title: Acute renal failure and hypercalcemia as onset in splenic lymphoma.
abstract: Hypercalcemia is a rare metabolic disorder in course of B cell lymphoma. The mechanism of hypercalcemia in patients with malignancy may include the increased extrarenal production of vitamin D from tumoral cells or neighboring macrophages, i-PTH or PTHrP from tumoral cells. In this case we reported a 34 years old caucasian woman with acute renal failure and hypercalcemia as onset of splenic lymphoma in absence of abnormal levels of serum vitamin D and PTHrP. Because of dramatic recovery of renal function and hypercalcemia after splenectomy, we can speculate that main mechanism of hypercalcemia is related to vitamin D production from neighboring lymphoma macrophages.
authors.affiliation: Department of Clinical Medicine, School of Medicine, Sapienza University, Rome, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Gasperini
authors.forename: A
authors.initials: A
authors.lastname: Gigante
authors.forename: B
authors.initials: B
authors.lastname: Barbano
authors.forename: M
authors.initials: M
authors.lastname: Liberatori
authors.forename: R
authors.initials: R
authors.lastname: Cianci
authors.forename: A
authors.initials: A
authors.lastname: Amoroso
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000097:blood; D017024:Chemotherapy, Adjuvant; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C470125:PTH protein, human; D010281:Parathyroid Hormone; D003404:Creatinine; D002117:Calcitriol; D002118:Calcium