title: Rare case of spina bifida in both twins with possible genetic basis.
abstract: Neural tube defects (NTD) are a group of congenital malformations of the brain and spine, the etiology of which is still debated. Although presumed to be the consequence of interactions between genetic and environmental factors, so far, it is not known which genes are involved in the pathogenesis of these malformations. NTD affecting both fetuses in a twin gestation is a rare event. In view of this rarity, we present a case of dichorionic diamniotic twin pregnancy with spina bifida in both fetuses concordantly. This gestation was preceeded by another dichorionic diamniotic twin pregnancy that was complicated by placental abruption.
authors.affiliation: Femical Women's Health Clinic, Memorial Atasehir Hospital, Istanbul, Turkey.
authors.forename: Arda
authors.initials: A
authors.lastname: Lembet
authors.forename: Evin Nil
authors.initials: EN
authors.lastname: Uğurlu
authors.forename: Taner
authors.initials: T
authors.lastname: Toprak
authors.forename: Ercan
authors.initials: E
authors.lastname: Bastu
mesh_terms: D000328:Adult; D004200:Diseases in Twins / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D006801:Humans; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D059285:Pregnancy, Twin; D011296:Prenatal Diagnosis; D016135:Spinal Dysraphism / Q000175:diagnosis* / Q000235:genetics