title: Role of 5-lipoxygenase pathway in the pathophysiology of the aortic stenosis.
abstract: Understanding the exact pathophysiological mechanism of degenerative aortic stenosis is important in order to develop new treatment modalities and prevent progression of the disease. Recently, most of the inflammatory markers in association with aortic stenosis have been described. The authors of the paper under evaluation investigate the effects of the 5-lipoxygenase pathway on aortic valve stenosis and correlation with severity of stenosis. In this article, we suggest that the 5-lipoxygenase pathway is one of the possible factors in the development of aortic stenosis.
authors.affiliation: Sakarya University, Medical Faculty, Department of Cardiology, Sakarya, Turkey. rakdemir@yahoo.com
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akdemir
authors.forename: M Bulent
authors.initials: MB
authors.lastname: Vatan