title: Adenosine A(2A) agonists as therapy for glomerulonephritis.
abstract: Garcia et al. report the utility of pharmacological activation of the adenosine A(2A) receptor (A(2A)R) in preserving renal function, reversing fibrosis, and reducing macrophage infiltration and inflammatory activation in rat nephrotoxic nephritis. The role of A(2A)R activation in determining outcome in renal inflammation is discussed.
authors.affiliation: Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK. dferenbach@hotmail.com
authors.forename: David A
authors.initials: DA
authors.lastname: Ferenbach
authors.forename: Jeremy
authors.initials: J
authors.lastname: Hughes
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D058908:Adenosine A2 Receptor Agonists / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D005921:Glomerulonephritis / Q000517:prevention & control*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology*; D043705:Receptor, Adenosine A2A / Q000187:drug effects*
chemical_list: D058908:Adenosine A2 Receptor Agonists; D000893:Anti-Inflammatory Agents; D010627:Phenethylamines; D043705:Receptor, Adenosine A2A; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; D000241:Adenosine