title: [Repair system engineering and the concept of sequential cytoprotection in treatment of burn].
abstract: It has been an essential trend to understand and solve the difficult problems arising in the treatment process of burn with views of holistic theory. Recent researches have indicated that the driven factors and the termination signals of repair system engineering in treatment of burn are the unity of two opposite rather than two independent bodies with chronological order. Repair driven factors are germinated at the cost of systemic inflammatory response and even multiple organ damage. Inflammatory response is both a necessary procedure of burn repair and the pathological basis of multiple system dysfunction after burn. A comprehensive burn therapy nominated sequential cytoprotection (SCP) strategy has emerged in which the knowledge derived from basic research is translated to clinical practice stepwise, and it might play an important role in treatment of severe burn. Further multi-center randomized controlled clinical trials should be conducted in order to raise the level of SCP strategy in guideline of evidence-based medicine.
authors.affiliation: Institute of Burn Research, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China.
authors.forename: Zhao-fan
authors.initials: ZF
authors.lastname: Xia
authors.forename: Kai-yang
authors.initials: KY
authors.lastname: Lü
mesh_terms: D002056:Burns / Q000628:therapy*; D019610:Cytoprotection; D019317:Evidence-Based Medicine; D006801:Humans; D019651:Plastic Surgery Procedures; D014945:Wound Healing