title: Genetic association of complement receptor 1 polymorphism rs3818361 in Alzheimer's disease.
abstract: Complement receptor 1 gene polymorphism rs3818361 was recently shown to increase the risk of Alzheimer's disease (AD). We performed an independent replication study of this genetic variant in 2,470 individuals from Spain. By applying an allelic model, we observed a trend toward an association between this marker and late-onset AD susceptibility in our case-control study (odds ratio = 1.114, 95% confidence interval: 0.958-1.296, P = .16). Meta-analysis of available studies (n = 31,771 individuals), including previous studies and public genome-wide association study resources (Alzheimer's Disease Neuroimaging Initiative, Translational Genomics Research Institute, and Multi-site Collaborative Study for Genotype-Phenotype Associations in Alzheimer's Disease), strongly supports the effect of rs3818361 (odds ratio = 1.180, 95% confidence interval: 1.113-1.252, P < 2.99E-8) and suggests the existence of between-study heterogeneity (P < .05). We concluded that the complement receptor 1 gene may contribute to AD risk, although its effect size could be smaller than previously estimated.
authors.affiliation: Dementia Unit, University Hospital Virgen de la Arrixaca, Murcia, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Antúnez
authors.forename: Mercè
authors.initials: M
authors.lastname: Boada
authors.forename: Jesús
authors.initials: J
authors.lastname: López-Arrieta
authors.forename: Concha
authors.initials: C
authors.lastname: Moreno-Rey
authors.forename: Isabel
authors.initials: I
authors.lastname: Hernández
authors.forename: Juan
authors.initials: J
authors.lastname: Marín
authors.forename: Javier
authors.initials: J
authors.lastname: Gayán
authors.forename: Antonio
authors.initials: A
authors.lastname: González-Pérez
authors.forename: Luis M
authors.initials: LM
authors.lastname: Real
authors.forename: Montserrat
authors.initials: M
authors.lastname: Alegret
authors.forename: Lluis
authors.initials: L
authors.lastname: Tárraga
authors.forename: Reposo
authors.initials: R
authors.lastname: Ramírez-Lorca
authors.forename: Agustín
authors.initials: A
authors.lastname: Ruiz
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011951:Receptors, Complement / Q000235:genetics*; D013030:Spain
chemical_list: D011951:Receptors, Complement