title: [-174 G/C polymorphism of interleukin 6 gene in women with type 1 diabetes].
abstract: BACKGROUND
  A polymorphism located in the promoter region (-174 G/C) of interleukin 6 (IL-6) has been linked to early onset of type 1 diabetes (T1D) and increased body mass index (BMI).
  
  
  OBJECTIVE
  To evaluate the possible association of this -IL-6 gene 174 GIC polymorphism with T1D, BMI and metabolic control in T1D patients in a case-control study.
  
  
  METHODS
  -174 G I C polymorphisms were analyzed by polymerase chain reaction and restriction fragment length polymorphism in 145 women with T1D and 103 healthy controls. BMI and BMI-Z-scores were tabulated and metabolic control was recorded.
  
  
  RESULTS
  There was a higher frequency for the C allele in T1D patients compared with the control group (21% versus 14.1%, p = 0.047). No significant differences in genotype frequencies for the -174 GIC polymorphism of IL-6 gene between patients with T1D and controls, were observed. There were no significant associations with T1D and BMI.
  
  
  CONCLUSIONS
  A higher frequency of C allele in women with T1D was the only finding in this series, suggesting that the polymorphic variant is not related to weight gain in these patients.
authors.affiliation: Laboratorio de Genómica Nutricional, Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago, Chile. fperez@med.uchile.cl
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez-Bravo
authors.forename: Francisca
authors.initials: F
authors.lastname: Soto M
authors.forename: Patricia
authors.initials: P
authors.lastname: López A
authors.forename: Francisca
authors.initials: F
authors.lastname: Eyzaguirre C
authors.forename: Ethel
authors.initials: E
authors.lastname: Codner
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D015430:Weight Gain / Q000235:genetics; D055815:Young Adult