title: Highly efficient construction of spirocyclic chromanone-pyrrolidines via Cu(I)/TF-BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition.
abstract: A facile synthesis of highly functional spiro-[4-chromanone-3,3'-pyrrolidine] bearing one unique spiro quarternary and three tertiary stereogenic centers is developed in excellent stereoselectivity for the first time.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
authors.forename: Tang-Lin
authors.initials: TL
authors.lastname: Liu
authors.forename: Zhao-Lin
authors.initials: ZL
authors.lastname: He
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D002839:Chromans / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D002839:Chromans; D056831:Coordination Complexes; D011759:Pyrrolidines; D013141:Spiro Compounds; C549499:TF-BiphamPhos; D003300:Copper