title: Olive oil reduces oxidative damage in a 3-nitropropionic acid-induced Huntington's disease-like rat model.
abstract: Free radicals contribute to altered neuronal functions in neurodegenerative diseases and brain aging, by producing lipid- and other molecule-dependent modifications. The Mediterranean diet has been associated with a reduced risk of neurodegenerative disease. This study sought to verify whether extra-virgin olive oil (EVOO) exerted a brain antioxidant effect, protecting the brain against the oxidative stress caused by 3-nitropropionic acid (3NP). 3NP was administered intraperitoneally (i.p.) at a dose of 20 mg/kg body weight over four consecutive days. EVOO (representing 10% of calorie intake in the total standard daily diet of rats) and hydroxytyrosol (HT; 2.5 mg/kg body weight) were administered for 14 days. In all studied samples, 3NP caused a rise in lipid peroxides (LPO) and a reduction in glutathione (GSH) content. While the results showed that EVOO and HT reduces lipid peroxidation product levels and blocks the GSH depletion prompted by 3NP in both striatum and rest of the brain in Wistar rats. In addition, EVOO blocks and reverses the effect of 3NP on succinate dehydrogenase activity. In brief, the data obtained indicate that EVOO and HT act as a powerful brain antioxidant.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Maimónides de Investigaciones Biomédicas de Córdoba (IMIBIC)/Universidad de Córdoba, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Tasset
authors.forename: A J
authors.initials: AJ
authors.lastname: Pontes
authors.forename: A J
authors.initials: AJ
authors.lastname: Hinojosa
authors.forename: R
authors.initials: R
authors.lastname: de la Torre
authors.forename: I
authors.initials: I
authors.lastname: Túnez
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D003342:Corpus Striatum / Q000187:drug effects; D004195:Disease Models, Animal; D005978:Glutathione / Q000032:analysis / Q000378:metabolism; D006816:Huntington Disease / Q000139:chemically induced / Q000188:drug therapy*; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009574:Nitro Compounds / Q000633:toxicity*; D000069463:Olive Oil; D018384:Oxidative Stress; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives; D010938:Plant Oils / Q000008:administration & dosage*; D011422:Propionates / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D009574:Nitro Compounds; D000069463:Olive Oil; D010938:Plant Oils; D011422:Propionates; C005975:3,4-dihydroxyphenylethanol; D013385:Succinate Dehydrogenase; D005978:Glutathione; D010626:Phenylethyl Alcohol; C015392:3-nitropropionic acid