title: Synthesis, spectroscopic, crystal structure and DNA binding of Ru(II) complexes with 2-hydroxy-benzoic acid [1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-ethylidene]-hydrazide.
abstract: Reactions of 2-hydroxy-benzoic acid [1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-ethylidene]-hydrazide (H(2)L) with [RuHCl(CO)(EPh(3))(3)] (E = P or As) were carried out and the new complexes obtained were characterized by elemental analysis, electronic, IR, (1)H NMR and (13)C NMR spectroscopic techniques and single crystal X-ray diffraction studies. Complex (1) crystallizes in the monoclinic space group P2(1)/c with unit cell dimensions a=18.6236(17) Å, b=12.8627(12) Å, c=21.683(2) Å, α=90.00, β=114.626(2), γ=90.00 V=4721.8(8) Å, Z=4. The crystal structure of the complex shows Ru(II) atom is six-coordinated, forming a slightly distorted octahedral geometry with two P atoms in axial positions, and three chelating donor atoms of the tridentate Schiff base ligand and one carbonyl group located in the equatorial plane. The molecular structure is stabilized by intramolecular O-H···N interactions. No intermolecular hydrogen bond was observed. The intramolecular hydrogen bond exists between the oxygen atom from salicylic acid moiety and nitrogen from the same moiety. A variety of solution studies were carried out for the determination of DNA binding mode of the complexes. The results suggest that both complexes bind to Herring sperm DNA via non intercalative mode.
authors.affiliation: Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, 1370 Sankyuk-dong, Buk-gu, Deagu 702-701, Republic of Korea.
authors.forename: Nataraj
authors.initials: N
authors.lastname: Chitrapriya
authors.forename: Thangavel Sathiya
authors.initials: TS
authors.lastname: Kamatchi
authors.forename: Matthias
authors.initials: M
authors.lastname: Zeller
authors.forename: Hyosun
authors.initials: H
authors.lastname: Lee
authors.forename: Karuppannan
authors.initials: K
authors.lastname: Natarajan
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D005399:Fishes / Q000235:genetics; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry*; D008297:Male; D008954:Models, Biological; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D020156:Salicylic Acid / Q000737:chemistry; D013057:Spectrum Analysis; D013094:Spermatozoa / Q000378:metabolism
chemical_list: D006834:Hydrazines; D009942:Organometallic Compounds; D012428:Ruthenium; D004247:DNA; D020156:Salicylic Acid