title: [Protective effects of shaoganduogan on hepatocyte mitochondria in subacute liver injury rat induced by carbon tetrachloride].
abstract: OBJECTIVE
  To study the protective effect of Shaoganduogan (SGDG) on serum transaminase, liver pathology and hepatocyte mitochondria in rat with subacute liver injury induced by carbon tetrachloride.
  
  
  METHODS
  Subacute liver injury of rats were induced by carbon tetrachloride, and cured by different doses of SGDG through intragastric administration. The activity of serum ALT, AST, liver pathology and ultrastructure, activity of ATPase, SOD and content of MDA of hepatocyte mitochondria were observed.
  
  
  RESULTS
  SGDG can remarkably reduce the transaminase, alleviate the degeneration and necrosis of liver cells ,enhance activity of Na+ -K+ ATPase, Ca2+ ATPase, SOD, reduce content of MDA of mitochondria, alleviate ultrastructure change of mitochondria, reduce section area, perimeter equivalent diameter and average optical density perimeter of liver cells.
  
  
  CONCLUSIONS
  SGDG has obvious effect of liver protection, the mechanisms are related with alleviating mitochondria injury.
authors.affiliation: Institute of Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Science, Key Laboratory of Biological Evaluation of Traditional Chinese Medicine Quality of the State Administration of Traditional Chinese Medicine, Key Laboratory of Evaluation of Chinese Herbal Quality of Sichuan Province, Chendu 610041, China. sccdsj70@qq.com
authors.forename: Jun
authors.initials: J
authors.lastname: Song
authors.forename: Junning
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Dai
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Deng
authors.forename: Jinhai
authors.initials: J
authors.lastname: Yi
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D002251:Carbon Tetrachloride