title: CT-guided high-dose-rate brachytherapy of metachronous ovarian cancer metastasis to the liver: initial experience.
abstract: OBJECTIVE
  Hepatic resection for hepatic ovarian cancer metastases remains controversial. The purpose of this study was to evaluate the clinical outcome of CT-guided high dose rate brachytherapy (CT-HDRBT) for minimally invasive cytoreduction of isolated metachronous ovarian cancer metastases to the liver.
  
  
  METHODS
  Seven patients with 12 isolated ovarian cancer metastases to the liver were treated with CT-HDRBT. To evaluate tumor response a gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced liver MRI was performed before, six weeks after and every third month after treatment.
  
  
  RESULTS
  The mean MRI-follow-up period was 15.4 months. Tumors ranged from 13 to 120 mm in diameter. Complete ablation was achieved for all lesions. No complications occurred. No local progression was observed in any of the included patients. Overall survival was 100% after 12 months. Two patients died after 14 and 25 months, respectively.
  
  
  CONCLUSIONS
  CT-HDRBT is a safe and valid technique for performing minimally invasive cytoreduction of metachronous isolated liver metastases from ovarian cancer.
authors.affiliation: Charité, Campus Mitte, Charitelatz 1, 10117 Berlin, Germany. federico.collettini@charite.de
authors.forename: Federico
authors.initials: F
authors.lastname: Collettini
authors.forename: Alexander
authors.initials: A
authors.lastname: Poellinger
authors.forename: Dirk
authors.initials: D
authors.lastname: Schnapauff
authors.forename: Timm
authors.initials: T
authors.lastname: Denecke
authors.forename: Peter
authors.initials: P
authors.lastname: Wust
authors.forename: Ioana Elena
authors.initials: IE
authors.lastname: Braicu
authors.forename: Jalid
authors.initials: J
authors.lastname: Sehouli
authors.forename: Bernd
authors.initials: B
authors.lastname: Hamm
authors.forename: Bernhard
authors.initials: B
authors.lastname: Gebauer
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA