title: Bilateral acute retinal necrosis associated with neuroinfection in patient after renal transplantation.
abstract: BACKGROUND
  Acute retinal necrosis (ARN) is characterized by the triad of acute vitritis, peripheral necrotizing retinitis and vasculitis.
  
  
  METHODS
  We report a case of 54-year-old woman with bilateral acute retinal necrosis associated with neuroinfection. Her past medical history included renal transplantation, hypertension and aortic stenosis. Observational case report: Diagnostic investigations included biochemical tests, lumbar puncture, eye ultrasonography and MRI of the brain. Anti-HSV IgG antibody titers were elevated in the blood and cerebrospinal fluid. In MRI T2-mode, inflammatory changes were found in the white matter of the right hemisphere. The patient was treated with systemic acyclovir, itraconazole, metronidazole and ciprofloxacin for 3 weeks. Retinal detachment was observed in both eyes.
  
  
  CONCLUSIONS
  Acute retinal necrosis can be the single manifestation of herpes virus reactivation in patients after organ transplantation.
authors.affiliation: Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland. joannabg@tlen.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Brydak-Godowska
authors.forename: Szymon
authors.initials: S
authors.lastname: Szczepanik
authors.forename: Michal
authors.initials: M
authors.lastname: Ciszek
authors.forename: Dominika
authors.initials: D
authors.lastname: Bialas
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Grzeszczyk
authors.forename: Dariusz
authors.initials: D
authors.lastname: Strzeleck
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kecik
mesh_terms: D000998:Antiviral Agents; D002494:Central Nervous System Infections / Q000150:complications* / Q000209:etiology* / Q000473:pathology; D015828:Eye Infections, Viral / Q000150:complications* / Q000473:pathology / Q000821:virology; D005260:Female; D006561:Herpes Simplex / Q000150:complications / Q000209:etiology / Q000473:pathology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology; D015882:Retinal Necrosis Syndrome, Acute / Q000209:etiology* / Q000473:pathology*; D014775:Virus Activation
chemical_list: D000998:Antiviral Agents