title: Influence of hemodynamic factors on rupture of intracranial aneurysms: patient-specific 3D mirror aneurysms model computational fluid dynamics simulation.
abstract: OBJECTIVE
  Hemodynamics factors play an important role in the rupture of cerebral aneurysms. The purpose of this study was to evaluate the impact of hemodynamic factors on the rupture of the MANs with 3D reconstruction model CFD simulation.
  
  
  METHODS
  RDSA was performed in 9 pairs of intracranial MANs. Each pair was divided into ruptured and unruptured groups. The hemodynamic factors of the aneurysms and their parent arteries were compared.
  
  
  RESULTS
  There was a significant difference in the WSS at peak systole between the regions of the aneurysms and their parent arteries in the ruptured group (ie, 6.49 ± 3.48 Pa versus 8.78 ± 3.57 Pa, P =.015) but not in the unruptured group (ie, 9.80 ± 4.12 Pa versus 10.17 ± 7.48 Pa, P =.678). The proportion of the low WSS area to the whole area of the aneurysms was 12.20 ± 18.08% in the ruptured group and 3.96 ± 6.91% in the unruptured group; the difference between the 2 groups was statistically significant (P =.015). The OSI was 0.0879 ± 0.0764 in the ruptured group, which was significantly higher than that of the unruptured group (ie, 0.0183 ± 0.0191, P =.008).
  
  
  CONCLUSIONS
  MANs may be a useful disease model to investigate possible causes linked to ruptured aneurysms. The ruptured aneurysms manifested lower WSS compared with their parent arteries, a higher proportion of the low WSS area to the whole area of aneurysm, and higher OSI compared with the unruptured aneurysms.
authors.affiliation: Shanghai Department of Radiology, Fudan University, Huashan Hospital, Shanghai, China.
authors.forename: G
authors.initials: G
authors.lastname: Lu
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.forename: X L
authors.initials: XL
authors.lastname: Zhang
authors.forename: S Z
authors.initials: SZ
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Hong
authors.forename: Z
authors.initials: Z
authors.lastname: Hu
authors.forename: D Y
authors.initials: DY
authors.lastname: Geng
mesh_terms: D000328:Adult; D000368:Aged; D017542:Aneurysm, Ruptured / Q000453:epidemiology / Q000503:physiopathology*; D001809:Blood Viscosity / Q000502:physiology; D002536:Cerebral Arteries / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D057446:Hydrodynamics; D002532:Intracranial Aneurysm / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D012307:Risk Factors