title: Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes.
abstract: GABA(A) receptors mediate fast synaptic inhibitory neurotransmission throughout the central nervous system. Recent work indicates a role for GABA(A) receptors in physiologically modulating anxiety and depression levels. In this review, we summarize research that led to the identification of the essential role of GABA(A) receptors in counteracting trait anxiety and depression-related behaviors, and research aimed at identifying individual GABA(A) receptor subtypes involved in physiological and pharmacological modulation of emotions. This article is part of a Special Issue entitled 'Anxiety and Depression'.
authors.affiliation: Laboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA, USA.
authors.forename: Kiersten S
authors.initials: KS
authors.lastname: Smith
authors.forename: Uwe
authors.initials: U
authors.lastname: Rudolph
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000235:genetics*; D003863:Depression / Q000188:drug therapy* / Q000235:genetics*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D011963:Receptors, GABA-A / Q000502:physiology*
chemical_list: D000928:Antidepressive Agents; D011963:Receptors, GABA-A