title: Cattle and chemokines: evidence for species-specific evolution of the bovine chemokine system.
abstract: The chemokine system comprises a family of small chemoattractant molecules that have roles in both the healthy and diseased organism. Chemokines act by binding specific receptors on the target cell surface and inducing chemotaxis. The human chemokine system is well characterized, with approximately fifty chemokines identified that fall into four families. The chemokines and their receptors are promiscuous in that one chemokine can often bind several receptors, and vice versa. Study of the bovine chemokine system has been restricted to date to a handful of chemokines, and the identification of bovine chemokines is largely based on the closest human homologue. This method of identification is prone to error and may result in the misassumption of function of a particular chemokine. Here, we review current knowledge of bovine chemokines and reassess the bovine chemokine system based on phylogenetic and syntenic approaches. The bovine chemokine system, for the most part, shows high similarity to the chemokine system of other mammals such as humans; however, differences have been identified. Cattle possess fewer chemokines than humans, yet also possess chemokines that have no obvious homologue in the human system. These 'missing' and 'novel' chemokines may represent functional differences between the bovine and human chemokine systems that may affect the way in which these species are able to respond to specific pathogen repertoires.
authors.affiliation: Institute for Animal Health, Compton, Newbury, Berkshire, UK.
authors.forename: S
authors.initials: S
authors.lastname: Widdison
authors.forename: T J
authors.initials: TJ
authors.lastname: Coffey
mesh_terms: D000818:Animals; D002417:Cattle; D018925:Chemokines / Q000145:classification* / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D019143:Evolution, Molecular; D006801:Humans; D005810:Multigene Family / Q000235:genetics*; D010802:Phylogeny; D013045:Species Specificity; D026801:Synteny / Q000235:genetics
chemical_list: D018925:Chemokines