title: Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients.
abstract: OBJECTIVE
  Genome wide association studies have shown an association between rs2200733 at 4q25 and atrial fibrillation (AF). In this case-control study we investigate the association of rs2200733 and lone AF in young patients.
  
  
  METHODS
  We included 196 young patients with lone AF and the first episode before the age of 40 years. We analyzed the single nucleotide polymorphism (SNP) rs2200733 for the lone AF patients and compared them to a control group of 176 age matched healthy individuals.
  
  
  RESULTS
  No significant differences, in neither genotype distribution, nor minor allele frequencies were found between the lone AF patients and the healthy controls.
  
  
  CONCLUSIONS
  Our results suggest that the rs220733 is not a risk factor for AF in patients with no other cardiovascular disease and with early onset of the arrhythmia.
authors.affiliation: Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark. Kristofferh@dadlnet.dk
authors.forename: Kristoffer M A
authors.initials: KM
authors.lastname: Henningsen
authors.forename: Morten S
authors.initials: MS
authors.lastname: Olesen
authors.forename: Stig
authors.initials: S
authors.lastname: Haunsoe
authors.forename: Jesper H
authors.initials: JH
authors.lastname: Svendsen
mesh_terms: D000328:Adult; D017668:Age of Onset; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002894:Chromosomes, Human, Pair 4; D003718:Denmark / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors