title: Effects of transient receptor potential-like current on the firing pattern of action potentials in the Hodgkin-Huxley neuron during exposure to sinusoidal external voltage.
abstract: Transient receptor potential vanilloid-1 (TRPV1) channels play a role in several inflammatory and nociceptive processes. Previous work showed that magnetic electrical field-induced antinociceptive [corrected] action is mediated by activation of capsaicin-sensitive sensory afferents. In this study, a modified Hodgkin-Huxley model, in which TRP-like current (ITRP) was incorporated, was implemented to predict the firing behavior of action potentials (APs), as the model neuron was exposed to sinusoidal changes in externally-applied voltage. When model neuron is exposed to low-frequency sinusoidal voltage, increased maximal conductance of ITRP can enhance repetitive bursts of APs accompanied by a shortening of inter-spike interval (ISI) in AP firing. The change in ISIs with number of interval is periodic with the phase-locking. In addition, increased maximal conductance of ITRP can abolish chaotic pattern of AP firing in model neuron during exposure to high-frequency voltage. The ISI pattern is converted from irregular to constant, as maximal conductance of ITRP is increased under such high-frequency voltage. Our simulation results suggest that modulation of TRP-like channels functionally expressed in small-diameter peripheral sensory neurons should be an important mechanism through which it can contribute to the firing pattern of APs.
authors.affiliation: Department of Anesthesiology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, China.
authors.forename: Bing-Shuo
authors.initials: BS
authors.lastname: Chen
authors.forename: Yi-Ching
authors.initials: YC
authors.lastname: Lo
authors.forename: Yen-Chin
authors.initials: YC
authors.lastname: Lius
authors.forename: Sheng-Nan
authors.initials: SN
authors.lastname: Wu
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D004558:Electric Stimulation; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D008962:Models, Theoretical; D011984:Sensory Receptor Cells / Q000502:physiology*; D050051:Transient Receptor Potential Channels / Q000502:physiology*
chemical_list: D050051:Transient Receptor Potential Channels