title: Endogenous allergen upregulation: transgenic vs. traditionally bred crops.
abstract: The safety assessment for transgenic food crops currently includes an evaluation of the endogenous allergy potential (via serum IgE screening) when the non-transgenic counterpart is a commonly allergenic food. The value of this analysis in the safety assessment of transgenic crops, especially with reference to recent requests to quantify individual allergen concentrations in raw commodities, is examined. We conclude that the likelihood of upregulating an endogenous allergen due to transgenesis is no greater than from traditional breeding which has a history of safety and is largely unregulated. The potential consequences of upregulating an endogenous allergen are also unclear.
authors.affiliation: Dow AgroSciences LLC, 9330 Zionsville Rd., Indianapolis, IN 46268, USA. raherman@dow.com
authors.forename: Rod A
authors.initials: RA
authors.lastname: Herman
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Ladics
mesh_terms: D000485:Allergens / Q000096:biosynthesis / Q000235:genetics*; D005512:Food Hypersensitivity / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D030821:Plants, Genetically Modified / Q000235:genetics / Q000276:immunology*; D015854:Up-Regulation / Q000276:immunology
chemical_list: D000485:Allergens