title: Synthesis and in-vitro anti-inflammatory activity of novel glycodendrimers with benzene 1,3,5 carboxamide core and triazole as branching unit.
abstract: Novel glycodendrimers scaffolds containing twelve and eighteen α-D-glycopyranoside at the periphery and triazole as branching unit have been synthesized using click chemistry. Higher generation dendrimers exhibit better anti-inflammatory activity than the lower generation due to the presence of more triazole branching units and multivalent glycopyranoside units.
authors.affiliation: Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu, India.
authors.forename: Perumal
authors.initials: P
authors.lastname: Rajakumar
authors.forename: Ramasamy
authors.initials: R
authors.lastname: Anandhan
mesh_terms: D000577:Amides / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001554:Benzene / Q000737:chemistry*; D002240:Carbohydrate Sequence; D050091:Dendrimers; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000577:Amides; D000893:Anti-Inflammatory Agents; D050091:Dendrimers; D001554:Benzene