title: The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities.
abstract: The synthesis of selenium analogues of de-O-sulfonated ponkoranol, a naturally occurring sulfonium-ion glucosidase inhibitor isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against two recombinant intestinal enzymes maltase glucoamylase (MGAM) and sucrase isomaltase (SI) are described.
authors.affiliation: Department of Chemistry, Simon Fraser University, Burnaby, British Colombia, Canada V5A 1S6.
authors.forename: Razieh
authors.initials: R
authors.lastname: Eskandari
authors.forename: Kyra
authors.initials: K
authors.lastname: Jones
authors.forename: David R
authors.initials: DR
authors.lastname: Rose
authors.forename: B Mario
authors.initials: BM
authors.lastname: Pinto
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007422:Intestines / Q000201:enzymology*; D008958:Models, Molecular; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D049918:Salacia / Q000737:chemistry*; D012643:Selenium / Q000737:chemistry* / Q000494:pharmacology; D013455:Sulfur / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry* / Q000494:pharmacology; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D011994:Recombinant Proteins; D013876:Thiophenes; C550268:ponkoranol; D013455:Sulfur; D000520:alpha-Glucosidases; D012643:Selenium