title: Neutral desorption extractive electrospray ionization mass spectrometry for fast screening sunscreen agents in cream cosmetic products.
abstract: High throughput analysis of sunscreen agents present in cream cosmetic has been demonstrated, typically 2 samples per minute, using neutral desorption extractive electrospray ionization mass spectrometry (ND-EESI-MS) without sample pretreatment. For the targeted compounds such as 4-Aminobenzoic acid and oxybenzone, ND-EESI-MS method provided linear signal responses in the range of 1-100 ppb. Limits of detection (LOD) of the method were estimated at sub-ppb levels for the analytes tested. Reasonable relative standard deviation (RSD=8.4-16.0%) was obtained as a result of 10 independent measurements for commercial cosmetics samples spiked with each individual sunscreen agents at 1-10 ppb. Acceptable recoveries were achieved in the range of 87-116% for direct analysis of commercial cream cosmetic samples. The experimental data demonstrate that ND-EESI-MS is a useful tool for high throughput screening of sunscreen agents in highly viscous cream cosmetic products, with the capability to obtain quantitative information of the analytes.
authors.affiliation: Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China Institute of Technology, Nanchang, Jiangxi Province, PR China.
authors.forename: Xinglei
authors.initials: X
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Jinghua
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Hu
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.forename: Liying
authors.initials: L
authors.lastname: Ding
authors.forename: Li
authors.initials: L
authors.lastname: Jia
authors.forename: Huanwen
authors.initials: H
authors.lastname: Chen
mesh_terms: D010129:4-Aminobenzoic Acid / Q000032:analysis; D001577:Benzophenones / Q000032:analysis; D003358:Cosmetics / Q000737:chemistry*; D004643:Emollients / Q000737:chemistry*; D015203:Reproducibility of Results; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation / Q000379:methods*; D013473:Sunscreening Agents / Q000032:analysis*
chemical_list: D001577:Benzophenones; D003358:Cosmetics; D004643:Emollients; D013473:Sunscreening Agents; C005290:oxybenzone; D010129:4-Aminobenzoic Acid