title: Metabolism and disposition of a novel antineoplastic JS-38 (Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5-bis (trifluoromethyl)-(9Cl)) in rats.
abstract: The metabolism and catabolism of a novel antineoplastic (ID code JS-38),Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5-bis (trifluoromethyl)-(9Cl), were investigated in Wistar rats (3 female, 3 male). LC/UV, LC/MS, LC/MS/MS, NMR and acid hydrolysis methods showed that the metabolic process of JS-38 consists of a series of acetylation and glucoronation that form a metabolic product with a unique pharmacologic property of accelerating bone-marrow cell formation, and also showed a novel metabolic pathway of being acetylated and glucuronated in series.
authors.affiliation: Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, China. hongzh97@yahoo.com.cn
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Quanhai
authors.initials: Q
authors.lastname: Liu
authors.forename: Tingting
authors.initials: T
authors.lastname: Fan
authors.forename: Yu
authors.initials: Y
authors.lastname: Fang
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Guoping
authors.initials: G
authors.lastname: Wang
mesh_terms: D000107:Acetylation; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002853:Chromatography, Liquid / Q000379:methods*; D005260:Female; D020719:Glucuronides / Q000378:metabolism; D006845:Hydrocarbons, Fluorinated / Q000378:metabolism / Q000493:pharmacokinetics*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D053719:Tandem Mass Spectrometry / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D020719:Glucuronides; D006845:Hydrocarbons, Fluorinated; C533647:JS-38 compound