title: Kinetic profiling of prolinate-catalyzed α-amination of aldehydes.
abstract: Deconvolution of the role of off-cycle species from the desired catalytic cycle leads to an optimized protocol for the prolinate-catalyzed amination of aldehydes. The scope of complex reaction networks will be greatly broadened by understanding ancillary rate processes that influence the productive catalytic pathway.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: Jason E
authors.initials: JE
authors.lastname: Hein
authors.forename: Alan
authors.initials: A
authors.lastname: Armstrong
authors.forename: Donna G
authors.initials: DG
authors.lastname: Blackmond
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D007700:Kinetics; D015394:Molecular Structure; D011392:Proline
chemical_list: D000447:Aldehydes; D011392:Proline