title: Evolution of pulmonary function after treatment with goserelin in patients with lymphangioleiomyomatosis.
abstract: In the atypical smooth muscle cells that are characteristic of lymphangioleiomyomatosis (LAM), there are estrogen and progesterone receptors. Therefore, anti-hormonal therapy, despite having produced controversial results, can be considered a treatment option. The objective of this retrospective study was to evaluate hormonal and spirometric data for nine women with LAM after one year of treatment with goserelin. The mean increase in FEV1 and FVC was 80 mL and 130 mL, respectively. There was effective blockage of the hormonal axis. It is still not possible to exclude a potential beneficial effect of the use of gonadotropin-releasing hormone analogues in LAM patients, which underscores the need for randomized trials.
authors.affiliation: Department of Pulmonology, Instituto do Coração - InCor, Heart Institute - and in the Department of Urology, University of São Paulo School of Medicine Hospital das Clínicas, São Paulo, Brazil. bruno.guedes2@terra.com.br
authors.forename: Bruno Guedes
authors.initials: BG
authors.lastname: Baldi
authors.forename: Pedro
authors.initials: P
authors.lastname: Medeiros Junior
authors.forename: Suzana Pinheiro
authors.initials: SP
authors.lastname: Pimenta
authors.forename: Roberto Iglesias
authors.initials: RI
authors.lastname: Lopes
authors.forename: Ronaldo Adib
authors.initials: RA
authors.lastname: Kairalla
authors.forename: Carlos Roberto Ribeiro
authors.initials: CR
authors.lastname: Carvalho
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D005260:Female; D017273:Goserelin / Q000627:therapeutic use*; D006728:Hormones / Q000378:metabolism; D006801:Humans; D018192:Lymphangioleiomyomatosis / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014797:Vital Capacity / Q000187:drug effects*; D055815:Young Adult
chemical_list: D018931:Antineoplastic Agents, Hormonal; D006728:Hormones; D017273:Goserelin