title: Eca20 microsatellite polymorphisms in equine viral arteritis-infected horses from Argentina.
abstract: We investigated the association of equine arteritis virus (EAV) infection and three short tandem repeat (STR) polymorphisms located within or in close proximity to equine lymphocyte antigen (ELA) region. We used a case-control design as a first approach before proceeding to select candidate genes. One hundred and sixty-five Silla Argentino horses were taken in 2002 from positive serological detections of EAV in Argentina, to determine whether STR genotypes were correlated to genetic susceptibility to EVA. Allele frequency distribution did not show significant differences between both groups (P = 0.0781). However, in particular alleles, Fisher exact test and odds ratio calculations showed significant values >1 for TKY08 and LEX52, and <1 for UM011, TKY08, LEX52 and VHL20. Interestingly, TKY08 STR is located in ELA class I region.
authors.affiliation: Instituto de Genética Veterinaria Ing. Fernando N Dulout (IGEVET)-CCT La Plata-CONICET, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina.
authors.forename: P B
authors.initials: PB
authors.lastname: Kalemkerian
authors.forename: G E
authors.initials: GE
authors.lastname: Metz
authors.forename: P
authors.initials: P
authors.lastname: Peral-García
authors.forename: J
authors.initials: J
authors.lastname: Lopez-Gappa
authors.forename: M G
authors.initials: MG
authors.lastname: Echeverría
authors.forename: G
authors.initials: G
authors.lastname: Giovambattista
authors.forename: S
authors.initials: S
authors.lastname: Díaz
mesh_terms: D000483:Alleles; D000818:Animals; D001118:Argentina; D018174:Arterivirus Infections / Q000235:genetics* / Q000276:immunology; D007240:Equartevirus; D005787:Gene Frequency / Q000235:genetics / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006734:Horse Diseases / Q000235:genetics* / Q000276:immunology / Q000821:virology; D006736:Horses; D018895:Microsatellite Repeats / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic
chemical_list: D015395:Histocompatibility Antigens Class I