title: [Preliminary study on rt-PA intravenous thrombolysis for elderly Chinese patients with acute stroke].
abstract: OBJECTIVE
  To assess the efficacy and safety of alteplase in acute ischemic stroke for Chinese patients aged 75 years and elder.
  
  
  METHODS
  A total of 32 patients aged 75 years and elder are selected from our departmental database of thrombolytic therapy from January 2005 to December 2008. The primary end points were the proportion of patients with a modified Rankin scale (mRS) score of 0 to 1 at 3 months and the incidence of symptomatic intracranial hemorrhage (sICH) within 36 hours.
  
  
  RESULTS
  Among them, 12 had a mRS of 0 to 1 at 3 month and sICH occurred in 4 patients within 36 hours. The results were similar to those of NINDS (National Institute of Neurological Disorders & Stroke) study.
  
  
  CONCLUSIONS
  An intravenous infusion of rt-PA at 0.6 mg/kg is probably efficacious and safe in the elder Chinese patients with acute ischemic stroke.
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.forename: Xin-yu
authors.initials: XY
authors.lastname: Zhang
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Fan
authors.forename: Xiao-gang
authors.initials: XG
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy