title: [New producers of biologically active compounds--fungal strains of the genus Penicillium isolated from permafrost].
abstract: Screening of producers of secondary metabolites was carried out among 25 fungal strains of Penicillium genus isolated from permafrost in Arctic and Antarctic regions and Kamchatka. Nearly 50% of the investigated strains synthesize biologically active substances of alkaloid nature: ergot alkaloids, diketopiperazines, and quinoline derivatives. A large group of the identified metabolites belongs to mycotoxins. A strain of Penicillium waksmanii was found producing epoxiagroclavine-I and quinocitrinins. The main physiological and biochemical characteristics of this producer were investigated.
authors.forename: T V
authors.initials: TV
authors.lastname: Antipova
authors.forename: V P
authors.initials: VP
authors.lastname: Zhelifonova
authors.forename: B P
authors.initials: BP
authors.lastname: Baskunov
authors.forename: S M
authors.initials: SM
authors.lastname: Ozerskaia
authors.forename: N E
authors.initials: NE
authors.lastname: Ivanushkina
authors.forename: A G
authors.initials: AG
authors.lastname: Kozlovskiĭ
mesh_terms: D000864:Antarctic Regions; D001110:Arctic Regions; D002855:Chromatography, Thin Layer; D003080:Cold Temperature; D054659:Diketopiperazines / Q000032:analysis / Q000378:metabolism*; D004873:Ergolines / Q000032:analysis / Q000378:metabolism*; D016533:Mycological Typing Techniques; D009183:Mycotoxins / Q000032:analysis / Q000096:biosynthesis*; D010407:Penicillium / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D011804:Quinolines / Q000032:analysis / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D054659:Diketopiperazines; D004873:Ergolines; D009183:Mycotoxins; D011804:Quinolines; C476115:quinocitrinine B; C004465:agroclavine