title: Ascending aortic aneurysm and aortic valve dysfunction in bicuspid aortic valve disease.
abstract: BACKGROUND
  The relationship of aortic valve dysfunction and ascending aortic aneurysm is unclear in adults with bicuspid aortic valve disease.
  
  
  METHODS
  We retrospectively studied 134 consecutive out-patients (98 men, 36 women aged 43 ± 18 years) with bicuspid aortic valve disease. To investigate the relationship of ascending aortic aneurysm and aortic valve dysfunction we exclusively considered severe pathologies that required treatment by surgical or percutaneous intervention.
  
  
  RESULTS
  Of 134 patients, 39 had aortic valve dysfunction without concomitant ascending aortic aneurysm which had been treated previously with isolated valve surgery or percutaneous valvuloplasty comprising 25 patients with aortic stenosis (19%) and 14 patients with aortic regurgitation (10%). Conversely, 26 patients had ascending aortic aneurysm which had been treated previously with aortic surgery (19%). Of these, ascending aortic aneurysm was associated with severe aortic stenosis in 13 patients and with severe aortic regurgitation in 7 patients, whereas aneurysm was unrelated to severe aortic valve dysfunction in the remaining 6 patients including 2 without any degree of aortic valve dysfunction. The maximal aortic diameters were similar at the time of aortic surgery irrespective of presence of severe aortic valve dysfunction (P=.527). Other characteristics of patients with ascending aortic aneurysm were also similar irrespective of presence or type of aortic valve dysfunction.
  
  
  CONCLUSIONS
  The majority of patients with bicuspid aortic valve disease exhibit ascending aortic aneurysm in conjunction with severe aortic valve dysfunction. However, in our study 6 of 134 (5%) of persons with bicuspid aortic valve disease developed ascending aortic aneurysm without aortic valve dysfunction.
authors.affiliation: Centre of Cardiology and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany.
authors.forename: Ali
authors.initials: A
authors.lastname: Aydin
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Desai
authors.forename: Alexander M J
authors.initials: AM
authors.lastname: Bernhardt
authors.forename: Hendrik
authors.initials: H
authors.lastname: Treede
authors.forename: Christian
authors.initials: C
authors.lastname: Detter
authors.forename: Sara
authors.initials: S
authors.lastname: Sheikhzadeh
authors.forename: Meike
authors.initials: M
authors.lastname: Rybczynski
authors.forename: Mathias
authors.initials: M
authors.lastname: Hillebrand
authors.forename: Victoria
authors.initials: V
authors.lastname: Lorenzen
authors.forename: Kai
authors.initials: K
authors.lastname: Mortensen
authors.forename: Peter N
authors.initials: PN
authors.lastname: Robinson
authors.forename: Jürgen
authors.initials: J
authors.lastname: Berger
authors.forename: Hermann
authors.initials: H
authors.lastname: Reichenspurner
authors.forename: Thomas
authors.initials: T
authors.lastname: Meinertz
authors.forename: Stephan
authors.initials: S
authors.lastname: Willems
authors.forename: Yskert
authors.initials: Y
authors.lastname: von Kodolitsch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001011:Aorta / Q000601:surgery; D001014:Aortic Aneurysm / Q000150:complications* / Q000601:surgery*; D001021:Aortic Valve / Q000002:abnormalities / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000150:complications* / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000601:surgery*; D063126:Balloon Valvuloplasty; D000082882:Bicuspid Aortic Valve Disease; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult