title: Combination of two fat saturation pulses improves detectability of glucose signals in carbon-13 MR spectroscopy.
abstract: In order to improve the fat suppression performance of in vivo (13)C-MRS operating at 3.0 Tesla, a phantom model study was conducted using a combination of two fat suppression techniques; a set of pulses for frequency (chemical shift) selective suppression (CHESS), and spatial saturation (SAT). By optimizing the slab thickness for SAT and the irradiation bandwidth for CHESS, the signals of the -(13)CH(3) peak at 49 ppm and the -(13)CH(2)- peak at 26 ppm simulating fat components were suppressed to 5% and 19%, respectively. Combination of these two fat suppression pulses achieved a 53% increase of the height ratio of the glucose C1β peak compared with the sum of all other peaks, indicating better sensitivity for glucose signal detection. This method will be applicable for in vivo (13)C-MRS by additional adjustment with the in vivo relaxation times of the metabolites.
authors.affiliation: Research Program for Carbon Ion Therapy and Diagnostic Imaging, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: Moyoko
authors.initials: M
authors.lastname: Tomiyasu
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Matsuda
authors.forename: James
authors.initials: J
authors.lastname: Tropp
authors.forename: Toshiro
authors.initials: T
authors.lastname: Inubushi
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Nakai
mesh_terms: D002247:Carbon Isotopes; D005947:Glucose / Q000378:metabolism*; D008055:Lipids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging
chemical_list: D002247:Carbon Isotopes; D008055:Lipids; D005947:Glucose