title: [Vascular depression in the elderly. Does inflammation play a role?].
abstract: Vascular depression in the elderly. Does inflammation play a role?Depression is the most common comorbidity in the elderly, and it is a major determinant of disability. The late-onset depression in highly associated to cardiovascular disease. Depressive symptoms may follow vascular brain damage, especially when mood regulating areas are affected. However depression is strongly associated to vascular disease even when there is no manifest brain damage. Recently great attention has been given to chronic inflammation, both related to depression and vascular disease. Both experimental and clinical evidence shows that a rise in the concentrations of proinflammatory cytokines and glucocorticoids in depressed patients is associated with defect in serotonergic function. Chronic inflammation may underlie many forms of depression associated with vascular disease and metabolic syndrome. The importance of the inflammation hypothesis of depression lies is that psychotropic drugs may have central anti-inflammatory action, and that new generation of central anti-inflammatory drugs may be useful in depression treatment.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Viscogliosi
authors.forename: Paola
authors.initials: P
authors.lastname: Andreozzi
authors.forename: Iulia Maria
authors.initials: IM
authors.lastname: Chiriac
authors.forename: Evaristo
authors.initials: E
authors.lastname: Ettorre
authors.forename: Achiropita
authors.initials: A
authors.lastname: Vulcano
authors.forename: Adriana
authors.initials: A
authors.lastname: Servello
authors.forename: Benedetta
authors.initials: B
authors.lastname: Marigliano
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Marigliano
mesh_terms: D000368:Aged; D000375:Aging; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000150:complications / Q000503:physiopathology; D015992:Body Mass Index; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D004359:Drug Therapy, Combination; D019317:Evidence-Based Medicine; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D024821:Metabolic Syndrome / Q000150:complications / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D005938:Glucocorticoids; D011619:Psychotropic Drugs