title: Succinate receptors in the kidney.
abstract: The G protein-coupled succinate and α-ketoglutarate receptors are closely related to the family of P2Y purinoreceptors. Although the α-ketoglutarate receptor is almost exclusively expressed in the kidney, its function is unknown. In contrast, the succinate receptor, SUCRN1, is expressed in a variety of tissues, including blood cells, adipose tissue, liver, retina, and the kidney. Recent evidence suggests SUCRN1 and its succinate ligand are novel detectors of local stress, including ischemia, hypoxia, toxicity, and hyperglycemia. Local levels of succinate in the kidney also activate the renin-angiotensin system and together with SUCRN1 may play a key role in the development of hypertension and the complications of diabetes mellitus, metabolic disease, and liver damage. This makes the succinate receptor a promising drug target to counteract an expanding number of interrelated disorders.
authors.affiliation: Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.
authors.forename: Peter M T
authors.initials: PM
authors.lastname: Deen
authors.forename: Joris H
authors.initials: JH
authors.lastname: Robben
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D002952:Citric Acid Cycle; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism; D008066:Lipolysis; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D010802:Phylogeny; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D058470:Receptors, Purinergic P2Y / Q000378:metabolism; D012164:Retinal Diseases / Q000473:pathology; D013386:Succinates / Q000737:chemistry / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D043562:Receptors, G-Protein-Coupled; D058470:Receptors, Purinergic P2Y; D013386:Succinates