title: [Metabolism inhibition stimulates, metabolism activation inhibits cancerogenic activity of ortho-aminoazotoluene in mouse liver].
abstract: Pentachlorophenol, an inhibitor of metabolic activation of aminoazo dyes was administered to suckling mice prior to o-aminoazotoluene (OAT). It was followed by formation of numerous preneoplastic nodules and tumors in the lungs and liver. At the same time, 2,3,7,8-tetrachlorodibenzo-p-dioxine treatment decreased their number in the liver while slightly increasing them in the lung. A possible mechanism of aminoazo dye carcinogenicity is suggested.
authors.forename: V I
authors.initials: VI
authors.lastname: Kaledin
authors.forename: S I
authors.initials: SI
authors.lastname: Il'nitskaia
mesh_terms: D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D004396:Coloring Agents / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010416:Pentachlorophenol / Q000494:pharmacology; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology* / Q000633:toxicity; D011230:Precancerous Conditions / Q000139:chemically induced*; D009762:o-Aminoazotoluene / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D004396:Coloring Agents; D000072317:Polychlorinated Dibenzodioxins; D010416:Pentachlorophenol; D009762:o-Aminoazotoluene