title: Dietary n-6 and n-3 polyunsaturated fatty acids and colorectal carcinogenesis: results from cultured colon cells, animal models and human studies.
abstract: During the past few decades, many studies have been conducted to evaluate the effects of n-6 and n-3 polyunsaturated fatty acids (PUFAs) on colorectal carcinogenesis. This report provides a brief overview of the recent studies that have been performed in cultured colon cells, animal models as well as of the population-based and short-term biomarker studies with humans. No differential effect between n-6 and n-3 PUFAs has been observed in vitro. Results from animal models indicate that n-6 PUFAs have a tumor enhancing effect, predominantly during the post-initiation phase. n-3 PUFAs may protect against colorectal carcinogenesis during both the initiation and post-initiation phase. Population-based human studies show little or no associations between n-6 or n-3 PUFA intake and colorectal cancer. Short-term biomarker studies in humans suggest though that fish oil (FO) supplementation with high amounts of n-3 PUFAs may protect against colorectal carcinogenesis and that n-6 PUFA supplementation may increase the risk.
authors.affiliation: WUR/TNO Centre for Food Toxicology, The Netherlands; Toxicology Group, Division of Toxicology, Wageningen University, Tuinlaan 5, PO Box 8000, 6700 EA Wageningen, The Netherlands.
authors.forename: Yvonne E M
authors.initials: YE
authors.lastname: Dommels
authors.forename: Gerrit M
authors.initials: GM
authors.lastname: Alink
authors.forename: Peter J
authors.initials: PJ
authors.lastname: van Bladeren
authors.forename: Ben
authors.initials: B
authors.lastname: van Ommen