title: Uterine cervical carcinomas associated with lobular endocervical glandular hyperplasia.
abstract: OBJECTIVE
  To investigate the clinicopathological features of cervical uterine carcinoma associated with lobular endocervical glandular hyperplasia (LEGH).
  
  
  RESULTS
  Subjects comprised 12 patients with cervical carcinoma associated with LEGH. Carcinoma included nine invasive adenocarcinomas, two adenocarcinoma in-situ (AIS) and one microinvasive squamous cell carcinoma (SCC). Baseline characteristics, cervical cytology, human papilloma virus (HPV) status, immunohistochemistry, surgical procedures and clinical outcomes were investigated. There was a pair of adenocarcinoma cases in a mother and daughter unrelated to Peutz-Jeghers syndrome. In all patients, atypical cells were seen on cervical cytology (adenocarcinoma cells in 11 cases and SCC cells in one). All the 12 patients were positive for mucin antigen 6 (MUC6) in the LEGH component, while seven patients were positive for gastric mucin (HIK1083). HPV was detected only in the SCC component. One patient with adenocarcinoma stage Ib died of disease 4 years after radical hysterectomy. The others are currently alive 2-16 years postoperatively.
  
  
  CONCLUSIONS
  The diagnosis of adenocarcinoma with LEGH is not always difficult. The prognosis of adenocarcinoma associated with LEGH may be better than previously expected. Adenocarcinoma with a LEGH component does not always develop into a highly aggressive minimal deviation adenocarcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. tsujita@m3.kufm.kagoshima-u.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuji
authors.forename: Shinichi
authors.initials: S
authors.lastname: Togami
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Nomoto
authors.forename: Michiyo
authors.initials: M
authors.lastname: Higashi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Fukukura
authors.forename: Masaki
authors.initials: M
authors.lastname: Kamio
authors.forename: Suguru
authors.initials: S
authors.lastname: Yonezawa
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Douchi
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000821:virology; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000378:metabolism / Q000473:pathology / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005752:Gastric Mucins / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008875:Middle Aged; D055272:Mucin-6 / Q000378:metabolism; D009361:Neoplasm Invasiveness / Q000473:pathology; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000821:virology
chemical_list: D015344:DNA Probes, HPV; D004279:DNA, Viral; D005752:Gastric Mucins; C524734:MUC6 protein, human; D055272:Mucin-6