title: Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use.
abstract: Polypropylene (PP), Polyethylene (PE) and polytetrafluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.
authors.affiliation: Department of Oral Physiology, Matsumoto Dental University Graduate School of Dentistry, Shiojiri, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tomida
authors.forename: K
authors.initials: K
authors.lastname: Nakano
authors.forename: S
authors.initials: S
authors.lastname: Matsuura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kawakami
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D005549:Foreign-Body Reaction / Q000473:pathology; D006097:Granulation Tissue / Q000473:pathology; D008297:Male; D008422:Materials Testing; D051379:Mice; D008970:Molecular Weight; D020959:Polyethylene / Q000494:pharmacology / Q000633:toxicity; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011126:Polypropylenes / Q000494:pharmacology / Q000633:toxicity; D011138:Polytetrafluoroethylene / Q000494:pharmacology / Q000633:toxicity; D019736:Prostheses and Implants / Q000009:adverse effects; D040521:Subcutaneous Tissue / Q000187:drug effects* / Q000473:pathology
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011126:Polypropylenes; D011138:Polytetrafluoroethylene; D020959:Polyethylene