title: Chlamydia trachomatis and Mycoplasma genitalium plasma antibodies in relation to epithelial ovarian tumors.
abstract: OBJECTIVE
  To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors.
  
  
  METHODS
  Plasma samples from 291 women, undergoing surgery due to suspected ovarian pathology, were analyzed with respect to C. trachomatis IgG and IgA, chlamydial Heat Shock Protein 60-1 (cHSP60-1) IgG and M. genitalium IgG antibodies. Women with borderline tumors (n=12), ovarian carcinoma (n=45), or other pelvic malignancies (n=11) were matched to four healthy controls each.
  
  
  RESULTS
  Overall, there were no associations of antibodies with EOC. However, chlamydial HSP60-1 IgG antibodies were associated with type II ovarian cancer (P=.002) in women with plasma samples obtained >1 year prior to diagnosis (n=7). M. genitalium IgG antibodies were associated with borderline ovarian tumors (P=.01).
  
  
  CONCLUSIONS
  Chlamydial HSP60-1 IgG and M. genitalium IgG antibodies are in this study associated with epithelial ovarian tumors in some subsets, which support the hypothesis linking upper-genital tract infections and ovarian tumor development.
authors.affiliation: Department of Clinical Science/Obstetrics & Gynecology, Umeå University, SE-901 87 Umeå, Sweden. annika.idahl@obgyn.umu.se
authors.forename: Annika
authors.initials: A
authors.lastname: Idahl
authors.forename: Eva
authors.initials: E
authors.lastname: Lundin
authors.forename: Margaretha
authors.initials: M
authors.lastname: Jurstrand
authors.forename: Urban
authors.initials: U
authors.lastname: Kumlin
authors.forename: Fredrik
authors.initials: F
authors.lastname: Elgh
authors.forename: Nina
authors.initials: N
authors.lastname: Ohlson
authors.forename: Ulrika
authors.initials: U
authors.lastname: Ottander
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D018834:Chaperonin 60 / Q000097:blood; D002690:Chlamydia Infections / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008875:Middle Aged; D009175:Mycoplasma Infections / Q000276:immunology*; D045704:Mycoplasma genitalium / Q000276:immunology*; D009375:Neoplasms, Glandular and Epithelial / Q000276:immunology / Q000382:microbiology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000276:immunology / Q000382:microbiology* / Q000601:surgery
chemical_list: D000907:Antibodies, Bacterial; D018834:Chaperonin 60; D007074:Immunoglobulin G