title: [Management of difficult situations in patients with RA: Cancer].
abstract: Rheumatoid arthritis (RA) patients have a higher risk of developing some types of cancer, such as lymphoma or lung cancer. The severity of the disease is associated with a higher risk of developing lymphoma. Anti-TNF-α agents do not increase the incidence of neoplasm, but could trigger the onset of lymphoma in a subgroup of RA patients. Anti-TNF-α agents have been associated with a higher frequency of non-melanoma skin cancer. Although methotrexate does not increase the overall incidence of lymphoma or solid neoplasm, its use is sporadically associated with the development of lymphoma. These methotrexate-induced lymphomas occasionally disappear after withdrawal of the drug.
authors.affiliation: Servicio de Reumatología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Andréu
authors.forename: Teresa
authors.initials: T
authors.lastname: Otón
authors.forename: Jesús
authors.initials: J
authors.lastname: Sanz