title: Feasible Synthesis of Antagonist of GPR40 by Constructing 2-Thiouracil Ring viaAcid Mediated Cyclization.
abstract: GW1100 is an antagonist of GPR40 identified by high throughput screening recently. The synthesis of GW1100 has been developed. The key step involves cyclization of the 2-thiouracil heterocycle under acidic condition at room temperature.
authors.affiliation: Department of Bioengineering, Bourns College of Engineering, University of California-Riverside, Riverside, CA 92507, USA.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yang
authors.initials: Y
authors.lastname: Song
authors.forename: Xiulin
authors.initials: X
authors.lastname: Shen
authors.forename: Jiayu
authors.initials: J
authors.lastname: Liao