title: The role of serum myeloid-related protein 8/14 complex in Henoch-Schönlein purpura nephritis.
abstract: Myeloid-related protein (MRP) 8/14 complex is a marker of monocyte and neutrophil activation. We evaluated whether serum MRP8/14 complex is associated with clinical manifestations and pathological findings of Henoch-Schönlein purpura nephritis (HSPN). Patients were divided into two groups based on serum MRP8/14 complex levels at renal biopsy. Group 1 consisted of 18 HSPN patients with less than median (670 ng/ml) MRP8/14 complex levels, and Group 2 of 12 HSPN patients with greater than median levels. Clinical manifestations, laboratory findings and serum E-selectin levels, as a marker of vascular endothelial cell dysfunction, as well as histological and immunohistochemical findings were investigated for both groups. We also measured MRP8/14 complex levels in disease control and healthy control children. Urinary protein excretions, serum MRP8/14 complex levels, and serum E-selectin levels were all higher in Group 2 than in Group 1 patients. Serum MRP8/14 complex levels were higher in HSPN patients than in controls. Serum MRP8/14 complex levels were strongly associated with serum E-selectin levels. Pathological findings revealed that the proportions of patients with ISKDC grades III, IV and V in Group 2 were higher than in Group 1. Our findings suggest that serum MRP8/14 complex levels might be associated with the severity of renal injury and endothelial cell dysfunction in HSPN patients.
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima 960-1295, Japan. kyuki@fmu.ac.jp
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Shinichirou
authors.initials: S
authors.lastname: Ohara
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Abe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Suyama
authors.forename: Masatoki
authors.initials: M
authors.lastname: Sato
authors.forename: Koichi
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Hosoya
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D040501:Calgranulin A / Q000097:blood*; D040502:Calgranulin B / Q000097:blood*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D019040:E-Selectin / Q000097:blood; D004730:Endothelium, Vascular / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D007150:Immunohistochemistry; D007564:Japan; D007668:Kidney / Q000276:immunology / Q000473:pathology; D039841:Leukocyte L1 Antigen Complex / Q000097:blood*; D008297:Male; D009393:Nephritis / Q000276:immunology* / Q000473:pathology; D012720:Severity of Illness Index; D015854:Up-Regulation; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D040501:Calgranulin A; D040502:Calgranulin B; D019040:E-Selectin; D039841:Leukocyte L1 Antigen Complex; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C546936:SELE protein, human