title: Hematopoietic stem and progenitor cell trafficking.
abstract: Migration of hematopoietic stem cells (HSCs) is essential during embryonic development and throughout adult life. During embryogenesis, trafficking of HSCs is responsible for the sequential colonization of different hematopoietic organs by blood-producing cells. In adulthood, circulation of HSCs maintains homeostasis of the hematopoietic system and participates in innate immune responses. HSC trafficking is also crucial in clinical settings such as bone marrow (BM) and stem cell transplantation. This review provides an overview of the molecular and cellular signals that control and fine-tune trafficking of HSCs and hematopoietic progenitor cells in embryogenesis and during postnatal life. We also discuss the potential clinical utility of therapeutic approaches to modulate HSC trafficking in patients.
authors.affiliation: Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
authors.forename: Irina B
authors.initials: IB
authors.lastname: Mazo
authors.forename: Steffen
authors.initials: S
authors.lastname: Massberg
authors.forename: Ulrich H
authors.initials: UH
authors.lastname: von Andrian
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology / Q000276:immunology*; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism; D002465:Cell Movement / Q000276:immunology*; D058948:Cell Tracking; D004622:Embryo, Mammalian; D047108:Embryonic Development / Q000276:immunology; D005260:Female; D053686:Fetal Stem Cells / Q000166:cytology / Q000276:immunology*; D005333:Fetus; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007158:Immunologic Techniques; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D051379:Mice; D019038:Platelet Glycoprotein GPIb-IX Complex; D011247:Pregnancy
chemical_list: D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D019038:Platelet Glycoprotein GPIb-IX Complex; C094990:adhesion receptor