title: Elevated serum neopterin levels in acetaminophen-induced liver injury.
abstract: Neopterin is synthesized in macrophage/Kupffer cells by interferon-gamma and other cytokines. This study aimed to evaluate the utility of using neopterin as a biomarker of acetaminophen (APAP)-induced liver injury. Wistar rats, randomly divided into two groups (APAP and normal), received APAP (1.0 g/kg) and distilled water, respectively, by gastric tube. The APAP group had a higher degree of liver necrosis than the control group. The APAP group also had significantly higher serum neopterin levels than the normal group. Serum neopterin levels correlated with serum AST, ALT activities, and degree of necrosis. This study demonstrates the preclinical utility of neopterin as a biomarker for the animal model of APAP-induced liver injury. Further research studies are required to determine the preclinical opportunities of using neopterin as a marker of APAP-induced liver injury.
authors.affiliation: Department of Internal Medicine, Gulhane Military Medical Academy, 06018 Etlik, Ankara, Turkey.
authors.forename: Seref
authors.initials: S
authors.lastname: Demirbas
authors.forename: Erdinc
authors.initials: E
authors.lastname: Cakir
authors.forename: Emin Ozgur
authors.initials: EO
authors.lastname: Akgul
authors.forename: Melik
authors.initials: M
authors.lastname: Seyrek
authors.forename: Tuncer
authors.initials: T
authors.lastname: Cayci
authors.forename: Yasemin Gulcan
authors.initials: YG
authors.lastname: Kurt
authors.forename: Bulent
authors.initials: B
authors.lastname: Uysal
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Aydin
authors.forename: Bulent
authors.initials: B
authors.lastname: Kurt
authors.forename: Halil
authors.initials: H
authors.lastname: Yaman
authors.forename: Mehmet Kemal
authors.initials: MK
authors.lastname: Erbil
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D009336:Necrosis; D019798:Neopterin / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D015415:Biomarkers; D000082:Acetaminophen; D019798:Neopterin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase