title: Proinflammatory cytokines in peritonitis.
abstract: BACKGROUND
  We performed this study with the purpose of revealing different aspects of the systemic inflammatory response syndrome in peritonitis.
  
  
  OBJECTIVE
  The aim of the presentation was to make a research on some of the immune response mediators in secondary peritonitis and to observe their capacity to anticipate the evolution towards septic complications.
  
  
  RESULTS
  We have undertaken a study on a group of 100 patients with acute diffuse peritonitis, between 2009 and 2011, in which we have accomplished the dosage of IL-1 beta, IL-6 and TNF alpha cytokines in the serum of patients, in dynamics, for 7 days by using the Elisa method. Subsequently, we have compared the results to the ones of a control group. The data obtained indicated high levels of proinflammatory cytokines in the patients who subsequently suffered an unfavorable evolution towards septic complications.
  
  
  CONCLUSIONS
  The study of IL-1 beta, IL-6 and TNF alpha blood dynamics, offers valuable information about the severity of a systemic inflammatory response syndrome in peritonitis. They can be valuable biomarkers in establishing the unfavorable evolution of patients, helping the physician to establish a sustained and specific treatment, even from the early phases of the illness.
authors.affiliation: Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. doctorcristianbadiu@yahoo.com
authors.forename: D C
authors.initials: DC
authors.lastname: Badiu
authors.forename: V
authors.initials: V
authors.lastname: Paunescu
authors.forename: A
authors.initials: A
authors.lastname: Aungurenci
authors.forename: D
authors.initials: D
authors.lastname: Pasarica
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016207:Cytokines / Q000097:blood*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D010538:Peritonitis / Q000097:blood* / Q000150:complications / Q000276:immunology* / Q000601:surgery; D018805:Sepsis / Q000097:blood / Q000150:complications / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D016207:Cytokines; C508585:IL1B protein, human; C508600:IL6 protein, human; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha