title: Myocardial strain assessment in cystic fibrosis.
abstract: BACKGROUND
  The aim of this work was to evaluate myocardial strain analysis as a tool for the early detection of left ventricular functional changes in patients with cystic fibrosis.
  
  
  METHODS
  A total of 42 consecutive patients (mean age, 24 ± 7.5 years; 52% men) diagnosed with cystic fibrosis and referred for echocardiographic cardiac function assessment were prospectively enrolled. A group of healthy age-matched and gender-matched volunteers (n = 42) formed the reference population for echocardiographic comparisons.
  
  
  RESULTS
  Left ventricular ejection fraction was conserved in both groups but was significantly lower in the cystic fibrosis group. Cardiac function assessment using Doppler tissue imaging parameters revealed that both systolic and diastolic measurements differed between the two groups: mitral peak systolic and diastolic velocities, as well as septal and lateral wall strain rates, were decreased in patients with cystic fibrosis, as was longitudinal strain of both the septal and lateral walls.
  
  
  CONCLUSIONS
  Using strain measurements, subclinical changes in left ventricular function were found in patients with cystic fibrosis. These parameters were correlated with the degree of pulmonary involvement severity. These findings have potentially significant clinical implications for the outcomes and follow-up of patients with cystic fibrosis, meriting further studies.
authors.affiliation: Department of Cardiology, CHU de Caen, Caen, France. labombarda-f@chu-caen.fr
authors.forename: Fabien
authors.initials: F
authors.lastname: Labombarda
authors.forename: Arnaud
authors.initials: A
authors.lastname: Pellissier
authors.forename: Madiha
authors.initials: M
authors.lastname: Ellafi
authors.forename: C
authors.initials: C
authors.lastname: Creveuil
authors.forename: Virginie
authors.initials: V
authors.lastname: Ribault
authors.forename: Murielle
authors.initials: M
authors.lastname: Laurans
authors.forename: Marcel
authors.initials: M
authors.lastname: Guillot
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bergot
authors.forename: Gilles
authors.initials: G
authors.lastname: Grollier
authors.forename: Paul
authors.initials: P
authors.lastname: Milliez
authors.forename: Gérard
authors.initials: G
authors.lastname: Zalcman
authors.forename: Eric
authors.initials: E
authors.lastname: Saloux
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018450:Disease Progression; D018618:Echocardiography, Doppler, Color / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D011379:Prognosis; D012720:Severity of Illness Index; D013318:Stroke Volume; D013599:Systole; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult