title: Optimizing and evaluating the biocompatibility of fiber composites with calcium phosphate additives.
abstract: Composite materials based on a polyamide fabric (aramid) and a polydymethylsiloxane (PDMS) matrix were designed for application in bone surgery. In order to increase the bioactivity, 2, 5, 10, 15, 20, and 25 vol.% of nano/micro hydroxyapatite (HA) and tricalcium phosphate (TCP) were added. We studied the effect of the additives on the biocompatibility of the composite. It appears that nano additives have a more favorable effect on mechanical properties than microparticles. 15 vol.% of nano hydroxyapatite additive is an optimum amount for final application of the composites as substitutes for bone tissue: in this case both the mechanical properties and the biological properties are optimized without distinct changes in the inner structure of the composite.
authors.affiliation: Laboratory of Biomechanics, Department of Mechanics, Biomechanics and Mechatronics, Czech Technical University in Prague, Czech Republic. tomas.suchy@fs.cvut.cz
authors.forename: Tomáš
authors.initials: T
authors.lastname: Suchý
authors.forename: Karel
authors.initials: K
authors.lastname: Balík
authors.forename: Zbyněk
authors.initials: Z
authors.lastname: Sucharda
authors.forename: Miroslav
authors.initials: M
authors.lastname: Sochor
authors.forename: Monika
authors.initials: M
authors.lastname: Lapčíková
authors.forename: Radek
authors.initials: R
authors.lastname: Sedláček
mesh_terms: D000818:Animals; D001031:Apatites; D018786:Bone Substitutes / Q000737:chemistry* / Q000592:standards*; D001842:Bone and Bones / Q000601:surgery*; D002130:Calcium Phosphates; D004129:Dimethylpolysiloxanes; D017886:Durapatite; D004548:Elasticity; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D055616:Microtechnology; D049329:Nanostructures; D009757:Nylons; D016348:Osseointegration / Q000502:physiology; D010949:Plasma; D011108:Polymers; D011817:Rabbits; D012984:Software; D013499:Surface Properties
chemical_list: D001031:Apatites; D018786:Bone Substitutes; D002130:Calcium Phosphates; D004129:Dimethylpolysiloxanes; C039578:Kevlar Aramid fibers; D009757:Nylons; D011108:Polymers; C085707:poly(dimethylsiloxane)-polyamide copolymer; D017886:Durapatite; C018392:tricalcium phosphate