title: Bioactivity of the conjugation of green-emitting CdTe quantum dots with a carborane complex.
abstract: In this report, we describe the effect of conjugating o-carborane-C(1)C(2)-dicarboxylic acid (o-C2B10H10-C2O4H2, denoted as Cbac2) to cadmium telluride quantum dots (CdTe QDs) capped with cysteamine on the photophysics and cytotoxicity of the QDs. Cbac2 quenches the fluorescence intensity and induces a red shift of the fluorescence emission peak. Meanwhile, studies with a real time cell electronic sensing (RT-CES) system and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl (MTT) assay indicate that the combination of the carborane carboxylic acid derivative Cbac2 with relevant QDs can efficiently improve the inhibition efficiency for target cancer cells when compared with a single ligand or the CdTe QDs alone. This study raises the possibility for the labeling of the important pharmacophore with QDs and the design of new promising anticancer agents containing the carborane pharmacophores for cancer therapy.
authors.affiliation: State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing 210096, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Wu
authors.forename: Lixin
authors.initials: L
authors.lastname: Shi
authors.forename: Qingning
authors.initials: Q
authors.lastname: Li
authors.forename: Juan
authors.initials: J
authors.lastname: Zhao
authors.forename: Matthias
authors.initials: M
authors.lastname: Selke
authors.forename: Hong
authors.initials: H
authors.lastname: Yan
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wang
mesh_terms: D001880:Boranes / Q000627:therapeutic use*; D019187:Cadmium Compounds / Q000737:chemistry*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology*; D045744:Cell Line, Tumor; D003116:Color; D006801:Humans; D008029:Lighting / Q000295:instrumentation; D008856:Microscopy, Fluorescence / Q000379:methods*; D053769:Nanocapsules / Q000737:chemistry*; D045663:Quantum Dots; D013691:Tellurium / Q000737:chemistry*
chemical_list: D001880:Boranes; D019187:Cadmium Compounds; D053769:Nanocapsules; D013691:Tellurium; C028337:cadmium telluride