title: Short-term effects of soy protein diet in patients with proteinuric glomerulopathies.
abstract: BACKGROUND
  It has been suggested that soy protein can slow renal disease progression by decreasing plasma cholesterol and proteinuria in patients with nephropathies. This study was designed to evaluate the effect of soy protein on proteinuria and dyslipidemia, in patients with proteinuric glomerulopathies.
  
  
  METHODS
  Patients were divided into three groups: Control Group (n = 9) received diet with 0.8 g/kg/day of animal protein; Study Group 1 (n = 9), 0.8 g/kg/day of soy protein; and Group 2 (n = 9), 0.8 g/kg/day of soy protein plus fibers. The study period corresponded to eight weeks. During the baseline period and by the end of the study, patients were submitted to laboratorial and anthropometric evaluation.
  
  
  RESULTS
  There was no statistically significant difference between baseline and post-diet periods among the three groups in anthropometric parameters or body composition, neither in proteinuria levels (Control: 0.7 ± 0.6 versus 0.8 ± 0.6; Group 1: 2.0 ± 1.7 versus 1.9 ± 1.8; Group 2: 2.0 ± 1.4 versus 2.1 ± 2.0). However, a slight decrease in triglycerides (244.8 ± 275.9 versus 200.5 ± 34.0), total (234.0 ± 59.4 versus 181.2 ± 110.3) and LDL (136.0 ± 59.1 versus 104.1 ± 39.4) cholesterol in Group 1 was observed, although not significant.
  
  
  CONCLUSIONS
  We have not observed beneficial effects when using soy protein instead of animal protein with the aim of attenuating proteinuria and hyperlipidemia, but we have shown that soy protein has not caused deleterious changes in body composition, ensuring an adequate nutritional state.
authors.affiliation: Glomerulopathies Section, Division of Nephrology, Glomerulopathies Section, Department of Medicine, Universidade Federal de São Paulo.
authors.forename: Marion Souza
authors.initials: MS
authors.lastname: Ahmed
authors.forename: Alessandra C
authors.initials: AC
authors.lastname: Calabria
authors.forename: Gianna Mastroianni
authors.initials: GM
authors.lastname: Kirsztajn
mesh_terms: D000328:Adult; D004032:Diet; D005260:Female; D005921:Glomerulonephritis / Q000178:diet therapy*; D006801:Humans; D006949:Hyperlipidemias / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011507:Proteinuria / Q000178:diet therapy*; D030262:Soybean Proteins; D013997:Time Factors
chemical_list: D030262:Soybean Proteins