title: Subcutaneous Ewing sarcoma/PNET as a second cancer in a previously irradiated young patient. an uncommon type of post-irradiation soft tissue sarcoma.
abstract: Soft tissue sarcomas account for a small proportion of second cancers, with an estimated frequency of < 10%. The most common histologic type of soft tissue sarcomas as second cancers include mostly high-grade sarcomas, such as rhabdomyosarcoma, malignant peripheral nerve sheath tumour, fibrosarcoma, leiomyosarcoma, synovial sarcoma, alveolar soft part sarcoma and Ewing sarcoma/primitive neuroectodermal tumour (PNET). We report a case of superficial soft tissue Ewing sarcoma/PNET as a second cancer in a young patient previously treated for Hodgkin's disease (HD). To the best of our knowledge and based on a literature search, this is the first reported case of post-irradiation soft tissue Ewing sarcoma/PNET as a second cancer arising in the same area irradiated for cure of HD.
authors.affiliation: Division Anatomic Pathology, Madonna delle Grazie Hospital, Matera, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bruno
authors.forename: G I
authors.initials: GI
authors.lastname: D'antona
authors.forename: G
authors.initials: G
authors.lastname: Vita
authors.forename: G
authors.initials: G
authors.lastname: Perrone
authors.forename: F
authors.initials: F
authors.lastname: Fiordelisi
authors.forename: M
authors.initials: M
authors.lastname: Bisceglia
mesh_terms: D000293:Adolescent; D003131:Combined Modality Therapy; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012512:Sarcoma, Ewing / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D040521:Subcutaneous Tissue / Q000473:pathology*; D016896:Treatment Outcome