title: Bioactivities of Piper aduncum L. and Piper obliquum Ruiz & Pavon (Piperaceae) essential oils from Eastern Ecuador.
abstract: Essential oils from aerial parts of Piper aduncum (Matico) and Piper obliquum (Anis del Oriente) of ecuadorian origin were analyzed by GC-FID, GC-MS, (13)C NMR and their biological and pharmacological activities were assessed. Chemical composition proved to be unusually different from previous reports for safrole-rich P. obliquum (45.8%), while P. aduncum main constituent was dillapiol (45.9%). No genotoxic activity was found in the Ames/Salmonella typhimurium (TA98 and TA100) assay, either with or without S9 activation. Mutagen-protective properties, evaluated using sodium azide, 2-nitrofluorene and 2-aminoanthracene as mutagens/promutagens, was observed against promutagen 2-aminoanthracene, likely in consequence of microsomial deactivation. Antimicrobial assays have been performed on Gram+/Gram- bacteria, dermatophyte and phytopathogenic fungi and best results were provided by P. aduncum against fungal strains with complete inhibition at 500μg/ml. Preliminary analgesic and antithrombotic activities evidenced the absence of the former in hot plate and edema assays and a limited antiplatelet action against three different agonists (ADP, AA and U46619). Both oils have a very limited antioxidant capacity.
authors.affiliation: Dip. di Biologia ed Evoluzione, Sez. Risorse Agrotecnologiche e Farmaceutiche AgriUnife, Università degli Studi di Ferrara, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Guerrini
authors.forename: Gianni
authors.initials: G
authors.lastname: Sacchetti
authors.forename: Damiano
authors.initials: D
authors.lastname: Rossi
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Paganetto
authors.forename: Mariavittoria
authors.initials: M
authors.lastname: Muzzoli
authors.forename: Elisa
authors.initials: E
authors.lastname: Andreotti
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Tognolini
authors.forename: Maria E
authors.initials: ME
authors.lastname: Maldonado
authors.forename: Renato
authors.initials: R
authors.lastname: Bruni