title: Neuronal guidance: a redox signal involving Mical.
abstract: Mical, a redox enzyme, binds the cytoplasmic domain of the semaphorin receptor plexin A and mediates semaphorin-signaled collapse of the actin cytoskeleton. Recent work now shows that Mical's ability to bind actin filaments and destabilize them in a NADPH-dependent manner is responsible for semaphorin 1a's effects.
authors.affiliation: Dept. of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA. Barbara.Bernstein@ColoState.edu
authors.forename: Barbara W
authors.initials: BW
authors.lastname: Bernstein
authors.forename: James R
authors.initials: JR
authors.lastname: Bamburg
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004330:Drosophila / Q000033:anatomy & histology / Q000502:physiology; D020439:Growth Cones / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D010084:Oxidation-Reduction; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; C496247:MICAL protein, Drosophila