title: Structural and biophysical insight into cholesteryl ester-transfer protein.
abstract: CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data.
authors.affiliation: Pfizer Research and Development, Eastern Point Road, Groton, CT 06430, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Hall
authors.forename: Xiayang
authors.initials: X
authors.lastname: Qiu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001665:Binding Sites; D002318:Cardiovascular Diseases / Q000188:drug therapy; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism; D017124:Conserved Sequence; D019143:Evolution, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D010743:Phospholipids / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D000924:Anticholesteremic Agents; D053480:Cholesterol Ester Transfer Proteins; D002788:Cholesterol Esters; D010743:Phospholipids