title: Functional biomarkers for neurodegenerative disorders based on the network paradigm.
abstract: This commentary provides a brief introduction to the various uses that functional neuroimaging biomarkers can play in detecting, diagnosing, assessing treatment response and investigating neurodegenerative disorders. It then goes on to explain why the emphasis of much recent work has shifted to network-based biomarkers, as opposed to those that examine individual brain regions. A number of examples are referenced that illustrate the points made.
authors.affiliation: Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg. 10, Rm. 5D39, 10 Center Drive, MSC 1402, Bethesda, MD, USA. horwitzb@nidcd.nih.gov
authors.forename: Barry
authors.initials: B
authors.lastname: Horwitz
authors.forename: James B
authors.initials: JB
authors.lastname: Rowe
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology*; D001931:Brain Mapping; D006801:Humans; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D049268:Positron-Emission Tomography
chemical_list: D015415:Biomarkers