title: Modular synthesis of 1-α- and 1-β-(indol-2-yl)-2'-deoxyribose C-nucleosides.
abstract: A simple two-step method for the selective preparation of anomerically pure 1α- and 1β-(indol-2-yl)deoxyribose derivatives was developed. The synthesis was based on the Sonogashira reaction of 1α- and 1β-ethynyldeoxyribose and 2-haloanilines followed by a Pd-complex catalyzed cyclization to the corresponding indolyldeoxyribosides.
authors.affiliation: Department of Organic and Nuclear Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 128 43, Praha 2, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Nečas
authors.forename: Denisa
authors.initials: D
authors.lastname: Hidasová
authors.forename: Michal
authors.initials: M
authors.lastname: Hocek
authors.forename: Martin
authors.initials: M
authors.lastname: Kotora
mesh_terms: D002384:Catalysis; D003500:Cyclization; D003855:Deoxyribose / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007211:Indoles; D009705:Nucleosides; D003855:Deoxyribose