title: Platelet rich plasma for the prevention of osteoradionecrosis. A double blinded randomized cross over controlled trial.
abstract: Osteoradionecrosis of the jaws is a complication of radiotherapy and controversy remains about the management of teeth in the field of radiotherapy. Platelet rich plasma has been advocated in multiple surgical sites, both bone and soft tissue, to promote healing and reduce complications. A randomized double blinded controlled trial was performed on patients receiving bilateral radiotherapy that affected the mandible who required pre treatment dental extractions. One side received platelet rich plasma and the other acted as a control. Twenty-two patients were recruited over 12 months and over a 5-year period following treatment three developed osteoradionecrosis (14%). Platelet rich plasma failed to show any benefit in the prevention of osteoradionecrosis. Nor was there any benefit in pain scores or mucosal healing on sides that were treated with platelet rich plasma. Platelet rich plasma fails to show a benefit in the prevention of osteoradionecrosis. The rate of osteoradionecrosis is high compared to other published series and the prophylactic removal of molar teeth should be questioned as a preventative measure.
authors.affiliation: Maxillofacial Unit, Royal Brisbane Hospital, Herston 4029, QLD, Australia. martin_batstone@health.qld.gov.au
authors.forename: M D
authors.initials: MD
authors.lastname: Batstone
authors.forename: J
authors.initials: J
authors.lastname: Cosson
authors.forename: L
authors.initials: L
authors.lastname: Marquart
authors.forename: C
authors.initials: C
authors.lastname: Acton
mesh_terms: D000328:Adult; D000368:Aged; D000543:Alveoloplasty / Q000379:methods; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy; D008297:Male; D008334:Mandible / Q000473:pathology / Q000528:radiation effects; D008336:Mandibular Diseases / Q000517:prevention & control*; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000517:prevention & control*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology; D010610:Pharyngeal Neoplasms / Q000532:radiotherapy; D053657:Platelet-Rich Plasma / Q000502:physiology*; D011879:Radiotherapy Dosage; D014081:Tooth Extraction; D020390:Tooth Socket / Q000473:pathology / Q000528:radiation effects