title: Preoperative use of granisetron plus dexamethasone and granisetron alone in prevention of post operative nausea and vomiting in tonsillectomy.
abstract: This prospective study was done for to see the efficacy of preoperative use of granisetron plus dexamethasone (Group A) & granisetron (Group B) alone for the postoperative prevention of nausea & vomiting after tonsillectomy operation. One hundred patients undergoing tonsillectomy & adenoidectomy operation under general anaesthesia who were admitted in the Mymensingh Medical College Hospital during the period from July 2008 to June 2009 with American Society of Anaesthesiologists (ASA) grade I & II with age 3-40 years, body weight 10-60 kgs, were studied. Observation of this study was analyzed in the light of comparison between the two groups. All results were expressed as mean±SEM. Age in Group A 15.98±1.028 & Group B 17.18±0.961 years; Weight in Group A 38.40±1.492 & Group B 39.76±1.561 kgs and operational duration in Group A 52.60±0.786 & Group B 52.70±0.823 minutes. The studied groups were statistically matched for age, weight, duration of surgery. We observed that the effects of combination of granisetron & dexamthasone are more than granisetron alone in prevention of nausea & vomiting after tonsillectomy operation. The frequency of vomiting was 4% in combination & 16% in single therapy which is statically significant (p<0.05).
authors.affiliation: Department of Anaesthesiology & Intensive Care, Mymensingh Medical College & Hospital, Mymensingh, Bangladesh.
authors.forename: M R
authors.initials: MR
authors.lastname: Islam
authors.forename: M F
authors.initials: MF
authors.lastname: Haq
authors.forename: M A
authors.initials: MA
authors.lastname: Islam
authors.forename: S M
authors.initials: SM
authors.lastname: Meftahuzzaman
authors.forename: S C
authors.initials: SC
authors.lastname: Sarkar
authors.forename: H
authors.initials: H
authors.lastname: Rashid
authors.forename: H U
authors.initials: HU
authors.lastname: Rashid
mesh_terms: D000233:Adenoidectomy / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D000932:Antiemetics / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D017829:Granisetron / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D020250:Postoperative Nausea and Vomiting / Q000209:etiology / Q000517:prevention & control*; D014068:Tonsillectomy / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000932:Antiemetics; D003907:Dexamethasone; D017829:Granisetron