title: Reversal of quetiapine-induced altered mental status with physostigmine: a case series.
abstract: Quetiapine overdose is a clinical entity commonly encountered in emergency departments. Quetiapine is a drug with many mechanisms, including antimuscarinic effects. Traditionally, treatment of quetiapine toxicity has been primarily supportive care. Case reports exist documenting improvement in mental status in these patients after administration of physostigmine, a carbamate capable of reversing antimuscarinic toxicity. In this descriptive case series, 3 patients with quetiapine toxicity treated with physostigmine are reported. In each case, the patient had significant altered mental status that was rapidly reversed with administration of physostigmine. In all 3 cases, patient disposition was changed to a lower level of care, requiring less invasive monitoring. In 1 case, intubation was prevented. Because quetiapine toxicity is commonly encountered and the use of physostigmine in this setting is a potentially practice-altering treatment, emergency physicians should be aware of this phenomenon.
authors.affiliation: Hennepin Regional Poison Center, Mail Code: RL, Minneapolis, MN 55415, USA. jonbcole@gmail.com
authors.forename: Jon B
authors.initials: JB
authors.lastname: Cole
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Stellpflug
authors.forename: Heather
authors.initials: H
authors.lastname: Ellsworth
authors.forename: Carson R
authors.initials: CR
authors.lastname: Harris
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D003244:Consciousness Disorders / Q000139:chemically induced* / Q000188:drug therapy; D003987:Dibenzothiazepines / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D062787:Drug Overdose / Q000188:drug therapy; D004636:Emergency Service, Hospital; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D010830:Physostigmine / Q000627:therapeutic use*; D000069348:Quetiapine Fumarate; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D002800:Cholinesterase Inhibitors; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D010830:Physostigmine