title: Safety and efficacy of a splenectomy during debulking surgery for Müllerian carcinoma.
abstract: OBJECTIVE
  This study was designed to assess the safety and efficacy of a splenectomy and to analyze the prognostic factors of Müllerian carcinoma with spleen metastasis.
  
  
  METHODS
  We reviewed the medical records of 11 patients with Müllerian carcinoma who underwent a splenectomy between 1997 and 2007. The treatment outcome of these patients was examined and the possible prognostic factors were investigated by univariate analysis.
  
  
  RESULTS
  Four and seven patients underwent a splenectomy for primary and recurrent disease, respectively. A complete resection was achieved in eight patients. A blood transfusion was not required and only two mild postoperative complications were observed. The median and five-year survivals of all patients following treatment were 39 months and 39%, respectively. Older patients (> or = 60 years old) and patients with a poor performance status (PS2) had a poorer prognosis by univariate analysis.
  
  
  CONCLUSIONS
  A splenectomy can be performed safely and effectively during debulking surgery for appropriately selected patients with primary or recurrent Müllerian carcinoma.
authors.affiliation: Gynecologic Oncology Division, National Cancer Center Hospital, Tokyo, Japan. tak-uehara@hospital.chiba-u.jp
authors.forename: T
authors.initials: T
authors.lastname: Uehara
authors.forename: T
authors.initials: T
authors.lastname: Onda
authors.forename: S
authors.initials: S
authors.lastname: Togami
authors.forename: T
authors.initials: T
authors.lastname: Amano
authors.forename: M
authors.initials: M
authors.lastname: Tanikawa
authors.forename: M
authors.initials: M
authors.lastname: Sawada
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Kasamatsu
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D005185:Fallopian Tube Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009095:Mullerian Ducts / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery*; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D013154:Spleen / Q000473:pathology / Q000601:surgery*; D013156:Splenectomy / Q000009:adverse effects*; D016896:Treatment Outcome