title: The role of cellular factors in promoting HIV budding.
abstract: Human immunodeficiency virus type 1 (HIV-1) becomes enveloped while budding through the plasma membrane, and the release of nascent virions requires a membrane fission event that separates the viral envelope from the cell surface. To facilitate this crucial step in its life cycle, HIV-1 exploits a complex cellular membrane remodeling and fission machinery known as the endosomal sorting complex required for transport (ESCRT) pathway. HIV-1 Gag directly interacts with early-acting components of this pathway, which ultimately triggers the assembly of the ESCRT-III membrane fission complex at viral budding sites. Surprisingly, HIV-1 requires only a subset of ESCRT-III components, indicating that the membrane fission reaction that occurs during HIV-1 budding differs in crucial aspects from topologically related cellular abscission events.
authors.affiliation: Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Weiss
authors.forename: Heinrich
authors.initials: H
authors.lastname: Göttlinger
mesh_terms: D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D017434:Protein Structure, Tertiary; D057074:Virus Release / Q000502:physiology*; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000737:chemistry / Q000378:metabolism
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D054301:gag Gene Products, Human Immunodeficiency Virus