title: Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa.
abstract: We investigated the microbial conversion of curcumin (1) using endophytic fungi associated with the rhizome of Curcuma longa (Zingiberaceae). We found that Diaporthe sp., an endophytic filamentous fungus, converts curcumin (1) into four colorless derivatives, namely (3R,5R)-tetrahydrocurcumin (2), a novel (3R,5S)-hexahydrocurcumin (3) named neohexahydrocurcumin, (3S,5S)-octahydrocurcumin (4) and meso-octahydrocurcumin (5).
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Maehara
authors.forename: Michiteru
authors.initials: M
authors.lastname: Ikeda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Haraguchi
authors.forename: Chinami
authors.initials: C
authors.lastname: Kitamura
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Nagoe
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ohashi
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D001203:Ascomycota / Q000737:chemistry / Q000378:metabolism*; D030024:Curcuma / Q000382:microbiology*; D003474:Curcumin / Q000031:analogs & derivatives* / Q000378:metabolism*; D027343:Rhizome / Q000382:microbiology*
chemical_list: D003474:Curcumin