title: Effects of maternal cadmium administration on development of monoaminergic, GABAergic and glutamatergic systems.
abstract: The effects of maternal exposure to 10mgCd/l (as cadmium acetate) in drinking water during gestation and lactation on the development of monoaminergic and aminoacidergic systems were studied in discrete brain areas of the pups: striatum, cerebral cortex, dorsal hippocampus and basal-medial hypothalamus. Hippocampal levels of serotonin and 5-hydroxyindolacetic acid were significantly reduced in rats exposed to Cd whereas the dopamine content was not significantly affected by Cd. Glutamate concentration decreased in hypothalamus and increased in hippocampus, while gamma-aminobutiric acid content decreased only in cerebral cortex. The present results demonstrate that maternal exposure to 10mg/l of Cd leads to neurochemical disturbances on serotoninergic and aminoacidergic systems during development.
authors.affiliation: Dpt of Animal Physiology, Faculty of Biological Sciences, Complutense University, C/José Antonio Novais, 2, 28040 Madrid, Spain.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Antonio
authors.forename: Victoria
authors.initials: V
authors.lastname: Peinado
authors.forename: José Carlos
authors.initials: JC
authors.lastname: González
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Leret