title: [Biological properties of a prolonged action interferon inductor].
abstract: OBJECTIVE
  Evaluation of composite formulation of yeast double stranded RNA with polyglucinum (dsRNA-PG) effect on non-specific antiviral resistance factors in mice in comparison with commercial formulation Ridostin.
  
  
  METHODS
  dsRNA and Ridostin formulations were injected intramuscularly once at the dose of 5 mg/ml, polyglucinum--at the dose of 3.75 mg/ml. 3, 5, 24, 48 and 72 hours after the injection serum interferon levels, neutrophil oxidation-reduction activity parameters, peritoneal macrophage phagocyte activity levels were analyzed in mice blood samples.
  
  
  RESULTS
  New dsRNA and polyglucinum containing composite formulation is a non-specific resistance system stimulator. dsRNA-PG effect on interferon synthesis and mice phagocyte activity was higher than with Ridostin and developed earlier. Neutrophil function activation by the formulation had a prolonged effect. A possible explanation for increased activity of dsRNA and polyglucinum composite formulation is a modulating effect by the polysaccharide component.
  
  
  CONCLUSIONS
  The new formulation may have a more intensive and prolonged protective effect against influenza virus in comparison with Ridostin.
authors.forename: E D
authors.initials: ED
authors.lastname: Danilenko
authors.forename: S G
authors.initials: SG
authors.lastname: Gamaleĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Bateneva
authors.forename: G M
authors.initials: GM
authors.lastname: Sysoeva
authors.forename: G M
authors.initials: GM
authors.lastname: Levagina
authors.forename: V I
authors.initials: VI
authors.lastname: Masycheva
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D003911:Dextrans / Q000008:administration & dosage*; D007369:Interferon Inducers / Q000008:administration & dosage*; D007372:Interferons / Q000097:blood*; D051379:Mice; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D009975:Orthomyxoviridae / Q000187:drug effects; D012330:RNA, Double-Stranded / Q000008:administration & dosage*; D012331:RNA, Fungal / Q000008:administration & dosage
chemical_list: D000998:Antiviral Agents; D003911:Dextrans; D007369:Interferon Inducers; C560778:Polyglucinum; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; C076741:ridostin; D007372:Interferons