title: Novel interventional approaches for ALI/ARDS: cell-based gene therapy.
abstract: Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), continue to be a major cause of morbidity and mortality in critically ill patients. The present therapeutic strategies for ALI/ARDS including supportive care, pharmacological treatments, and ventilator support are still controversial. More scientists are focusing on therapies involving stem cells, which have self-renewing capabilities and differentiate into multiple cell lineages, and, genomics therapy which has the potential to upregulate expression of anti-inflammatory mediators. Recently, the combination of cell and gene therapy which has been demonstrated to provide additive benefit has opened up a new chapter in therapeutic strategy and provides a basis for the development of an innovative approach for the prevention and treatment of ALI/ARDS.
authors.affiliation: Department of Pulmonary Medicine, Huadong Hospital, Shanghai 200040, China.
authors.forename: Ying-Gang
authors.initials: YG
authors.lastname: Zhu
authors.forename: Jie-Ming
authors.initials: JM
authors.lastname: Qu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Hong-Ni
authors.initials: HN
authors.lastname: Jiang
authors.forename: Jin-Fu
authors.initials: JF
authors.lastname: Xu
mesh_terms: D055371:Acute Lung Injury / Q000401:mortality / Q000628:therapy*; D016638:Critical Illness / Q000401:mortality; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D012128:Respiratory Distress Syndrome / Q000401:mortality / Q000628:therapy*; D033581:Stem Cell Transplantation