title: [Mechanisms and new innovations in hyposensitization].
abstract: According to established view, the underlying factor in allergic immune response is imbalance between the number and function of allergen-specific CD4+ lymphocytes. In atopic allergy, type 2 helper T lymphocytes (Th2 cells) are elevated in relation to regulatory T lymphocytes (Treg cells). In healthy subjects the ratio is vice versa. It seems that tolerance generated through allergen-specific Treg cells is the immunologic reaction mode towards allergens in healthy non-atopic subjects. It has been found that hyposensitization will correct the imbalance of Th2 and Treg cells and restore the normal immune response to allergens.
authors.affiliation: Turun yliopisto, kliininen laitos ja TYKS:n allergiayksikkö, PL 52, 20521 Turku.
authors.forename: Johannes
authors.initials: J
authors.lastname: Savolainen
authors.forename: Harri
authors.initials: H
authors.lastname: Alenius
authors.forename: Risto
authors.initials: R
authors.lastname: Renkonen
mesh_terms: D000485:Allergens / Q000276:immunology; D003888:Desensitization, Immunologic; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D000485:Allergens