title: Sphenoidal electrodes significantly change the results of source localization of interictal spikes for a large percentage of patients with temporal lobe epilepsy.
abstract: Although scalp EEG is a very useful tool for presurgical evaluation in epilepsy, the 10-20 system of electrodes in many cases fails to accurately localize the source of the epileptic seizures. One suggested solution to this problem is to use additional electrodes. Sphenoidal electrodes especially have been suggested to be helpful in identifying the irritative and seizure onset zones in patients with temporal lobe epilepsy. However, the value of these electrodes has been debated, and in many epilepsy centers they are not used. In this study, we investigate the impact of sphenoidal electrodes by comparing the results of EEG source localization with and without sphenoidal recordings. We retrospectively selected patients with temporal lobe epilepsy based on their clinical semiology and electrophysiologic data. For each patient, a prototype spike was used as a template for an automatic pattern search to find similar activities. The identified spikes were then averaged and analyzed by fitting a dipole to the data. The recordings from sphenoidal electrodes were then excluded and the analysis was repeated. It was found that in more than half of the patients inclusion of sphenoidal electrodes resulted in a shift of more than 2 cm in the location of the fitted dipole, and in some cases moved the dipole from the frontal lobe or the insula to the temporal lobe. Our results suggest that sphenoidal electrodes are helpful in the analysis of the EEG recordings of patients suspected of having temporal lobe epilepsy.
authors.affiliation: Neurological Institute, University Hospitals, Cleveland, Ohio 44106, USA. mehdi.hamaneh@UHhospitals.org
authors.forename: Mehdi B
authors.initials: MB
authors.lastname: Hamaneh
authors.forename: Chusak
authors.initials: C
authors.lastname: Limotai
authors.forename: Hans O
authors.initials: HO
authors.lastname: Lüders
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000328:Adult; D000368:Aged; D004566:Electrodes / Q000592:standards; D004569:Electroencephalography / Q000295:instrumentation* / Q000592:standards; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013100:Sphenoid Bone / Q000502:physiology*; D055815:Young Adult