title: Molecular and nanotechnologic approaches to etiologic diagnosis of infectious syndromes.
abstract: Infectious diseases are a major global public health problem. Multiple agents are now recognized to cause indistinguishable illnesses. The term 'syndrome' applies to such situations, for which early and rapid diagnosis of the infecting agent would enable prompt and appropriate therapy. Public health physicians would also get timely information on the specific etiology of the infectious syndrome, facilitating intervention at the community level in the face of outbreaks or epidemics. A variety of molecular techniques have been evaluated for rapid diagnosis of infectious syndromes. These techniques include real-time multiplex PCR, DNA microarray, loop-mediated isothermal amplification, and other similar assays. This review surveys such state-of-the-art technologies.
authors.affiliation: Division of Biomedical Research, Sri Narayani Hospital and Research Centre, Thirumalaikodi, Sripuram, Vellore, Tamil Nadu, India. sathish3107@gmail.com
authors.forename: Sathish
authors.initials: S
authors.lastname: Sankar
authors.forename: Mageshbabu
authors.initials: M
authors.lastname: Ramamurthy
authors.forename: Balaji
authors.initials: B
authors.lastname: Nandagopal
authors.forename: Padma
authors.initials: P
authors.lastname: Srikanth
authors.forename: Ganesh
authors.initials: G
authors.lastname: Venkatraman
authors.forename: Gopalan
authors.initials: G
authors.lastname: Sridharan
mesh_terms: D003141:Communicable Diseases / Q000175:diagnosis*; D006801:Humans; D036103:Nanotechnology / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis; D016133:Polymerase Chain Reaction