title: [Effect of pre-emptive pregabalin on pain intensity and morphine requirement after hysterectomy].
abstract: BACKGROUND
  Pregabalin, an antiepileptic and chronic pain medication, has been used by various authors for preoperative analgesia. We have assessed the effect of pre-emptive administration of the drug to patients scheduled for elective abdominal hysterectomy.
  
  
  METHODS
  Seventy-four ASA I and II patients were included in this prospective, double blind study. They were randomised to receive 75, 150, or 300 mg of pregabalin, or 7.5 mg of midazolam as a placebo, one hour before anaesthesia and surgery. Anaesthesia was induced with propofol and maintained with sevoflurane or desflurane. Fentanyl was used for analgesia and rocuronium for muscle relaxation. Immediately after surgery, patients received morphine intravenously in 2 mg increments until the NRS score was below 3. This was then followed by PCA.
  
  
  RESULTS
  Morphine consumption and pain scores were only significantly lower in the 300 mg pregabalin group, when compared to the placebo and other treatment groups; there were no differences between placebos and lower doses of pregabalin.
  
  
  CONCLUSIONS
  We conclude that pre-emptive administration of 300 mg pregabalin reduces postoperative pain and morphine consumption. Further studies on higher doses would appear to be justified.
authors.affiliation: II Klinika Anestezjologii i Intensywnej Terapii, Uniwersytet Medyczny w Lublinie.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Przesmycki
authors.forename: Ewa
authors.initials: E
authors.lastname: Wiater-Kozioł
authors.forename: Jan
authors.initials: J
authors.lastname: Kotarski
authors.forename: Mirosław
authors.initials: M
authors.lastname: Czuczwar
authors.forename: Robert
authors.initials: R
authors.lastname: Jaskowiak
authors.forename: Marta
authors.initials: M
authors.lastname: Zabek
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kołacz
authors.forename: Magdalena
authors.initials: M
authors.lastname: Fijałkowska
authors.forename: Marzena
authors.initials: M
authors.lastname: Kotus
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007044:Hysterectomy; D009020:Morphine / Q000627:therapeutic use*; D010147:Pain Measurement / Q000379:methods; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control*; D011229:Preanesthetic Medication; D000069583:Pregabalin; D011292:Premedication; D011446:Prospective Studies; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D009020:Morphine