title: A new monacolin analogue from Xuezhikang capsule.
abstract: Xuezhikang capsule (ethanol extract of red yeast rice) which produced by Beijing WBL Peking University Biotech Co., Ltd., is a traditional Chinese medication with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibiting activity. Clinical trials indicated that Xuezhikang with lipid-lowering action could reduce the risk of cardiac events and total mortality of Chinese coronary heart disease patients. To exactly explain the clinical features of Xuezhikang, we undertook a complete study of the chemical constituents of Xuezhikang. This study resulted in the isolation of a new monacolin analogue, named alpha, beta-dehydromonacolin L (1), along with two known compounds: monacolin L (2) and 3-(2, 6-dimethyl-1, 2, 4a, 5, 6, 7, 8, 8a-octahydronaphthalen-1-yl)propanoic acid (3). The chemical structures were determined by extensive 1D and 2D NMR and MS spectroscopic analysis.
authors.affiliation: College of Chemistry and Molecular Engineering, Peking University, Bei4ing 100871, China.
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Li
authors.forename: Xing-hai
authors.initials: XH
authors.lastname: Shen
authors.forename: Zhen-wen
authors.initials: ZW
authors.lastname: Duan
authors.forename: Shu-ren
authors.initials: SR
authors.lastname: Guo
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification*; D011422:Propionates / Q000737:chemistry / Q000302:isolation & purification
chemical_list: C578904:3-(2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)propanoic acid; D004365:Drugs, Chinese Herbal; D009281:Naphthalenes; D011422:Propionates; C578903:alpha,beta-dehydromonacolin L; C496822:xuezhikang; C045375:monacolin L