title: [Clinical and laboratory investigation of patients with hematologic malignancies harboring der(1;7)(q10;p10)].
abstract: OBJECTIVE
  To investigate the clinical and laboratory characteristics of patients with various hematological malignancies harboring der(1;7)(q10;p10).
  
  
  METHODS
  Bone marrow samples were collected and undergone short-time unstimulated culture and R-banding, and karyotyped by conventional cytogenetic assay (CCA). Megalokaryocytes were detected by streptavidin-AKP (SAP). Retrospective analyses including the clinical and laboratory data were performed.
  
  
  RESULTS
  Nineteen of the 21 patients were male. Most of the patients are of older age. Thirteen cases (61.9%) were der(1;7)(q10;p10) without additional aberrations, 8(38.1%) patients had additional aberrations. Sixteen out of the 18 cases (88.9%) who underwent SAP analysis had diminutive megalokaryocyte, and lymphoid megalokaryocyte was found in 10 cases (55.6%). The der(1;7) patients manifested poor response to treatment.
  
  
  CONCLUSIONS
  The der(1;7) patients demonstrated distinct male predominance, older age at diagnosis, and some clinically distinctive features. These patients showed poor prognosis. The cytogenetic abnormality, i.e., der(1;7)(q10;p10), can be used as a prognostic indicator.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P. R. China.
authors.forename: Fang-yun
authors.initials: FY
authors.lastname: Xu
authors.forename: Xu-ping
authors.initials: XP
authors.lastname: Liu
authors.forename: Cheng-wen
authors.initials: CW
authors.lastname: Li
authors.forename: Shuang
authors.initials: S
authors.lastname: Qin
authors.forename: Wan-chen
authors.initials: WC
authors.lastname: Sun
authors.forename: Wen
authors.initials: W
authors.lastname: Cui
authors.forename: Ying-chang
authors.initials: YC
authors.lastname: Mi
authors.forename: Ren-chi
authors.initials: RC
authors.lastname: Yang
authors.forename: Jian-xiang
authors.initials: JX
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D005260:Female; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000628:therapy; D006801:Humans; D007753:Laboratories; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014178:Translocation, Genetic / Q000235:genetics*; D016896:Treatment Outcome; D055815:Young Adult