title: Rapid improvement of osseous sarcoidosis after the treatment of pulmonary aspergillosis by itraconazole.
abstract: Osseous sarcoidosis is relatively uncommon, and treatment with corticosteroids is not always effective. Moreover, patients with an advanced stage of pulmonary sarcoidosis are sometimes infected with aspergillus in the cavities of the pulmonary lesions, and long-term use of corticosteroids should be prohibited to prevent the development of fatal invasive pulmonary aspergillosis. Here, we described a unique case of osseous sarcoidosis with pulmonary aspergillosis, showing a rapid improvement of the osseous symptoms just after the administration of the antifungal agent, itraconazole. Itraconazole is likely to become a candidate among new therapeutic agents for osseous sarcoidosis.
authors.affiliation: Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Tamada
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Nara
authors.forename: S
authors.initials: S
authors.lastname: Hisata
authors.forename: Y
authors.initials: Y
authors.lastname: Mitsuishi
authors.forename: S
authors.initials: S
authors.lastname: Muramatsu
authors.forename: K
authors.initials: K
authors.lastname: Gomi
authors.forename: M
authors.initials: M
authors.lastname: Ebina
authors.forename: T
authors.initials: T
authors.lastname: Nukiwa
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D005385:Fingers; D005500:Follow-Up Studies; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008875:Middle Aged; D055732:Pulmonary Aspergillosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012074:Remission Induction / Q000379:methods*; D012507:Sarcoidosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole