title: Synthesis, spectroscopic characterization and comparative DNA binding studies of Schiff base complexes derived from L-leucine and glyoxal.
abstract: The mononuclear Schiff base complexes of the type, [ML(CH(3)OH)(2)] [M = Co(II), Ni(II), Cu(II) and Zn(II)] have been synthesized by template condensation of L-leucine and glyoxal. The complexes have been characterized on the basis of the results of the elemental analysis, molar conductance, magnetic susceptibility measurements and spectroscopic studies viz, FT-IR, Mass, (1)H NMR and (13)C NMR spectra. The UV-vis and magnetic moment data revealed an octahedral geometry around Co(II), Ni(II) ion with distortion around Cu(II) ion complex confirmed by EPR data. The conductivity data show a non-electrolytic nature of the complexes. Absorption and fluorescence spectroscopic studies support that all the complexes exhibit a significant binding to calf thymus DNA.
authors.affiliation: Division of Inorganic Chemistry, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. shakir078@yahoo.com
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shakir
authors.forename: Nida
authors.initials: N
authors.lastname: Shahid
authors.forename: Naushaba
authors.initials: N
authors.lastname: Sami
authors.forename: Mohammad
authors.initials: M
authors.lastname: Azam
authors.forename: Asad U
authors.initials: AU
authors.lastname: Khan
mesh_terms: D000818:Animals; D002417:Cattle; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004553:Electric Conductivity; D004563:Electrochemistry / Q000379:methods; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D006037:Glyoxal / Q000737:chemistry*; D007477:Ions; D007930:Leucine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009532:Nickel / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry*; D013053:Spectrophotometry / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
chemical_list: D007477:Ions; D012545:Schiff Bases; D003035:Cobalt; D006037:Glyoxal; D003300:Copper; D009532:Nickel; D004247:DNA; C427203:calf thymus DNA; D007930:Leucine