title: Physical exercise reverses cognitive impairment in rats subjected to experimental hyperprolinemia.
abstract: This study investigated whether physical exercise would reverse proline-induced performance deficits in water maze tasks, as well as its effects on brain-derived neurotrophic factor (BDNF) immunocontent and brain acetylcholinesterase (AChE) activity in Wistar rats. Proline administration followed partial time (6th-29th day of life) or full time (6th-60th day of life) protocols. Treadmill exercise was performed from 30th to 60th day of life, when behavioral testing was started. After that, animals were sacrificed for BDNF and AChE determination. Results show that proline impairs cognitive performance, decreases BDNF in cerebral cortex and hippocampus and increases AChE activity in hippocampus. All reported effects were prevented by exercise. These results suggest that cognitive, spatial learning/memory, deficits caused by hyperprolinemia may be associated, at least in part, to the decrease in BDNF levels and to the increase in AChE activity, as well as support the role of physical exercise as a potential neuroprotective strategy.
authors.affiliation: Laboratório de Neuroproteção e Doença Metabólica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, Porto Alegre, RS, Brazil.
authors.forename: Andréa G K
authors.initials: AG
authors.lastname: Ferreira
authors.forename: Emilene B
authors.initials: EB
authors.lastname: Scherer
authors.forename: Maira J
authors.initials: MJ
authors.lastname: da Cunha
authors.forename: Fernanda R
authors.initials: FR
authors.lastname: Machado
authors.forename: Aline A da
authors.initials: AA
authors.lastname: Cunha
authors.forename: Jeferson S
authors.initials: JS
authors.lastname: Graeff
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Netto
authors.forename: Angela T S
authors.initials: AT
authors.lastname: Wyse
mesh_terms: D050842:1-Pyrroline-5-Carboxylate Dehydrogenase / Q000172:deficiency; D000110:Acetylcholinesterase / Q000378:metabolism; D000592:Amino Acid Metabolism, Inborn Errors / Q000503:physiopathology* / Q000523:psychology; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003072:Cognition Disorders / Q000628:therapy*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D010805:Physical Conditioning, Animal; D011394:Proline Oxidase / Q000172:deficiency; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D050842:1-Pyrroline-5-Carboxylate Dehydrogenase; D011394:Proline Oxidase; D000110:Acetylcholinesterase