title: Consensus document: antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting. A North-American perspective.
abstract: The optimal regimen of the anticoagulant and antiplatelet therapies in patients with atrial fibrillation who have had a coronary stent is unclear. It is well recognised that "triple therapy" with aspirin, clopidogrel, and warfarin is associated with an increased risk of bleeding. National guidelines have not made specific recommendations given the lack of adequate data. In choosing the best antithrombotic options for a patient, consideration needs to be given to the risks of stroke, stent thrombosis and major bleeding. This document describes these risks, provides specific recommendations concerning vascular access, stent choice, concomitant use of proton-pump inhibitors and the use and duration of triple therapy following stent placement based upon the risk assessment.
authors.affiliation: Division of Cardiology, Brigham and Women's Hospital, 1620 Tremont Street, OBC-3-12J, Boston, MA 02120, USA. dfaxon@partners.org
authors.forename: David P
authors.initials: DP
authors.lastname: Faxon
authors.forename: John W
authors.initials: JW
authors.lastname: Eikelboom
authors.forename: Peter B
authors.initials: PB
authors.lastname: Berger
authors.forename: David R
authors.initials: DR
authors.lastname: Holmes
authors.forename: Deepak L
authors.initials: DL
authors.lastname: Bhatt
authors.forename: David J
authors.initials: DJ
authors.lastname: Moliterno
authors.forename: Richard C
authors.initials: RC
authors.lastname: Becker
authors.forename: Dominick J
authors.initials: DJ
authors.lastname: Angiolillo
mesh_terms: D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D003245:Consensus Statements as Topic; D003331:Coronary Vessels / Q000601:surgery; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D009656:North America; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D011183:Postoperative Complications; D012306:Risk; D015607:Stents / Q000706:statistics & numerical data; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D014859:Warfarin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D010975:Platelet Aggregation Inhibitors; D014859:Warfarin