title: Curcumin derivatives as new ligands of Aβ peptides.
abstract: Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been synthesized in a straightforward manner. All compounds retained Curcumin ability to bind Aβ peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently Aβ deposits.
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, Milan, Italy. cristina.airoldi@unimib.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Airoldi
authors.forename: Cristiano
authors.initials: C
authors.lastname: Zona
authors.forename: Erika
authors.initials: E
authors.lastname: Sironi
authors.forename: Laura
authors.initials: L
authors.lastname: Colombo
authors.forename: Massimo
authors.initials: M
authors.lastname: Messa
authors.forename: Dario
authors.initials: D
authors.lastname: Aurilia
authors.forename: Maria
authors.initials: M
authors.lastname: Gregori
authors.forename: Massimo
authors.initials: M
authors.lastname: Masserini
authors.forename: Mario
authors.initials: M
authors.lastname: Salmona
authors.forename: Francesco
authors.initials: F
authors.lastname: Nicotra
authors.forename: Barbara
authors.initials: B
authors.lastname: La Ferla
mesh_terms: D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D056004:Molecular Dynamics Simulation; D019906:Nuclear Magnetic Resonance, Biomolecular; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D012995:Solubility
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D003474:Curcumin