title: HIF-1α expression in the hippocampus and peripheral macrophages after glutamate-induced excitotoxicity.
abstract: Hypoxia-inducible factor-1 alpha (HIF-1α) is a master transcription factor that regulates the response to hypoxia and ischemia and induces the expression of various genes, including vascular endothelial growth factor (VEGF) and erythropoietin (EPO). This study shows the systemic response of increased HIF-1α, EPO, and VEGF mRNA and protein. In addition, VEGF expression was increased in neurons and over-expressed in glial cells in a model of neuroexcitotoxicity in the hippocampus, in which rats were neonatally exposed to high glutamate concentrations. Simultaneous increases in HIF-1α, EPO and VEGF mRNA in peritoneal macrophages were also observed. Our study is consistent with the hypothesis that these genes exert a protective effect in response to neurotoxicity.
authors.affiliation: Unidad de Investigación Médica en Epidemiología Clínica, UMAE, Hospital de Especialidades, CMNO, IMSS, Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Vazquez-Valls
authors.forename: M E
authors.initials: ME
authors.lastname: Flores-Soto
authors.forename: V
authors.initials: V
authors.lastname: Chaparro-Huerta
authors.forename: B M
authors.initials: BM
authors.lastname: Torres-Mendoza
authors.forename: G
authors.initials: G
authors.lastname: Gudiño-Cabrera
authors.forename: M C
authors.initials: MC
authors.lastname: Rivera-Cervantes
authors.forename: M
authors.initials: M
authors.lastname: Pallas
authors.forename: A
authors.initials: A
authors.lastname: Camins
authors.forename: J
authors.initials: J
authors.lastname: Armendáriz-Borunda
authors.forename: C
authors.initials: C
authors.lastname: Beas-Zarate
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D004921:Erythropoietin / Q000235:genetics / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D018698:Glutamic Acid / Q000633:toxicity; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000473:pathology*; D009498:Neurotoxins / Q000633:toxicity; D011247:Pregnancy; D012333:RNA, Messenger; D051381:Rats; D017208:Rats, Wistar; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009498:Neurotoxins; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D004921:Erythropoietin; D018698:Glutamic Acid