title: Study of the 12q13 region in nonsyndromic cleft lip with or without cleft palate.
abstract: The 12q13 region has been suggested as a candidate locus for orofacial cleft by different investigators. In the present study we tested the region for linkage with non syndromic cleft lip with or without cleft palate in a collection of 39 Italian multigenerational families, using microsatellite markers. No evidence of linkage was detected between the marker map and NSCLP under different mode of inheritance nor with a nonparametric method. Formal level of linkage exclusion, were obtained for each point of the map. Genetic heterogeneity and the different impact of the candidate locus among populations could explain conflicting results obtained in different studies.
authors.affiliation: Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Martinelli
authors.forename: F
authors.initials: F
authors.lastname: Carinci
authors.forename: P G
authors.initials: PG
authors.lastname: Morselli
authors.forename: A
authors.initials: A
authors.lastname: Palmieri
authors.forename: A
authors.initials: A
authors.lastname: Girardi
authors.forename: L
authors.initials: L
authors.lastname: Clauser
authors.forename: G
authors.initials: G
authors.lastname: Spinelli
authors.forename: L
authors.initials: L
authors.lastname: Scapoli
mesh_terms: D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D007558:Italy; D018895:Microsatellite Repeats / Q000235:genetics; D044465:White People / Q000235:genetics