title: Constituents of the root of Anemone tomentosa.
abstract: A new diterpene glycoside, tomentoside I (1), along with eleven known compounds, including the four coumarins, 4,5-dimethoxyl-7-methylcoumarin (2), 4,7-dimethoxyl-5-methylcoumarin (3), isofraxidin (4) and fraxidin (5) as well as the seven triterpenoids, oleanolic acid (6), oleanolic acid 3-O-α-L-arabinopyranoside (7), oleanolic acid 3-O-β-D-galactopyranosyl-(1→3)-β-D-glucopyranoside (8), hederagenin 3-O-α-L-arabinopyranoside (9), betulinic acid (10), 18-hydroxyursolic acid (11) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid (12) were isolated from the ethanolic extract of the root of Anemone tomentosa and their chemical structures were elucidated by spectroscopic methods. The antimicrobial activities of compounds 1-12 were measured using the agar disc-diffusion method. Also, their antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were evaluated.
authors.affiliation: College of Chemistry and Chemical Engineering, Longdong University, Qingyang 745000, Gansu, China. huhaobin_88@yahoo.com.cn
authors.forename: Hao-Bin
authors.initials: HB
authors.lastname: Hu
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Zheng
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Jian
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Liu
authors.forename: Ji-Hua
authors.initials: JH
authors.lastname: Zhu
mesh_terms: D031883:Anemone / Q000737:chemistry / Q000378:metabolism*; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D053978:Pentacyclic Triterpenes; D010840:Phytosterols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000094062:Betulinic Acid
chemical_list: D003374:Coumarins; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D006027:Glycosides; D053978:Pentacyclic Triterpenes; D010840:Phytosterols; D012503:Saponins; D013261:Sterols; D014315:Triterpenes; C516285:hederagenin 3-O-alpha-L-arabinopyranoside; D009828:Oleanolic Acid; D000094062:Betulinic Acid