title: High vancomycin MIC and complicated methicillin-susceptible Staphylococcus aureus bacteremia.
abstract: We conducted a retrospective study of 99 patients with methicillin-suseptible Staphylococcus aureus catheter-related bacteremia in which vancomycin MIC was determined by Etest. High vancomycin MIC (>1.5 ug/mL) was the only independent risk factor for development of complicated bacteremia caused by methicillin-susceptible S. aureus (odds ratio 22.9, 95% confidence interval 6.7-78.1).
authors.affiliation: University Hospital 12 de Octubre, Madrid, Spain. jaguadog@medynet.com
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Aguado
authors.forename: Rafael
authors.initials: R
authors.lastname: San-Juan
authors.forename: Antonio
authors.initials: A
authors.lastname: Lalueza
authors.forename: Francisca
authors.initials: F
authors.lastname: Sanz
authors.forename: Joaquin
authors.initials: J
authors.lastname: Rodríguez-Otero
authors.forename: Carmen
authors.initials: C
authors.lastname: Gómez-Gonzalez
authors.forename: Fernando
authors.initials: F
authors.lastname: Chaves
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D005260:Female; D006020:Glycopeptides / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology*; D047090:beta-Lactams / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D047090:beta-Lactams; D014640:Vancomycin; D008712:Methicillin