title: Official Positions for FRAX® clinical regarding biochemical markers from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®.
abstract: The best indirect evidence that increased bone turnover contributes to fracture risk is the fact that most of the proven therapies for osteoporosis are inhibitors of bone turnover. The evidence base that we can use biochemical markers of bone turnover in the assessment of fracture risk is somewhat less convincing. This relates to natural variability in the markers, problems with the assays, disparity in the statistical analyses of relevant studies and the independence of their contribution to fracture risk. More research is clearly required to address these deficiencies before biochemical markers might contribute a useful independent risk factor for inclusion in FRAX(®).
authors.affiliation: Academic Unit of Bone Metabolism, University of Sheffield, Sheffield S5 7AU, UK. e.v.mccloskey@shef.ac.uk
authors.forename: Eugene V
authors.initials: EV
authors.lastname: McCloskey
authors.forename: Samuel
authors.initials: S
authors.lastname: Vasikaran
authors.forename: Cyrus
authors.initials: C
authors.lastname: Cooper
mesh_terms: D015502:Absorptiometry, Photon; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D016723:Bone Remodeling; D003936:Diagnosis, Computer-Assisted; D005272:Femur Neck / Q000000981:diagnostic imaging; D050723:Fractures, Bone / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D010024:Osteoporosis / Q000175:diagnosis; D058866:Osteoporotic Fractures / Q000175:diagnosis; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D015415:Biomarkers