title: Immunoglobulin G4-related sclerosing disease: experience with this novel entity in a local hospital.
abstract: OBJECTIVE
  To review the site of involvement, clinical presentation, and treatment outcome of patients having immunoglobulin G4-related sclerosing disease in a local regional hospital.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Pamela Youde Nethersole Eastern Hospital, Hong Kong.
  
  
  METHODS
  All patients with a diagnosis of immunoglobulin G4-related sclerosing disease in the hospital diagnosed in the period from April 2008 to March 2010.
  
  
  RESULTS
  A total of 12 patients with involvement of various organs were identified. There was a male predominance (male-to-female ratio=5:1). The mean age at diagnosis was 65 years. The salivary glands, biliary tract, pancreas, and cervical lymph nodes were the commonest involved sites. The immunoglobulin G4 level was elevated in 83% of the patients. Patients usually appeared to respond well to steroid treatment.
  
  
  CONCLUSIONS
  Immunoglobulin G4-related sclerosing disease is a systemic disease and can involve various systems.
authors.affiliation: Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
authors.forename: T L
authors.initials: TL
authors.lastname: Ng
authors.forename: I S
authors.initials: IS
authors.lastname: Leong
authors.forename: W L
authors.initials: WL
authors.lastname: Tang
authors.forename: K F
authors.initials: KF
authors.lastname: Chan
authors.forename: Y W
authors.initials: YW
authors.lastname: Luk
authors.forename: W C
authors.initials: WC
authors.lastname: Lao
authors.forename: C M
authors.initials: CM
authors.lastname: Leung
authors.forename: S Y
authors.initials: SY
authors.lastname: Liu
authors.forename: C S
authors.initials: CS
authors.lastname: Kho
authors.forename: K L
authors.initials: KL
authors.lastname: Lee
authors.forename: K K
authors.initials: KK
authors.lastname: Chan
authors.forename: M K W
authors.initials: MK
authors.lastname: Li
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D012189:Retrospective Studies; D012598:Sclerosis / Q000188:drug therapy / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G