title: Chitosan-sodium lauryl sulfate nanoparticles as a carrier system for the in vivo delivery of oral insulin.
abstract: The present work explores the possibility of formulating an oral insulin delivery system using nanoparticulate complexes made from the interaction between biodegradable, natural polymer called chitosan and anionic surfactant called sodium lauryl sulfate (SLS). The interaction between chitosan and SLS was confirmed by Fourier transform infrared spectroscopy. The nanoparticles were prepared by simple gelation method under aqueous-based conditions. The nanoparticles were stable in simulated gastric fluids and could protect the encapsulated insulin from the GIT enzymes. Additionally, the in vivo results clearly indicated that the insulin-loaded nanoparticles could effectively reduce the blood glucose level in a diabetic rat model. However, additional formulation modifications are required to improve insulin oral bioavailability.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Gezira University, Medani, Sudan.
authors.forename: Amani
authors.initials: A
authors.lastname: Elsayed
authors.forename: Mayyas
authors.initials: M
authors.lastname: Al-Remawi
authors.forename: Nidal
authors.initials: N
authors.lastname: Qinna
authors.forename: Asim
authors.initials: A
authors.lastname: Farouk
authors.forename: Khaldoun A
authors.initials: KA
authors.lastname: Al-Sou'od
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Badwan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D001786:Blood Glucose / Q000187:drug effects; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D016503:Drug Delivery Systems / Q000379:methods; D007328:Insulin / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D001786:Blood Glucose; D007328:Insulin; D012967:Sodium Dodecyl Sulfate; D048271:Chitosan