title: Efficient and simple zinc-mediated synthesis of 3-amidoindoles.
abstract: A general synthesis of 3-amidoindoles from easily available arylhydrazines and acylated propargylamines is described. In the presence of inexpensive Zn salts, alkyne amination and subsequent Fischer indole-cyclization took place in good yields with excellent regioselectivity providing an interesting scaffold for potentially bio-active compounds.
authors.affiliation: Leibniz-Institut für Katalyse eV an der Universität Rostock, Rostock, Germany.
authors.forename: Anahit
authors.initials: A
authors.lastname: Pews-Davtyan
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000586:Amination; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000588:Amines; D007211:Indoles; D015032:Zinc