title: A twice daily posaconazole dosing algorithm for children with chronic granulomatous disease.
abstract: Posaconazole (PSZ) may be an attractive alternative for antifungal prophylaxis in children with chronic granulomatous disease. Experience with PSZ in pediatric patients is limited, and no specific dose recommendations exist. A twice daily dosing algorithm based on allometric scaling (body-weight based) for PSZ results in adequate exposure and appears to be safe in children with chronic granulomatous disease.
authors.affiliation: Departments of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. R.Bruggemann@akf.umcn.nl
authors.forename: Marieke E B
authors.initials: ME
authors.lastname: Welzen
authors.forename: Roger J M
authors.initials: RJ
authors.lastname: Brüggemann
authors.forename: J Merlijn
authors.initials: JM
authors.lastname: Van Den Berg
authors.forename: Heleen W
authors.initials: HW
authors.lastname: Voogt
authors.forename: Jos H
authors.initials: JH
authors.lastname: Gilissen
authors.forename: Dasja
authors.initials: D
authors.lastname: Pajkrt
authors.forename: Nigel
authors.initials: N
authors.lastname: Klein
authors.forename: David M
authors.initials: DM
authors.lastname: Burger
authors.forename: Adilia
authors.initials: A
authors.lastname: Warris
mesh_terms: D000293:Adolescent; D000465:Algorithms; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole