title: Epigenetic features that regulate IgH locus recombination and expression.
abstract: Precisely regulated rearrangements that yield imprecise recombination junctions are hallmarks of antigen receptor gene assembly. At the immunoglobulin heavy chain (IgH) gene locus this is initiated by rearrangement of a D               (H) gene segment to a J               (H) gene segment to generate DJ(H) junctions, followed by rearrangement of a V               (H) gene segment to the DJ(H) junction to generate fully recombined VDJ alleles. In this review we discuss the regulatory features of each step of IgH gene assembly and the role of epigenetic mechanisms in achieving regulatory precision.
authors.affiliation: National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Subrahmanyam
authors.forename: Ranjan
authors.initials: R
authors.lastname: Sen
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism; D057890:Epigenomics; D018507:Gene Expression Regulation, Developmental; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D011995:Recombination, Genetic
chemical_list: D007143:Immunoglobulin Heavy Chains