title: A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene.
abstract: Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.
authors.affiliation: Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Aarhus, Denmark. noomigregersen@mac.com
authors.forename: Noomi
authors.initials: N
authors.lastname: Gregersen
authors.forename: Hans A
authors.initials: HA
authors.lastname: Dahl
authors.forename: Henriette N
authors.initials: HN
authors.lastname: Buttenschøn
authors.forename: Mette
authors.initials: M
authors.lastname: Nyegaard
authors.forename: Anne
authors.initials: A
authors.lastname: Hedemand
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Als
authors.forename: August G
authors.initials: AG
authors.lastname: Wang
authors.forename: Sofus
authors.initials: S
authors.lastname: Joensen
authors.forename: David Pd
authors.initials: DP
authors.lastname: Woldbye
authors.forename: Pernille
authors.initials: P
authors.lastname: Koefoed
authors.forename: Ann S
authors.initials: AS
authors.lastname: Kristensen
authors.forename: Torben A
authors.initials: TA
authors.lastname: Kruse
authors.forename: Anders D
authors.initials: AD
authors.lastname: Børglum
authors.forename: Ole
authors.initials: O
authors.lastname: Mors
mesh_terms: D062565:Acid Sensing Ion Channels; D000483:Alleles; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D062626:Degenerin Sodium Channels; D003718:Denmark / Q000453:epidemiology / Q000208:ethnology; D053503:Epithelial Sodium Channels / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D018895:Microsatellite Repeats; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016584:Panic Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups / Q000235:genetics
chemical_list: C568424:ASIC2 protein, human; D062565:Acid Sensing Ion Channels; D062626:Degenerin Sodium Channels; D053503:Epithelial Sodium Channels; D009419:Nerve Tissue Proteins