title: Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics.
abstract: Among 384 patients with confirmed meningococcal disease, the likelihood of detecting Neisseria meningitidis DNA in cerebrospinal fluid (CSF) increased with age, serogroup B infection, and prehospitalization antibiotic treatment. Plasma and CSF genomic bacterial loads of non-B N. meningitidis serogroups correlated significantly. Serogroup B-infected patients with genotype TNF2 (-308A) had significantly higher CSF bacterial loads.
authors.affiliation: Department of Infection and Immunity, University of Sheffield, Sheffield, UK.
authors.forename: Tom C
authors.initials: TC
authors.lastname: Darton
authors.forename: Malcolm
authors.initials: M
authors.lastname: Guiver
authors.forename: Simone
authors.initials: S
authors.lastname: Naylor
authors.forename: Edward B
authors.initials: EB
authors.lastname: Kaczmarski
authors.forename: Raymond
authors.initials: R
authors.lastname: Borrow
authors.forename: Robert C
authors.initials: RC
authors.lastname: Read
mesh_terms: D000293:Adolescent; D000328:Adult; D058491:Bacterial Load; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000134:cerebrospinal fluid* / Q000302:isolation & purification; D016680:Genome, Bacterial; D005838:Genotype; D006801:Humans; D007223:Infant; D008585:Meningitis, Meningococcal / Q000134:cerebrospinal fluid* / Q000235:genetics / Q000382:microbiology; D009345:Neisseria meningitidis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D004269:DNA, Bacterial