title: Antimalarial activity in Xylocarpus granatum (Koen).
abstract: The antimalarial activity of Xylocarpus granatum fruits and their active constituents gedunin and xyloccensin-I were investigated using an in vitro model in this study. The chloroform fraction of X. granatum fruits was found to show promising antimalarial activity using an in vitro model of Plasmodium falciparum. On purification of the active fraction, four pure compounds were isolated and characterised, namely gedunin, photogedunin, xyloccensin-I and palmitic acid. Out of these only gedunin and xyloccensin-I were found to show activity equivalent to the parent active fraction in vitro model.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow-226001, India. vijai_lakshmi@cdri.res.in
authors.forename: Vijai
authors.initials: V
authors.lastname: Lakshmi
authors.forename: Shishir
authors.initials: S
authors.lastname: Srivastava
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Mishra
authors.forename: Mahendra Nath
authors.initials: MN
authors.lastname: Srivastava
authors.forename: Kumkum
authors.initials: K
authors.lastname: Srivastava
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Puri
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D010936:Plant Extracts