title: Selected markers of cardiovascular disease in a population exposed to arsenic from drinking water.
abstract: This study examined prevalence and serum levels of selected markers of cardiovascular disease in 34 subjects from a Croatian rural population exposed to high levels of arsenic (As) from drinking water (611.89±10.06μg/l). The prevalences of overweight and obese subjects in the population were 32% and 35%. Half the subjects had hypertension, 29% had increased fasting serum glucose level and two were diabetic. Median total cholesterol (5.82mmol/l) and triglycerides (2.15mmol/l) were above the desirable margins. The median C-reactive protein level (1.20mg/l) was slightly higher than previously reported for healthy subjects. Serum Hsp70 level was significantly higher in nonsmokers. Total urinary As levels were positively correlated with age-adjusted serum levels of cobalamin. Near significance were also serum total bilirubin, antibodies to Hsp60 and folate. Tentative investigation of risk factors among subjects classified by tumor necrosis factor-α -308G/A and interleukin-6-174G/C gene polymorphisms was also performed. Collectively, the results are in agreement with the hypothesis of As-induced and/or compounded cardiovascular disease.
authors.affiliation: Institute of Public Health for Osijek-Baranya County, Osijek, Croatia.
authors.forename: Zinka
authors.initials: Z
authors.lastname: Bošnjak
authors.forename: Suzana
authors.initials: S
authors.lastname: Cavar
authors.forename: Tomislav
authors.initials: T
authors.lastname: Klapec
authors.forename: Marija
authors.initials: M
authors.lastname: Milić
authors.forename: Mirta
authors.initials: M
authors.lastname: Klapec-Basar
authors.forename: Miroslav
authors.initials: M
authors.lastname: Toman