title: Coenzyme Q10 and its relation with oxidant and antioxidant system markers in patients with end-stage renal disease.
abstract: OBJECTIVE
  Oxidative stress is increased in chronic kidney disease (CKD) patients and end-stage renal disease (ESRD) patients undergoing dialysis treatment. Coenzyme Q(10) (CoQ(10)) is a ubiquitous and strong antioxidant. Role of CoQ(10) is not fully evaluated in renal patients. We aimed to investigate the relationship of CoQ(10) with oxidant and antioxidant system markers in patients with renal disease.
  
  
  METHODS
  Forty patients with CKD (stages 3-5) who were managed conservatively without dialysis treatment, 40 hemodialysis, and 60 chronic ambulatory peritoneal dialysis (CAPD) patients were included in the study. Biochemical and whole blood analyses were done using hospital auto-analyzers from stored samples. Serum CoQ(10), malondialdehyde (MDA), superoxide dismutase (SOD), and antioxidant activity (AOA) levels were determined.
  
  
  RESULTS
  There was no difference among the groups in terms of serum CoQ(10) levels. However, other components of antioxidant system, namely, SOD and AOA were significantly higher in CAPD patients when compared to CKD patients. MDA levels were not significantly different among the groups. PRINCIPAL CONCLUSION(S): The results of this study showed no difference among CKD, CAPD, and hemodialysis patients in terms of serum CoQ(10) levels.
authors.affiliation: Department of Physiology, Meram School of Medicine, Selcuk University, Meram, Konya, Turkey.
authors.forename: Hakki
authors.initials: H
authors.lastname: Gokbel
authors.forename: Huseyin
authors.initials: H
authors.lastname: Atalay
authors.forename: Nilsel
authors.initials: N
authors.lastname: Okudan
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Solak
authors.forename: Muaz
authors.initials: M
authors.lastname: Belviranli
authors.forename: Suleyman
authors.initials: S
authors.lastname: Turk
mesh_terms: D000975:Antioxidants / Q000502:physiology*; D015415:Biomarkers / Q000378:metabolism; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology / Q000378:metabolism* / Q000628:therapy; D008875:Middle Aged; D018384:Oxidative Stress; D010530:Peritoneal Dialysis; D006435:Renal Dialysis; D013482:Superoxide Dismutase / Q000378:metabolism*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014451:Ubiquinone; D013482:Superoxide Dismutase; C024989:coenzyme Q10