title: Inflammation and wound healing in cats with chronic gingivitis/stomatitis after extraction of all premolars and molars were not affected by feeding of two diets with different omega-6/omega-3 polyunsaturated fatty acid ratios.
abstract: Feline chronic gingivitis/stomatitis (FCGS) is a painful inflammatory disease in cats. Extraction of teeth, including all premolars and molars, has been shown to be the therapy of choice in cats not responding sufficiently to home care (e.g. tooth brushing) and/or medical treatment (corticosteroids and/or antibiotics). In this study, we hypothesize that a cat food with an omega-6 polyunsaturated fatty acid (ω6 PUFA) to ω3 PUFA ratio of 10:1 reduces inflammation of the FCGS and accelerates soft tissue wound healing of the gingiva after dental extractions, compared to a cat food with a ω6:ω3 PUFA ratio of 40:1. The cats were fed diets with chicken fat and fish oil as sources of fatty acids. In one diet, part of the fish oil was replaced by safflower oil, resulting in two diets with ω6:ω3 PUFA ratios of 10:1 and 40:1. This double-blinded study in two groups of seven cats revealed that dietary fatty acids influence the composition of plasma cholesteryl esters and plasma levels of inflammatory cytokines. The diet with the 10:1 ratio lowered PGD(2) , PGE(2) and LTB(4) plasma levels significantly, compared to the diet with the 40:1 ratio (p = 0.05, p = 0.04, and p = 0.02 respectively). However, feeding diets with dietary ω6:ω3 PUFA ratios of 10:1 and 40:1, given to cats with FCGS for 4 weeks after extraction of all premolars and molars, did not alter the degree of inflammation or wound healing.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. r.j.corbee@uu.nl
authors.forename: R J
authors.initials: RJ
authors.lastname: Corbee
authors.forename: H E
authors.initials: HE
authors.lastname: Booij-Vrieling
authors.forename: C H A
authors.initials: CH
authors.lastname: van de Lest
authors.forename: L C
authors.initials: LC
authors.lastname: Penning
authors.forename: M A
authors.initials: MA
authors.lastname: Tryfonidou
authors.forename: F M
authors.initials: FM
authors.lastname: Riemers
authors.forename: H A W
authors.initials: HA
authors.lastname: Hazewinkel
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D002371:Cat Diseases / Q000628:therapy*; D002415:Cats; D002908:Chronic Disease; D004032:Diet / Q000662:veterinary*; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005260:Female; D005891:Gingivitis / Q000628:therapy / Q000662:veterinary*; D007249:Inflammation / Q000178:diet therapy / Q000662:veterinary*; D008297:Male; D013280:Stomatitis / Q000628:therapy / Q000662:veterinary*; D014081:Tooth Extraction / Q000662:veterinary; D014945:Wound Healing / Q000502:physiology
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6