title: Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy.
abstract: Dose-dependent PR interval prolongation has been reported in preclinical studies of lacosamide (LCM), a recently U.S. Food and Drug Administration (FDA)-approved antiepileptic drug (AED). Here we report a case of second-degree atrioventricular block (AV) block caused by the addition of LCM to other AEDs known to prolong the PR interval, resulting in hypotension and bradycardia, with consequent seizure exacerbation. The patient recovered completely after withdrawal of LCM. This case demonstrates the need for caution and interval cardiac testing when adding LCM to other AEDs known to prolong the PR interval.
authors.affiliation: Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901-1962, USA.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Nizam
authors.forename: Krishna
authors.initials: K
authors.lastname: Mylavarapu
authors.forename: Dwithiya
authors.initials: D
authors.lastname: Thomas
authors.forename: Klara
authors.initials: K
authors.lastname: Briskin
authors.forename: Brenda
authors.initials: B
authors.lastname: Wu
authors.forename: Deepak
authors.initials: D
authors.lastname: Saluja
authors.forename: Stephen
authors.initials: S
authors.lastname: Wong
mesh_terms: D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D054537:Atrioventricular Block / Q000139:chemically induced* / Q000503:physiopathology; D004562:Electrocardiography; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D000078334:Lacosamide; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide