title: Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs.
authors.affiliation: Université de Strasbourg, F-67400 Illkirch, France.
authors.forename: Esther
authors.initials: E
authors.lastname: Kellenberger
authors.forename: Andreas
authors.initials: A
authors.lastname: Hofmann
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D004364:Pharmaceutical Preparations; D010770:Phosphotransferases / Q000037:antagonists & inhibitors; D010946:Plants, Medicinal / Q000201:enzymology; D011485:Protein Binding / Q000502:physiology; D011487:Protein Conformation; D017510:Protein Folding
chemical_list: D001688:Biological Products; D004791:Enzyme Inhibitors; D005419:Flavonoids; D008024:Ligands; D004364:Pharmaceutical Preparations; D010770:Phosphotransferases