title: Significance of the platelet-derived growth factor in periodontal tissue regeneration.
abstract: OBJECTIVE
  The aim was to review the significance of the platelet derived growth factor (PGDF) in periodontal tissue regeneration.
  
  
  RESULTS
  Databases were searched using the following terms in different combinations: "growth factors", "guided bone regeneration", "guided tissue regeneration", "periodontal", "platelet rich plasma" and "platelet derived growth factor". Titles and abstracts of articles obtained using the above-described criteria were then screened by the authors and checked for agreement. The next step was to hand-search the reference lists of original and review studies that were found to be relevant in the previous step. PDGF has a stimulatory effect on the DNA replication and chemotaxis of osteoblasts, fibroblasts, leukocytes, monocytes, neutrophils periodontal and alveolar bone cells. Proliferation of mesenchymal stem cells is also promoted by supplement treatment with PDGF. PDGF in combination with other growth factors enhances periodontal tissue repair.
  
  
  CONCLUSIONS
  The PDGF plays a significant role in periodontal bone and tissue regeneration.
authors.affiliation: Eng. AB Research Chair for Growth Factors and Bone Regeneration, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Fawad
authors.initials: F
authors.lastname: Javed
authors.forename: Mansour
authors.initials: M
authors.lastname: Al-Askar
authors.forename: Abdulaziz
authors.initials: A
authors.lastname: Al-Rasheed
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Hezaimi
mesh_terms: D000818:Animals; D002633:Chemotaxis / Q000187:drug effects; D048091:Guided Tissue Regeneration; D006801:Humans; D010510:Periodontal Diseases / Q000188:drug therapy*; D010519:Periodontium / Q000166:cytology / Q000502:physiology*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D053657:Platelet-Rich Plasma; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
chemical_list: D010982:Platelet-Derived Growth Factor