title: Synthesis and molecular modeling study of new trimeric quinoline derivatives.
abstract: Di- and trimeric quinoline derivatives have been recently described as potential modulators of Bcl-2 family protein interactions. However, only a few trimeric compounds have been described so far and an enlargement of the number of analogs of this class is needed to expand the structure-activity relationship study. Therefore, the synthesis of six new trimeric quinoline derivatives is reported. Moreover molecular modeling experiments were performed to study the conformational arrangement of compound 36 in Bak binding site of Bcl-x(L), showing that these compounds could be potential ligands for Bcl-x(L).
authors.affiliation: Clermont Université, Université Blaise Pascal, SEESIB, BP 10448, F-63000 Clermont-Ferrand, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Saugues
authors.forename: Lionel
authors.initials: L
authors.lastname: Nauton
authors.forename: Vincent
authors.initials: V
authors.lastname: Théry
authors.forename: Fabrice
authors.initials: F
authors.lastname: Anizon
authors.forename: Pascale
authors.initials: P
authors.lastname: Moreau
mesh_terms: D001665:Binding Sites; D008958:Models, Molecular; D058105:Polymerization; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000378:metabolism; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013329:Structure-Activity Relationship; D050998:bcl-2 Homologous Antagonist-Killer Protein / Q000737:chemistry / Q000378:metabolism; D051020:bcl-X Protein / Q000378:metabolism
chemical_list: C569237:2,2',2''-triethoxy-5,5',5''-triisopropyl-3,7':3,7''-terquinoline; D019253:Proto-Oncogene Proteins c-bcl-2; D011804:Quinolines; D050998:bcl-2 Homologous Antagonist-Killer Protein; D051020:bcl-X Protein; C037219:quinoline