title: Update of fecal markers of inflammation in inflammatory bowel disease.
abstract: The diagnosis, prognosis, and assessment of disease activity of inflammatory bowel disease (IBD) require investigating clinical, radiological, and histological criteria, as well as serum inflammatory markers. However, a range of fecal inflammatory markers now appears to have the potential to greatly assist in these processes. Calprotectin, a prominent neutrophil protein, was identified two decades ago as a potentially revolutionary marker for IBD. Following this discovery, numerous additional markers, including S100A12, lactoferrin, and M2-pyruvate kinase, have also been suggested as novel markers of IBD. In the present study, we provide an up-to-date review of fecal markers of IBD, and further, provide a novel analysis of each of these fecal markers in severe ulcerative colitis and compare their expression pattern in contrast to calprotectin.
authors.affiliation: School of Women's and Children's Health, University of New South Wales, Australia.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Judd
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Day
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Lemberg
authors.forename: Dan
authors.initials: D
authors.lastname: Turner
authors.forename: Steven T
authors.initials: ST
authors.lastname: Leach
mesh_terms: D015415:Biomarkers / Q000032:analysis; D005243:Feces / Q000737:chemistry; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis*; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000276:immunology; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators