title: Viral molecular characterization of the first congenital rubella syndrome case in Vietnam.
abstract: BACKGROUND
  Rubella virus (RV) infection during the first trimester of pregnancy often leads to severe birth defects known as congenital rubella syndrome (CRS).
  
  
  METHODS
  A premature newborn male was clinically diagnosed as CRS with cataracts, congenital heart defects, microcephaly, hepatosplenomegaly, and thrombocytopenia. The infection was confirmed serologically and molecularly.
  
  
  RESULTS
  The RV was characterized and clustered with the 2B genotype.
  
  
  CONCLUSIONS
  The integrated description of clinical features, serological and molecular data provide a baseline for diagnosis and control of rubella and CRS in Vietnam. This is the first report of molecular investigation of wildtype RV strain in Vietnam, thus contributing to the documentation of RV's worldwide distribution.
authors.affiliation: Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Dinh Nguyen
authors.initials: DN
authors.lastname: Tran
authors.forename: Minh Phuc
authors.initials: MP
authors.lastname: Vu
authors.forename: Manh Tuan
authors.initials: MT
authors.lastname: Ha
authors.forename: Tran Phuong Linh
authors.initials: TP
authors.lastname: Giang
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Komase
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizuguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ushijima
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology* / Q000821:virology; D000328:Adult; D002386:Cataract / Q000151:congenital / Q000209:etiology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006330:Heart Defects, Congenital / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000821:virology*; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008831:Microcephaly / Q000209:etiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D011261:Pregnancy Trimester, First; D012409:Rubella / Q000151:congenital* / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D012412:Rubella virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D014744:Vietnam / Q000453:epidemiology
chemical_list: D004279:DNA, Viral