title: Serum vaspin levels in hypothyroid patients.
abstract: OBJECTIVE
  To elucidate the link between TSH and obesity, the relationship between TSH and adipocytokines were previously studied. Animal studies demonstrated a possible relationship between vaspin levels and thyroid functions. In this study, we aimed to investigate vaspin levels in hypothyroid states and its relationship with insulin resistance parameters in humans.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  We enrolled 27 overt hypothyroid, 33 subclinical hypothyroid and 41 euthyroid patients. We measured the body mass index (BMI), fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), lipid profile, TSH, free triiodothyronine, free thyroxine and vaspin levels. The change in vaspin levels in 12 overt hypothyroid patients after establishment of euthyroidism was analysed.
  
  
  RESULTS
  All groups were age-matched. Overt hypothyroid group had higher BMI values (P<0.05) than other groups. No significant difference was observed in insulin levels and HOMA-IR among the groups (P>0.05). Adjusted vaspin levels for BMI and age were similar among the groups. Mean vaspin levels in overt, subclinical and euthyroid patients were 1.20 ± 1.17, 1.48 ± 0.93 and 0.95 ± 0.75  ng/ml respectively (P>0.05). There was no significant association between vaspin levels and BMI, fasting glucose, insulin and HOMA-IR (P>0.05). Establishing euthyroidism in hypothyroid patients did not result in a significant change in vaspin levels (before and after treatment, 1.35 ± 1.06 and 1.25 ± 0.68  ng/ml, respectively; P>0.05).
  
  
  CONCLUSIONS
  We herein present novel data indicating vaspin levels are neither altered in overt and subclinical hypothyroidism nor have a relationship with features of insulin resistance in hypothyroid patients.
authors.affiliation: Department of Endocrinology and Metabolism, Hacettepe University Medical School, Sihhiye, Ankara, Turkey.
authors.forename: Neşe
authors.initials: N
authors.lastname: Cinar
authors.forename: Neşe Ersöz
authors.initials: NE
authors.lastname: Gülçelik
authors.forename: Kadriye
authors.initials: K
authors.lastname: Aydín
authors.forename: Safak
authors.initials: S
authors.lastname: Akín
authors.forename: Aydan
authors.initials: A
authors.lastname: Usman
authors.forename: Alper
authors.initials: A
authors.lastname: Gürlek
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015843:Serpins / Q000097:blood*; D012727:Sex Characteristics; D013972:Thyrotropin / Q000097:blood; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D007328:Insulin; D008055:Lipids; C507339:SERPINA12 protein, human; D015843:Serpins; D013972:Thyrotropin