title: Sharp curvature of frontal lobe white matter pathways in children with autism spectrum disorders: tract-based morphometry analysis.
abstract: OBJECTIVE
  Because we had previously observed geometric changes of frontal lobe association pathways in children with ASD, in the present study we analyzed the curvature of these white matter pathways by using an objective TBM analysis.
  
  
  METHODS
  Diffusion tensor imaging was performed in 32 children with ASD and 14 children with typical development. Curvature, FA, AD, and RD of bilateral AF, UF, and gCC were investigated by using the TBM group analysis assessed by P(FDR) for multiple comparisons.
  
  
  RESULTS
  Significantly higher curvatures were found in children with ASD, especially at the parietotemporal junction for AF (left, P(FDR) < .001; right, P(FDR) < .01), at the frontotemporal junction for UF (left, P(FDR) < .005; right, P(FDR) < .03), and at the midline of the gCC (P(FDR) < .0001). RD was significantly higher in children with ASD at the same bending regions of AF (left, P(FDR) < .03, right, P(FDR) < .02), UF (left, P(FDR) < .04), and gCC (P(FDR) < .01).
  
  
  CONCLUSIONS
  Higher curvature and curvature-dependent RD changes in children with ASD may be the result of higher attenuation of thinner axons in these frontal lobe tracts.
authors.affiliation: Carman and Ann Adams Departments of Pediatrics, Wayne State University School of Medicine, MI, USA. jeongwon@pet.wayne.edu
authors.forename: J-W
authors.initials: JW
authors.lastname: Jeong
authors.forename: A K
authors.initials: AK
authors.lastname: Kumar
authors.forename: S K
authors.initials: SK
authors.lastname: Sundaram
authors.forename: H T
authors.initials: HT
authors.lastname: Chugani
authors.forename: D C
authors.initials: DC
authors.lastname: Chugani
mesh_terms: D001931:Brain Mapping / Q000379:methods; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000473:pathology*; D002675:Child, Preschool; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009434:Neural Pathways / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology