title: New potential antiscarring approaches.
abstract: Significant progress has been made in scar research in which an anti-transforming growth factor-β strategy has already been translated from an experimental study to a clinical trial. However, scar reduction and elimination remain an unmet medical need because of the difficulty in its treatment. The authors of this article would like to propose several new potential antiscarring approaches for scar prevention including anti-transforming growth factor-β, multifactor therapies, tissue regeneration, and tissue-engineered skin. In addition, scar remodeling is also proposed as an alternative new potential approach for scar therapy. We hope that some of these potential approaches might be translated into clinical scar therapies in the near future.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liuwei_2000@yahoo.com
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D009389:Neovascularization, Pathologic; D012038:Regeneration / Q000502:physiology; D012867:Skin / Q000196:embryology* / Q000473:pathology; D023822:Tissue Engineering; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D016212:Transforming Growth Factor beta