title: [Infliximab in ankylosing spondylitis associated with chronic hepatitis B infection. Role of Lamivudine therapy].
abstract: Anti-tumor necrosis factor-a (TNF) therapy has been associated with reactivation of hepatitis B virus infection. Case reports have suggested the concomitant need of lamivudine treatment in patients with HBV infection treated with antiTNFa agents. We describe a case of ankylosing spondylitis with positive HBV surface antigen (HBsAg) treated with infliximab and lamivudine. Clinical response was excellent but when lamivudine therapy was stopped, reactivation of replication viral occurred. After the reintroduction of lamivudine, viral replication was controlled and liver function tests were normalized. Preventive long-term lamivudine therapy is mandatory when anti-TNFa therapy is maintained in patients with chronic HBV infection.
authors.affiliation: Servicio de Reumatología. Hospital Universitario Puerta de Hierro. Madrid. España.
authors.forename: Jesús
authors.initials: J
authors.lastname: Sanz Sanz
authors.forename: Lucía
authors.initials: L
authors.lastname: Silva Fernández
authors.forename: José Luis
authors.initials: JL
authors.lastname: Calleja Panero
authors.forename: Mónica
authors.initials: M
authors.lastname: Fernández-Castro
authors.forename: José Luis
authors.initials: JL
authors.lastname: Andreu Sánchez