title: Rethinking treatment of acne in the severe patient.
abstract: Managing acne continues to be a challenge. The data presented here provide a rationale for rethinking our approach to the use of oral antibiotics in moderate-to-severe acne and suggest strategies that favor combination regimens that limit the use of oral antibiotics.
authors.affiliation: Department of Dermatology Research Laboratory, Milton S. Hershey Medical Center, Pennsylvania State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Thiboutot
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D000279:Administration, Cutaneous; D000284:Administration, Oral; D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial; D006801:Humans; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D003879:Dermatologic Agents; D004338:Drug Combinations; D012176:Retinoids; D001585:Benzoyl Peroxide