title: Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity.
abstract: A little over 1 year ago, we lost a bright scientist and a dear colleague who, in his younger years, proposed the 'heretical' idea that lysosomes could selectively degrade cytosolic proteins. That scientist was J. Fred Dice, and his lifetime's discovery was the degradative pathway that we now know as chaperone-mediated autophagy.
authors.affiliation: Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York 10461, USA. ana-maria.cuervo@einstein.yu.edu
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Cuervo
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D001900:Boston; D002140:California; D049673:History, 20th Century; D008247:Lysosomes / Q000502:physiology*; D008954:Models, Biological; D018832:Molecular Chaperones / Q000266:history* / Q000502:physiology; D051381:Rats; D012106:Research / Q000266:history; D013030:Spain
chemical_list: D018832:Molecular Chaperones