title: [Bioequivalence of anvifen and phenibut].
abstract: An open randomized crossover test on 18 healthy volunteers was used to study the pharmacokinetics of anvifen (acting substance, aminophenylbutyric acid) manufactured in capsules at the Joint-Stock Company "Antiviral" (Russia). The test was performed after single peroral administration in comparison with phenibut tablets of the same manufacturer. The concentration of unchanged aminophenylbutiric acid in the blood plasma was measured by HPLC with UV detection. It is established that anvifen and phenibut are bioequivalent in terms of pharmacokinetics.
authors.forename: A V
authors.initials: AV
authors.lastname: Zhezlova
authors.forename: V G
authors.initials: VG
authors.lastname: Belolipetskaia
authors.forename: S V
authors.initials: SV
authors.lastname: Blagodatskikh
authors.forename: E V
authors.initials: EV
authors.lastname: Merkulova
mesh_terms: D019540:Area Under Curve; D002214:Capsules / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics*; D008297:Male; D018697:Nootropic Agents / Q000493:pharmacokinetics*; D012015:Reference Standards; D012426:Russia; D012893:Sleep Wake Disorders / Q000188:drug therapy; D013607:Tablets / Q000493:pharmacokinetics*; D013810:Therapeutic Equivalency; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D002214:Capsules; D006993:Hypnotics and Sedatives; D018697:Nootropic Agents; D013607:Tablets; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid