title: The complex world of kidney microRNAs.
abstract: MicroRNAs are short noncoding RNAs that usually reduce translation of messenger RNAs. Changes in microRNA-192 (miR-192) are reported in states of renal fibrosis. New evidence supports a role for miR-192 and its target miR-200b/c in transforming growth factor-β1 regulation of its own expression and that of collagens in mesangial cells, with a possible role in diabetic nephropathy. As there is controversy on the role of these microRNAs in diabetic nephropathy, more work is needed.
authors.affiliation: Department of Medicine, University of Texas Health Science Center, South Texas Veterans Health Care System, San Antonio, Texas 78229, USA. Kasinath@uthscsa.edu
authors.forename: Balakuntalam S
authors.initials: BS
authors.lastname: Kasinath
authors.forename: Denis
authors.initials: D
authors.lastname: Feliers
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000378:metabolism*; D050527:Mesangial Cells / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; C508961:Tgfb1 protein, mouse; D053773:Transforming Growth Factor beta1