title: C-reactive protein may represent sensitive measure of renal cell carcinoma metastasis.
abstract: A patient with localized kidney cancer underwent potentially curative nephrectomy. Routinely post-operative serum C-Reactive Protein (CRP) values were measured. At 25 months post-operatively, lung imaging suggested possible metastasis. However, CRP levels remained at baseline. Subsequent resection revealed a benign mass. CRP values have been shown to carry prognostic significance for overall and disease free survival. This case suggests a novel use for CRP: a sensitive biomarker of disease recurrence and metastasis.
authors.affiliation: Department of Urology, Emory University, Atlanta, GA, USA.
authors.forename: Timothy V
authors.initials: TV
authors.lastname: Johnson
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Young
authors.forename: Seth
authors.initials: S
authors.lastname: Force
authors.forename: Viraj A
authors.initials: VA
authors.lastname: Master
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary; D008297:Male; D009362:Neoplasm Metastasis / Q000175:diagnosis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D011182:Postoperative Care
chemical_list: D014408:Biomarkers, Tumor; D002097:C-Reactive Protein