title: Biomechanical factors influencing the beginning and development of osteoarthritis in the hip joint.
abstract: Osteoarthritis (OA) can be used as a common name for a group of overlapping pathological conditions when the balance between the processes of degradation and synthesis, in individual parts of the cartilage, is disturbed and leads to gradual cartilage destruction. A preventive approach toward OA helps with a timely diagnosis and subsequent treatment of this disease. One of the significant risk factors affecting development of hip joint OA is the mechanism and magnitude of mechanical loading on the joint. The main motivation for this work was to verify the hypothesis involving a pathologic cycle (overloading - change of locomotion - overloading) as contributory to the development of OA and whether it can be stopped, or at least partly decelerated, by a suitable change of movement stereotypes. Providing that there is a natural balance of muscular action, from the beginning of OA, the development of OA can be significantly decelerated. The return to a natural force balance can be achieved using suitable exercise and strengthening of muscular structures. In order to verify the hypothesis, we undertook experimental measurements of gait kinematics and a computational analysis of the hip joint using the Finite Element Method.
authors.affiliation: Laboratory of Biomechanics, Czech Technical University in Prague. zdenek.horak@fs.cvut.cz
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Horak
authors.forename: Petr
authors.initials: P
authors.lastname: Kubovy
authors.forename: Martin
authors.initials: M
authors.lastname: Stupka
authors.forename: Jitka
authors.initials: J
authors.lastname: Horakova
mesh_terms: D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000503:physiopathology; D003196:Computer Graphics; D005260:Female; D020342:Finite Element Analysis; D005684:Gait / Q000502:physiology; D006621:Hip Joint / Q000503:physiopathology*; D006801:Humans; D008297:Male; D015207:Osteoarthritis, Hip / Q000503:physiopathology* / Q000534:rehabilitation; D026741:Physical Therapy Modalities; D004856:Postural Balance / Q000502:physiology; D016059:Range of Motion, Articular / Q000502:physiology; D018570:Risk Assessment; D012984:Software; D016138:Walking / Q000502:physiology; D016474:Weight-Bearing / Q000502:physiology