title: Frontline extended surgery is associated with improved survival in retroperitoneal low- to intermediate-grade soft tissue sarcomas.
abstract: BACKGROUND
  The purpose of the study was to retrospectively reassess in our institutional series at a longer follow-up the value of a systematic attempt to carry out wide resections in retroperitoneal soft tissue sarcoma.
  
  
  METHODS
  Three hundred and thirty-one consecutive patients surgically treated were analyzed. Since a shift toward a systematic more extended surgical approach took place starting from 2002, patients were divided in two groups according to the time of surgery. Overall survival (OS), crude cumulative incidence of local recurrence (LR) and distant metastases (DMs) were estimated. Cox model multivariate analysis was carried out.
  
  
  RESULTS
  Five-year OS of patients operated in the recent period was 66%, compared with 48% for those operated in the previous period. This was associated with less LR (28% versus 49%), while the number of DMs was higher in the recent group (25% versus 12%). Beside the treatment period, the only independent determinant for survival was histological grade.
  
  
  CONCLUSIONS
  The adoption of a policy of more liberal visceral en bloc resections was associated with a higher local control and OS. This benefit was evident in patients with grade I-II tumors, while DMs were a limiting factor in high-grade ones. New therapies are needed to control systemic disease as local surgery may improve local control.
authors.affiliation: Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. alessandro.gronchi@istitutotumori.mi.it
authors.forename: A
authors.initials: A
authors.lastname: Gronchi
authors.forename: R
authors.initials: R
authors.lastname: Miceli
authors.forename: C
authors.initials: C
authors.lastname: Colombo
authors.forename: S
authors.initials: S
authors.lastname: Stacchiotti
authors.forename: P
authors.initials: P
authors.lastname: Collini
authors.forename: L
authors.initials: L
authors.lastname: Mariani
authors.forename: C
authors.initials: C
authors.lastname: Sangalli
authors.forename: S
authors.initials: S
authors.lastname: Radaelli
authors.forename: R
authors.initials: R
authors.lastname: Sanfilippo
authors.forename: M
authors.initials: M
authors.lastname: Fiore
authors.forename: P G
authors.initials: PG
authors.lastname: Casali
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D016016:Proportional Hazards Models; D012186:Retroperitoneal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*