title: Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population.
abstract: BACKGROUND
  Genome-wide studies have shown that polymorphisms on chromosome 4q25, 16q22 and 1q21 correlate with atrial fibrillation (AF). However, the distribution of these polymorphisms differs significantly among populations.
  
  
  OBJECTIVE
  To test the polymorphisms on chromosome 4q25, 16q22 and 1q21 in a group of patients (pts) that underwent catheter ablation of AF.
  
  
  METHODS
  Four hundred and ten patients with AF that underwent pulmonary vein isolation were included in the study. Control group (n = 550) was taken from healthy population, matched for age, sex and presence of hypertension. All participants were genotyped for the presence of the rs2200733, rs10033464, rs17570669, rs3853445, rs6838973 (4q25), rs7193343 (16q22) and rs13376333 (1q21) polymorphisms.
  
  
  RESULTS
  All the polymorphisms tested (except rs17570669) correlated significantly with AF in univariate analysis (p values between 0.039 for rs7193343 and 2.7e-27 for rs2200733), with the odds ratio (OR) 0.572 and 0.617 for rs3853445 and rs6838973, respectively (protective role) and OR 1.268 to 3.52 for the other polymorphisms. All 4q25 SNPs tested but rs3853445 were independently linked with AF in multivariate logistic regression analysis. In haplotype analysis six out of nine 4q25 haplotypes were significantly linked with AF. The T allele of rs2200733 favoured increased number of episodes of AF per month (p = 0.045) and larger pulmonary vein diameter (recessive model, p = 0.032).
  
  
  CONCLUSIONS
  Patients qualified for catheter ablation of AF have a significantly higher frequency of 4q25, 16q22 and 1q21 variants than the control group. The T allele of rs2200733 favours larger pulmonary veins and increased number of episodes of AF.
authors.affiliation: First Department of Cardiology, Medical University of Warsaw, Warsaw, Poland. kiliszek@mp.pl
authors.forename: Marek
authors.initials: M
authors.lastname: Kiliszek
authors.forename: Maria
authors.initials: M
authors.lastname: Franaszczyk
authors.forename: Edward
authors.initials: E
authors.lastname: Kozluk
authors.forename: Piotr
authors.initials: P
authors.lastname: Lodzinski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Piatkowska
authors.forename: Grażyna
authors.initials: G
authors.lastname: Broda
authors.forename: Rafal
authors.initials: R
authors.lastname: Ploski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Opolski
mesh_terms: D001281:Atrial Fibrillation / Q000235:genetics*; D016022:Case-Control Studies; D002877:Chromosomes, Human / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009929:Organ Size; D011044:Poland; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011667:Pulmonary Veins / Q000473:pathology; D012307:Risk Factors