title: Optical and biometric characteristics of anisomyopia in human adults.
abstract: OBJECTIVE
  To investigate the role of higher order optical aberrations and thus retinal image degradation in the development of myopia, through the characterization of anisomyopia in human adults in terms of their optical and biometric characteristics.
  
  
  METHODS
  The following data were collected from both eyes of 15 young adult anisometropic myopes and 16 isometropic myopes: subjective and objective refractive errors, corneal power and shape, monochromatic optical aberrations, anterior chamber depth, lens thickness, vitreous chamber depth, and best corrected visual acuity. Monochromatic aberrations were analyzed in terms of their higher order components, and further analyzed in terms of 31 optical quality metrics. Interocular differences for the two groups (anisomyopes vs isomyopes) were compared and the relationship between measured ocular parameters and refractive errors also analyzed across all eyes.
  
  
  RESULTS
  As expected, anisomyopes and isomyopes differed significantly in terms of interocular differences in vitreous chamber depth, axial length and refractive error. However, interocular differences in other optical properties showed no significant intergroup differences. Overall, higher myopia was associated with deeper anterior and vitreous chambers, higher astigmatism, more prolate corneas, and more positive spherical aberration. Other measured optical and biometric parameters were not significantly correlated with spherical refractive error, although some optical quality metrics and corneal astigmatism were significantly correlated with refractive astigmatism.
  
  
  CONCLUSIONS
  An optical cause for anisomyopia related to increased higher order aberrations is not supported by our data. Corneal shape changes and increased astigmatism in more myopic eyes may be a by-product of the increased anterior chamber growth in these eyes; likewise, the increased positive spherical aberration in more myopic eyes may be a product of myopic eye growth.
authors.affiliation: Vision Science Group, University of California, Berkeley, USA.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Tian
authors.forename: Janice
authors.initials: J
authors.lastname: Tarrant
authors.forename: Christine F
authors.initials: CF
authors.lastname: Wildsoet
mesh_terms: D000293:Adolescent; D000328:Adult; D001699:Biometry; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000473:pathology* / Q000503:physiopathology; D012029:Refraction, Ocular; D012160:Retina / Q000473:pathology* / Q000503:physiopathology; D055815:Young Adult