title: Intraoperative sentinel lymph node mapping in patients with colon cancer: study of 38 cases.
abstract: OBJECTIVE
  Sentinel lymph node mapping has become a cornerstone of oncologic surgery because it is a proven method for identifying nodal disease in melanoma and breast cancer. In addition, it can ameliorate the surgical morbidity secondary to lymphadenectomy. However, experience with sentinel lymph node mapping for carcinoma of the colon and other visceral malignancies is limited. The purpose of this study was to evaluate the feasibility and reliability of in vivo sentinel lymph node mapping in patients with colon cancer.
  
  
  METHODS
  In the period March 2004 through June 2009, 38 patients underwent curative surgery for colon cancer. Thirty-eight patients with intraperitoneal colon tumors undergoing resection were studied prospectively. Sentinel lymph nodes were identified as the first blue-stained node(s) after in vivo peritumoral injection of Isosulfan blue dye.
  
  
  RESULTS
  Detection of sentinel lymph nodes was successful in 36 out of 38 colon cancer patients. In 94.7% of the patients with colon cancer, at least one sentinel lymph node was found. No patients had a false negative sentinel node. The sensitivity was 100%, with a negative predictive value of 100%. Aberrant lymphatic drainage was not identified in any patient.
  
  
  CONCLUSIONS
  The technique of in vivo sentinel lymph node mapping is technically feasible with high sensitivity, high negative predictive value, and high accuracy. Although sentinel lymph node mapping did not alter the surgical management of colon cancer, it does make possible a more focused and cost-effective pathologic evaluation of nodal disease.
authors.affiliation: Department of General Surgery and Burn Unit, Erzurum Region Education and Research Hospital, Erzurum, Turkey. yavuzalbayrakdr@gmail.com
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Albayrak
authors.forename: Durkaya
authors.initials: D
authors.lastname: Oren
authors.forename: Cemal
authors.initials: C
authors.lastname: Gündoğdu
authors.forename: Ali
authors.initials: A
authors.lastname: Kurt
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D004396:Coloring Agents; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012394:Rosaniline Dyes; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy; D015996:Survival Rate
chemical_list: D004396:Coloring Agents; D012394:Rosaniline Dyes; C025484:iso-sulfan blue