title: Higher rate of bronchoalveolar lavage culture positivity in children with nonacid reflux and respiratory disorders.
abstract: The aim of the study was to determine if children with chronic cough or wheezing and with more full-column, nonacid reflux have a higher likelihood of a positive bronchoalveolar lavage fluid culture. In a prospective study of 46 children with cough who were undergoing endoscopy, multichannel intraluminal impedance testing, and bronchoscopy, we found that patients who had a positive culture had significantly more full-column, nonacid gastroesophageal reflux than those who had a negative culture.
authors.affiliation: Center for Motility and Functional Gastrointestinal Disorders, Children's Hospital Boston, Boston, MA 02115, USA. rachel.rosen@childrens.harvard.edu
authors.forename: Rachel
authors.initials: R
authors.lastname: Rosen
authors.forename: Nikki
authors.initials: N
authors.lastname: Johnston
authors.forename: Kristen
authors.initials: K
authors.lastname: Hart
authors.forename: Umakanth
authors.initials: U
authors.lastname: Khatwa
authors.forename: Eliot
authors.initials: E
authors.lastname: Katz
authors.forename: Samuel
authors.initials: S
authors.lastname: Nurko
mesh_terms: D000293:Adolescent; D018893:Bronchoalveolar Lavage; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D003371:Cough / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D050782:Esophageal pH Monitoring; D004941:Esophagitis / Q000453:epidemiology; D005764:Gastroesophageal Reflux / Q000453:epidemiology*; D006801:Humans; D011446:Prospective Studies; D012135:Respiratory Sounds