title: Formation and stability of synaptic receptor domains.
abstract: Neurotransmitter receptor molecules, concentrated in postsynaptic domains along with scaffold and a number of other molecules, are key regulators of signal transmission across synapses. Combining experiment and theory, we develop a quantitative description of synaptic receptor domains in terms of a reaction-diffusion model. We show that interactions between only receptors and scaffolds, together with the rapid diffusion of receptors on the cell membrane, are sufficient for the formation and stable characteristic size of synaptic receptor domains. Our work reconciles long-term stability of synaptic receptor domains with rapid turnover and diffusion of individual receptors, and suggests novel mechanisms for a form of short-term, postsynaptic plasticity.
authors.affiliation: Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA.
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Haselwandter
authors.forename: Martino
authors.initials: M
authors.lastname: Calamai
authors.forename: Mehran
authors.initials: M
authors.lastname: Kardar
authors.forename: Antoine
authors.initials: A
authors.lastname: Triller
authors.forename: Rava Azeredo
authors.initials: RA
authors.lastname: da Silveira
mesh_terms: D000818:Animals; D019556:COS Cells; D018929:Cell Culture Techniques; D002462:Cell Membrane / Q000378:metabolism*; D002522:Chlorocebus aethiops; D004058:Diffusion; D008954:Models, Biological; D009473:Neuronal Plasticity; D018009:Receptors, Glycine / Q000737:chemistry* / Q000378:metabolism*; D059010:Single-Cell Analysis / Q000379:methods*; D013569:Synapses / Q000378:metabolism*
chemical_list: D018009:Receptors, Glycine