title: Ethyl malonate amides: a diketo acid offspring fragment for HIV integrase inhibition.
abstract: While searching for new HIV integrase inhibitors we discovered that some ethyl malonate amides (EMA) are active against this enzyme. Surprisingly, the main function can only very rarely be found among the reported drug candidates. We synthesised a series of compounds in order to establish and analyse the structure-activity relationship. The similarity to the important classes of HIV integrase inhibitors as well as the synthetic availability of the different targets including this pharmacophore makes EMA compounds an interesting object of investigations.
authors.affiliation: Institute of Chemistry, University of Silesia, PL-40006 Katowice, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Serafin
authors.forename: Pawel
authors.initials: P
authors.lastname: Mazur
authors.forename: Andrzej
authors.initials: A
authors.lastname: Bak
authors.forename: Elodie
authors.initials: E
authors.lastname: Laine
authors.forename: Luba
authors.initials: L
authors.lastname: Tchertanov
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mouscadet
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Polanski
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D057225:Data Mining; D015195:Drug Design; D019427:HIV Integrase / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D007651:Keto Acids / Q000138:chemical synthesis* / Q000737:chemistry; D008314:Malonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D058990:Molecular Targeted Therapy; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000998:Antiviral Agents; D002264:Carboxylic Acids; D019428:HIV Integrase Inhibitors; D007651:Keto Acids; D008314:Malonates; D011804:Quinolines; D019427:HIV Integrase