title: TFEB regulates autophagy: an integrated coordination of cellular degradation and recycling processes.
abstract: Autophagy is a fundamental catabolic process that plays a central role in health and disease. An efficient autophagic process relies on the cooperation of two distinct types of organelles: the autophagosome and the lysosome. We have identified a gene network that regulates the biogenesis and function of both organelles. Our findings reveal an important role of transcription in the regulation of starvation-induced autophagy, and link lysosomal biogenesis to autophagy.
authors.affiliation: Telethon Institute of Genetics and Medicine, Naples, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Settembre
authors.forename: Andrea
authors.initials: A
authors.lastname: Ballabio
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics*; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism*; D053263:Gene Regulatory Networks / Q000235:genetics*; D008247:Lysosomes / Q000378:metabolism; D051379:Mice; D008954:Models, Biological
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors