title: Overexpression of GLUT1 in colorectal cancer is independently associated with poor prognosis.
abstract: BACKGROUND
  To investigate the expression of glucose transporter 1 (GLUT1) in colorectal cancer (CRC) and its relationship to clinicopathological variables.
  
  
  METHODS
  The expression of GLUT1 in 163 primary tumors together with the corresponding normal mucosa, and 36 liver metastases was examined using real-time PCR.
  
  
  RESULTS
  The mean value of GLUT1 was higher in primary tumors (50.390 ± 68.648) than in the corresponding normal mucosa (20.437 ± 28.703, p<0.0001), while there was no significant difference in GLUT1 expression between CRC and liver metastasis (50.390 ± 68.648 vs 52.277 ± 52.482, p=0.190). In CRCs, GLUT1 expression was higher in poorly differentiated than in well and moderately differentiated tumors (p=0.022), and higher in stage III + IV than in stage I + II tumors (p=0.035). The patients with high-expressed GLUT1 had a worse prognosis than those with low-expressed GLUT1 independently of gender, age, tumor site, stage and differentiation (p=0.026, RR 2.737, 95% CI 1.126-6.651) in stage I-III CRCs. In liver metastasis, GLUT1 expression was higher in larger tumors than in smaller ones (p=0.025).
  
  
  CONCLUSIONS
  Overexpression of GLUT1 in stage I-III CRCs was independently associated with poor prognosis.
authors.affiliation: Division of Oncology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping University, Linköping - Sweden and Department of Pathology, West China Second University Hospital, SiChuan University, Chengdu - China.
authors.forename: Yang-Mei
authors.initials: YM
authors.lastname: Shen
authors.forename: Gunnar
authors.initials: G
authors.lastname: Arbman
authors.forename: Birgit
authors.initials: B
authors.lastname: Olsson
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Sun
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D051272:Glucose Transporter Type 1 / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor; D051272:Glucose Transporter Type 1; C495677:SLC2A1 protein, human