title: The link between major histocompatibility complex antibodies and cell proliferation.
abstract: Experimental evidence indicates that donor-specific antibodies targeting major histocompatibility complex classes I and II molecules can elicit the key features of transplant vasculopathy by acting on the graft vasculature in 3 ways: directly activating proliferative, prosurvival, and migratory signaling in the target endothelial and smooth muscle cells; increasing expression of mitogenic factors in vascular endothelial cells, creating a potential proliferative autocrine loop; and promoting recruitment of inflammatory cells that produce mitogenic factors and elicit chronic inflammation, proliferation, and fibrosis. Here, we review the experimental literature showing the complement and Fc-independent effects of major histocompatibility complex classes I and II antibodies on graft vascular cells that may directly contribute to the proliferative aspect of transplant vasculopathy.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-1652, USA.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Valenzuela
authors.forename: Elaine F
authors.initials: EF
authors.lastname: Reed
mesh_terms: D000818:Animals; D000906:Antibodies / Q000502:physiology*; D049109:Cell Proliferation; D003165:Complement System Proteins / Q000502:physiology*; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology*; D009131:Muscle, Smooth, Vascular / Q000276:immunology* / Q000473:pathology*; D016377:Organ Transplantation; D015398:Signal Transduction
chemical_list: D000906:Antibodies; D003165:Complement System Proteins