title: Gastric schwannomas show an obviously increased fluorodeoxyglucose uptake in positron emission tomography: report of two cases.
abstract: Schwannomas are tumors originating from any nerve that has a Schwann cell sheath. Gastrointestinal (GI) schwannomas represent only 3% of all GI mesenchymal tumors. The stomach is the most common site of GI schwannomas, and schwannomas account for 0.2% of all gastric neoplasms. This report presents two cases of gastric schwannomas showing increased [18F]fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET; maximum standardized uptake value 7.10 and 6.05). Additional immunohistochemical staining of glucose transporter type 1 (GLUT1) and the autocrine motility factor (AMF) was conducted after the tumors were resected, to identify the mechanism that increased FDG uptake on PET. Immunohistochemical expression of AMF was positive in both cases, whereas GLUT1 was negative. Autocrine motility factor is also known as phosphoglucose isomerase. However, the mechanism by which FDG is accumulated in schwannoma cells is uncertain, and may be related to intracellular glycolytic activity.
authors.affiliation: Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohno
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Ogata
authors.forename: Norimichi
authors.initials: N
authors.lastname: Kogure
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ando
authors.forename: Ryuusuke
authors.initials: R
authors.lastname: Aihara
authors.forename: Erito
authors.initials: E
authors.lastname: Mochiki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Zai
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sano
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kato
authors.forename: Shinji
authors.initials: S
authors.lastname: Sakurai
authors.forename: Tetsunari
authors.initials: T
authors.lastname: Oyama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Asao
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged; D009442:Neurilemmoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18