title: Evaluation of the analgesic activity of ethyl acetate, methanol and aqueous extracts of Pleurotus eous mushroom.
abstract: OBJECTIVE
  To evaluate the analgesic activity of the ethyl acetate, methanol and aqueous extracts of Pleurotus eous (P. eous) mushroom.
  
  
  METHODS
  The dried fruiting bodies were extracted with ethyl acetate, methanol and water. The analgesic effect of extracts of P. eous were investigated at doses 250,500 and 1,000 mg/kg body weight, using acetic-acid induced writhing, hot-plate, tail immersion and tail-clip tests.
  
  
  RESULTS
  P. eous extracts produced significant reduction in number of writhes induced by intraperitoneal injection of acetic-acid (P<0.05). Moreover, in hot-plate and tail immersion test, all the three extracts significantly raised the pain threshold at different time of observation (0-60 min) in comparison with control (P<0.05). In tail-clip test the extracts also caused a significant inhibition of pain at both the doses used (P<0.05).
  
  
  CONCLUSIONS
  The results of present study suggest that extracts of P. eous possess potent analgesic property and could serve as a base for future drugs.
authors.affiliation: Pharmaceutical Chemistry Division, School of Advanced Sciences, VIT University, Vellore-632 014, Tamil Nadu, India.
authors.forename: S R
authors.initials: SR
authors.lastname: Suseem
authors.forename: A
authors.initials: A
authors.lastname: Mary Saral
authors.forename: P
authors.initials: P
authors.lastname: Neelakanda Reddy
authors.forename: Gregory
authors.initials: G
authors.lastname: Marslin
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D005260:Female; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D020076:Pleurotus / Q000737:chemistry*; D013623:Tail / Q000293:injuries
chemical_list: D000700:Analgesics