title: Effect of A-HRS on blood pressure and metabolic alterations in fructose-induced hypertensive rats.
abstract: Fructose feeding induces a rise in blood pressure in normal rats that is associated with insulin resistance, hyperinsulinemia, hyperglycaemia, hypercholesterolaemia and hypertriglyceridaemia. We have examined the effect of chronic administration of A-HRS (100 and 300 mg kg⁻¹; p.o.) isolated from Hibiscus rosa sinensis (Malvaceae) on systolic blood pressure (SBP), vascular reactivity, serum glucose, triglycerides, cholesterol, uric acid and insulin in fructose-induced hypertension model. A-HRS treatment (100 and 300 mg kg⁻¹, p.o. for 6 weeks) reduced SBP, vascular reactivity changes to catecholamines and reversed the metabolic alterations induced by fructose (10%) treatment for 6 weeks. The cumulative concentration response curve (CCRC) of angiotensin II (Ang II) was shifted towards the right in rats treated with A-HRS using an isolated strip of ascending colon. The results suggest that A-HRS could prevent the development of high-blood pressure induced by a diet rich in fructose, probably by reversing the metabolic alterations induced by fructose. In conclusion, A-HRS has an antihypertensive action in a fructose model.
authors.affiliation: Department of Pharmacology, M.G.V's Pharmacy College, Panchavati, Nasik 422003, Maharashtra, India. mm_nasik@yahoo.co.in
authors.forename: Mahalaxmi
authors.initials: M
authors.lastname: Mohan
authors.forename: Bhagyashree
authors.initials: B
authors.lastname: Khade
authors.forename: Amol
authors.initials: A
authors.lastname: Shinde
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D004353:Drug Evaluation, Preclinical; D005632:Fructose; D031584:Hibiscus / Q000737:chemistry*; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts; D014280:Triglycerides; D014527:Uric Acid; D005632:Fructose; D002784:Cholesterol