title: Effect of propetamphos on the male rats reproductive system.
abstract: The present study aimed at defining the testicular toxicity of propetamphos. Mature male albino rats (5-6 months old) were treated with propetamphos orally at doses of 0, 0.18, 0.38, 0.75, 1.5 and 3mg/kg/day for 60 consecutive days. Propetamphos at a dose of 0.38 mg/kg/day significantly reduced the sperm motility only. At 0.75 mg/kg/day sperm count, sperm motility, plasma testosterone level and activity of sorbiol dehydrogenase (SDH) were significantly reduced and sperm morphological abnormalities were significantly increased. At 1.5mg/kg/day weight of testes, seminal vesicle and epididymis were reduced dose dependently whereas, at 3mg/kg/day, weight of prostate gland and activities of acid phosphatase (ACP) and glucose-6-P-dehydrogenase (G6PDH) were decreased significantly. On histopathological examination indicated toxicity of propetamphos on testes depending on dose and observed at doses higher than 0.38 mg/kg/day. These results indicate testicular toxicity of propetamphos at dose of 0.38 mg/kg/day or higher in male albino rats.
authors.affiliation: Department of Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine and Animal Resources King Faisal University, Postal Code 1757, Al Ahsa 31982, Saudi Arabia. m ism@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Ismail
authors.forename: A Y
authors.initials: AY
authors.lastname: Al-Taher
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005837:Genitalia, Male / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology / Q000502:physiology
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; D007064:L-Iditol 2-Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D000135:Acid Phosphatase; C035967:propetamphos