title: [Processes of free radical lipid peroxidation with a particular regard to the role of paraoxonase-1 in the pathogenesis of multiple sclerosis].
abstract: Oxidative stress is an imbalance between free radicals production and antioxidant defences. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) can attact and demage a variety of critical biological molecules, including lipids, essential cellular proteins and DNA and may be exert in pathogenesis of many disorders. Products of lipid peroxidation can be easily reliably detected in biological fluids and tissues, yielding sensitive and specific signals of lipid peroxidation occurred in vivo. Those products are: isoprostanes (isoP) dimalonealdehyde (MDA), 4-hydroxynonenal (4-HNE). Paraoxonase-1 (PON-1) play a key role in defence of lipid peroxidation. PON-1 is an serum enzyme bound up with high density lipoproteins (HDL). The aim of this work is to discuss the role of oxidative stress in the pathogenesis of multiple sclerosis.
authors.affiliation: Klinika Neurologii z Pododdziałem Udarowym oraz Wczesnej Rehabilitacji Poudarowej, Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie. jerzymed@wp.pl
authors.forename: Jerzy
authors.initials: J
authors.lastname: Berbecki
authors.forename: Krystyna
authors.initials: K
authors.lastname: Mitosek-Szewczyk
authors.forename: Jacek
authors.initials: J
authors.lastname: Kurzepa
authors.forename: Marcin
authors.initials: M
authors.lastname: Nastaj
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Łobejko
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Stelmasiak
mesh_terms: D043303:Aryldialkylphosphatase / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D009103:Multiple Sclerosis / Q000209:etiology / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D005609:Free Radicals; D017382:Reactive Oxygen Species; D043303:Aryldialkylphosphatase