title: Emerging evidence of the health benefits of S-equol, an estrogen receptor β agonist.
abstract: Many clinical studies have been carried out to determine the health benefits of soy protein and the isoflavones contained in soy. S-equol is not present in soybeans but is produced naturally in the gut of certain individuals, particularly Asians, by the bacterial biotransformation of daidzein, a soy isoflavone. In those intervention studies in which plasma S-equol levels were determined, a concentration of >5-10 ng/mL has been associated with a positive outcome for vasomotor symptoms, osteoporosis (as measured by an increase in bone mineral density), prostate cancer, and the cardiovascular risk biomarkers low-density lipoprotein cholesterol and C-reactive protein. These studies suggest that S-equol may provide therapeutic benefits for a number of medical needs.
authors.affiliation: Ausio Pharmaceuticals, LLC, Cincinnati, Ohio, USA. richard@ausiopharma.com
authors.forename: Richard L
authors.initials: RL
authors.lastname: Jackson
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Greiwe
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Schwen
mesh_terms: D015415:Biomarkers / Q000097:blood; D001711:Biotransformation; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy; D060754:Equol / Q000097:blood* / Q000378:metabolism / Q000494:pharmacology*; D047629:Estrogen Receptor beta / Q000819:agonists* / Q000378:metabolism; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology; D007529:Isoflavones / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D010024:Osteoporosis / Q000097:blood / Q000188:drug therapy; D048789:Phytoestrogens / Q000097:blood* / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D047629:Estrogen Receptor beta; D007529:Isoflavones; D008077:Lipoproteins, LDL; D048789:Phytoestrogens; D060754:Equol; C004742:daidzein; D002097:C-Reactive Protein