title: Pseudomonas aeruginosa tssC1 links type VI secretion and biofilm-specific antibiotic resistance.
abstract: Biofilm-specific antibiotic resistance is influenced by multiple factors. We demonstrated that Pseudomonas aeruginosa tssC1, a gene implicated in type VI secretion (T6S), is important for resistance of biofilms to a subset of antibiotics. We showed that tssC1 expression is induced in biofilms and confirmed that tssC1 is required for T6S.
authors.affiliation: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Room 4125, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Hinz
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Nadeau
authors.forename: Thien-Fah
authors.initials: TF
authors.lastname: Mah
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000187:drug effects*; D004352:Drug Resistance, Microbial / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D008826:Microbial Sensitivity Tests; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins