title: Fresh-frozen human bone allograft in vertical ridge augmentation: clinical and tomographic evaluation of bone formation and resorption.
abstract: The aim of the current study is to evaluate fresh-frozen human bone allografts (FHBAs) used in vertical ridge augmentation clinically and by computed tomography, and to analyze the resulting bone formation and graft resorption. Sixteen FHBAs were grafted in the maxillae and mandibles of 9 patients. The FHBAs, which were provided by the Musculoskeletal Tissue Bank of Marilia Hospital (Unioss), were frozen at -80°C. After 7 months, dental implants were placed and bone parameters were evaluated. Vertical bone formation was measured by computerized tomography before (T0) and at 7 months (T1) after the surgical procedure. Bone graft resorption was measured clinically from a landmark screw head using a periodontal probe. The results were analyzed by Student's t-test. Significant differences existed in the bone formation values at T0 and T1, with an average change of 4.03 ± 1.69 mm. Bone graft resorption values were 1.0 ± 0.82 mm (20%). Implants were placed with varying insertion torque values (35-45 Ncm), and achieved primary stability. This study demonstrates that FHBAs promote satisfactory vertical bone formation with a low resorption rates, good density, and primary implant stability.
authors.affiliation: Department of Dental Materials and Prosthesis, São Paulo State University, UNESP, São José dos Campos Dental School, São Paulo, Brazil.
authors.forename: Luis Guilherme Scavone
authors.initials: LG
authors.lastname: Macedo
authors.forename: Luiz Antonio
authors.initials: LA
authors.lastname: Mazzucchelli-Cosmo
authors.forename: Nelson Luiz
authors.initials: NL
authors.lastname: Macedo
authors.forename: Adriana Socorro Ferreira
authors.initials: AS
authors.lastname: Monteiro
authors.forename: Wilson Roberto
authors.initials: WR
authors.lastname: Sendyk
mesh_terms: D000328:Adult; D000540:Alveolar Ridge Augmentation / Q000379:methods; D018586:Bone Banks; D001862:Bone Resorption; D016025:Bone Transplantation / Q000379:methods*; D015921:Dental Implants; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology*; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous
chemical_list: D015921:Dental Implants