title: Synthesis and anti-platelet activity of obovatol derivatives.
abstract: Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.
authors.affiliation: College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 361-763, Korea.
authors.forename: Jae-Hwan
authors.initials: JH
authors.lastname: Kwak
authors.forename: Seul
authors.initials: S
authors.lastname: Lee
authors.forename: Eun-Seok
authors.initials: ES
authors.lastname: Park
authors.forename: Jin-Kyung
authors.initials: JK
authors.lastname: In
authors.forename: Jiho
authors.initials: J
authors.lastname: Song
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Nam Song
authors.initials: NS
authors.lastname: Choi
authors.forename: Heesoon
authors.initials: H
authors.lastname: Lee
authors.forename: Yeo-Pyo
authors.initials: YP
authors.lastname: Yun
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.forename: Young-Shin
authors.initials: YS
authors.lastname: Kwak
authors.forename: Kyung Hoon
authors.initials: KH
authors.lastname: Min
authors.forename: Jae-Kyung
authors.initials: JK
authors.lastname: Jung
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D010647:Phenyl Ethers / Q000737:chemistry / Q000494:pharmacology*; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D000438:Alcohols; D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D010647:Phenyl Ethers; D010975:Platelet Aggregation Inhibitors; C059688:alkoxyl radical; D016718:Arachidonic Acid; C036795:obovatol; D003094:Collagen