title: Retro-orbital intraconal fat injection: an experimental study in rabbits.
abstract: OBJECTIVE
  Despite adequate treatment, enophthalmos due to intraconjunctival corticosteroid injection and enlargement of the bony orbit after trauma remains a frequent complication. The use of alloplastic material in addressing this problem is restricted because it may result in allergic reactions and is not cost-effective. The use of retro-orbital intraconal injection is the most effective method for maximum augmentation. An inexpensive and minimally invasive alternative that also allows for reoperation when needed would be a preferred intervention.
  
  
  METHODS
  We used 24 white rabbits (New Zealand) in our study. The animals were divided into 2 groups: a fat group and a saline solution group. The first group was subjected to retrobulbar fat injection, and the second group underwent physiologic saline solution injection. The volume of the retrobulbar area was measured and statistically evaluated both before and after the injections. Sonographically measured retrobulbar volumes were then statistically analyzed.
  
  
  RESULTS
  When the saline solution and fat groups were compared, no significant difference was observed between the preinjection volumes of the orbits. However, after injection, there was a significant difference between volumes. A statistically significant difference was shown between retro-orbital volumes calculated before the injection in the fat group and volumes calculated immediately after injection and in the following 4 months (right retro-orbital volume of 1.291 cm(3) ± 0.031 cm(3) before injection and 2.656 cm(3) ± 0.040 cm(3) in the fourth month, P < .05).
  
  
  CONCLUSIONS
  Volume augmentation by fat injection is superior to complicated surgical methods because of the advantages of decreased morbidity, rapid rehabilitation, and ease of reinjection. Using fat tissue as a filling material is more reliable, easier, and cheaper in comparison to other implantable materials.
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Trakya University Medical Faculty, Edirne, Turkey. bcakirus@yahoo.com
authors.forename: Beyhan
authors.initials: B
authors.lastname: Cakir
authors.forename: Ahmet Cemal
authors.initials: AC
authors.lastname: Aygit
authors.forename: Ozerk
authors.initials: O
authors.lastname: Omur-Okten
authors.forename: Omer
authors.initials: O
authors.lastname: Yalcin
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000473:pathology / Q000637:transplantation*; D000818:Animals; D002114:Calcinosis / Q000473:pathology; D015841:Enophthalmos / Q000601:surgery; D005094:Exophthalmos / Q000000981:diagnostic imaging; D005355:Fibrosis; D007267:Injections; D008297:Male; D019060:Minimally Invasive Surgical Procedures; D009915:Orbit / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D009929:Organ Size; D011817:Rabbits; D012965:Sodium Chloride; D020858:Tissue and Organ Harvesting / Q000379:methods; D014182:Transplantation, Autologous; D014463:Ultrasonography
chemical_list: D012965:Sodium Chloride