title: Evaluation of M307 of FUT1 gene as a genetic marker for disease resistance breeding of Sutai pigs.
abstract: Alpha (1,2) fucosyltransferase (FUT1) gene has been identified as a candidate gene for controlling the expression of the receptor for ETEC F18. The genetic variations in the position of M307 nucleotide in open reading frame of FUT1 have been proposed as a marker for selecting ETEC F18 resistant pigs. The polymorphisms of M307 in FUT1 of breeding base group for ETEC F18 resistance of Sutai pigs (Duroc × Meishan) was detected and their correlations to some immune indexes, growth and development ability, carcass traits and meat quality were also analyzed, which aimed to investigate feasibility of further breeding for diseases resistance based on M307 of FUT1 for Sutai pigs. After digested by Hin6 I, M307 of FUT1 gene could be divided into three kinds of genotypes, AA, AG, and GG. The frequencies were 0.235, 0.609, and 0.156, respectively. The results indicated that Sutai pigs with the AA genotype in M307 of FUT1 gene not only have relatively strong general disease resistance ability in piglets, but also have higher growth and development ability and stable carcass traits and meat quality. It is entirely feasible to raise the new strains of Sutai pigs resistant to Escherichia coli F18 based on genetic marker of the M307 position in FUT1gene.
authors.affiliation: Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Bao
authors.forename: Lan
authors.initials: L
authors.lastname: Ye
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Zhang-Yuan
authors.initials: ZY
authors.lastname: Pan
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Zhu
authors.forename: Xue-Gen
authors.initials: XG
authors.lastname: Huang
authors.forename: Sheng-Long
authors.initials: SL
authors.lastname: Wu
mesh_terms: D000818:Animals; D001947:Breeding; D060467:Disease Resistance / Q000235:genetics*; D005647:Fucosyltransferases / Q000235:genetics*; D005819:Genetic Markers; D008460:Meat / Q000592:standards; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D034421:Sus scrofa / Q000235:genetics* / Q000254:growth & development / Q000276:immunology*; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D005647:Fucosyltransferases; D005819:Genetic Markers; D000097631:Galactoside 2-alpha-L-fucosyltransferase