title: Effects of Ligustrum delavayanum Hariot. on cholesterol levels and arrhythmogenesis induced by myocardial ischaemia-reperfusion injury in diabetic-hypercholesterolaemic rats.
abstract: The present study was conducted to determine the effects of Ligustrum delavayanum Hariot. (Oleaceae) on cholesterol levels and the outcome of myocardial reperfusion injury in diabetic-hypercholesterolaemic rats. Per orally daily administration of a Ligustrum infusion (1000mg/kg, calculated on the dry plant material) to the rats with induced diabetes and hypercholesterolaemia significantly reduced the liver total cholesterol content. Similarly, increased severity of reperfusion arrhythmias in the double-diseased rats was diminished upon Ligustrum-treatment. These results suggest a potential use of Ligustrum in the prevention/therapy of risk factors and coronary heart disease itself.
authors.affiliation: Department of Pharmacology and Toxicology Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic.
authors.forename: Adriana
authors.initials: A
authors.lastname: Adameová
authors.forename: Mučaji
authors.initials: M
authors.lastname: Pavol
authors.forename: Svec
authors.initials: S
authors.lastname: Pavel
authors.forename: Nagy
authors.initials: N
authors.lastname: Milan
authors.forename: Faberová
authors.initials: F
authors.lastname: Viera
authors.forename: Kuželová
authors.initials: K
authors.lastname: Magdaléna