title: Anti-inflammatory amino acid derivatives from the ascidian Herdmania momus.
abstract: Four new amino acid derivatives, herdmanines A-D (1-4), were isolated from the marine ascidian Herdmania momus. Herdmanines A-C contain the unusual D-form of arginine. Compounds 3 and 4 had a moderate suppressive effect on the production of NO, with IC₅₀ values of 96 and 9 μM, respectively. These compounds were found to inhibit the mRNA expression of iNOS. The inhibitory activities on the production and mRNA expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 were evaluated.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors.forename: Jian Lin
authors.initials: JL
authors.lastname: Li
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Han
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Yoo
authors.forename: Sook
authors.initials: S
authors.lastname: Shin
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Zheng
authors.initials: Z
authors.lastname: Cui
authors.forename: Huayue
authors.initials: H
authors.lastname: Li
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001120:Arginine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D021902:Enterobacter aerogenes / Q000187:drug effects; D016972:Enterobacter cloacae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D020382:Interleukin-18 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007723:Korea; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects / Q000235:genetics; D019906:Nuclear Magnetic Resonance, Biomolecular; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics; D012486:Salmonella typhimurium / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D020382:Interleukin-18; D015850:Interleukin-6; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D001120:Arginine; D052247:Nitric Oxide Synthase Type II