title: Symptomatic 5-fluorouracil-induced sinus bradycardia.
abstract: 5-Fluorouracil (5-FU) is a commonly used anti-neoplastic agent. 5-FU has been not uncommonly associated with cardiotoxicity, although the many potentially causative mechanisms are yet to be established. Here, we present the case of a 61-year-old gemstone miner who developed symptomatic sinus bradycardia while receiving a continuous 5-FU infusion combined with radiotherapy for locally advanced rectal cancer. This dysrhythmia is an unusual type of 5-FU toxicity, our case being the second described. We review the actions of 5-FU and the various proposed mechanisms of its cardiotoxic effects.
authors.affiliation: Radiation Oncology Department, The Canberra Hospital, Canberra, Australian Capital Territory, Australia. drandrewlee@me.com
authors.forename: A D
authors.initials: AD
authors.lastname: Lee
authors.forename: M J
authors.initials: MJ
authors.lastname: McKay
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D001146:Arrhythmia, Sinus / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D001919:Bradycardia / Q000139:chemically induced* / Q000503:physiopathology; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000150:complications / Q000188:drug therapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil