title: Synthesis, kinetic evaluation and cell-based analysis of C-alkylated isofagomines as chaperones of β-glucocerebrosidase.
authors.affiliation: Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T 1Z1, Canada.
authors.forename: Tara
authors.initials: T
authors.lastname: Hill
authors.forename: Michael B
authors.initials: MB
authors.lastname: Tropak
authors.forename: Don
authors.initials: D
authors.lastname: Mahuran
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Withers
mesh_terms: D000478:Alkylation; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects* / Q000201:enzymology*; D005962:Glucosylceramidase / Q000037:antagonists & inhibitors*; D006801:Humans; D050112:Imino Pyranoses / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics
chemical_list: D004791:Enzyme Inhibitors; D050112:Imino Pyranoses; C098432:isofagomine; D005962:Glucosylceramidase