title: Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs.
abstract: Poorly water-soluble drugs, such as phenylephrine, offer challenging problems for buccal drug delivery. In order to overcome these problems, particle size reduction (to the nanometer range) and cyclodextrin complexation were investigated for permeability enhancement. The apparent solubility in water and the buccal permeation of the original phenylephrine coarse powder, a phenylephrine-cyclodextrin complex and phenylephrine nanosuspensions were characterized. The particle size and particle surface properties of phenylephrine nanosuspensions were used to optimize the size reduction process. The optimized phenylephrine nanosuspension was then freeze dried and incorporated into a multi-layered buccal patch, consisting of a small tablet adhered to a mucoadhesive film, yielding a phenylephrine buccal product with good dosage accuracy and improved mucosal permeability. The design of the buccal patch allows for drug incorporation without the need to change the mucoadhesive component, and is potentially suited to a range of poorly water-soluble compounds.
authors.affiliation: Sansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide.
authors.forename: Shasha
authors.initials: S
authors.lastname: Rao
authors.forename: Yunmei
authors.initials: Y
authors.lastname: Song
authors.forename: Frank
authors.initials: F
authors.lastname: Peddie
authors.forename: Allan M
authors.initials: AM
authors.lastname: Evans
mesh_terms: D000042:Absorption; D000278:Administration, Buccal; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003505:Cyclodextrins / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure*; D010316:Particle Size; D010539:Permeability; D010656:Phenylephrine / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility; D013552:Swine
chemical_list: D003505:Cyclodextrins; D010656:Phenylephrine