title: Chemoenzymatic dynamic kinetic resolution of primary amines catalyzed by CAL-B at 38-40 °C.
abstract: The (R)-selective chemoenzymatic dynamic kinetic resolution of primary amines was performed at 38-40 °C in MTBE, in good to high yields and with high enantiomeric excesses. These reactions associating CAL-B to octanethiol as radical racemizing agent were carried out in the presence of methyl β-methoxy propanoate as acyl donor, under photochemical irradiation at 350 nm in glassware.
authors.affiliation: Equipe Chimie Moléculaire Organique, LCP UMR 6264, Boite 562, Université Aix-Marseille, Faculté des Sciences St Jérôme, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Poulhès
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vanthuyne
authors.forename: Michèle P
authors.initials: MP
authors.lastname: Bertrand
authors.forename: Stéphane
authors.initials: S
authors.lastname: Gastaldi
authors.forename: Gérard
authors.initials: G
authors.lastname: Gil
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D005656:Fungal Proteins; D007700:Kinetics; D008049:Lipase / Q000737:chemistry*; D015394:Molecular Structure; D013696:Temperature
chemical_list: D000588:Amines; D005656:Fungal Proteins; D008049:Lipase; C431349:lipase B, Candida antarctica