title: An unusual case of signet ring cell adenocarcinoma of the prostate.
abstract: We report the case of a 70-year-old man with symptoms of urinary obstruction and haematuria, with histological diagnosis of primary signet-ring cell carcinoma of the prostate. Almost 90% of the tumour cells contained characteristic intracytoplasmic vacuoles that positively stained with diastase-digested PAS, Alcian blue and mucicarmine. The positive immunostaining for PSA and PSAP confirmed the prostatic origin of the tumour. Although the patient received hormonal therapy, the disease progressed and the patient died 11 months after surgery.
authors.affiliation: Dipartimento Integrato Servizi Diagnostici e di Laboratorio e di Medicina Legale, Sezione di Anatomia Patologica. Universitá di Modena e Reggio Emilia, Italy. reggiani.luca@policlinico.mo.it
authors.forename: L Reggiani
authors.initials: LR
authors.lastname: Bonetti
authors.forename: M
authors.initials: M
authors.lastname: Lupi
authors.forename: E
authors.initials: E
authors.lastname: Stauder
authors.forename: S
authors.initials: S
authors.lastname: Bergamini
authors.forename: M
authors.initials: M
authors.lastname: Scuri
authors.forename: A
authors.initials: A
authors.lastname: Maiorana
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D049231:Saposins / Q000378:metabolism
chemical_list: C483345:PSAP protein, human; D049231:Saposins; D017430:Prostate-Specific Antigen