title: Effect of lithium on secretory factors and growth stimulation by bombesin in rat pancreas and salivary glands.
abstract: Lithium, a drug of choice in bipolar affective disorders, also affects the metabolism and cell proliferation in a diverse array of organisms. In this study, we investigated the effect of lithium on bombesin-mediated function in excretion and growth of the pancreas and the salivary glands. The weight, protein content, amylase concentration and salivary flow rate of the pancreas, parotid and the submandibular glands were determined in male Wistar rats after consumption of either water or lithium chloride (600 mg/l) for 14 days and each group received s.c. injection of either saline or bombesin (10 microg/kg) during the last 4 days of experiment. Our results revealed that administration of bombesin in lithium-treated group not only suppressed pancreas and parotid weight augmentation due to bombesin, but also significantly decreased pancreas growth. Chronic lithium consumption significantly inhibited the protein content augmentation due to bombesin in the salivary glands. Getting bombesin, as well as saline in lithium-treated group, resulted in notable decrease in salivary protein content. Protein content of pancreatic gland increased considerably in the bombesin-injected groups either treated with saline or lithium. In conclusion, the stimulatory effect of bombesin on the growth and protein content of the pancreas and the salivary gland was inhibited by lithium. Lithium seems to be a potent inhibitor of growth factors induced by bombesin probably through inhibiting phosphatidylinositol 4,5,bisphosphate hydrolysis.
authors.affiliation: Brain and Spinal Injury Repair Research Center, Imam Khomeini Hospital, Iran.
authors.forename: Mehrak
authors.initials: M
authors.lastname: Javadi-Paydar
authors.forename: Shahaboddin
authors.initials: S
authors.lastname: Vojdanpak
authors.forename: Maryam
authors.initials: M
authors.lastname: Pour-Ali
authors.forename: Hosein
authors.initials: H
authors.lastname: Halajian
authors.forename: Payam
authors.initials: P
authors.lastname: Ghazi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Shahsavari
authors.forename: Seyed Hasan
authors.initials: SH
authors.lastname: Emami-Razavi
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Dehpour
mesh_terms: D000681:Amylases / Q000378:metabolism*; D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D008094:Lithium / Q000097:blood / Q000494:pharmacology*; D008297:Male; D023421:Models, Animal; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D019269:Phosphatidylinositol 4,5-Diphosphate; D008094:Lithium; D000681:Amylases; D001839:Bombesin