title: [Antithrombotic and hemorrhagic activities of fucoidan isolated from Fucus evanescens brown algae].
abstract: The antithrombotic and hemorrhagic activities of fucoidan with molecular weight within 20 - 40 kD isolation from Fucus evanescens seaweed have been investigated. The antithrombin activity of fucoidan is 41 +/- 9 aIIa IU/mg and the anti-factor Oà activity is 38 +/- 8 aOà IU/mg. The antithrombin and anti-factor Oà activities of plasma, antithrombotic activity (100% prevention of formation of a blood clot observed at a dose of 10 mg/kg), and hemorrhagic activity (to a lesser degree, than that of unfractionated heparin in comparable antithrombotic activity doses) increase as the doses of fucoidan increases from 2.5 to 10 mg/kg at intravenous injection in rats.
authors.forename: N N
authors.initials: NN
authors.lastname: Drozd
authors.forename: N T
authors.initials: NT
authors.lastname: Miftakhova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Savchik
authors.forename: T B
authors.initials: TB
authors.lastname: Kalinina
authors.forename: V A
authors.initials: VA
authors.lastname: Makarov
authors.forename: T I
authors.initials: TI
authors.lastname: Imbs
authors.forename: T N
authors.initials: TN
authors.lastname: Zviagintseva
authors.forename: T A
authors.initials: TA
authors.lastname: Kuznetsova
authors.forename: N N
authors.initials: NN
authors.lastname: Besednova
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage* / Q000302:isolation & purification; D000991:Antithrombins / Q000008:administration & dosage* / Q000302:isolation & purification; D004305:Dose-Response Relationship, Drug; D065427:Factor Xa Inhibitors; D044645:Fucus / Q000737:chemistry; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000008:administration & dosage; D007275:Injections, Intravenous; D008297:Male; D011134:Polysaccharides / Q000008:administration & dosage* / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D013917:Thrombin / Q000037:antagonists & inhibitors*; D013927:Thrombosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D065427:Factor Xa Inhibitors; D011134:Polysaccharides; D006493:Heparin; C007789:fucoidan; D013917:Thrombin