title: Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect.
abstract: Bambusae caulis in Liquamen (BCL), traditional herbal medicine used in East Asia, is known to have antioxidative and immune-regulating properties. We hypothesized that the potential antioxidant effects of BCL might suppress the production of thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in human keratinocytes (HaCaT cell). The immune-regulating effect of BCL was demonstrated by antioxidant capacity using DPPH analysis and DCFH-DA analysis. We found that BCL had strong ROS scavenge effect in HaCaT cell. BCL also showed suppression of IFN-γ-induced expression of TARC and MDC, activation of NF-κB, and, moreover, significant block of IFN-γ-induced degradation and phosphorylation of IκB. However, it had no effects on phosphorylation of p38 MAPK. Collectively, these results suggest that BCL may have a therapeutic potential on skin disease such as atopic dermatitis by inhibiting Th2 chemokines which is due, at least in part, to its antioxidant capacities.
authors.affiliation: Key Laboratory for Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou 510632, China.
authors.forename: Xu-Feng
authors.initials: XF
authors.lastname: Qi
authors.forename: Dong-Heui
authors.initials: DH
authors.lastname: Kim
authors.forename: Yang-Suk
authors.initials: YS
authors.lastname: Yoon
authors.forename: Soon-Bong
authors.initials: SB
authors.lastname: Song
authors.forename: Yung-Chien
authors.initials: YC
authors.lastname: Teng
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Cai
authors.forename: Kyu-Jae
authors.initials: KJ
authors.lastname: Lee