title: Neuropeptides and enzymes are targets for the action of endocrine disrupting chemicals in the vertebrate brain.
abstract: Endocrine-disrupting chemicals (EDC) are molecules that interfere with endocrine signaling pathways and produce adverse consequences on animal and human physiology, such as infertility or behavioral alterations. Some EDC act through binding to androgen or/and estrogen receptors primarily operating through a genomic mechanism regulating gene expression. This mechanism of action may induce profound developmental adverse effects, and the major targets of the EDC action are the gene products, i.e., mRNAs inducing the synthesis of various peptidic molecules, which include neuropeptides and enzymes related to neurotransmitters syntheses. Available immunohistochemical data on some of the systems that are affected by EDC in lower and higher vertebrates are detailed in this review.
authors.affiliation: Laboratory of Neuroendocrinology, Department of Anatomy, Pharmacology, and Forensic Medicine, Neuroscience Institute of Turin (NIT), University of Torino, Torino, Italy. giancarlo.panzica@unito.it
authors.forename: G C
authors.initials: GC
authors.lastname: Panzica
authors.forename: E
authors.initials: E
authors.lastname: Bo
authors.forename: M A
authors.initials: MA
authors.lastname: Martini
authors.forename: D
authors.initials: D
authors.lastname: Miceli
authors.forename: E
authors.initials: E
authors.lastname: Mura
authors.forename: C
authors.initials: C
authors.lastname: Viglietti-Panzica
authors.forename: S
authors.initials: S
authors.lastname: Gotti
mesh_terms: D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D004798:Enzymes / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D009479:Neuropeptides / Q000187:drug effects / Q000378:metabolism; D011485:Protein Binding; D012333:RNA, Messenger / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D004798:Enzymes; D009479:Neuropeptides; D012333:RNA, Messenger; D011944:Receptors, Androgen; D011960:Receptors, Estrogen