title: Antidepressant-like activity of 10-hydroxy-trans-2-decenoic Acid, a unique unsaturated Fatty Acid of royal jelly, in stress-inducible depression-like mouse model.
abstract: Symptoms of depression and anxiety appeared in mice after they had been subjected to a combination of forced swimming for 15 min followed by being kept in cages that were sequentially subjected to leaning, drenching, and rotation within 1-2 days for a total of 3 weeks. The animals were then evaluated by the tail-suspension test, elevated plus-maze test, and open-field test at 1 day after the end of stress exposure. Using these experimental systems, we found that 10-hydroxy-trans-2-decenoic acid (HDEA), an unsaturated fatty acid unique to royal jelly (RJ), protected against the depression and anxiety when intraperitoneally administered once a day for 3 weeks simultaneously with the stress loading. Intraperitoneally administered RJ, a rich source of HDEA, was also protective against the depression, but RJ given by the oral route was less effective. Our present results demonstrate that HDEA and RJ, a natural source of it, were effective in ameliorating the stress-inducible symptoms of depression and anxiety.
authors.affiliation: Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigaku-nishi Gifu 501-1196, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Ito
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nitta
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Fukumitsu
authors.forename: Hitomi
authors.initials: H
authors.lastname: Soumiya
authors.forename: Kumiko
authors.initials: K
authors.lastname: Ikeno
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Shoei
authors.initials: S
authors.lastname: Furukawa