title: Galectin-3 is upregulated in activated glia during Junin virus-induced murine encephalitis.
abstract: Argentine haemorrhagic fever (AHF) is a systemic febrile syndrome characterized by several haematological and neurological alterations caused by Junín virus (JUNV), a member of the Arenaviridae family. Newborn mice are highly susceptible to JUNV and the course of infection has been associated with the viral strain used. Galectin-3 (Gal-3) is an animal lectin that has been proposed to play an important role in some central nervous system (CNS) diseases. In this study, we analysed Gal-3 expression at the transcriptional and translational expression levels during JUNV-induced CNS disease. We found that Candid 1 strain induced, with relatively low mortality, a subacute/chronic CNS disease with significant glia activation and upregulation of Gal-3 in microglia cells as well as in reactive astrocytes that correlated with viral levels. Our results suggest an important role for Gal-3 in viral-induced CNS disease.
authors.affiliation: Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina.
authors.forename: Carolina
authors.initials: C
authors.lastname: Jaquenod De Giusti
authors.forename: Lucrecia
authors.initials: L
authors.lastname: Alberdi
authors.forename: Jesica
authors.initials: J
authors.lastname: Frik
authors.forename: María F
authors.initials: MF
authors.lastname: Ferrer
authors.forename: Emilia
authors.initials: E
authors.lastname: Scharrig
authors.forename: Mirta
authors.initials: M
authors.lastname: Schattner
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Gomez
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001117:Arenaviridae Infections / Q000378:metabolism* / Q000473:pathology; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology / Q000821:virology; D004195:Disease Models, Animal; D018792:Encephalitis, Viral / Q000378:metabolism* / Q000473:pathology; D037502:Galectin 3 / Q000096:biosynthesis*; D006478:Hemorrhagic Fever, American / Q000378:metabolism / Q000473:pathology / Q000821:virology; D018051:Junin virus / Q000472:pathogenicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000378:metabolism / Q000473:pathology / Q000821:virology; D009457:Neuroglia / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D015854:Up-Regulation / Q000502:physiology*
chemical_list: D037502:Galectin 3