title: Radiation-induced sarcoma in bronchial stump after thoracic radiation therapy for small-cell lung cancer.
abstract: We report a rare case of radiation-induced sarcoma (RIS) that arose in the right bronchial stump, 8 years after right pneumonectomy followed by adjuvant chemotherapy and thoracic radiotherapy for a localized small-cell lung cancer. The patient was treated in 2002 with 6 MV X-ray irradiation in a total dose of 60 Gy. Eight years after the end of radiotherapy, he presented with an undifferentiated high-grade pleomorphic sarcoma. Although an increased rate of soft tissue sarcoma has been reported after radiotherapy for some solid cancers or lymphomas, to our knowledge, this is the first report of RIS related to small-cell lung cancer.
authors.affiliation: Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, Republic of China. zhu.hong70@gmail.com
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: XiaoGe
authors.initials: X
authors.lastname: Zhou
authors.forename: ChangSheng
authors.initials: C
authors.lastname: Wang
mesh_terms: D001984:Bronchial Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D003131:Combined Modality Therapy; D006801:Humans; D053552:Keratin-7 / Q000378:metabolism; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D011878:Radiotherapy / Q000009:adverse effects; D012509:Sarcoma / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D014746:Vimentin / Q000378:metabolism
chemical_list: C081876:CKAP4 protein, human; D053552:Keratin-7; D008565:Membrane Proteins; D014746:Vimentin