title: Diagnostic utility of combination of inducer and inhibitor based assay in detection of Pseudomonas aeruginosa producing AmpC β-lactamase.
abstract: The diagnostic utility of inducer and inhibitor based assays among 214 AmpC positive isolates of Pseudomonas aeruginosa were evaluated. Of different methods, combination of ceftazidime-imipenem antagonism and boronic acid inhibition tests came up with maximum sensitivity (76%) and specificity (100%). This combination showed reliability for both inducible and non-inducible AmpC producers.
authors.affiliation: Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
authors.forename: Supriya
authors.initials: S
authors.lastname: Upadhyay
authors.forename: Malay Ranjan
authors.initials: MR
authors.lastname: Sen
authors.forename: Amitabha
authors.initials: A
authors.lastname: Bhattacharjee
authors.forename: Pradyot
authors.initials: P
authors.lastname: Prakash
authors.forename: Ram Chandra
authors.initials: RC
authors.lastname: Bajpai
authors.forename: Shampa
authors.initials: S
authors.lastname: Anupurba
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001897:Boronic Acids / Q000494:pharmacology*; D003023:Cloxacillin / Q000494:pharmacology*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000145:classification* / Q000187:drug effects / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001897:Boronic Acids; C048795:AmpC beta-lactamases; D001618:beta-Lactamases; D003023:Cloxacillin