title: Cutaneous manifestations in CMML: Indication of disease acceleration or transformation to AML and review of the literature.
abstract: Our retrospective analysis explored the role of leukemia cutis (LC) in disease progression of chronic myelomonocytic leukemia (CMML). Of 108 patients with CMML, 11 patients (10.2%) had LC including its equivalent (2 patients). Four of these patients developed acute myeloid leukemia (AML) within 0-4 months. The remaining 7 patients demonstrated increased monocytes (<20% blasts), with 3 demonstrating extramedullary involvement. Overall survival from LC to disease progression was 7.8 months. Overall survival from diagnosis to the last follow-up in patients with LC was 28.2 months, shorter than patients without LC (44 months). LC and its equivalent could predict disease progression to AML.
authors.affiliation: University of South Florida, School of Medicine, Tampa, FL, USA.
authors.forename: Rahel A
authors.initials: RA
authors.lastname: Mathew
authors.forename: John M
authors.initials: JM
authors.lastname: Bennett
authors.forename: Jane Jijun
authors.initials: JJ
authors.lastname: Liu
authors.forename: Rami S
authors.initials: RS
authors.lastname: Komrokji
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Lancet
authors.forename: Mojdeh
authors.initials: M
authors.lastname: Naghashpour
authors.forename: Jane L
authors.initials: JL
authors.lastname: Messina
authors.forename: Alan F
authors.initials: AF
authors.lastname: List
authors.forename: Lynn C
authors.initials: LC
authors.lastname: Moscinski
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000054:Acceleration; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis