title: Motor-evoked potential confirmation of functional improvement by transplanted bone marrow mesenchymal stem cell in the ischemic rat brain.
abstract: This study investigated the effect of bone marrow mesenchymal stem cells (BMSCs) on the motor pathway in the transient ischemic rat brain that were transplanted through the carotid artery, measuring motor-evoked potential (MEP) in the four limbs muscle and the atlantooccipital membrane, which was elicited after monopolar and bipolar transcortical stimulation. After monopolar stimulation, the latency of MEP was significantly prolonged, and the amplitude was less reduced in the BMSC group in comparison with the control group (P < .05). MEPs induced by bipolar stimulation in the left forelimb could be measured in 40% of the BMSC group and the I wave that was not detected in the control group was also detected in 40% of the BMSC group. Our preliminary results imply that BMSCs transplanted to the ischemic rat brain mediate effects on the functional recovery of the cerebral motor cortex and the motor pathway.
authors.affiliation: Institute of Catholic Integrative Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon 403-720, Republic of Korea.
authors.forename: Dong-Kyu
authors.initials: DK
authors.lastname: Jang
authors.forename: Sang-In
authors.initials: SI
authors.lastname: Park
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Han
authors.forename: Kyung-Sool
authors.initials: KS
authors.lastname: Jang
authors.forename: Moon-Seo
authors.initials: MS
authors.lastname: Park
authors.forename: Young-An
authors.initials: YA
authors.lastname: Chung
authors.forename: Min-Wook
authors.initials: MW
authors.lastname: Kim
authors.forename: Lee-So
authors.initials: LS
authors.lastname: Maeng
authors.forename: Pil-Woo
authors.initials: PW
authors.lastname: Huh
authors.forename: Do-Sung
authors.initials: DS
authors.lastname: Yoo
authors.forename: Seong-Whan
authors.initials: SW
authors.lastname: Jung
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001854:Bone Marrow Cells / Q000166:cytology; D020520:Brain Infarction / Q000503:physiopathology / Q000628:therapy*; D046690:Deep Brain Stimulation; D019054:Evoked Potentials, Motor / Q000502:physiology*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology; D009930:Organic Chemicals / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009930:Organic Chemicals; C070080:PKH 26