title: Bringing immunoglobulin knowledge up to date: how should we treat today?
abstract: Immunoglobulin (Ig) therapy is constantly evolving. Advances in the basic and clinical science of immunoglobulins have provided new perspectives in using polyclonal IgG to treat patients with primary immunodeficiencies. Recent meta-analyses of patient data and outcomes, optimization of IgG administration and better understanding of the IgG receptor variability and clinical effect are new concepts which practising immunologists can use in tailoring their approach to treating patients with primary immunodeficiencies. This manuscript presents the proceedings of a satellite symposium, held in conjunction with the European Society for Immunodeficiencies (ESID) 2010 meeting, to inform attendees about new scientific concepts in IgG therapy, with the goal of empowering expert level evaluation of what optimal IgG therapy is today.
authors.affiliation: John Radcliffe Hospital, Oxford, UK Emma Children's Hospital, Amsterdam, the Netherlands Royal Free Hospital and University College London, London, UK. siraj.misbah@orh.nhs.uk
authors.forename: S
authors.initials: S
authors.lastname: Misbah
authors.forename: T
authors.initials: T
authors.lastname: Kuijpers
authors.forename: J
authors.initials: J
authors.lastname: van der Heijden
authors.forename: B
authors.initials: B
authors.lastname: Grimbacher
authors.forename: D
authors.initials: D
authors.lastname: Guzman
authors.forename: J
authors.initials: J
authors.lastname: Orange
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis / Q000096:biosynthesis; D003226:Congresses as Topic; D006801:Humans; D007116:Immunization, Passive / Q000379:methods* / Q000639:trends; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000627:therapeutic use; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000473:pathology; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D015201:Meta-Analysis as Topic; D017452:Receptors, IgG / Q000037:antagonists & inhibitors / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D017452:Receptors, IgG; D002097:C-Reactive Protein