title: Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.
abstract: Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(-8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10(-10), OR = 1.52, and DPB1*0901: P = 2.0×10(-7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.
authors.affiliation: Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Noguchi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Tomomitsu
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authors.lastname: Hirota
authors.forename: Kaori
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authors.lastname: Ochiai
authors.forename: Yoshimasa
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authors.forename: Masafumi
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authors.lastname: Sakashita
authors.forename: Fumitake
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authors.lastname: Kurosaka
authors.forename: Akira
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authors.forename: Shigemi
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authors.lastname: Yoshihara
authors.forename: Noriko
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authors.lastname: Kanno
authors.forename: Yumi
authors.initials: Y
authors.lastname: Yamada
authors.forename: Naoki
authors.initials: N
authors.lastname: Shimojo
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kohno
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Kang
authors.forename: Ji-Won
authors.initials: JW
authors.lastname: Kwon
authors.forename: Soo-Jong
authors.initials: SJ
authors.lastname: Hong
authors.forename: Ken
authors.initials: K
authors.lastname: Inoue
authors.forename: Yu-Ichi
authors.initials: Y
authors.lastname: Goto
authors.forename: Fumio
authors.initials: F
authors.lastname: Yamashita
authors.forename: Takashi
authors.initials: T
authors.lastname: Asada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirose
authors.forename: Ikuo
authors.initials: I
authors.lastname: Saito
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Fujieda
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hizawa
authors.forename: Toru
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Hironori
authors.initials: H
authors.lastname: Masuko
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nomura
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tamari
authors.forename: Tadao
authors.initials: T
authors.lastname: Arinami
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Yoshida
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Saito
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D000293:Adolescent; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006682:HLA-DP Antigens / Q000235:genetics*; D059867:HLA-DP alpha-Chains / Q000235:genetics; D059868:HLA-DP beta-Chains / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D006682:HLA-DP Antigens; D059867:HLA-DP alpha-Chains; D059868:HLA-DP beta-Chains; C071172:HLA-DPA1 antigen; C071170:HLA-DPB1 antigen