title: Post-exposure prophylaxis for H1N1 with oseltamivir in renal allograft recipient--safe and effective without any immunosuppresive drug interaction.
abstract: Kidney transplant recipients are at a high risk for H1N1 infection associated complications during the current pandemic. Prevention of infection by immunization, together with early recognition and prompt antiviral treatment are critical. Post-exposure prophylaxis of H1N1 with oseltamivir was safe, effective and well tolerated to prevent H1N1 influenza A virus infection in newly transplanted renal allograft recipient receiving triple immunosuppression without any interaction with tacrolimus level. Oseltamivir was effective for post-exposure prophylaxis of H1N1 in close contact.
authors.affiliation: Department of Nephrology and Clinical Transplantation, Dr H L Trivedi Institute of Transplantation Sciences (ITS) Ahmedabad 380016, Gujarat, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Kute
authors.forename: K R
authors.initials: KR
authors.lastname: Goplani
authors.forename: S M
authors.initials: SM
authors.lastname: Godara
authors.forename: P R
authors.initials: PR
authors.lastname: Shah
authors.forename: A V
authors.initials: AV
authors.lastname: Vanikar
authors.forename: H L
authors.initials: HL
authors.lastname: Trivedii
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004347:Drug Interactions; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000302:isolation & purification; D007251:Influenza, Human / Q000517:prevention & control* / Q000635:transmission; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy; D011247:Pregnancy; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D053139:Oseltamivir