title: [Cycloferon administration in chronic pyelonephritis: changes in interferon status].
abstract: OBJECTIVE
  To detect correlations between changes in interferon (INF) system and a course of chronic pyelonephritis (CP), to ascertain a corrective effect of cyclopheron in combined treatment with antibacterial drugs.
  
  
  METHODS
  We examined 30 CP patients in different periods of the disease: group 1 had latent CP without laboratory evidence for exacerbation, group 2 had CP exacerbation treated with antibiotics, group 3 had exacerbation given basic treatment and cyclopheron by a standard scheme. All the patients were examined for interferon status, patients of groups 2 and 3 were examined once more after therapy.
  
  
  RESULTS
  Patients of all the groups showed diminished ability of blood leukocytes to produce IFN, especially IFN-gamma. Cyclopheron addition to antibacterial therapy significantly stimulated production of IFN alpha and gamma by blood cells compared to basic therapy. Examination of 5 patients after 1-year follow-up detected preserved ability of blood cells to produce IFN and reduce the number of exacerbations after combined treatment with cyclopheron.
  
  
  CONCLUSIONS
  Administration of cyclopheron in combination with standard antibacterial treatment results in persistent correction of IFN status.
authors.forename: I P
authors.initials: IP
authors.lastname: Kudriashova
authors.forename: T P
authors.initials: TP
authors.lastname: Ospel'nikova
authors.forename: F I
authors.initials: FI
authors.lastname: Ershov
mesh_terms: D000166:Acridines / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007369:Interferon Inducers / Q000008:administration & dosage / Q000627:therapeutic use*; D007372:Interferons / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000188:drug therapy* / Q000276:immunology; D055815:Young Adult
chemical_list: D000166:Acridines; D000900:Anti-Bacterial Agents; D007369:Interferon Inducers; D007372:Interferons; C026430:10-carboxymethyl-9-acridanone