title: δ-Aminolevulinate dehydratase activity in type 2 diabetic patients and its association with lipid profile and oxidative stress.
abstract: OBJECTIVE
  To investigate the activity of δ-Aminolevulinate dehydratase (δ-ALA-D) and its possible relationship with oxidative status, lipid profile, body mass index (BMI) in type 2 diabetics (DM2) patients.
  
  
  METHODS
  δ-ALA-D activity and reactivation index, as well as markers of oxidative stress and biochemical and anthropometrics parameters were determined in DM2 patients (n = 63) and controls (n = 63).
  
  
  RESULTS
  There was a decreased δ-ALA-D activity and a higher reactivation index (p<0.05) in DM2 patients besides an elevated level of oxidative stress. Disturbances on lipid profile were related to the enzymatic activity and BMI also was correlated with oxidative level in DM2 patients (p<0.05).
  
  
  CONCLUSIONS
  There is an association between oxidative stress, abnormalities on lipid profile, distribution of body fat and δ-ALA-D activity inhibition as well as the enzyme is more oxidized in the DM2 suggesting that it would be a good biomarker for assessing prejudice in chronic metabolic processes.
authors.affiliation: Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil. Electronic address: gabriela_bonfanti@yahoo.com.br.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Bonfanti
authors.affiliation: Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil. Electronic address: roniceolin@yahoo.com.br.
authors.forename: Ronise B
authors.initials: RB
authors.lastname: Ceolin
authors.affiliation: Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil. Electronic address: tvalcorte@yahoo.com.br.
authors.forename: Tiago
authors.initials: T
authors.lastname: Valcorte
authors.affiliation: Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil. Electronic address: ksbona@yahoo.com.br.
authors.forename: Karine S
authors.initials: KS
authors.lastname: De Bona
authors.affiliation: Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil. Electronic address: leidi_lucca@hotmail.com.
authors.forename: Leidiane
authors.initials: L
authors.lastname: de Lucca
authors.affiliation: Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil. Electronic address: thissianegoncalves@yahoo.com.br.
authors.forename: Thissiane L
authors.initials: TL
authors.lastname: Gonçalves
authors.affiliation: Postgraduate Program in Pharmacology, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil. Electronic address: beatriz.moretto@yahoo.com.br.
authors.forename: Maria Beatriz
authors.initials: MB
authors.lastname: Moretto
mesh_terms: D015415:Biomarkers; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D000623:Porphobilinogen Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D008055:Lipids; D000623:Porphobilinogen Synthase