title: Biomimetic organocatalytic asymmetric synthesis of 2-substituted piperidine-type alkaloids and their analogues.
abstract: Natural substances such as pelletierine and its analogues have been prepared in up to 97% ee and good yield by a protective-group-free, biomimetic approach. Usage of benzonitrile or acetonitrile as solvents effectively prevents product racemization.
authors.affiliation: Dipartimento di Chimica, Sapienza University of Roma and Istituto di Chimica Biomolecolare del CNR, P.le Aldo Moro 5, 00185 Roma, Italy.
authors.forename: Mattia R
authors.initials: MR
authors.lastname: Monaco
authors.forename: Polyssena
authors.initials: P
authors.lastname: Renzi
authors.forename: Daniele M
authors.initials: DM
authors.lastname: Scarpino Schietroma
authors.forename: Marco
authors.initials: M
authors.lastname: Bella
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D032701:Biomimetics; D002384:Catalysis; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D010880:Piperidines; D011392:Proline