title: A case of an ectopic prolactinoma.
abstract: A 34-year-old female presented to our clinic with a 1.5 year history of secondary amenorrhea and galactorrhea. Prolactin (PRL) level was found to be 151.89 ng/ml. Pituitary imaging was reported to be normal. An examination of the patient revealed that PRL level was still high so the dose of cabergoline was further increased and subsequently, bromocriptine was added to the treatment. There was no reduction in PRL levels in controls. A scanning was performed to look for an ectopic focus. Abdominal computerized tomography revealed a heterogenous mass lesion originating from the uterus. Octreotide scintigraphy was performed and we observed an involvement consistent with the mass in the uterus. The patient underwent abdominal total hysterectomy. PRL dropped to 0.4 ng/ml the next day after the operation. The pathology result was a low-grade malignant mesenchymal tumor. Prolactin was found to be immunohistochemically negative. However, galactorrhea disappeared postoperative and PRL levels are still low. Elevated levels of PRL, resistant to bromocriptine and cabergoline, rapidly returned to normal after hysterectomy, which obviously indicates that hyperprolactinemia was associated with the myoma of the uterus.
authors.affiliation: Ege University Medical Faculty, Deparment of Internal Medicine, Division of Endocrinology and Metabolism, Izmir, Turkey. ilginyildirim@hotmail.com
authors.forename: Ilgin Yildirim
authors.initials: IY
authors.lastname: Simsir
authors.forename: Gokcen Unal
authors.initials: GU
authors.lastname: Kocabas
authors.forename: Serap Baydur
authors.initials: SB
authors.lastname: Sahin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erdogan
authors.forename: Sevki
authors.initials: S
authors.lastname: Cetinkalp
authors.forename: Fusun
authors.initials: F
authors.lastname: Saygili
authors.forename: Candeger
authors.initials: C
authors.lastname: Yilmaz
authors.forename: Ahmet Gokhan
authors.initials: AG
authors.lastname: Ozgen
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D005260:Female; D005687:Galactorrhea / Q000209:etiology; D006801:Humans; D007044:Hysterectomy; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D014594:Uterine Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000601:surgery
chemical_list: D011388:Prolactin