title: Limb regeneration: a new development?
abstract: Salamander limb regeneration is a classical model of tissue morphogenesis and patterning. Through recent advances in cell labeling and molecular analysis, a more precise, mechanistic understanding of this process has started to emerge. Long-standing questions include to what extent limb regeneration recapitulates the events observed in mammalian limb development and to what extent are adult- or salamander- specific aspects deployed. Historically, researchers studying limb development and limb regeneration have proposed different models of pattern formation. Here we discuss recent data on limb regeneration and limb development to argue that although patterning mechanisms are likely to be similar, cell plasticity and signaling from nerves play regeneration-specific roles.
authors.affiliation: DFG-Center for Regenerative Therapies Dresden, Germany. eugeniu.nacu@crt-dresden.de
authors.forename: Eugen
authors.initials: E
authors.lastname: Nacu
authors.forename: Elly M
authors.initials: EM
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D004625:Embryo, Nonmammalian / Q000033:anatomy & histology / Q000502:physiology; D005121:Extremities / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D009024:Morphogenesis / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014562:Caudata / Q000033:anatomy & histology* / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins