title: The effect of aging and an ovariectomy operation on the level of phosphorylated CaM kinase II in the hippocampus of female mice prenatally exposed to diethylstilbestrol.
abstract: The effects of aging and an ovariectomy operation on the brain-disrupting actions caused by prenatal exposure to diethylstilbestrol (DES) were studied in mice. In the young DES-exposed female mice, the level of hippocampal phosphorylated CaM kinase II (pCaMKII) was not changed. However, at 8 months, the level of hippocampal pCaMKII in the DES-exposed female mice significantly increased compared to control. Moreover, the ovariectomy significantly increased the level of pCaMKII in the hippocampus but not the cortex of DES-exposed female mice. These findings suggest that the influence of prenatally-exposed DES on the hippocampal pCaMKII may be affected by the endogenous female sex hormones such as estrogen.
authors.affiliation: Department of Environmental and Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Soeda
authors.forename: Masako
authors.initials: M
authors.lastname: Nagata
authors.forename: Taku
authors.initials: T
authors.lastname: Kaitsuka
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shirasaki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takahama
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D015153:Blotting, Western; D001923:Brain Chemistry / Q000187:drug effects; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D002273:Carcinogens / Q000633:toxicity*; D004054:Diethylstilbestrol / Q000633:toxicity*; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D010052:Ovariectomy; D010766:Phosphorylation; D017397:Prefrontal Cortex / Q000187:drug effects / Q000201:enzymology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D002273:Carcinogens; D004054:Diethylstilbestrol; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2