title: [Effect of the duration of time between chemo-radiotherapy and surgical intervention on the results of the combined treatment of rectal cancer].
abstract: Complex treatment included preoperative radiochemotherapy (fractionated TTD of 47 Gy), 5-FU 2.75-3.5 g, cisplatin 90 mg, surgery and postoperative adjuvant chemotherapy (XELOX). The radiochemotherapy/ surgery interval ranged 21-72 days (average--40; median--41.2 +/- 7.9). Patients were divided into two groups: those operated on within days 21-40 (1) and days 41-72 (2) to evaluate the impact of the interval between surgery and completion of radiochemotherapy. The intervals longer than 40 days were not followed by longer sphincter-saving operations, higher intraoperative blood loss or postoperative complication incidence, as compared with the 21-40 day interval. Besides, radiochemotherapy-related alterations in tumor tissues arising more than 40 days after exposure were more pronounced, yet unaccompanied by significantly better end results.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Shelygin
authors.forename: A O
authors.initials: AO
authors.lastname: Rasulov
authors.forename: A V
authors.initials: AV
authors.lastname: Boĭko
authors.forename: I V
authors.initials: IV
authors.lastname: Droshneva
mesh_terms: D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D019583:Dose Fractionation, Radiation; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D005472:Fluorouracil