title: [Difficult therapeutic decision making in treatment of children with oesophageal atresia and trisomy of chromosome 18 - comments by geneticist, surgeon, neonatologist, paediatrician and anaesthesiologist].
abstract: Oesophageal atresia is a congenital defect of alimentary tract concerning the interruption of oesophagus with or without connection with the trachea. Its incidence is 1:3000-3500 of live-born. Associated anomalies including genetic disorders occur in 50% of patients. Edwards syndrome which is trisomy of chromosome 18 with poor prognosis. The incidence of Edwards syndrome is 1:5000 of live-born. About 5% of these children live more than 1 year. The aim of this article is a retrospective analysis of the course of treatment of newborn with oesophageal atresia and Edwards syndrome and making of therapeutic decision. The authors from different medical specializations: clinical genetics, paediatric surgery, paediatrics and neonatology, paediatric intensive care and palliative medicine, have undertaken a discussion regarding surgical treatment of children with oesophageal atresia and chromosomal, lethal syndrome.
authors.affiliation: Katedra Genetyki AM we Wroclawiu. smigiel@gen.am.wroc.pl
authors.forename: Robert
authors.initials: R
authors.lastname: Smigiel
authors.forename: Dariusz
authors.initials: D
authors.lastname: Patkowski
authors.forename: Beata
authors.initials: B
authors.lastname: Pyrek
authors.forename: Marzena
authors.initials: M
authors.lastname: Zielińska
authors.forename: Waldemar
authors.initials: W
authors.lastname: Gołebiowski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Czyzewska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szmyd
authors.forename: Maria M
authors.initials: MM
authors.lastname: Sasiadek
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D000776:Anesthesiology; D002887:Chromosomes, Human, Pair 18; D004933:Esophageal Atresia / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D004947:Esophagus / Q000002:abnormalities*; D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D009359:Neonatology; D011044:Poland; D011379:Prognosis; D012189:Retrospective Studies