title: Priorities for mixtures health effects research.
abstract: In order to better inform scientific decision making in the occupational environment, we need a better understanding of the toxicology of mixed exposures. In particular, we need an understanding of the dose-response relationship from the level of individual or population exposure down to the molecular level (and then back up again from the molecular level to the specific health-related response of the organism as a whole). Mixtures toxicology is proving to be different from single-chemical toxicology in several fundamental but barely recognized ways: Knowledge gained in mixtures research should be able to improve current risk assessment and mitigation or intervention methods. In NIOSH's National Occupational Research Agenda (NORA) three priority areas have been identified:
authors.affiliation: Air Force Research Laboratory, Wright-Patterson Air Force Base, P.O. Box 31009, Dayton, OH 45437-0009, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Robinson
authors.forename: Margaret
authors.initials: M
authors.lastname: Macdonell