title: Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition.
abstract: BACKGROUND
  Insulin-like growth factor-1 (IGF-I) is important in normal brain development but in the adult brain, IGF-I overexpression may be a risk factor for tumor development.
  
  
  METHODS
  We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutrition. IGF-I and IGFBP-3 were measured by ELISAs.Conditional logistic regression was used to compute ORs and corresponding 95% CIs.
  
  
  RESULTS
  The risk of low-grade gliomas was elevated with increased IGF-I (OR = 3.60, 95% CI: 1.11-11.7; top vs. bottom quartile) and decreased with elevated IGFBP-3 concentrations (OR = 0.28, 95% CI: 0.09-0.84) after mutual adjustment of these two factors; these results became nonsignificant after exclusion of the first year of follow-up. No association was observed for high-grade gliomas or meningiomas. Both high IGF-I and IGFBP-3 concentrations were associated with risk of acoustic neuromas (IGF-I: OR = 6.63, 95% CI: 2.27-19.4, top vs. bottom tertile; IGFBP-3: OR = 7.07, 95% CI: 2.32-21.6), even after excluding the first year of follow-up.
  
  
  CONCLUSIONS
  High concentrations of IGF-I might be positively associated with risk of low-grade gliomas and acoustic neuromas, although we cannot exclude reverse causation, in particular for low-grade gliomas.
  
  
  CONCLUSIONS
  Factors of the IGF axis might be involved in the etiology of some types of brain tumors.
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. sabine.rohrmann@ifspm.uzh.ch
authors.forename: Sabine
authors.initials: S
authors.lastname: Rohrmann
authors.forename: Jakob
authors.initials: J
authors.lastname: Linseisen
authors.forename: Susen
authors.initials: S
authors.lastname: Becker
authors.forename: Naomi
authors.initials: N
authors.lastname: Allen
authors.forename: Brigitte
authors.initials: B
authors.lastname: Schlehofer
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Anja
authors.initials: A
authors.lastname: Olsen
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Beatrice S
authors.initials: BS
authors.lastname: Melin
authors.forename: Eiliv
authors.initials: E
authors.lastname: Lund
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Sara
authors.initials: S
authors.lastname: Grioni
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.forename: Catalina
authors.initials: C
authors.lastname: Bonet
authors.forename: Maria-Dolores
authors.initials: MD
authors.lastname: Chirlaque
authors.forename: María-José
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: Laudina
authors.initials: L
authors.lastname: Rodríguez
authors.forename: Miren
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authors.lastname: Dorronsoro
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: Pagona
authors.initials: P
authors.lastname: Lagiou
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: Laure
authors.initials: L
authors.lastname: Dossus
authors.forename: Verena A
authors.initials: VA
authors.lastname: Grote
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Krasimira
authors.initials: K
authors.lastname: Aleksandrova
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Fränzel J B
authors.initials: FJ
authors.lastname: van Duijnhoven
authors.forename: Petra H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Key
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Isabelle
authors.initials: I
authors.lastname: Romieux
authors.forename: Valentina
authors.initials: V
authors.lastname: Gallo
authors.forename: Dominique S
authors.initials: DS
authors.lastname: Michaud
authors.forename: Elio
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authors.lastname: Riboli
authors.forename: Rudolf
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authors.lastname: Kaaks
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008577:Meningeal Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D009752:Nutritional Status; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D014408:Biomarkers, Tumor; C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I