title: Decreased bone mineral density in young adults treated with SCT in childhood: the role of 25-hydroxyvitamin D.
abstract: We measured bone mineral density (BMD) with dual-energy X-ray absorptiometry in the total body, at the lumbar spine, at the femoral neck and in the total hip, in 18 young adults with a median of 18.2 years after SCT. Fifteen patients had undergone auto-SCT and all patients had received TBI. The patients had significantly lower BMD in the total body, at the femoral neck, and in the total hip compared with age- and sex-matched controls. Six of 18 patients (33%) had low bone mass (z-score <-1) at one or more measurement sites, as opposed to two of the controls (11%, P=0.29). We found no significant influence of growth hormone levels or of untreated hypogonadism on BMD variables. Levels of 25-hydroxy (25(OH)) vitamin D were lower among the patients (35.2 vs 48.8 nmol/L, P=0.044) and were significantly correlated with total body BMD in the patient group (r=0.55, P=0.021). All six patients with low bone mass had hypovitaminosis D (≤37 nmol/L as opposed to 4 of the 11 (36%) patients without low bone mass (P=0.035). In conclusion, we found decreased BMD in SCT survivors, which may in part be caused by 25(OH) vitamin D deficiency.
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Frisk
authors.forename: J
authors.initials: J
authors.lastname: Arvidson
authors.forename: O
authors.initials: O
authors.lastname: Ljunggren
authors.forename: J
authors.initials: J
authors.lastname: Gustafsson
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D015519:Bone Density; D002648:Child; D002675:Child, Preschool; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000502:physiology; D050723:Fractures, Bone / Q000209:etiology; D006615:Hip / Q000000981:diagnostic imaging / Q000502:physiology; D019382:Human Growth Hormone / Q000172:deficiency; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000502:physiology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012306:Risk; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D019172:Transplantation Conditioning; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000502:physiology; D014808:Vitamin D Deficiency / Q000000981:diagnostic imaging; D014916:Whole-Body Irradiation / Q000009:adverse effects
chemical_list: D019382:Human Growth Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D