title: Evaluation of genotoxic and oxidative effects in workers exposed to jet propulsion fuel.
abstract: OBJECTIVE
  Jet fuel is a common occupational exposure risk among military and civilian populations. The purpose of this study was to evaluate genotoxic and oxidative effects in workers occupational exposure to jet propulsion fuel (JP-8).
  
  
  METHODS
  In this study, sister-chromatid exchange (SCE), high frequency of SCE cells (HFCs), and micronuclei (MN) were determined for 43 workers exposed to JP-8 and 38 control subjects. We measured the antioxidant enzyme activities including that of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT). The levels of thiobarbituric acid-reactive substances (TBARS) were also studied. Urinary 1- and 2-naphthol excretion was used as a biomarker of occupational exposure to JP-8.
  
  
  RESULTS
  The results obtained from cytogenetic analysis show a statistically significant increase in frequency of SCE in the exposed workers when compared to controls (P < 0.05). Interestingly, the mean value of the frequency (%o) of MN and HFCs for workers and controls did not show any statistical differences (P > 0.05). Oxidative stress parameters were not statistically different between exposed and control groups except for TBARS levels.
  
  
  CONCLUSIONS
  Urinary 1-and 2-naphthol levels of exposed workers were found to be significantly higher than those of control subjects. Occupational exposure to JP-8 resulted in no significant genotoxic and oxidative effects, while smoking is the principal confounding factor for the some parameters. To understand the genotoxic and oxidative effects of JP-8 exposure, further studies should be planned to find out whether human populations may be at increased risk for cancer because of the exposures related to occupation and lifestyle.
authors.affiliation: Department of Toxicology, Gülhane Military Medical Academy, Etlik, 06018, Ankara, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Erdem
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sayal
authors.forename: Ayşe
authors.initials: A
authors.lastname: Eken
authors.forename: Cemal
authors.initials: C
authors.lastname: Akay
authors.forename: Ahmet
authors.initials: A
authors.lastname: Aydın
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism / Q000652:urine; D016022:Case-Control Studies; D004249:DNA Damage; D006801:Humans; D006838:Hydrocarbons / Q000009:adverse effects*; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D015162:Micronucleus Tests; D009284:Naphthols / Q000652:urine; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D018384:Oxidative Stress; D012854:Sister Chromatid Exchange; D012907:Smoking; D011795:Surveys and Questionnaires; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D006838:Hydrocarbons; D009284:Naphthols; D017392:Thiobarbituric Acid Reactive Substances; C029350:1-naphthol; C029662:JP5 jet fuel; C028405:2-naphthol