title: Toxicokinetics of pyrethroid metabolites in male and female rats.
abstract: The toxicokinetic characteristics of 3-phenoxybenzyl alcohol (3PBAlc) and 3-phenoxybenzaldehyde (3PBAld; metabolites of pyrethroid [PYR] after 25mg/kg, single intravenous administration), were investigated in male and female rats. The systemic clearance (Cl) of 3PBAlc in females (0.403±0.040l/h/kg) was significantly larger than that of males (0.227±0.036l/h/kg). The plasma concentration-time curve of 3PBAld decreased gradually and then increased again 1 and 2h after injection, suggesting the effect of enterohepatic circulation. The present study characterized the elimination and distribution of PYR metabolites and suggests that gender-related difference exists in the toxicokinetics of 3PBAlc and 3PBAld in rats.
authors.affiliation: Department of Medical Technology, Nagoya University School of Health Sciences, 1-1-20 Daikominami, Higashi-ku, Nagoya 461-8673, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Ueyama
authors.forename: Naoko
authors.initials: N
authors.lastname: Hirosawa
authors.forename: Aiko
authors.initials: A
authors.lastname: Mochizuki
authors.forename: Akiko
authors.initials: A
authors.lastname: Kimata
authors.forename: Michihiro
authors.initials: M
authors.lastname: Kamijima
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kondo
authors.forename: Kenji
authors.initials: K
authors.lastname: Takagi
authors.forename: Shinya
authors.initials: S
authors.lastname: Wakusawa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hasegawa