title: PET/CT imaging of clear cell renal cell carcinoma with I labeled chimeric antibody.
abstract: Clear cell renal cell carcinoma (ccRCC) presents problems for urologists in diagnosis, treatment selection, intraoperative surgical margin analysis, and long term monitoring. In this paper we describe the development of a radiolabeled antibody specific to ccRCC (124I-cG250) and its potential to help urologists manage each of these problems. We believe 124I-cG250, in conjunction with perioperative Positron emission tomography/computed tomography imaging and intraoperative handheld gamma probe use, has the potential to diagnose ccRCC, aid in determining a proper course of treatment (operative or otherwise), confirm complete resection of malignant tissue in real time, and monitor patients post-operatively.
authors.affiliation: Department of Radiology, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Eamonn E
authors.initials: EE
authors.lastname: Bahnson
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Murrey
authors.forename: Cathy M
authors.initials: CM
authors.lastname: Mojzisik
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Hall
authors.forename: Humberto J
authors.initials: HJ
authors.lastname: Martinez-Suarez
authors.forename: Michael V
authors.initials: MV
authors.lastname: Knopp
authors.forename: Edward W
authors.initials: EW
authors.lastname: Martin
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Povoski
authors.forename: Robert R
authors.initials: RR
authors.lastname: Bahnson