title: The importance of clinical grading of heart failure and other cardiac toxicities during chemotherapy: updating the common terminology criteria for clinical trial reporting.
abstract: Although the use of chemotherapy and targeted therapy has improved the clinical benefit, progression-free survival, and overall survival of various cancers in recent years, old and new toxicities have limited their use. To balance the risk with the benefit of treatment, Common Toxicity Criteria and now Common Terminology Criteria for Adverse Events (CTCAE) have been used by the oncology community for more than 20 years to assess toxicity from cancer treatment. This article details the description and grading of cardiac toxicities reported in association with cancer treatment and the use of CTCAE to assess them.
authors.affiliation: Departments of Medicine, Hematology and Oncology, Ellis Fischel Cancer Center, University of Missouri, 15 Business Loop 70 West, DC 116.71 Columbia, MO 65203, USA.
authors.forename: Akm
authors.initials: A
authors.lastname: Hossain
authors.forename: Alice
authors.initials: A
authors.lastname: Chen
authors.forename: Percy
authors.initials: P
authors.lastname: Ivy
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Lenihan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Kaltman
authors.forename: Wendy
authors.initials: W
authors.lastname: Taddei-Peters
authors.forename: Scot C
authors.initials: SC
authors.lastname: Remick
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000145:classification; D054715:Cardiotoxins / Q000009:adverse effects / Q000145:classification; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control; D064420:Drug-Related Side Effects and Adverse Reactions / Q000145:classification / Q000175:diagnosis / Q000517:prevention & control; D042241:Early Diagnosis; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D018579:Patient Selection; D018570:Risk Assessment / Q000145:classification; D012307:Risk Factors; D012720:Severity of Illness Index; D009626:Terminology as Topic
chemical_list: D000970:Antineoplastic Agents; D054715:Cardiotoxins