title: Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma.
abstract: The objective of this study was to evaluate the prognostic impact of genomic regions in a series of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphomas (HIV-DLBCLs) and post-transplant DLBCLs (PT-DLBCLs) analyzed by genome-wide DNA profiling. Minimal common regions (MCRs) were estimated on genomic profiles obtained using Affymetrix Human Mapping 250k Nsp I arrays and tested for their impact on clinical outcome by univariate analysis on 36 PT-DLBCLs, 19 HIV-DLBCLs and, as a control group, 149 DLBCLs arising in immunocompetent individuals (IC-DLBCLs). PT-DLBCL and HIV-DLBCL presented a similar outcome. Immunodeficiency-related DLBCL (ID-DLBCL) had a worse overall survival (OS) than IC-DLBCL. Seven MCRs showed a statistical impact on OS in PT-DLBCL and four in HIV-DLBCL. Among these, the presence of gains at 1q or at 18q defined a group of patients with PT-DLBCL with a very poor outcome (p < 0.0001). The presence of del(3p14.2) or of + 2p23.1 identified a group of HIV-DLBCLs with a very poor outcome (p = 0.0072). It was concluded that genomic aberrations affecting outcome differ between ID-DLBCL and IC-DLBCL and are also dependent on the type of acquired immunodeficiency.
authors.affiliation: Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland.
authors.forename: Ivo
authors.initials: I
authors.lastname: Kwee
authors.forename: Daniela
authors.initials: D
authors.lastname: Capello
authors.forename: Andrea
authors.initials: A
authors.lastname: Rinaldi
authors.forename: Paola M V
authors.initials: PM
authors.lastname: Rancoita
authors.forename: Govind
authors.initials: G
authors.lastname: Bhagat
authors.forename: Tim C
authors.initials: TC
authors.lastname: Greiner
authors.forename: Michele
authors.initials: M
authors.lastname: Spina
authors.forename: Annunziata
authors.initials: A
authors.lastname: Gloghini
authors.forename: Wing C
authors.initials: WC
authors.lastname: Chan
authors.forename: Marco
authors.initials: M
authors.lastname: Paulli
authors.forename: Emanuele
authors.initials: E
authors.lastname: Zucca
authors.forename: Umberto
authors.initials: U
authors.lastname: Tirelli
authors.forename: Antonino
authors.initials: A
authors.lastname: Carbone
authors.forename: Gianluca
authors.initials: G
authors.lastname: Gaidano
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertoni
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000628:therapy; D002869:Chromosome Aberrations; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000628:therapy; D020869:Gene Expression Profiling / Q000379:methods; D023281:Genomics / Q000379:methods*; D006801:Humans; D053208:Kaplan-Meier Estimate; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000235:genetics* / Q000628:therapy; D017063:Outcome Assessment, Health Care; D011379:Prognosis