title: Multidrug-resistant pandemic (H1N1) 2009 infection in immunocompetent child.
abstract: Recent case reports describe multidrug-resistant influenza A pandemic (H1N1) 2009 virus infection in immunocompromised patients exposed to neuraminidase inhibitors because of an I223R neuraminidase mutation. We report a case of multidrug-resistant pandemic (H1N1) 2009 bearing the I223R mutation in an ambulatory child with no previous exposure to neuraminidase inhibitors.
authors.affiliation: Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada.
authors.forename: AliReza
authors.initials: A
authors.lastname: Eshaghi
authors.forename: Samir N
authors.initials: SN
authors.lastname: Patel
authors.forename: Alicia
authors.initials: A
authors.lastname: Sarabia
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Higgins
authors.forename: Alexei
authors.initials: A
authors.lastname: Savchenko
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Stojios
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bastien
authors.forename: David C
authors.initials: DC
authors.lastname: Alexander
authors.forename: Donald E
authors.initials: DE
authors.lastname: Low
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Gubbay
mesh_terms: D000293:Adolescent; D000998:Antiviral Agents / Q000494:pharmacology*; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D007121:Immunocompetence; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D009154:Mutation; D009439:Neuraminidase / Q000235:genetics; D053139:Oseltamivir / Q000494:pharmacology*; D058873:Pandemics; D053243:Zanamivir / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D053139:Oseltamivir; D009439:Neuraminidase; D053243:Zanamivir