title: Long-term survival of a child with refractory anaplastic large cell lymphoma following therapy with an antisense oligonucleotide, topotecan, and vinblastine.
abstract: Anaplastic large cell lymphoma includes a subset of highly aggressive tumours and has a relapse rate of 30% at 2 years. Relapsed patients often have poor clinical outcome. The use of antisense oligonucleotides to down-regulate Bcl-2 protein can reverse chemotherapy resistance. The authors describe an 11-year-old boy with recurrent anaplastic large cell lymphoma who had received double high-dose chemotherapy followed by autologous haematopoietic stem-cell transplantation, had refractory disease and then had achieved long-term remission with the use of an antisense oligonucleotides in combination with vinblastine and topotecan.
authors.affiliation: Department of Bone Marrow Transplantation, Children Oncology and Haematology, Medical University of Wroclaw, Wroclaw, Poland.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Wrobel
authors.forename: Radosław
authors.initials: R
authors.lastname: Chaber
authors.forename: Jolanta
authors.initials: J
authors.lastname: Rygier
authors.forename: Jolanta
authors.initials: J
authors.lastname: Bonar
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Muszynska-Roslan
authors.forename: Alicja
authors.initials: A
authors.lastname: Chybicka
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D015536:Down-Regulation / Q000187:drug effects / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D012074:Remission Induction; D017741:Survivors; D019772:Topotecan / Q000008:administration & dosage; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D016376:Oligonucleotides, Antisense; D019253:Proto-Oncogene Proteins c-bcl-2; D014747:Vinblastine; D019772:Topotecan