title: An assessment of bone fluoride and osteosarcoma.
abstract: The association between fluoride and risk for osteosarcoma is controversial. The purpose of this study was to determine if bone fluoride levels are higher in individuals with osteosarcoma. Incident cases of osteosarcoma (N = 137) and tumor controls (N = 51) were identified by orthopedic physicians, and segments of tumor-adjacent bone and iliac crest bone were analyzed for fluoride content. Logistic regression adjusted for age and sex and potential confounders of osteosarcoma was used to estimate odds ratios (OR) and 95% confidence intervals (CI). There was no significant difference in bone fluoride levels between cases and controls. The OR adjusted for age, gender, and a history of broken bones was 1.33 (95% CI: 0.56-3.15). No significant association between bone fluoride levels and osteosarcoma risk was detected in our case-control study, based on controls with other tumor diagnoses.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
authors.forename: F M
authors.initials: FM
authors.lastname: Kim
authors.forename: C
authors.initials: C
authors.lastname: Hayes
authors.forename: P L
authors.initials: PL
authors.lastname: Williams
authors.forename: G M
authors.initials: GM
authors.lastname: Whitford
authors.forename: K J
authors.initials: KJ
authors.lastname: Joshipura
authors.forename: R N
authors.initials: RN
authors.lastname: Hoover
authors.forename: C W
authors.initials: CW
authors.lastname: Douglass
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000737:chemistry*; D001842:Bone and Bones / Q000737:chemistry*; D016022:Case-Control Studies; D002648:Child; D016001:Confidence Intervals; D005260:Female; D005459:Fluorides / Q000032:analysis*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012516:Osteosarcoma / Q000737:chemistry*; D012307:Risk Factors; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D005459:Fluorides