title: Intracerebroventricular administration of vasoactive intestinal peptide inhibits food intake.
abstract: Vasoactive intestinal peptide (VIP) is a 28 amino acid peptide expressed throughout the peripheral and central nervous systems. VIP and the VIP receptor VPAC(2)R are expressed in hypothalamic nuclei involved in the regulation of energy homeostasis. VIP has been shown to be involved in the regulation of energy balance in a number of non-mammalian vertebrates. We therefore examined the effects of intracerebroventricular (ICV) administration of VIP on food intake, energy expenditure and activity in adult male Wistar rats. VIP administration caused a potent short lived decrease in food intake and an increase in activity and energy expenditure. The pathways potentially involved in the anorexigenic effects of VIP were investigated by measuring the release of neuropeptides involved in the regulation of food intake from hypothalamic explants treated with VIP. VIP significantly stimulated the release of the anorexigenic peptide alpha-melanocyte stimulating hormone (αMSH). These studies suggest that VIP may have an endogenous role in the hypothalamic control of energy homeostasis.
authors.affiliation: Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Du Cane Road, London, W12 0NN, UK. s.ghourab06@imperial.ac.uk
authors.forename: Samar
authors.initials: S
authors.lastname: Ghourab
authors.forename: Kylie E
authors.initials: KE
authors.lastname: Beale
authors.forename: Nina M
authors.initials: NM
authors.lastname: Semjonous
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Simpson
authors.forename: Niamh M
authors.initials: NM
authors.lastname: Martin
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Ghatei
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Bloom
authors.forename: Kirsty L
authors.initials: KL
authors.lastname: Smith
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D004734:Energy Metabolism / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage* / Q000494:pharmacology*
chemical_list: C103272:SHU 9119; D014660:Vasoactive Intestinal Peptide; D009074:Melanocyte-Stimulating Hormones