title: Lung-targeted delivery system of curcumin loaded gelatin microspheres.
abstract: The purpose of the study is to design and evaluate curcumin loaded gelatin microspheres (C-GMS) for effective drug delivery to the lung. C-GMS was prepared by the emulsification-linkage technique and the formulation was optimized by orthogonal design. The mean encapsulation efficiency and drug loading of the optimal C-GMS were 75.5 ± 3.82 % and 6.15 ± 0.44%, respectively. The C-GMS presented a spherical shape and smooth surface with a mean particle diameter of 18.9 μm. The in vitro drug release behavior of C-GMS followed the first-order kinetics. The tissue distribution showed that the drug concentrations at lung tissue for the C-GMS suspension were significantly higher than those for the curcumin solution, and the Ce for lung was 36.19. Histopathological studies proved C-GMS was efficient and safe to be used as a passive targeted drug delivery system to the lung. Hence, C-GMS has a great potential for the targeted delivery of curcumin to the lung.
authors.affiliation: Department of Pharmacy, Shandong University Hospital, Jinan 250012, China.
authors.forename: Fengliang
authors.initials: F
authors.lastname: Cao
authors.forename: Buyun
authors.initials: B
authors.lastname: Ding
authors.forename: Min
authors.initials: M
authors.lastname: Sun
authors.forename: Chenyu
authors.initials: C
authors.lastname: Guo
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Guangxi
authors.initials: G
authors.lastname: Zhai
mesh_terms: D000825:Animal Structures / Q000378:metabolism; D000818:Animals; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D003474:Curcumin / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions; D005557:Formaldehyde / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D005976:Glutaral / Q000737:chemistry; D006601:Hexoses / Q000737:chemistry; D007275:Injections, Intravenous; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000188:drug therapy*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D008899:Mineral Oil / Q000737:chemistry; D010316:Particle Size; D011208:Powders / Q000737:chemistry; D011817:Rabbits; D012212:Rheology; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D014018:Tissue Distribution; D044366:Transition Temperature
chemical_list: D004655:Emulsions; D006601:Hexoses; D011208:Powders; D013501:Surface-Active Agents; C018665:sorbitan monooleate; D005557:Formaldehyde; D008899:Mineral Oil; D005780:Gelatin; D003474:Curcumin; D005976:Glutaral