title: [Severe immune thrombocytopenia caused by interferon-beta in a patient with malignant melanoma].
abstract: A 57-year-old woman was diagnosed with malignant melanoma three years ago. She received pre- and post-operative therapy with DAV chemotherapy and Feron (Feron®, interferon-b, IFN-b). Thereafter, she received a monthly local injection of Feron®. Severe thrombocytopenia developed three years later. Immune pathogenesis was suspected since platelet-associated immunoglobulin G (PAIGg) was increased and the administration of prednisolone (PSL) quickly ameliorated the thrombocytopenia. This is the first report of severe immune thrombocytopenia caused by IFN-b. Local injections of Feron® were resumed; however, thrombocytopenia was not observed.
authors.affiliation: Dept. of Medicine, Towa Municipal Hospital, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Shinohara
authors.forename: Naoko
authors.initials: N
authors.lastname: Kambara
authors.forename: Toru
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000009:adverse effects* / Q000627:therapeutic use; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
chemical_list: D016899:Interferon-beta