title: Oral finasteride improved the quality of life of androgenetic alopecia patients.
abstract: Although androgenetic alopecia (AGA) is not a systemic disease, some patients suffer from anxiety about the progression of their condition. This study was conducted in order to ascertain whether treatment by oral finasteride can improve the quality of life (QOL) of these patients. Twenty-seven male AGA patients aged 19-76 years (average, 33.8) answered the Visual Analog Scale (VAS), Dermatology Life Quality Index (DLQI), WHO/QOL-26 and State-Trait Anxiety Inventory (STAI) questionnaires before and after the administration of finasteride (1 mg/day) for 6 months. Patients assessed by physicians as "excellent" or "good" were defined as "high responders"; those assessed as "moderate" or "no change" were "low responders". The changes in QOL before and after the treatment were statistically analyzed, and the improved value of each QOL index of the high responders and low responders from baseline were compared. There was a statistical difference in the VAS (P < 0.0001) and DLQI (P < 0.01) indices before and after the administration of finasteride. No significant changes occurred in the WHO/QOL-26 and STAI indices. Comparison of the high responders (11 cases) and low responders (16 cases) revealed no statistical difference in the improvement of VAS and DLQI scores. Oral finasteride improves the QOL of these patients, and VAS and DLQI are useful for the evaluation of patients' QOL because of the high sensitivity of these tests. However, oral finasteride did not alleviate the patients' anxiety nor did its efficacy correlate with the level of reported anxiety.
authors.affiliation: Department of Dermatology, Tokyo Medical University, Tokyo, Japan. msyzk@tokyo-med.ac.jp
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyakura
authors.forename: Masaki
authors.initials: M
authors.lastname: Uchiyama
authors.forename: Ayako
authors.initials: A
authors.lastname: Hobo
authors.forename: Ryokichi
authors.initials: R
authors.lastname: Irisawa
authors.forename: Ryoji
authors.initials: R
authors.lastname: Tsuboi
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000008:administration & dosage; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000505:Alopecia / Q000188:drug therapy* / Q000523:psychology; D018120:Finasteride / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D058891:5-alpha Reductase Inhibitors; D018120:Finasteride