title: Multi-scale correlation structure of gene expression in the brain.
abstract: The mammalian brain is best understood as a multi-scale hierarchical neural system, in the sense that connection and function occur on multiple scales from micro to macro. Modern genomic-scale expression profiling can provide insight into methodologies that elucidate this architecture. We present a methodology for understanding the relationship of gene expression and neuroanatomy based on correlation between gene expression profiles across tissue samples. A resulting tool, NeuroBlast, can identify networks of genes co-expressed within or across neuroanatomic structures. The method applies to any data modality that can be mapped with sufficient spatial resolution, and provides a computation technique to elucidate neuroanatomy via patterns of gene expression on spatial and temporal scales. In addition, from the perspective of spatial location, we discuss a complementary technique that identifies gene classes that contribute to defining anatomic patterns.
authors.affiliation: Allen Institute for Brain Science, 551 N. 34th Street, Seattle, WA 98103, USA. mikeh@alleninstitute.org
authors.forename: Mike
authors.initials: M
authors.lastname: Hawrylycz
authors.forename: Lydia
authors.initials: L
authors.lastname: Ng
authors.forename: Damon
authors.initials: D
authors.lastname: Page
authors.forename: John
authors.initials: J
authors.lastname: Morris
authors.forename: Chris
authors.initials: C
authors.lastname: Lau
authors.forename: Sky
authors.initials: S
authors.lastname: Faber
authors.forename: Vance
authors.initials: V
authors.lastname: Faber
authors.forename: Susan
authors.initials: S
authors.lastname: Sunkin
authors.forename: Vilas
authors.initials: V
authors.lastname: Menon
authors.forename: Ed
authors.initials: E
authors.lastname: Lein
authors.forename: Allan
authors.initials: A
authors.lastname: Jones
mesh_terms: D000465:Algorithms; D000818:Animals; D001271:Atlases as Topic; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001923:Brain Chemistry / Q000235:genetics*; D057225:Data Mining / Q000379:methods*; D030541:Databases, Genetic; D015870:Gene Expression / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D014365:Tryptophan Hydroxylase / Q000235:genetics / Q000502:physiology
chemical_list: D009419:Nerve Tissue Proteins; C487802:Tph2 protein, mouse; D014365:Tryptophan Hydroxylase