title: Preparation, spectral and biological investigation of formaldehyde-based ligand containing piperazine moiety and its various polymer metal complexes.
abstract: A novel tetradentate salicylic acid-formaldehyde ligand containing piperazine moiety (SFP) was synthesized by condensation of salicylic acid, formaldehyde and piperazine in presence of base catalyst, which was subjected for the preparation of coordination polymers with metal ions like manganese(II), cobalt(II), copper(II), nickel(II) and zinc(II). All the synthesized polymeric compounds were characterized by elemental analysis, IR, (1)H NMR and electronic spectral studies. The thermal stability was determined by thermogravimetric analysis and thermal data revealed that all the polymer metal complexes show good thermal stability than their parent ligand. Electronic spectral data and magnetic moment values revealed that polymer metal complexes of Mn(II), Co(II) and Ni(II) show an octahedral geometry while Cu(II) and Zn(II) show distorted octahedral and tetrahedral geometry respectively. The antimicrobial screening of the ligand and coordination polymers was done by using Agar well diffusion method against various bacteria and fungi. It was evident from the data that antibacterial and antifungal activity increased on chelation and all the polymer metal complexes show excellent antimicrobial activity than their parent ligand.
authors.affiliation: Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India.
authors.forename: Shamim Ahmad
authors.initials: SA
authors.lastname: Khan
authors.forename: Nahid
authors.initials: N
authors.lastname: Nishat
authors.forename: Shadma
authors.initials: S
authors.lastname: Parveen
authors.forename: Raza
authors.initials: R
authors.lastname: Rasool
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry; D005557:Formaldehyde / Q000737:chemistry*; D008024:Ligands; D008345:Manganese / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D009532:Nickel / Q000737:chemistry; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D008024:Ligands; D010879:Piperazines; D011108:Polymers; D012545:Schiff Bases; D005557:Formaldehyde; D000077489:Piperazine; D003035:Cobalt; D008345:Manganese; D003300:Copper; D009532:Nickel