title: HIV infection as a predictor of methadone maintenance outcomes in Chinese injection drug users.
abstract: This paper's design is descriptive and correlational based on retrospective self-report survey data collected in Kunming city, China. The study investigated the difference between a group of Chinese HIV positive (N=36) and negative (N=131) opioid dependent adults maintained on methadone treatment. Comparisons were based on their quality of life (QOL), methadone treatment adherence, adverse symptom occurrence related to methadone treatment, and HIV-related behavior changes. No significant differences were found between the two groups in age, methadone maintenance dose, methadone adherence, sex desire, and drug craving level. Participants who were HIV positive reported significantly lower scores on physical health and total health-related qualify of life. They also reported greater engagement in injection related risk behavior before methadone treatment than those who tested HIV negative. For both groups, sexual and injection risk behavior significantly decreased following initiation of methadone treatment. A regression model revealed that those infected with HIV, associated significantly with higher likelihood of reporting constipation and lack of appetite, and higher frequency of reporting abdominal pain and nausea than HIV negative patients. The primary implication of these findings is that HIV positive persons in methadone treatment may require more focused services to meet their special HIV care and substance treatment needs.
authors.affiliation: Community Health Systems, University of California, San Francisco, CA, USA. lin.zhao@ucsf.edu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhao
authors.forename: William L
authors.initials: WL
authors.lastname: Holzemer
authors.forename: Mallory
authors.initials: M
authors.lastname: Johnson
authors.forename: Jacqueline P
authors.initials: JP
authors.lastname: Tulsky
authors.forename: Carol D
authors.initials: CD
authors.lastname: Rose
mesh_terms: D000328:Adult; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007989:Libido; D008297:Male; D055118:Medication Adherence; D008691:Methadone / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009294:Narcotics / Q000009:adverse effects / Q000627:therapeutic use*; D058850:Opiate Substitution Treatment / Q000009:adverse effects / Q000379:methods*; D011788:Quality of Life; D012189:Retrospective Studies; D012309:Risk-Taking; D057566:Self Report; D012725:Sexual Behavior; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000534:rehabilitation*; D055815:Young Adult
chemical_list: D009294:Narcotics; D008691:Methadone