title: Tandem Cycloisomerization/Suzuki Coupling of Arylethynyl MIDA Boronates.
abstract: A tandem gold-catalyzed cycloisomerization/Suzuki cross coupling sequence involving arylethynyl-N-methyliminodiacetic acid boronates is described. Combining the mildness of homogeneous gold catalysis with the versatility of N-methyliminodiacetic acid (MIDA) boronates, this tandem two-step method enables the rapid assembly of various aryl-substituted heterocycles without having to isolate or purify any heterocyclic MIDA boronate intermediates. Another major advantage of this method is that a wide range of heterocycles bearing different aryl groups may be made from a single MIDA boronate alkyne precursor.
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720, United States.
authors.forename: Julian M W
authors.initials: JM
authors.lastname: Chan
authors.forename: Giovanni W
authors.initials: GW
authors.lastname: Amarante
authors.forename: F Dean
authors.initials: FD
authors.lastname: Toste