title: Palladium(II)-catalyzed direct intermolecular alkenylation of chromones.
abstract: A new efficient method for the direct alkenylation of chromones via a palladium(II)-catalyzed C-H functionalization reaction was developed. The use of pivalic acid with Cu(OAc)(3)/Ag(2)CO(3) provided superior reactivity in the cross-coupling of chromones with alkene partners. This approach represents a significant advance over the existing two-step method and afforded various 3-vinylchromone derivatives, which are privileged structures in many biologically active compounds and versatile synthetic building blocks.
authors.affiliation: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Korea.
authors.forename: Donghee
authors.initials: D
authors.lastname: Kim
authors.forename: Sungwoo
authors.initials: S
authors.lastname: Hong
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D002867:Chromones / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D002867:Chromones; D010165:Palladium