title: The cardiovascular effects of central hydrogen sulfide are related to K(ATP) channels activation.
abstract: Hydrogen sulfide (H(2)S), an endogenous "gasotransmitter", exists in the central nervous system. However, the central cardiovascular effects of endogenous H(2)S are not fully determined. The present study was designed to investigate the central cardiovascular effects and its possible mechanism in anesthetized rats. Intracerebroventricular (icv) injection of NaHS (0.17~17 microg) produced a significant and dose-dependent decrease in blood pressure (BP) and heart rate (HR) (P < 0.05) compared to control. The higher dose of NaHS (17 microg, n = 6) decreased BP and HR quickly of rats and 2 of them died of respiratory paralyse. Icv injection of the cystathionine beta-synthetase (CBS) activator s-adenosyl-L-methionine (SAM, 26 microg) also produced a significant hypotension and bradycardia, which were similar to the results of icv injection of NaHS. Furthermore, the hypotension and bradycardia induced by icv NaHS were effectively attenuated by pretreatment with the K(ATP) channel blocker glibenclamide but not with the CBS inhibitor hydroxylamine. The present study suggests that icv injection of NaHS produces hypotension and bradycardia, which is dependent on the K(ATP) channel activation.
authors.affiliation: Department of Clinical Laboratory, San Ai Tang Hospital, Lanzhou, China.
authors.forename: W-Q
authors.initials: WQ
authors.lastname: Liu
authors.forename: C
authors.initials: C
authors.lastname: Chai
authors.forename: X-Y
authors.initials: XY
authors.lastname: Li
authors.forename: W-J
authors.initials: WJ
authors.lastname: Yuan
authors.forename: W-Z
authors.initials: WZ
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000139:chemically induced / Q000503:physiopathology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006862:Hydrogen Sulfide / Q000008:administration & dosage* / Q000378:metabolism*; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology*; D015640:Ion Channel Gating / Q000187:drug effects; D054086:KATP Channels / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D054086:KATP Channels; D006862:Hydrogen Sulfide