title: Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.
abstract: Distributions of duplicated sequences from genome self-alignment are characterized, including forward and backward alignments in bacteria and eukaryotes. A Markovian process without auto-correlation should generate an exponential distribution expected from local effects of point mutation and selection on localised function; however, the observed distributions show substantial deviation from exponential form--they are roughly algebraic instead--suggesting a novel kind of long-distance correlation that must be non-local in origin.
authors.affiliation: Physics and Biology Unit, Okinawa Institute of Science and Technology, Kunigami, Okinawa, Japan.
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
authors.forename: Jonathan
authors.initials: J
authors.lastname: Miller
mesh_terms: D019295:Computational Biology; D056916:Segmental Duplications, Genomic / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA / Q000379:methods*