title: Multiscale modeling for image analysis of brain tumor studies.
abstract: Image-based modeling of tumor growth combines methods from cancer simulation and medical imaging. In this context, we present a novel approach to adapt a healthy brain atlas to MR images of tumor patients. In order to establish correspondence between a healthy atlas and a pathologic patient image, tumor growth modeling in combination with registration algorithms is employed. In a first step, the tumor is grown in the atlas based on a new multiscale, multiphysics model including growth simulation from the cellular level up to the biomechanical level, accounting for cell proliferation and tissue deformations. Large-scale deformations are handled with an Eulerian approach for finite element computations, which can operate directly on the image voxel mesh. Subsequently, dense correspondence between the modified atlas and patient image is established using nonrigid registration. The method offers opportunities in atlas-based segmentation of tumor-bearing brain images as well as for improved patient-specific simulation and prognosis of tumor progression.
authors.affiliation: Institute for Surgical Technology and Biomechanics, University of Bern, Bern 3014, Switzerland. stefan.bauer@istb.unibe.ch
authors.forename: Stefan
authors.initials: S
authors.lastname: Bauer
authors.forename: Christian
authors.initials: C
authors.lastname: May
authors.forename: Dimitra
authors.initials: D
authors.lastname: Dionysiou
authors.forename: Georgios
authors.initials: G
authors.lastname: Stamatakos
authors.forename: Philippe
authors.initials: P
authors.lastname: Büchler
authors.forename: Mauricio
authors.initials: M
authors.lastname: Reyes
mesh_terms: D000465:Algorithms; D001921:Brain; D001932:Brain Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D003198:Computer Simulation; D005910:Glioma / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity