title: Prognostic significance of osteopontin in hepatocellular carcinoma: a meta-analysis.
abstract: Osteopontin (OPN) has been implicated in tumor development and progression for several years. However, the prognostic value of OPN overexpression in patients with hepatocellular carcinoma (HCC) remains controversial. We performed a meta-analysis to assess the relationship between OPN overexpression and clinical outcome of HCC. A meta-analysis of seven studies (1,158 patients) was carried out to evaluate the association between OPN and overall survival (OS) and disease-free survival (DFS) in HCC patients. The correlation between OPN and tumor vascular invasion or other invasion-related parameters was also assessed. Data were synthesized with random effect model of DerSimonian and Laird, hazard ratio (HR) or odds ratio (OR) with its 95% confidence interval (CI) was used as the effect size estimate. Our analysis results indicated that high OPN expression predicted poor OS (HR: 1.37, 95% CI: 1.21-1.55) and DFS (HR: 1.62, 95% CI: 1.24-2.11) of HCC. OPN overexpression tended to be associated with the presence of tumor vascular invasion (OR: 1.93, 95% CI: 0.97-3.84) and advanced tumor grade (OR: 1.74, 95% CI: 0.95-3.18). By this study, we conclude that OPN overexpression indicates a poor prognosis for patients with HCC, it may also have predictive potential for HCC invasion and metastasis.
authors.affiliation: Department of Hepatic Surgery, Affiliated Provincial Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
authors.forename: Chuan-Hai
authors.initials: CH
authors.lastname: Zhang
authors.forename: Ge-Liang
authors.initials: GL
authors.lastname: Xu
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Jia
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Ge
authors.forename: Jian-Sheng
authors.initials: JS
authors.lastname: Li
authors.forename: Jin-Liang
authors.initials: JL
authors.lastname: Ma
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Ren
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000737:chemistry / Q000401:mortality* / Q000473:pathology; D018572:Disease-Free Survival; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000737:chemistry / Q000401:mortality* / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D053495:Osteopontin / Q000032:analysis* / Q000502:physiology; D011379:Prognosis; D017594:Publication Bias
chemical_list: D053495:Osteopontin