title: Hepcidin: another culprit for complications in patients with chronic kidney disease?
abstract: Hepcidin has been established as a central regulator of iron metabolism. In most patients with chronic kidney disease (CKD), serum hepcidin levels are relatively high, favoring iron sequestration in several cell types and organs and thereby leading to iron-related complications. In the absence of overt inflammation, serum hepcidin has been found to be most closely associated with serum ferritin in healthy subjects and in CKD patients. Intestinal iron absorption is tightly regulated by both iron stores and hepcidin. The expression of the mammalian iron exporter, ferroportin (FPN), limits the growth of intracellular bacteria by depleting cytosolic iron. An upregulation of hepcidin could diminish FPN and favor bacterial growth. Of note, in patients with hyperferritinemia impaired hepcidin expression caused by a mutation in the hemochromatosis gene associates with an attenuation of atherosclerosis. Thus, hepcidin might accelerate atherosclerosis by preventing iron exit from macrophages or other cells in the arterial wall. High hepcidin levels have also been found to be linked to good erythropoiesis-stimulating agents (ESAs) response, in conjunction with the strong hepcidin-ferritin correlation. Finally, hepcidin may also play a significant role by itself in the pathogenesis of CKD complications associated with disturbed iron metabolism, i.e. unrelated to ESA hyporesponsiveness, such as bacterial infections and atherosclerosis.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hasuike
authors.forename: Yoshinaga
authors.initials: Y
authors.lastname: Otaki
authors.forename: Aritoshi
authors.initials: A
authors.lastname: Kida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nonoguchi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kuragano
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D023181:Antimicrobial Cationic Peptides / Q000009:adverse effects*; D064451:Hepcidins; D006801:Humans; D019190:Iron Overload / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000150:complications*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins