title: [Impact of gender on the dose-effect relationship of cisatracurium].
abstract: OBJECTIVE
  To evaluate the impact of gender differences on the dose-effect relationship of cisatracurium.
  
  
  METHODS
  Eighty ASA class I or II patients (40 male and 40 female patients) undergoing elective abdominal surgeries received a single-dose intravenous injection of midazolam and fentanyl. The male and female patients were subdivided into 4 equal groups to receive a intravenous bolus of 20, 30, 40, or 50 µg/kg of cisatracurium. The neuromuscular block was measured using a neuromuscular transmission monitor, and the responses were defined in terms of the percentages of maximum suppression in T1 of TOF of the adductor pollicis muscle. According to log-probit transformation of the data of the dose and response, the dose-response curve of cisatracurium was established through linear regression. The onset time of vecuronium was also observed.
  
  
  RESULTS
  The ED95 value of cisatracurium in male patients was 67.4±4.4 µg/kg, significantly higher than that in female patients (48.7±1.0 µg/kg, P<0.05). No significant variation in the onset time was found in the 4 dose groups of either male or female patients (P>0.05).
  
  
  CONCLUSIONS
  Female patients are more sensitive to cisatracurium than male patients.
authors.affiliation: Department of Anesthesiology, Xingning People's Hospital, Xingning 514500, China. xnshihongjin@126.com
authors.forename: Hong-jin
authors.initials: HJ
authors.lastname: Shi
authors.forename: Qi-bo
authors.initials: QB
authors.lastname: Liang
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D001279:Atracurium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D008297:Male; D019148:Neuromuscular Blockade / Q000379:methods; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000069437:Pharmacological Phenomena / Q000502:physiology*; D012737:Sex Factors; D055815:Young Adult
chemical_list: D009466:Neuromuscular Blocking Agents; D001279:Atracurium; C101584:cisatracurium