title: [The clinical application of hydrogen magnetic resonance spectroscopy combining with diffusion weight imaging in brain gliomas grading].
abstract: The present study was aimed to investigate the function of diffusion weight imaging (DWI) combining with magnetic resonance spectroscopy (MRS) in the grading of brain gliomas. 12 cases low grade and 17 cases high grade of brain gliomas patients were examined with DWI and MRS, with all tumors confirmed by pathology in advance. The apparent diffusion coefficient (ADC) values, their corresponding metabolite ratios of Cho/Cr, Cho/NAA and tumor cellularities of tumor solid enhanced parts were measured. The ratios of Cho/Cr and Cho/NAA and their corresponding ADC values had significant differences between their high and low grade gliomas values, respectively. The ADC values demonstrated a negative correlation with Cho/Cr, Cho/NAA, and a significant negative correlated with Cho/Cr. And the ADC values demonstrated strong negative correlations with tumor cellularities. DWI combining with MRS could provide more valuable information in evaluating gliomas grading.
authors.affiliation: Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Shengsheng
authors.initials: S
authors.lastname: Xu
authors.forename: Yu
authors.initials: Y
authors.lastname: Ouyang
authors.forename: Tianyou
authors.initials: T
authors.lastname: Luo
authors.forename: Yongming
authors.initials: Y
authors.lastname: Zeng
authors.forename: Xiangping
authors.initials: X
authors.lastname: Zhou
authors.forename: Jiahe
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D055815:Young Adult
chemical_list: D006859:Hydrogen