title: Impact of model parameters on Monte Carlo simulations of backscattering Mueller matrix images of colon tissue.
abstract: Polarimetric imaging is emerging as a viable technique for tumor detection and staging. As a preliminary step towards a thorough understanding of the observed contrasts, we present a set of numerical Monte Carlo simulations of the polarimetric response of multilayer structures representing colon samples in the backscattering geometry. In a first instance, a typical colon sample was modeled as one or two scattering "slabs" with monodisperse non absorbing scatterers representing the most superficial tissue layers (the mucosa and submucosa), above a totally depolarizing Lambertian lumping the contributions of the deeper layers (muscularis and pericolic tissue). The model parameters were the number of layers, their thicknesses and morphology, the sizes and concentrations of the scatterers, the optical index contrast between the scatterers and the surrounding medium, and the Lambertian albedo. With quite similar results for single and double layer structures, this model does not reproduce the experimentally observed stability of the relative magnitudes of the depolarizing powers for incident linear and circular polarizations. This issue was solved by considering bimodal populations including large and small scatterers in a single layer above the Lambertian, a result which shows the importance of taking into account the various types of scatterers (nuclei, collagen fibers and organelles) in the same model.
authors.forename: Maria-Rosaria
authors.initials: MR
authors.lastname: Antonelli
authors.forename: Angelo
authors.initials: A
authors.lastname: Pierangelo
authors.forename: Tatiana
authors.initials: T
authors.lastname: Novikova
authors.forename: Pierre
authors.initials: P
authors.lastname: Validire
authors.forename: Abdelali
authors.initials: A
authors.lastname: Benali
authors.forename: Brice
authors.initials: B
authors.lastname: Gayet
authors.forename: Antonello
authors.initials: A
authors.lastname: De Martino