title: De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly.
abstract: Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PAs into spherical 50 nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.
authors.affiliation: Department of Chemistry and Biochemistry, Materials Research Laboratory, University of California, Santa Barbara, California 93106, United States.
authors.forename: Brian F
authors.initials: BF
authors.lastname: Lin
authors.forename: Rachel S
authors.initials: RS
authors.lastname: Marullo
authors.forename: Maxwell J
authors.initials: MJ
authors.lastname: Robb
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Krogstad
authors.forename: Per
authors.initials: P
authors.lastname: Antoni
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Hawker
authors.forename: Luis M
authors.initials: LM
authors.lastname: Campos
authors.forename: Matthew V
authors.initials: MV
authors.lastname: Tirrell
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D032701:Biomimetics; D050091:Dendrimers / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008823:Micelles; D054118:Nanospheres / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D050091:Dendrimers; D008823:Micelles; D010455:Peptides; D011506:Proteins