title: [Analysis of the polymorphic variants of the PDE4D gene in patients with acute stroke in the Moldavian population].
abstract: The risk of the ischemic stroke is mediated by both environmental and genetic factors. Recent studies of DeCode group identified the risk of polymorphisms for ischemic stroke in the phosphodiesterase 4D gene (PDE4D). The goal of this study was to explore the role of two variants of the gene encoding PDE4D [SNP41 (rs152312) and SNP87 (rs2910829)] in the Moldavian patients with ischemic stroke and in control. No significant association with ischemic stroke was observed with SNP41 and 87.
authors.forename: E A
authors.initials: EA
authors.lastname: Bondarenko
authors.forename: E I
authors.initials: EI
authors.lastname: Mokan
authors.forename: N I
authors.initials: NI
authors.lastname: Barbakar
authors.forename: T V
authors.initials: TV
authors.lastname: Tupitsyna
authors.forename: P A
authors.initials: PA
authors.lastname: Slominskiĭ
authors.forename: I M
authors.initials: IM
authors.lastname: Shetova
authors.forename: N A
authors.initials: NA
authors.lastname: Shamalov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Botsina
authors.forename: V I
authors.initials: VI
authors.lastname: Skvortsova
authors.forename: S A
authors.initials: SA
authors.lastname: Limborskaia
mesh_terms: D000328:Adult; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3 / Q000235:genetics*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D005260:Female; D056726:Genetic Association Studies; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D008966:Moldova; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012426:Russia; D020521:Stroke / Q000235:genetics*
chemical_list: D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517376:PDE4D protein, human