title: Serum testosterone levels significantly correlate with nocturia in men aged 40-79 years.
abstract: OBJECTIVE
  To investigate the association between serum sex hormone levels and lower urinary tract symptoms in men aged 40-79 years.
  
  
  METHODS
  A cross-sectional study was conducted in 509 men (mean age 58 years). The serum total testosterone (TT), dihydrotestosterone, and estradiol levels were measured. The total prostate volume measured by transrectal ultrasonography and International Prostate Symptom Score (IPSS) questionnaire were obtained. Correlations were determined using univariate and multivariate regression analysis.
  
  
  RESULTS
  The subjects with moderate to severe lower urinary tract symptoms (total IPSS≥8) were older, with a greater incidence of hypertension and diabetes, a larger prostate, and had lower serum TT levels. On the univariate analysis, the serum TT levels were negatively associated with the total IPSS, IPSS storage subscore, weak stream, and nocturia. After adjusting for age, hypertension, diabetes, and total prostate volume, only the serum TT level was significantly associated with nocturia (>2 times/night; P=.042), and men with serum TT levels in the greatest quartile had a 44% reduced risk of nocturia than in the lowest quartile (P=.037).
  
  
  CONCLUSIONS
  In our relative healthy male cohort, most IPSS items showed no significant association with serum sex hormone levels, except for nocturia, which showed a negative correlation with the serum testosterone level.
authors.affiliation: Division of Urology, Department of Surgery, Cardinal Tien Hospital, and Graduate Institute of Basic Medicine, Fu Jen Catholic University College of Medicine, Taipei, Taiwan.
authors.forename: Chun-Hou
authors.initials: CH
authors.lastname: Liao
authors.forename: Han-Sun
authors.initials: HS
authors.lastname: Chiang
authors.forename: Hong-Jeng
authors.initials: HJ
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D013196:Dihydrotestosterone / Q000097:blood; D004958:Estradiol / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000097:blood*; D011467:Prostate / Q000000981:diagnostic imaging; D011470:Prostatic Hyperplasia / Q000150:complications / Q000000981:diagnostic imaging; D013739:Testosterone / Q000097:blood*; D014463:Ultrasonography; D014555:Urination Disorders / Q000097:blood / Q000209:etiology
chemical_list: D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol