title: It is not about the bike, it is about the pedaling: forced exercise and Parkinson's disease.
abstract: Forced exercise has resulted in neuroprotective effects and improved motor function in animal studies. These promising results have not yet been translated fully to humans with Parkinson's disease (PD), as traditional exercise interventions have not yielded global improvements in function. A novel forced exercise intervention is described that has resulted in improved motor function and central nervous system function in PD patients.
authors.affiliation: Department of Biomedical Engineering, Center for Neurological Restoration, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA. albertj@ccf.org
authors.forename: Jay L
authors.initials: JL
authors.lastname: Alberts
authors.forename: Susan M
authors.initials: SM
authors.lastname: Linder
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Penko
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Lowe
authors.forename: Micheal
authors.initials: M
authors.lastname: Phillips
mesh_terms: D000818:Animals; D001642:Bicycling; D015444:Exercise; D005081:Exercise Therapy; D006801:Humans; D009473:Neuronal Plasticity; D010300:Parkinson Disease / Q000628:therapy*