title: Conjugate reduction and reductive aldol cyclization of α,β-unsaturated thioesters catalyzed by (BDP)CuH.
abstract: A conjugate reduction of α,β-unsaturated thioesters catalyzed by copper hydride using PMHS as stoichiometric reductant has been developed. 1,2-Bis(diphenylphosphino)benzene (BDP) was the most effective ligand for this reduction. Saturated thioesters could be produced in excellent yields when the substituent on the thiol is not sterically-demanding. This protocol was applied to induce the reductive aldol cyclization of keto-enethioates, which could offer β-hydroxythioesters in moderate to good yields.
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.
authors.forename: Ninglin
authors.initials: N
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Ou
authors.forename: Michel
authors.initials: M
authors.lastname: Miesch
authors.forename: Pauline
authors.initials: P
authors.lastname: Chiu