title: Can neurodegeneration be separated from neuropathological hallmarks of chronic idiopathic human neurodegenerative disease? A perspective from modelling!
abstract: Chronic neurodegenerative disease is characterized by extensive regional loss of neurons in the brain and neuropathological hallmarks in surviving neurones. Genetic modelling by overexpression of hallmark proteins does not produce extensive neurodegeneration, whereas genetic deletion of neuronal 26S proteasomes does, as well as some hallmarks of human disease.
authors.affiliation: School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Paine
authors.forename: James
authors.initials: J
authors.lastname: Lowe
authors.forename: Lynn
authors.initials: L
authors.lastname: Bedford
authors.forename: R John
authors.initials: RJ
authors.lastname: Mayer
mesh_terms: D000818:Animals; D016923:Cell Death; D002908:Chronic Disease; D004195:Disease Models, Animal; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D058225:Plaque, Amyloid / Q000378:metabolism