title: Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles.
abstract: The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Halassa
authors.forename: Joshua H
authors.initials: JH
authors.lastname: Siegle
authors.forename: Jason T
authors.initials: JT
authors.lastname: Ritt
authors.forename: Jonathan T
authors.initials: JT
authors.lastname: Ting
authors.forename: Guoping
authors.initials: G
authors.lastname: Feng
authors.forename: Christopher I
authors.initials: CI
authors.lastname: Moore
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D001931:Brain Mapping; D000075402:Channelrhodopsins; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D021621:Imaging, Three-Dimensional; D008027:Light; D008164:Luminescent Proteins / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018613:Microscopy, Confocal; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D055096:Optical Devices; D018408:Patch-Clamp Techniques; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology*; D013787:Thalamic Nuclei / Q000166:cytology / Q000502:physiology*; D050495:Vesicular Inhibitory Amino Acid Transport Proteins / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D000075402:Channelrhodopsins; D008164:Luminescent Proteins; D050495:Vesicular Inhibitory Amino Acid Transport Proteins; C492244:Viaat protein, mouse; C054562:yellow fluorescent protein, Bacteria; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1