title: Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area.
abstract: Visceral fat accumulation has an important role in increasing morbidity and mortality rate by increasing the risk of developing several metabolic disorders, such as type 2 diabetes, dyslipidemia and hypertension. New genetic loci that contribute to the development of obesity have been identified by genome-wide association studies in Caucasian populations. We genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography (CT) for measuring visceral fat area (VFA) and subcutaneous fat area (SFA), for the following single-nucleotide polymorphisms (SNPs): NEGR1 rs2815752, SEC16B rs10913469, TMEM18 rs6548238, ETV5 rs7647305, GNPDA2 rs10938397, BDNF rs6265 and rs925946, MTCH2 rs10838738, SH2B1 rs7498665, MAF rs1424233, and KCTD15 rs29941 and rs11084753. In the additive model, none of the SNPs were significantly associated with body mass index (BMI). The SH2B1 rs7498665 risk allele was found to be significantly associated with VFA (P=0.00047) but not with BMI or SFA. When the analysis was performed in men and women separately, no significant associations with VFA were observed (P=0.0099 in men and P=0.022 in women). None of the other SNPs were significantly associated with SFA. Our results suggest that there is a VFA-specific genetic factor and that a polymorphism in the SH2B1 gene influences the risk of visceral fat accumulation.
authors.affiliation: EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan. kikukoh@kuhp.kyoto-u.ac.jp
authors.forename: Kikuko
authors.initials: K
authors.lastname: Hotta
authors.forename: Takuya
authors.initials: T
authors.lastname: Kitamoto
authors.forename: Aya
authors.initials: A
authors.lastname: Kitamoto
authors.forename: Seiho
authors.initials: S
authors.lastname: Mizusawa
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Matsuo
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Nakata
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hyogo
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ochi
authors.forename: Seika
authors.initials: S
authors.lastname: Kamohara
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyatake
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kotani
authors.forename: Ryoya
authors.initials: R
authors.lastname: Komatsu
authors.forename: Naoto
authors.initials: N
authors.lastname: Itoh
authors.forename: Ikuo
authors.initials: I
authors.lastname: Mineo
authors.forename: Jun
authors.initials: J
authors.lastname: Wada
authors.forename: Masato
authors.initials: M
authors.lastname: Yoneda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Katsuto
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Masuzaki
authors.forename: Takato
authors.initials: T
authors.lastname: Ueno
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Chayama
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hamaguchi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamada
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hanafusa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oikawa
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yoshimatsu
authors.forename: Toshiie
authors.initials: T
authors.lastname: Sakata
authors.forename: Kiyoji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuzawa
authors.forename: Kazuwa
authors.initials: K
authors.lastname: Nakao
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sekine
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics*; D050218:Body Fat Distribution; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D007564:Japan; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C518910:SH2B1 protein, human