title: Common variation at 10p12.31 near MLLT10 influences meningioma risk.
abstract: To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK.
authors.forename: Sara E
authors.initials: SE
authors.lastname: Dobbins
authors.forename: Peter
authors.initials: P
authors.lastname: Broderick
authors.forename: Beatrice
authors.initials: B
authors.lastname: Melin
authors.forename: Maria
authors.initials: M
authors.lastname: Feychting
authors.forename: Christoffer
authors.initials: C
authors.lastname: Johansen
authors.forename: Ulrika
authors.initials: U
authors.lastname: Andersson
authors.forename: Thomas
authors.initials: T
authors.lastname: Brännström
authors.forename: Johannes
authors.initials: J
authors.lastname: Schramm
authors.forename: Bianca
authors.initials: B
authors.lastname: Olver
authors.forename: Amy
authors.initials: A
authors.lastname: Lloyd
authors.forename: Yussanne P
authors.initials: YP
authors.lastname: Ma
authors.forename: Fay J
authors.initials: FJ
authors.lastname: Hosking
authors.forename: Stefan
authors.initials: S
authors.lastname: Lönn
authors.forename: Anders
authors.initials: A
authors.lastname: Ahlbom
authors.forename: Roger
authors.initials: R
authors.lastname: Henriksson
authors.forename: Minouk J
authors.initials: MJ
authors.lastname: Schoemaker
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Hepworth
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Mühleisen
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Susanne
authors.initials: S
authors.lastname: Moebus
authors.forename: Lewin
authors.initials: L
authors.lastname: Eisele
authors.forename: Michael
authors.initials: M
authors.lastname: Kosteljanetz
authors.forename: Kenneth
authors.initials: K
authors.lastname: Muir
authors.forename: Anthony
authors.initials: A
authors.lastname: Swerdlow
authors.forename: Matthias
authors.initials: M
authors.lastname: Simon
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008579:Meningioma / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C092513:MLLT10 protein, human; D014157:Transcription Factors