title: Pelvic organ prolapse and collagen-associated disorders.
abstract: OBJECTIVE
  Pelvic organ prolapse (POP) and other disorders, such as varicose veins and joint hypermobility, have been associated with changes in collagen strength and metabolism. We hypothesized that these various disorders were more prevalent in both POP patients and their family members.
  
  
  METHODS
  In this study, the prevalence of various collagen-associated disorders, including POP, was compared between POP patients (n = 110) and control patients (n = 100) and their first and second degree family members.
  
  
  RESULTS
  POP patients reported a higher prevalence of varicose veins, joint hypermobility and rectal prolapse and were more likely to have family members with POP as compared to the control group (p < 0.01). In contrast, the family members of the POP group did not report a higher prevalence of collagen-associated disorders compared to the family members of the control group (p = 0.82).
  
  
  CONCLUSIONS
  POP and other collagen-associated disorders may have a common aetiology, originating at the molecular level of the collagens.
authors.affiliation: Department of Obstetrics and Gynaecology (791), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands. K.Lammers@obgyn.umcn.nl
authors.forename: Karin
authors.initials: K
authors.lastname: Lammers
authors.forename: Sabrina L
authors.initials: SL
authors.lastname: Lince
authors.forename: Marian A
authors.initials: MA
authors.lastname: Spath
authors.forename: Léon C L T
authors.initials: LC
authors.lastname: van Kempen
authors.forename: Jan C M
authors.initials: JC
authors.lastname: Hendriks
authors.forename: Mark E
authors.initials: ME
authors.lastname: Vierhout
authors.forename: Kirsten B
authors.initials: KB
authors.lastname: Kluivers
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D003095:Collagen Diseases / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D007593:Joint Instability / Q000453:epidemiology*; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D056887:Pelvic Organ Prolapse / Q000453:epidemiology*; D015995:Prevalence; D014648:Varicose Veins / Q000453:epidemiology*