title: First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM.
abstract: Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol.
authors.affiliation: Department of Bacteriology, University Hospital of Dijon, BP 37013, 21070 Dijon Cedex, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Bador
authors.forename: Lucie
authors.initials: L
authors.lastname: Amoureux
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Duez
authors.forename: Anthony
authors.initials: A
authors.lastname: Drabowicz
authors.forename: Eliane
authors.initials: E
authors.lastname: Siebor
authors.forename: Catherine
authors.initials: C
authors.lastname: Llanes
authors.forename: Catherine
authors.initials: C
authors.lastname: Neuwirth
mesh_terms: D042441:Achromobacter denitrificans / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D001398:Aztreonam / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002511:Cephalosporins / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones / Q000494:pharmacology; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D009268:Nalidixic Acid / Q000494:pharmacology
chemical_list: D001398:Aztreonam; D001425:Bacterial Outer Membrane Proteins; D002511:Cephalosporins; D002701:Chloramphenicol; D024841:Fluoroquinolones; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009268:Nalidixic Acid