title: Clinical characteristics of fulminant type 1 diabetes associated with pregnancy in China.
abstract: To report 12 cases of pregnancy-associated fulminant type 1 diabetes mellitus (PF) found in China from 2003 to 2010. The clinical and biochemical characteristics of these cases with PF were compared with a group of cases of child-bearing age with fulminant type 1 diabetes that was not associated with pregnancy (NPF). The clinical and biochemical characteristics of 12 PF cases were analyzed retrospectively and then compared with those characteristics of 20 NPF cases in China. The difference between Chinese and Japanese PF cases was investigated. The mean values of the characteristics from PF and NPF cases in China, including postprandial serum C-peptide concentration, plasma glucose concentration, and serum chloride were different. Compared to the 22 PF cases in Japan, the mean age of these 12 PF cases was much younger. The mean fasting and postprandial serum C-peptide concentration level were lower, and the mean HbA1c levels was higher in 12 PF cases in China. Eight of 12 PF cases in China developed  the disease during pregnancy. Other four PF case developed the disease within 2 weeks after delivery. 12 PF cases in China showed more severe beta-cell destruction, the prognosis of their fetuses was extremely poor.
authors.affiliation: Department of Endocrinology, Affiliated Futian Hospital of Guangdong Medical College, Shennan zhong Road, Shenzhen, 518033, China. liul2005@hotmail.com
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
authors.forename: Jiping
authors.initials: J
authors.lastname: Mao
authors.forename: Zeyuan
authors.initials: Z
authors.lastname: Lu
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Yan
authors.forename: Xiaosu
authors.initials: X
authors.lastname: Bai
authors.forename: Yiyi
authors.initials: Y
authors.lastname: Ye
authors.forename: Gang
authors.initials: G
authors.lastname: Zou
mesh_terms: D000138:Acidosis / Q000097:blood; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001786:Blood Glucose / Q000502:physiology*; D002096:C-Peptide / Q000097:blood; D002681:China / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000145:classification / Q000453:epidemiology* / Q000276:immunology; D016640:Diabetes, Gestational / Q000097:blood / Q000145:classification / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D006442:Glycated Hemoglobin