title: Fatal post-operative Trichoderma longibrachiatum mediastinitis and peritonitis in a paediatric patient with complex congenital cardiac disease on peritoneal dialysis.
abstract: Trichoderma longibrachiatum is an emerging pathogen in immunocompromised patients. We report a case of Trichoderma post-operative mediastinitis and peritonitis in a child with complex congenital cardiac disease and functional asplenia. The patient was treated unsuccessfully, initially with caspofungin alone followed by a combination of voriconazole (systemic and topical), caspofungin and intraperitoneal amphotericin B.
authors.affiliation: Department of Pediatric and Adolescent Medicine, Division of Pediatric Infectious Diseases, Mayo Clinic College of Medicine and Mayo Eugenio Litta Children's Hospital, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Santillan Salas
authors.affiliation: Department of Pediatric and Adult Allergy/Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
authors.forename: Avni Y
authors.initials: AY
authors.lastname: Joshi
authors.affiliation: Department of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
authors.forename: Neelam
authors.initials: N
authors.lastname: Dhiman
authors.affiliation: Department of Pediatric and Adolescent Medicine, Division of Pediatric Infectious Diseases, Mayo Clinic College of Medicine and Mayo Eugenio Litta Children's Hospital, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Ritu
authors.initials: R
authors.lastname: Banerjee
authors.affiliation: Department of Pediatric and Adolescent Medicine, Division of Pediatric Infectious Diseases, Mayo Clinic College of Medicine and Mayo Eugenio Litta Children's Hospital, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: W Charles
authors.initials: WC
authors.lastname: Huskins
authors.affiliation: Department of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Wengenack
authors.affiliation: Department of Pediatric and Adolescent Medicine, Division of Pediatric Infectious Diseases, Mayo Clinic College of Medicine and Mayo Eugenio Litta Children's Hospital, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Nancy K
authors.initials: NK
authors.lastname: Henry
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000077336:Caspofungin; D002675:Child, Preschool; D054714:Echinocandins / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000601:surgery*; D006801:Humans; D016867:Immunocompromised Host; D055666:Lipopeptides; D008480:Mediastinitis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D009181:Mycoses / Q000188:drug therapy; D010530:Peritoneal Dialysis; D010538:Peritonitis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D011183:Postoperative Complications; D011743:Pyrimidines / Q000627:therapeutic use; D013154:Spleen / Q000002:abnormalities; D014230:Triazoles / Q000627:therapeutic use; D014242:Trichoderma; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D000077336:Caspofungin; D065819:Voriconazole