title: Outcomes of patients with maxillofacial osteosarcoma: a review of 15 cases.
abstract: OBJECTIVE
  To assess clinical behavior, response to treatment, and factors affecting survival in maxillofacial osteosarcoma treated at a tertiary referral center.
  
  
  METHODS
  Ethics-approved retrospective review of clinical and pathological records was undertaken for 15 patients managed by the Royal Melbourne Hospital Head and Neck Oncology Tumor Stream.
  
  
  RESULTS
  Treatment was a combination of surgery and chemotherapy. Chemotherapy was given as adjuvant, neoadjuvant, or in combination. The overall 2-, 5-, and 15-year disease-free survival rates in this study were 92%, 74%, and 74%, respectively. Using Kaplan-Meier analysis with log rank tests, increasing T stage (P = .01) and positive margins (P = .003) were found to affect survival significantly. Neoadjuvant chemotherapy was not significantly associated with tumor necrosis or improved survival.
  
  
  CONCLUSIONS
  Tumor size and adequacy of local control were found to be the most important predictors of outcome.
authors.affiliation: Head, Neck Oncology Tumour Stream, Department of Surgery, Royal Melbourne Hospital, Parkville, Victoria, Australia.
authors.forename: Adrian F
authors.initials: AF
authors.lastname: DeAngelis
authors.forename: Catherine
authors.initials: C
authors.lastname: Spinou
authors.forename: Alpha
authors.initials: A
authors.lastname: Tsui
authors.forename: Tim
authors.initials: T
authors.lastname: Iseli
authors.forename: Jayesh
authors.initials: J
authors.lastname: Desai
authors.forename: David
authors.initials: D
authors.lastname: Wiesenfeld
authors.forename: Arun
authors.initials: A
authors.lastname: Chandu
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D008441:Maxillary Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D012516:Osteosarcoma / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D017063:Outcome Assessment, Health Care; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D055815:Young Adult