title: Evidence for network evolution in an Arabidopsis interactome map.
abstract: Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.
authors.affiliation: Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D019143:Evolution, Molecular; D017343:Genes, Plant; D010937:Plant Growth Regulators / Q000378:metabolism; D025941:Protein Interaction Mapping; D020543:Proteome; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D048948:14-3-3 Proteins; D029681:Arabidopsis Proteins; D010937:Plant Growth Regulators; D020543:Proteome; D014157:Transcription Factors