title: HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits.
abstract: Familial hypercholesterolemia (FH) is an autosomal codominant disease characterized by high concentrations of proatherogenic lipoproteins secondary to deficiency in low-density lipoprotein (LDL) receptor. We reported recently the use of in situ stem cell therapy of human adipose tissue-derived multilineage progenitor cells (hADMPCs) in lowering serum total cholesterol in the homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model of homozygous FH. Here we demonstrate that pravastatin, an HMG-CoA reductase inhibitor, augmented the cholesterol-lowering effect of transplanted hADMPCs and enhanced LDL clearance in homozygous WHHL rabbit. The results suggest the potential beneficial effects of in situ stem cell therapy in concert with appropriately selected pharmaceutical agents, in regenerative medicine.
authors.affiliation: Department of Somatic Stem Cell Therapy and Health Policy, Foundation for Biomedical Research and Innovation, TRI305, Kobe, Hyogo 650-0047, Japan.
authors.forename: Ayami
authors.initials: A
authors.lastname: Saga
authors.forename: Hanayuki
authors.initials: H
authors.lastname: Okura
authors.forename: Mayumi
authors.initials: M
authors.lastname: Soeda
authors.forename: Junko
authors.initials: J
authors.lastname: Tani
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Fumimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Komoda
authors.forename: Mariko
authors.initials: M
authors.lastname: Moriyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Moriyama
authors.forename: Shizuya
authors.initials: S
authors.lastname: Yamashita
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ichinose
authors.forename: Takashi
authors.initials: T
authors.lastname: Daimon
authors.forename: Takao
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Akifumi
authors.initials: A
authors.lastname: Matsuyama
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000328:Adult; D000818:Animals; D019070:Cell Lineage / Q000187:drug effects; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D006938:Hyperlipoproteinemia Type II / Q000601:surgery*; D008875:Middle Aged; D017035:Pravastatin / Q000494:pharmacology*; D011817:Rabbits; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000187:drug effects* / Q000502:physiology; D055815:Young Adult
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol; D017035:Pravastatin