title: Effects of flour bleaching agent on mice liver antioxidant status and ATPases.
abstract: Benzoyl peroxide (BPO) is a strong oxidizing agent and widely used as flour bleaching agent. However their potential risk of liver damage is unknown. The aim of this study was to investigate the effects of BPO on mice liver antioxidant status and ATPases according to the actual amount of BPO in flour from Jinan, China. The results showed that the maximum concentration of BPO reached up to 284.6 mg/kg and content of BPO mainly ranged from 0 to 240 mg/kg. Therefore, four groups of mice were gavaged daily with BPO at doses of 0, 50, 100, 200mg/kg b.w./d for 42 days, respectively. In liver tissue, superoxide dismutase (SOD) activity was significantly decreased, while the content of malondialdehyde (MDA) significantly increased following BPO exposure at 200mg/kg b.w. BPO significantly decreased the Mg(2+)-ATPase and Ca(2+)-ATPase activities of the liver at 200mg/kg b.w. BPO, at all of the doses assayed, produced non-significant effects on glutathione peroxidase (GSH-Px) and Na(+)K(+)-ATPase activities. Experimental results suggested that BPO had certain adverse effects on antioxidant status and the activities of Mg(2+)-ATPase and Ca(2+)-ATPase of liver tissue.
authors.affiliation: Department of Sanitary Inspection, School of Public Health, Shangdong University, 44 Western Wenhua Road, Jinan 250012, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Jia
authors.forename: Yangxinwei
authors.initials: Y
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001585:Benzoyl Peroxide / Q000633:toxicity*; D015415:Biomarkers; D057886:Bleaching Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005433:Flour / Q000032:analysis*; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D016877:Oxidants / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D057886:Bleaching Agents; D016877:Oxidants; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000251:Adenosine Triphosphatases; D001585:Benzoyl Peroxide