title: Can alginate-based preloads increase weight loss beyond calorie restriction? A pilot study in obese individuals.
abstract: This randomized, controlled, 2-week intervention study in 24 obese subjects tested the effect on body weight loss and gastrointestinal tolerance of consuming low viscous alginate fibre-based preloads of 3% concentration (500 ml volume) three times a day as an adjuvant to a calorie-restricted diet. The pilot study showed that intake of the alginate preloads was moderately acceptable to the majority of subjects but did not produce additional body weight loss beyond calorie restriction (-1.42 ± 0.38 kg) (n=12) compared to control group (-1.56 ± 0.21 kg) (n=8). These results do not support that alginate supplementation enhance the weight loss effects of a hypo-caloric diet, but a sufficiently powered long-term study is needed to explore whether alginate could be an aid for improving weight loss during caloric-restriction.
authors.affiliation: Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark. mmgj@life.ku.dk
authors.forename: M
authors.initials: M
authors.lastname: Georg Jensen
authors.forename: M
authors.initials: M
authors.lastname: Kristensen
authors.forename: A
authors.initials: A
authors.lastname: Astrup
mesh_terms: D000328:Adult; D000464:Alginates / Q000008:administration & dosage*; D015992:Body Mass Index; D031204:Caloric Restriction; D004038:Diet, Reducing; D004043:Dietary Fiber / Q000008:administration & dosage; D019587:Dietary Supplements; D004311:Double-Blind Method; D002149:Energy Intake; D020723:Glucuronic Acid / Q000008:administration & dosage; D006603:Hexuronic Acids / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy*; D010865:Pilot Projects; D057566:Self Report; D015431:Weight Loss; D055815:Young Adult
chemical_list: D000464:Alginates; D004043:Dietary Fiber; D006603:Hexuronic Acids; D020723:Glucuronic Acid