title: A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice.
abstract: Research into an efficacious Chlamydia trachomatis vaccine is ongoing, however, there has been no examination into the timing of vaccine administration to either asymptomatically or previously infected individuals. Using the female Chlamydia muridarum genital tract mouse model, we examined this aspect of vaccine development. Our results show timing of vaccination affected the production of systemic antibodies, but had minimal effects on mucosal antibody production. Vaccination during an active infection or after a resolved infection did not provide protection against re-exposure to Chlamydia, and did not exacerbate the development of pathological sequelae in infected mice. This demonstrates that vaccination may not be protective in individuals who are seropositive for an acute or previous chlamydial infection.
authors.affiliation: Institute of Health & Biomedical Innovation, Cell & Molecular Biosciences, Faculty of Science, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia.
authors.forename: Alison
authors.initials: A
authors.lastname: Carey
authors.forename: Kelly
authors.initials: K
authors.lastname: Cunningham
authors.forename: Dean
authors.initials: D
authors.lastname: Andrew
authors.forename: Louise
authors.initials: L
authors.lastname: Hafner
authors.forename: Peter
authors.initials: P
authors.lastname: Timms
authors.forename: Kenneth
authors.initials: K
authors.lastname: Beagley
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000097:blood; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D002690:Chlamydia Infections / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology / Q000517:prevention & control; D023502:Chlamydia muridarum / Q000302:isolation & purification*; D004195:Disease Models, Animal; D005260:Female; D018928:Immunity, Mucosal; D051379:Mice; D008807:Mice, Inbred BALB C; D012376:Rodent Diseases / Q000276:immunology / Q000382:microbiology; D014552:Urinary Tract Infections / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology / Q000517:prevention & control; D014611:Vaccination / Q000379:methods
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines