title: Lymphoepithelial-like carcinoma of the uterine cervix; a case report.
abstract: Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare variant of squamous cell carcinoma of the uterine cervix. This tumor is characterized by nests of poorly differentiated epithelial cells surrounded by a prominent lymphocytic infiltration. Despite the poorly differentiated pathological findings, it appears to have a better outcome than the usual squamous cell carcinoma of the uterine cervix. Therefore, it is quite important to differentiate this tumor from poorly differentiated squamous cell carcinoma and lympho-proliferative disorders of the cervix. LELC arising from the nasopharynx has been suggested to be associated with Epstein-Barr virus (EBV), whereas the involvement of EBV in LELC of the uterine cervix is still controversial. In addition, the role of high-risk human papilloma virus (HPV) in this type of tumor remains unknown. We report a case of LELC of the cervix with diagnosis on the basis of histopathology in a 52-year-old Japanese woman who presented with a history of continuous bleeding post menopause. We also examine the association of EBV and HPV in this case.
authors.affiliation: Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan. moriman@koto.kpu-m.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Sawada
authors.forename: S
authors.initials: S
authors.lastname: Matsuo
authors.forename: H
authors.initials: H
authors.lastname: Kuroboshi
authors.forename: H
authors.initials: H
authors.lastname: Tatsumi
authors.forename: K
authors.initials: K
authors.lastname: Iwasaku
authors.forename: J
authors.initials: J
authors.lastname: Kitawaki
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology* / Q000821:virology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000821:virology