title: Evaluation of disk approximation and single-well broth tests for detection of inducible clindamycin resistance in Streptococcus pneumoniae.
abstract: This study evaluated an agar disk diffusion D-zone test and an erythromycin-clindamycin (ERY + CLI) single-well broth test for inducible CLI resistance in Streptococcus pneumoniae. The standard CLSI disk approximation test and a single-well combination test incorporating 1 plus 0.5 μg/ml ERY + CLI detected >96% of isolates containing the ermB determinant.
authors.affiliation: Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, USA. jorgensen@uthscsa.edu
authors.forename: James H
authors.initials: JH
authors.lastname: Jorgensen
authors.forename: M Leticia
authors.initials: ML
authors.lastname: McElmeel
authors.forename: Letitia C
authors.initials: LC
authors.lastname: Fulcher
authors.forename: Lesley
authors.initials: L
authors.lastname: McGee
authors.forename: Anita
authors.initials: A
authors.lastname: Glennen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D005798:Genes, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin