title: Effects of perinatal exposure to bisphenol A on the behavior of offspring in F344 rats.
abstract: The objective of this investigation is to evaluate whether perinatal maternal exposure to bisphenol A (BPA) at 4, 40, and 400 mg/kg per day affects the behavior of offspring in F344 rats. Perinatal BPA exposure inhibited the body weight increases of male and female offspring in a dose-dependent manner, which continued after weaning. Spontaneous activity analyses revealed that BPA elongated immobile time during the dark phase in female offspring. At 4 weeks of age, male offspring exposed to BPA at 40 and 400 mg/kg per day performed avoidance responses significantly higher in the shuttlebox avoidance test. At 8 weeks of age, however, male offspring only at 4 mg/kg per day showed significantly lower responses. In the open-field behavior test at 8 weeks of age, male offspring exposed to BPA only at 4 mg/kg per day showed a higher percent of grooming than the control male offspring. In conclusion, perinatal exposure to BPA caused the behavioral alterations in the offspring.
authors.affiliation: Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan; CREST, Japan Science and Technology Corporation, Kawaguchi-shi, Saitama 332-0012, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Negishi
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takatori
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ishii
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kyuwa
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshikawa