title: Genetic factors associated with age-related macular degeneration.
abstract: Age-related macular degeneration (AMD) is a complex, multifactorial disease associated with environmental and genetic factors. This review emphasizes the clinical impact of the major genetic factors mainly located in the complement factor H gene and on the 10q26 locus, and their current and future implications for the management of AMD.
authors.affiliation: Department of Ophthalmology, Hôpital Intercommunal de Créteil, University of Paris XII, Créteil, France. nicolas.leveziel@chicreteil.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Leveziel
authors.forename: Julien
authors.initials: J
authors.lastname: Tilleul
authors.forename: Nathalie
authors.initials: N
authors.lastname: Puche
authors.forename: Jennyfer
authors.initials: J
authors.lastname: Zerbib
authors.forename: Franck
authors.initials: F
authors.lastname: Laloum
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.forename: Eric H
authors.initials: EH
authors.lastname: Souied
mesh_terms: D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D017242:Complement Factor H / Q000235:genetics; D000074289:High-Temperature Requirement A Serine Peptidase 1; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D011506:Proteins / Q000235:genetics; D012697:Serine Endopeptidases / Q000235:genetics
chemical_list: C514392:ARMS2 protein, human; C493495:CFH protein, human; D011506:Proteins; D017242:Complement Factor H; D000074289:High-Temperature Requirement A Serine Peptidase 1; C474012:HTRA1 protein, human; D012697:Serine Endopeptidases