title: Effect of alkylphenols on adult male medaka: plasma vitellogenin goes up to the level of estrous female.
abstract: The effect that oral administration of four alkylphenols, (1) bisphenol A (BPA), (2) p-t-octylphenol (OP), (3) p-nonylphenol (NP) and (4) p-n-nonylphenol (n-NP), as well as 17α-ethynylestradiol (EE2) had on male medaka fish vitellogenin was investigated. The male medaka was fed diets containing different concentrations of these chemicals for 7 days, after which their plasma vitellogenin levels were measured. Vitellogenin levels up to ≈10(7) ng/ml were found. This value is close to that of the normal estrous female medaka. The median effective concentration (EC(50)) values resulting from BPA, OP, NP and EE2 in the diet were calculated as 1600, 2600, 940 and 0.37 μg/g diet, respectively.
authors.affiliation: School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1, Asahidai, Tatsunokuchi, Ishikawa 923-1292, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Chikae
authors.forename: Ryuzoh
authors.initials: R
authors.lastname: Ikeda
authors.forename: Quamrul
authors.initials: Q
authors.lastname: Hasan
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Morita
authors.forename: Eiichi
authors.initials: E
authors.lastname: Tamiya