title: Chemiluminescent nanomicelles for imaging hydrogen peroxide and self-therapy in photodynamic therapy.
abstract: Hydrogen peroxide is a signal molecule of the tumor, and its overproduction makes a higher concentration in tumor tissue compared to normal tissue. Based on the fact that peroxalates can make chemiluminescence with a high efficiency in the presence of hydrogen peroxide, we developed nanomicelles composed of peroxalate ester oligomers and fluorescent dyes, called peroxalate nanomicelles (POMs), which could image hydrogen peroxide with high sensitivity and stability. The potential application of the POMs in photodynamic therapy (PDT) for cancer was also investigated. It was found that the PDT-drug-loaded POMs were sensitive to hydrogen peroxide, and the PDT drug could be stimulated by the chemiluminescence from the reaction between POMs and hydrogen peroxide, which carried on a self-therapy of the tumor without the additional laser light resource.
authors.affiliation: Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.forename: Luzhong
authors.initials: L
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
authors.forename: Xiqun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D005456:Fluorescent Dyes; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism* / Q000627:therapeutic use*; D049449:Luminescence; D008163:Luminescent Measurements / Q000379:methods*; D008823:Micelles; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy
chemical_list: D005456:Fluorescent Dyes; D008823:Micelles; D006861:Hydrogen Peroxide