title: Saline infusion sonohysterography versus hysteroscopy for uterine cavity evaluation.
abstract: OBJECTIVE
  The most frequent procedures performed on women with abnormal uterine bleeding are 2D and 3D ultrasound. The most common accepted approach for the management of abnormal uterine bleeding is 2D TV scan followed by therapeutic hysteroscopy. The purpose of this prospective study was to assess whether 3D saline infusion sonohysterography (3D SIS) could replace diagnostic hysteroscopy (DH) for the diagnosis of endometrial pathology, in patients with abnormal uterine bleeding.
  
  
  METHODS
  A prospective study in the ultrasound department of the Women's Specialized Hospital, King Fahad Medical City, Riyadh, Saudi Arabia from January 2008 to February 2010.
  
  
  METHODS
  0One hundred and one patients with abnormal uterine bleeding, suspected to have endometrial abnormality by 2D and 3D transvaginal scan, were prospectively studied. Of these, 55 patients had undergone both 3D SIS and DH, followed by verification of results with histopathology.
  
  
  RESULTS
  Upon comparison of 3D SIS and DH individually with histopathology, specificity and sensitivity for 3D SIS were 67% and 100%, respectively, and for hysteroscopy 67% and 98%, respectively. In addition, the positive predictive value and negative predictive value were 98% and 100%, respectively, for 3D SIS, while for DH they were 98% and 67%, respectively.
  
  
  CONCLUSIONS
  3D SIS is a safe alternative to hysteroscopy. However, larger randomized controlled trials should be conducted to ascertain the validity and reliability of this advantageous, less-invasive procedure, for women with abnormal uterine bleeding, who require evaluation of the endometrial cavity.
authors.affiliation: Ultrasound Department, Women's Specialized Hospital, King Fahad Medical City, Riyadh, Saudi Arabia.
authors.forename: Faryal
authors.initials: F
authors.lastname: Khan
authors.forename: Sadia
authors.initials: S
authors.lastname: Jamaat
authors.forename: Dania
authors.initials: D
authors.lastname: Al-Jaroudi
mesh_terms: D000328:Adult; D004717:Endometrium / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D021621:Imaging, Three-Dimensional; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012965:Sodium Chloride / Q000008:administration & dosage; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000000981:diagnostic imaging* / Q000209:etiology; D014599:Uterus / Q000000981:diagnostic imaging*
chemical_list: D012965:Sodium Chloride