title: Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates.
abstract: 2H-Chromenes were synthesized from salicylaldehyde using potassium vinylic borates in the presence of secondary amines. We synthesized these 2H-chromene derivatives as a part of an ongoing project to develop inhibitors for TGF-β receptors. Potassium vinyl trifluoroborates react with salicylaldehydes at 80 °C in the presence of a secondary amine and produced 2-substituted 2H-chromene derivatives with a 70-90% yield.
authors.affiliation: Department of Nuclear Medicine Albert Einstein College of Medicine, Bronx, NY 10461, United States.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Todd
authors.initials: T
authors.lastname: Evans
authors.forename: Bhaskar C
authors.initials: BC
authors.lastname: Das