title: Hyper-frequency viscoelastic spectroscopy of biomaterials.
abstract: With the emergence of new biomaterials and elastography imaging techniques, there is a need for innovative instruments dedicated to viscoelasticity measurements. In this work, we introduce a novel hyper-frequency viscoelastic spectroscopy (HFVS) technique dedicated to characterize soft media subjected to mid-to-very-high frequency stress ranges (or, equivalently, to probe short-to-very-short relaxation times). HFVS, which has been implemented in an analytical instrument performing non-contact measurements in less than 1 s between 10 and 1000 Hz, is a suitable tool to study viscoelasticity for bio-applications. In this context, HFVS has been compared to classical oscillatory rheometry on several classes of soft materials currently encountered in tissue repair, bioengineering and elastography imaging on a frequency range between 10 and 100 Hz. After having demonstrated the good correspondence between HFVS and rheometry, this study has been completed by exploring the sensitivity of HFVS to physicochemically induced variations of viscoelasticity. HFVS opens promising perspectives in the challenging field of biomaterial science and for viscoelasticity-based quality control of materials.
authors.affiliation: Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center, Montreal, QC, Canada. anis.hadjhenni@rheolution.com
authors.forename: Anis
authors.initials: A
authors.lastname: Hadj Henni
authors.forename: Cédric
authors.initials: C
authors.lastname: Schmitt
authors.forename: Marie-Élise
authors.initials: MÉ
authors.lastname: Tremblay
authors.forename: Mélina
authors.initials: M
authors.lastname: Hamdine
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Heuzey
authors.forename: Pierre
authors.initials: P
authors.lastname: Carreau
authors.forename: Guy
authors.initials: G
authors.lastname: Cloutier
mesh_terms: D000362:Agar / Q000737:chemistry; D057005:Bioengineering; D004548:Elasticity; D005780:Gelatin / Q000737:chemistry; D008422:Materials Testing / Q000295:instrumentation*; D012212:Rheology; D013057:Spectrum Analysis; D013314:Stress, Mechanical; D014783:Viscosity
chemical_list: D005780:Gelatin; D000362:Agar