title: Antidiabetic and antiacetylcholinesterase effects of ethyl acetate fraction of Chaenomeles sinensis (Thouin) Koehne fruits in streptozotocin-induced diabetic rats.
abstract: The present study was intended to examine the effects of the supplementation of active α-glucosidase, α-amylase and lipase inhibitory ethyl acetate (CSE) fraction from the fruits of Chaenomeles sinensis (Thouin) Koehne on blood glucose (BG), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransaminase (AST), acetylcholinesterase (AChE) and antioxidant levels. The diabetic rats were treated orally with CSE at the doses of 50 and 100 mg/kg bw for 14 days. BG, TC, TG, HDL-C, ALT, AST and AChE levels were significantly reduced; on the other hand antioxidant levels were significantly increased in the treated groups. These observations suggest protective effects of CSE against STZ-induced diabetic dementia model.
authors.affiliation: Department of Biology, Kongju National University, Kongju 314-701, Republic of Korea.
authors.forename: Sandesh
authors.initials: S
authors.lastname: Sancheti
authors.forename: Shruti
authors.initials: S
authors.lastname: Sancheti
authors.forename: Sung-Yum
authors.initials: SY
authors.lastname: Seo
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000201:enzymology; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D005638:Fruit / Q000737:chemistry; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects / Q000201:enzymology; D008049:Lipase / Q000037:antagonists & inhibitors; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027824:Rosaceae / Q000737:chemistry*; D013311:Streptozocin / Q000494:pharmacology; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
chemical_list: D000085:Acetates; D000975:Antioxidants; D001786:Blood Glucose; D002800:Cholinesterase Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013311:Streptozocin; C007650:ethyl acetate; D008049:Lipase; D000110:Acetylcholinesterase; D000516:alpha-Amylases