title: A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba.
abstract: We have evaluated the efficacy and safety of boron neutron capture therapy (BNCT) for recurrent glioma and malignant brain tumor using a new protocol. One of the two patients enrolled in this trial is a man with recurrent glioblastoma and the other is a woman with anaplastic meningioma. Both are still alive and no severe adverse events have been observed. Our findings suggest that NCT will be safe as a palliative therapy for malignant brain tumors.
authors.affiliation: Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tennodai, Tsukuba, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Aiyama
authors.forename: K
authors.initials: K
authors.lastname: Nakai
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Nariai
authors.forename: H
authors.initials: H
authors.lastname: Kumada
authors.forename: E
authors.initials: E
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Isobe
authors.forename: K
authors.initials: K
authors.lastname: Endo
authors.forename: T
authors.initials: T
authors.lastname: Takada
authors.forename: F
authors.initials: F
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Shibata
authors.forename: A
authors.initials: A
authors.lastname: Matsumura
mesh_terms: D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002985:Clinical Protocols; D003287:Contrast Media; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D049268:Positron-Emission Tomography; D012008:Recurrence
chemical_list: D003287:Contrast Media