title: Jarid2 regulates mouse epidermal stem cell activation and differentiation.
abstract: Jarid2 is required for the genomic recruitment of the polycomb repressive complex-2 (PRC2) in embryonic stem cells. However, its specific role during late development and adult tissues remains largely uncharacterized. Here, we show that deletion of Jarid2 in mouse epidermis reduces the proliferation and potentiates the differentiation of postnatal epidermal progenitors, without affecting epidermal development. In neonatal epidermis, Jarid2 deficiency reduces H3K27 trimethylation, a chromatin repressive mark, in epidermal differentiation genes previously shown to be targets of the PRC2. However, in adult epidermis Jarid2 depletion does not affect interfollicular epidermal differentiation but results in delayed hair follicle (HF) cycling as a consequence of decreased proliferation of HF stem cells and their progeny. We conclude that Jarid2 is required for the scheduled proliferation of epidermal stem and progenitor cells necessary to maintain epidermal homeostasis.
authors.affiliation: Department of Differentiation and Cancer, Center for Genomic Regulation and UPF, Barcelona, Spain.
authors.forename: Stefania
authors.initials: S
authors.lastname: Mejetta
authors.forename: Lluis
authors.initials: L
authors.lastname: Morey
authors.forename: Gloria
authors.initials: G
authors.lastname: Pascual
authors.forename: Bernd
authors.initials: B
authors.lastname: Kuebler
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Mysliwiec
authors.forename: Youngsook
authors.initials: Y
authors.lastname: Lee
authors.forename: Ramin
authors.initials: R
authors.lastname: Shiekhattar
authors.forename: Luciano
authors.initials: L
authors.lastname: Di Croce
authors.forename: Salvador Aznar
authors.initials: SA
authors.lastname: Benitah
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism; D018859:Hair Follicle / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D063151:Polycomb Repressive Complex 2; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
chemical_list: D006657:Histones; C093650:Jarid2 protein, mouse; D009419:Nerve Tissue Proteins; D063151:Polycomb Repressive Complex 2