title: Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand.
abstract: Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV. TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development.
authors.affiliation: INSERM U1052, 151 Cours Albert Thomas, 69003 Lyon, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Galy
authors.forename: Isabelle
authors.initials: I
authors.lastname: Chemin
authors.forename: Emilie
authors.initials: E
authors.lastname: Le Roux
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Villar
authors.forename: Florence
authors.initials: F
authors.lastname: Le Calvez-Kelm
authors.forename: Myriam
authors.initials: M
authors.lastname: Lereau
authors.forename: Doriane
authors.initials: D
authors.lastname: Gouas
authors.forename: Beatriz
authors.initials: B
authors.lastname: Vieco
authors.forename: Iris
authors.initials: I
authors.lastname: Suarez
authors.forename: Maria-Cristina
authors.initials: MC
authors.lastname: Navas
authors.forename: Michèle
authors.initials: M
authors.lastname: Chevallier
authors.forename: Helene
authors.initials: H
authors.lastname: Norder
authors.forename: Petcharin
authors.initials: P
authors.lastname: Srivatanakul
authors.forename: Anant
authors.initials: A
authors.lastname: Karalak
authors.forename: Suleeporn
authors.initials: S
authors.lastname: Sangrajrang
authors.forename: Christian
authors.initials: C
authors.lastname: Trépo
authors.forename: Pierre
authors.initials: P
authors.lastname: Hainaut