title: Spray formulation of silver and hyaluronic acid in the treatment of superficial cutaneous ulcers of different etiopathogenesis: analysis of fifty-four clinical cases.
abstract: OBJECTIVE
  The aim of this study was to assess a spray formulation containing colloidal silver and hyaluronic acid.
  
  
  METHODS
  Patients included in the study were divided in two separate groups: 30 patients had chronic wounds and 24 patients had superficial traumatic wounds. Applications were performed at intervals of 3-7 days, depending upon lesions characteristics. Subsequent improvements were evaluated at various intervals after enrollment. The lesion area and the rate of re-epithelialization were calculated, considering the time span and monitoring the patients for clinical signs of wound infection. Patients satisfaction and compliance were evaluated by a questionnaire aimed at assessing pain and ease of use of the device.
  
  
  RESULTS
  Chronic lesions were healed at week 12, with a high rate of closure observed at 6 weeks (70%). Furthermore, traumatic wounds healed at six weeks, with a substantial percentage of closure (80%) at three weeks. A good control of microbial contamination was evident in all the treated wounds; in no case other antimicrobial medications were used. Finally, patients favorably expressed compliance with regard to the spray formulation and ease of use.
  
  
  CONCLUSIONS
  This type of clinical approach seems to be a rational good choice to promote re-epithelialization of superficial cutaneous ulcers of different origins as well as control of bacterial infections.
authors.affiliation: Department of General Surgery, Center of Diagnosis and Treatment of Vascular Ulcers, Villa Fiorita Clinic, Prato, Italy. lucagazzabin@hotmail.com
authors.forename: L
authors.initials: L
authors.lastname: Gazzabin
authors.forename: M
authors.initials: M
authors.lastname: Bucalossi
authors.forename: F
authors.initials: F
authors.lastname: Mariani
authors.forename: S
authors.initials: S
authors.lastname: Serantoni
mesh_terms: D000287:Administration, Topical; D000368:Aged; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012834:Silver / Q000008:administration & dosage*; D012883:Skin Ulcer / Q000188:drug therapy* / Q000209:etiology
chemical_list: D012834:Silver; D006820:Hyaluronic Acid