title: Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus.
abstract: OBJECTIVE
  To evaluate and compare circulating concentrations of islet amyloid polypeptide (IAPP), insulin, and glucose in nondiabetic cats classified by body condition score (BCS) and in cats with naturally occurring diabetes mellitus.
  
  
  METHODS
  109 (82 nondiabetic, 21 nonketoacidotic diabetic, and 6 ketoacidotic diabetic) cats.
  
  
  METHODS
  Cats were examined and BCSs were assessed on a scale of 1 to 9. After food was withheld for 12 hours, blood was collected and plasma concentrations of IAPP and serum concentrations of insulin and glucose were measured. Differences in these values were evaluated among nondiabetic cats grouped according to BCS and in diabetic cats grouped as ketoacidotic or nonketoacidotic on the basis of clinicopathologic findings. Correlations were determined among variables.
  
  
  RESULTS
  In nondiabetic cats, BCS was significantly and positively correlated with circulating IAPP and insulin concentrations. Mean plasma IAPP concentrations were significantly different between cats with BCSs of 5 and 7, and mean serum insulin concentrations were significantly different between cats with BCSs of 5 and 8. Serum glucose concentrations were not significantly different among nondiabetic cats. Mean IAPP concentrations were similar between nonketoacidotic diabetic cats and nondiabetic cats with BCSs of 8 or 9. Mean IAPP concentrations were significantly reduced in ketoacidotic diabetic cats, compared with those of nondiabetic cats with BCSs of 6 through 8 and of nonketoacidotic diabetic cats.
  
  
  CONCLUSIONS
  Results indicated that increased BCS (a measure of obesity) is associated with increased circulating concentrations of IAPP and insulin in nondiabetic cats.
authors.affiliation: Departments of Veterinary Clinical Sciences, College of Veterinary Medicine, Saint Paul, MN 55108, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Henson
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Hegstad-Davies
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Robert M
authors.initials: RM
authors.lastname: Hardy
authors.forename: P Jane
authors.initials: PJ
authors.lastname: Armstrong
authors.forename: Kathryn
authors.initials: K
authors.lastname: Jordan
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Johnson
authors.forename: Timothy D
authors.initials: TD
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002371:Cat Diseases / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D002415:Cats; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary; D005260:Female; D007328:Insulin / Q000097:blood / Q000378:metabolism; D058228:Islet Amyloid Polypeptide / Q000096:biosynthesis / Q000097:blood; D016014:Linear Models; D008297:Male; D018709:Statistics, Nonparametric
chemical_list: D001786:Blood Glucose; D007328:Insulin; D058228:Islet Amyloid Polypeptide