title: Genetic variations in tumor necrosis factor alpha, interleukin-10 genes, and migraine susceptibility.
abstract: OBJECTIVE
  Migraine is a very common headache disorder and pathogenesis of the disease is still largely unknown. Cytokine genes have been implicated in migraine susceptibility. The present study was designed to explore the associations of polymorphisms in the tumor necrosis factor alpha (TNF-α), interleukin-10 (IL-10) gene, and IL-10 haplotypes in Turkish migraine patients.
  
  
  METHODS
  TNF-α-308G/A, IL-10 -1082G/A, -819C/T, and -592C/A polymorphisms in 203 migraine patients and 202 healthy subjects were analyzed by using amplification refractory mutation system-polymerase chain reaction.
  
  
  RESULTS
  The -308G/A genotypic and -308A allelic frequency of TNF-α polymorphism was higher in migraine patients than healthy controls, and significant association was found between migraine and TNF-α-308G/A polymorphism (Bonferroni correction [Pc]: <0.0001, odds ratio: 2.16, 95% confidence interval: 1.44-3.28). No statistically significant association was found between IL-10 -1082G/A, -819C/T, and -592C/A polymorphisms and haplotypes containing these alleles and migraine.
  
  
  CONCLUSIONS
  This study reflect that TNF-α-308G/A polymorphism may be one of the many genetic factors for migraine susceptibility in the Turkish population.
authors.affiliation: Department of Medical Biology, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey. omerates27@yahoo.com
authors.forename: Omer
authors.initials: O
authors.lastname: Ates
authors.forename: Semiha
authors.initials: S
authors.lastname: Kurt
authors.forename: Julide
authors.initials: J
authors.lastname: Altinisik
authors.forename: Hatice
authors.initials: H
authors.lastname: Karaer
authors.forename: Saime
authors.initials: S
authors.lastname: Sezer
mesh_terms: D000328:Adult; D000483:Alleles; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10