title: Spectroscopic and mycological studies of Co(II), Ni(II) and Cu(II) complexes with 4-aminoantipyrine derivative.
abstract: Complexes of the type [M(L)X(2)], where M = Co(II), Ni(II) and Cu(II), have been synthesized with novel NO-donor Schiff's base ligand, 1,4-diformylpiperazine bis(4-imino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) which is obtained by the acid catalyzed condensation of 1,4-diformylpiperazine with 4-aminoantipyrine. The elemental analyses, molar conductance measurements, magnetic susceptibility measurements, IR, UV, NMR, mass and EPR studies of the compounds led to the conclusion that the ligand acts as tetradentate chelate. The Schiff's base ligand forms hexacoordinated complexes having octahedral geometry for Ni(II) and tetragonal geometry for Co(II) and Cu(II) complexes. The mycological studies of the compounds were examined against the several opportunistic pathogens, i.e., Alternaria brassicae, Aspergillus niger and Fusarium oxysporum. The Cu(II) complexes were found to have most fungicidal behavior.
authors.affiliation: Department of Chemistry, Ramjas College, University of Delhi, University Enclave, Delhi 110007, India. sharmaamitk@yahoo.co.in
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Sharma
authors.forename: Sulekh
authors.initials: S
authors.lastname: Chandra
mesh_terms: D000675:Ampyrone / Q000031:analogs & derivatives* / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013057:Spectrum Analysis
chemical_list: D000935:Antifungal Agents; D056831:Coordination Complexes; D012545:Schiff Bases; D000675:Ampyrone; D003035:Cobalt; D003300:Copper; D009532:Nickel