title: The logic linking protein acetylation and metabolism.
abstract: Protein acetylation now rivals phosphorylation in frequency of occurrence but is incompletely understood. A picture is presented in which protein acetylation is linked to available energy via the NAD-dependent deacetylases. This model suggests that protein acetylation regulates metabolic strategy and also helps store energy in cells.
authors.affiliation: Paul F. Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. leng@mit.edu
authors.forename: Leonard
authors.initials: L
authors.lastname: Guarente
mesh_terms: D000107:Acetylation; D000818:Animals; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D011506:Proteins; D051548:Histone Acetyltransferases; D037761:Sirtuins; D006655:Histone Deacetylases