title: [Characteristics of audiology and clinical genetics of a Chinese family with the DFNA5 genetic hearing loss].
abstract: OBJECTIVE
  To analysis the characteristics of audiology and clinical genetics of a Chinese family with the DFNA5 genetic hearing loss in detail.
  
  
  METHODS
  A detailed family history and clinical data were collected. The Chinese pedigree is an autosomal-dominant inherited hearing loss. The data of audiological examination about genetic characteristics was analysed. The relationship between the hearing-impaired of this family and age was contrasted.
  
  
  RESULTS
  This Chinese family spanned five generations and comprised 42 members. The mode of inheritance of the families should be autosomal dominant according to the pedigree. Pure-tone audiograms showed a so-called Z shape curve. The hearing loss is sensorineural, progressive and beginning at the high frequencies. The audiograms were fairly symmetric. Whole frequencies became involved with increasing age.
  
  
  CONCLUSIONS
  The Chinese family with the DFNA5 mutation was an autosomal dominant pedigree. In this family, non-syndromic symmetric hearing impairment was severest at the high frequencies early, and gradually accumulated all frequencies of hearing. A mutation in DFNA5 leads to a type of hearing loss that closely resembles the frequently observed age-related hearing impairment. It should take into account DFNA5 mutation which the audiogram of a genetic hearing impaired has the same feature.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Institute of Otorhinolaryngology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Zhanguo
authors.initials: Z
authors.lastname: Jin
authors.forename: Jing
authors.initials: J
authors.lastname: Cheng
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.forename: Hongbo
authors.initials: H
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Lu
authors.forename: Zhengyue
authors.initials: Z
authors.lastname: Li
authors.forename: Dongyi
authors.initials: D
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D001298:Audiology; D002648:Child; D025063:Chromosome Disorders / Q000235:genetics*; D005260:Female; D034381:Hearing Loss / Q000235:genetics* / Q000503:physiopathology*; D006320:Hearing Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011960:Receptors, Estrogen / Q000235:genetics*; D055815:Young Adult; D000094524:Gasdermins
chemical_list: D011960:Receptors, Estrogen; C111432:GSDME protein, human; D000094524:Gasdermins