title: Ferrocenyl Schiff base as novel antioxidant to protect DNA against the oxidation damage.
abstract: The antioxidant capacities of ferrocenyl Schiff bases including o-(1-ferrocenylethylideneamino)phenol (OFP), m-(1-ferrocenylethylideneamino)phenol (MFP), and p-(1-ferrocenylethylideneamino)phenol (PFP) were evaluated in 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH), Cu(2+)/glutathione (GSH), and hydroxyl radical (()OH)-induced oxidation of DNA, and in trapping 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical (ABTS+(.)), respectively. OFP, MFP and PFP possessed similar activities to trap DPPH and ABTS+(.). All the ferrocenyl Schiff bases employed herein behaved as prooxidants in Cu(2+)/GSH- and (.)OH-induced oxidation of DNA except that OFP exhibited weak antioxidant activity in ()OH-induced oxidation of DNA. PFP, OFP and MFP can terminate about 15.2, 11.3, and 9.4 radical-chain-propagations in AAPH-induced oxidation of DNA. Especially, the introduction of ferrocenyl group to Schiff base increased the antioxidant effectiveness more remarkably than benzene-related Schiff bases.
authors.affiliation: Department of Organic Chemistry, College of Chemistry, Jilin University, No. 2519 Jiefang Road, Changchun, China.
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Li
authors.forename: Zai-Qun
authors.initials: ZQ
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D004249:DNA Damage / Q000187:drug effects*; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005609:Free Radicals / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D005296:Ferrous Compounds; D005609:Free Radicals; D016877:Oxidants; D010851:Picrates; D012545:Schiff Bases; D004247:DNA; C004931:1,1-diphenyl-2-picrylhydrazyl