title: Liver transplantation for acute hepatic failure due to chemotherapy-induced HBV reactivation in lymphoma patients.
abstract: Hepatitis B (HBV) reactivation induced by chemotherapy is problem encountered recently in the management of malignant diseases. Chemotherapy-induced HBV reactivation may ultimately lead to terminal acute liver failure. Liver transplantation (LT) currently remains the only definitive treatment option for such cases, but is generally denied to patients suffering from malignancy. Here, the authors describe 2 cases of cancer-free and HBV graft re-infection-free survival after LT performed for terminal liver failure arising from HBV reactivation induced by chemotherapy for advanced stage lymphoma. These 2 cases, and some other reports in the literature, may suggest that patients suffering from hematologic malignancies and terminal liver disease can be considered for LT if the prognosis of their hematologic malignancy is good.
authors.affiliation: Department of Abdominal Surgery and Transplantation, CHU de Liège, University of Liège, 4000 Liege, Belgium. tim.noterdaeme@me.com
authors.forename: Timothée
authors.initials: T
authors.lastname: Noterdaeme
authors.forename: Luc
authors.initials: L
authors.lastname: Longrée
authors.forename: Christian
authors.initials: C
authors.lastname: Bataille
authors.forename: Arnaud
authors.initials: A
authors.lastname: Deroover
authors.forename: Anne
authors.initials: A
authors.lastname: Lamproye
authors.forename: Jean
authors.initials: J
authors.lastname: Delwaide
authors.forename: Yves
authors.initials: Y
authors.lastname: Beguin
authors.forename: Pierre
authors.initials: P
authors.lastname: Honoré
authors.forename: Olivier
authors.initials: O
authors.lastname: Detry
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy* / Q000821:virology; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D017114:Liver Failure, Acute / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation; D008223:Lymphoma / Q000188:drug therapy* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D014775:Virus Activation
chemical_list: D000970:Antineoplastic Agents