title: [Intervention of astragalus injection on the kidney injury after cardiopulmonary bypass of infants with congenital heart disease].
abstract: OBJECTIVE
  To study the intervention of astragalus injection in the kidney injury of infants with congenital heart disease after cardiopulmonary bypass, thus providing a new method for protection of the kidney injury in them.
  
  
  METHODS
  Forty infants undergoing cardiac surgery with cardiopulmonary bypass were randomly assigned to the test group and the control group, twenty in each group. Astragalus Injection (at the dose of 2 mL/kg) was added in the perfusion fluid before giving to infants in the test group before bypass, while the normal saline of the same volume was added in the perfusion fluid before giving to infants in the control group (P < 0.01). The concentrations of serum tumor necrosis factor-alpha (TNF)-alpha, interleukin-6 (IL-6), cystatin C (CysC), and N-acetyl-beta-D-glucosaminidase (NAG) were detected with ELISA at the following time points, i.e., before bypass (T1), by the end of the surgery (T2), 2 h after surgery (T3), 6 h after surgery (T4), and 24 h after surgery (T5).
  
  
  RESULTS
  The serum CysC concentrations were not significantly higher after CPB (P > 0.05). The urinary NAG level increased significantly in the control group after surgery (P < 0.05), but no obvious increase of the urinary NAG level was found in the test group after surgery (P > 0.05). It was obviously lower than that of the control group (P < 0.05). After CPB serum TNF-alpha and IL-6 levels increased significantly in the control group (P < 0.05), while they were lower in the test group than in the control group (P < 0.01).
  
  
  CONCLUSIONS
  CPB may result in the renal tubular injury in infants with congenital heart disease. The application of Astragalus Injection before the CPB plays a role in protecting renal tubular functions.
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, Children's Hospital AfFiliated to Chongqing Medical University, Chongqing.
authors.forename: Yun-xing
authors.initials: YX
authors.lastname: Ti
authors.forename: Zheng-xia
authors.initials: ZX
authors.lastname: Pan
authors.forename: Chun
authors.initials: C
authors.lastname: Wu
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D027883:Astragalus Plant; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000097:blood; D007677:Kidney Function Tests; D008297:Male; D008517:Phytotherapy; D011184:Postoperative Period; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D000118:Acetylglucosaminidase