title: Development of transient peanut allergy following lung transplantation: a case report.
abstract: A 47-year-old woman underwent bilateral lung transplantation for nonspecific interstitial pneumonitis and received donor lungs from a 12-year-old patient with a known peanut allergy. Post-transplant, the patient experienced four anaphylaxis-like reactions. A skin prick test to peanut was initially positive; however, it steadily declined over serial assessments and reverted to negative one year post-transplant. The patient subsequently had a negative oral peanut challenge. Transfer of food allergy post-transplantation is theorized to occur via transfer of donor B lymphocytes producing peanut-specific immunoglobulin E into the circulation of the recipient. An alternate mechanism proposes passive transfer of immunoglobulin E-sensitized mast cells and⁄or basophils within the transplanted tissue that subsequently migrate into recipient tissues. The gradual decline in the magnitude of the peanut skin prick test and its return to negative over the course of one year supports the gradual depletion of sensitized cells in the recipient (B lymphocytes and, possibly, mast cells), and supports the initial passive transfer of sensitized cells from donor tissue during transplantation. This should be considered when donor organs are obtained from allergic individuals.
authors.affiliation: University Health Network, Toronto Western Hospital, Ontario.
authors.forename: Sacha
authors.initials: S
authors.lastname: Bhinder
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Heffer
authors.forename: Jason K
authors.initials: JK
authors.lastname: Lee
authors.forename: Cecilia
authors.initials: C
authors.lastname: Chaparro
authors.forename: Susan M
authors.initials: SM
authors.lastname: Tarlo
mesh_terms: D000707:Anaphylaxis / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D001402:B-Lymphocytes / Q000473:pathology*; D016923:Cell Death; D002470:Cell Survival; D005260:Female; D006087:Graft vs Host Reaction / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E; D017563:Lung Diseases, Interstitial / Q000601:surgery; D016040:Lung Transplantation / Q000009:adverse effects* / Q000276:immunology / Q000473:pathology; D008407:Mast Cells / Q000473:pathology*; D008875:Middle Aged; D021183:Peanut Hypersensitivity / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D012882:Skin Tests; D020858:Tissue and Organ Harvesting / Q000592:standards
chemical_list: D007073:Immunoglobulin E