title: Inhibitory effects of 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, β-diketone structural analogues of curcumin, on chemical-induced tumor promotion and inflammation in mouse skin.
abstract: Dibenzoylmethane (DBM), a β-diketone structural analogue of curcumin, has been reported to exhibit anti-tumorigenic and chemopreventive activities. Due to the structural resemblance of DBM to the anti-inflammatory curcumin and an aspirin-like skeleton of DBM derivatives, we tested the anti-inflammatory effects of DBM and its derivatives, 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion as well as TPA- and arachidonic acid-induced mouse ear edema in skin of CD-1 mice. Topical application of 10 μmol DBM together with TPA on the back of mice previously treated with 7,12-dimethylbenz[α]anthracene (DMBA) inhibited TPA-induced skin tumor promotion significantly. In addition, 1,3-bis-(2-acetoxy phenyl)-propane-1,3-dione was a superior anti-inflammatory agent to aspirin (80% of inhibition), on TPA-induced mouse ear edema and reduced the production of prostaglandin E2 (PGE(2)), comparable to aspirin. Taken together, 1,3-bis-(2-acetoxyphenyl-propane-1,3-dione merits a valuable anti-inflammatory agent substituting aspirin in therapeutic treatment as well prevention of cancer.
authors.affiliation: Department of Food Science, China University of Science and Technology, 245 Yen-Chiu-Yuan Rd., Sec. 3, Nankang, Taipei 115, Taiwan. cclin@cc.cust.edu.tw
authors.forename: Chuan-Chuan
authors.initials: CC
authors.lastname: Lin
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.forename: Chi-Tang
authors.initials: CT
authors.lastname: Ho
authors.forename: Mou-Tuan
authors.initials: MT
authors.lastname: Huang
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000494:pharmacology; D001241:Aspirin / Q000737:chemistry / Q000494:pharmacology; D002273:Carcinogens / Q000737:chemistry / Q000494:pharmacology; D003474:Curcumin / Q000031:analogs & derivatives*; D003872:Dermatitis / Q000188:drug therapy*; D004431:Ear, External / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D002273:Carcinogens; D007659:Ketones; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D015127:9,10-Dimethyl-1,2-benzanthracene; D003474:Curcumin; D013755:Tetradecanoylphorbol Acetate; D001241:Aspirin