title: Paraoxonase gene polymorphism and the risk for Alzheimer's disease in the polish population.
abstract: BACKGROUND
  The relationship between different paraoxonase (PON) gene polymorphisms and the risk of Alzheimer's disease (AD) was studied several times and the results were controversial.
  
  
  METHODS
  We investigated the association of 4 single-nucleotide polymorphisms (SNPs) of the PON1 (M55L; Q192R; -161C/T) and the PON2 (C311S) genes that were shown to affect the risk of sporadic AD. We studied 360 Caucasian cases with late-onset AD and 354 nondemented controls.
  
  
  RESULTS
  No significant differences were observed between the studied PON SNPs and AD risk. The results did not change after stratification of the apolipoprotein E status. Meta-analyses of studies in Caucasians assessing the associations between the PON1 M55L, -161C/T and Q192R SNPs and the risk of AD were performed, and no associations were found.
  
  
  CONCLUSIONS
  Our results suggest that the studied PON1 and PON2 polymorphisms are not associated with late-onset AD.
authors.affiliation: Department of Neurology, School of Medicine, Jagiellonian University, ul. Botaniczna 3, Cracow, Poland. Aleksandra.Klimkowicz@mp.pl
authors.forename: A
authors.initials: A
authors.lastname: Klimkowicz-Mrowiec
authors.forename: M
authors.initials: M
authors.lastname: Marona
authors.forename: P
authors.initials: P
authors.lastname: Wolkow
authors.forename: A
authors.initials: A
authors.lastname: Witkowski
authors.forename: A
authors.initials: A
authors.lastname: Maruszak
authors.forename: M
authors.initials: M
authors.lastname: Styczynska
authors.forename: M
authors.initials: M
authors.lastname: Barcikowska
authors.forename: A
authors.initials: A
authors.lastname: Szczudlik
authors.forename: A
authors.initials: A
authors.lastname: Slowik
mesh_terms: D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D043303:Aryldialkylphosphatase / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011153:Population; D060888:Real-Time Polymerase Chain Reaction; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D001057:Apolipoproteins E; D004247:DNA; D043303:Aryldialkylphosphatase