title: Nerve agent intoxication: recent neuropathophysiological findings and subsequent impact on medical management prospects.
abstract: This manuscript provides a survey of research findings catered to the development of effective countermeasures against nerve agent poisoning over the past decade. New neuropathophysiological distinctive features as regards organophosphate (OP) intoxication are presented. Such leading neuropathophysiological features include recent data on nerve agent-induced neuropathology, related peripheral or central nervous system inflammation and subsequent angiogenesis process. Hence, leading countermeasures against OP exposure are down-listed in terms of pre-treatment, protection or decontamination and emergency treatments. The final chapter focuses on the description of the self-repair attempt encountered in lesioned rodent brains, up to 3months after soman poisoning. Indeed, an increased proliferation of neuronal progenitors was recently observed in injured brains of mice subjected to soman exposure. Subsequently, the latter experienced a neuronal regeneration in damaged brain regions such as the hippocampus and amygdala. The positive effect of a cytokine treatment on the neuronal regeneration and subsequent cognitive behavioral recovery are also discussed in this review. For the first time, brain cell therapy and neuronal regeneration are considered as a valuable contribution towards delayed treatment against OP intoxication. To date, efficient delayed treatment was lacking in the therapeutic resources administered to patients contaminated by nerve agents.
authors.affiliation: Département de Toxicologie, IRBA/CRSSA, 24 avenue des Maquis du Grésivaudan, B.P. 87, 38702 LA TRONCHE cedex, France. jmcollombet@imassa.fr
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Collombet
mesh_terms: D000818:Animals; D002619:Chemical Warfare Agents / Q000009:adverse effects / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects / Q000633:toxicity; D019468:Disease Management; D006801:Humans; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy*; D012999:Soman / Q000009:adverse effects / Q000633:toxicity*
chemical_list: D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D012999:Soman