title: [Correlation study between Chinese myasthenia gravis patients from Guangdong province and the polymorphism of HLA immunogene].
abstract: OBJECTIVE
  To explore the correlation between Chinese myasthenia gravis (MG) patients from Guangdong province and the polymorphism of HLA immunogene.
  
  
  METHODS
  The genotypes of HLA-A, B and DRB1 alleles in 104 MG patients and 121 healthy blood donors were detected by PCR-SBT (polymerase chain reaction-sequencing-based typing).
  
  
  RESULTS
  (1) There were 15 alleles at A locus, 32 at B locus and 23 at DRB1 locus in MG group. (2) The frequency of HLA-A*02:07(P = 0.000, RR = 3.715), -B*46:01(P = 0.000, RR = 5.698), -DRB1*04:03(P = 0.033, RR = 6.312), -DRB1*09:01(P = 0.000, RR = 5.884) in MG patients was higher than that in healthy controls. (3) There were positive associations of HLA-DRB1*09:01(P = 0.000, RR = 1.349) with juvenile-onset ocular MG.
  
  
  CONCLUSIONS
  There is susceptibility association of HLA-A*02:07, -B*46:01, -DRB1*04:03, -DRB1*09:01 with Chinese MG patients from Guangdong province. There is a close genetic and immunological correlation between HLA alleles and the pathogenesis of MG. It has directional significance in the race and region incidence study, clinical classification, differential diagnosis, treatment and prognosis of MG.
authors.affiliation: Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Hui-yu
authors.initials: HY
authors.lastname: Feng
authors.forename: Min
authors.initials: M
authors.lastname: Luo
authors.forename: Wei-bin
authors.initials: WB
authors.lastname: Liu
authors.forename: Lu-lu
authors.initials: LL
authors.lastname: Xiao
authors.forename: Li
authors.initials: L
authors.lastname: Qiu
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.forename: Ru-xun
authors.initials: RX
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059811:HLA-DRB1 Chains