title: Indication for relumpectomy--a useful scoring system in cases of invasive breast cancer.
abstract: OBJECTIVE
  In two-thirds of breast cancer patients undergoing reoperation no residual tumor will be found. A scoring system for selection of patients who might benefit from relumpectomy is proposed.
  
  
  METHODS
  This study is based on 293 patients with invasive breast cancer undergoing reoperation due to margins of <2 mm. Eighteen parameters were evaluated by univariate and multivariate stepwise logistic regression.
  
  
  RESULTS
  Univariate analysis identified nine parameters associated with a residual invasive tumor: surgical margins; lobular histological type; grade 3; multifocality; positive lymph modes; non-fine needle localization (FNL) versus FNL lumpectomy; vascular/lymphatic invasion; age <50 years; and tumor size ≥3 cm. Multivariate stepwise logistic regression study identified six out of nine parameters associated with a higher probability of finding a residual invasive tumor: margins <1 mm, multifocality, tumor size ≥3 cm, positive lymph nodes, age <50 years, and lumpectomy without previous FNL. Odds of these factors were used for scoring.
  
  
  CONCLUSIONS
  For patients with surgical margins <2 mm and a score of <4, the probability of finding a residual invasive tumor is 0%, while the probability of finding a microfocus of <2 mm of invasive carcinoma is 3.2% and of finding residual DCIS is up to 10%.
authors.affiliation: Division of Surgery, Assaf Harofeh Medical Center, Zerifin, Israel. ahalevi@asaf.health.gov.il
authors.forename: Ariel
authors.initials: A
authors.lastname: Halevy
authors.forename: Ron
authors.initials: R
authors.lastname: Lavy
authors.forename: Itzhak
authors.initials: I
authors.lastname: Pappo
authors.forename: Tima
authors.initials: T
authors.lastname: Davidson
authors.forename: Ruth
authors.initials: R
authors.lastname: Gold-Deutch
authors.forename: Igor
authors.initials: I
authors.lastname: Jeroukhimov
authors.forename: Zahar
authors.initials: Z
authors.lastname: Shapira
authors.forename: Ilan
authors.initials: I
authors.lastname: Wassermann
authors.forename: Judith
authors.initials: J
authors.lastname: Sandbank
authors.forename: Bar
authors.initials: B
authors.lastname: Chikman
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery*; D018275:Carcinoma, Lobular / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008408:Mastectomy; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate