title: Selective removal of 17β-estradiol with molecularly imprinted particle-embedded cryogel systems.
abstract: The selective removal of 17β-estradiol (E2) was investigated by using molecularly E2 imprinted (MIP) particle embedded poly(hydroxyethyl methacrylate) (PHEMA) cryogel. PHEMA/MIP composite cryogel was characterized by FTIR, SEM, swelling studies, and surface area measurements. E2 adsorption studies were performed by using aqueous solutions which contain various amounts of E2. The specificity of PHEMA/MIP cryogel to recognition of E2 was performed by using cholesterol and stigmasterol. PHEMA/MIP cryogel exhibited a high binding capacity (5.32 mg/gpolymer) and high selectivity for E2 in the presence of competitive molecules, cholesterol (k(E2/cholesterol) = 7.6) and stigmasterol (k(E2/Stigmasterol) = 85.8). There is no significant decrease in adsorption capacity after several adsorption-desorption cycles.
authors.affiliation: Chemistry Department, Biochemistry Division, Hacettepe University, Ankara, Turkey.
authors.forename: İlker
authors.initials: İ
authors.lastname: Koç
authors.forename: Gözde
authors.initials: G
authors.lastname: Baydemir
authors.forename: Engin
authors.initials: E
authors.lastname: Bayram
authors.forename: Handan
authors.initials: H
authors.lastname: Yavuz
authors.forename: Adil
authors.initials: A
authors.lastname: Denizli
mesh_terms: D000327:Adsorption; D002623:Chemistry Techniques, Analytical; D002784:Cholesterol / Q000737:chemistry; D059985:Cryogels / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D004958:Estradiol / Q000032:analysis*; D006801:Humans; D008855:Microscopy, Electron, Scanning / Q000379:methods; D054802:Molecular Imprinting / Q000379:methods*; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013265:Stigmasterol / Q000737:chemistry; D013499:Surface Properties; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D059985:Cryogels; D004952:Esters; D011108:Polymers; D014874:Water Pollutants, Chemical; D011102:Polyhydroxyethyl Methacrylate; D004958:Estradiol; D002784:Cholesterol; D013265:Stigmasterol