title: [Clinical application of heterogeneous acellular dermal matrix in the surgical treatment of oral submucous fibrosis].
abstract: OBJECTIVE
  The aim of this study was to evaluate the clinical effect of heterogeneous acellular dermal matrix in the surgical treatment of advanced oral submucous fibrosis (OSF).
  
  
  METHODS
  There were eight patients who had undergone surgical treatment of trismus caused by OSF. Surgery was performed under general anaesthesia given through a nasoendotracheal tube using a fibreoptic bronchoscope. All the fibrous bands on the buccal mucosa were incised and bluntly dissected to stretch the mouth opening. Based on the defect, heterogeneous acellular dermal matrix graft was applied directly on the bilateral wounds. A tie-over dressing technique was used to hold the graft firmly to its bed.The sutures and dressing material were removed on the tenth to fourteenth day after the operation. All the patients were asked to stretch the mouth opening 3 times daily and were followed up for at least 6 months. A modality of medical treatment including multiple micronutrient supplements and steroid injection therapy were carried out if necessary. The changes in the interincisal distances (IDs) were analyzed in the preoperative, intraoperative, and postoperative stages. The data was analyzed with SPSS16.0 software package for one-way ANOVA.
  
  
  RESULTS
  The overall success rate was 100% without any or only partial graft loss. There were no immunologic reactions or significant complications.The mean preoperative, intraoperative, and final follow-up interincisal distances were 12.04, 35.46, and 29.33 mm, respectively. Evaluation of the changes in the IDs revealed statistically significant differences between the values recorded at the different stages.(P<0.05).
  
  
  CONCLUSIONS
  Heterogeneous acellular dermal matrix may be a valuable biomaterial for repairing oral mucosal defects after surgery on the fibrous bands in patients with advanced OSF through covering and protecting wound surface early,which shortens the healing time of wound, decreases relapse of fibrosis and improve the restricted mouth opening.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University. Changsha 410078 , Hunan Province, China. canhuaj@yahoo.com.cn
authors.forename: Can-hua
authors.initials: CH
authors.lastname: Jiang
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Fang-qiong
authors.initials: FQ
authors.lastname: Shi
authors.forename: Xin-qun
authors.initials: XQ
authors.lastname: Chen
authors.forename: Zhan-gui
authors.initials: ZG
authors.lastname: Tang
authors.forename: Xin-chun
authors.initials: XC
authors.lastname: Jian
mesh_terms: D062088:Acellular Dermis; D005355:Fibrosis; D006801:Humans; D009055:Mouth / Q000503:physiopathology; D009061:Mouth Mucosa; D009914:Oral Submucous Fibrosis; D014945:Wound Healing