title: Rescue therapy with local intra-arterial urokinase after poor clinical response with intravenous recombinant tissue plasminogen activator in acute ischaemic stroke.
abstract: We report a case of combined intravenous and intra-arterial thrombolysis in a patient presenting with acute ischaemic stroke. Progression to intra-arterial thrombolysis in patients who fail to show clinical improvement within 6 h of symptom onset might be a safe treatment option at centres with access to stroke specialist and endovascular services. The purpose of this report is to demonstrate the efficacy and potential benefits of this rescue therapy.
authors.affiliation: Department of Medicine, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia. leeleonghui@gmail.com
authors.forename: L H
authors.initials: LH
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Chryssidis
authors.forename: J
authors.initials: J
authors.lastname: Jannes
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis* / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D020521:Stroke / Q000175:diagnosis* / Q000188:drug therapy* / Q000201:enzymology; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator