title: Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs.
abstract: The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology.
authors.affiliation: College of Pharmacy, Korea University, Jochiwon, Yeongi, Chungnam 339-700, Republic of Korea.
authors.forename: Soon Hong
authors.initials: SH
authors.lastname: Yuk
authors.forename: Keun Sang
authors.initials: KS
authors.lastname: Oh
authors.forename: Heebeom
authors.initials: H
authors.lastname: Koo
authors.forename: Hyesung
authors.initials: H
authors.lastname: Jeon
authors.forename: Kwangmeyung
authors.initials: K
authors.lastname: Kim
authors.forename: Ick Chan
authors.initials: IC
authors.lastname: Kwon
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D020285:Cryoelectron Microscopy; D000077143:Docetaxel; D016503:Drug Delivery Systems; D008561:Membrane Fusion / Q000187:drug effects; D051379:Mice; D053758:Nanoparticles / Q000648:ultrastructure; D010316:Particle Size; D019265:Spectroscopy, Near-Infrared; D043823:Taxoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome; D053835:Unilamellar Liposomes / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D053835:Unilamellar Liposomes; D000077143:Docetaxel