title: [Anti-transglutaminase, antigladin and ultra purified anti-gladin antibodies in patients with a diagnosis of rheumatoid arthritis].
abstract: Celiac disease (CD) is an enteric disease caused by dietary gluten in individuals with genetic predisposition. One of the clinical manifestations of CD is the peripheral arthritis that may simulate RA.
  
  
  OBJECTIVE
  To determine the frequency of anti-gliadin (aGL), anti-tissue transglutaminase (aTGT) and ultra purified anti-gliadin (AGLU) antibodies in patients with RA.
  
  
  METHODS
  Cross-sectional study. We included consecutive patients diagnosed as RA (ACR). Demographic and clinical data was registered by direct interview and serum levels of aGL, aTGT y aGLU were determined using ELISA.
  
  
  RESULTS
  Eighty-five RA patients were included; 87% were women. Mean age was 44±12 years, mean disease duration 12 ±9 years. aGL IgG antibodies were positive in 16 patients, IgA aGL antibodies in 29 patients, aGLU in 14 patients and only one patient had aTGT.
  
  
  CONCLUSIONS
  It is possible that CD may be the correct diagnosis in a patient with polyarthritis, even if the patient meets the ACR criteria for RA. In other words, CD should be considered among the differential diagnoses in a patient with poly-arthritis.
authors.affiliation: Hospital de Especialidades, UMAE Centro Médico Nacional de Occidente del Instituto Mexicano del Seguro Social, Guadalajara, México.
authors.forename: José Dionisio
authors.initials: JD
authors.lastname: Castillo-Ortiz
authors.forename: Sergio
authors.initials: S
authors.lastname: Durán-Barragán
authors.forename: Adriana
authors.initials: A
authors.lastname: Sánchez-Ortíz
authors.forename: Cesar
authors.initials: C
authors.lastname: Ramos-Remus
mesh_terms: D000328:Adult; D000368:Aged; D000918:Antibody Specificity; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D002446:Celiac Disease / Q000175:diagnosis* / Q000276:immunology; D003430:Cross-Sectional Studies; D057210:Delayed Diagnosis; D003951:Diagnostic Errors; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019204:GTP-Binding Proteins / Q000276:immunology*; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000276:immunology*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D005903:Gliadin; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins