title: Role of micronutrients against dimethylmercury intoxication in male rats.
abstract: Mercury is one of the most toxic non-radioactive heavy metals. Chelation therapy has been the basis for the medical treatment of mercury poisoning. Male albino rats were administered dimethylmercury (1.5mg/kg) orally for 21 days. Chelation therapy with N-acetyl cysteine along with combination of antioxidants viz. zinc and selenium was given for 5 days after 24h of toxicant administration. All animals were sacrificed after 48h of last treatment and various blood biochemical parameters were performed. Toxicant caused rise in bilirubin, γ-GT, cholesterol, triglycerides, urea, creatinine, the uric acid content with a decline in albumin. A significant elevation was observed in LPO content and mercury concentration, along with concomitant decline in GSH levels after toxicant administration in liver, kidney and brain. Noticeable fall was also observed in AChE enzyme. Histopathological analysis was consistent with the biochemical observations and led to conclude that combination therapy provided protection against mercury toxicity.
authors.affiliation: Reproductive Biology and Toxicology Laboratory, UNESCO Satellite center of Trace Element Research & School of Studies in Zoology, Jiwaji University, Gwalior, (M.P.) 474011, India.
authors.forename: Deepmala
authors.initials: D
authors.lastname: Joshi
authors.forename: Deepak Kumar
authors.initials: DK
authors.lastname: Mittal
authors.forename: Monika
authors.initials: M
authors.lastname: Bhadauria
authors.forename: Satendra Kumar
authors.initials: SK
authors.lastname: Nirala
authors.forename: Sadhana
authors.initials: S
authors.lastname: Shrivastava
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Shukla