title: Total synthesis of (+)-przewalskin B.
abstract: An efficient strategy for the total synthesis of (+)-przewalskin B is reported. The key steps feature an intermolecular S(N)2' substitution of iodoallylic phosphate with organocupper reagent, a diastereoselective organocatalytic aldol cyclization, as well as a Rh(2)(OAc)(4)-mediated intramolecular carbene insertion to the tertiary C-H bond.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
authors.forename: Xiaotao
authors.initials: X
authors.lastname: Zhuo
authors.forename: Kai
authors.initials: K
authors.lastname: Xiang
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Zhang
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Tu
mesh_terms: D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; D007202:Indicators and Reagents; C518012:Przewalskin B; D003300:Copper