title: [Genome-wide association study of allergic diseases in Russians of Western Siberia].
abstract: Genome-wide association studies are currently considered as one of the most powerful tools to establishing the genetic basis of complex diseases. A number of such studies were carried out for allergic diseases; however, in Russian population this analysis has not been performed so far. For the first time, we performed genome-wide association study of allergic diseases in Russian inhabitants of Western Siberia. Two new loci associated with childhood bronchial asthma were identified (20q13.12, rs2425656, P = 1.99 x 10(-7); 1q32.1, rs3817222, rs12734001, P = 2.18 x 10(-7) and 2.79 x 10(-7), respectively) as well as one locus, associated with allergic rhinitis (2q36.1, rs1597167, P = 3.69 x 10(-7)). Genes located in the loci, YWHAB and PPP1R12B for asthma and KCNE4 for allergic rhinitis, are new genes for these diseases. It was found that BAT1 (6p21.33), MAGI2 (7q21.11) and ACPL2 (3q23) genes are, likely, common (syntropic) genes of allergic disease and a topic sensitisation. It was shown that RIT2 (18q12.3) and (5q31.1) genes can be involved in the control of lung function. The results of the study enlarge the body of data on genetic factors of allergy and expand the list of genes underlying these diseases.
authors.forename: M B
authors.initials: MB
authors.lastname: Freĭdin
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Bragina
authors.forename: O S
authors.initials: OS
authors.lastname: Fedorova
authors.forename: I A
authors.initials: IA
authors.lastname: Deev
authors.forename: E S
authors.initials: ES
authors.lastname: Kulikov
authors.forename: L M
authors.initials: LM
authors.lastname: Ogorodova
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
mesh_terms: D048948:14-3-3 Proteins / Q000235:genetics; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D043263:Myosin-Light-Chain Phosphatase / Q000235:genetics; D010375:Pedigree; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*; D012800:Siberia / Q000208:ethnology; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: D048948:14-3-3 Proteins; C498897:KCNE4 protein, human; D024642:Potassium Channels, Voltage-Gated; C482982:YWHAB protein, human; D043263:Myosin-Light-Chain Phosphatase