title: Colonic expression of Runx3 protein and TGF-β(1) and their correlation in patients with irritable bowel syndrome.
abstract: OBJECTIVE
  To investigate the role of Runx3 protein and TGF-β(1) in the pathogenesis of irritable bowel syndrome (IBS), as well as the correlation of these two proteins.
  
  
  METHODS
  Colonic tissue was collected from patients with IBS and normal persons. The colonic expression of Runx3 protein and TGF-β(1) was detected with immunohistochemistry method. Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.
  
  
  RESULTS
  Compared with their counterparts, patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β(1) (P>0.05). Interestingly, there was a significant correlation between Runx3 protein and TGF-β(1) in patients with IBS(P<0.05).
  
  
  CONCLUSIONS
  The role of Runx3 protein and TGF-β(1) in the pathogenesis of IBS remains to be further studied.
authors.affiliation: Department of Gastroenterology, Hainan Provincial People's Hospital, Haikou 570311, China. xnsun_0108@163.com
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Sun
authors.forename: Cheng
authors.initials: C
authors.lastname: Lan
authors.forename: Yu
authors.initials: Y
authors.lastname: An
authors.forename: Ye
authors.initials: Y
authors.lastname: Sun
mesh_terms: D003106:Colon / Q000378:metabolism* / Q000473:pathology; D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D043183:Irritable Bowel Syndrome / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D050677:Core Binding Factor Alpha 3 Subunit; D053773:Transforming Growth Factor beta1