title: [Genetics of osteoporosis].
abstract: Osteoporosis is characterized by low bone mineral density (BMD) and microarchitectural deterioration of bone tissue, with a consequent increase in the fragility of bones and susceptibility to fractures. Over the last five years, genome-wide association studies (GWAS) have identified the single-nucleotide polymorphisms(SNPs) associated with osteoporosis, BMD and other determinants of fracture risk. These SNPs were mapped close to or within the genes, such as LRP5, RANKL, SOST and ESR1. In the future, the novel important bone loss susceptibility genes may be uncovered by the GWAS.
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Urano
mesh_terms: D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics*; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D008297:Male; D010024:Osteoporosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5