title: Neonatal lupus erythematosus in identical twins, showing transient bullous lesions.
abstract: One of identical twin girls was born with ulcers on her leg, and shortly after birth developed a flaccid blister on the leg. Subepidermal blister with vacuolar degeneration of basal cell layer and the heavy infiltration of mononuclear cells in the upper dermis were observed in the blister lesion. She also had generalized livedo. Her identical twin sister did not exhibit ulcers or blisters, but was born with milia on her limbs. Their mother was found to have lupus erythematosus with positive anti-Ro/SSA antibodies and developed Sjögren syndrome. We emphasize neonatal blistering and congenital milia unique manifestations of neonatal lupus erythematosus.
authors.affiliation: Department of Dermatology, Kochi Medical School, Kochi University, Okohcho, Nankoku, Kochi, Japan. nakajimk@kochi-u.ac.jp
authors.forename: Kimiko
authors.initials: K
authors.lastname: Nakajima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wakiguchi
authors.forename: Hajime
authors.initials: H
authors.lastname: Kodama
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Sano
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001768:Blister / Q000175:diagnosis* / Q000276:immunology; D004200:Diseases in Twins / Q000097:blood / Q000276:immunology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007871:Leg Ulcer / Q000175:diagnosis / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D054068:Livedo Reticularis / Q000175:diagnosis / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000151:congenital* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D020733:RNA, Small Cytoplasmic / Q000276:immunology; D012075:Remission, Spontaneous; D012261:Ribonucleoproteins / Q000276:immunology; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D016896:Treatment Outcome; D014430:Twins, Monozygotic; D000099207:SS-A Antigen
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D005938:Glucocorticoids; D008775:Methylprednisolone; D011239:Prednisolone; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; C116006:RO60 protein, human; D000099207:SS-A Antigen