title: Evidence for the involvement of the serotonergic, noradrenergic, and dopaminergic systems in the antidepressant-like action of riparin III obtained from Aniba riparia (Nees) Mez (Lauraceae) in mice.
abstract: Previous work has shown that intraperitoneal administration of riparin III (ripIII) reduces immobility time in the forced swimming test (FST), which suggests potential antidepressant activity. As the mechanism of action is not completely understood, this study is aimed at investigating the antidepressant-like action of ripIII. Following intraperitoneal administration of ripIII at doses of 25 and 50 mg/kg, there were decreases in the immobility time in the FST and tail suspension test without accompanying changes in ambulation (data not shown). The pretreatment of mice with sulpiride (50 mg/kg, i.p.), prazosin (1 mg/kg, i.p.), yohimbine (1 mg/kg, i.p.), and p-chlorophenylalanine (PCPA, 100 mg/kg, i.p. for, four consecutive days) significantly prevented the anti-immobility effect of ripIII in the FST. On the other hand, the anti-immobility effect of ripIII (50 mg/kg, v.o.) was not altered by pretreatment of mice with SCH23390 (15 μg/kg, i.p.) Furthermore, ripIII potentiated the sleeping latency and sleeping time of the pentobarbital-induced sleeping time test and also potentiated apomorphine (16 mg/kg, i.p.)-induced hypothermia in mice. In conclusion, the present study provides evidence that the antidepressant-like effect of ripIII is dependent on its interaction with the serotonergic, noradrenergic (α₁- and α₂- receptors), and dopaminergic (dopamine D₂ receptors) systems.
authors.affiliation: Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
authors.forename: Carla Thiciane Vasconcelos
authors.initials: CT
authors.lastname: Melo
authors.forename: Alyne Mara Rodrigues
authors.initials: AM
authors.lastname: de Carvalho
authors.forename: Brinell Arcanjo
authors.initials: BA
authors.lastname: Moura
authors.forename: Caroline Porto Leite
authors.initials: CP
authors.lastname: Teixeira
authors.forename: Leonardo Freire
authors.initials: LF
authors.lastname: Vasconcelos
authors.forename: Mariana Lima
authors.initials: ML
authors.lastname: Feitosa
authors.forename: Gersilene Valente
authors.initials: GV
authors.lastname: de Oliveira
authors.forename: José Maria
authors.initials: JM
authors.lastname: Barbosa-Filho
authors.forename: Stanley Juan
authors.initials: SJ
authors.lastname: Chavez Gutierrez
authors.forename: Marta Maria
authors.initials: MM
authors.lastname: de França Fonteles
authors.forename: Silvânia Maria Mendes
authors.initials: SM
authors.lastname: Vasconcelos
authors.forename: Francisca Cléa Florenço
authors.initials: FC
authors.lastname: de Sousa
mesh_terms: D000284:Administration, Oral; D058646:Adrenergic alpha-1 Receptor Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D001549:Benzamides / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001938:Brazil; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D020834:Ethnopharmacology; D005638:Fruit / Q000737:chemistry / Q000254:growth & development; D006172:Guyana; D019770:Lauraceae / Q000737:chemistry / Q000254:growth & development; D008297:Male; D051379:Mice; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000819:agonists / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D014439:Tyramine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D058646:Adrenergic alpha-1 Receptor Agonists; D058647:Adrenergic alpha-2 Receptor Agonists; D000928:Antidepressive Agents; D001549:Benzamides; D018491:Dopamine Agonists; D017448:Receptors, Dopamine D2; D017366:Serotonin Receptor Agonists; C087987:riparin III; D014439:Tyramine