title: Antinociceptive activity of the chloroform fraction of Dioclea virgata (Rich.) Amshoff (Fabaceae) in mice.
abstract: Acute treatment with the chloroform fraction of Dioclea virgata (Rich.) Amshoff (CFDv) in mice produced decreased ambulation and sedation in the behavioral pharmacological screening. Doses of 125 and 250 mg/kg CFDv decreased latency of sleep onset in the test of sleeping time potentiation. In the open field, animals treated with CFDv reduced ambulation and rearing (250 mg/kg), as well as defecation (125; 250 mg/kg). Regarding the antinociceptive activity, CFDv (125, 250, 500 mg/kg) increased latency to first writhing and decreased the number of writhings induced by acetic acid. In the formalin test, CFDv (250 mg/kg) decreased paw licking time in the first and second phases indicating antinociceptive activity that can be mediated both peripherally and at the central level. CFDv did not affect motor coordination until 120 minutes after treatment. CFDv shows psychopharmacological effects suggestive of CNS-depressant drugs with promising antinociceptive activity.
authors.affiliation: Laboratory of Pharmaceutical Technology, Center of Health Sciences, Federal University of Paraíba-UFPB, João Pessoa, PB, Brazil.
authors.forename: Vanine Gomes
authors.initials: VG
authors.lastname: Mota
authors.forename: Fabíola Lélis
authors.initials: FL
authors.lastname: de Carvalho
authors.forename: Liana Clébia Soares Lima
authors.initials: LC
authors.lastname: de Morais
authors.forename: Jnanabrata
authors.initials: J
authors.lastname: Bhattacharyya
authors.forename: Reinaldo Nóbrega
authors.initials: RN
authors.lastname: de Almeida
authors.forename: Jacicarlos Lima
authors.initials: JL
authors.lastname: de Alencar
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005591:Chemical Fractionation; D002725:Chloroform / Q000737:chemistry*; D052598:Dioclea / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D010424:Pentobarbital; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D012890:Sleep / Q000187:drug effects; D018709:Statistics, Nonparametric
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D002725:Chloroform; D010424:Pentobarbital