title: Isotopic labelling studies for a gold-catalysed skeletal rearrangement of alkynyl aziridines.
abstract: Isotopic labelling studies were performed to probe a proposed 1,2-aryl shift in the gold-catalysed cycloisomerisation of alkynyl aziridines into 2,4-disubstituted pyrroles. Two isotopomers of the expected skeletal rearrangement product were identified using (13)C-labelling and led to a revised mechanism featuring two distinct skeletal rearrangements. The mechanistic proposal has been rationalised against the reaction of a range of (13)C- and deuterium-labelled substrates.
authors.affiliation: School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Davies
authors.forename: Nicolas
authors.initials: N
authors.lastname: Martin
authors.forename: Neil
authors.initials: N
authors.lastname: Spencer