title: Low central venous oxygen saturation is associated with increased mortality in critically ill dogs.
abstract: OBJECTIVE
  To investigate relationships between central venous oxygen saturation (ScvO(2)) and survival to hospital discharge in dogs. Central venous oxygen saturation is an accessible measure of the balance between systemic oxygen delivery and consumption.
  
  
  METHODS
  Prospective observational cohort study, enrolling 126 client-owned dogs with central venous catheters. Central venous oxygen saturation was measured over the 24 hours following intensive care unit admission. Poor outcome was defined as death or euthanasia performed for moribund status. Regression analysis identified independent predictors of non-survival and physiologic parameters associated with central venous oxygen saturation. Area under the receiver operator curve analysis identified a cut-off point of central venous oxygen saturation, below which central venous oxygen saturation decrease was associated with increased mortality risk.
  
  
  RESULTS
  Mortality risk was 30·9%. Low central venous oxygen saturation was associated with poor outcome (P<0·05). Area under the receiver operator curve analysis selected a central venous oxygen saturation of 68% as the point below which a fall in central venous oxygen saturation was associated with increased mortality risk. For each 10% drop in central venous oxygen saturation below 68%, odds of non-survival increased by 2·66 times (P=0·0002, 95% confidence interval of odds ratio=1·45 to 4·85). Central venous oxygen saturation was equivalent to lactate in predicting non-survival. Predictors of central venous oxygen saturation (packed cell volume, mean arterial blood pressure, fever, % arterial haemoglobin saturation as measured by pulse oximeter) were consistent with hypothesised physiologic mechanisms.
  
  
  CONCLUSIONS
  Central venous oxygen saturation was a strong mortality predictor. Further work is needed to determine if therapy targeting central venous oxygen saturation can reduce mortality in canine intensive care unit patients.
authors.affiliation: Emergency and Critical Care Medicine, University of Guelph, Ontario, Canada.
authors.forename: G M
authors.initials: GM
authors.lastname: Hayes
authors.forename: K
authors.initials: K
authors.lastname: Mathews
authors.forename: S
authors.initials: S
authors.lastname: Boston
authors.forename: C
authors.initials: C
authors.lastname: Dewey
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002405:Catheterization, Central Venous / Q000662:veterinary; D015331:Cohort Studies; D003422:Critical Care; D016638:Critical Illness / Q000401:mortality*; D004283:Dog Diseases / Q000097:blood / Q000401:mortality; D004285:Dogs / Q000097:blood*; D005260:Female; D008297:Male; D008991:Monitoring, Physiologic / Q000662:veterinary; D010092:Oximetry / Q000662:veterinary*; D010100:Oxygen / Q000032:analysis / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D010100:Oxygen