title: [Influence of microsatellite instability on survival of patients with sporadic colorectal cancer in China].
abstract: OBJECTIVE
  To investigate the role of microsatellite instability(MSI) in Chinese sporadic coloretal cancer.
  
  
  METHODS
  A total of 146 patients with colorectal cancer were treated surgically from August 2004 to September 2006 in the Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine. Data were collected prospectively. Univariate and multivariable analyses were performed for parameters such as age, gender, tumor location, differentiation, MSI, tumor type, lymph node metastasis, TNM stage, and survival.
  
  
  RESULTS
  Follow-up was available in 134 patients including telephone call and office visit. MSI(P=0.029), tumor type(P=0.000), TNM stage(P=0.000) were independently associated with survival on Cox regression model. There were 26 patients with MSI, and the 1-, 3-, and 5-year survival rates were 100%, 92.3%, and 92.3%, respectively. The remaining 108 patients had microsatellite stable tumor, and the 1-, 3-, and 5-year survival rates were 96.3%, 72.2%, and 63.5%, respectively. The difference was statistically significant(P=0.016).
  
  
  CONCLUSIONS
  Microsatellite instability is an important factor associated with patient survival in Chinese sporadic colorectal cancer.
authors.affiliation: National Center of Colorectal Surgery, The Third Affiliated Hospital, Nanjing University of Traditional Chinese Medicine, China.
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Hei-ying
authors.initials: HY
authors.lastname: Jin
authors.forename: Yi-jiang
authors.initials: YJ
authors.lastname: Ding
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Fan
authors.forename: Xiu-fang
authors.initials: XF
authors.lastname: Liu
authors.forename: Jian-xiang
authors.initials: JX
authors.lastname: Gen
mesh_terms: D000368:Aged; D002681:China; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D053842:Microsatellite Instability; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate