title: Kinetic and thermodynamic control of G-quadruplex folding.
abstract: A matter of speed: when allowed to fold in a K(+)/poly(ethylene glycol) solution, the guanine (G)-rich strand of vertebrate telomere DNA forms a parallel/antiparallel G-quadruplex, which is a (3+1) hybrid, within microseconds before slowly transforming into the parallel one within hours. Thus, the conformation that a G-quadruplex initially adopts under physiological conditions may not be the one it adopts at the equilibrium state.
authors.affiliation: State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xue
authors.forename: Jia-quan
authors.initials: JQ
authors.lastname: Liu
authors.forename: Ke-wei
authors.initials: KW
authors.lastname: Zheng
authors.forename: Zhong-yuan
authors.initials: ZY
authors.lastname: Kan
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Hao
authors.forename: Zheng
authors.initials: Z
authors.lastname: Tan
mesh_terms: D000818:Animals; D002942:Circular Dichroism; D054856:G-Quadruplexes; D006801:Humans; D007477:Ions / Q000737:chemistry; D007700:Kinetics; D009690:Nucleic Acid Conformation; D011092:Polyethylene Glycols / Q000737:chemistry; D011188:Potassium / Q000737:chemistry; D016615:Telomere / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D007477:Ions; D011092:Polyethylene Glycols; D011188:Potassium