title: Erythrocyte acetylcholinesterase activity as a surrogate indicator of lead-induced neurotoxicity in occupational lead exposure in Abeokuta, Nigeria.
abstract: Dose-effect and dose-response relationships in occupational neurotoxicology are rarely studied by means of biochemical methods. In order to investigate the potential neurotoxic effects of lead during occupational exposure to this metal, the activity of erythrocyte acetylcholinesterase (AcChE), as well as blood pressure and pulse, were determined in various artisans in Abeokuta, Nigeria, who have been shown to be occupationally exposed to lead, and these were related to blood lead levels. AcChE activity in the artisans was inhibited to varying extents. While AcChE activity was inhibited to the tune of 39% in the male petrol station attendants, the inhibition amounted to 32% in female petrol station attendants. In other artisans, AcChE inhibition ranged from 31% in the welders to 38% in painters. The lowest inhibition of 15% was obtained in the panel beaters. Correlations, as calculated by Pearson's method, revealed a significant (p<0.001) inverse linear relationship between AcChE activity and blood lead levels (r=-0.40; y=-120.38x+13935.59; p<0.001). Blood pressure and pulse were not significantly different between control and lead-exposed subjects. Our findings suggest that erythrocyte AcChE activity could be used as a biomarker of lead-induced neurotoxicity in occupationally exposed subjects.
authors.affiliation: Department of Biochemistry, University of Agriculture, Abeokuta, Nigeria; Toxicokinetics Section, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow 226001, India.
authors.forename: O
authors.initials: O
authors.lastname: Ademuyiwa
authors.forename: R N
authors.initials: RN
authors.lastname: Ugbaja
authors.forename: S O
authors.initials: SO
authors.lastname: Rotimi
authors.forename: E
authors.initials: E
authors.lastname: Abam
authors.forename: B S
authors.initials: BS
authors.lastname: Okediran
authors.forename: O A
authors.initials: OA
authors.lastname: Dosumu
authors.forename: B O
authors.initials: BO
authors.lastname: Onunkwor