title: [Possibilities of using interferon-induction therapy during latent HBV infection].
abstract: The article is devoted to the problem of latent hepatitis B virus (HBV) infection, the aspects of etiology, and questions of diagnostics and directions of treatment optimization. Immune violations, developing on the background of disfunction of mononuclear phagocytes of liver and chronic inflammation in a hepatic parenchyma with the elements of autoalteration by immune factors, and their role in latent HBV infection are described. Possibilities of using laboratory (including immunological and immunohistochemical) methods of diagnostics are considered.
authors.forename: V V
authors.initials: VV
authors.lastname: Stel'makh
mesh_terms: D000166:Acridines / Q000008:administration & dosage*; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D001707:Biopsy, Needle; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007167:Immunotherapy / Q000379:methods; D007369:Interferon Inducers / Q000008:administration & dosage; D007370:Interferon Type I / Q000008:administration & dosage; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D008099:Liver / Q000187:drug effects / Q000276:immunology* / Q000821:virology; D008297:Male; D010586:Phagocytes / Q000187:drug effects* / Q000276:immunology; D011994:Recombinant Proteins; D017735:Virus Latency / Q000276:immunology
chemical_list: D000166:Acridines; D000998:Antiviral Agents; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D007369:Interferon Inducers; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; C026430:10-carboxymethyl-9-acridanone