title: Potential cross-talk between (pro)renin receptors and Wnt/frizzled receptors in cardiovascular and renal disorders.
abstract: The renin-angiotensin system and Wnt/frizzled receptor signaling pathways are important in the development of essential organs, and their aberrant activation results in cardiovascular and renal pathologies. The (pro)renin receptor ((P)RR)-bound (pro)renin is enzymatically active generating angiotensin-II and activating mitogen-activated protein kinases, leading to cell proliferation and to upregulation of profibrotic genes expression, resulting in end-organ damage. The (P)RR does more than bind to (pro)renin, because it is functionally linked to the vacuolar-H(+)-ATPase (v-H(+)-ATPase) that regulates pH of cellular and intracellular vesicles, and to Wnt signaling. This signaling pathway is essential for cell survival, embryonic development and has had a role in various disease states as evidenced by mutation or genetic ablation of the (P)RR gene. This suggests two types of functions of (P)RRs, first one as a receptor for (pro)renin and second one as an accessory subunit of the v-H(+)-ATPase and a cofactor of the Wnt/Fz receptor complex. This review will discuss both of these functions of (P)RRs thereby giving new perspectives as to the roles of (P)RRs in cardiovascular and renal pathologies.
authors.affiliation: Cardivascular Pharmacology Division, Department of Pharmacology, Institute of Pharmacy, Rajendra Institute of Technology and Sciences, Sirsa, India.
authors.forename: Pitchai
authors.initials: P
authors.lastname: Balakumar
authors.forename: Gowraganahalli
authors.initials: G
authors.lastname: Jagadeesh
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002470:Cell Survival / Q000502:physiology; D004195:Disease Models, Animal; D051157:Frizzled Receptors / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D020239:Receptor Cross-Talk / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D060490:Receptors, Wnt / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D000093342:Prorenin Receptor
chemical_list: D051157:Frizzled Receptors; D011956:Receptors, Cell Surface; D060490:Receptors, Wnt; D000093342:Prorenin Receptor