title: Long term regulation of cardiac L-type calcium channel by small G proteins.
abstract: Calcium ions are crucial elements of excitation-contraction coupling in cardiac myocytes. The intracellular Ca(2+ ) concentration changes continously during the cardiac cycle, but the Ca(2+ ) entering to the cell serves as an intracellular second messenger, as well. The Ca(2+ ) as a second messenger influences the activity of many intracellular signalling pathways and regulates gene expression. In cardiac myocytes the major pathway for Ca(2+ ) entry into cells is L-type calcium channel (LTCC). The precise control of LTCC function is essential for maintaining the calcium homeostasis of cardiac myocytes. Dysregulation of LTCC may result in different diseases like cardiac hypertrophy, arrhytmias, heart failure. The physiological and pathological structural changes in the heart are induced in part by small G proteins. These proteins are involved in wide spectrum of cell biological functions including protein transport, regulation of cell proliferation, migration, apoptosis, and cytoskeletal rearrangement. Understanding the crosstalk between small G proteins and LTCC may help to understand the pathomechanism of different cardiac diseases and to develop a new generation of genetically-encoded Ca(2+ ) channel inhibitors.
authors.affiliation: Department of Physiology, University of Debrecen, Nagyerdei krt. 98. H-4012 Debrecen, Hungary. magyarj@phys.dote.hu
authors.forename: J
authors.initials: J
authors.lastname: Magyar
authors.forename: A
authors.initials: A
authors.lastname: Jenes
authors.forename: K
authors.initials: K
authors.lastname: Kistamás
authors.forename: F
authors.initials: F
authors.lastname: Ruzsnavszky
authors.forename: P P
authors.initials: PP
authors.lastname: Nánási
authors.forename: J
authors.initials: J
authors.lastname: Satin
authors.forename: N
authors.initials: N
authors.lastname: Szentandrássy
authors.forename: T
authors.initials: T
authors.lastname: Bányász
mesh_terms: D002118:Calcium / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D006331:Heart Diseases / Q000378:metabolism / Q000473:pathology; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction
chemical_list: D020746:Calcium Channels, L-Type; D047428:Protein Kinase Inhibitors; D020559:Monomeric GTP-Binding Proteins; D002118:Calcium