title: Prospective motion correction improves diagnostic utility of pediatric MRI scans.
abstract: A new technique for prospectively correcting head motion (called PROMO) during acquisition of high-resolution MRI scans has been developed to reduce motion artifacts. To evaluate the efficacy of PROMO, four T1-weighted image volumes (two with PROMO enabled, two uncorrected) were acquired for each of nine children. A radiologist, blind to whether PROMO was used, rated image quality and artifacts on all sagittal slices of every volume. These ratings were significantly better in scans collected with PROMO relative to those collected without PROMO (Mann-Whitney U test, P < 0.0001). The use of PROMO, especially in motion-prone patients, should improve the accuracy of measurements made for clinical care and research, and potentially reduce the need for sedation in children.
authors.affiliation: jkuperman@ucsd.edu
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Kuperman
authors.forename: Timothy T
authors.initials: TT
authors.lastname: Brown
authors.forename: Mazyar E
authors.initials: ME
authors.lastname: Ahmadi
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Erhart
authors.forename: Nathan S
authors.initials: NS
authors.lastname: White
authors.forename: J Cooper
authors.initials: JC
authors.lastname: Roddey
authors.forename: Ajit
authors.initials: A
authors.lastname: Shankaranarayanan
authors.forename: Eric T
authors.initials: ET
authors.lastname: Han
authors.forename: Dan
authors.initials: D
authors.lastname: Rettmann
authors.forename: Anders M
authors.initials: AM
authors.lastname: Dale
mesh_terms: D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology*; D002648:Child; D005260:Female; D019416:Head Movements; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009038:Motion; D015588:Observer Variation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity