title: Sodium-phosphorylated chitosan/zinc oxide complexes and evaluation of their cytocompatibility: an approach for periodontal dressing.
abstract: The aim of this study was to evaluate the possibility of metal complex formation between sodium-phosphorylated chitosan (PCTS) and ZnO. The polymer-metal complex formation was investigated in terms of thermal degradation. The structure deduction of the PCTS/ZnO complex was investigated by means of Fourier transform infrared spectroscopy and X-ray diffraction (XRD). The PCTS/ZnO complexes were formed by the sharing of lone pairs of electrons from the N atoms in the amine groups and O atoms in the phosphate and hydroxyl groups of PCTS to the protonated hydroxyl species on the ZnO surface. Because complex formation occurred at the surface of ZnO particles, it did not change the ZnO crystalline structure. Cytotoxicity, evaluated by a direct contact test with primary human gingival fibroblast cells, revealed that PCTS was biocompatible and reduced the cytotoxicity of ZnO by complexation, making PCTS/ZnO complexes potentially biocompatible. Within the limits of these data, it appears that PCTS could be used as a reaction rate-modifying agent in periodontal dressings.
authors.affiliation: Department of Materials Science, Faculty of Science, Chulalongkorn University, Phyathai, Patumwan, Bangkok 10330, Thailand.
authors.forename: Veeranuch
authors.initials: V
authors.lastname: Srakaew
authors.forename: Praphansri
authors.initials: P
authors.lastname: Ruangsri
authors.forename: Kanyarat
authors.initials: K
authors.lastname: Suthin
authors.forename: Pasutha
authors.initials: P
authors.lastname: Thunyakitpisal
authors.forename: Wanpen
authors.initials: W
authors.lastname: Tachaboonyakiat
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry* / Q000633:toxicity; D056831:Coordination Complexes / Q000737:chemistry* / Q000633:toxicity; D005881:Gingiva / Q000166:cytology; D006801:Humans; D010511:Periodontal Dressings / Q000009:adverse effects; D010766:Phosphorylation; D012964:Sodium / Q000737:chemistry* / Q000633:toxicity; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry* / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; D056831:Coordination Complexes; D048271:Chitosan; D012964:Sodium; D015034:Zinc Oxide