title: Blood derived stem cells: an ameliorative therapy in veterinary ophthalmology.
abstract: Stem cell technology has evoked considerable excitement among people interested in the welfare of animals, as it has suggested the potential availability of new tools for several pathologies, including eye disease, which in many cases is considered incurable. One such example is ulcerative keratitis, which is very frequent in horses. Because some of these corneal ulcers can be very severe, progress rapidly and, therefore, can be a possible cause of vision loss, it is important to diagnose them at an early stage and administer an appropriate treatment, which can be medical, surgical, or a combination of both. The therapeutic strategy should eradicate the infection in order to reduce or stop destruction of the cornea. In addition, it should support the corneal structures and control the uveal reaction, and the pain associated with it, in order to minimize scarring. In this study, we address how stem cells derived from peripheral blood can be used also in ophthalmological pathologies. Our results demonstrate that this treatment protocol improved eye disease in four horse cases, including corneal ulcers and one case of retinal detachment. In all cases, we detected a decrease in the intense inflammatory reaction as well as the restoration of the epithelial surface of the central cornea.
authors.affiliation: Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy. gabriellamarfe@libero.it
authors.forename: Gabriella
authors.initials: G
authors.lastname: Marfe
authors.forename: Mina
authors.initials: M
authors.lastname: Massaro-Giordano
authors.forename: Marco
authors.initials: M
authors.lastname: Ranalli
authors.forename: Eliana
authors.initials: E
authors.lastname: Cozzoli
authors.forename: Carla
authors.initials: C
authors.lastname: Di Stefano
authors.forename: Valentina
authors.initials: V
authors.lastname: Malafoglia
authors.forename: Marco
authors.initials: M
authors.lastname: Polettini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gambacurta
mesh_terms: D000818:Animals; D001733:Bites and Stings / Q000473:pathology / Q000628:therapy / Q000662:veterinary; D003320:Corneal Ulcer / Q000473:pathology / Q000628:therapy / Q000662:veterinary; D005128:Eye Diseases / Q000473:pathology / Q000628:therapy* / Q000662:veterinary*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000662:veterinary*; D006734:Horse Diseases / Q000473:pathology / Q000628:therapy*; D006736:Horses; D007634:Keratitis / Q000473:pathology / Q000628:therapy / Q000662:veterinary; D008297:Male; D012163:Retinal Detachment / Q000473:pathology / Q000628:therapy / Q000662:veterinary; D014605:Uveitis / Q000469:parasitology / Q000628:therapy / Q000662:veterinary