title: Role of serum interleukin-6 in comparing surgical stress after laparoscopic-assisted vaginal hysterectomy and non-descent vaginal hysterectomy for large uteri.
abstract: OBJECTIVE
  To compare the perioperative inflammatory response using interleukin-6 (IL-6) in patients of laparoscopic-assisted vaginal hysterectomy (LAVH) and non-descent vaginal hysterectomy (NDVH) for large uteri with benign disease.
  
  
  METHODS
  Twenty women with benign uterine disease and failed medical management with size of uterus ranging from 300 to 1,500 g (12-24 weeks) were randomized into two equal groups for either technique of hysterectomy, LAVH and NDVH. Venous blood levels of IL-6 were measured preoperatively and 3, 24 and 72 h after beginning of surgery. Statistical analysis was done using SPSS15 software.
  
  
  RESULTS
  No statistically significant difference was present in demographic characteristics, operating time, and uterine weight between the two groups. No major complications were encountered. The increase in serum interleukin 6 levels from preoperative value to the value at 3 h postoperatively was found to be significantly higher in LAVH group when compared with NDVH group indicating greater tissue handling and trauma in LAVH group.
  
  
  CONCLUSIONS
  Non-descent vaginal hysterectomy appears to be better than laparoscopic-assisted vaginal hysterectomy for large uteri in terms of inflammatory response.
authors.affiliation: Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India. drkkroy2003@gmail.com
authors.forename: Kallol Kumar
authors.initials: KK
authors.lastname: Roy
authors.forename: Murali
authors.initials: M
authors.lastname: Subbaiah
authors.forename: Shilpa
authors.initials: S
authors.lastname: Singla
authors.forename: Sunesh
authors.initials: S
authors.lastname: Kumar
authors.forename: Jai Bhagwan
authors.initials: JB
authors.lastname: Sharma
authors.forename: Dipender Kumar
authors.initials: DK
authors.lastname: Mitra
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical; D005260:Female; D006801:Humans; D007045:Hysterectomy, Vaginal / Q000379:methods*; D015850:Interleukin-6 / Q000097:blood*; D010535:Laparoscopy / Q000379:methods*; D008875:Middle Aged; D013312:Stress, Physiological; D016896:Treatment Outcome; D014591:Uterine Diseases / Q000601:surgery
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6