title: Comparison of patients of chronic laryngitis with and without troublesome reflux symptoms.
abstract: OBJECTIVE
  Little is known about the difference between patients of chronic laryngitis with and without troublesome reflux symptoms. The aim of this study was to compare the clinical characteristics and response to acid suppression between patients of chronic laryngitis with and without troublesome reflux symptoms.
  
  
  METHODS
  Consecutive patients with chronic laryngitis were enrolled. The frequency and severity of reflux and laryngeal symptoms were scored. All the patients underwent laryngoscopy, esophagogastroduodenoscopy and 24-h multichannel intraluminal impedance and pH monitoring before receiving rabeprazole 10 mg b.i.d. for 3 months. Mild typical reflux symptoms (heartburn or regurgitation) occurring ≥ 2 days/week or moderate/severe symptoms occurring ≥ 1 day/week were defined as troublesome reflux symptoms.
  
  
  RESULTS
  Compared to patients without troublesome reflux symptoms, those with troublesome reflux symptoms were older and had more episodes of acid and liquid gastroesophageal reflux (GER) and acid and weakly acidic laryngopharyngeal reflux (LPR). They also had higher percentages of both bolus exposure time and acid exposure time of GER and LPR. Patients with troublesome reflux symptoms responded to acid suppression more often at 12 weeks (67.3% vs 20.9%, P < 0.001) and more rapidly (40.8% vs 14.0%, 3 weeks after the start of acid suppression; P = 0.004) compared to those without.
  
  
  CONCLUSIONS
  Difference in reflux profile of GER and LPR between patients with and without troublesome reflux symptoms could partly explain the discrepancy of response to acid suppression among patients with chronic laryngitis. Acid suppression therapy may provide limited therapeutic benefits to patients of chronic laryngitis without troublesome reflux symptoms.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: An Jiang
authors.initials: AJ
authors.lastname: Wang
authors.forename: Mao Jin
authors.initials: MJ
authors.lastname: Liang
authors.forename: Ai Yun
authors.initials: AY
authors.lastname: Jiang
authors.forename: Jin Kun
authors.initials: JK
authors.lastname: Lin
authors.forename: Ying Lian
authors.initials: YL
authors.lastname: Xiao
authors.forename: Sui
authors.initials: S
authors.lastname: Peng
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Wei Ping
authors.initials: WP
authors.lastname: Wen
authors.forename: Min Hu
authors.initials: MH
authors.lastname: Chen
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use; D000328:Adult; D000367:Age Factors; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002908:Chronic Disease; D016145:Endoscopy, Digestive System; D050782:Esophageal pH Monitoring; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D006356:Heartburn / Q000209:etiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D007827:Laryngitis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D057045:Laryngopharyngeal Reflux / Q000150:complications / Q000188:drug therapy*; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D064750:Rabeprazole; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D064750:Rabeprazole