title: A comparison of multislice computerized tomography, cone-beam computerized tomography, and single photon emission computerized tomography for the assessment of bone invasion by oral malignancies.
abstract: OBJECTIVE
  The aim of this study was to compare the performance of cone-beam computerized tomography (CBCT) with multislice CT (MSCT) and single photon emission CT (SPECT) in the detection of bone invasion from oral malignancies.
  
  
  METHODS
  In this prospective investigation, 77 patients with histologically proven malignancy of the oral cavity received MSCT, CBCT, and SPECT imaging of the head presurgically. Radiologic evaluations were compared with histopathologic examinations of the resected tumor specimens. Receiver operating characteristic (ROC) analysis as well as the sensitivity, specificity, and positive and negative predictive values were calculated.
  
  
  RESULTS
  The sensitivity, specificity, positive predictive value, and negative predictive value for MSCT were 0.8, 1.0, 1.0, and 0.75, respectively; for CBCT 0.92, 0.965, 0.98, and 0.875; and for SPECT 0.91, 0.4, 0.7, and 0.75. ROC analysis showed area under the curve values of 0.894 (95% confidence interval [CI] 0.806-0.982) for MSCT; 0.931 (95% CI 0.835-1.000) for CBCT, and 0.716 (95% CI 0.566-0.866) for SPECT.
  
  
  CONCLUSIONS
  CBCT is accurate in predicting malignancies' bone involvement and can compete with MSCT and SPECT in detecting bone invasion in patients with oral malignancies.
authors.affiliation: Faculty Member, Department of Craniomaxillofacial and Plastic Surgery, University of Cologne, Cologne, Germany. timo.dreiseidler@uk-koeln.de
authors.forename: Timo
authors.initials: T
authors.lastname: Dreiseidler
authors.forename: Nuri
authors.initials: N
authors.lastname: Alarabi
authors.forename: Lutz
authors.initials: L
authors.lastname: Ritter
authors.forename: Daniel
authors.initials: D
authors.lastname: Rothamel
authors.forename: Martin
authors.initials: M
authors.lastname: Scheer
authors.forename: Joachim E
authors.initials: JE
authors.lastname: Zöller
authors.forename: Robert A
authors.initials: RA
authors.lastname: Mischkowski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology; D054893:Cone-Beam Computed Tomography; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008441:Maxillary Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D061330:Multidetector Computed Tomography; D009361:Neoplasm Invasiveness / Q000000981:diagnostic imaging*; D009367:Neoplasm Staging / Q000295:instrumentation; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000473:pathology; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000295:instrumentation* / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon