title: Clues to the foundations of numerical cognitive impairments: evidence from genetic disorders.
abstract: Several neurodevelopmental disorders of known genetic etiology generate phenotypes that share the characteristic of numerical and mathematical cognitive impairments. This article reviews some of the main findings that suggest a possible key role that spatial and temporal information processing impairments may play in the atypical development of numerical cognitive competence. The question of what neural substrate might underlie these impairments is also addressed, as are the challenges for interpreting neural structure/cognitive function mapping in atypically developing populations.
authors.affiliation: MIND Institute, University of California Davis, Sacramento, California 95817, USA. tjsimon@ucdavis.edu
authors.forename: Tony J
authors.initials: TJ
authors.lastname: Simon
mesh_terms: D001288:Attention / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology* / Q000503:physiopathology*; D001931:Brain Mapping / Q000523:psychology; D003072:Cognition Disorders / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D055641:Mathematical Concepts; D013028:Space Perception / Q000502:physiology; D013998:Time Perception / Q000502:physiology; D014796:Visual Perception / Q000502:physiology