title: Synthesis and characterization of pH-dependent glycol chitosan and dextran sulfate nanoparticles for effective brain cancer treatment.
abstract: A novel drug delivery system for the treatment of brain tumors was formulated by methotrexate (MTX)-loaded polymeric nanoparticles (NPs) based on Glycol chitosan (GCS) and Dextran sulfate (DS). The physicochemical properties of resulting particles were investigated, evidencing the contribution of these nanoparticles for brain targeting. In vitro release of MTX was also evaluated. The GCS-DS nanoparticles have been developed based on the modulation of ratio show promise as a system for controlled delivery of the drug to the brain.
authors.affiliation: Nanostructured Materials Synthesis Laboratory, International Research Institute of Arian Chemie Gostar, Tabriz, Iran. saboktakin123@yahoo.com
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Saboktakin
authors.forename: Roya M
authors.initials: RM
authors.lastname: Tabatabaie
authors.forename: Abel
authors.initials: A
authors.lastname: Maharramov
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Ramazanov
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy*; D048271:Chitosan / Q000138:chemical synthesis* / Q000737:chemistry; D016264:Dextran Sulfate / Q000138:chemical synthesis*; D004339:Drug Compounding; D006863:Hydrogen-Ion Concentration; D008727:Methotrexate / Q000627:therapeutic use; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D013696:Temperature
chemical_list: C118638:glycol-chitosan; D048271:Chitosan; D016264:Dextran Sulfate; D008727:Methotrexate