title: Chromosome formation during fertilization in eggs of the teleost Oryzias latipes.
abstract: Upon fertilization, eggs shift their cell cycle from the meiotic to the mitotic pattern for embryogenesis. The information on chromosome formation has been accumulated by various experiments using inhibitors to affect formation and behavior of chromosomes in the cycle of cell proliferation. Based on experimental results on meiosis and early stages of development of the teleost Oryzias latipes, we discuss the roles of the activities of histone H1 kinase, microtubule-associated protein kinase, DNA polymerase, DNA topoisomerase, and other cytoplasmic factors that play a crucial role in formation and separation of chromosomes.
authors.affiliation: Aichi University of Education, 448-0001, Karia, Japan. iwamatsu@na.commufa.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwamatsu
mesh_terms: D000818:Animals; D016590:Aphidicolin / Q000494:pharmacology; D002453:Cell Cycle / Q000235:genetics; D002875:Chromosomes / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D005306:Fertilization / Q000235:genetics*; D008540:Meiosis / Q000187:drug effects / Q000235:genetics; D008845:Microinjections; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D009865:Oocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009990:Oryzias / Q000235:genetics*; D011494:Protein Kinases / Q000378:metabolism; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors; D011500:Protein Synthesis Inhibitors; D016590:Aphidicolin; D011494:Protein Kinases; C102333:histone H1 kinase