title: Lipid profile changes and importance of low serum α-lipoprotein fraction (high-density lipoprotein) in cases with acute pancreatitis.
abstract: OBJECTIVE
  Acute pancreatitis (AP) is a common systemic inflammatory disorder of the pancreas. The data related to the lipid changes in patients with AP were insufficient. In this study, we aimed to investigate the relation between high-density lipoprotein (HDL) and the other lipid parameters and the severity of the disease in AP cases.
  
  
  METHODS
  Seventy-five cases admitted to the Gastroenterohepatology Clinic with diagnosis of AP were included in the study. Ranson scores and Glasgow scores were used for prognosis. Lipid parameters were evaluated for the first 24 hours and after clinic and laboratory remission.
  
  
  RESULTS
  The causes of the disease among patients included in the study were as follows: 44 biliary origin (58.7%), 14 alcohol dependent (18.7%), 10 idiopathic (13.3%), 6 hyperlipidemic (8%), and 1 endoscopic retrograde cholangiopancreatography dependent (1.3%). Triglyceride (TG) levels of the patients included in the study measured in the first 2 days were significantly higher than TG levels measured after clinic and laboratory remission (P = 0.013). High-density lipoprotein was significantly lower in alcoholic and hypertriglyceridemic AP cases. There was a statistical correlation between HDL and Ranson (P = 0.023).
  
  
  CONCLUSIONS
  The low levels of HDL in AP cases during acute attack are associated with severity of the disease.
authors.affiliation: Gastroenterohepatology Clinic, Şişli Etfal Training and Research Hospital, Şişli, Istanbul. msbugdaci@gmail.com
authors.forename: Mehmet Sait
authors.initials: MS
authors.lastname: Bugdaci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sokmen
authors.forename: Sayid Shafi
authors.initials: SS
authors.lastname: Zuhur
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Altuntas
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000681:Amylases / Q000097:blood; D005260:Female; D006801:Humans; D007902:Length of Stay; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000175:diagnosis*; D018570:Risk Assessment; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008055:Lipids; D008075:Lipoproteins, HDL; D014280:Triglycerides; D000681:Amylases