title: Heterogeneous expression of Src tyrosine kinases Lyn, Fyn and Syk in classical Hodgkin lymphoma: prognostic implications.
abstract: The aim of this study was to determine the prognostic significance of the expression of Lyn, Fyn and Syk in Hodgkin lymphoma and its correlation with Epstein-Barr virus (EBV) infection. With this in mind, 96 patients with classical Hodgkin lymphoma were immunohistochemically evaluated for Lyn, Fyn and Syk expression in Hodgkin and Reed-Sternberg cells, and the results were correlated with the presence of EBV and patient outcomes. These three kinases were heterogeneously expressed in classical Hodgkin lymphoma cases. As there are no cut-offs established for these antibodies, they were introduced as continuous variables in the model. Statistical analysis showed that the expression of Syk and Fyn was significantly associated with shorter failure-free survival. Syk and Fyn may be useful to predict at diagnosis the treatment response of patients with classical Hodgkin lymphoma. There was a significant association between EBV infection and Lyn expression (p < 0.05). Overexpression of Syk and the availability of Syk inhibitors suggest that this molecule might be a therapeutic strategy worthy of development for cases expressing this molecule.
authors.affiliation: Department of Molecular Pathology, Puerta de Hierro University Hospital, Madrid, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Martín
authors.forename: Clara
authors.initials: C
authors.lastname: Salas
authors.forename: Mariano
authors.initials: M
authors.lastname: Provencio
authors.forename: Victor
authors.initials: V
authors.lastname: Abraira
authors.forename: Carmen
authors.initials: C
authors.lastname: Bellas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000378:metabolism / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006689:Hodgkin Disease / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000706:statistics & numerical data; D017403:In Situ Hybridization; D047908:Intracellular Signaling Peptides and Proteins; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis*; D051076:Proto-Oncogene Proteins c-fyn / Q000096:biosynthesis*; D012367:RNA, Viral / Q000235:genetics; D016539:Reed-Sternberg Cells / Q000378:metabolism / Q000473:pathology; D000072377:Syk Kinase; D055815:Young Adult; D019061:src-Family Kinases / Q000096:biosynthesis*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D012367:RNA, Viral; D011505:Protein-Tyrosine Kinases; C494957:FYN protein, human; D051076:Proto-Oncogene Proteins c-fyn; C000606896:SYK protein, human; D000072377:Syk Kinase; C060902:lyn protein-tyrosine kinase; D019061:src-Family Kinases