title: K2CO3-promoted domino reactions: construction of functionalized 2,3-dihydrobenzofurans and clofibrate analogues.
abstract: The K(2)CO(3)-catalyzed domino reactions (Michael alkylation, Mannich alkylation, and aldol alkylation) of salicylic aldehyde derivatives (2-hydroxyaryl-α,β-unsaturated ketones, 2-hydroxyarylnitroalkenes, 2-hydroxyarylimines, and salicylic aldehydes) and 2-halo-1,3-dicarbonyl compounds (diethyl α-bromomalonate, diethyl α-chloromalonate, ethyl 2-chloroacetoacetate, and 3-chloropentane-2,4-dione) were carried out under mild conditions to provide a series of functionalized 2,3-dihydrobenzofurans in moderate to excellent yields. The novel transformations simultaneously gave a series of clofibrate analogues, which possess various substitution patterns.
authors.affiliation: Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry and Life Science, Zhejiang Normal University, 321004 Jinhua, People's Republic of China.
authors.forename: Qu-Bo
authors.initials: QB
authors.lastname: Li
authors.forename: Fei-Ting
authors.initials: FT
authors.lastname: Zhou
authors.forename: Zheng-Geng
authors.initials: ZG
authors.lastname: Liu
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Li
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhu
authors.forename: Jian-Wu
authors.initials: JW
authors.lastname: Xie
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D002994:Clofibrate / Q000737:chemistry*; D015394:Molecular Structure; D011188:Potassium / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D002254:Carbonates; C037593:potassium carbonate; D002994:Clofibrate; D011188:Potassium