title: Rational approach to treatment options for Lennox-Gastaut syndrome.
abstract: Lennox-Gastaut syndrome (LGS) is an intractable childhood-onset epileptic encephalopathy. Seizure freedom is rare in LGS. One of the hallmarks of LGS is medical intractability, with generally poor response to antiepileptic drugs (AEDs). Nevertheless, several treatment options are available that can mitigate the severity of seizures and curtail their frequency. New AEDs have been validated in randomized, controlled trials for the treatment of seizures in LGS. In some cases, nonpharmacologic options may be effective, although more data are needed to confirm efficacy outcomes. Comprehensive patient assessments are critical to achieve an optimal AED treatment regimen and minimize the potential for adverse effects.
authors.affiliation: Department of Neurology, Boston University School of Medicine, Boston Medical Center, 72 East Concord Street, Boston, MA 02118-3294, U.S.A. georgia.montouris@bmc.org
authors.forename: Georgia D
authors.initials: GD
authors.lastname: Montouris
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D018849:Controlled Clinical Trials as Topic / Q000706:statistics & numerical data; D003337:Corpus Callosum / Q000601:surgery; D055423:Diet, Ketogenic; D004334:Drug Administration Schedule; D004599:Electric Stimulation Therapy; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D065768:Lennox Gastaut Syndrome; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data; D013036:Spasms, Infantile / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome; D055536:Vagus Nerve Stimulation
chemical_list: D000927:Anticonvulsants