title: Human T-lymphotropic virus 1 (HTLV-1) infection--dermatological implications.
abstract: Human T-lymphotropic virus type 1 (HTLV-1) is a type C retrovirus primarily endemic to Japan, Central and South America, the Middle East, regions of Africa, and the Caribbean. Currently, an estimated 10-20 million people worldwide are infected with this virus. Although the majority of infected individuals remain asymptomatic, HTLV-1 is the causative agent of a number of disorders, notably adult T-cell leukemia/lymphoma (ATLL) and a progressive demyelinating neurological disorder, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition to ATLL and HAM/TSP, HTLV-1 has been associated with a spectrum of skin disorders, such as infective dermatitis associated with HTLV-1, crusted scabies, and leprosy. The understanding of the interaction between virus and host response has improved markedly, but there are still few treatment options.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL 33136, USA.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Amano
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Setoyama
authors.forename: Annika
authors.initials: A
authors.lastname: Grant
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Kerdel
mesh_terms: D015490:HTLV-I Infections / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D015368:Human T-lymphotropic virus 1; D006801:Humans; D017193:Skin Diseases, Viral / Q000473:pathology / Q000503:physiopathology* / Q000821:virology