title: A new staurosporine analog from Actinomycetes Streptomyces sp. (172614).
abstract: A new staurosporine analog, 10'-{5″-[(methoxycarbonyl)amino]-2″-methyl}-phenylaminocarbonylstaurosporine (1), together with staurosporine (2), was obtained from the culture broth of Actinomycetes Streptomyces sp. (172614). Their structures were elucidated by comprehensive spectroscopic analysis including UV, MS, NMR, and CD spectra. Pharmacological experiments revealed that 1 and 2 showed significant cytotoxicity against human colon tumor cell HCT-116.
authors.affiliation: College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Li
authors.forename: Jin-Shan
authors.initials: JS
authors.lastname: Tang
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Rong
authors.initials: R
authors.lastname: Ding
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Kui
authors.initials: K
authors.lastname: Hong
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: C560971:10'-(5''-((methoxycarbonyl)amino)-2'-methyl)phenylaminocarbonylstaurosporine; D000970:Antineoplastic Agents; D019311:Staurosporine