title: [Study on the change of urinary iodine of different salt concentrations among the target population in an intervention trial].
abstract: OBJECTIVE
  To analyze the change of urinary iodine in a cohort of intervention trial and to observe the role of different doses on salt iodization and related impact factors on nutritional condition of iodine.
  
  
  METHODS
  Multistage cluster sampling was used to sample three townships in two counties for community intervention with different doses (15 ± 5, 25 ± 5, 35 ± 5) mg/kg.
  
  
  RESULTS
  Compared to the (35 ± 5) mg/kg group, the urine iodine levels of three experimental townships were gradually declining in county B when time went on, and the (15 ± 5) mg/kg group showed an obvious results, at 6, 12, 18 and 24 months, with the urine iodine level as 180.00, 186.10, 150.04, 191.28 µg/L respectively, which were in accordance with the WHO standard and reached to appropriate range (187.96 µg/L) at the 18 month. The townships at county Y under intervention had declined slightly, but the urine iodine levels did not reach the WHO standard. The thyroid volume declined from 3.65 ml to 3.40 ml in two counties and the difference between them was statistically significant.
  
  
  CONCLUSIONS
  To some extent, reducing the iodine concentration in salt, had a role of lowering the urine iodine level and reducing the strumous rate.
authors.affiliation: Department of Epidemiology, School of Public Health, Chongqing Medical University, Chongqing, China.
authors.forename: Yin-yin
authors.initials: YY
authors.lastname: Song
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Mu
authors.forename: Ge
authors.initials: G
authors.lastname: Li
authors.forename: Gui-wang
authors.initials: GW
authors.lastname: Dou
authors.forename: Xin-shu
authors.initials: XS
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Bai-sheng
authors.initials: BS
authors.lastname: Qian
authors.forename: Jian-lan
authors.initials: JL
authors.lastname: Chen
authors.forename: Mei
authors.initials: M
authors.lastname: Luo
mesh_terms: D002648:Child; D002681:China; D005260:Female; D006042:Goiter / Q000517:prevention & control; D006301:Health Services Needs and Demand; D006801:Humans; D007455:Iodine / Q000008:administration & dosage / Q000652:urine*; D008297:Male; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
chemical_list: D017673:Sodium Chloride, Dietary; C034024:iodized salt; D007455:Iodine