title: Synthesis of disaccharide fragments of the AT-III binding domain of heparin and their sulfonatomethyl analogues.
abstract: d-Glucuronate and l-iduronate-containing disaccharides related to the antithrombin-binding domain of heparin were prepared. The carboxylic function of the uronic acid unit was formed on a disaccharide level in the case of the glucuronate, while on a monosaccharide level in the case of the iduronate derivatives. Synthesis of their sulfonic acid analogues was carried out analoguosly applying sulfonatomethyl-containing acceptors in the form of either salts or methyl esters. Significant difference could be observed in the methyl ether formation reactions of the sulfonatomethyl-containing uronate disaccharides and the non-sulfonic acid uronates.
authors.affiliation: University of Debrecen, Debrecen, Hungary.
authors.forename: Mihály
authors.initials: M
authors.lastname: Herczeg
authors.forename: László
authors.initials: L
authors.lastname: Lázár
authors.forename: Attila
authors.initials: A
authors.lastname: Mándi
authors.forename: Anikó
authors.initials: A
authors.lastname: Borbás
authors.forename: István
authors.initials: I
authors.lastname: Komáromi
authors.forename: András
authors.initials: A
authors.lastname: Lipták
authors.forename: Sándor
authors.initials: S
authors.lastname: Antus
mesh_terms: D000990:Antithrombin III / Q000737:chemistry*; D002240:Carbohydrate Sequence; D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D006493:Heparin / Q000737:chemistry*; D007067:Iduronic Acid / Q000737:chemistry
chemical_list: D004187:Disaccharides; D007067:Iduronic Acid; D000990:Antithrombin III; D006493:Heparin