title: Maternal and fetal circulation of unusual bile acids: a pilot study.
abstract: BACKGROUND
  Large amounts of unusual bile acids are synthesized by the fetal liver in late gestation. These compounds are mostly transferred from fetus to mother, although some are excreted into the amniotic fluid. We investigated the role of placental transfer of bile acids in fetal bile acid metabolism, particularly with respect to the unusual bile acids (1β-hydroxylated and ketonic bile acids).
  
  
  METHODS
  We measured concentrations of bile acids in umbilical cord blood and urine of newborn infants, and in perinatal maternal serum and urine, using gas chromatography-mass spectrometry. Serum and urine specimens from healthy non-pregnant women were used as controls.
  
  
  RESULTS
  In newborn infants at delivery, cord blood and urine contained mostly primary and 1β-hydroxylated bile acids, respectively. We also detected large amounts of ketonic bile acids in their urine, and the urinary concentration of total bile acids was elevated. Main maternal bile acids at 30 and 35 weeks of gestation and at delivery were 1β-hydroxylated bile acids. After delivery, main bile acids changed from 1β-hydroxylated bile acids to primary bile acids (P < 0.03), which also predominated in healthy non-pregnant women.
  
  
  CONCLUSIONS
  Fetally synthesized unusual bile acids were transported from fetus to mother. Pregnant women appear to excrete these bile acids into the urine, lowering both fetal and maternal serum bile acid concentrations.
authors.affiliation: Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Seki
authors.forename: Masami
authors.initials: M
authors.lastname: Matsushita
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishiura
authors.forename: Kumiko
authors.initials: K
authors.lastname: Aoki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Inokuchi
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Mizuochi
authors.forename: Takao
authors.initials: T
authors.lastname: Kurosawa
authors.forename: Yukuo
authors.initials: Y
authors.lastname: Kimura
authors.forename: Toyojiro
authors.initials: T
authors.lastname: Matsuishi
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism*; D001692:Biological Transport; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism; D005500:Follow-Up Studies; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010865:Pilot Projects; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D001647:Bile Acids and Salts