title: Neuraminidase inhibitory terpenes from endophytic Cochliobolus sp.
abstract: The chemical study of endophytic fungus of Cochliobolus led to the isolation of 10 terpenes (1-10), including one new compound named isocochlioquinone B (1). Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 5-7 showed significant neuraminidase inhibitory activity with IC(50) values of 0.79-1.75 μM.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing, China.
authors.forename: Gao-Fei
authors.initials: GF
authors.lastname: Zhang
authors.forename: Zhi-Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Jiang-Tao
authors.initials: JT
authors.lastname: Cui
authors.forename: Ren-Xiang
authors.initials: RX
authors.lastname: Tan
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Ge
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D053139:Oseltamivir / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D016227:Benzoquinones; D013729:Terpenes; C561162:isocochlioquinone B; D053139:Oseltamivir; D009439:Neuraminidase