title: The association between thyroid hormones and arterial stiffness in peritoneal dialysis patients.
abstract: OBJECTIVE
  The association between thyroid hormones and arterial stiffness is unclear. In this study, we investigated, for the first time in a large cohort of euthyroid peritoneal dialysis patients, the relationship between thyroid hormone levels and arterial stiffness.
  
  
  METHODS
  Fifty-seven patients were enrolled. Serum TSH, free T3 and free T4 levels were measured by chemiluminescence immunoassay method. Pulse wave analysis [augmentation index (AIx) and subendocardial viability ratio (SEVR)] were measured to assess arterial stiffness.
  
  
  RESULTS
  Mean age was 49 ± 12.3 years, and 56.1% were female. Mean TSH, fT3 and fT4 levels were 1.97 ± 0.99 mIU/ml, 2.80 ± 0.42 pg/ml and 1.22 ± 0.16 ng/dl, respectively. Mean AIx and SEVR were 22.3 ± 11.3 and 136 ± 21%, respectively. AIx was negatively correlated with residual urine volume (r = -0.372, P: 0.03) and fT3 levels (r = -0.382, P: 0.005). SEVR was correlated only with TSH level (r = -0.394, P: 0.003). In linear regression analysis adjusted for age, gender, history of diabetes and cardiovascular disease and residual diuresis, fT3 level (t = -3.949, P < 0.001) remained associated with AIx. Only TSH level (t = -2.409, P: 0.02) was related to SEVR.
  
  
  CONCLUSIONS
  Low serum fT3 level is associated with arterial stiffness, and high TSH level within the normal range is related to lower SEVR in euthyroid PD patients.
authors.affiliation: Division of Nephrology, Ege University School of Medicine, 35100 Bornova, Izmir, Turkey. etatar@hotmail.com
authors.forename: Erhan
authors.initials: E
authors.lastname: Tatar
authors.forename: Meltem
authors.initials: M
authors.lastname: Sezis Demirci
authors.forename: Fatih
authors.initials: F
authors.lastname: Kircelli
authors.forename: Ozkan
authors.initials: O
authors.lastname: Gungor
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yaprak
authors.forename: Gulay
authors.initials: G
authors.lastname: Asci
authors.forename: Ali
authors.initials: A
authors.lastname: Basci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozkahya
authors.forename: Ercan
authors.initials: E
authors.lastname: Ok
mesh_terms: D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D002339:Carotid Arteries / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D016231:Fluorescence Polarization Immunoassay; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D015995:Prevalence; D012372:ROC Curve; D012307:Risk Factors; D019722:Sphygmomanometers; D013963:Thyroid Hormones / Q000097:blood*; D014421:Turkey / Q000453:epidemiology; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers; D013963:Thyroid Hormones