title: Non-hemolytic α-AApeptides as antimicrobial peptidomimetics.
abstract: We report a new class of peptide mimetics, α-AApeptides, that display broad-spectrum activity against both Gram-negative and Gram-positive bacteria and fungi. With non-hemolytic activity, resistance to protease hydrolysis, and easy sequence programmability, α-AApeptides may emerge as a novel class of antibiotics.
authors.affiliation: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
authors.forename: Shruti
authors.initials: S
authors.lastname: Padhee
authors.forename: Yaogang
authors.initials: Y
authors.lastname: Hu
authors.forename: Youhong
authors.initials: Y
authors.lastname: Niu
authors.forename: Ge
authors.initials: G
authors.lastname: Bai
authors.forename: Haifan
authors.initials: H
authors.lastname: Wu
authors.forename: Frankie
authors.initials: F
authors.lastname: Costanza
authors.forename: Leigh
authors.initials: L
authors.lastname: West
authors.forename: Lacey
authors.initials: L
authors.lastname: Harrington
authors.forename: Lindsey N
authors.initials: LN
authors.lastname: Shaw
authors.forename: Chuanhai
authors.initials: C
authors.lastname: Cao
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cai
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D057786:Peptidomimetics / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D057786:Peptidomimetics