title: The effects of magnesium sulfate on maternal and fetal platelet aggregation.
abstract: OBJECTIVE
  To evaluate platelet function in mothers and fetuses/neonates exposed to magnesium sulfate intrapartum.
  
  
  METHODS
  This was a prospective cohort study of mothers and fetuses/neonates exposed to magnesium sulfate intrapartum compared to mothers and fetuses/neonates not exposed. Platelet aggregometry was performed in duplicate on specimens from subjects using two different agonists, ADP and collagen, on a whole blood impedance aggregometer.
  
  
  RESULTS
  Specimens were processed from 11 mothers and 10 fetuses/neonates exposed to magnesium and 12 mothers and fetuses/neonates, not exposed. There was no difference in platelet aggregation between the specimens from the mothers who were exposed and mothers not exposed. In the specimens from the fetuses/neonates, there was no difference using collagen as an agonist, but using ADP as an agonist, there was a remarkable difference - 0.0 ohms in the exposed group vs. 3.0 ohms in the unexposed group (p < 0.01).
  
  
  CONCLUSIONS
  In-utero magnesium sulfate exposure significantly suppresses fetal platelet function.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Duke University School of Medicine, Durham, NC, USA.
authors.forename: Eleanor
authors.initials: E
authors.lastname: Rhee
authors.forename: Timothy
authors.initials: T
authors.lastname: Beiswenger
authors.forename: Chinazor E
authors.initials: CE
authors.lastname: Oguejiofor
authors.forename: Andra H
authors.initials: AH
authors.lastname: James
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005312:Fetal Blood / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric; D008278:Magnesium Sulfate / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D010974:Platelet Aggregation / Q000187:drug effects*; D011225:Pre-Eclampsia; D011247:Pregnancy; D011446:Prospective Studies; D012640:Seizures / Q000517:prevention & control; D015149:Tocolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D015149:Tocolytic Agents; D008278:Magnesium Sulfate