title: [Comparative study of absorption kinetics in intestines of rats on Xianlinggubao capsule prepared by different technologies].
abstract: OBJECTIVE
  To study the characteristics of intestinal absorption of psoralen and isopsoralen of Xianlinggubao capsule, and compare the absorption of Xianlinggubao capsule prepared by different technologies.
  
  
  METHODS
  Non everted gut sac method was applied to investigate the influence of absorption sites and drug concentration on psoralen and isopsoralen absorption, which were determined by HPLC.
  
  
  RESULTS
  Although the absorption rate constants of psoralen and isopsoralen in duodenum were more than that in jejunum and ileum, there was no significance difference between them. The absorption rate constants of psoralen kept at the same level when the concentrations of drug solution were at middle and low level, while the absorption rate constant at high level was absolutely lower than them (P < 0.05). The results of isopsoralen were the same as psoralen's.
  
  
  CONCLUSIONS
  Intestinal absorption of psoralen and isopsoralen may be affected by the dissolution. The absorption rate constants of psoralen and isopsoralen in new Xianlinggubao capsules are higher. The absorptions of active components absorption has significant difference in different preparation processes of Xianlinggubao capsule.
authors.affiliation: Department of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China. wuhuichao1011@126.com
authors.forename: Huichao
authors.initials: H
authors.lastname: Wu
authors.forename: Shouying
authors.initials: S
authors.lastname: Du
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Ma
authors.forename: Pengyue
authors.initials: P
authors.lastname: Li
mesh_terms: D000818:Animals; D002214:Capsules / Q000493:pharmacokinetics; D004339:Drug Compounding; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics; D004386:Duodenum / Q000378:metabolism; D005363:Ficusin / Q000493:pharmacokinetics*; D011564:Furocoumarins / Q000493:pharmacokinetics*; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D051381:Rats
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D011564:Furocoumarins; C011659:angelicin; D005363:Ficusin