title: Targeted endoradiotherapy using nucleotides.
abstract: Increased cellular proliferation is an integral part of the cancer phenotype. Hence, the sustained and continued demand on supply of DNA building blocks during the DNA replication presents a potential target for therapeutic intervention. For this propose, the α and Auger electron emitting nucleotides analogs are attractive for targeted endoradiotherapy, given that DNA of malignant cells is selectively addressed. This review summarizes development and preclinical and clinical studies of endoradiotherapeutic acting nucleoside analogs with a special focus on thymidine analogs.
authors.affiliation: Department of Nuclear Medicine, University Hospital Aachen, RWTH, Pauwelsstraße 30, D-52074 Aachen, Germany. amorgenroth@ukaachen.de
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Morgenroth
authors.forename: Andreas T
authors.initials: AT
authors.lastname: Vogg
authors.forename: Felix M
authors.initials: FM
authors.lastname: Mottaghy
authors.forename: Jörn
authors.initials: J
authors.lastname: Schmaljohann
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000528:radiation effects; D006801:Humans; D009711:Nucleotides / Q000008:administration & dosage; D011829:Radiation Dosage; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D011878:Radiotherapy / Q000379:methods*
chemical_list: D009711:Nucleotides; D019275:Radiopharmaceuticals