title: An old drug for use in the prevention of sudden infant unexpected death due to vagal hypertonia.
abstract: Reflex vagal hypertonia (RVH) has been identified as a possible cause of sudden unexpected death in infants during the first year of life. Homatropine methylbromide (HM) is an anticholinergic drug known to inhibit muscarinic acetylcholine receptors, thus affecting the parasympathetic nervous system. The aim of the present study was to investigate the effects of HM on 24-h Holter electrocardiographic signs of RVH (pre-HM treatment vs post-HM treatment; post-HM treatment vs a control group of healthy infants). A total of 50 patients (mean age, 6.1 ± 2.7 months; 28 males, 22 females; 12 born pre-term) affected by RVH were enrolled in the study. Pre-HM treatment vs post-HM treatment: statistically significant differences were detected for higher heart rate, lower heart rate, mean heart rate, longer sinusal pause, presence of advanced atrio-ventricular blocks, and systolic blood pressure (p < 0.001, p < 0.00001, p < 0.02, p < 0.00001, p < 0.05, and p < 0.04, respectively). A statistically significant correlation was revealed between HM-administered dose and both average heart rate and systolic blood pressure (r = 0.93, p < 0.0001; r = 0.94, p < 0.0001, respectively). No significant differences were detected between post-HM treatment electrocardiographic data and those of the control group. By antagonizing action of the vagus nerve of the parasympathetic system on the heart, thus increasing cardiac frequency, HM treatment appears to feature a good safety profile and be highly effective in preventing transient infantile hypervagotonia, the potential cause of several cases of sudden unexpected death during the first year of life.
authors.affiliation: Department of Cardiovascular and Neurological Sciences, University of Cagliari, Policlinico Universitario, S.S. 554, bivio di Sestu-09042 Monserrato, Cagliari, Italy. piercard@inwind.it
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Bassareo
authors.forename: Valentina
authors.initials: V
authors.lastname: Bassareo
authors.forename: Donatella
authors.initials: D
authors.lastname: Manca
authors.forename: Vassilios
authors.initials: V
authors.lastname: Fanos
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mercuro
mesh_terms: D000284:Administration, Oral; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D013398:Sudden Infant Death / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome; D014326:Tropanes / Q000008:administration & dosage*; D014630:Vagus Nerve / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D014326:Tropanes; C056244:homatropine methylbromide