title: Development of evidence-based exercise recommendations for older HIV-infected patients.
abstract: Advances in antiretroviral therapy (ART) have decreased HIV-related morbidity and mortality and contributed to rapidly increasing numbers of older people living with HIV. Successful management of ART-related side effects (metabolic syndrome) and age-related comorbidities (frailty) are major challenges for patients and providers. Exercise has proven beneficial for younger HIV-infected patients, but we know little about which exercise regimens to recommend to the elderly. Our goal was to develop age-appropriate, evidence-based exercise recommendations for older HIV-infected adults (age > 50). We reviewed randomized controlled trials on the effects of physical exercise for: (a) HIV-infected young adults, (b) frail older adults, and (c) elderly individuals with metabolic syndrome. We recommend a combination of endurance and resistance exercises 3 times per week for at least 6 weeks to improve cardiovascular, metabolic, and muscle function. Further research is warranted to study the benefits and risks of physical exercise in older HIV-infected patients.
authors.affiliation: University of Washington, Seattle, WA, USA.
authors.forename: Anella
authors.initials: A
authors.lastname: Yahiaoui
authors.forename: Ellen L
authors.initials: EL
authors.lastname: McGough
authors.forename: Joachim G
authors.initials: JG
authors.lastname: Voss
mesh_terms: D000328:Adult; D019317:Evidence-Based Medicine; D015444:Exercise; D017408:Guidelines as Topic; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications / Q000503:physiopathology; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic