title: A fast degrading odd-odd aliphatic polyester-5,7 made by condensation polymerization for biomedical applications.
abstract: A fast enzymatic degradable aliphatic all-odd-polyester-5,7, based on 1,7-heptanedioic acid (pimelic acid) and 1,5-pentanediol, was synthesized by polycondensation. The structural characterization of the polyester was done using 1D- and 2D-NMR spectroscopic techniques. The properties of the resulting polyester-like crystallization behavior, enzymatic degradation, thermal stability, etc., were investigated using differential scanning calorimetry, wide-angle X-ray diffraction, scanning electron microscopy and gel-permeation chromatography. Terahertz time-domain spectroscopy was employed to determine the glass transition temperature, which could not be revealed reliably by conventional thermal analysis. The properties of all-odd-polyester-5,7 were compared with a well-known enzymatic degradable polyester (polycaprolactone). The results indicated that polyester-5,7 has a crystal structure similar to PCL, but a much faster degradation rate. The morphology of polyester-5,7 film during enzymatic degradation showed a fibrillar structure and degradation began by surface erosion.
authors.affiliation: a Philipps-Universität Marburg, Fachbereich Chemie , Hans-Meerwein Strasse , D-35032 , Marburg , Germany.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Jan Martin
authors.initials: JM
authors.lastname: Nölle
authors.forename: Steffen
authors.initials: S
authors.lastname: Wietzke
authors.forename: Marco
authors.initials: M
authors.lastname: Reuter
authors.forename: Sangam
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Martin
authors.initials: M
authors.lastname: Koch
authors.forename: Seema
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D016956:Burkholderia cepacia; D002152:Calorimetry, Differential Scanning; D002850:Chromatography, Gel; D007700:Kinetics; D008049:Lipase / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D058105:Polymerization; D055068:Terahertz Spectroscopy; D044366:Transition Temperature; D014961:X-Ray Diffraction
chemical_list: D011091:Polyesters; C016240:polycaprolactone; D008049:Lipase