title: HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease.
abstract: Recently, the rs3129882 variant in intron 1 of HLA-DRA was found to be associated with late-onset sporadic Parkinson disease (PD) in Americans of European ancestry. To evaluate whether the same variant is related to PD in Chinese population, we investigated late-onset sporadic PD patients of Chinese Han ethanicity in Mainland China. We found significant difference in genotypic and allele distribution between patients and control subjects (χ²)=6.446, p=0.040 for genotypic distribution; χ²=5.762, p=0.016 for allele distribution), suggesting this variant is associated with late-onset sporadic PD in Chinese Han population.
authors.affiliation: Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
authors.forename: Xiong
authors.initials: X
authors.lastname: Deng
authors.forename: Wen
authors.initials: W
authors.lastname: Zheng
authors.forename: Hongbo
authors.initials: H
authors.lastname: Xu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Liang
authors.forename: Jin
authors.initials: J
authors.lastname: Lei
authors.forename: Xuhong
authors.initials: X
authors.lastname: Jiang
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Luo
authors.forename: Hao
authors.initials: H
authors.lastname: Deng
mesh_terms: D017668:Age of Onset; D000368:Aged; D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D059805:HLA-DR alpha-Chains / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D059805:HLA-DR alpha-Chains