title: Genetic variants and the metabolic syndrome: a systematic review.
abstract: Several candidate gene studies on the metabolic syndrome (MetS) have been conducted. However, for most single nucleotide polymorphisms (SNPs) no systematic review on their association with MetS exists. A systematic electronic literature search was conducted until the 2nd of June 2010, using HuGE Navigator. English language articles were selected. Only genes of which at least one SNP-MetS association was studied in an accumulative total population ≥ 4000 subjects were included. Meta-analyses were conducted on SNPs with three or more studies available in a generally healthy population. In total 88 studies on 25 genes were reviewed. Additionally, for nine SNPs in seven genes (GNB3, PPARG, TCF7L2, APOA5, APOC3, APOE, CETP) a meta-analysis was conducted. The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. After having systematically reviewed the most studied SNP-MetS associations, we found evidence for an association with the MetS for eight SNPs, mostly located in genes involved in lipid metabolism.
authors.affiliation: National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. cecile.povel@rivm.nl
authors.forename: C M
authors.initials: CM
authors.lastname: Povel
authors.forename: J M A
authors.initials: JM
authors.lastname: Boer
authors.forename: E
authors.initials: E
authors.lastname: Reiling
authors.forename: E J M
authors.initials: EJ
authors.lastname: Feskens
mesh_terms: D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D024821:Metabolic Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics