title: Bilirubin dependence on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index.
abstract: In humans, bilirubin levels are influenced by different factors. This study evaluates how several nongenetic causes and the genetic UGT1A1 polymorphisms contribute for bilirubin levels, in a cohort of 146 young Caucasian females. Hematological data, bilirubin, screening of TA duplication in the UGT1A1 gene, body mass index (BMI) and body fat were determined. A questionnaire about fasting time, smoking habits, oral contraceptive therapy, caloric intake and physical activity was done. Participants were divided according to the tertiles of bilirubin. Subjects from the second and third tertile had significant rises in hemoglobin (Hb), hematocrit, mean cell Hb and mean cell Hb concentration, and a significant increased frequency for the c.-41_-40dupTA allele in homozygosity, when compared to the first tertile. Red blood cell count was significantly increased in the third tertile. Results showed that the c.-41_-40dupTA allele (genetic), Hb, BMI and fasting time (nongenetic) were the main factors associated bilirubin levels.
authors.affiliation: Department of Biological Sciences, Biochemistry Laboratory, Faculty of Pharmacy of Oporto University, Porto; Health College of Polytechnic Institute of Bragança, Bragança.
authors.forename: Carina
authors.initials: C
authors.lastname: Rodrigues
authors.affiliation: Institute of Health Sciences of Portuguese Catholic, Porto; Institute for Cellular and Molecular Biology, Oporto University, Porto, Portugal.
authors.forename: Elísio
authors.initials: E
authors.lastname: Costa
authors.affiliation: Molecular Genetics Unit, Institute of Medical Genetics Dr. Jacinto Magalhães INSARJ, Porto.
authors.forename: Emília
authors.initials: E
authors.lastname: Vieira
authors.affiliation: Molecular Genetics Unit, Institute of Medical Genetics Dr. Jacinto Magalhães INSARJ, Porto.
authors.forename: Rosário
authors.initials: R
authors.lastname: Santos
authors.affiliation: Gastroenterology Department, Centro Hospitalar de Vila Nova de Gaia.
authors.forename: João
authors.initials: J
authors.lastname: De Carvalho
authors.affiliation: Investigation Center for Health Sciences, University of Beira Interior, Covilhã.
authors.forename: Petronila
authors.initials: P
authors.lastname: Rocha-Pereira
authors.affiliation: Department of Biological Sciences, Biochemistry Laboratory, Faculty of Pharmacy of Oporto University, Porto; Institute for Cellular and Molecular Biology, Oporto University, Porto, Portugal.
authors.forename: Alice
authors.initials: A
authors.lastname: Santos-Silva
authors.affiliation: Department of Biological Sciences, Biochemistry Laboratory, Faculty of Pharmacy of Oporto University, Porto; Institute for Cellular and Molecular Biology, Oporto University, Porto, Portugal. Electronic address: elsa.rocha@ff.up.pt.
authors.forename: Elsa
authors.initials: E
authors.lastname: Bronze-da-Rocha
mesh_terms: D000293:Adolescent; D001663:Bilirubin / Q000097:blood* / Q000378:metabolism; D015992:Body Mass Index; D015331:Cohort Studies; D005215:Fasting; D005260:Female; D014453:Glucuronosyltransferase / Q000235:genetics*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D011110:Polymorphism, Genetic; D011174:Portugal; D011401:Promoter Regions, Genetic; D055815:Young Adult; D000099148:UGT1A1 Enzyme
chemical_list: D001663:Bilirubin; D014453:Glucuronosyltransferase; D006454:Hemoglobins; D000099148:UGT1A1 Enzyme