title: Recent developments in the field of oxa-Michael reactions.
abstract: Oxa-Michael reactions, i.e. addition reactions of oxygen nucleophiles to conjugated systems, have traditionally received much less attention from the scientific community compared to the addition of carbon nucleophiles to conjugate acceptor systems (Michael reaction). This was mainly due to lack of reactivity and selectivity of these reactions. Within the last few years however, there has been a remarkable increase in publications focussing on method development as well as applications to natural product synthesis. This tutorial review discusses instructive examples that have substantially broadened the scope of oxa-Michael reactions.
authors.affiliation: Bayer Pharma AG, Aprather Weg 18a, D-42113 Wuppertal, Germany. carlfriedrich.nising@bayer.com
authors.forename: Carl F
authors.initials: CF
authors.lastname: Nising
authors.forename: Stefan
authors.initials: S
authors.lastname: Bräse
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001688:Biological Products; D006571:Heterocyclic Compounds; D004364:Pharmaceutical Preparations; D010100:Oxygen