title: Helminth infections: therapeutic potential in autoimmune disorders.
abstract: Knowledge of immunity enables us to predict that the reactions set in response to infection with helminth would prevent concomitant disease driven by an opposing spectrum of immune events. In another way, the immune response generated to combat the helminth infection could counteract the immunopathological reactions that drive autoimmune diseases. Rodent model systems recapitulate many aspects of human autoimmune diseases and have been enormously useful in defining mechanisms of immunopathology after infection. From this theoretical perspective, many researchers have proved that infection with a variety of helminth can ameliorate disease in murine model systems. Thus, helminth-evoked Th2 events were shown to improve disorders in which Th1 events predominated. This raised the question, 'Can this information be translated into therapies for autoimmune diseases in humans via actual infection, cell delivery or drug intervention?' In this review, we will present some experimental trails to treat autoimmune disorders through establishment of some parasitic infections.
authors.affiliation: Departments of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. malky197@mans.edu.eg
authors.forename: M
authors.initials: M
authors.lastname: El-Malky
authors.forename: N
authors.initials: N
authors.lastname: Nabih
authors.forename: M
authors.initials: M
authors.lastname: Heder
authors.forename: N
authors.initials: N
authors.lastname: Saudy
authors.forename: M
authors.initials: M
authors.lastname: El-Mahdy
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000517:prevention & control* / Q000628:therapy*; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D006373:Helminthiasis / Q000276:immunology* / Q000469:parasitology; D006790:Host-Parasite Interactions; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000276:immunology / Q000469:parasitology; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D061147:Therapy with Helminths
chemical_list: D016207:Cytokines