title: Etiologic factors in sialolithiasis.
abstract: OBJECTIVE
  The purpose of this study was to investigate etiologic factors for sialolithiasis in a population of patients from the United States.
  
  
  METHODS
  Retrospective, cohort study.
  
  
  METHODS
  Tertiary university.
  
  
  METHODS
  Charts for all patients diagnosed with sialolithiasis between January 2001 and February 2010 were retrospectively reviewed. Demographic factors, smoking history, comorbid medical conditions, and medication history were recorded. Statistical analyses were then performed on the collected data. Population prevalences of smoking, diuretic usage, cholelithiasis, and nephrolithiasis were obtained through literature review.
  
  
  RESULTS
  A total of 153 patients with sialolithiasis were identified. Of these patients, 125 (82%) had submandibular sialolithiasis, and 28 (18%) had parotid sialolithiasis. Positive smoking histories were present in 67 individuals (44%). Both the current rate of smoking and the rate of a history of smoking were higher in our cohort when compared with the general population, although the differences did not reach statistical significance. Smoking history did not correlate with the size of the primary sialolith. Diuretic usage in the cohort was observed at a rate of 20%, higher than reported population rates of diuretic use of 8.7%. The prevalences of cholelithiasis and nephrolithiasis were not different from observed population rates.
  
  
  CONCLUSIONS
  Sialolithiasis is an uncommon condition of unclear etiology. This study represents an initial attempt to quantify the prevalence of smoking and diuretic therapy in a population of patients with sialolithiasis.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA 94115, USA. khuoh@ohns.ucsf.edu
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Huoh
authors.forename: David W
authors.initials: DW
authors.lastname: Eisele
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004232:Diuretics / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D035583:Rare Diseases; D012189:Retrospective Studies; D012307:Risk Factors; D015494:Salivary Gland Calculi / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D012720:Severity of Illness Index; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004232:Diuretics