title: The living-tissue microscope: the importance of studying stem cells in their natural, undisturbed microenvironment.
abstract: Advances in stem cell research highlight the importance of analysing multicellular interactions in vivo before modelling them in cell culture systems. Gain-of-function assays such as transplantation are useful, but are not equivalent to studying cells in their natural, undisturbed microenvironment.
authors.affiliation: Department of Embryology/HHMI, Carnegie Institution, Carnegie Institution, Baltimore, MD 21218, USA. spradling@ciwemb.edu
authors.forename: Allan C
authors.initials: AC
authors.lastname: Spradling
mesh_terms: D006801:Humans; D013234:Stem Cells / Q000166:cytology*; D019459:Urothelium / Q000166:cytology*