title: Co-ordination of incoming and outgoing traffic in antigen-presenting cells by pattern recognition receptors and T cells.
abstract: Dendritic cells are innate sentinels of the immune system and potent activators of naÏve T cells. Mechanisms must exist to enable these cells to achieve maximal activation of T cells specific for microbial antigens, while avoiding activation of T cells specific for self-antigens. Here we discuss how a combination of signals from pattern recognition receptors and T cells co-ordinates subcellular trafficking of antigen with both major histocompatibility complex class I and class II molecules and T-cell costimulatory molecules, resulting in the preferential presentation of microbial peptides within a stimulatory context.
authors.affiliation: Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Nair
authors.forename: Derk
authors.initials: D
authors.lastname: Amsen
authors.forename: J Magarian
authors.initials: JM
authors.lastname: Blander
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D051192:Receptors, Pattern Recognition / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D051192:Receptors, Pattern Recognition