title: Functional brain imaging with M/EEG using structured sparsity in time-frequency dictionaries.
abstract: Magnetoencephalography (MEG) and electroencephalography (EEG) allow functional brain imaging with high temporal resolution. While time-frequency analysis is often used in the field, it is not commonly employed in the context of the ill-posed inverse problem that maps the MEG and EEG measurements to the source space in the brain. In this work, we detail how convex structured sparsity can be exploited to achieve a principled and more accurate functional imaging approach. Importantly, time-frequency dictionaries can capture the non-stationary nature of brain signals and state-of-the-art convex optimization procedures based on proximal operators allow the derivation of a fast estimation algorithm. We compare the accuracy of our new method to recently proposed inverse solvers with help of simulations and analysis of real MEG data.
authors.affiliation: INRIA, Parietal team, Saclay, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Gramfort
authors.forename: Daniel
authors.initials: D
authors.lastname: Strohmeier
authors.forename: Jens
authors.initials: J
authors.lastname: Haueisen
authors.forename: Matti
authors.initials: M
authors.lastname: Hamalainen
authors.forename: Matthieu
authors.initials: M
authors.lastname: Kowalski
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000465:Algorithms; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D015225:Magnetoencephalography / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity