title: [Features of immunohistochemical markers expression in cervical epithelium under thyroid dysfunction].
abstract: The purpose of the investigation was to study the morphological variants and molecular markers features of the epithelial component of cervical mucosa under thyroid dysfunction. The study groups were: group A: 180 patients operated by colloidal goiter with verified hypothyreosis treated by L-thyroxin; group B: 168 patients with similar diagnosis without replacement therapy during last 3 years; control group:150 patients with euthyreosis. Mono- and polyclonal antibodies to TSH, EGFR and VEGF were used as primary antibodies. The pathological foci in cervical mucosa displayed the following types of epithelial changes: the epithelium in proliferation stage; epithelial hyperplasia without atypia; atrophic epithelium.; The data were shown an increased expression of TSH, EGFR and VEGF which increased from proliferation to hyperplasia without atypia, also adenomyosis foci was more frequent in group without replacement therapy by L-thyroxin (group B), than in group A with hypothyreosis treated by hormone and in control group - euthyreosis. The foci of AM were characterized by the molecular atypia of TSH and growth factors EGFR and VEGF which indicate on the biological progression of cervical mucosa changes under hypothyreosis.
authors.forename: M V
authors.initials: MV
authors.lastname: Beruchashvili
authors.forename: Z G
authors.initials: ZG
authors.lastname: Tsagareli
authors.forename: L E
authors.initials: LE
authors.lastname: Gogiashvili
authors.forename: T I
authors.initials: TI
authors.lastname: Kvachadze
authors.forename: E D
authors.initials: ED
authors.lastname: Datunashvili
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002584:Cervix Uteri / Q000378:metabolism* / Q000473:pathology*; D004848:Epithelium / Q000378:metabolism* / Q000473:pathology*; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D007150:Immunohistochemistry; D008875:Middle Aged; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000627:therapeutic use; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D015415:Biomarkers; D013963:Thyroid Hormones; D042461:Vascular Endothelial Growth Factor A; C512478:EGFR protein, human; D066246:ErbB Receptors; D013974:Thyroxine