title: Vitamin D status in patients with Behcet's Disease.
abstract: OBJECTIVE
  This study investigated the serum 25-hydroxyvitamin D levels of patients with Behcet's Disease.
  
  
  METHODS
  Thirty-two patients with Behcet's Disease and 31 matched healthy controls were enrolled in this study. The erythrocyte sedimentation rate (ESR) and the levels of C-reactive protein (CRP), serum 25-hydroxyvitamin D, calcium (Ca), phosphate (P), and total alkaline phosphatase (ALP) were measured in both groups.
  
  
  RESULTS
  There were no significant differences between the two groups regarding demographic data. The serum 25-hydroxyvitamin D levels of patients and controls were 13.76 (range: 4.00-35.79) and 18.97 (range: 12.05-36.94) ng/ml, respectively. In patients with Behcet's Disease, 25-hydroxyvitamin D values were significantly lower than those of the healthy controls (p<0.001). Serum Ca, P, and ALP levels were similar in both groups. Serum ESR and CRP levels were significantly higher in patients than controls (p<0.05). There was no correlation between 25-hydroxyvitamin D levels and age, body mass index (BMI), disease duration, ESR, or CRP levels. Multivariate regression analysis parameters showed that smoking, alcohol intake, and use of colchicine were the main predictors of 25-hydroxyvitamin D levels. Of the parameters studied, the largest impact was due to colchicine therapy (p<0.001). We did not find a significant relationship between the use of corticosteroids and 25-hydroxyvitamin D levels.
  
  
  CONCLUSIONS
  Our results suggest that serum 25-hydroxyvitamin D levels are decreased in patients with Behcet's Disease. Smoking, alcohol intake, and use of colchicine appear to affect vitamin D levels.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ataturk University, Medical Faculty, Erzurum-Turkey. skaratay73@hotmail.com
authors.forename: Saliha
authors.initials: S
authors.lastname: Karatay
authors.forename: Kadir
authors.initials: K
authors.lastname: Yildirim
authors.forename: Ali
authors.initials: A
authors.lastname: Karakuzu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kiziltunc
authors.forename: Ragip Ismail
authors.initials: RI
authors.lastname: Engin
authors.forename: Yonca Bavli
authors.initials: YB
authors.lastname: Eren
authors.forename: Akin
authors.initials: A
authors.lastname: Aktas
mesh_terms: D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001528:Behcet Syndrome / Q000097:blood* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D002118:Calcium / Q000097:blood; D016022:Case-Control Studies; D003078:Colchicine / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010710:Phosphates; D014807:Vitamin D; D002097:C-Reactive Protein; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D003078:Colchicine; D002118:Calcium