title: [Serum levels of 25-(OH)D(3) and total IgE in children with asthma].
abstract: OBJECTIVE
  To study the changes and clinical significance of serum levels of 25-(OH)D(3) and total IgE in children with asthma.
  
  
  METHODS
  Thirty children with asthma, 40 children with asthmatic bronchitis, and 40 healthy children were enrolled. Double-antibody radioimmunoassay was used to detect the levels of serum 25-(OH)D(3) and total IgE.
  
  
  RESULTS
  Serum 25-(OH)D(3) levels (18±3 ng/Ml)decreased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (43±3 ng/mL) and the control group (43±3 ng/mL) (P<0.01). In contrast, serum total IgE levels (192±16 IU/mL) increased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (123±14 IU/mL) and the control group (118±15 IU/mL) (P<0.01). Serum 25-(OH)D(3) levels were negatively correlated with serum total IgE levels in asthmatic children (r=-0.783, P<0.01). There were no correlation between serum 25-(OH)D(3) levels and serum total IgE level in the asthmatic bronchitis and the control groups.
  
  
  CONCLUSIONS
  25-(OH)D(3) may play an important role in the pathogenesis of asthma. The increased serum 25-(OH)D(3) level may inhibit total IgE expression, suggesting that increasing serum 25-(OH)D(3) level might be a new option for the prevention and treatment of asthma.
authors.affiliation: Department of Pediatrics, 253rd Hospital of People's Liberation Army, Huhhot, Inner Mongolia 010051, China.
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Ma
authors.forename: Yan-Fen
authors.initials: YF
authors.lastname: Zhen
mesh_terms: D001249:Asthma / Q000097:blood* / Q000209:etiology; D002112:Calcifediol / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D008297:Male
chemical_list: D007073:Immunoglobulin E; D002112:Calcifediol