title: Concurrent gastric MALT and Hodgkin lymphoma: a case report.
abstract: This report describes a 60-year-old man with concurrent gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and classical Hodgkin lymphoma (CHL). Atypical, medium-sized, lymphoid cells proliferated in the mucosa to muscular layer of the stomach showing a lymphoepithelial lesion; admixed with Hodgkin/Reed-Sternberg (HRS) cells and an inflammatory cell background. MALT lymphoma cells expressed CD20, CD79a, PAX5, and BOB.1, and HRS cells expressed CD30, CD15, Epstein-Barr virus-encoded RNA, and EBV-latent membrane protein 1. Only CHL invaded into the regional lymph nodes. Two possibilities of transformation of MALT lymphoma into CHL and de novo CHL within MALT lymphoma are discussed.
authors.affiliation: Department of Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan. oka-k@gb3.so-net.ne.jp
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Oka
authors.forename: Reizo
authors.initials: R
authors.lastname: Nagayama
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yonekawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nihei
authors.forename: Norimasa
authors.initials: N
authors.lastname: Sando
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yatabe
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Mori
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D003131:Combined Modality Therapy; D058617:Composite Lymphoma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D017809:Fatal Outcome; D005753:Gastric Mucosa / Q000473:pathology; D006689:Hodgkin Disease / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008297:Male; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary; D016539:Reed-Sternberg Cells / Q000473:pathology; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor