title: Calcium influx, a new potential therapeutic target in the control of neutrophil-dependent inflammatory diseases in bovines.
abstract: Neutrophils are the first line of defense against pathogens in bovines; however, they are also one of the most aggressive cells during the inflammatory process, causing injury in surrounding tissues. At present, anti-inflammatory drugs are limited in acute diseases, such as pneumonia, mastitis and endometritis, because neutrophils are mostly insensitive. One of the earliest events during neutrophil activation is the increase in intracellular calcium concentration. The calcium movement is attributed to the release from intracellular stores and influx through the calcium channels in the plasma membrane, a process called store operated calcium entry (SOCE). Recently, several calcium influx blockers have been shown to have strong effects on bovine neutrophils, and this suggests that the manipulation of this pathway can be useful in the control of neutrophil functions during acute inflammatory processes. In this paper, we will review the role of calcium influx as a potential anti-inflammatory target and summarize the most recent evidences for this in bovine neutrophils.
authors.affiliation: Laboratory of Molecular Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Science, Universidad Austral de Chile, Valdivia, Chile. rburgos1@uach.cl
authors.forename: R A
authors.initials: RA
authors.lastname: Burgos
authors.forename: I
authors.initials: I
authors.lastname: Conejeros
authors.forename: M A
authors.initials: MA
authors.lastname: Hidalgo
authors.forename: D
authors.initials: D
authors.lastname: Werling
authors.forename: C
authors.initials: C
authors.lastname: Hermosilla
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000378:metabolism*; D015550:Cell Degranulation / Q000187:drug effects; D005260:Female; D006863:Hydrogen-Ion Concentration; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D008297:Male; D008954:Models, Biological; D018375:Neutrophil Activation / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D016897:Respiratory Burst / Q000187:drug effects