title: Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis.
abstract: A 4-year-old boy presented with proteinuria and developed progressive renal failure over 6 years. In the patient's family, five individuals were affected with atypical haemolytic uraemic syndrome (aHUS) but not the patient. Renal biopsies (n = 3) showed glomerular basement membrane thickening with double contours, endothelial swelling and deposits of C3 and C1q. Electron microscopy revealed mesangial and subendothelial electron-dense deposits. Complement mutations in membrane cofactor protein (Y155D) and C3 (R713W and G1094R) were detected in all affected family members. The patient also had transient autoantibodies to factor H. The findings suggest that aHUS and glomerulopathy resembling membranoproliferative glomerulonephritis may have a common molecular background.
authors.affiliation: Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
authors.forename: Damien
authors.initials: D
authors.lastname: Brackman
authors.forename: Lisa
authors.initials: L
authors.lastname: Sartz
authors.forename: Sabine
authors.initials: S
authors.lastname: Leh
authors.forename: Ann-Charlotte
authors.initials: AC
authors.lastname: Kristoffersson
authors.forename: Anna
authors.initials: A
authors.lastname: Bjerre
authors.forename: Ramesh
authors.initials: R
authors.lastname: Tati
authors.forename: Veronique
authors.initials: V
authors.lastname: Frémeaux-Bacchi
authors.forename: Diana
authors.initials: D
authors.lastname: Karpman
mesh_terms: D002675:Child, Preschool; D003176:Complement C3 / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008297:Male; D051916:Membrane Cofactor Protein / Q000235:genetics; D009154:Mutation / Q000235:genetics; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011379:Prognosis; D011507:Proteinuria / Q000150:complications*; D057049:Thrombotic Microangiopathies / Q000175:diagnosis* / Q000209:etiology
chemical_list: D003176:Complement C3; D051916:Membrane Cofactor Protein