title: Population approaches/sparse data analysis for human variability in kinetics and dynamics.
abstract: The application of sparse data analysis techniques, otherwise known as the population approach, to the assessment of pharmacokinetic and pharmacodynamic variability is reviewed. Using software that has recently become available it is now possible to analyse heterogeneous, sparse data from a variety of clinical trials, particularly during drug development. Therefore the pharmacokinetics and pharmacodynamics of a drug can be studied in the target population and this information can be used to guide dosage for optimal therapeutic benefit.
authors.forename: L
authors.initials: L
authors.lastname: Aarons