title: A randomised clinical trial to assess maintenance of gingival health by a novel gel to foam dentifrice containing 0.1%w/w o-cymen-5-ol, 0.6%w/w zinc chloride.
abstract: OBJECTIVE
  To assess the ability of 0.1%w/w o-cymen-5-ol/ 0.6%w/w zinc chloride gel to foam dentifrice to maintain gingival health compared to a sodium fluoride control dentifrice.
  
  
  METHODS
  Following a baseline examination, subjects went through a regimen to bring them to a high level of gingival health. This involved a professional dental prophylaxis supported by oral hygiene instruction prior to commencing study treatment. Subjects brushed twice daily for 12 weeks with either the test or control dentifrice. Examinations for gingival inflammation (MGI), bleeding and plaque were performed after 12 weeks.
  
  
  RESULTS
  205 subjects were included in the efficacy analysis. Relative to the sodium fluoride/ silica control dentifrice group the o-cymen-5-ol/ zinc chloride gel to foam dentifrice exhibited statistically significant reductions (p<0.0001) in MGI, bleeding and plaque of 32.2%, 26.3% and 20.7% respectively after 12 weeks.
  
  
  CONCLUSIONS
  The results of the present clinical study demonstrate that the use of the 0.1%w/w o-cymen-5-ol/ 0.6%w/w zinc chloride gel to foam dentifrice over a 12 week period provides a statistically significant benefit in maintaining gingival health compared to a sodium fluoride control dentifrice.
authors.affiliation: Global Health Research Group, New Delhi, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Kakar
authors.forename: Evelyn E
authors.initials: EE
authors.lastname: Newby
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Ghosh
authors.forename: Andrew
authors.initials: A
authors.lastname: Butler
authors.forename: Mary Lynn
authors.initials: ML
authors.lastname: Bosma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002712:Chlorides / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D003777:Dental Prophylaxis; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010636:Phenols / Q000627:therapeutic use*; D016037:Single-Blind Method; D012969:Sodium Fluoride / Q000627:therapeutic use; D055815:Young Adult; D017967:Zinc Compounds / Q000627:therapeutic use*
chemical_list: D002712:Chlorides; D003802:Dentifrices; D010636:Phenols; D017967:Zinc Compounds; C016837:zinc chloride; D012969:Sodium Fluoride; C512394:o-cymen-5-ol