title: Acute Kidney Injury in ADPKD Patients with Pneumonia.
abstract: Background. In animal models, polycystic kidneys are susceptible to acute kidney injury (AKI). We examined the occurrence of AKI in a cohort of autosomal dominant polycystic kidney disease (ADPKD) and non-ADPKD patients with acute pneumonia. Design. All ADPKD patients admitted to Mayo Clinic Rochester for pneumonia from January 1990 to April 2010 were examined. Sixty-three patients had lobar infiltration and consolidation on chest X-ray. After excluding patients on dialysis, with organ transplantation, and on chronic immunosuppression, 24 remaining ADPKD patients were enrolled. Twenty-three of the 24 were matched with 92 (1 : 4 ratio) non-ADPKD pneumonia patients based on their baseline eGFR. AKI was defined as serum creatinine elevation ≥0.3 mg/dL. Results. Sixteen of the 23 ADPKD patients (69.6%) and 36 of the 92 (39.1%) non-ADPKD patients developed AKI, P = 0.008. In both groups, those who developed AKI had a lower baseline eGFR (41.1 ± 5.00 versus 58.7 ± 11.8 in ADPKD and 40.2 ± 3.65 versus 51.8 ± 2.24 mL/min/1.73 m(2) in the non-ADPKD group), more intensive care unit admissions, and longer hospital stays. AKI was associated with a reduced survival in both groups. Conclusions. Patients with ADPKD admitted for acute pneumonia had more frequent episodes of AKI than non-ADPKD patients with comparable kidney function.
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Mayo Medical School, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Carlos
authors.initials: C
authors.lastname: Franco Palacios
authors.forename: Mira T
authors.initials: MT
authors.lastname: Keddis
authors.forename: Dingxin
authors.initials: D
authors.lastname: Qin
authors.forename: Ladan
authors.initials: L
authors.lastname: Zand
authors.forename: Guangxi
authors.initials: G
authors.lastname: Li
authors.forename: Xiangling
authors.initials: X
authors.lastname: Wang
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cartin-Ceba
authors.forename: Robert P
authors.initials: RP
authors.lastname: Hartman
authors.forename: Qi
authors.initials: Q
authors.lastname: Qian