title: Organization of SNAREs within the Golgi stack.
abstract: Antero- and retrograde cargo transport through the Golgi requires a series of membrane fusion events. Fusion occurs at the cis- and trans-side and along the rims of the Golgi stack. Four functional SNARE complexes have been identified mediating lipid bilayer merger in the Golgi. Their function is tightly controlled by a series of reactions involving vesicle tethering and SM proteins. This network of protein interactions spatially and temporally determines the specificity of transport vesicle targeting and fusion within the Golgi.
authors.affiliation: Heidelberg University Biochemistry Center, 69120 Heidelberg, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Malsam
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Söllner
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001692:Biological Transport; D006056:Golgi Apparatus / Q000378:metabolism*; D008954:Models, Biological; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D050600:SNARE Proteins / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D016415:Sequence Alignment; D022161:Transport Vesicles / Q000378:metabolism / Q000502:physiology
chemical_list: D050600:SNARE Proteins