title: Cultivated microalgae and the carotenoid fucoxanthin from Odontella aurita as potent anti-proliferative agents in bronchopulmonary and epithelial cell lines.
abstract: The antiproliferative activities of several extracts from cultivated microalgae in France have been studied against bronchopulmonary and epithelial cell lines, respectively (A549, NSCLC-N6 and SRA 01/04). The algal extracts, of Diatomae (Odontella aurita, Chaetoseros sp.), as well as of Haptophyceae: Isochrisys aff. galbana, appeared as the most active among all the assayed species, expressing a broad spectrum of in vitro antiproliferative activity of well-differentiated pathologic cells such as NSCLC-N6 by terminal differentiation. Bio-guided fractionation of the above referred extracts, led us to the isolation, of the carotenoid fucoxanthin. Fucoxanthin has been structurally determined, through modern spectral means and has been studied separately for its activities.
authors.affiliation: Laboratoire de Pharmacologie Marine, ISOMer, Faculté de Pharmacie de Nantes, 1 rue Gaston Veil, BP 92208, 44322 Nantes Cedex 03, France.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Moreau
authors.forename: Christophe
authors.initials: C
authors.lastname: Tomasoni
authors.forename: Catherine
authors.initials: C
authors.lastname: Jacquot
authors.forename: Raymond
authors.initials: R
authors.lastname: Kaas
authors.forename: Roland
authors.initials: R
authors.lastname: Le Guedes
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cadoret
authors.forename: Arnaud
authors.initials: A
authors.lastname: Muller-Feuga
authors.forename: Ioanna
authors.initials: I
authors.lastname: Kontiza
authors.forename: Constantinos
authors.initials: C
authors.lastname: Vagias
authors.forename: Vassilios
authors.initials: V
authors.lastname: Roussis
authors.forename: Christos
authors.initials: C
authors.lastname: Roussakis