title: Gd-DOTA administration at MRI in children younger than 18 months of age: immediate adverse reactions.
abstract: BACKGROUND
  There is a paucity of evidence with regard to the safety of contrast medium administration at MRI in neonates and infants.
  
  
  OBJECTIVE
  To assess immediate adverse reactions in children younger than 18 months of age during routine clinical utilization of gadoteric acid (Gd-DOTA) in a cohort of patients with nonselected indications.
  
  
  METHODS
  One hundred and four neonates and infants were enrolled in a postmarketing survey with Gd-DOTA (Dotarem, Guerbet, Roissy, France) from a single pediatric hospital. A standardized questionnaire was used to collect the patient information.
  
  
  RESULTS
  All included children, ages 3 days to 18 months, received one injection of Gd-DOTA (volume 0.6-4 ml). No immediate adverse event was reported.
  
  
  CONCLUSIONS
  This postmarketing study involving neonates and infants suggests a favorable safety profile of Gd-DOTA in routine practice.
authors.affiliation: Department of Pediatric Radiology, Hôpital Necker Enfants Malades, Paris, France. sophieemondgonsard@yahoo.fr
authors.forename: Sophie
authors.initials: S
authors.lastname: Emond
authors.forename: Francis
authors.initials: F
authors.lastname: Brunelle
mesh_terms: D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006571:Heterocyclic Compounds / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds / Q000009:adverse effects*; D011795:Surveys and Questionnaires
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate