title: Correlation between cytokines and anxious-depressive symptoms in patients with fibromyalgia.
abstract: OBJECTIVE
  To establish the influence of cytokines on anxious-depressive manifestations in fibromyalgia (FM) patients.
  
  
  METHODS
  The study comprised 56 women (50.5±7.8 years) with FM and 32 healthy female controls (39.65±9.24 years). Psychiatric symptoms were analyzed using the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS), while pain was assessed by means of a Visual Analog Scale (VAS). Proinflammatory cytokines IL-6, IL-8, IL-10, and TNFα were assayed in serum using the Luminex-xMAP method. The statistical analysis was carried out using the SSPS statistical package.
  
  
  RESULTS
  IL-8 values were significantly lower (p=.013) in patients than in controls. No differences were observed among IL-6, IL-10, and TNFα levels. When comparing cytokine levels with patient age, we observed a significant reduction in IL-6, IL-8, and TNFα in older patients. The values of these cytokines showed no relationship to the anxious-depressive symptoms.
  
  
  CONCLUSIONS
  In our series no differences in serum cytokines were seen between patients with FM and controls, with the exception of a reduction in IL-8 among patients with FM, and which could be attributed to the older age of these patients.
authors.affiliation: Servicio de Inmunología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
authors.forename: José-Raúl
authors.initials: JR
authors.lastname: García-Lozano
authors.forename: Carmen
authors.initials: C
authors.lastname: Capilla-Sevilla
authors.forename: Olga
authors.initials: O
authors.lastname: García-López
authors.forename: Isabel
authors.initials: I
authors.lastname: Moreno-Gallego