title: Synthesis and antiglycation potentials of bergenin derivatives.
abstract: Bergenin (1), major bioactive compound isolated from methanolic extract of Mallotus philippinensis, displayed moderate AGE inhibition activity (IC(50)=186.73 μM). A series of derivatives of bergenin (3a-k) containing variety of aromatic acids were synthesized under mild conditions by modification of sugar part. Selective esterification of hydroxyl groups on the sugar part enhanced antiglycation potential of bergenin. Compounds 3j and 3k exhibited potent antiglycation activity with the IC(50) values of 60.75 and 12.28 μM, respectively.
authors.affiliation: Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500607, India.
authors.forename: T
authors.initials: T
authors.lastname: Vijaya Kumar
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Tiwari
authors.forename: A
authors.initials: A
authors.lastname: Robinson
authors.forename: K
authors.initials: K
authors.lastname: Suresh Babu
authors.forename: R
authors.initials: R
authors.lastname: Sateesh Chandra Kumar
authors.forename: D
authors.initials: D
authors.lastname: Anand Kumar
authors.forename: A
authors.initials: A
authors.lastname: Zehra
authors.forename: J
authors.initials: J
authors.lastname: Madhusudna Rao
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D036461:Mallotus Plant / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D001578:Benzopyrans; D017127:Glycation End Products, Advanced; C006741:bergenin