title: Electrophysiological auditory responses and language development in infants with periventricular leukomalacia.
abstract: This study presents evidence suggesting that electrophysiological responses to language-related auditory stimuli recorded at 46weeks postconceptional age (PCA) are associated with language development, particularly in infants with periventricular leukomalacia (PVL). In order to investigate this hypothesis, electrophysiological responses to a set of auditory stimuli consisting of series of syllables and tones were recorded from a population of infants with PVL at 46weeks PCA. A communicative development inventory (i.e., parent report) was applied to this population during a follow-up study performed at 14months of age. The results of this later test were analyzed with a statistical clustering procedure, which resulted in two well-defined groups identified as the high-score (HS) and low-score (LS) groups. The event-induced power of the EEG data recorded at 46weeks PCA was analyzed using a dimensionality reduction approach, resulting in a new set of descriptive variables. The LS and HS groups formed well-separated clusters in the space spanned by these descriptive variables, which can therefore be used to predict whether a new subject will belong to either of these groups. A predictive classification rate of 80% was obtained by using a linear classifier that was trained with a leave-one-out cross-validation technique.
authors.affiliation: Unidad de Investigación en Neurodesarrollo, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, 76230 Querétaro, Mexico.
authors.forename: G N
authors.initials: GN
authors.lastname: Avecilla-Ramírez
authors.forename: S
authors.initials: S
authors.lastname: Ruiz-Correa
authors.forename: J L
authors.initials: JL
authors.lastname: Marroquin
authors.forename: T
authors.initials: T
authors.lastname: Harmony
authors.forename: A
authors.initials: A
authors.lastname: Alba
authors.forename: O
authors.initials: O
authors.lastname: Mendoza-Montoya
mesh_terms: D001307:Auditory Perception; D042241:Early Diagnosis; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007804:Language Development; D007805:Language Development Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D007969:Leukomalacia, Periventricular / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male