title: A facile synthesis of highly functionalized 4-arylcoumarins via Kostanecki reactions mediated by DBU.
abstract: An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity.
authors.affiliation: Green Chemistry Division, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong, Taejon 305-600, Korea.
authors.forename: In-Taek
authors.initials: IT
authors.lastname: Hwang
authors.forename: Sun-Ah
authors.initials: SA
authors.lastname: Lee
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Hwang
authors.forename: Kee-In
authors.initials: KI
authors.lastname: Lee
mesh_terms: D000089:Acetic Anhydrides / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry; D001577:Benzophenones / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis*; D002625:Chemistry, Organic / Q000379:methods*; D003374:Coumarins / Q000138:chemical synthesis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D013696:Temperature
chemical_list: D000089:Acetic Anhydrides; D001391:Azo Compounds; D001577:Benzophenones; D001688:Biological Products; D003374:Coumarins; D005456:Fluorescent Dyes; C031800:acetic anhydride; C562127:ortho-hydroxybenzophenone