title: Photo-responsive polymer with erasable and reconfigurable micro- and nano-patterns: an in vitro study for neuron guidance.
abstract: The interaction of cells with nanoscale topography has proven to be an important modality in controlling cell responses. Topographic parameters on material surfaces play a role in cell growth. We have synthesized a new bio compatible polymer containing photoswitching molecules. Stripepatterned (groove/ridge pattern) were patterned and erased with ease on this bio azopolymer with two different set-ups: one with the projection of an optical interference pattern and the other one by molecular self-organization with one single laser beam. These two set-ups allow the re-writing of pattern after erasing and its inscription in vitro. PC12 cells were cultured on the bio-photoswitching patterned polymer and compared with PC12 cells growing on a well know substrate: poly-L-lysine. This result is of interest for facilitating contact guidance and designing reconfigurable scaffold for neural network formation in vitro.
authors.affiliation: Moltech Anjou, PRES UNAM, University of Angers, CNRS UMR 6200, Angers, France. regis.barille@univ-angers.fr
authors.forename: R
authors.initials: R
authors.lastname: Barillé
authors.forename: R
authors.initials: R
authors.lastname: Janik
authors.forename: S
authors.initials: S
authors.lastname: Kucharski
authors.forename: J
authors.initials: J
authors.lastname: Eyer
authors.forename: F
authors.initials: F
authors.lastname: Letournel
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000737:chemistry*; D016716:PC12 Cells; D010777:Photochemistry; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013499:Surface Properties
chemical_list: D011108:Polymers