title: Effects of triazole derivatives on strigolactone levels and growth retardation in rice.
abstract: We previously discovered a lead compound for strigolactone (SL) biosynthesis inhibitors, TIS13 (2,2-dimethyl-7-phenoxy-4-(1H-1,2,4-triazol-1-yl)heptan-3-ol). Here, we carried out a structure-activity relationship study of TIS13 to discover more potent and specific SL biosynthesis inhibitor because TIS13 has a severe side effect at high concentrations, including retardation of the growth of rice seedlings. TIS108, a new TIS13 derivative, was found to be a more specific SL biosynthesis inhibitor than TIS13. Treatment of rice seedlings with TIS108 reduced SL levels in both roots and root exudates in a concentration-dependent manner and did not reduce plant height. In addition, root exudates of TIS108-treated rice seedlings stimulated Striga germination less than those of control plants. These results suggest that TIS108 has a potential to be applied in the control of root parasitic weeds germination.
authors.affiliation: Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Ito
authors.forename: Mikihisa
authors.initials: M
authors.lastname: Umehara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hanada
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kitahata
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hayase
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Tadao
authors.initials: T
authors.lastname: Asami
mesh_terms: D001681:Biological Assay; D018525:Germination / Q000187:drug effects; D006588:Hexanones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007783:Lactones / Q000378:metabolism / Q000494:pharmacology*; D012275:Oryza / Q000187:drug effects* / Q000254:growth & development*; D036226:Seedlings / Q000187:drug effects / Q000254:growth & development; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C000588889:6-phenoxy-1-phenyl-2-(1H-1,2,4-trizol-1-yl)hexan-1-one; D006588:Hexanones; D007783:Lactones; D014230:Triazoles; C483518:strigol