title: Human polyomavirus related to African green monkey lymphotropic polyomavirus.
abstract: While studying the virome of the skin surface of a patient with a Merkel cell carcinoma (MCC) by using unbiased, high-throughput sequencing, we identified a human polyomavirus nearly identical to human polyomavirus 9, a virus recently reported in blood and urine of renal transplantion patients and closely related to the African green monkey lymphotropic polyomavirus. Specific PCR analysis further identified this virus in 2/8 patients with MCC but in only 1/111 controls without MCC. This virus was shed for ≥20 months by the MCC index patient and was on the skin of the spouse of the index patient. These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders.
authors.affiliation: Institut Pasteur, Paris, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Sauvage
authors.forename: Vincent
authors.initials: V
authors.lastname: Foulongne
authors.forename: Justine
authors.initials: J
authors.lastname: Cheval
authors.forename: Meriadeg
authors.initials: M
authors.lastname: Ar Gouilh
authors.forename: Kevin
authors.initials: K
authors.lastname: Pariente
authors.forename: Olivier
authors.initials: O
authors.lastname: Dereure
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Manuguerra
authors.forename: Jennifer
authors.initials: J
authors.lastname: Richardson
authors.forename: Marc
authors.initials: M
authors.lastname: Lecuit
authors.forename: Ana
authors.initials: A
authors.lastname: Burguière
authors.forename: Valérie
authors.initials: V
authors.lastname: Caro
authors.forename: Marc
authors.initials: M
authors.lastname: Eloit
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D015266:Carcinoma, Merkel Cell / Q000821:virology*; D002522:Chlorocebus aethiops / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis / Q000302:isolation & purification; D005260:Female; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008297:Male; D018862:Merkel Cells / Q000821:virology; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011120:Polyomavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D027601:Polyomavirus Infections / Q000821:virology; D017422:Sequence Analysis, DNA; D012867:Skin / Q000821:virology*; D012878:Skin Neoplasms / Q000821:virology*; D014412:Tumor Virus Infections / Q000821:virology; D055815:Young Adult
chemical_list: D004279:DNA, Viral