title: Protein evolution in cell and tissue development: going beyond sequence and transcriptional analysis.
abstract: Studies of animal evolution often focus on sequence and transcriptional analysis, based on an assumption that the evolution of development is driven by changes in gene expression. We argue that biochemical and cell biological approaches are also required, because sequence-conserved proteins can have different biochemical, cellular, and developmental properties.
authors.affiliation: Program in Cancer Biology, Stanford University, Stanford, CA 94305, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Dickinson
authors.forename: William I
authors.initials: WI
authors.lastname: Weis
authors.forename: W James
authors.initials: WJ
authors.lastname: Nelson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003585:Cell Biology; D015509:Developmental Biology; D019143:Evolution, Molecular; D005786:Gene Expression Regulation / Q000235:genetics; D023421:Models, Animal; D011506:Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D011506:Proteins