title: Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma: a single institutional experience and literature review.
abstract: Plasmablastic lymphoma (PBL) is a rare aggressive B-cell lymphoproliferative disorder. HIV-negative PBL has not been extensively reported. Nine HIV-negative PBL patients evaluated at Moffitt Cancer Center were studied. Eight patients had extranodal diseases. All patients were treated with CHOP or hyper-CVAD. Responses were observed in 8 cases (7 complete, 1 partial responses). Four patients underwent consolidation with autologous hematopoietic stem cell transplant (HSCT) in first complete remission (CR1). At median follow-up of 23.9 months, 7 patients were alive and 5 were disease-free. Aggressive induction chemotherapy and consolidation with autologous HSCT in CR1 might be considered for patients with HIV-negative PBL.
authors.affiliation: Department of Hematology and Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Jijun.liu@moffitt.org
authors.forename: Jane Jijun
authors.initials: JJ
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Ernesto
authors.initials: E
authors.lastname: Ayala
authors.forename: Teresa
authors.initials: T
authors.lastname: Field
authors.forename: Jose L
authors.initials: JL
authors.lastname: Ochoa-Bayona
authors.forename: Lia
authors.initials: L
authors.lastname: Perez
authors.forename: Celeste M
authors.initials: CM
authors.lastname: Bello
authors.forename: Paul A
authors.initials: PA
authors.lastname: Chervenick
authors.forename: Salvador
authors.initials: S
authors.lastname: Bruno
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Cultrera
authors.forename: Rachid C
authors.initials: RC
authors.lastname: Baz
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Kharfan-Dabaja
authors.forename: Jyotishankar
authors.initials: J
authors.lastname: Raychaudhuri
authors.forename: Eduardo M
authors.initials: EM
authors.lastname: Sotomayor
authors.forename: Lubomir
authors.initials: L
authors.lastname: Sokol
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000453:epidemiology; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome