title: [Biological dental implant: myth or reality?].
abstract: The currently available options for tooth-loss are prostheses, implants, or surgery (auto-transplantation). They all have their limitations. The emergence of tissue engineering, 15 years ago, was made possible by a better knowledge of the various stages of dental development, and the mastery of stem cell differentiation. It opened a new alternative approach for tooth regeneration. Even if animal experiments have demonstrated that it was possible to obtain a biological tooth from stem cells, two major issues remain to be discussed. Is it possible to use induced pluripotent stem cells instead of embryonic stem cells, which raise an ethical problem? Is it possible to reproduce a dental crown with an adapted shape and colour? Or should we consider the simpler creation of a biological root secondarily covered by a ceramic prosthesis? Our study mentions the main landmarks and the key cells involved in the embryological development of the tooth, establishes a mapping and a list of the various types of stem cells. It details the various methods used to create a biological implant.
authors.affiliation: Institut de génomique fonctionnelle de Lyon, « équipe physiopathologie de l'odontoblaste », UMR CNRS 5242, École normale supérieure de Lyon, 46, allée d'Italie, 69364 Lyon cedex 08, France. magloire@univ-lyon1.fr
authors.forename: H
authors.initials: H
authors.lastname: Magloire
authors.forename: M-L
authors.initials: ML
authors.lastname: Couble
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D003365:Costs and Cost Analysis; D003782:Dental Pulp / Q000166:cytology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D059630:Mesenchymal Stem Cells; D009805:Odontogenesis / Q000235:genetics; D012038:Regeneration; D013234:Stem Cells; D023822:Tissue Engineering; D014070:Tooth / Q000196:embryology* / Q000254:growth & development; D019228:Tooth Crown / Q000254:growth & development; D014083:Tooth Germ / Q000166:cytology; D014092:Tooth Root / Q000254:growth & development