title: A new approach for the comparison of conduction abnormality between arrhythmogenic right ventricular cardiomyopathy/dysplasia and Brugada syndrome.
abstract: BACKGROUND
  Right ventricular outflow tract ventricular tachycardia (RVOT-VT), arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/ARVD), and Brugada syndrome (BrS) were characterized by arrhythmias originating in the right ventricle, and the pathophysiologic mechanism underlying these arrhythmias has not been fully understood.
  
  
  METHODS
  This study consisted of 40 subjects, including 20 patients with RVOT-VT, 10 patients with BrS, and 10 ARVD patients. The parameters on the signal-averaged electrocardiography (ECG) and the frequency components recorded from the wavelet-transformed ECG were compared between the three groups. Late potentials were positive in none of the patients with RVOT-VT, seven of the patients with BrS, and all of ARVD patients.
  
  
  RESULTS
  In Brugada and ARVD patients, the power of high-frequency components (80-150 Hz) was developed to a greater extent than in RVOT-VT patients. In the power analysis of the high-frequency components between BrS and ARVD, the frequency showing the greatest power was significantly higher in ARVD patients than that in BrS patients (145.4 ± 27.9 Hz vs 81.7 ± 19.9 Hz, P < 0.01).
  
  
  CONCLUSIONS
  High-frequency components were developed in ARVD and BrS, but not in RVOT-VT. The frequency levels showing high power by wavelet analysis obviously differ between ARVD and BrS. Wavelet analysis may provide new insight into unsolved mechanisms in arrhythmogenic right heart disease.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan. yodo@nms.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Yodogawa
authors.forename: Norishige
authors.initials: N
authors.lastname: Morita
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Takayama
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ohara
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Seino
authors.forename: Takao
authors.initials: T
authors.lastname: Katoh
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Mizuno
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D053840:Brugada Syndrome / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D016009:Chi-Square Distribution; D017147:Defibrillators, Implantable; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000379:methods*; D015716:Electrocardiography, Ambulatory; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy