title: Biomarker explorations in acute kidney injury: the journey continues.
abstract: Determining whether an elevation in serum creatinine represents structural damage or a reversible functional change is a dilemma that clinicians encounter frequently. The emergence of kidney-specific biomarkers offers an opportunity to improve our discriminatory ability. Singer et al. provide new information on the utility of neutrophil gelatinase-associated lipocalin (NGAL) to distinguish pre-renal from established acute kidney injury. Although these results are promising, several caveats need to be considered and applied for future confirmatory studies.
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, San Diego, California 92103, USA. rmehta@ucsd.edu
authors.forename: Ravindra L
authors.initials: RL
authors.lastname: Mehta
mesh_terms: D058186:Acute Kidney Injury / Q000652:urine*; D000209:Acute-Phase Proteins / Q000652:urine*; D005260:Female; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008297:Male; D011518:Proto-Oncogene Proteins / Q000652:urine*
chemical_list: D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins