title: Oleanane-type triterpenoids from the leaves and twigs of Fatsia polycarpa.
abstract: Seven new oleanane-type triterpenoids (1-7), named fatsicarpains A-G, and the known compounds 3α-hydroxyolean-11,13(18)-dien-28-oic acid (8) and 3α-hydroxyolean-11-en-28,13β-olide (9) were isolated from the leaves and twigs of Fatsia polycarpa on the basis of bioassay-guided fractionation. The structures of compounds 1-7 were elucidated through spectroscopic analyses and single-crystal X-ray crystallography of 1, 8, and 9. Cytotoxicity against HepG2 2.2.15 and AGS cells and antihepatitis B virus (HBV) and antibacterial activities of 1-9 were also evaluated in vitro.
authors.affiliation: Research Center for Biodiversity, China Medical University , Taichung 40402, Taiwan, Republic of China.
authors.forename: Shi-Yie
authors.initials: SY
authors.lastname: Cheng
authors.forename: Chao-Min
authors.initials: CM
authors.lastname: Wang
authors.forename: Yuan-Man
authors.initials: YM
authors.lastname: Hsu
authors.forename: Tsurng-Juhn
authors.initials: TJ
authors.lastname: Huang
authors.forename: Shen-Chieh
authors.initials: SC
authors.lastname: Chou
authors.forename: En-Hung
authors.initials: EH
authors.lastname: Lin
authors.forename: Chang-Hung
authors.initials: CH
authors.lastname: Chou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027481:Araliaceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C561843:fatsicarpain A; C413246:oleanane; D009828:Oleanolic Acid