title: [Adipocytokines: emerging mediators of the immune response and inflammation].
abstract: Scientific interest in the biology of white adipose tissue (WAT) has increased since the discovery of leptin in 1994. The description of the effects of leptin, the product of the ob gene, has started to clarify the role of adipose tissue in the physiopathology of obesity related diseases and has helped in the identification of a great number of other molecules (named adipocytokines), some of them with a proinflammatory nature. In rheumatic diseases, adipocytokines derived from the WAT are among the most important factors related to obesity and promote inflammatory and/or autoimmune conditions. In this review we will present the most recent advances in adipocytokine research, with special attention to the role of leptin, adiponectin, resistin and visfatin and inflammatory, autoimmune and rheumatic diseases.
authors.affiliation: Área de Investigación, Laboratorio 9 Instituto de Investigación Sanitaria de Santiago NEIRID (Interacciones Neuroendocrinas en Enfermedades Reumáticas e Inflamatorias), Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, España.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Gómez
authors.forename: Javier
authors.initials: J
authors.lastname: Conde
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Gómez Reino
authors.forename: Francisca
authors.initials: F
authors.lastname: Lago
authors.forename: Oreste
authors.initials: O
authors.lastname: Gualillo