title: Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis.
abstract: Human urine contains a large number of proteins and peptides (the urinary proteome). Global analysis of the human urinary proteome is important for understanding urinary tract diseases. Bladder cancer is the most common urological cancer with higher incidence rates in endemic areas of Blackfoot disease (BFD) in southern Taiwan. The aim of this study was to use the proteomic approach to establish urinary protein biomarkers of bladder cancer. ADAM28, identified by proteomic approaches and confirmed by Western blotting, showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer.
authors.affiliation: Department of Chemical and Material Engineering, National Yulin University of Science and Technology, Taiwan.
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Yang
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Chu
authors.forename: Sharon Chia-Ju
authors.initials: SC
authors.lastname: Chen
authors.forename: Tze-Wen
authors.initials: TW
authors.lastname: Chung
authors.forename: Wen-Cheng
authors.initials: WC
authors.lastname: Chen
authors.forename: Lia-Beng
authors.initials: LB
authors.lastname: Tan
authors.forename: Wei-Chih
authors.initials: WC
authors.lastname: Kan
authors.forename: Hsien-Yi
authors.initials: HY
authors.lastname: Wang
authors.forename: Shih-Bin
authors.initials: SB
authors.lastname: Su
authors.forename: Yu-Chang
authors.initials: YC
authors.lastname: Tyan
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism* / Q000652:urine; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D001151:Arsenic / Q000652:urine; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015153:Blotting, Western; D002295:Carcinoma, Transitional Cell / Q000378:metabolism / Q000473:pathology* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020543:Proteome / Q000378:metabolism; D040901:Proteomics; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000652:urine
chemical_list: D014408:Biomarkers, Tumor; D020543:Proteome; D051722:ADAM Proteins; C410224:ADAM28 protein, human; D001151:Arsenic