title: Hepatobiliary disorders and complications of inflammatory bowel disease.
abstract: One of typical examples of liver-gut cross talk is the interaction and impact of inflammatory bowel disease (IBD) and hepatobiliary (HB) abnormalities on each other's disease course. There are several layers of association between IBD and HB diseases: (i) HB diseases and IBD share pathogenetic mechanisms; (ii) HB diseases parallel structural and pathophysiological changes seen with IBD; and (iii) hepatic toxicity is associated with medical therapy for IBD. Interdisciplinary approach, involving gastroenterologists, hepatologists and, in advanced cases, general, colorectal, and liver transplant surgeons, is advocated.
authors.affiliation: Department of Gastroenterology/Hepatology, Digestive Disease Institute, the Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Preethi Gk
authors.initials: PG
authors.lastname: Venkatesh
authors.forename: Udayakumar
authors.initials: U
authors.lastname: Navaneethan
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
mesh_terms: D001660:Biliary Tract Diseases / Q000453:epidemiology / Q000503:physiopathology*; D015209:Cholangitis, Sclerosing / Q000453:epidemiology / Q000503:physiopathology; D015897:Comorbidity; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology*; D008107:Liver Diseases / Q000453:epidemiology / Q000503:physiopathology* / Q000601:surgery; D016031:Liver Transplantation; D016737:Proctocolectomy, Restorative