title: Potential transmission of the cytogenetic toxic effects of methotrexate in the male germline cells of Swiss mice.
abstract: On testing the cytogenetic toxic effects of methotrexate, a widely prescribed antineoplastic drug, in the male germline cells of Swiss mice, it was found highly clastogenic to the spermatogonial cells at 24-h post-treatment after a single intraperitoneal exposure. The occurrence of significant percentages of aberrant primary spermatocytes with atypical bivalents at week 4 post-treatment and a little higher percentages of sperm with abnormal morphology at week 8 post-treatment indicated the potential transmission of the induced cytogenetic toxic effects of methotrexate from spermatogonia to sperm in the male germline cells of Swiss mice.
authors.affiliation: Department of Zoology, Berhampur University, Berhampur 760 007, Orissa, India.
authors.forename: R C
authors.initials: RC
authors.lastname: Choudhury
authors.forename: S K
authors.initials: SK
authors.lastname: Ghosh
authors.forename: A K
authors.initials: AK
authors.lastname: Palo