title: Ovarian steroid cell tumor, not otherwise specified (NOS): an unusual case with myelolipoma.
abstract: Myelolipoma is an uncommon lesion composed of mature fat and hematopoietic cells. Extra-adrenal myelolipoma is rare. We report an unusual case of concurrent myelolipoma in a steroid cell tumor in a 21-year-old woman with virilization. She had a 6-year secondary amenorrhea history. Her serum testosterone level was elevated (16.2-24.9 nmol/L). Transvaginal ultrasound and computed tomography showed a solid round pelvic mass. The left ovarian mass was grossly well encapsulated with a tan-to-dark-brown, vaguely nodular cut surface. Microscopically, the tumor was characterized by large aggregates of cells resembling typical hormone-secreting cells and the stroma was composed of mature fat and rich hematopoietic cells representing all 3 hematopoietic cell lineages. Immunohistochemistry showed that the tumor cells were strongly positive for α-inhibin and Melan-A. Lineage-specific markers including myeloid peroxidase were variably expressed in hematopoietic cells. This rare case will expand our appreciation of the spectrum and histogenesis of ovarian tumors.
authors.affiliation: Department of Surgical Pathology, Women's Reproductive Health Laboratory of Zhejiang Province, The Affiliated Women's Hospital, School of Medicine, Zhejiang University, 2 Xueshi Road, Hangzhou, Zhejiang, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhang
authors.forename: Bingjian
authors.initials: B
authors.lastname: Lü
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018209:Myelolipoma / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D018312:Sex Cord-Gonadal Stromal Tumors / Q000473:pathology*; D055815:Young Adult