title: A "diels-alderase" at last.
abstract: Diels this Alder your thinking? Electrocyclization reactions are exceedingly rare in metabolic pathways. Why is this so? Recently a [4+2] cycloaddition catalyzed by a monofunctional "Diels-Alderase" has been characterized. How does a 500-fold rate enhancement shown by this enzyme stack up?
authors.affiliation: Department of Chemistry, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA. ctownsend@jhu.edu
authors.forename: Craig A
authors.initials: CA
authors.lastname: Townsend
mesh_terms: D055162:Biocatalysis; D002826:Chorismate Mutase / Q000378:metabolism; D061565:Cycloaddition Reaction / Q000379:methods*; D003509:Cyclohexanecarboxylic Acids / Q000378:metabolism; D053138:Cyclohexenes / Q000378:metabolism; D008780:Methyltransferases / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000378:metabolism
chemical_list: D003509:Cyclohexanecarboxylic Acids; D053138:Cyclohexenes; D012436:S-Adenosylmethionine; D008780:Methyltransferases; D002826:Chorismate Mutase; C005550:prephenic acid