title: Taraxasterane-type triterpene and neolignans from Geum japonicum Thunb. var. chinense F. Bolle.
abstract: The phytochemical investigation of the ethanolic extract of the whole plants of Geum japonicum Thunb. var. chinense F. Bolle yielded four new compounds: 20 β,28-epoxy-28-hydroxytaraxasteran-3 β-ol (1), (7R,8R)-4-hydroxy-9'-O-(α-L-rhamnopyranosyl)-3,3',5'-trimethoxy-8-O-4'-neolignan (2), (7R,8S)-4-hydroxy-9'-O-(α-L-rhamnopyranosyl)-3,3',5'-trimethoxy-8-O-4'-neolignan (3), and (7S,8S)-5-methoxycupressoside A (4), as well as 40 other known compounds. Structures were elucidated by physical, chemical, and spectroscopic methods, including 1D and 2D NMR, HRESIMS, and CD experiments. The taraxasterane-type triterpene (1) and lignans (2- 6) are reported for the first time from the GEUM genus. Moreover, all compounds were evaluated for anti-inflammatory activities against NO production in RAW264.7 macrophages, and only moderate activities were detected.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P. R. China.
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Cheng
authors.forename: Jiangjiang
authors.initials: J
authors.lastname: Qin
authors.forename: Qi
authors.initials: Q
authors.lastname: Zeng
authors.forename: Shoude
authors.initials: S
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.forename: Shikai
authors.initials: S
authors.lastname: Yan
authors.forename: Huizi
authors.initials: H
authors.lastname: Jin
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000143:Acids / Q000737:chemistry; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D002942:Circular Dichroism; D000431:Ethanol / Q000737:chemistry; D031986:Geum / Q000737:chemistry*; D006868:Hydrolysis; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000009:adverse effects; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000143:Acids; D000893:Anti-Inflammatory Agents; D017705:Lignans; D008070:Lipopolysaccharides; D014315:Triterpenes; D009569:Nitric Oxide; D000431:Ethanol