title: Transitory increase in creatinine levels after parathyroidectomy: evidence of another action of the parathyroid glands?
abstract: OBJECTIVE
  Little information is available on glomerular function changes after surgical treatment of primary hyperparathyroidism. The acute effects of some head and neck operations on renal function were studied.
  
  
  METHODS
  Retrospective analysis of changes in creatinine levels and estimated glomerular filtration rate (eGFR) after surgery. Preoperative values were compared with values available until 72 hours after the operation.
  
  
  RESULTS
  In tertiary hyperparathyroidism, mean preoperative and postoperative eGFR values were 57.7 mL/min and 40.8 mL/min (p < 0.0001), respectively. A similar decrease was observed after parathyroidectomy for primary hyperparathyroidism, from 85.4 mL/min to 64.3 mL/min (p < 0.0001). After major head and neck procedures, there was a slight increase in eGFR (from 94.3 mL/min to 105.4 mL/min, p = 0.002).
  
  
  CONCLUSIONS
  Parathyroidectomy may be followed by a transient decrease in eGFR that is not often observed in other head and neck operations.
authors.affiliation: Head and Neck Surgery, Department of Surgery, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil. fabiomonte@uol.com.br
authors.forename: Fábio M
authors.initials: FM
authors.lastname: Montenegro
authors.forename: Lenine G
authors.initials: LG
authors.lastname: Brandão
authors.forename: Gustavo F
authors.initials: GF
authors.lastname: Ferreira
authors.forename: Delmar M
authors.initials: DM
authors.lastname: Lourenço
authors.forename: Regina M
authors.initials: RM
authors.lastname: Martin
authors.forename: Malebranche B
authors.initials: MB
authors.lastname: Cunha-Neto
authors.forename: Claudia B
authors.initials: CB
authors.lastname: Helou
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Toledo
authors.forename: Anói C
authors.initials: AC
authors.lastname: Cordeiro
authors.forename: Luiz E
authors.initials: LE
authors.lastname: Ianhez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002648:Child; D003404:Creatinine / Q000097:blood*; D004812:Epidemiologic Methods; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016105:Parathyroidectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000097:blood; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003404:Creatinine