title: Fludrocortisone improves nausea in children with orthostatic intolerance (OI).
abstract: INTRODUCTION/RESULTS:                          In 17 patients, chronic idiopathic nausea was associated with orthostatic intolerance (OI) by abnormal tilt table tests (88%) or gastric dysrhythmias (71%). After fludrocortisone treatment, there was >26% nausea improvement in 71%, 1-25% in 6%, and no improvement in 24%. In six subjects, EGGs repeated after >50% nausea improvement all remained to be abnormal, suggesting nausea is independent of gastric dysrhythmias.
  
  
  CONCLUSIONS
  Association of EGG abnormalities and OI in this subset of nausea patients suggests a generalized disturbance of autonomic regulation.
authors.affiliation: Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Wake Forest University School of Medicine, Winston-Salem, NC, USA. jfortuna@wfubmc.edu
authors.forename: John E
authors.initials: JE
authors.lastname: Fortunato
authors.forename: Hossam A
authors.initials: HA
authors.lastname: Shaltout
authors.forename: Megan M
authors.initials: MM
authors.lastname: Larkin
authors.forename: Peter C
authors.initials: PC
authors.lastname: Rowe
authors.forename: Debra I
authors.initials: DI
authors.lastname: Diz
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Koch
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005438:Fludrocortisone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009325:Nausea / Q000150:complications / Q000188:drug therapy*; D054971:Orthostatic Intolerance / Q000150:complications*; D012189:Retrospective Studies
chemical_list: D000893:Anti-Inflammatory Agents; D005438:Fludrocortisone