title: Synthesis, antiviral and cytotoxic investigation of 2-phenyl-3-substituted quinazolin-4(3H)-ones.
abstract: OBJECTIVE
  A series of 3(benzylideneamino)-2-phenyl quinazoline-4(3H)-ones was synthesized by reaction of 3-amino-2-phenyl-3H-quinazoline-4-one with various carbonyl compounds.
  
  
  METHODS
  Chemical structures of the synthesized compounds were confirmed by IR, 1H-NMR and mass spectral analysis. Title compounds were investigated for cytotoxicity and antiviral activity against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK-KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1 N1 subtype, influenza A H3N2 subtype, influenza B and vesicular stomatitis virus.
  
  
  CONCLUSIONS
  Compound 3d was found inhibit viral replication of para influenza-3virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus in Vero cell cultures.
authors.affiliation: Medicinal Chemistry Research Laboratory, KMCH College of Pharmacy, Coimbatore, India. pharmsuki@gmail.com
authors.forename: S K
authors.initials: SK
authors.lastname: Krishnan
authors.forename: S
authors.initials: S
authors.lastname: Ganguly
authors.forename: R
authors.initials: R
authors.lastname: Veerasamy
authors.forename: B
authors.initials: B
authors.lastname: Jan
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D002415:Cats; D002460:Cell Line; D002522:Chlorocebus aethiops; D004285:Dogs; D006367:HeLa Cells; D006801:Humans; D052999:Quinazolinones / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D014709:Vero Cells; D014777:Virus Diseases / Q000188:drug therapy* / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D052999:Quinazolinones