title: Catalytic diastereoselective petasis reactions.
abstract: Multicomponent Petasis reactions: the first diastereoselective Petasis reaction catalyzed by chiral biphenols that enables the synthesis of syn and anti β-amino alcohols in pure form has been developed. The reaction exploits a multicomponent approach that involves boronates, α-hydroxy aldehydes, and amines.
authors.affiliation: Broad Institute of Harvard and MIT, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Muncipinto
authors.forename: Philip N
authors.initials: PN
authors.lastname: Moquist
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Schreiber
authors.forename: Scott E
authors.initials: SE
authors.lastname: Schaus
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D000605:Amino Alcohols / Q000138:chemical synthesis / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000588:Amines; D000605:Amino Alcohols; D001713:Biphenyl Compounds; D001897:Boronic Acids; C010574:biphenyl