title: Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effects.
authors.affiliation: Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois 60612, USA.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Chen
authors.forename: Irina N
authors.initials: IN
authors.lastname: Gaisina
authors.forename: Hendra
authors.initials: H
authors.lastname: Gunosewoyo
authors.forename: Sam A
authors.initials: SA
authors.lastname: Malekiani
authors.forename: Taleen
authors.initials: T
authors.lastname: Hanania
authors.forename: Alan P
authors.initials: AP
authors.lastname: Kozikowski
mesh_terms: D000818:Animals; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D047069:Pyrazolones / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D018696:Neuroprotective Agents; D047069:Pyrazolones; C038362:pyrazolone; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; C000605508:Gsk3b protein, rat; D038362:Glycogen Synthase Kinase 3