title: A new synthesis of 2-chloro-2'-deoxyadenosine (Cladribine), CdA).
abstract: A new efficient route for the synthesis of 2-chloro-2';-deoxyadenosine (Cladribine), CdA) has been developed. The key step of this method was selective deprotection of the acetyl group at the 2' position; the 3', 5' acetyl groups were not affected. This can be accomplished efficiently with hydroxylamine hydrochloride and sodium acetate in pyridine. The 2' hydroxyl group was removed by the Barton-McCombie reaction. Using this strategy, CdA was prepared in five steps and 31.0% yields.
authors.affiliation: Department of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang City, Henan Province, PR China.
authors.forename: Shaohong
authors.initials: S
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Yao
authors.forename: Gairong
authors.initials: G
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D017338:Cladribine / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D017338:Cladribine