title: [Investigation of the intramolecular cyclization of the thiophene substituted cyclohexane skeleton gamma-oxocarboxylic acid and synthesis of some N-heteroaryl isoindole derivatives].
abstract: From thiophene and cis-hexahydrophthalic anhydride the corresponding gamma-oxocarboxylic acid was obtained by the Friedel-Crafts reaction, which resulted in new heterocycles with acetic anhydride, Lawesson reagent or urea by intramolecular cyclization. Saturated N-heteroaryl isoindoles were prepared directly by the fusion reaction of heteroaromatic amines with the oxocarboxylic acid.
authors.affiliation: Kabay Jdnos Gyógyszertár, 4080 Hajdúnánás, Bocskai u. 22. csende@nanaskabel.hu
authors.forename: Ferenc
authors.initials: F
authors.lastname: Csende
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D003500:Cyclization; D003510:Cyclohexanes / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007536:Isomerism; D015394:Molecular Structure; D013876:Thiophenes
chemical_list: D002264:Carboxylic Acids; D003510:Cyclohexanes; D007211:Indoles; D013876:Thiophenes; C506365:Cyclohexane