title: Synthesis of the macrocyclic core of leiodermatolide.
abstract: The macrocyclic core (2) of the marine macrolide leiodermatolide (1) has been synthesized in 19 steps through a convergent strategy exploiting boron aldol methodology to install the requisite stereochemistry and a selective Stille coupling reaction for controlled fragment assembly, followed by a Yamaguchi macrolactonization and carbamate introduction at the C9-OH.
authors.affiliation: University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK. ip100@cam.ac.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Paterson
authors.forename: Tanya
authors.initials: T
authors.lastname: Paquet
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Dalby
mesh_terms: D018942:Macrolides / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D018942:Macrolides; C559222:leiodermatolide