title: Low dose 4-MBC effect on neuroendocrine regulation of reproductive axis in adult male rats.
abstract: 4-Methylbenzylidene camphor (4-MBC) is an ultraviolet absorbent. The objective of this paper was to evaluate the effect of 4-MBC low-dose exposure on the neuroendocrine reproductive regulation in male rats. Wistar male adult rats were injected sc. with 4-MBC during 5 days with a dose of 2 and 10mg/kg or during 2 days with a dose of 2 and 20mg/kg. In all rats serum prolactin, LH and FSH concentration were assayed. The hypothalamus of rats injected during 2 days were also dissected to study GnRH release. Rats that received 2 and 10mg/kg of 4-MBC during 5 days showed a decrease in the LH and FSH serum concentration. In rats injected during 2 days, serum LH decreased with 2 and 20mg/kg and FSH decreased with 2mg/kg of 4-MBC. In vitro hypothalamic GnRH release also decreased in these animals. These results show that low doses of 4-MBC inhibit the reproductive axis in adult male rats.
authors.affiliation: Department of Physiology, Medicine School, University of Buenos Aires (UBA), Buenos Aires, Argentina.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Carou
authors.forename: Osvaldo J
authors.initials: OJ
authors.lastname: Ponzo
authors.forename: Romina P
authors.initials: RP
authors.lastname: Cardozo Gutierrez
authors.forename: Berta
authors.initials: B
authors.lastname: Szwarcfarb
authors.forename: Maria L
authors.initials: ML
authors.lastname: Deguiz
authors.forename: Roxana
authors.initials: R
authors.lastname: Reynoso
authors.forename: Silvia
authors.initials: S
authors.lastname: Carbone
authors.forename: Jaime A
authors.initials: JA
authors.lastname: Moguilevsky
authors.forename: Pablo
authors.initials: P
authors.lastname: Scacchi