title: High-frequency and low-frequency chest compression: effects on lung water secretion, mucus transport, heart rate, and blood pressure using a trapezoidal source pressure waveform.
abstract: High-frequency chest compression (HFCC), using an appropriate source (pump) waveform for frequencies at or above 3 Hz, can enhance pulmonary clearance for patients with cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Using a trapezoidal HFCC source pressure waveform, secretion of water from epithelial tissue and transport of mucus through lung airways can be enhanced for patients with CF and COPD. At frequencies below 3 Hz, low-frequency chest compression (LFCC) appears to have a significant impact on the cardiovascular system. For a trapezoidal source pressure waveform at frequencies close to 1 Hz, LFCC produces amplitude or intensity variations in various components of the electrocardiogram time-domain waveform, produces changes at very low frequencies associated with the electrocardiogram frequency spectra (indicating enhanced parasympathetic nervous system activity), and promotes a form of heart rate synchronization. It appears that LFCC can also provide additional cardiovascular benefits by reducing peak and average systolic and diastolic blood pressure for patients with hypertension.
authors.affiliation: Defense of the Lungs Project, Pulmonary Disease/Critical Care, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. ocloc002@umn.edu
authors.forename: George D
authors.initials: GD
authors.lastname: O'Clock
authors.forename: Yong Wan
authors.initials: YW
authors.lastname: Lee
authors.forename: Jongwong
authors.initials: J
authors.lastname: Lee
authors.forename: Warren J
authors.initials: WJ
authors.lastname: Warwick
mesh_terms: D001693:Biological Transport, Active; D001794:Blood Pressure; D001834:Body Water / Q000378:metabolism*; D035641:Chest Wall Oscillation / Q000379:methods*; D003198:Computer Simulation; D003550:Cystic Fibrosis / Q000503:physiopathology / Q000534:rehabilitation; D006339:Heart Rate; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008954:Models, Biological; D009093:Mucus / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000534:rehabilitation; D013813:Therapy, Computer-Assisted / Q000379:methods