title: Homotropic and heterotropic interactions in cytochromes c(3) from sulphate reducing bacteria.
abstract: This article reviews the contribution of António Xavier and his associates to the study of multihaem cytochromes. Detailed analysis of interactions between the charges of the haems and protonatable groups reveals that electrostatic effects may be outweighed by subtle changes in conformation. This helps us to understand how tetrahaem cytochromes c(3) work and also gives an insight into the mechanism of cytochrome c oxidase.
authors.affiliation: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal.
authors.forename: David L
authors.initials: DL
authors.lastname: Turner
authors.forename: Teresa
authors.initials: T
authors.lastname: Catarino
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D003574:Cytochrome c Group / Q000737:chemistry* / Q000266:history* / Q000378:metabolism; D006418:Heme / Q000737:chemistry* / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010084:Oxidation-Reduction; D011174:Portugal; D011487:Protein Conformation; D013431:Sulfates / Q000378:metabolism; D013816:Thermodynamics
chemical_list: D001426:Bacterial Proteins; D003574:Cytochrome c Group; D013431:Sulfates; D006418:Heme; C017165:cytochrome c(3)