title: Structural mass spectrometry of proteins using hydroxyl radical based protein footprinting.
abstract: Structural MS is a rapidly growing field with many applications in basic research and pharmaceutical drug development. In this feature article the overall technology is described and several examples of how hydroxyl radical based footprinting MS can be used to map interfaces, evaluate protein structure, and identify ligand dependent conformational changes in proteins are described.
authors.affiliation: Center for Proteomics & Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.
authors.forename: Liwen
authors.initials: L
authors.lastname: Wang
authors.forename: Mark R
authors.initials: MR
authors.lastname: Chance
mesh_terms: D017665:Hydroxyl Radical / Q000737:chemistry*; D013058:Mass Spectrometry; D008958:Models, Molecular; D011487:Protein Conformation; D023302:Protein Footprinting; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins; D017665:Hydroxyl Radical