title: Malignant transformation of a desmoplastic infantile ganglioglioma.
abstract: We describe a rare case of desmoplastic infantile ganglioglioma that appears to have transformed into a glioblastoma multiforme tumor in a 5-year-old girl. The patient was initially treated with total removal of the tumor, without subsequent radiation therapy or chemotherapy. She was in good health for 3 years, but manifested a sudden onset of seizures, followed by severe headache, vomiting, and left-sided weakness. Cranial magnetic resonance imaging revealed a large mass with rim enhancement at the previously operated site. The mass was completely removed, and the pathology report revealed glioblastoma multiforme. Postoperative chemotherapy and radiation treatment were administered. She has been followed for 11 years, and is alive without recurrence.
authors.affiliation: Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Joon-Khim
authors.initials: JK
authors.lastname: Loh
authors.forename: Ann-Shung
authors.initials: AS
authors.lastname: Lieu
authors.forename: Chee-Yin
authors.initials: CY
authors.lastname: Chai
authors.forename: Shen-Long
authors.initials: SL
authors.lastname: Howng
mesh_terms: D000293:Adolescent; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D018303:Ganglioglioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005909:Glioblastoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D015173:Supratentorial Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery