title: Androgen deprivation therapy through bilateral orchiectomy: increased metabolic risks.
abstract: Prostate cancer is one of the most common malignancies in men. Previous research has determined that androgen deprivation therapy (ADT) may be accompanied by an unfavourable metabolic profile. In this prospective study, 133 men were recruited, including 46 prostate cancer patients who had undergone bilateral orchiectomy and been on flutamide (the ADT group), 37 men with prostate cancer who had undergone radical prostatectomy (the non-ADT group) and 50 normal control subjects (the control group). All subjects were followed for at least 12 months. From baseline to 3 months, men in the ADT group had increased levels of fasting serum insulin and low-density lipoprotein compared to the other two groups (P<0.05). No obvious changes were found in the other parameters (P>0.05). After 12 months, men in the ADT group had increased levels of waist circumference, fasting serum insulin and glucose, total cholesterol, high-density lipoprotein and low-density lipoprotein compared to the other two groups (P<0.05). Additionally, the morbidity rate of metabolic syndrome in the ADT group was higher (P<0.05) compared to the other two groups. ADT through surgical castration for men with prostate cancer may be associated with unfavourable metabolic changes. The benefits of the therapy should be balanced prudently against these risks.
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China.
authors.forename: Juan-Jie
authors.initials: JJ
authors.lastname: Bo
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Lian-Hua
authors.initials: LH
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Sha
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Lv
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Liu
authors.forename: Yi-Ran
authors.initials: YR
authors.lastname: Huang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005485:Flutamide / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009919:Orchiectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D000726:Androgen Antagonists; D005485:Flutamide