title: Preparation of a Series of 5-Methyl-3-(substituted)-[1,2,4]triazines.
abstract: Procedures for the synthesis of thirty-six 5-methyl-3-(substituted)-[1,2,4]triazines have been described. These compounds were evaluated for antagonism at metabotropic glutamate receptor subtype 5. Two compounds, 5b and 3c, were determined to be low micromolar inhibitors of mGluR5.
authors.affiliation: Center for Organic and Medicinal Chemistry, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709.
authors.forename: Moses G
authors.initials: MG
authors.lastname: Gichinga
authors.forename: Jeremy P
authors.initials: JP
authors.lastname: Olson
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Butala
authors.forename: Brian P
authors.initials: BP
authors.lastname: Gilmour
authors.forename: Hernán H
authors.initials: HH
authors.lastname: Navarro
authors.forename: F Ivy
authors.initials: FI
authors.lastname: Carroll