title: Reversible redox of NADH and NAD+ at a hybrid lipid bilayer membrane using ubiquinone.
abstract: Here, we report the reversible interconversion between NADH and NAD(+) at a low overpotential, which is in part mediated by ubiquinone embedded in a biomimetic membrane to mimic the initial stages of respiration. This system can be used as a platform to examine biologically relevant electroactive molecules embedded in a natural membrane environment and provide new insights into the mechanism of biological redox cycling.
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry and Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Li
authors.forename: Todd C
authors.initials: TC
authors.lastname: Sutherland
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Long
authors.forename: Hong-Yuan
authors.initials: HY
authors.lastname: Chen
mesh_terms: D008051:Lipid Bilayers / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D010084:Oxidation-Reduction; D014451:Ubiquinone / Q000378:metabolism*
chemical_list: D008051:Lipid Bilayers; D009243:NAD; D014451:Ubiquinone