title: Lamins, laminopathies and disease mechanisms: possible role for proteasomal degradation of key regulatory proteins.
abstract: Lamins are major structural proteins of the nucleus and are essential for nuclear integrity and organization of nuclear functions. Mutations in the human lamin genes lead to highly degenerative genetic diseases that affect a number of different tissues such as muscle, adipose or neuronal tissues, or cause premature ageing syndromes. New findings on the role of lamins in cellular signalling pathways, as well as in ubiquitin-mediated proteasomal degradation, have given important insights into possible mechanisms of pathogenesis.
authors.affiliation: Centre for Cellular and Molecular Biology (CSIR), Hyderabad 500 007, India. veenap@ccmb.res.in
authors.forename: Veena K
authors.initials: VK
authors.lastname: Parnaik
authors.forename: Pankaj
authors.initials: P
authors.lastname: Chaturvedi
authors.forename: B
authors.initials: B
authors.lastname: Muralikrishna
mesh_terms: D030342:Genetic Diseases, Inborn / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D034882:Lamins / Q000235:genetics / Q000378:metabolism*; D020125:Mutation, Missense; D034881:Nuclear Lamina / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D034882:Lamins; D046988:Proteasome Endopeptidase Complex