title: [Expression of ERK and nm23-H1 in tongue squamous cell carcinoma and its relation with invasion and metastasis].
abstract: OBJECTIVE
  To reveal the relations between expression of extracellular signal-regulated kinase (ERK) and nm23-H1 and tumor invasion and metastasis in tongue squamous cell carcinoma (TSCC).
  
  
  METHODS
  The expression of ERK and nm23-H1 at protein level was examined in 74 cases of TSCC by strep avidin-biotin complex (SABC) immunohistochemical technique. SPSS10.0 software package was used for data analysis.
  
  
  RESULTS
  The expression of ERK was positively related to TNM clinical stage and cervical lymph node metastasis. The expression of nm23-H1 was negatively related to TNM clinical stage and cervical lymph node metastasis. The expression of ERK had a negative correlation with the expression of nm23-H1. TSCC cases with ERK(+)/nm23-H1(-) revealed significant higher tendency to cervical lymph node metastasis than those with ERK(-)/nm23-H1(+).
  
  
  CONCLUSIONS
  The expression of ERK and nm23-H1 is correlated with invasion and cervical lymph node metastasis in TSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China. wangqx@sj-hospial.org
authors.forename: Qiu-xu
authors.initials: QX
authors.lastname: Wang
authors.forename: Tian-xiang
authors.initials: TX
authors.lastname: Wang
authors.forename: Wei-xian
authors.initials: WX
authors.lastname: Liu
mesh_terms: D002294:Carcinoma, Squamous Cell; D048049:Extracellular Signal-Regulated MAP Kinases; D006801:Humans; D008207:Lymphatic Metastasis; D054778:NM23 Nucleoside Diphosphate Kinases; D009361:Neoplasm Invasiveness; D014062:Tongue Neoplasms
chemical_list: D054778:NM23 Nucleoside Diphosphate Kinases; D048049:Extracellular Signal-Regulated MAP Kinases