title: Colorectal liver metastases.
abstract: BACKGROUND
  Despite major advances in therapies for liver metastases, colorectal cancer remains one of the commonest causes of cancer-related deaths in the UK.
  
  
  METHODS
  The international literature on the management of colorectal liver metastases (CLM) was reviewed.
  
  
  RESULTS
  Due to a combination of highly active systemic agents and low perioperative mortality achieved by high-volume centres, a growing number of patients are being offered liver resection with curative intent. Patients with bilobar and/or extrahepatic disease who would previously have received palliative treatment only, are undergoing major surgery with good results. This review focuses on preoperative evaluation, surgical planning and the role of adjuvant therapies in the management of patients with CLM.
  
  
  RESULTS
  Can ablative therapies match the outcomes of surgical resection? How can even more patients be rendered resectable?
  
  
  CONCLUSIONS
  The use of other therapies, such as radiofrequency ablation and selective internal radiation therapy.
  
  
  CONCLUSIONS
  New chemotherapy regimens for neo-adjuvant therapy and the development of new modalities of liver tumour ablation.
authors.affiliation: Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Sutcliffe
authors.forename: Satyajit
authors.initials: S
authors.lastname: Bhattacharya
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001918:Brachytherapy / Q000379:methods*; D017115:Catheter Ablation / Q000379:methods*; D002985:Clinical Protocols; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D006304:Health Status; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy; D020360:Neoadjuvant Therapy / Q000379:methods; D009367:Neoplasm Staging; D010347:Patient Care Planning / Q000592:standards; D011300:Preoperative Care / Q000379:methods / Q000592:standards; D012107:Research Design
chemical_list: D000970:Antineoplastic Agents