title: Safety and efficacy of exercise training after coronary stenting in patients with stable coronary artery disease.
abstract: BACKGROUND
  Exercise training (ET) after coronary stenting is considered to have a risk of stent thrombosis (ST). The present study investigated whether ET increases the incidence of ST in patients undergoing coronary stenting.
  
  
  RESULTS
  The current study was a prospective observational study. We enrolled 3,672 patients who underwent successful coronary stenting. Patients decided whether to participate in exercise and were divided into an ET group (n=1,592) and a control group (n=2,080). The primary endpoint was the incidence of ST. Secondary endpoints were major adverse cardiovascular events (MACE: death, myocardial infarction, and stroke) and unscheduled hospital visits for angina. The incidence of ST and MACE were similar in both groups (1.8% vs. 2.0%, P=0.73, 14.9% vs. 15.0%, P=0.97, respectively). Unscheduled hospital visits were significantly lower in the ET group (20.2% vs. 27.2%, P<0.0001). After adjusting for baselines, the ET group had no significant increase in ST (hazard ratio (HR) 0.86, adjusted P=0.56) and MACE (HR 0.98, adjusted P=0.83). The ET was effective to prevent an unscheduled hospital visits for worsening angina (HR 0.67, adjusted P<0.0001).
  
  
  CONCLUSIONS
  Moderate ET after successful coronary stenting does not increase the incidence of ST and MACE, and was effective in reducing unscheduled hospital visits for angina.
authors.affiliation: Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan. sogacchy@yahoo.co.jp
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Soga
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Yokoi
authors.forename: Kisaki
authors.initials: K
authors.lastname: Amemiya
authors.forename: Masashi
authors.initials: M
authors.lastname: Iwabuchi
authors.forename: Masakiyo
authors.initials: M
authors.lastname: Nobuyoshi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris; D003324:Coronary Artery Disease / Q000150:complications / Q000628:therapy*; D003643:Death; D005081:Exercise Therapy / Q000009:adverse effects*; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction; D019370:Observation; D011446:Prospective Studies; D015607:Stents / Q000009:adverse effects*; D020521:Stroke; D013927:Thrombosis / Q000209:etiology; D016896:Treatment Outcome; D055815:Young Adult