title: Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics.
abstract: Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/β-turn/sheet motif.
authors.affiliation: Department of Chemistry and Laboratory for Molecular Simulation, Texas A&M University, Box 30012, College Station, Texas 77842, United States.
authors.forename: Arjun
authors.initials: A
authors.lastname: Raghuraman
authors.forename: Eunhwa
authors.initials: E
authors.lastname: Ko
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Perez
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Ioerger
authors.forename: Kevin
authors.initials: K
authors.lastname: Burgess
mesh_terms: D008958:Models, Molecular; D057786:Peptidomimetics / Q000138:chemical synthesis / Q000737:chemistry*; D017433:Protein Structure, Secondary; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D057786:Peptidomimetics; D011758:Pyrroles; D011759:Pyrrolidines; C013231:pyrroline; C032519:pyrrolidine