title: Induced pluripotent stem cell technology for generating photoreceptors.
abstract: The discovery of methods to produce pluripotent stem cells from human skin cells and other adult tissues has created a new era in stem cell research. In this article, we discuss the generation and use of pluripotent stem cells for the study of retinal disorders and the development of cell-based therapies. We describe advances in protocols for differentiating pluripotent cells into photoreceptor precursors that might be suitable for transplantation and discuss the use of human induced pluripotent stem cell-derived photoreceptors for disease modeling and drug screening.
authors.affiliation: Department of Genetics, UCL Institute of Ophthalmology 11-43 Bath Street, London EC1V 9EL, UK.
authors.forename: Cédric
authors.initials: C
authors.lastname: Boucherie
authors.forename: Jane C
authors.initials: JC
authors.lastname: Sowden
authors.forename: Robin R
authors.initials: RR
authors.lastname: Ali
mesh_terms: D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology / Q000637:transplantation*; D012162:Retinal Degeneration / Q000473:pathology / Q000628:therapy; D057905:Stem Cell Research; D033581:Stem Cell Transplantation