title: Diagnostic value of amplitude-integrated electroencephalogram in neonatal seizures.
abstract: OBJECTIVE To investigate the accuracy of amplitude-integrated electroencephalography (aEEG) in detecting full-term neonatal seizures. METHODS Conventional EEG (cEEG) and aEEG were simultaneously applied to 62 full-term newborns with seizures and results were analyzed with different methods. RESULTS Of 876 seizures confirmed by cEEG, 21% were detected by clinical observation, 44.4% by aEEG and 85.7% by aEEG plus C3/C4 raw EEG. Of 531 seizures with a frequency higher than 5 times/h, 52.5% were detected by aEEG and 96.8% by aEEG plus C3/C4 raw EEG. Of 510 seizures lasting longer than 60 s, 50.6% were diagnosed by aEEG and 84.1% by aEEG plus C3/C4 raw EEG. Of 509 seizures originating in the central region, 57.9% were detected by aEEG and 90.9% by aEEG plus C3/C4 raw EEG. CONCLUSION Combination of aEEG with cEEG offers more accurate diagnosis, especially for detecting high-frequency, long-lasting and central region-generated seizures.
authors.affiliation: Department of Pediatrics, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China. zhliande@gmail.com
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Zhou
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Chang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Luo
mesh_terms: D058256:Brain Waves / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011237:Predictive Value of Tests; D012640:Seizures / Q000175:diagnosis* / Q000503:physiopathology*