title: Factor IXa as a target for pharmacologic inhibition in acute coronary syndrome.
abstract: Anticoagulant therapy, combined with platelet-directed inhibitors, represents a standard-of-care in the management of patients with acute coronary syndrome, particularly those who require percutaneous coronary interventions. While a vast clinical experience, coupled with large clinical trials have collectively provided guidance, an optimal anticoagulant drug and applied strategy, defined as one that reduces thrombotic and hemorrhagic events consistently, with minimal off-target effects and active control of systemic anticoagulation according to patient and clinical-setting specific need, remains at large. An advancing knowledge of coagulation, hemostasis, and thrombosis suggests that factor IXa, a protease that governs thrombin generation in common thrombotic disorders may represent a prime target for pharmacologic inhibition.
authors.affiliation: Department of Medicine, Divisions of Cardiology and Hematology, Duke University Medical Center, Duke University School of Medicine and Duke Clinical Research Institute, Advanced Biomarkers Program, Durham, NC, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Roser-Jones
authors.forename: Mark
authors.initials: M
authors.lastname: Chan
authors.forename: Emily L
authors.initials: EL
authors.lastname: Howard
authors.forename: Kristian C D
authors.initials: KC
authors.lastname: Becker
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Rusconi
authors.forename: Richard C
authors.initials: RC
authors.lastname: Becker
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000188:drug therapy*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D052157:Aptamers, Nucleotide / Q000627:therapeutic use; D001665:Binding Sites; D001792:Blood Platelets / Q000502:physiology; D015949:Factor IXa / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002836:Hemophilia B / Q000097:blood; D006801:Humans; D011485:Protein Binding; D013927:Thrombosis / Q000209:etiology
chemical_list: D000911:Antibodies, Monoclonal; D052157:Aptamers, Nucleotide; D015949:Factor IXa