title: Hybrid nanocrystals: achieving concurrent therapeutic and bioimaging functionalities toward solid tumors.
abstract: Bioimaging and therapeutic agents accumulated in ectopic tumors following intravenous administration of hybrid nanocrystals to tumor-bearing mice. Solid, nanosized paclitaxel crystals physically incorporated fluorescent molecules throughout the crystal lattice and retained fluorescent properties in the solid state. Hybrid nanocrystals were significantly localized in solid tumors and remained in the tumor for several days. An anticancer effect is expected of these hybrid nanocrystals.
authors.affiliation: Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, United States.
authors.forename: Rongsheng
authors.initials: R
authors.lastname: Zhao
authors.forename: Christin P
authors.initials: CP
authors.lastname: Hollis
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Lili
authors.initials: L
authors.lastname: Sun
authors.forename: Richard A
authors.initials: RA
authors.lastname: Gemeinhart
authors.forename: Tonglei
authors.initials: T
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D057054:Molecular Imaging; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000648:ultrastructure; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D010316:Particle Size; D011897:Random Allocation; D012995:Solubility; D014018:Tissue Distribution; D047368:Tumor Burden / Q000187:drug effects; D051598:Whole Body Imaging; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005456:Fluorescent Dyes; D017239:Paclitaxel