title: Total parenteral nutrition and cancer: from the beginning.
abstract: The early development of total parenteral nutrition and its evolution as an adjunct to the nutritional, metabolic, and antineoplastic therapy of cancer patients is described. Examples related to the sine wave of responses to new data and discovery are placed in context to understand better past, present, and how and where to proceed in the future to achieve optimal results from multimodal comprehensive management of patients with malignancies. Practical and philosophic thoughts are proffered to justify continued, intensified, logical, controlled clinical studies directed toward establishing the most rational, safe, and effective use of total parenteral nutrition in treating patients with cancer.
authors.affiliation: Department of Surgery, University of Florida College of Medicine, 1600 Southwest Archer Road, Gainesville, FL 32607, USA. copelem@surgery.ufl.edu
authors.forename: Edward M
authors.initials: EM
authors.lastname: Copeland
authors.forename: Jose Mario
authors.initials: JM
authors.lastname: Pimiento
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Dudrick
mesh_terms: D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D044342:Malnutrition / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D009369:Neoplasms / Q000150:complications / Q000266:history*; D010289:Parenteral Nutrition, Total / Q000266:history*