title: Circulating vaspin and its relationship with insulin sensitivity, adiponectin, and liver histology in subjects with non-alcoholic steatohepatitis.
abstract: OBJECTIVE
  Non-alcoholic steatohepatitis (NASH) is closely associated with components of metabolic syndrome. Vaspin is a novel adipocytokine that may link obesity, insulin resistance (IR), and type 2 diabetes mellitus. We aimed to investigate circulating vaspin levels in subjects with NASH and also to search for the association of vaspin with IR, adiponectin, and histological findings.
  
  
  METHODS
  A total of 50 male patients with NASH and 30 healthy male controls were enrolled. Vaspin and adiponectin were measured with ELISA method. Insulin sensitivity determined by homeostasis model assessment (HOMA-IR) index.
  
  
  RESULTS
  Plasma vaspin levels were higher and adiponectin levels were lower in NASH group compared with controls (p < 0.01 and p < 0.001, respectively). However, in multivariate analysis adjusted for glucose and lipid parameters, and HOMA-IR indexes, the difference in vaspin concentrations was disappeared. Nonetheless, the difference regarding the adiponectin levels remained significant between groups (p = 0.03). Vaspin was negatively correlated with low-density lipoprotein cholesterol (r = -0.32, p = 0.03) in subjects with NASH.
  
  
  CONCLUSIONS
  This study indicates that circulating vaspin levels are not altered in male subjects with NASH. These results suggest that in the absence of metabolic risk factors, vaspin per se may not be involved in the pathogenesis of NASH.
authors.affiliation: Department of Gastroenterology, Gulhane Medical School, Ankara, Turkey. zhgenc@yahoo.com
authors.forename: Halil
authors.initials: H
authors.lastname: Genc
authors.forename: Teoman
authors.initials: T
authors.lastname: Dogru
authors.forename: Serkan
authors.initials: S
authors.lastname: Tapan
authors.forename: Muammer
authors.initials: M
authors.lastname: Kara
authors.forename: Cemal Nuri
authors.initials: CN
authors.lastname: Ercin
authors.forename: Fatih
authors.initials: F
authors.lastname: Aslan
authors.forename: Murat
authors.initials: M
authors.lastname: Kantarcioglu
authors.forename: Yildirim
authors.initials: Y
authors.lastname: Karslioglu
authors.forename: Erdim
authors.initials: E
authors.lastname: Sertoglu
authors.forename: Mehmet Kemal
authors.initials: MK
authors.lastname: Erbil
authors.forename: Sait
authors.initials: S
authors.lastname: Bagci
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D005234:Fatty Liver / Q000097:blood* / Q000473:pathology*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease; D015843:Serpins / Q000097:blood*; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D008078:Cholesterol, LDL; C507339:SERPINA12 protein, human; D015843:Serpins