title: Synthesis and antimicrobial activity of quaternary ammonium silane coupling agents.
abstract: Fourteen novel silane coupling agents with a quaternary ammonium group introduced into the molecule, [CH(2)=CHCH(2)N(+)(CH(3))(C(n)H(2n+1))(CH(2))(3)Si(OCH(3))(3)]X(-) (n-X, n=10-18, X=Cl, Br, or I), were synthesized with the aim of using these agents to make material surfaces antimicrobial for a long period of time. Measurements of the minimum inhibitory concentrations (MIC) against 12 kinds of fungi and bacteria revealed that the coupling agent with a C(10) alkyl chain and Cl- or Br- counter-ion (10-Cl or 10-Br) has the highest antimicrobial activity among the n-X agents synthesized, but 14-Cl and 14-Br showed the highest activity on a modified porcelain plate.
authors.affiliation: Faculty of Engineering, Tokyo University of Science, Tokyo, Japan. yoshino@ci.kagu.tus.ac.jp
authors.forename: Norio
authors.initials: N
authors.lastname: Yoshino
authors.forename: Shigenori
authors.initials: S
authors.lastname: Sugaya
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Yoh-hei
authors.initials: YH
authors.lastname: Yamaguchi
authors.forename: Yukishige
authors.initials: Y
authors.lastname: Kondo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kawada
authors.forename: Toshio
authors.initials: T
authors.lastname: Teranaka
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D015169:Colony Count, Microbial; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012821:Silanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D000644:Quaternary Ammonium Compounds; D012821:Silanes