title: A facile preparation of trisubstituted amino-furan and -thiophene derivatives.
abstract: β-Alkylation of amino-furan and -thiophene heterocycles is described through metal-, acid- and base-free carbon-carbon bond formation. The ability of both heterocycles to undergo selective β-alkylation is compared by mean of experimental and theoretical data. The presence of chiral amine substituents induced the diastereoselective generation of the newly formed additional stereocenter.
authors.affiliation: Université de Versailles-St-Quentin (UVSQ), Institut Lavoisier de Versailles (ILV) UMR CNRS 8180, 45 Avenue des Etats-Unis, 78035, Versailles Cedex, France.
authors.forename: Raouf
authors.initials: R
authors.lastname: Medimagh
authors.forename: Sylvain
authors.initials: S
authors.lastname: Marque
authors.forename: Damien
authors.initials: D
authors.lastname: Prim
authors.forename: Saber
authors.initials: S
authors.lastname: Chatti