title: Differential regional expression of multiple ADAMs during feather bud formation.
abstract: The expression of seven members of the ADAM family was investigated by in situ hybridization in the developing feather buds of chicken. The expression profiles of the ADAMs in the cells and tissues of the feather buds differ from each other. ADAM9, ADAM10, and ADAM17 are expressed in the epidermis of the feather bud, whereas ADAM23 expression is restricted to the bud crest, with a distribution similar to that of sonic hedgehog. ADAM13 is not only expressed in the epidermis, but also in restricted regions of the dermis. Both ADAM12 and ADAM22 are expressed in the dermis of the feather bud, with an opposite mediolateral and anteroposterior polarity. Furthermore, the mRNAs of all investigated ADAMs show regional differences in their expression, for example, in the neck and in the roots of the leg and wing. These results suggest that ADAMs play a variety of roles during avian feather bud formation.
authors.affiliation: Institute of Anatomy I, University of Jena School of Medicine, Jena University Hospital, Jena, Germany.
authors.forename: Juntang
authors.initials: J
authors.lastname: Lin
authors.forename: Jiankai
authors.initials: J
authors.lastname: Luo
authors.forename: Christoph
authors.initials: C
authors.lastname: Redies
mesh_terms: D051722:ADAM Proteins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002645:Chickens; D005241:Feathers / Q000196:embryology* / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization
chemical_list: D051722:ADAM Proteins