title: Current evidence on the safety profile of NSAIDs for the treatment of PDA.
abstract: Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants. Nonsteroidal anti-inflammatory drugs, especially Indomethacin and Ibuprofen, have been widely used for both prevention and treatment of PDA. Short-term efficacy of Indomethacin or Ibuprofen is equivalent, while Ibuprofen results show a higher safety profile. Ibuprofen is associated with fewer clinical gastrointestinal and renal side effects with respect to Indomethacin even if subclinical potential effects are reported. When administered as prophylaxis, Ibuprofen has no effects on prevention of intraventricular haemorrhage unlike Indomethacin. Considering the potential adverse effects of both these drugs, a careful monitoring during and after the treatment period is highly recommended.
authors.affiliation: Department of Paediatrics and Division of Neonatology, Catholic University of Sacred Heart, Rome, Italy. cromagnoli@rm.unicatt.it
authors.forename: Costantino
authors.initials: C
authors.lastname: Romagnoli
authors.forename: Iliana
authors.initials: I
authors.lastname: Bersani
authors.forename: Serena Antonia
authors.initials: SA
authors.lastname: Rubortone
authors.forename: Serafina
authors.initials: S
authors.lastname: Lacerenza
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: De Carolis
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001663:Bilirubin / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D041981:Gastrointestinal Tract / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D007668:Kidney / Q000187:drug effects; D008168:Lung / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001663:Bilirubin