title: Subthalamic local field beta oscillations during ongoing deep brain stimulation in Parkinson's disease in hyperacute and chronic phases.
abstract: In the past years, local field potential (LFP) signals recorded from the subthalamic nucleus (STN) in patients undergoing deep brain stimulation (DBS) for Parkinson's disease (PD) disclosed that DBS has a controversial effect on STN beta oscillations recorded 2-7 days after surgery for macroelectrode implantation. Nothing is known about these DBS-induced oscillatory changes 30 days after surgery. We recorded STN LFPs during ongoing DBS in 7 patients with PD, immediately (hyperacute phase) and 30 days (chronic phase) after surgery. STN LFP recordings showed stationary intranuclear STN beta LFP activity in hyperacute and chronic phases, confirming that beta peaks were also present in chronic recordings. Power spectra of nuclei with significant beta activity (54% of the sample) showed that it decreased significantly during DBS (p=0.021) under both recording conditions. The time course of beta activity showed more evident DBS-induced changes in the chronic than in the hyperacute phase (p=0.014). DBS-induced changes in STN beta LFPs in patients undergoing DBS in chronic phase provide useful information for developing a new neurosignal-controlled adaptive DBS system.
authors.affiliation: Centro Clinico per la Neurostimolazione, le Neurotecnologie ed i Disordini del Movimento, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italia.
authors.forename: Manuela
authors.initials: M
authors.lastname: Rosa
authors.forename: Gaia
authors.initials: G
authors.lastname: Giannicola
authors.forename: Domenico
authors.initials: D
authors.lastname: Servello
authors.forename: Sara
authors.initials: S
authors.lastname: Marceglia
authors.forename: Claudio
authors.initials: C
authors.lastname: Pacchetti
authors.forename: Mauro
authors.initials: M
authors.lastname: Porta
authors.forename: Marco
authors.initials: M
authors.lastname: Sassi
authors.forename: Emma
authors.initials: E
authors.lastname: Scelzo
authors.forename: Sergio
authors.initials: S
authors.lastname: Barbieri
authors.forename: Alberto
authors.initials: A
authors.lastname: Priori
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001611:Beta Rhythm / Q000502:physiology*; D002908:Chronic Disease; D046690:Deep Brain Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000145:classification / Q000503:physiopathology* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000502:physiology*; D013997:Time Factors