title: A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development.
abstract: The allostatic load (AL) model represents an interdisciplinary approach to comprehensively conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle. This article first reviews the AL model, followed by interactions among early adversity, genetics, environmental toxins, as well as distinctions among sex, gender, and sex hormones as integral antecedents of AL. We next explore perspectives on severe mental illness, dementia, and caregiving as unique human models of AL that merit future investigations in the field of developmental psychopathology. A complimenting transdisciplinary perspective is applied throughout, whereby we argue that the AL model goes beyond traditional stress-disease theories toward the advancement of person-centered research and practice that promote not only physical health but also mental health.
authors.affiliation: University of Montreal, Montreal, Canada. robert.juster@mail.mcgill.ca
authors.forename: Robert-Paul
authors.initials: RP
authors.lastname: Juster
authors.forename: Gustav
authors.initials: G
authors.lastname: Bizik
authors.forename: Martin
authors.initials: M
authors.lastname: Picard
authors.forename: Genevieve
authors.initials: G
authors.lastname: Arsenault-Lapierre
authors.forename: Shireen
authors.initials: S
authors.lastname: Sindi
authors.forename: Lyane
authors.initials: L
authors.lastname: Trepanier
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Marin
authors.forename: Nathalie
authors.initials: N
authors.lastname: Wan
authors.forename: Zoran
authors.initials: Z
authors.lastname: Sekerovic
authors.forename: Catherine
authors.initials: C
authors.lastname: Lord
authors.forename: Alexandra J
authors.initials: AJ
authors.lastname: Fiocco
authors.forename: Pierrich
authors.initials: P
authors.lastname: Plusquellec
authors.forename: Bruce S
authors.initials: BS
authors.lastname: McEwen
authors.forename: Sonia J
authors.initials: SJ
authors.lastname: Lupien
mesh_terms: D052636:Allostasis / Q000502:physiology*; D006801:Humans; D019369:Life; D008016:Life Change Events; D001523:Mental Disorders / Q000503:physiopathology*; D013315:Stress, Psychological / Q000503:physiopathology*