title: Associations of EPHB1 polymorphisms with hepatocellular carcinoma in the Korean population.
abstract: Hepatocellular carcinoma (HCC) is a type of hypervascular tumor, and angiogenesis is important for HCC tumor growth. Eph receptor B1 (EPHB1), a member of the Eph family, mediates embryonic vascular system development and adult angiogenesis. This receptor may be involved in carcinogenesis of the digestive tract. Our aim was to examine the relationships between EPHB1 polymorphisms and HCC in the Korean population. Genomic DNA was extracted from 182 patients with HCC and 266 healthy subjects. EPHB1 polymorphisms were determined by polymerase chain reaction and direct sequencing. Multiple logistic regression models (log-additive, dominant, and recessive models) were used for odds ratios, 95% confidence intervals, and p values. Five polymorphisms (rs11929692, rs7644369, rs6776570, rs3821502, and rs6766459) of the EPHB1 gene and alleles of 2 polymorphisms (rs1502174 and rs9877457) were associated with HCC (p < 0.05 for both). Our results suggest that EPHB1 polymorphisms may be associated with susceptibility to HCC in the Korean population.
authors.affiliation: Department of Pharmacology, Kyung Hee University School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Jeon
authors.forename: Jae Jun
authors.initials: JJ
authors.lastname: Park
authors.forename: Jae Myung
authors.initials: JM
authors.lastname: Cha
authors.forename: Kwang Ro
authors.initials: KR
authors.lastname: Joo
authors.forename: Joung Il
authors.initials: JI
authors.lastname: Lee
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Shin
authors.forename: Hyun Phil
authors.initials: HP
authors.lastname: Shin
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008099:Liver / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D036225:Receptor, EphB1 / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D036225:Receptor, EphB1