title: [Glutaminergic neurons expressing c-Fos in the brainstem and amygdala participate in signal transmission and integration of sweet taste].
abstract: OBJECTIVE
  To examine the role of glutaminergic neurons in the transmission and integration of the sweat taste information in the brain stem and the amygdala.
  
  
  METHODS
  Conscious Sprague-Dawley rats were subjected to oral sweet taste or water (control) stimulations. The activated neurons were identified by detecting c-Fos expression in taste-related brain areas, and the glutaminergic neurons by detecting vesicular glutamate transpoter-3 (VGLUT3).
  
  
  RESULTS
  Compared with control group, the rats with oral sucrose solution stimulation exhibited significantly increased c-Fos-expressing and double-labeled neurons in the nucleus of the solitary tract (NST), the parabrachial nucleus (PBN) and the amygdala.
  
  
  CONCLUSIONS
  Neurons in the NST, PBN and amygdala are activated after oral sweet taste stimulation. The sweet taste perception at different levels in the CNS is partly mediated by glutamate.
authors.affiliation: Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China. zhaoxiaolin0728@gmail.com
authors.forename: Xiao-lin
authors.initials: XL
authors.lastname: Zhao
authors.forename: Jian-qun
authors.initials: JQ
authors.lastname: Yan
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.forename: Xue-juan
authors.initials: XJ
authors.lastname: Yang
authors.forename: Jin-rong
authors.initials: JR
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D017552:Solitary Nucleus / Q000166:cytology / Q000502:physiology; D013395:Sucrose / Q000008:administration & dosage / Q000378:metabolism; D055697:Taste Perception / Q000502:physiology*; D050496:Vesicular Glutamate Transport Proteins / Q000378:metabolism
chemical_list: D016760:Proto-Oncogene Proteins c-fos; C482103:Slc17a8 protein, rat; D050496:Vesicular Glutamate Transport Proteins; D018698:Glutamic Acid; D013395:Sucrose