title: Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR.
abstract: The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of receptor endocytosis. However, the identities of the kinases involved in this process remained largely unknown until recently. This paper discusses advances in our knowledge of the important role played by protein phosphorylation in the regulation of the endocytic machinery and how phosphorylation controls the coated vesicle cycle.
authors.affiliation: Bordeaux Cardiothoracic Research Center, Bordeaux University, 146, Léo-Saignat, 33076 Bordeaux, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Delom
authors.forename: Delphine
authors.initials: D
authors.lastname: Fessart