title: Primary central nervous system lymphoma: a study of clinicopathological features and trend in western India.
abstract: BACKGROUND
  Primary central nervous system lymphoma (PCNSL) is rare and accounts for 1-2% of all primary intracranial tumors (ICT). There are conflicting reports regarding the increased incidence of PCNSL over the last two decades in both immunocompromised and immunocompetent patients.
  
  
  OBJECTIVE
  This study was designed to study the clinicopathological characteristics of PCNSL and to access the trend of PCNSL at our institute.
  
  
  METHODS
  All the histopathologically proven cases of PCNSL were reviewed from January 1997 to December 2009 (13 years). Immunophenotyping was performed on available paraffin-embedded tissue blocks. Immune status was evaluated and human immunodeficiency virus (HIV) serology was performed in all cases. Cerebrospinal fluid (CSF) findings were recorded whenever available. Possibility of secondary involvement by a systemic lymphoma was excluded in every case. Statistical analysis was done using χ2 -test.
  
  
  RESULTS
  During the study period (13 years), a total of 4715 cases of ICT were diagnosed, out of which 66 cases were PCNSL, which accounted for 1.4%. The age ranged from 10 to 75 years with a median age of 46 years. All the patients were immunocompetent. Frontal lobe was the most common site of involvement. Diffuse large B-cell lymphoma was the histological pattern in all the cases. CSF involvement was seen in only one case.
  
  
  CONCLUSIONS
  In this study, no significant increase in the incidence of PCNSL was found at our institute. Association of PCNSL cases with HIV or acquired immunodeficiency syndrome was not found in our study.
authors.affiliation: Department of Pathology, The Gujarat Cancer and Research Institute (M. P. Shah Cancer Hospital), NCH Campus, Asarwa, Ahmedabad 380 016, Gujarat, India. drsunilpasricha@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Pasricha
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: J
authors.initials: J
authors.lastname: Gawande
authors.forename: P
authors.initials: P
authors.lastname: Trivedi
authors.forename: D
authors.initials: D
authors.lastname: Patel
mesh_terms: D000328:Adult; D000368:Aged; D016543:Central Nervous System Neoplasms / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D015994:Incidence; D007194:India / Q000453:epidemiology; D008223:Lymphoma / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis