title: Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-ones.
abstract: The palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-one with (het)arylboronic acids allow easy access to (het)aryl and vinyl derivatives of this bicycle in good to excellent yields, even from chloro derivatives. The sequence of reactivity of the halogen in the different positions of the ring system was also investigated. 6-Phenyl-4H-pyrido[1,2-a]pyrimidin-4-one could be prepared by thermal cyclization of isopropylidene (6-phenylpyrid-2-ylamino)methylenemalonate, together with a small amount of 7-phenyl-1,4-dihydro-1,8-naphthyridin-4-one.
authors.affiliation: Chemical Development, R&D, Chinoin Ltd, Tó utca 1-5, H-1045 Budapest, Hungary.
authors.forename: Annamária
authors.initials: A
authors.lastname: Molnár
authors.forename: Anita
authors.initials: A
authors.lastname: Kapros
authors.forename: László
authors.initials: L
authors.lastname: Párkányi
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Mucsi
authors.forename: Gábor
authors.initials: G
authors.lastname: Vlád
authors.forename: István
authors.initials: I
authors.lastname: Hermecz
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry; D011789:Quantum Theory; D013237:Stereoisomerism
chemical_list: D011744:Pyrimidinones; D010165:Palladium