title: GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data.
abstract: BACKGROUND
  The increasing availability of HIV-host interaction datasets, including both physical and genetic interactions, has created a need for software tools to integrate and visualize the data. Because these host-pathogen interactions are extensive and interactions between human proteins are found within many different databases, it is difficult to generate integrated HIV-human interaction networks.
  
  
  RESULTS
  We have developed a web-based platform, termed GPS-Prot http://www.gpsprot.org, that allows for facile integration of different HIV interaction data types as well as inclusion of interactions between human proteins derived from publicly-available databases, including MINT, BioGRID and HPRD. The software has the ability to group proteins into functional modules or protein complexes, generating more intuitive network representations and also allows for the uploading of user-generated data.
  
  
  CONCLUSIONS
  GPS-Prot is a software tool that allows users to easily create comprehensive and integrated HIV-host networks. A major advantage of this platform compared to other visualization tools is its web-based format, which requires no software installation or data downloads. GPS-Prot allows novice users to quickly generate networks that combine both genetic and protein-protein interactions between HIV and its human host into a single representation. Ultimately, the platform is extendable to other host-pathogen systems.
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California San Francisco, 1700 4th Street, San Francisco, CA 94158, USA.
authors.forename: Marie E
authors.initials: ME
authors.lastname: Fahey
authors.forename: Melanie J
authors.initials: MJ
authors.lastname: Bennett
authors.forename: Cathal
authors.initials: C
authors.lastname: Mahon
authors.forename: Stefanie
authors.initials: S
authors.lastname: Jäger
authors.forename: Lars
authors.initials: L
authors.lastname: Pache
authors.forename: Dhiraj
authors.initials: D
authors.lastname: Kumar
authors.forename: Alex
authors.initials: A
authors.lastname: Shapiro
authors.forename: Kanury
authors.initials: K
authors.lastname: Rao
authors.forename: Sumit K
authors.initials: SK
authors.lastname: Chanda
authors.forename: Charles S
authors.initials: CS
authors.lastname: Craik
authors.forename: Alan D
authors.initials: AD
authors.lastname: Frankel
authors.forename: Nevan J
authors.initials: NJ
authors.lastname: Krogan
mesh_terms: D015658:HIV Infections / Q000378:metabolism*; D015497:HIV-1; D054884:Host-Pathogen Interactions; D006801:Humans; D020407:Internet; D025941:Protein Interaction Mapping; D012984:Software; D049490:Systems Biology / Q000379:methods*; D014584:User-Computer Interface