title: Association of adipose tissue blood flow with fat depot sizes and adipokines in women.
abstract: OBJECTIVE
  To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocyte-derived hormones (adipokines) in women.
  
  
  METHODS
  In all, 43 healthy women were divided into four groups: normal-weight (n=11) and obese (n=11) pre-menopausal women and normal-weight (n=10) and obese (n=11) post-menopausal women.
  
  
  METHODS
  Fasting levels of adipokines were obtained, and a single-slice computed tomography scan at the level of L4-L5 was used to estimate fat depot sizes. ATBF was assessed by xenon washout while in a fasting state and after oral glucose load. We also measured glucose, insulin and non-esterified fatty acids.
  
  
  RESULTS
  Total, subcutaneous and visceral AT areas strongly correlated with ATBF (all P<0.001). Circulating leptin levels strongly and inversely correlated with ATBF (P=0.001), but this association did not remain after adjustment for body mass index. Adiponectin was not associated with blood flow.
  
  
  CONCLUSIONS
  ATBF is closely linked to subcutaneous and visceral AT size. Further analyses are needed to determine possible mediators of this association, including mechanistic studies to assess a putative role for leptin as a significant modulator of blood flow.
authors.affiliation: Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden. jonas.andersson@medicin.umu.se
authors.forename: J
authors.initials: J
authors.lastname: Andersson
authors.forename: F
authors.initials: F
authors.lastname: Karpe
authors.forename: L-G
authors.initials: LG
authors.lastname: Sjöström
authors.forename: K
authors.initials: K
authors.lastname: Riklund
authors.forename: S
authors.initials: S
authors.lastname: Söderberg
authors.forename: T
authors.initials: T
authors.lastname: Olsson
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000098:blood supply*; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D009765:Obesity / Q000097:blood*; D017698:Postmenopause / Q000097:blood; D017697:Premenopause / Q000097:blood; D050151:Subcutaneous Fat / Q000098:blood supply; D055815:Young Adult
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D020738:Leptin; D009569:Nitric Oxide