title: Late occurrence of drop metastasis to the spine in a case of esthesioneuroblastoma.
abstract: Esthesioneuroblastoma is an aggressive neuroectodermal tumor that originates from the olfactory mucosa and often recurs locally. Distant metastasis of esthesioneuroblastoma has been described, but there are few reports of drop metastasis to the spinal cord. Here, we report a case of multiple drop metastases to the cervical, thoracic, and lumbar regions of the spinal cord that occurred 18 years after resection and radiotherapy of the original anterior cranial fossa lesion. There was no evidence of local recurrence. The symptomatic lesion was treated with resection and adjuvant chemotherapy. The options available for treatment of this disease are summarized with a review of the few reported cases of spinal metastasis of esthesioneuroblastoma.
authors.affiliation: Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon 97239, USA.
authors.forename: Abigail J
authors.initials: AJ
authors.lastname: Rao
authors.forename: S Humayun
authors.initials: SH
authors.lastname: Gultekin
authors.forename: Edward A
authors.initials: EA
authors.lastname: Neuwelt
authors.forename: Hector R
authors.initials: HR
authors.lastname: Cintrón-Colón
authors.forename: Brian T
authors.initials: BT
authors.lastname: Ragel
mesh_terms: D035262:Cranial Fossa, Anterior / Q000473:pathology*; D018304:Esthesioneuroblastoma, Olfactory / Q000556:secondary*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019292:Skull Base Neoplasms / Q000473:pathology*; D013125:Spinal Neoplasms / Q000556:secondary*