title: Serum selenium levels do not differ in type 2 diabetic subjects with and without coronary artery disease.
abstract: BACKGROUND
  The aim of the present study was to investigate whether selenium levels differ between type 2 diabetic subjects with and without coronary artery disease (CAD).
  
  
  METHODS
  A total of 200 subjects with type 2 diabetes (100 with CAD and 100 without CAD), consecutively selected from the diabetes outpatient clinic of our hospital were enrolled into the study. A detailed medical history and a physical examination were obtained by all the participants.
  
  
  RESULTS
  Serum selenium levels did not differ between diabetic subjects with and without CAD (102.40 ± 31.10 vs. 108.86 ± 33.88 microg/L, p = 0.16). In diabetic subjects with CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and sex (beta = 0.21, p = 0.03) and glucose levels (beta = 0.25, p = 0.008). In diabetic subjects without CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and peripheral artery disease (beta = 0.16, p = 0.05) and glucose levels (beta = -0.09, p = 0.05).
  
  
  CONCLUSIONS
  Serum selenium levels did not differ between diabetic subjects with and without CAD. In diabetic subjects with CAD, the only determinants of serum selenium levels were sex and glucose levels. In diabetic subjects without CAD the only determinants of serum selenium levels were peripheral artery disease and glucose levels.
authors.affiliation: 3rd Department of Internal Medicine and Center of Diabetes, General Hospital of Nikaia "Ag, Panteleimon" - Piraeus, Greece. pathan@ath.forthnet.gr.
authors.forename: Alexios
authors.initials: A
authors.lastname: Sotiropoulos
authors.forename: Stavroula A
authors.initials: SA
authors.lastname: Papadodima
authors.forename: Athanasia K
authors.initials: AK
authors.lastname: Papazafiropoulou
authors.forename: Aggelos
authors.initials: A
authors.lastname: Ioannidis
authors.forename: Athanasia
authors.initials: A
authors.lastname: Kokkinari
authors.forename: Ourania
authors.initials: O
authors.lastname: Apostolou
authors.forename: Chara A
authors.initials: CA
authors.lastname: Spiliopoulou
authors.forename: Sotirios
authors.initials: S
authors.lastname: Athanaselis