title: Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease.
abstract: OBJECTIVE
  The gene for mast cell chymase (CMA1) is an ideal candidate for investigating the genetic predisposition to coronary heart disease (CHD), as activated mast cells have been found to be present in a greater proportion in the shoulder region of atheroma than in normal coronary intimae. Previous studies have indicated that CMA1 promoter polymorphism rs1800875 may be involved in regulating immunoglobulin E (IgE) levels in patients with eczema, and it is associated with the progression of immunoglobulin A nephropathy.
  
  
  METHODS
  The association between single nucleotide polymorphism (SNP) rs1800875, serum chymase, and serum IgE levels was examined in 175 CHD subjects and 95 non-CHD subjects.
  
  
  RESULTS
  Statistical analysis indicated no significant difference in allele frequency between CHD and non-CHD. However, a significant association was found between CMA1 genotypes and total IgE levels in CHD subjects. Meanwhile, crossover analysis revealed that, in GG homozygotes, CHD risk was nearly six times higher in those with IgE (U/ml) level <2.58 (natural logarithm conversion), while no association was found with chymase level.
  
  
  CONCLUSIONS
  Polymorphism rs1800875 of CMA1 may be associated with serum IgE level in CHD subjects, but not with chymase level in both groups. In GG homozygotes, high IgE level is a protective factor against coronary disease.
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Chun-Na
authors.initials: CN
authors.lastname: Jin
authors.forename: Hong
authors.initials: H
authors.lastname: Ma
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Jian-An
authors.initials: JA
authors.lastname: Wang
authors.forename: Mei-Xiang
authors.initials: MX
authors.lastname: Xiang
mesh_terms: D000368:Aged; D053818:Chymases / Q000097:blood* / Q000235:genetics; D003251:Constriction, Pathologic; D003327:Coronary Disease; D004485:Eczema / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000235:genetics; D008297:Male; D008407:Mast Cells / Q000201:enzymology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D007073:Immunoglobulin E; D053818:Chymases