title: Perinatal risk indicators for long-term neurological morbidity among preterm neonates.
abstract: OBJECTIVE
  Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2 and 5 years of age.
  
  
  METHODS
  Data from a Dutch cohort study of preterm and small-for-gestational-age infants was used. Neonates who were born in The Netherlands in 1983 with a gestational age of <34 weeks and without congenital abnormalities were included (n = 753). Infants were divided in 3 groups: no handicap, minor handicap, and major handicap.
  
  
  RESULTS
  Common risk indicators for major handicaps at 2 and 5 years of age were male sex (odds ratio, 2.7 and 3.0, respectively), seizures after ≥2 days of life (odds ratio, 5.8 and 5.8, respectively), and intracranial hemorrhage (odds ratio, 3.8 and 2.6, respectively).
  
  
  CONCLUSIONS
  In this cohort, male sex, intracranial hemorrhage, and seizures seem to be important risk indicators for long-term neurologic morbidity.
authors.affiliation: Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam, The Netherlands. m.j.teune@amc.uva.nl.
authors.forename: Margreet J
authors.initials: MJ
authors.lastname: Teune
authors.forename: Aleid G
authors.initials: AG
authors.lastname: van Wassenaer
authors.forename: Paula
authors.initials: P
authors.lastname: van Dommelen
authors.forename: Ben Willem J
authors.initials: BW
authors.lastname: Mol
authors.forename: Brent C
authors.initials: BC
authors.lastname: Opmeer
mesh_terms: D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D008297:Male; D009422:Nervous System Diseases / Q000175:diagnosis*; D012307:Risk Factors