title: [Myeloma bone disease and RANKL signaling].
abstract: Multiple myeloma develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. Myeloma cells produce a variety of cytokines including MIP-1 to stimulate bone resorption by enhancing RANKL expression, and suppress bone formation by inhibiting osteoblast differentiation, leading to bone destruction and rapid loss of bone. The emerging role of the RANKL/RANK signaling axis provide a molecular rationale for consideration of targeting RANKL/RANK in a bone disease in myeloma. Given formation of vicious cycle between bone destruction and tumor progression, inhibiting RANKL signaling may also contribute to the suppression of myeloma expansion.
authors.affiliation: Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abe
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D001862:Bone Resorption / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D000069448:Denosumab; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000502:physiology; D058990:Molecular Targeted Therapy; D009101:Multiple Myeloma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D010006:Osteoblasts / Q000166:cytology; D010010:Osteoclasts / Q000166:cytology; D053245:RANK Ligand / Q000276:immunology / Q000502:physiology* / Q000627:therapeutic use; D012097:Repressor Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D019402:Macrophage Inflammatory Proteins; D053245:RANK Ligand; D012097:Repressor Proteins; D016212:Transforming Growth Factor beta; C485569:WIF1 protein, human; D000069448:Denosumab