title: Neuropective constituents from the rhizomes of Abacopteris penangiana.
abstract: Two neuropective compounds were isolated from the rhizomes of Abacopteris penangiana, one was a new flavone and the other was a flavanone. Both compounds were firstly separated from natural plant. The isolation work was guided by the antioxidant activity. Both the compounds showed a significant antioxidant activity in vitro and a protective effect on dopamine-induced neurotoxicity in PC12 cells.
authors.affiliation: Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation of Hubei Province, Tongji Medical Center, College of Pharmacy, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Han
authors.initials: H
authors.lastname: Wei
authors.forename: Guang-Hua
authors.initials: GH
authors.lastname: Wu
authors.forename: Yong-Fang
authors.initials: YF
authors.lastname: Lei
authors.forename: Chao-Mei
authors.initials: CM
authors.lastname: Xiong
authors.forename: Jin-Lan
authors.initials: JL
authors.lastname: Ruan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D029624:Ferns / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016716:PC12 Cells; D051381:Rats; D027343:Rhizome / Q000737:chemistry
chemical_list: C560950:(2S)-5,2',5'-trihydroxy-7-methoxyflavanone; C560949:5,2',5'-trihydroxy-7-methoxyflavone; D000975:Antioxidants; D044950:Flavanones; D047309:Flavones; D018696:Neuroprotective Agents; D004298:Dopamine