title: SDF-1/CXCR4 axis in myelodysplastic syndromes: correlation with angiogenesis and apoptosis.
abstract: To study the role of SDF-1/CXCR4 axis in MDS, the expression of SDF-1 and CXCR4, VEGF, MVD and apoptosis were measured in MDS. The results showed that the expression of SDF-1 of the low-grade MDS is higher than that of the high-grade MDS and the control. The high-grade MDS had a significantly higher CXCR4 expression on CD34+ cell than low-grade MDS and the control. It was suggested that the SDF-1/CXCR4 axis play an important role in MDS. Apoptosis was significantly increased in low-grade MDS, compared with high-grade MDS. The expression of VEGF and MVD were higher in the high-grade MDS than in the low-grade MDS. There are positive correlations between SDF-1 and apoptosis in the low-grade MDS. For the high-grade MDS, there were positive correlations between CXCR4 and VEGF, and between SDF-1 concentration and MVD. The apoptosis is one of the hallmarks for low-grade MDS and the angiogenesis for high-grade MDS. A refined understanding of the roles that SDF-1/CXCR4 axis and its correlation with angiogenesis and apoptosis play in MDS will fuel the development of therapies that can be targeted to the SDF-1/CXCR4 axis.
authors.affiliation: Department of Hematology, TianJin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, PR China. zhangzhurensci@yahoo.cn
authors.forename: Yizhuo
authors.initials: Y
authors.lastname: Zhang
authors.forename: Haifeng
authors.initials: H
authors.lastname: Zhao
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhao
authors.forename: Lu
authors.initials: L
authors.lastname: Sun
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Zhi
authors.forename: Xiaoxiong
authors.initials: X
authors.lastname: Wu
authors.forename: Wenrong
authors.initials: W
authors.lastname: Huang
authors.forename: Wanming
authors.initials: W
authors.lastname: Da
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis; D016022:Case-Control Studies; D054377:Chemokine CXCL12 / Q000378:metabolism*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000378:metabolism* / Q000473:pathology*; D060787:Neoplasm Grading; D009389:Neovascularization, Pathologic; D011379:Prognosis; D019718:Receptors, CXCR4 / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D055815:Young Adult
chemical_list: C515255:CXCL12 protein, human; C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; D019718:Receptors, CXCR4; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A