title: Synthesis and antimicrobial studies of chalconyl pregnenolones.
abstract: An efficient and facile synthesis of 17-chalconyl derivatives of pregnenolone and their evaluation as antimicrobial agents against various microbial strains is reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding chalcone derivatives. The compounds 3a-3j showed significant antimicrobial activity against all microbial strains used for testing.
authors.affiliation: Department of Chemistry, Islamia College of Science and Commerce, Srinagar, 190009 J&K, India. abidrrl@gmail.com
authors.forename: Abid H
authors.initials: AH
authors.lastname: Banday
authors.forename: M
authors.initials: M
authors.lastname: Iqbal Zargar
authors.forename: Bashir A
authors.initials: BA
authors.lastname: Ganaie
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006801:Humans; D011284:Pregnenolone / Q000031:analogs & derivatives*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D047188:Chalcones; D011284:Pregnenolone