title: CuI/TMEDA-catalyzed annulation of 2-bromo alkynylbenzenes with Na2S: synthesis of benzo[b]thiophenes.
abstract: A copper-catalyzed thiolation annulation reaction of 2-bromo alkynylbenzenes with sodium sulfide has been developed. In the presence of CuI and TMEDA, a variety of 2-substituted benzo[b]thiophenes were readily prepared in moderate to good yields by the reaction of 2-bromo alkynylbenzenes and Na(2)S·9H(2)O.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
authors.forename: Lei-Lei
authors.initials: LL
authors.lastname: Sun
authors.forename: Chen-Liang
authors.initials: CL
authors.lastname: Deng
authors.forename: Ri-Yuan
authors.initials: RY
authors.lastname: Tang
authors.forename: Xing-Guo
authors.initials: XG
authors.lastname: Zhang
mesh_terms: D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D002855:Chromatography, Thin Layer; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013440:Sulfides / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis*
chemical_list: D009942:Organometallic Compounds; D013440:Sulfides; D013876:Thiophenes; C450681:phenyllithium; D001554:Benzene; C033479:sodium sulfide