title: Maternal serum leptin concentration in gestational diabetes.
abstract: OBJECTIVE
  The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (IGT).
  
  
  METHODS
  This case-control study, at 28 weeks of gestation, measured serum concentration of fasting leptin, insulin, and homeostatic model assessment index in three groups, GDM, IGT, and normal control, and compared them with each other.
  
  
  RESULTS
  The serum leptin level was significantly higher in women with GDM than in the two other groups (p=0.03). In women with GDM and IGT, leptin was significantly positively related with insulin and homeostatic model assessment index (r=0.221, p=0.03) and (r=0.246, p=0.03), respectively. In all of the participants, there was a significant correlation between leptin and body mass index before pregnancy (r=0.416, p=0.001).
  
  
  CONCLUSIONS
  Our data showed that serum leptin level was higher in GDM and had a positive correlation with insulin resistance. Our findings suggest that high leptin levels might be a risk factor for GDM and IGT in pregnant women.
authors.affiliation: Department of Endocrinology, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. s_soheilykhah@yahoo.com
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Soheilykhah
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Mojibian
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Rahimi-Saghand
authors.forename: Maryam
authors.initials: M
authors.lastname: Rashidi
authors.forename: Hossein
authors.initials: H
authors.lastname: Hadinedoushan
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D007328:Insulin; D020738:Leptin