title: [Rationale for intraoperative intrapelvic chemotherapy in combination with hyperthermia in the treatment of rectal cancer].
abstract: Neoadjuvant treatment should not be given to grave cases of rectal cancer with concomitant perifocal inflammation, anemia and advanced age. To improve results, intraoperative intrapelvic chemotherapy in combination with hyperthermia was carried out at the Center's Clinic. Pre-clinical studies involved working out optimal cryo-temporal regimens to maximize cytotoxic effects of drugs and hyperthermia as well as establishing systemic influence of local hyperthermia and chemotherapy on the intraoperative intrapelvic one. Our optimal cryo-temporal regimens and intraoperative intrapelvic chemotherapy proved highly effective.
authors.forename: M V
authors.initials: MV
authors.lastname: Alekseev
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Shelygin
authors.forename: I A
authors.initials: IA
authors.lastname: Revel'skiĭ
authors.forename: E G
authors.initials: EG
authors.lastname: Rybakov
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery*; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002470:Cell Survival / Q000187:drug effects; D017024:Chemotherapy, Adjuvant; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010388:Pelvis; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D012307:Risk Factors; D013696:Temperature; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin