title: Differential neural responses to food images in women with bulimia versus anorexia nervosa.
abstract: BACKGROUND
  Previous fMRI studies show that women with eating disorders (ED) have differential neural activation to viewing food images. However, despite clinical differences in their responses to food, differential neural activation to thinking about eating food, between women with anorexia nervosa (AN) and bulimia nervosa (BN) is not known.
  
  
  METHODS
  We compare 50 women (8 with BN, 18 with AN and 24 age-matched healthy controls [HC]) while they view food images during functional Magnetic Resonance Imaging (fMRI).
  
  
  RESULTS
  In response to food (vs non-food) images, women with BN showed greater neural activation in the visual cortex, right dorsolateral prefrontal cortex, right insular cortex and precentral gyrus, women with AN showed greater activation in the right dorsolateral prefrontal cortex, cerebellum and right precuneus. HC women activated the cerebellum, right insular cortex, right medial temporal lobe and left caudate. Direct comparisons revealed that compared to HC, the BN group showed relative deactivation in the bilateral superior temporal gyrus/insula, and visual cortex, and compared to AN had relative deactivation in the parietal lobe and dorsal posterior cingulate cortex, but greater activation in the caudate, superior temporal gyrus, right insula and supplementary motor area.
  
  
  CONCLUSIONS
  Women with AN and BN activate top-down cognitive control in response to food images, yet women with BN have increased activation in reward and somatosensory regions, which might impinge on cognitive control over food consumption and binge eating.
authors.affiliation: Department of Neuroscience, Uppsala University, Uppsala, Sweden. Samantha.brooks@neuro.uu.se
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Brooks
authors.forename: Owen G
authors.initials: OG
authors.lastname: O'Daly
authors.forename: Rudolf
authors.initials: R
authors.lastname: Uher
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Friederich
authors.forename: Vincent
authors.initials: V
authors.lastname: Giampietro
authors.forename: Michael
authors.initials: M
authors.lastname: Brammer
authors.forename: Steven C R
authors.initials: SC
authors.lastname: Williams
authors.forename: Helgi B
authors.initials: HB
authors.lastname: Schiöth
authors.forename: Janet
authors.initials: J
authors.lastname: Treasure
authors.forename: Iain C
authors.initials: IC
authors.lastname: Campbell
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology*; D001007:Anxiety / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D002032:Bulimia / Q000503:physiopathology*; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology; D005260:Female; D005502:Food; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D017072:Neostriatum / Q000187:drug effects / Q000503:physiopathology; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000187:drug effects / Q000503:physiopathology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D013850:Thinking / Q000502:physiology; D014793:Visual Cortex / Q000187:drug effects / Q000503:physiopathology; D055815:Young Adult
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors