title: Synthesis, single-crystal characterization, antimicrobial activity and remarkable in vitro DNA interaction of hydrogen-bonded proton-transfer complex of 1,10-phenanthroline with 2,4,6-trinitrophenol.
abstract: A new charge transfer complex as a result of interaction between 1,10-phenanthroline (donor) with 2,4,6-trinitrophenol (picric acid), acceptor, was synthesized and characterized by FTIR, (1)H NMR, (13)C NMR, mass spectroscopy, single-crystal X-ray diffraction and elemental analysis. The single crystal structure indicates that the cation and anion are joined together by strong N(+)H⋯O(-) type hydrogen bonds. This has been attributed to the formation of 1:1 CT complex via hydrogen bonding interaction. The binding of CT complex with in vitro calf thymus DNA was investigated by the fluorescence spectroscopy. To determine the DNA binding ability of the compound, fluorescence intensity data were analyzed by the Stern-Volmer equation and remarkable DNA interaction with CT complex is found. The CT complex was also screened for its antimicrobial activity. The CT complex exhibited inhibitory results against E. coli and Pseudomonas arenginosa, and the marked enhancement in the potency as antifungal agent.
authors.affiliation: Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh 202 002, India. drishaatamu@gmail.com
authors.forename: Ishaat M
authors.initials: IM
authors.lastname: Khan
authors.forename: Afaq
authors.initials: A
authors.lastname: Ahmad
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aatif
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D006860:Hydrogen Bonding; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010618:Phenanthrolines / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry*; D011522:Protons; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010618:Phenanthrolines; D010851:Picrates; D011522:Protons; D004247:DNA; C427203:calf thymus DNA; C005858:picric acid; C025205:1,10-phenanthroline