title: Finite element study of a tissue-engineered cartilage transplant in human tibiofemoral joint.
abstract: Most tissue-engineered cartilage constructs are more compliant than native articular cartilage (AC) and are poorly integrated to the surrounding tissue. To investigate the effect of an implanted tissue-engineered construct (TEC) with these inferior properties on the mechanical environment of both the engineered and adjacent native tissues, a finite element study was conducted. Biphasic swelling was used to model tibial cartilage and an implanted TEC with the material properties of either native tissue or a decreased elastic modulus and fixed charged density. Creep loading was applied with a rigid impermeable indenter that represented the femur. In comparison with an intact joint, compressive strains in the transplant, surface contact stress in the adjacent native AC and load partitioning between different phases of cartilage were affected by inferior properties of TEC. Results of this study may lead to a better understanding of the complex mechanical environment of an implanted TEC.
authors.affiliation: Bioengineering Graduate Program, Aerospace and Mechanical Engineering Department, University of Notre Dame, Notre Dame, IN, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Vahdati
authors.forename: Diane R
authors.initials: DR
authors.lastname: Wagner
mesh_terms: D001696:Biomechanical Phenomena / Q000502:physiology; D002358:Cartilage, Articular / Q000502:physiology; D019245:Compressive Strength / Q000502:physiology; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D020342:Finite Element Analysis; D006801:Humans; D051457:Hyaline Cartilage / Q000637:transplantation*; D007719:Knee Joint / Q000502:physiology / Q000601:surgery*; D008954:Models, Biological; D023822:Tissue Engineering; D016474:Weight-Bearing / Q000502:physiology