title: Longitudinal changes of structural connectivity in traumatic axonal injury.
abstract: OBJECTIVE
  To identify structural connectivity change occurring during the first 6 months after traumatic brain injury and to evaluate the utility of diffusion tensor tractography for predicting long-term outcome.
  
  
  METHODS
  The participants were 28 patients with mild to severe traumatic axonal injury and 20 age- and sex-matched healthy control subjects. Neuroimaging was obtained 0-9 days postinjury for acute scans and 6-14 months postinjury for chronic scans. Long-term outcome was evaluated on the day of the chronic scan. Twenty-eight fiber regions of 9 major white matter structures were reconstructed, and reliable tractography measurements were determined and used.
  
  
  RESULTS
  Although most (23 of 28) patients had severe brain injury, their long-term outcome ranged from good recovery (16 patients) to moderately (5 patients) and severely disabled (7 patients). In concordance with the diverse outcome, the white matter change in patients was heterogeneous, ranging from improved structural connectivity, through no change, to deteriorated connectivity. At the group level, all 9 fiber tracts deteriorated significantly with 7 (corpus callosum, cingulum, angular bundle, cerebral peduncular fibers, uncinate fasciculus, and inferior longitudinal and fronto-occipital fasciculi) showing structural damage acutely and 2 (fornix body and left arcuate fasciculus) chronically. Importantly, the amount of change in tractography measurements correlated with patients' long-term outcome. Acute tractography measurements were able to predict patients' learning and memory performance; chronic measurements also determined performance on processing speed and executive function.
  
  
  CONCLUSIONS
  Diffusion tensor tractography is a valuable tool for identifying structural connectivity changes occurring between the acute and chronic stages of traumatic brain injury and for predicting patients' long-term outcome.
authors.affiliation: Department of Cognition and Neuroscience, University of Texas, Dallas, TX, USA.
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Bakhadirov
authors.forename: H
authors.initials: H
authors.lastname: Abdi
authors.forename: M D
authors.initials: MD
authors.lastname: Devous
authors.forename: C D
authors.initials: CD
authors.lastname: Marquez de la Plata
authors.forename: C
authors.initials: C
authors.lastname: Moore
authors.forename: C J
authors.initials: CJ
authors.lastname: Madden
authors.forename: R
authors.initials: R
authors.lastname: Diaz-Arrastia
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000473:pathology; D020833:Diffuse Axonal Injury / Q000209:etiology / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D055815:Young Adult