title: Neurogenesis at the brain-cerebrospinal fluid interface.
abstract: Cerebral cortical progenitor cells can be classified into several different types, and each progenitor type integrates cell-intrinsic and cell-extrinsic cues to regulate neurogenesis. On one hand, cell-intrinsic mechanisms that depend upon appropriate apical-basal polarity are established by adherens junctions and apical complex proteins and are particularly important in progenitors with apical processes contacting the lateral ventricle. The apical protein complexes themselves are concentrated at the ventricular surface, and apical complex proteins regulate mitotic spindle orientation and cell fate. On the other hand, remarkably little is known about how cell-extrinsic cues signal to progenitors and couple with cell-intrinsic mechanisms to instruct neurogenesis. Recent research shows that the cerebrospinal fluid, which contacts apical progenitors at the ventricular surface and bathes the apical complex of these cells, provides growth- and survival-promoting cues for neural progenitor cells in developing and adult brain. This review addresses how the apical-basal polarity of progenitor cells regulates cell fate and allows progenitors to sample diffusible signals distributed by the cerebrospinal fluid. We also review several classes of signaling factors that the cerebrospinal fluid distributes to the developing brain to instruct neurogenesis.
authors.affiliation: Division of Genetics, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA. maria.lehtinen@childrens.harvard.edu
authors.forename: Maria K
authors.initials: MK
authors.lastname: Lehtinen
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Walsh
mesh_terms: D022005:Adherens Junctions / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D016764:Cell Polarity; D049109:Cell Proliferation; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000254:growth & development* / Q000378:metabolism*; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000378:metabolism*; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D014212:Tretinoin / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins; D051880:Receptors, Notch; D014212:Tretinoin