title: Pilot study on clinical effectiveness of autofluorescence imaging for early gastric cancer diagnosis by less experienced endoscopists.
abstract: This study aimed to assess and compare effectiveness of Autofluorescence imaging (AFI) in diagnosis of early gastric cancer (EGC) between experienced and less experienced endoscopists. Fifty selected images (20 neoplastic lesions and 30 benign lesions/areas) of both white light endoscopy (WLE) and AFI were blindly reviewed by two groups; first consisted of five experienced endoscopists and second included five less experienced endoscopists. Sensitivity, specificity, and accuracy were 70%, 78%, and 75%, respectively, for AFI and 81%, 76%, and 78%, respectively, for WLE in the experienced group. In the less experienced group, sensitivity, specificity and accuracy were 80%, 81% and 80%, respectively, for AFI and 65%, 77%, and 72%, respectively, for WLE. Interobserver variability for the less experienced group was better with AFI than WLE. AFI improved sensitivity of endoscopic diagnosis of neoplastic lesions by less experienced endoscopists, and its use could beneficially enhance the clinical effectiveness of EGC screening.
authors.affiliation: Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tada
authors.forename: Ichiro
authors.initials: I
authors.lastname: Oda
authors.forename: Chizu
authors.initials: C
authors.lastname: Yokoi
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Taku
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Suzuki
authors.forename: Satoru
authors.initials: S
authors.lastname: Nonaka
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Yoshinaga
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saito
authors.forename: Takuji
authors.initials: T
authors.lastname: Gotoda