title: Advent of complex flows in epithelial tissues.
abstract: The collective migration of cells in tissue pervades many important biological processes, such as wound healing, organism development, and cancer metastasis. Recent experiments on wound healing show that the collective migratory behavior of cells can be quite complex, including transient vortices and long-range correlations. Here, we explore cellular flows in epithelial tissues using a model that considers the force distribution and polarity of a single cell along with cell-cell adhesion. We show that the dipole nature of a crawling cell's force distribution destabilizes steady cellular motion. We determine the values of the physical parameters that are necessary to produce these complex motions and use numerical simulation to verify the linear analysis and to demonstrate the complex flows. We find that the tendency for cells to align is the dominant physical parameter that determines the stability of steady flows in the epithelium.
authors.affiliation: Department of Cell Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut 06030-6406, USA.
authors.forename: Pilhwa
authors.initials: P
authors.lastname: Lee
authors.forename: Charles
authors.initials: C
authors.lastname: Wolgemuth
mesh_terms: D002448:Cell Adhesion; D002465:Cell Movement; D004847:Epithelial Cells / Q000166:cytology* / Q000473:pathology; D008954:Models, Biological; D014945:Wound Healing