title: Different chronic ethanol exposure regimens in adolescent and adult male rats: effects on tolerance to ethanol-induced motor impairment.
abstract: Findings are mixed regarding the expression of tolerance after repeated ethanol exposure, perhaps in part due to dose/frequency variations in exposure regimens. The present study compared age-related differences in tolerance development following 10 days of 1g/kg twice daily, 2g/kg once daily, or intermittent 4g/kg ethanol exposure regimens. To measure expression of chronic tolerance and acute tolerance, ethanol-induced motor impairment was assessed on day 12, with functionally equivalent ethanol doses administered across age (2g/kg - adolescents; 1.5g/kg - adults). Subsequent challenge doses resulted in lower brain ethanol concentrations in both age groups as a function of the chronic ethanol regimens. Expected age-related differences emerged in acute tolerance expression in non-manipulated animals, with adolescents, but not adults showing acute tolerance. Regimens sufficient to induce alterations in ethanol metabolism did not result in chronic functional tolerance at either age, although chronic injections were sufficient to induce acute tolerance in adults.
authors.affiliation: Center for Development and Behavioral Neuroscience, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States.
authors.forename: Margaret
authors.initials: M
authors.lastname: Broadwater
authors.forename: Elena I
authors.initials: EI
authors.lastname: Varlinskaya
authors.forename: Linda P
authors.initials: LP
authors.lastname: Spear
mesh_terms: D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004185:Disability Evaluation; D004334:Drug Administration Schedule; D004361:Drug Tolerance / Q000502:physiology*; D000431:Ethanol / Q000009:adverse effects* / Q000493:pharmacokinetics; D005260:Female; D008297:Male; D009069:Movement Disorders / Q000209:etiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol