title: Chromate toxicity and the role of sulfur.
abstract: The molecular mode(s)-of-action of the toxic metal chromium has yet to be fully resolved. This Mini review focuses on interactions between chromate and sulfur in biological systems. Cr binds sulfur ligands, with cysteine and glutathione having the capacity to aggravate or ameliorate Cr toxicity. Competition between chromate and sulfate for uptake and in metabolism provokes sulfur starvation, which can be growth limiting. Recent data indicate that sulfur deficiency determines protein damage-related Cr toxicity, due to mRNA mistranslation caused by Cr-induced S limitation. Sulfur deprivation could contribute to additional aspects of Cr toxicity, including oxidative DNA damage and Cr related disease.
authors.affiliation: School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
authors.forename: Sara L
authors.initials: SL
authors.lastname: Holland
authors.forename: Simon V
authors.initials: SV
authors.lastname: Avery
mesh_terms: D000818:Animals; D027321:Anion Transport Proteins / Q000235:genetics / Q000378:metabolism; D002840:Chromates / Q000378:metabolism* / Q000633:toxicity*; D003545:Cysteine / Q000378:metabolism; D004249:DNA Damage; D005978:Glutathione / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008024:Ligands; D010084:Oxidation-Reduction; D014176:Protein Biosynthesis / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism; D013455:Sulfur / Q000378:metabolism*
chemical_list: D027321:Anion Transport Proteins; D002840:Chromates; D008024:Ligands; D012333:RNA, Messenger; D013431:Sulfates; D013455:Sulfur; D005978:Glutathione; D003545:Cysteine