title: CK2α is essential for embryonic morphogenesis.
abstract: CK2 is a highly conserved serine-threonine kinase involved in biological processes such as embryonic development, circadian rhythms, inflammation, and cancer. Biochemical experiments have implicated CK2 in the control of several cellular processes and in the regulation of signal transduction pathways. Our laboratory is interested in characterizing the cellular, signaling, and molecular mechanisms regulated by CK2 during early embryonic development. For this purpose, animal models, including mice deficient in CK2 genes, are indispensable tools. Using CK2α gene-deficient mice, we have recently shown that CK2α is a critical regulator of mid-gestational morphogenetic processes, as CK2α deficiency results in defects in heart, brain, pharyngeal arch, tail bud, limb bud, and somite formation. Morphogenetic processes depend upon the precise coordination of essential cellular processes in which CK2 has been implicated, such as proliferation and survival. Here, we summarize the overall phenotype found in CK2α                         (-/-                         ) mice and describe our initial analysis aimed to identify the cellular processes affected in CK2α mutants.
authors.affiliation: Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. isdoming@bu.edu
authors.forename: Isabel
authors.initials: I
authors.lastname: Dominguez
authors.forename: Irene R
authors.initials: IR
authors.lastname: Degano
authors.forename: Kathleen
authors.initials: K
authors.lastname: Chea
authors.forename: Julie
authors.initials: J
authors.lastname: Cha
authors.forename: Paul
authors.initials: P
authors.lastname: Toselli
authors.forename: David C
authors.initials: DC
authors.lastname: Seldin
mesh_terms: D000818:Animals; D017209:Apoptosis; D047390:Casein Kinase II / Q000172:deficiency / Q000378:metabolism*; D049109:Cell Proliferation; D004622:Embryo, Mammalian / Q000033:anatomy & histology / Q000166:cytology / Q000201:enzymology; D047108:Embryonic Development; D006257:Head / Q000196:embryology; D018878:Limb Buds / Q000196:embryology; D051379:Mice; D009024:Morphogenesis; D010641:Phenotype; D019170:Somites / Q000166:cytology / Q000201:enzymology; D013623:Tail / Q000196:embryology
chemical_list: D047390:Casein Kinase II