title: Risk and prognostic factors of status epilepticus in the elderly: a case-control study.
abstract: OBJECTIVE
  The aim of this study was to assess the risk and prognostic factors of status epilepticus (SE) among elderly inpatients.
  
  
  METHODS
  From May 2003 to April 2005, 63 consecutive patients aged 70 years or older with SE were included. Each patient was matched to three controls without SE seen during the same period. Matching variables were age (±3 years), gender, and comorbidity index (±3). Multivariate logistic regression model were used to compare cases to controls and, among the cases, nonsurvivors to survivors.
  
  
  RESULTS
  By multivariate analysis, factors independently associated with SE were acute decompensation (cardiac, respiratory, or hepatic) [adjusted odds ratio (OR(a) ) 2.57, 95% confidence interval (95% CI) 1.05-6.25] history of epilepsy (OR(a) 3.93, 95% CI 1.27-12.14), chronic cerebrovascular disease (OR(a) 7.96, 95% CI 3.31-19.15), nonvascular dementia (OR(a) 4.16, 95% CI 1.86-9.29), and dysnatremia (OR(a) 5.08, 95% CI 2.34-11.04). In-hospital 1-month mortality was 2.3 times higher among cases than controls (14/63, 22.0%; 95% CI 12.7-34.5%; vs. 18/189, 9.5%; 95% CI 5.7-14.7%; p = 0.01). Among the cases, factors independently associated with in-hospital death within 1 month were younger age (OR(a) per 1-year increase 0.87, 95% CI 0.76-0.98), higher comorbidity index (OR(a) per 1-point increase 1.27, 95% CI 1.07-1.55), and de novo SE (OR(a) 14.95, 95% CI 2.24-192.8).
  
  
  CONCLUSIONS
  Independent predictors of SE in hospitalized patients aged 70 years or older were acute decompensation (cardiac, respiratory, or hepatic), history of epilepsy, chronic cerebrovascular disease, nonvascular dementia, and dysnatremia. Factors that independently predicted death in patients with SE were younger age, higher comorbidity index, and de novo SE.
authors.affiliation: Faculty of Medicine, Paris-Est University, LIC EA 4393, Créteil, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Canouï-Poitrine
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bastuji-Garin
authors.forename: Eliana
authors.initials: E
authors.lastname: Alonso
authors.forename: Gaelle
authors.initials: G
authors.lastname: Darcel
authors.forename: Patrick
authors.initials: P
authors.lastname: Verstichel
authors.forename: Philippe
authors.initials: P
authors.lastname: Caillet
authors.forename: Elena
authors.initials: E
authors.lastname: Paillaud
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000150:complications; D016009:Chi-Square Distribution; D004569:Electroencephalography; D005260:Female; D006333:Heart Failure / Q000150:complications; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D018709:Statistics, Nonparametric; D013226:Status Epilepticus / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics