title: The association between height and prostate cancer grade in the Early Stage Prostate Cancer Cohort Study.
abstract: OBJECTIVE
  We examined the relationship between height and prostate cancer grade.
  
  
  METHODS
  The Early Stage Prostate Cancer Cohort Study is an observational cohort of 1,037 men diagnosed with early-stage prostate cancer, T(0-3)N(x)M(0). High-grade prostate cancer was defined as a biopsy Gleason score ≥ 7 (4 + 3). Logistic regression models were created to calculate odds ratios (OR) and 95% confidence intervals (CI) for the cross-sectional relationship between height and prostate cancer grade in the overall cohort and subpopulations.
  
  
  RESULTS
  We identified 939 participants with a biopsy Gleason score. High-grade prostate cancer was diagnosed in 138 participants. Overall, participants in the highest quartile of height were more than twice as likely to have a Gleason score ≥ 7 (4 + 3) than participants in the lowest quartile of height, OR 2.14 (95% CI 1.11, 4.14), after multivariate adjustment. Participants in the highest quartile of height were more likely to be diagnosed with high-grade prostate cancer than participants in the lowest quartile of height among participants who were black, OR 8.00 (95% CI 1.99, 32.18), and participants who had diabetes mellitus, OR 5.09 (95% CI 1.30, 19.98).
  
  
  CONCLUSIONS
  Height is associated with increased risk of high-grade prostate cancer overall and perhaps among certain subpopulations.
authors.affiliation: Massachusetts Veterans Epidemiology and Research Information Center, Veterans Affairs Medical Center, Boston, MA 02130, USA. wfarwell@gmail.com
authors.forename: Wildon R
authors.initials: WR
authors.lastname: Farwell
authors.forename: Christopher
authors.initials: C
authors.lastname: Lourenco
authors.forename: Erika
authors.initials: E
authors.lastname: Holmberg
authors.forename: Robert B
authors.initials: RB
authors.lastname: Hall
authors.forename: Leonard
authors.initials: L
authors.lastname: D'Avolio
authors.forename: Elizabeth V
authors.initials: EV
authors.lastname: Lawler
authors.forename: J
authors.initials: J
authors.lastname: Michael Gaziano
mesh_terms: D000368:Aged; D044383:Black People; D001827:Body Height; D015331:Cohort Studies; D016001:Confidence Intervals; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000473:pathology*