title: Sertoli cells proliferate in adult rats with prenatal exposure to 3,3',4,4',5-pentachlorobiphenyl.
abstract: Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg on days 13-19 postconception. Immunohistochemical evidence of proliferating cell nuclear antigen (PCNA) expression and electron microscope observation of mitotic figures confirmed the proliferation. Because the serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone concentrations were similar to those of vehicle-treated rats, a direct endocrine cause for the observed effects was unlikely.
authors.affiliation: Department of Toxicology and Biochemistry, Azabu University School of Veterinary Medicine, Sagamihara, Kanagawa, Japan. wakui@azabu-u.ac.jp
authors.forename: Shin
authors.initials: S
authors.lastname: Wakui
authors.forename: Tomoko
authors.initials: T
authors.lastname: Muto
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hano
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D004965:Estrogen Antagonists / Q000633:toxicity*; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D008938:Mitosis / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012708:Sertoli Cells / Q000187:drug effects* / Q000378:metabolism
chemical_list: D004965:Estrogen Antagonists; D018809:Proliferating Cell Nuclear Antigen; D011078:Polychlorinated Biphenyls; C023035:3,4,5,3',4'-pentachlorobiphenyl