title: Adenocarcinoma below stapled ileoanal anastomosis after restorative proctocolectomy for ulcerative colitis.
abstract: A case of adenocarcinoma arising in a 39-year-old patient after restorative proctocolectomy is reported. The patient underwent an ileal pouch-anal anastomosis with double-stapled technique for severe ulcerative colitis 18 years earlier, without evidence of associated neoplasm or dysplasia in operative specimen. After endoscopic diagnosis of adenocarcinoma, the patient was submitted to excision of the pouch and permanent ileostomy, followed by combined radiotherapy and chemotherapy. Pathology showed an AJCC stage III moderately differentiated mucinous adenocarcinoma. The patient died 24 months after the operation, due to cancer progression. There are 50 reported cases in the indexed medical literature of carcinoma arisen after ileal pouch-anal anastomosis for ulcerative colitis. Twenty-five out of these arose after mucosectomy and hand-sewn anastomosis, and 25 after stapling technique. Furthermore, in 48% of the patients, dysplasia or cancer was already present at the time of the colectomy. The increase of reported cases suggests a routine long-term endoscopic surveillance in patients with long-standing ileal pouches, especially in presence of dysplasia or cancer in the proctocolectomy specimen.
authors.affiliation: Department of Surgery, San Camillo-Forlanini Hospitals, Rome, Italy. lalessandroni@scamilloforlanini.rm.it
authors.forename: Luciano
authors.initials: L
authors.lastname: Alessandroni
authors.forename: Anna
authors.initials: A
authors.lastname: Kohn
authors.forename: Massimo
authors.initials: M
authors.lastname: Capaldi
authors.forename: Ilaria
authors.initials: I
authors.lastname: Guadagni
authors.forename: Andrea
authors.initials: A
authors.lastname: Scotti
authors.forename: Roberto
authors.initials: R
authors.lastname: Tersigni
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology* / Q000628:therapy; D000328:Adult; D001003:Anal Canal / Q000473:pathology / Q000601:surgery; D000714:Anastomosis, Surgical / Q000009:adverse effects; D001005:Anus Neoplasms / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003093:Colitis, Ulcerative / Q000601:surgery*; D039021:Colonic Pouches / Q000009:adverse effects*; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D016737:Proctocolectomy, Restorative; D018714:Radiotherapy, Adjuvant; D017792:Surgical Stapling / Q000009:adverse effects