title: Temporal trends in cardiomyopathy in pregnancy and association with feto-infant morbidity outcomes.
abstract: OBJECTIVE
  To examine temporal trends of cardiomyopathy in pregnancy and its association with feto-infant morbidity outcomes.
  
  
  METHODS
  We performed a population-based retrospective cohort analysis utilizing the Florida hospital discharge data linked to vital statistics for 1998 to 2007 (N = 1 738 860). Prevalence rates and trend statistics of cardiomyopathy were computed. Conditional logistic regression models were used to generate adjusted odds ratios (AOR) and 95% confidence intervals (CI).
  
  
  RESULTS
  The annual prevalence of cardiomyopathy in pregnancy increased from 8.5/100 000 births to 32.7/100 000 (p for trend <0.0001), representing an absolute increase of 24% and a relative increase of 300% over the decade. Infants born to women with cardiomyopathy were at higher risk for feto-infant morbidities, including low birth weight (AOR = 3.49, 95% CI: 2.97-4.11), very low birth weight (AOR = 4.43, 95% CI: 2.98-6.60), preterm birth (AOR = 3.33, 95% CI: 2.88-3.85), very preterm birth (AOR = 5.22, 95% CI: 3.92-6.97) and small for gestational age (AOR = 1.57, 95% CI: 1.26-1.96).
  
  
  CONCLUSIONS
  The observed increasing prevalence of cardiomyopathy during pregnancy over the decade is of concern, as it is related to elevated risk for feto-infant morbidities. There is a need to delineate risk factors for this condition and to formulate appropriate preconception counseling for women with elevated risk for this diagnosis.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, USA.
authors.forename: Valerie E
authors.initials: VE
authors.lastname: Whiteman
authors.forename: Hamisu M
authors.initials: HM
authors.lastname: Salihu
authors.forename: Hanna E
authors.initials: HE
authors.lastname: Weldeselasse
authors.forename: Euna M
authors.initials: EM
authors.lastname: August
authors.forename: Amina P
authors.initials: AP
authors.lastname: Alio
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Marty
mesh_terms: D000328:Adult; D009202:Cardiomyopathies / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology*; D005431:Florida / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology*; D009017:Morbidity / Q000639:trends; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D013997:Time Factors