title: Influence of a dose-dense adjuvant chemotherapy on sVCAM-1/sICAM-1 serum levels in breast cancer patients with 1-3 positive lymph nodes.
abstract: OBJECTIVE
  The aim of the present study was to investigate the effects of conventional and dose-dense chemotherapy on serum levels of soluble adhesion molecules sICAM-1 and sVCAM-1 in node-positive patients with breast cancer.
  
  
  METHODS
  sICAM-1 and sVCAM-1 were measured in the blood serum of 147 patients with breast cancer and with 1 to 3 affected lymph nodes prior to and after conventional or dose-dense chemotherapy within a randomized phase III study (NOGGO trial).
  
  
  RESULTS
  The increase in sICAM-1 (p<0.0001) and sVCAM-1 (p<0.001) levels after chemotherapy was statistically significant within the entire sample and the dose-dense study arm. sVCAM-1 levels were not altered by conventional chemotherapy, but were markedly and significantly increased after the dose-dense regimen. Higher sICAM-1 concentrations were found in postmenopausal patients, and the difference was significant before, but not after treatment. There was no significant correlation with other prognostic criteria.
  
  
  CONCLUSIONS
  Both sVCAM-1 and sICAM-1 levels changed significantly after adjuvant chemotherapy, the effect being more marked under the dose-dense regimen. The possible prognostic relevance of adhesion molecule concentration and the effect of different modes of chemotherapy remains to be determined.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Magdeburg, Magdeburg, Germany.
authors.forename: Holm
authors.initials: H
authors.lastname: Eggeman
authors.forename: Frank
authors.initials: F
authors.lastname: Stöblen
authors.forename: Marc
authors.initials: M
authors.lastname: Thill
authors.forename: Susanne
authors.initials: S
authors.lastname: Korlach
authors.forename: Peter
authors.initials: P
authors.lastname: Schmid
authors.forename: Diana
authors.initials: D
authors.lastname: Lüftner
authors.forename: Dirk
authors.initials: D
authors.lastname: Elling
authors.forename: Florin-Andrei
authors.initials: FA
authors.lastname: Taran
authors.forename: Sherko
authors.initials: S
authors.lastname: Kümmel
authors.forename: Solveig
authors.initials: S
authors.lastname: Landt
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D000970:Antineoplastic Agents; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1