title: The CYBA gene A640G polymorphism influences predispositions to coronary artery disease through interactions with cigarette smoking and hypercholesterolemia.
abstract: The CYBA gene encodes the p22phox peptide, an essential subunit of vascular NADPH oxidases. The aim of the study was to analyze potential interactions between CYBA gene A640G polymorphism and traditional risk factors of atherosclerosis. We studied 320 subjects: 160 patients with coronary artery disease (CAD) and 160 controls. The results of interactions were interpreted on the basis of synergy index values (SI, SIM). The 640G allele interacted with cigarette smoking (SI = 2.02, SIM = 2.32). Even greater increase of the CAD risk was found whenever the 640G allele interacted with both smoking and hypercholesterolemia (SI = 2.70, SIM = 3.60). The results suggest that the A640G polymorphism may influence individual predispositions to CAD through interactions with smoking and hypercholesterolemia.
authors.affiliation: Department of Biochemistry and Medical Genetics, Medical University of Silesia, School of Health Care, Katowice, Poland. pniemiec@sum.edu.pl
authors.forename: Pawel
authors.initials: P
authors.lastname: Niemiec
authors.forename: Tomasz
authors.initials: T
authors.lastname: Nowak
authors.forename: Anna
authors.initials: A
authors.lastname: Balcerzyk
authors.forename: Jolanta
authors.initials: J
authors.lastname: Krauze
authors.forename: Iwona
authors.initials: I
authors.lastname: Zak
mesh_terms: D000328:Adult; D000483:Alleles; D003324:Coronary Artery Disease / Q000150:complications / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking; D014026:Nicotiana
chemical_list: D019255:NADPH Oxidases; C086986:CYBA protein, human