title: Long term in vitro functional stability and recording longevity of fully integrated wireless neural interfaces based on the Utah Slant Electrode Array.
abstract: We evaluate the encapsulation and packaging reliability of a fully integrated wireless neural interface based on a Utah Slant Electrode Array/integrated neural interface-recording version 5 (USEA/INI-R5) system by monitoring the long term in vitro functional stability and recording longevity. The INI encapsulated with 6 µm Parylene-C was immersed in phosphate buffered saline (PBS) for a period of over 276 days (with the monitoring of the functional device still ongoing). The full functionality (wireless radio-frequency power, command and signal transmission) and the ability of the electrodes to record artificial neural signals even after 276 days of PBS soaking with little change (within 14%) in signal/noise amplitude constitute a major milestone in long term stability and allow us to study and evaluate the encapsulation reliability, functional stability and its potential usefulness for a wireless neural interface for future chronic implants.
authors.affiliation: Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT 84112, USA. asha.sharma@utah.edu
authors.forename: Asha
authors.initials: A
authors.lastname: Sharma
authors.forename: Loren
authors.initials: L
authors.lastname: Rieth
authors.forename: Prashant
authors.initials: P
authors.lastname: Tathireddy
authors.forename: Reid
authors.initials: R
authors.lastname: Harrison
authors.forename: Hermann
authors.initials: H
authors.lastname: Oppermann
authors.forename: Matthias
authors.initials: M
authors.lastname: Klein
authors.forename: Michael
authors.initials: M
authors.lastname: Töpper
authors.forename: Erik
authors.initials: E
authors.lastname: Jung
authors.forename: Richard
authors.initials: R
authors.lastname: Normann
authors.forename: Gregory
authors.initials: G
authors.lastname: Clark
authors.forename: Florian
authors.initials: F
authors.lastname: Solzbacher
mesh_terms: D000200:Action Potentials / Q000502:physiology; D002021:Buffers; D003198:Computer Simulation; D004567:Electrodes, Implanted; D004581:Electronics; D008838:Microcomputers; D009474:Neurons / Q000502:physiology; D010710:Phosphates; D011108:Polymers; D011474:Prosthesis Design; D012685:Sepharose; D014584:User-Computer Interface; D059015:Wireless Technology; D014992:Xylenes
chemical_list: D002021:Buffers; D010710:Phosphates; D011108:Polymers; D014992:Xylenes; C011055:parylene; D012685:Sepharose