title: Role of (68)Ga-DOTATOC PET-CT in the diagnosis and staging of pancreatic neuroendocrine tumours.
abstract: OBJECTIVE
  The objective of the present study was to evaluate the role of (68)Ga-DOTA(0)-Phe(1)-Tyr(3)-octreotide ((68)Ga-DOTATOC) positron emission tomography computed tomography (PET-CT) for detection and staging of pancreatic neuroendocrine tumours (NETs).
  
  
  METHODS
  Twenty patients with clinically suspected and/or histopathologically proven pancreatic NET underwent (68)Ga-DOTATOC PET-CT imaging for staging and /or localisation of primary lesion. They also underwent contrast enhanced CT (CECT) and 8 patients underwent (18)F-FDG PET-CT. SUVmax of primary and metastatic lesions were measured. Results were verified with histopathology for primary tumour and with clinical follow up/MRI and /or biopsy for metastatic disease. Results of (68)Ga-DOTATOC PET-CT were compared to CECT and (18)F-FDG PET-CT.
  
  
  RESULTS
  (68)Ga-DOTATOC PET-CT correctly localised primary in all 20, CECT in 15 and (18)F-FDG PET-CT in 2 patients. (68)Ga-DOTATOC PET-CT demonstrated metastases in 13 patients, CECT in 7 and (18)F-FDG PET-CT in 2. (68)Ga-DOTATOC PET-CT emerged as the best investigation with 100% sensitivity and PPV for detecting primary tumour and metastatic disease. The detection rate of CECT was lower than (68)Ga-DOTATOC PET-CT, both for primary tumour (20vs.15) or metastatic disease (13vs.7). (18)F-FDG PET-CT performed poorly for primary and metastasis.
  
  
  CONCLUSIONS
  Ga-DOTATOC PET-CT is a very useful imaging investigation for diagnosing and staging pancreatic NET.
authors.affiliation: Department of Nuclear Medicine, All India Institute of Medical Sciences, E-81, Ansari Nagar (east), AIIMS Campus, New Delhi 110029, India. rkphulia@yahoo.com
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Punit
authors.initials: P
authors.lastname: Sharma
authors.forename: Pramod
authors.initials: P
authors.lastname: Garg
authors.forename: Sellam
authors.initials: S
authors.lastname: Karunanithi
authors.forename: Niraj
authors.initials: N
authors.lastname: Naswa
authors.forename: Raju
authors.initials: R
authors.lastname: Sharma
authors.forename: Sanjay
authors.initials: S
authors.lastname: Thulkar
authors.forename: Sneh
authors.initials: S
authors.lastname: Lata
authors.forename: Arun
authors.initials: A
authors.lastname: Malhotra
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000494:pharmacology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging / Q000379:methods; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000473:pathology; D015282:Octreotide / Q000031:analogs & derivatives* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000494:pharmacology*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C499142:Ga(III)-DOTATOC; D009942:Organometallic Compounds; D015282:Octreotide