title: Direct inhibitors of thrombin and factor Xa attenuate clot-induced mitogenesis and inflammatory gene expression in human vascular smooth muscle cells.
authors.forename: Anke C
authors.initials: AC
authors.lastname: Rosenkranz
authors.forename: Karsten
authors.initials: K
authors.lastname: Schrör
authors.forename: Bernhard H
authors.initials: BH
authors.lastname: Rauch
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology; D000991:Antithrombins / Q000494:pharmacology; D001011:Aorta / Q000473:pathology; D001777:Blood Coagulation / Q000187:drug effects / Q000235:genetics; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects; D015951:Factor Xa / Q000378:metabolism*; D065427:Factor Xa Inhibitors; D005786:Gene Expression Regulation / Q000187:drug effects / Q000276:immunology; D006629:Hirudins / Q000494:pharmacology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D009025:Morpholines / Q000494:pharmacology; D032389:Myocytes, Smooth Muscle / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009281:Naphthalenes / Q000494:pharmacology; D011422:Propionates / Q000494:pharmacology; D000069552:Rivaroxaban; D013876:Thiophenes / Q000494:pharmacology; D013917:Thrombin / Q000378:metabolism*
chemical_list: C086910:(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid; D000925:Anticoagulants; D000991:Antithrombins; D065427:Factor Xa Inhibitors; D006629:Hirudins; D018836:Inflammation Mediators; D009025:Morpholines; D009281:Naphthalenes; D011422:Propionates; D013876:Thiophenes; D004247:DNA; D000069552:Rivaroxaban; D013917:Thrombin; D015951:Factor Xa