title: Nanoscale studies of protein-membrane interactions in blood clotting.
abstract: Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.
authors.affiliation: Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. jhmorris@illinois.edu
authors.forename: J H
authors.initials: JH
authors.lastname: Morrissey
authors.forename: E
authors.initials: E
authors.lastname: Tajkhorshid
authors.forename: C M
authors.initials: CM
authors.lastname: Rienstra
mesh_terms: D001777:Blood Coagulation; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D036103:Nanotechnology; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins