title: CAM-CM: a signal deconvolution tool for in vivo dynamic contrast-enhanced imaging of complex tissues.
abstract: CONCLUSIONS
  In vivo dynamic contrast-enhanced imaging tools provide non-invasive methods for analyzing various functional changes associated with disease initiation, progression and responses to therapy. The quantitative application of these tools has been hindered by its inability to accurately resolve and characterize targeted tissues due to spatially mixed tissue heterogeneity. Convex Analysis of Mixtures - Compartment Modeling (CAM-CM) signal deconvolution tool has been developed to automatically identify pure-volume pixels located at the corners of the clustered pixel time series scatter simplex and subsequently estimate tissue-specific pharmacokinetic parameters. CAM-CM can dissect complex tissues into regions with differential tracer kinetics at pixel-wise resolution and provide a systems biology tool for defining imaging signatures predictive of phenotypes.
  
  
  BACKGROUND
  The MATLAB source code can be downloaded at the authors' website www.cbil.ece.vt.edu/software.htm
  
  
  BACKGROUND
  yuewang@vt.edu
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Tsung-Han
authors.initials: TH
authors.lastname: Chan
authors.forename: Peter L
authors.initials: PL
authors.lastname: Choyke
authors.forename: Elizabeth M C
authors.initials: EM
authors.lastname: Hillman
authors.forename: Chong-Yung
authors.initials: CY
authors.lastname: Chi
authors.forename: Zaver M
authors.initials: ZM
authors.lastname: Bhujwalla
authors.forename: Ge
authors.initials: G
authors.lastname: Wang
authors.forename: Sean S
authors.initials: SS
authors.lastname: Wang
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Szabo
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D003952:Diagnostic Imaging / Q000379:methods*; D008954:Models, Biological; D012984:Software; D049490:Systems Biology / Q000379:methods