title: Palladium-catalyzed direct ethynylation of C(sp3)-H bonds in aliphatic carboxylic acid derivatives.
abstract: The first catalytic alkynylation of unactivated C(sp(3))-H bonds has been accomplished. The method allows for the straightforward introduction of an ethynyl group into aliphatic acid derivatives under palladium catalysis. This new reaction can be applied to the rapid elaboration of complex aliphatic acids, for example, via azide/alkyne cycloaddition.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ano
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tobisu
authors.forename: Naoto
authors.initials: N
authors.lastname: Chatani
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry
chemical_list: D000480:Alkynes; D002264:Carboxylic Acids; D010165:Palladium