title: Mechanisms of olive leaf extract-ameliorated rat arthritis caused by kaolin and carrageenan.
abstract: Olive leaf extract (OLE) has antioxidant and antiinflammatory actions. However, the role of OLE in mechanical inflammatory arthritis (osteoarthritis, OA) is unclear. This study investigated the effect of OLE on the development of kaolin and carrageenan-induced arthritis, a murine model of OA. Administration of OLE significantly ameliorated paw swelling, the paw Evans blue content and the histopathological scores. In the human monocyte cell line, THP-1, the OLE reduced the LPS-induced TNF-α production and was dose dependent. Croton oil-induced ear edema in mice also revealed that treatment with OLE suppressed ear edema, myeloperoxidase (MPO) production and was dose dependent. These results indicated that OLE is an effective antiarthritis agent through an antiinflammation mechanism. Also OLE may be beneficial for the treatment of OA in humans.
authors.affiliation: China-Japanese Joint Institute for Medical and Pharmaceutical Science, Dalian Medical University, No. 9, West Segment of South Lvshun Road, Dalian 116044, China.
authors.forename: Dezheng
authors.initials: D
authors.lastname: Gong
authors.forename: Chengyan
authors.initials: C
authors.lastname: Geng
authors.forename: Liping
authors.initials: L
authors.lastname: Jiang
authors.forename: Lihui
authors.initials: L
authors.lastname: Wang
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshimura
authors.forename: Laifu
authors.initials: L
authors.lastname: Zhong
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002351:Carrageenan / Q000009:adverse effects*; D045744:Cell Line, Tumor; D003436:Croton Oil / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D005070:Evans Blue / Q000737:chemistry; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007616:Kaolin / Q000009:adverse effects*; D008070:Lipopolysaccharides / Q000009:adverse effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D031658:Olea / Q000737:chemistry*; D009195:Peroxidase / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D007616:Kaolin; D005070:Evans Blue; D003436:Croton Oil; D002351:Carrageenan; D009195:Peroxidase