title: Comparison of single versus multiple courses of antenatal betamethasone in patients with threatened preterm labor.
abstract: OBJECTIVE
  To compare single versus multiple courses of antenatal betamethasone administration with regards to the morbidity and mortality of preterm neonates.
  
  
  METHODS
  One-hundred and twenty-two women with threatened preterm labor were allocated to three different betamethasone schedules: 1) two doses of betamethasone 12 mg, intramuscularly, 24 hours apart (standard treatment) (n = 41); 2) standard treatment plus a third dose of 12 mg after seven days (n = 41); and, 3) standard treatment plus one dose of 12 mg every seven days until delivery (n = 40). Neonatal morbidity and mortality as well as maternal morbidity were evaluated.
  
  
  RESULTS
  Neonatal parameters, such as frequency of respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, sepsis and neonatal mortality were not significantly different among the three groups for both singleton and multiple pregnancies. Similarly, maternal parameters were not significantly different among the three groups.
  
  
  CONCLUSIONS
  The administration of multiple betamethasone courses in threatened preterm labor is not superior to single courses with regards to neonatal morbidity and mortality, as well as to maternal morbidity.
authors.affiliation: First Department of Obstetrics and Gynaecology, "Papageorgiou" General Hospital, Aristotle University of Thessaloniki, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Bontis
authors.forename: D
authors.initials: D
authors.lastname: Vavilis
authors.forename: D
authors.initials: D
authors.lastname: Tsolakidis
authors.forename: D G
authors.initials: DG
authors.lastname: Goulis
authors.forename: P
authors.initials: P
authors.lastname: Tzevelekis
authors.forename: D
authors.initials: D
authors.lastname: Kellartzis
authors.forename: B C
authors.initials: BC
authors.lastname: Tarlatzis
mesh_terms: D001623:Betamethasone / Q000008:administration & dosage*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000517:prevention & control*; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D047928:Premature Birth; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D001623:Betamethasone