title: Antifungal susceptibility of Candida albicans in biofilms.
abstract: Candida albicans are the most common fungi associated with biofilm-related infections. Biofilms are defined as microbial communities encased in a matrix of extracellular polymeric substances. The most important feature of biofilm growth is the high resistance to antimicrobial agents that can be up to 1000-fold greater than that of planktonic cells. This review discusses the factors affecting antifungal resistance as well as activity of mono- and combination therapy of different antifungal classes and antifungal activity in vitro and in vivo against C. albicans biofilms.
authors.affiliation: Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
authors.forename: Selma
authors.initials: S
authors.lastname: Tobudic
authors.forename: Christina
authors.initials: C
authors.lastname: Kratzer
authors.forename: Andrea
authors.initials: A
authors.lastname: Lassnigg
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Presterl
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects* / Q000502:physiology; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans
chemical_list: D000935:Antifungal Agents