title: Microwave-assisted domino access to C2-chain functionalized furans from tertiary propargyl vinyl ethers.
abstract: Tertiary propargyl vinyl ethers armed with an electron-withdrawing group (amide or ester) at the tertiary propargylic position have been efficiently transformed into trisubstituted C(2)-chain functionalized furans. The metal-free domino transformation involves a microwave-assisted tandem [3,3]-propargyl Claisen rearrangement/5-exo-dig O-cyclization reaction. The manifold can be performed in a one-pot fashion from the primary components (1,2-ketoester/1,2-ketoamide or tertiary propargyl alcohols).
authors.affiliation: Departamento de Química Biológica y Biotecnología, Instituto de Productos Naturales y Agrobiología , CSIC, Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain. dtejedor@ipna.csic.es
authors.forename: David
authors.initials: D
authors.lastname: Tejedor
authors.forename: Leandro
authors.initials: L
authors.lastname: Cotos
authors.forename: Fernando
authors.initials: F
authors.lastname: García-Tellado
mesh_terms: D005663:Furans / Q000138:chemical synthesis*; D008872:Microwaves; D015394:Molecular Structure; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D005663:Furans; D014753:Vinyl Compounds; C100195:vinyl ether