title: Formaldehyde adduct to human serum albumin with reference to aspartame intake.
abstract: A preliminary study was performed to evaluate the role of formaldehyde (F) deriving from aspartame intake in the production of the adduct F-human serum albumin (F-HSA) by mean of a sera-epidemiological investigation. A blood-donors population (68 subjects) was analysed for the presence of anti-F-HSA IgG by an indirect competitive immunoenzymatic assay (displacement assay). Only the 41% of the subjects were aspartame consumer and with a low daily intake (0.96mg/(kgday)). A 50% sera-prevalence of IgG anti-F-HSA was observed in the population, but no association between this biomarker and aspartame intake was pointed out. A significant association was found between the IgG anti-F-HSA presence and exogenous F exposure sources (cigarette active smoke and occupational exposure). Considering the low number of the investigated subjects and the low doses of aspartame consumption, the results of this preliminary study seems to suggest that aspartame low intake does not influence the formation of F adducts.
authors.affiliation: Department of Public Health and Microbiology, University of Torino, Via Santena, 5bis, 10126 Torino, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gilli
authors.forename: Tiziana
authors.initials: T
authors.lastname: Schilirò
authors.forename: Deborah
authors.initials: D
authors.lastname: Traversi
authors.forename: Cristina
authors.initials: C
authors.lastname: Pignata
authors.forename: Sara
authors.initials: S
authors.lastname: Cordara
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Carraro