title: [Neurological disorders associated with gluten sensitivity].
abstract: Gluten sensitivity is a systemic autoimmune disease that occurs in genetically susceptible individuals on ingesting gluten. It can appear at any age, then becoming a permanent condition. It is more frequent in women, as happens with other autoimmune diseases. Celiac disease is the intestinal form and the most important manifestation among a set of gluten-induced autoimmune pathologies that affect different systems. Neurological manifestations of gluten sensitivity, with or without enteropathy, are also frequent, their pathogenesis including an immunological attack on the central and peripheral nervous tissue accompanied by neurodegenerative changes. The clinical manifestations are varied, but the most common syndromes are cerebellar ataxia and peripheral neuropathy. Finally, gluten sensitivity is associated to a varying degree, with other complex diseases and could influence their evolution. The early detection of cases of gluten sensitivity with neurological manifestations and subsequent treatment with the gluten-free diet could provide remarkable benefits to the patients.
authors.affiliation: Hospital Universitario Central de Asturias, 33006 Oviedo, Espana. carloshlahoz@gmail.com
authors.forename: C
authors.initials: C
authors.lastname: Hernandez-Lahoz
authors.forename: G
authors.initials: G
authors.lastname: Mauri-Capdevila
authors.forename: J
authors.initials: J
authors.lastname: Vega-Villar
authors.forename: L
authors.initials: L
authors.lastname: Rodrigo
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications* / Q000178:diet therapy / Q000276:immunology / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D002446:Celiac Disease / Q000150:complications* / Q000178:diet therapy / Q000276:immunology / Q000473:pathology; D055050:Diet, Gluten-Free; D020022:Genetic Predisposition to Disease; D005983:Glutens / Q000276:immunology*; D006801:Humans; D009422:Nervous System Diseases / Q000178:diet therapy / Q000209:etiology* / Q000276:immunology* / Q000473:pathology
chemical_list: D015415:Biomarkers; D005983:Glutens