title: Neuronal integration and the depolarizing effects of axonal GABA(A) receptors.
abstract: Despite their presence throughout the central nervous system, the impact of axonally expressed gamma-amino-butyric acid type-A receptors (GABA(A)Rs) on neuronal signaling is just beginning to be understood. A recently published article (Pugh JR and Jahr CE, J Neurosci 31: 565-574, 2011) tackled this important issue by investigating GABA(A)R-mediated function in axons of cerebellar granule cells. The results of Pugh and Jahr indicate parallel fiber GABA(A)Rs enhance neurotransmitter release probability and boost axonal and somatic excitability.
authors.affiliation: Dominick P. Purpura Dept. of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Rose F. Kennedy Bldg., Rm. 703, Bronx, NY 10461, USA. thomas.younts@phd.einstein.yu.edu
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Younts
authors.forename: Sachin
authors.initials: S
authors.lastname: Makani