title: The role of CD40/CD40L and interferon regulatory factor 4 in Hodgkin lymphoma microenvironment.
abstract: Inflammation and cancer are two independent biological events that can play an interdependent role. The model of such interaction is represented by Hodgkin lymphoma (HL), where the microenvironment is dominated by an extensive mixed, potentially cellular inflammatory infiltrate that plays a decisive role in the pathobiology of HL. In this review we summarize updated information on the complex interactions between Hodgkin Reed-Sternberg (HRS) cells and their tissue microenvironment, highlighting the functional role of CD40/CD40L and interferon regulatory factor 4 (IRF4).
authors.affiliation: Experimental Oncology, Centro di Riferimento Oncologico, IRCCS-National Cancer Institute, Aviano, PN, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Aldinucci
authors.forename: Annunziata
authors.initials: A
authors.lastname: Gloghini
authors.forename: Antonio
authors.initials: A
authors.lastname: Pinto
authors.forename: Alfonso
authors.initials: A
authors.lastname: Colombatti
authors.forename: Antonino
authors.initials: A
authors.lastname: Carbone
mesh_terms: D019013:CD40 Antigens / Q000276:immunology*; D023201:CD40 Ligand / Q000276:immunology*; D006689:Hodgkin Disease / Q000503:physiopathology*; D006801:Humans; D050835:Interferon Regulatory Factors / Q000276:immunology*; D059016:Tumor Microenvironment; D000099218:Interferon Regulatory Factor-4
chemical_list: D019013:CD40 Antigens; D023201:CD40 Ligand; D050835:Interferon Regulatory Factors; D000099218:Interferon Regulatory Factor-4