title: [Modern technologies for diagnostics and therapy of inflammatory intestinal diseases in children].
abstract: The paper presents currently available scientific information on epidemiology of inflammatory intestinal diseases (IID), immunogenetics, pathogenesis and new methods for diagnostics of Crohn's disease and non-specific ulcerative colitis. Results of original studies on the prevalence of polymorphous variants of different genes responsible for the development of inflammatory processes in children with these pathologies are considered. Therapeutic modalities for children with IID are discussed. Treatment with infliximab resulted in clinical remission in 82% of the children with resistant forms of IID.
authors.forename: A A
authors.initials: AA
authors.lastname: Baranov
authors.forename: A C
authors.initials: AC
authors.lastname: Potapov
authors.forename: E G
authors.initials: EG
authors.lastname: Tsymbalova
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects; D053705:Capsule Endoscopes; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D003106:Colon / Q000473:pathology; D003424:Crohn Disease / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D004334:Drug Administration Schedule; D004351:Drug Resistance; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology; D055261:Immunogenetic Phenomena; D000069285:Infliximab; D007262:Infusions, Intravenous; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism; D008991:Monitoring, Physiologic; D012074:Remission Induction; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D039841:Leukocyte L1 Antigen Complex; D000069285:Infliximab