title: Cerebrospinal fluid rhinorrhea: etiology, site of leakage and endoscopic management.
abstract: OBJECTIVE
  To determine the etiology and site of leak of cerebrospinal fluid (CSF) rhinorrhea and the surgical efficacy of Functional Endoscopic Sinus Surgery (FESS), in closing the defect of CSF leak by different graft materials.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Department of ENT-Head and Neck Surgery, Dow University of Health Sciences, Karachi, from September 2005 to December 2008.
  
  
  METHODS
  Clinical and pathological records of 23 patients who were diagnosed to have cerebrospinal fluid leak and managed by endoscopic approach were studied. Different graft materials alone or in combination were used endoscopically to seal the CSF leak. Results were obtained in terms of successful closure of the CSF leak, as evidenced by cessation of CSF rhinorrhea.
  
  
  RESULTS
  Iatrogenic trauma, due to previous surgery, was the commonest cause in (n=9, 39%) patients. Lateral lamella of cribriform plate (fovea ethmoidalis) was the commonest site of leak (n=10, 43.5%). The leak was closed solely by fat in 15 (65.2%) cases, combination of fat and middle turbinate mucosa (two layered) in 7 (30.4%) patients and temporalis fascia only in one patient (4.3%). Successful closure of the CSF leak in the first attempt was achieved in 22 (95.6%) patients.
  
  
  CONCLUSIONS
  Success rate achieved by endoscopic approach in this study was high. However, more data is required to prove the superiority of FESS over intracranial approach for management of CSF rhinorrhea.
authors.affiliation: Department of ENT Head and Neck Surgery, Dow University of Health Sciences, Karachi. umar_entsurgeon@yahoo.com
authors.forename: Muhammad Umar
authors.initials: MU
authors.lastname: Farooq
authors.forename: Murtaza Ahsan
authors.initials: MA
authors.lastname: Ansari
mesh_terms: D000293:Adolescent; D000328:Adult; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014420:Turbinates / Q000601:surgery; D055815:Young Adult