title: A patient death attributable to implant-related primary anaplastic large cell lymphoma of the breast.
abstract: Implant-related primary anaplastic large cell lymphoma (ALCL) of the breast is a rare clinical entity. With increasing attention being paid to this disease, most cases reported to date in the literature have demonstrated indolent clinical courses responsive to explantation, capsulectomy, chemotherapy, and/or radiotherapy. The authors describe a case of bilateral implant-related primary ALCL of the breast that proved refractory to both standard and aggressive interventions, ultimately resulting in patient death secondary to disease progression. The authors situate this case in the context of the current state of knowledge regarding implant-related primary ALCL of the breast and suggest that this entity is generally, but not universally, indolent in nature.
  
  
  METHODS
  Risk, V.
authors.affiliation: Jamaica Plain and Boston, Mass. From the Division of Plastic Surgery and the Department of Pathology, Brigham and Women's Hospital; the Division of Hematology/Oncology, Dana Farber Cancer Institute; and the Division of Hematology/Oncology, Massachusetts General Hospital.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Carty
authors.forename: Julian J
authors.initials: JJ
authors.lastname: Pribaz
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Antin
authors.forename: Elgida R
authors.initials: ER
authors.lastname: Volpicelli
authors.forename: Christiana E
authors.initials: CE
authors.lastname: Toomey
authors.forename: Evan A
authors.initials: EA
authors.lastname: Farkash
authors.forename: Ephraim P
authors.initials: EP
authors.lastname: Hochberg
mesh_terms: D001940:Breast / Q000473:pathology; D018427:Breast Implants / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D002423:Cause of Death; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D011183:Postoperative Complications / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D011475:Prosthesis Failure; D012086:Reoperation; D020034:Silicone Gels
chemical_list: D020034:Silicone Gels