title: Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata.
abstract: Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC(50) value of 8 μg/mL each.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Murayama
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Imae
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takada
authors.forename: Jo
authors.initials: J
authors.lastname: Kikuchi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Shigeru
authors.initials: S
authors.lastname: Okada
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
mesh_terms: D000818:Animals; D002401:Cathepsin B / Q000037:antagonists & inhibitors*; D015853:Cysteine Proteinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D015853:Cysteine Proteinase Inhibitors; D013256:Steroids; D002401:Cathepsin B