title: Primary leiomyoma of the trachea, bronchus, and pulmonary parenchyma--a single-institutional experience.
abstract: OBJECTIVE
  Primary leiomyoma of the respiratory tract is a rare disease. Based on our experience, we investigated its clinical characteristics and outcomes of treatment.
  
  
  METHODS
  Between 1997 and 2008, 16 patients in our institution (nine male, seven female) were found to have primary leiomyoma of the respiratory tract. The median patient age was 46.5 years (range 17-66 years). The tumor was located in the trachea in four patients, in the carina and main bronchus in four, in the bronchus intermedius in four, in the lobar or segmental bronchus in two, and in the lung parenchyma in two.
  
  
  RESULTS
  Tumor removal through bronchoscopic intervention using Nd-YAG (neodymium-yttrium-aluminum-garnet) laser cauterization was attempted in 11 patients; it failed in two with wide-based tumors. Surgical resection was performed in seven patients. Operative procedures included tracheal resection and end-to-end anastomosis (n=3), lobectomy (n=3), and bilobectomy (n=1). There were no in-hospital mortalities. During a median follow-up duration of 43.2 months, one patient who underwent bronchoscopic removal had recurrence, for which segmental resection of the trachea and main bronchus with carinal reconstruction was performed.
  
  
  CONCLUSIONS
  Bronchoscopic intervention can offer successful control of primary leiomyoma of the main airway stem; however, in cases of a wide-based tumor, bronchoscopic intervention can result in incomplete resection or recurrence. Surgical complete resection can yield satisfactory outcomes in patients with primary leiomyoma occurring in the respiratory tract.
authors.affiliation: Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Joon Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Mina
authors.initials: M
authors.lastname: Lee
authors.forename: Hong Kwan
authors.initials: HK
authors.lastname: Kim
authors.forename: Yong Soo
authors.initials: YS
authors.lastname: Choi
authors.forename: Kwhanmien
authors.initials: K
authors.lastname: Kim
authors.forename: Jhingook
authors.initials: J
authors.lastname: Kim
authors.forename: Hojoong
authors.initials: H
authors.lastname: Kim
authors.forename: Young Mog
authors.initials: YM
authors.lastname: Shim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D001984:Bronchial Neoplasms / Q000175:diagnosis / Q000601:surgery; D001999:Bronchoscopy / Q000379:methods; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use; D007889:Leiomyoma / Q000601:surgery*; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012142:Respiratory Tract Neoplasms / Q000175:diagnosis* / Q000601:surgery; D014134:Tracheal Neoplasms / Q000175:diagnosis / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult