title: Adrenomedullin: possible predictor of insulin resistance in women with polycystic ovary syndrome.
abstract: The aim of the study was to investigate adrenomedullin (ADM) levels and its relation with insulin resistance in women with polycystic ovary syndrome (PCOS). Twenty-nine women with PCOS and 29 age- and body mass index (BMI)- matched control subjects were included in the study. PCOS was defined according to criteria by the Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)-sponsored PCOS consensus workshop group. A full clinical and biochemical examination including basal hormones and metabolic profile was performed. Insulin resistance was calculated by using the homeostasis model assessment of insulin resistance index (HOMA-IR). Plasma ADM levels were measured by high performance liquid chromatographic (HPLC) method. Plasma ADM, fasting insulin levels and HOMA-IR were significantly higher in patients with PCOS than the control group. ADM levels were positively correlated with insulin levels and HOMA-IR index. The best cut-off value of ADM levels to identify the presence of insulin resistance (HOMA-IR≥2.7) was 30.44 ng/ml. Calculated odds ratio of insulin resistance by using logistic regression analysis, as predicted by ADM, was 0.15 (95% confidence interval, 0.037-0.628; p=0.009). In multiple regression analysis, ADM level was an independent predictor of HOMA-IR index. Our finding indicated that ADM levels increased in women with PCOS in accordance with HOMA-IR. ADM could be a significant independent determinant of insulin resistance in women with PCOS.
authors.affiliation: Endocrinology and Metabolism, Inönü University, Malatya, Turkey. isahin@inonu.edu.tr
authors.forename: I
authors.initials: I
authors.lastname: Sahin
authors.forename: O
authors.initials: O
authors.lastname: Celik
authors.forename: N
authors.initials: N
authors.lastname: Celik
authors.forename: L
authors.initials: L
authors.lastname: Keskin
authors.forename: A
authors.initials: A
authors.lastname: Dogru
authors.forename: I
authors.initials: I
authors.lastname: Dogru
authors.forename: M
authors.initials: M
authors.lastname: Yürekli
authors.forename: S
authors.initials: S
authors.lastname: Yologlu
mesh_terms: D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids; D053607:Adrenomedullin