title: Transient receptor potential channels as therapeutic targets.
abstract: Transient receptor potential (TRP) cation channels have been among the most aggressively pursued drug targets over the past few years. Although the initial focus of research was on TRP channels that are expressed by nociceptors, there has been an upsurge in the amount of research that implicates TRP channels in other areas of physiology and pathophysiology, including the skin, bladder and pulmonary systems. In addition, mutations in genes encoding TRP channels are the cause of several inherited diseases that affect a variety of systems including the renal, skeletal and nervous system. This Review focuses on recent developments in the TRP channel-related field, and highlights potential opportunities for therapeutic intervention.
authors.affiliation: Hydra Biosciences, 790 Memorial Drive, Cambridge, Massachusetts 02139, USA.
authors.forename: Magdalene M
authors.initials: MM
authors.lastname: Moran
authors.forename: Michael Allen
authors.initials: MA
authors.lastname: McAlexander
authors.forename: Tamás
authors.initials: T
authors.lastname: Bíró
authors.forename: Arpad
authors.initials: A
authors.lastname: Szallasi
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation; D015220:Calcium Channels / Q000502:physiology; D055808:Drug Discovery; D006801:Humans; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D000074025:TRPA1 Cation Channel; D050053:TRPM Cation Channels / Q000037:antagonists & inhibitors / Q000502:physiology; D050916:TRPV Cation Channels / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D001745:Urinary Bladder Diseases / Q000188:drug therapy
chemical_list: D015220:Calcium Channels; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050053:TRPM Cation Channels; C425966:TRPM8 protein, human; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D050051:Transient Receptor Potential Channels