title: Total synthesis of landomycin A, a potent antitumor angucycline antibiotic.
abstract: The first total synthesis of landomycin A, the longest and most potent antitumor angucycline antibiotic, has been achieved in 63 steps and 0.34% overall yield starting from 2,5-dihydroxybenzoic acid, 3,5-dimethylphenol, triacetyl d-glucal, and d-xylose, with a convergent linear sequence of 21 steps.
authors.affiliation: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Yang
authors.forename: Boqiao
authors.initials: B
authors.lastname: Fu
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
mesh_terms: D000617:Aminoglycosides / Q000138:chemical synthesis*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D060326:Chemistry Techniques, Synthetic; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000737:chemistry; D014994:Xylose / Q000737:chemistry
chemical_list: D000617:Aminoglycosides; D000903:Antibiotics, Antineoplastic; C064648:landomycin A; C001289:d-glucal; D003847:Deoxyglucose; D014994:Xylose