title: [The influence of N-, S-containing chinasolone derivatives (NC-224) on the biochemical and physicochemical parameters of membrane endoplasmatic reticulum and nuclear chromatine fractions of rats liver cells in conditions of its injury by tetrachloromethane].
abstract: Using biochemical and physicochemical methods of investigation in vivo, the effect of the substance NC-224, N-, S-chinasolone-derivative, on the lipoperoxidation activity in rat liver endoplasmatic reticulum membranes and nuclear chromatin fractions under tetrachloromethane intoxication have been studied. It was shown that NC-224 has pronounced antioxidant activity which is the biochemical basis of the substance membrane- and genome-protective effects and its ability to restore physicochemical properties of the surface and hydrophobic zones of hepatocyte membranes and structural parameter nuclear chromatin fractions in the conditions of chemical liver injury.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Gubs'kyî
authors.forename: G G
authors.initials: GG
authors.lastname: Goriushko
authors.forename: I F
authors.initials: IF
authors.lastname: Belenichev
authors.forename: S I
authors.initials: SI
authors.lastname: Kovalenko
authors.forename: N V
authors.initials: NV
authors.lastname: Litvinova
authors.forename: O M
authors.initials: OM
authors.lastname: Marchenko
authors.forename: T M
authors.initials: TM
authors.lastname: Kurapova
authors.forename: L P
authors.initials: LP
authors.lastname: Babenko
authors.forename: O M
authors.initials: OM
authors.lastname: Velychko
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000473:pathology; D002843:Chromatin / Q000187:drug effects* / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000032:analysis* / Q000737:chemistry; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D008315:Malondialdehyde / Q000032:analysis*; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D002843:Chromatin; D008055:Lipids; D002084:Butylated Hydroxytoluene; D008315:Malondialdehyde; D015125:Oxyquinoline; D002251:Carbon Tetrachloride