title: Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men.
abstract: More than 30 prostate cancer (PCa) risk-associated loci have been identified in populations of European descent by genome-wide association studies. We hypothesized that a subset of these loci might be associated with PCa risk in Chinese men. To test this hypothesis, 33 single nucleotide polymorphisms (SNP), one each from the 33 independent PCa risk-associated loci reported in populations of European descent, were investigated for their associations with PCa risk in a case-control study of Chinese men (1108 cases and 1525 controls). We found that 11 of the 33 SNP were significantly associated with PCa risk in Chinese men (P < 0.05). The reported risk alleles were associated with increased risk for PCa, with allelic odds ratios ranging from 1.12 to 1.44. The most significant locus was located on 8q24 region 2 (rs16901979, P = 5.14 × 10(-9)) with a genome-wide significance (P < (-8) ), and three loci reached the Bonferroni correction significance level (P < 1.52 × 10(-3)), including 8q24 region 1 (rs1447295, P = 7.04 × 10(-6)), 8q24 region 5 (rs10086908, P = 9.24 × 10(-4)) and 8p21 (rs1512268, P = 9.39 × 10(-4)). Our results suggest that a subset of the PCa risk-associated SNP discovered by genome-wide association studies among men of European descent is also associated with PCa risk in Chinese men. This finding provides evidence of ethnic differences and similarity in genetic susceptibility to PCa. Genome-wide association studies in Chinese men are needed to identify Chinese-specific PCa risk-associated SNP.
authors.affiliation: Fudan-VARI Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Ann W
authors.initials: AW
authors.lastname: Hsing
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Qiang
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authors.lastname: Shao
authors.forename: Jun
authors.initials: J
authors.lastname: Qi
authors.forename: Yu
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authors.lastname: Ye
authors.forename: Zhong
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authors.lastname: Wang
authors.forename: Hongyan
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authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
authors.forename: Guozeng
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authors.lastname: Wang
authors.forename: Lisa W
authors.initials: LW
authors.lastname: Chu
authors.forename: Qiang
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authors.lastname: Ding
authors.forename: Jun
authors.initials: J
authors.lastname: OuYang
authors.forename: Xu
authors.initials: X
authors.lastname: Gao
authors.forename: Yichen
authors.initials: Y
authors.lastname: Huang
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Chen
authors.forename: Yu Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Zhang
authors.forename: Jianyu
authors.initials: J
authors.lastname: Rao
authors.forename: Rong
authors.initials: R
authors.lastname: Shi
authors.forename: Qijun
authors.initials: Q
authors.lastname: Wu
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Haowen
authors.initials: H
authors.lastname: Jiang
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Hu
authors.forename: Ling
authors.initials: L
authors.lastname: Guo
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Lin
authors.forename: Sha
authors.initials: S
authors.lastname: Tao
authors.forename: Guangfu
authors.initials: G
authors.lastname: Jin
authors.forename: Jielin
authors.initials: J
authors.lastname: Sun
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.forename: Yinghao
authors.initials: Y
authors.lastname: Sun
authors.forename: Zengnan
authors.initials: Z
authors.lastname: Mo
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
mesh_terms: D044466:Asian People / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor