title: HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization.
abstract: A vast majority of the burden from neglected tropical diseases result from helminth infections (nematodes and platyhelminthes). Parasitic helminthes infect over 2 billion, exerting a high collective burden that rivals high-mortality conditions such as AIDS or malaria, and cause devastation to crops and livestock. The challenges to improve control of parasitic helminth infections are multi-fold and no single category of approaches will meet them all. New information such as helminth genomics, functional genomics and proteomics coupled with innovative bioinformatic approaches provide fundamental molecular information about these parasites, accelerating both basic research as well as development of effective diagnostics, vaccines and new drugs. To facilitate such studies we have developed an online resource, HelmCoP (Helminth Control and Prevention), built by integrating functional, structural and comparative genomic data from plant, animal and human helminthes, to enable researchers to develop strategies for drug, vaccine and pesticide prioritization, while also providing a useful comparative genomics platform. HelmCoP encompasses genomic data from several hosts, including model organisms, along with a comprehensive suite of structural and functional annotations, to assist in comparative analyses and to study host-parasite interactions. The HelmCoP interface, with a sophisticated query engine as a backbone, allows users to search for multi-factorial combinations of properties and serves readily accessible information that will assist in the identification of various genes of interest. HelmCoP is publicly available at: http://www.nematode.net/helmcop.html.
authors.affiliation: The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America.
authors.forename: Sahar
authors.initials: S
authors.lastname: Abubucker
authors.forename: John
authors.initials: J
authors.lastname: Martin
authors.forename: Christina M
authors.initials: CM
authors.lastname: Taylor
authors.forename: Makedonka
authors.initials: M
authors.lastname: Mitreva
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D023281:Genomics; D006373:Helminthiasis / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D006376:Helminths / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D008969:Molecular Sequence Data; D012984:Software; D013045:Species Specificity; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry; D014584:User-Computer Interface; D014612:Vaccines
chemical_list: D000871:Anthelmintics; D014612:Vaccines; D013762:Tetrahydrofolate Dehydrogenase