title: Dissecting aneurysm of the middle cerebral artery treated with heparin infusion in a 6-year-old child; neurological recovery with delayed spontaneous thrombosis: case illustration and literature review.
abstract: Aneurysms in the pediatric population are a rare pathology with specific features which requires a deep knowledge of their pathogenesis for the best therapeutic choice; the authors report their experience with a patient presenting aneurysm of the middle cerebral artery (MCA) associated with proximal stenosis of the vessel. A six-year-old girl came to our observation after sudden onset of headache and left hemiparesis. Angio-MRI and angio-CT scan showed a right MCA dissecting aneurysms associated with proximal stenosis of the vessel. Patient started a therapy with low molecular weight heparin (LMWH), replaced, 15 days later, with acetyl-salicylic acid (ASA). Patient showed a rapid and almost complete neurological recovery, despite several radiological exams confirmed a complete occlusion of the right MCA. As many other authors noted, dissecting aneurysms in the pediatric population are probably due to a defect of the entire arterial wall. Combination of stenosis, turbulence and partial thrombosis of the aneurysm led to a complete occlusion of artery involved, leading to the formation of collateral circles. In our case, complete thrombosis was probably delayed with anticoagulant therapy and the progressive reinforcement of collateral circles lead to the patient's neurological recovery.
authors.affiliation: Department of Neurological Sciences, Neurosurgery, University of Rome "Sapienza", Viale Giacinta Pezzana 92, 00197 Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Anichini
authors.forename: E
authors.initials: E
authors.lastname: Passacantilli
authors.forename: J
authors.initials: J
authors.lastname: Lenzi
authors.forename: G
authors.initials: G
authors.lastname: Guidetti
authors.forename: A
authors.initials: A
authors.lastname: Santoro
mesh_terms: D000784:Aortic Dissection / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D002648:Child; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D009422:Nervous System Diseases / Q000188:drug therapy / Q000209:etiology*; D020127:Recovery of Function / Q000187:drug effects*; D014057:Tomography, X-Ray Computed
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin