title: Glucagon test in insulinoma: Is it useful?
abstract: Diagnosis of endogenous hyperinsulinism caused by insulinoma is based on confirmation of hypoglycemia during the symptoms associated to elevated insulin levels. Patients with insulinoma may demonstrate an excessive insulin response and subsequent hypoglycemia after 1 mg of glucagon iv injection. Glucagon test was performed in 11 patients with insulinoma before therapy and in 4 after therapy. Our study suggests that the presence of plasma glucose levels less than 55 mg/dl and below baseline at time 120 min of glucagon test strongly reinforce the diagnosis of insulinoma.
authors.affiliation: Endocrinology Division, Brigadeiro Hospital, São Paulo, Brazil.
authors.forename: J S
authors.initials: JS
authors.lastname: Felício
authors.forename: C L L P
authors.initials: CL
authors.lastname: Martins
authors.forename: K B
authors.initials: KB
authors.lastname: Mileo
authors.forename: M
authors.initials: M
authors.lastname: Semer
authors.forename: L
authors.initials: L
authors.lastname: Kalinin
authors.forename: M
authors.initials: M
authors.lastname: Nery
authors.forename: M C C
authors.initials: MC
authors.lastname: Machado
authors.forename: B
authors.initials: B
authors.lastname: Liberman
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005934:Glucagon; D006728:Hormones; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood; D007003:Hypoglycemia / Q000175:diagnosis; D007328:Insulin / Q000378:metabolism; D007340:Insulinoma / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D011863:Radioimmunoassay; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006728:Hormones; D007328:Insulin; D005934:Glucagon