title: Pre-treatment with mild metal exposure suppresses the neurotoxicity on locomotion behavior induced by the subsequent severe metal exposure in Caenorhabditis elegans.
abstract: Adaptive response to neurotoxicity on locomotion behavior by severe metal exposure was investigated in Caenorhabditis elegans. Exposure to 2.5μM of metals induced a moderate but significant reduction of locomotion behavior and induction of hsp-16.2::gfp expression. After pre-exposure to 2.5μM of metals, the reduced locomotion behavior induced by subsequent 50 and 100μM of metal exposure were significantly prevented, and the induction of hsp-16.2::gfp expression caused by subsequent 50 and 100μM of metal exposure were significantly suppressed. In contrast, after pre-exposure to 50μM examined metals, the reduced locomotion behavior induced by subsequent 50 and 100μM metal exposure were further decreased, and the noticeable induction of hsp-16.2::gfp expression caused by subsequent severe metal exposure were further enhanced. Therefore, pre-treatment with mild metal exposure can activate the adaptive response to neurotoxicity on locomotion behavior induced by subsequent severe metal exposure in nematodes.
authors.affiliation: Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Department of Genetics and Developmental Biology, Southeast University Medical School, Nanjing 210009, China.
authors.forename: Dayong
authors.initials: D
authors.lastname: Wang
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Xing