title: Beneficial effects of the n-3 long-chain polyunsaturated fatty acids in surgical patients: updating the evidence.
abstract: The use of n-3 polyunsaturated fatty acids in surgical patients has risen by the fact that this may attenuate systemic and acute inflammatory responses secondary to surgical trauma through modulation of inflammatory mediators and cell membrane interactions. Moreover, the inclusion of n-3 fatty acids in clinical trials as part of the therapy in patients, who expect to undergo a surgical stress, suggests benefits on clinical progress. Therefore, the objective of this article is to review data from n-3 polyunsaturated fatty acid effects on biochemical parameters and on reduced length of hospitalization, number of infections, and mortality as main clinical outcomes in human surgical patients.
authors.affiliation: Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D.F., México. mariela_bernabe@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Bernabe-Garcia
authors.forename: M
authors.initials: M
authors.lastname: Lopez-Alarcón
authors.forename: F
authors.initials: F
authors.lastname: Blanco-Favela
authors.forename: J
authors.initials: J
authors.lastname: Mancilla-Ramírez
authors.forename: A
authors.initials: A
authors.lastname: Mansilla-Olivares
authors.forename: J L
authors.initials: JL
authors.lastname: Arredondo-García
mesh_terms: D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D006760:Hospitalization; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D011183:Postoperative Complications / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D013312:Stress, Physiological / Q000187:drug effects*; D013514:Surgical Procedures, Operative; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality
chemical_list: D005231:Fatty Acids, Unsaturated; D018836:Inflammation Mediators