title: Toxicokinetics of fumonisin B2 in ducks and turkeys.
abstract: Two extraction steps combined with HPLC with fluorescence detection were developed to determine the toxicokinetics of fumonisin B(2) (FB(2)) in ducks and turkeys. The limit of quantification of the method was 25 ng of FB(2)/mL. The mean extraction was 63%. After intravenous administration (single dose: 1 mg of FB(2)/kg of BW), plasma concentration time curves were best described by a 2-compartment open model. In ducks, elimination half-life, mean residence time, and clearance of FB(2) were 32 min, 12.9 min, and 9.3 mL/min per kilogram, respectively. In turkeys, these toxicokinetics parameters were 12.4 min, 5 min, and 8.7 mL/min per kilogram, respectively. Only a small amount of FB(2) was detected in plasma after oral dosing of 10 mg of FB(2)/kg of BW.
authors.affiliation: UR Mycotoxicologie, Université de Toulouse, Toulouse, France.
authors.forename: I
authors.initials: I
authors.lastname: Benlashehr
authors.forename: C
authors.initials: C
authors.lastname: Repussard
authors.forename: J-Y
authors.initials: JY
authors.lastname: Jouglar
authors.forename: D
authors.initials: D
authors.lastname: Tardieu
authors.forename: P
authors.initials: P
authors.lastname: Guerre
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000662:veterinary*; D004372:Ducks / Q000097:blood; D037341:Fumonisins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D006207:Half-Life; D007275:Injections, Intravenous; D015203:Reproducibility of Results; D014422:Turkeys / Q000097:blood
chemical_list: D037341:Fumonisins; C056934:fumonisin B2