title: Downregulation of Foxe1 by HR suppresses Msx1 expression in the hair follicles of Hr(Hp) mice.
abstract: Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. In turn, Msx1 expression was downregulated contingent on Foxe1 downregulation in skin and keratinocytes. We also found that expression of Sfrp1 was also correlated with that of Foxe1. Further investigation of the mechanisms involved in the transcriptional regulation of these genes will facilitate our understanding of the relationship among genes involved in hair follicle morphogenesis and cycling.
authors.affiliation: Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jee-Hyun
authors.initials: JH
authors.lastname: Choi
authors.forename: Byong-Kyu
authors.initials: BK
authors.lastname: Kim
authors.forename: Jeong-Ki
authors.initials: JK
authors.lastname: Kim
authors.forename: Hwa-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Park
authors.forename: Sungjoo Kim
authors.initials: SK
authors.lastname: Yoon
mesh_terms: D000818:Animals; D015536:Down-Regulation / Q000235:genetics*; D051858:Forkhead Transcription Factors / Q000235:genetics* / Q000378:metabolism; D018859:Hair Follicle / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism; D051957:MSX1 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008812:Mice, Hairless; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D051858:Forkhead Transcription Factors; D036341:Intercellular Signaling Peptides and Proteins; D051957:MSX1 Transcription Factor; D008565:Membrane Proteins; D014157:Transcription Factors; C472789:Foxe1 protein, mouse; C484084:Msx1 protein, mouse; C485539:Sfrp1 protein, mouse; D000094742:Secreted Frizzled-Related Proteins; C088661:hr protein, mouse