title: Healing of experimental apical periodontitis after apicoectomy using different sealing materials on the resected root end.
abstract: This study evaluated apical periodontal healing after root-end sealing using 4-META/MMA-TBB resin (SB), and root-end filling using reinforced zinc oxide eugenol cement (EBA) or mineral trioxide aggregate (MTA) when root canal infection persisted. Apical periodontitis was induced in mandibular premolars of beagles by contaminating the root canals with dental plaque. After 1 month, in the SB group, SB was applied to the resected surface following apicoectomy. In the EBA and MTA groups, a root-end cavity was prepared and filled with EBA or MTA. In the control group, the root-end was not filled. Fourteen weeks after surgery, histological and radiographic analyses in a beagle model were performed. The bone defect area in the SB, EBA and MTA groups was significantly smaller than that in the control group. The result indicated that root-end sealing using SB and root-end filling using EBA or MTA are significantly better than control.
authors.affiliation: Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan. kaohtani@den.hokudai.ac.jp
authors.forename: Kaori
authors.initials: K
authors.lastname: Otani
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sugaya
authors.forename: Mahito
authors.initials: M
authors.lastname: Tomita
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Miyaji
authors.forename: Taichi
authors.initials: T
authors.lastname: Tenkumo
authors.forename: Saori
authors.initials: S
authors.lastname: Tanaka
authors.forename: Youji
authors.initials: Y
authors.lastname: Motoki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takanawa
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Kawanami
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001047:Apicoectomy / Q000379:methods*; D001641:Bicuspid / Q000473:pathology; D001896:Boron Compounds / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry; D003738:Dental Cements / Q000737:chemistry*; D003739:Dental Cementum / Q000473:pathology; D003773:Dental Plaque / Q000382:microbiology; D003786:Dental Pulp Cavity / Q000382:microbiology; D003804:Dentin / Q000473:pathology; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D008689:Methacrylates / Q000737:chemistry; D008768:Methylmethacrylates / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D010485:Periapical Periodontitis / Q000000981:diagnostic imaging / Q000628:therapy*; D010486:Periapical Tissue / Q000473:pathology; D011859:Radiography; D011897:Random Allocation; D019279:Resin Cements / Q000737:chemistry; D012184:Retrograde Obturation / Q000379:methods*; D018915:Root Canal Preparation / Q000379:methods; D017640:Silicates / Q000737:chemistry; D014945:Wound Healing / Q000502:physiology; D015035:Zinc Oxide-Eugenol Cement / Q000737:chemistry
chemical_list: D017607:Aluminum Compounds; D001896:Boron Compounds; D017610:Calcium Compounds; D003738:Dental Cements; D004338:Drug Combinations; D008689:Methacrylates; D008768:Methylmethacrylates; D010087:Oxides; D019279:Resin Cements; D017640:Silicates; D015035:Zinc Oxide-Eugenol Cement; C086631:mineral trioxide aggregate; C049495:Super-bond