title: Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography.
abstract: OBJECTIVE
  We evaluated the diagnostic accuracy of attenuation corrected nuclear myocardial perfusion imaging (MPI) with a novel hybrid single photon emission computed tomography (SPECT)/CT device consisting of an ultrafast dedicated cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors integrated onto a multislice CT scanner to detect coronary artery disease (CAD). Invasive coronary angiography served as the standard of reference.
  
  
  METHODS
  The study population included 66 patients (79% men; mean age 63 ± 11 years) who underwent 1-day (99m)Tc-tetrofosmin pharmacological stress/rest examination and angiography within 3 months. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as accuracy of the CT X-ray based attenuation corrected CZT MPI for detection of CAD (≥ 50% luminal narrowing) was calculated on a per-patient basis.
  
  
  RESULTS
  The prevalence of angiographic CAD in the study population was 82%. Sensitivity, specificity, PPV, NPV and accuracy were 87, 67, 92, 53 and 83%, respectively.
  
  
  CONCLUSIONS
  In this first report on CZT SPECT/CT MPI comparison versus angiography we confirm a high accuracy for detection of angiographically documented CAD.
authors.affiliation: Department of Radiology, Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Fiechter
authors.forename: Jelena R
authors.initials: JR
authors.lastname: Ghadri
authors.forename: Silke M
authors.initials: SM
authors.lastname: Kuest
authors.forename: Aju P
authors.initials: AP
authors.lastname: Pazhenkottil
authors.forename: Mathias
authors.initials: M
authors.lastname: Wolfrum
authors.forename: Rene N
authors.initials: RN
authors.lastname: Nkoulou
authors.forename: Robert
authors.initials: R
authors.lastname: Goetti
authors.forename: Oliver
authors.initials: O
authors.lastname: Gaemperli
authors.forename: Philipp A
authors.initials: PA
authors.lastname: Kaufmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002104:Cadmium; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000295:instrumentation* / Q000592:standards; D055414:Myocardial Perfusion Imaging / Q000295:instrumentation* / Q000592:standards; D049268:Positron-Emission Tomography; D012015:Reference Standards; D012680:Sensitivity and Specificity; D013691:Tellurium; D014057:Tomography, X-Ray Computed; D015032:Zinc
chemical_list: C474490:CdZnTe; D002104:Cadmium; D015032:Zinc; D013691:Tellurium