title: Cytotoxic effects of permethrin on mouse liver and spleen cells.
abstract: This study analyzed the histopathological and histochemical effects of different dosages of permethrin on liver and spleen cells of mice, in order to evaluate the toxic potential of this substance and the possible impairments that this chemical causes in different tissues of nontarget organisms (laboratorial conditions). The results showed that permethrin caused severe alterations in the liver cells, reducing the size of the nuclei and causing hydropic degeneration of the hepatocytes, in addition to stimulating the proliferation of Kupffer cells, altered the amount of proteins, polysaccharides, lipids, and vacuoles in the cytoplasm of the hepatocytes and congested the hepatic capillaries. As for the spleen of the treated mice, no alterations were observed in the morphology in relation to the control group, what would suggest that the spleen would continue performing its functions, without suffering morphological alterations even in the presence of the toxic agent.
authors.affiliation: Departamento de Biologia, Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Avenida 24 A, 1515, 13506-900-Rio Claro, SP, Brazil, CP 199.
authors.forename: Gislaine Cristina
authors.initials: GC
authors.lastname: Roma
authors.forename: Patrícia Rosa
authors.initials: PR
authors.lastname: De Oliveira
authors.forename: Gervásio Henrique
authors.initials: GH
authors.lastname: Bechara
authors.forename: Maria Izabel
authors.initials: MI
authors.lastname: Camargo Mathias
mesh_terms: D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000473:pathology; D002467:Cell Nucleus / Q000187:drug effects; D049109:Cell Proliferation; D003593:Cytoplasm / Q000737:chemistry / Q000187:drug effects; D005260:Female; D022781:Hepatocytes / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity; D007728:Kupffer Cells / Q000187:drug effects; D008055:Lipids / Q000737:chemistry; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D026023:Permethrin / Q000008:administration & dosage / Q000633:toxicity*; D011134:Polysaccharides / Q000737:chemistry; D013154:Spleen / Q000187:drug effects*; D018675:Toxicity Tests
chemical_list: D007306:Insecticides; D008055:Lipids; D011134:Polysaccharides; D026023:Permethrin