title: The 'invisible hand': regulation of RHO GTPases by RHOGDIs.
abstract: The 'invisible hand' is a term originally coined by Adam Smith in The Theory of Moral Sentiments to describe the forces of self-interest, competition and supply and demand that regulate the resources in society. This metaphor continues to be used by economists to describe the self-regulating nature of a market economy. The same metaphor can be used to describe the RHO-specific guanine nucleotide dissociation inhibitor (RHOGDI) family, which operates in the background, as an invisible hand, using similar forces to regulate the RHO GTPase cycle.
authors.affiliation: Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA. rafaelgm@med.unc.edu
authors.forename: Rafael
authors.initials: R
authors.lastname: Garcia-Mata
authors.forename: Etienne
authors.initials: E
authors.lastname: Boulter
authors.forename: Keith
authors.initials: K
authors.lastname: Burridge
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D020730:Guanine Nucleotide Dissociation Inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000378:metabolism; D046912:Multiprotein Complexes; D009369:Neoplasms / Q000378:metabolism; D010766:Phosphorylation; D010802:Phylogeny; D054730:Protein Interaction Domains and Motifs; D020741:rho GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D062948:rho Guanine Nucleotide Dissociation Inhibitor alpha; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors
chemical_list: C569638:ARHGDIA protein, human; D020730:Guanine Nucleotide Dissociation Inhibitors; D018832:Molecular Chaperones; D046912:Multiprotein Complexes; D062948:rho Guanine Nucleotide Dissociation Inhibitor alpha; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors; D020741:rho GTP-Binding Proteins