title: [Cardiovascular disorders and rheumatic disease].
abstract: Cardiovascular disease is a common and under-recognized problem in patients with systemic rheumatic conditions. Patients may present with disease associated heart involvement at the time of diagnosis or later in the course of the illness. The manifestations vary by disease, and all structures in the heart can be affected and may result in significant morbidity and mortality. Manifestations of cardiac disease in these patients range from subclinical to severe and may require aggressive immunosuppressive therapy. Early recognition is important for prompt institution of appropriate therapy. Treatment of disease associated cardiac involvement is based on severity of disease with more severe manifestations often requiring a combination of corticosteroid and cytotoxic agent. Premature atherosclerosis has been increasingly recognized in patients with systemic lupus erythematosus and rheumatoid arthritis and may result in premature coronary death when compared to the general population. Aggressive control of systemic inflammation in these diseases may result in a reduction in the risk of ischemic heart disease. Although aggressive treatment of the primary rheumatic disease has been associated with an improvement in mortality rates, specific guidelines for prevention of ischemic heart disease in this group of patients have not been formulated and recommendations at this time include aggressive control and monitoring of traditional risk factors.
authors.affiliation: Center for Vasculitis Care and Research, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, Ohio, USA. villaa@ccf.org
authors.forename: Alexandra
authors.initials: A
authors.lastname: Villa-Forte
authors.forename: Brian F
authors.initials: BF
authors.lastname: Mandell
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D012216:Rheumatic Diseases / Q000150:complications*; D012306:Risk; D012595:Scleroderma, Systemic / Q000150:complications; D013167:Spondylitis, Ankylosing / Q000150:complications; D014657:Vasculitis / Q000150:complications