title: [The geroprotective effect of the amino acids and tripeptides in the cartilage tissue culture in rats].
abstract: The effect of 20 coded amino acids and synthetic bioregulatory tripeptides, in the effective concentration 0.05 ng/ml, was investigated in organotypic tissue culture on the cell proliferation development in the cartilage tissue explants in young 3 and old 24 months old rats. The number of the amino acid stimulated proliferation was decreased in the tissue culture from the old rats in 6 times, as compared to the young rats. The tripeptides demonstrated the stimulated proliferation effect in the tissue culture both from the young and old animals, what is a base for the further study as the geroprotective preparations.
authors.forename: A V
authors.initials: AV
authors.lastname: Smirnov
authors.forename: N I
authors.initials: NI
authors.lastname: Chalisova
authors.forename: G A
authors.initials: GA
authors.lastname: Ryzhak
authors.forename: E A
authors.initials: EA
authors.lastname: Kontsevaia
authors.forename: M A
authors.initials: MA
authors.lastname: Voĭtsekhovskaia
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000473:pathology*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002356:Cartilage / Q000187:drug effects* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D046509:Tissue Culture Techniques
chemical_list: D000596:Amino Acids; D009842:Oligopeptides