title: Predictive factors of advanced interventional procedures in a multicentre severe postpartum haemorrhage study.
abstract: OBJECTIVE
  Severe postpartum haemorrhage (SPPH) is the leading cause of peripartum hysterectomy and maternal death. There are no easily measurable parameters that indicate the failure of medical therapy and the need for an advanced interventional procedure (AIP) to stop genital tract bleeding. The aim of the study was to define factors predictive of the need for an AIP in the management of emergent PPH.
  
  
  METHODS
  The study included two phases: (1) an initial retrospective study of 257 consecutive patients with SPPH, allowing the determination of independent predictors of AIP, which were subsequently grouped in a predictive score, followed by (2) a multicentre study of 239 patients admitted during 2007, designed to validate the score. The main outcome measure was the need for an AIP, defined as uterine artery embolization, intraabdominal packing, arterial ligation or hysterectomy.
  
  
  RESULTS
  Abnormalities of placental implantation, prothrombin time <50% (or an International Normalized Ratio >1.64), fibrinogen <2 g/l, troponin detectable, and heart rate >115 bpm were independently predictive of the need for an AIP. The SPPH score included each of the five predictive factors with a value of 0 or 1. The greater the SPPH score, the greater the percentage of patients needing an AIP (11% for SPPH 0, to 75% for SPPH ≥2). The AUC of the ROC curve of the SPPH score was 0.80.
  
  
  CONCLUSIONS
  We identified five independent predictors of the need for an AIP in patients with SPPH and persistent bleeding. Using these predictors in a single score could be a reliable screening tool in patients at risk of persistent genital tract bleeding and needing an AIP.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Mobile Care Unit, Lariboisière University Hospital, AP-HP, EA322, Paris Cedex 10, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Gayat
authors.forename: Matthieu
authors.initials: M
authors.lastname: Resche-Rigon
authors.forename: Olivier
authors.initials: O
authors.lastname: Morel
authors.forename: Matthias
authors.initials: M
authors.lastname: Rossignol
authors.forename: Jean
authors.initials: J
authors.lastname: Mantz
authors.forename: Armelle
authors.initials: A
authors.lastname: Nicolas-Robin
authors.forename: Nathalie
authors.initials: N
authors.lastname: Nathan-Denizot
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Lefrant
authors.forename: Frédéric J
authors.initials: FJ
authors.lastname: Mercier
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Samain
authors.forename: Yann
authors.initials: Y
authors.lastname: Fargeaudou
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Barranger
authors.forename: Marie-Josèphe
authors.initials: MJ
authors.lastname: Laisné
authors.forename: Pierre-Henri
authors.initials: PH
authors.lastname: Bréchat
authors.forename: Dominique
authors.initials: D
authors.lastname: Luton
authors.forename: Ingrid
authors.initials: I
authors.lastname: Ouanounou
authors.forename: Patricia Appa
authors.initials: PA
authors.lastname: Plaza
authors.forename: Claire
authors.initials: C
authors.lastname: Broche
authors.forename: Didier
authors.initials: D
authors.lastname: Payen
authors.forename: Alexandre
authors.initials: A
authors.lastname: Mebazaa
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D015331:Cohort Studies; D005260:Female; D005544:Forecasting; D005602:France; D006801:Humans; D020380:Needs Assessment; D006473:Postpartum Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers