title: Possibility of myelodysplastic syndromes screening using a complete blood automated cell count.
abstract: Diagnosis of MDS has changed during the last years because of the 2008 WHO classification. Complete blood cell count (CBC) is a very important tool both for diagnosis of MDS. The aim of this study was to evaluate if it is possible to use the abnormal signals produced by dysplastic cells to produce a flag "dysplasia" able to identify the patients needing further hematological investigations. The proposed flag has been tested in a large group of patients to evaluate the sensibility and specificity. We create 5 patterns of MDS. Our study demonstrated that the flag "dysplasia" is specific and sensible for MDS.
authors.affiliation: Department of Clinical Pathology, AO Rummo, Benevento, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Rocco
authors.forename: Mariacaterina
authors.initials: M
authors.lastname: Maconi
authors.forename: Maria
authors.initials: M
authors.lastname: Gioia
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Silvestri
authors.forename: Donatella
authors.initials: D
authors.lastname: Tanca
authors.forename: Teodora
authors.initials: T
authors.lastname: Catalano
authors.forename: Daniela
authors.initials: D
authors.lastname: Avino
authors.forename: Anna
authors.initials: A
authors.lastname: Di Palma
authors.forename: Adele
authors.initials: A
authors.lastname: Rovetti
authors.forename: Paolo
authors.initials: P
authors.lastname: Danise
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057205:Automation, Laboratory / Q000379:methods; D001772:Blood Cell Count / Q000295:instrumentation / Q000379:methods / Q000592:standards; D055088:Early Detection of Cancer / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000175:diagnosis*; D012016:Reference Values; D012680:Sensitivity and Specificity