title: Bio-based production of the platform chemical 1,5-diaminopentane.
abstract: In the rising era of bio-economy, the five carbon compound 1,5-diaminopentane receives increasing interest as platform chemical, especially as innovative building block for bio-based polymers. The vital interest in bio-based supply of 1,5-diaminopentane has strongly stimulated research on the development of engineered producer strains. Based on the state-of-art knowledge on the pathways and reactions linked to microbial 1,5-diaminopentane metabolism, the review covers novel systems metabolic engineering approaches towards hyper-producing cell factories of Corynebacterium glutamicum or Escherichia coli. This is integrated into the whole value chain from renewable feedstocks via 1,5-diaminopentane to innovative biopolymers involving bioprocess engineering considerations for economic supply.
authors.affiliation: Institute of Biochemical Engineering, Technische Universität Braunschweig, Gaussstrasse 17, 38106 Braunschweig, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Kind
authors.forename: Christoph
authors.initials: C
authors.lastname: Wittmann
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D053898:Biosynthetic Pathways; D002103:Cadaverine / Q000096:biosynthesis*; D048230:Corynebacterium glutamicum / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D007218:Industrial Microbiology
chemical_list: D001426:Bacterial Proteins; D002103:Cadaverine