title: Radically resected epithelioid angiosarcoma that originated in the mediastinum.
abstract: Angiosarcoma is a rare neoplasm, accounting for only 1%-2% of all sarcomas. It occurs most frequently in the skin and soft tissue and rarely in the thoracic region. To our knowledge, a mediastinal angiosarcoma is extremely rare. We report on the surgical resection of a rare case of giant epithelioid angiosarcoma originating in the anterior mediastinum, followed by six courses of adjuvant chemotherapy (doxorubicin + ifosfamide). The patient is alive and asymptomatic 1 year after surgery. As the prognosis for unresectable cases is generally dismal, surgical resection and adjuvant therapy can be an option for mediastinal angiosarcoma.
authors.affiliation: Department of Thoracic Surgery, Hyogo Cancer Center, 13-70 Kitaouji-cho, Akashi 673-8558, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Tane
authors.forename: Yugo
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Syunsuke
authors.initials: S
authors.lastname: Tauchi
authors.forename: Kazuya
authors.initials: K
authors.lastname: Uchino
authors.forename: Reiko
authors.initials: R
authors.lastname: Nakai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D004317:Doxorubicin / Q000008:administration & dosage; D015622:Epithelioid Cells / Q000473:pathology*; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007150:Immunohistochemistry; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D009361:Neoplasm Invasiveness; D049268:Positron-Emission Tomography; D056346:Sternotomy; D019616:Thoracic Surgical Procedures; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures
chemical_list: D004317:Doxorubicin; D007069:Ifosfamide