title: Force-driven polymer translocation through a nanopore: an old problem revisited.
abstract: We consider DNA translocation through a pore in a planar membrane. The pore is so narrow that only one DNA segment can fit in. Assuming that the biasing force f acts inside the pore only, and that the DNA monomer number N is asymptotically large, we modify the previously developed treatment of the stretched part of the pre-translocated polymer by introducing the concept of "iso-flux trumpet". We show that friction of a moving chain in the trumpet, although it determines the speed of the process, provides only a marginal fraction of overall dissipation in the process. The dominant dissipation turns out to be due to irreversible entropic squeezing of the chain into the small pore. We also discover that because of the role of the membrane a much larger amount of heat of order k(B)T per monomer gets transferred from the heat bath on the post-translocation side to that on the pre-translocation side.
authors.affiliation: Department of Physics, Center for Soft Matter Research, New York University, New York, New York 10003, USA. payam.rowghanian@physics.nyu.edu
authors.forename: Payam
authors.initials: P
authors.lastname: Rowghanian
authors.forename: Alexander Y
authors.initials: AY
authors.lastname: Grosberg
mesh_terms: D004247:DNA / Q000737:chemistry; D008958:Models, Molecular; D058608:Nanopores; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers; D004247:DNA