title: [Effects of ferulic acid on bFGF-treated PC12 cells].
abstract: OBJECTIVE
  To explore the effect and mechanism of ferulic acid on differentiation in bFGF-treated PC12 cells.
  
  
  METHODS
  The length of neurite outgrowth and the percentage of PC12 cells induced in the presence of 0 ng/mL or 1 ng/mL bFGF were assayed.
  
  
  RESULTS
  Compared with that of control group,ferulic acid could enhance the differentiation effect of bFGF (1 ng/mL) in PC12 cells (P < 0.01) and the enhancing effect could be blocked by the specific MAPK kinase inhibitor, PD98059.
  
  
  CONCLUSIONS
  Ferulic acid potentiates neurite outgrowth in bFGF-treated PC12 cells by MAPK-dependent signaling pathway.
authors.affiliation: Department of Pharmacology, Medical College, Jinan University, China. tlinlf@hotmail.com
authors.forename: Lian-feng
authors.initials: LF
authors.lastname: Lin
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.forename: Yong-chang
authors.initials: YC
authors.lastname: Lai
authors.forename: Ju-nian
authors.initials: JN
authors.lastname: Su
authors.forename: Huan-min
authors.initials: HM
authors.lastname: Luo
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D003373:Coumaric Acids / Q000008:administration & dosage / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors; D016501:Neurites / Q000187:drug effects* / Q000502:physiology; D016716:PC12 Cells / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D003373:Coumaric Acids; D005419:Flavonoids; D016222:Fibroblast Growth Factor 2; C004999:ferulic acid; D020928:Mitogen-Activated Protein Kinases; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one