title: CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications.
abstract: C-X-C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, immune dysfunction and tumor development. CXCL10 is also recognized as a biomarker that predicts severity of various diseases. A review of the emerging role of CXCL10 in pathogenesis of infectious diseases revealed diverse roles of CXCL10 in disease initiation and progression. The potential utilization of CXCL10 as a therapeutic target for infectious diseases is discussed.
authors.affiliation: Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA. mliu@msm.edu
authors.forename: Mingli
authors.initials: M
authors.lastname: Liu
authors.forename: Shanchun
authors.initials: S
authors.lastname: Guo
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Hibbert
authors.forename: Vidhan
authors.initials: V
authors.lastname: Jain
authors.forename: Neeru
authors.initials: N
authors.lastname: Singh
authors.forename: Nana O
authors.initials: NO
authors.lastname: Wilson
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Stiles
mesh_terms: D020533:Angiogenesis Inhibitors / Q000276:immunology / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000276:immunology; D015415:Biomarkers / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000276:immunology* / Q000378:metabolism; D002633:Chemotaxis / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology* / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D054367:Receptors, CXCR3 / Q000276:immunology* / Q000378:metabolism; D012720:Severity of Illness Index
chemical_list: D020533:Angiogenesis Inhibitors; D015415:Biomarkers; C114753:CXCL10 protein, human; C515187:CXCR3 protein, human; D054357:Chemokine CXCL10; D054367:Receptors, CXCR3