title: Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats.
abstract: The toxicokinetic characteristics of naringin were investigated in rats that had been orally administered naringin extract, a candidate for oral treatment of cough, prepared from Citrus grandis "Tomentosa", at 50, 250, or 1250 mg/kg/day in a repeated-dose study for 1, 32, 93, or 184 days. Increased values of the mean systemic exposure were approximately proportional to increases in dose levels during all collection intervals; no saturation was observed. No significant differences in mean systemic exposure were observed between male and female rats. Results provide a reference for interpretation of toxicology findings and relevance to clinical safety issues.
authors.affiliation: Guangzhou Quality R&D Center of Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Menghua
authors.initials: M
authors.lastname: Liu
authors.forename: Cuiping
authors.initials: C
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Zou
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Guan
authors.forename: Wenyan
authors.initials: W
authors.lastname: Zheng
authors.forename: Li
authors.initials: L
authors.lastname: Lai
authors.forename: Siqi
authors.initials: S
authors.lastname: Fang
authors.forename: Shuxing
authors.initials: S
authors.lastname: Cai
authors.forename: Weiwei
authors.initials: W
authors.lastname: Su
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000996:Antitussive Agents / Q000493:pharmacokinetics* / Q000633:toxicity*; D019540:Area Under Curve; D001522:Behavior, Animal / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004435:Eating / Q000187:drug effects; D005260:Female; D044950:Flavanones / Q000493:pharmacokinetics* / Q000633:toxicity*; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000996:Antitussive Agents; D044950:Flavanones; C005274:naringin