title: HLA class I haplotypes and progression of primary open-angle glaucoma.
abstract: OBJECTIVE
  To verify if patients with primary open-angle glaucoma with HLA class I haplotypes (A9-B12, A2-B40, A1-B8) associated with this disease may have a greater rate of progression than patients who do not present these haplotypes.
  
  
  METHODS
  Anatomical and functional glaucoma evaluation (cup-to-disc ratio and visual field) of 25 patients (six of them with one of the haplotypes associated with glaucoma) followed at the Glaucoma Outpatient Clinic of the University Hospital, Ribeirão Preto School of Medicine, São Paulo University (HCFMRP-USP) for ten years after typing of their HLA antigens in order to compare with their previous condition.
  
  
  RESULTS
  A greater increase of the cup-to-disc ratio was observed in patients with HLA haplotypes associated with primary open-angle glaucoma predisposition. However, no significant differences in functional damage progression or in retinal nerve fibers loss were detected between them and other patients with glaucoma.
  
  
  CONCLUSIONS
  The present results indicate an association of class I HLA haplotypes with progression of anatomic alterations of the optic nerve head in glaucomatous patients.
authors.affiliation: Department of Ophthalmology, Otorhinolaringology and Head and Neck Surgery, Ribeirão Preto School of Medicine, São Paulo University, SP, Brazil.
authors.forename: Fábio
authors.initials: F
authors.lastname: Zenha
authors.forename: Rosistele Maria Oliveira Bezerra
authors.initials: RM
authors.lastname: Castadelli
authors.forename: Neifi Hassam Saloum
authors.initials: NH
authors.lastname: Deghaide
authors.forename: Eduardo Antonio
authors.initials: EA
authors.lastname: Donadi
authors.forename: Maria de Lourdes Veronese
authors.initials: Mde L
authors.lastname: Rodrigues
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000235:genetics* / Q000503:physiopathology; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000033:anatomy & histology; D013997:Time Factors; D014794:Visual Fields / Q000502:physiology
chemical_list: D006680:HLA Antigens