title: Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments.
abstract: Prepared to self-destruct: when poly(D, L-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO(3) entered the endocytic organelles of a live cell, the NaHCO(3) in the aqueous core reacted with protons that infiltrated from the compartment to generate CO(2) gas. The evolution of CO(2) bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin.
authors.affiliation: Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC.
authors.forename: Cherng-Jyh
authors.initials: CJ
authors.lastname: Ke
authors.forename: Tzu-Yuan
authors.initials: TY
authors.lastname: Su
authors.forename: Hsin-Lung
authors.initials: HL
authors.lastname: Chen
authors.forename: Hao-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Wei-Lun
authors.initials: WL
authors.lastname: Chiang
authors.forename: Po-Chun
authors.initials: PC
authors.lastname: Chu
authors.forename: Younan
authors.initials: Y
authors.lastname: Xia
authors.forename: Hsing-Wen
authors.initials: HW
authors.lastname: Sung
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry; D008247:Lysosomes / Q000737:chemistry* / Q000378:metabolism; D008863:Microspheres; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D017693:Sodium Bicarbonate / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004317:Doxorubicin; D017693:Sodium Bicarbonate