title: Semiparametric transformation models for joint analysis of multivariate recurrent and terminal events.
abstract: Recurrent event data occur in many clinical and observational studies, and in these situations, there may exist a terminal event such as death that is related to the recurrent event of interest. In addition, sometimes more than one type of recurrent events may occur, that is, one may encounter multivariate recurrent event data with some dependent terminal event. For the analysis of such data, one must take into account the dependence among different types of recurrent events and that between the recurrent events and the terminal event. In this paper, we extend a method for univariate recurrent and terminal events and propose a joint modeling approach for regression analysis of the data and establish the finite and asymptotic properties of the resulting estimates of unknown parameters. The method is applied to a set of bivariate recurrent event data arising from a long-term follow-up study of childhood cancer survivors.
authors.affiliation: Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105, U.S.A.. liang.zhu@stjude.org
authors.forename: Liang
authors.initials: L
authors.lastname: Zhu
authors.forename: Jianguo
authors.initials: J
authors.lastname: Sun
authors.forename: Deo Kumar
authors.initials: DK
authors.lastname: Srivastava
authors.forename: Xingwei
authors.initials: X
authors.lastname: Tong
authors.forename: Wendy
authors.initials: W
authors.lastname: Leisenring
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Robison
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003198:Computer Simulation / Q000706:statistics & numerical data; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data; D015999:Multivariate Analysis; D009369:Neoplasms / Q000401:mortality; D012008:Recurrence; D016019:Survival Analysis; D055815:Young Adult