title: Correlation of body mass index with outcome of in vitro fertilization in a developing country.
abstract: OBJECTIVE
  To correlate ovarian response to stimulation and IVF outcome according to the women's body mass index (BMI).
  
  
  METHODS
  Records of all patients who underwent IVF cycle in our institution from January 2008 to October 2010 were reviewed retrospectively. Three hundred and twenty-eight patients underwent 342 in vitro fertilization (IVF) cycles or intra-cytoplasmic sperm injection (ICSI) and were divided into four subgroups according to BMI; underweight, BMI < 18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; and obese, >30.0.
  
  
  RESULTS
  In our study, with increasing BMI negative co-relation was seen with clinical pregnancy rate (CPR) (P value = 0.040). Increased doses of gonadotropins were required with increase in patients BMI (P value = 0.045). In the present study, no difference was seen in the number of oocyte retrieved but a decreased fertilization and cleavage rate was seen with decreased number of cryo-preserved embryos with increasing BMI. This study shows that poorer oocyte quality is seen with increasing BMI which results in reduced CPR. In our study no deleterious effect of low BMI was seen on IVF outcome and CPR.
  
  
  CONCLUSIONS
  Female obesity impairs IVF outcome potentially by impairing oocyte quality but does not affect ovarian response to stimulation.
authors.affiliation: Department of Obstetrics and Gynecology, AIIMS, New Delhi, India.
authors.forename: Neeta
authors.initials: N
authors.lastname: Singh
authors.forename: Prerna
authors.initials: P
authors.lastname: Gupta
authors.forename: Suneeta
authors.initials: S
authors.lastname: Mittal
authors.forename: Neena
authors.initials: N
authors.lastname: Malhotra
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003906:Developing Countries; D005260:Female; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000627:therapeutic use; D006801:Humans; D009765:Obesity / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D006062:Gonadotropins