title: Congenital cytomegalovirus infection manifesting as neonatal persistent pulmonary hypertension: report of two cases.
abstract: Various neonatal symptoms can lead to a diagnosis of congenital CMV infection. We report two cases of persistent pulmonary hypertension in relation with congenital CMV infection following maternal primary infection and reinfection, respectively. Both infants had severe refractory hypoxemia, requiring high-frequency ventilation, inhaled nitric oxide and inotropic support. One of them required extracorporeal membrane oxygenation for five days. Ganciclovir therapy was attempted in the two cases on day 12 postnatal. One of the infant died on day 15 postnatal. The other survived and is developing uneventfully at 15 months of age.
  
  
  CONCLUSIONS
  Neonatal persistent pulmonary hypertension can be the consequence of congenital CMV infection. Intensive respiratory support and IV ganciclovir are indicated in case of life-threatening condition.
authors.affiliation: Service de Néonatologie, Hôpital Armand Trousseau, AP-HP, Faculté de Médecine, Université Pierre et Marie Curie, 75012 Paris, France.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Walter-Nicolet
authors.forename: Magali
authors.initials: M
authors.lastname: Leblanc
authors.forename: Marianne
authors.initials: M
authors.lastname: Leruez-Ville
authors.forename: Philippe
authors.initials: P
authors.lastname: Hubert
authors.forename: Delphine
authors.initials: D
authors.lastname: Mitanchez