title: Chiral sulfinamide/achiral sulfonic acid cocatalyzed enantioselective protonation of enol silanes.
abstract: The application of chiral sulfinamides and achiral sulfonic acids as a cocatalyst system for enantioselective protonation reactions is described. Structurally simple, easily accessible sulfinamides were found to induce moderate-to-high ee's in the formation of 2-aryl-substituted cycloalkanones from the corresponding trimethylsilyl enol ethers.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Beck
authors.forename: Alan M
authors.initials: AM
authors.lastname: Hyde
authors.forename: Eric N
authors.initials: EN
authors.lastname: Jacobsen
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D011522:Protons; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000737:chemistry*
chemical_list: D000577:Amides; D011522:Protons; D012821:Silanes; D013451:Sulfonic Acids