title: Coordination Driven Self-Assembly and Anticancer Activity of Molecular Rectangles Containing Octahedral Ruthenium Metal Centers.
abstract: The synthesis of new 2+2 metalla-rectangles via coordination driven self-assembly of octahedral Ru(II) based acceptors and amide donors is described. To evaluate their in vitro cytotoxic properties, preliminary biological assays were carried out for various human cancer cell lines, and our results show that the cytotoxicity level of 3 is comparable or even greater in the cases of SK-hep-1 and HCT-15 than that of the reference drug cisplatin.
authors.affiliation: Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea.
authors.forename: Vaishali
authors.initials: V
authors.lastname: Vajpayee
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Song
authors.forename: Yoon Jung
authors.initials: YJ
authors.lastname: Yang
authors.forename: Se Chan
authors.initials: SC
authors.lastname: Kang
authors.forename: Hyunuk
authors.initials: H
authors.lastname: Kim
authors.forename: In Su
authors.initials: IS
authors.lastname: Kim
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Stang
authors.forename: Ki-Whan
authors.initials: KW
authors.lastname: Chi