title: The interrelated transmission of HIV-1 and cytomegalovirus during gestation and delivery in the offspring of HIV-infected mothers.
abstract: Our objective was to analyze, in formula-fed infants, correlates of HIV mother-to-child transmission, including cytomegalovirus (CMV) infection. HIV-infected infants were matched with HIV uninfected by maternal HIV RNA in a case-control design. Infant CMV infection was determined by CMV IgG at 18 months and timed by earlier CMV IgM or CMV DNA. Correlations were assessed using logistic regression. In utero HIV infection was independently associated with congenital CMV infection (P = 0.01), intrapartum HIV infection with congenital-plus-intrapartum/neonatal CMV infection (P = 0.01), and overall HIV with overall CMV infection (P = 0.001), and prematurity (P = 0.004). Congenital and acquired CMV infections are strong independent correlates of mother-to-child HIV transmission.
authors.affiliation: Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Woottichai
authors.initials: W
authors.lastname: Khamduang
authors.forename: Gonzague
authors.initials: G
authors.lastname: Jourdain
authors.forename: Wasna
authors.initials: W
authors.lastname: Sirirungsi
authors.forename: Prapaisri
authors.initials: P
authors.lastname: Layangool
authors.forename: Suparat
authors.initials: S
authors.lastname: Kanjanavanit
authors.forename: Pornsuda
authors.initials: P
authors.lastname: Krittigamas
authors.forename: Karin
authors.initials: K
authors.lastname: Pagdi
authors.forename: Rosalin
authors.initials: R
authors.lastname: Somsamai
authors.forename: Surat
authors.initials: S
authors.lastname: Sirinontakan
authors.forename: Temsiri
authors.initials: T
authors.lastname: Hinjiranandana
authors.forename: Wanna
authors.initials: W
authors.lastname: Ardonk
authors.forename: Suchat
authors.initials: S
authors.lastname: Hongsiriwon
authors.forename: Sirisak
authors.initials: S
authors.lastname: Nanta
authors.forename: Thitiporn
authors.initials: T
authors.lastname: Borkird
authors.forename: Marc
authors.initials: M
authors.lastname: Lallemant
authors.forename: Kenneth
authors.initials: K
authors.lastname: McIntosh
authors.forename: Nicole
authors.initials: N
authors.lastname: Ngo-Giang-Huong
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital / Q000635:transmission*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000151:congenital / Q000276:immunology / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D016015:Logistic Models; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D047928:Premature Birth; D012189:Retrospective Studies; D019562:Viral Load; D055815:Young Adult; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D015215:Zidovudine