title: Significant association of caveolin-1 genotypes with bladder cancer susceptibility in Taiwan.
abstract: Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on pathological grade. In this case-control study, the association of Cav-1 polymorphisms with bladder cancer risk in a central Taiwanese population was investigated. Three hundred and seventy-five patients with bladder cancer and the same number of age- and gender-matched healthy controls were genotyped. There were significant differences between bladder cancer and control groups in the distributions of their genotypes (P = 1.0 x 10(-12) and 0.299) and allelic frequencies (P = 1.4 x 10(-14) and 6.2 x 10(-3)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms, respectively. As for haplotype analysis, subjects who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a decreased risk of bladder cancer compared to subjects with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotypes with smoking status on individual bladder cancer susceptibility. This is the first report providing evidence that Cav-1 was involved in bladder cancer in that the A allele of the Cav-1 G14713A is risky, the A allele of the Cav-1 T29107A is protective, and AA/TT on these two polymorphisms may be the most risky haplotype for the development of bladder cancer and may be novel useful genomic markers for early detection of bladder cancer.
authors.affiliation: Department of Urology, China Medical University Hospital, Taichung, Taiwan, Republic of China.
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
authors.forename: Chao-Hsiang
authors.initials: CH
authors.lastname: Chang
authors.forename: Ru-Yin
authors.initials: RY
authors.lastname: Tsai
authors.forename: Hwei-Chung
authors.initials: HC
authors.lastname: Wang
authors.forename: Rou-Fen
authors.initials: RF
authors.lastname: Wang
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.forename: Chun-Hsu
authors.initials: CH
authors.lastname: Yao
authors.forename: Yueh-Sheng
authors.initials: YS
authors.lastname: Chen
authors.forename: Song-Kun
authors.initials: SK
authors.lastname: Shyue
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D051242:Caveolin 1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013624:Taiwan; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D051242:Caveolin 1