title: Pathological study for the effects of in utero and postnatal exposure to diesel exhaust on a rat endometriosis model.
abstract: Previous studies have shown that prenatal and postnatal exposure to diesel exhaust (DE), which is known to be one of the main constituents of air pollution, enhances the persistence of endometriosis in a rat model. The aim of this study is to investigate the pathological changes induced by DE exposure in a rat model of endometriosis. Pregnant Sprague-Dawley rats were exposed to DE or clean air beginning on gestational day 2 and neonatal rats were persistently exposed to DE or clean air. Endometriosis was induced by autotransplantation of endometrium onto the peritoneum of eight-week-old female offspring. Endometriotic lesions were examined at 7 and 14 days post-transplantation. As a result, infiltration of activated mast cells remained in deeper area of peritoneal tissue around the endometriosis model compared to the control group at 14 days post-autotransplantation. In the DE exposure group, 14 days post-transplant, the remaining lesions contained fibroblasts and activated mast cells, which were surrounded by collagen fibers. The data showed that prenatal and postnatal DE exposure enhances the activation of mast cells and prolongs the persistence of collagen fibers in the induced rat model of endometriosis.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Umezawa
authors.forename: Chika
authors.initials: C
authors.lastname: Sakata
authors.forename: Naomi
authors.initials: N
authors.lastname: Tanaka
authors.forename: Masako
authors.initials: M
authors.lastname: Tabata
authors.forename: Ken
authors.initials: K
authors.lastname: Takeda
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ihara
authors.forename: Masao
authors.initials: M
authors.lastname: Sugamata
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D004715:Endometriosis / Q000139:chemically induced* / Q000473:pathology*; D004717:Endometrium / Q000187:drug effects / Q000637:transplantation / Q000648:ultrastructure; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D005865:Gestational Age; D008407:Mast Cells / Q000187:drug effects / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D010537:Peritoneum / Q000648:ultrastructure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000473:pathology*; D051381:Rats; D012744:Sex Ratio; D014182:Transplantation, Autologous; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D001335:Vehicle Emissions