title: Detection of HIV-1 viruses in tears of patients even under long-term HAART.
abstract: To determine whether HIV-1 viruses exist in tears of patients under HAART, a cross-sectional study was designed. All participants who underwent long-term HAART with undetectable plasma viral load had detectable HIV-1 viral load in tears (n = 16) and had no difference from the controls (n = 5). Our data suggested that the lacrimal gland and/or other tear-associated tissues could be new reservoirs for HIV-1 and precautions should be taken when doing eye examinations.
authors.affiliation: Department of Infectious Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.forename: Ning
authors.initials: N
authors.lastname: Wu
authors.forename: Weijun
authors.initials: W
authors.lastname: Zhu
authors.forename: Yanling
authors.initials: Y
authors.lastname: Li
authors.forename: Lingyan
authors.initials: L
authors.lastname: Zuo
authors.forename: Junjie
authors.initials: J
authors.lastname: Ye
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Qiu
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.forename: Taisheng
authors.initials: T
authors.lastname: Li
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000378:metabolism* / Q000821:virology; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013666:Tears / Q000378:metabolism* / Q000821:virology*; D019562:Viral Load
chemical_list: D012367:RNA, Viral