title: [Effect of curcumin on expression of Abeta42 and Abeta-degrading enzyme NEP in APPswe/PS1dE9 double transgenic mice].
abstract: OBJECTIVE
  To observe the effect of curcumin on the expression of Abeta42 and its degrading enzyme NEP in APP/PS1 double transgenic mice.
  
  
  METHODS
  3-month old APP/PS1 dtg mice were randomly divided into model group, positive control group and curcumin large, medium and small dose group. After 3 months, Morris water maze, immunohistochemistry, Western blot were applied to detect learning and memory ability of animal.
  
  
  RESULTS
  Behavior detection, compared with the model group, treatment group showed varying degrees of difference in place navigation test and space exploration experiments (P < 0.01 or P < 0.05). The expression of Abeta42 and its degrading enzyme NEP, Abeta42-positive cells of hippocampus CA1 region significantly increased in model mice as compared with normal control group (P < 0.01).
  
  
  CONCLUSIONS
  Curcumin can improve learning and memory ability of APP/PS1 double transgenic mice through increasing the expression of Abeta-degrading enzyme NEP and decreasing the expression of Abeta42.
authors.affiliation: Department of Chinese Medicine Pharmacology, College of Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. pw_wang@163.com
authors.forename: Pengwen
authors.initials: P
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Ruisheng
authors.initials: R
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Ren
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Zhu
authors.forename: Haiyun
authors.initials: H
authors.lastname: Sun
authors.forename: Jinduo
authors.initials: J
authors.lastname: Yang
authors.forename: Jianning
authors.initials: J
authors.lastname: Sun
mesh_terms: D016229:Amyloid beta-Peptides / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000378:metabolism*; D003474:Curcumin / Q000494:pharmacology*; D012321:DNA-Directed RNA Polymerases / Q000187:drug effects / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010446:Peptide Fragments / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); C409038:nucleus-encoded phage-type RNA polymerase; D012321:DNA-Directed RNA Polymerases; D003474:Curcumin