title: Coagulation and prothrombotic state parameters: a clinical analysis during early pregnancy.
abstract: OBJECTIVE
  The aim of this study is to assess the changes in coagulation, thrombosis, anticoagulation, and fibrinolysis during early pregnancy.
  
  
  METHODS
  One hundred and five pregnant women with monozygotic pregnancies between 10 and 12 weeks gestation were randomly enrolled as the study group, and another 82 non-pregnant women were selected as the control group. Coagulation parameters and prothrombotic state parameters were measured.
  
  
  RESULTS
  Fg, F1 + 2, thrombin-antithrombin complex, GMP140, D-dimer, and plasminogen activator inhibitor 2 were statistically different between the study and the control groups (p < 0.008). The coagulation, fibrinolytic, and the antifibrinolytic functions of healthy pregnant women are enhanced during early pregnancy, whereas the anticoagulation is slightly increased.
  
  
  CONCLUSIONS
  Coagulation, fibrinolysis, and antifibrinolysis remain at high levels, whereas the platelet activation remains at low levels during early pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Yanjiang Road 107, Guangdong, Guangzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.forename: L
authors.initials: L
authors.lastname: Meng
authors.forename: M
authors.initials: M
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Tan
authors.forename: L
authors.initials: L
authors.lastname: Gao
authors.forename: J
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000990:Antithrombin III; D001777:Blood Coagulation; D016022:Case-Control Studies; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D010447:Peptide Hydrolases / Q000097:blood; D017396:Plasminogen Activator Inhibitor 2 / Q000097:blood; D015539:Platelet Activation; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D055815:Young Adult
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D017396:Plasminogen Activator Inhibitor 2; C046193:antithrombin III-protease complex; C036309:fibrin fragment D; D000990:Antithrombin III; D010447:Peptide Hydrolases