title: New antimicrobial agents on the horizon.
abstract: Antibiotic resistance issues necessitate the continued discovery and development of new antibacterial agents. Efforts are ongoing in two approaches to find new compounds that are effective against antibiotic-resistant pathogens. These efforts involve modification of existing classes including fluoroquinolones, tetracyclines, aminoglycosides, and β-lactams and identification of inhibitors against previously unexploited antibacterial targets. Examples of both approaches are described here with emphasis on compounds in late pre-clinical or clinical stages of development.
authors.affiliation: Department of Biology, Jordan Hall, 1001 E. Third Street, Indiana University, Bloomington, IN 47405, United States. karbush@indiana.edu
authors.forename: Karen
authors.initials: K
authors.lastname: Bush
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pucci
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology / Q000502:physiology; D002473:Cell Wall / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D004269:DNA, Bacterial / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D024881:Drug Resistance, Bacterial; D005227:Fatty Acids / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000037:antagonists & inhibitors; D011500:Protein Synthesis Inhibitors / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D004269:DNA, Bacterial; D005227:Fatty Acids; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D011500:Protein Synthesis Inhibitors