title: Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism.
abstract: Diabetes is often associated with pituitary-dependent hyperadrenocorticism (PDH). Hypercortisolism causes insulin resistance and affects β-cell function. The purpose of this study was to test if daily administration of a long-acting insulin analogue during the first month of anti-PDH treatment can prevent progress to diabetes in these animals. Twenty-six PDH dogs were divided into three groups: one group with glycaemia <5.83 mmol/L and two groups with glycaemia >5.83 mmol/L and <9.35 mmol/L, one of which received insulin detemir during 4 months. Dogs with glycaemia <5.83 mmol/L and those with glycaemia >5.83 mmol/L which received insulin did not develop diabetes. In the non-insulin group, 6/7 dogs developed diabetes after the third month. There is a 13-fold higher risk of diabetes in dogs with glycaemia >5.83 mmol/L and no insulin treatment. Administering insulin detemir to dogs with PDH and glycaemia >5.83 mmol/L could prevent progression to diabetes.
authors.affiliation: Cátedra Clínica Médica de Pequeños Animales-Hospital Escuela Medicina Veterinaria, Unidad de Endocrinología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, 1427, Av. Chorroarin 280, Argentina.
authors.forename: D D
authors.initials: DD
authors.lastname: Miceli
authors.forename: M F
authors.initials: MF
authors.lastname: Gallelli
authors.forename: M F
authors.initials: MF
authors.lastname: Cabrera Blatter
authors.forename: B
authors.initials: B
authors.lastname: Martiarena
authors.forename: M M
authors.initials: MM
authors.lastname: Brañas
authors.forename: L R
authors.initials: LR
authors.lastname: Ortemberg
authors.forename: N V
authors.initials: NV
authors.lastname: Gómez
authors.forename: V A
authors.initials: VA
authors.lastname: Castillo
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000209:etiology / Q000517:prevention & control*; D004283:Dog Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D005260:Female; D007328:Insulin / Q000097:blood*; D000069057:Insulin Detemir; D049528:Insulin, Long-Acting / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D049528:Insulin, Long-Acting; D014280:Triglycerides; D000069057:Insulin Detemir; D000324:Adrenocorticotropic Hormone; D002784:Cholesterol