title: Utility of head/abdomen circumference ratio in the evaluation of severe early-onset intrauterine growth restriction.
abstract: OBJECTIVE
  To determine whether the predominant phenotype of intrauterine growth restriction (IUGR) is symmetric or asymmetric in severe, early-onset disease due to placental insufficiency.
  
  
  METHODS
  We conducted a retrospective chart review of high-risk pregnant women with severe, early-onset IUGR who were delivering at < 33+0 weeks' gestation at Mount Sinai Hospital from 2001 to 2010. Ultrasound images were reviewed for fetal biometry, amniotic fluid volume, and uterine and umbilical Doppler flow studies within seven days of delivery, and the frequency of head circumference/abdominal circumference ratio ≥ 95th percentile for gestation was determined.
  
  
  RESULTS
  Sixty-two of 107 pregnancies (58%) with early-onset IUGR had an elevated HC/AC ratio (≥ 95th percentile), which was more than 10-fold greater than the expected proportion (P < 0.001). High rates of severe preeclampsia (53%), abnormal amniotic fluid (70%), and abnormal uterine artery Doppler studies (78%) indicated placental insufficiency.
  
  
  CONCLUSIONS
  Fetuses with severe placental IUGR in the second trimester are more likely to have an asymmetric phenotype. This is in contrast to the current belief that asymmetric IUGR is confined to third trimester IUGR.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount Sinai Hospital, University of Toronto Toronto ON.
authors.forename: Nihal Al
authors.initials: NA
authors.lastname: Riyami
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount Sinai Hospital, University of Toronto Toronto ON.
authors.forename: Melissa G
authors.initials: MG
authors.lastname: Walker
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount Sinai Hospital, University of Toronto Toronto ON.
authors.forename: Leslie K
authors.initials: LK
authors.lastname: Proctor
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount Sinai Hospital, University of Toronto Toronto ON.
authors.forename: Yoav
authors.initials: Y
authors.lastname: Yinon
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount Sinai Hospital, University of Toronto Toronto ON.
authors.forename: Rory C
authors.initials: RC
authors.lastname: Windrim
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount Sinai Hospital, University of Toronto Toronto ON.
authors.forename: John C P
authors.initials: JCP
authors.lastname: Kingdom
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging / Q000196:embryology*; D000328:Adult; D000886:Anthropometry; D002508:Cephalometry; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging* / Q000209:etiology; D005865:Gestational Age; D006801:Humans; D010927:Placental Insufficiency / Q000000981:diagnostic imaging; D011247:Pregnancy; D016216:Ultrasonography, Prenatal