title: The role of NDR1 in pathogen perception and plant defense signaling.
abstract: The biochemical and cellular function of NDR1 in plant immunity and defense signaling has long remained elusive. Herein, we describe a novel role for NDR1 in both pathogen perception and plant defense signaling, elucidated by exploring a broader, physiological role for NDR1 in general stress responses and cell wall adhesion. Based on our predictive homology modeling, coupled with a structure-function approach, we found that NDR1 shares a striking similarity to mammalian integrins, well-characterized for their role in mediating the interaction between the extracellular matrix and stress signaling. ndr1-1 mutant plants exhibit higher electrolyte leakage following pathogen infection, compared to wild type Col-0. In addition, we observed an altered plasmolysis phenotype, supporting a role for NDR1 in maintaining cell wall-plasma membrane adhesions through mediating fluid loss under stress.
authors.affiliation: Department of Energy, Plant Research Laboratory, Michigan State University, East Lansing, MI, USA.
authors.forename: Caleb
authors.initials: C
authors.lastname: Knepper
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Savory
authors.forename: Brad
authors.initials: B
authors.lastname: Day
mesh_terms: D029681:Arabidopsis Proteins / Q000378:metabolism*; D016023:Integrins / Q000378:metabolism; D008958:Models, Molecular; D010935:Plant Diseases / Q000276:immunology* / Q000382:microbiology; D057865:Plant Immunity; D018521:Plant Physiological Phenomena; D010944:Plants / Q000276:immunology*; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D016023:Integrins; C109369:NDR1 protein, Arabidopsis; D014157:Transcription Factors