title: Mesotherapy, definition, rationale and clinical role: a consensus report from the Italian Society of Mesotherapy.
abstract: OBJECTIVE
  Since its introduction in the 1950s, the use of mesotherapy has generated much interest among clinicians and patients. The Italian Society of Mesotherapy (SIM) brought together a panel of experts to review available evidence and to draw up a series of recommendations on the use of intradermal therapy (LIT) in clinical practice.
  There was overwhelming agreement among Consensus Group members that, when used correctly, LIT is a valuable therapeutic option in the treatment of painful, loco-regional conditions. They also emphasised that the clinical efficacy of LIT has been demonstrated in the management of chronic venous lymphatic insufficiency, oedematous fibrosclerotic panniculopathy and facial skin aging. The experts were unanimous on the use of LIT in vaccination. Mesotherapy is not a substitute for other therapeutic options and should only be used when the patient has been fully informed of its advantages and limitations. Likewise the procedure should only be carried out by an experienced qualified physician.
  
  
  CONCLUSIONS
  Although there was widespread agreement among the Consensus Group on the place of LIT in several indications, the Authors reiterated the need for more large-scale clinical trials to determine the specific benefits and limitations in some areas of the application of intradermal therapy.
authors.affiliation: Emergency Care, Critical Care Medicine, Pain Medicine and Anesthesiology Department, Tor Vergata Polyclinic, University of Tor Vergata, Rome, Italy. massimo.mammucari@libero.it
authors.forename: M
authors.initials: M
authors.lastname: Mammucari
authors.forename: A
authors.initials: A
authors.lastname: Gatti
authors.forename: S
authors.initials: S
authors.lastname: Maggiori
authors.forename: C A
authors.initials: CA
authors.lastname: Bartoletti
authors.forename: A F
authors.initials: AF
authors.lastname: Sabato
mesh_terms: D006801:Humans; D007271:Injections, Intradermal / Q000379:methods*; D007558:Italy; D057748:Mesotherapy / Q000379:methods*; D012952:Societies; D014612:Vaccines / Q000008:administration & dosage
chemical_list: D014612:Vaccines