title: Use of multimode optical fibers for fiber-based coherent anti-Stokes Raman scattering microendoscopy imaging.
abstract: A multimode fiber (MMF) was used for both delivery of excitation lasers and collection of returned coherent anti-Stokes Raman scattering (CARS) signals in a CARS microendoscopy prototype imaging system. We demonstrated a polarization-based scheme for suppression of four-wave mixing (FWM) signals in delivery fibers. Our experimental results showed that this polarization-based FWM-suppressing scheme can dramatically reduce FWM signals generated in MMFs, and MMFs can be used to produce CARS images in this microendoscopy system. The proposed MMF-based CARS microendoscopy imaging system with the polarization-based FWM-suppressing scheme offers a potential platform for building fiber-based CARS microendoscopes that can effectively suppress FWM background noises.
authors.affiliation: Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, Texas 77030, USA. Zhwang@ieee.org
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Gao
authors.forename: Yuanxin
authors.initials: Y
authors.lastname: Chen
authors.forename: Pengfei
authors.initials: P
authors.lastname: Luo
authors.forename: Kelvin K
authors.initials: KK
authors.lastname: Wong
authors.forename: Stephen T C
authors.initials: ST
authors.lastname: Wong
mesh_terms: D004724:Endoscopy / Q000295:instrumentation*; D055100:Optical Fibers; D013059:Spectrum Analysis, Raman / Q000295:instrumentation*