title: "ApoptomiRs" in vascular cells: their role in physiological and pathological angiogenesis.
abstract: MicroRNAs (miRNAs) have emerged as crucial players regulating the magnitude of gene expression in a variety of organisms. This class of short (22 nucleotides) noncoding RNA molecules have been shown to participate in almost every cellular process investigated so far, and their deregulation is observed in different human pathologies including cancer, heart disease, and neurodegeneration. These new molecular regulators have been identified also in endothelial cells (ECs), and their role in the regulation of different aspects of the angiogenic process has been recently investigated in a variety of laboratories. The current review focuses on the research progress regarding the roles of miRNAs in vascular pathology and their potential therapeutic applications for vascular diseases associated with abnormal angiogenesis, such as cancer.
authors.affiliation: Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Biotechnological Science Faculty, and IEOS, CNR Naples, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Quintavalle
authors.forename: Michela
authors.initials: M
authors.lastname: Garofalo
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Croce
authors.forename: Gerolama
authors.initials: G
authors.lastname: Condorelli
mesh_terms: D043924:Angiogenesis Modulating Agents / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000627:therapeutic use; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D035683:MicroRNAs / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D058990:Molecular Targeted Therapy; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009843:Oligoribonucleotides / Q000627:therapeutic use; D020320:Oligoribonucleotides, Antisense / Q000627:therapeutic use
chemical_list: D043924:Angiogenesis Modulating Agents; D035683:MicroRNAs; D009843:Oligoribonucleotides; D020320:Oligoribonucleotides, Antisense