title: Cytokines and T-Lymphocute count in patients in the acute and chronic phases of Bartonella bacilliformis infection in an endemic area in peru: a pilot study.
abstract: Human Bartonellosis has an acute phase characterized by fever and hemolytic anemia, and a chronic phase with bacillary angiomatosis-like lesions. This cross-sectional pilot study evaluated the immunology patterns using pre- and post-treatment samples in patients with Human Bartonellosis. Patients between five and 60 years of age, from endemic areas in Peru, in the acute or chronic phases were included. In patients in the acute phase of Bartonellosis a state of immune peripheral tolerance should be established for persistence of the infection. Our findings were that elevation of the anti-inflammatory cytokine IL-10 and numeric abnormalities of CD4(+) and CD8(+) T-Lymphocyte counts correlated significantly with an unfavorable immune state. During the chronic phase, the elevated levels of IFN-γ and IL-4 observed in our series correlated with previous findings of endothelial invasion of B. henselae in animal models.
authors.affiliation: Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
authors.forename: Erick
authors.initials: E
authors.lastname: Huarcaya
authors.forename: Ivan
authors.initials: I
authors.lastname: Best
authors.forename: Juan
authors.initials: J
authors.lastname: Rodriguez-Tafur
authors.forename: Ciro
authors.initials: C
authors.lastname: Maguiña
authors.forename: Nelson
authors.initials: N
authors.lastname: Solórzano
authors.forename: Julio
authors.initials: J
authors.lastname: Menacho
authors.forename: Douglas
authors.initials: D
authors.lastname: Lopez De Guimaraes
authors.forename: Jose
authors.initials: J
authors.lastname: Chauca
authors.forename: Palmira
authors.initials: P
authors.lastname: Ventosilla
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001474:Bartonella Infections / Q000453:epidemiology / Q000276:immunology*; D045503:Bartonella bacilliformis / Q000276:immunology*; D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010568:Peru / Q000453:epidemiology; D010865:Pilot Projects; D013601:T-Lymphocytes / Q000276:immunology*; D055815:Young Adult
chemical_list: D016207:Cytokines