title: Air pollution from traffic and cancer incidence: a Danish cohort study.
abstract: BACKGROUND
  Vehicle engine exhaust includes ultrafine particles with a large surface area and containing absorbed polycyclic aromatic hydrocarbons, transition metals and other substances. Ultrafine particles and soluble chemicals can be transported from the airways to other organs, such as the liver, kidneys, and brain. Our aim was to investigate whether air pollution from traffic is associated with risk for other cancers than lung cancer.
  
  
  METHODS
  We followed up 54,304 participants in the Danish Diet Cancer and Health cohort for 20 selected cancers in the Danish Cancer Registry, from enrolment in 1993-1997 until 2006, and traced their residential addresses from 1971 onwards in the Central Population Registry. We used modeled concentration of nitrogen oxides (NO(x)) and amount of traffic at the residence as indicators of traffic-related air pollution and used Cox models to estimate incidence rate ratios (IRRs) after adjustment for potential confounders.
  
  
  RESULTS
  NO(x) at the residence was significantly associated with risks for cervical cancer (IRR, 2.45; 95% confidence interval [CI], 1.01;5.93, per 100 μg/m(3) NO(x)) and brain cancer (IRR, 2.28; 95% CI, 1.25;4.19, per 100 μg/m(3) NO(x)).
  
  
  CONCLUSIONS
  This hypothesis-generating study indicates that traffic-related air pollution might increase the risks for cervical and brain cancer, which should be tested in future studies.
authors.affiliation: Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dk
authors.forename: Ole
authors.initials: O
authors.lastname: Raaschou-Nielsen
authors.forename: Zorana J
authors.initials: ZJ
authors.lastname: Andersen
authors.forename: Martin
authors.initials: M
authors.lastname: Hvidberg
authors.forename: Steen S
authors.initials: SS
authors.lastname: Jensen
authors.forename: Matthias
authors.initials: M
authors.lastname: Ketzel
authors.forename: Mette
authors.initials: M
authors.lastname: Sørensen
authors.forename: Johnni
authors.initials: J
authors.lastname: Hansen
authors.forename: Steffen
authors.initials: S
authors.lastname: Loft
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
mesh_terms: D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced* / Q000145:classification / Q000453:epidemiology*; D009589:Nitrogen Oxides / Q000032:analysis / Q000633:toxicity*; D012111:Residence Characteristics; D001335:Vehicle Emissions / Q000032:analysis / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D009589:Nitrogen Oxides; D001335:Vehicle Emissions