title: Polyampholyte-Wrapped Carbon Nanotubes: Preparation and Internalization by Embryonic Fibroblast Cells.
abstract: The cytotoxicity and cellular uptake of carbon nanotubes (CNTs) has recently attracted considerable interest because of the issue of biosphere-nanomaterial interactions. The biocompatibility of CNTs is determined by the metal impurities in the CNTs, the size of the CNTs and the CNT dispersion states; in particular, the type of surface modifications on the CNTs affects how they interact with cells and determines their cytotoxicity and cellular uptake. In this study, biocompatible single-walled carbon nanotubes (SWNTs) wrapped with a water-soluble copolymer, poly[2-(dimethylamino)ethyl methacrylate-co-methacrylic acid] (PDM), were prepared. We report that these SWNTs have enhanced water dispersibility and cellular internalization but no significant cytotoxic activity against mouse embryonic fibroblast NIH-3T3 cells.
authors.affiliation: Department of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Buk-gu, Gwangju 500-712, South Korea.
authors.forename: Yeonju
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Buk-gu, Gwangju 500-712, South Korea. keg@gist.ac.kr.|Department of Nanobio Materials and Electronics, World-Class University (WCU), and Institute of Medical System Engineering, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Buk-gu, Gwangju 500-712, South Korea. keg@gist.ac.kr.
authors.forename: Kurt E
authors.initials: KE
authors.lastname: Geckeler
mesh_terms: D000818:Animals; D002021:Buffers; D002470:Cell Survival; D004622:Embryo, Mammalian / Q000378:metabolism*; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D037742:Nanotubes, Carbon / Q000737:chemistry*
chemical_list: D002021:Buffers; D037742:Nanotubes, Carbon