title: Clostridium difficile infection after malaria chemoprophylaxis with doxycycline: is there an association?
abstract: Malaria chemoprophylaxis with doxycycline is commonly used in the United Kingdom and in many other countries. It is considered to be associated with an increased risk of Clostridium difficile associated diarrhea (CDAD). We describe a case of diarrhea and a positive stool assay for C. difficile in a returning traveler, and review available literature. The commonly held concept of an association between doxycycline chemoprophylaxis and CDAD is not supported by available data.
authors.affiliation: The Unit of Infectious Diseases, Rambam Medical Center, Haifa, Israel.
authors.forename: Ami
authors.initials: A
authors.lastname: Neuberger
authors.forename: Eli
authors.initials: E
authors.lastname: Schwartz
mesh_terms: D000328:Adult; D015766:Albendazole / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D000962:Antimalarials / Q000009:adverse effects* / Q000627:therapeutic use; D001938:Brazil; D002677:Chile; D002908:Chronic Disease; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000139:chemically induced* / Q000469:parasitology*; D004318:Doxycycline / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000382:microbiology* / Q000517:prevention & control; D014195:Travel
chemical_list: D000962:Antimalarials; D015766:Albendazole; D004318:Doxycycline