title: Incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients.
abstract: BACKGROUND
  Renal allograft recipients are reported to have a higher incidence of malignancy than the general population. This single hospital-based study examined the incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients.
  
  
  METHODS
  Among 453 women receiving renal transplantation from January 1990 to December 2008, 5 patients were diagnosed with cervical carcinoma. Medical records of these 5 patients were retrospectively reviewed, and clinicopathologic data were collected and analyzed.
  
  
  RESULTS
  The incidence of cervical carcinoma in renal transplant recipients was 58.1 out of 100,000 per year, which is 3.5 times higher than in the general Korean population. The mean interval between the time of renal transplantation and the time of cervical carcinoma diagnosis was 80.7 months. After a median follow-up of 96.2 months, there was no recurrence of the disease or death. In 4 patients who were positive from human papillomavirus in situ hybridization (HPV ISH), high or probably high risk HPV DNA was detected in all. Punctate staining of HPV ISH was detected in 3 out of 4 patients.
  
  
  CONCLUSIONS
  Higher incidence of cervical carcinoma is expected in renal transplant recipients, so appropriate surveillance is needed to ensure early detection and treatment of cervical carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Sung Taek
authors.initials: ST
authors.lastname: Park
authors.forename: Min Jong
authors.initials: MJ
authors.lastname: Song
authors.forename: Jong Sup
authors.initials: JS
authors.lastname: Park
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Hur
authors.forename: Chung Won
authors.initials: CW
authors.lastname: Lee
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D009367:Neoplasm Staging; D011159:Population Surveillance; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology*