title: Alcoholic-induced hepatic steatosis--role of ceramide and protein phosphatase 2A.
abstract: The mechanisms underlying alcohol-induced hepatic steatosis are complex, involving the disturbance of several signaling pathways. We have gained a better understanding of the role of the innate immune system in the liver and its effects on lipid metabolism and uncovered a number of circulating factors that can influence the response of the liver to ethanol. In this report, we will focus on the potential role of ceramide on AMP-activated protein kinase, as a mediator of alcohol-induced hepatic steatosis.
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202-5124, USA.
authors.forename: Rodjawan
authors.initials: R
authors.lastname: Supakul
authors.forename: Suthat
authors.initials: S
authors.lastname: Liangpunsakul
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000818:Animals; D002518:Ceramides / Q000502:physiology*; D004789:Enzyme Activation; D000431:Ethanol / Q000633:toxicity; D005235:Fatty Liver, Alcoholic / Q000209:etiology*; D006801:Humans; D010766:Phosphorylation; D054648:Protein Phosphatase 2 / Q000502:physiology*
chemical_list: D002518:Ceramides; D000431:Ethanol; D055372:AMP-Activated Protein Kinases; D054648:Protein Phosphatase 2