title: A general phosphoric acid-catalyzed desymmetrization of meso-aziridines with silylated selenium nucleophiles.
abstract: The first example of meso-aziridine desymmetrization with selenium nucleophiles is reported. The reaction, promoted by VAPOL-hydrogen phosphate using (phenylseleno)trimethylsilane as the nucleophile, proves to be very general and highly enantioselective (84-99% ee).
authors.affiliation: Dipartimento di Chimica e Biologia, Università degli Studi di Salerno, Fisciano (SA), Italy.
authors.forename: Matilde
authors.initials: M
authors.lastname: Senatore
authors.forename: Alessandra
authors.initials: A
authors.lastname: Lattanzi
authors.forename: Stefano
authors.initials: S
authors.lastname: Santoro
authors.forename: Claudio
authors.initials: C
authors.lastname: Santi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Della Sala
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D016566:Organoselenium Compounds / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry*; D013237:Stereoisomerism; D014297:Trimethylsilyl Compounds / Q000737:chemistry
chemical_list: D001388:Aziridines; D016566:Organoselenium Compounds; D010756:Phosphoric Acids; D014297:Trimethylsilyl Compounds; C030242:phosphoric acid