title: Polymorphisms of human vascular endothelial growth factor gene are associated with acute cerebral infarction in the Chinese population.
abstract: OBJECTIVE
  Vascular endothelial growth factor (VEGF) plays a key role in the development of cerebral infarction as a major mediator of angiogenesis. The aim of this study was to investigate whether the VEGF gene polymorphisms were associated with the risks of acute cerebral infarction.
  
  
  METHODS
  We examined the distribution of three single nucleotide polymorphisms (SNPs), -1154G/A, 936C/T and -2578C/A, in the promoter and coding region of the VEGF gene in DNA samples from 147 Chinese patients with acute cerebral infarction and 131 control subjects.
  
  
  RESULTS
  There was no significant difference in allele and genotype distributions of -1154G/A, 936C/T and -2578C/A with the risk of acute cerebral infarction when compared with controls. However, haplotype analysis from the above-mentioned three polymorphisms showed that haplotype ACC was significantly lower in patients with acute cerebral infarction (0.020) than in controls (0.054) (p = 0.034).
  
  
  CONCLUSIONS
  These data suggested that the -1154/, 936/ and -2578/ ACC haplotype was associated with the risk of acute cerebral infarction with an OR of 0.361, and it may reduce the risk of acute cerebral infarction through the regulation of VEGF expression.
authors.affiliation: Department of Neurology and Institute of Neurology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Fu
authors.forename: Peihua
authors.initials: P
authors.lastname: Ni
authors.forename: Jianfang
authors.initials: J
authors.lastname: Ma
authors.forename: Yayun
authors.initials: Y
authors.lastname: Ying
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Jianrong
authors.initials: J
authors.lastname: Liu
authors.forename: Shengdi
authors.initials: S
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000175:diagnosis / Q000235:genetics*; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A