title: [Citrullinated proteins in rheumatoid arthritis].
abstract: Rheumatoid arthritis is an autoimmune disease of multifactorial etiology characterized by inflammation of the joints and presence of autoantibodies directed against multiple autoantigens. Recently the study of the anti-citrullinated protein antibodies (ACP) has acquired great interest due to its high specificity and sensitivity for diagnosis, in addition to which it has shown to be a predictor of severity in patients with rheumatoid arthritis, suggesting an important participation in the pathogenesis of the disease.
authors.affiliation: Laboratorio de Inmunología, Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., México.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Olivares Martínez
authors.forename: Diego F
authors.initials: DF
authors.lastname: Hernández Ramírez
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Núñez-Álvarez
authors.forename: Javier
authors.initials: J
authors.lastname: Cabiedes
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D001120:Arginine / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology* / Q000378:metabolism; D015415:Biomarkers; D014408:Biomarkers, Tumor / Q000276:immunology / Q000378:metabolism; D002956:Citrulline / Q000378:metabolism*; D024043:Collagen Type II / Q000276:immunology / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D005340:Fibrinogen / Q000276:immunology / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000276:immunology / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases; D051381:Rats; D011917:Rats, Inbred Lew; D012680:Sensitivity and Specificity; D013379:Substrate Specificity; D025521:Tumor Suppressor Proteins / Q000276:immunology / Q000378:metabolism; D014746:Vimentin / Q000276:immunology / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D014408:Biomarkers, Tumor; D024043:Collagen Type II; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; D014746:Vimentin; D002956:Citrulline; D005340:Fibrinogen; D001120:Arginine; D006867:Hydrolases; C000629235:PADI4 protein, human; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases; C095157:ENO1 protein, human; D010751:Phosphopyruvate Hydratase