title: Coupled fluid-structure interaction hemodynamics in a zero-pressure state corrected arterial geometry.
abstract: Hemodynamic conditions in large arteries are significantly affected by the interaction of the pulsatile blood flow with the distensible arterial wall. A numerical procedure for solving the fluid-structure interaction problem encountered in cardiovascular flows is presented. We consider a patient-specific carotid bifurcation geometry, obtained from 3D reconstruction of in vivo acquired tomography images, which yields a geometrical representation of the artery corresponding to its pressurized state. To recover the geometry of the artery in its zero-pressure state which is required for a fluid-structure interaction simulation we utilize inverse finite elastostatics. Time-dependent flow simulations with in vivo measured inflow volume flow rate in the 3D undeformed artery are performed through the finite element method. The coupled-momentum method for fluid-structure interaction is adopted to incorporate the influence of wall compliance in the numerical computation of the time varying flow domain. To demonstrate the importance in recovering the zero-pressure state of the artery in hemodynamic simulations we compute the time varying flow field with compliant walls for the original and the zero-pressure state corrected geometric configurations of the carotid bifurcation. The most important resulting effects in the hemodynamic environment are evaluated. Our results show a significant change in the wall shear stress distribution and the spatiotemporal extent of the recirculation regions.
authors.affiliation: Institute of Applied and Computational Mathematics, Foundation for Research and Technology-Hellas, Heraklion, Crete 71110, Greece.
authors.forename: V
authors.initials: V
authors.lastname: Vavourakis
authors.forename: Y
authors.initials: Y
authors.lastname: Papaharilaou
authors.forename: J A
authors.initials: JA
authors.lastname: Ekaterinaris
mesh_terms: D002339:Carotid Arteries / Q000502:physiology*; D002342:Carotid Artery, External; D002343:Carotid Artery, Internal; D003198:Computer Simulation; D020342:Finite Element Analysis; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D013314:Stress, Mechanical