title: The activity of dispiro peroxides against Fasciola hepatica.
abstract: Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg.
authors.affiliation: College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Wang
authors.forename: Qingjie
authors.initials: Q
authors.lastname: Zhao
authors.forename: Mireille
authors.initials: M
authors.lastname: Vargas
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Dong
authors.forename: Kamaraj
authors.initials: K
authors.lastname: Sriraghavan
authors.forename: Jennifer
authors.initials: J
authors.lastname: Keiser
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Vennerstrom
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005210:Fasciola hepatica / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D045568:Tetraoxanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C503429:1,2,4-trioxane; D006571:Heterocyclic Compounds; D013141:Spiro Compounds; D045568:Tetraoxanes