title: Structures of the rat complement regulator CrrY.
abstract: Complement receptor 1-related protein Y (CrrY) is an important cell-surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70° bend between domains 3 and 4. Comparisons of this structure with those of other complement regulators suggests that rearrangement of this interface may occur on forming the regulatory complex with C3b.
authors.affiliation: Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX4 3RE, England.
authors.forename: Pietro
authors.initials: P
authors.lastname: Roversi
authors.forename: Steven
authors.initials: S
authors.lastname: Johnson
authors.forename: Joseph J E
authors.initials: JJ
authors.lastname: Caesar
authors.forename: Florence
authors.initials: F
authors.lastname: McLean
authors.forename: Kirstin J
authors.initials: KJ
authors.lastname: Leath
authors.forename: Stefanos A
authors.initials: SA
authors.lastname: Tsiftsoglou
authors.forename: B Paul
authors.initials: BP
authors.lastname: Morgan
authors.forename: Claire L
authors.initials: CL
authors.lastname: Harris
authors.forename: Robert B
authors.initials: RB
authors.lastname: Sim
authors.forename: Susan M
authors.initials: SM
authors.lastname: Lea
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D051381:Rats; D011956:Receptors, Cell Surface / Q000737:chemistry*; D040681:Structural Homology, Protein
chemical_list: D000954:Antigens, Surface; C513105:Cr1l protein, rat; D011956:Receptors, Cell Surface