title: Moving toward personalized cell-based interventions for adrenal cortical disorders: part 1--Adrenal development and function, and roles of transcription factors and signaling proteins.
abstract: Transdifferentiation of an individual's own cells into functional differentiated cells to replace an organ's lost function would be a personalized approach to therapeutics. In this two part series, we will describe the progress toward establishing functional transdifferentiated adrenal cortical cells. In this article (Part 1), we describe adrenal development and function, and discuss genes involved in these processess and selected for use in our pilot studies of transdifferentiation that are presented in the second article (Part 2).
authors.affiliation: Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Jaime K
authors.initials: JK
authors.lastname: Mazilu
authors.forename: Edward R B
authors.initials: ER
authors.lastname: McCabe
mesh_terms: D000303:Adrenal Cortex Diseases / Q000196:embryology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D000311:Adrenal Glands / Q000196:embryology* / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D006801:Humans; D057285:Precision Medicine; D015398:Signal Transduction; D013256:Steroids / Q000096:biosynthesis; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D013256:Steroids; D014157:Transcription Factors