title: Ultrasound evaluation of prognosis in fetuses with posterior urethral valves.
abstract: OBJECTIVE
  The aim of this study was to evaluate the ability of prenatal ultrasound markers to predict postnatal renal prognosis in fetuses with posterior urethral valves.
  
  
  METHODS
  Medical files on fetuses with prenatal diagnosis of posterior urethral valves from 2000 to 2006 were reviewed retrospectively. Data from prenatal follow-up included gestational age at diagnosis, ultrasound renal parenchyma evaluation, and presence and time of oligohydramnios onset. Prenatal parameters studied were correlated to postnatal renal function.
  
  
  RESULTS
  Thirty-one male fetuses were included. Six pregnancies were terminated. Of the remaining 25 pregnancies that were continued, 4 children had abnormal creatine and 21 normal creatinine levels at follow-up. Presence and time of oligohydramnios onset did not differ between groups (P = .43). Ultrasound detected bilateral renal abnormalities in 3 fetuses (75%) with altered renal function, and 10 fetuses (55%) with normal creatinine, at follow-up.
  
  
  CONCLUSIONS
  None of the ultrasound parameters evaluated were able to reliably predict postnatal renal function.
authors.affiliation: Maternité. Hôpital Necker-Enfants Malades, APHP, Université Paris Descartes, France. lisbernardes@usp.br
authors.forename: Lisandra Stein
authors.initials: LS
authors.lastname: Bernardes
authors.forename: Remi
authors.initials: R
authors.lastname: Salomon
authors.forename: Gunnar
authors.initials: G
authors.lastname: Aksnes
authors.forename: Stephen
authors.initials: S
authors.lastname: Lortat-Jacob
authors.forename: Alexandra
authors.initials: A
authors.lastname: Benachi
mesh_terms: D000025:Abortion, Eugenic; D003404:Creatinine / Q000097:blood; D005260:Female; D046128:Fetal Therapies; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007668:Kidney / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D016104:Oligohydramnios / Q000453:epidemiology / Q000209:etiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors; D016216:Ultrasonography, Prenatal; D014521:Urethra / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000196:embryology; D001613:beta 2-Microglobulin / Q000097:blood / Q000652:urine
chemical_list: D001613:beta 2-Microglobulin; D003404:Creatinine