title: Ovarian clear cell carcinoma as a stress-responsive cancer: influence of the microenvironment on the carcinogenesis and cancer phenotype.
abstract: Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by inducing unique gene expressions, which potentially serves as a molecular marker for treatment modality. In this review, by referring to other articles in this field, we explore how the carcinogenic microenvironment affects the phenotype and gene expression of a cancer, and how we can develop new treatment based on this concept.
authors.affiliation: Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. mandai@kuhp.kyoto-u.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Mandai
authors.forename: Noriomi
authors.initials: N
authors.lastname: Matsumura
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Baba
authors.forename: Ken
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Junzo
authors.initials: J
authors.lastname: Hamanishi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Konishi
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D018269:Carcinoma, Endometrioid / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D004715:Endometriosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D018384:Oxidative Stress / Q000502:physiology; D059016:Tumor Microenvironment