title: Dyslipidemia in subclinical hypothyroidism in an Indian population.
abstract: OBJECTIVE
  In view of inconsistent reports on the prevalence of dyslipidemia in subclinical hypothyroidism (SCH), we studied lipid abnormalities in Indian subjects with SCH.
  
  
  METHODS
  A cross sectional study of 5343 subjects divided in two groups, Group-1 (age≤18 years) and Group-2 (age>18 years) was undertaken. They were further subdivided on the basis of their thyroid functional status: Normal (Control); SCH with TSH≤10.0mIU/L (SCH-1); and SCH with TSH>10mIU/L (SCH-2).
  
  
  RESULTS
  Prevalence of SCH was 14.7%. The only lipid abnormality in children and adolescents was low HDL in subjects with TSH>10mIU/L compared with controls. Serum total cholesterol (TC), and LDL cholesterol (LDL) were significantly higher in adults with TSH>10mIU/L compared to controls. There were no significant changes in lipid parameters in subjects with SCH having TSH≤10.0mIU/L, compared to controls. Serum TSH was positively and FT3 and FT4 were negatively correlated with TC and LDL.
  
  
  CONCLUSIONS
  Atherogenic lipid abnormalities were observed in adult subjects with SCH-2 (TSH>10.0mIU/L), and not in subjects with SCH-1 who had TSH≤10.0mIU/L in Indian population.
authors.affiliation: Department of Endocrinology and Thyroid Research Centre, Institute of Nuclear Medicine & Allied Sciences, Delhi, India. marwaha_ramank@hotmail.com
authors.forename: Raman K
authors.initials: RK
authors.lastname: Marwaha
authors.forename: Nikhil
authors.initials: N
authors.lastname: Tandon
authors.forename: M K
authors.initials: MK
authors.lastname: Garg
authors.forename: Ratnesh
authors.initials: R
authors.lastname: Kanwar
authors.forename: A
authors.initials: A
authors.lastname: Sastry
authors.forename: A
authors.initials: A
authors.lastname: Narang
authors.forename: S
authors.initials: S
authors.lastname: Arora
authors.forename: Kuntal
authors.initials: K
authors.lastname: Bhadra
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000453:epidemiology* / Q000378:metabolism*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000378:metabolism; D007194:India; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D013972:Thyrotropin; D002784:Cholesterol