title: Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.
abstract: The use of small molecule surrogates of growth factors that directly or indirectly promote growth represents an attractive approach to regenerative medicine. With synthetic access to clovanemagnolol, a small molecule initially isolated from the bark of the Bigleaf Magnolia tree, we have examined the small molecule's ability to promote growth of embryonic hippocampal and cortical neurons in serum-free medium. Comparisons with magnolol, a known promoter of growth, reveals that clovanmagnolol is a potent neurotrophic agent, promoting neuronal growth at concentrations of 10 nM. In addition, both clovanemagnolol and magnolol promote growth through a biphasic dose response.
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78701, United States.
authors.forename: Zin
authors.initials: Z
authors.lastname: Khaing
authors.forename: Danby
authors.initials: D
authors.lastname: Kang
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Camelio
authors.forename: Christine E
authors.initials: CE
authors.lastname: Schmidt
authors.forename: Dionicio
authors.initials: D
authors.lastname: Siegel
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology* / Q000196:embryology; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000166:cytology* / Q000196:embryology; D008968:Molecular Conformation; D008970:Molecular Weight; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D001685:Biological Factors; D010636:Phenols; D012717:Sesquiterpenes; C549996:clovanemagnolol