title: Differential effect of clopidogrel and aspirin on the release of BDNF from platelets.
abstract: Anti-platelet treatment is a key therapeutic intervention in patients with cerebrovascular diseases. However, there is no information on its impact on the release of Brain-derived neurotrophic factor (BDNF), which is stored in large amounts in human platelets and essential for neuronal protection and repair. Here, we show that a single oral dose of clopidogrel, but not aspirin, significantly reduced the release of BDNF from platelets in healthy volunteers. These data point, for the first time, to possible differential effects of anti-platelet regimens on neuronal function in patients with cerebrovascular disorders.
authors.affiliation: University of Rostock, Department of Pneumology, Germany. paul.stoll@med.uni-rostock.de
authors.forename: Paul
authors.initials: P
authors.lastname: Stoll
authors.forename: Annett
authors.initials: A
authors.lastname: Plessow
authors.forename: Kai
authors.initials: K
authors.lastname: Bratke
authors.forename: J Christian
authors.initials: JC
authors.lastname: Virchow
authors.forename: Marek
authors.initials: M
authors.lastname: Lommatzsch
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D000077144:Clopidogrel; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019208:Brain-Derived Neurotrophic Factor; D010975:Platelet Aggregation Inhibitors; D053773:Transforming Growth Factor beta1; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin