title: Bioactivities of triterpenes and a sterol from Syzygium samarangense.
abstract: Cycloartenyl stearate (1a), lupenyl stearate (1b), sitosteryl stearate (1c), and 24-methylenecycloartanyl stearate (1d) (sample 1) from the air-dried leaves of Syzygium samarangense exhibited potent analgesic and anti-inflammatory activities at effective doses of 6.25 mg/kg body weight and 12.5 mg/kg body weight, respectively. Sample 1 also exhibited negligible toxicity on zebrafish embryonic tissues. There were incidences of mortality upon direct exposure of sample 1 to dechorionated embryos, but higher mortality and aberration were observed during intact chorion treatment.
authors.affiliation: Biology Department and Center for Natural Sciences and Ecological Research, De La Salle University, 2401 Taft Avenue, Manila 1004, Philippines. dennis.raga@dlsu.edu.ph
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Raga
authors.forename: Candice Louise C
authors.initials: CL
authors.lastname: Cheng
authors.forename: Kate Catherine Ilona C
authors.initials: KC
authors.lastname: Lee
authors.forename: Wileen Zoe P
authors.initials: WZ
authors.lastname: Olaziman
authors.forename: Vernon Joseph A
authors.initials: VJ
authors.lastname: De Guzman
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Shen
authors.forename: Francisco C
authors.initials: FC
authors.lastname: Franco
authors.forename: Consolacion Y
authors.initials: CY
authors.lastname: Ragasa
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D013261:Sterols / Q000302:isolation & purification / Q000494:pharmacology*; D027842:Syzygium / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D015027:Zebrafish / Q000196:embryology*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D013261:Sterols; D014315:Triterpenes