title: Cytotoxicity testing of carrier-based microcomposites for DPI application.
abstract: Inhalation is an attractive delivery route for systemic and local therapy. High local drug concentrations may permit non-invasive delivery, lower therapeutic doses, reduced systemic side-effects, and reduced metabolic degradation of the drug in the liver. In our earlier study, carrier-based microcomposites were prepared and investigated. The present study introduces studies of the cytotoxicity of meloxicam-containing microcomposites on monolayers of Calu-3 cells, in order to acquire information on its availability in pulmonary formulations. By relating cytotoxicity and drug dissolution, the appropriate amount of meloxicam for dry powder inhalation could be determined.
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Hungary.
authors.forename: R
authors.initials: R
authors.lastname: Ambrus
authors.forename: A
authors.initials: A
authors.lastname: Pomázi
authors.forename: K
authors.initials: K
authors.lastname: Réti-Nagy
authors.forename: F
authors.initials: F
authors.lastname: Fenyvesi
authors.forename: M
authors.initials: M
authors.lastname: Vecsernyés
authors.forename: P
authors.initials: P
authors.lastname: Szabó-Révész
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D016503:Drug Delivery Systems; D058995:Dry Powder Inhalers; D006801:Humans; D000077239:Meloxicam; D011136:Polysorbates; D011205:Povidone; D013535:Suspensions; D013843:Thiazines / Q000008:administration & dosage / Q000633:toxicity*; D013844:Thiazoles / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011136:Polysorbates; D013535:Suspensions; D013843:Thiazines; D013844:Thiazoles; D011205:Povidone; D000077239:Meloxicam