title: Risk of significant gynaecological pathology in women with glandular neoplasia on cervical cytology.
abstract: OBJECTIVE
  To review the risk of pre-invasive and invasive gynaecological pathology in women referred with cervical cytology reporting ?glandular neoplasia.
  
  
  METHODS
  Review of the case notes of all women referred with cervical cytology reported as ?glandular neoplasia between January 1999 and December 2008 at two UK hospitals: Portsmouth Hospitals NHS Trust and Queen Mary's Hospital Sidcup. The category of 'borderline nuclear change in endocervical cells', result code 8 according to the national health service cancer screening programme (NHSCSP), was excluded from the study.
  
  
  RESULTS
  A total of 200 women were identified using the hospitals' pathology computer systems. Invasive carcinoma was found in 48 women (24%): 28 endocervical adenocarcinomas, eight squamous cell carcinomas (SCC), ten endometrial and two ovarian adenocarcinomas. Pre-invasive neoplasia was found in 115 (57.5%), including 14 cervical glandular intraepithelial neoplasia (CGIN), 31 cervical intraepithelial neoplasia (CIN) grade 2/3 and 70 concomitant CGIN and CIN2/3. CIN1/HPV was found in 25, simple endometrial hyperplasia in three and no histological abnormality in three. Thirty-four (70.8%) of 48 invasive carcinomas (of which 23 were endocervical adenocarcinomas) were in asymptomatic women investigated for abnormal cytology. Fourteen of 34 (41.4%) of those with ?glandular neoplasia thought to be endometrial were CGIN or CIN2/3. Colposcopic appearances were normal in 47.6% of women with pure cervical glandular neoplasia (adenocarcinoma or CGIN) compared with 12.8% with squamous cell lesions (CIN2/3 or SCC): P = 0.0001. Thus, colposcopy was more sensitive for detecting squamous cell abnormalities than their glandular counterparts. Although cervical adenocarcinomas are less amenable to prevention by screening than cervical SCC, in our study cervical cytology predominantly detected these abnormalities at their early asymptomatic stages.
  
  
  CONCLUSIONS
  At least CIN2 was found in 81.5% in women referred with cervical cytology reporting ?glandular neoplasia. A thorough evaluation of the whole genital tract is needed if colposcopy is negative.
authors.affiliation: Department of Gynaecological Oncology, Portsmouth Hospitals NHS Trust, Portsmouth, UK. astalaat@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Talaat
authors.forename: D
authors.initials: D
authors.lastname: Brinkmann
authors.forename: J
authors.initials: J
authors.lastname: Dhundee
authors.forename: Y
authors.initials: Y
authors.lastname: Hana
authors.forename: J
authors.initials: J
authors.lastname: Bevan
authors.forename: R
authors.initials: R
authors.lastname: Irvine
authors.forename: S
authors.initials: S
authors.lastname: Bailey
authors.forename: R
authors.initials: R
authors.lastname: Woolas
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology*; D003127:Colposcopy; D003584:Cytological Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis / Q000473:pathology*; D012307:Risk Factors; D006113:United Kingdom; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology*