title: A microfabricated silicon platform with 60 microfluidic chips for rapid mass spectrometric analysis.
abstract: This work presents a way of using silicon microfabrication to take advantage of the rim of a silicon wafer in a novel manner. Our circular multichip platform, which is fabricated using only standard microfabrication techniques, has 60 identical miniaturized micropillar array electrospray ionization (μPESI) chips at the periphery of a silicon wafer. The fabricated platform is fixed on a computer controlled rotating table, in front of a mass spectrometer (MS). After each MS measurement an unused μPESI chip is aligned towards the MS by the programmable rotating table. Our wafer-scale platform enabled measurement of 60 samples in 8 minutes. The samples can also be stored on the platform for later analysis.
authors.affiliation: Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 Helsinki, Finland. lauri.sainiemi@helsinki.fi
authors.forename: Lauri
authors.initials: L
authors.lastname: Sainiemi
authors.forename: Teemu
authors.initials: T
authors.lastname: Nissilä
authors.forename: Risto
authors.initials: R
authors.lastname: Kostiainen
authors.forename: Raimo A
authors.initials: RA
authors.lastname: Ketola
authors.forename: Sami
authors.initials: S
authors.lastname: Franssila
mesh_terms: D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D008904:Miniaturization; D012825:Silicon / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation* / Q000379:methods
chemical_list: D012825:Silicon