title: Synthesis of fully substituted polyhydroxylated pyrrolizidines via Cope-House cyclization.
abstract: Total synthesis of the proposed structure of (-)-hyacinthacine C(5) and its epimers at C6 and C7 is described. A key step of the synthesis was the construction of the bicyclic pyrrolizidine system by means of a nucleophilic addition of a dithiane to a cyclic nitrone followed by a Cope-House cyclization.
authors.affiliation: Beijing National Laboratory for Molecular Science (BNLMS), Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Kasumi
authors.initials: K
authors.lastname: Sato
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kato
authors.forename: Yue-Mei
authors.initials: YM
authors.lastname: Jia
authors.forename: Xiang-Guo
authors.initials: XG
authors.lastname: Hu
authors.forename: Francis X
authors.initials: FX
authors.lastname: Wilson
authors.forename: Renate
authors.initials: R
authors.lastname: van Well
authors.forename: Graeme
authors.initials: G
authors.lastname: Horne
authors.forename: George W J
authors.initials: GW
authors.lastname: Fleet
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Nash
authors.forename: Chu-Yi
authors.initials: CY
authors.lastname: Yu
mesh_terms: D003500:Cyclization; D006900:Hydroxylation; D015394:Molecular Structure; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis*
chemical_list: D011763:Pyrrolizidine Alkaloids