title: Regulation and protection of mitochondrial physiology by sirtuins.
abstract: The link between sirtuin activity and mitochondrial biology has recently emerged as an important field. This conserved family of NAD(+)-dependent deacetylase proteins has been described to be particularly involved in metabolism and longevity. Recent studies on protein acetylation have uncovered a high number of acetylated mitochondrial proteins indicating that acetylation/deacetylation processes may be important not only for the regulation of mitochondrial homeostasis but also for metabolic dysfunction in the context of various diseases such as metabolic syndrome/diabetes and cancer. The functional involvement of sirtuins as sensors of the redox/nutritional state of mitochondria and their role in mitochondrial protection against stress are hereby described, suggesting that pharmacological manipulation of sirtuins is a viable strategy against several pathologies.
authors.affiliation: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.
authors.forename: Claudia V
authors.initials: CV
authors.lastname: Pereira
authors.forename: Magda
authors.initials: M
authors.lastname: Lebiedzinska
authors.forename: Mariusz R
authors.initials: MR
authors.lastname: Wieckowski
authors.forename: Paulo J
authors.initials: PJ
authors.lastname: Oliveira
mesh_terms: D000107:Acetylation; D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D024101:Mitochondrial Proteins; D037761:Sirtuins