title: Epidemiology of renal cell cancer.
abstract: Renal cell cancer (RCC) is increasingly diagnosed at an early stage in many countries, which likely contributes to the recent leveling of RCC mortality in the United States and many European countries. However, over all stages nearly 50% of the patients die within 5 years after diagnosis. Smoking and obesity may account for approximately 40% of all incidental cases in high-risk countries. Besides obesity, rising prevalence of hypertension may play a growing role. Several other occupational and lifestyle factors may also affect the risk of RCC. Genetic variations may be an important factor in the differing incidence among populations.
authors.affiliation: Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA. eunyoung.cho@channing.harvard.edu
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Cho
authors.forename: Hans-Olov
authors.initials: HO
authors.lastname: Adami
authors.forename: Per
authors.initials: P
authors.lastname: Lindblad
mesh_terms: D002292:Carcinoma, Renal Cell / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D005060:Europe / Q000453:epidemiology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000150:complications; D015994:Incidence; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D009765:Obesity / Q000150:complications; D015995:Prevalence; D014481:United States / Q000453:epidemiology