title: Three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, alkyne, with sulfonyl azide via a multicatalytic process: a novel and concise approach to 2-amino-H-pyrazolo[5,1-a]isoquinolines.
abstract: A novel and efficient route for the synthesis of 2-amino-H-pyrazolo[5,1-a]isoquinolines via a three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, alkyne, and sulfonyl azide is described. This transformation, co-catalyzed by silver triflate and copper(I) bromide under mild conditions, proceeds efficiently to generate the 2-amino-H-pyrazolo[5,1-a]isoquinolines in good to excellent yields.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors.forename: Shaoyu
authors.initials: S
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000586:Amination; D001386:Azides / Q000737:chemistry*; D001597:Benzylidene Compounds / Q000737:chemistry*; D002384:Catalysis; D006834:Hydrazines / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis*; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D001597:Benzylidene Compounds; D006834:Hydrazines; D007546:Isoquinolines; D011720:Pyrazoles; D013450:Sulfones; C031280:pyrazole