title: Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians.
abstract: BACKGROUND
  A single-nucleotide polymorphism Trp719Arg (rs20455T>C) in the kinesin-like protein 6 (KIF6), which is a protein involved in intracellular transport, has been shown to predict increased coronary artery disease (CAD) risk and event reduction during statin therapy.
  
  
  OBJECTIVE
  In the current study, we have evaluated the association of the variant Trp719Arg with CAD/non fatal myocardial infarction (MI) in Western Indians.
  
  
  METHODS
  Genotyping for Trp719Arg was done by an allele-specific real-time assay in 227 cases with confirmed CAD and 150 controls.
  
  
  RESULTS
  We have found that the KIF6 719 Arg carriers were not at a significantly higher risk for CAD/non-fatal MI in this case-control study of an Indo-European population from Western India (Unadjusted odds ratio [OR] 0.767 95% confidence interval [CI] 0.573-1.027 for 719Arg carriers). When the genotypes were further tested to determine association with prevalent myocardial infarction as the event versus CAD, no association was seen in a univariate analysis (MI vs. CAD OR 0.804 95% CI 0.543-1.189; MI vs. Controls OR 0.702 95% CI 0.482-1.021).
  
  
  CONCLUSIONS
  In summary, carriers of the KIF6 719Arg allele were not at increased risk of CAD/non-fatal MI in a case-control study of Indians (Indo-Europeans) living in Western India.
authors.affiliation: Research and Development, Super Religare Laboratories Ltd., S.V Road, Goregaon (W), Mumbai, India.
authors.forename: Aparna A
authors.initials: AA
authors.lastname: Bhanushali
authors.forename: Aashish
authors.initials: A
authors.lastname: Contractor
authors.forename: Vijay T
authors.initials: VT
authors.lastname: Shah
authors.forename: Bibhu R
authors.initials: BR
authors.lastname: Das
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007194:India; D016547:Kinesins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: C526774:KIF6 protein, human; D016547:Kinesins