title: Clinical characteristics of keratitis due to Colletotrichum gloeosporioides.
abstract: OBJECTIVE
  To determine the characteristics of the keratitis due to Colletotrichum gloeosporioides.
  
  
  METHODS
  The medical records of 3 cases of fungal keratitis caused by C. gloeosporioides were reviewed to determine the clinical characteristics. The minimal inhibitory concentrations of different antifungal drugs for all 3 isolates were determined. All 3 isolates were grown on Sabouraud dextrose agar at 25°C, 35°C, and 37°C to determine the temperature-sensitive growth.
  
  
  RESULTS
  All 3 patients lived in the southwestern part of Japan and had an ocular trauma involving organic materials. The infectious foci were localized in the anterior stroma, and they did not extend deep into the stroma in all cases. The keratitis was treated with antifungal medications including topical voriconazole and natamycin eye ointment, and was resolved in 2-3 weeks. All of the isolated strains grew well at 25°C but poorly at 35°C and 37°C. All isolated strains had similar drug-sensitivity profiles; they were sensitive to amphotericin B, itraconazole, miconazole, micafungin, and voriconazole, and relatively resistant to flucytosine, fluconazole, and natamycin.
  
  
  CONCLUSIONS
  All 3 cases of C. gloeosporioides keratitis had similar clinical features. The similarities in the drug-sensitivity profiles should be helpful in treating C. gloeosporioides keratitis.
authors.affiliation: Department of Ophthalmology and Regenerative Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. shiraia@m.ehime-u.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shiraishi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Araki-Sasaki
authors.forename: Arisa
authors.initials: A
authors.lastname: Mitani
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Miyamoto
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sunada
authors.forename: Akiko
authors.initials: A
authors.lastname: Ueda
authors.forename: Seishi
authors.initials: S
authors.lastname: Asari
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zheng
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hara
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ohashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology*; D020231:Colletotrichum / Q000302:isolation & purification*; D026141:Drug Resistance, Multiple, Fungal; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D007564:Japan; D007634:Keratitis / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D013696:Temperature; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents