title: Abnormal neural activities in first-episode, treatment-naïve, short-illness-duration, and treatment-response patients with major depressive disorder: a resting-state fMRI study.
abstract: BACKGROUND
  Abnormality of limbic-cortical networks was postulated in depression. Using a regional homogeneity (ReHo) approach, we explored the regional homogeneity (ReHo) of the brain regions in patients with first-episode, treatment-naïve, short-illness-duration, and treatment-response depression in resting state to test the abnormality hypothesis of limbic-cortical networks in major depressive disorder (MDD).
  
  
  METHODS
  Seventeen patients with treatment-response MDD and 17 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans.
  
  
  RESULTS
  
  
  
  CONCLUSIONS
  Our findings suggested the abnormality of limbic-cortical networks in first-episode, treatment-naïve, short-illness-duration, and treatment-response MDD patients, and added an expanding literature to the abnormality hypothesis of limbic-cortical networks in MDD.
authors.affiliation: Mental Health Center, First Affiliated Hospital, Guangxi Medical University; Nanning, Guangxi 530021, China.
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Guo
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Xue
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: Chao-qiong
authors.initials: CQ
authors.lastname: Ma
authors.forename: Chang-lian
authors.initials: CL
authors.lastname: Tan
authors.forename: Xue-li
authors.initials: XL
authors.lastname: Sun
authors.forename: Jin-dong
authors.initials: JD
authors.lastname: Chen
authors.forename: Zhe-ning
authors.initials: ZN
authors.lastname: Liu
authors.forename: Chang-qing
authors.initials: CQ
authors.lastname: Xiao
authors.forename: Hua-fu
authors.initials: HF
authors.lastname: Chen
authors.forename: Jing-ping
authors.initials: JP
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D003863:Depression; D003866:Depressive Disorder; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008032:Limbic System / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D016896:Treatment Outcome; D055815:Young Adult