title: Seropositive antiaquaporin-4 antibody associated with multisegmental myelitis in a patient with paracoccidioidomycosis.
abstract: Since the description of the association between neuromyelitis optica (Devic's disease) and aquaporin 4 IgG antibody (NMO-IgG), the search for this antibody has been considered a highly recommended laboratory test when centromedullary multisegmental lesions are observed by magnetic resonance imaging (MRI). Such MRI lesions have not been confined to acute NMO myelitis because other infectious and post-infectious disorders may display a similar lesional pattern. However, NMO-IgG has not been currently searched and associated with these myelitides. The objective of this study is to report an infectious myelitis that tested positive for NMO-IgG and comment on the implications of this finding. We report the presence of NMO-IgG in one patient exhibiting centromedullary multisegmental lesions who presented Paracoccidioides brasiliensis myelitis.
authors.affiliation: Department of Neurosciences, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
authors.forename: Doralina Guimarães
authors.initials: DG
authors.lastname: Brum
authors.forename: Eduardo Antônio
authors.initials: EA
authors.lastname: Donadi
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: dos Santos
authors.forename: Osvaldo Massaiti
authors.initials: OM
authors.lastname: Takayanagui
authors.forename: Wilson
authors.initials: W
authors.lastname: Marques
authors.forename: Amilton Antunes
authors.initials: AA
authors.lastname: Barreira
mesh_terms: D000908:Antibodies, Fungal / Q000096:biosynthesis / Q000097:blood*; D051401:Aquaporin 4 / Q000097:blood* / Q000276:immunology; D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009187:Myelitis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D010229:Paracoccidioidomycosis / Q000097:blood* / Q000150:complications / Q000175:diagnosis
chemical_list: D000908:Antibodies, Fungal; D051401:Aquaporin 4; D001323:Autoantibodies