title: Autoimmune thrombocytopenic purpura in partial DiGeorge syndrome: case presentation.
abstract: The absence of an appropriate central tolerance in primary immunodeficiencies favors proliferation of autoreactive lymphocyte clones, causing a greater incidence of autoimmunity. Del 22q11.2 syndrome presents an increased incidence of allergic and autoimmune diseases. One of the most relevant and frequent immune manifestations is autoimmune thrombocytopenia. We present the case of a pediatric patient with autoimmune thrombocytopenia due to the immunological dysregulation observed in partial DiGeorge syndrome.
authors.affiliation: Department of Immunology, Instituto Nacional de Pediatria, Mexico City, Mexico.
authors.forename: Leticia
authors.initials: L
authors.lastname: Hernández-Nieto
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Yamazaki-Nakashimada
authors.forename: Esther
authors.initials: E
authors.lastname: Lieberman-Hernández
authors.forename: Sara Elva
authors.initials: SE
authors.lastname: Espinosa-Padilla
mesh_terms: D000293:Adolescent; D002872:Chromosome Deletion; D004062:DiGeorge Syndrome / Q000150:complications* / Q000276:immunology*; D005260:Female; D006801:Humans; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology*