title: [Influence of hemantane and doxycycline on MPTP-evoked behavior violations in C57BL/6 mice].
abstract: The effects of anti-parkinsonian drug hemantane [(2-adamantyl)hexamethylenimine] (10 mg/kg, p. o.) and/or antibiotic drug doxycycline (100 mg/kg, p. o.), as well as that of neurotoxin 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine (MPTP) (4 x 20 mg/kg, i. p.) were studied in elevated plus maze test on C57BL/6 mice. On second day after injection, MPTP decreased the locomot or activity in comparison to saline. Acute administration of hemantane or doxycycline failed to influence locomotion in mice, while their combination normalized motor activity. The results obtained confirm the role of inflammatory processes in parkinsonism and suggest expediency of combined pharmacotherapy of neurodegenerative diseases.
authors.forename: G I
authors.initials: GI
authors.lastname: Kovalev
authors.forename: R M
authors.initials: RM
authors.lastname: Salimov
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000009:adverse effects; D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000818:Animals; D000978:Antiparkinson Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004318:Doxycycline / Q000008:administration & dosage*; D004338:Drug Combinations; D004357:Drug Synergism; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009498:Neurotoxins / Q000009:adverse effects; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000978:Antiparkinson Agents; D004338:Drug Combinations; D009498:Neurotoxins; C526127:hemantane; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004318:Doxycycline; D000218:Adamantane