title: [Serum level of sL-selectin and leukocyte surface expression of L-selectin in patients with type 2 diabetes].
abstract: The aims of the study were assessment of serum level of sL-selectin and leukocyte (neutrophil and monocyte) surface expression of L-selectin in peripheral blood. Subjects and methods. Eighty patients with type 2 diabetes were enrolled in the study. The diabetic patients were divided into three groups: group A--diabetic micro-angiopathy, group B--diabetic macroangiopathy and group C--patients without vascular complications. The control group included 20 healthy volunteers. Serum level of sL-selectin was determined by immunoenzymatic assay. Flow cytometry was used to analyse surface expresion of L-selectin. Results. In patients with type 2 diabetes sL-selectin level was significantly decreased in comparison with control group. Serum level of sL-selectin did not significantly vary between diabetic groups. In patients with diabetic microangiopathy and macroangiopathy leukocyte expression of L-selectin was significantly lower in comparison with the healthy control and patients without vascular complications.
  
  
  CONCLUSIONS
  Serum level of sL-selectin is decreased in patients with type 2 diabetes. The development of chronic vascular complications, diabetic micro- and macroangiopathy, is accompanied by decrease of leukocyte surface expression of L-selectin.
authors.affiliation: Katedra i Klinika Angiologii, Nadciśnienia Tetniczego i Diabetologii Akademii Medycznej we Wrocławiu. kmastej@interia.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Mastej
authors.forename: Rajmund
authors.initials: R
authors.lastname: Adamiec
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood / Q000175:diagnosis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D019041:L-Selectin / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D019041:L-Selectin