title: Endothelium-independent dilation in children and adolescents.
abstract: Peak brachial artery dilation post-nitroglycerin (NTG) administration occurs between 3 and 5 min in adults. The purpose of this study was to identify the time to peak dilation response to sublingual NTG (0·3 mg) in youth. Endothelium-independent dilation (EID) was measured in 198 healthy (113 males, 85 females) youth (6-18 years) via ultrasound imaging of the brachial artery following NTG administration. Time to peak EID was 268 s following NTG administration, with no significant (P = 0·6) difference between males and females. There was a significant (P<0·001) difference between EID post-NTG at the 3 versus 4 min, 4 versus 5-min, and 3 versus 5 min time points. Peak EID (males: 24·8 ± 0·5 versus females: 25·3 ± 0·6%, P = 0·6) was not significantly different after accounting for baseline diameter. Peak response to NTG administration occurs between 4 and 5 min. The results demonstrate the importance of measuring EID up to 5-min post-NTG administration in youth.
authors.affiliation: Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA. marla010@umn.edu
authors.forename: Kara L
authors.initials: KL
authors.lastname: Marlatt
authors.forename: Meghan C
authors.initials: MC
authors.lastname: McCue
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Kelly
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Metzig
authors.forename: Julia
authors.initials: J
authors.lastname: Steinberger
authors.forename: Donald R
authors.initials: DR
authors.lastname: Dengel
mesh_terms: D000286:Administration, Sublingual; D000293:Adolescent; D000367:Age Factors; D000375:Aging; D000704:Analysis of Variance; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage*; D012737:Sex Factors; D013997:Time Factors; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin