title: [Risk factor treatment and control in relation to coronary disease risk in the Spanish population of the DARIOS Study].
abstract: OBJECTIVE
  The treatment and control of cardiovascular risk factors both play key roles in primary prevention. The aim of the present study is to analyze the proportion of primary prevention patients aged 35-74 years being treated and controlled in relation to their level of coronary risk.
  
  
  METHODS
  Pooled analysis with individual data from 11 studies conducted in the first decade of the 21st century. We used standardized questionnaires and blood pressure measures, glycohemoglobin and lipid profiles. We defined optimal risk factor control as blood pressure < 140/90 mm Hg and glycohemoglobin <7%. In hypercholesterolemia, we applied both the European Societies and Health Prevention and Promotion Activities Programme criteria.
  
  
  RESULTS
  We enrolled 27 903 participants (54% women). Drug treatments were being administered to 68% of men and 73% of women with a history of hypertension (P<.001), 66% and 69% respectively, of patients with diabetes (P=.03), and 39% and 42% respectively, of those with hypercholesterolemia (P<.001). Control was good in 34% of men and 42% of women with hypertension (P<.001); 65% and 63% respectively, of those with diabetes (P=.626); 2% and 3% respectively, of patients with hypercholesterolemia according to European Societies criteria (P=.092) and 46% and 52% respectively, of those with hypercholesterolemia according to Health Prevention and Promotion Activities Programme criteria (P<.001). The proportion of uncontrolled participants increased with coronary risk (P<.001), except in men with diabetes. Lipid-lowering treatments were more often administered to women with ≥ 10% coronary risk than to men (59% vs. 50%, P = 0,024). [corrected]
  
  
  CONCLUSIONS
  The proportion of well-controlled participants was 65% at best. The European Societies criteria for hypercholesterolemia were vaguely reached. Lipid-lowering treatment is not prioritized in patients at high coronary risk.
authors.affiliation: Grupo de Epidemiología y Genética Cardiovascular, Programa de Investigación en Procesos Inflamatorios y Cardiovasculares, IMIM, Barcelona, España; Centro de Salud La Marina, IDIAP Jordi Gol, Institut Català de la Salut, Barcelona, España.
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Baena-Díez
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Félix
authors.forename: María
authors.initials: M
authors.lastname: Grau
authors.forename: Antonio
authors.initials: A
authors.lastname: Cabrera de León
authors.forename: Hector
authors.initials: H
authors.lastname: Sanz
authors.forename: Manuel
authors.initials: M
authors.lastname: Leal
authors.forename: Roberto
authors.initials: R
authors.lastname: Elosua
authors.forename: María Del Cristo
authors.initials: Mdel C
authors.lastname: Rodríguez-Pérez
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Guembe
authors.forename: Pere
authors.initials: P
authors.lastname: Torán
authors.forename: Tomás
authors.initials: T
authors.lastname: Vega-Alonso
authors.forename: Honorato
authors.initials: H
authors.lastname: Ortiz
authors.forename: José Fernando
authors.initials: JF
authors.lastname: Pérez-Castán
authors.forename: Guillermo
authors.initials: G
authors.lastname: Frontera-Juan
authors.forename: José
authors.initials: J
authors.lastname: Lapetra
authors.forename: María José
authors.initials: MJ
authors.lastname: Tormo
authors.forename: Antonio
authors.initials: A
authors.lastname: Segura
authors.forename: Daniel
authors.initials: D
authors.lastname: Fernández-Bergés
authors.forename: Jaume
authors.initials: J
authors.lastname: Marrugat
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003327:Coronary Disease / Q000453:epidemiology* / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000628:therapy; D006973:Hypertension / Q000453:epidemiology / Q000628:therapy; D008019:Life Style; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011322:Primary Prevention; D012307:Risk Factors; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D008055:Lipids