title: Late-onset Leclercia adecarboxylata bacteraemia in a premature infant in the NICU.
abstract: Late-onset sepsis is a unique entity in the neonatal intensive care unit (NICU), as organisms involved are, by definition, nosocomial. As such, a limited number of microbes are characteristically involved. Leclercia adecarboxylata is a gram-negative bacillus rarely cultured in a clinical context, with the few published cases primarily involving immunocompromised adults. We present an ex-26-week newborn girl who developed late-onset sepsis with Leclercia adecarboxylata bacteraemia in the NICU. The infection was successfully treated with gentamicin and cefotaxime. This is the fifth paediatric report of Leclercia adecarboxylata infection, and the first in a neonate. The case raises the possibility that prior courses of antibiotics may have predisposed this individual to a rare infection essentially limited to immunocompromised individuals.
  
  
  CONCLUSIONS
  Leclercia adecarboxylata is a rare infection, particularly in immunocompetent individuals. In neonates, the clinical course can be good with timely initiation of appropriate antibiotics.
authors.affiliation: Department of Paediatrics, Division of Neurology, University of Calgary, Alberta Children's Hospital, Canada. kmyers@ucalgary.ca
authors.forename: K A
authors.initials: KA
authors.lastname: Myers
authors.forename: R M
authors.initials: RM
authors.lastname: Jeffery
authors.forename: A
authors.initials: A
authors.lastname: Lodha
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D004755:Enterobacteriaceae / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000382:microbiology*; D007363:Intensive Care Units, Neonatal
chemical_list: D000900:Anti-Bacterial Agents