title: Experimental and theoretical study of the interaction of 3-carboxy-5,6-benzocoumarin with some 1,2,3,4,5,6,7,8-octahydroacridines and the corresponding N-oxides.
abstract: The interaction of 3-carboxy-5,6-benzocoumarin (BzCum) with 1,2,3,4,5,6,7,8-octahydroacridine (OHA), 9-amino-1,2,3,4,5,6,7,8-octahydroacridine (H(2)N-OHA) and the corresponding N-oxides (OHA-NO and H(2)N-OHA-NO) was studied by fluorescence (steady state, time resolved) and absorption spectroscopy. The analysis of the fluorescence data in terms of Stern-Volmer plots indicated a predominant dynamic quenching for OHA and OHA-NO, and a more complex process for H(2)N-OHA and H(2)N-OHA-NO. The dynamic process was assigned to a photoinduced electron transfer (PET) from the acridine derivatives to the excited state of BzCum. The application of the Rehm-Weller-Marcus theory leads to a good agreement with literature data and allows for the estimation of the solvent organization energy. The presence of the PET mechanism was also supported by DFT results. The absorption spectra evidence the formation of a ground state complex assigned to a hydrogen bond complex involving the carboxylic hydrogen of BzCum.
authors.affiliation: University of Bucharest, Faculty of Chemistry, Department of Organic Chemistry, Bd. Panduri 90-92, Bucharest, Romania.
authors.forename: Maria
authors.initials: M
authors.lastname: Marinescu
authors.forename: Cristina
authors.initials: C
authors.lastname: Tablet
authors.forename: Francisc
authors.initials: F
authors.lastname: Potmischil
authors.forename: Mihaela
authors.initials: M
authors.lastname: Hillebrand
mesh_terms: D000042:Absorption; D000166:Acridines / Q000737:chemistry* / Q000494:pharmacology*; D056246:Chemistry, Analytic; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D003497:Cyclic N-Oxides / Q000737:chemistry* / Q000494:pharmacology*; D004347:Drug Interactions; D006860:Hydrogen Bonding; D008954:Models, Biological; D008958:Models, Molecular; D008962:Models, Theoretical; D015394:Molecular Structure; D013057:Spectrum Analysis / Q000379:methods
chemical_list: C429843:1,2,3,4,5,6,7,8-octahydroacridine; C531987:3-carboxy-5,6-benzocoumarinic acid; D000166:Acridines; D003374:Coumarins; D003497:Cyclic N-Oxides