title: [Toll-like receptor 2 R753Q polymorphisms are associated with an increased risk of infective endocarditis].
abstract: The ability to respond to the ligands of toll-like receptors (TLR) could be affected by single nucleotide polymorphisms in TLR codifying genes. The influence of the polymorphisms TLR2 (R753Q, R677W), TLR4 (D299G, T399I) and CD14 (C-159T) was consecutively studied in 65 patients with infective endocarditis. The control group (n=66) consisted of healthy volunteers. All the polymorphisms were genotyped by means of restriction analysis after their amplification. An association between endocarditis and variants of TLR2 R753Q (P <.001) was observed, but no association with other polymorphisms was found. The TLR2 R753Q co-dominant (odds ratio=13.33), recessive (odds ratio=9.12) and dominant (odds ratio=3.65) genotypes showed a positive association with the infective endocarditis phenotype. The polymorphism TLR2 R753Q was associated with a greater susceptibility towards the development of infective endocarditis. Further studies are required to validate these results and identify other genetic risk factors.
authors.affiliation: Servicio de Cirugía Cardiaca, Instituto de Ciencias del Corazón (ICICOR), Hospital Clínico Universitario de Valladolid, Valladolid, España. jbustamantemunguira@gmail.com
authors.forename: Juan
authors.initials: J
authors.lastname: Bustamante
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tamayo
authors.forename: Santiago
authors.initials: S
authors.lastname: Flórez
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Telleria
authors.forename: Elena
authors.initials: E
authors.lastname: Bustamante
authors.forename: Javier
authors.initials: J
authors.lastname: López
authors.forename: J Alberto
authors.initials: JA
authors.lastname: San Román
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Alvarez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D004247:DNA / Q000235:genetics; D004697:Endocarditis, Bacterial / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051193:Toll-Like Receptors / Q000235:genetics
chemical_list: D051195:Toll-Like Receptor 2; D051193:Toll-Like Receptors; D004247:DNA