title: Chemotaxis in cancer.
abstract: Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.
authors.affiliation: Department of Anatomy and Structural Biology, Program in Tumor Microenvironment and Metastasis, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.
authors.forename: Evanthia T
authors.initials: ET
authors.lastname: Roussos
authors.forename: John S
authors.initials: JS
authors.lastname: Condeelis
authors.forename: Antonia
authors.initials: A
authors.lastname: Patsialou
mesh_terms: D000818:Animals; D002465:Cell Movement; D002633:Chemotaxis; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D011379:Prognosis; D014407:Tumor Cells, Cultured