title: [Inhibitory effect of somatostatin analogue octreotide on the expression of p53 and Ras in human gastric cancer].
abstract: OBJECTIVE
  To investigate the inhibitory effect of somatostatin (SST) analogue octreotide on human gastric cancer.
  
  
  METHODS
  Fifty gastric cancer patients were randomly assigned into 2 equal groups. The patients in the control group received no medication before surgical resection of gastric cancer, and those in octreotide group were given daily subcutaneous injection of 100 µg octreotide for 7 days before the surgery. The resected specimens were examined histologically and the expressions of p53 and Ras protein were detected by immunohistochemistry.
  
  
  RESULTS
  Compared with the control group, gastric cancer tissue in octreotide group showed significantly increased necrosis (P<0.05) and enhanced proliferation of fibrous tissues (P<0.05) with lowered expressions of p53 and Ras protein (P<0.05).
  
  
  CONCLUSIONS
  Octreotide can inhibit the expressions of p53 and Ras and suppress the growth of the human gastric cancer.
authors.affiliation: Department of Gastroenterology, First Affiliated Hospital of Liaoning medical University, Jinzhou 121001, China. tljinzhou@126.com
authors.forename: Lei
authors.initials: L
authors.lastname: Tian
authors.forename: Shu
authors.initials: S
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics / Q000378:metabolism*; D013004:Somatostatin / Q000031:analogs & derivatives*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D013004:Somatostatin; D016283:Proto-Oncogene Proteins p21(ras); D015282:Octreotide