title: The dosages of corticosteroid in transforaminal epidural steroid injections for lumbar radicular pain due to a herniated disc.
abstract: BACKGROUND
  Intervertebral disc herniations are the most common cause of lumbosacral radiculopathy, and transforaminal epidural steroid injection (TFESI) is an important tool in treating lumbosacral radiculopathy. But the ideal dose of corticosteroid in the epidural management of lumbosacral radiculopathy has yet to be determined.
  
  
  OBJECTIVE
  The aim of this study was to determine the effective dose of steroids in TFESI for pain reduction in patients with lumbosacral radiculopathy.
  
  
  METHODS
  A randomized, double blind, controlled trial.
  
  
  METHODS
  An interventional pain management practice center.
  
  
  METHODS
  A total of 160 participants received 2 epidural injections of either 5 mg, 10 mg, 20 mg, or 40 mg of triamcinolone in one week intervals via TFESI. The degree of participant satisfaction and verbal numerical rating scale (VNRS) were assessed at pretreatment, one week, and 2 weeks after the first TFESI.
  
  
  RESULTS
  The number of participants experiencing pain relief was significantly less than in other groups in the 5 mg triamcinolone group at one week after the first TFESI. There were no significant differences among the groups at one week after the second TFESI. VNRS decreased in the other groups except the triamcinolone 5 mg group at one week after the first TFESI. VNRS decreased in all groups at one week after the second TFESI.
  
  
  CONCLUSIONS
  The limitations include lack of placebo control group and lack of long-term follow-up.
  
  
  CONCLUSIONS
  We recommend a minimal effective dose of corticosteroid (triamcinolone 10 mg) in TFESI for patients with lumbosacral radiculopathy.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Institute of Medical Sciences, Kangwon National University Hospital, School of Medicine, Chuncheon, South Korea.
authors.forename: Seong-Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Byeong-Mun
authors.initials: BM
authors.lastname: Hwang
authors.forename: Hee-Jeong
authors.initials: HJ
authors.lastname: Son
authors.forename: Il-Young
authors.initials: IY
authors.lastname: Cheong
authors.forename: Sang-Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Lee
authors.forename: Tae-Yoon
authors.initials: TY
authors.lastname: Chung
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007268:Injections, Epidural / Q000379:methods*; D007405:Intervertebral Disc Displacement / Q000150:complications*; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D011843:Radiculopathy; D014221:Triamcinolone / Q000008:administration & dosage*
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D014221:Triamcinolone