title: [Association between oxidative stress parameters and inflammation markers according to the gravity of the acute coronary syndrome].
abstract: BACKGROUND
  Cardiovascular disease is the consequence of appearance and development of atherosclerosis lesions of associated with a inflammatory complication.
  
  
  OBJECTIVE
  To elucidate a possible association between several inflammation and oxidative stress markers according to the severity of coronary artery disease.
  
  
  METHODS
  This study was carried on 93 coronary subjects with: unstable angina (UA; n=42); stable angina (SA; n=15) and acute myocardial infarction (AMI; n=36) and 140 control subjects to whom lipidic, oxidative and inflammatory parameters were determined.
  
  
  RESULTS
  In addition to a moderate hyperhomocysteinemia observed in the coronary artery disease, a significant higher levels of the oxidized LDL (ox-LDL) were found among these patients (p< 0.001). A positive correlation was found between the markers of the inflammation and the gravity of the acute coronary syndrome. One note a significant increase of the rate of ox-LDL and high sensitive CRP to AMI by reports in UA and SA (p=0.00, and p=0.001 respectively) which is linked to an elevation of the plasmatic concentration of the total homocysteine.
  
  
  CONCLUSIONS
  This study suggests an association between the markers of the inflammation and oxidative parameters in the acute coronary syndrome.
authors.affiliation: Faculte de Medecine de Monastir, Tunisie.
authors.forename: Amel
authors.initials: A
authors.lastname: Nakbi
authors.forename: Nadia
authors.initials: N
authors.lastname: Koubaa
authors.forename: Khaldoun
authors.initials: K
authors.lastname: Ben Hamda
authors.forename: Sonia
authors.initials: S
authors.lastname: Hammami
authors.forename: Nabil
authors.initials: N
authors.lastname: Attia
authors.forename: Radhia
authors.initials: R
authors.lastname: Boumiza
authors.forename: Abdelhedi
authors.initials: A
authors.lastname: Miled
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ben Farhat
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hammami
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications* / Q000378:metabolism*; D000328:Adult; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000209:etiology*; D007249:Inflammation / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012720:Severity of Illness Index