title: Non-steroidal antiinflammatory drug-copper(II) complexes: structure and biological perspectives.
abstract: Copper(II) complexes with the non-steroidal antiinflammatory drug mefenamic acid in the presence of aqua or nitrogen donor heterocyclic ligands (2,2'-bipyridine, 1,10-phenanthroline, 2,2'-bipyridylamine or pyridine) have been synthesized and characterized. The crystal structures of [(2,2'-bipyridine)bis(mefenamato)copper(II)], 2, [(2,2'-bipyridylamine)bis(mefenamato)copper(II)], 4, and [bis(pyridine)bis(methanol)bis(mefenamato)copper(II)], 5, have been determined by X-ray crystallography. UV study of the interaction of the complexes with calf-thymus DNA (CT DNA) has shown that the complexes can bind to CT DNA and [bis(aqua)tetrakis(mefenamato)dicopper(II)] exhibits the highest binding constant to CT DNA. The cyclic voltammograms of the complexes in the presence of CT DNA solution have shown that the complexes can bind to CT DNA by the intercalative binding mode verified also by DNA solution viscosity measurements. Competitive studies with ethidium bromide (EB) indicate that the complexes can displace the DNA-bound EB suggesting strong competition with EB. Mefenamic acid and its complexes exhibit good binding propensity to human or bovine serum albumin protein having relatively high binding constant values. All the compounds have been tested for their antioxidant and free radical scavenging activity as well as for their in vitro inhibitory activity against soybean lipoxygenase showing significant activity.
authors.affiliation: Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, P.O. Box 135, GR-54124, Thessaloniki, Greece.
authors.forename: Filitsa
authors.initials: F
authors.lastname: Dimiza
authors.forename: Stella
authors.initials: S
authors.lastname: Fountoulaki
authors.forename: Athanasios N
authors.initials: AN
authors.lastname: Papadopoulos
authors.forename: Christos A
authors.initials: CA
authors.lastname: Kontogiorgis
authors.forename: Vassilis
authors.initials: V
authors.lastname: Tangoulis
authors.forename: Catherine P
authors.initials: CP
authors.lastname: Raptopoulou
authors.forename: Vassilis
authors.initials: V
authors.lastname: Psycharis
authors.forename: Aris
authors.initials: A
authors.lastname: Terzis
authors.forename: Dimitris P
authors.initials: DP
authors.lastname: Kessissoglou
authors.forename: George
authors.initials: G
authors.lastname: Psomas
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D000975:Antioxidants; D002417:Cattle; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000378:metabolism; D016166:Free Radical Scavengers; D006801:Humans; D008024:Ligands; D016859:Lipoxygenase Inhibitors; D008528:Mefenamic Acid / Q000737:chemistry; D015394:Molecular Structure; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D016166:Free Radical Scavengers; D008024:Ligands; D016859:Lipoxygenase Inhibitors; D012709:Serum Albumin; D008528:Mefenamic Acid; D003300:Copper; D004247:DNA