title: Neuroprotective effect of Manasamitra vatakam against aluminium induced cognitive impairment and oxidative damage in the cortex and hippocampus of rat brain.
abstract: Manasamitra vatakam (MMV) has long been used as a traditional medicine in India for the treatment of psychosomatic diseases, anxiety neurosis, and stress. The present study was designed to examine the neuroprotective effect of MMV against aluminum (Al)-induced memory impairment and oxidative damage in rats. Neurotoxicity was induced by the administration of Al [100 mg/kg body weight (b.w.) per oral (p.o.)/day] to Wistar albino rats for 90 days. Al administration induced neurotoxicity as well as oxidative stress by affecting the active avoidance and memory impairment, as well as altering antioxidants, such as HSP70 protein, superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, and acetylcholinesterase. It was observed that the administration of MMV (100 mg/kg b.w./p.o./day) along with AlCl(3) improves memory performance and antioxidant activity against Al-induced neurotoxicity in rats. In conclusion, these data suggest that MMV can prevent brain damage from Al-induced neurotoxicity in rats and thus can be used as a neuroprotective agent.
authors.affiliation: Department of Pharmacology, C.L. Baid Metha College of Pharmacy and Research Foundation, Tamilnadu, India. varasubio@rediffmail.com
authors.forename: Sathiravada Veerasamy
authors.initials: SV
authors.lastname: Thirunavukkarasu
authors.forename: Subramanium
authors.initials: S
authors.lastname: Venkataraman
authors.forename: Sundararajan
authors.initials: S
authors.lastname: Raja
authors.forename: Lokesh
authors.initials: L
authors.lastname: Upadhyay
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001362:Avoidance Learning / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology; D002712:Chlorides / Q000633:toxicity*; D003072:Cognition Disorders / Q000139:chemically induced / Q000517:prevention & control*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D008297:Male; D008515:Medicine, Ayurvedic; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000517:prevention & control; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
chemical_list: D017607:Aluminum Compounds; D000975:Antioxidants; D002712:Chlorides; D018696:Neuroprotective Agents; D010936:Plant Extracts; D000077410:Aluminum Chloride