title: TPAP-catalyzed direct oxidation of primary alcohols to carboxylic acids through stabilized aldehyde hydrates.
abstract: We present a simple, mild, and highly effective method for the direct conversion of primary alcohols to carboxylic acids. TPAP serves as the catalyst, and NMO·H(2)O plays a dual role, acting as the co-oxidant and as a reagent for aldehyde hydrate stabilization. This previously unknown stabilizing effect of geminal diols by N-oxides is the key for the efficiency of the overall transformation.
authors.affiliation: Fakultät für Chemie und Mineralogie, Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.
authors.forename: Andrea-Katharina C
authors.initials: AK
authors.lastname: Schmidt
authors.forename: Christian B W
authors.initials: CB
authors.lastname: Stark