title: Potential of modulating Wnt signaling pathway toward the development of bone anabolic agent.
abstract: Normal bone homeostasis is the result of a cross-talk between the anabolic axis (osteoblast differentiation) and catabolic axis (osteoclast remodeling). A disruption of this tightly regulated relationship leads to imbalanced bone turnover which ultimately results in diseases of the skeleton. Given that the majority of disease states are characterized by an inadequate renewal of osteoblasts, and the canonical wingless (Wnt) pathway is critical for their differentiation from progenitors, this represents an intriguing target for bone therapy. This mini-review focuses on the different options available for pharmaceutical enhancement of osteogenic differentiation through targeting the various proteins involved in Wnt signaling.
authors.affiliation: Institute for Regenerative Medicine, Texas A and M Health Science Center, Temple, TX 76502, USA.
authors.forename: Ulf
authors.initials: U
authors.lastname: Krause
authors.forename: Carl A
authors.initials: CA
authors.lastname: Gregory
mesh_terms: D045930:Anabolic Agents / Q000494:pharmacology*; D001842:Bone and Bones / Q000378:metabolism*; D002454:Cell Differentiation; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects; D047495:PPAR gamma / Q000037:antagonists & inhibitors / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000187:drug effects*
chemical_list: D045930:Anabolic Agents; D047495:PPAR gamma; D051153:Wnt Proteins; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3