title: Associations between spontaneous movement abnormalities and psychotic-like experiences in the general population.
abstract: An accumulating body of literature supports the notion that psychotic-like experiences (PLEs) may occur as a continuous phenotype. However, researchers are still working to determine if these events accompany an underlying continuum of neurobiological vulnerability as well. Within this context, it is notable that spontaneous dyskinetic movements are linked to specific pathogenic factors underlying schizophrenia, but to date there has been little research directed towards determining whether these events are associated with PLEs. In this study, 119 individuals were assessed for PLEs and administered with a sensitive instrumental test of upper extremity dyskinesia. Present findings suggest a relationship between subtle dyskinesia and PLEs in the general population, and provide a new perspective of the psychosis continuum by indicating that basal ganglia pathology may also underlie PLEs at the non-clinical end of this spectrum.
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado at Boulder, Colorado 80309-0345, United States.
authors.forename: Vijay A
authors.initials: VA
authors.lastname: Mittal
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Dean
authors.forename: Andrea
authors.initials: A
authors.lastname: Pelletier
authors.forename: Michael
authors.initials: M
authors.lastname: Caligiuri
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D008297:Male; D009069:Movement Disorders / Q000453:epidemiology*; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000523:psychology; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult