title: Acetyl- and butyryl-cholinesterase inhibitory activities of mansorins and mansonones.
abstract: Cholinesterase (ChE) inhibitory activities of three coumarins (mansorins A-C) and five naphthoquinones (mansonone C, E, G and H) were evaluated to determine the relationships between the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory effects and the core structures of these compounds. Among the tested compounds, mansonone E exhibited the highest ChE inhibitory activities, with IC₅₀ values in the low micromolar levels. In addition to revealing the ChE inhibitory activities of naphthoquinones for the first time, the results also revealed structure-activity relationship information that could be useful for further modification. Furthermore, the study also supports the hypothesis that mansonones are the active component in Thespesia populnea, a plant that previously has been shown to enhance memory activity in an in vivo study.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok 10330, Thailand.
authors.forename: Nisa
authors.initials: N
authors.lastname: Changwong
authors.forename: Chalisa
authors.initials: C
authors.lastname: Sabphon
authors.forename: Kornkanok
authors.initials: K
authors.lastname: Ingkaninan
authors.forename: Pattara
authors.initials: P
authors.lastname: Sawasdee
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry*; D002091:Butyrylcholinesterase / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry; D004789:Enzyme Activation; D057075:Enzyme Assays; D005663:Furans / Q000737:chemistry; D020128:Inhibitory Concentration 50; D019660:Malvaceae / Q000737:chemistry*; D009285:Naphthoquinones / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D003374:Coumarins; D005663:Furans; D009285:Naphthoquinones; D012717:Sesquiterpenes; C480061:dehydrooxoperezinone; C517072:mansonone C; C496164:mansonone E; C121002:mansonone H; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase