title: Systems biology of JAK-STAT signalling in human malignancies.
abstract: Originally implicated in the regulation of survival, proliferation and differentiation of haematopoietic cells, the JAK-STAT pathway has also been linked to developmental processes, growth control and maintenance of homeostasis in a variety of other cells and tissues. Although it remains a complex system, its relative simplicity and the availability of molecular data makes it particularly attractive for modelling approaches. In this review, we will focus on JAK-STAT signalling in the context of cancer and present efforts to investigate signalling dynamics with the help of mathematical models. We describe the modelling workflow that realises a systems biology approach and give an example for interferon-γ signalling in pancreatic stellate cells.
authors.affiliation: Department of Systems Biology & Bioinformatics, University of Rostock, 18051 Rostock, Germany. julio.vera@uni-rostock.de
authors.forename: Julio
authors.initials: J
authors.lastname: Vera
authors.forename: Katja
authors.initials: K
authors.lastname: Rateitschak
authors.forename: Falko
authors.initials: F
authors.lastname: Lange
authors.forename: Christina
authors.initials: C
authors.lastname: Kossow
authors.forename: Olaf
authors.initials: O
authors.lastname: Wolkenhauer
authors.forename: Robert
authors.initials: R
authors.lastname: Jaster
mesh_terms: D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D053612:Janus Kinases / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D058954:Pancreatic Stellate Cells / Q000201:enzymology / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D049490:Systems Biology / Q000379:methods*
chemical_list: D050791:STAT Transcription Factors; D007371:Interferon-gamma; D053612:Janus Kinases