title: Realization and properties of biochemical-computing biocatalytic XOR gate based on enzyme inhibition by a substrate.
abstract: We consider a realization of the XOR logic gate in a process biocatalyzed by an enzyme which can be inhibited by a substrate when the latter is inputted at large enough concentrations. A model is developed for describing such systems in an approach suitable for evaluation of the analog noise amplification properties of the gate. The obtained data are fitted for gate quality evaluation within the developed model, and we discuss aspects of devising XOR gates for functioning in "biocomputing" systems utilizing biomolecules for information processing.
authors.affiliation: Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, New York 13699, United States.
authors.forename: Jan
authors.initials: J
authors.lastname: Halámek
authors.forename: Vera
authors.initials: V
authors.lastname: Bocharova
authors.forename: Mary A
authors.initials: MA
authors.lastname: Arugula
authors.forename: Guinevere
authors.initials: G
authors.lastname: Strack
authors.forename: Vladimir
authors.initials: V
authors.lastname: Privman
authors.forename: Evgeny
authors.initials: E
authors.lastname: Katz
mesh_terms: D055162:Biocatalysis; D006735:Horseradish Peroxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000494:pharmacology*; D008954:Models, Biological; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013997:Time Factors
chemical_list: D006861:Hydrogen Peroxide; D006735:Horseradish Peroxidase