title: Management of anterior mediastinal masses in children.
abstract: BACKGROUND
  Children with anterior mediastinal masses are at risk for life-threatening airway compromise during anesthesia, and can present a diagnostic and management challenge for pediatric surgeons.
  
  
  METHODS
  We performed a retrospective chart review of all children presenting with an anterior mediastinal mass from 1994-2009. Parameters studied included demographics, historical and physical findings at diagnosis, radiographic evidence of airway compression, diagnostic studies, diagnosis, and complications.
  
  
  RESULTS
  There were 26 patients with anterior mediastinal masses over a 15-year period. The mean age was 11.3 years, and there were no gender differences. The diagnoses were lymphoma (62%, 16/26), leukemia (15%, 4/26), and other (23%, 6/26). Diagnosis was made by CBC/peripheral smear in 2/4 patients with leukemia, by bone marrow biopsy in 2/4 patients with leukemia, by thoracentesis in 3/16 patients with lymphoma, by lymph node biopsies in 6/16 patients with lymphoma, and by biopsy of a mediastinal mass in 7/16 patients with lymphoma and in 6/6 patients with other diagnoses. Radiographic evidence of airway compression was seen in 62% (16/26) of children. Only 12% (3/26) had a tracheal cross-sectional area (TCA) <50%. Correlation of symptoms with anatomical airway obstruction or complications was poor. Pulmonary function studies were obtained in 38%, 10/26 children. Only 2 children had a PEFR (peak expiratory flow rate) <50% predicted. This data also correlated poorly with anatomical airway obstruction or complications. 3 patients had anesthesia-related complications: one desaturation during induction prior to median sternotomy, one with significant desaturation and bradycardia during biopsy under local anesthesia with minimal sedation, and one with prolonged (5 days) mechanical ventilation after general anesthesia. 2 of these patients had a TCA <50%, and 2 had SVC obstructions. There were no anesthesia-related deaths, and the overall survival was 85% (22/26).
  
  
  CONCLUSIONS
  Anterior mediastinal masses in children should be approached in a step-wise fashion with multi-disciplinary involvement, starting with the least invasive techniques and progressing cautiously. The surgeon should have a well-defined and preoperatively established contingency plan if these children require general anesthesia for diagnosis.
authors.affiliation: Department of Surgery, Children's Mercy Hospital, Kansas City 64108, United States.
authors.forename: C L
authors.initials: CL
authors.lastname: Garey
authors.forename: C A
authors.initials: CA
authors.lastname: Laituri
authors.forename: P A
authors.initials: PA
authors.lastname: Valusek
authors.forename: S D
authors.initials: SD
authors.lastname: St Peter
authors.forename: C L
authors.initials: CL
authors.lastname: Snyder
mesh_terms: D000402:Airway Obstruction / Q000209:etiology / Q000628:therapy*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D008482:Mediastinum; D012189:Retrospective Studies