title: Sensitivity and specificity of immunocytochemical staining of mycobacterial antigens in the cytoplasm of cerebrospinal fluid macrophages for diagnosing tuberculous meningitis.
abstract: The sensitivity and specificity of immunocytochemical staining of mycobacterial antigens in the cytoplasm of cerebrospinal fluid (CSF) macrophages for diagnosis of tuberculous meningitis (TBM) was prospectively compared with Ahuja criteria from 393 consecutive CSF specimens. The assay can play an important role for the diagnosis of TBM, with sensitivity of 73.5% and specificity of 90.7%.
authors.affiliation: Department of Neurology, Affiliated Sir Run Run Shaw Hospital, 3 East Qingchun Road, Hangzhou 310016, Zhejiang, China.
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Shao
authors.forename: Ping
authors.initials: P
authors.lastname: Xia
authors.forename: Tao
authors.initials: T
authors.lastname: Zhu
authors.forename: Jiong
authors.initials: J
authors.lastname: Zhou
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Jianjun
authors.initials: J
authors.lastname: Chen
authors.forename: Xingyue
authors.initials: X
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000032:analysis*; D002555:Cerebrospinal Fluid / Q000166:cytology* / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D019411:Clinical Laboratory Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007223:Infant; D008264:Macrophages / Q000737:chemistry / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium / Q000737:chemistry*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013194:Staining and Labeling / Q000379:methods; D014390:Tuberculosis, Meningeal / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D055815:Young Adult
chemical_list: D000942:Antigens, Bacterial