title: Study of thermo-sensitive in-situ gels for ocular delivery.
abstract: The aim of the present study was the development of thermo-sensitive in-situ gels for in-vitro evaluation of ophthalmic delivery systems of ketorolac tromethamine (KT), based on methylcellulose (MC) in combination with hydroxypropylmethyl cellulose (HPMC). The gel temperature of 1% MC solution was observed at 60°C. It was found that 6% oral rehydration salt without dextrose (ORS) was capable to reduce the gel temperature below physiological temperature. HPMC was added to increase viscosity and drug release time. The results indicated a large increase in viscosity at 37°C with addition of HPMC whch provided sustained release of the drug over a 4h period. From in-vitro release studies, it could be concluded that the developed systems were thus a better alternative to conventional eye drops.
authors.affiliation: Pharmaceutics Research Lab II, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India.
authors.forename: Manas
authors.initials: M
authors.lastname: Bhowmik
authors.forename: Sanchita
authors.initials: S
authors.lastname: Das
authors.forename: Dipankar
authors.initials: D
authors.lastname: Chattopadhyay
authors.forename: Lakshmi K
authors.initials: LK
authors.lastname: Ghosh