title: Design, rationale, and initiation of the Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial: a report from the Cardiothoracic Surgical Trials Network.
abstract: OBJECTIVE
  Patients with coronary artery disease complicated by moderate ischemic mitral regurgitation have demonstrably poorer outcome than do patients with coronary artery disease but without mitral regurgitation. The optimal treatment of this condition has become increasingly controversial, and a randomized trial evaluating current practices is warranted.
  
  
  METHODS
  We describe the design and initial execution of the Cardiothoracic Surgical Trials Network Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial.
  
  
  RESULTS
  This is an ongoing prospective, multicenter, randomized, controlled clinical trial designed to test the safety and efficacy of mitral repair in addition to coronary artery bypass grafting in the treatment of moderate ischemic mitral regurgitation.
  
  
  CONCLUSIONS
  The results of the Cardiothoracic Surgical Trials Network Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial will provide long-awaited information on controversial therapies for this morbid disease process.
authors.affiliation: Division of Cardiovascular and Thoracic Surgery, Duke University, Durham, NC, USA.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Smith
authors.forename: Robert E
authors.initials: RE
authors.lastname: Michler
authors.forename: Y Joseph
authors.initials: YJ
authors.lastname: Woo
authors.forename: John H
authors.initials: JH
authors.lastname: Alexander
authors.forename: John D
authors.initials: JD
authors.lastname: Puskas
authors.forename: Michael K
authors.initials: MK
authors.lastname: Parides
authors.forename: Rebecca T
authors.initials: RT
authors.lastname: Hahn
authors.forename: Judson B
authors.initials: JB
authors.lastname: Williams
authors.forename: John M
authors.initials: JM
authors.lastname: Dent
authors.forename: T Bruce
authors.initials: TB
authors.lastname: Ferguson
authors.forename: Ellen
authors.initials: E
authors.lastname: Moquete
authors.forename: Eric A
authors.initials: EA
authors.lastname: Rose
authors.forename: Pierre
authors.initials: P
authors.lastname: Pagé
authors.forename: Neal O
authors.initials: NO
authors.lastname: Jeffries
authors.forename: Patrick T
authors.initials: PT
authors.lastname: O'Gara
authors.forename: Deborah D
authors.initials: DD
authors.lastname: Ascheim
mesh_terms: D003324:Coronary Artery Disease / Q000150:complications*; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000601:surgery*; D011446:Prospective Studies; D012720:Severity of Illness Index