title: Diffusion changes in the vitreous humor of the eye during aging.
abstract: OBJECTIVE
  The inability to image the vitreous humor of the eye adequately hinders a complete understanding of its normal structure and the changes occurring in aging and disease. The purpose of the present study was to reveal normative data and age-related changes of the vitreous humor by using DWI.
  
  
  METHODS
  A total of 160 patients were enrolled in the present study. Patients were divided into 8 groups according to decade of age, and each group was of equal size with 20 patients. The ADCs were determined for each vitreous humor. Each determination was obtained by using average regions of interest of 50 ± 2 mm(2). ADC values were then plotted against age.
  
  
  RESULTS
  The ADC values obtained from group 0 (0-10 years of age) were statistically different from those of all other groups (P < .05). Group 1 (11-20 years of age) was statistically different from groups 3, 5, 6, and 7 (P < .05). A trend toward increased ADC values with increasing age was not statistically significant.
  
  
  CONCLUSIONS
  Besides the statistically significant difference between pediatric and adult patients, a statistically insignificant trend of increased ADC values among aging adults has been demonstrated. These normative data contribute to our understanding of how DWI can aid in the diagnosis of age-related changes in eye health and function.
authors.affiliation: Department of Radiology, Kirikkale Universitesi Medicine Faculty, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Meral
authors.forename: Y
authors.initials: Y
authors.lastname: Bilgili
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D014822:Vitreous Body / Q000033:anatomy & histology*; D055815:Young Adult