title: Memantine and catatonia: a case report and literature review.
abstract: Catatonia is a movement disorder with various possible etiologies. The majority of cases are associated with an underlying mood or psychotic disorder, while others are caused by medical conditions. Currently, benzodiazepines are the first-line psychopharmacologic agents in the treatment of catatonia. However, several cases have been reported in which treatment with memantine proved to be effective. We present the case of a 92-year-old female with major depressive disorder and associated catatonic symptoms. In this case, the patient's symptoms remitted quickly after the initiation of memantine. We review the possible causes of catatonia and pharmacologic treatments for the condition and highlight the possible benefits of N-methylD-aspartic acid receptor antagonists such as memantine in the treatment of catatonia.
authors.affiliation: University of South Florida Depart ment of Psychiatry and Neurosciences, Tampa, FL, USA.
authors.forename: Demian F
authors.initials: DF
authors.lastname: Obregon
authors.forename: Regina M
authors.initials: RM
authors.lastname: Velasco
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Wuerz
authors.forename: Maria C
authors.initials: MC
authors.lastname: Catalano
authors.forename: Glenn
authors.initials: G
authors.lastname: Catalano
authors.forename: David
authors.initials: D
authors.lastname: Kahn
mesh_terms: D000369:Aged, 80 and over; D002389:Catatonia / Q000188:drug therapy* / Q000523:psychology*; D003865:Major Depressive Disorder / Q000523:psychology*; D015259:Dopamine Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008559:Memantine / Q000627:therapeutic use*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D016896:Treatment Outcome
chemical_list: D015259:Dopamine Agents; D016194:Receptors, N-Methyl-D-Aspartate; D008559:Memantine