title: Metathesis access to monocyclic iminocyclitol-based therapeutic agents.
abstract: By focusing on recent developments on natural and non-natural azasugars (iminocyclitols), this review bolsters the case for the role of olefin metathesis reactions (RCM, CM) as key transformations in the multistep syntheses of pyrrolidine-, piperidine- and azepane-based iminocyclitols, as important therapeutic agents against a range of common diseases and as tools for studying metabolic disorders. Considerable improvements brought about by introduction of one or more metathesis steps are outlined, with emphasis on the exquisite steric control and atom-economical outcome of the overall process. The comparative performance of several established metathesis catalysts is also highlighted.
authors.affiliation: Institute of Organic Chemistry, Romanian Academy, 202B Spl. Independentei, P.O. Box 35-108, Bucharest 060023, Romania.
authors.forename: Ileana
authors.initials: I
authors.lastname: Dragutan
authors.forename: Valerian
authors.initials: V
authors.lastname: Dragutan
authors.forename: Carmen
authors.initials: C
authors.lastname: Mitan
authors.forename: Hermanus Cm
authors.initials: HC
authors.lastname: Vosloo
authors.forename: Lionel
authors.initials: L
authors.lastname: Delaude
authors.forename: Albert
authors.initials: A
authors.lastname: Demonceau