title: [Optimization of novel self-microemulsifying mouth dissolving films by response surface methodology].
abstract: This paper report the development of a new dosage form - self-microemulsifying mouth dissolving films, which can improve the oral bioavailability of water insoluble drugs and have good compliance. A three factor, three-level Box-Behnken design was used for optimizing formulation, investigated the effect of amounts of microcrystalline cellulose, low-substituted hydroxypropyl cellulose and hypromellose on the weight, disintegration time, cumulative release of indomethacin after 2 min, microemulsified particle size and stretchability. Optimized self-microemulsifying mouth dissolving films could fast disintegrate in (17.09 +/- 0.72) s; obtain microemulsified particle size at (28.81 +/- 3.26) nm; and release in vitro at 2 min to (66.18 +/- 1.94)%. Self-microemulsifying mouth dissolving films with broad application prospects have good compliance, strong tensile and can be released rapidly in the mouth through fast self-microemulsifying.
authors.affiliation: School of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Xiao
authors.forename: Tao
authors.initials: T
authors.lastname: Yi
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Di
authors.initials: D
authors.lastname: Huan
authors.forename: Ji-kui
authors.initials: JK
authors.lastname: He
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D045703:Emulsifying Agents / Q000737:chemistry; D004655:Emulsions; D065347:Hypromellose Derivatives; D007213:Indomethacin / Q000008:administration & dosage*; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D010316:Particle Size; D012995:Solubility; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D045703:Emulsifying Agents; D004655:Emulsions; D065347:Hypromellose Derivatives; D002482:Cellulose; D008747:Methylcellulose; C008079:hydroxypropylcellulose; C109691:microcrystalline cellulose; D007213:Indomethacin