title: Association of PPAR polymorphisms with cytokine levels in allergic rhinitis.
abstract: Our aim was to study the association of Pro12Ala and exon6 C161T polymorphisms of PPARgamma and intron7 G/C polymorphisms of PPAR-alpha with clinical symptoms, peak nasal inspiratory flow values, serum soluble TNF-alpha, TNF-R1, Fas, Fas ligand and IgE concentrations in patients with seasonal allergic rhinitis during and after pollen season. We performed a follow-up study of 66 Hungarian patients with seasonal allergic rhinitis and 180 healthy referent subjects. We used PCR-RFLP technique and ELISA. The distribution of mutant alleles of PPAR-gamma and -alpha did not differ in patients and referent subjects. Patients carrying the mutant 12Ala, exon6 161T alleles of PPAR-gamma and intron7 C allele of PPAR-alpha had significantly higher clinical symptom score values, TNF-alpha and IgE levels and lower peak nasal inspiratory flow values during and after pollen season. The results indicated that nuclear receptors PPAR-gamma and PPAR-alpha are involved in the regulation of inflammatory mediator production in patients with seasonal allergic rhinitis and polymorphisms of the receptors are very likely to contribute to the heterogeneity of clinical and immunological parameters of allergic patients.
authors.affiliation: Department of Oto-Rhino-Laryngology, Head- and Neck Surgery, Semmelweis University, Szigony u. 36, Budapest, 1083, Hungary. krasznai.magda@gmail.com
authors.forename: Magdolna
authors.initials: M
authors.lastname: Krasznai
authors.forename: Kinga
authors.initials: K
authors.lastname: Szaniszlo
authors.forename: Helga
authors.initials: H
authors.lastname: Kraxner
authors.forename: Eszter
authors.initials: E
authors.lastname: Vargha
authors.forename: Margit
authors.initials: M
authors.lastname: Kovacs
authors.forename: Edit
authors.initials: E
authors.lastname: Kaszas
authors.forename: Gyorgyi
authors.initials: G
authors.lastname: Mezei
authors.forename: Endre
authors.initials: E
authors.lastname: Cserhati
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Borocz
authors.forename: Karoly
authors.initials: K
authors.lastname: Cseh
mesh_terms: D000328:Adult; D000483:Alleles; D016207:Cytokines / Q000097:blood*; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D047493:PPAR alpha / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D006255:Rhinitis, Allergic, Seasonal / Q000235:genetics*
chemical_list: D016207:Cytokines; D047493:PPAR alpha; D047495:PPAR gamma