title: Fast-spiking interneurons have an initial orientation bias that is lost with vision.
abstract: We found that in mice, following eye opening, fast-spiking, parvalbumin-positive GABAergic interneurons had well-defined orientation tuning preferences and that subsequent visual experience broadened this tuning. Broad inhibitory tuning was not required for the developmental sharpening of excitatory tuning but did precede binocular matching of excitatory orientation tuning. We propose that experience-dependent broadening of inhibition is a candidate for initiating the critical period of excitatory binocular plasticity in developing visual cortex.
authors.affiliation: Department of Neurobiology, University of California, Los Angeles, Los Angeles, California, USA.
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Kuhlman
authors.forename: Elaine
authors.initials: E
authors.lastname: Tring
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Trachtenberg
mesh_terms: D000200:Action Potentials / Q000235:genetics / Q000502:physiology*; D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D015982:Bias; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D007395:Interneurons / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009949:Orientation; D010320:Parvalbumins / Q000235:genetics; D018408:Patch-Clamp Techniques; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time / Q000502:physiology; D014785:Vision, Ocular / Q000502:physiology*; D014793:Visual Cortex / Q000166:cytology; D014795:Visual Pathways / Q000502:physiology
chemical_list: D010320:Parvalbumins