title: Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses.
abstract: Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized as scavengers and agents of the innate and the acquired immune systems. Because of their plasticity, macrophages are endowed with many other essential roles during development and tissue homeostasis. We present evidence that CSF-1 plays an important trophic role in postnatal organ growth and kidney repair. Notably, the injection of CSF-1 postnatally enhanced kidney weight and volume and was associated with increased numbers of tissue macrophages. Moreover, CSF-1 promotes postnatal renal repair in mice after ischemia-reperfusion injury by recruiting and influencing macrophages toward a reparative state. CSF-1 treatment rapidly accelerated renal repair with tubular epithelial cell replacement, attenuation of interstitial fibrosis, and functional recovery. Analysis of macrophages from CSF-1-treated kidneys showed increased expression of insulin-like growth factor-1 and anti-inflammatory genes that are known CSF-1 targets. Taken together, these data suggest that CSF-1 is important in kidney growth and the promotion of endogenous repair and resolution of inflammatory injury.
authors.affiliation: Monash Immunology and Stem Cell Laboratories (MISCL), Monash University, Melbourne, Australia.
authors.forename: Maliha A
authors.initials: MA
authors.lastname: Alikhan
authors.forename: Christina V
authors.initials: CV
authors.lastname: Jones
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Williams
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Beckhouse
authors.forename: Anne L
authors.initials: AL
authors.lastname: Fletcher
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Kett
authors.forename: Samy
authors.initials: S
authors.lastname: Sakkal
authors.forename: Chrishan S
authors.initials: CS
authors.lastname: Samuel
authors.forename: Robert G
authors.initials: RG
authors.lastname: Ramsay
authors.forename: James A
authors.initials: JA
authors.lastname: Deane
authors.forename: Christine A
authors.initials: CA
authors.lastname: Wells
authors.forename: Melissa H
authors.initials: MH
authors.lastname: Little
authors.forename: David A
authors.initials: DA
authors.lastname: Hume
authors.forename: Sharon D
authors.initials: SD
authors.lastname: Ricardo
mesh_terms: D058186:Acute Kidney Injury / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism; D020869:Gene Expression Profiling; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009929:Organ Size / Q000187:drug effects; D010641:Phenotype; D020127:Recovery of Function; D015427:Reperfusion Injury / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D016173:Macrophage Colony-Stimulating Factor; D003094:Collagen