title: Age related alterations of adrenoreceptor activity in erythrocyte membrane.
abstract: The aim of the study was the investigation of age-related functional alterations of adrenoreceptors and the effect of agonist and antagonist drugs on age related adrenoreceptor activity in erythrocyte membrane. The impact of isopropanol and propanol on functional activity β- adrenergic receptors in red blood cell membrane were studied in 50 practically healthy men--volunteers. (I group--75-89 years old, II group--22-30 years old). The EPR signals S1 and S2 were registered in red blood cell membrane samples after incubation with isopropanol and propanol respectively. It was found that decreasing sensitivity (functional activity) of red blood cells membrane adrenoreceptors comes with aging (S1old<S1yang by 22% and. S2old<S2yang by 25%). Progressive reduction sensitivity and/or reactivity of beta-adrenoreceptor may be induced by changing structural sensitivity, reducing their number, or depletion of intracellular ATP; it may involve in pathogenesis of age-related hypertension, heart failure, type II diabetes and other diseases, The findings suggests that the erythrocyte could be a new therapeutic marker in the treatment different diseases.
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: G
authors.initials: G
authors.lastname: Lomsadze
authors.forename: R
authors.initials: R
authors.lastname: Khetsuriani
authors.forename: M
authors.initials: M
authors.lastname: Arabuli
authors.forename: N
authors.initials: N
authors.lastname: Intskirveli
authors.forename: T
authors.initials: T
authors.lastname: Sanikidze
mesh_terms: D000433:1-Propanol / Q000494:pharmacology; D019840:2-Propanol / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008297:Male; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D000433:1-Propanol; D019840:2-Propanol