title: Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model.
abstract: Modern stereological techniques have been used to show that the total length of the cholinergic fibers in the cerebral cortex of the APPswe/PS1deltaE9 mouse is reduced by almost 300 meters at 18 months of age and has a nonlinear relationship to the amount of transgenetically-induced amyloidosis. These data provide rigorous quantitative morphological evidence that Alzheimer's-like amyloidosis affects the axons of the cholinergic enervation of the cerebral cortex.
authors.affiliation: Institute for Biomedicine, Aarhus University, Aarhus, Denmark.
authors.forename: Gitte Nykjær
authors.initials: GN
authors.lastname: Nikolajsen
authors.forename: Morten Skovgaard
authors.initials: MS
authors.lastname: Jensen
authors.forename: Mark J
authors.initials: MJ
authors.lastname: West
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D001369:Axons / Q000378:metabolism / Q000473:pathology*; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D051379:Mice
chemical_list: D000109:Acetylcholine