title: Proteinuria in an African HIV-infected patient: effects of telmisartan.
abstract: Kidney disease remains a major comorbidity of HIV infection especially in subjects of African ethnicity. HIV-associated renal disease with overt proteinuria has been associated with poorer outcomes and increased mortality. Telmisartan, an angiotensin II receptor blocker partial agonist of the PPAR-? approved for the treatment of hypertension, seems to exert a nephro-protective effect independent of blood pressure reduction in the general population. But data are lacking in HIV-positive patients with proteinuria. A case is described of an HIV-positive African patient with severe proteinuria treated with telmisartan. This therapy allowed proteinuria to be improved. This case shows for the first time that therapy with telmisartan has renoprotective effects also in an African HIV-infected patient.
authors.affiliation: Infectious Disease Clinic, Department of Medicine and Science of Aging G. d'Annunzio University, School of Medicine, Chieti, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Ucciferri
authors.forename: K
authors.initials: K
authors.lastname: Falasca
authors.forename: P
authors.initials: P
authors.lastname: Mancino
authors.forename: E
authors.initials: E
authors.lastname: Pizzigallo
authors.forename: J
authors.initials: J
authors.lastname: Vecchiet
mesh_terms: D000349:Africa / Q000208:ethnology; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D001565:Benzoates / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000188:drug therapy* / Q000209:etiology; D000077333:Telmisartan
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D000077333:Telmisartan