title: Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing.
abstract: The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection.
authors.affiliation: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA.
authors.forename: Srikanth
authors.initials: S
authors.lastname: Gottipati
authors.forename: Leonardo
authors.initials: L
authors.lastname: Arbiza
authors.forename: Adam
authors.initials: A
authors.lastname: Siepel
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Clark
authors.forename: Alon
authors.initials: A
authors.lastname: Keinan
mesh_terms: D002874:Chromosome Mapping; D041321:Chromosomes, Human, X / Q000235:genetics*; D003710:Demography; D005260:Female; D050172:Genes, X-Linked / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D015894:Genome, Human; D006801:Humans; D012641:Selection, Genetic