title: The use of Helicobacter pylori stool antigen test for the diagnosis of Helicobacter pylori in Lagos, Nigeria.
abstract: OBJECTIVE
  This study was carried out to screen the use of Helicobacter pylori stool antigen (HpSA) tests for diagnosis and monitoring of H pylori in Nigeria.
  
  
  METHODS
  Seven hundred and forty participants were enrolled after informed consent was obtained, while 83 came back for a post-eradication test. The stool samples were taken from the patients at endoscopy and tested for HpSA.
  
  
  RESULTS
  The proportion of patients that were positive at the pretest, 520 (70.3%) was significantly higher (Fisher's exact p = 0.001) than those positive at the post-test, 44 (53%). There was a significant difference (F = 4.106, p = 0.043) between the mean age of those that came for the pretest (40.0 +/- 14.5 years) and those that came for the post-test, 43.6 +/- 11.6 years. More males than females had the tendency to come back for a post-eradication test.
  
  
  CONCLUSIONS
  Although potential bias was introduced during this study, HpSA using monoclonal antibody could still be used for diagnosis and monitoring of H pylori in Nigeria.
authors.affiliation: Molecular Biology and Biotechnology Division, Nigerian Institute of Medical Research, PMB 2013, Yaba, Logos, Nigeria. stellaismith@yahoo.com
authors.forename: S I
authors.initials: SI
authors.lastname: Smith
authors.forename: K S
authors.initials: KS
authors.lastname: Oyedeji
authors.forename: H A
authors.initials: HA
authors.lastname: Goodluck
authors.forename: M A
authors.initials: MA
authors.lastname: Fowora
authors.forename: E
authors.initials: E
authors.lastname: Anomneze
authors.forename: O A
authors.initials: OA
authors.lastname: Lesi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000276:immunology; D016009:Chi-Square Distribution; D002648:Child; D004724:Endoscopy; D005243:Feces / Q000382:microbiology*; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology
chemical_list: D000942:Antigens, Bacterial