title: Genome-wide association study of the child behavior checklist dysregulation profile.
abstract: OBJECTIVE
  A potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales (CBCL-DP). The CBCL-DP indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. We have conducted a genome-wide association study of the CBCL-DP in children with attention-deficit/hyperactivity disorder (ADHD).
  
  
  METHODS
  Families were ascertained at Massachusetts General Hospital and University of California, Los Angeles. Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. Genome-wide association analyses were conducted with the MQFAM multivariate extension of PLINK.
  
  
  RESULTS
  CBCL data were available for 341 ADHD offspring from 339 ADHD affected trio families from the UCLA (N = 128) and the MGH (N = 213) sites. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1.
  
  
  CONCLUSIONS
  We found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP.
authors.affiliation: University of Massachusetts Medical School, Worcester, MA 01655, USA. eric.mick@umassmed.edu
authors.forename: Eric
authors.initials: E
authors.lastname: Mick
authors.forename: James
authors.initials: J
authors.lastname: McGough
authors.forename: Sandra
authors.initials: S
authors.lastname: Loo
authors.forename: Alysa E
authors.initials: AE
authors.lastname: Doyle
authors.forename: Janet
authors.initials: J
authors.lastname: Wozniak
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Wilens
authors.forename: Susan
authors.initials: S
authors.lastname: Smalley
authors.forename: James
authors.initials: J
authors.lastname: McCracken
authors.forename: Joseph
authors.initials: J
authors.lastname: Biederman
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
mesh_terms: D000293:Adolescent; D000342:Affective Symptoms / Q000453:epidemiology* / Q000235:genetics*; D000077548:Anaplastic Lymphoma Kinase; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology* / Q000235:genetics*; D002140:California / Q000453:epidemiology; D002648:Child; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D006360:Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D008404:Massachusetts / Q000453:epidemiology; D008565:Membrane Proteins / Q000235:genetics; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D011581:Psychological Tests; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D040121:Semaphorin-3A / Q000235:genetics; D012795:Sialoglycoproteins / Q000235:genetics; D035781:Siblings / Q000523:psychology
chemical_list: D006360:Heat-Shock Proteins; C504461:LRRC7 protein, human; D008565:Membrane Proteins; C108639:SEMA3A protein, human; C079373:STIP1 protein, human; D040121:Semaphorin-3A; D012795:Sialoglycoproteins; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases