title: Uricaemia as a cardiovascular events risk factor in hypertension: the role of interval training programme in its downregulation.
abstract: OBJECTIVE
  Elevated serum uric acid is considered to be positively associated with cardiovascular event risk factor in hypertension. Also, the positive role of exercise in the management of Hypertension has been well and long established. However the relationship between serum uric acid (SUA) level and hypertensive management particularly in non pharmacological technique is ambiguous and unclear. Therefore the purpose of the present study was to determine the effect of interval training programme on serum uric acid level and cardiovascular parameters in male subjects with hypertension.
  
  
  METHODS
  Two hundred and forty five male patients with mild to moderate (systolic blood pressure [SBP] between 140-180 and diastolic blood pressure [DBP] between 90-109 mmHg) essential hypertension were age matched and grouped into interval and control groups. The interval (n = 140; 58.90 +/- 7.35 years) group involved in an 8 weeks interval training (60-79% HR max reserve) programme of between 45 minutes to 60 minutes at a work/rest ratio of 1:1 of 6 minutes each, while age-matched controls hypertensive (n = 105; 58.27 +/- 6.24 years) group remain sedentary during this period. Cardiovascular parameters (SBP, DBP and VO2max) and serum uric acid were assessed. Students' t and Pearson correlation tests were used in data analysis.
  
  
  RESULTS
  Findings of the study revealed significant effect of interval training programme on VO2max, SBP, DBP and serum uric acid level at p < 0.05. Also there was significant correlation between changes VO2max and changes in SUA, SBP and DBP.
  
  
  CONCLUSIONS
  It was concluded that interval training programme is an effective non-pharmacological means of downregulation of SUA.
authors.affiliation: Physiotherapy/Physiology Dept, Faculty of Medical Sciences, Jimma University, Ethiopia.
authors.forename: Sikiru
authors.initials: S
authors.lastname: Lamina
authors.forename: Chuba G
authors.initials: CG
authors.lastname: Okoye
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D004311:Double-Blind Method; D015536:Down-Regulation; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D010101:Oxygen Consumption / Q000502:physiology; D012146:Rest; D012307:Risk Factors; D057185:Sedentary Behavior; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid