title: In vivo liver tissue mechanical properties by Transient Elastography: comparison with Dynamic Mechanical Analysis.
abstract: Understanding the mechanical properties of human liver is one of the most critical aspects of its numerical modeling for medical applications or impact biomechanics. Generally, model constitutive laws come from in vitro data. However, the elastic properties of liver may change significantly after death and with time. Furthermore, in vitro liver elastic properties reported in the literature have often not been compared quantitatively with in vivo liver mechanical properties on the same organ. In this study, both steps are investigated on porcine liver. The elastic property of the porcine liver, given by the shear modulus G, was measured by both Transient Elastography (TE) and Dynamic Mechanical Analysis (DMA). Shear modulus measurements were realized on in vivo and in vitro liver to compare the TE and DMA methods and to study the influence of testing conditions on the liver viscoelastic properties. In vitro results show that elastic properties obtained by TE and DMA are in agreement. Liver tissue in the frequency range from 0.1 to 4 Hz can be modeled by a two-mode relaxation model. Furthermore, results show that the liver is homogeneous, isotropic and more elastic than viscous. Finally, it is shown in this study that viscoelastic properties obtained by TE and DMA change significantly with post mortem time and with the boundary conditions.
authors.affiliation: University of Strasbourg, IMFS-CNRS, Strasbourg, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Chatelin
authors.forename: Jennifer
authors.initials: J
authors.lastname: Oudry
authors.forename: Nicolas
authors.initials: N
authors.lastname: Périchon
authors.forename: Laurent
authors.initials: L
authors.lastname: Sandrin
authors.forename: Pierre
authors.initials: P
authors.lastname: Allemann
authors.forename: Luc
authors.initials: L
authors.lastname: Soler
authors.forename: Rémy
authors.initials: R
authors.lastname: Willinger
mesh_terms: D000818:Animals; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D008099:Liver / Q000502:physiology*; D013552:Swine; D014783:Viscosity