title: Chemical composition of the essential oil from kelussia odoratissima Mozaff. and the evaluation of its sedative and anxiolytic effects in mice.
abstract: OBJECTIVE
  The present study aimed to evaluate the sedative and anxiolytic effects of the essential oils and hydroalcoholic extract of Kelussia odoratissima Mozaff. (K. odoratissima) in mice by utilizing an elevated plus maze. The chemical composition of its essential oil was also determined.
  
  
  METHODS
  The hydroalcoholic extract or essential oil fraction from this plant were administered intraperitoneally to male mice at various doses 30 min before testing. The anxiolytic and sedative effects were determined by an elevated plus maze and locomotor activity tests, respectively.
  
  
  RESULTS
  According to the results, none of the administered doses of hydroalcoholic extract or essential oil fraction of K. odoratissima changed the percentage of the time spent or number of entries into the open arms of the elevated plus maze. In contrast, the cumulative spontaneous locomotor activity of mice treated with the essential oil or hydroalcoholic extract was significantly decreased. Chemical analysis of the essential oil by Gas chromatography-mass spectromentry (GC-MS) showed that 3-butylidene-4,5-dihydrophthalide (85.9%) was the major component.
  
  
  CONCLUSIONS
  These data confirm the sedative properties of K. odoratissima, yet there were no profound anxiolytic effects observed.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Iran. rabanim@yahoo.com
authors.forename: Mohammed
authors.initials: M
authors.lastname: Rabbani
authors.forename: Seyed Ebrahim
authors.initials: SE
authors.lastname: Sajjadi
authors.forename: Masoud
authors.initials: M
authors.lastname: Sadeghi
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy*; D019661:Apiaceae / Q000737:chemistry*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D009822:Oils, Volatile; D010936:Plant Extracts