title: Anti-lipoprotein lipase antibodies in patients with hypertriglyceridemia without associated autoimmune disease.
abstract: BACKGROUND
  Anti-lipoprotein lipase antibodies have been described in rare cases of patients with hypertriglyceridemia. However, no systematic study evaluating these antibodies in patients with this lipid abnormality has been undertaken.
  
  
  OBJECTIVE
  To analyze the correlation of anti-lipoprotein lipase (anti-LPL) antibodies with other laboratory findings in patients with hypertriglyceridemia but no autoimmune disease.
  
  
  METHODS
  We evaluated 44 hypertriglyceridemic patients without autoimmune disease. Clinical and laboratory evaluations included analyses of comorbidities, fasting lipid profile and anti-LPL antibodies.
  
  
  RESULTS
  Mean patient age was 55 +/- 10 years; 46% of the patients were female and 64% were Caucasian. The mean disease duration was 94.4 months and mean body mass index 28.7 +/- 3.6 kg/m2; 34.0% were diabetic, 25.0% were obese, 72.7% had systemic arterial hypertension, 75% were sedentary, 15.9% were smokers, 56.8% had a family history of dyslipidemia, 45.5% had a family history of coronary insufficiency, 20.5% had acute myocardial infarction, 9.0% had undergone revascularization and 11.0% angioplasty, 79.5% were being treated with statins and 43.2% were taking fibrates. Median triglyceride levels were 254 mg/dl (range 100-3781 mg/dl), and total cholesterol level was 233 t 111 mg/dl. High-density lipoprotein was 42.6 +/- 15.4 mg/dl, low-density lipoprotein 110.7 +/- 42.4 mg/dl and very low-density lipoprotein 48 +/- 15 mg/dl. Anti-LPL antibodies were identified in 2 patients (4.5%), both of whom had a family history of dyslipidemia, coronary insufficiency and acute myocardial infarction; one had undergone myocardial revascularization and percutaneous transluminal coronary angioplasty, and both were using fibrates and had normal triglyceride levels.
  
  
  CONCLUSIONS
  Our findings demonstrate a correlation between the immune response and dyslipoproteinemia in hypertriglyceridemic patients, suggesting that autoimmune disease contributes to the dyslipidemia process.
authors.affiliation: Department of Rheumatology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. jotafc@gmail.com
authors.forename: Jozélio Freire
authors.initials: JF
authors.lastname: de Carvalho
authors.forename: Vilma Santos Trindade
authors.initials: VS
authors.lastname: Viana
authors.forename: Eduardo Ferreira Borba
authors.initials: EF
authors.lastname: Neto
authors.forename: Raul Dias
authors.initials: RD
authors.lastname: Santos
authors.forename: Eloísa
authors.initials: E
authors.lastname: Bonfá
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases; D015551:Autoimmunity; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000201:enzymology / Q000276:immunology*; D008071:Lipoprotein Lipase / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood*
chemical_list: D001323:Autoantibodies; D014280:Triglycerides; D008071:Lipoprotein Lipase