title: [Goal-directed fluid management prevents gastrointestinal complications in abdominal surgery: a meta-analysis of randomized controlled trials].
abstract: OBJECTIVE
  To assess whether goal-directed fluid management can prevent gastrointestinal complications in major surgery.
  
  
  METHODS
  Electronic databases including Cochrane library(Issue 3,2010), Pubmed, EMbase, Highwire, CBM, and CNKI were searched. The date of search was between January 2000 and December 2010. Randomized controlled trials(RCTs) were indentified studying association of goal-directed therapy (GDT) with gastrointestinal complications. Study selection and meta-analysis were conducted according to the Cochrane Handbook for systematic reviews. Data were extracted from these trials by 3 reviewers independently and analyzed by RevMan 5.0 software.
  
  
  RESULTS
  Ten trials involving 775 patients were included. GDT significantly improved oxygen supply(WMD=82.95, 95% CI: 17.43-148.46). GDT reduced postoperative hospital stay(WMD=-2.06, 95% CI: -2.95 - -1.17) and decreased postoperative complication rate after major surgery(RR=0.39, 95% CI: 0.29-0.52).
  
  
  CONCLUSIONS
  Goal-directed fluid management can stabilize cardiac output, augment oxygen supply, and therefore reduce postoperative complications.
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Guo
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.forename: Jian-rong
authors.initials: JR
authors.lastname: Ye
authors.forename: Hui-cai
authors.initials: HC
authors.lastname: Wang
mesh_terms: D000005:Abdomen / Q000601:surgery; D005440:Fluid Therapy / Q000379:methods*; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic