title: Coffee consumption and cystatin-C-based estimated glomerular filtration rates in healthy young adults: results of a clinical trial.
abstract: Recently it has been reported that the estimated glomerular filtration rate (eGFR) is higher in habitual coffee consumers than in noncoffee consumers. However, the causality remains unclear. Therefore, we conducted a clinical trial to investigate the effects of coffee consumption on kidney function. Nineteen asymptomatic nonsmokers aged 21-27 years old participated in this study. They consumed coffee (18 g coffee beans/450 mL per day) or green tea as a comparator for 2 weeks in a crossover design. Although creatinine-based eGFR was not affected after consuming either beverage, all cystatin-C-based eGFRs determined using five different equations were significantly increased after coffee consumption (means: 5.0-7.7%), but not after green tea consumption (means: 0.1-1.6%). Serum adiponectin and magnesium levels increased significantly after coffee consumption (means: 13.6% and 4.3%, resp.), but not after green tea consumption. These findings suggest that even a short period of coffee consumption may increase cystatin-C-based eGFR, along with favorable changes in serum adiponectin, in healthy young adults.
authors.affiliation: Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Saito
authors.forename: Tohru
authors.initials: T
authors.lastname: Nemoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tobimatsu
authors.forename: Midori
authors.initials: M
authors.lastname: Ebata
authors.forename: Yulan
authors.initials: Y
authors.lastname: Le
authors.forename: Kei
authors.initials: K
authors.lastname: Nakajima