title: Psilostachyin, acetylated pseudoguaianolides and their analogues: preparation and evaluation of their anti-inflammatory potential.
abstract: Naturally occurring acetylated pseudoguaianolides and psilostachyin including their analogues were synthesized. The structure of semi-synthetic psilostachyin was also confirmed by X-ray crystallography. The anti-inflammatory potential of all the derivatives has been evaluated through in vitro expression of TNF-α, IL-1β and IL-6 in murine neutrophils.
authors.affiliation: Natural Product Microbes Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, J&K, India.
authors.forename: Renu
authors.initials: R
authors.lastname: Chib
authors.forename: Bhahwal Ali
authors.initials: BA
authors.lastname: Shah
authors.forename: Naveen
authors.initials: N
authors.lastname: Anand
authors.forename: Anjali
authors.initials: A
authors.lastname: Pandey
authors.forename: Kamini
authors.initials: K
authors.lastname: Kapoor
authors.forename: Sarang
authors.initials: S
authors.lastname: Bani
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Gupta
authors.lastname: Rajnikant
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Sethi
authors.forename: Subhash Chandra
authors.initials: SC
authors.lastname: Taneja
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D053583:Interleukin-1beta / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D053583:Interleukin-1beta; D015850:Interleukin-6; D007783:Lactones; D012717:Sesquiterpenes; D014409:Tumor Necrosis Factor-alpha; C568085:psilostachyin A