title: Management of meconium aspiration syndrome with highfrequency oscillatory ventilation.
abstract: BACKGROUND
  High-frequency oscillatory ventilation (HFOV) has been advocated for use to improve lung inflation while potentially decreasing lung injury. There were few data on the early use of HFOV in hypoxemic term neonates.
  
  
  OBJECTIVE
  To evaluate the effectiveness of HFOV, used as the initial mode of ventilation, in neonates with severe meconium aspiration syndrome (MAS).
  
  
  METHODS
  In a tertiary care paediatric intensive care unit, 17 term neonates with severe MAS were managed with HFOV, used as the initial mode of ventilation, and prospectively evaluated. Ventilator settings, blood gases, oxygenation index (OI) and alveolar-arterial oxygen difference (P(A-a)O2) were prospectively recorded during HFOV treatment and compared at the multiple time intervals.
  
  
  RESULTS
  Target ventilation was easily achieved with HFOV. Initiation of HFOV caused a significant decrease in FIO2, achieved as early as 1 hour (from 0.93 ± 0.11 to 0.78 ± 0.25; p=0.031) and the improvement was sustained during the 1-32 hours period. There were a significant decreases in P (A-a) O2 and OI, respectively, at 4 hours (from 562.5 ± 71.7 to 355.4 ± 206 mm Hg; p=0.03) and 8 hours (from 23.3±17 to 14.6±16.3; p=0.04), that were sustained up to 16 and 40 hours . Three neonates (17.6%) developed pneumothorax on HFOV. One patient required oxygen support at 28 days. No significant others complications associated with HFOV were detected. Sixteen infants (94 %) were successfully weaned from HFOV and 15 (88%) survived to hospital discharge.
  
  
  CONCLUSIONS
  Use of HFOV as the initial mode of ventilation in neonates with severe MAS is an effective strategy.
authors.affiliation: Childrens's Hospital, Tunis, Tunisia.
authors.forename: Asma
authors.initials: A
authors.lastname: Bouziri
authors.forename: Asma
authors.initials: A
authors.lastname: Hamdi
authors.forename: Ammar
authors.initials: A
authors.lastname: Khaldi
authors.forename: Sarra
authors.initials: S
authors.lastname: Bel Hadj
authors.forename: Khaled
authors.initials: K
authors.lastname: Menif
authors.forename: Nejla
authors.initials: N
authors.lastname: Ben Jaballah
mesh_terms: D005260:Female; D006612:High-Frequency Ventilation; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008471:Meconium Aspiration Syndrome / Q000628:therapy*; D011446:Prospective Studies; D012720:Severity of Illness Index