title: Young adults with SCD in US children's hospitals: are they different from adolescents?
abstract: BACKGROUND
  The period of transition from pediatric to adult care is a vulnerable time for patients with sickle cell disease (SCD). The optimal time for transition is unknown and there is no standard of care regarding this timing in the United States.
  
  
  METHODS
  We collected administrative data from the Pediatric Health Information System for all SCD admissions from 2000 to 2009. We compared reasons for hospitalization and resulting charges in adolescents (13-17 years) and young adults (18-21 years).
  
  
  RESULTS
  We identified 25,371 admissions of adolescents (n = 18,299) and young adults (n = 7,072) with SCD. Median admissions per patient per year was higher in young adults (0.6) compared to adolescents (0.2, P < 0.001), but reasons for hospitalization were similar between the two age groups. Complications of adult SCD such as nephropathy and pulmonary hypertension were rare (<2.5% of discharges) but more frequent in older patients (P = 0.001). Although length of stay was similar between the two groups (median = 4 days), young adults tended to incur higher charges (median +$1,314, P < 0.001) and were less likely to utilize private insurance (P < 0.001). Deaths (0.2% of admissions) were rare and similar across age groups (P = 0.7).
  
  
  CONCLUSIONS
  In a national sample of US children's hospitals, adolescents (13-17 years) and young adults (18-21 years) with SCD had similar reasons for hospitalization and low mortality. Further studies are needed to investigate whether extending the age of transition to ≥ 21 years as a national standard may decrease morbidity and mortality, improve health-related quality of life, or increase readiness for transition in patients with SCD.
authors.affiliation: College of Medicine, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Dickerson
authors.forename: Jennifer
authors.initials: J
authors.lastname: Klima
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Rhodes
authors.forename: Sarah H
authors.initials: SH
authors.lastname: O'Brien
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000401:mortality; D005260:Female; D017048:Health Care Costs; D006760:Hospitalization / Q000706:statistics & numerical data; D006776:Hospitals, Pediatric; D006801:Humans; D007902:Length of Stay; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult