title: Non-genomic actions of aldosterone: from receptors and signals to membrane targets.
abstract: In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid 'non-genomic' activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation.
authors.affiliation: Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
authors.forename: Ruth
authors.initials: R
authors.lastname: Dooley
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Harvey
authors.forename: Warren
authors.initials: W
authors.lastname: Thomas
mesh_terms: D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D003593:Cytoplasm / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism / Q000502:physiology; D020239:Receptor Cross-Talk / Q000502:physiology; D018161:Receptors, Mineralocorticoid / Q000378:metabolism / Q000502:physiology*; D015290:Second Messenger Systems / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D018161:Receptors, Mineralocorticoid; D000450:Aldosterone; D011494:Protein Kinases