title: Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication.
abstract: The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological processes like cell cycle regulation. We report that HPBP inhibits HIV-1 gene transcription and replication in T cell line, primary peripherical blood lymphocytes and primary macrophages. We show that HPBP is efficient in naïve and HIV-1 AZT-resistant strains. Our results revealed HPBP as a new and potent anti HIV molecule that inhibits transcription of the virus, which has not yet been targeted by HAART and therefore opens new strategies in the treatment of HIV infection.
authors.affiliation: Institut de Parasitologie et Pathologie Tropicale, EA 4438, Université de Strasbourg, 3 rue Koeberlé, 67000 Strasbourg, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Cherrier
authors.forename: Mikael
authors.initials: M
authors.lastname: Elias
authors.forename: Alicia
authors.initials: A
authors.lastname: Jeudy
authors.forename: Guillaume
authors.initials: G
authors.lastname: Gotthard
authors.forename: Valentin
authors.initials: V
authors.lastname: Le Douce
authors.forename: Houda
authors.initials: H
authors.lastname: Hallay
authors.forename: Patrick
authors.initials: P
authors.lastname: Masson
authors.forename: Andrea
authors.initials: A
authors.lastname: Janossy
authors.forename: Ermanno
authors.initials: E
authors.lastname: Candolfi
authors.forename: Olivier
authors.initials: O
authors.lastname: Rohr
authors.forename: Eric
authors.initials: E
authors.lastname: Chabrière
authors.forename: Christian
authors.initials: C
authors.lastname: Schwartz
mesh_terms: D002478:Cells, Cultured; D015497:HIV-1 / Q000276:immunology* / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000821:virology; D008264:Macrophages / Q000276:immunology / Q000821:virology; D028044:Phosphate-Binding Proteins / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D014158:Transcription, Genetic; D014779:Virus Replication
chemical_list: D028044:Phosphate-Binding Proteins