title: Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats.
abstract: We observed that in isolated perfused rat kidneys, sphingosine-1-phosphate produces S1P(2) receptor-mediated vasoconstriction, and this response increased in kidneys of diabetic rats. These results suggest that the antagonists of S1P(2) receptor may have potential as drugs to control diabetes-induced vascular complications.
authors.affiliation: Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, México City, Mexico. rociobtst@yahoo.com
authors.forename: Rocio
authors.initials: R
authors.lastname: Bautista-Pérez
authors.forename: Abraham
authors.initials: A
authors.lastname: Arellano
authors.forename: Martha
authors.initials: M
authors.lastname: Franco
authors.forename: Horacio
authors.initials: H
authors.lastname: Osorio
authors.forename: Israel
authors.initials: I
authors.lastname: Coronel
mesh_terms: D000818:Animals; D015153:Blotting, Western; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism*; D066298:In Vitro Techniques; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism*; D008246:Lysophospholipids / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D049349:Receptors, Lysosphingolipid / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine