title: Native and fluorescent dye-dependent single-DNA molecule microchip dynamics as measured by differential interference contrast microscopy.
abstract: In a free solution of 10.0 mM Gly-Gly (pH 8.2), the flow directions of native-DNA and DNA molecules intercalated with the fluorescent dye YOYO-1 were reversed in the microchip channel. These results clearly showed that in a confined space and under specific environmental conditions, the fluorescent dye modified the original properties and behavior of the native-DNA molecule.
authors.affiliation: Department of Chemistry, Chonbuk National University, Jeonju 561-756, South Korea.
authors.forename: Doori
authors.initials: D
authors.lastname: Oh
authors.forename: Seungah
authors.initials: S
authors.lastname: Lee
authors.forename: Seong Ho
authors.initials: SH
authors.lastname: Kang
mesh_terms: D001583:Benzoxazoles / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004867:Equipment Design; D005456:Fluorescent Dyes / Q000737:chemistry*; D006033:Glycylglycine / Q000737:chemistry; D007364:Intercalating Agents / Q000737:chemistry*; D008857:Microscopy, Interference / Q000295:instrumentation*; D020411:Oligonucleotide Array Sequence Analysis; D011806:Quinolinium Compounds / Q000737:chemistry*
chemical_list: D001583:Benzoxazoles; D005456:Fluorescent Dyes; D007364:Intercalating Agents; D011806:Quinolinium Compounds; D006033:Glycylglycine; C075296:1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium; D004247:DNA