title: Sensing cellular stress through STIM proteins.
abstract: In response to decreasing Ca2+ levels in the endoplasmic reticulum, STIM proteins couple with Orai channels in the plasma membrane, leading to Ca2+ influx into the cell. In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis.
authors.affiliation: Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Soboloff
authors.forename: Muniswamy
authors.initials: M
authors.lastname: Madesh
authors.forename: Donald L
authors.initials: DL
authors.lastname: Gill
mesh_terms: D015374:Biosensing Techniques; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D013312:Stress, Physiological / Q000502:physiology*; D013696:Temperature
chemical_list: D015220:Calcium Channels; D008565:Membrane Proteins; D002118:Calcium