title: Gene regulation: piecing together the puzzle of enhancer evolution.
abstract: The sequences of some gene regulatory elements diverge considerably, even between closely related species. A detailed analysis of the fast-evolving sparkling enhancer in Drosophila now identifies key compensatory mechanisms and 'grammar' elements that are critical for maintaining functional integrity.
authors.affiliation: Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA.
authors.forename: Rhea R
authors.initials: RR
authors.lastname: Datta
authors.forename: Stephen
authors.initials: S
authors.lastname: Small
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development*; D029721:Drosophila Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D005136:Eye Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D005136:Eye Proteins; C107990:sv protein, Drosophila