title: Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats.
abstract: OBJECTIVE
  To evaluate the hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatic damage in rats.
  
  
  METHODS
  The plant material was shade dried, powdered and extracted with ethanol. Liv 52 and silymarin were used as standard drugs and 2% gum acacia as a control (vehicle). Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and lipid peroxides were tested, and phytochemical tests were also performed.
  
  
  RESULTS
  Paracetamol (2 g/kg) increased the serum levels of alanine aminotransfer (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and the lipid peroxides. Treatment of Liv 52, silymarin and ethanolic extract of Terminalia paniculata (200 mg/kg) altered levels of biochemical marker and showed significant hepatoprotective activity. Ethanolic extract revealed the presence of phenolic compound and flavanoids. Our findings suggested that ethanolic bark extract of Terminalia paniculata possessed hepatoprotective activity in a dose dependent manner.
  
  
  CONCLUSIONS
  Terminalia paniculata possesses hepatoprotective activity. It could be an effective and promising preventive agent against PCT induced hepatotoxicity.
authors.affiliation: Department of Pharmacology, Kasturba Medical College, Manipal University, Karnataka, India.
authors.forename: B R
authors.initials: BR
authors.lastname: Eesha
authors.forename: V
authors.initials: V
authors.lastname: Mohanbabu Amberkar
authors.forename: K
authors.initials: K
authors.lastname: Meena Kumari
authors.forename: Babu
authors.initials: B
authors.lastname: Sarath
authors.forename: M
authors.initials: M
authors.lastname: Vijay
authors.forename: M
authors.initials: M
authors.lastname: Lalit
authors.forename: R
authors.initials: R
authors.lastname: Rajput
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D029766:Terminalia
chemical_list: D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D000082:Acetaminophen