title: 7-chloroquinolin-4-yl arylhydrazone derivatives: synthesis and antifungal activity.
abstract: Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents.
authors.affiliation: NuQuiA – Núcleo de Química Aplicada, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário, Pelotas, RS, Brazil.
authors.forename: Auri R
authors.initials: AR
authors.lastname: Duval
authors.forename: Pedro H
authors.initials: PH
authors.lastname: Carvalho
authors.forename: Maieli C
authors.initials: MC
authors.lastname: Soares
authors.forename: Daniela P
authors.initials: DP
authors.lastname: Gouvêa
authors.forename: Geonir M
authors.initials: GM
authors.lastname: Siqueira
authors.forename: Rafael G
authors.initials: RG
authors.lastname: Lund
authors.forename: Wilson
authors.initials: W
authors.lastname: Cunico
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D006835:Hydrazones; D011804:Quinolines