title: Antithrombotic pharmacologic prophylaxis use during conservative and surgical management of foot and ankle disorders: a systematic review.
abstract: The use of antithrombotic pharmacologic prophylaxis during conservative or postoperative management of foot and ankle disorders is controversial. This article presents a systematic review of the incidence of deep venous thrombosis (DVT)/pulmonary embolus (PE) during management of foot and ankle disorders in patients who did or did not receive antithrombotic pharmacologic prophylaxis. Incidence of DVT/PE in both groups was low; however, more than half of the patients in both groups received some form of antithrombotic pharmacologic prophylaxis of varying duration, making it difficult to determine the true protective effect of antithrombotic pharmacologic prophylaxis.
authors.affiliation: Limb Preservation Service, Vascular/Endovascular Surgery Service, Department of Surgery, Madigan Healthcare System, Tacoma, WA 98431, USA. vlsdpm@gmail.com
authors.forename: Valerie L
authors.initials: VL
authors.lastname: Schade
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Roukis
mesh_terms: D000843:Ankle Joint / Q000473:pathology / Q000601:surgery; D000925:Anticoagulants / Q000627:therapeutic use*; D001182:Arthroscopy / Q000009:adverse effects* / Q000379:methods; D002370:Casts, Surgical / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D005528:Foot / Q000473:pathology / Q000601:surgery; D005534:Foot Diseases / Q000175:diagnosis / Q000601:surgery* / Q000628:therapy; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D007103:Immobilization / Q000009:adverse effects; D007430:Intraoperative Care / Q000379:methods*; D007592:Joint Diseases / Q000175:diagnosis / Q000601:surgery* / Q000628:therapy; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight