title: Agminated atypical Spitz tumor: large nasal lesion in a child with Down syndrome.
abstract: We present a 5-year-old girl with Down syndrome and a 2.5-cm agminated atypical Spitz tumor of the nose. Although atypical Spitz tumor has uncertain malignant potential, trisomy 21 is protective against melanoma. This is the first description of an atypical Spitz tumor in a patient with Down syndrome and the largest nasal lesion reported.
authors.affiliation: Department of Plastic and Oral Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Aladdin H
authors.initials: AH
authors.lastname: Hassanein
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Gellis
authors.forename: Birgitta A
authors.initials: BA
authors.lastname: Schmidt
authors.forename: Arin K
authors.initials: AK
authors.lastname: Greene
mesh_terms: D002675:Child, Preschool; D003937:Diagnosis, Differential; D060467:Disease Resistance; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics; D018332:Nevus, Epithelioid and Spindle Cell / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D009669:Nose Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D016038:Skin Transplantation