title: Circulating microRNA-26a: potential predictors and therapeutic targets for non-hypertensive intracerebral hemorrhage.
abstract: The mechanisms of non-hypertensive intracerebral hemorrhages (ICH), which may have different pathologies, mechanisms and genetic background from hypertensive ICH, are not clear. MicroRNAs are a new class of endogenous small RNAs that negatively regulate gene expression at the posttranscriptional level. Previous studies indicate that vascular smooth muscle cell (VSMC) function places important role in non-hypertensive ICH. MiRNA-26a, a pivotal regulator of VSMC function, is one of the cell-free miRNAs that could be detected in healthy humans. Therefore, we get the hypotheses that circulating miR-26a is a potential predictors and therapeutic targets for non-hypertensive ICH.
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, and Peking Union Medical College, Beijing 100853, PR China.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Bai
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Lan
authors.initials: L
authors.lastname: Sun
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.forename: Rutai
authors.initials: R
authors.lastname: Hui
mesh_terms: D002543:Cerebral Hemorrhage / Q000097:blood* / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000097:blood*; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology
chemical_list: D035683:MicroRNAs