title: Percutaneous intratumoral injection with pingyangmycin lipiodol emulsion for the treatment of recurrent sacrococcygeal chordomas.
abstract: This study describes fluoroscopy-guided percutaneous intratumoral injection therapy (PIIT) with a pingyangmycin lipiodol emulsion in the management of recurrent sacrococcygeal chordomas after surgical excision. Seven patients underwent a total of 22 treatment sessions (3-4 sessions per patient); treatment responses were evaluated clinically, and lesion size was determined using computed tomography (CT). Over 10-26 months of follow-up, tumor sizes and visual analogue scale (VAS) scores of all patients were decreased. No patients had complications during the follow-up period. Preliminary results showed that PIIT with pingyangmycin lipiodol emulsion under fluoroscopic guidance is effective and safe and may be considered as a treatment option.
authors.affiliation: Department of Interventional Radiology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China.
authors.forename: Jing-Yue
authors.initials: JY
authors.lastname: Guan
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: He
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Qing-Le
authors.initials: QL
authors.lastname: Zeng
authors.forename: Que-Lin
authors.initials: QL
authors.lastname: Mei
authors.forename: Yan-Hao
authors.initials: YH
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002817:Chordoma / Q000188:drug therapy*; D003287:Contrast Media / Q000008:administration & dosage; D004655:Emulsions; D004998:Ethiodized Oil / Q000008:administration & dosage*; D005260:Female; D005471:Fluoroscopy; D006801:Humans; D015552:Injections, Intralesional; D007479:Iopamidol / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010147:Pain Measurement; D015641:Radiography, Interventional; D012189:Retrospective Studies; D012445:Sacrococcygeal Region; D013125:Spinal Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D003287:Contrast Media; D004655:Emulsions; D001761:Bleomycin; C025703:bleomycetin; D004998:Ethiodized Oil; D007479:Iopamidol