title: GABA(A) receptor- and GABA transporter polymorphisms and risk for essential tremor.
abstract: BACKGROUND
  Clinical features and animal models of essential tremor (ET) suggest gamma-aminobutyric acid A receptor (GABA(A) R) subunits and GABA transporters as putative candidate genes.
  
  
  METHODS
  A total of 503 ET cases and 818 controls were investigated for an association between polymorphisms in 15 GABA(A) R and four GABA transporter genes and ET.
  
  
  RESULTS
  Nine nominally significant tagging SNPs (P values from 4.9×10(-2) to 5.2×10(-4) ) were found in the hypothesis generation stage. Five SNPs were followed up in a second verification stage but failed to reach significance. (P values from 0.30 to 0.77).
  
  
  CONCLUSIONS
  In our samples, no evidence of association between GABA(A) R and GABA transporter genes with ET was detected. Further studies are necessary to clarify the role of these genes in ET.
authors.affiliation: Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel.
authors.forename: S
authors.initials: S
authors.lastname: Thier
authors.forename: G
authors.initials: G
authors.lastname: Kuhlenbäumer
authors.forename: D
authors.initials: D
authors.lastname: Lorenz
authors.forename: M
authors.initials: M
authors.lastname: Nothnagel
authors.forename: A
authors.initials: A
authors.lastname: Nebel
authors.forename: K
authors.initials: K
authors.lastname: Christensen
authors.forename: S
authors.initials: S
authors.lastname: Schreiber
authors.forename: G
authors.initials: G
authors.lastname: Deuschl
authors.forename: S
authors.initials: S
authors.lastname: Klebe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D020329:Essential Tremor / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D050485:GABA Plasma Membrane Transport Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011963:Receptors, GABA-A / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D050485:GABA Plasma Membrane Transport Proteins; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid