title: Seroprevalence of trichodysplasia spinulosa-associated polyomavirus.
abstract: We identified a new polyomavirus in skin lesions from a patient with trichodysplasia spinulosa (TS). Apart from TS being an extremely rare disease, little is known of its epidemiology. On the basis of knowledge regarding other polyomaviruses, we anticipated that infections with trichodysplasia spinulosa-associated polyomavirus (TSV) occur frequently and become symptomatic only in immunocompromised patients. To investigate this hypothesis, we developed and used a Luminex-based TSV viral protein 1 immunoassay, excluded cross-reactivity with phylogenetically related Merkel cell polyomavirus, and measured TSV seroreactivity. Highest reactivity was found in a TS patient. In 528 healthy persons in the Netherlands, a wide range of seroreactivities was measured and resulted in an overall TSV seroprevalence of 70% (range 10% in small children to 80% in adults). In 80 renal transplant patients, seroprevalence was 89%. Infection with the new TSV polyomavirus is common and occurs primarily at a young age.
authors.affiliation: Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. p.z.van_der_meijden@lumc.nl
authors.forename: Els
authors.initials: E
authors.lastname: van der Meijden
authors.forename: Siamaque
authors.initials: S
authors.lastname: Kazem
authors.forename: Manda M
authors.initials: MM
authors.lastname: Burgers
authors.forename: Rene
authors.initials: R
authors.lastname: Janssens
authors.forename: Jan Nico
authors.initials: JN
authors.lastname: Bouwes Bavinck
authors.forename: Hester
authors.initials: H
authors.lastname: de Melker
authors.forename: Mariet C W
authors.initials: MC
authors.lastname: Feltkamp
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D036022:Capsid Proteins / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007118:Immunoassay / Q000379:methods; D016867:Immunocompromised Host; D007223:Infant; D016030:Kidney Transplantation / Q000009:adverse effects; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011120:Polyomavirus / Q000276:immunology*; D027601:Polyomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016036:Seroepidemiologic Studies; D012871:Skin Diseases / Q000453:epidemiology* / Q000821:virology; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000821:virology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D036022:Capsid Proteins; C062481:VP1 protein, polyomavirus