title: NeurimmiRs: microRNAs in the neuroimmune interface.
abstract: Recent reports of microRNA (miR) modulators of both neuronal and immune processes (here termed NeurimmiRs) predict therapeutic potential for manipulating NeurimmiR levels in diseases affecting both the immune system and higher brain functions, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS) and anxiety-related disorders. In our opinion, NeurimmiRs that function within both the nervous and the immune systems, such as miR-132 and miR-124, may act as 'negotiators' between these two interacting compartments. We suggest that NeurimmiRs primarily target transcriptional or other regulatory genes, which enables modulation of both immune and cognitive processes through direct or indirect alterations of neuron-glia and/or brain-to-body signaling. Thus, manipulating NeurimmiR control over the immune contributions to cognitive pathways may offer new therapeutic targets.
authors.affiliation: Institute of Life Sciences and Edmond and Lily Safra Center of Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 91904, Israel. soreq@cc.huji.ac.il
authors.forename: Hermona
authors.initials: H
authors.lastname: Soreq
authors.forename: Yochai
authors.initials: Y
authors.lastname: Wolf
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000276:immunology; D000818:Animals; D001921:Brain / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology*; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology; D009474:Neurons / Q000276:immunology* / Q000378:metabolism; D010300:Parkinson Disease / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs