title: Primary meningeal rhabdomyosarcoma.
abstract: Primary meningeal rhabdomyosarcoma is a rare primary brain malignancy, with scant case reports. While most reports of primary intracranial rhabdomyosarcoma occur in pediatric patients, a handful of cases in adult patients have been reported in the medical literature. We report the case of a 44-year-old male who developed primary meningeal rhabdomyosarcoma. After developing episodes of right lower extremity weakness, word finding difficulty, and headaches, a brain magnetic resonance imaging (MRI) demonstrated a vertex lesion with radiographic appearance of a meningeal-derived tumor. Subtotal surgical resection was performed due to sagittal sinus invasion and initial pathology was interpreted as an anaplastic meningioma. Re-review of pathology demonstrated rhabdomyosarcoma negative for alveolar translocation t(2;13). Staging studies revealed no evidence of disseminated disease. He was treated with stereotactic radiotherapy with concurrent temozolamide to be followed by vincristine, actinomycin-D, and cyclophosphamide (VAC) systemic therapy.
authors.affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Manisha
authors.initials: M
authors.lastname: Palta
authors.forename: Richard F
authors.initials: RF
authors.lastname: Riedel
authors.forename: James J
authors.initials: JJ
authors.lastname: Vredenburgh
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Cummings
authors.forename: Scott
authors.initials: S
authors.lastname: Green
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chang
authors.forename: John P
authors.initials: JP
authors.lastname: Kirkpatrick