title: Improved performance by replacing iminodiacetic residues with glyceryl residues in symmetrically branched oligoglycerols.
abstract: Synthesis of a symmetrically branched diglycerol (BGL002, involving one iminodiacetic residue) as a G2 dendron, and the tetradecaglycerol (BGL014, involving one iminodiacetic residue) as a G4 dendron, is described. Several members of the BGL family of G2-G4 dendrons were assembled, with G2 bearing four hydroxyl groups at the terminus region, G3 bearing eight, and G4 bearing sixteen. It is noteworthy that triglycerol (BGL003, including no iminodiacetic residue), has a water-solubility ten times higher than BGL002, and the liposome surrounded by BGL014 has a duration period in blood vessel roughly two times longer than the liposome surrounded by dodecaglycerol (BGL012, including three iminodiacetic residues).
authors.affiliation: Department of Pharmaceutical Chemistry, Institute of Health Biosciences, Graduate School of The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan. nem@ph.tokushima-u.ac.jp
authors.forename: Hisao
authors.initials: H
authors.lastname: Nemoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ishihara
authors.forename: Takaaki
authors.initials: T
authors.lastname: Araki
authors.forename: Ayato
authors.initials: A
authors.lastname: Katagiri
authors.forename: Masaki
authors.initials: M
authors.lastname: Kamiya
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Matsushita
authors.forename: Hatsuhiko
authors.initials: H
authors.lastname: Hattori
authors.forename: Yukiteru
authors.initials: Y
authors.lastname: Mimura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tomoda
authors.forename: Motoo
authors.initials: M
authors.lastname: Yamasaki
mesh_terms: D005990:Glycerol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D007098:Imino Acids / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007098:Imino Acids; D005990:Glycerol; C008109:iminodiacetic acid