title: Antidepressant-like effect of aqueous extract of Channa striatus fillet in mice models of depression.
abstract: OBJECTIVE
  Channa (C.) striatus (Malay-Haruan), is a fresh water snakehead fish, consumed as a rejuvenating diet in post-parturition period in local Malay population. The aqueous extract of C. striatus fillet (AECSF) was reported to act through serotonergic receptor system in a previous study. There is no scientific report on neuropharmacological effects of C. striatus. Based on these data, the antidepressant-like effect of C. striatus was evaluated in mice models of depression.
  
  
  METHODS
  AECSF was prepared by steaming the fillets as described previously. Antidepressant activity was studied in male ICR mice using forced swimming test (FST) and tail suspension test (TST). Open-field test was used to evaluate any psychomotor stimulant activity. AECSF was administered intraperitoneally at the concentrations of 30%, 40% and 50% w/v at the dosage of 10 ml/kg. Amitriptyline (10 mg/kg) was used as positive control.
  
  
  RESULTS
  All the three concentrations of AECSF (30%, 40% and 50% w/v) significantly reduced the immobility time (p < 0.001) in FST and TST. All the three concentrations of AECSF (30%, 40% and 50% w/v) significantly (p < 0.001) reduced locomotor activity in a dose-dependent manner in open-field test.
  
  
  CONCLUSIONS
  AECSF produced significant reduction of immobility time in both FST and TST. Amitriptyline produced a significant reduction of immobility time in both FST and TST similar to previous findings. The AECSF produced a dose-dependent decrease in locomotor activity in the open-field test. This hypolocomotion effect indicated the absence of any psychomotor stimulant activity thereby supporting the antidepressant-like effect of the AECSF. The pharmacological mechanisms of the observed antidepressant-like effect and hypolocomotion effect are not understood from our study. Hence, further studies are required.
authors.affiliation: Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, Selangor, Malaysia.
authors.forename: A M
authors.initials: AM
authors.lastname: Saleem
authors.forename: M
authors.initials: M
authors.lastname: Taufik Hidayat
authors.forename: A M
authors.initials: AM
authors.lastname: Mat Jais
authors.forename: S
authors.initials: S
authors.lastname: Fakurazi
authors.forename: Mohamad
authors.initials: M
authors.lastname: Moklas
authors.forename: M R
authors.initials: MR
authors.lastname: Sulaiman
authors.forename: Z
authors.initials: Z
authors.lastname: Amom
mesh_terms: D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005396:Fish Products; D005618:Fresh Water; D019417:Hindlimb Suspension; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D010473:Perciformes; D013550:Swimming; D013997:Time Factors; D014020:Tissue Extracts / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D014020:Tissue Extracts; D000639:Amitriptyline