title: G-quadruplex DNAzyme based molecular catalytic beacon for label-free colorimetric logic gates.
abstract: Efficient and economic DNA nanomaterials that can work as logic components are necessary for the development of DNA computers with high speed and outstanding data storage capacity. A new molecular catalytic beacon (MCB) and a series of label-free colorimetric logic gates based on the formation and dissociation of G-quadruplex DNAzyme were established in this work. These logic gates (NOT, NOR, IMPLICATION, AND, OR and INHIBIT) were realized by the interaction between the special designed oligonucleotide hairpins and the short input single strand complementary DNA. We were able to recognize the logic output signals effortlessly by our naked eyes. It is a simple, economic and safe approach for the design of complex multiple input DNA logic molecular device.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Zhu
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Libing
authors.initials: L
authors.lastname: Zhang
authors.forename: Shaojun
authors.initials: S
authors.lastname: Dong
authors.forename: Erkang
authors.initials: E
authors.lastname: Wang
mesh_terms: D001483:Base Sequence; D003124:Colorimetry / Q000379:methods*; D039301:Computers, Molecular; D021881:DNA, Catalytic / Q000378:metabolism*; D054856:G-Quadruplexes; D008969:Molecular Sequence Data
chemical_list: D021881:DNA, Catalytic