title: Comparison of diagnostic and prognostic capabilities of ¹⁸F-FDG-PET/CT, ¹³¹I-scintigraphy, and diffusion-weighted magnetic resonance imaging for postoperative thyroid cancer.
abstract: OBJECTIVE
  The first aim of this study was to compare the detectability of metastasis of postoperative differentiated thyroid cancer (DTC) among (131)I whole body scintigraphy (IWBS), fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT), and diffusion-weighted magnetic resonance imaging (DWI). The second aim was to clarify the association between the image pattern and prognosis.
  
  
  METHODS
  We evaluated 70 postoperative DTC patients on both a patient basis and an organ basis (lymph nodes, lung, bone), and we analyzed the correlation between the image pattern and the prognosis.
  
  
  RESULTS
  For the patient-basis analysis, the detectability by IWBS, PET/CT, and DWI was 67.1%, 84.2%, and 57.6%, respectively. IWBS provided complementary information to that provided by PET/CT in 11 of 70 (15.7%) cases. For the organ-basis analysis, IWBS was the best detector for lymph node metastasis (72.4%). PET/CT was superior to IWBS for detecting metastasis of bone (85.7% vs. 71.4%) and lung (94.1% vs. 62.7%). For the correlation analysis, PET and DWI positivity were the factors predicting a poor prognosis.
  
  
  CONCLUSIONS
  PET/CT was the best modality for detecting metastases in postoperative DTC patients, although IWBS provided complementary information. Because PET/CT and DWI gave similar information (e.g., positivity) suggesting poor prognoses, the combination of IWBS and DWI might be the method of choice for monitoring postoperative DTC.
authors.affiliation: Department of Radiology, School of Medicine, Miyazaki University, 5200 Kihara, Kiyotake-cho, Miyazaki 889-1692, Japan. snagama@med.miyazaki-u.ac.jp
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nagamachi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Wakamatsu
authors.forename: Shogo
authors.initials: S
authors.lastname: Kiyohara
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Nishii
authors.forename: Youichi
authors.initials: Y
authors.lastname: Mizutani
authors.forename: Seigo
authors.initials: S
authors.lastname: Fujita
authors.forename: Shigemi
authors.initials: S
authors.lastname: Futami
authors.forename: Hideo
authors.initials: H
authors.lastname: Arita
authors.forename: Masaomi
authors.initials: M
authors.lastname: Kuroki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakada
authors.forename: Noriko
authors.initials: N
authors.lastname: Uchino
authors.forename: Shozo
authors.initials: S
authors.lastname: Tamura
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kawai
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging / Q000556:secondary; D000231:Adenocarcinoma, Papillary / Q000000981:diagnostic imaging / Q000556:secondary; D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18