title: [Effect of mitomycin C on corneal regrowth after laser-assisted sub-epithelial keratectomy (LASEK)].
abstract: OBJECTIVE
  To study the effect of mitomycin C (MMC) on the corneal regrowth after laser-assisted sub-epithelial keratectomy (LASEK).
  
  
  METHODS
  We performed a prospective, controlled, observer-masked study of 64 consecutive eyes scheduled to undergo LASEK to correct their myopia. The patients were divided into two age-matched groups, with group 1 including 32 eyes in which the ablation depth was ≤ 50 μm and received no MMC. Group 2 consisted of 32 eyes in which the ablation depth exceeded 50 μm and were treated with intra-operative 0.02% MMC for 30 seconds over the ablated zone. A masked observer measured the central corneal thickness (CCT) 1 and 3 months after surgery. We compared the change in CCT between both groups up to 3 months after surgery.
  
  
  RESULTS
  The mean patient age was 31.5 years (SD 4.6) and 31.6 (SD 8.7) years in groups 1 and 2, respectively (P=.9). Group 1 showed a mean CCT of 444.0 (SD 41.3) μm one month after surgery and 450.3 (SD 43.5) μm three months after surgery (P=.04). CCT in group 2 was 399.7 (SD 31.2) μm and 407.9 (SD 32.6) μm one and three months after surgery, respectively (P=.006). The difference in the CCT increases between both groups was not statistically significant (P=.6).
  
  
  CONCLUSIONS
  A single intraoperative application of 0.02% MMC for 30 seconds did not seem to cause a substantial change in the post-surgical corneal thickening expected after LASEK.
authors.affiliation: Vissum, Hospital Oftalmológico, Madrid, España. lbenito@vissum.com
authors.forename: L
authors.initials: L
authors.lastname: De Benito-Llopis
authors.forename: M A
authors.initials: MA
authors.lastname: Teus
authors.forename: P
authors.initials: P
authors.lastname: Drake-Casanova
mesh_terms: D000328:Adult; D002455:Cell Division / Q000187:drug effects; D003318:Corneal Opacity / Q000517:prevention & control*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006131:Growth Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007430:Intraoperative Care; D049008:Keratectomy, Subepithelial, Laser-Assisted; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D009216:Myopia / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D016037:Single-Blind Method; D017154:Stromal Cells / Q000187:drug effects; D055815:Young Adult
chemical_list: D006131:Growth Inhibitors; D016685:Mitomycin