title: Cutaneous manifestations of deep mycosis: an experience in a tropical pathology laboratory.
abstract: BACKGROUND
  Cutaneous manifestations of deep mycotic infection are fraught with delayed or misdiagnosis from mainly cutaneous neoplastic lesions.
  
  
  OBJECTIVE
  This study is designed to present our experience of these mycoses in a pathology laboratory in the tropics.
  
  
  METHODS
  A clinicopathologic analysis of deep mycotic infections was conducted over a 15 years period Formalin fixed and paraffin wax processed biopsies were stained with hematoxylin and eosin, periodic acid Schiff (PAS), and Grocott's methenamine silver (GMS) for the identification of fungus specie. Patients' bio-data and clinical information were obtained from records.
  
  
  RESULTS
  Twenty males and seven females presented with 6 months to 6 years histories of varying symptoms of slow growing facial swellings, nodules, subcutaneous frontal skull swelling, proptosis, nasal blockage, epistaxis, discharging leg sinuses, flank mass, convulsion and pain. Of the 27 patients, four gave antecedent history of trauma, two had recurrent lesions which necessitated maxilectomy, two presented with convulsion without motor dysfunction while one had associated erosion of the small bones of the foot. None of the patients had debilitating illnesses such as diabetes mellitus, tuberculosis, and HIV infection. Tissue histology revealed histoplasmosis (10), mycetoma (9), subcutaneous phycomycosis (6), and phaeohyphomycosis (2).
  
  
  CONCLUSIONS
  Deep mycoses may present primarily as cutaneous lesions in immunocompetent persons and often elicit distinct histologic inflammatory response characterized by granuloma formation. Diagnosis in resource constraint setting can be achieved with tissue stained with PAS and GMS which identifies implicated fungus. Clinical recognition and adequate knowledge of the pathology of these mycoses may reduce attendant patient morbidity.
authors.affiliation: Department of Pathology/Morbid Anatomy, Ahmadu Bello University and Ahmadu Bello, University Teaching Hospital, Shika-Zaria, 810001, Nigeria.
authors.forename: Modupeola Omotara
authors.initials: MO
authors.lastname: Samaila
authors.forename: Kabiru
authors.initials: K
authors.lastname: Abdullahi