title: Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis.
abstract: OBJECTIVE
  Impaired glucose tolerance based on 2-h glucose levels is more predictive of future cardiovascular disease and more sensitive in detecting earlier diabetes compared to impaired fasting glucose. However, the 1-h OGTT may be even more sensitive than the 2-h. We assessed the relative value of 1-h OGTT by exploring its relationship with adiposity and other measures of glucose homeostasis.
  
  
  RESULTS
  Ninety four overweight/obese individuals free of diabetes and major cardiovascular conditions were included in the analyses. We adjusted for age, gender, smoking status and physical activity. One-h OGTT showed similar partial correlations with fasting glucose and 2-h OGTT (r=0.60 and 0.64 respectively). Fasting glucose, fasting insulin and HOMA correlated better with 1-h OGTT (r=0.60, 0.47 and 0.52) than with 2-h OGTT (r=0.50, 0.41, and 0.45). BMI and waist circumference also showed stronger correlation with 1-h (r=0.31, 0.29), compared to 2-h OGTT (r=0.16, 0.16) or fasting glucose (r=0.23, 0.22). Metabolic syndrome was associated similarly with 1-h and 2-h OGTT.
  
  
  CONCLUSIONS
  The 1-h OGTT correlates well with both fasting glucose and 2-h OGTT and shows similar or higher associations with obesity measures. The 1-h OGTT has potential utility in epidemiologic studies.
authors.affiliation: University of Puerto Rico, Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, PO Box 365067, San Juan PR 00936, Puerto Rico; Harvard School of Public Health, Department of Epidemiology, 677 Huntington Avenue, Boston, MA 02115, United States. Electronic address: kaumudi.joshipura@upr.edu.
authors.forename: K J
authors.initials: KJ
authors.lastname: Joshipura
authors.affiliation: University of Puerto Rico, Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, PO Box 365067, San Juan PR 00936, Puerto Rico. Electronic address: oelisoa.andriankaja@gmail.com.
authors.forename: M O
authors.initials: MO
authors.lastname: Andriankaja
authors.affiliation: Harvard School of Public Health, Department of Epidemiology, 677 Huntington Avenue, Boston, MA 02115, United States. Electronic address: frank.hu@channing.harvard.edu.
authors.forename: F B
authors.initials: FB
authors.lastname: Hu
authors.affiliation: Birmingham-Atlanta VA Geriatric Research, Education and Clinical Center (GRECC), University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-2041, USA; University of Puerto Rico, Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, PO Box 365067, San Juan PR 00936, Puerto Rico. Electronic address: CRitchie@aging.uab.edu.
authors.forename: C S
authors.initials: CS
authors.lastname: Ritchie
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D015992:Body Mass Index; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods / Q000592:standards*; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis; D008875:Middle Aged; D013997:Time Factors; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin