title: Growth hormone and testosterone: anabolic effects on muscle.
abstract: BACKGROUND
  The loss of skeletal muscle mass that occurs with aging, chronic disease or acute injury is clinically important in the health of humans. The mechanisms relating to the synthesis and breakdown of skeletal muscle are now being intensely investigated. Current studies and possible mechanisms for skeletal muscle protein synthesis and degradation will be reviewed with a specific focus on growth hormone and testosterone.
  
  
  CONCLUSIONS
  Investigation of the mechanisms of action of growth hormone and testosterone in skeletal muscle will likely lead to new therapies to prevent skeletal muscle loss and new awareness of the importance of skeletal muscle in health and disease.
authors.affiliation: Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0569, USA. rurban@utmb.edu
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Urban
mesh_terms: D000375:Aging / Q000502:physiology; D045930:Anabolic Agents / Q000494:pharmacology*; D005260:Female; D019382:Human Growth Hormone / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D008297:Male; D009124:Muscle Proteins / Q000187:drug effects / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D055948:Sarcopenia / Q000188:drug therapy; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology
chemical_list: D045930:Anabolic Agents; D009124:Muscle Proteins; D019382:Human Growth Hormone; D013739:Testosterone