title: Arterial stiffness is associated with minimally elevated high-sensitivity cardiac, troponin T levels in a community-dwelling population.
abstract: OBJECTIVE
  Arterial stiffness predicts an increased risk of future cardiovascular events, possibly via myocardial damage. Minimally elevated levels of plasma cardiac troponin T (TnT), a marker of cardiomyocyte injury, can be detected by the high-sensitivity TnT (hsTnT) assay. The current study investigated the relationship between plasma hsTnT levels and alterations in arterial stiffness in a community-based population.
  
  
  METHODS
  We related levels of plasma hsTnT to measures of arterial stiffness (carotid-femoral pulse wave velocity [PWV], office pulse pressure [PP] and carotid-radial PWV) in 1479 participants (mean age, 62.3 years; 619 men, 860 women) from a community-based population in Beijing, China.
  
  
  RESULTS
  In multiple logistic regression models, carotid-femoral PWV (OR: 1.84; 95% CI: 1.06-3.17; P=0.028) and office PP (OR: 2.02; 95% CI: 1.31-3.11; P=0.002) were associated with a higher likelihood of detectable hsTnT. In addition, carotid-femoral PWV (OR: 2.34; 95% CI: 1.03-5.30; P=0.042) and office PP (OR: 2.30; 95% CI: 1.13-4.66; P=0.022) were significantly related to elevated hsTnT levels. A subsequent subgroup analysis found that, in subjects aged 60 years and older, the associations between carotid-femoral PWV and office PP and hsTnT levels were strengthened. The associations between hsTnT with any of the arterial stiffness measures were not present in the younger subgroup (<60 years old).
  
  
  CONCLUSIONS
  Carotid-femoral PWV and office PP are associated with minimally elevated hsTnT levels in the elderly, indicating a relationship between central artery stiffness and subclinical myocardial damage.
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Bai
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.forename: Leiming
authors.initials: L
authors.lastname: Luo
authors.forename: Wenkai
authors.initials: W
authors.lastname: Xiao
authors.forename: Ruyi
authors.initials: R
authors.lastname: Xu
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002339:Carotid Arteries / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D005263:Femoral Artery / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D016017:Odds Ratio; D012372:ROC Curve; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000097:blood*; D059289:Vascular Stiffness
chemical_list: D020107:Troponin T