title: Emerging application of stereotactic body radiation therapy for gynecologic malignancies.
abstract: Stereotactic body radiation therapy (SBRT) involves delivery of image-guided, ablative radiation doses to planning treatment volume(s) using sophisticated dosimetric planning and target localization. Early on, clinical investigators pursued SBRT for the treatment of early stage non-small-cell lung cancer, lung and liver oligometastases and spinal metastases. As a result of its clinical efficacy in these disease sites, SBRT has been explored in the management of persistent or recurrent gynecological cancers. This article will consider indications for SBRT application in gynecological cancer management, will reflect on outcomes from key SBRT clinical trials and will discuss new therapeutic roles of SBRT for gynecological cancers.
authors.affiliation: Arthur G James Cancer Hospital and Solove Research Institute Ohio State University, OH, USA.
authors.forename: Nina A
authors.initials: NA
authors.lastname: Mayr
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Huang
authors.forename: Jason W
authors.initials: JW
authors.lastname: Sohn
authors.forename: Simon S
authors.initials: SS
authors.lastname: Lo
authors.forename: Bin S
authors.initials: BS
authors.lastname: Teh
authors.forename: Jiade J
authors.initials: JJ
authors.lastname: Lu
authors.forename: John C
authors.initials: JC
authors.lastname: Grecula
authors.forename: Charles
authors.initials: C
authors.lastname: Kunos
mesh_terms: D002986:Clinical Trials as Topic; D018450:Disease Progression; D005260:Female; D005833:Genital Neoplasms, Female / Q000601:surgery* / Q000628:therapy; D006801:Humans; D016634:Radiosurgery / Q000379:methods / Q000706:statistics & numerical data*; D013997:Time Factors