title: No association of type 2 diabetes risk variants and prostate cancer risk: the multiethnic cohort and PAGE.
abstract: BACKGROUND
  Epidemiologic studies have found evidence of an inverse association between diabetes status and prostate cancer risk. We explored the hypothesis that common genetic variation may explain, in part, the inverse association between diabetes and prostate cancer.
  
  
  METHODS
  We tested 17 diabetes risk variants for association with prostate cancer risk in a prostate cancer case-control study of 2,746 cases and 3,317 controls from five racial/ethnic groups in the Multiethnic Cohort (MEC) study.
  
  
  RESULTS
  After adjustment for multiple testing, none of the alleles were statistically significantly associated with prostate cancer risk. Aggregate scores that sum the risk alleles were also not significantly associated with risk.
  
  
  CONCLUSIONS
  We did not find evidence of association of this set of diabetes risk alleles with prostate cancer.
  
  
  CONCLUSIONS
  Resequencing and fine-mapping of the loci for diabetes and prostate cancer that were identified by genome-wide association studies are necessary to understand any genetic contribution for the inverse association between these common diseases.
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Harlyne Norris Research Tower, 1450 Biggy Street, Room 1504, Los Angeles, CA 90033, USA. kwaters@usc.edu
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Waters
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.forename: Kristine R
authors.initials: KR
authors.lastname: Monroe
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Stram
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.forename: Loïc
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
mesh_terms: D000368:Aged; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000208:ethnology* / Q000235:genetics; D014644:Genetic Variation; D005838:Genotype; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000208:ethnology* / Q000235:genetics; D012307:Risk Factors; D018426:SEER Program