title: New paradigms in the prevention of sudden cardiac arrest and heart failure treatment.
abstract: Congestive heart failure is a very real public health issue not only in the United States, but worldwide. Mortality in patients with congestive heart failure is typically either sudden cardiac death or pump failure. Paradoxically, patients with less severe heart failure are at higher relative risk of sudden cardiac death. Defining which patients are best treated with implantable defibrillators and resynchronization is the purpose of this review.
authors.affiliation: Division of Electrophysiology, Department of Cardiology, Tufts Medical Center, Boston, MA 02111, USA. MDohadwala@tuftsmedicalcenter.org
authors.forename: Mustafa
authors.initials: M
authors.lastname: Dohadwala
authors.forename: N A Mark
authors.initials: NA
authors.lastname: Estes
authors.forename: Mark S
authors.initials: MS
authors.lastname: Link
mesh_terms: D015415:Biomarkers / Q000097:blood; D058406:Cardiac Resynchronization Therapy; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D019317:Evidence-Based Medicine; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D009204:Myocardial Revascularization; D020097:Natriuretic Peptide, Brain / Q000097:blood; D009765:Obesity / Q000150:complications / Q000517:prevention & control; D010446:Peptide Fragments / Q000097:blood; D011237:Predictive Value of Tests; D011322:Primary Prevention; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012720:Severity of Illness Index; D013318:Stroke Volume
chemical_list: D015415:Biomarkers; D000451:Mineralocorticoid Receptor Antagonists; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain