title: [M-29 human diploid cells line--a substrate for the production of antiviral vaccines].
abstract: OBJECTIVE
  Study of morphologic and karyologic characteristics of 5 russian human diploid cell lines (HDC).
  
  
  METHODS
  5 HDC lines and HDC strain MRC-5 were studied; RK-13 and Vero continuous cell lines were used; viruses: rubella (RA27/3), measles (L-16), epidemic parotitis (L-3). Cytogenetic analysis of HDC was performed by using DAPI differential staining method.
  
  
  RESULTS
  M-29 line has characteristics that are similar to those of MRC-5 diploid cell strain. M-29 cell culture is not contaminated with foreign viruses, mycoplasmata, does not have oncogenic potency.
  
  
  CONCLUSIONS
  M-29 line has high virus-productive properties for accumulation of measles, rubella and epidemic parotitis vaccine viruses and may be recommended as a substrate for the production of antiviral vaccines.
authors.forename: T K
authors.initials: TK
authors.lastname: Borisova
authors.forename: V V
authors.initials: VV
authors.lastname: Zverev
authors.forename: L L
authors.initials: LL
authors.lastname: Mironova
authors.forename: O I
authors.initials: OI
authors.lastname: Koniushko
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Zabiiaka
authors.forename: N R
authors.initials: NR
authors.lastname: Shukhmina
authors.forename: V I
authors.initials: VI
authors.lastname: Vashchenko
mesh_terms: D002460:Cell Line; D004171:Diploidy; D006801:Humans; D008457:Measles / Q000517:prevention & control; D018103:Morbillivirus / Q000254:growth & development / Q000302:isolation & purification*; D009107:Mumps / Q000517:prevention & control; D009109:Mumps virus / Q000254:growth & development / Q000302:isolation & purification*; D014765:Viral Vaccines; D014776:Virus Cultivation / Q000379:methods*
chemical_list: D014765:Viral Vaccines