title: Bisphenol A exposure reduces the estradiol response to gonadotropin stimulation during in vitro fertilization.
abstract: OBJECTIVE
  To investigate associations between serum bisphenol A (BPA) concentrations and follicular response to exogenous ovary stimulation.
  
  
  METHODS
  Fasting serum was prospectively collected on the day of oocyte retrieval and assessed for unconjugated BPA using high-performance liquid chromatography with Coularray detection. Multivariable linear regression and negative binomial regression were used to assess associations between concentrations of BPA and outcome measures. Models were adjusted for race/ethnicity, antral follicle count at baseline, and cigarette smoking.
  
  
  METHODS
  A reproductive health center.
  
  
  METHODS
  Forty-four women undergoing IVF.
  
  
  METHODS
  None.
  
  
  METHODS
  Peak E(2) level and the number of oocytes retrieved during IVF.
  
  
  RESULTS
  The median unconjugated serum BPA concentration is 2.53 ng/mL (range = 0.3-67.36 ng/mL). Bisphenol A is inversely associated with E(2) (β = -0.16; 95% confidence interval = -0.32, 0.01), as well as with E(2) normalized to the number of mature-sized follicles at the hCG trigger (β = -0.14; 95% confidence interval = -0.24, -0.03). No association is observed for BPA and the number of oocytes retrieved (adjusted risk ratio = 0.95; 95% confidence interval = 0.82, 1.10).
  
  
  CONCLUSIONS
  Bisphenol A is associated with a reduced E(2) response during IVF. Although limited by the preliminary nature of this study, these results merit confirmation in a future comprehensive investigation.
authors.affiliation: Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY 12144, USA. mbloom@albany.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Bloom
authors.forename: Dongsul
authors.initials: D
authors.lastname: Kim
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Vom Saal
authors.forename: Julia A
authors.initials: JA
authors.lastname: Taylor
authors.forename: Gloria
authors.initials: G
authors.lastname: Cheng
authors.forename: Julie D
authors.initials: JD
authors.lastname: Lamb
authors.forename: Victor Y
authors.initials: VY
authors.lastname: Fujimoto
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds; D004958:Estradiol / Q000097:blood*; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods* / Q000706:statistics & numerical data; D006062:Gonadotropins / Q000819:agonists*; D006801:Humans; D007246:Infertility / Q000453:epidemiology / Q000628:therapy; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D054315:Oocyte Retrieval / Q000379:methods / Q000706:statistics & numerical data; D006080:Ovarian Follicle / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010062:Ovulation Induction / Q000379:methods* / Q000706:statistics & numerical data; D010636:Phenols / Q000008:administration & dosage*; D010865:Pilot Projects; D011446:Prospective Studies; D012307:Risk Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004958:Estradiol; D004968:Estrogens, Non-Steroidal; D006062:Gonadotropins; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds