title: Traumatic ulcerative granuloma with stromal eosinophilia: report of a case and literature review.
abstract: Traumatic eosinophilic granuloma with stromal eosinophilia is a rare entity that affects the oral mucosa and has a controversial etiologic pathogenesis. Histologically, these lesions are characterized by a dense and deeply infiltrative lymphoproliferation showing epitheliotropic characteristics and massive eosinophilia. Frequently, a population of mitotically active, atypical mononuclear cells can be noted. This report describes a case of traumatic eosinophilic granuloma with stromal eosinophilia in the floor of the mouth of an 88-year-old man. The phenotypic and genotypic profiles of the inflammatory infiltrate and large atypical mononuclear cells, using immunohistochemical and polymerase chain reaction-based molecular analysis, were analyzed.
authors.affiliation: Department of Basic Sciences, Dental School, University of Athens, Athens, Greece. ihatzist@med.uoa.gr
authors.forename: Ioulia
authors.initials: I
authors.lastname: Chatzistamou
authors.forename: Ipatia
authors.initials: I
authors.lastname: Doussis-Anagnostopoulou
authors.forename: George
authors.initials: G
authors.lastname: Georgiou
authors.forename: Harry
authors.initials: H
authors.lastname: Gkilas
authors.forename: George
authors.initials: G
authors.lastname: Prodromidis
authors.forename: Maria
authors.initials: M
authors.lastname: Andrikopoulou
authors.forename: Alexandra
authors.initials: A
authors.lastname: Sklavounou
mesh_terms: D000369:Aged, 80 and over; D004247:DNA / Q000032:analysis; D004803:Eosinophilic Granuloma / Q000175:diagnosis* / Q000473:pathology; D004804:Eosinophils / Q000473:pathology; D005500:Follow-Up Studies; D015321:Gene Rearrangement / Q000235:genetics; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics; D050438:Genes, Immunoglobulin Heavy Chain / Q000235:genetics; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007150:Immunohistochemistry; D008297:Male; D009059:Mouth Diseases / Q000175:diagnosis* / Q000473:pathology; D009060:Mouth Floor / Q000473:pathology; D009061:Mouth Mucosa / Q000293:injuries*; D019226:Oral Ulcer / Q000175:diagnosis* / Q000473:pathology; D016133:Polymerase Chain Reaction; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D017154:Stromal Cells / Q000473:pathology
chemical_list: D007135:Immunoglobulin Variable Region; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D004247:DNA