title: Impaired early visual response modulations to spatial information in chronic schizophrenia.
abstract: Early visual processing stages have been demonstrated to be impaired in schizophrenia patients and their first-degree relatives. The amplitude and topography of the P1 component of the visual evoked potential (VEP) are both affected; the latter of which indicates alterations in active brain networks between populations. At least two issues remain unresolved. First, the specificity of this deficit (and suitability as an endophenotype) has yet to be established, with evidence for impaired P1 responses in other clinical populations. Second, it remains unknown whether schizophrenia patients exhibit intact functional modulation of the P1 VEP component; an aspect that may assist in distinguishing effects specific to schizophrenia. We applied electrical neuroimaging analyses to VEPs from chronic schizophrenia patients and healthy controls in response to variation in the parafoveal spatial extent of stimuli. Healthy controls demonstrated robust modulation of the VEP strength and topography as a function of the spatial extent of stimuli during the P1 component. By contrast, no such modulations were evident at early latencies in the responses from patients with schizophrenia. Source estimations localized these deficits to the left precuneus and medial inferior parietal cortex. These findings provide insights on potential underlying low-level impairments in schizophrenia.
authors.affiliation: Department of Clinical Neurosciences, University of Lausanne, Switzerland.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Knebel
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Javitt
authors.forename: Micah M
authors.initials: MM
authors.lastname: Murray
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002908:Chronic Disease; D004569:Electroencephalography / Q000379:methods; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010775:Photic Stimulation / Q000379:methods; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000150:complications*; D013028:Space Perception / Q000502:physiology*; D013997:Time Factors; D014786:Vision Disorders / Q000209:etiology* / Q000473:pathology; D055815:Young Adult