title: ABO-incompatible kidney transplantation in children.
abstract: We designed a new protocol to enable safe ABO-incompatible kidney transplantation. The new protocol utilizes antigen-specific immunoadsorption rather than unspecific plasma exchange to remove existing anti A/B antibodies and rituximab rather than splenectomy to prevent rebound of antibodies. Sixty patients have so far been successfully transplanted with this protocol and 10 of those have been children. When compared with ABO-compatible transplantations, we could not find any differences in success rate, renal function, or adverse events.
authors.affiliation: Departments of Transplantation Surgery Transfusion Medicine Pediatrics, Karolinska University Hospital, Stockholm, Sweden. gunnar.tyden@karolinska.se
authors.forename: Gunnar
authors.initials: G
authors.lastname: Tydén
authors.forename: Gunilla
authors.initials: G
authors.lastname: Kumlien
authors.forename: Ulla B
authors.initials: UB
authors.lastname: Berg
mesh_terms: D000017:ABO Blood-Group System; D000293:Adolescent; D000327:Adsorption; D001787:Blood Group Incompatibility; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000017:ABO Blood-Group System; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents