title: Neuroendocrine effects of endocrine disruptors in teleost fish.
abstract: Because a large proportion of potential endocrine disruptors (EDC) end up in surface waters, aquatic species are particularly vulnerable to their potential adverse effects. Recent studies identified a number of brain targets for EDC commonly present in environmentally relevant concentrations in surface waters. Among those neuronal systems disrupted by EDC are the gonadotropin-releasing hormone (GnRH) neurons, the dopaminergic and serotoninergic circuits, and more recently the Kiss/GPR54 system, which regulates gonadotropin release. However, one of the most striking effects of EDC, notably estrogen mimics, is their impact on the cyp19a1b gene that encodes the brain aromatase isoform in fish. Moreover, this is the only example in which the molecular basis of endocrine disruption is fully understood. The aims of this review were to (1) synthesize the most recent discoveries concerning the EDC effects upon neuroendocrine systems of fish and (2) provide, when possible, the underlying molecular basis of disruption for each system concerned. The potential adverse effects of EDC on neurogenesis, puberty, and brain sexualization are also described. It is important to point out the future environmental, social, and economical issues arising from endocrine disruption studies in the context of risk assessment.
authors.affiliation: Neurogenesis and Estrogens, UMR CNRS 6026, Rennes, France. ylepage@univ-rennes1.fr
authors.forename: Yann
authors.initials: Y
authors.lastname: Le Page
authors.forename: Mélanie
authors.initials: M
authors.lastname: Vosges
authors.forename: Arianna
authors.initials: A
authors.lastname: Servili
authors.forename: François
authors.initials: F
authors.lastname: Brion
authors.forename: Olivier
authors.initials: O
authors.lastname: Kah
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D052244:Endocrine Disruptors / Q000633:toxicity*; D005399:Fishes; D055495:Neurogenesis / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000378:metabolism; D018570:Risk Assessment; D012741:Sexual Maturation / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D052244:Endocrine Disruptors; D014874:Water Pollutants, Chemical