title: Validation of a diagnostic microarray for human papillomavirus: coverage of 102 genotypes.
abstract: Papillomaviruses have been implicated in a variety of human diseases ranging from common warts to invasive carcinoma of the anogenital mucosa. Existing assays for genotyping human papillomavirus are restricted to a small number of types. Here, we present a comprehensive, accurate microarray strategy for detection and genotyping of 102 human papillomavirus types and validate its use in a panel of 91 anal swabs. This array has equal performance to traditional dot blot analysis with the benefits of added genotype coverage and the ability to calibrate readout over a range of sensitivity or specificity values.
authors.affiliation: Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Sarah Tuttleton
authors.initials: ST
authors.lastname: Arron
authors.forename: Peter
authors.initials: P
authors.lastname: Skewes-Cox
authors.forename: Phong H
authors.initials: PH
authors.lastname: Do
authors.forename: Eric
authors.initials: E
authors.lastname: Dybbro
authors.forename: Maria
authors.initials: M
authors.lastname: Da Costa
authors.forename: Joel M
authors.initials: JM
authors.lastname: Palefsky
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Derisi