title: Cinchona alkaloids are also produced by an endophytic filamentous fungus living in cinchona plant.
abstract: We report that the endophytic filamentous fungus Diaporthe sp., isolated from Cinchona ledgeriana and cultivated in a synthetic liquid medium, produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine). This shows that Cinchona alkaloids are produced not only in Cinchona plant cells, but also in endophytic microbe cells.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Maehara
authors.forename: Partomuan
authors.initials: P
authors.lastname: Simanjuntak
authors.forename: Chinami
authors.initials: C
authors.lastname: Kitamura
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ohashi
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002929:Cinchona / Q000382:microbiology*; D002930:Cinchona Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D005658:Fungi / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002930:Cinchona Alkaloids