title: Comparison of the acute alterations in serum bone turnover markers and bone mineral density among women with surgical menopause.
abstract: OBJECTIVE
  To determine the effect of a sudden decrease in estrogen levels via bilateral oophorectomy on serum turnover markers and to examine their correlation with bone mineral density (BMD).
  
  
  METHODS
  This study included 51 women who had regular menses preoperatively and underwent bilateral oophorectomy for benign reasons. These women did not have any systemic disease or drug use that would influence bone metabolism. For each woman, spine and femur BMD were measured preoperatively and sixth months after surgery. Serum C-terminal telopeptide (CTX) and bone alkaline phosphatase (BAP) were measured preoperatively and at the first and sixth months after surgery. Correlations between bone turnover markers and BMD were pre- and post-operatively analyzed.
  
  
  RESULTS
  The mean serum CTX and BAP concentrations at the first and sixth postoperative months were significantly higher compared to the preoperative measurements (p=0.001). Spine BMD values at the sixth postoperative month was significantly lower compared to preoperative period (p=0.0001). There was a significant negative correlation between spine BMD values and BAP levels both in the preoperative period and at the sixth postoperative month (r=-0.407, p=0.001), whereas a significant positive correlation between serum CTX and BAP was noted at this time periods (r=0.615, p<0.001).
  
  
  CONCLUSIONS
  The results of this study showed that serum BAP and CTX levels rapidly increase in women after bilateral oophorectomy. Therefore, these markers (especially BAP) could be useful in the evaluation of osteoporosis risk in the early period of surgical menopause.
authors.affiliation: Istanbul Training and Research Hospital, Department of Gynecology and Obstetrics, Istanbul, Turkey.
authors.forename: Sengul
authors.initials: S
authors.lastname: Bahar
authors.forename: Remzi
authors.initials: R
authors.lastname: Abali
authors.forename: Savas
authors.initials: S
authors.lastname: Guzel
authors.forename: Serpil
authors.initials: S
authors.lastname: Bozkurt
authors.forename: Eda Celik
authors.initials: EC
authors.lastname: Guzel
authors.forename: Hale
authors.initials: H
authors.lastname: Aral
authors.forename: Ahmet Birtan
authors.initials: AB
authors.lastname: Boran
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D024042:Collagen Type I / Q000097:blood; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects; D008594:Menopause, Premature / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D010052:Ovariectomy / Q000009:adverse effects; D010455:Peptides / Q000097:blood; D012306:Risk; D013131:Spine / Q000000981:diagnostic imaging; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D000469:Alkaline Phosphatase