title: Coexistence of primary aldosteronism and Hashimoto's thyroiditis.
abstract: In light of research carried out in recent years, it seems that aldosterone may produce a complex proinflammatory effect. Theoretically, excessive aldosterone release may stimulate the development and/or progression of autoimmune disorders. In this article, we report a case of a female in whom primary aldosteronism coexisted with Hashimoto's thyroiditis. Surgical removal of an aldosterone-producing tumor improved thyroid function and decreased thyroid autoimmunity. We describe in details diagnostic and treatment strategies applied in our patient and their impact on the course and outcome of thyroiditis. We also present monocyte and lymphocyte cytokine release in the index subjects before and after surgical treatment. We conclude that primary aldosteronism may exacerbate the clinical course of autoimmune thyroiditis and probably also of other autoimmune disorders.
authors.affiliation: Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland. r.krysiak@interia.pl
authors.forename: Robert
authors.initials: R
authors.lastname: Krysiak
authors.forename: Bogusław
authors.initials: B
authors.lastname: Okopien
mesh_terms: D000304:Adrenal Cortex Function Tests; D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D000450:Aldosterone / Q000097:blood; D015551:Autoimmunity; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D050031:Hashimoto Disease / Q000097:blood / Q000150:complications* / Q000276:immunology; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications* / Q000276:immunology; D018836:Inflammation Mediators / Q000097:blood; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; D000451:Mineralocorticoid Receptor Antagonists; D013963:Thyroid Hormones; D000450:Aldosterone; D013974:Thyroxine