title: Highly active copper-network catalyst for the direct aldol reaction.
abstract: The development of a highly active solid-phase catechol-copper network catalyst for direct aldol reaction is described. The catalyst was prepared from an alkyl-chain-linked bis(catechol) and a copper(II) complex. The direct aldol reaction between carbonyl compounds (aldehydes and ketones) and methyl isocyanoacetate was carried out using 0.1-1 mol% [Cu] catalyst to give the corresponding oxazolines at yields of up to 99% and a trans/cis ratio of >99:1. The catalyst was reused with no loss of catalytic activity. A plausible reaction pathway is also described.
authors.affiliation: RIKEN Advanced Science Institute, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ohta
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Uozumi
authors.forename: Yoichi M A
authors.initials: YM
authors.lastname: Yamada