title: The distribution of human leukocyte antigen-A, -B, and -DRB1 alleles and haplotypes based on high-resolution genotyping of 167 families from Jiangsu Province, China.
abstract: We investigated the human leukocyte antigen (HLA)-A, -B, and -DRB1 allele frequencies, the A-B-DRB1, A-B, B-DRB1, and A-DRB1 haplotype frequencies, and the characteristics of linkage disequilibrium between 2 loci in high resolution based on 167 unrelated families from Jiangsu Province, China. A total of 26 alleles at the A locus, 55 alleles at the B locus, and 34 alleles at the DRB1 locus were reported in this study. The top 5 most frequent HLA alleles at the HLA-A, -B, and -DRB1 loci, respectively, were A*11:01, A*24:02, A*02:01, A*33:03, A*30:01; B*13:02, B*40:01 B*46:01, B*58:01, B*54:01; DRB1*09:01, DRB1*07:01, DRB1*12:02, DRB1*15:01, and DRB1*08:03. Several haplotypes with high frequencies were deduced in this study. The top 3 most common A-B-DRB1 haplotypes observed were A*30:01-B*13:02-DRB1*07:01, A*33:03-B*58:01-DRB1*03:01, and A*02:07-B*46:01-DRB1*09:01. The top 3 most common A-B haplotypes were A*30:01-B*13:02, A*33:03-B*58:01, and A*02:07-B*46:01. The top 4 most common A-DRB1 haplotypes were A*30:01-DRB1*07:01, A*33:03-DRB1*13:02, A*24:02-DRB1*09:01, and A*33:03-DRB1*03:01. Finally, the top 3 most common B-DRB1 haplotypes were B*13:02-DRB1*07:01, B*46:01-DRB1*09:01, and B*58:01-DRB1*03:01. From the linkage disequilibrium calculation, the most prominent associations were A*30:01-B*13:02, B*13:02-DRB1*07:01, and A*01:03-DRB1*01:02. These allele and haplotype frequencies could be useful for finding the best matched donors for patients in the China Marrow Donor Program Jiangsu Branch.
authors.affiliation: HLA Laboratory, First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Qin-Qin
authors.initials: QQ
authors.lastname: Pan
authors.forename: Su
authors.initials: S
authors.lastname: Fan
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Wang
authors.forename: Meng
authors.initials: M
authors.lastname: Pan
authors.forename: Xing
authors.initials: X
authors.lastname: Zhao
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Zhou
authors.forename: Cheng-Ya
authors.initials: CY
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D005828:Genetics, Population; D005838:Genotype; D015234:HLA-A Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D015235:HLA-B Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D059811:HLA-DRB1 Chains / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007962:Leukocytes / Q000737:chemistry* / Q000166:cytology / Q000276:immunology; D015810:Linkage Disequilibrium; D008297:Male; D010802:Phylogeny
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059811:HLA-DRB1 Chains