title: [Hypoxaemia, peripheral chemoreceptors and fetal heart rate].
abstract: The perinatal results of the widespread adoption of the continuous electronic fetal heart rate monitoring during labor remain rather disappointing. This is due in part to a lack of consistent interpretation of the fetal heart tracings. Despite efforts by referral agencies over the past decade the situation has not improved. In defense of practitioners the heterogeneity and complexity of definitions and classifications patterns especially morphological currently proposed should be noted. Whereas with the recent advances in the field of neuroscience, it is now possible to visualize the chain of pathophysiological events that lead from the hypoxemic stimulus of the glomus cell to changes in the morphology of the fetal heart rate tracing. Thus by taking some examples of real situations, we propose a method of analysis that dissects the fetal heart tracing and take into account the functional specifications of the chemoreceptor when exposed to a hypoxic environment. Furthermore we can identify tracings with a "threshold effect" and also "sensitization and desensitization effects" according to the intensity, duration and recurrence of hypoxaemic episodes. This new approach based upon specific research into the mechanism behind the fetal heart rate abnormalities may be useful to complement the morphological study of the fetal heart tracing, to provide a better idea of the fetal status and to better define the indications of fetal blood sampling procedures.
authors.affiliation: Service d'obstétrique, pôle femme-mère-enfant, centre hospitalier de Côte Basque, 13, avenue de l'Interne-Jacques-Loëb, 64100 Bayonne, France. jfsecourgeon001@ch-cotebasque.fr
authors.forename: J-F
authors.initials: JF
authors.lastname: Secourgeon
mesh_terms: D000200:Action Potentials / Q000502:physiology; D001341:Autonomic Nervous System / Q000502:physiology; D002628:Chemoreceptor Cells / Q000502:physiology; D005260:Female; D005311:Fetal Hypoxia / Q000503:physiopathology*; D005323:Fetal Monitoring / Q000379:methods*; D005924:Glomus Jugulare / Q000503:physiopathology*; D006340:Heart Rate, Fetal / Q000502:physiology*; D006801:Humans; D007743:Labor, Obstetric; D008564:Membrane Potentials / Q000502:physiology; D011247:Pregnancy; D055366:Synaptic Potentials / Q000502:physiology