title: [Effect of acetylsalicylic acid in complex with lipid nanostructures of various compositions on human platelet aggregation].
abstract: The effect of lipid nanocomplexes loaded with acetylsalicylic acid (aspirin) on platelet aggregation in vitro was investigated. The antithrombotic effect of aspirin in complex with liposomes prepared from pig brain glycosphingolipids is not only significantly higher compared to control, but also accompanied by leveling of the development of proaggregant effects. It was shown that ADP-induced platelet aggregation is reduced by the introduction of electrostatic charge in the structure of lipid bilayer of liposomes. The effect achieved for the liposomes possessing a negative charge was more pronounced in comparison to the effect of positively charged liposomes.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Suslina
authors.forename: D I
authors.initials: DI
authors.lastname: Prokhorov
authors.forename: A G
authors.initials: AG
authors.lastname: Shilova
authors.forename: A P
authors.initials: AP
authors.lastname: Kaplun
authors.forename: V G
authors.initials: VG
authors.lastname: Ionova
authors.forename: R D
authors.initials: RD
authors.lastname: Seĭfulla
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects*; D001923:Brain Chemistry; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D002855:Chromatography, Thin Layer; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D006028:Glycosphingolipids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008051:Lipid Bilayers / Q000097:blood / Q000737:chemistry; D008081:Liposomes / Q000097:blood* / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D055672:Static Electricity; D013552:Swine
chemical_list: D004337:Drug Carriers; D006028:Glycosphingolipids; D008051:Lipid Bilayers; D008081:Liposomes; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D001241:Aspirin