title: Clinical and molecular aspects of malaria fever.
abstract: Although clinically benign, malaria fever is thought to have significant relevance in terms of parasite growth and survival and its virulence which in turn may alter the clinical course of illness. In this article, the historical literature is reviewed, providing some evolutionary perspective on the genesis and biological relevance of malaria fever, and the available molecular data on the febrile-temperature-inducible parasite factors that may contribute towards the regulation of parasite density and alteration of virulence in the host is also discussed. The potential molecular mechanisms that could be responsible for the induction and regulation of cyclical malaria fevers caused by different species of Plasmodium are also discussed.
authors.affiliation: Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA.
authors.forename: Miranda S
authors.initials: MS
authors.lastname: Oakley
authors.forename: Noel
authors.initials: N
authors.lastname: Gerald
authors.forename: Thomas F
authors.initials: TF
authors.lastname: McCutchan
authors.forename: L
authors.initials: L
authors.lastname: Aravind
authors.forename: Sanjai
authors.initials: S
authors.lastname: Kumar
mesh_terms: D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology; D005334:Fever / Q000209:etiology* / Q000469:parasitology / Q000503:physiopathology; D005786:Gene Expression Regulation; D017261:Glycosylphosphatidylinositols / Q000378:metabolism*; D018869:Heat-Shock Response; D006420:Hemeproteins / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000469:parasitology / Q000503:physiopathology; D008288:Malaria / Q000150:complications* / Q000469:parasitology; D018512:Parasitemia / Q000150:complications / Q000469:parasitology; D010961:Plasmodium / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D015398:Signal Transduction; D014774:Virulence
chemical_list: D017261:Glycosylphosphatidylinositols; D006420:Hemeproteins; C020753:hemozoin