title: Virilizing ovarian Krukenberg tumor in a 27-year-old pregnant woman. A case report and literature review.
abstract: A case is reported of a 27-year-old pregnant woman with ovarian tumors, measuring 12 cm and 11.5 cm in the greatest diameter, discovered during investigation for virilization symptoms. Termination of the pregnancy at the 22nd week of gestation and tumorectomy with both adnexa were performed, with the provisional diagnosis of arrhenoblastoma. Pathological examination of the tumors showed typical Krukenberg neoplasms and subsequent upper GI tract endoscopy revealed a gastric cancer that was excised. The pathological examination revealed a diffuse type gastric adenocarcinoma with signet ring morphology, similar to ovarian tumors. In any case of ovarian tumor with unusual hormonal manifestations, in addition to hormonally active sex cord-stromal neoplasms, metastatic ovarian tumors must be considered as well, especially in cases of bilateral tumors.
authors.affiliation: Pathology Laboratory, Aretaieion University Hospital, Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Papakonstantinou
authors.forename: A
authors.initials: A
authors.lastname: Liapis
authors.forename: E
authors.initials: E
authors.lastname: Kairi-Vassilatou
authors.forename: C
authors.initials: C
authors.lastname: Iavazzo
authors.forename: C K
authors.initials: CK
authors.lastname: Kleanthis
authors.forename: A
authors.initials: A
authors.lastname: Kondi-Pafiti
mesh_terms: D000032:Abortion, Therapeutic; D000328:Adult; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007725:Krukenberg Tumor / Q000150:complications / Q000556:secondary* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000150:complications / Q000556:secondary* / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000601:surgery; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D014770:Virilism / Q000209:etiology* / Q000473:pathology / Q000601:surgery