title: New polyacetylene glucosides from the florets of Carthamus tinctorius and their weak anti-inflammatory activities.
abstract: Eight new linear polyacetylene glucosides (1-8), containing two C(10)-, one C(13)- and five C(14)-acetylenes, together with three known polyacetylenes (9-11) were isolated from the florets of Carthamus tinctorius L. Their structures were elucidated by means of spectroscopic methods and chemical evidence. The absolute configurations of compounds 3-9 were confirmed by Snatzke and Gerards's method, observing the induced circular dichroism after addition of dirhodium tetrakis (trifluoroacetate) [Rh(2)(OCOCF(3))(4)] in CHCl(3). All the isolated compounds (1-11) were also tested for inhibitory activities against LPS-induced NO production in murine macrophages and just showed weak activities at concentrations of 1×10(-5)M.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, People's Repulic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.forename: Yi
authors.initials: Y
authors.lastname: Shen
authors.forename: Jian-Shuang
authors.initials: JS
authors.lastname: Jiang
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Yang
authors.forename: Zi-Ming
authors.initials: ZM
authors.lastname: Feng
authors.forename: Pei-Cheng
authors.initials: PC
authors.lastname: Zhang
authors.forename: Shao-Peng
authors.initials: SP
authors.lastname: Yuan
authors.forename: Qi
authors.initials: Q
authors.lastname: Hou
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D031187:Carthamus tinctorius / Q000737:chemistry*; D002478:Cells, Cultured; D035264:Flowers / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D053279:Polyynes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D005960:Glucosides; D053279:Polyynes