title: [Novel regulatory mechanism of bone metabolism].
abstract: Recent advances of molecular biology uncovered novel regulatory mechanisms of bone remodeling such as neuronal control of bone remodeling. Of these, leptin-serotonin-sympathetic nervous system pathway plays a major role as evident from the fact that beta-blockers reduced the risk of osteoporotic fractures in human. MicroRNA, a major class of non-coding RNA, is also a new player in the field of bone remodeling. Neuronal and microRNA-dependent pathways are promising candidates for new therapeutic applications for osteoporosis treatment.
authors.affiliation: Section of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Keio University School of Medicine.
authors.forename: Shu
authors.initials: S
authors.lastname: Takeda
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D013564:Sympathetic Nervous System
chemical_list: D020738:Leptin; D035683:MicroRNAs; D009479:Neuropeptides; D012701:Serotonin