title: Intralesional interferon-α for the treatment of bilateral conjunctival mucosa-associated lymphoid tissue lymphoma.
abstract: We describe a case of bilateral conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma in a 14-year-old female treated with intralesional interferon-α. Interferon-α-2b was injected three times a week for 6 weeks, then once weekly for 12 weeks. Marked tumor reduction was observed by week 5 of treatment, with complete resolution by week 8. There was no sign of recurrence through 27 months of follow-up. Intralesional interferon-α was an effective treatment for this unusual case of conjunctival MALT lymphoma in a very young female. It presents an attractive alternative to traditional treatment modalities in this patient population.
authors.affiliation: Department of Ophthalmology, Saint Louis University, St. Louis, Missouri, USA.
authors.forename: John
authors.initials: J
authors.lastname: Holds
authors.forename: Adam
authors.initials: A
authors.lastname: Buchanan
authors.forename: Robin
authors.initials: R
authors.lastname: Hanson
mesh_terms: D000293:Adolescent; D003230:Conjunctival Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D016898:Interferon-alpha / Q000008:administration & dosage*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy* / Q000473:pathology*; D012074:Remission Induction
chemical_list: D007155:Immunologic Factors; D016898:Interferon-alpha