title: Effect of mesoporous silica under Neisseria meningitidis transformation process: environmental effects under meningococci transformation.
abstract: BACKGROUND
  This study aimed the use of mesoporous silica under the naturally transformable Neisseria meningitidis, an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under N. meningitidis transformation specifically under the capsular replacement.
  
  
  METHODS
  we used three different mesoporous silica particles to verify their action in N. meningitis transformation frequency.
  
  
  RESULTS
  we verified the increase in the capsular gene replacement of this bacterium with the three mesoporous silica nanoparticles.
  
  
  CONCLUSIONS
  the mesouporous silica particles were capable of increasing the capsule replacement frequency in N. meningitidis.
authors.affiliation: Department of Biochemistry, Institute of Biology CP6109, State University of Campinas UNICAMP, CP: 6109-CEP 13083-970, Campinas, SP, Brazil.
authors.forename: Luciana M
authors.initials: LM
authors.lastname: Hollanda
authors.forename: Gisele Cg
authors.initials: GC
authors.lastname: Cury
authors.forename: Rafaella Fc
authors.initials: RF
authors.lastname: Pereira
authors.forename: Gracielle A
authors.initials: GA
authors.lastname: Ferreira
authors.forename: Andreza
authors.initials: A
authors.lastname: Sousa
authors.forename: Edesia Mb
authors.initials: EM
authors.lastname: Sousa
authors.forename: Marcelo
authors.initials: M
authors.lastname: Lancellotti
mesh_terms: D016667:Bacterial Capsules / Q000235:genetics*; D009345:Neisseria meningitidis / Q000235:genetics*; D012822:Silicon Dioxide / Q000737:chemistry*; D014169:Transformation, Bacterial
chemical_list: D012822:Silicon Dioxide