title: Endopancreatic bile duct cholangiocarcinoma in a patient with peutz-jeghers syndrome.
abstract: Peutz-Jeghers syndrome is a rare autosomal dominant inherited disease characterized by a special type of hamartomatous gastrointestinal polyps combined with mucocutaneous melanin pigmentations. Patients with the syndrome have a high risk of developing neoplasia, with colon, small bowel, and stomach being the most common gastrointestinal sites. Herein, we present the occurrence of a rare tumor in patients with Peutz-Jeghers syndrome; a cholangiocarcinoma of the endopancreatic bile duct. A minireview is also presented. It can be concluded that cholangiocarcinoma remains a possible diagnosis in PJS patients, as in others that present with biliary obstruction. PJS patients may be at higher risk than others in view of their propensity for malignancy.
authors.affiliation: 3rd Department of Surgery, Attikon University Hospital, University of Athens Medical School, 1 Rimini Street, Chaidari, 12462 Athens, Greece.
authors.forename: Alexandros K
authors.initials: AK
authors.lastname: Charalabopoulos
authors.forename: Sylvia P
authors.initials: SP
authors.lastname: Krivan
authors.forename: Nikolas A
authors.initials: NA
authors.lastname: Machairas
authors.forename: Evangelos P
authors.initials: EP
authors.lastname: Misiakos
authors.forename: Anastasios N
authors.initials: AN
authors.lastname: Machairas