title: Large regenerative nodules in a patient with Budd-Chiari syndrome after TIPS positioning while on the liver transplantation list diagnosed by Gd-EOB-DTPA MRI.
abstract: BACKGROUND
  Large regenerative nodules (LRNs) are hyperplastic benign nodules most commonly associated with Budd-Chiari syndrome (BCS), caused by outflow obstruction of the hepatic veins or vena cava. To our knowledge, no cases of LRNs arising in BCS after transjugular intrahepatic portosystemic shunt (TIPS) positioning and detected by Gd-EOB-DTPA MRI have been reported in the literature.
  
  
  METHODS
  A 58-year-old woman with BCS, on the liver transplantation (LT) list, underwent a follow-up enhanced MRI. Two years earlier, a TIPS had been placed. In 2008, recurrent hepaticoencephalopathy resistant to medical treatment fulfilled the LT criteria for BCS treated with TIPS and the patient was therefore added to the LT list. CT performed before TIPS had not detected any hepatic lesions. CT performed six months after TIPS showed its complete patency but documented two indeterminate hypervascular liver lesions.
  
  
  RESULTS
  MRI performed with Gd-EOB-DTPA revealed additional hypervascular lesions with uptake and retention of the medium in the hepatobiliary phase, thus reflecting a benign behavior of hepatocellular composition. These MRI features were related to LRNs as confirmed by histopathologic analysis.
  
  
  CONCLUSIONS
  Gd-EOB-DTPA-enhanced MRI is potentially superior to standard imaging using gadolinium chelates or spiral CT, especially for the differential diagnosis of hypervascular lesions. Gd-EOB-DTPA MRI may become the imaging method of choice for evaluating LT list patients with BCS after TIPS placement.
authors.affiliation: Radiology Unit, Department of Internal Medicine and Gastroenterology, University-Hospital Sant'Orsola-Malpighi Bologna, via Albertoni 15, Bologna, Italy. dr.matteo.renzulli@gmail.com
authors.forename: Matteo
authors.initials: M
authors.lastname: Renzulli
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Lucidi
authors.forename: Cristina
authors.initials: C
authors.lastname: Mosconi
authors.forename: Chiara
authors.initials: C
authors.lastname: Quarneti
authors.forename: Emanuela
authors.initials: E
authors.lastname: Giampalma
authors.forename: Rita
authors.initials: R
authors.lastname: Golfieri
mesh_terms: D006502:Budd-Chiari Syndrome / Q000175:diagnosis / Q000601:surgery*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D011237:Predictive Value of Tests; D012038:Regeneration; D014057:Tomography, X-Ray Computed; D014850:Waiting Lists
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA