title: [Complete response in a patient with liver metastasis of esophageal squamous cell carcinoma treated with docetaxel].
abstract: On routine endoscopy a Type 2 tumor was found in the esophagogastric junction of a 74-year-old man. A histological diagnosis of squamous cell carcinoma was made based on a biopsy specimen, and lower esophagectomy and proximal gastrectomy were performed. The pathological diagnosis was pT3, N2, M0, pStage III. A low-dose FP treatment as adjuvant chemotherapy was given for only three weeks due to severe anorexia. A liver metastases measuring 22×24 mm in diameter at the s6 lesion was found with a CT examination a year and a half after the operation. A dose of 70 mg/m2 of docetaxel was given by intervenous infusion, and repeated every four weeks. Toxicities, grade 4 neutropenia and mild pneumonia associated with this chemotherapy regimen, were observed after five cycles. Therefore this treatment was discontinued. CT performed at that time showed a complete response (CR) and no more recurrences for six months. Docetaxel treatment is considered to be safe for outpatients and is one of the cures for metastatic esophageal cancer.
authors.affiliation: Dept. of Surgery, Oita Koseiren Tsurumi Hospital, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Noguchi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kubo
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Aizawa
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Harada
authors.forename: Shozo
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Noguchi
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D000077143:Docetaxel; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D043823:Taxoids / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D043823:Taxoids; D000077143:Docetaxel