title: Safety, immunogenicity and kinetics of immune response to 7-valent pneumococcal conjugate vaccine in children with idiopathic nephrotic syndrome.
abstract: Safety, immunogenicity and kinetics of 7-valent pneumococcal-conjugate vaccine (PCV7) immune response were evaluated in 33 children with idiopathic nephrotic syndrome (INS) and 16 controls. PCV7 was not associated with increased risk of relapse (RR=0.80, p=0.61). Serotype (PS)-specific antibodies increased in all subjects at 1 month (p<0.01) with inferior immunogenicity for 3/7 PS in patients on immunomodulators (p<0.02). Most patients retained protective antibodies at 12-14 months although at lower levels for 4/7 PS (p<0.08). Different PS kinetics in INS suggests antibody monitoring and revaccination when necessary for protection from pneumococcal infections.
authors.affiliation: 1st Department of Pediatrics, Division of Infectious Diseases, Aghia Sophia Children's Hospital, Athens University School of Medicine, Athens, Greece.
authors.forename: Christina D
authors.initials: CD
authors.lastname: Liakou
authors.forename: Varvara
authors.initials: V
authors.lastname: Askiti
authors.forename: Andromachi
authors.initials: A
authors.lastname: Mitsioni
authors.forename: Constantinos J
authors.initials: CJ
authors.lastname: Stefanidis
authors.forename: Maria C
authors.initials: MC
authors.lastname: Theodoridou
authors.forename: Vana I
authors.initials: VI
authors.lastname: Spoulou
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000276:immunology; D002648:Child; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary / Q000379:methods; D008297:Male; D009402:Nephrosis, Lipoid / Q000276:immunology* / Q000378:metabolism; D011008:Pneumococcal Infections / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology / Q000493:pharmacokinetics; D011446:Prospective Studies; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate