title: Quantitative remineralization evolution kinetics of artificially demineralized human enamel using photothermal radiometry and modulated luminescence.
abstract: Human molars were subjected to demineralization in acid gel followed by incubation in remineralization solutions without or with fluoride (1 or 1000 ppm). Photothermal radiometry (PTR) and modulated luminescence (LUM) frequency scans were performed prior to and during de/remineralization treatments. Transverse Micro-Radiography (TMR) analysis followed at treatment conclusion to determine mineral loss and lesion depth. The remineralization process illustrated a complex interplay between surface and subsurface mineral deposition, confining the thermal-wave centroid toward the dominating layer. Experimental amplitudes and phases were fitted to a coupled diffuse-photon-density-wave and thermal-wave theoretical model used to quantitatively evaluate evolving changes in thermal and optical properties of de/remineralized enamel lesions. Additional information obtained from the LUM data corroborated the remineralization kinetics affecting the PTR signals. The results pointed to enhanced effectiveness of subsurface lesion remineralization in the presence of fluoride.
authors.affiliation: Center for Advanced Diffusion-Wave Technologies, Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, ON M5S3G8, Canada.
authors.forename: Adam
authors.initials: A
authors.lastname: Hellen
authors.forename: Andreas
authors.initials: A
authors.lastname: Mandelis
authors.forename: Yoav
authors.initials: Y
authors.lastname: Finer
authors.forename: Bennett T
authors.initials: BT
authors.lastname: Amaechi
mesh_terms: D003198:Computer Simulation; D003743:Dental Enamel / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D019344:Lactic Acid / Q000494:pharmacology; D008163:Luminescent Measurements / Q000379:methods*; D008852:Microradiography / Q000379:methods; D008954:Models, Biological; D008963:Molar / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D011874:Radiometry / Q000379:methods*; D012969:Sodium Fluoride / Q000494:pharmacology / Q000627:therapeutic use; D017001:Tooth Demineralization / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D019344:Lactic Acid; D012969:Sodium Fluoride