title: Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: a randomised, multi-centre, controlled, double-blind study in 39 cats.
abstract: Chronic caudal stomatitis with alveolar/buccal mucositis in calicivirus-positive cats is the most severe presentation of feline chronic gingivostomatitis. Refractory cases are helped by antibiotic and anti-inflammatory treatments often including glucocorticoids. In order to evaluate the comparative efficacy of oromucosal administration of recombinant feline interferon omega (rFeIFN-ω) versus oral administration of glucocorticoids, a randomised, multi-centre, controlled, double-blind study was performed in 39 cats. The progression of behavioural, clinical and lesional scores was assessed over 90 days. Daily oromucosal treatment with 0.1 MU of rFeIFN-ω was associated with a significant improvement of clinical lesions (caudal stomatitis and alveolar/buccal mucositis) and a decrease of pain scores from D0 to D90. Although no such statistical improvement was noticed in the prednisolone group, there was, however, no significant difference between the two groups for most of the parameters, except pain at D60 and D90.
authors.affiliation: Clinique vétérinaire ADVETIA, Paris, France. hennet@advetia.fr
authors.forename: Philippe R
authors.initials: PR
authors.lastname: Hennet
authors.forename: Guy A L
authors.initials: GA
authors.lastname: Camy
authors.forename: David M
authors.initials: DM
authors.lastname: McGahie
authors.forename: Maxime V
authors.initials: MV
authors.lastname: Albouy
mesh_terms: D000284:Administration, Oral; D000818:Animals; D017250:Caliciviridae Infections / Q000150:complications / Q000188:drug therapy*; D017927:Calicivirus, Feline / Q000235:genetics / Q000302:isolation & purification; D002415:Cats; D004311:Double-Blind Method; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D007370:Interferon Type I / Q000592:standards / Q000627:therapeutic use*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D013280:Stomatitis / Q000188:drug therapy / Q000662:veterinary* / Q000821:virology; D014081:Tooth Extraction / Q000009:adverse effects / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007370:Interferon Type I; C063743:interferon omega 1; D011239:Prednisolone