title: Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations.
abstract: BACKGROUND
  The authors previously showed that the C→T polymorphism (rs6929846) of butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction in Japanese individuals. Given that metabolic syndrome (MetS) is an important risk factor for myocardial infarction, the association of the rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to MetS.
  
  
  OBJECTIVE
  The aim of the present study was to examine the relation of the rs6929846 of BTN2A1 to MetS in East Asian populations.
  
  
  METHODS
  The study population comprised 5210 Japanese or Korean individuals (3982 individuals with MetS, 1228 controls) from three independent subject panels. Japanese subject panels A and B comprised 1322 individuals with MetS and 654 controls, and 1909 individuals with MetS and 170 controls, respectively, whereas the Korean population samples comprised 751 individuals with MetS and 404 controls.
  
  
  RESULTS
  Comparison of genotype distributions using the χ(2) test revealed that the genotype distributions and allele frequencies of rs6929846 were significantly (p<0.05) associated with MetS in Japanese subject panels A (T allele frequency: MetS, 0.091; controls, 0.054; p=6.1×10(-5)) and B (T allele frequency: MetS, 0.091; controls, 0.039; p=0013) but not in the Korean population samples (T allele frequency: MetS, 0.102; controls, 0.125; p=0.0997). Multivariable logistic regression analysis with adjustment for covariates revealed that the rs6929846 of BTN2A1 was significantly (p<0.017) associated with MetS in Japanese subject panel A (p=0.0055, OR 1.97) and in all individuals (p=0.0038, OR 1.38), with the T allele representing a risk factor for this condition.
  
  
  CONCLUSIONS
  BTN2A1 may be a susceptible gene for MetS in Japanese individuals.
authors.affiliation: Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Oguri
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kato
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Fujimaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Horibe
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yokoi
authors.forename: Sachiro
authors.initials: S
authors.lastname: Watanabe
authors.forename: Kei
authors.initials: K
authors.lastname: Satoh
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Masashi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hiroto
authors.initials: H
authors.lastname: Yoshida
authors.forename: Shoji
authors.initials: S
authors.lastname: Shinkai
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Dong-jik
authors.initials: DJ
authors.lastname: Shin
authors.forename: Jon Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000368:Aged; D000483:Alleles; D000071797:Butyrophilins; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D024821:Metabolic Syndrome / Q000208:ethnology / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D000071797:Butyrophilins; D008562:Membrane Glycoproteins