title: [Metabolic issues of ischemia induced myocardial dysfunction].
abstract: Myocardial ischemia represents most common cause of necrosis of cardiomyocytes, cardio sclerosis and heart failure. Main clinical manifestation of myocardial ischemia is systolic and/or diastolic dysfunction. It has been shown, that local disturbance of myocardial contractility is not always determined by cell necrosis and cardio sclerosis, as improvement of coronary perfusion may lead to restoration of contractile function of myocardium. Present review outlines aspects of phenomenon of ischemic preconditioning, hibernation and myocardial stunning (so called new ischemic syndromes) that are suggested to be determinants of ischemia induced myocardial dysfunction. No-reflow (Less known type of myocardial stunning) is considered also. However, further studies of molecular mechanisms of ischemic syndromes are necessary for development of new methods of protection of myocardium against ischemic or reperfusion injury.
authors.forename: N D
authors.initials: ND
authors.lastname: Mamamtavrishvili
authors.forename: N S
authors.initials: NS
authors.lastname: Sharashidze
authors.forename: R I
authors.initials: RI
authors.lastname: Abashidze
authors.forename: A A
authors.initials: AA
authors.lastname: Kvirkveliia
mesh_terms: D006333:Heart Failure / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology*; D015425:Myocardial Reperfusion; D017682:Myocardial Stunning / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D054318:No-Reflow Phenomenon / Q000503:physiopathology; D012598:Sclerosis / Q000473:pathology