title: Effects of sildenafil on the viability of random skin flaps.
abstract: OBJECTIVE
  To assess the viability of McFarlane skin flaps in rats with administration of sildenafil.
  
  
  METHODS
  Twenty Wistar rats were distributed into two groups: Control (dorsal skin flap, subdermal application of saline solution at 0.9%) and Study (dorsal skin flap, subdermal application of sildenafil). Seven days after the surgery, flaps were photographed and graphically rendered. Then, they were analyzed with AutoCAD software. Three biopsies (proximal, medial and distal) of each flap were collected for histological analysis.
  
  
  RESULTS
  Macroscopic analysis showed that animals of the study group had greater necrotic areas (p=0.003) in the dorsal skin flaps. Additionally, histological analysis of the distal third of these flaps showed a tendency to less granulated tissue formation in animals treated with sildenafil.
  
  
  CONCLUSIONS
  Sildenafil subdermally was associated with lower viability of the random skin flap in rats.
authors.affiliation: Department of Surgery, UFMG, Belo Horizonte, MG, Brazil. sumara@terra.com.br
authors.forename: Sumara Marques
authors.initials: SM
authors.lastname: Barral
authors.forename: Ivana Duval
authors.initials: ID
authors.lastname: Araujo
authors.forename: Paula Vieira Teixeira
authors.initials: PV
authors.lastname: Vidigal
authors.forename: Cláudio Alvarenga Campos
authors.initials: CA
authors.lastname: Mayrink
authors.forename: Adriana Duval
authors.initials: AD
authors.lastname: Araujo
authors.forename: Paulo Roberto da
authors.initials: PR
authors.lastname: Costa
mesh_terms: D000818:Animals; D001706:Biopsy; D062109:Dermatologic Surgical Procedures; D005260:Female; D009336:Necrosis / Q000473:pathology; D058986:Phosphodiesterase 5 Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000068677:Sildenafil Citrate; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013450:Sulfones / Q000494:pharmacology*; D013524:Surgical Flaps / Q000473:pathology*; D014022:Tissue Survival / Q000187:drug effects*; D014945:Wound Healing
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate