title: Rebound acid hypersecretion after withdrawal of gastric acid suppressing drugs: new evidence of similitude.
abstract: BACKGROUND
  Homeopathy is based on the principle of similitude (similia similibus curentur) using medicines that cause effects similar to the symptoms of disease in order to stimulate the reaction of the organism. Such vital, homeostatic or paradoxical reaction of the organism is closely related to rebound effect of drugs.
  
  
  METHODS
  Review of the literature concerning the rebound effects of drugs used to suppress gastric acidity, particularly proton pump inhibitors (PPIs).
  
  
  RESULTS
  The mechanism of action of these effects is discussed. Rebound in terms of clinical symptoms and physiological effects occur in about 40% of people taking PPIs, their timing depends on the half-life of the drug and the adaptation period of the physiological mechanisms involved. The wide use of PPIs may be linked to the rising incidence of carcinoid tumours.
  
  
  CONCLUSIONS
  These findings support Hahnemann's concept of secondary action of drugs. We are developing a homeopathic materia medica and repertory of modern drugs on the basis of reported rebound effects.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. marcus@homeozulian.med.br
authors.forename: Marcus Zulian
authors.initials: MZ
authors.lastname: Teixeira
mesh_terms: D004305:Dose-Response Relationship, Drug; D019317:Evidence-Based Medicine; D005744:Gastric Acid / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000517:prevention & control*; D006705:Homeopathy / Q000379:methods*; D006801:Humans; D008419:Materia Medica / Q000627:therapeutic use*; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000517:prevention & control*
chemical_list: D008419:Materia Medica; D054328:Proton Pump Inhibitors