title: ACE gene polymorphism in premature neonates with respiratory distress syndrome.
abstract: The purpose of this study was to investigate the relationship between angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism and respiratory distress syndrome (RDS) in premature neonates. The patient group consisted of 101 premature neonates born before 37 weeks of gestation and diagnosed as RDS. The control group consisted of 100 premature neonates born before 37 weeks of gestation, but was not diagnosed as RDS. Genomic DNA from patients and controls was analyzed by polymerase chain reaction. D/D genotype was significantly higher in patient group (60.4% patients vs. 37.0% controls, p<0.05), whereas in the controls I/D genotype was markedly higher (33.7% patients vs. 61.0% controls, p<0.05). However, no marked change was observed with I/I genotype (5.9% patients vs. 2.0% controls). A significant increase of D alleles was observed in patients, whereas I allele was higher in controls (p<0.05). These results demonstrated the existence of higher frequency of the D/D genotype and D allele in premature neonates with RDS. These data may suggest that carriers of the D/D genotype and D allele are at increased risk of RDS development in premature neonates.
authors.affiliation: Department of Pediatrics, University of Gaziantep, Gaziantep, Turkey.
authors.forename: Sevgi
authors.initials: S
authors.lastname: Yimenicioglu
authors.forename: Serdar
authors.initials: S
authors.lastname: Oztuzcu
authors.forename: Ercan
authors.initials: E
authors.lastname: Sivasli
authors.forename: Mehri
authors.initials: M
authors.lastname: Igci
authors.forename: Yusuf Ziya
authors.initials: YZ
authors.lastname: Igci
authors.forename: Seniz
authors.initials: S
authors.lastname: Demiryürek
authors.forename: Esma
authors.initials: E
authors.lastname: Ozkara
authors.forename: Bulent
authors.initials: B
authors.lastname: Gogebakan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Arslan
authors.forename: Mehmet Yavuz
authors.initials: MY
authors.lastname: Coskun
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000235:genetics*; D019102:Infant, Very Low Birth Weight; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012127:Respiratory Distress Syndrome, Newborn / Q000235:genetics*; D055815:Young Adult
chemical_list: D007703:Peptidyl-Dipeptidase A