title: Adeno-associated virus antibody profiles in newborns, children, and adolescents.
abstract: Neutralizing antibodies (NAb) to an adeno-associated virus (AAV) vector due to previous natural infection with wild-type AAV can significantly limit gene transfer. NAb titers to AAV serotype 2 (AAV2) and AAV8 in human subjects (0 to 18 years) were studied. NAb prevalence is moderate at birth, decreases markedly from 7 to 11 months, and then progressively increases through childhood and adolescence.
authors.affiliation: Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Roberto
authors.initials: R
authors.lastname: Calcedo
authors.forename: Hiroki
authors.initials: H
authors.lastname: Morizono
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.forename: Robert
authors.initials: R
authors.lastname: McCarter
authors.forename: Jianping
authors.initials: J
authors.lastname: He
authors.forename: David
authors.initials: D
authors.lastname: Jones
authors.forename: Mark L
authors.initials: ML
authors.lastname: Batshaw
authors.forename: James M
authors.initials: JM
authors.lastname: Wilson
mesh_terms: D000293:Adolescent; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D000229:Dependovirus / Q000145:classification / Q000235:genetics / Q000276:immunology*; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D010322:Parvoviridae Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D015995:Prevalence; D012703:Serotyping; D014161:Transduction, Genetic
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral