title: [Effects of glycyrrhiza extract on pharmacokinetics property of daphnetin in rats].
abstract: OBJECTIVE
  To research the influence of glycyrrhiza extract on the pharmacokinetics characteristic parameters of daphnetin, which was aimed to explore the rationality of concert application of drugs.
  
  
  METHODS
  The rats received intragastric administration of daphnetin and glycyrrhiza extract containing the same daphnetin respectively. The blood concentration of daphnetin was assayed by LC-MS. The data was processed by program DAS2.1.1.
  
  
  RESULTS
  Glycyrrhiza extract can reduce the t(1/2), tmax and Ke of daphnetin, while increased the Ka and AUC(0-infinity).
  
  
  CONCLUSIONS
  Glycyrrhiza extract promoted the oral absorption of daphnetin, slowed down the elimination and increased the biological availability.
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors.forename: Letian
authors.initials: L
authors.lastname: Chen
authors.forename: Liuqing
authors.initials: L
authors.lastname: Di
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Jinjun
authors.initials: J
authors.lastname: Shan
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Baochang
authors.initials: B
authors.lastname: Cai
mesh_terms: D000818:Animals; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution / Q000187:drug effects; D014468:Umbelliferones / Q000493:pharmacokinetics*
chemical_list: D004365:Drugs, Chinese Herbal; D014468:Umbelliferones; C039952:daphnetin