title: Uptake and translocation of metformin, ciprofloxacin and narasin in forage- and crop plants.
abstract: Transfer of bioactive organic compounds from soil to plants might represent animal and human health risks. Sewage sludge and manure are potential sources for bioactive compounds such as human- and veterinary drugs. In the present study, uptake of the anti-diabetic compound, metformin, the antibiotic agent ciprofloxacin and the anti-coccidial narasin in carrot (Daucuscarota ssp. sativus cvs. Napoli) and barley (Hordeumvulgare) were investigated. The pharmaceuticals were selected in order to cover various chemical properties, in addition to their presence in relevant environmental matrixes. The root concentration factors (RCF) found in the present study were higher than the corresponding leaf concentration factors (LCF) for the three test pharmaceuticals. The uptake of metformin was higher compared with ciprofloxacin and narasin for all plant compartments analyzed. Metformin was studied more explicitly with regard to uptake and translocation in meadow fescue (Festucapratense), three other carrot cultivars (D.carota ssp. sativus cvs. Amager, Rothild and Nutri Red), wheat cereal (Triticumaestivum) and turnip rape seed (Brassicacampestris). Uptake of metformin in meadow fescue was comparable with uptake in the four carrot cultivars (RCF 2-10, LCF approximately 1.5), uptake in wheat cereals were comparable with barley cereals (seed concentration factors, SCF, 0.02-0.04) while the accumulation in turnip rape seeds was as high as 1.5. All three pharmaceuticals produced negative effects on growth and development of carrots when grown in soil concentration of 6-10 mg kg(-1) dry weight.
authors.affiliation: Bioforsk, Norwegian Institute for Agricultural and Environmental Research, Postveien 213, N-4353 Klepp St., Norway. Trine.Eggen@bioforsk.no
authors.forename: Trine
authors.initials: T
authors.lastname: Eggen
authors.forename: Tone Normann
authors.initials: TN
authors.lastname: Asp
authors.forename: Kari
authors.initials: K
authors.lastname: Grave
authors.forename: Victor
authors.initials: V
authors.lastname: Hormazabal
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism*; D001692:Biological Transport; D002939:Ciprofloxacin / Q000378:metabolism*; D003049:Coccidiostats / Q000378:metabolism; D018552:Daucus carota / Q000378:metabolism*; D001467:Hordeum / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000378:metabolism*; D008687:Metformin / Q000378:metabolism*; D011714:Pyrans / Q000378:metabolism*; D012989:Soil Pollutants / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D003049:Coccidiostats; D007004:Hypoglycemic Agents; D011714:Pyrans; D012989:Soil Pollutants; D002939:Ciprofloxacin; D008687:Metformin; C013612:narasin