title: In vivo animal histology and clinical evaluation of multisource fractional radiofrequency skin resurfacing (FSR) applicator.
abstract: OBJECTIVE
  Acne scars are one of the most difficult disorders to treat in dermatology. The optimal treatment system will provide minimal downtime resurfacing for the epidermis and non-ablative deep volumetric heating for collagen remodeling in the dermis. A novel therapy system (EndyMed Ltd., Cesarea, Israel) uses phase-controlled multi-source radiofrequency (RF) to provide simultaneous one pulse microfractional resurfacing with simultaneous volumetric skin tightening.
  
  
  METHODS
  The study included 26 subjects (Fitzpatrick's skin type 2-5) with moderate to severe wrinkles and 4 subjects with depressed acne scars. Treatment was repeated each month up to a total of three treatment sessions. Patients' photographs were graded according to accepted scales by two uninvolved blinded evaluators.
  
  
  RESULTS
  Significant reduction in the depth of wrinkles and acne scars was noted 4 weeks after therapy with further improvement at the 3-month follow-up.
  
  
  CONCLUSIONS
  Our data show the histological impact and clinical beneficial effects of simultaneous RF fractional microablation and volumetric deep dermal heating for the treatment of wrinkles and acne scars.
authors.affiliation: Weill Medical College, Cornell University, New York, USA. nssderm@sadickdermatology.com
authors.forename: Neil S
authors.initials: NS
authors.lastname: Sadick
authors.forename: Masaki
authors.initials: M
authors.lastname: Sato
authors.forename: Diana
authors.initials: D
authors.lastname: Palmisano
authors.forename: Ido
authors.initials: I
authors.lastname: Frank
authors.forename: Hila
authors.initials: H
authors.lastname: Cohen
authors.forename: Yoram
authors.initials: Y
authors.lastname: Harth
mesh_terms: D000152:Acne Vulgaris / Q000150:complications* / Q000473:pathology; D000328:Adult; D000368:Aged; D000818:Animals; D002921:Cicatrix / Q000209:etiology / Q000532:radiotherapy*; D003357:Cosmetic Techniques / Q000295:instrumentation*; D019583:Dose Fractionation, Radiation; D005145:Face; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000078702:Radiofrequency Therapy; D012867:Skin / Q000473:pathology / Q000528:radiation effects; D015595:Skin Aging / Q000528:radiation effects*; D013552:Swine; D055815:Young Adult