title: [Modification of infrastructure of Candida albicans under the influence of associative microbiota exometabolites].
abstract: OBJECTIVE
  Evaluation of the influence of bacterial microbiota exometabolites on temporal organization of biological features of Candida albicans. MATERIALS AND METHODS; Experiments were carried out on the model of C. albicans 24433 ATCC for 24 hours with 4 hour intervals. Biorythms of proliferative, phospholipase and adhesive activity of fungi were studied. Influence of exometabolites of Staphylococcus aureus 25923 ATCC, Escherichia coli 35218 ATCC, Pseudomonas aeruginosa 27853 ATCC on biological properties of C. albicans were examined. The results were statistically analyzed by using Student's t-test.
  
  
  RESULTS
  Circadian biological rhythms were detected for all investigated parameters of C. albicans 24433 ATCC. In the presence of exometabolites of S. aureus and P. aeruginosa, rhythm profile and amplitude oscillation of the fungi changes, and phase synchronism is disrupted. Under the influence of exometabolites of Gram-negative microbiota a marked desynchrony of fungi adhesive activity was observed.
  
  
  CONCLUSIONS
  The results obtained confirm the key role of microorganisms in the formation and regulation of pathogenic microsymbiocenosis, and determine the necessity to study mechanisms of symbiotic interaction of bacteria and fungi.
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Timokhina
authors.forename: M V
authors.initials: MV
authors.lastname: Nikolenko
authors.forename: V V
authors.initials: VV
authors.lastname: Varnitsina
authors.forename: N B
authors.initials: NB
authors.lastname: Perunova
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
mesh_terms: D002176:Candida albicans / Q000201:enzymology / Q000472:pathogenicity*; D002448:Cell Adhesion; D002940:Circadian Rhythm; D004926:Escherichia coli / Q000378:metabolism*; D054892:Metagenome; D010740:Phospholipases / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000378:metabolism*; D013559:Symbiosis
chemical_list: D010740:Phospholipases