title: Adherence to and appropriateness of anti-osteoporotic treatments in patients aged 50 and over in the Valencia Region (Spain). The ESOSVAL-AD study.
abstract: BACKGROUND
  A study to evaluate the adherence to and appropriateness of anti-osteoporotic treatments in a cohort of men and women aged 50 and over participating in the ESOSVAL-R study.
  
  
  METHODS
  
  
  
  METHODS
  An observational, longitudinal, prospective cohort study;
  
  
  METHODS
  Men and women aged 50 and over living in the Valencia Region (Spain) who initiated treatment between June 15, 2009, and June 15, 2011, in primary healthcare centers with electronic medical records;
  
  
  METHODS
  The main data source will be electronic medical records. Measurement of results: Degree of compliance with and persistence of anti-osteoporotic treatments, and the proportion of patients with appropriate anti-osteoporotic treatment in accordance with the most relevant and high impact recommendations with clearly defined treatment algorithms in Spain (the Spanish National Health System guide (2010), the General Practitioners' Society (2007) and the General Directorate for Pharmacy and Medical Products of Madrid (2007)), and with the National Osteoporosis Foundation (NOF, 2010), and the International Osteoporosis Foundation guidelines (IOF, 2008);
  
  
  METHODS
  1.) Descriptive analysis of patients undergoing treatment and the treatments prescribed; 2.) Descriptive analysis of compliance with and persistence of anti-osteoporotic treatments; 3.) ANALYSIS of factors associated with compliance with and persistence of treatments by Cox proportional hazard regression models, 4.) Descriptive analysis of appropriateness of treatment; 5.) ANALYSIS of factors associated with the appropriateness of treatment by multilevel models (4 levels: patient, doctor, Basic Healthcare Zone/Primary Healthcare Center, and Health Area variables).
  
  
  CONCLUSIONS
  ESOSVAL-AD will provide information regarding adherence to osteoporosis treatments and the factors associated with a higher or lower adherence (including the appropriateness of the treatment) in the Spanish context. A better understanding of this phenomenon and the interventions needed to address it would contribute to the increased effectiveness of therapeutic measures, a reduction in morbidity and mortality, and a corresponding reduction in healthcare costs.
authors.affiliation: Centro Superior de Investigación en Salud Pública (Center for Public Health Research),Valencia, Spain. sanfelix_gab@gva.es
authors.forename: Gabriel
authors.initials: G
authors.lastname: Sanfélix-Gimeno
authors.forename: José
authors.initials: J
authors.lastname: Sanfélix-Genovés
authors.forename: Salvador
authors.initials: S
authors.lastname: Peiró
authors.forename: Isabel
authors.initials: I
authors.lastname: Hurtado
authors.forename: José Luis
authors.initials: JL
authors.lastname: Trillo
authors.forename: Ruth
authors.initials: R
authors.lastname: Usó
authors.forename: Vicente Giner
authors.initials: VG
authors.lastname: Ruiz
authors.forename: Manuel Pascual
authors.initials: MP
authors.lastname: de la Torre
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Ferreros
mesh_terms: D000465:Algorithms; D050071:Bone Density Conservation Agents / Q000191:economics / Q000627:therapeutic use*; D002985:Clinical Protocols / Q000592:standards; D002986:Clinical Trials as Topic / Q000379:methods; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy* / Q000191:economics / Q000453:epidemiology; D010349:Patient Compliance; D018579:Patient Selection; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents