title: [Testosterone and bone: indications and limitations].
abstract: Osteoporosis incidence increases exponentially with age in men and hypogonadism represents a risk factor. Sex steroids levels are correlated to bone mineral density and to fracture prevalence. Most studies demonstrate an improvement in bone mineral density in men with hypogonadism as a result of testosterone therapy. Nevertheless there are no data evaluating the effect of testosterone therapy on fractures in men. Approximately 20% of men older than 60 have a total testosterone level lower than the lower limit of the reference range but there is no true consensus on the definition of hypogonadism in older men. In older men we recommend to treat only if total morning testosterone levels are < 8 nmol/l or even < 6,9 nmol/l on several occasions in the absence of any reversible illness and if there is no contraindication for treatment.
authors.affiliation: Centre des maladies osseuses, CHUV, Lausanne. Delphine.Stoll@chuv.ch
authors.forename: Delphine
authors.initials: D
authors.lastname: Stoll
authors.forename: Jardena J
authors.initials: JJ
authors.lastname: Puder
authors.forename: Olivier
authors.initials: O
authors.lastname: Lamy
mesh_terms: D000728:Androgens / Q000494:pharmacology / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects*; D006801:Humans; D007006:Hypogonadism / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010024:Osteoporosis / Q000150:complications / Q000209:etiology* / Q000517:prevention & control; D058866:Osteoporotic Fractures / Q000209:etiology / Q000517:prevention & control; D012307:Risk Factors; D013739:Testosterone / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000728:Androgens; D013739:Testosterone