title: Instrumental activities of daily living impairment is associated with increased amyloid burden.
abstract: OBJECTIVE
  Instrumental activities of daily living (IADL) impairment in Alzheimer's disease has been associated with global amyloid deposition in postmortem studies. We sought to determine whether IADL impairment is associated with increased cortical Pittsburgh Compound B (PiB) retention.
  
  
  METHODS
  Fifty-five subjects (19 normal older controls, NC, and 36 with mild cognitive impairment, MCI) underwent clinical assessments and dynamic PiB positron emission tomography imaging.
  
  
  RESULTS
  A linear multiple regression model showed that greater IADL impairment was associated with greater global PiB retention in all subjects (R(2) = 0.40; unstandardized partial regression coefficient, β = 5.8; p = 0.0002) and in MCI subjects only (R(2) = 0.28; β = 6.1; p = 0.003), but not in NC subjects only.
  
  
  CONCLUSIONS
  These results suggest that daily functional impairment is related to greater amyloid burden in MCI.
authors.affiliation: Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA. gamarshall@partners.org
authors.forename: Gad A
authors.initials: GA
authors.lastname: Marshall
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Olson
authors.forename: Meghan T
authors.initials: MT
authors.lastname: Frey
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Maye
authors.forename: J Alex
authors.initials: JA
authors.lastname: Becker
authors.forename: Dorene M
authors.initials: DM
authors.lastname: Rentz
authors.forename: Reisa A
authors.initials: RA
authors.lastname: Sperling
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000523:psychology*; D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D001822:Body Burden; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D013702:Temporal Lobe / Q000502:physiology; D013844:Thiazoles / Q000378:metabolism
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D013844:Thiazoles