title: Antinociceptive and anti-inflammatory activities of crude extracts of Ipomoea involucrata leaves in mice and rats.
abstract: OBJECTIVE
  To investigate antinociceptive and anti-inflammatory activities of crude extract from Ipomoea involucrata leaves (Convolvulaceae) in mice and rats.
  
  
  METHODS
  The antinociceptive activity was tested using acetic acid-induced abdominal writhing test in mice. The anti-inflammatory activity was evaluated using egg albumin induced oedema of rat paw.
  
  
  RESULTS
  Phytochemical screening showed the presence of alkaloids, flavonoids, saponins, terpenoids and tannin. At the doses of 25-100 mg/kg, Ipomoea involucrata exhibited dose-dependent and significant increase in pain threshold in acetic acid -induced writhing test of mice (P<0.05, student t-test) The administration of Ipomoea involucrata leaf extract (25-100 mg/kg) showed dose-dependent decreases in paw volume of egg albumin induced oedema in rats and a significant higher anti-inflammatory activity compared to the standard control (Aspirin).
  
  
  CONCLUSIONS
  These results support the claims on the traditional use of the of Ipomoea involucrata leaves in the treatment of toothache, rheumatic pains and other inflammatory conditions. Studies on the isolation and structural elucidation of the active principle are still needed being carried out.
authors.affiliation: Department of Pharmacognosy and Phytotherapy, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria. uchefideliaijeoma@yahoo.com
authors.forename: Uche Fidelia
authors.initials: UF
authors.lastname: Ijeoma
authors.forename: Shorinwa Olusayo
authors.initials: SO
authors.lastname: Aderonke
authors.forename: Okorie
authors.initials: O
authors.lastname: Ogbonna
authors.forename: Mgbahurike Amaka
authors.initials: MA
authors.lastname: Augustina
authors.forename: Chijioke-Nwauche
authors.initials: CN
authors.lastname: Ifeyinwa
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000418:Albumins / Q000633:toxicity; D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045424:Complex Mixtures / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced; D027741:Ipomoea / Q000737:chemistry*; D008297:Male; D051379:Mice; D059225:Nociception / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
chemical_list: D000418:Albumins; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D045424:Complex Mixtures; D010936:Plant Extracts; D019342:Acetic Acid