title: 4D flow CMR in assessment of valve-related ascending aortic disease.
abstract: Blood flow imaging with 3-dimensional time-resolved, phase-contrast cardiac magnetic resonance (4-dimensional [4D] Flow) is an innovative and visually appealing method for studying cardiovascular disease that allows quantification of important secondary vascular parameters including wall shear stress. The hypothesis of this pilot study is that 4D Flow will become a powerful tool for characterizing the relationship of aortic valve-related flow dynamics, especially with bicuspid aortic valve (BAV), and progression of ascending aortic (AsAo) dilation. We identified 46 patients previously studied with 4D Flow: tricuspid aortic valve patients without valvular disease (n = 20), and BAV patients with either normal flow (n = 7) or eccentric systolic jets resulting in abnormal right-handed helical AsAo flow (n = 19). The subgroup of patients with BAV and eccentric systolic AsAo blood flow was found to have significantly and asymmetrically elevated wall shear stress. This increased hemodynamic burden may place them at risk for AsAo aneurysm.
authors.affiliation: Department of Radiology, University of California-San Francisco, San Francisco, California 94143-0628, USA. michael.hope@ucsf.edu
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hope
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Hope
authors.forename: Stephen E S
authors.initials: SE
authors.lastname: Crook
authors.forename: Karen G
authors.initials: KG
authors.lastname: Ordovas
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Urbania
authors.forename: Marc T
authors.initials: MT
authors.lastname: Alley
authors.forename: Charles B
authors.initials: CB
authors.lastname: Higgins
mesh_terms: D000293:Adolescent; D000328:Adult; D001013:Aorta, Thoracic / Q000503:physiopathology*; D001014:Aortic Aneurysm / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D001021:Aortic Valve / Q000002:abnormalities* / Q000503:physiopathology; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010865:Pilot Projects; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult