title: High expression of TGF-β1 in the vaginal incisional margin predicts poor prognosis in patients with stage Ib-IIa cervical squamous cell carcinoma.
abstract: This study evaluated the relationship between altered cytoplasmic expression of TGF-β1 in tissues of the vaginal incisional margin and vaginal cancer recurrence in patients with stage Ib-IIa cervical squamous cell carcinoma (CSCC). This paper also discusses the prognostic value of TGF-β1 expression at these locations. We found that TGF-β1 expression in the vaginal margin had a close association with vaginal recurrence of stage Ib-IIa CSCC and was an independent prognostic marker of this disease.
authors.affiliation: The Department of Gynecology, The First Affiliated Hospital of Henan University of Science and Technology, Jinghua Road, Luoyang, 471003, Henan, China. fandmhnst@sina.cn
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Fan
authors.forename: Xin-Jun
authors.initials: XJ
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Dan
authors.initials: D
authors.lastname: Zhou
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Kong
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Mei-Mei
authors.initials: MM
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery*; D002584:Cervix Uteri / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*; D014621:Vagina / Q000473:pathology* / Q000601:surgery*
chemical_list: D053773:Transforming Growth Factor beta1