title: Hippocampal synaptic activity, pattern separation and episodic-like memory: implications for mouse models of Alzheimer's disease pathology.
abstract: The present review summarizes converging evidence from animal and human studies that an early target of amyloid pathology is synaptic activity in the DG (dentate gyrus)/CA3 network. We briefly review the computational significance of the DG/CA3 network in the encoding of episodic memory and present new evidence that the CA3/DG pattern of activation is compromised in a mouse model of amyloid pathology. In addition, we present a new behavioural method to test the prediction that amyloid-related synaptic pathology will disrupt the formation of an integrated episodic-like (what, where and when) memory in mice.
authors.affiliation: School of Psychology, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
authors.forename: Alice
authors.initials: A
authors.lastname: Palmer
authors.forename: Mark
authors.initials: M
authors.lastname: Good
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D011939:Mental Recall; D051379:Mice; D008822:Mice, Transgenic; D009435:Synaptic Transmission
chemical_list: D016229:Amyloid beta-Peptides