title: Comparative biology of cAMP-induced germinal vesicle breakdown in marine invertebrate oocytes.
abstract: During maturation, oocytes must undergo a process of nuclear disassembly, or "germinal vesicle breakdown" (GVBD), that is regulated by signaling pathways involving cyclic AMP (cAMP). In vertebrate and starfish oocytes, cAMP elevation typically prevents GVBD. Alternatively, increased concentrations of intra-oocytic cAMP trigger, rather than inhibit, GVBD in several groups of marine invertebrates. To integrate what is known about the stimulation of GVBD by intra-oocytic cAMP, this article reviews published data for ascidian, bivalve, brittle star, jellyfish, and nemertean oocytes. The bulk of the review concentrates on the three most intensively analyzed groups known to display cAMP-induced GVBD-nemerteans, ascidians, and jellyfish. In addition, this synopsis also presents some previously unpublished findings regarding the stimulatory effects of intra-oocytic cAMP on GVBD in jellyfish and the annelid worm Pseudopotamilla occelata. Finally, factors that may account for the currently known distribution of cAMP-induced GVBD across animal groups are discussed.
authors.affiliation: Department of Biology, Miyagi University of Education, Sendai, Miyagi, Japan.
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Deguchi
authors.forename: Noriyo
authors.initials: N
authors.lastname: Takeda
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Stricker
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000187:drug effects / Q000502:physiology; D054239:Blastodisc / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology* / Q000502:physiology; D022162:Cytoplasmic Vesicles / Q000187:drug effects / Q000378:metabolism; D015509:Developmental Biology; D005260:Female; D007448:Invertebrates / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D009865:Oocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010828:Physiology, Comparative
chemical_list: D000242:Cyclic AMP