title: Metastatic collecting duct carcinoma of the kidney treated with sunitinib.
abstract: Collecting duct carcinoma (CDC) of the kidney is a rare and aggressive malignant tumor arising from the distal collecting tubules which has been shown to have a poor response to several kinds of systemic therapy. We present a case of metastatic CDC that responded favorably to a multiple tyrosine kinase inhibitor, sunitinib, achieving a partial response in both lung and skeletal metastases. To our knowledge, this is the first report showing therapeutic activity of sunitinib against CDC. Considering these findings, it would be worthwhile prospectively investigating the role of multiple tyrosine kinase inhibitors, particularly sunitinib, in the management of metastatic CDC.
authors.affiliation: Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco. moulay.elmehdi@yahoo.fr
authors.forename: El Mehdi
authors.initials: EM
authors.lastname: Tazi
authors.forename: Ismail
authors.initials: I
authors.lastname: Essadi
authors.forename: Mohamed Fadl
authors.initials: MF
authors.lastname: Tazi
authors.forename: Youness
authors.initials: Y
authors.lastname: Ahellal
authors.forename: Hind
authors.initials: H
authors.lastname: M'rabti
authors.forename: Hassan
authors.initials: H
authors.lastname: Errihani
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011758:Pyrroles / Q000627:therapeutic use*; D012272:Ribs; D000077210:Sunitinib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib