title: Decreased serum brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia.
abstract: The pathogenesis of tardive dyskinesia (TD) may involve neurodegeneration and associated dysfunction of brain-derived neurotrophic factor (BDNF) for the survival and maintenance of function in neurons. We therefore compared serum BDNF levels in schizophrenic patients with (n=129) and without TD (n=235), and normal controls (n=323). Assessments included the abnormal involuntary movement scale (AIMS) and the positive and negative syndrome scale (PANSS). Our results were that patients with TD had lower serum BDNF levels than those without TD and normals. Lower serum BDNF levels were correlated with greater PANSS negative subscores, but not correlated with the AIMS scores. Serum BDNF levels did not differ between patients on typical and atypical antipsychotics and were not correlated with antipsychotic doses or years of exposure. We concluded that decreased BDNF levels might be associated with TD pathophysiology and more negative symptoms of schizophrenia.
authors.affiliation: The First Hospital of Jilin University, Changchun, China.
authors.forename: Yan Qiu
authors.initials: YQ
authors.lastname: Yang
authors.forename: Shilong
authors.initials: S
authors.lastname: Sun
authors.forename: Ya Qin
authors.initials: YQ
authors.lastname: Yu
authors.forename: Wen Jun
authors.initials: WJ
authors.lastname: Li
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Mei Hong
authors.initials: MH
authors.lastname: Xiu
authors.forename: Da Chun
authors.initials: DC
authors.lastname: Chen
authors.forename: Fu
authors.initials: F
authors.lastname: De Yang
authors.forename: Haibo
authors.initials: H
authors.lastname: Liu
authors.forename: Cunbo
authors.initials: C
authors.lastname: Li
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Kosten
authors.forename: Xiang Yang
authors.initials: XY
authors.lastname: Zhang
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D016022:Case-Control Studies; D004409:Dyskinesia, Drug-Induced / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000097:blood* / Q000150:complications; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000097:blood* / Q000150:complications; D012720:Severity of Illness Index
chemical_list: D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor