title: Auditory and vestibular hair cell stereocilia: relationship between functionality and inner ear disease.
abstract: The stereocilia of the inner ear are unique cellular structures which correlate anatomically with distinct cochlear functions, including mechanoelectrical transduction, cochlear amplification, adaptation, frequency selectivity and tuning. Their function is impaired by inner ear stressors, by various types of hereditary deafness, syndromic hearing loss and inner ear disease (e.g. Ménière's disease). The anatomical and physiological characteristics of stereocilia are discussed in relation to inner ear malfunctions.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Marienhospital Gelsenkirchen, Germany. ciuman.raphael@cityweb.de
authors.forename: R R
authors.initials: RR
authors.lastname: Ciuman
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D002118:Calcium / Q000502:physiology; D002648:Child; D006198:Hair Cells, Auditory / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D018069:Hair Cells, Vestibular / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D006801:Humans; D007759:Labyrinth Diseases / Q000378:metabolism / Q000503:physiopathology*; D040542:Mechanotransduction, Cellular / Q000502:physiology; D009218:Myosins / Q000378:metabolism; D055139:Sensory Gating / Q000502:physiology; D059547:Stereocilia / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D052245:Usher Syndromes / Q000145:classification / Q000235:genetics* / Q000503:physiopathology
chemical_list: D009218:Myosins; D002118:Calcium