title: Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects.
abstract: The impact of consuming curcuminoids containing curcumin at 500 mg/day and 6 g/day for 7 days on plasma antioxidant capacity and serum cholesterol level were determined by using vitamin E 200 IU/day consumption as a comparison. Group A and group B subjects consumed 500 mg and 6 g curcumin, respectively, but group C subjects consumed vitamin E 200 IU. By using the oxygen radical absorbance capacity (ORAC) assay, it was found that plasma antioxidant capacity of group A rose from a baseline of 13% to 24% on day 1 and day 7, as against a 19-20% increase for group B. Serum cholesterol and triglyceride levels were significantly decreased after curcumin treatment at 500 mg/day. By consuming vitamin E, both ORAC values and plasma α-tocopherol concentrations were significantly increased, but only very slight responses on serum cholesterol or triglyceride levels were observed. It is therefore suggested that curcumin supplement would not be appropriate for healthy people except for reducing serum cholesterol or triglyceride levels. The dosage of a daily curcumin supplement at 500 mg is more effective than 6 g, although vitamin E is also considered to be an effective antioxidant supplement.
authors.affiliation: Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Kanit
authors.initials: K
authors.lastname: Pungcharoenkul
authors.forename: Phensri
authors.initials: P
authors.lastname: Thongnopnua
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood*; D003474:Curcumin / Q000008:administration & dosage*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D000975:Antioxidants; D014280:Triglycerides; D014810:Vitamin E; D002784:Cholesterol; D024502:alpha-Tocopherol; D003474:Curcumin