title: Exploring the relationship between white matter microstructure and working memory functioning following stroke: a single case study of computerized cognitive training.
abstract: Cognitive impairment is a well-known consequence of acquired brain injuries, including stroke. Computerized cognitive training (CCT) is a rehabilitation approach intended to enhance cognitive functioning. It is unclear whether CCT leads to generalized cognitive improvements in daily life functioning, or if the subjects improve performance only on the exercises involved in the training. The current study explores whether fractional anisotropy (FA), a measure of white matter microstructure, may serve as an indirect biological indicator of enhanced neuropsychological functioning, particularly working memory, following CCT. The findings suggest a possible relationship between changes in FA measures and working memory.
authors.affiliation: Centre for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway. j.e.nordvik@psykologi.uio.no
authors.forename: Jan E
authors.initials: JE
authors.lastname: Nordvik
authors.forename: Anne-Kristine
authors.initials: AK
authors.lastname: Schanke
authors.forename: Kristine
authors.initials: K
authors.lastname: Walhovd
authors.forename: Anders
authors.initials: A
authors.lastname: Fjell
authors.forename: Håkon
authors.initials: H
authors.lastname: Grydeland
authors.forename: Nils I
authors.initials: NI
authors.lastname: Landrø
mesh_terms: D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009483:Neuropsychological Tests; D020521:Stroke / Q000473:pathology / Q000523:psychology*; D000071939:Stroke Rehabilitation