title: Gene delivery in salivary glands: from the bench to the clinic.
abstract: In vivo gene delivery has long been seen as providing opportunities for the development of novel treatments for disorders refractory to existing therapies. Over the last two decades, salivary glands have proven to be a useful, if somewhat unconventional, target tissue for studying several potential clinical applications of therapeutic gene delivery. Herein, we follow the progress, address some problems and assess the outlook for clinical applications of salivary gland gene delivery. Our experience with these tissues provides a roadmap for the process of moving an idea from the laboratory bench to patients.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Barzilai Medical Center, Ashkelon, Israel.
authors.forename: Yuval
authors.initials: Y
authors.lastname: Samuni
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Baum
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000008:administration & dosage*; D006801:Humans; D011832:Radiation Injuries / Q000235:genetics / Q000628:therapy*; D012469:Salivary Glands / Q000378:metabolism*