title: Olanzapine intoxication-related transient diabetes insipidus.
abstract: Olanzapine is a second-generation atypical antipsychotic agent approved for the treatment of psychotic disorders and mania. The effects of olanzapine intoxication include central nervous system depression, hyperthermia, myosis, tachycardia, and orthostatic hypotension. Heretofore, only one case has been reported to develop polyuria after olanzapine overdose (560 mg). We describe a case that developed diabetes insipidus following massive olanzapine ingestion and returned to normal after desmopressin treatment.
authors.affiliation: Psychiatry Department, Medical Faculty, Bezmialem Vakıf University, Istanbul, Turkey. dremelkocer@yahoo.com
authors.forename: Emel
authors.initials: E
authors.lastname: Koçer
authors.forename: Aytekin
authors.initials: A
authors.lastname: Alçelik
authors.forename: Fatih
authors.initials: F
authors.lastname: Canan
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000506:poisoning*; D001569:Benzodiazepines / Q000506:poisoning*; D003919:Diabetes Insipidus / Q000139:chemically induced*; D062787:Drug Overdose; D006801:Humans; D008297:Male; D000077152:Olanzapine; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine