title: Role of curcumin on chloroquine phosphate-induced reproductive toxicity.
abstract: The present study was conducted to screen the efficacy of curcumin against chloroquine phosphate (CQ)-induced reproductive toxicity in adult male Swiss albino mice. Animals were given oral doses of 100, 200, 300 mg/kg body weight (b.w.), and high dose of CQ (300 mg/kg b.w.) + curcumin (80 mg/kg b.w.) for 45 days. Animals of the withdrawal group were given high dose of CQ (300 mg/kg b.w.) for 45 days and, at day 46, were kept for another 45 days. Effects were observed on some key enzymes, such as alkaline phosphatase, which was found to be decreased, whereas acid phosphatase was increased and succinate dehydrogenase and adenosine triphosphatase were decreased. Oxidative parameters, such as superoxide dismutase declined, whereas thiobarbituric acid-reactive substances were found to be elevated. Protein level was also decreased. Gravimetric indices were also recorded. Results obtained indicated adverse effects of CQ in a dose-dependent manner. The presence of curcumin with CQ alleviated its toxic effects. Hence, it can be concluded that curcumin has beneficial influences and appears able to ameliorate CQ toxicity.
authors.affiliation: Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, India. ketalak60@yahoo.co.in
authors.forename: Ketaki R
authors.initials: KR
authors.lastname: Desai
authors.forename: Jignasa J
authors.initials: JJ
authors.lastname: Dattani
authors.forename: Dhrupad K
authors.initials: DK
authors.lastname: Rajput
authors.forename: Nilofar
authors.initials: N
authors.lastname: Moid
authors.forename: Hyacinth N
authors.initials: HN
authors.lastname: Highland
authors.forename: Linzbuoy B
authors.initials: LB
authors.lastname: George
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000962:Antimalarials / Q000633:toxicity*; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000633:toxicity; D003474:Curcumin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011897:Random Allocation; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000962:Antimalarials; D004791:Enzyme Inhibitors; D017392:Thiobarbituric Acid Reactive Substances; C023676:chloroquine diphosphate; D002738:Chloroquine; D013482:Superoxide Dismutase; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; D003474:Curcumin