title: Circulating soluble CD30 and future risk of lymphoma; evidence from two prospective studies in the general population.
abstract: BACKGROUND
  Elevated circulating soluble CD30 (sCD30) has been previously associated with AIDS-related non-Hodgkin lymphoma (NHL) risk. This finding was recently extended to the general population where elevated levels of sCD30 were reported in prediagnostic serum among subjects that developed NHL later in life.
  
  
  METHODS
  We carried out a replication study within the Italian European Prospective Investigation into Cancer and Nutrition cohort. Plasma sCD30 concentration was measured by ELISA in prospectively collected blood of 35 B-cell lymphoma cases and 36 matched controls.
  
  
  RESULTS
  We observed significantly increased relative risks for lymphoma with increasing sCD30 levels [OR (95% CI) for second and third tertiles vs. first tertile: 5.5 (1.5-20.2), 4.0 (1.1-13.9), respectively]. In addition, spline analyses showed that the dose-response curve of sCD30 and lymphoma risk was monotonic and quite similar to the risks reported in the previous study.
  
  
  CONCLUSIONS
  This replication study adds to the evidence that sCD30 is related to future lymphoma risk in a concentration-dependent manner in the general population.
  
  
  CONCLUSIONS
  The results of this study strengthen the observation that chronic sustained B-cell activation plays an important role in lymphomagenesis.
authors.affiliation: Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Jenalaan 18D, 3584 CK Utrecht, The Netherlands. R.C.H.Vermeulen@uu.nl
authors.forename: Roel
authors.initials: R
authors.lastname: Vermeulen
authors.forename: Fatemeh Saberi
authors.initials: FS
authors.lastname: Hosnijeh
authors.forename: Lützen
authors.initials: L
authors.lastname: Portengen
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacredote
authors.forename: Mark
authors.initials: M
authors.lastname: Purdue
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D008223:Lymphoma / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D017730:Ki-1 Antigen