title: Hypoglycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase.
abstract: The various fractions of the barks of Cyclocarya paliurus were systematically tested for hypoglycemic effects in alloxan-induced diabetic rats. The results showed that the chloroform fraction of the 75% EtOH extract of the barks of this plant exhibited significant blood sugar reducing activity, most of which were significantly higher than that of positive-drug metformin hydrochloride. A new compound, together with nine known compounds, was isolated from the most active fraction. The structure elucidation was based on spectroscopic methods, including two-dimensional NMR experiments (¹H-¹H COSY, HMQC, and HMBC). All of the isolates were evaluated for their α-glycosidase and glycogen phosphorylase inhibitory activities.
authors.affiliation: Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China), School of Environment and Resource of Guangxi Normal University, Guilin 541004, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Xin-Lan
authors.initials: XL
authors.lastname: Guan
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Deng
authors.forename: Lu-Qing
authors.initials: LQ
authors.lastname: Li
authors.forename: Mao-Tong
authors.initials: MT
authors.lastname: Tang
authors.forename: Ji-Guo
authors.initials: JG
authors.lastname: Huang
authors.forename: Zi-Zhan
authors.initials: ZZ
authors.lastname: Chen
authors.forename: Rui-Yun
authors.initials: RY
authors.lastname: Yang
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005959:Glucosidases / Q000037:antagonists & inhibitors; D024981:Glycogen Phosphorylase / Q000037:antagonists & inhibitors*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D029525:Juglandaceae / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008687:Metformin / Q000494:pharmacology; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D011919:Rats, Inbred Strains
chemical_list: C570484:3-hydroxypterolactone; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D007783:Lactones; D010936:Plant Extracts; D008687:Metformin; D024981:Glycogen Phosphorylase; D005959:Glucosidases