title: The charms and challenges of antiretroviral therapy in Uganda: the DART experience.
abstract: Antiretroviral therapy (ART) improves the quality of life of people living with HIV/AIDS. However, adherence remains a challenge. A total of eight focus group discussions (FGD) were conducted with participants from a randomised controlled trial that monitored strategies for managing ART in African adults: Development of Antiretroviral Therapy. All FGD participants had received ART for at least one year. Perceived benefits of ART were key motivators for adherence. These benefits included improved physical health, restored self-esteem, acceptance in the community and hope for a longer and healthier life and reduced fear of HIV/AIDS-related death. Barriers to adherence included a high pill burden, ART side effects and socio-economic constraints, including lack of food and safe water for taking the pills. Visible ART side effects and involvement in an exclusively HIV/AIDS clinic could expose their HIV status, thus exacerbating stigma. Gender and socio-economic differences were found in the variety of strategies employed to ensure adherence. ART was perceived as improving the overall quality of life of recipients; however, it is crucial for ART programmes to be gender and socio-economic cognizant in order to enhance adherence to a lifelong therapy.
authors.affiliation: MRC/UVRI Uganda AIDS Research Unit, Entebbe, Uganda. barbara.nyanzi@mrcuganda.org
authors.forename: Barbara
authors.initials: B
authors.lastname: Nyanzi-Wakholi
authors.forename: Antonieta Medina
authors.initials: AM
authors.lastname: Lara
authors.forename: Paula
authors.initials: P
authors.lastname: Munderi
authors.forename: Charles
authors.initials: C
authors.lastname: Gilks
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005260:Female; D017144:Focus Groups; D015658:HIV Infections / Q000188:drug therapy*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D036301:Qualitative Research; D014454:Uganda; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents