title: Pattern of P50 suppression deficit in patients with epilepsy and individuals with schizophrenia.
abstract: OBJECTIVE
  To identify P50 suppression in patients with epilepsy, to investigate the effect of seizure control on P50 suppression, and to compare epilepsy patients with individuals with schizophrenia and healthy volunteers.
  
  
  METHODS
  P50 evoked potential parameters and P50 suppression were studied crossectionally in patients with uncontrolled or controlled epilepsy, in individuals with schizophrenia and in healthy volunteers.
  
  
  RESULTS
  Individuals with schizophrenia had significantly smaller conditioning stimulus (S1) amplitude, and patients with epilepsy had larger test stimulus (S2) amplitude. Mean S2/S1 ratio was 0.71 ± 0.33 for patients with uncontrolled epilepsy; 0.68 ± 0.36 for patients with controlled epilepsy; 0.96 ± 0.47 for individuals with schizophrenia, and 0.42 ± 0.24 for healthy volunteers.
  
  
  CONCLUSIONS
  The sensory filter of patients with epilepsy is altered, and this alteration is not associated with seizure control. Also, it works differently from the sensory filter of individuals with schizophrenia.
authors.affiliation: Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre RS, Brazil. jeffersonbecker@hotmail.com
authors.forename: Jefferson
authors.initials: J
authors.lastname: Becker
authors.forename: Irenio Gomes da
authors.initials: IG
authors.lastname: Silva Filho
authors.forename: Hélio Fernandes da Silva
authors.initials: HF
authors.lastname: Filho
authors.forename: Alice
authors.initials: A
authors.lastname: Schuch
authors.forename: Fernanda Lia de Paula
authors.initials: FL
authors.lastname: Ramos
authors.forename: Eduardo Sörensen
authors.initials: ES
authors.lastname: Ghisolfi
authors.forename: Diogo Rizzato
authors.initials: DR
authors.lastname: Lara
authors.forename: Jaderson Costa da
authors.initials: JC
authors.lastname: Costa
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D012559:Schizophrenia / Q000503:physiopathology*; D055815:Young Adult