title: Bioactive saponins from the fruits of Aesculus pavia L.
abstract: Continued chemical investigation on the fruits of Aesculus pavia L. resulted in theisolation and identification of two new oleanolic acid saponins, namely vaccaroside A (1) andvaccaroside B (2). The isolated furostanol saponins were evaluated for cytotoxic activity againsthuman normal amniotic and human lung carcinoma cell lines using neutral red and MTT assays.In vitro experiments showed significant cytotoxicity in a dose dependent manner with IC₅₀ valuesin the range of 27.80-79.02 μM.
authors.affiliation: Branch hospital in Fengxian of Shanghai No. 6 people's hospital, Shanghai 201400, PR China
authors.forename: Zhen-Liang
authors.initials: ZL
authors.lastname: Sun
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.forename: Ai-Hong
authors.initials: AH
authors.lastname: Wan
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
mesh_terms: D031319:Aesculus / Q000737:chemistry*; D000653:Amniotic Fluid; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002460:Cell Line; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; C423333:vaccaroside A; C570488:vaccaroside B; D009828:Oleanolic Acid