title: Benzothiazole toxicity assessment in support of synthetic turf field human health risk assessment.
abstract: Synthetic turf fields cushioned with crumb rubber may be a source of chemical exposure to those playing on the fields. Benzothiazole (BZT) may volatilize from crumb rubber and result in inhalation exposure. Benzothiazole has been the primary rubber-related chemical found in synthetic turf studies. However, risks associated with BZT have not been thoroughly assessed, primarily because of gaps in the database. This assessment provides toxicity information for a human health risk assessment involving BZT detected at five fields in Connecticut. BZT exerts acute toxicity and is a respiratory irritant and dermal sensitizer. In a genetic toxicity assay BZT was positive in Salmonella in the presence of metabolic activation. BZT metabolism involves ring-opening and formation of aromatic hydroxylamines, metabolites with mutagenic and carcinogenic potential. A structural analogue 2-mercaptobenzothiazole (2-MBZT) was more widely tested and so is used as a surrogate for some endpoints. 2-MBZT is a rodent carcinogen with rubber industry data supporting an association with human bladder cancer. The following BZT toxicity values were derived: (1) acute air target of 110 μg/m(3) based upon a BZT RD(50) study in mice relative to results for formaldehyde; (2) a chronic noncancer target of 18 μg/m(3) based upon the no-observed-adverse-effect level (NOAEL) in a subchronic dietary study in rats, dose route extrapolation, and uncertainty factors that combine to 1000; (3) a cancer unit risk of 1.8E-07/μg-m(3) based upon a published oral slope factor for 2-MBZT and dose-route extrapolation. While there are numerous uncertainties in the BZT toxicology database, this assessment enables BZT to be quantitatively assessed in risk assessments involving synthetic turf fields. However, this is only a screening-level assessment, and research that better defines BZT potency is needed.
authors.affiliation: Connecticut Dept of Public Health, Hartford, Connecticut 06106, USA. gary.ginsberg@ct.gov
authors.forename: Gary
authors.initials: G
authors.lastname: Ginsberg
authors.forename: Brian
authors.initials: B
authors.lastname: Toal
authors.forename: Tara
authors.initials: T
authors.lastname: Kurland
mesh_terms: D000393:Air Pollutants / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D052160:Benzothiazoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D002274:Carcinogens, Environmental / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D020724:Elastomers / Q000737:chemistry*; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D007509:Irritants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity; D009153:Mutagens / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity; D018570:Risk Assessment; D019876:Sports Equipment / Q000009:adverse effects*; D055549:Volatile Organic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D000393:Air Pollutants; D052160:Benzothiazoles; D002274:Carcinogens, Environmental; D020724:Elastomers; D007509:Irritants; D009153:Mutagens; D055549:Volatile Organic Compounds; C005465:benzothiazole