title: Antifungal activity of bivittoside-D from Bohadschia vitiensis (Semper).
abstract: This study was carried out to investigate the antifungal activity of Bohadschia vitiensis Semper whole body extracts, followed by isolation and characterisation of bioactive molecules. The methanol extract of the B. vitiensis showed promising activity in in vitro models against Candida albicans, Cryptococcus neoformans, Sporothrix schenckii, Trichophyton mentagrophytes, Aspergillus fumigatus and Candida parapsilosis. The antifungal activity was found in aqueous fraction against C. albicans, C. neoformans, S. schenckii, T. mentagrophytes and A. fumigatus. The major compound was purified from the aqueous fraction and was identified as bivittoside-D isolated earlier from the animal. It showed promising results against C. neoformans, C. neoformans, S. schenckii, T. mentagrophytes, A. fumigatus and C. parapsilosis.
authors.affiliation: Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow-226001, India. vijlakshmius@yahoo.com
authors.forename: Vijai
authors.initials: V
authors.lastname: Lakshmi
authors.forename: Shishir
authors.initials: S
authors.lastname: Srivastava
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Mishra
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Shukla
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D006697:Holothurin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012616:Sea Cucumbers / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D006697:Holothurin; C043974:bivittoside D