title: A microchip-based model wound with multiple types of cells.
abstract: Collective migration is critical to many physiological processes, but few methods allow for studying this behavior with precisely controlled cell-cell interaction. Here we report the development of a microchip based on co-culture of different types of cells and selective injury, and explore the dynamics of epithelial collective migration triggered by a real cell group.
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 BeiYiTiao, ZhongGuanCun, Beijing, 100190, China.
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Xie
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.forename: Kang
authors.initials: K
authors.lastname: Sun
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Xingyu
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000818:Animals; D002460:Cell Line; D002465:Cell Movement; D049109:Cell Proliferation; D018920:Coculture Techniques; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D004285:Dogs; D056656:Lab-On-A-Chip Devices; D051379:Mice; D046208:Microchip Analytical Procedures / Q000379:methods; D008954:Models, Biological; D014945:Wound Healing
chemical_list: D004129:Dimethylpolysiloxanes; C013830:baysilon