title: Role of aquaporins in cell migration and edema formation in human brain tumors.
abstract: The aquaporins (AQPs) are a family of transmembrane water channel proteins widely distributed and play a major role in transcellular and transepithelial water movement. Moreover, recent evidence indicates that AQPs may be involved in cell migration, angiogenesis, and tumor growth. This review article summarizes literature data concerning the involvement of AQP-1 and -4 in human brain tumor growth and edema formation and suggests a potential therapeutic approach by antagonizing their biological activity.
authors.affiliation: Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Nico
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D051398:Aquaporin 1 / Q000378:metabolism*; D051401:Aquaporin 4 / Q000378:metabolism*; D001929:Brain Edema / Q000378:metabolism* / Q000473:pathology*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology*; D002465:Cell Movement; D006801:Humans
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D051398:Aquaporin 1