title: FBXW5 controls centrosome number.
abstract: Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication.
authors.forename: Julia
authors.initials: J
authors.lastname: Pagan
authors.forename: Michele
authors.initials: M
authors.lastname: Pagano
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D002502:Centrioles / Q000502:physiology; D018385:Centrosome / Q000502:physiology*; D044783:F-Box Proteins / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology
chemical_list: D018797:Cell Cycle Proteins; D044783:F-Box Proteins; C528759:FBXW5 protein, human; C497202:SASS6 protein, human; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; C490219:PLK4 protein, human; D017346:Protein Serine-Threonine Kinases