title: Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia.
abstract: Treatment with prescription omega-3-acid ethyl esters (POM3) reduces triglycerides (TG) and TG-rich lipoprotein particles, but has been associated with increased fasting glucose (2-6mg/dL). This double-blind, randomized, controlled crossover trial in 19 men and women with hypertriglyceridemia (fasting TG ≥150 and ≤499mg/dL) examined lipid responses and indices of insulin sensitivity and secretion following a liquid meal tolerance test. Six weeks treatment with POM3 vs. corn oil resulted in significant lower mean fasting (-50.1mg/dL, p<0.001) and postprandial TG (-76.1mg/dL, p<0.001), higher mean fasting glucose (2.8mg/dL, p=0.062), reduced mean disposition index (2.1 vs. 2.4, p=0.037), and no change in the median Matsuda composite insulin sensitivity index (3.3 vs. 3.2, p=0.959). These results suggest that POM3 slightly reduces pancreatic β-cell responsiveness to plasma glucose elevation, which may contribute to the rise in fasting glucose sometimes observed with POM3.
authors.affiliation: Provident Clinical Research/Biofortis North America, 489 Taft Avenue; Glen Ellyn, IL 60137, USA. KMaki@ProvidentCRC.com
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Maki
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Lawless
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Kelley
authors.forename: Mary R
authors.initials: MR
authors.lastname: Dicklin
authors.forename: Arianne L
authors.initials: AL
authors.lastname: Schild
authors.forename: Tia M
authors.initials: TM
authors.lastname: Rains
mesh_terms: D001786:Blood Glucose; D018592:Cross-Over Studies; D004281:Docosahexaenoic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D005215:Fasting; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000188:drug therapy*; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D055553:Prescription Drugs / Q000494:pharmacology / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008055:Lipids; D055553:Prescription Drugs; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid