title: Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor.
abstract: The maturation of primary microrRNAs (pri-miRNAs) to precursor miRNAs (pre-miRNAs) is mediated by the "microprocessor" complex minimally comprimising two core components, Drosha and DGCR8. However, the roles of RNA-binding proteins associated with these core units in the large Drosha complex remain to be defined. While signal-dependent regulation of miRNA biogenesis is assumed, such regulation remains to be described. here, we provide a short review based on our recent findings of hormonally-regulated pri-miRNA processing by nuclear estrogen receptor.
authors.affiliation: , .
authors.forename: Sally
authors.initials: S
authors.lastname: Fujiyama-Nakamura
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yamagata
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Kato
mesh_terms: D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D011506:Proteins / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D016601:RNA-Binding Proteins / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D043244:Ribonuclease III; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs; D011506:Proteins; D016601:RNA-Binding Proteins; D011960:Receptors, Estrogen; D043244:Ribonuclease III