title: [Musculoskeletal manifestations in allogenic hematopoietic stem cell transplantation].
abstract: BACKGROUND
  Few studies have examined musculoskeletal manifestations after allogenic hematopoietic stem cell transplantation (AHSCT).
  
  
  OBJECTIVE
  To investigate the musculoskeletal symptoms observed after AHSCT for distinct hematological and non-hematological diseases.
  
  
  METHODS
  We performed a retrospective, observational study through review of medical records.
  
  
  RESULTS
  There were 123 patients who underwent AHSCT from 1996 to 2000: 34 children (aged 5 months-14 years) and 81 adults (aged 15-55 years). There were 48 women (39%) and 75 men (61%). Of these patients, 43 (34.90%) had acute graft-versus-host disease (aGVHD). Thirty-three out of 106 patients (31.1%) had chronic GVHD (cGVDH) and 50 patients (40.65%) died during follow-up. Musculoskeletal manifestations were found in 14 patients (13.2%): aseptic necrosis in six (5.6%), scleroderma in five (4.7%), arthralgia and bronchiolitis obliterans in one, polyarthralgia in one, and knee monoarthritis in one.
  
  
  CONCLUSIONS
  Musculoskeletal manifestations after AHSCT cannot be attributed to a single cause. Inflammatory and fibrosing manifestations can be due to the inflammatory process of cGVHD or to the treatments administered during transplantation.
authors.affiliation: Sección de Reumatología. Servicio de Hematología. Hospitales Universitarios Virgen del Rocío. Sevilla. España.
authors.forename: A
authors.initials: A
authors.lastname: García-López
authors.forename: C
authors.initials: C
authors.lastname: Fernández-Delgado
authors.forename: R
authors.initials: R
authors.lastname: Hernández-Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Uceda
authors.forename: R
authors.initials: R
authors.lastname: Parody