title: Salmonella enterica Serotype Typhi with nonclassical quinolone resistance phenotype.
abstract: We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.
authors.affiliation: Institut Pasteur, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Accou-Demartin
authors.forename: Valérie
authors.initials: V
authors.lastname: Gaborieau
authors.forename: Yajun
authors.initials: Y
authors.lastname: Song
authors.forename: Philippe
authors.initials: P
authors.lastname: Roumagnac
authors.forename: Bruno
authors.initials: B
authors.lastname: Marchou
authors.forename: Mark
authors.initials: M
authors.lastname: Achtman
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Weill
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D005798:Genes, Bacterial / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D015363:Quinolones / Q000494:pharmacology*; D012485:Salmonella typhi / Q000187:drug effects* / Q000235:genetics; D014435:Typhoid Fever / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones