title: α-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors.
abstract: As part of continued efforts to understand the mechanisms of 1,5-α-l-arabinanases better, some arabinan-like iminosugar oligosaccharides were synthesized. An iminosugar analogue of arabinobiose was found to be a good inhibitor of the arabinanase Arb93A from Fusarium graminearum. Structures were determined for complexes of this inhibitor with wild-type Arb93A and a catalytically inactive mutant.
authors.affiliation: School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
authors.forename: Ethan D
authors.initials: ED
authors.lastname: Goddard-Borger
authors.forename: Raphael
authors.initials: R
authors.lastname: Carapito
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Jeltsch
authors.forename: Vincent
authors.initials: V
authors.lastname: Phalip
authors.forename: Robert V
authors.initials: RV
authors.lastname: Stick
authors.forename: Annabelle
authors.initials: A
authors.lastname: Varrot
mesh_terms: D001089:Arabinose / Q000031:analogs & derivatives* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D008958:Models, Molecular; D011487:Protein Conformation; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D011759:Pyrrolidines; C431714:arabinofuranose; D001089:Arabinose; D006026:Glycoside Hydrolases; C434938:exo-alpha-L-arabinanase; C032519:pyrrolidine