title: Ifosfamide, carboplatin and etoposide in recurrent malignant glioma.
abstract: After failure of temozolomide, there is no established standard salvage chemotherapy for patients with recurrent glioblastoma (GBM). Two phase II trials combining ifosfamide, carboplatin and etoposide chemotherapy (ICE) showed favorable results. We therefore applied the ICE protocol to 13 patients (10 GBM, 3 anaplastic astrocytomas). Partial or complete remissions were not observed. None of the 13 patients survived progression-free for 6 months. Our retrospective analysis suggests that the ICE regimen is not effective in patients with recurrent high-grade glioma if applied at second or third relapse.
authors.affiliation: Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, Bonn, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Schäfer
authors.forename: J
authors.initials: J
authors.lastname: Tichy
authors.forename: S
authors.initials: S
authors.lastname: Thanendrarajan
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Stuplich
authors.forename: F
authors.initials: F
authors.lastname: Mack
authors.forename: J
authors.initials: J
authors.lastname: Rieger
authors.forename: M
authors.initials: M
authors.lastname: Simon
authors.forename: B
authors.initials: B
authors.lastname: Scheffler
authors.forename: J
authors.initials: J
authors.lastname: Boström
authors.forename: J P
authors.initials: JP
authors.lastname: Steinbach
authors.forename: U
authors.initials: U
authors.lastname: Herrlinger
authors.forename: M
authors.initials: M
authors.lastname: Glas
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001254:Astrocytoma / Q000188:drug therapy* / Q000556:secondary; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016190:Carboplatin / Q000008:administration & dosage; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005910:Glioma / Q000188:drug therapy* / Q000556:secondary; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D000077204:Temozolomide; D017211:Treatment Failure
chemical_list: D005047:Etoposide; D003606:Dacarbazine; D016190:Carboplatin; D007069:Ifosfamide; D000077204:Temozolomide