title: Investigation of platelet adhesiveness in patients with coronary artery disease and acute myocardial infarction using the platelet adhesion assay (PADA).
abstract: BACKGROUND
  Increased platelet reactivity may contribute to the development of coronary artery disease and myocardial infarction. The aim of the present study was to assess platelet adhesiveness in different stages of coronary artery disease using the platelet adhesion assay (PADA). In addition, the acute effect of coronary angiography and stent implantation on platelet adhesiveness was examined.
  
  
  METHODS
  85 patients with stable coronary artery disease (SAP - stable angina pectoris) and 19 patients with acute myocardial infarction (AMI) were enrolled in the study. 35 volunteers served as controls. Blood sampling in SAP and AMI patients was done before coronary angiography to measure the adhesion index (AI) using the PADA. In 33 patients additional blood was drawn at the end of coronary angiography. In 6 patients blood samples were drawn also after stent implantation.
  
  
  RESULTS
  In blood samples from patients with an AMI the AI was significantly higher than in blood samples from the SAP group (p < 0.01) and the control group (p < 0.01). Coronary angiography and stent implantation did not result in significant acute changes in mean AI however results show an interindividual variability in initial values as well as in AI changes during procedures.
  
  
  CONCLUSIONS
  This is the first study to show that PADA, a quick and simple laboratory method for the quantitative determination of platelet adhesiveness, is able to detect platelet hyper-adhesiveness in patients with AMI.
authors.affiliation: University Medical Centre Mannheim, First Department of Medicine (Cardiology), Mannheim, Germany. thomas.walter.med@umm.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Walter
authors.forename: Sebastian
authors.initials: S
authors.lastname: Szabo
authors.forename: Silke
authors.initials: S
authors.lastname: Kazmaier
authors.forename: Tim
authors.initials: T
authors.lastname: Suselbeck
authors.forename: Götz
authors.initials: G
authors.lastname: Nowak
authors.forename: Martin
authors.initials: M
authors.lastname: Borggrefe
authors.forename: Hans M
authors.initials: HM
authors.lastname: Hoffmeister
authors.forename: Carl E
authors.initials: CE
authors.lastname: Dempfle
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy; D009204:Myocardial Revascularization; D010973:Platelet Adhesiveness; D010979:Platelet Function Tests; D015607:Stents; D019851:Thrombophilia / Q000209:etiology