title: Ultrasound promoted the synthesis of N-propargylic β-enaminones.
abstract: The synthesis of 14 novel N-propargylic β-enaminones from the reaction of β-alkoxy vinyltrihalomethyl[carboxyethyl] ketones [R(3)C(O)CHC(R(1))OMe, where R(3)=CF(3), CCl(3), CO(2)Et and R(1)=Me, Et, Pr, Bu, i-Pent, CH(2)CH(2)CO(2)Me] with propargyl amines [R(2)NHCH(2)CCH, where R(2)=Pr, PhCH(2)] is reported. Yields, solvents and reaction times needed for reaction completion, by microwave irradiation (MW), conventional thermal heating (TH) and under ultrasound irradiation (US) are compared. The best results were obtained under US irradiation in good to excellent yields (70-93%).
authors.affiliation: NUQUIMHE, Departamento de Química, Universidade Federal de Santa Maria, 97105 900 Santa Maria, RS, Brazil. mmartins@base.ufsm.br
authors.forename: Marcos A P
authors.initials: MA
authors.lastname: Martins
authors.forename: Marcelo
authors.initials: M
authors.lastname: Rossatto
authors.forename: Liziê D T
authors.initials: LD
authors.lastname: Prola
authors.forename: Lucas
authors.initials: L
authors.lastname: Pizzuti
authors.forename: Dayse N
authors.initials: DN
authors.lastname: Moreira
authors.forename: Patrick T
authors.initials: PT
authors.lastname: Campos
authors.forename: Clarissa P
authors.initials: CP
authors.lastname: Frizzo
authors.forename: Nilo
authors.initials: N
authors.lastname: Zanatta
authors.forename: Helio G
authors.initials: HG
authors.lastname: Bonacorso