title: Effects of chronic aluminum exposure on memory through multiple signal transduction pathways.
abstract: OBJECTIVE
  To investigate the effects of chronic aluminum (Al) exposure on memory of rats by recording long-term potentiation (LTP) induction in CA1 region of Schaffer collateral (SC) of hippocampus and observing the changes of key LTP induction-related kinases.
  
  
  METHODS
  Forty weaned Wistar rats were divided into 4 groups ad libitum, each group 10 rats. Three groups were fed with 0.2%, 0.4% and 0.6% AlCl(3) in drinking water for three months individually to set up the aluminum exposure models and the rest group was the control. After behavioral test, electrophysiological recordings were made at area CA1 from hippocampal SC branch followed by biochemical examination for several key kinases involved in LTP induction and formation.
  
  
  RESULTS
  Chronic exposure of Al significantly decrease the activities of protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) and reduced the expression levels of extracellular signal-regulated kinases (ERK1/2) and Ca(2+)-calmodulin dependent protein kinase II (CaMKII) in hippocampus, attenuating the population spike (PS) amplitude of LTP from the hippocampal CA1 region, causing impaired memory abilities of rats.
  
  
  CONCLUSIONS
  Aluminum accumulation in the hippocampus affects several crucial kinases involved in LTP induction and formation, resulting in impairment of memory.
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences of China Medical University, No. 92, Beier Road, Heping District, Shenyang 110001, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xing
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Deng