title: Evaluating the progenitor cells of ovarian cancer: analysis of current animal models.
abstract: Serous ovarian cancer is one of the most lethal gynecological malignancies. Progress on effective diagnostics and therapeutics for this disease are hampered by ambiguity as to the cellular origins of this histotype of ovarian cancer, as well as limited suitable animal models to analyze early stages of disease. In this report, we will review current animal models with respect to the two proposed progenitor cells for serous ovarian cancer, the ovarian surface epithelium and the fallopian tube epithelium.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 60607, USA.
authors.forename: Shelby M
authors.initials: SM
authors.lastname: King
authors.forename: Joanna E
authors.initials: JE
authors.lastname: Burdette
mesh_terms: D000818:Animals; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005069:Evaluation Studies as Topic; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D023421:Models, Animal; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*