title: [Induction therapy of locally-advanced nasophayngeal cancer].
abstract: Unlike most head and neck tumors, nasophayngeal cancer (NPC) is characterized by such ep-idemiological and histological features as massive lympho- and hematogenic metastasizing and enhanced sensitivity to conservative therapy. More than 80% of diagnosed tumors are grade III-IV and, therefore, are more resistant to irradiation; they have a worse prognosis. Our method of induction chemotherapy (docetaxel, doxorubicin, cisplatin) was used in treating 50 patients with locally-advanced NPC: complete response--88% (44) [complete resorption--48% (24)]. Lymphadenectomy was carried out in 12 cases of primary metastatic lesions N2-3 in the elymph nodes of the neck on completion of all stages of combined (induction + radiation) therapy. Metastases to the regional lymph nodes were detected in 10 patients.
authors.forename: L V
authors.initials: LV
authors.lastname: Bolotina
authors.forename: A L
authors.initials: AL
authors.lastname: Kornietskaia
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D000077143:Docetaxel; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D010610:Pharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D004317:Doxorubicin; D002945:Cisplatin