title: Reverse the diastereoselectivity of the Rh(I)-catalyzed Pauson-Khand cycloaddition.
abstract: It is discovered that the diastereoselectivity of the Rh(I)-catalyzed Pauson-Khand cycloaddition of chiral enynes can be reversed to generate the trans diastereomer as the major product in the absence of a chelate phosphine ligand when the substrate contains an appropriate functional group capable of chelate coordination to the Rh(I) center. This expands the application of the Rh(I)-based catalytic processes to prepare both the cis and trans stereoisomers.
authors.affiliation: Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Turlington
authors.forename: Lin
authors.initials: L
authors.lastname: Pu