title: Investigation of the association between dopamine D1 receptor gene polymorphisms and essential hypertension in a group of Turkish subjects.
abstract: Dopamine has been shown to influence blood pressure by regulating renal sodium excretion through direct interaction with the dopamine receptors, especially with the Dopamine D1 receptor (DRD1). To better understand the role of polymorphisms in those effects, we investigated the association between two polymorphic sites in the DRD1 promoter region (A-48G, G-94A) and essential hypertension in the Turkish population. The DRD1 variants were genotyped by restriction fragment length polymorphism (RFLP) analysis. A total of 205 unrelated individuals were enrolled in the study. We found that genotype distributions and allele frequencies of the control and hypertensive subjects were very similar and did not show any significant difference with respect to blood pressure (BP) and hypertension. Contribution of the gene variances in BP or hypertension by sex differences and dependence on body mass index (BMI) were also evaluated. Distribution of genotypes and allele frequencies were found to be in line with previous reports. However, increments detected in hypertensive subjects were far from being statistically significant.
authors.affiliation: Marmara University School of Medicine, Department of Biophysics, Istanbul, Turkey. oyaorun@yahoo.com
authors.forename: Oya
authors.initials: O
authors.lastname: Orun
authors.forename: Cevdet
authors.initials: C
authors.lastname: Nacar
authors.forename: Hülya
authors.initials: H
authors.lastname: Cabadak
authors.forename: Pınar Mega
authors.initials: PM
authors.lastname: Tiber
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Doğan
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Güneysel
authors.forename: Ali Serdar
authors.initials: AS
authors.lastname: Fak
authors.forename: Beki
authors.initials: B
authors.lastname: Kan
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D012307:Risk Factors; D012727:Sex Characteristics; D014421:Turkey
chemical_list: D017447:Receptors, Dopamine D1