title: [Pre-emptive ketoprofen for postoperative pain relief after urologic surgery].
abstract: BACKGROUND
  Effective multimodal postoperative analgesia is one of determinants of patient satisfaction after successful surgery. Following the recommendations of non-steroidal antiinflammatory agents (NSAIDs) for pre-emptive analgesia, we assessed the efficacy of ketoprofen administered before urological surgery.
  
  
  METHODS
  Fifty-two ASA I and II adult patients, scheduled for elective urologic procedures under general anaesthesia, were enrolled in this prospective, double blind study. They were randomized to receive intravenously either 100 mg ketoprofen or placebo (0.9% saline), one hour before the procedure, and at 8, 24, 36 and 48 h after. Pethidine was given for rescue analgesia. VAS was used for pain scoring.
  
  
  RESULTS
  Pain scores were similar in both groups and identified as severe (VAS >4) during the first 48 h after surgery. There was no difference in the number of patients requiring rescue pethidine analgesia, mostly required during the first 12 postoperative hours.
  
  
  CONCLUSIONS
  Pre-emptive analgesia with intravenous ketoprofen was ineffective in patients undergoing urological surgery.
authors.affiliation: I Klinika Anestezjologii i Intensywnej Terapii, Uniwersytet Medyczny w Lublinie. anest@umlub.pl
authors.forename: Rafał
authors.initials: R
authors.lastname: Rutyna
authors.forename: Magdalena
authors.initials: M
authors.lastname: Popowicz
authors.forename: Paweł
authors.initials: P
authors.lastname: Wojewoda
authors.forename: Andrzej
authors.initials: A
authors.lastname: Nestorowicz
authors.forename: Waldemar
authors.initials: W
authors.lastname: Białek
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control*; D017060:Patient Satisfaction; D011229:Preanesthetic Medication / Q000379:methods*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D016896:Treatment Outcome; D013520:Urologic Surgical Procedures
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen