title: B1 and B2 Sox gene expression during neural plate development in chicken and mouse embryos: universal versus species-dependent features.
abstract: Cumulative evidence now indicates pivotal roles for the group B1 Sox genes, Sox1, Sox2 and Sox3 in the genesis and development of neural primordia. Shared functions for the Sox1, Sox2 and Sox3 protein products have also been indicated. This emphasizes the importance and integral role of the group B1 Sox genes in regulating the neural primordia. We here review what is currently known about the expression patterns of both the group B1 Sox genes and the related group B2 Sox21 gene during the embryonic stages when the neural plate develops. These expression profiles are compared between the chicken and mouse embryos, both representatives of amniote species. This comparison indicates a gross conservation of the regulation of individual Sox genes, yet also demonstrates the existence of species-dependent variations, which should be taken into account when data from different species are being compared. To link the expression patterns and transcriptional regulation of these genes, contribution of gene-specific enhancers are discussed. The regulation of B1 Sox genes in the axial stem cells, the common precursors to the posterior neural plate and paraxial mesoderm and located at the posterior end of developing neural plate, is also highlighted in this review. This article thus provides a guide to performing readouts of B1/B2 Sox expression data during neural plate development in amniotes.
authors.affiliation: Graduate School of Frontier Biosciences, Osaka University, Yamadaoka, Suita, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Uchikawa
authors.forename: Megumi
authors.initials: M
authors.lastname: Yoshida
authors.forename: Makiko
authors.initials: M
authors.lastname: Iwafuchi-Doi
authors.forename: Kazunari
authors.initials: K
authors.lastname: Matsuda
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ishida
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takemoto
authors.forename: Hisato
authors.initials: H
authors.lastname: Kondoh
mesh_terms: D000818:Animals; D002642:Chick Embryo; D004622:Embryo, Mammalian / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D047108:Embryonic Development; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D008648:Mesoderm / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D051379:Mice; D054258:Neural Plate / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D055748:SOXB1 Transcription Factors / Q000235:genetics* / Q000378:metabolism; D055749:SOXB2 Transcription Factors / Q000235:genetics* / Q000378:metabolism; D013045:Species Specificity
chemical_list: D055748:SOXB1 Transcription Factors; D055749:SOXB2 Transcription Factors; C098693:Sox1 protein, mouse; C527783:Sox2 protein, mouse; C484490:Sox21 protein, Gallus gallus