genetics*; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D004817:Epidermis / Q000502:physiology*; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D012307:Risk Factors
chemical_list: D055233:Cornified Envelope Proline-Rich Proteins; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; C112254:SPRR3 protein, human