title: Intrahepatic biliary cystadenoma: Is there really an almost exclusively female predominance?
abstract: Biliary cystic tumors, such as cystadenomas and cystadenocarcinomas, are rare cystic tumors of the liver, accounting for less than 5% of all intrahepatic cysts of biliary origin. Biliary cystadenomas have been known to occur predominantly in women (> 85%), and 38%-44% of biliary cystadenocarcinomas have occurred in males. We wrote this letter to comment on a brief article (World J Gasteroenterol 2011 January 21; 17(3): 361-365) regarding a case of intrahepatic biliary cystic neoplasm treated with surgery. The adenoma-carcinoma sequence is the possible mechanism of carcinogenesis. If the carcinogenesis of biliary cystadenocarcinoma occurs in the adenoma-carcinoma sequence, we believe that the male-to-female ratio of cystadenoma should be higher than the incidence rate that has been reported to date.
authors.forename: Ho Hyun
authors.initials: HH
authors.lastname: Kim
authors.forename: Young Hoe
authors.initials: YH
authors.lastname: Hur
authors.forename: Yang Seok
authors.initials: YS
authors.lastname: Koh
authors.forename: Chol Kyoon
authors.initials: CK
authors.lastname: Cho
authors.forename: Jin Woong
authors.initials: JW
authors.lastname: Kim
mesh_terms: D001650:Bile Duct Neoplasms / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D001661:Biliary Tract Neoplasms / Q000601:surgery*; D003560:Cysts / Q000601:surgery*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*