title: Malondialdehyde in exhaled breath condensate as a marker of oxidative stress in different pulmonary diseases.
abstract: BACKGROUND
  Oxidative stress plays a role in the pathogenesis of many chronic inflammatory lung diseases. Exhaled breath condensate (EBC) collection is a noninvasive method to investigate pulmonary oxidative stress biomarkers such as malondialdehyde (MDA).
  
  
  METHODS
  We measured MDA levels in EBC in a large number of patients (N = 194) with respiratory diseases: asthma (N = 64), bronchiectasis (BE, N = 19), chronic obstructive pulmonary disease (COPD, N = 73), idiopathic pulmonary fibrosis (IPF, N = 38). Fourteen healthy nonsmoking subjects were included as controls.
  
  
  RESULTS
  Excluding IPF subjects, MDA levels were significantly higher in all disease groups than in control group. MDA was significantly higher in COPD than asthmatic and BE subjects. Among asthmatics, corticosteroids-treated subjects had lower MDA levels than untreated subjects. COPD subjects showed an inverse correlation between MDA concentrations and FEV(1)% (rho:  -0.24, P < .05).
  
  
  CONCLUSIONS
  EBC-MDA is increased in subjects with chronic airway disorders, particularly in COPD, and it is related to FEV(1) reduction.
authors.affiliation: Cardiothoracic and Vascular Department, University of Pisa, Ospedale di Cisanello, Via Paradisa 2, 56124 Pisa, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Bartoli
authors.forename: F
authors.initials: F
authors.lastname: Novelli
authors.forename: F
authors.initials: F
authors.lastname: Costa
authors.forename: L
authors.initials: L
authors.lastname: Malagrinò
authors.forename: L
authors.initials: L
authors.lastname: Melosini
authors.forename: E
authors.initials: E
authors.lastname: Bacci
authors.forename: S
authors.initials: S
authors.lastname: Cianchetti
authors.forename: F L
authors.initials: FL
authors.lastname: Dente
authors.forename: A
authors.initials: A
authors.lastname: Di Franco
authors.forename: B
authors.initials: B
authors.lastname: Vagaggini
authors.forename: P L
authors.initials: PL
authors.lastname: Paggiaro
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D001944:Breath Tests; D045853:Exhalation; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis*; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D013183:Sputum / Q000737:chemistry
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde