title: Ovarian immature teratoma: treatment and outcome in a single institutional cohort.
abstract: OBJECTIVE
  The aim of this study was to evaluate clinicopathologic characteristics, treatment outcome and reproductive function in women diagnosed with ovarian immature teratoma.
  
  
  METHODS
  Thirty-four women with ovarian immature teratoma stages IA to IIIA were identified and included in this study. Patients were treated at one institution; Princess Margaret Hospital, Toronto, Canada between 1970 and 2005.
  
  
  RESULTS
  The median age at diagnosis was 25.0 years (range: 9.8-60.2 years). Twenty seven (79%) presented with stage IA disease, 5 (15%) with stage IC, 1 (3%) with stage 2B, and 1 (3%) with stage IIIA disease. Thirteen (38%) of the tumors were found to be grade 1, 12 (35%) grade 2, and 9 (27%) grade 3. Initial management was surgical for all patients: 22 (65%) unilateral oophorectomy, 7 (20%) cystectomy only, and 5 (15%) bilateral oophorectomy (4 with hysterectomy). Fourteen (41.8%) patients received adjuvant therapy. The median follow up was 4.8 years (range 0.2-24.3 years). Four patients recurred (histological grade 2 or 3) within 22 months (87.1% 2-year progression free survival). Only one clinical stage I patient who received adjuvant chemotherapy developed a recurrence. Three of the patients who recurred died from their disease. Eleven patients reported an attempt to conceive resulting in 11 pregnancies in 6 women (3 post chemotherapy).
  
  
  CONCLUSIONS
  The majority of patients diagnosed with an immature teratoma are cured of their disease. However, grade 2 or 3 tumors are associated with a greater chance of recurrence that can be fatal, predominantly within 2 years of diagnosis.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada. Danielle.Vicus@uhn.on.ca
authors.forename: Danielle
authors.initials: D
authors.lastname: Vicus
authors.forename: Mario E
authors.initials: ME
authors.lastname: Beiner
authors.forename: Blaise
authors.initials: B
authors.lastname: Clarke
authors.forename: Shany
authors.initials: S
authors.lastname: Klachook
authors.forename: Lisa W
authors.initials: LW
authors.lastname: Le
authors.forename: Stephane
authors.initials: S
authors.lastname: Laframboise
authors.forename: Helen
authors.initials: H
authors.lastname: Mackay
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D005260:Female; D005298:Fertility; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D011247:Pregnancy; D012189:Retrospective Studies; D013724:Teratoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult