title: The hedgehog knows many tricks.
abstract: Contrary to the Classical Greek poet Archilochus' phrase "The fox knows many things but the hedgehog knows one big thing", the Hedgehog (HH) signaling pathway knows at least 3 ways to promote or support carcinogenesis. In this review, we provide a summary of the HH signaling pathway, and detail the clinical relevance and treatment of patients. Finally, future directions in exploiting this promising pathway will be addressed.
authors.affiliation: Scottsdale Clinical Research Institute, Scottsdale, AZ 85238, USA. gweiss@tgen.org
authors.forename: Glen J
authors.initials: GJ
authors.lastname: Weiss
authors.forename: Alain C
authors.initials: AC
authors.lastname: Mita
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Von Hoff
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D014411:Neoplastic Stem Cells / Q000502:physiology; D012107:Research Design; D015398:Signal Transduction
chemical_list: D053823:Hedgehog Proteins