title: Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3',4'-Di-(O)-(-)-camphanoyl-(+)-khellactone.
abstract: Optically active structural isomers (1b-f and dst-1b-f) of 3',4'-di-(O)-(-)-camphanoyl-(+)-khellactone (DCK) were synthesized and their anti-human immunodeficiency virus (HIV) activity was investigated. The value of the sensitivity index (SI) of 1b was greater than that of DCK.
authors.affiliation: Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Nishioka
authors.forename: Koji
authors.initials: K
authors.lastname: Uesugi
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ueda
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kondo
authors.forename: Megumi
authors.initials: M
authors.lastname: Tsuji
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Abe
authors.forename: Takashi
authors.initials: T
authors.lastname: Harayama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hamasaki
authors.forename: Masanori
authors.initials: M
authors.lastname: Baba
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Takeuchi
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002164:Camphor / Q000031:analogs & derivatives*; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007536:Isomerism; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D003374:Coumarins; D002164:Camphor; C520900:khellactone