title: Association study between sick building syndrome and polymorphisms of seven human detoxification genes in the Japanese.
abstract: Sick building syndrome (SBS) is a chronic disorder caused by exposure to diverse indoor environmental or chemical pollutants. This study examined the association between seven detoxification genes (CYP1A1, CYP2E1, EPHX1, GSTM1, GSTT1, GSTP1, and NAT2) and SBS in the Japanese population. One hundred eighty patients with SBS and 401 healthy controls were enrolled in this study. We examined the prevalence for total of eleven genetic polymorphisms of detoxification genes. However, no statistically significant differences in allele and genotype frequency distributions of eleven genetic polymorphisms of these detoxification genes were found between patients and controls. On this basis, we conclude that the polymorphisms that we assessed for the detoxification genes do not contribute to the etiology of SBS.
authors.affiliation: Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Matsuzaka
authors.forename: Yukie Y
authors.initials: YY
authors.lastname: Kikuti
authors.forename: Akiko
authors.initials: A
authors.lastname: Mizutani
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Aoyama
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kakuta
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Kou
authors.initials: K
authors.lastname: Sakabe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Jerzy K
authors.initials: JK
authors.lastname: Kulski
authors.forename: Minoru
authors.initials: M
authors.lastname: Kimura