title: [Human parvovirus B19 infection in sickle cell anemia patient in Mali: a case-control study].
abstract: Human parvovirus B19 (HP-19) is the only Parvoviridae known to be pathogenic in human. Studies of HP-19 infection and its associated life-threatening complications in sickle cell anemia patients have been reported in Europe and the US. These results justify the development of HP-B19 prevention and strategies to reduce the incidence of severe and life-threatening complications associated with the infection in patients with sickle cell anemia, particularly in sub-Saharan Africa where the sickle cell anemia burden is high. In light of these considerations, we conducted a case-control study including 163 patients with sickle cell anemia and 163 controls. HP-B19 diagnosis was based on the detection of IgG and IgM antibodies specific for HP-B19 using commercially available enzyme immunoassays. Anti-human parvovirus B19 IgG antibodies were found in 105 of 193 (64.8%) patients vs 79 of 193 controls (48.4%). IgM antibodies were found at a higher frequency in sickle cell anemia patients than in controls. This higher frequency was found to be age-dependent. However, the reticulocyte count showed no significant decrease in Malian patients with sickle cell anemia. Further studies are needed to better characterize the implication of HP-B19 infection in sickle cell anemia mortality and morbidity and to develop preventive strategies and efficient management of the resulting complications.
authors.affiliation: Centre de recherche et de lutte contre la drépanocytose, 03, commune III, BP 186, Bamako 03, Mali. dadiallo@icermali.org
authors.forename: D-A
authors.initials: DA
authors.lastname: Diallo
authors.forename: A
authors.initials: A
authors.lastname: Guindo
authors.forename: A
authors.initials: A
authors.lastname: Dorie
authors.forename: N
authors.initials: N
authors.lastname: Djibo
authors.forename: E
authors.initials: E
authors.lastname: Algiman
authors.forename: O-D
authors.initials: OD
authors.lastname: Ouane
authors.forename: A-A
authors.initials: AA
authors.lastname: Diakité
authors.forename: F-F
authors.initials: FF
authors.lastname: Traoré
authors.forename: M
authors.initials: M
authors.lastname: Ag Baraika
authors.forename: A-K
authors.initials: AK
authors.lastname: Dembélé
authors.forename: G
authors.initials: G
authors.lastname: Tchernia
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D000914:Antibodies, Viral / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008302:Mali / Q000453:epidemiology; D010322:Parvoviridae Infections / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D016732:Parvovirus B19, Human / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M