title: Optimized linear prediction for radial sampled multidimensional NMR experiments.
abstract: Radial sampling in multidimensional NMR experiments offers greatly decreased acquisition times while also providing an avenue for increased sensitivity. Digital resolution remains a concern and depends strongly upon the extent of sampling of individual radial angles. Truncated time domain data leads to spurious peaks (artifacts) upon FT and 2D FT. Linear prediction is commonly employed to improve resolution in Cartesian sampled NMR experiments. Here, we adapt the linear prediction method to radial sampling. Significantly more accurate estimates of linear prediction coefficients are obtained by combining quadrature frequency components from the multiple angle spectra. This approach results in significant improvement in both resolution and removal of spurious peaks as compared to traditional linear prediction methods applied to radial sampled data. The 'averaging linear prediction' (ALP) method is demonstrated as a general tool for resolution improvement in multidimensional radial sampled experiments.
authors.affiliation: Graduate Group in Biochemistry & Molecular Biophysics, Department of Biochemistry & Biophysics, University of Pennsylvania, Philadelphia, PA 19104-6059, United States.
authors.forename: John M
authors.initials: JM
authors.lastname: Gledhill
authors.forename: Vignesh
authors.initials: V
authors.lastname: Kasinath
authors.forename: A Joshua
authors.initials: AJ
authors.lastname: Wand
mesh_terms: D000465:Algorithms; D016477:Artifacts; D002247:Carbon Isotopes / Q000737:chemistry; D003627:Data Interpretation, Statistical; D005544:Forecasting; D006801:Humans; D007202:Indicators and Reagents; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009587:Nitrogen Isotopes / Q000737:chemistry; D012815:Signal Processing, Computer-Assisted; D025801:Ubiquitin / Q000737:chemistry
chemical_list: D002247:Carbon Isotopes; D007202:Indicators and Reagents; D009587:Nitrogen Isotopes; D025801:Ubiquitin