title: Polymers in small-interfering RNA delivery.
abstract: This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers-containing different nanoparticles. The article will provide a brief and concise account of underlying principle of these polymeric vectors and their structural and functional modifications which were intended to serve different purposes to affect efficient therapeutic outcome of small-interfering RNA delivery. The modifications of these polymeric vectors will be discussed with reference to stimuli-responsiveness, target specific delivery, and incorporation of nanoconstructs such as carbon nanotubes, gold nanoparticles, and silica nanoparticles. The emergence of small-interfering RNA as the potential therapeutic agent and its mode of action will also be mentioned in a nutshell.
authors.affiliation: Department of Chemistry, BK School of Molecular Science, Polymer Research Institute, Pohang University of Science and Technology, Pohang, Korea.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Singha
authors.forename: Ran
authors.initials: R
authors.lastname: Namgung
authors.forename: Won Jong
authors.initials: WJ
authors.lastname: Kim
mesh_terms: D002482:Cellulose / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry; D020868:Gene Silencing; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry* / Q000378:metabolism; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000235:genetics; D014162:Transfection / Q000379:methods*
chemical_list: D003505:Cyclodextrins; D050091:Dendrimers; D037742:Nanotubes, Carbon; D010455:Peptides; D011108:Polymers; D034741:RNA, Small Interfering; C041953:cyclodextrin polymer; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011094:Polyethyleneimine; D002482:Cellulose; D048271:Chitosan