title: Effects of BDE-85 on the oxidative status and nerve conduction in rodents.
abstract: BDE-85 is a congener of a class of flame-retardant compounds called polybrominated diphenyl ethers (PBDEs). Although there are some studies on other congeners of PBDEs, there are none on the toxicity potential of this penta-BDE member. This study, therefore, reports the oxidative status and sciatic nerve conduction properties following BDE-85 treatment in rodents. The oxidative stress markers, lipid hydroperoxides, and the activities of antioxidant enzymes, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and catalase, in the exposed mice liver and brain tissues showed tissue-specific alterations following intraperitoneal injection of 0.25 mg/kg body weight of BDE-85 for 4 days. The results indicate a significant disruption in the oxidant/antioxidant equilibrium and setting in of oxidative stress. Isolated sciatic nerves of rats exposed to 5 µg/mL or 20 µg/mL of BDE-85 showed a significant reduction in nerve conduction velocity and compound action potential amplitudes, indicating physiological damage to the sciatic nerves.
authors.affiliation: Biology Department, Gannon University, Erie, PA 16541, USA. vagula001@gannon.edu
authors.forename: Mary C
authors.initials: MC
authors.lastname: Vagula
authors.forename: Nathan
authors.initials: N
authors.lastname: Kubeldis
authors.forename: Charles F
authors.initials: CF
authors.lastname: Nelatury
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers; D001921:Brain / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D005411:Flame Retardants / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D055768:Halogenated Diphenyl Ethers / Q000633:toxicity*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D009431:Neural Conduction / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; C086401:pentabromodiphenyl ether; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase