title: Iridoids from the roots of Valeriana jatamansi and their neuroprotective effects.
abstract: Three new iridoids, valeriandoids A-C (1-3), together with three known analogues (4-6), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. All the isolated compounds were evaluated for their neuroprotective effects and compounds 1, 3, 4 and 6 showed moderate neuroprotective effects.
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Xie
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Ma
authors.forename: Wenbin
authors.initials: W
authors.lastname: Hou
authors.forename: Tiejun
authors.initials: T
authors.lastname: Zhang
mesh_terms: D002460:Cell Line; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D009447:Neuroblastoma; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014632:Valerian / Q000737:chemistry*
chemical_list: D039823:Iridoids; D018696:Neuroprotective Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; C495640:valeriananoid A; C495641:valeriananoid B; C495642:valeriananoid C