title: The radioguided 111In-pentetreotide surgery in the management of ACTH-secreting bronchial carcinoid.
abstract: OBJECTIVE
  A correct intra-operative detection of the tumour and, therefore, the complete surgical resection is critical to success in ACTH-secreting bronchial carcinoids. To date, all available preoperative and intra-operative procedures remain not entirely satisfactory. The use of intra-operative 111In-pentetreotide detection could offer a potentially reliable and rapid tool of real time assessment to achieve a radical resection.
  
  
  METHODS
  In two cases of ACTH-secreting bronchial carcinoids, after a preliminary 111In-pentetreotide scan, radio-guided surgery was performed using a hand-held gamma probe 24 h after i.v. administration of the tracer.
  
  
  RESULTS
  The 111n-pentetreotide radioguided surgery with hand-held gamma probe, if compared with pre-operative 111In-pentetreotide, significantly improved the intra-operative surgical management by detecting a millimetric nodule in one case; detecting mediastinal lymph node metastasis in both cases and ruling out any other disease localization.
  
  
  CONCLUSIONS
  Intra-operative 111In-pentetreotide detection appears to be safe and easy to perform. This technique allowed to achieve a complete resection of all the tumor locations, that would have been impossible to detect with conventional surgical approach. On the basis of these results we advocate for a wider investigation of the potentialities connected with the radioguided surgery coupled with pre-operative 111In-pentetreotide scan as a promising procedure in the management of ACTH-secreting bronchial carcinoids.
authors.affiliation: Division of General Thoracic Surgery, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Porziella
authors.forename: A
authors.initials: A
authors.lastname: Cesario
authors.forename: F
authors.initials: F
authors.lastname: Lococo
authors.forename: S
authors.initials: S
authors.lastname: Cafarotti
authors.forename: S
authors.initials: S
authors.lastname: Margaritora
authors.forename: G
authors.initials: G
authors.lastname: D'Errico
authors.forename: P
authors.initials: P
authors.lastname: Granone
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D001984:Bronchial Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D002276:Carcinoid Tumor / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D003480:Cushing Syndrome / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum; D011877:Radionuclide Imaging; D013004:Somatostatin / Q000031:analogs & derivatives*; D016896:Treatment Outcome
chemical_list: D007205:Indium Radioisotopes; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; C081788:pentetreotide