title: Synthesis and biological properties of macrolactam analogs of the natural product macrolide (-)-A26771B.
abstract: Promising synthetic derivatives of macrolactone natural product (-)-A26771B have been designed and synthesized both from semisynthesis and total synthesis. Further optimization led to the first synthesis of macrolactam analogs of (-)-A26771B with improved antibacterial activity and metabolic stability.
authors.affiliation: Edelris, 115 Avenue Lacassagne, 69003 Lyon, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Canova
authors.forename: Renaud
authors.initials: R
authors.lastname: Lépine
authors.forename: Amber
authors.initials: A
authors.lastname: Thys
authors.forename: Anne
authors.initials: A
authors.lastname: Baron
authors.forename: Didier
authors.initials: D
authors.lastname: Roche
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001685:Biological Factors / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D007783:Lactones / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001685:Biological Factors; D007783:Lactones; C014929:A26771B