title: Genomic regions associated with ventro-cranial chronic pleuritis in pig.
abstract: Ventro-cranial chronic pleuritis can be a result of pleuropneumonia and enzootic pneumonia. These diseases cause severe losses in intensive pig production worldwide, but host resistance is difficult to breed for. It could be beneficial to use marker-assisted selection, and a step towards this is to identify genomic regions associated with the trait. For this purpose, 7304 pigs from 11 boar families were analysed for associations between single nucleotide polymorphisms and ventro-cranial chronic pleuritis. The pigs were genotyped by the use of the iSelect Custom 7 K porcine SNP Chip. Quantitative trait loci (QTL), significant at the chromosome-wide level, were identified on Sus scrofa chromosomes (SSC) 2, 4, 11, 12 and 13 in four different boar families. The QTL on SSC 4 in family G was also significant at the genome-wide threshold according to Bonferroni correction. We have identified a number of candidate genes, but the causative mutations still need to be identified. Markers closely associated with the resistance traits have a strong potential for use in breeding towards animals with improved characteristics concerning ventro-cranial chronic pleuritis.
authors.affiliation: Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Aarhus University, Tjele, Denmark.
authors.forename: K K
authors.initials: KK
authors.lastname: Sørensen
authors.forename: V R
authors.initials: VR
authors.lastname: Gregersen
authors.forename: O F
authors.initials: OF
authors.lastname: Christensen
authors.forename: I H
authors.initials: IH
authors.lastname: Velander
authors.forename: C
authors.initials: C
authors.lastname: Bendixen
mesh_terms: D000818:Animals; D033481:Chromosomes, Mammalian / Q000235:genetics; D002908:Chronic Disease; D005819:Genetic Markers; D055106:Genome-Wide Association Study; D010998:Pleurisy / Q000235:genetics / Q000662:veterinary*; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci / Q000235:genetics; D012641:Selection, Genetic; D034421:Sus scrofa / Q000235:genetics*
chemical_list: D005819:Genetic Markers