title: The seroprevalence and seroincidence of enterovirus71 infection in infants and children in Ho Chi Minh City, Viet Nam.
abstract: Enterovirus 71 (EV71)-associated hand, foot and mouth disease has emerged as a serious public health problem in South East Asia over the last decade. To better understand the prevalence of EV71 infection, we determined EV71 seroprevalence and seroincidence amongst healthy infants and children in Ho Chi Minh City, Viet Nam. In a cohort of 200 newborns, 55% of cord blood samples contained EV71 neutralizing antibodies and these decayed to undetectable levels by 6 months of age in 98% of infants. The EV71 neutralizing antibody seroconversion rate was 5.6% in the first year and 14% in the second year of life. In children 5-15 yrs of age, seroprevalence of EV71 neutralizing antibodies was 84% and in cord blood it was 55%. Taken together, these data suggest EV71 force of infection is high and highlights the need for more research into its epidemiology and pathogenesis in high disease burden countries.
authors.affiliation: Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
authors.forename: Chau Bich Nguyen
authors.initials: CB
authors.lastname: Tran
authors.forename: Hieu Trong
authors.initials: HT
authors.lastname: Nguyen
authors.forename: Ha Thanh Thi
authors.initials: HT
authors.lastname: Phan
authors.forename: Ngoc Van
authors.initials: NV
authors.lastname: Tran
authors.forename: Bridget
authors.initials: B
authors.lastname: Wills
authors.forename: Jeremy
authors.initials: J
authors.lastname: Farrar
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Santangelo
authors.forename: Cameron P
authors.initials: CP
authors.lastname: Simmons
mesh_terms: D000293:Adolescent; D000328:Adult; D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D002648:Child; D003430:Cross-Sectional Studies; D029821:Enterovirus A, Human / Q000276:immunology / Q000502:physiology*; D004769:Enterovirus Infections / Q000097:blood / Q000453:epidemiology* / Q000821:virology*; D005312:Fetal Blood / Q000276:immunology / Q000821:virology; D006232:Hand, Foot and Mouth Disease / Q000188:drug therapy / Q000821:virology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D015994:Incidence; D007223:Infant; D016036:Seroepidemiologic Studies; D014744:Vietnam / Q000453:epidemiology; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D016756:Immunoglobulins, Intravenous