title: Determinants of serum polybrominated diphenyl ether (PBDE) levels among pregnant women in the CHAMACOS cohort.
abstract: We measured levels of 10 polybrominated diphenyl ether (PBDE) congeners in serum collected during pregnancy and at delivery from 416 pregnant, predominantly immigrant, women living in Monterey County, CA. The most frequently detected congeners were BDE-47, -99, -100, and -153, all components of the penta mixture, detected in >97% of samples. We used multivariable regression models to examine factors associated with exposure to individual PBDE congeners as well as their total summed concentration (ng/g lipid). Prenatal and delivery total PBDE levels were correlated between sampling times (n = 21; Pearson r = 0.99, p < 0.001). In multivariable models, total PBDE levels increased significantly with time residing in the U.S. (p < 0.001) and among women with ≥3 pieces of stuffed furniture in their homes (p < 0.05). Women's total PBDE levels increased 4.0% (95% CI = 2.8, 5.3) for each additional year residing in the U.S., after adjustment for prepregnancy BMI, weight gain during pregnancy, and SES. Having ≥3 pieces of stuffed furniture in the home was associated with a 26.8% (95% CI = 2.0, 57.5) increase in women's serum PBDE levels. Findings suggest PBDE indoor contamination in California homes is contributing to human exposures in a population of recent immigrants.
authors.affiliation: Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California, United States. rcastori@berkeley.edu
authors.forename: Rosemary
authors.initials: R
authors.lastname: Castorina
authors.forename: Asa
authors.initials: A
authors.lastname: Bradman
authors.forename: Andreas
authors.initials: A
authors.lastname: Sjödin
authors.forename: Laura
authors.initials: L
authors.lastname: Fenster
authors.forename: Richard S
authors.initials: RS
authors.lastname: Jones
authors.forename: Kim G
authors.initials: KG
authors.lastname: Harley
authors.forename: Ellen A
authors.initials: EA
authors.lastname: Eisen
authors.forename: Brenda
authors.initials: B
authors.lastname: Eskenazi
mesh_terms: D000328:Adult; D002140:California; D002648:Child; D015331:Cohort Studies; D003710:Demography; D004032:Diet; D004784:Environmental Monitoring; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000097:blood*; D006798:Housing; D006801:Humans; D016014:Linear Models; D018811:Maternal Exposure; D020380:Needs Assessment; D011247:Pregnancy
chemical_list: D055768:Halogenated Diphenyl Ethers