title: A modular synthesis of salvileucalin B structural domains.
abstract: A modular strategy leading to the salvileucalin B core structure has been accomplished. The developed synthetic strategy featured a bioinspired intramolecular Diels-Alder reaction to construct domain "A", REDOX chemistry to functionalize domain "B", and a palladium-mediated cross-coupling to install domain "C". This flexible approach should facilitate further chemical and biological investigations of this fascinating class of compounds.
authors.affiliation: Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, #03-08, Singapore 138667.
authors.forename: Chih-Chung
authors.initials: CC
authors.lastname: Tseng
authors.forename: Hanfeng
authors.initials: H
authors.lastname: Ding
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.forename: Yucui
authors.initials: Y
authors.lastname: Guan
authors.forename: David Y-K
authors.initials: DY
authors.lastname: Chen
mesh_terms: D004224:Diterpenes / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry
chemical_list: D004224:Diterpenes; C533291:salvileucalin B; D010165:Palladium