title: Association between plasma monocyte chemoattractant protein-1 levels and the extent of atherosclerotic peripheral artery disease.
abstract: Peripheral artery disease occurs at advanced ages and accounts for substantial cardiovascular morbidity and mortality. Monocyte chemoattractant protein-1 (MCP-1), a member of the cysteine-cysteine family of chemokines, is one of the cytokines involved in the pathogenesis of atherosclerosis and is also known as cysteine-cysteine chemokine ligand 2 (CCL2). The aim of the current study was to investigate the association between the extent of atherosclerotic peripheral artery disease (PAD) and the increase in MCP-1 level. Eighty consecutive patients who had undergone peripheral angiography for suspected PAD were included. Of these patients, 48 (60%) had hypertension, 23 (28.8%) had type 2 diabetes mellitus, 39 (48.8%) had a family history of coronary artery disease, 23 (28.8%) were cigarette smokers, and 42 (52.5%) had hypercholesterolemia. Angiography revealed that the peripheral arteries of the lower extremity were normal in 41 (51.3%) patients, whereas 39 (48.7%) patients had varying degrees of PAD. The patients were queried regarding age, gender, and atherosclerotic risk factors. The plasma MCP-1 levels were significantly lower in the patients without PAD than those in the patients with PAD (172.27 ± 38.05 pg/mL vs. 200.87 ± 39.31 pg/mL, p = 0.001). Moreover, as the severity of PAD increases, MCP-1 levels also increase. Thus, the plasma MCP-1 level can be used in the diagnosis of PAD and in determining the extent of atherosclerotic PAD of the lower extremities, as in determining the extent of coronary artery disease.
authors.affiliation: Department of Cardiology, Rize University Faculty of Medicine, Rize, Turkey. omersatiroglu@yahoo.com
authors.forename: Omer
authors.initials: O
authors.lastname: Satiroglu
authors.forename: Huseyin Avni
authors.initials: HA
authors.lastname: Uydu
authors.forename: Adem
authors.initials: A
authors.lastname: Demir
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bostan
authors.forename: Mehtap
authors.initials: M
authors.lastname: Atak
authors.forename: Engin
authors.initials: E
authors.lastname: Bozkurt
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology*; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000473:pathology*; D012307:Risk Factors
chemical_list: D018932:Chemokine CCL2