title: Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors.
abstract: Sarcophine (1) is a bioactive cembranoid diterpene isolated from the Red Sea soft coral Sarcophyton glaucum. Previous semisynthesis attempts resulted in decreased or complete loss of 1's anticancer activity. Sarcophine and analogues showed antimigratory activity against breast and prostate cancer cell lines. This encouraged further semisynthestic optimizations to improve its activity and establish a preliminary structure-activity relationship. Eight new and five known semisynthetic analogues were generated. These compounds were evaluated for their ability to inhibit growth, proliferation, and migration of the prostate and breast metastatic cancer cell lines PC-3 and MDA-MB-231, respectively. Most analogues exhibited enhanced antimigratory activity.
authors.affiliation: Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.
authors.forename: Hossam M
authors.initials: HM
authors.lastname: Hassan
authors.forename: Asmaa A
authors.initials: AA
authors.lastname: Sallam
authors.forename: Rabab
authors.initials: R
authors.lastname: Mohammed
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Hifnawy
authors.forename: Diaa T A
authors.initials: DT
authors.lastname: Youssef
authors.forename: Khalid A
authors.initials: KA
authors.lastname: El Sayed
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D037421:Anthozoa / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D054443:Cell Migration Assays; D002464:Cell Migration Inhibition / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D019156:Indian Ocean; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C014804:sarcophine; D015107:4-Butyrolactone