title: Cytotoxic potency and induced biochemical parameters in mice serum of new furan derivatives against liver cancer cell line.
abstract: On the basis of monitoring the inhibition of the growth of human cancer cells, a series of novel furan derivatives of possessing a broader spectrum of antitumor activity and fewer toxic side effects than traditional anticancer drugs have been studied. Ten selected furan derivatives were subjected to a screening system for investigation of their antitumor potency against liver (HEPG2) cell line. Moreover, the biochemical effects of the selected furan derivatives on some enzymes such as aspartate and a lanine aminotransferases (ASTand ALT) and alkaline phosphatase (ALP), in addition to albumin, globulins, creatinine, total lipids, cholesterol, triglycerides and bilirubin in serum of mice were studied in comparison to 5-fluorouracil and doxorubicin. The antitumor activity results indicated that the selected furan derivatives showed growth of inhibition activity against the tested cell line but with varying intensities extents. Results of the biochemical investigations indicated that 5-fluorouracil and doxorubicin caused significant changes in the level of all parameters tested while treatment with the selected compounds showed slight, moderate or no significant changes.
authors.affiliation: Chemistry of Pesticides Dept., National Research Center, Dokki, Giza, Egypt.
authors.forename: Hala F
authors.initials: HF
authors.lastname: Abdel-Hamid
authors.forename: Abdelmohsen
authors.initials: A
authors.lastname: Soliman
authors.forename: Fahima M
authors.initials: FM
authors.lastname: Helaly
authors.forename: Shadia
authors.initials: S
authors.lastname: Ragab
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D005663:Furans / Q000138:chemical synthesis / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D005663:Furans; D004317:Doxorubicin; D005472:Fluorouracil