title: Manipulation of host membranes by bacterial effectors.
abstract: Bacterial pathogens interact with host membranes to trigger a wide range of cellular processes during the course of infection. These processes include alterations to the dynamics between the plasma membrane and the actin cytoskeleton, and subversion of the membrane-associated pathways involved in vesicle trafficking. Such changes facilitate the entry and replication of the pathogen, and prevent its phagocytosis and degradation. In this Review, we describe the manipulation of host membranes by numerous bacterial effectors that target phosphoinositide metabolism, GTPase signalling and autophagy.
authors.affiliation: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Hyeilin
authors.initials: H
authors.lastname: Ham
authors.forename: Anju
authors.initials: A
authors.lastname: Sreelatha
authors.forename: Kim
authors.initials: K
authors.lastname: Orth
mesh_terms: D001343:Autophagy; D001419:Bacteria / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology*; D002462:Cell Membrane / Q000378:metabolism / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D010716:Phosphatidylinositols / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D010716:Phosphatidylinositols