title: Lifespan attention deficit/hyperactivity disorder and borderline personality disorder symptoms in female patients: a latent class approach.
abstract: Attention-deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD) are frequently comorbid. To contribute to a better understanding of the associations regularly found between ADHD and BPD, on the one hand, and the developmental pathways for these disorders, on the other hand, latent class analyses (LCA) were undertaken to identify classes differing in profiles of childhood symptoms of ADHD and adult symptoms of ADHD and BPD. Diagnostic interviews with 103 female outpatients meeting the criteria for ADHD and/or BPD were used to assess current DSM-IV symptoms; childhood symptoms of ADHD were assessed in parent interviews. The latent classes were examined in relation to the DSM-IV conceptualizations of ADHD and BPD. And relations between childhood and adult classes were examined to hypothesize about developmental trajectories. LCA revealed an optimal solution with four distinct symptom profiles: only ADHD symptoms; BPD symptoms and only ADHD symptoms of hyperactivity; BPD symptoms and ADHD symptoms of inattention and hyperactivity; BPD symptoms and ADHD symptoms of inattention, hyperactivity and impulsivity. All patients with BPD had some ADHD symptoms in both adulthood and childhood. Hyperactivity was least discriminative of adult classes. Adult hyperactivity was not always preceded by childhood hyperactivity; some cases of comorbid ADHD and BPD symptoms were not preceded by significant childhood ADHD symptoms; and some cases of predominantly BPD symptoms could be traced back to combined symptoms of ADHD in childhood. The results underline the importance of taking ADHD diagnoses into account with BPD. ADHD classification subtypes may not be permanent over time, and different developmental pathways to adult ADHD and BPD should therefore be investigated.
authors.affiliation: Department of Psychiatry, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands. f.vandijk@psy.umcn.nl
authors.forename: Fiona
authors.initials: F
authors.lastname: van Dijk
authors.forename: Martijn
authors.initials: M
authors.lastname: Lappenschaar
authors.forename: Cornelis
authors.initials: C
authors.lastname: Kan
authors.forename: Robbert-Jan
authors.initials: RJ
authors.lastname: Verkes
authors.forename: Jan
authors.initials: J
authors.lastname: Buitelaar
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000145:classification* / Q000453:epidemiology*; D001883:Borderline Personality Disorder / Q000145:classification* / Q000453:epidemiology*; D002648:Child; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
chemical_list: D057126:Nuclear Receptor Subfamily 4, Group A, Member 2