title: Surface modification of PDMS by surface-initiated atom transfer radical polymerization of water-soluble dendronized PEG methacrylate.
abstract: The current paper reports the synthesis of a highly hydrophilic, antifouling dendronized poly(3,4,5-tris(2-(2-(2-hydroxylethoxy)ethoxy)ethoxy)benzyl methacrylate) (PolyPEG) brush using surface initiated atom transfer radical polymerization (SI-ATRP) on PDMS substrates. The PDMS substrates were first oxidized in H(2)SO(4)/H(2)O(2) solution to transform the Si-CH(3) groups on their surfaces into Si-OH groups. Subsequently, a surface initiator for ATRP was immobilized onto the PDMS surface, and PolyPEG was finally grafted onto the PDMS surface via copper-mediated ATRP. Various characterization techniques, including contact angle measurements, attenuated total reflection infrared spectroscopy, and X-ray photoelectron spectroscopy, were used to ascertain the successful grafting of the PolyPEG brush onto the PDMS surface. Furthermore, the wettability and stability of the PDMS-PolyPEG surface were examined by contact angle measurements. Anti-adhesion properties were investigated via protein adsorption, as well as bacterial and cell adhesion studies. The results suggest that the PDMS-PolyPEG surface exhibited durable wettability and stability, as well as significantly anti-adhesion properties, compared with native PDMS surfaces. Additionally, our results present possible uses for the PDMS-PolyPEG surface as adhesion barriers and anti-fouling or functional surfaces in biomedical applications.
authors.affiliation: Colleges of Science and Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, PR China.
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jianchun
authors.initials: J
authors.lastname: Wang
authors.forename: Qin
authors.initials: Q
authors.lastname: Tu
authors.forename: Nan
authors.initials: N
authors.lastname: Nie
authors.forename: Jun
authors.initials: J
authors.lastname: Sha
authors.forename: Wenming
authors.initials: W
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jinyi
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D004129:Dimethylpolysiloxanes / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D046210:Microfluidic Analytical Techniques; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D056951:Photoelectron Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties; D017155:Wettability
chemical_list: D004129:Dimethylpolysiloxanes; D011108:Polymers; D011092:Polyethylene Glycols; C013830:baysilon