title: Comparative study on the chemical composition, antioxidant properties and hypoglycaemic activities of two Capsicum annuum L. cultivars (Acuminatum small and Cerasiferum).
abstract: The present study aimed to evaluate for the first time the phenols, flavonoids, carotenoids, capsaicin and dihydrocapsaicin content and the antioxidant and hypoglycemic properties of Capsicum annuum var. acuminatum small and C. annuum var. cerasiferum air-dried fruits. The ethanol extract of C. annuum var. acuminatum small, characterized by the major content of total poliphenols, flavonoids, carotenoids and capsaicinoids, showed the highest radical scavenging activity (IC(50) of 152.9 μg/ml). On the contrary, C. annuum var. cerasiferum showed a significant antioxidant activity evaluated by the β-carotene bleaching test (IC(50) of 3.1 μg/ml). The lipophilic fraction of both C. annuum var. acuminatum and C. annuum var. cerasiferum exhibited an interesting and selective inhibitory activity against α-amylase (IC(50) of 6.9 and 20.1 μg/ml, respectively).
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Rende, CS, Italy. tundis@unical.it
authors.forename: Rosa
authors.initials: R
authors.lastname: Tundis
authors.forename: Monica R
authors.initials: MR
authors.lastname: Loizzo
authors.forename: Federica
authors.initials: F
authors.lastname: Menichini
authors.forename: Marco
authors.initials: M
authors.lastname: Bonesi
authors.forename: Filomena
authors.initials: F
authors.lastname: Conforti
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Statti
authors.forename: Damiano
authors.initials: D
authors.lastname: De Luca
authors.forename: Bruno
authors.initials: B
authors.lastname: de Cindio
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichini
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis* / Q000494:pharmacology; D002211:Capsaicin / Q000032:analysis; D002212:Capsicum / Q000737:chemistry* / Q000145:classification; D002338:Carotenoids / Q000032:analysis; D004791:Enzyme Inhibitors / Q000032:analysis* / Q000494:pharmacology; D005419:Flavonoids / Q000032:analysis; D005638:Fruit / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000032:analysis* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D010636:Phenols / Q000032:analysis; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D013552:Swine; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D005419:Flavonoids; D007004:Hypoglycemic Agents; D010636:Phenols; D010936:Plant Extracts; D002338:Carotenoids; D000516:alpha-Amylases; D002211:Capsaicin