title: Encoded dendrimers with defined chiral composition via'click' reaction of enantiopure building blocks.
abstract: Dendrimers with end-groups of defined chiral composition have been prepared from alkyne functional enantio-pure building blocks obtained by selective enzymatic (ADH) ketone reductions using click chemistry. Optical rotation and enantioselective enzymatic modification is in agreement with the chiral composition of the dendrimers and permits unique molecular-level encoding of stereoisomeric dendritic libraries.
authors.affiliation: Technische Universiteit Eindhoven, Laboratory of Polymer Chemistry, Eindhoven, The Netherlands.
authors.forename: Bahar
authors.initials: B
authors.lastname: Yeniad
authors.forename: Hemantkumar
authors.initials: H
authors.lastname: Naik
authors.forename: Roey J
authors.initials: RJ
authors.lastname: Amir
authors.forename: Cor E
authors.initials: CE
authors.lastname: Koning
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Hawker
authors.forename: Andreas
authors.initials: A
authors.lastname: Heise
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism; D057930:Click Chemistry; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D007778:Lactobacillus / Q000201:enzymology; D013237:Stereoisomerism; D046968:Thermoanaerobacter / Q000201:enzymology
chemical_list: D050091:Dendrimers; D007659:Ketones; D000426:Alcohol Dehydrogenase