title: Steroid-unresponsive hypereosinophilic syndrome.
abstract: Hypereosinophilic syndrome in children is rare and is characterised by sustained over-production of eosinophils. An 11-year-old boy was diagnosed with hypereosinophilic syndrome as per standard criteria. He was treated initially with intravenous methylprednisolone, followed by oral prednisolone, to which he showed a limited response. The highest absolute eosinophil count was 27.0×10(9)/L. He was commenced on imatinib mesylate but, because of no response, he was switched to hydroxyurea combined with low-dose prednisolone to which he showed improvement with decreasing levels of eosinophils.
authors.affiliation: Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, CHILDS Trust Medical Research Foundation, Chennai, India. drarathi@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Srinivasan
authors.forename: R
authors.initials: R
authors.lastname: Lavanya
authors.forename: J
authors.initials: J
authors.lastname: Sankar
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001549:Benzamides; D002648:Child; D004359:Drug Therapy, Combination / Q000379:methods; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D000068877:Imatinib Mesylate; D008297:Male; D010879:Piperazines / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D011743:Pyrimidines / Q000008:administration & dosage; D013256:Steroids / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D013256:Steroids; D000068877:Imatinib Mesylate; D011239:Prednisolone; D006918:Hydroxyurea