title: Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels.
abstract: The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP-sensitive potassium channels (KATP) and cGMP, respectively.
authors.affiliation: Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Gohar
authors.initials: G
authors.lastname: Fakhfouri
authors.forename: Reza
authors.initials: R
authors.lastname: Rahimian
authors.forename: Saeed
authors.initials: S
authors.lastname: Hashemi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Rasouli
authors.forename: Arash
authors.initials: A
authors.lastname: Bahremand
authors.forename: Shahram Ejtemaei
authors.initials: SE
authors.lastname: Mehr
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Khorramizadeh
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Dehpour
mesh_terms: D000818:Animals; D003092:Colitis / Q000188:drug therapy* / Q000503:physiopathology; D006152:Cyclic GMP / Q000378:metabolism*; D004195:Disease Models, Animal; D005905:Glyburide / Q000494:pharmacology; D054086:KATP Channels / Q000378:metabolism*; D008297:Male; D058986:Phosphodiesterase 5 Inhibitors / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000494:pharmacology*; D014302:Trinitrobenzenesulfonic Acid / Q000633:toxicity
chemical_list: D054086:KATP Channels; D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014302:Trinitrobenzenesulfonic Acid; D000068677:Sildenafil Citrate; D006152:Cyclic GMP; D005905:Glyburide