title: Cypermethrin alters Glial Fibrillary Acidic Protein levels in the rat brain.
abstract: Pyrethroids, widely used insecticides, are biologically active in neurons. Whether they act on the non-neuronal brain cells remains an open question. Thus, the aim of this study was to examine whether Cypermethrin intoxication affects astroglial cells in the rat brain. The levels of Glial Fibrillary Acidic Protein (GFAP) in different brain regions were measured by ELISA following oral treatment with 5 or 10% of LD(50) of Cypermethrin per day for 6 days. A significant decrease of GFAP was observed in different brain regions of treated animals. The cerebral cortex showed the most pronounced effect with GFAP levels reduced to 81% of the controls 2 days after treatment and 77% 21 days after treatment. Although we did not find profound changes in the morphology of astrocytes in Cypermethrin treated animals, the decrease in GFAP suggests that astrocytes were affected by low doses of pyrethroids. The possible consequences were discussed.
authors.affiliation: Department of Toxicology, Medical University of Warsaw, Pharmaceutical Faculty, Warsaw, Poland; Karolinska Institutet, Neurotec, Section of Experimental Geriatrics, KFC, Novum, 141 86 Stockholm, Sweden.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Malkiewicz
authors.forename: Marcin
authors.initials: M
authors.lastname: Koteras
authors.forename: Ronnie
authors.initials: R
authors.lastname: Folkesson
authors.forename: Jacek
authors.initials: J
authors.lastname: Brzezinski
authors.forename: Bengt
authors.initials: B
authors.lastname: Winblad
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Szutowski
authors.forename: Eirikur
authors.initials: E
authors.lastname: Benedikz