title: Type 2 diabetes and late-onset Alzheimer's disease.
abstract: OBJECTIVE
  To confirm in a cohort recruited in 1999-2001 our finding in a cohort recruited in 1992-1994 relating type 2 diabetes (T2D) to late-onset Alzheimer's disease (LOAD).
  
  
  METHODS
  Participants were 1,488 persons aged 65 years and older without dementia at baseline from New York City. T2D was ascertained by self-report. Dementia and LOAD were ascertained by standard research procedures. Proportional hazard regression was used for analyses relating T2D and LOAD.
  
  
  RESULTS
  The prevalence of T2D was 17%. There were 161 cases of dementia and 149 cases of LOAD. T2D was related to dementia (hazard ratio = 1.7; 95% confidence interval = 1.4-2.9) and LOAD (1.6; 1.0-2.6) after adjustment for age, sex, education, ethnic group and apolipoprotein E ε4. This association was weaker when only AD - excluding cases of mixed dementia - was considered (hazard ratio = 1.3; 95% confidence interval = 0.8-2.2).
  
  
  CONCLUSIONS
  T2D is associated with LOAD. Cerebrovascular disease may be an important mediator.
authors.affiliation: Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, 630 West 168th St., New York, NY 10032, USA.
authors.forename: D
authors.initials: D
authors.lastname: Cheng
authors.forename: J
authors.initials: J
authors.lastname: Noble
authors.forename: M X
authors.initials: MX
authors.lastname: Tang
authors.forename: N
authors.initials: N
authors.lastname: Schupf
authors.forename: R
authors.initials: R
authors.lastname: Mayeux
authors.forename: J A
authors.initials: JA
authors.lastname: Luchsinger
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D001057:Apolipoproteins E / Q000235:genetics; D044383:Black People; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology*; D004522:Educational Status; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D006630:Hispanic or Latino; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009519:New York City / Q000453:epidemiology; D016016:Proportional Hazards Models; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D001741:Black or African American
chemical_list: D001057:Apolipoproteins E