title: Bacterial subversion of host actin dynamics at the plasma membrane.
abstract: Invasion of non-phagocytic cells by a number of bacterial pathogens involves the subversion of the actin cytoskeletal remodelling machinery to produce actin-rich cell surface projections designed to engulf the bacteria. The signalling that occurs to induce these actin-rich structures has considerable overlap among a diverse group of bacteria. The molecular organization within these structures act in concert to internalize the invading pathogen. This dynamic process could be subdivided into three acts - actin recruitment, engulfment, and finally, actin disassembly/internalization. This review will present the current state of knowledge of the molecular processes involved in each stage of bacterial invasion, and provide a perspective that highlights the temporal and spatial control of actin remodelling that occurs during bacterial invasion.
authors.affiliation: Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, UK. r.carabeo@imperial.ac.uk
authors.forename: Rey
authors.initials: R
authors.lastname: Carabeo
mesh_terms: D000199:Actins / Q000378:metabolism*; D001419:Bacteria / Q000472:pathogenicity*; D002462:Cell Membrane / Q000378:metabolism*; D004705:Endocytosis; D054884:Host-Pathogen Interactions; D015398:Signal Transduction
chemical_list: D000199:Actins