title: Successful treatment of severe sepsis with recombinant activated protein C during the third trimester of pregnancy.
abstract: BACKGROUND
  Severe sepsis in pregnancy is associated with multiorgan failure and a high risk of death for the mother and fetus.
  
  
  METHODS
  We present the case of a pregnant patient at 26 weeks of gestation with severe sepsis secondary to pneumonia. She was admitted to the intensive care unit and started on combination antibiotics and bilevel positive airway pressure. Her condition continued to deteriorate, and she was treated with recombinant activated protein C (drotrecogin alfa). She improved and delivered at 28 weeks of gestation after preterm labor; neither the patient nor the neonate had evidence of drug-related complications.
  
  
  CONCLUSIONS
  This report describes a case of severe sepsis at 26 weeks of gestation secondary to pneumonia, with successful maternal and fetal outcome after use of drotrecogin alfa (activated).
authors.affiliation: From the Section on Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston Salem, North Carolina.
authors.forename: Ridhima
authors.initials: R
authors.lastname: Gupta
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Strickland
authors.forename: Heather L
authors.initials: HL
authors.lastname: Mertz
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011014:Pneumonia / Q000150:complications*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000209:etiology*; D011263:Pregnancy Trimester, Third; D011486:Protein C / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D011486:Protein C; D011994:Recombinant Proteins; C421124:drotrecogin alfa activated