title: [Pharmacokinetics of Guizhi Fuling capsule in Beagle dogs].
abstract: OBJECTIVE
  To investigate pharmacokinetic parameters of peoniflorin, albiflorin and amygdaloside after administration of Guizhi Fuling capsule in beagle dogs.
  
  
  METHODS
  Plasma was collected from forelimb vein of Beagle dogs after oral administration of Guizhi Fuling capsule. HPLC-MS/MS method was used to determine the concentrations of constituents in plasma. The pharmacokinetic parameters were analyzed by program DAS 2.0.
  
  
  RESULTS
  The limit of quantitation of peoniflorin, albiflorin and amygdaloside were 0.25, 2.64, 0.04 microg x L(-1), respectively. After administrated with different doses, half-life of peoniflorin in dogs were 4.33, 3.62 h, albiflorin were 6.16, 5.91 h, amygdaloside were 2.43, 1.32 h. The AUC(0-t) of all components were related to dose.
  
  
  CONCLUSIONS
  The pharmacokinetic course of peoniflorin, albiflorin and amygdaloside can be described by two-compartment model, and these components have high expose.
authors.affiliation: Jangsu Kanion Pharmaceutical Co., Ltd. , Lianyungang 222001, China. kanion-xw2010@126.com
authors.forename: Kejin
authors.initials: K
authors.lastname: Zhu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Sun
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Chang
authors.forename: Jianping
authors.initials: J
authors.lastname: Qin
authors.forename: Xinyong
authors.initials: X
authors.lastname: Lv
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D000284:Administration, Oral; D000678:Amygdalin / Q000097:blood*; D000818:Animals; D019540:Area Under Curve; D001565:Benzoates / Q000097:blood*; D001952:Bridged-Ring Compounds / Q000097:blood*; D002214:Capsules / Q000008:administration & dosage / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005960:Glucosides / Q000097:blood*; D006207:Half-Life; D008297:Male; D039821:Monoterpenes; D053719:Tandem Mass Spectrometry / Q000379:methods; D006027:Glycosides
chemical_list: D000678:Amygdalin; D001565:Benzoates; D001952:Bridged-Ring Compounds; D002214:Capsules; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D039821:Monoterpenes; C525079:guizhi-fuling; C015423:peoniflorin; D006027:Glycosides; C014959:albiflorin