title: Bioactive xenicane diterpenoids from the Taiwanese soft coral Asterospicularia laurae.
abstract: Chemical investigation of the Taiwanese soft coral Asterospicularia laurae has led to the isolation of three new xenicane diterpenoids, named asterolaurins K-M (1-3, resp.). Their chemical structures were determined through extensive spectroscopic analyses ((1) H- and (13) C-NMR, (1) H,(1) H-COSY, HMBC, and NOESY). Compound 2 exhibited cytotoxic activity against HEp-2, Daoy, MCF-7, and WiDr tumor cells.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan, Republic of China.
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Lin
authors.forename: Ahmed
authors.initials: A
authors.lastname: Eid Fazary
authors.forename: Chung-Hsiung
authors.initials: CH
authors.lastname: Chen
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D013624:Taiwan
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes