title: Mantle cell lymphoma mainly involving thoracic lesions: two case reports.
abstract: Most mantle cell lymphoma patients show remarkable disseminated disease at the initial diagnosis. We describe two cases of mantle cell lymphoma mainly involving thoracic lesions at the initial presentation of the disease. The clinical presentations were right hilar lymphadenopathy in one case and right pleural thickness in the other. The diagnosis of mantle cell lymphoma was confirmed by immunohistochemistry, including CD5, CD20, and cyclin D1, and the presence of t(11 ; 14)(q13 ; q32) by fluorescence in situ hybridization. These thoracic manifestations at the initial diagnosis should be taken into consideration for the clinical spectrum of mantle cell lymphoma.
authors.affiliation: The First Department of Internal Medicine, Shinshu University School of Medicine, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kosaka
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Toshirou
authors.initials: T
authors.lastname: Fukushima
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Wada
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Agatsuma
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Shintorou
authors.initials: S
authors.lastname: Kanda
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shimojo
authors.forename: Shirou
authors.initials: S
authors.lastname: Horie
authors.forename: Naoko
authors.initials: N
authors.lastname: Asano
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000378:metabolism; D000971:Antineoplastic Combined Chemotherapy Protocols; D018956:CD5 Antigens / Q000378:metabolism; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D019938:Cyclin D1 / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D008297:Male; D013899:Thoracic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic
chemical_list: D018951:Antigens, CD20; C530104:CCND1 protein, human; D018956:CD5 Antigens; D019938:Cyclin D1