title: A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles.
abstract: A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level.
authors.affiliation: Advanced Functional Materials Laboratory, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. wenruru@ecust.edu.cn
authors.forename: Wenru
authors.initials: W
authors.lastname: Zhao
authors.forename: Hongti
authors.initials: H
authors.lastname: Zhang
authors.forename: Qianjun
authors.initials: Q
authors.lastname: He
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Li
authors.forename: Jinlou
authors.initials: J
authors.lastname: Gu
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004798:Enzymes; D004800:Enzymes, Immobilized; D007328:Insulin; D012822:Silicon Dioxide; D005949:Glucose Oxidase; D005947:Glucose