title: Three new cycloartane triterpenoids from Astragalus bicuspis.
abstract: Three new cycloartane triterpenoids have been isolated from Astragalus bicUSPIS Fisch. Their structures were elucidated as 23(R),24(S),25( R),26(S)-16 β/23,23/26,24/25-triepoxy-26-hydroxy-9,19-cyclolanosta-3,6-dione (1), 6 α,23,24,25-tetraol-16 β-acetoxy-23(R),24(R)-9,19-cyclanosta-3-one (2), and 6 α,23,24,25-tetraol-16 β-acetoxy-23(R),24(R)-9,19-cyclolanosta-3 β- O-xyloside (3), based on their spectroscopic analysis. All cycloartane tritepenoids exhibited weak cytotoxicities against 3T3 fibroblast cells as compared to the standard drug cycloheximide. Compounds 3 and 4 were also tested for their antileishmanial potential, and a weak activity was observed against promastigotes of Leishmania major.
authors.affiliation: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
authors.forename: Saleem
authors.initials: S
authors.lastname: Jan
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abbaskhan
authors.forename: Syed Ghulam
authors.initials: SG
authors.lastname: Musharraf
authors.forename: Samina A
authors.initials: SA
authors.lastname: Sattar
authors.forename: Saud I
authors.initials: SI
authors.lastname: Resayes
authors.forename: Zeid A
authors.initials: ZA
authors.lastname: Al-Othman
authors.forename: Abdullah M
authors.initials: AM
authors.lastname: Al-Majid
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027883:Astragalus Plant / Q000737:chemistry*; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D020128:Inhibitory Concentration 50; D018320:Leishmania major / Q000187:drug effects; D008519:Medicine, Traditional; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C579582:6alpha,23,24,25-tetraol-16beta-acetoxy-23(R),24(R)-9,19-cyclanosta-3-one; D000981:Antiprotozoal Agents; D010936:Plant Extracts; D014315:Triterpenes; C085352:cycloartane