title: Palladium-catalyzed direct 2-alkylation of indoles by norbornene-mediated regioselective cascade C-H activation.
abstract: A palladium-catalyzed direct 2-alkylation reaction of free N-H indoles has been developed. This reaction relies on a norbornene-mediated cascade C-H activation process at the indole ring, which features high regioselectivity and excellent functional group tolerance. The reaction represents the first example for a generally applicable, direct C-H alkylation of indole at the 2-position.
authors.affiliation: Lehrstuhl für Organische Chemie I and Catalysis Research Center (CRC), Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.
authors.forename: Lei
authors.initials: L
authors.lastname: Jiao
authors.forename: Thorsten
authors.initials: T
authors.lastname: Bach
mesh_terms: D000478:Alkylation; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D009636:Norbornanes / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
chemical_list: D007211:Indoles; D009636:Norbornanes; D010165:Palladium