title: A novel case of a raised testosterone and LH in a young man.
abstract: A 19 year old male attended his GP with a history of "fluid retention", lack of libido and erectile dysfunction. He was found to have a high serum testosterone, and a raised luteinising hormone. After further investigations, the patient admitted to taking a supplement called ActivaTe Xtreme, obtained from an internet source, to address his low libido. ActivaTe Xtreme contains active ingredients which increase serum testosterone levels by several independent mechanisms that are not associated with luteinising hormone suppression. Urine analyses for synthetic anabolic steroids were negative, and urinary testosterone, epitestosterone and other androgens were normal. This biochemical pattern is not the same as that seen with anabolic steroids (i.e. raised testosterone, suppressed luteinising hormone and abnormal urine steroid profile). The issue of self medication with performance enhancing compounds needs to be carefully considered in order to avoid expensive and invasive investigations, missing an underlying pathology or misdiagnosing a patient. This case also raises the spectre of yet another "performance enhancing" product that may cause difficulty for those trying to ensure that sport remains on a "hormonally" equal basis.
authors.affiliation: Clinical Chemistry, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. Tim.McDonald@rdeft.nhs.uk
authors.forename: Tim J
authors.initials: TJ
authors.lastname: McDonald
authors.forename: Mandy H
authors.initials: MH
authors.lastname: Perry
authors.forename: Angus G
authors.initials: AG
authors.lastname: Jones
authors.forename: Mollie
authors.initials: M
authors.lastname: Donohoe
authors.forename: Maurice B
authors.initials: MB
authors.lastname: Salzmann
authors.forename: John
authors.initials: J
authors.lastname: O'Connor
mesh_terms: D000328:Adult; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood*; D016055:Urinary Retention / Q000097:blood*; D055815:Young Adult
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone