title: Immunomodulatory activity of Lactobacillus strains isolated from fermented vegetables and infant stool.
abstract: Four Lactobacillus strains - Lactobacillus plantarum CJLP133, L. plantarum CJLP243, L. plantarum CJNR26, and Lactobacillus gasseri CJMF3 - were isolated from Korean fermented food or healthy infant feces, and their capacity to modulate cellular and humoral immune responses was studied. Feeding of the tested lactobacilli for 8 weeks did not alter the weight of and cell numbers in the spleen of mice. However, CJLP133 and CJLP243 strains increased the T lymphocyte population in the spleen of mice, while CJNR26 and CJMF3 increased the B lymphocyte population. In splenocytes treated with concanavalin A, ingestion of CJLP133 and CJLP243 promoted T lymphocyte proliferation and secretion of T cell cytokines, whereas feeding of the CJNR26 and CJMF3 strains enhanced B lymphocyte proliferation in splenocytes treated with lipopolysaccharide and plaque formation. These results suggest that CJLP133 and CJLP243 have immunostimulating activity through the enhancement of T cell activation, while CJNR26 and CJMF3 exhibit immunopotentiation through the increment of B cell activation.
authors.affiliation: Immune Modulation Laboratory, College of Pharmacy, Chung-Ang University, 221 Heukseok-dong, Dongjak-gu, Seoul 156-756, Korea.
authors.forename: Tae Joon
authors.initials: TJ
authors.lastname: Won
authors.forename: Bongjoon
authors.initials: B
authors.lastname: Kim
authors.forename: Eun Seul
authors.initials: ES
authors.lastname: Oh
authors.forename: Joon Seok
authors.initials: JS
authors.lastname: Bang
authors.forename: Yoon Jeong
authors.initials: YJ
authors.lastname: Lee
authors.forename: Jong-Sun
authors.initials: JS
authors.lastname: Yoo
authors.forename: Hyunmin
authors.initials: H
authors.lastname: Yu
authors.forename: Joowon
authors.initials: J
authors.lastname: Yoon
authors.forename: Kyeong Eun
authors.initials: KE
authors.lastname: Hyung
authors.forename: So-Young
authors.initials: SY
authors.lastname: Park
authors.forename: Kwang Woo
authors.initials: KW
authors.lastname: Hwang
mesh_terms: D000818:Animals; D002452:Cell Count; D016207:Cytokines / Q000032:analysis; D005243:Feces / Q000382:microbiology*; D005260:Female; D005285:Fermentation; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology / Q000494:pharmacology*; D007223:Infant; D007778:Lactobacillus / Q000276:immunology* / Q000302:isolation & purification*; D048191:Lactiplantibacillus plantarum / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics / Q000494:pharmacology*; D011897:Random Allocation; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology; D014675:Vegetables / Q000382:microbiology*
chemical_list: D016207:Cytokines; D007155:Immunologic Factors