title: [Doctor initiated clinical trial for obtaining evidences in treatment of osteoporosis: JOINT (Japanese Osteoporosis Intervention Trial) protocol].
abstract: Due to the recent advances in the treatment of osteoporosis, clinicians can utilize many kinds of drugs to prevent fractures. Evidence of drug supplied to clinicians was mainly obtained from the results of the developmental studies. However, the evidence is still lack for the treatment in an individual patient in the"real world". This is a reason why we build up A-TOP (Adequate Treatment of Osteoporosis) research group and why we perform JOINT (Japanese Osteoporosis Intervention Trial) protocol to obtain the evidences, which are required by the clinicians. The two protocols were aimed to investigate whether concurrent treatment with bisphosphonates and active vitamin D3 (JOINT02) or vitamin K2 (JOINT03) is effective or not comparing to the mono-therapy. The former project was finished the 2-year observation and the latter project is currently underwent. The present paper introduces the aims, rationale, and organization of JOINT studies.
authors.affiliation: Research Institute and Practice for Involutional Diseases.
authors.forename: Masataka
authors.initials: M
authors.lastname: Shiraki
mesh_terms: D002762:Cholecalciferol / Q000008:administration & dosage*; D004164:Diphosphonates / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D019317:Evidence-Based Medicine; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy*; D024482:Vitamin K 2 / Q000008:administration & dosage*
chemical_list: D004164:Diphosphonates; D024482:Vitamin K 2; D002762:Cholecalciferol