title: Interventions for wound healing among diabetic patients infected with Staphylococcus aureus: a systematic review.
abstract: OBJECTIVE
  Staphylococcus aureus is the most frequent agent isolated in diabetic foot infections and may be associated with changes to wound healing times. The aim of this study was to perform a systematic review of the literature, including studies that assessed the efficacy of any clinical or surgical intervention, as well as oral or topical therapy for diabetic ulcers infected with S. aureus.
  
  
  METHODS
  Systematic review with a search conducted in databases.
  
  
  METHODS
  We conducted a systematic review with a comprehensive search in the Lilacs, SciELO, PubMed/Medline, Old Medline, Embase and Cochrane Library databases, for articles published from 1966 to 2010. The articles selected were limited to studies on diabetic patients with wounds infected with S. aureus for whom their healing was followed up, with the use of either antibiotics or experimental treatments. Animal studies and those that did not report the wound healing, as well as review articles, were excluded.
  
  
  RESULTS
  Five studies that met the inclusion and exclusion criteria were analyzed.
  
  
  CONCLUSIONS
  There are few studies reporting the healing of wounds infected with S. aureus in diabetic patients, although this is the most commonly found pathogen in this type of wound and it frequently consists of methicillin-resistant S. aureus (MRSA). There is insufficient evidence to support early use of broad-spectrum antibiotics against MRSA to promote healing of diabetic ulcers, since antibiotic resistance may develop from such treatment. This highlights the need for further studies on the subject.
authors.affiliation: Microorganism Physiology and Biochemistry Laboratory, Universidade Federal de Pernambuco, Recife, Brazil. cassialima3@hotmail.com
authors.forename: Anacássia Fonseca
authors.initials: AF
authors.lastname: Lima
authors.forename: Lívia Bandeira
authors.initials: LB
authors.lastname: Costa
authors.forename: Joás Lucas da
authors.initials: JL
authors.lastname: Silva
authors.forename: Maria Bernadete Sousa
authors.initials: MB
authors.lastname: Maia
authors.forename: Eulália Camelo Pessoa Azevedo
authors.initials: EC
authors.lastname: Ximenes
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017719:Diabetic Foot / Q000628:therapy*; D006801:Humans; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus; D013203:Staphylococcal Infections / Q000628:therapy*; D013211:Staphylococcus aureus; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents