title: [Frequency of systemic manifestations in patients with primary Sjögren's syndrome in Argentina].
abstract: Twenty to 71% of patients with Sjögren's syndrome (SS) will develop systemic manifestations.
  
  
  OBJECTIVE
  To characterize the clinical-serological presentation and the frequency of systemic manifestations in patients with primary SS.
  
  
  METHODS
  Retrospective study including patients with SS visited in "Hospital Británico de Buenos Aires" during the period from January 2000 to August 2008.
  
  
  RESULTS
  Forty-one patients fulfilled the 2002 American-European classification criteria for SS. All patients were women. Mean age at enrollment was 57.85 ± 12.42 years (range 26-79). Mean duration of the disease was 9.28 years (range 0.08-24). Thirty-three (80.49%) developed systemic manifestations. The most frequent were arthritis, cutaneous vasculitis and polyneuropathy. This group featured more frequently ANA titles ≥ 1/640 and hypocomplementemia; although no statistical significance was found. The frequency of systemic manifestations found was greater than reported in the literature.
  
  
  CONCLUSIONS
  A multidisciplinary approach focusing also on systemic manifestations should be the new standard for management of SS.
authors.affiliation: Servicio de Reumatología, Buenos Aires, Argentina. reumatologia@hbritanico.com.ar
authors.forename: Federico
authors.initials: F
authors.lastname: Zazzetti
authors.forename: Mariano Adolfo
authors.initials: MA
authors.lastname: Rivero
authors.forename: Damián Elvio
authors.initials: DE
authors.lastname: Duartes Noé
authors.forename: Alberto
authors.initials: A
authors.lastname: Gallacher
authors.forename: Amalia
authors.initials: A
authors.lastname: Schiel
authors.forename: Marina Claudia
authors.initials: MC
authors.lastname: Khoury
authors.forename: Hugo Armando
authors.initials: HA
authors.lastname: Laborde
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Barreira