title: Preparation of nanoporous SiO2 particles and their application in drug release control.
abstract: Nanoporous SiO2 particles which have different pore size and volume were prepared from a colloidal mixture of nano-sized silica particles by a spray heating method. The prepared nanoporous SiO2 particles were employed as a drug carrier to investigate the release behaviors of methylene blue (MB) as a model drug for a selected period of time. The concentration of released MB from the porous particles was measured by a UV-Vis spectroscopy with respect to time. The release of MB from the porous particles was maintained for 400 hours and the maximum amount of the released MB was 0.8 mg at 1.56 cm3/g of pore volume. As pore volume of the nanoporous particles increased, the release rate of MB increased.
authors.affiliation: Industrial Materials Research Department, Korea Institute of Geoscience and Mineral Resources, Daejeon 305-350, Korea.
authors.forename: Hee Dong
authors.initials: HD
authors.lastname: Jang
authors.forename: Dae Sup
authors.initials: DS
authors.lastname: Kil
authors.forename: Hankwon
authors.initials: H
authors.lastname: Chang
authors.forename: Kuk
authors.initials: K
authors.lastname: Cho
authors.forename: Sun Kyung
authors.initials: SK
authors.lastname: Kim
authors.forename: Kyoung Joon
authors.initials: KJ
authors.lastname: Oh
authors.forename: Jin Hoon
authors.initials: JH
authors.lastname: Choi
mesh_terms: D004337:Drug Carriers; D004563:Electrochemistry; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D012822:Silicon Dioxide / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide