title: Deaths associated with human adenovirus-14p1 infections, Europe, 2009-2010.
abstract: Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.
authors.affiliation: National Virus Reference Laboratory-University College Dublin, Dublin, Ireland. michael.carr@ucd.ie
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Carr
authors.forename: Adriana E
authors.initials: AE
authors.lastname: Kajon
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lu
authors.forename: Linda
authors.initials: L
authors.lastname: Dunford
authors.forename: Paul
authors.initials: P
authors.lastname: O'Reilly
authors.forename: Paul
authors.initials: P
authors.lastname: Holder
authors.forename: Cillian F
authors.initials: CF
authors.lastname: De Gascun
authors.forename: Suzie
authors.initials: S
authors.lastname: Coughlan
authors.forename: Jeff
authors.initials: J
authors.lastname: Connell
authors.forename: Dean D
authors.initials: DD
authors.lastname: Erdman
authors.forename: William W
authors.initials: WW
authors.lastname: Hall
mesh_terms: D017500:Adenovirus E1A Proteins / Q000235:genetics; D000258:Adenovirus Infections, Human / Q000401:mortality* / Q000821:virology; D000260:Adenoviruses, Human / Q000145:classification* / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D036022:Capsid Proteins / Q000235:genetics; D045744:Cell Line, Tumor; D002675:Child, Preschool; D021821:Communicable Diseases, Emerging / Q000401:mortality* / Q000821:virology; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012141:Respiratory Tract Infections / Q000401:mortality* / Q000821:virology; D017422:Sequence Analysis, DNA; D012703:Serotyping; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology; D014776:Virus Cultivation
chemical_list: D017500:Adenovirus E1A Proteins; D000914:Antibodies, Viral; D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus