title: The efficacy of Ankaferd Blood Stopper in heparin-induced hemostatic abnormality in a rat epistaxis model.
abstract: OBJECTIVE
  To assess the in vivo hemostatic effect of Ankaferd Blood Stopper (ABS).
  
  
  METHODS
  An experimental study of an animal anterior epistaxis model.
  
  
  METHODS
  A tertiary care university hospital.
  
  
  METHODS
  Wistar rats were randomized into 4 groups of 7 each: group 1, control, no pretreatment, irrigated with saline; group 2, no pretreatment, irrigated with ABS; group 3, control, heparin pretreatment, irrigated with saline; and group 4, heparin pretreatment, irrigated with ABS. In all groups, a standardized rat epistaxis model was obtained by cutting the anterior nasal septal mucosa. To control bleeding, compressive dressings were placed after instilling 1 mL of either ABS or saline to the bleeding area. The hemostasis time and amount of nasal bleeding were measured in all groups to compare the treatments without and with ABS.
  
  
  RESULTS
  Without heparin pretreatment, ABS shortened the hemostasis time by 1.57 minutes (P = .003) and reduced the amount of the bleeding by 0.35 g (P = .006). With heparin pretreatment, ABS shortened the hemostasis time by 2.86 minutes and reduced the amount of the bleeding by 0.49 g (both P = .002).
  
  
  CONCLUSIONS
  ABS irrigation was more effective than saline irrigation for treating anterior epistaxis hemostasis in animals using a compressive dressing with or without heparin pretreatment.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Harran University, Faculty of Medicine, Sanliurfa, Turkey. iiynen@hotmail.com
authors.forename: Ismail
authors.initials: I
authors.lastname: Iynen
authors.forename: Ozgur
authors.initials: O
authors.lastname: Sogut
authors.forename: Rustu
authors.initials: R
authors.lastname: Kose
mesh_terms: D000818:Animals; D058128:Compression Bandages; D004844:Epistaxis / Q000628:therapy*; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use*; D006493:Heparin / Q000008:administration & dosage; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D007507:Therapeutic Irrigation; D013997:Time Factors
chemical_list: D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper; D006493:Heparin