title: Synthesis of aryl aldimines and their activity against fungi of clinical interest.
abstract: Aldimines are aldehyde-derived compounds that contain a C=N group. Besides its broad industrial applications, this class of non-naturally occurring compounds are found to possess antibacterial, antifungal, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Based on this, six aryl aldimines were synthesized from the condensation of aromatic amines with benzaldehydes. The antifungal activities of synthesized compounds were evaluated against nineteen fungal strains that included Candida and Aspergillus species, Cryptococcus neoformans. The aryl aldimines 2-(benzylideneamino)phenol (3) and 4-(benzylideneamino)phenol (8) were the most active compounds against the fungi studied. Compounds 3 and 8 efficiently inhibited the metabolism of C. neoformans mature biofilm.
authors.affiliation: Grupo de Estudos em Química Orgânica e Biológica (GEQOB), Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
authors.forename: Cleiton M
authors.initials: CM
authors.lastname: da Silva
authors.forename: Danielle L
authors.initials: DL
authors.lastname: da Silva
authors.forename: Cleide V B
authors.initials: CV
authors.lastname: Martins
authors.forename: Maria A
authors.initials: MA
authors.lastname: de Resende
authors.forename: Esther S
authors.initials: ES
authors.lastname: Dias
authors.forename: Thais F F
authors.initials: TF
authors.lastname: Magalhães
authors.forename: Letícia P
authors.initials: LP
authors.lastname: Rodrigues
authors.forename: Adão A
authors.initials: AA
authors.lastname: Sabino
authors.forename: Rosemeire B
authors.initials: RB
authors.lastname: Alves
authors.forename: Ângelo
authors.initials: Â
authors.lastname: de Fátima
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001597:Benzylidene Compounds / Q000737:chemistry*; D018441:Biofilms / Q000187:drug effects; D002175:Candida / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D001597:Benzylidene Compounds; D010636:Phenols