title: Evaluation of long-term clarithromycin treatment in adult Chinese Patients with chronic rhinosinusitis without nasal polyps.
abstract: OBJECTIVE
  To evaluate the efficacy of long-term clarithromycin (CAM) treatment in adult Chinese patients suffering from chronic rhinosinusitis without nasal polyps (CRSnNP).
  
  
  METHODS
  Thirty-three CRSnNP patients were enrolled and subjected to CAM treatment for 12 weeks (250 mg daily). The total nasal symptom scores (TNSS), nasal resistance and inflammatory mediators including interleukin (IL)-8 and myeloperoxidase (MPO) were evaluated at weeks 0 and 12. Quality of life (QoL) was assessed in all patients by using the Sinonasal Outcome Test 20 and Short Form 36 questionnaires.
  
  
  RESULTS
  CAM treatment significantly improved TNSS, nasal resistance and QoL, and it inhibited IL-8 and MPO production in CRSnNP patients (p < 0.05). CAM treatment was more effective for IL-8(high) CRSnNP patients than for IL-8(low) CRSnNP patients (p < 0.05).
  
  
  CONCLUSIONS
  Long-term, low-dose CAM treatment is effective and safe for the treatment of CRSnNP in Chinese patients.
authors.affiliation: Allergy and Cancer Center, Otorhinolaryngology Hospital, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Luo
authors.forename: Fenghong
authors.initials: F
authors.lastname: Chen
authors.forename: Wenlong
authors.initials: W
authors.lastname: Liu
authors.forename: Zuwang
authors.initials: Z
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.forename: Yunping
authors.initials: Y
authors.lastname: Fan
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
authors.forename: Qingling
authors.initials: Q
authors.lastname: Fu
authors.forename: Kejun
authors.initials: K
authors.lastname: Zuo
authors.forename: Jianbo
authors.initials: J
authors.lastname: Shi
authors.forename: Huabin
authors.initials: H
authors.lastname: Li
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D002908:Chronic Disease; D017291:Clarithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009298:Nasal Polyps; D015995:Prevalence; D012220:Rhinitis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin