title: Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones.
abstract: A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.
authors.affiliation: Department of Medical Chemistry, First Faculty of Medicine, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Bielenica
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kossakowski
authors.forename: Marta
authors.initials: M
authors.lastname: Struga
authors.forename: Izabela
authors.initials: I
authors.lastname: Dybała
authors.forename: Roberta
authors.initials: R
authors.lastname: Loddo
authors.forename: Cristina
authors.initials: C
authors.lastname: Ibba
authors.forename: Paolo
authors.initials: P
authors.lastname: La Colla