title: Long-term treatment of invasive sinus, tracheobroncheal, pulmonary and intracerebral aspergillosis in acute lymphoblastic leukaemia.
abstract: A 59-year-old male with acute lymphoblastic leukemia developed sinus, tracheobroncheal, pulmonary, and intracerebral aspergillosis. All lesions except the intracerebral aspergillosis healed after combination antifungal treatment. Long-term voriconazole--but not posaconazole--therapy induced partial regression of the cerebral manifestations. At the time of writing, 3.5 years after the initial diagnosis, the patient is working half-time and suffers from a possible voriconazole-induced polyneuropathy.
authors.affiliation: Division of Hematology, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden. magnus.bjorkholm@karolinska.se
authors.forename: M
authors.initials: M
authors.lastname: Björkholm
authors.forename: M
authors.initials: M
authors.lastname: Kalin
authors.forename: P
authors.initials: P
authors.lastname: Grane
authors.forename: F
authors.initials: F
authors.lastname: Celsing
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000302:isolation & purification; D001921:Brain / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D000077336:Caspofungin; D054022:Cerebrum / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D054714:Echinocandins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007830:Larynx / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D055666:Lipopeptides; D008168:Lung / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020953:Neuroaspergillosis / Q000188:drug therapy* / Q000382:microbiology*; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000382:microbiology / Q000503:physiopathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000382:microbiology; D055732:Pulmonary Aspergillosis / Q000188:drug therapy* / Q000382:microbiology*; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use; D013548:Sweden; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B; D000077336:Caspofungin; D065819:Voriconazole