title: Preoperative vincristine for an inoperable choroid plexus papilloma: a case discussion and review of the literature.
abstract: The authors report the case of a 14-month-old boy with a large right intraventricular choroid plexus papilloma (CPP) for which the first attempt at resection resulted in life-threatening intraoperative hemorrhage. The tumor was unsuitable for embolization, and neoadjuvant ifosfamide, carboplatin, etoposide (ICE) chemotherapy had no effect on tumor size. However, chemotherapy with vincristine, although not impacting on CT perfusion parameters, resulted in a significant decrease in tumor size, enabling complete resection with manageable blood loss. The mechanism underlying the effect of vincristine in this case is uncertain, but it is a treatment strategy that warrants further evaluation for the treatment of CPPs that are not amenable to embolization.
authors.affiliation: School of Medicine, University of Manchester, United Kingdom.
authors.forename: Nii K
authors.initials: NK
authors.lastname: Addo
authors.forename: Ian D
authors.initials: ID
authors.lastname: Kamaly-Asl
authors.forename: Vivek A
authors.initials: VA
authors.lastname: Josan
authors.forename: Anna M
authors.initials: AM
authors.lastname: Kelsey
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Estlin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002831:Choroid Plexus / Q000098:blood supply / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D020288:Papilloma, Choroid Plexus / Q000188:drug therapy* / Q000601:surgery*; D011300:Preoperative Care; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine