title: Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis.
abstract: In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell-cycle machinery is largely unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine-tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2;3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development.
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent, Belgium.
authors.forename: Steffen
authors.initials: S
authors.lastname: Vanneste
authors.forename: Frederik
authors.initials: F
authors.lastname: Coppens
authors.forename: Eunkyoung
authors.initials: E
authors.lastname: Lee
authors.forename: Tyler J
authors.initials: TJ
authors.lastname: Donner
authors.forename: Zidian
authors.initials: Z
authors.lastname: Xie
authors.forename: Gert
authors.initials: G
authors.lastname: Van Isterdael
authors.forename: Stijn
authors.initials: S
authors.lastname: Dhondt
authors.forename: Freya
authors.initials: F
authors.lastname: De Winter
authors.forename: Bert
authors.initials: B
authors.lastname: De Rybel
authors.forename: Marnik
authors.initials: M
authors.lastname: Vuylsteke
authors.forename: Lieven
authors.initials: L
authors.lastname: De Veylder
authors.forename: Jiří
authors.initials: J
authors.lastname: Friml
authors.forename: Dirk
authors.initials: D
authors.lastname: Inzé
authors.forename: Erich
authors.initials: E
authors.lastname: Grotewold
authors.forename: Enrico
authors.initials: E
authors.lastname: Scarpella
authors.forename: Fred
authors.initials: F
authors.lastname: Sack
authors.forename: Gerrit T S
authors.initials: GT
authors.lastname: Beemster
authors.forename: Tom
authors.initials: T
authors.lastname: Beeckman
mesh_terms: D017360:Arabidopsis / Q000166:cytology* / Q000235:genetics; D029681:Arabidopsis Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D002453:Cell Cycle; D002455:Cell Division; D056751:Cyclin A2 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D015536:Down-Regulation; D018507:Gene Expression Regulation, Developmental; D018506:Gene Expression Regulation, Plant; D009024:Morphogenesis; D009928:Organ Specificity; D018515:Plant Leaves / Q000378:metabolism; D018517:Plant Roots / Q000378:metabolism; D011123:Polyploidy; D014157:Transcription Factors / Q000502:physiology
chemical_list: D029681:Arabidopsis Proteins; D056751:Cyclin A2; C507998:FLP protein, Arabidopsis; C507999:Myb88 protein, Arabidopsis; D014157:Transcription Factors; C543427:cyclin A2;3 protein, Arabidopsis