title: 31P MR spectroscopic imaging detects regenerative changes in human liver stimulated by portal vein embolization.
abstract: OBJECTIVE
  First, to evaluate hepatocyte phospholipid metabolism and energetics during liver regeneration stimulated by portal vein embolization (PVE) using proton-decoupled (31)P MR spectroscopic imaging ((31)P-MRSI). Second, to compare the biophysiologic differences between hepatic regeneration stimulated by PVE and by partial hepatectomy (PH).
  
  
  METHODS
  Subjects included six patients with hepatic metastases from colorectal cancer who were scheduled to undergo right PVE before definitive resection of right-sided tumor. (31)P-MRSI was performed on the left liver lobe before PVE and 48 h following PVE. Normalized quantities of phosphorus-containing hepatic metabolites were analyzed from both visits. In addition, MRSI data at 48 h following partial hepatectomy were compared with the data from the PVE patients.
  
  
  RESULTS
  At 48 h after PVE, the ratio of phosphomonoesters to phosphodiesters in the nonembolized lobe was significantly elevated. No significant changes were found in nucleoside triphosphates (NTP) and Pi values. The phosphomonoester (PME) to phosphodiester (PDE) ratio in regenerating liver 48 h after partial hepatectomy was significantly greater than PME/PDE 48 h after PVE.
  
  
  CONCLUSIONS
  (31)P-MRSI is a valid technique to noninvasively evaluate cell membrane metabolism following PVE. The different degree of biochemical change between partial hepatectomy and PVE indicates that hepatic growth following these two procedures does not follow the same course.
authors.affiliation: Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Qi
authors.forename: Amita
authors.initials: A
authors.lastname: Shukla-Dave
authors.forename: Yuman
authors.initials: Y
authors.lastname: Fong
authors.forename: Mithat
authors.initials: M
authors.lastname: Gönen
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Schwartz
authors.forename: William M
authors.initials: WM
authors.lastname: Jarnagin
authors.forename: Jason A
authors.initials: JA
authors.lastname: Koutcher
authors.forename: Kristen L
authors.initials: KL
authors.lastname: Zakian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002462:Cell Membrane / Q000378:metabolism; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006498:Hepatectomy / Q000379:methods; D022781:Hepatocytes / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010759:Phosphorus Isotopes / Q000494:pharmacology*; D011169:Portal Vein / Q000473:pathology*; D011522:Protons; D013053:Spectrophotometry / Q000379:methods; D013997:Time Factors
chemical_list: D010759:Phosphorus Isotopes; D011522:Protons