title: Hantavirus pulmonary syndrome, United States, 1993-2009.
abstract: Hantavirus pulmonary syndrome (HPS) is a severe respiratory illness identified in 1993. Since its identification, the Centers for Disease Control and Prevention has obtained standardized information about and maintained a registry of all laboratory-confirmed HPS cases in the United States. During 1993-2009, a total of 510 HPS cases were identified. Case counts have varied from 11 to 48 per year (case-fatality rate 35%). However, there were no trends suggesting increasing or decreasing case counts or fatality rates. Although cases were reported in 30 states, most cases occurred in the western half of the country; annual case counts varied most in the southwestern United States. Increased hematocrits, leukocyte counts, and creatinine levels were more common in HPS case-patients who died. HPS is a severe disease with a high case-fatality rate, and cases continue to occur. The greatest potential for high annual HPS incidence exists in the southwestern United States.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA. aho3@cdc.gov
authors.forename: Adam
authors.initials: A
authors.lastname: MacNeil
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Ksiazek
authors.forename: Pierre E
authors.initials: PE
authors.lastname: Rollin
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D003404:Creatinine / Q000032:analysis; D003710:Demography; D004197:Disease Reservoirs / Q000821:virology; D005260:Female; D006476:Orthohantavirus / Q000502:physiology*; D018804:Hantavirus Pulmonary Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000208:ethnology / Q000401:mortality / Q000503:physiopathology / Q000635:transmission; D006400:Hematocrit; D006801:Humans; D015994:Incidence; D007198:Indians, North American / Q000706:statistics & numerical data; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012042:Registries; D012189:Retrospective Studies; D012377:Rodentia / Q000821:virology; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data
chemical_list: D003404:Creatinine