title: Synthesis and biological evaluation of two salidroside analogues in the PC12 cell model exposed to hypoglycemia and serum limitation.
abstract: Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, two analogues were prepared with the glucosamine and N-acetylglucosamine as glycosyl donor, 2-(4-hydroxyphenyl)ethanol as glycosyl acceptor. The effects of them over PC12 cell model exposed to hypoglycemia and serum limitation were assessed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Flow Cytometry and Western blot analysis.
authors.affiliation: Surgical Comprehensive Laboratory of Affiliated Hospital, Nantong University, China.
authors.forename: Yibing
authors.initials: Y
authors.lastname: Guo
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Li
authors.forename: Yahong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yongxing
authors.initials: Y
authors.lastname: Si
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.forename: Yumin
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007003:Hypoglycemia / Q000378:metabolism*; D016716:PC12 Cells; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D029771:Rhodiola / Q000737:chemistry*; D044967:Serum / Q000378:metabolism*
chemical_list: D005960:Glucosides; D010636:Phenols; C009172:rhodioloside