title: Change of BMD after weaning or resumption of menstruation in Chinese women with different FokI VDR-genotypes: a randomized, placebo-controlled, calcium supplementation trial.
abstract: OBJECTIVE
  To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different FokI vitamin D receptor (VDR) genotypes (FF, Ff, and ff) after weaning or resumption of menstruation during lactation.
  
  
  METHODS
  A total of 40 subjects with the same FokI VDR genotype were randomly divided into two groups: one received calcium tablet (600 mg once daily as CaCO(3)) and the other placebo tablet once daily for 1 year. At baseline, BMD was measured by dual-energy X-ray absorptiometry at lumbar spine (L2-L4) and at left hip whereas serum PICP, serum OC, and urinary CTX, serum 25(OH)VitD(3), and serum estradiol were measured at weaning and 1 year thereafter.
  
  
  RESULTS
  After the intervention, BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different FokI VDR genotypes such as FF > Ff > ff (P<0.05, <0.01, and <0.001, respectively). BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype (P<0.05). Compared with the control group women with the FF genotype regained more BMD after calcium supplementation (P<0.05).
  
  
  CONCLUSIONS
  Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype.
authors.affiliation: National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China. yuboshi@263.com
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Hongying
authors.initials: H
authors.lastname: Wu
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Gong
authors.forename: Dunjin
authors.initials: D
authors.lastname: Zhou
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Yang
authors.forename: Zhenwu
authors.initials: Z
authors.lastname: Huang
mesh_terms: D000328:Adult; D044466:Asian People; D015519:Bone Density / Q000187:drug effects*; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005838:Genotype; D006801:Humans; D008598:Menstruation / Q000502:physiology*; D014886:Weaning; D055815:Young Adult
chemical_list: D002136:Calcium, Dietary