title: [Characteristics of Paget's disease in Spain. Data from the National Paget's Register].
abstract: OBJECTIVE
  To describe the clinical and epidemiological characteristics of patients included in the National Register of Paget's disease.
  
  
  METHODS
  A Register of patients with Paget disease (PD), radiologically confirmed, and pertaining to 25 hospitals was analysed. Clinical and epidemiological data were collected, including age, sex, date and presentations at time of diagnosis, treatment, quality of life (QL) (EuroQol 5D) and perceived health, environmental factors (profession, history of measles, contact with animals, dairy consumption, housing conditions, place of birth and address) and family history (PD history, origin of the ancestors, number of children). We conducted a statistical description of the data.
  
  
  RESULTS
  The register included 602 patients with an average age of 62±11 years and a predominance of male (55%). Of the patients included, 79% showed symptoms at the time of diagnosis, mainly pain (83%); 82% had received treatment, mainly bisphosphonates (47% more than one drug). Despite treatment, a significant proportion had limitations in their QL, especially related to pain (64%), mobility (47%) and anxiety/depression (33%). Most of the patients had been exposed to situations which were considered as risk factors. Of the patients included, 14% had family history of PD and 1.5% had children with PD. The ancestors of the familial cases came more frequently from Avila, Salamanca, La Coruña and Malaga.
  
  
  CONCLUSIONS
  The pain and the limitation of mobility decrease the QL of patients with PD despite treatment. Frequently, patients have a history of exposure to risk factors.
authors.affiliation: Sección de Reumatología, Hospital Universitario de Salamanca, RETICEF, Salamanca, España.
authors.forename: Javier
authors.initials: J
authors.lastname: Del Pino-Montes
authors.forename: M A Jesús
authors.initials: MA
authors.lastname: García de Yébenes Prous
authors.forename: Antonio
authors.initials: A
authors.lastname: Torrijos Eslava
authors.forename: Antonio
authors.initials: A
authors.lastname: Morales Piga
authors.forename: Jordi
authors.initials: J
authors.lastname: Carbonell Abelló
authors.forename: Jordi
authors.initials: J
authors.lastname: Farrerons Minguela
authors.forename: Jesús
authors.initials: J
authors.lastname: Garrido García
authors.forename: Milena
authors.initials: M
authors.lastname: Gobbo Montoya
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodríguez Pérez
authors.forename: Jesús
authors.initials: J
authors.lastname: Tornero Molina
authors.forename: Nuria
authors.initials: N
authors.lastname: Guañabens Gay
authors.forename: Loreto
authors.initials: L
authors.lastname: Carmona