title: Toll-like receptor 4 polymorphisms in dengue virus-infected children.
abstract: Differential viral recognition by cells bearing Toll-like receptor 4 (TLR4) polymorphisms Asp299Gly and Thr399Ile may influence susceptibility and severity of dengue virus infection. In central Java, Indonesia, we investigated 201 children with dengue hemorrhagic fever (DHF) and 179 healthy controls. Patients and controls were mostly ethnic Javanese. A nearly complete cosegregation of the two mutations was observed. The TLR4 299/399 genotype was found in five patients and four controls. Prevalence of the TLR4 299/399 genotype did not differ significantly between controls and DHF patients or between patients with different severities of DHF. Also, vascular leakage in patients with different TLR4 genotypes did not differ. Thus, the 299/399 TLR4 haplotype has only minor influence on susceptibility and severity of complicated dengue virus infection.
authors.affiliation: Department of Parasitology, Diponegoro University, Semarang, Indonesia. ramus64@yahoo.com
authors.forename: Kis
authors.initials: K
authors.lastname: Djamiatun
authors.forename: Bart
authors.initials: B
authors.lastname: Ferwerda
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
authors.forename: André J A M
authors.initials: AJ
authors.lastname: van der Ven
authors.forename: Wil M V
authors.initials: WM
authors.lastname: Dolmans
authors.forename: Sultana M H
authors.initials: SM
authors.lastname: Faradz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003715:Dengue / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D011110:Polymorphism, Genetic; D051197:Toll-Like Receptor 4 / Q000235:genetics* / Q000378:metabolism
chemical_list: C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4