title: Effects of genetic polymorphism and enzyme induction in the glutathione S-transferase family on chemical safety and risk assessment.
abstract: Glutathione is important in the detoxication of many xenobiotic chemicals and in the bioactivation of some. The glutathione-S-transferases are a super-family of enzymes involved in conjugation of xenobiotics with glutathione. There are wide genetically determined inter-individual differences in the expression of the isoenzymes. These differences may have important implications for the toxicity of compounds such as polycyclic aromatic hydrocarbons and aflatoxins.
authors.forename: B
authors.initials: B
authors.lastname: Ketterer