title: [Bioluminescence in-vivo imaging technology and its application in the study of viral infection--a review].
abstract: Bioluminescence imaging is one of the bio-optical imaging techniques which report definite biological event in living animals with genetic modification. With high sensitivity, simple operation and high precision, it is particularly applied in observing vital processes like viral infection and tumor growth in vivo. We summarize the principle of bioluminescence imaging, introduce its application in finding virus replication site, study of interferon (IFN) inhibiting-virus effect and real-time visualization of viral latent infection and reactivation, and preview the trend of bioluminescence imaging technological development.
authors.affiliation: State Key Laboratory of Virology, Institute of Virology, Chinese Academy of Science, Wuhan 430071, China. shaka@126.com
authors.forename: Fan
authors.initials: F
authors.lastname: Chai
authors.forename: Yunyi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Gengfu
authors.initials: G
authors.lastname: Xiao
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D014777:Virus Diseases / Q000175:diagnosis* / Q000821:virology; D014780:Viruses / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D008164:Luminescent Proteins