title: [Retrospective analysis of antiemetic effect in patients receiving cisplatin].
abstract: We retrospectively examined the results of antiemetic therapy with granisetron and dexamethasone; with granisetron, dexamethasone and aprepitant; and with palonosetron, dexamethasone and aprepitant, in patients who received chemotherapy with cisplatin at 50 mg/m2 or more for the first time. Vomiting was dramatically reduced by the concomitant administration of aprepitant. There was no difference in this effect when palonosetron was used instead of granisetron as a serotonin receptor antagonist. There was also no significant difference in the percentage of patients without nausea among the 3 groups. The results of this study indicate that vomiting in patients receiving chemotherapy can be controlled using aprepitant in combination with two other drugs.
authors.affiliation: Pharmacy Division, National Cancer Center Hospital East, Japan.
authors.forename: Masahito
authors.initials: M
authors.lastname: Yonemura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Akita
authors.forename: Shinya
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kouichi
authors.initials: K
authors.lastname: Gotoh
authors.forename: Makoto
authors.initials: M
authors.lastname: Tahara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohtsu
authors.forename: Yuuichirou
authors.initials: Y
authors.lastname: Ohe
authors.forename: Kiminori
authors.initials: K
authors.lastname: Mouri
authors.forename: Keishirou
authors.initials: K
authors.lastname: Izumi
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000077608:Aprepitant; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use*; D009325:Nausea / Q000517:prevention & control; D012189:Retrospective Studies; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D009025:Morpholines; D000077608:Aprepitant; D002945:Cisplatin