title: Mouse strains for the ubiquitous or conditional overexpression of the Flii gene.
abstract: The gelsolin related actin binding protein, Flii, is able to regulate wound healing; mice with decreased Flii expression show improved wound healing whereas mice with elevated Flii expression exhibit impaired wound healing. In both mice and humans Flii expression increases with age and amelioration of FLII activity represents a possible therapeutic strategy for improved wound healing in humans. Despite analysis of Flii function in a variety of organisms we know little of the molecular mechanisms underlying Flii action. Two new murine alleles of Flii have been produced to drive constitutive or tissue-specific expression of Flii. Each strain is able to rescue the embryonic lethality associated with a Flii null allele and to impair wound healing. These strains provide valuable resources for ongoing investigation of Flii function in a variety of biological processes.
authors.affiliation: Centre for Molecular Genetics of Development, Research School of Biology, The Australian National University, Canberra, ACT, Australia.
authors.forename: Nicole
authors.initials: N
authors.lastname: Thomsen
authors.forename: Anna
authors.initials: A
authors.lastname: Chappell
authors.forename: Radiya G
authors.initials: RG
authors.lastname: Ali
authors.forename: Tamsin
authors.initials: T
authors.lastname: Jones
authors.forename: Damian H
authors.initials: DH
authors.lastname: Adams
authors.forename: Klaus I
authors.initials: KI
authors.lastname: Matthaei
authors.forename: Hugh D
authors.initials: HD
authors.lastname: Campbell
authors.forename: Allison J
authors.initials: AJ
authors.lastname: Cowin
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Arkell
mesh_terms: D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D005838:Genotype; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000378:metabolism* / Q000503:physiopathology; D013045:Species Specificity; D013154:Spleen / Q000378:metabolism; D013997:Time Factors; D015534:Trans-Activators; D014945:Wound Healing / Q000235:genetics* / Q000502:physiology
chemical_list: D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; C098179:FLII protein, human; C000609263:FlII protein, mouse; C110853:Gt(ROSA)26Sor non-coding RNA, mouse; D008840:Microfilament Proteins; D011506:Proteins; D022661:RNA, Untranslated; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators