title: Fast-specific tomography imaging via Cerenkov emission.
abstract: OBJECTIVE
  Development of more tumor-specific radiopharmaceuticals is not enough; to understand the disease, we must study data modeling. Although fluoro-18-deoxyglucose positron emission tomography can map a multi-peak distribution of trace radioisotopes, optical tomography should also be able to redirect the distribution.
  
  
  METHODS
  Multi-view image acquisition of small animals injected with 2-deoxy-2-[(18)F]fluoro-D: -glucose began with X-ray computed tomography scanning and Cerenkov luminescence imaging. After fusion processing, utilization of the geometric row scaling and L                            (1/2) regularization operator effectively generates in vivo Cerenkov luminescence tomography images with the SP(3) forward model.
  
  
  RESULTS
  The identification is confirmed by the comparison between tumor-specific tomography from Cerenkov emission and the radioactivity measured in vitro.
  
  
  CONCLUSIONS
  The proposed technique can quickly localize the mobility of radionuclides and uptake by organs, which provides an imaging methodology in oncology.
authors.affiliation: Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Room 931, Automation Building, No.95 Zhongguancun East Road, Beijing, 100190, China.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Zhong
authors.forename: Chenghu
authors.initials: C
authors.lastname: Qin
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen
authors.forename: Xiang
authors.initials: X
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000818:Animals; D003198:Computer Simulation; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry / Q000493:pharmacokinetics; D008163:Luminescent Measurements / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18