title: Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential.
abstract: The RGS1 gene is associated with celiac disease, multiple sclerosis, and type I diabetes, which are all T cell-mediated pathologies, yet there is no reported analysis of regulator of G protein signaling (RGS)1 biology in human T cells. This study shows that RGS1 expression is substantially higher in T cells from human gut versus peripheral blood and that this can be exaggerated in intestinal inflammation. Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines, whereas RGS1 depletion selectively enhances such chemotaxis in gut T cells and impairs their colitogenic potential. These findings provide a revised framework in which to view the linkage of RGS1 to inflammatory disease.
authors.affiliation: Peter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
authors.forename: Deena L
authors.initials: DL
authors.lastname: Gibbons
authors.forename: Lucie
authors.initials: L
authors.lastname: Abeler-Dörner
authors.forename: Tim
authors.initials: T
authors.lastname: Raine
authors.forename: Il-Young
authors.initials: IY
authors.lastname: Hwang
authors.forename: Anett
authors.initials: A
authors.lastname: Jandke
authors.forename: Melanie
authors.initials: M
authors.lastname: Wencker
authors.forename: Livija
authors.initials: L
authors.lastname: Deban
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Rudd
authors.forename: Peter M
authors.initials: PM
authors.lastname: Irving
authors.forename: John H
authors.initials: JH
authors.lastname: Kehrl
authors.forename: Adrian C
authors.initials: AC
authors.lastname: Hayday
mesh_terms: D000818:Animals; D002465:Cell Movement; D002469:Cell Separation; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D003092:Colitis / Q000276:immunology* / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018613:Microscopy, Confocal; D020710:RGS Proteins / Q000276:immunology* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D014162:Transfection
chemical_list: D020710:RGS Proteins; C080831:RGS1 protein, human