title: A comparative evaluation of combination therapy of fluconazole 1% and urea 40% compared with fluconazole 1% alone in a nail lacquer for treatment of onychomycosis: therapeutic trial.
abstract: This is a randomized, double-blind study enrolling 70 patients with onychomycosis of the finger and toenails. Clinical and mycological efficacies as well as measures of safety were assessed monthly for a maximum of 6 months of treatment. The treatment regimens were: fluconazole 1% and fluconazole 1% with urea 40%. These results indicated topical treatment of onychomycosis with a combination of fluconazole 1% and urea 40% was more effective (82.8%) than fluconazole 1% (62.8%) nail lacquer alone in treatment of dermatophytic onychomycosis. Fluconazole was well tolerated and side effects were negligible. At the end of therapy and the end of the 6-month follow-up, fluconazole 1% and urea 40% demonstrated statistically significant superiority in clinical and mycological responses compared with fluconazole 1% alone.
authors.affiliation: Medical Mycology Department, Pasteur Institute of Iran. basiri@pasteur.ac.ir
authors.forename: Shahindokht
authors.initials: S
authors.lastname: Bassiri-Jahromi
authors.forename: Amir Houshang
authors.initials: AH
authors.lastname: Ehsani
authors.forename: Mostafa
authors.initials: M
authors.lastname: Mirshams-Shahshahani
authors.forename: Behrooz
authors.initials: B
authors.lastname: Jamshidi
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007764:Lacquer; D008297:Male; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy*; D014508:Urea / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D015725:Fluconazole; D014508:Urea