title: Efficient enantioselective synthesis of 3-aminochroman derivatives through ruthenium-Synphos catalyzed asymmetric hydrogenation.
abstract: A highly enantioselective asymmetric hydrogenation of various trisubstituted enamides derived from chroman-3-ones promoted by cationic Ru-Synphos catalysts is reported. This atom-economical and clean method provides an efficient route to optically active 3-aminochroman derivatives, which are important pharmacophores found in numerous drug candidates, in high chemical yields and enantiomeric excesses up to 96%.
authors.affiliation: Chimie ParisTech, Laboratoire Charles Friedel (LCF), 75005 Paris, France,.
authors.forename: Zi
authors.initials: Z
authors.lastname: Wu
authors.forename: Tahar
authors.initials: T
authors.lastname: Ayad
authors.forename: Virginie
authors.initials: V
authors.lastname: Ratovelomanana-Vidal
mesh_terms: D002384:Catalysis; D002839:Chromans / Q000138:chemical synthesis*; D006865:Hydrogenation; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C568562:3-aminochroman; D002839:Chromans; D012428:Ruthenium