title: [Performance by cytology and hybrid capture II in screening for high-grade squamous intraepithelial lesions in women with HIV].
abstract: HIV-infected women are at increased risk of developing high-grade squamous intraepithelial lesions (HSIL), the precursor lesions for cervical cancer. This study estimated and compared the performance of cytology and hybrid capture II in screening for precursor lesions of cervical cancer among HIV-infected women. The study population consisted of women from the open prospective cohort at the Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation (IPEC/Fiocruz). Colposcopy and histology were considered jointly in defining the gold standard. Cytology showed 31.8% sensitivity and 95.5% specificity, while hybrid capture II showed higher sensitivity (100%) and lower specificity (52%). The positive likelihood ratio was 7.1 for cytology and 2.1 for hybrid capture II, while the negative likelihood ratio was 0.7 for cytology and 0.0 for hybrid capture II.
authors.affiliation: Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
authors.forename: Letícia Martins
authors.initials: LM
authors.lastname: Raposo
authors.forename: Luciane
authors.initials: L
authors.lastname: Velasque
authors.forename: Paula Mendes
authors.initials: PM
authors.lastname: Luz
authors.forename: Ruth Khalili
authors.initials: RK
authors.lastname: Friedman
authors.forename: Andrea
authors.initials: A
authors.lastname: Cytryn
authors.forename: Angela Cristina Vasconcelos de
authors.initials: AC
authors.lastname: Andrade
authors.forename: Tazio
authors.initials: T
authors.lastname: Vanni
authors.forename: Pedro E A A
authors.initials: PE
authors.lastname: Brasil
authors.forename: Fabio
authors.initials: F
authors.lastname: Russomano
authors.forename: Valdiléa Gonçalves
authors.initials: VG
authors.lastname: Veloso
authors.forename: Beatriz
authors.initials: B
authors.lastname: Grinsztejn
authors.forename: Claudio José
authors.initials: CJ
authors.lastname: Struchiner
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D003127:Colposcopy; D003581:Cytodiagnosis; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000821:virology; D014626:Vaginal Smears / Q000379:methods; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000821:virology