title: Association of adiponectin with carotid arteriosclerosis in predialysis chronic kidney disease.
abstract: OBJECTIVE
  Adiponectin is an adipocyte-derived protein with antiatherogenic properties. Chronic kidney disease (CKD) is one of the risk factors for cardiovascular disease. We investigated the potential association between adiponectin and carotid arteriosclerosis in patients with predialysis CKD.
  
  
  METHODS
  We enrolled 95 CKD patients without dialysis and 81 non-CKD patients. Intima-media thickness (IMT) and plaque score (PS) in the common carotid artery were measured using an ultrasound system. Carotid arteriosclerosis was defined as IMT >1.2 mm and/or PS >5.0 mm.
  
  
  RESULTS
  The prevalence of CKD was independently associated with carotid arteriosclerosis after adjustment for other risk factors. Higher adiponectin levels were observed in CKD patients compared with non-CKD patients. Adiponectin levels were not independently correlated with the presence of carotid arteriosclerosis in all subjects. To evaluate the association between adiponectin and carotid arteriosclerosis among a CKD population, we divided the CKD patients into 2 groups according to a cutoff level of adiponectin determined by ROC analysis. The prevalence of carotid arteriosclerosis was significantly higher in the low-adiponectin group than in the high-adiponectin group among CKD patients. After adjusting for other risk factors, low levels of adiponectin were independently correlated with carotid arteriosclerosis in CKD patients.
  
  
  CONCLUSIONS
  Our data document that adiponectin is associated with increased risk of carotid atherosclerosis in a predialysis CKD population.
authors.affiliation: Department of Nephrology, Nagoya University Graduate School of Medicine, Japan.
authors.forename: Mutsuharu
authors.initials: M
authors.lastname: Hayashi
authors.forename: Rei
authors.initials: R
authors.lastname: Shibata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishii
authors.forename: Toru
authors.initials: T
authors.lastname: Aoyama
authors.forename: Hirotake
authors.initials: H
authors.lastname: Kasuga
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yamada
authors.forename: Koji
authors.initials: K
authors.lastname: Ohashi
authors.forename: Syoichi
authors.initials: S
authors.lastname: Maruyama
authors.forename: Seiichi
authors.initials: S
authors.lastname: Matsuo
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ouchi
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
authors.forename: Takanobu
authors.initials: T
authors.lastname: Toriyama
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000502:physiology*; D000368:Aged; D002340:Carotid Artery Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D059168:Carotid Intima-Media Thickness; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: D052242:Adiponectin