title: Regulatory T cells in stem cell transplantation: strategies and first clinical experiences.
abstract: The adoptive transfer of donor-type CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) protects from graft-versus-host disease in murine bone marrow transplantation models. Results from first clinical trials exploring such strategies have recently been presented and seem to confirm the efficacy of Treg for the prevention of this severe complication after allogeneic stem cell transplantation. Further improvements in Treg isolation and in vitro expansion technologies will facilitate the broader exploration of Treg therapies, for example, for the treatment of ongoing graft-versus-host disease or the prevention of graft rejection after solid organ transplantation.
authors.affiliation: Department of Hematology and Oncology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. matthias.edinger@klinik.uni-regensburg.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Edinger
authors.forename: Petra
authors.initials: P
authors.lastname: Hoffmann
mesh_terms: D056704:Adaptive Immunity; D019264:Adoptive Transfer / Q000379:methods*; D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D016026:Bone Marrow Transplantation; D049109:Cell Proliferation; D002986:Clinical Trials as Topic; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology*; D006086:Graft vs Host Disease / Q000276:immunology / Q000517:prevention & control*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D017710:Lymphocyte Transfusion / Q000379:methods*; D051379:Mice; D018345:Mice, Knockout; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: D015703:Antigens, CD; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse