title: Prostate cancer detection by prebiopsy 3.0-Tesla magnetic resonance imaging.
abstract: OBJECTIVE
  The diagnostic value of 3.0-Tesla magnetic resonance imaging (MRI) for prostate cancer remains to be determined. The aim of the present study was to assess the features of prostate cancer detectable by prebiopsy 3.0-Tesla MRI.
  
  
  METHODS
  From January 2007 through to December 2008, 116 patients who were examined by prebiopsy 3.0-Tesla MRI underwent radical prostatectomy for localized prostate cancer. Prostate specimens were examined to see whether the largest cancer area was the same as the area indicated on the MRI. Univariate and multivariate logistic regression analyses were conducted to identify variables predictive of agreement between MRI and histopathological findings.
  
  
  RESULTS
  Sixty-six (56.9%) patients were suspected of having prostate cancer on the basis of MRI findings. In 49 of these patients (74.2%), it was considered that there was agreement between the abnormal area on the MRI and the index tumor. Univariate analysis revealed that there were significant differences in abnormal digital rectal examination, capsular penetration, the diameter of the index tumor of the radical prostatectomy specimen, and the Gleason scores of the biopsy and radical prostatectomy specimens. Multivariate analysis revealed that the Gleason score of the radical prostatectomy specimen was associated with the accurate detection of the prostate cancer by MRI (P = 0.0177).
  
  
  CONCLUSIONS
  In conclusion, 3.0-Tesla MRI tends to accurately diagnose prostate cancer with high tumor burden and aggressiveness. Multimodal examination (T2-weighted imaging, dynamic contrast-enhanced imaging, and diffusion-weighted imaging) is recommended for the diagnosis of prostate cancer using 3.0-Tesla MRI.
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Osaka, Japan. sachi@sapmed.ac.jp
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Nishida
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Takao
authors.initials: T
authors.lastname: Mishima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kurokawa
authors.forename: Noriko
authors.initials: N
authors.lastname: Sakaida
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000368:Aged; D001706:Biopsy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading / Q000379:methods* / Q000592:standards; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods* / Q000592:standards; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D015203:Reproducibility of Results; D012189:Retrospective Studies