title: Lesions to the posterior insular cortex cause dysarthria.
abstract: BACKGROUND
  Up to now, there are few systematic studies in a sufficient number of patients with lesions involving the insular cortex (IC) examining whether damage of the IC is directly related to dysarthria. Thus, this is the first study applying modern voxel-lesion behaviour mapping (VLBM) aimed to examine whether the IC is involved in dysarthria - and if so - which part of the IC is involved.
  
  
  METHODS
  Twenty-five patients with acute stroke lesions affecting the IC and peri-insular region were investigated employing VLBM analysis.
  
  
  RESULTS
  Present data indicated that dysarthria is associated with stroke lesions affecting the right- and left-sided posterior IC.
  
  
  CONCLUSIONS
  Owing to the known extensive spectrum of cortical and subcortical somatosensory and motor connections, it seems that the IC might be one region involved in the generation of speech motor execution.
authors.affiliation: Department of Neurology, Johannes Gutenberg University, Germany. baierb@uni-mainz.de
authors.forename: B
authors.initials: B
authors.lastname: Baier
authors.forename: P
authors.initials: P
authors.lastname: zu Eulenburg
authors.forename: O
authors.initials: O
authors.lastname: Glassl
authors.forename: M
authors.initials: M
authors.lastname: Dieterich
mesh_terms: D000368:Aged; D000465:Algorithms; D002545:Brain Ischemia / Q000150:complications* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000098:blood supply / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging; D004292:Dominance, Cerebral; D004401:Dysarthria / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013382:Subtraction Technique; D013702:Temporal Lobe / Q000098:blood supply / Q000503:physiopathology