title: [Therapeutic efficacy of Triazavirin, a novel Russian chemotherapeutic, against influenza virus A (H5N1)].
abstract: Therapeutic activity of Triazavirin against experimental influenza A was studied on albino mice intranazally infected with influenza virus A/Chicken/Kurgan/Russia/02/05 (H5N1) vs. reference drugs (Oseltamivir, Remantadin and Arbidol). The study showed that in a therapeutic dose of 1 mg/kg Triazavirin was efficient in protection of the animals from death. Its protective therapeutic efficacy (36.7+/-1.7%) was close to that of Oseltamivir (50.0+/-0.0%), comparable with that of Remantadin (38.3+/-1.7%) and higher than that of Arbidol (11.7+/-1.7%). During the whole observation period (up to the terminal phase) Triazavirin inhibited the influenza virus A accumulation in the lungs of the infected albino mice by more than 3 lg.
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Loginova
authors.forename: S V
authors.initials: SV
authors.lastname: Borisevich
authors.forename: V A
authors.initials: VA
authors.lastname: Maksimov
authors.forename: V P
authors.initials: VP
authors.lastname: Bondarev
authors.forename: S K
authors.initials: SK
authors.lastname: Kotovskaia
authors.forename: V L
authors.initials: VL
authors.lastname: Rusinov
authors.forename: V N
authors.initials: VN
authors.lastname: Charushin
authors.forename: O N
authors.initials: ON
authors.lastname: Chupakhin
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D008168:Lung / Q000821:virology; D051379:Mice; D012426:Russia; D014227:Triazines / Q000494:pharmacology*; D014230:Triazoles
chemical_list: D000998:Antiviral Agents; D001393:Azoles; D014227:Triazines; D014230:Triazoles; C539416:riamilovir