title: Molecular diagnosis of Aspergillus fumigatus endocarditis.
abstract: A 66-year-old male with ischaemic cardiomyopathy and chronic lymphocytic leukemia developed signs of severe systemic inflammatory response syndrome. Serial blood cultures were negative and a SeptiFast test detected the presence of Aspergillus fumigatus DNA. Afterwards, detection of galactomannan and 1,3-β-D-glucan showed a positive result. Autopsy revealed the presence of branched fungal structures suggestive of Aspergillus.
authors.affiliation: Unidad de Gestión de Microbiología, Hospital Universitario de Valme, Ctra Cádiz s/n, Bellavista, 41014 Sevilla, Spain. jcpalomares@us.es
authors.forename: José C
authors.initials: JC
authors.lastname: Palomares
authors.forename: Samuel
authors.initials: S
authors.lastname: Bernal
authors.forename: María
authors.initials: M
authors.lastname: Marín
authors.forename: Victoria Pérez
authors.initials: VP
authors.lastname: Holgado
authors.forename: Carmen
authors.initials: C
authors.lastname: Castro
authors.forename: Willy Pinto
authors.initials: WP
authors.lastname: Morales
authors.forename: Estrella
authors.initials: E
authors.lastname: Martin
mesh_terms: D000368:Aged; D001228:Aspergillosis / Q000175:diagnosis* / Q000382:microbiology*; D001232:Aspergillus fumigatus / Q000235:genetics / Q000302:isolation & purification*; D001344:Autopsy; D009202:Cardiomyopathies / Q000150:complications; D004271:DNA, Fungal / Q000097:blood*; D004696:Endocarditis / Q000175:diagnosis* / Q000382:microbiology*; D017809:Fatal Outcome; D005690:Galactose / Q000031:analogs & derivatives; D006651:Histocytochemistry; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications; D008297:Male; D008351:Mannans / Q000097:blood; D008853:Microscopy; D011509:Proteoglycans; D047071:beta-Glucans / Q000097:blood
chemical_list: D004271:DNA, Fungal; D008351:Mannans; D011509:Proteoglycans; D047071:beta-Glucans; C012990:galactomannan; C010770:polysaccharide-K; D005690:Galactose