title: Role of p53 within the regulatory network controlling muscle mitochondrial biogenesis.
abstract: The tumor suppressor protein p53 is recognized to contribute significantly to the regulation of mitochondrial content. Mice without p53 have reduced endurance capacity and muscle performance. However, the function of p53 in muscle remains to be fully established. Understanding how p53 coordinates mitochondrial homeostasis will facilitate a better comprehension of how exercise could constitute as a therapy for cancer treatment.
authors.affiliation: School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada.
authors.forename: Ayesha
authors.initials: A
authors.lastname: Saleem
authors.forename: Heather N
authors.initials: HN
authors.lastname: Carter
authors.forename: Sobia
authors.initials: S
authors.lastname: Iqbal
authors.forename: David A
authors.initials: DA
authors.lastname: Hood
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001343:Autophagy; D015444:Exercise; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D009369:Neoplasms / Q000628:therapy*; D058570:TOR Serine-Threonine Kinases / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: D016159:Tumor Suppressor Protein p53; D058570:TOR Serine-Threonine Kinases