title: Right time - right location - right move: TRPs find motors for common functions.
abstract: TRP channels are localized at specialized sub-cellular compartments like filopodial tips, ciliary structures, growth cones and spines that have importance in the context of several sensory functions. Several motor proteins largely regulate these localizations. Recent studies indicate that both physical and genetic interactions exist between TRP channels with actin and microtubule-based motor proteins. These two groups of proteins share specialized and fine regulation underlying physiological functions. Indeed, mutations causing loss of these interactions and regulations result in development of pathophysiological disorders and syndromes. In this review we analyze the recent progress made in cell-biological, biochemical, electrophysiological and genetic studies and summarize the multi-dimensional crosstalk between TRP channels with different motor proteins.
authors.affiliation: National Institute of Science Education and Research, Bhubaneswar, Orissa India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Majhi
authors.forename: Puspendu
authors.initials: P
authors.lastname: Sardar
authors.forename: Luna
authors.initials: L
authors.lastname: Goswami
authors.forename: Chandan
authors.initials: C
authors.lastname: Goswami
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002923:Cilia / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D011554:Pseudopodia / Q000235:genetics / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000378:metabolism*
chemical_list: D000199:Actins; D008869:Microtubule-Associated Proteins; D050051:Transient Receptor Potential Channels