title: Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats.
abstract: We have investigated the effect of protein kinase Mzeta (PKMζ) inhibition in the basolateral amygdala (BLA) upon the retention of a nonspatial learned active avoidance response and conditioned taste-aversion (CTA) acquisition in rats. ZIP (10 nmol/μL) injected into the BLA 24 h after training impaired retention of a learned avoidance-jumping response assessed 7 d later when compared with control groups injected with scrambled-ZIP. Nevertheless, a retraining session applied 24 h later indicated no differences between the groups. Additionally, a similar ZIP injection into the BLA during the conditioned stimulus-unconditioned stimulus (CS-US) interval attenuated CTA acquisition. These findings support the BLA PKMζ role in various forms of memory.
authors.affiliation: Department of Experimental Psychology and Physiology of Behaviour, Institute of Neurosciences, Centre for Biomedical Research (CIBM), University of Granada, Campus Cartuja, 18071 Granada, Spain. fernandogamiz@ugr.es
authors.forename: Fernando
authors.initials: F
authors.lastname: Gámiz
authors.forename: Milagros
authors.initials: M
authors.lastname: Gallo
mesh_terms: D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D057846:Cell-Penetrating Peptides; D003214:Conditioning, Classical / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects*; D004195:Disease Models, Animal; D004333:Drug Administration Routes; D005518:Food Preferences / Q000187:drug effects; D055666:Lipopeptides / Q000494:pharmacology; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D009842:Oligopeptides / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012439:Saccharin / Q000008:administration & dosage; D013649:Taste / Q000187:drug effects*
chemical_list: D057846:Cell-Penetrating Peptides; D055666:Lipopeptides; D009842:Oligopeptides; C568285:zeta-inhibitory peptide; D011493:Protein Kinase C; C504730:protein kinase M zeta, rat; D012439:Saccharin