title: Furocoumarin derivatives from radix Angelicae dahuricae and their effects on RXRα transcriptional regulation.
abstract: A novel furocoumarin derivative named oxyalloimperatorin (1), together with seventeen furocoumarins 2-18 were isolated from the radix of Angelica dahurica. The chemical structure of new metabolite was characterized by analysis of IR, NMR, and HR-ESI-MS spectroscopic data. Among the isolated compounds, 13, 16, and 18 (each at 20 μM) could significantly promote the gene transcriptional function of nuclear receptor RXRα. While 7-9, 13, 14, and the new structure 1 (each at 20 μM) showed significant reduction in RXRα gene transcriptional activities induced by 9-cis-retinoid acid. The findings indicated that these furocoumarin skeleton derivatives might hold beneficial effects on many intractable diseases, such as cancer and metabolic diseases, due to their potential activities on regulating the transcriptional activation function of RXRα.
authors.affiliation: School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China.
authors.forename: Dong-Ping
authors.initials: DP
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Luo
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.forename: Xiao-Kun
authors.initials: XK
authors.lastname: Zhang
authors.forename: Quan-Cheng
authors.initials: QC
authors.lastname: Chen
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Chen
mesh_terms: D000085:Acetates / Q000737:chemistry; D000077556:Alitretinoin; D029969:Angelica / Q000737:chemistry*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000473:pathology; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D017930:Genes, Reporter; D057809:HEK293 Cells; D006801:Humans; D008156:Luciferases / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010957:Plasmids; D047490:Retinoid X Receptor alpha / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation / Q000187:drug effects*; D014162:Transfection; D014212:Tretinoin / Q000494:pharmacology
chemical_list: D000085:Acetates; D011564:Furocoumarins; D010936:Plant Extracts; D047490:Retinoid X Receptor alpha; D000077556:Alitretinoin; D014212:Tretinoin; C007650:ethyl acetate; D008156:Luciferases