title: Drosophila: a fruitful model for calcium oxalate nephrolithiasis?
abstract: Even though the prevalence of nephrolithiasis is increasing, our understanding of the pathophysiology has not kept pace and new therapeutic approaches have not emerged. The potential of a new physiological model (the fruitfly) is exciting. The model has strengths, namely the low cost of maintaining colonies and rapid deployment of new transgenic lines, but also weaknesses that may ultimately limit its usefulness, such as the mechanism of tubular fluid formation and difficulties in following plasma and urine biochemistries.
authors.affiliation: Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8029, USA.
authors.forename: Felix
authors.initials: F
authors.lastname: Knauf
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Preisig
mesh_terms: D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D019855:Ethylene Glycol; D005260:Female; D008297:Male; D008317:Malpighian Tubules / Q000378:metabolism*; D053040:Nephrolithiasis / Q000378:metabolism*; D052878:Urolithiasis / Q000378:metabolism*
chemical_list: D002129:Calcium Oxalate; D019855:Ethylene Glycol