title: Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients.
abstract: BACKGROUND
  Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of ACP1 polymorphisms to susceptibility to rheumatoid arthritis (RA), as well as the potential contribution of these polymorphisms to the increased risk of cardiovascular disease (CV) observed in RA patients.
  
  
  METHODS
  A set of 1,603 Spanish RA patients and 1,877 healthy controls were included in the study. Information related to the presence/absence of CV events was obtained from 1,284 of these participants. All individuals were genotyped for four ACP1 single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247, and rs3828329, using a predesigned TaqMan SNP genotyping assay. Classical ACP1 alleles (*A, *B and *C) were imputed with SNP data.
  
  
  RESULTS
  No association between ACP1 gene polymorphisms and susceptibility to RA was observed. However, when RA patients were stratified according to the presence or absence of CV events, an association between rs11553742*T and CV events was found (P = 0.012, odds ratio (OR) = 2.62 (1.24 to 5.53)). Likewise, the ACP1*C allele showed evidence of association with CV events in patients with RA (P = 0.024, OR = 2.43).
  
  
  CONCLUSIONS
  Our data show that the ACP1*C allele influences the risk of CV events in patients with RA.
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Avd, del Conocimiento s/n, 18010, Granada, Spain. mteruel@ipb.csic.es
authors.forename: María
authors.initials: M
authors.lastname: Teruel
authors.forename: Jose-Ezequiel
authors.initials: JE
authors.lastname: Martin
authors.forename: Carlos
authors.initials: C
authors.lastname: González-Juanatey
authors.forename: Raquel
authors.initials: R
authors.lastname: López-Mejias
authors.forename: Jose A
authors.initials: JA
authors.lastname: Miranda-Filloy
authors.forename: Ricardo
authors.initials: R
authors.lastname: Blanco
authors.forename: Alejandro
authors.initials: A
authors.lastname: Balsa
authors.forename: Dora
authors.initials: D
authors.lastname: Pascual-Salcedo
authors.forename: Luis
authors.initials: L
authors.lastname: Rodriguez-Rodriguez
authors.forename: Benjamin
authors.initials: B
authors.lastname: Fernández-Gutierrez
authors.forename: Ana M
authors.initials: AM
authors.lastname: Ortiz
authors.forename: Isidoro
authors.initials: I
authors.lastname: González-Alvaro
authors.forename: Carmen
authors.initials: C
authors.lastname: Gómez-Vaquero
authors.forename: Nunzio
authors.initials: N
authors.lastname: Bottini
authors.forename: Javier
authors.initials: J
authors.lastname: Llorca
authors.forename: Miguel A
authors.initials: MA
authors.lastname: González-Gay
authors.forename: Javier
authors.initials: J
authors.lastname: Martin
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000150:complications* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors
chemical_list: D011518:Proto-Oncogene Proteins; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases