title: Plasma IL-6 levels during arm exercise in persons with spinal cord injury.
abstract: METHODS
  Non-randomized study.
  
  
  OBJECTIVE
  Previous studies indicated that at least 2-h leg exercise at more than 60% maximum oxygen consumption (VO(2)max) increased plasma interleukin (IL)-6 in able-bodied (AB) subjects. The purpose of the present study was to compare IL-6 response to arm exercise in AB subjects and persons with spinal cord injury (SCI).
  
  
  METHODS
  Wakayama Medical University in Japan.
  
  
  METHODS
  Six subjects with SCI between T6 and T10 and seven AB subjects performed 2-h arm crank ergometer exercise at 60%VO(2)max. Plasma catecholamines, IL-6, tumor necrosis factor (TNF)-α and high-sensitivity C-reactive protein (hsCRP) were measured before exercise, 60-min exercise, immediately and 2 h after the completion of exercise.
  
  
  RESULTS
  Arm exercise increased myoglobin and plasma IL-6 levels in SCI and AB (P<0.01), but there were no differences in them between the two groups throughout the study. Plasma levels creatine kinase, lactate dehydrogenase, TNF-α and hsCRP did not change throughout the study in both groups.
  
  
  CONCLUSIONS
  These findings suggest neither significant muscle damage nor inflammatory response during exercise. The increase in plasma IL-6 in SCI was not unexpected, confirming that moderate intensity and relatively long-arm exercise is safe and beneficial for SCI subjects with regard to IL-6 excretion, as in AB subjects.
authors.affiliation: Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Umemoto
authors.forename: K
authors.initials: K
authors.lastname: Furusawa
authors.forename: K
authors.initials: K
authors.lastname: Kouda
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
authors.forename: N
authors.initials: N
authors.lastname: Kanno
authors.forename: D
authors.initials: D
authors.lastname: Kojima
authors.forename: F
authors.initials: F
authors.lastname: Tajima
mesh_terms: D000328:Adult; D001132:Arm / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D013119:Spinal Cord Injuries / Q000097:blood*
chemical_list: D015850:Interleukin-6