title: Repeatability of measured brain volume by atlas-based method using T1-weighted image.
abstract: The aims of this study were to (1) investigate the repeatability of measured volumes using the atlas-based method in each area of the brain, and (2) validate our hypothesis that the repeatability of the measured volumes with the atlas-based method was improved by using smoothed images. T1-weighted magnetic resonance images were obtained in five healthy subjects using the 1.5-T scanner. We used Statistical Parametric Mapping 5 and WFU PickAtlas software (theory of the Talairach brain atlas). Volumes inside region-of-interest (ROI) were measured in ten sets (five subjects × right and left) on six ROIs, respectively. One set comprises five images (one subject × five 3D-T1WIs). The percentage change was defined as [100 × (measured volume-mean volume in each set)/mean volume in each set)]. As a result, the average percentage changes using non-smoothed image on each ROI were as follows: gray matter, 0.482%; white matter, 0.375%; cerebrospinal fluid images, 0.731%; hippocampus, 0.864%; orbital gyrus, 1.692%; cerebellum posterior lobe, 0.854%. Using smoothed images with large FWHM resulted in improved repeatability on orbital gyrus. This is the first report of repeatability in each brain structure and improved repeatability with smoothed images using the atlas-based method.
authors.affiliation: Department of Radiological Technology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. car6_pa2_rw@yahoo.co.jp
authors.forename: Masami
authors.initials: M
authors.lastname: Goto
authors.forename: Tosiaki
authors.initials: T
authors.lastname: Miyati
authors.forename: Osamu
authors.initials: O
authors.lastname: Abe
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Takao
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kurosu
authors.forename: Naoto
authors.initials: N
authors.lastname: Hayashi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.forename: Harushi
authors.initials: H
authors.lastname: Mori
authors.forename: Akira
authors.initials: A
authors.lastname: Kunimatsu
authors.forename: Kenji
authors.initials: K
authors.lastname: Ino
authors.forename: Keiichi
authors.initials: K
authors.lastname: Yano
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping / Q000379:methods*; D002531:Cerebellum / Q000033:anatomy & histology; D005625:Frontal Lobe / Q000033:anatomy & histology; D006624:Hippocampus / Q000033:anatomy & histology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009929:Organ Size; D012016:Reference Values; D015203:Reproducibility of Results; D012494:Sampling Studies; D055815:Young Adult