title: Orocecal transit time and small intestinal bacterial overgrowth in type 2 diabetes patients from North India.
abstract: BACKGROUND
  Diarrhea, constipation, flatulence, and abdominal pain are common complaints in type 2 diabetes patients. Impaired intestinal motility is often followed by small intestinal bacterial overgrowth (SIBO). Therefore, this study was planned to determine the incidence of SIBO and its relation with orocecal transit time (OCTT) in type 2 diabetes patients.
  
  
  METHODS
  SIBO and OCTT were measured by using noninvasive glucose and lactulose hydrogen breath tests, respectively. For this study, 84 patients with type 2 diabetes mellitus in the age range 30-65 years and 45 age-matched apparently healthy controls were enrolled.
  
  
  RESULTS
  The glucose hydrogen breath test was suggestive of SIBO in 15.5% of patients with type 2 diabetes mellitus but in one (2.2%) of controls. There was a significant increase (P<0.001) in OCTT in type 2 diabetes patients compared with controls. It was also observed that OCTT in type 2 diabetes patients with SIBO was significantly delayed (P<0.001) compared with type 2 diabetes patients without SIBO.
  
  
  CONCLUSIONS
  This study indicates that SIBO in diabetes patients may be due to delayed OCTT.
authors.affiliation: Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. svrana25@hotmail.com
authors.forename: Satyavati
authors.initials: S
authors.lastname: Rana
authors.forename: Anil
authors.initials: A
authors.lastname: Bhansali
authors.forename: Sanjay
authors.initials: S
authors.lastname: Bhadada
authors.forename: Surendra
authors.initials: S
authors.lastname: Sharma
authors.forename: Jaspreet
authors.initials: J
authors.lastname: Kaur
authors.forename: Kartar
authors.initials: K
authors.lastname: Singh
mesh_terms: D000328:Adult; D000368:Aged; D001765:Blind Loop Syndrome / Q000209:etiology* / Q000503:physiopathology*; D001944:Breath Tests / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D007194:India; D007421:Intestine, Small / Q000503:physiopathology*; D007792:Lactulose / Q000378:metabolism; D008297:Male; D008697:Methane / Q000032:analysis; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D007792:Lactulose; D006859:Hydrogen; D005947:Glucose; D008697:Methane