title: Advances and applications of oral cancer basic research.
abstract: Cancer of the oral cavity accounts for almost 3% of cancer cases in the world. The incidence varies widely reflecting geographic differences in exposure to risk factors. The recent rise in younger age groups and females seen in many countries is of particular concern. Treatment and management of complications, locoregional recurrence and further primary tumors result in high morbidity and mortality especially when the disease is advanced stage at initial diagnosis. Progress in cancer research has provided abundant new knowledge about cellular processes and molecular biology underlying oral carcinogenesis and tumor progression. The present review attempts to summarize the current most widely-used research approaches and their application in the prevention, diagnosis, effective treatment, and improved outcome of oral cancer.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, Canada.
authors.forename: Sabrina Daniela
authors.initials: SD
authors.lastname: da Silva
authors.forename: Alfio
authors.initials: A
authors.lastname: Ferlito
authors.forename: Robert P
authors.initials: RP
authors.lastname: Takes
authors.forename: Ruud H
authors.initials: RH
authors.lastname: Brakenhoff
authors.forename: Mev Dominguez
authors.initials: MD
authors.lastname: Valentin
authors.forename: Julia A
authors.initials: JA
authors.lastname: Woolgar
authors.forename: Carol R
authors.initials: CR
authors.lastname: Bradford
authors.forename: Juan P
authors.initials: JP
authors.lastname: Rodrigo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rinaldo
authors.forename: Michael P
authors.initials: MP
authors.lastname: Hier
authors.forename: Luiz P
authors.initials: LP
authors.lastname: Kowalski
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D019937:Diagnostic Techniques and Procedures; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000639:trends*; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D014411:Neoplastic Stem Cells; D009857:Oncogenes / Q000235:genetics; D011379:Prognosis; D012106:Research
chemical_list: D014408:Biomarkers, Tumor