title: Thai plants from Doi Tung: brine shrimp lethality, antioxidative activity and combination effect with L-ascorbic acid.
abstract: Methanolic extracts of 18 Thai plants from Doi Tung, the north of Thailand, were examined for brine shrimp lethality and antioxidative activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. In brine shrimp lethality, the highly toxic plant extracts were Mitrephora wangii (LC(50) 14.8 µg mL(-1)) and Hydrocotyle javanica (LC(50) 13.3 µg mL(-1)). The extracts of Sageretia cordifolia, Ulmus lancaefolia and Acer chiangdaoense exhibited highly antioxidative activities with IC(50) values of 6.7, 8.1 and 9.8 µg mL(-1), respectively. Moreover, the extracts of S. cordifolia, U. lancaefolia and A. chiangdaoense have shown slightly synergistic effects (combination index; CI < 1) with L-ascorbic acid on DPPH radicals. A number of plants demonstrated either brine shrimp lethality or free radical scavenging activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Silpakorn University, Mueang, Nakhon Pathom 73000, Thailand.
authors.forename: Patcharawan
authors.initials: P
authors.lastname: Tanamatayarat
authors.forename: Uthai
authors.initials: U
authors.lastname: Sotanaphun
authors.forename: Onoomar
authors.initials: O
authors.lastname: Poobrasert
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D003445:Crustacea / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D013785:Thailand; D018675:Toxicity Tests
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D001205:Ascorbic Acid