title: Cytologic, immunocytologic, histopathologic and immunohistologic diagnosis of the poorly differentiated sertoli-leydig cell tumor.
abstract: BACKGROUND
  Sertoli-Leydig cell tumors (SLCTs), also known as arrhenoblastomas, are tumors of the sex cord-stromal group of ovary and testis cancers. They comprise <1% of all ovarian tumors. They are divided into 6 categories based on the degree of differentiation and the presence of heterologous elements. However, <15% of these tumors are poorly differentiated.
  
  
  METHODS
  A 23-year-old unmarried female presented with an 8-month history of irregular menstrual cycle and abdominal pain. There were no clinical features suggesting virilization. The left salpingo-oophorectomy specimen revealed an oval ovarian mass of 11 × 7 × 4 cm in dimension. Grossly, the cut surface of the mass was yellowish white in color and solid in consistency and touch preparation was made. By applying cytology and immunocytochemistry techniques, a preliminary diagnosis suggestive of poorly differentiated SLCT was made. The tumor was confirmed as a poorly differentiated SLCT.
  
  
  CONCLUSIONS
  Cytology and immunocytochemistry by WT-1, melan A, vimentin and calretinin are helpful in the diagnosis of poorly differentiated SLCTs.
authors.affiliation: Department of Hematopathology, Dr. Daneshbod Pathology Laboratory, Shiraz, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Soleimanpour
authors.forename: S
authors.initials: S
authors.lastname: Shirian
authors.forename: A
authors.initials: A
authors.lastname: Oryan
authors.forename: K
authors.initials: K
authors.lastname: Daneshbod
authors.forename: N
authors.initials: N
authors.lastname: Bagheri
authors.forename: Y
authors.initials: Y
authors.lastname: Daneshbod
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D064032:Calbindin 2; D002454:Cell Differentiation; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D058965:MART-1 Antigen / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D011379:Prognosis; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D018310:Sertoli-Leydig Cell Tumor / Q000175:diagnosis*; D014746:Vimentin / Q000378:metabolism; D025721:WT1 Proteins / Q000378:metabolism; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C576764:CALB2 protein, human; D064032:Calbindin 2; D058965:MART-1 Antigen; D064030:S100 Calcium Binding Protein G; D014746:Vimentin; D025721:WT1 Proteins