title: Clostridium perfringens tpeL is expressed during sporulation.
abstract: Clostridium perfringens TpeL belongs to the family of large clostridial toxins. Although recent studies demonstrated the expression of tpeL during vegetative growth nothing is known about tpeL expression during sporulation. Our current study demonstrated that tpeL: (i) is also expressed during sporulation; (ii) expression is dependent on the master regulator of sporulation, Spo0A, and the sporulation-specific sigma factor, SigE; and (iii) is localized to the mother cell compartment of the sporulating cell. In summary, these results indicate that TpeL is a sporulation-regulated C. perfringens toxin.
authors.affiliation: Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Paredes-Sabja
authors.forename: Nahid
authors.initials: N
authors.lastname: Sarker
authors.forename: Mahfuzur R
authors.initials: MR
authors.lastname: Sarker
mesh_terms: D001427:Bacterial Toxins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D003016:Clostridium perfringens / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D004768:Enterotoxins / Q000235:genetics* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D018507:Gene Expression Regulation, Developmental; D008969:Molecular Sequence Data; D012808:Sigma Factor / Q000235:genetics / Q000378:metabolism; D013171:Spores, Bacterial / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins; D012808:Sigma Factor