title: Recombination rates in admixed individuals identified by ancestry-based inference.
abstract: Studies of recombination and how it varies depend crucially on accurate recombination maps. We propose a new approach for constructing high-resolution maps of relative recombination rates based on the observation of ancestry switch points among admixed individuals. We show the utility of this approach using simulations and by applying it to SNP genotype data from a sample of 2,565 African Americans and 299 African Caribbeans and detecting several hundred thousand recombination events. Comparison of the inferred map with high-resolution maps from non-admixed populations provides evidence of fine-scale differentiation in recombination rates between populations. Overall, the admixed map is well predicted by the average proportion of admixture and the recombination rate estimates from the source populations. The exceptions to this are in areas surrounding known large chromosomal structural variants, specifically inversions. These results suggest that outside of structurally variable regions, admixture does not substantially disrupt the factors controlling recombination rates in humans.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wegmann
authors.forename: Darren E
authors.initials: DE
authors.lastname: Kessner
authors.forename: Krishna R
authors.initials: KR
authors.lastname: Veeramah
authors.forename: Rasika A
authors.initials: RA
authors.lastname: Mathias
authors.forename: Dan L
authors.initials: DL
authors.lastname: Nicolae
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Yanek
authors.forename: Yan V
authors.initials: YV
authors.lastname: Sun
authors.forename: Dara G
authors.initials: DG
authors.lastname: Torgerson
authors.forename: Nicholas
authors.initials: N
authors.lastname: Rafaels
authors.forename: Thomas
authors.initials: T
authors.lastname: Mosley
authors.forename: Lewis C
authors.initials: LC
authors.lastname: Becker
authors.forename: Ingo
authors.initials: I
authors.lastname: Ruczinski
authors.forename: Terri H
authors.initials: TH
authors.lastname: Beaty
authors.forename: Sharon L R
authors.initials: SL
authors.lastname: Kardia
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Meyers
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Barnes
authors.forename: Diane M
authors.initials: DM
authors.lastname: Becker
authors.forename: Nelson B
authors.initials: NB
authors.lastname: Freimer
authors.forename: John
authors.initials: J
authors.lastname: Novembre
mesh_terms: D001741:Black or African American / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods*; D006239:Haplotypes; D006801:Humans; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic