title: HIV-associated multicentric Castleman disease.
abstract: OBJECTIVE
  HIV-associated multicentric Castleman disease (HIV MCD) is a rare lymphoproliferative disorder, the incidence of which appears to be increasing in the highly active antiretroviral therapy era. Current knowledge of the disease is limited and this review will discuss what is known about the pathophysiology, diagnosis, management, and prognosis of HIV MCD.
  
  
  RESULTS
  HIV MCD has been shown to be associated with infection with human herpesvirus-8. Vascular endothelial growth factor and the cytokine interleukin-6 (IL-6) are also thought to play a role in the pathogenesis of MCD. Currently, rituximab is often used alone or in combination with chemotherapy for treatment of MCD. Novel monoclonal antibodies targeting IL-6 and the IL-6 receptor are also being studied for the management of this disease.
  
  
  CONCLUSIONS
  Because HIV MCD is an uncommon diagnosis, comprehensive clinical studies have not been done, and understanding of the disease is incomplete. Further studies are needed to make definitive conclusions regarding optimal treatment of HIV MCD.
authors.affiliation: Division of Hematology Oncology, Center for Clinical AIDS Research and Education, University of California Los Angeles, Los Angeles, California 90095, USA. dreddy@mednet.ucla.edu
authors.forename: Deepa
authors.initials: D
authors.lastname: Reddy
authors.forename: Ronald
authors.initials: R
authors.lastname: Mitsuyasu
mesh_terms: D017088:AIDS-Related Opportunistic Infections; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D005871:Castleman Disease / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy / Q000821:virology*; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000150:complications*; D006566:Herpesviridae Infections / Q000150:complications; D019288:Herpesvirus 8, Human; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism
chemical_list: D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D015850:Interleukin-6