title: [A case of unresectable advanced gastric cancer treated with S-1/low-dose CDDP combination chemotherapy through jejunostomy].
abstract: A 70-year-old woman with unresectable advanced gastric cancer accompanied by peritoneal dissemination underwent jejunostomy, and was treated with S-1 and low-dose CDDP. One course consisted of S-1 (80 mg/day) via an intestinal fistula tube from days 1 to 14. This was followed by 7 days rest, and CDDP (20 mg/day) was administered by 1-hour continuous intravenous infusion on day 1 and 8. She continued to receive this chemotherapy for a total of 14 courses, followed by 3 courses of a weekly paclitaxel regimen. She died 14 months after surgery. All chemotherapy had been conducted in an outpatient setting. We concluded that the administration of S-1, combined with low-dose CDDP (div) through a jejunostomy, can improve the quality of life (QOL) of a patient who has unresectable advanced gastric and is incapable of oral intake. We report this rare case with a review of the literature.
authors.affiliation: Dept. of Surgery, Japanese Red Cross Kyoto Daiichi Hospital, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Sonoda
authors.forename: Junichi
authors.initials: J
authors.lastname: Hamada
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shimomura
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Itokawa
authors.forename: Jun
authors.initials: J
authors.lastname: Ikeda
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Taniguchi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ueshima
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Takashina
authors.forename: Choljee
authors.initials: C
authors.lastname: Lee
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shioaki
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004338:Drug Combinations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007582:Jejunostomy; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000556:secondary; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin