title: Body size-adapted dose of contrast material and scanning protocol in 320-detector row CT coronary angiography.
abstract: OBJECTIVE
  Because an increase in patient body size produces lower vessel attenuation and higher image noise in computed tomography coronary angiography (CTCA), a protocol in which the dose of contrast material was adapted to the body weight, and tube voltage and current were adapted to the body mass index (BMI) was evaluated.
  
  
  METHODS
  A total of 136 patients who underwent CTCA were assigned to 1 of 2 protocols; the patients received 40 mL of contrast material (A; n = 52), or 0.7 mL/kg of contrast material (B; n = 84). Tube voltage and current were adapted to the BMI.
  
  
  RESULTS
  In group A, there was no significant correlation between BMI and image noise (r = -0.21, P = 0.15). However, BMI correlated inversely with contrast-to-noise ratio (CNR; right coronary artery, r = -0.29, P < 0.05; left main coronary artery, r = -0.33, P < 0.05) and image quality score (r = -0.55, P < 0.001). In group B, there was no significant correlation between BMI and image noise (r = -0.14, P = 0.21), CNR (right coronary artery: r = -0.09, P = 0.45; left main coronary artery: r = -0.07, P = 0.55), and image quality score (r = 0.03, P = 0.79).
  
  
  CONCLUSIONS
  Use of a body size-adapted dose of contrast material and scanning protocol results in similar CNR and image quality independent of individual BMI.
authors.affiliation: Department of Radiology, Osaka Medical College, Takatsuki City, Osaka, Japan. sa104@rg8.so-net.ne.jp
authors.forename: Fuminari
authors.initials: F
authors.lastname: Tatsugami
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Matsuki
authors.forename: Go
authors.initials: G
authors.lastname: Nakai
authors.forename: Yuki
authors.initials: Y
authors.lastname: Inada
authors.forename: Shuji
authors.initials: S
authors.lastname: Kanazawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeda
authors.forename: Hideaki
authors.initials: H
authors.lastname: Morita
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Takada
authors.forename: Shushi
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: Katsunori
authors.initials: K
authors.lastname: Fukumura
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Narumi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049628:Body Size; D003287:Contrast Media / Q000008:administration & dosage*; D017023:Coronary Angiography / Q000379:methods*; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007479:Iopamidol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol