title: Yojironins E-I, prenylated acylphloroglucinols from Hypericum yojiroanum.
abstract: Five new prenylated acylphloroglucinols, yojironins E-Ι (1-5), were isolated from the whole plants of Hypericum yojiroanum. Their structures were elucidated by spectroscopic data. Yojironin E (1) exhibited antimicrobial activity against Aspergillus niger, Candida albicans, Cryptococcus neoformans, and Trichophyton mentagrophytes.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Naonobu
authors.initials: N
authors.lastname: Tanaka
authors.forename: Takuji
authors.initials: T
authors.lastname: Mamemura
authors.forename: Azusa
authors.initials: A
authors.lastname: Shibazaki
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D003455:Cryptococcus neoformans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D010696:Phloroglucinol