title: Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo.
abstract: WNT signaling activity is involved in the regulation of many cellular functions, including proliferation, migration, cell fate specification, maintenance of pluripotency and induction of tumorigenicity. Here we summarize recent progress towards understanding the regulation of canonical WNT/β-catenin signaling activity through feedback regulatory loops involving the ligands, agonists and antagonists, the availability of intracellular pools of active β-catenin and the cross-regulation of the WNT activity by β-catenin independent pathway. We also review recent findings on the role of WNT/β-catenin signaling in tissue lineage differentiation during embryogenesis and the maintenance and self renewal of embryo-derived stem cells in vitro.
authors.affiliation: Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan. stanaka@kumamoto-u.ac.jp;
authors.forename: Satomi S
authors.initials: SS
authors.lastname: Tanaka
authors.forename: Yoji
authors.initials: Y
authors.lastname: Kojima
authors.forename: Yasuka L
authors.initials: YL
authors.lastname: Yamaguchi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Nishinakamura
authors.forename: Patrick P L
authors.initials: PP
authors.lastname: Tam
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D002465:Cell Movement; D004622:Embryo, Mammalian / Q000166:cytology* / Q000378:metabolism; D047108:Embryonic Development; D053595:Embryonic Stem Cells / Q000166:cytology; D051157:Frizzled Receptors / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D005855:Germ Layers / Q000166:cytology / Q000196:embryology; D053673:Glypicans / Q000378:metabolism; D006321:Heart / Q000196:embryology / Q000254:growth & development; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D051379:Mice; D010641:Phenotype; D055748:SOXB1 Transcription Factors / Q000235:genetics / Q000378:metabolism; D051153:Wnt Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051157:Frizzled Receptors; D053673:Glypicans; D019812:Heparan Sulfate Proteoglycans; D036341:Intercellular Signaling Peptides and Proteins; D055748:SOXB1 Transcription Factors; D051153:Wnt Proteins; D051176:beta Catenin; C495267:CTNNB1 protein, mouse; C501127:Dkk1 protein, mouse; C115814:Gpc4 protein, mouse; C501209:Gpc5 protein, mouse; C527783:Sox2 protein, mouse; C075668:Tcf3 protein, mouse