title: Spontaneous cutaneous umbilical endometriosis: report of a new case with immunohistochemical study and literature review.
abstract: Endometriosis (i.e., the presence of functional endometrial tissue outside the uterine cavity) may rarely affect the skin either spontaneously or secondary to abdomino-pelvic surgery. Spontaneous cutaneous endometriosis appears most commonly on the umbilicus (Villar nodule) and manifests with a red-brown nodule that characteristically shows cyclic variations (tenderness or bleeding) with the menstrual cycle. We present herein a new case of spontaneous cutaneous endometriosis of the umbilicus that was studied immunohistochemically and review the salient clinicopathologic features of this rare condition.
authors.affiliation: Department of Dermatology, Edouard Herriot Hospital Group, Lyon, France.
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Kyamidis
authors.forename: Viviana
authors.initials: V
authors.lastname: Lora
authors.forename: Jean
authors.initials: J
authors.lastname: Kanitakis
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7 / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012871:Skin Diseases / Q000473:pathology* / Q000601:surgery; D014472:Umbilicus / Q000473:pathology*
chemical_list: D053552:Keratin-7; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone