title: A review on steroidal 5α-reductase inhibitors for treatment of benign prostatic hyperplasia.
abstract: Benign prostatic hyperplasia (BPH) is a kind of common noncancerous prostate gland enlargement with growing tendency in recent years. 5α-reductase is the key enzyme responsible for dihydrotestosterone biosynthesis and has been considered as an important target for designing inhibitors as potent therapeutic agents for BPH. Finasteride, the first steroidal 5α-reductase inhibitor, has been marketed worldwide as a drug for BPH. During these years, many other novel types of 5α-reductase inhibitors are being studied. This review summarizes recent advancement in steroidal 5α-reductase inhibitors.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang Road, Nanjing 210009, Jiangsu, P.R. China.
authors.forename: J
authors.initials: J
authors.lastname: Sun
authors.forename: H
authors.initials: H
authors.lastname: Xiang
authors.forename: L-L
authors.initials: LL
authors.lastname: Yang
authors.forename: J-B
authors.initials: JB
authors.lastname: Chen
mesh_terms: D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000737:chemistry* / Q000378:metabolism; D058891:5-alpha Reductase Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D001378:Azasteroids / Q000737:chemistry / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011278:Pregnanes / Q000737:chemistry / Q000627:therapeutic use; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000201:enzymology
chemical_list: D058891:5-alpha Reductase Inhibitors; D001378:Azasteroids; D001688:Biological Products; D011278:Pregnanes; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase