title: Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma.
abstract: To explore the expression of matrix metalloproteinase 9 (MMP-9), type IV collagen (Col IV) and vascular endothelial growth factor (VEGF) in adamantinomatous craniopharyngioma (ACP) and analyze the correlation between the level of these markers and adamantimous craniopharyngiomas recurrence. Expressions of MMP-9, Col IV and VEGF were tested by immunohistochemistry (IHC) in 40 cases of ACP, including 24 cases of primary group and 16 cases of recurred group. The expression level of MMP-9 and VEGF in recurred group were significantly higher than primary group (93.7% vs. 41.7%, P < 0.05, 87.5% vs. 45.8%, P < 0.05, respectively). The expression of Col IV in the recurred group was significant different from the primary group (Z = -2.619, P < 0.05). MMP-9, Col IV and VEGF may be the potential specific bio-marker related to the recurrence of ACP.
authors.affiliation: Department of Neurosurgery, Yulin Number 2 Hospital, Yulin, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Xia
authors.forename: Wenqing
authors.initials: W
authors.lastname: Liu
authors.forename: Shengdong
authors.initials: S
authors.lastname: Li
authors.forename: Ge
authors.initials: G
authors.lastname: Jia
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chunde
authors.initials: C
authors.lastname: Li
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Ma
authors.forename: Jihui
authors.initials: J
authors.lastname: Tian
authors.forename: Jian
authors.initials: J
authors.lastname: Gong
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D024141:Collagen Type IV / Q000096:biosynthesis*; D003397:Craniopharyngioma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
chemical_list: D024141:Collagen Type IV; D042461:Vascular Endothelial Growth Factor A; D020780:Matrix Metalloproteinase 9