title: Impact of anticardiolipin antibody on the outcome of in vitro fertilization and embryo transfer.
abstract: OBJECTIVE
  To investigate the impact of anticardiolipin antibody (ACA) on the outcome of in vitro fertilization and embryo transfer (IVF-ET).
  
  
  METHODS
  A total of 76 infertile women positive for anticardiolipin antibody (ACA+ group) and 819 controls negative for anticardiolipin antibody (ACA- group) undergoing IVF-ET in the First Affiliated Hospital, to Sun Yat-Sen University, were retrospectively analyzed. Women were diagnosed as having pure tubal factor infertility.
  
  
  RESULTS
  The proportion of patients with a history of spontaneous abortion in the ACA+ group was significantly higher than that in ACA- group (19.7% versus 8.9%). The IVF rate, pregnancy rate and implantation rate in the ACA+ group were markedly lower than those in the ACA- group (75.5% versus 78.9%, 31.3% versus 48.6% and 16.1% versus 28.1%, respectively). Furthermore, the incidence of pregnancy loss in the ACA+ group was higher than that in the ACA- group (32.0% versus 15.1%).
  
  
  CONCLUSIONS
  ACA-positive patients had significantly decreased IVF rate, pregnancy rate and implantation rate and high risk of abortion. Therefore, ACA positivity predicts poor outcome of IVF-ET, and pre-treatment to lower ACA level may be clinically beneficial for patients receiving IVF-ET.
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Zhong
authors.forename: Ying
authors.initials: Y
authors.lastname: Ying
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Wu
authors.forename: Can-Quan
authors.initials: CQ
authors.lastname: Zhou
authors.forename: Yan-Wen
authors.initials: YW
authors.lastname: Xu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Sheng
authors.forename: Jing
authors.initials: J
authors.lastname: Li
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000009:adverse effects* / Q000706:statistics & numerical data; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects* / Q000706:statistics & numerical data; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D055815:Young Adult
chemical_list: D017153:Antibodies, Anticardiolipin