title: Phenylpropanoid and phenylisoprenoid metabolites from Asteraceae species as inhibitors of protein carbonylation.
abstract: Three phenolic antioxidant and anti-inflammatory compounds: 7-methylaromadendrin, isoprenylhydroquinone glucoside, and 3.5-dicaffeoylquinic acid methyl ester, all isolated from Western Mediterranean Asteraceae species, have been studied for their inhibitory activity against protein carbonylation, a harmful post-translational modification of peptide chains associated with degenerative diseases. All compounds have proven to be effective, with 50% inhibitory concentration (IC₅₀) values in the micromolar range, against bovine serum albumin carbonylation caused by hypochlorite, peroxynitrite, and phorbol ester-induced leukocyte oxidative burst.
authors.affiliation: Departament de Farmacologia, Universitat de València, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Marín
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Giner
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Recio
authors.forename: Salvador
authors.initials: S
authors.lastname: Máñez
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002474:Cell-Free System; D002726:Chlorogenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D044950:Flavanones / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D005960:Glucosides / Q000494:pharmacology*; D006801:Humans; D006873:Hydroquinones / Q000494:pharmacology*; D006997:Hypochlorous Acid / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009504:Neutrophils / Q000378:metabolism; D030421:Peroxynitrous Acid / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology*; D010703:Phorbol Esters / Q000494:pharmacology; D050050:Protein Carbonylation / Q000187:drug effects*; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D016897:Respiratory Burst; D012710:Serum Albumin, Bovine / Q000378:metabolism
chemical_list: C525762:3,5-dicaffeoylquinic acid methyl ester; C582836:7-methylaromadendrin; D000975:Antioxidants; D044950:Flavanones; D005419:Flavonoids; D005960:Glucosides; D006873:Hydroquinones; D010636:Phenols; D010703:Phorbol Esters; C501647:isoprenylhydroquinone glucoside; D030421:Peroxynitrous Acid; D012710:Serum Albumin, Bovine; D002726:Chlorogenic Acid; D006997:Hypochlorous Acid; C080220:aromadedrin