title: Two acid sorbicillin analogues from saline lands-derived fungus Trichoderma sp.
abstract: Two new acid sorbicillin analogues, (E)-6-(2,4-dihydroxyl-5-methylphenyl)-6-oxo-2-hexenoic acid (1) and 6-(2,4-dihydroxyl-5-methylphenyl)-6-oxohexanoic acid (2), together with 12 known compounds, were isolated from a saline lands-derived fungus Trichoderma sp. The structures of the new compounds were established by interpretation of their spectroscopic data. Their cytotoxic effects on P388 and HL-60 cell lines were preliminarily evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) method. Furthermore, the new compounds exhibited weak radical scavenging activity against DPPH (1,1-diphenyl-2-picrylhydrazyl).
authors.affiliation: Department of Chemistry, Binzhou Medical College, Shandong, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Ma
authors.forename: Weizhong
authors.initials: W
authors.lastname: Liu
authors.forename: Yuling
authors.initials: Y
authors.lastname: Huang
authors.forename: Xianguo
authors.initials: X
authors.lastname: Rong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D014242:Trichoderma / Q000378:metabolism*
chemical_list: C567942:(E)-6-(2,4-dihydroxyl-5-methylphenyl)-6-oxo-2-hexenoic acid; C567941:6-(2,4-dihydroxyl-5-methylphenyl)-6-oxohexanoic acid; D000970:Antineoplastic Agents; D016166:Free Radical Scavengers; D012118:Resorcinols; C473616:sorbicillin