title: Nasopharyngeal carcinoma with pericardial metastasis.
abstract: Nasopharyngeal carcinoma (NPC) is prevalent in Taiwan and is characterized by a high frequency of nodal metastasis. The most common organs with distal metastases are the bones, lungs, and liver, with extremely rare cases to the pericardium. Herein, we report a rare case with NPC who presented with dyspnea and orthopnea. Serial studies, including pericardial biopsy, revealed NPC with pericardial metastasis and pericardial effusion. The tumor cells of both the original and metastatic tumors were positive for Epstein-Barr virus by in situ hybridization. This is the first histologically confirmed case of NPC with pericardial metastasis.
authors.affiliation: Division of Hemato-Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
authors.forename: Shang-Wen
authors.initials: SW
authors.lastname: Chen
authors.forename: Chao-Hsun
authors.initials: CH
authors.lastname: Chen
authors.forename: Chao-Jung
authors.initials: CJ
authors.lastname: Tsao
authors.forename: Wen-Tsung
authors.initials: WT
authors.lastname: Huang
authors.forename: Shih-Sung
authors.initials: SS
authors.lastname: Chuang
mesh_terms: D000328:Adult; D001706:Biopsy; D002277:Carcinoma; D004417:Dyspnea / Q000503:physiopathology; D020031:Epstein-Barr Virus Infections / Q000473:pathology* / Q000821:virology; D006338:Heart Neoplasms / Q000556:secondary* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000821:virology; D010490:Pericardial Effusion / Q000503:physiopathology; D010496:Pericardium / Q000473:pathology* / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D013624:Taiwan; D014057:Tomography, X-Ray Computed
chemical_list: D012367:RNA, Viral