title: Interleukin-8 gene polymorphism is associated with acute coronary syndrome in the Chinese Han population.
abstract: BACKGROUND
  Acute coronary syndrome (ACS) is one of the most common forms of heart disease. Recent studies have shown that interleukin (IL)-8 plays a key role in the development of atherosclerotic plaques, but the relationship between the common genetic variants of IL-8 and ACS has not been extensively studied.
  
  
  METHODS
  This case-control study in the Chinese Han population included 675 patients with ACS and 636 age- and sex-matched controls. We investigated IL-8 polymorphisms and their association with susceptibility to ACS. The investigation was replicated in the second study comprising 360 cases and 360 control subjects. The plasma concentration of IL-8 was measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  IL-8 -251 A/T polymorphism was associated with increased susceptibility to ACS (P=0.004; odds ratio=1.30; 95% confidence interval: 1.12-1.53). The second study yielded similar results. An increased IL-8 level was found in the plasma of acute myocardial infarction patients, suggesting that IL-8 -251 A/T may affect the expression of IL-8.
  
  
  CONCLUSIONS
  IL-8 -251 A/T polymorphism is associated with ACS risk in the Chinese Han population and the A allele of IL-8 -251 A/T may be an independent predictive factor for ACS.
authors.affiliation: Department of Cardiology, Cardiovascular Research Institute, Northern Hospital, Shenyang 110084, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhang
authors.forename: BaoHai
authors.initials: B
authors.lastname: Zhang
authors.forename: Mingxiang
authors.initials: M
authors.lastname: Zhang
authors.forename: Yaling
authors.initials: Y
authors.lastname: Han
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zimin
authors.initials: Z
authors.lastname: Meng
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Kang
authors.forename: Chenghui
authors.initials: C
authors.lastname: Yan
mesh_terms: D054058:Acute Coronary Syndrome / Q000208:ethnology / Q000235:genetics*; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D017931:DNA Primers; D005006:Ethnicity; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D017931:DNA Primers; D016209:Interleukin-8