title: Unsymmetrical β-cyclodextrin-conjugated silicon(IV) phthalocyanines as highly potent photosensitisers for photodynamic therapy.
abstract: A series of unsymmetrical silicon(IV) phthalocyanines with a permethylated β-cyclodextrin unit and a sugar or a diamino moiety as the axial substituents have been prepared. These compounds are highly photocytotoxic with IC(50) values as low as 21 nM, which is ca. sevenfold lower than those of the symmetrical bis(cyclodextrin) analogue.
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China.
authors.forename: Janet T F
authors.initials: JT
authors.lastname: Lau
authors.forename: Pui-Chi
authors.initials: PC
authors.lastname: Lo
authors.forename: Yee-Man
authors.initials: YM
authors.lastname: Tsang
authors.forename: Wing-Ping
authors.initials: WP
authors.lastname: Fong
authors.forename: Dennis K P
authors.initials: DK
authors.lastname: Ng
mesh_terms: D000818:Animals; D019073:HT29 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D012825:Silicon / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D047392:beta-Cyclodextrins; C013647:phthalocyanine; D012825:Silicon