title: PPARG gene promoter polymorphism is associated with non-traumatic hip fracture risk in the elderly Slovenian population: a pilot study.
abstract: OBJECTIVE
  Peroxisome proliferator-activated receptor γ (PPARγ), an essential transcription factor for adipogenesis, has been implicated in pathogenesis of osteoporosis. The association of three single nucleotide polymorphisms in the PPARG gene with hip fracture risk, bone mineral density (BMD) and biochemical markers of bone turnover was investigated in the elderly.
  
  
  METHODS
  Six hundred sixty-seven elderly Slovenians were genotyped for SNPs rs12497191, rs1801282 and rs3856806. BMD and biochemical markers of bone turnover were measured. Haplotypes ACC, AGT and GCC, defined by rs12497191, rs1801282 and rs3856806 were assigned. Influence of genotype on fracture risk was assessed in 72 non-traumatic hip fracture cases and 272 controls.
  
  
  RESULTS
  The rs12497191 G allele alone or in haplotype was associated with lower risk of non-traumatic hip fracture and higher serum receptor activator of nuclear factor κB ligand.
  
  
  CONCLUSIONS
  The rs12497191 genotype could contribute to the incidence of non-traumatic hip fractures in the elderly.
authors.affiliation: University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Aškerčeva cesta 7, SI 1000, Ljubljana, Slovenia.
authors.forename: Jana
authors.initials: J
authors.lastname: Dragojevič
authors.affiliation: University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Aškerčeva cesta 7, SI 1000, Ljubljana, Slovenia.
authors.forename: Barbara
authors.initials: B
authors.lastname: Ostanek
authors.affiliation: University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Aškerčeva cesta 7, SI 1000, Ljubljana, Slovenia.
authors.forename: Simona
authors.initials: S
authors.lastname: Mencej-Bedrač
authors.affiliation: General and Teaching Hospital Celje, Department of Traumatology, Oblakova ulica 5, SI 3000, Celje, Slovenia.
authors.forename: Radko
authors.initials: R
authors.lastname: Komadina
authors.affiliation: University Medical Centre Ljubljana, Department of Endocrinology, Diabetes and Metabolic Diseases, Zaloška cesta 7, SI 1000, Ljubljana, Slovenia.
authors.forename: Janez
authors.initials: J
authors.lastname: Preželj
authors.affiliation: University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Aškerčeva cesta 7, SI 1000, Ljubljana, Slovenia. Electronic address: janja.marc@ffa.uni-lj.si.
authors.forename: Janja
authors.initials: J
authors.lastname: Marc
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D015519:Bone Density; D016723:Bone Remodeling; D016022:Case-Control Studies; D005838:Genotype; D006239:Haplotypes; D006620:Hip Fractures / Q000235:genetics*; D006801:Humans; D047495:PPAR gamma / Q000235:genetics*; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D017524:Slovenia / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D047495:PPAR gamma