title: Correlation of atherogenetic biomarkers and estradiol changes in postmenopause.
abstract: In postmenopausal women there is age-related sudden decrease in estrogen level. Consequently, at this age in women there are frequent metabolic abnormalities, life quality deterioration, and sudden increase of cardiovascular diseases, high morbidity risk, which together with these risk-factors are related to changes of hormonal status. Research goal was to determine age-dependent changes of diagnostically significant parameters (lipid, fibrinogen, C reactive protein, estradiol content, activity of antioxidant enzymes) in the blood of patients in atherosclerosis-induced cardiovascular disease. Two age groups (<45 and >45) of women with atherosclerosis-induced diseases was selected for the research. It was found, that in menopausal period a number of parameters of lipid and antioxidant metabolism are subject to hormone (estrogen)-dependent changes. In particular, in postmenopausal women the increase in content of total cholesterol, triglycerides, LDL and fibrinogen, the decrease in HDL take place that leads to estrogen-dependent dyslipidemia. Age-dependent deficiency of estradiol and glutathione with antioxidant activity in blood of postmenopausal women causes compensatory activity of catalase, which is not always enough. The mentioned increases the risk of the development of cardiovascular diseases in postmenopausal women. If cardiovascular morbidity rate is particularly high in male individuals versus premenopausal females, in a postmenopausal period this difference is not so distinguished due to the alterations in hormonal status.
authors.affiliation: Tbilisi State Medical University, Life Science Research Center, Tbilisi, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Ratiani
authors.forename: G
authors.initials: G
authors.lastname: Parkosadze
authors.forename: L
authors.initials: L
authors.lastname: Koptonashvili
authors.forename: G
authors.initials: G
authors.lastname: Ormotsadze
authors.forename: M
authors.initials: M
authors.lastname: Sulaqvelidze
authors.forename: T
authors.initials: T
authors.lastname: Sanikidze
mesh_terms: D000328:Adult; D000367:Age Factors; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology; D002374:Catalase / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004958:Estradiol / Q000097:blood / Q000378:metabolism*; D004967:Estrogens / Q000097:blood / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood / Q000378:metabolism*; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D004967:Estrogens; D014280:Triglycerides; D004958:Estradiol; D005340:Fibrinogen; D002097:C-Reactive Protein; D002784:Cholesterol; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase