title: Monitoring neoadjuvant chemotherapy in breast cancer patients: improved MR assessment at 3 T?
abstract: OBJECTIVE
  To investigate possible improvements in predicting the response to neoadjuvant chemotherapy (NAC) at 3 T for locally advanced breast cancer (LABC).
  
  
  METHODS
  Dynamic contrast-enhanced magnetic resonance (DCE-MR) images acquired before and during NAC were retrospectively analyzed in 85 patients. Tumor volume and diameter, three volumes based on the shape of the enhancement curve, relative signal intensity, area under the curve, and the signal-to-noise ratio were extracted. Differences between responders and nonresponders at the same and between MR timepoints during treatment were evaluated.
  
  
  RESULTS
  A higher signal-to-noise ratio was observed on 3 T images compared to 1.5 T, and 3 T revealed more significant findings related to response compared to 1.5 T. The DCE-MRI-derived volume parameters were the earliest predictors of response at both 1.5 and 3 T.
  
  
  CONCLUSIONS
  Our results show that 3 T provides an improved assessment of the response to NAC in LABC patients, where the MR determined tumor volume reduction before the second cycle of NAC was the strongest and earliest predictor of a response.
authors.affiliation: Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. mariann.g.heldahl@ntnu.no
authors.forename: Mariann G
authors.initials: MG
authors.lastname: Heldahl
authors.forename: Steinar
authors.initials: S
authors.lastname: Lundgren
authors.forename: Line R
authors.initials: LR
authors.lastname: Jensen
authors.forename: Ingrid S
authors.initials: IS
authors.lastname: Gribbestad
authors.forename: Tone F
authors.initials: TF
authors.lastname: Bathen
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents