title: Surface plasmon resonance in monitoring of complement activation on biomaterials.
abstract: When artificial materials come into contact with blood, various biological responses are induced. For successful development of biomaterials used in biomedical devices that will be exposed to blood, understanding and control of these interactions are essential. Surface plasmon resonance (SPR) spectroscopy is one of the surface-sensitive optical methods to monitor biological interactions. SPR enables real-time and in situ analysis of interfacial events associated with biomaterials research. In this review, we describe an SPR biosensor and its application to monitor complement activation onto biomaterials surface. We also discuss the effect of surface properties of the material on complement activation.
authors.affiliation: Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606–8507, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Arima
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Toda
authors.forename: Hiroo
authors.initials: H
authors.lastname: Iwata
mesh_terms: D001672:Biocompatible Materials / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D003167:Complement Activation / Q000187:drug effects* / Q000276:immunology / Q000502:physiology*; D016903:Drug Monitoring / Q000295:instrumentation / Q000379:methods; D006801:Humans; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials