title: Genetics of sudden cardiac death.
abstract: Advances in genetic testing technology have led to a proliferation of new genetic tests and accelerated developments in the field of cardiovascular genetic medicine. These advances enhance presymptomatic diagnosis and can establish a definitive molecular diagnosis for symptomatic patients at risk for sudden cardiac death. Most importantly, genotype-phenotype correlations can add important information for predicting outcome and selecting treatment for patients with inherited arrhythmic disorders. This paper reviews the current data regarding genotype-phenotype correlations and the role of clinical genetic testing in diagnosis, prognosis, and management of inheritable disorders leading to sudden cardiac death.
authors.affiliation: Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, NY 14642, USA. alon.barsheshet@heart.rochester.edu
authors.forename: Alon
authors.initials: A
authors.lastname: Barsheshet
authors.forename: Andrew
authors.initials: A
authors.lastname: Brenyo
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Moss
authors.forename: Ilan
authors.initials: I
authors.lastname: Goldenberg
mesh_terms: D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000175:diagnosis / Q000235:genetics; D053840:Brugada Syndrome / Q000175:diagnosis / Q000235:genetics; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000235:genetics; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000235:genetics; D004252:DNA Mutational Analysis; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006331:Heart Diseases / Q000150:complications / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008133:Long QT Syndrome / Q000175:diagnosis / Q000235:genetics; D008297:Male; D009154:Mutation; D011379:Prognosis; D012307:Risk Factors; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000235:genetics