title: Amine-promoted β-elimination of a β-aryloxy aldehyde for fluorogenic chemodosimeters.
abstract: We previously reported a fluorescent chemodosimeter for ozone. The β-elimination step after the ozonolysis of the chemodosimeter was too slow to be practical for real-time monitoring of ozone. We examined primary, secondary, and tertiary amines at various pHs. It was found that pyrrolidine in pH 9 buffer could accelerate the elimination to generate a fluorescence signal. The elimination step is now sufficiently rapid to monitor ozone exposure in real time. We also discovered that azetidine was distinctly effective for the same elimination reaction in a pH 6 buffer.
authors.affiliation: Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA.
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Leslie
authors.forename: Dandan
authors.initials: D
authors.lastname: Li
authors.forename: Kazunori
authors.initials: K
authors.lastname: Koide
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002021:Buffers; D005456:Fluorescent Dyes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D015394:Molecular Structure; D010126:Ozone / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000588:Amines; D002021:Buffers; D005456:Fluorescent Dyes; D010126:Ozone