title: Living donor liver transplantation for acute liver failure in pediatric patients caused by the ingestion of fireworks containing yellow phosphorus.
abstract: Yellow phosphorus is a protoplasmic toxicant that targets the liver. The ingestion of fireworks containing yellow phosphorus, either by children who accidentally consume them or by adults who are attempting suicide, often results in death due to acute liver failure (ALF). We present the outcomes of 10 children who ingested fireworks containing yellow phosphorus. There were 6 boys and 4 girls, and their ages ranged from 21 to 60 months. One patient remained stable without liver complications and was discharged. Three patients died of hepatorenal failure and cardiovascular collapse, and living donor liver transplantation (LDLT) was performed for 6 patients. The patients had grade II or III encephalopathy, a mean alanine aminotransferase level of 1148.2 IU/L, a mean aspartate aminotransferase level of 1437.5 IU/L, a mean total bilirubin level of 6.9 mg/dL, a mean international normalized ratio of 6.6, a mean Pediatric End-Stage Liver Disease score of 33.7, and a mean Child-Pugh score of 11.3. Postoperatively, 2 patients had persistent encephalopathy and died on the second or third postoperative day, and 1 patient died of cardiac arrest on the first postoperative day despite a well-functioning graft. The other 3 patients were still alive at a mean of 204 days. In conclusion, the ingestion of fireworks containing yellow phosphorus causes ALF with a high mortality rate. When signs of irreversible ALF are detected, emergency LDLT should be considered as a lifesaving procedure; however, if yellow phosphorus toxicity affects both the brain and the heart in addition to the liver, the mortality rate remains very high despite liver transplantation.
authors.affiliation: Division of Liver Transplantation, Department of General Surgery, Inonu University Medical Faculty, Malatya, Turkey. drmustafaates@hotmail.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ates
authors.forename: Abuzer
authors.initials: A
authors.lastname: Dirican
authors.forename: Dincer
authors.initials: D
authors.lastname: Ozgor
authors.forename: Cemalettin
authors.initials: C
authors.lastname: Aydin
authors.forename: Burak
authors.initials: B
authors.lastname: Isik
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ara
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yilmaz
authors.forename: M
authors.initials: M
authors.lastname: Ayse Selimoglu
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Kayaalp
authors.forename: Sezai
authors.initials: S
authors.lastname: Yilmaz
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000601:surgery*; D002675:Child, Preschool; D053834:Explosive Agents / Q000506:poisoning; D005260:Female; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D010758:Phosphorus / Q000506:poisoning*; D014421:Turkey
chemical_list: D053834:Explosive Agents; D010758:Phosphorus