title: Urinary tract cancer in patients with hereditary non-polyposis colorectal cancer.
abstract: OBJECTIVE
  Hereditary non-polyposis colorectal cancer (HNPCC), or Lynch syndrome, is characterized as a hereditary colorectal cancer with an increased risk of cancer elsewhere in the body.
  
  
  METHODS
  In the Department of Urology at Odense University Hospital, screening for cancer in the urinary tract has been carried out on 20 patients with HNPCC since November 2001. Clinical records and pathology results were reviewed for all patients during the screening period.
  
  
  RESULTS
  During screening two patients without urological symptoms were found to have cancer in the ureter.
  
  
  CONCLUSIONS
  HNPCC patients with increased risk of urinary tract cancer should be referred for screening of the urinary tract. It is also important to discuss a rational strategy towards the screening of HNPCC patients for urinary tract cancer, and to initiate further investigation into this screening.
authors.affiliation: Department of Urology, Odense University Hospital, Odense, Denmark. peter_zachhau@hotmail.com
authors.forename: Peter
authors.initials: P
authors.lastname: Zachhau
authors.forename: Steen
authors.initials: S
authors.lastname: Walter
mesh_terms: D000328:Adult; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications*; D003718:Denmark; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D051718:MutS Homolog 2 Protein / Q000235:genetics; D009154:Mutation / Q000235:genetics; D012189:Retrospective Studies; D012307:Risk Factors; D014513:Ureter / Q000601:surgery; D014516:Ureteral Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000601:surgery
chemical_list: C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein