title: Functional role for transporter isoforms in optimizing membrane transport.
abstract: Quantitative analysis of carrier parameters demonstrates that with decreasing substrate concentration the optimal strength of substrate-carrier interaction which maximizes the flux across the membrane increases and requires less fine-tuning than at higher concentrations of the substrate.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Berezhkovskii
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Lizunov
authors.forename: Joshua
authors.initials: J
authors.lastname: Zimmerberg
authors.forename: Sergey M
authors.initials: SM
authors.lastname: Bezrukov
mesh_terms: D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry / Q000378:metabolism
chemical_list: D026901:Membrane Transport Proteins; D020033:Protein Isoforms