title: Gadolinium chelate kinetics in cardiac MR imaging of myocarditis: comparison to acute myocardial infarction and impact on late gadolinium enhancement.
abstract: OBJECTIVE
  To compare the kinetics of gadolinium in myocarditis and myocardial infarction and to establish the best interval between contrast injection and late gadolinium-enhanced (LGE) image acquisition for the diagnosis of acute myocarditis.
  
  
  METHODS
  Seventeen patients with acute myocarditis and 12 with acute myocardial infarction underwent Look-Locker sequences before and after administration of 0.2 mmol/kg gadolinium chelate for a period of 14 minutes. The apparent longitudinal relaxation rates (R'1) were calculated from left ventricular blood, enhanced and normal myocardium. LGE cardiac magnetic resonance images were acquired at 5, 10, and 15 minutes after contrast injection. The contrast between enhanced and normal myocardium (Contrastenhaced-normal) was measured, and the quality of the images was analyzed.
  
  
  RESULTS
  A faster decline in the R'1 values measured in the areas of myocardial enhancement was recorded in myocarditis than that in myocardial infarction. In myocarditis, the Contrastenhaced-normal values decreased over time (from 60.7 ± 35.1 at 5 minutes vs. 42.1 ± 26.7 at 15 minutes; P = 0.001). However, in myocardial infarction, the Contrastenhaced-normal value remained stable in time (60.7 ± 22.9 at 5 minutes vs. 68.8 ± 16.6 at 15 minutes; P = ns).
  
  
  CONCLUSIONS
  The gadolinium kinetics of acute myocarditis are different from those of acute myocardial infarction. In myocarditis, LGE images acquired 5 minutes after contrast injection provide higher Contrastenhaced-normal and better image quality compared with images taken at later points.
authors.affiliation: Department of Radiology, Université Marseille Méditerrané, Hôpital Universitaire la Timone, Marseille Cedex, France. alexis.jacquier@ap-hm.fr
authors.forename: Alexis
authors.initials: A
authors.lastname: Jacquier
authors.forename: Caroline
authors.initials: C
authors.lastname: Prost
authors.forename: Nicolas
authors.initials: N
authors.lastname: Amabile
authors.forename: Roch
authors.initials: R
authors.lastname: Giorgi
authors.forename: Antonin
authors.initials: A
authors.lastname: Flavian
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Gaubert
authors.forename: Arthur
authors.initials: A
authors.lastname: Varoquaux
authors.forename: Franck
authors.initials: F
authors.lastname: Paganelli
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Bartoli
authors.forename: Guy
authors.initials: G
authors.lastname: Moulin
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000493:pharmacokinetics*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D009205:Myocarditis / Q000175:diagnosis*; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine