title: A hydrogen peroxide based access to qinghaosu (artemisinin).
abstract: Attachment of H(2)O(2) onto the highly hindered quaternary C-12a in an advanced qinghaosu (artemisinin) precursor has been achieved through a facile perhydrolysis of a spiro epoxy ring with the aid of a previously unknown molybdenum species without involving any special equipment or complicated operations. The resultant β-hydroxyhydroperoxide can be further elaborated into qinghaosu, illustrating an entry fundamentally different from the existing ones to this outstanding natural product of great importance in malaria chemotherapy.
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Hong-Dong
authors.initials: HD
authors.lastname: Hao
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.forename: Wei-Bo
authors.initials: WB
authors.lastname: Han
authors.forename: Yikang
authors.initials: Y
authors.lastname: Wu
mesh_terms: D037621:Artemisinins / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D037621:Artemisinins; D004852:Epoxy Compounds; D006861:Hydrogen Peroxide