title: [Prognostic value of metastatic lymph node ratio for patients with gastric cancer].
abstract: OBJECTIVE
  To evaluate the prognostic value of metastatic lymph node ratio (MLR) for patients with gastric cancer.
  
  
  METHODS
  Data collected from 1247 patients with gastric cancer who underwent radical surgery (pT4 cases were excluded) at the First Affiliated Hospital of Nanjing Medical University between 2005 and 2009 were analyzed retrospectively. MLR was compared to pathological N staging (pN) in terms of prognostic accuracy, homogenicity, and applicability.
  
  
  RESULTS
  MLR and pN were both positively correlated with the number of retrieved lymph nodes(both P<0.01). Significant differences were found in 5-year cumulative survival rate (5-YCSR) among different pN stages and MLR classification(all P<0.01). Multivariable analysis showed that both pN and MLR were independent prognostic factors(both P<0.01). The area under ROC curve(AUC) of MLR was larger than pN, however the difference was not statistically significant(P>0.05). There were significant differences in 5-YCSR among different MLR stages within the same pN stages(P<0.05), but not among different pN stages within the same MLR stage(P>0.05). Significant differences in 5-YCSR were also found among different retrieved-node groups within the same pN stage (P<0.05), but not within the same MLR stages (P>0.05).
  
  
  CONCLUSIONS
  MLR is an independent prognostic factor for patients with gastric cancer. The prognostic homogenicity and applicability of MLR are better than those of pN, however the prediction accuracy is not favorable.
authors.affiliation: Department of Oncology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China. liu-ping@csco.org.cn.
authors.forename: Cun-jun
authors.initials: CJ
authors.lastname: Yu
authors.forename: Wen-ting
authors.initials: WT
authors.lastname: He
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.forename: Yong-qian
authors.initials: YQ
authors.lastname: Shu
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology*