title: [Effect of alendronate sodium on torque-out testing on implant-bone interfaces in estrogen-deficient rabbits with alendronate systemic administration].
abstract: OBJECTIVE
  To investigate the influence of systemic application of Alendronate sodium, a bone resorption inhibitor, on the osseointegration of implant-bone interface in estrogen-deficient rabbits through mechanical assessment.
  
  
  METHODS
  27 five-month-old Japanese white female rabbits were randomly divided into three groups (9 rabbits each group). An ovariectomy group (OVX), an ovariectomy and Alendronate sodium group (ALN) and a shamed-operated group (S). 12 weeks after operation, implants were installed into bilateral distal femurs and proximal tibias in each group. Alendronate sodium was administrated by intraperitoneal injection in ALN group; meanwhile equivalent of normal saline was administrated by intraperitoneal injection in OVX group and S group. Bone mineral density was measured right after the implant operation and also in 4, 8, 12 weeks. Torque-out values were measured in 4, 8, 12 weeks after animal sacrifice.
  
  
  RESULTS
  Bone mineral density of tibias in ALN group was closed to S group and was significantly different from OVX group (P < 0.05) after 8 weeks. While after 12 weeks, the bone mineral density of tibias and femurs in ALN group was both closed to S group and was significantly different from OVX group (P < 0.05). The torque-out values of tibias in ALN group were closed to S group and were significantly different from OVX group (P < 0.05) after 8 weeks. After 12 weeks, the torque-out values of tibias and femurs in ALN group were both closed to S group and were significantly different from OVX group (P < 0.05).
  
  
  CONCLUSIONS
  Systemic application of Alendronate sodium in osteoporosis rabbits can improve the bone-implant osseointegration significantly.
authors.affiliation: Implant Center, Stomatological Hospital of Jilin University, Changchun 130021, China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Li
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Zhou
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Fu
authors.forename: Lin
authors.initials: L
authors.lastname: Gong
mesh_terms: D019386:Alendronate; D000818:Animals; D015519:Bone Density; D050071:Bone Density Conservation Agents; D001842:Bone and Bones; D004967:Estrogens; D005260:Female; D016348:Osseointegration; D010024:Osteoporosis; D010052:Ovariectomy; D019736:Prostheses and Implants; D011817:Rabbits; D019415:Torque
chemical_list: D050071:Bone Density Conservation Agents; D004967:Estrogens; D019386:Alendronate