title: Vertebral growth modulation by hemicircumferential electrocoagulation: an experimental study in pigs.
abstract: BACKGROUND
  This experimental study in pigs was aimed at evaluating spinal growth disorders after partial arrest of the vertebral epiphyseal plates (EP) and neurocentral cartilages (NCC). Unilateral and multisegmental single or combined lesions of the physeal structures were performed by electrocoagulation throughout a video-assisted thoracoscopical approach.
  
  
  METHODS
  Thirty 4-week-old domestic pigs (mean weight 16 kg) were included in the experiments. The superior and inferior epiphyseal plates of T5 to T9 vertebra were damaged in ten animals by hemicircumferential electrocoagulation (group I). In other ten pigs (group II), right NCC at the same T5-T9 levels were damaged. Ten other animals underwent combined lesions of the ipsilateral hemiepiphyseal plates and NCC at the T5-T9 levels. A total of 26 animals could be evaluated after 12 weeks of follow-up using conventional X-rays, CT scans and histology.
  
  
  RESULTS
  The pigs with hemicircumferential EP damage developed very slight concave non-structured scoliotic deformities without vertebral rotation.(mean 12° Cobb; range10-16°). Some of the damaged vertebra showed a marked wedgening with unilateral development alteration of the vertebral body, including the adjacent discs The animals with damage of the NCC developed mild scoliotic curves (mean 19° Cobb; range 16-24°) with convexity opposite to the damaged side and loss of physiological kyphosis. The injured segments showed an asymmetric growth with hypoplasia of the pedicle and costovertebral joints at the damaged side. The pigs undergoing combined EP and NCC lesions developed minimal non-structured curves, ranging from 10 to 12° Cobb. In these animals there was a lack of growth of a vertebral hemibody and disc hypoplasia at the damaged segments. Both damage of the NCC and the EP affect the height of the vertebral body. No spinal stenosis was found in any case. In most cases, the adjacent superior and inferior vertebral EP to damaged segments had a compensatory growth that maintained the straight spinal shape.
  
  
  CONCLUSIONS
  In summary, unilateral direct lesion of the EP by hemicircumferential thoracoscopic electrocoagulation modifies vertebral growth, but is not able to induce true scoliostic curves in pigs. Only animals with damaged NCC developed mild scoliotic curves of lordotic type. This work rediscovers and emphasizes the decisive role of the neurocentral cartilage in the ethiopatogeny of idiopathic scoliosis.
authors.affiliation: Spinal Surgery Unit, Hospital La Fraternidad, Paseo de la Habana 83-85, Madrid, Spain. acaballero68@hotmail.com
authors.forename: Alberto
authors.initials: A
authors.lastname: Caballero
authors.forename: Carlos
authors.initials: C
authors.lastname: Barrios
authors.forename: Jesús
authors.initials: J
authors.lastname: Burgos
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hevia
authors.forename: Carlos
authors.initials: C
authors.lastname: Correa
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000293:injuries / Q000473:pathology; D004195:Disease Models, Animal; D004564:Electrocoagulation / Q000009:adverse effects / Q000379:methods*; D006132:Growth Plate / Q000000981:diagnostic imaging / Q000473:pathology; D008141:Lordosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D011859:Radiography; D000072042:Salter-Harris Fractures; D012600:Scoliosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D034421:Sus scrofa; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000254:growth & development* / Q000473:pathology*