title: In vitro anti-malarial drug susceptibility of temperate Plasmodium vivax from central China.
abstract: In the face of recent increase of Plasmodium vivax malaria in central China, we conducted a study to evaluate in vitro susceptibility of temperate-zone P. vivax parasites to antimalarial drugs. During 2005-2006, in vitro drug susceptibility was measured for 42 clinical P. vivax isolates by using a schizont maturation inhibition technique. Geometric means of 50% inhibitory concentrations (IC(50)s) and 95% confidence intervals (CIs) were 10.87 (4.50-26.26) ng/mL for chloroquine, 4.21 (1.88-9.42-8) ng/mL for mefloquine, 11.82 (6.20-22.56) ng/mL for quinine, 0.13 (0.09-0.20) ng/mL for artesunate, 18.32 (8.08-41.50) ng/mL for pyrimethamine, and 17.73 (10.29-30.57) ng/mL for piperaquine. The IC(50) for chloroquine was lower than those obtained from isolates from Thailand and South Korea, suggesting that chloroquine remained effective against P. vivax malaria in central China. The results further indicated that temperate-zone P. vivax isolates from China were more susceptible to chloroquine, quinine, and mefloquine than isolates from Thailand.
authors.affiliation: Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lu
authors.forename: Qi
authors.initials: Q
authors.lastname: Gao
authors.forename: Kesinee
authors.initials: K
authors.lastname: Chotivanich
authors.forename: Hui
authors.initials: H
authors.lastname: Xia
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.forename: Rachanee
authors.initials: R
authors.lastname: Udomsangpetch
authors.forename: Liwang
authors.initials: L
authors.lastname: Cui
authors.forename: Jetsumon
authors.initials: J
authors.lastname: Sattabongkot
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D004351:Drug Resistance; D006801:Humans; D016780:Malaria, Vivax / Q000453:epidemiology / Q000469:parasitology; D010966:Plasmodium vivax / Q000187:drug effects*
chemical_list: D000962:Antimalarials