title: Olfactory neuroblastoma in dogs and cats--a histological and immunohistochemical analysis.
abstract: Olfactory neuroblastoma (ONB) was identified in 13 dogs and nine cats. The tumours were subjected to microscopical examination and were graded using a human pathological grading system. In the canine and feline tumours there was more necrosis and higher mitotic activity (mitotic index and Ki67 labelling index) than reported in human ONB. Rosettes were a common feature of feline ONBs. A significant correlation was observed between the histological grade and the Ki67 labelling index. The histopathological diagnosis of ONB was confirmed immunohistochemically by demonstration of the neuronal marker neuron-specific enolase (NSE). Two other neuron-specific antibodies specific for microtubule-associated protein-2 (MAP-2) and neuronal nuclei antigen (NeuN) were evaluated. MAP-2 expression proved to have higher specificity than labelling for NSE. NeuN expression was less sensitive and of limited practical value.
authors.affiliation: Chair of General Pathology and Neuropathology, Institute of Veterinary Pathology, Ludwig-Maximilians University, Veterinärstr. 13, D-80539 Munich, Germany. K.Brosinski@access.uzh.ch
authors.forename: K
authors.initials: K
authors.lastname: Brosinski
authors.forename: D
authors.initials: D
authors.lastname: Janik
authors.forename: A
authors.initials: A
authors.lastname: Polkinghorne
authors.forename: W
authors.initials: W
authors.lastname: Von Bomhard
authors.forename: W
authors.initials: W
authors.lastname: Schmahl
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000378:metabolism / Q000473:pathology*; D002415:Cats; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D018304:Esthesioneuroblastoma, Olfactory / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008940:Mitotic Index; D009296:Nasal Cavity / Q000378:metabolism / Q000473:pathology; D009336:Necrosis / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D009669:Nose Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism
chemical_list: D008869:Microtubule-Associated Proteins; D010751:Phosphopyruvate Hydratase