title: Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways.
abstract: Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.
authors.affiliation: Strathclyde Institute for Pharmacy and Biomedical Analysis, Robertson Building, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Dick
authors.forename: Neil
authors.initials: N
authors.lastname: Dooley
authors.forename: Moira A
authors.initials: MA
authors.lastname: Elliott
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Ford
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Gordon
authors.forename: Gavin W
authors.initials: GW
authors.lastname: Halbert
authors.forename: William J
authors.initials: WJ
authors.lastname: Kerr
mesh_terms: D001896:Boron Compounds / Q000032:analysis* / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004340:Drug Contamination; D004355:Drug Stability; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry
chemical_list: D001896:Boron Compounds; D010649:Phenylalanine