title: Cdc48/p97, a key actor in the interplay between autophagy and ubiquitin/proteasome catabolic pathways.
abstract: The AAA-ATPase Cdc48/p97 controls a large array of cellular functions including protein degradation, cell division, membrane fusion through its ability to interact with and control the fate of ubiquitylated proteins. More recently, Cdc48/p97 also appeared to be involved in autophagy, a catabolic cell response that has long been viewed as completely distinct from the Ubiquitine/Proteasome System. In particular, conjugation by ubiquitin or ubiquitin-like proteins as well as ubiquitin binding proteins such as Cdc48/p97 and its cofactors can target degradation by both catabolic pathways. This review will focus on the recently described functions of Cdc48/p97 in autophagosome biogenesis as well as selective autophagy.
authors.affiliation: CNRS, UMR7592, Institut Jacques Monod, Univ Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Dargemont
authors.forename: Batool
authors.initials: B
authors.lastname: Ossareh-Nazari
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001343:Autophagy; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D012270:Ribosomes / Q000378:metabolism; D057149:Ubiquitinated Proteins / Q000378:metabolism*; D000074405:Valosin Containing Protein
chemical_list: D018797:Cell Cycle Proteins; D057149:Ubiquitinated Proteins; D046988:Proteasome Endopeptidase Complex; D000251:Adenosine Triphosphatases; D000074405:Valosin Containing Protein