title: Selecting appropriate voxel-based methods for neuroimaging studies.
abstract: We highlight a fundamental difference between voxel-based methods that interrogate signal intensity directly and those that interrogate morphometric features; we discuss how signal intensity changes might erroneously affect morphometric measures, and we provide some guidance for selection of appropriate methods to address particular hyphotheses. Our discussion is motivated by a recent application of voxel-based morphometry methods to T2-weighted images (T2-Voxel Based Morphometry; T2-VBM). In this context we discuss alternative approaches including Voxel-Based T2-Relaxometry (VBR) and Voxel Based Iterative Sensitivity analysis of T2-Weighted Images (VBIS-T2).
authors.affiliation: Florey Neuroscience Institutes, Melbourne Brain Centre, Austin Hospital, Victoria, Australia. BRI@brain.org.au
authors.forename: David F
authors.initials: DF
authors.lastname: Abbott
authors.forename: Gaby S
authors.initials: GS
authors.lastname: Pell
authors.forename: Heath R
authors.initials: HR
authors.lastname: Pardoe
authors.forename: Graeme D
authors.initials: GD
authors.lastname: Jackson
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male