title: Localized reentry within the left atrial appendage: arrhythmogenic role in patients undergoing ablation of persistent atrial fibrillation.
abstract: BACKGROUND
  Left atrial appendage (LAA) is implicated in maintenance of atrial fibrillation (AF) and atrial tachycardia (AT) associated with persistent AF (PsAF) ablation, although little is known about the incidence and mechanism of LAA AT.
  
  
  OBJECTIVE
  The purpose of this study was to characterize LAA ATs associated with PsAF ablation.
  
  
  METHODS
  In 74 consecutive patients undergoing stepwise PsAF ablation, 142 ATs were encountered during index and repeat procedures. Out of 78 focal-source ATs diagnosed by activation and entrainment mapping, 15 (19%) arose from the base of LAA. Using a 20-pole catheter, high-density maps were constructed (n = 10; age 57 ± 6 years) to characterize the mechanism of LAA-AT. The LAA orifice was divided into the posterior ridge and anterior-superior and inferior segments to characterize the location of AT.
  
  
  RESULTS
  Fifteen patients with LAA AT had symptomatic PsAF for 17 ± 15 months before ablation. LAA AT (cycle length [CL] 283 ± 30 ms) occurred during the index procedure in four and after 9 ± 7 months in 11 patients. We could map 89% ± 8% AT CLs locally with favorable entrainment from within the LAA, which is suggestive of localized reentry with centrifugal atrial activation. ATs were localized to inferior segment (n = 4), anterior-superior segment (n = 5), and posterior ridge (n = 6) with 1:1 conduction to the atria. Ablation targeting long fractionated or mid-diastolic electrogram within the LAA resulted in tachycardia termination. Postablation, selective contrast radiography demonstrated atrial synchronous LAA contraction in all but one patient. At 18 ± 7 months, 13/15 (87%) patients remained in sinus rhythm without antiarrhythmic drugs.
  
  
  CONCLUSIONS
  LAA is an important source of localized reentrant AT in patients with PsAF at index and repeat ablation procedures. Ablation targeting the site with long fractionated or mid-diastolic LAA electrogram is highly effective in acute and medium-term elimination of the arrhythmia.
authors.affiliation: Hôpital Cardiologique du Haut-Lévêque, Bordeaux, France. meleze.hocini@chu-bordeaux.fr
authors.forename: Mélèze
authors.initials: M
authors.lastname: Hocini
authors.forename: Ashok J
authors.initials: AJ
authors.lastname: Shah
authors.forename: Isabelle
authors.initials: I
authors.lastname: Nault
authors.forename: Prashanthan
authors.initials: P
authors.lastname: Sanders
authors.forename: Matthew
authors.initials: M
authors.lastname: Wright
authors.forename: Sanjiv M
authors.initials: SM
authors.lastname: Narayan
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Pierre
authors.initials: P
authors.lastname: Jaïs
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Matsuo
authors.forename: Sébastien
authors.initials: S
authors.lastname: Knecht
authors.forename: Frédéric
authors.initials: F
authors.lastname: Sacher
authors.forename: Kang-Teng
authors.initials: KT
authors.lastname: Lim
authors.forename: Jacques
authors.initials: J
authors.lastname: Clémenty
authors.forename: Michel
authors.initials: M
authors.lastname: Haïssaguerre
mesh_terms: D020517:Atrial Appendage / Q000503:physiopathology / Q000601:surgery*; D001281:Atrial Fibrillation / Q000503:physiopathology / Q000601:surgery*; D017115:Catheter Ablation; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome