title: Recent advances in p97/VCP/Cdc48 cellular functions.
abstract: p97/VCP/Cdc48 is one of the best-characterized type II AAA (ATPases associated with diverse cellular activities) ATPases. p97 is suggested to be a ubiquitin-selective chaperone and its key function is to disassemble protein complexes. p97 is involved in a wide variety of cellular activities. Recently, novel functions, namely autophagy and mitochondrial quality control, for p97 have been uncovered. p97 was identified as a causative factor for inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD) and more recently as a causative factor for amyotrophic lateral sclerosis (ALS). In this review, we will summarize and discuss recent progress and topics in p97 functions and the relationship to its associated diseases.
authors.affiliation: Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Yamanaka
authors.forename: Yohei
authors.initials: Y
authors.lastname: Sasagawa
authors.forename: Teru
authors.initials: T
authors.lastname: Ogura
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D060746:Endoplasmic Reticulum-Associated Degradation; D006801:Humans; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D009154:Mutation; D018979:Myositis, Inclusion Body / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D059748:Proteolysis; D057149:Ubiquitinated Proteins / Q000378:metabolism; D000074405:Valosin Containing Protein
chemical_list: D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D057149:Ubiquitinated Proteins; D000251:Adenosine Triphosphatases; C000614178:VCP protein, human; D000074405:Valosin Containing Protein