title: Nuclear factor I/B is an oncogene in small cell lung cancer.
abstract: Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.
authors.affiliation: David H. Koch Institute for Integrative Cancer Research,Department of Biology, Massachusetts Institute of Technology, Cambridge, USA.
authors.forename: Alison L
authors.initials: AL
authors.lastname: Dooley
authors.forename: Monte M
authors.initials: MM
authors.lastname: Winslow
authors.forename: Derek Y
authors.initials: DY
authors.lastname: Chiang
authors.forename: Shantanu
authors.initials: S
authors.lastname: Banerji
authors.forename: Nicolas
authors.initials: N
authors.lastname: Stransky
authors.forename: Talya L
authors.initials: TL
authors.lastname: Dayton
authors.forename: Eric L
authors.initials: EL
authors.lastname: Snyder
authors.forename: Stephanie
authors.initials: S
authors.lastname: Senna
authors.forename: Charles A
authors.initials: CA
authors.lastname: Whittaker
authors.forename: Roderick T
authors.initials: RT
authors.lastname: Bronson
authors.forename: Denise
authors.initials: D
authors.lastname: Crowley
authors.forename: Jordi
authors.initials: J
authors.lastname: Barretina
authors.forename: Levi
authors.initials: L
authors.lastname: Garraway
authors.forename: Matthew
authors.initials: M
authors.lastname: Meyerson
authors.forename: Tyler
authors.initials: T
authors.lastname: Jacks
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D051839:NFI Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D009857:Oncogenes / Q000235:genetics / Q000502:physiology*; D055752:Small Cell Lung Carcinoma / Q000235:genetics*
chemical_list: D051839:NFI Transcription Factors