title: Human parvovirus 4 as potential cause of encephalitis in children, India.
abstract: To investigate whether uncharacterized infectious agents were associated with neurologic disease, we analyzed cerebrospinal fluid specimens from 12 children with acute central nervous system infection. A high-throughput pyrosequencing screen detected human parvovirus 4 DNA in cerebrospinal fluid of 2 children with encephalitis of unknown etiology.
authors.affiliation: University of Liverpool Institute of Infection and Global Health, Liverpool, UK.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Benjamin
authors.forename: Penny
authors.initials: P
authors.lastname: Lewthwaite
authors.forename: Ravi
authors.initials: R
authors.lastname: Vasanthapuram
authors.forename: Guoyan
authors.initials: G
authors.lastname: Zhao
authors.forename: Colin
authors.initials: C
authors.lastname: Sharp
authors.forename: Peter
authors.initials: P
authors.lastname: Simmonds
authors.forename: David
authors.initials: D
authors.lastname: Wang
authors.forename: Tom
authors.initials: T
authors.lastname: Solomon
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000235:genetics; D018792:Encephalitis, Viral / Q000453:epidemiology / Q000821:virology*; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007194:India / Q000453:epidemiology; D008969:Molecular Sequence Data; D010322:Parvoviridae Infections / Q000453:epidemiology / Q000821:virology*; D017992:Parvovirus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007075:Immunoglobulin M