title: [The relationship between the serum ET and resistin concentration and the peripheral neuropathy in type 2 diabetes].
abstract: OBJECTIVE
  To study patients with type 2 diabetes, endothelin (ET), resistin level and peripheral neuropathy (DPN) relationship.
  
  
  METHODS
  Second affiliated hospital of Zhengzhou university, department of endocrinology hospital of 60 patients with type 2 diabetes, the nerve electrophysiological examination of 20 cases were divided into DM group and 40 patients with DPN, and select the healthy control group of 30 cases. Radioimmunoassay and enzyme-linked immunosorbent assay of serum ET, resistin levels.
  
  
  RESULTS
  The DM group and the DPN serum ET, resistin levels were significantly higher (P<0.05), while the DPN group ET, resistin levels were significantly higher than that of DM group (P<0.05). Linear correlation analysis showed that patients with type 2 diabetes serum resistin levels were positively correlated with ET (r=0.436, P<0.01). Logistic regression analysis showed that duration, HbA1c, serum resistin level in ET and be associated with DPN are independent risk factors.
  
  
  CONCLUSIONS
  Patients with type 2 diabetes ET, resistin levels are closely related with the DPN; patients with ET, is the abnormal increase of resistin levels may lead to the risk factors of DPN.
authors.affiliation: Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. lylimeiwang@live.cn
authors.forename: Li-mei
authors.initials: LM
authors.lastname: Wang
authors.forename: Chong-xian
authors.initials: CX
authors.lastname: Wang
authors.forename: Dong-ming
authors.initials: DM
authors.lastname: Zhang
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Xie
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000097:blood*; D052243:Resistin / Q000097:blood*; D012307:Risk Factors
chemical_list: D016232:Endothelins; D052243:Resistin