title: One-pot synthesis of pyrazoline derivatised carbazoles as antitubercular, anticancer agents, their DNA cleavage and antioxidant activities.
abstract: Novel tricyclic carbazoles 4a-k were synthesized in one-pot employing sydnone derivatives 3a-k as masked hydrazines by the ring transformation in presence of conc. HCl and cyclohexanone. The title compounds were screened for anti-tubercular, anti cancer, DNA cleavage, antioxidant activity. MIC, GI50, LC50, TGI were evaluated. The title compounds have exhibited significant antitubercular, DNA cleavage and antioxidant activities and partial anticancer activity.
authors.affiliation: PG Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580 003, India.
authors.forename: Tasneem
authors.initials: T
authors.lastname: Taj
authors.forename: Ravindra R
authors.initials: RR
authors.lastname: Kamble
authors.forename: T M
authors.initials: TM
authors.lastname: Gireesh
authors.forename: Raveendra K
authors.initials: RK
authors.lastname: Hunnur
authors.forename: Sheetal B
authors.initials: SB
authors.lastname: Margankop
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D000995:Antitubercular Agents; D002227:Carbazoles; D011720:Pyrazoles; D004247:DNA