title: Anti-inflammatory activity of the non-peptidyl low molecular weight radical scavenger IAC in carrageenan-induced oedema in rats.
abstract: OBJECTIVE
  In this research we investigated the anti-inflammatory activity of a non-peptidyl low molecular weight radical scavenger (IAC) in an acute and chronic animal model of inflammation.
  
  
  METHODS
  For this purpose the effect of IAC (10, 25, 50 mg/kg) was tested in rats on the associated behavioral responses to subsequent inflammatory and noxious challenges, such as hind paw oedema induced by intra-plantar injection of carrageenan and granuloma induced by subcutaneous implant of a cotton pellet, using indometacin (2.5 mg/kg) as reference drug. Moreover, the serum level of several cytokines was tested in the animal treated (or not) with IAC (50 mg/kg) both in the absence and presence of carrageenan-induced inflammation.
  
  
  RESULTS
  IAC showed a significant anti-inflammatory activity in both in acute and chronic models of inflammation. In addition IAC down regulated significantly the serum levels of interleukin (IL) 2 and IL6 whereas it increased the serum concentration of IL1α and glutathione.
  
  
  CONCLUSIONS
  Although it remains to be elucidated whether or not the antioxidant property of IAC is directly responsible for the modulation of the tested cytokines, these results suggest IAC to be a possible candidate for a novel anti-inflammatory compound.
authors.affiliation: Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy. corsi.lorenzo@unimore.it
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Corsi
authors.forename: Manuela
authors.initials: M
authors.lastname: Zavatti
authors.forename: Elisa
authors.initials: E
authors.lastname: Geminiani
authors.forename: Paola
authors.initials: P
authors.lastname: Zanoli
authors.forename: Mario
authors.initials: M
authors.lastname: Baraldi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan / Q000633:toxicity; D004195:Disease Models, Animal; D015536:Down-Regulation; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood; D015745:Granuloma, Foreign-Body / Q000188:drug therapy*; D053582:Interleukin-1alpha / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008970:Molecular Weight; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000893:Anti-Inflammatory Agents; D016166:Free Radical Scavengers; D053582:Interleukin-1alpha; D007376:Interleukin-2; D015850:Interleukin-6; D010880:Piperidines; C526136:bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioate; D002351:Carrageenan; D005978:Glutathione