title: Inhibition of azoxymethane-induced preneoplastic lesions in the rat colon by a cooked stearic acid complexed high-amylose cornstarch.
abstract: This study evaluated a novel stearic acid complexed high-amylose cornstarch (SAC) for the prevention of preneoplastic lesions in the colon of azoxymethane (AOM)-treated Fisher 344 rats fed resistant starches at 50-55% of the diet for 8 weeks. Uncooked SAC (r-SAC) diet was compared with raw normal-cornstarch diet (r-CS) or raw high-amylose cornstarch diet (r-HA), and water-boiled CS (w-CS) was compared with w-HA and w-SAC, respectively. w-SAC markedly reduced mucin-depleted foci (MDF) numbers compared with w-HA or w-CS. r-HA significantly decreased aberrant crypt foci (ACF) numbers compared with r-CS or r-SAC. Increased cecum weight and decreased cecum pH were observed in the SAC or HA groups. The highest amounts of total or individual short-chain fatty acids (SCFAs) in cecum and of butyrate or propionate in feces were observed in the AOM-treated w-SAC group. This study revealed the effectiveness of a novel resistant starch in inhibiting colonic preneoplastic lesions and the importance of high-moisture cooking on the suppression of colon carcinogenesis by this resistant starch.
authors.affiliation: Department of Food Science and Human Nutrition, 220 MacKay Hall, Iowa State University, Ames, Iowa 50011-1123, United States.
authors.forename: Yinsheng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jovin
authors.initials: J
authors.lastname: Hasjim
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Jay-Lin
authors.initials: JL
authors.lastname: Jane
authors.forename: Suzanne
authors.initials: S
authors.lastname: Hendrich
authors.forename: Diane F
authors.initials: DF
authors.lastname: Birt
mesh_terms: D000688:Amylose / Q000008:administration & dosage*; D000818:Animals; D001397:Azoxymethane; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004032:Diet; D005232:Fatty Acids, Volatile / Q000032:analysis; D006358:Hot Temperature; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011916:Rats, Inbred F344; D013213:Starch / Q000008:administration & dosage*; D013229:Stearic Acids / Q000008:administration & dosage*
chemical_list: D002273:Carcinogens; D005232:Fatty Acids, Volatile; D013229:Stearic Acids; D013213:Starch; D000688:Amylose; D001397:Azoxymethane