title: Acute disseminated encephalomyelitis (ADEM) after pertussis infection.
abstract: Acute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating disorder of the central nervous system which is usually precipitated by a viral infection or vaccination. A 3-month-old boy is reported who developed ADEM a week after full recovery from pertussis. MRI detected a high-intensity lesion extending from the pons to the mesencephalon, compatible with ADEM. Following the administration of intravenous immunoglobulins, the patient's clinical symptoms improved. This case report demonstrates that pertussis is capable of inducing an immune-mediated demyelinating disorder of the central nervous system.
authors.affiliation: Department of Paediatric Infectious Disease, Faculty of Medicine, University of Istanbul, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Budan
authors.forename: B
authors.initials: B
authors.lastname: Ekici
authors.forename: B
authors.initials: B
authors.lastname: Tatli
authors.forename: A
authors.initials: A
authors.lastname: Somer
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography; D016896:Treatment Outcome; D014917:Whooping Cough / Q000150:complications* / Q000175:diagnosis*
chemical_list: D016756:Immunoglobulins, Intravenous