title: Clinical functional MRI of sensorimotor cortex using passive motor and sensory stimulation at 3 Tesla.
abstract: OBJECTIVE
  To establish a passive motor paradigm for clinical functional MRI (fMRI) that could be beneficial for patients with motor or attention deficits who are not able to perform active motor tasks.
  
  
  METHODS
  A novel standardized sensorimotor fMRI protocol was applied in 16 healthy volunteers at 3 Tesla (T) using active and passive motor tasks as well as sensory stimulation of hands and feet. Data analysis was carried out individually using a dynamic thresholding routine.
  
  
  RESULTS
  Active motor tasks yielded time efficient and robust blood-oxygen-level-dependent (BOLD) signals in primary motor cortex. Noteworthy, it was possible to achieve equal activation levels within identical anatomical localization for passive and active motor tasks with these paradigms.
  
  
  CONCLUSIONS
  Patients unable to perform active movements can benefit from paradigms with passive motor and sensory stimulation. Therefore, we recommend these paradigms for functional somatotopic mapping of the central region at 3T in clinical routine.
authors.affiliation: Department of Neuroradiology, University of Heidelberg Medical School, Heidelberg, Germany. mblatow@uhbs.ch
authors.forename: Maria
authors.initials: M
authors.lastname: Blatow
authors.forename: Julia
authors.initials: J
authors.lastname: Reinhardt
authors.forename: Katharina
authors.initials: K
authors.lastname: Riffel
authors.forename: Ernst
authors.initials: E
authors.lastname: Nennig
authors.forename: Martina
authors.initials: M
authors.lastname: Wengenroth
authors.forename: Christoph
authors.initials: C
authors.lastname: Stippich
mesh_terms: D000328:Adult; D003198:Computer Simulation; D005260:Female; D005528:Foot / Q000473:pathology; D006225:Hand / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009038:Motion; D009044:Motor Cortex / Q000473:pathology*; D010100:Oxygen / Q000378:metabolism; D014110:Touch
chemical_list: D010100:Oxygen