title: New 3',8''-linked biflavonoids from Selaginella uncinata displaying protective effect against anoxia.
abstract: Seven 3',8''-linked bioflavonoids, including one new compound, (2''S)-2'', 3''-dihydroamentoflavone-4'-methyl ether and six known compounds: (2S)-2,3- dihydroamentoflavone-4'-methyl ether, (2S,2''S)-2,3,2'',3''-tetrahydroamento- flavone-4'-methyl ether, (2S,2''S)-tetrahydroamentoflavone, (2S)-2,3-dihydro- amentoflavone and (2''S)-2'',3''-dihydroamentoflavone (6) and amentoflavone, were isolated from the 60% ethanolic extract of Selaginella uncinata (Desv.) Spring. The structures of these compounds were elucidated mainly by analysis of their 1D and 2D NMR spectroscopic data, and their absolute configurations were determined by circular-dichroism (CD) spectroscopy. All the seven compounds showed protective effect against anoxia in the anoxic PC12 cells assay, in which compound 6 displayed particularly potent activity.
authors.affiliation: Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China. junxiazheng@163.com
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Zheng
authors.forename: Yang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Hui
authors.initials: H
authors.lastname: Zhi
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.forename: Nai-Li
authors.initials: NL
authors.lastname: Wang
authors.forename: Yan-Xiong
authors.initials: YX
authors.lastname: Fang
authors.forename: Zhi-Yun
authors.initials: ZY
authors.lastname: Du
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Li
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
mesh_terms: D000532:Altitude Sickness / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D044946:Biflavonoids / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D002236:Carbohydrate Conformation; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D000431:Ethanol / Q000737:chemistry; D005419:Flavonoids / Q000494:pharmacology; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D009682:Magnetic Resonance Spectroscopy; D016716:PC12 Cells; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D032503:Selaginellaceae / Q000737:chemistry*; D014343:Trypan Blue / Q000032:analysis
chemical_list: D044946:Biflavonoids; D005419:Flavonoids; D010936:Plant Extracts; C038044:baicalin; D000431:Ethanol; D014343:Trypan Blue