title: Venlafaxine-induced acute eosinophilic pneumonia.
abstract: BACKGROUND
  Acute Eosinophilic Pneumonia (AEP) is a severe syndrome which can be potentially induced by many reasons, including drugs. It is characterized by pulmonary infiltrates, peripheral blood eosinophilia and respiratory failure. AEP has rarely been associated with antidepressant treatment.
  
  
  METHODS
  We report a case of an 80-year-old woman who presented with fever, lung infiltrates, peripheral blood eosinophilia and acute respiratory failure. All evidence charge venlafaxine as the only possible causal factor. The syndrome rapidly resolved after discontinuation of the drug and upon reception of corticosteroids in low doses. The patient had a past medical history of AEP induced by sertraline and a recent medical history of Acute Lung Injury on the context of acute pancreatitis during treatment with venlafaxine.
  
  
  CONCLUSIONS
  Pathophysiological mechanisms implicated in the development of AEP in our patient seems to be associated with eotaxin and serotonin eosinophilic-specific chemoattracting action.
  
  
  CONCLUSIONS
  This is a case report with clinical adverse reaction of AEP in two antidepressant agents (venlafaxine and sertraline) with a similar neurochemical mechanism of action via the serotoninergic system.
authors.affiliation: National and Kapodistrian University of Athens, Medical School, 2nd Department of Psychiatry, University ATTIKON General Hospital, 12462 Athens, Greece.
authors.forename: Evi
authors.initials: E
authors.lastname: Tsigkaropoulou
authors.forename: Despina
authors.initials: D
authors.lastname: Hatzilia
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Rizos
authors.forename: Christos
authors.initials: C
authors.lastname: Christodoulou
authors.forename: Stylianos
authors.initials: S
authors.lastname: Loukides
authors.forename: Spyridon
authors.initials: S
authors.lastname: Papiris
authors.forename: Lefteris
authors.initials: L
authors.lastname: Lykouras
mesh_terms: D055371:Acute Lung Injury; D000369:Aged, 80 and over; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D003511:Cyclohexanols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006115:Greece; D006801:Humans; D017063:Outcome Assessment, Health Care; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000503:physiopathology; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D000069470:Venlafaxine Hydrochloride