title: [Effect of migrepin on activity of trigeminal nucleus caudalis neurons].
abstract: Neurophysiological experiments on anesthetized rats were used to study the effects of various doses (12.5, 25, 37.5 mg/kg, i.v.) of drug composition migrepin (representing a combination of potassium-2,4-dichlorobenzoate, carbamazepine, and caffeine) on background firing of the trigeminal nucleus caudalis neurons and their responses to electrical stimulation of the dura mater. It was found that migrepin produces direct, dose-dependent inhibitory action on functional activity of TNC neurons. The results confirmed anti-migraine properties of the drug but did not exclude the necessity to study its action in clinical trials.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Sokolov
authors.forename: O A
authors.initials: OA
authors.lastname: Liubashina
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Ignatov
authors.forename: S S
authors.initials: SS
authors.lastname: Panteleev
authors.forename: A O
authors.initials: AO
authors.lastname: Syrovaia
authors.forename: T V
authors.initials: TV
authors.lastname: Zviagintseva
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002220:Carbamazepine / Q000494:pharmacology; D002723:Chlorobenzoates / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004388:Dura Mater / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D007275:Injections, Intravenous; D008297:Male; D008839:Microelectrodes; D008881:Migraine Disorders / Q000188:drug therapy* / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects*; D009991:Oscillometry; D011188:Potassium / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014275:Trigeminal Caudal Nucleus / Q000187:drug effects* / Q000502:physiology
chemical_list: D000700:Analgesics; D002723:Chlorobenzoates; D004338:Drug Combinations; C070735:2,4-dichlorobenzoic acid; D002220:Carbamazepine; D002110:Caffeine; D011188:Potassium