title: Efficacy of indacaterol in the treatment of patients with COPD.
abstract: Effective bronchodilation is an important part of the management of patients with chronic obstructive pulmonary disease (COPD) and  can improve breathlessness and ability to undertake physical activities. Indacaterol is a new once-daily, long-acting inhaled bronchodilator  for COPD. We review here the efficacy of indacaterol as a bronchodilator, including its impact upon symptoms and health status. The  evidence reviewed comprises four placebo-controlled clinical studies of indacaterol treatment, three of which included treatment arms  with one of the other long-acting inhaled bronchodilators (once-daily tiotropium or twice-daily salmeterol or formoterol), in 4,833  patients with moderate-to-severe COPD. Indacaterol had a bronchodilator effect significantly greater than formoterol and salmeterol, and  similar to tiotropium. Its effect on symptoms and health status was similar or significantly greater than the other bronchodilators. The  safety profile was similar to placebo. Once-daily indacaterol is an effective and beneficial maintenance bronchodilator treatment for  patients with moderate-to-severe COPD.
authors.affiliation: Division of Clinical Sciences, St. George's University of London, London, UK. pjones@sgul.ac.uk
authors.forename: Paul W
authors.initials: PW
authors.lastname: Jones
authors.forename: Neil
authors.initials: N
authors.lastname: Barnes
authors.forename: Claus
authors.initials: C
authors.lastname: Vogelmeier
authors.forename: David
authors.initials: D
authors.lastname: Lawrence
authors.forename: Benjamin
authors.initials: B
authors.lastname: Kramer
mesh_terms: D000368:Aged; D000420:Albuterol / Q000627:therapeutic use; D001993:Bronchodilator Agents / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007189:Indans / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D015363:Quinolones / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index
chemical_list: D001993:Bronchodilator Agents; D007189:Indans; D015363:Quinolones; C510790:indacaterol; D000420:Albuterol