title: The multifaceted mosquito anti-Plasmodium response.
abstract: Plasmodium development within its mosquito vector is an essential step in malaria transmission, as illustrated in world regions where malaria was successfully eradicated via vector control. The innate immune system of most mosquitoes is able to completely clear a Plasmodium infection, preventing parasite transmission to humans. Understanding the biological basis of this phenomenon is expected to inspire new strategies to curb malaria incidence in countries where vector control via insecticides is unpractical, or inefficient because insecticide resistance genes have spread across mosquito populations. Several aspects of mosquito biology that condition the success of the parasite in colonizing its vector begin to be understood at the molecular level, and a wealth of recently published data highlights the multifaceted nature of the mosquito response against parasite invasion. In this brief review, we attempt to provide an integrated view of the challenges faced by the parasite to successfully invade its mosquito host, and discuss the possible intervention strategies that could exploit this knowledge for the fight against human malaria.
authors.affiliation: INSERM U963, CNRS UPR9022, 15 rue René Descartes, 67084 Strasbourg, Cedex, France. E.Marois@unistra.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Marois
mesh_terms: D000818:Animals; D009033:Culicidae / Q000235:genetics / Q000276:immunology / Q000469:parasitology*; D017344:Genes, Insect; D006458:Hemolymph / Q000276:immunology / Q000469:parasitology; D006790:Host-Parasite Interactions; D019476:Insect Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007303:Insect Vectors / Q000276:immunology / Q000469:parasitology; D008288:Malaria / Q000276:immunology / Q000469:parasitology* / Q000517:prevention & control; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D010961:Plasmodium / Q000276:immunology / Q000472:pathogenicity*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D019476:Insect Proteins; C540280:LRIM1 protein, Anopheles gambiae; D017382:Reactive Oxygen Species; C544265:TEP1 protein, Anopheles gambiae; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase