title: A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge.
abstract: A concise method for the formation of cyclopyrophosphate of cIDPRE as well as sulfur and selenium-substituted pyrophosphate cIDPRE analogues (P(1)(S)-cIDPRE, P(1)(Se)-cIDPRE, P(2)(S)-cIDPRE and P(2)(Se)-cIDPRE) was reported and one of the P(S)-diastereoisomers, P(1)(S)-cIDPRE-1, is a novel membrane-permeant cADPR antagonist.
authors.affiliation: State Key Laboratory of Natural & Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors.forename: N
authors.initials: N
authors.lastname: Qi
authors.forename: K
authors.initials: K
authors.lastname: Jung
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: L X
authors.initials: LX
authors.lastname: Na
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Yang
authors.forename: L R
authors.initials: LR
authors.lastname: Zhang
authors.forename: A H
authors.initials: AH
authors.lastname: Guse
authors.forename: L H
authors.initials: LH
authors.lastname: Zhang
mesh_terms: D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000737:chemistry; D036563:Cyclic ADP-Ribose / Q000031:analogs & derivatives*; D011756:Diphosphates / Q000737:chemistry*; D007291:Inosine Monophosphate / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D008968:Molecular Conformation; D019837:Ryanodine Receptor Calcium Release Channel / Q000737:chemistry / Q000378:metabolism; D012643:Selenium / Q000737:chemistry; D013237:Stereoisomerism; D013455:Sulfur / Q000737:chemistry
chemical_list: D002121:Calcium Channel Blockers; D011756:Diphosphates; C494342:N(1)-((5''-O-phosphorylethoxy)methyl)-5'-O-phosphorylinosine 5',5''-cyclic pyrophosphate; D019837:Ryanodine Receptor Calcium Release Channel; D036563:Cyclic ADP-Ribose; D007291:Inosine Monophosphate; D013455:Sulfur; D012643:Selenium