title: [Intensity of lipid peroxidation and antioxidant protection system indices during re-adaptation period after long-term space flights at the international space station].
abstract: In the blood serum of seventeen members of crews which participated in 14 orbital expeditions to the International Space Station with the duration of 125 to 217 days, during the pre-flight period and on the day of landing on the 1st, 7th and 14th days of the rehabilitation period (RP) the content of LPO products was determined, namely diene conjugates (DC), malon dialdehyde (MDA), shiffbases (SB) and the main lipid oxidant - tocopherol (TP). The group of astronauts who made landing in the Space Shuttle spacecraft (8 persons) and the group of astronauts who accomplished space mission in the Soyus TM spacecraft (9 persons) demonstrated a decrease in DC and MDA levels with a rise in TF concentration in the course of the rehabilitation period. Changes in the group of the American spacecraft astronauts were more pronounced. LPO inhibition during the rehabilitation period is recognized [treated] as an adequate reaction to the stress caused by re-adaptation to the ground conditions. Also are discussed probable mechanisms of intergroup differencies in LPO intensity degree: biomembrane phase state changing under the influence of overloads during de-orbiting and stress response intensity during landing in different types of spacecraft.
authors.forename: O A
authors.initials: OA
authors.lastname: Zhuravleva
authors.forename: B V
authors.initials: BV
authors.lastname: Morukov
authors.forename: A A
authors.initials: AA
authors.lastname: Markin
authors.forename: L V
authors.initials: LV
authors.lastname: Vostrikova
authors.forename: I V
authors.initials: IV
authors.lastname: Zabolotskaia
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D018480:Astronauts; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D013026:Space Flight; D013312:Stress, Physiological / Q000502:physiology*; D013997:Time Factors
chemical_list: D000975:Antioxidants