title: Impact of the NCAM derived mimetic peptide plannexin on the acute cellular consequences of a status epilepticus.
abstract: Plannexin represents a NCAM-derived peptide mimicking trans-homophilic NCAM interaction, which proved to exert neuroprotective effects in vitro. The effect of plannexin was evaluated in a rat status epilepticus model. As expected, prolonged seizure activity resulted in a pronounced cell loss in hippocampal subregions. The comparison between the vehicle- and plannexin-treated animals with status epilepticus did not reveal neuroprotective effects of plannexin on mature neurons. However, treatment with plannexin partially prevented the reduction in the number of doublecortin-labeled neuronal progenitor cells, which was evident 48h following status epilepticus. In conclusion, the data might give first evidence that plannexin can protect immature neurons in vivo. Future studies are necessary to evaluate whether disease-modifying or preventive effects are observed in models of epileptogenesis.
authors.affiliation: Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University, Koeniginstr. 16, D-80539 Munich, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Zellinger
authors.forename: Martin
authors.initials: M
authors.lastname: Hadamitzky
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Bock
authors.forename: Vladimir
authors.initials: V
authors.lastname: Berezin
authors.forename: Heidrun
authors.initials: H
authors.lastname: Potschka
mesh_terms: D000208:Acute Disease; D000818:Animals; D002450:Cell Communication / Q000187:drug effects / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D000089662:Doublecortin Protein; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects; D008024:Ligands; D018716:Molecular Mimicry / Q000502:physiology*; D009410:Nerve Degeneration / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D019006:Neural Cell Adhesion Molecules / Q000008:administration & dosage / Q000378:metabolism / Q000502:physiology*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000378:metabolism; D009842:Oligopeptides / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*
chemical_list: C000714848:Dcx protein, rat; D000089662:Doublecortin Protein; D008024:Ligands; D019006:Neural Cell Adhesion Molecules; D018696:Neuroprotective Agents; D009842:Oligopeptides; C553047:plannexin peptide