title: Decreased plasma levels of ceruloplasmin after diet-induced weight loss in obese women.
abstract: BACKGROUND
  Plasma ceruloplasmin (Cp) has been shown to be a risk factor for cardiovascular disease and also to be associated with obesity. However, it is not known whether weight loss could decrease the plasma Cp levels.
  
  
  OBJECTIVE
  To investigate the effect of diet-induced weight loss on plasma Cp in obese women.
  
  
  METHODS
  Sixty-seven healthy obese women [age =33.4±8.7 yr, body mass index (BMI) =36.0±4.8 kg/m2] were entered into a medically supervised program aimed at reducing body weight by 10% or more. Weight loss was achieved through a diet providing a daily energy deficit of 500-1000 kcal/day. In addition, all patients were prescribed to use 50 g of a fiber supplement per day. For all subjects, assessment of dietary intake, anthropometric indices, and plasma levels of C-reactive protein and Cp was performed at the first visit and repeated at 12th week of follow-up.
  
  
  RESULTS
  By completing the program, weight (Δ=-9.5%, p<0.0001), BMI (Δ=-9.7%, p<0.0001), waist-circumference (Δ=-6.1%, p<0.0001), and triceps skinfold thickness (Δ=-14.9%, p<0.0001) significantly decreased. Plasma Cp significantly decreased after 12 weeks of dietary intervention (33.6±5.6 mg/dl vs 25.2±5.8 mg/dl, p<0.0001). Percent change in Cp was correlated with percent change in waist-circumference (r=446, p=0.015).
  
  
  CONCLUSIONS
  Our study suggests that an improved body composition induced by restriction of energy intake is associated with decreased serum concentrations of Cp in obese women which in turn might have reduced the subjects' risk of developing cardiovascular disease.
authors.affiliation: Nutrition and Biochemistry Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Tajik
authors.forename: A
authors.initials: A
authors.lastname: Golpaie
authors.forename: S A
authors.initials: SA
authors.lastname: Keshavarz
authors.forename: M
authors.initials: M
authors.lastname: Djalali
authors.forename: M
authors.initials: M
authors.lastname: Sehat
authors.forename: F
authors.initials: F
authors.lastname: Masoudkabir
authors.forename: Z
authors.initials: Z
authors.lastname: Ahmadivand
authors.forename: F
authors.initials: F
authors.lastname: Fatehi
authors.forename: M
authors.initials: M
authors.lastname: Zare
authors.forename: T
authors.initials: T
authors.lastname: Yazdani
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism*; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D006801:Humans; D009765:Obesity / Q000097:blood* / Q000178:diet therapy*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D002097:C-Reactive Protein; D002570:Ceruloplasmin