title: Double-blinded randomized trial of preoperative antibiotics in midurethral sling procedures and review of the literature.
abstract: OBJECTIVE
  The objective of this study was to determine if prophylactic antibiotic use before midurethral sling procedures reduces infectious complications.
  
  
  METHODS
  In this double-blinded randomized trial, we compared infectious complications between women who received cefazolin and placebo before midurethral sling procedures.
  
  
  RESULTS
  The study was halted due to low rate of infectious outcomes seen at the first scheduled interim analysis. We enrolled 29 women in the cefazolin group and 30 in the placebo group. Total follow-up was 6 months (3-24 months). The groups were similar at the baseline. There was no statistically significant difference between the cefazolin and placebo groups, respectively, with respect to wound infections [1 (3.3%) and 0 (0%)], mesh exposure [0 (0%) and 1 (3.5%)], and bacteriuria [3 (10%) and 1 (3.5%)].
  
  
  CONCLUSIONS
  Because infection rates are low in both cefazolin and placebo groups, omitting preoperative antibiotics for midurethral slings may be justified.
authors.affiliation: Department of Obstetrics and Gynecology, Tufts University School of Medicine, Baystate Medical Center, 759 Chestnut Street, S-1681, Springfield, MA 01199, USA. oz.harmanli@bhs.org
authors.forename: Oz
authors.initials: O
authors.lastname: Harmanli
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Boyer
authors.forename: Stephen
authors.initials: S
authors.lastname: Metz
authors.forename: Elena
authors.initials: E
authors.lastname: Tunitsky
authors.forename: Keisha A
authors.initials: KA
authors.lastname: Jones
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods; D002437:Cefazolin / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures; D006801:Humans; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods*; D053825:Suburethral Slings; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome; D014550:Urinary Incontinence, Stress / Q000601:surgery*
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin