title: Spectrofluorimetric determination of DL-N-methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine in pharmaceuticals and chitosan solution.
abstract: A spectrofluorimetric method for the determination of D,L-N-methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, fluoxetine (F), in pharmaceuticals was evaluated in the 50.0-500.0 μg ml⁻¹ range. Linearity, sensibility, quantification and detection limit, and precision values are satisfactory. The method does not need pre-treatment and was successfully applied to the determination in pharmaceuticals and chitosan (Ch) solution. Ch has an ability to carry and absorb fat and may eventually be used together with F in slimming diets, and then interactions of Ch-F may occur. This work seeks to study these interactions by monitoring the photophysics of a drug in the presence of Ch. The results warn about the care that must be taken when both compounds are prescribed together.
authors.affiliation: Universidade Federal Fluminense, Polo Universitário de Rio das Ostras , Rio das Ostras, RJ, Brazil. maira.rodrigues@bol.com.br
authors.forename: Máira Regina
authors.initials: MR
authors.lastname: Rodrigues
mesh_terms: D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D004038:Diet, Reducing; D004041:Dietary Fats / Q000378:metabolism*; D004347:Drug Interactions; D005473:Fluoxetine / Q000737:chemistry* / Q000302:isolation & purification*; D000960:Hypolipidemic Agents / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D004041:Dietary Fats; D000960:Hypolipidemic Agents; D005473:Fluoxetine; D048271:Chitosan