title: [Expression and its significance of Cyclin D1 in oral squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression and significance of Cyclin D1 in oral squamous cell ma (OSCC).
  
  
  METHODS
  A immunohistochemistry method, Envosion, was employed to test the manifesting Cyclin D1 in pathological slices of 50 OSCC cases and 10 normal cases, and the results was treated with statistical lysis.
  
  
  RESULTS
  In 50 OSCC cases, Cyclin D1 mainly manifested in karyon, and a little in cytoplasm. manifesting rates of Cyclin D1 in the samples was 80.0%, which was significantly higher than the manifesting of 20.0% in normal oral mucous membrane (P < 0.01). The manifestation of Cyclin D1 was correlated with rent pathological grades, clinical phases and lymph node metastasis (P < 0.05).
  
  
  CONCLUSIONS
  The abnormal tation of Cyclin D1 is closely related with the occurrence and development of OSCC. Therefore, it can subsidiary index for OSCC treatment and prognosis.
authors.affiliation: Dept. of Stomatology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Xing
authors.forename: Pei-Rong
authors.initials: PR
authors.lastname: Shi
authors.forename: Xian-Jiu
authors.initials: XJ
authors.lastname: Chen
authors.forename: Dong-Ning
authors.initials: DN
authors.lastname: He
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Li
authors.forename: Xin-Rong
authors.initials: XR
authors.lastname: Nan
mesh_terms: D002294:Carcinoma, Squamous Cell; D019938:Cyclin D1; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D009061:Mouth Mucosa; D009062:Mouth Neoplasms; D011379:Prognosis
chemical_list: D019938:Cyclin D1