title: Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis.
abstract: Tumor metastasis is a complex multistep process by which cells from the primary tumor invade tissues, move through the vasculature, settle at distant sites and eventually grow to form secondary tumors. Altered tyrosine phosphorylation signals in cancer cells contribute to a number of aberrant characteristics involved in tumor invasion and metastasis. CUB domain-containing protein 1 (CDCP1) is a substrate of Src family kinases and has been shown to regulate anoikis resistance, migration and matrix degradation during tumor invasion and metastasis in a tyrosine phosphorylation-dependent manner. Knockdown of CDCP1 blocks tumor metastasis or peritoneal dissemination in vivo, without significantly affecting cell proliferation. Moreover, expression levels of CDCP1 are of prognostic value in several cancers. Here, we summarize the studies on CDCP1, focusing on structure and signal transduction, to gain insight into its role in cancer progression. Understanding the signaling pathways regulated by CDCP1 could help establish novel therapeutic strategies against the progression of cancer.
authors.affiliation: Division of Metastasis and Invasion Signaling, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Uekita
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Sakai
mesh_terms: D000818:Animals; D023102:Anoikis / Q000187:drug effects / Q000502:physiology; D015703:Antigens, CD / Q000235:genetics / Q000502:physiology*; D000951:Antigens, Neoplasm / Q000502:physiology; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006031:Glycosylation / Q000187:drug effects; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D010766:Phosphorylation / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; C432044:CDCP1 protein, human; C529673:CDCP1 protein, mouse; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D047428:Protein Kinase Inhibitors