title: Effectiveness of cyclosporine and mycophenolate mofetil in a child with refractory evans syndrome.
abstract: Evans Syndrome is a rare autoimmune disease consisting of hemolytic anemia, thrombocytopenia and/or neutropenia. It may be associated with other autoimmune or lymphoproliferative diseases. Its course can be extremely serious and, rarely, even life-threatening; thus it represents a excellent treatment challenge for the pediatric hematologist. First line treatment consists of steroids and/or immunoglobulin; further therapy with rituximab, vincristine, cyclophosphamide and other immunosuppressive drugs can be considered in unresponsive patients. We describe a baby with refractory Evans Syndrome that was cured by prolonged administration of mycophenolate mofetil and remained disease-free for 4 years after the discontinuation of treatment.
authors.affiliation: Pediatric Hematology and Oncology Unit, G. Di Cristina Children's Hospital, Palermo;
authors.forename: Piero
authors.initials: P
authors.lastname: Farruggia
authors.forename: Alessandra
authors.initials: A
authors.lastname: Macaluso
authors.forename: Serena
authors.initials: S
authors.lastname: Tropia
authors.forename: Selene
authors.initials: S
authors.lastname: Genova
authors.forename: Olivia
authors.initials: O
authors.lastname: Paolicchi
authors.forename: Floriana
authors.initials: F
authors.lastname: Di Marco
authors.forename: Paolo
authors.initials: P
authors.lastname: D'Angelo