title: Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses.
abstract: BACKGROUND
  Proteomic analysis was performed to identify proteins regulated during infection by Dengue serotypes 1 and 3 in an Aedes albopictus cell line. The potential of these viruses to cause severe disease at primary infection is of interest although few studies have been performed with these two Dengue serotypes.
  
  
  RESULTS
  The most relevant observation of our study is the significant overexpression of proteins involved in the cellular stress response and the glycolysis pathway after 48 hours of infection. Viral infection activates the translation of some host genes, which may result in stress due to responses involving unfolded proteins.
  
  
  CONCLUSIONS
  Therefore, the oxidation reduction and glycolytic mechanisms could participate in the antiviral response against Dengue virus. The results of our study should help to improve our knowledge of the virus-mosquito interaction at a cellular level with the aim of designing efficient strategies for the control of Dengue virus.
authors.affiliation: Laboratoire Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution, Contrôle, UMR 5290 CNRS/IRD/UM1, Montpellier, France.
authors.forename: Sirilaksana
authors.initials: S
authors.lastname: Patramool
authors.forename: Pornapat
authors.initials: P
authors.lastname: Surasombatpattana
authors.forename: Natthanej
authors.initials: N
authors.lastname: Luplertlop
authors.forename: Martial
authors.initials: M
authors.lastname: Sévéno
authors.forename: Valérie
authors.initials: V
authors.lastname: Choumet
authors.forename: Frédéric
authors.initials: F
authors.lastname: Thomas
authors.forename: Dorothée
authors.initials: D
authors.lastname: Missé
mesh_terms: D000330:Aedes / Q000737:chemistry* / Q000821:virology*; D000818:Animals; D002460:Cell Line; D003716:Dengue Virus / Q000254:growth & development*; D019476:Insect Proteins / Q000032:analysis*; D020543:Proteome
chemical_list: D019476:Insect Proteins; D020543:Proteome