title: Formylated phloroglucinols from Eucalyptus loxophleba foliage.
abstract: Two new naturally occurring formylated phloroglucinol compounds (FPCs), a dimer, loxophlebal B (10) and a cyclized FPC, loxophlebene (8) together with eight other formylated phloroglucinols (1-7 and 9) were isolated from the chloroform-methanol (8:2) extract of the leaves of Eucalyptus loxophleba ssp. lissophloia. The structures of new compounds were established by comprehensive spectral analysis and by comparison of their NMR data with those of related compounds in the literature. All the isolated compounds were evaluated for anti-leishmanial activity against promastigotes of Leishmania donovani.
authors.affiliation: Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, Punjab-160062, India.
authors.forename: Jasmeen
authors.initials: J
authors.lastname: Sidana
authors.forename: Sukhvinder
authors.initials: S
authors.lastname: Singh
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Arora
authors.forename: William J
authors.initials: WJ
authors.lastname: Foley
authors.forename: Inder Pal
authors.initials: IP
authors.lastname: Singh
mesh_terms: D005052:Eucalyptus / Q000737:chemistry*; D007893:Leishmania donovani / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D014344:Trypanocidal Agents; C570491:loxophlebal B; C570490:loxophlebene; D010696:Phloroglucinol