title: The in vivo anthelmintic efficacy of some Verbascum species growing in Turkey.
abstract: Verbascum L. (Scrophulariaceae) species are used for desiccating wounds and as a fish poison in Anatolia as well as for diarrhea and dysentery of animals in several countries. To further evaluate their activity, methanolic extracts obtained from 13 Verbascum species growing in Turkey, including V. chionophyllum Hub.-Mor., V. cilicicum Boiss., V. dudleyanum (Hub.-Mor.) Hub.-Mor., V. lasianthum Boiss., V. latisepalum Hub.-Mor., V. mucronatum Lam., V. olympicum Boiss., V. pterocalycinum var. mutense Hub.-Mor., V. pycnostachyum Boiss. & Heldr., V. salviifolium Boiss., V. splendidum Boiss., V. stachydifolium Boiss. & Heldr. and V. uschackense (Murb.) Hub.-Mor. were evaluated for their in vivo anthelmintic activity. The extracts from V. lasianthum, V. latisepalum, V. mucronatum and V. salviifolum showed the highest inhibitory rates against Aspiculuris tetraptera at 100mg/kg in mice. Additionally, extracts from V. dudleyanum and V. pterocalycinum var. mutense were found generally highly effective. The remaining species did not show any activity. Results of the present study support the utilization of these plant species employed in Turkish folk medicine.
authors.affiliation: Department of Parasitology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar 03200, Turkey. esmakozan@aku.edu.tr
authors.forename: Esma
authors.initials: E
authors.lastname: Kozan
authors.forename: Irem Tatlı
authors.initials: IT
authors.lastname: Çankaya
authors.forename: Cigdem
authors.initials: C
authors.lastname: Kahraman
authors.forename: Esra Küpeli
authors.initials: EK
authors.lastname: Akkol
authors.forename: Zeliha
authors.initials: Z
authors.lastname: Akdemir
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D035264:Flowers / Q000737:chemistry; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D010123:Oxyuriasis / Q000188:drug therapy*; D010124:Oxyuroidea / Q000187:drug effects*; D010270:Parasite Egg Count; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D014421:Turkey; D032265:Verbascum / Q000737:chemistry* / Q000145:classification
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts