title: Chlamydia pneumoniae seropositivity in adults with acute ischemic stroke: A case-control study.
abstract: BACKGROUND
  Causative role of Chlamydia pneumoniae infection in patients with acute ischemic stroke (AIS) remains unresolved till date.
  
  
  OBJECTIVE
  To investigate the role of C. pneumoniae antibodies in AIS.
  
  
  METHODS
  Patients with AIS and sex- and environment-matched controls were enrolled. Antibodies to C. pneumoniae (IgA, IgG and IgM) were measured using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  A total of 51 patients and 48 controls were enrolled. The IgA seropositivity was significantly associated with AIS (unadjusted odds ratio 3.1; 95% CI 1.38, 6.96; P = 0.005), whereas IgG (unadjusted OR 0.44; 95% CI 0.18, 1.09; P = 0.07) and IgM (unadjusted OR 1.1; 95% CI 0.36, 3.3; P = 0.88) were not. There was no difference in IgA or IgG positivity in different stroke subtypes. On multivariate analysis after adjusting for sex, hypertension, diabetes mellitus, smoking and alcohol, the IgA seropositivity yielded an adjusted OR for stroke (4.72; 95% CI 1.61, 13.83; P = 0.005), while IgG seropositivity did not (OR 0.25; 95% CI 0.08, 0.83; P = 0.23).
  
  
  CONCLUSIONS
  An increased risk of AIS was demonstrated in patients seropositive for C. pneumoniae for IgA antibodies.
authors.affiliation: Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: N K
authors.initials: NK
authors.lastname: Rai
authors.forename: R
authors.initials: R
authors.lastname: Choudhary
authors.forename: R
authors.initials: R
authors.lastname: Bhatia
authors.forename: M B
authors.initials: MB
authors.lastname: Singh
authors.forename: M
authors.initials: M
authors.lastname: Tripathi
authors.forename: K
authors.initials: K
authors.lastname: Prasad
authors.forename: M V
authors.initials: MV
authors.lastname: Padma