title: Click chemistry-based functionalization on non-oxidized silicon substrates.
abstract: Copper-catalyzed azide-alkyne cycloaddition (CuAAC), combined with the chemical stability of the Si-C-bound organic layer, serves as an efficient tool for the modification of silicon substrates, particularly for the immobilization of complex biomolecules. This review covers recent advances in the preparation of alkynyl- or azido-terminated "clickable" platforms on non-oxidized silicon and their further derivatization by means of the CuAAC reaction. The exploitation of these "click"-functionalized organic thin films as model surfaces to study many biological events was also addressed, as they are directly relevant to the on-going effort of creating silicon-based molecular electronics and chemical/biomolecular sensors.
authors.affiliation: Department of Chemistry & Center for Materials Chemistry, University of Houston, Houston, Texas 77204, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Cai
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D012825:Silicon / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D003300:Copper; D012825:Silicon