title: Protective effects of radon inhalation on carrageenan-induced inflammatory paw edema in mice.
abstract: We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m(3) of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.
authors.affiliation: Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kataoka
authors.forename: Junichi
authors.initials: J
authors.lastname: Teraoka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sakoda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamato
authors.forename: Mayuko
authors.initials: M
authors.lastname: Monden
authors.forename: Yuu
authors.initials: Y
authors.lastname: Ishimori
authors.forename: Takaharu
authors.initials: T
authors.lastname: Nomura
authors.forename: Takehito
authors.initials: T
authors.lastname: Taguchi
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Yamaoka
mesh_terms: D000818:Animals; D002351:Carrageenan; D002374:Catalase / Q000378:metabolism; D004487:Edema / Q000628:therapy*; D005260:Female; D007249:Inflammation / Q000628:therapy*; D008054:Lipid Peroxides / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000097:blood; D011886:Radon / Q000008:administration & dosage*; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D008054:Lipid Peroxides; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D002351:Carrageenan; D002374:Catalase; D013482:Superoxide Dismutase; D011886:Radon