title: Large cell neuroendocrine carcinoma of the endometrium: an extremely uncommon diagnosis, but worth the efforts.
abstract: Neuroendocrine carcinomas (NEC) of the female genital tract are aggressive and uncommon tumors. They usually involve the cervix and ovary, and are seen very rarely in the endometrium. The overwhelming majority of endometrial NECs are of conventional small cell type (up to 60 cases). Only seven cases of large cell type NEC of the endometrium have been reported. We report a case of large-cell neuroendocrine carcinoma (LCNEC) of the endometrium in a 70-year-old female. The case is described for its rarity and shows that a high index of suspicion can help the pathologist to use immunohistochemistry and in turn help in selection of appropriate chemotherapy.
authors.affiliation: Department of Pathology, Tata Memorial Hospital, Parel, Mumbai 400 012, Maharashtra, India. kedardeodhar@hotmail.com
authors.forename: Kedar K
authors.initials: KK
authors.lastname: Deodhar
authors.forename: R A
authors.initials: RA
authors.lastname: Kerkar
authors.forename: Pallavi
authors.initials: P
authors.lastname: Suryawanshi
authors.forename: Hari
authors.initials: H
authors.lastname: Menon
authors.forename: Santosh
authors.initials: S
authors.lastname: Menon
mesh_terms: D000368:Aged; D018287:Carcinoma, Large Cell / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D016896:Treatment Outcome