title: Reproducibility of pulse wave velocity measurements with phase contrast magnetic resonance and applanation tonometry.
abstract: Increased aortic pulse wave velocity (PWV) results from loss of arterial compliance and is associated with unfavorable outcomes. Applanation tonometry (AT) is the most frequently applied method to assess PWV and deduce aortic compliance. The goal of this study was to compare the reproducibility of PWV measurements obtained with: (1) cross-correlation analysis of phase contrast magnetic resonance (PCMR) velocity data, and (2) applanation tonometry (AT). PWV was measured twice with each modality in 13 normal young volunteers (controls) and 9 older patients who had undergone a CT exam to evaluate coronary artery calcium. The coefficient of variation (CoV) between measurements was computed for each modality. There was no significant difference in PWV values obtained with AT and PCMR in controls or patients. The inter-scan reproducibility of PCMR was superior to AT in the controls (CoV: 3.4 ± 2.3% vs. 6.3 ± 4.0%, P = 0.03) but not in the older patients (7.4 ± 8.0% vs. 9.9 ± 9.6%, P = 0.32). PWV values were higher in patients than controls (5.6 ± 1.2 vs. 9.7 ± 2.8, P = 0.002). PCMR and AT yielded similar values for PWV in patients and volunteers. PCMR showed a superior reproducibility in young subjects but not in older patients.
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 1364 Cilfton Road, Suite AG30, Atlanta, GA 30322, USA. suever@gatech.edu
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Suever
authors.forename: John
authors.initials: J
authors.lastname: Oshinski
authors.forename: Enrique
authors.initials: E
authors.lastname: Rojas-Campos
authors.forename: David
authors.initials: D
authors.lastname: Huneycutt
authors.forename: Francesca
authors.initials: F
authors.lastname: Cardarelli
authors.forename: Arthur E
authors.initials: AE
authors.lastname: Stillman
authors.forename: Paolo
authors.initials: P
authors.lastname: Raggi
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001158:Arteries / Q000503:physiopathology*; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D003187:Compliance; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000503:physiopathology; D005845:Georgia; D006801:Humans; D008279:Magnetic Resonance Imaging; D008365:Manometry; D008875:Middle Aged; D011237:Predictive Value of Tests; D011673:Pulsatile Flow; D015203:Reproducibility of Results; D061205:Vascular Calcification / Q000175:diagnosis* / Q000503:physiopathology