title: Squamous cell carcinoma arising from chronic osteomyelitis.
abstract: OBJECTIVE
  Our aim was to present the results from a retrospective study of 7 cases of squamous cell carcinoma arising from chronic osteomyelitis.
  
  
  METHODS
  We treated seven cases of chronic osteomyelitis related squamous cell carcinoma between 1993 and 2005. The patients had an average age of 54.5 (range: 38-71) years, with a male predominance (6 men, 1 woman). We analyzed the time up to cancerization, the localization and histopathological type of the carcinoma, and the type and result of the treatment.
  
  
  RESULTS
  The mean time between the occurrence of the skin lesions and the diagnosis of malignant degeneration was 24.5 (range: 9 to 40) years. The carcinoma resulted from tibia osteomyelitis in 4 cases, femur osteomyelitis in 2 cases and humerus osteomyelitis in one. The pathological examination showed five cases of a well differentiated squamous cell carcinoma with bone invasion, and two cases of invasive squamous cell carcinoma. The treatment consisted of amputation in all but one patient, who refused the amputation. The six amputee patients did not show local recurrence or metastatic dissemination over a period of five years.
  
  
  CONCLUSIONS
  Amputation appears to be an effective treatment method in squamous carcinoma secondary to chronic osteomyelitis.
authors.affiliation: Department of Orthopedic Surgery, CHU Ibn Sina Hospital, Rabat, Morocco. mmedalami@gmail.com
authors.forename: Mohammed
authors.initials: M
authors.lastname: Alami
authors.forename: Mustapha
authors.initials: M
authors.lastname: Mahfoud
authors.forename: Ahmed
authors.initials: A
authors.lastname: El Bardouni
authors.forename: Mohamed Saleh
authors.initials: MS
authors.lastname: Berrada
authors.forename: Moradh
authors.initials: M
authors.lastname: El Yaacoubi
mesh_terms: D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D002908:Chronic Disease; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011859:Radiography; D012189:Retrospective Studies; D012737:Sex Factors; D013995:Time; D016896:Treatment Outcome