title: Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity.
abstract: A series of new quinolone-3-carboxylic acids featuring a hydroxyl group at C-5 position were synthesized and evaluated for their in vitro activity against HIV in C8166 cell culture. All the compounds showed anti-HIV-1 activity with low micromolar to submicromolar EC(50) values. The most active compound 2k exhibited activity against wild-type HIV-1 with an EC(50) value of 0.13 μΜ. Preliminary structure-activity relationship of the newly synthesized quinolone analogues was also investigated. Further docking study revealed that the anti-HIV activity of these compounds might involve a two-metal chelating mechanism.
authors.affiliation: Department of Chemistry, Fudan University, Shanghai 200433, PR China.
authors.forename: Qiu-Qin
authors.initials: QQ
authors.lastname: He
authors.forename: Shuang-Xi
authors.initials: SX
authors.lastname: Gu
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Hai-Qiu
authors.initials: HQ
authors.lastname: Wu
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Fen-Er
authors.initials: FE
authors.lastname: Chen
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy* / Q000473:pathology; D006679:HIV Seropositivity; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008958:Models, Molecular; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D002264:Carboxylic Acids; D015363:Quinolones