title: Free radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models.
abstract: OBJECTIVE
  To determine the in vitro free radical scavenging property and in vivo diuretic effect of Triglize™ , a marketed polyherbal formulation in experimental models.
  
  
  METHODS
  The aqueous extract of polyherbal formulation (PHF) triglize was used for the experiment. The free radical scavenging property and antioxidant effect of PHF were studied by LPS-induced free radicals in rat macrophages cells and DPPH (2, 2-Diphenyl-1-Picrylhydrazyl) methods, respectively. The diuretic effect of a PHF was studied with Lipschitz model using male Wistar rats.
  
  
  RESULTS
  PHF significantly inhibited lipopolysaccharide -induced free radicals in rat macrophages and it showed moderate antioxidant potential in DPPH model. Polyherbal formulation at 50, 200 and 400 mg/ kg significantly increased potassium excretion in urine at 0-5 h and 5-24 h. The diuretic effect of PHF was as similar as furosemide.
  
  
  CONCLUSIONS
  The PHF has significant diuretic effect and free radical scavenging properties.
authors.affiliation: Department of Pharmacology, JIPMER, Pondicherry, India.
authors.forename: S
authors.initials: S
authors.lastname: Parasuraman
authors.forename: Ep
authors.initials: E
authors.lastname: Kumar
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Sf
authors.initials: S
authors.lastname: Emerson