title: Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease.
abstract: Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ(2) = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.
authors.affiliation: Mediterranean Institute for Life Science, Split, Croatia.
authors.forename: Vinko
authors.initials: V
authors.lastname: Palada
authors.forename: Janoš
authors.initials: J
authors.lastname: Terzić
authors.forename: Joseph
authors.initials: J
authors.lastname: Mazzulli
authors.forename: Grace
authors.initials: G
authors.lastname: Bwala
authors.forename: Johann
authors.initials: J
authors.lastname: Hagenah
authors.forename: Borut
authors.initials: B
authors.lastname: Peterlin
authors.forename: Albert Y
authors.initials: AY
authors.lastname: Hung
authors.forename: Christine
authors.initials: C
authors.lastname: Klein
authors.forename: Dimitri
authors.initials: D
authors.lastname: Krainc
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006637:Histamine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D007532:Isoleucine / Q000235:genetics*; D008297:Male; D015201:Meta-Analysis as Topic; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013912:Threonine / Q000235:genetics*; D044465:White People
chemical_list: D007532:Isoleucine; D013912:Threonine; D006637:Histamine N-Methyltransferase