title: Tableting technology from the individual and new galenic alkaloid consisting preparations of the Phellodendron lavallei bark.
abstract: The aim of the research was to work out the technology and tablet composition from new galenic preparations consisting of alkaloids of the bark of Phellodendron lavallei and hydrochloride of berberin on the base of complex research. The bark of the Phellodendron lavallei introduced in Georgia contains alkaloids, from which 2% is berberine used for curing chronicle hepatitis, hepatic cholecystitis and bilestone disease. The structural-mechanical and technological character of tablets and their masses were defined by the known methodic. Friability was studied by defining the fluctuation and bending corner. Volume density was established by using vibration cylinder. Volume density of powders was studied by pyknometers. Porosity was calculated by the bearing of volume density of the masses. The size of pressing was established by defining the firmness of tablets. The granule composition was defined by analysis. On the basis of studying technological and physical-chemical character features of the substances of new galenic preparations and individual substances consisting of alkaloids got from the bark of Phellodendron lavallei, it is scientifically proved and practically offered optimal technological parameters of tablets forming process and recipes.
authors.affiliation: Tbilisi State Medical University, Tbilisi, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Meskheli
authors.forename: V
authors.initials: V
authors.lastname: Vachnadze
authors.lastname: Kurdiani
authors.forename: N
authors.initials: N
authors.lastname: Tsagareishvili
authors.forename: A
authors.initials: A
authors.lastname: Bakuridze
mesh_terms: D001600:Berberine Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D032102:Phellodendron / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D011786:Quality Control; D013607:Tablets
chemical_list: D001600:Berberine Alkaloids; D013607:Tablets