title: Effluent markers related to epithelial mesenchymal transition with adjusted values for effluent cancer antigen 125 in peritoneal dialysis patients.
abstract: Objectives. Epithelial mesenchymal transition (EMT) is important for peritoneal deterioration. We evaluated the association between peritoneal solute transport rate (PSTR) and effluent markers related to EMT with adjusted values for effluent cancer antigen 125 (CA125). Methods. One hundred five incident peritoneal dialysis (PD) patients on PD for 25 (12-68) months with biocompatible solutions were included in the study. Fast peritoneal equilibration test was used to evaluate PSTR. Effluent hepatocyte growth factor (HGF), bone morphogenic protein-7 (BMP-7), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), and CA125 at 4 h were measured. Results. Patients with dialysate/plasma creatinine ≧0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P < .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed. Conclusion. Increase in the effluent HGF levels as a compensatory mechanism is a marker of peritoneal deterioration, but controversy remains regarding adjusted value for CA125.
authors.affiliation: Department of Nephrology, Toho University School of Medicine, 6-11-1 Omori-Nishi, Ohta-ku, Tokyo 143-8541, Japan.
authors.forename: Sonoo
authors.initials: S
authors.lastname: Mizuiri
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Hemmi
authors.forename: Michitsune
authors.initials: M
authors.lastname: Arita
authors.forename: Reibin
authors.initials: R
authors.lastname: Tai
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Hattori
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Muto
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Ken
authors.initials: K
authors.lastname: Sakai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Aikawa