title: Antimycobacterial activity of fusaric acid from a mangrove endophyte and its metal complexes.
abstract: Due to the increasing prevalence of multidrug-resistant Mycobacterium tuberculosis, there is an urgent need for new antituberculosis drugs that have novel mechanisms of action. As part of our ongoing search for antimycobacterial metabolites from mangrove endophytes, chemical analysis of the active extract of a strain of Fusarium sp. was performed, which led to the isolation of fusaric acid as the predominant constituent. A variety of metal complexes of fusaric acid were prepared. Antimycobacterial assays showed that Cadmium (II) and Copper (II) complexes exhibited potent inhibitory activity against the M. bovis BCG strain [minimum inhibitory concentration (MIC) = 4 μg/mL] and the M. tuberculosis H37Rv strain (MIC = 10 μg/mL), respectively. This is the first report of the antimycobacterial activity of the mangrove Fusarium metabolite and its coordinating metal complexes.
authors.affiliation: Ministry of Education Key Laboratory of Tropical Diseases Control, Guangdong Provincial, Department of Education Key Laboratory of Functional Molecules from Marine Microorganisms, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Pan
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Huang
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Tao
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Peng
authors.forename: Tao
authors.initials: T
authors.lastname: Dong
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Lai
authors.forename: Yong-Cheng
authors.initials: YC
authors.lastname: Lin
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D060026:Endophytes / Q000737:chemistry*; D005669:Fusaric Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005670:Fusarium / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D008517:Phytotherapy; D024301:Plant Bark; D043982:Rhizophoraceae
chemical_list: D000995:Antitubercular Agents; D001688:Biological Products; D056831:Coordination Complexes; D005669:Fusaric Acid