title: Evolutionary rewiring and reprogramming of bacterial transcription regulation.
abstract: Rewiring and reprogramming of transcriptional regulation took place during bacterial speciation. The mechanistic alterations among transcription factors, cis-regulatory elements and target genes confer bacteria novel ability to adapt to stochastic environmental changes. This process is critical to their survival, especially for bacterial pathogens subjected to accelerated evolution. In the past two decades, the investigators not only completed the sequences of numerous bacterial genomes, but also made great progress in understanding the molecular basis of evolution. Here we briefly reviewed the current knowledge on the mechanistic changes among orthologous, paralogous and xenogenic regulatory circuits, which were caused by genetic recombinations such as gene duplication, horizontal gene transfer, transposable elements and different genetic contexts. We also discussed the potential impact of this area on theoretical and applied studies of microbes.
authors.affiliation: State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Qian
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics; D001419:Bacteria / Q000235:genetics*; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D020440:Gene Duplication; D015964:Gene Expression Regulation, Bacterial; D022761:Gene Transfer, Horizontal; D049810:Genetic Speciation; D016680:Genome, Bacterial; D011995:Recombination, Genetic; D014158:Transcription, Genetic
chemical_list: D004251:DNA Transposable Elements