title: Quantitative Estimation of IL-6 in Serum/Plasma Samples Using a Rapid and Cost-Effective Fiber-Optic dip-probe.
abstract: A rapid and cost-effective combination tapered fiber-optic biosensor (CTFOB) dip-probe was used for quantitative estimation of interleukin (IL)-6 in serum/plasma samples. Sandwich immunoassay was used as the detection technique. Probes could successfully detect presence of IL-6 in two serum samples, non-neoplastic autoimmune patient (lupus) sample and lymphoma patient sample. The estimated amount of IL-6 in lupus patient sample was 4.8 ± 0.9 pM and in lymphoma patient sample was 2 ± 1 pM. It is demonstrated that the developed CTFOB dip-probe is capable of quantitative estimation of proteins in serum/plasma samples with high specificity.
authors.affiliation: Department of Physics, University of Alabama at Birmingham, Birmingham, AL 35294.
authors.forename: Chun Wei
authors.initials: CW
authors.lastname: Wang
authors.forename: Upender
authors.initials: U
authors.lastname: Manne
authors.forename: Vishnu B
authors.initials: VB
authors.lastname: Reddy
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kapoor