title: [Impact of alcohol use disorder on mortality: are there age and gender differences?].
abstract: OBJECTIVE
  To estimate excess mortality in patients with an alcohol use disorder and to calculate the population-based impact attributable to this disorder, with emphasis on differences according to gender and age.
  
  
  METHODS
  We carried out a longitudinal study of a dynamic retrospective cohort in which 7,109 patients (76.5% men) aged 18-64 years who started medical day treatment between 1997 and 2006 were recruited. Deaths were monitored until the end of 2006 using a national mortality register. Standardized mortality ratios (SMR) by age and gender and population attributable risks (PAR) by age group were estimated.
  
  
  RESULTS
  There were 557 deaths (83% were men). The total excess mortality was 8 times higher than in the general population aged 18-64 years, especially in the group aged 25-34 years old (SMR: 11.2 [95% CI: 7.8-16.0] in men and 24 [IC95%: 11.5-50.4] in women). Significant differences by gender were found in all the variables analyzed. In Barcelona, alcohol use disorder was estimated to cause 73 deaths per year, representing 3.3% of the total annual deaths in this city in persons aged 18-64 years. This percentage was substantially higher in the groups aged 25-34 years (PAR: 19.4% [95% CI: 19.2-19.6]) and 18-24 years (PAR: 11.1% [95% CI: 10.7-11.4]).
  
  
  CONCLUSIONS
  Women and young men with an alcohol use disorder have a higher risk of early mortality. Early detection of problematic alcohol consumption and selective and well-indicated prevention programs should be improved.
authors.affiliation: Agència de Salut Pública de Barcelona, España. aguitart@aspb.cat
authors.forename: Anna M
authors.initials: AM
authors.lastname: Guitart
authors.forename: Albert
authors.initials: A
authors.lastname: Espelt
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Castellano
authors.forename: Montse
authors.initials: M
authors.lastname: Bartroli
authors.forename: Joan R
authors.initials: JR
authors.lastname: Villalbí
authors.forename: Antonia
authors.initials: A
authors.lastname: Domingo-Salvany
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Brugal
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D020751:Alcohol-Induced Disorders / Q000401:mortality*; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology; D008875:Middle Aged; D012189:Retrospective Studies; D012306:Risk; D012737:Sex Factors; D012959:Socioeconomic Factors; D013030:Spain / Q000453:epidemiology; D014505:Urban Population / Q000706:statistics & numerical data; D055815:Young Adult