title: Cell division: aurora B illuminates a checkpoint pathway.
abstract: Separating mitotic error correction, chromosome biorientation and the spindle assembly checkpoint (SAC) is complicated by their interconnected relationships. New research finds that Aurora B kinase, which drives error correction and promotes biorientation, also directly regulates the SAC.
authors.affiliation: Biology Department, University of Massachusetts Amherst, Amherst, MA 01003, USA. tmaresca@bio.umass.edu
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Maresca
mesh_terms: D064107:Aurora Kinase B; D064127:Aurora Kinases; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D020090:Chromosome Segregation; D006801:Humans; D018386:Kinetochores / Q000502:physiology*; D008870:Microtubules / Q000187:drug effects; D008938:Mitosis; D015739:Nocodazole / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000502:physiology*; D050257:Tubulin Modulators / Q000494:pharmacology
chemical_list: D018797:Cell Cycle Proteins; D050257:Tubulin Modulators; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; D015739:Nocodazole