title: Platelet-derived growth factor receptor (PDGFR) expression in primary spinal cord gliomas.
abstract: Abnormal signaling through the platelet-derived growth factor receptor (PDGFR) has been proposed as a possible mechanism of spinal cord glioma initiation and progression. However, the extent of PDGFR expression in human spinal cord gliomas remains unknown. In this study we perform immunohistochemical analysis of PDGFRα expression in a series of 33 primary intramedullary spinal cord gliomas of different types and grades. PDGFRα was seen to be expressed in a significant subset of these tumors across all major glioma types including ependymoma, oligodendroglioma, pilocytic astrocytoma, astrocytoma, and glioblastoma. These results support the hypothesis that growth factor signaling through the PDGFR may be important for the development of at least a subset of human spinal cord gliomas. Further studies investigating the prognostic significance of PDGFR expression as well as the role of PDGF signaling on the development of intramedullary spinal cord gliomas are warranted.
authors.affiliation: Department of Neurological Surgery, Neurological Institute of New York, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA. jae2109@columbia.edu
authors.forename: Jason A
authors.initials: JA
authors.lastname: Ellis
authors.forename: Peter
authors.initials: P
authors.lastname: Canoll
authors.forename: Paul C
authors.initials: PC
authors.lastname: McCormick
authors.forename: Neil A
authors.initials: NA
authors.lastname: Feldstein
authors.forename: Richard C
authors.initials: RC
authors.lastname: Anderson
authors.forename: Peter D
authors.initials: PD
authors.lastname: Angevine
authors.forename: Michael G
authors.initials: MG
authors.lastname: Kaiser
authors.forename: Paul C
authors.initials: PC
authors.lastname: McCormick
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Bruce
authors.forename: Alfred T
authors.initials: AT
authors.lastname: Ogden
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D017479:Receptors, Platelet-Derived Growth Factor / Q000096:biosynthesis*; D015398:Signal Transduction / Q000502:physiology; D013120:Spinal Cord Neoplasms / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
chemical_list: D017479:Receptors, Platelet-Derived Growth Factor