title: Common variants of FTO and the risk of obesity and type 2 diabetes in Indians.
abstract: Common variants of fat mass and obesity-associated gene (FTO, fat mass- and obesity-associated gene) have been shown to be associated with obesity and type 2 diabetes in population of European and non-European ethnicity. However, studies in Indian population have provided inconsistent results. Here, we examined association of eight FTO variants (rs1421085, rs8050136, rs9939609, rs9930506, rs1861867, rs9926180, rs2540769 and rs708277) with obesity and type 2 diabetes in 5364 North Indians (2474 type 2 diabetes patients and 2890 non-diabetic controls) in two stages. None of the variants including previously reported intron 1 variants (rs1421085, rs8050136, rs9939609 and rs9930506) showed body mass index (BMI)-dependent/independent association with type 2 diabetes. However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population. Meta-analysis of the two study population results also revealed that rs1421085, rs8050136 and rs9939609 were significantly associated with BMI both under the random- and fixed-effect models (P (random/fixed)=0.02/0.0001, 0.004/0.0006 and 0.01/0.01, respectively). In conclusion, common variants of FTO were associated with obesity, but not with type 2 diabetes in North Indian population.
authors.affiliation: Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (CSIR), Delhi, India.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Chauhan
authors.forename: Rubina
authors.initials: R
authors.lastname: Tabassum
authors.forename: Anubha
authors.initials: A
authors.lastname: Mahajan
authors.forename: Om Prakash
authors.initials: OP
authors.lastname: Dwivedi
authors.forename: Yuvaraj
authors.initials: Y
authors.lastname: Mahendran
authors.forename: Ismeet
authors.initials: I
authors.lastname: Kaur
authors.forename: Shubhanchi
authors.initials: S
authors.lastname: Nigam
authors.forename: Himanshu
authors.initials: H
authors.lastname: Dubey
authors.forename: Binuja
authors.initials: B
authors.lastname: Varma
authors.forename: Sri Venkata
authors.initials: SV
authors.lastname: Madhu
authors.forename: Sandeep K
authors.initials: SK
authors.lastname: Mathur
authors.forename: Saurabh
authors.initials: S
authors.lastname: Ghosh
authors.forename: Nikhil
authors.initials: N
authors.lastname: Tandon
authors.forename: Dwaipayan
authors.initials: D
authors.lastname: Bharadwaj
mesh_terms: D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human