title: Interleukin-10 polymorphisms and tuberculosis susceptibility: a meta-analysis.
abstract: BACKGROUND
  A large number of studies have shown that polymorphisms in the interleukin 10 (IL-10) gene are implicated in susceptibility to tuberculosis (TB). However, the results are inconsistent and inconclusive.
  
  
  OBJECTIVE
  A meta-analysis was performed to analyse the association between polymorphisms in the IL-10 gene and TB susceptibility.
  
  
  RESULTS
  A total of 18 studies that referred to three polymorphisms (-1082G/A, -819C/T and -592A/C) were identified. No association was found between these three polymorphisms and TB risk in combined analyses: -1082G/A (AA+AG vs. GG): OR 0.87, 95%CI 0.66-1.14, P = 0.30; -819C/T (TT+TC vs. CC): OR 1.02, 95%CI 0.92-1.14, <e1>P</e> = 0.66; -592A/C (CC+CA vs. AA): OR 0.99, 95%CI 0.88-1.11, P = 0.82. However, in the subgroup analysis by ethnicity, European subjects with the -1082(AA+GG) genotypes have a decreased risk of TB: OR 0.55, 95%CI 0.35-0.88, P = 0.01.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the -1082G/A polymorphism of the IL-10 gene could be a risk factor for TB in Europeans. Further studies with larger populations are required to assess the association between IL-10 polymorphisms and TB susceptibility.
authors.affiliation: Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: X-B
authors.initials: XB
authors.lastname: Nie
authors.forename: W-H
authors.initials: WH
authors.lastname: Wu
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: X-M
authors.initials: XM
authors.lastname: He
authors.forename: J-X
authors.initials: JX
authors.lastname: Lu
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014376:Tuberculosis / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D016753:Interleukin-10