title: Method to quantitatively estimate wavelength-dependent scattering properties from multidiameter single fiber reflectance spectra measured in a turbid medium.
abstract: This study utilizes experimentally validated Monte Carlo simulations to identify a mathematical formulation of the reflectance intensity collected by a single fiber probe expressed in terms of the reduced scattering coefficient (μs'), fiber diameter d(fiber), and a property of the first two moments of the scattering phase function (γ). This model is then utilized to accurately obtain wavelength-dependent estimates of μs'(λ) and γ(λ) from multiple single fiber spectral measurements of a turbid medium obtained with different diameters. This method returns accurate descriptions (mean residual <3%) of both μs' and γ across the biologically relevant range.
authors.affiliation: Center for Optical Diagnostics and Therapy, Department of Radiation Oncology, Erasmus Medical Center, Rotterdam, The Netherlands. s.kanick@erasmusmc.nl
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Kanick
authors.forename: Ute A
authors.initials: UA
authors.lastname: Gamm
authors.forename: Henricus J C M
authors.initials: HJ
authors.lastname: Sterenborg
authors.forename: Dominic J
authors.initials: DJ
authors.lastname: Robinson
authors.forename: Arjen
authors.initials: A
authors.lastname: Amelink
mesh_terms: D000042:Absorption; D009010:Monte Carlo Method; D055620:Optical Phenomena; D017785:Photons; D013057:Spectrum Analysis