title: Aged worms erase epigenetic history.
abstract: Defining the molecular events that precipitate multisystem decline is an important component of aging research. In this issue, Jin et al. (2011) show that increased expression of the histone demethylase, utx-1, causes genome-wide decreases in histone H3K27 trimethylation, which includes the insulin/IGF-1 signaling (IIS) pathway that promotes aging.
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA. vlunyak@buckinstitute.org
authors.forename: Victoria V
authors.initials: VV
authors.lastname: Lunyak
authors.forename: Brian K
authors.initials: BK
authors.lastname: Kennedy