title: Preparation and in vitro anticancer activity of oxymatrine mixed micellar nanoparticles.
abstract: The aim of this study was to prepare oxymatrine (OMT) mixed micellar nanoparticles to delay release of the drug and enhance its cytotoxicity against cancer cells. A co-solvent evaporation method using lipoid E80, lipoid S75, MPEG-PLA and Poloxamer 188 was chosen to prepare the OMT formulation, and its release characteristics, cytotoxic activity in vitro and physical characteristics were evaluated. The results showed that OMT mixed micellar nanoparticles have sustained release and cytotoxic activity in vitro to the SMMC-7721 cell line.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, PR China.
authors.forename: Nan
authors.initials: N
authors.lastname: Jin
authors.forename: Yong-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Deng
authors.forename: Qian
authors.initials: Q
authors.lastname: Sun
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D002138:Calibration; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding; D005079:Excipients; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D008823:Micelles; D053758:Nanoparticles; D020442:Poloxamer; D011091:Polyesters; D011092:Polyethylene Glycols; D011807:Quinolizines / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D012015:Reference Standards; D015203:Reproducibility of Results; D012995:Solubility; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D005079:Excipients; D007202:Indicators and Reagents; D008823:Micelles; D020442:Poloxamer; D011091:Polyesters; D011092:Polyethylene Glycols; D011807:Quinolizines; C492425:methoxy poly(ethylene glycol)-poly(lactide); C037573:oxymatrine; D000093842:Matrines