title: Polymorphisms in nucleotide excision repair genes and endometrial cancer risk.
abstract: BACKGROUND
  Exposure to estrogens increases the risk of endometrial cancer. Certain estrogen metabolites can form bulky DNA adducts, which are removed via nucleotide excision repair (NER), and the ability to carry out this repair might be related to endometrial cancer risk.
  
  
  METHODS
  We examined 64 tag and functional single-nucleotide polymorphisms (SNPs) in the NER genes ERCC1, ERCC2 (XPD), ERCC3 (XPB), ERCC4 (XPF), ERCC5 (XPG), LIG1, XPA, and XPC in a population-based case-control study in Washington state, with 783 endometrial cancer cases and 795 controls.
  
  
  RESULTS
  The presence of ERCC5 rs4150386 C, LIG1 rs3730865 C, XPA rs2808667 T, or XPC rs3731127 T alleles was associated with risk of endometrial cancer, with respective age-, county-, and reference year-adjusted per-allele ORs and 95% CIs of 0.68 (0.53-0.87, P = 0.002), 1.46 (1.02-2.10, P = 0.04), 0.71 (0.52-0.97, P = 0.03), and 1.57 (1.13-2.17, P = 0.007), respectively.
  
  
  CONCLUSIONS
  Certain ERCC5, LIG1, XPA, and XPC genotypes might influence endometrial cancer risk.
  
  
  CONCLUSIONS
  Because of multiple redundancies in DNA repair pathways (and therefore a low prior probability) and the large number of associations examined, false-positive findings are likely. Further characterization of the relation between variation in NER genes and endometrial cancer risk is warranted.
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Doherty
authors.forename: Noel S
authors.initials: NS
authors.lastname: Weiss
authors.forename: Sherianne
authors.initials: S
authors.lastname: Fish
authors.forename: Wenhong
authors.initials: W
authors.lastname: Fan
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Loomis
authors.forename: Lori C
authors.initials: LC
authors.lastname: Sakoda
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Rossing
authors.forename: Lue Ping
authors.initials: LP
authors.lastname: Zhao
authors.forename: Chu
authors.initials: C
authors.lastname: Chen
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D004265:DNA Helicases / Q000235:genetics; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000235:genetics; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics; D051760:Xeroderma Pigmentosum Group A Protein / Q000235:genetics; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics; D000099250:DNA Excision Repair Protein ERCC-5
chemical_list: D004265:DNA Helicases; D000072481:DNA Ligase ATP; D011088:DNA Ligases; D004268:DNA-Binding Proteins; D004720:Endonucleases; D009687:Nuclear Proteins; D014157:Transcription Factors; D051760:Xeroderma Pigmentosum Group A Protein; D051759:Xeroderma Pigmentosum Group D Protein; D000099250:DNA Excision Repair Protein ERCC-5; C000607892:LIG1 protein, human; C497314:XPA protein, human; C095888:xeroderma pigmentosum group F protein; C072022:XPBC-ERCC-3 protein; C086984:XPC protein, human; C071447:ERCC1 protein, human; C497292:ERCC2 protein, human