title: Transmission of two distinct HIV type 1 strains to an individual that were harbored for many years by another.
abstract: The concept of transmission bottlenecks in HIV-1 infection is well established. Coinfections and superinfections have been increasingly documented and provide a founding cause for the expansion of viral diversity through recombination. It is still relatively unclear how HIV-1 will propagate and evolve in individuals infected with more than one viral strain. Here we report on the parallel transmission of genetically distant viral strains cocirculating in one individual over many years to a single recipient.
authors.affiliation: Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, The Netherlands.
authors.forename: Maaike B
authors.initials: MB
authors.lastname: van Werkhoven
authors.forename: Elly
authors.initials: E
authors.lastname: Baan
authors.forename: Margreet
authors.initials: M
authors.lastname: Bakker
authors.forename: Suzanne
authors.initials: S
authors.lastname: Jurriaans
authors.forename: William A
authors.initials: WA
authors.lastname: Paxton
authors.forename: Georgios
authors.initials: G
authors.lastname: Pollakis
mesh_terms: D006679:HIV Seropositivity / Q000235:genetics / Q000635:transmission*; D015497:HIV-1 / Q000235:genetics; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic
chemical_list: D012367:RNA, Viral