title: Fragrance material review on 3-methylcyclopentadecenone (mixed isomers).
abstract: A toxicologic and dermatologic review of 3-methylcyclopentadecenone when used as a fragrance ingredient is presented. 3-Methylcyclopentadecenone is a member of the fragrance structural group macrocyclic ketones and derivatives. The fragrance ingredient described herein is one of 11 structurally diverse C15, C16 and C17 compounds that include three saturated and eight unsaturated ketones. For the latter, the double bond is not adjacent (in conjugation with) to the ketone group. This review contains a detailed summary of all available toxicology and dermatology papers that are related to 3-methylcyclopentadecenone and is not intended as a stand-alone document. Available data were evaluated, then summarized, and includes: physical properties; acute toxicity; skin irritation; mucous membrane (eye) irritation; skin sensitization; reproductive toxicity; and genotoxicity data. A safety assessment of the entire macrocyclic ketones and derivatives will be published simultaneously with this document. Please refer to Belsito et al., 2011 for an overall assessment of the safe use of this material and all macrocyclic ketones and derivatives in fragrances. Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Hanifin, J.H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2011. A toxicologic and dermatologic assessment of macrocylic ketones and derivatives when used as fragrance ingredients.
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. dmcginty@RIFM.org
authors.forename: D
authors.initials: D
authors.lastname: McGinty
authors.forename: C S
authors.initials: CS
authors.lastname: Letizia
authors.forename: A M
authors.initials: AM
authors.lastname: Api
mesh_terms: D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000473:pathology; D005131:Eye Injuries / Q000139:chemically induced / Q000473:pathology; D017408:Guidelines as Topic; D006801:Humans; D007659:Ketones / Q000737:chemistry* / Q000633:toxicity*; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000633:toxicity*; D009092:Mucous Membrane / Q000187:drug effects; D009812:Odorants; D010476:Perfume / Q000737:chemistry* / Q000633:toxicity*; D012867:Skin / Q000187:drug effects; D018675:Toxicity Tests
chemical_list: C571558:3-methylcyclopentadecenone; D007659:Ketones; D047028:Macrocyclic Compounds; D010476:Perfume