title: Golgi during development.
abstract: The Golgi is essential for processing proteins and sorting them, as well as plasma membrane components, to their final destinations. Not surprisingly, this organelle, a major compartment of the secretory pathway, is an important venue for regulating many aspects of development in both invertebrates and vertebrates. Through its role as a site for protein cleavage and glycosylation as well as through changes in its spatial organization and secretory trafficking, the Golgi exerts highly specific effects on cellular differentiation and morphogenesis by spatially and temporally constraining developmental pathways.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhong
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D006056:Golgi Apparatus / Q000502:physiology*; D008954:Models, Biological; D046188:Protein Modification, Translational / Q000502:physiology*; D051880:Receptors, Notch / Q000378:metabolism; D055571:Secretory Pathway / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D051880:Receptors, Notch