title: The mitochondrial citrate carrier: a new player in inflammation.
abstract: The mitochondrial CIC (citrate carrier) catalyses the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. In the present paper we show that CIC mRNA and protein markedly increase in lipopolysaccharide-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of NO, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation.
authors.affiliation: Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy.
authors.forename: Vittoria
authors.initials: V
authors.lastname: Infantino
authors.forename: Paolo
authors.initials: P
authors.lastname: Convertini
authors.forename: Liana
authors.initials: L
authors.lastname: Cucci
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Panaro
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Di Noia
authors.forename: Rosa
authors.initials: R
authors.lastname: Calvello
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Palmieri
authors.forename: Vito
authors.initials: V
authors.lastname: Iacobazzi
mesh_terms: D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism; D020868:Gene Silencing; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D002352:Carrier Proteins; D018836:Inflammation Mediators; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; C020723:citrate-binding transport protein; D009569:Nitric Oxide