title: Total tooth loss and systemic correlates of inflammation: role of obesity.
abstract: Obesity and edentulism are both associated with multiple systemic disorders with an inflammatory background including periodontal diseases. This study aimed to evaluate the different impact of obesity on inflammation in dentate and toothless subjects. The data came from the population-based, cross-sectional study SHIP (Study of Health in Pomerania). We determined anthropometric measures including BMI, waist-to-hip ratio (WHR), diagnostic periodontal parameters, and systemic metabolites. It was shown that measures of systemic markers of inflammation and lipid or glucose metabolism (P < 0.001) were increased with higher WHR. When adjusted for age, sex, smoking, diabetes, education, physical activity, and last dentist's appointment, C-reactive protein (CRP), fibrinogen, and leukocyte count were significantly related to WHR increasing from the first to the fourth WHR quartile (P < 0.001) as well as to the BMI. In both dentate and edentulous subjects higher WHR contributes significantly to increasing systemic CRP and fibrinogen with sex differences. In toothless subjects, while still dependent on increasing WHR, the inflammatory markers CRP and fibrinogen were higher than in dentate subjects, thereby revealing effect modification between sex and edentulism (P < 0.010). In conclusion, subjects with total tooth loss, although devoid of periodontal inflammation, may exhibit increased levels of systemic inflammatory mediators. Possible implications are discussed with respect to obesity and its relationship to inflammation.
authors.affiliation: Dental Clinics, Department of Periodontology, Ernst Moritz Arndt University Greifswald, Greifswald, Germany. meiselp@uni-greifswald.de
authors.forename: Peter
authors.initials: P
authors.lastname: Meisel
authors.forename: Peter
authors.initials: P
authors.lastname: Wilke
authors.forename: Reiner
authors.initials: R
authors.lastname: Biffar
authors.forename: Birte
authors.initials: B
authors.lastname: Holtfreter
authors.forename: Henry
authors.initials: H
authors.lastname: Wallaschofski
authors.forename: Thomas
authors.initials: T
authors.lastname: Kocher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009066:Mouth, Edentulous / Q000453:epidemiology / Q000209:etiology*; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D016388:Tooth Loss / Q000453:epidemiology / Q000209:etiology*; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein