title: Promising targets and drugs in development for colorectal cancer.
abstract: Colorectal cancer (CRC) is one of the most common cancers and causes of cancer death in the world despite incremental improvement in the treatment of this disease. Advancements in the molecular understanding of CRC have led to new areas of therapeutic research. In this endeavor, numerous compounds with specific molecular targets are being developed in preclinical and early clinical studies. Molecular pathways involved in CRC and potentially effective targeted agents in development will be reviewed.
authors.affiliation: Division of Medical Oncology, University of Colorado at Denver, University of Colorado Cancer Center, Aurora, CO 80045, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Thompson
authors.forename: Stephen
authors.initials: S
authors.lastname: Leong
authors.forename: Wells
authors.initials: W
authors.lastname: Messersmith
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000379:methods; D055808:Drug Discovery / Q000379:methods; D015507:Drugs, Investigational / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D058990:Molecular Targeted Therapy
chemical_list: D000970:Antineoplastic Agents; D015507:Drugs, Investigational