title: Contributions of intestinal bacteria to nutrition and metabolism in the critically ill.
abstract: Important advances in the study of bacteria associated with the human gastrointestinal tract have significant implications for clinicians striving to meet the metabolic and nutritional needs of critically ill patients. This article offers a broad overview of the importance of the host-microbe relationship, discusses what is currently known about the role of gut microbes in nutrition and metabolism in the healthy human host, reviews how gut microbes are affected by critical illness, and discusses interventions that have already been used to manipulate the gut microbiome in patients in the intensive care unit.
authors.affiliation: Division of Pediatric General and Thoracic Surgery, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC, Faculty Pavilion 7th Floor, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Morowitz
authors.forename: Erica M
authors.initials: EM
authors.lastname: Carlisle
authors.forename: John C
authors.initials: JC
authors.lastname: Alverdy
mesh_terms: D000818:Animals; D001419:Bacteria / Q000302:isolation & purification / Q000378:metabolism*; D016638:Critical Illness; D004040:Dietary Carbohydrates / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism; D005215:Fasting; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D050356:Lipid Metabolism; D009752:Nutritional Status; D009765:Obesity / Q000382:microbiology; D014815:Vitamins / Q000378:metabolism
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D014815:Vitamins