title: Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil.
abstract: We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymerase chain reaction and analyzed on a 2% agarose gel stained with ethidium bromide. The frequency of polymorphic genotypes (A1/A2 and A2/A2) was significantly higher in patients with endometriosis (33%) than in the control group (16%). We conclude that there is a significant correlation between PROGINS polymorphism and endometriosis.
authors.affiliation: Núcleo de Pesquisas Replicon, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil. iasmimribeirodacosta@gmail.com
authors.forename: I R
authors.initials: IR
authors.lastname: Costa
authors.forename: R C P C
authors.initials: RC
authors.lastname: Silva
authors.forename: A B
authors.initials: AB
authors.lastname: Frare
authors.forename: C T X
authors.initials: CT
authors.lastname: Silva
authors.forename: B M
authors.initials: BM
authors.lastname: Bordin
authors.forename: S R
authors.initials: SR
authors.lastname: Souza
authors.forename: C L
authors.initials: CL
authors.lastname: Ribeiro Júnior
authors.forename: K K V O
authors.initials: KK
authors.lastname: Moura
mesh_terms: D000328:Adult; D020087:Alu Elements / Q000235:genetics; D001938:Brazil; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011980:Receptors, Progesterone / Q000097:blood / Q000235:genetics*; D012307:Risk Factors
chemical_list: D011980:Receptors, Progesterone