title: [Autologous tissue engineering by means of distraction osteogenesis: Biomechanical considerations].
abstract: Tissue engineering consists in producing functional replacement tissue. Distraction osteogenesis is a tissue engineering technique that uses the mechanical environment of cells to induce tissue regeneration, without need for exogenous biochemical factors. A better understanding of the optimal mechanical conditions of distraction callus stretching may reduce the duration, discomfort, and even social impact of distraction protocols, and complications and failures. We present the current state of knowledge in this field by addressing the fundamentals of elongating bone tissue biomechanics, the influence of rhythm and rate of distraction, and that of vectors and stability. Finally, we present the innovations currently studied, which may modify our clinical protocol in the short term.
authors.affiliation: Service de chirurgie maxillofaciale et stomatologie, université Paris 6 - Pierre-et-Marie-Curie, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013 Paris, France. thomas.schouman@psl.aphp.fr
authors.forename: T
authors.initials: T
authors.lastname: Schouman
authors.forename: G
authors.initials: G
authors.lastname: Raoul
authors.forename: G
authors.initials: G
authors.lastname: Dubois
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001861:Bone Regeneration; D002146:Bony Callus / Q000502:physiology; D006801:Humans; D008334:Mandible / Q000601:surgery; D019857:Osteogenesis, Distraction / Q000295:instrumentation / Q000379:methods; D013997:Time Factors; D023822:Tissue Engineering