title: [Obesity and ischemic heart disease. Is there a link between wellness' diseases?].
abstract: Obesity, the most common nutritional disorder in Western countries, is usually associated to cardiovascular diseases. However, the precise molecular pathways underlying this close association remain poorly understood. Nowadays, the adipose tissue is considered as an endocrine organ able to produce substances called adipo(cyto)kines that have different effects on lipid metabolism, closely involved in metabolic syndrome, and cardiovascular risk. The increased cardiovascular risk can be related also to peculiar dysfunction in the endocrine activity of adipose tissue observed in obesity responsible of vascular impairment (including endothelial dysfunction), prothrombotic tendency, and low-grade chronic inflammation. The present review aims at providing an up-dated overview on the adipocyte-derived molecules potentially involved in cardiovascular pathophysiology.
authors.affiliation: Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli "Federico II", Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Maresca
authors.forename: Greta Luana
authors.initials: GL
authors.lastname: D'Ascoli
authors.forename: Francesca
authors.initials: F
authors.lastname: Ziviello
authors.forename: Gianluca
authors.initials: G
authors.lastname: Petrillo
authors.forename: Vito
authors.initials: V
authors.lastname: Di Palma
authors.forename: Angelo
authors.initials: A
authors.lastname: Russo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Grieco
authors.forename: Plinio
authors.initials: P
authors.lastname: Cirillo
mesh_terms: D054392:Adipokines / Q000502:physiology; D000273:Adipose Tissue / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications; D015850:Interleukin-6 / Q000097:blood; D017202:Myocardial Ischemia / Q000209:etiology*; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D054392:Adipokines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha