title: Network single-walled carbon nanotube biosensors for fast and highly sensitive detection of proteins.
abstract: Detection of proteins is powerfully assayed in the diagnosis of diseases. A strategy for the development of an ultrahigh sensitivity biosensor based on a network single-walled carbon nanotube (SWNT) field-effect transistor (FET) has been demonstrated. Metallic SWNTs (m-SWNTs) in the network nanotube FET were selectively removed or cut via a carefully controlled procedure of electrical break-down (BD), and left non-conducting m-SWNTs which magnified the Schottky barrier (SB) area. This nanotube FET exhibited ultrahigh sensitivity and fast response to biomolecules. The lowest detection limit of 0.5 pM was achieved by exploiting streptavidin (SA) or a biotin/SA pair as the research model, and BD-treated nanotube biosensors had a 2 × 10(4)-fold lower minimum detectable concentration than the device without BD treatment. The response time is in the range of 0.3-3 min.
authors.affiliation: Research Centre for Micro/Nanotechnology, Harbin Institute of Technology, No. 2 YiKuang Street, Harbin 150080, People's Republic of China. hupa@hit.edu.cn
authors.forename: Pingán
authors.initials: P
authors.lastname: Hu
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Wen
authors.forename: Can
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D001710:Biotin / Q000032:analysis; D002417:Cattle; D004553:Electric Conductivity; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D011506:Proteins / Q000032:analysis*; D019809:Streptavidin / Q000032:analysis; D013997:Time Factors
chemical_list: D037742:Nanotubes, Carbon; D011506:Proteins; D001710:Biotin; D019809:Streptavidin