title: Interfacial properties of hydrophilized poly(lactic-co-glycolic acid) layers with various thicknesses.
abstract: Biodegradable polyesters such as poly(lactic-co-glycolic acid) copolymers (PLGA) are preferred materials for drug carrier systems although their surface hydrophobicity greatly limits their use in controlled drug delivery. PLGA thin films on a solid support blended with PEG-containing compound (Pluronic) were used as model systems to study the interfacial interactions with aqueous media. Degree of surface hydrophilization was assessed by wettability, and X-ray photoelectron spectroscopy (XPS) measurements. Protein adsorption behavior was investigated by in situ spectroscopic ellipsometry. The degree of protein adsorption showed a good correlation with the hydrophilicity, and surface composition. Unexpectedly, the layer thickness was found to have a great impact on the interfacial characteristics of the polymer films in the investigated regime (20-200 nm). Thick layers presented higher hydrophilicity and great resistance to protein adsorption. That special behavior was explained as the result of the swelling of the polymer film combined with the partial dissolution of Pluronic from the layer. This finding might promote the rational design of surface modified biocompatible nanoparticles.
authors.affiliation: Laboratory of Interfaces and Nanostructures, Institute of Chemistry, Loránd Eötvös University, Budapest 112, P.O. Box 32, H-1518, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Gyulai
authors.forename: Cs B
authors.initials: CB
authors.lastname: Pénzes
authors.forename: M
authors.initials: M
authors.lastname: Mohai
authors.forename: T
authors.initials: T
authors.lastname: Lohner
authors.forename: P
authors.initials: P
authors.lastname: Petrik
authors.forename: S
authors.initials: S
authors.lastname: Kurunczi
authors.forename: É
authors.initials: É
authors.lastname: Kiss
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011506:Proteins / Q000737:chemistry; D017155:Wettability
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D011506:Proteins; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid