title: Clinical features of Bacteroides bacteremia and their association with colorectal carcinoma.
abstract: OBJECTIVE
  We investigated the clinical features of Bacteroides bacteremia for 5 years to determine the risk factors for mortality and to ascertain whether bacteremia due to Bacteroides spp. is associated with colorectal carcinoma.
  
  
  METHODS
  This study comprised a review of all patients with Bacteroides bacteremia at a teaching hospital in Tokyo from April 2003 to March 2008. We also conducted a case-control study between Bacteroides bacteremia and bacteremia due to other pathogens.
  
  
  RESULTS
  During the study period, 25 cases of bacteremia were due to Bacteroides spp. Bacteroides bacteremia was associated with a high mortality rate (24%). Malignancy (76%) was the major comorbidity, followed by a history of surgery (40%). Colorectal carcinoma was the most frequent (n = 8, 32%) of the comorbid malignancies and was recognized as the primary infection site in six cases. Prevalence of colorectal carcinoma as comorbidity was significantly higher in Bacteroides bacteremia than in other bacteremia.
  
  
  CONCLUSIONS
  In the Bacteroides bacteremia cases of this study, colorectal carcinoma was the major comorbidity and primary infection site. Colorectal carcinoma screening in Bacteroides bacteremia patients is potentially an important diagnostic marker for the early detection of this infection in the future.
authors.affiliation: Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshino
authors.forename: T
authors.initials: T
authors.lastname: Kitazawa
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Tatsuno
authors.forename: S
authors.initials: S
authors.lastname: Yanagimoto
authors.forename: S
authors.initials: S
authors.lastname: Okugawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ota
authors.forename: H
authors.initials: H
authors.lastname: Yotsuyanagi
mesh_terms: D000368:Aged; D016470:Bacteremia / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D001439:Bacteroides / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D001442:Bacteroides Infections / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D002277:Carcinoma / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014041:Tokyo