title: Cytotoxic sesquiterpenoids from the fruits of Lindera communis.
abstract: A new sesquiterpenoid, namely Linerenone (1), together with three known sesquiterpenoids (2-4), were isolated from the fruits of Lindera communis. Their structures were determined by extensive spectroscopic analysis including 1D, 2D-NMR and HR-MS spectra. Compound 1 showed significant cytotoxic activity against H460, ES2 and DU145 cancer cells with IC(50) of 2.1 μg/mL, 2.8 μg/mL and 3.0 μg/mL, respectively.
authors.affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, 250062, China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Deng
authors.forename: Hao
authors.initials: H
authors.lastname: Zhong
authors.forename: Shuxiang
authors.initials: S
authors.lastname: Cui
authors.forename: Fengling
authors.initials: F
authors.lastname: Wang
authors.forename: Yanying
authors.initials: Y
authors.lastname: Xie
authors.forename: Qingqiang
authors.initials: Q
authors.lastname: Yao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D005638:Fruit; D006801:Humans; D027443:Lindera / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012717:Sesquiterpenes; C570481:linerenone