title: RNA toxins: mediators of stress adaptation and pathogen defense.
abstract: RNA toxins are a group of enzymes primarily synthesized by bacteria, fungi, and plants that either cleave or depurinate RNA molecules. These proteins may be divided according to their RNA substrates: ribotoxins are nucleases that cleave ribosomal RNA (rRNA), ribosome inactivating proteins are glycosidases that remove a base from rRNA, messenger RNA (mRNA) interferases are nucleases that cleave mRNAs, and anticodon nucleases cleave transfer RNAs (tRNAs). These modifications to the RNAs may substantially alter gene expression and translation rates. Given that some of these enzymes cause cell death, it has been suggested that they function mainly in defense, either to kill competing cells or to elicit suicide and thereby limit pathogen spread from infected cells. Although good correlations have been drawn between their enzymatic functions and toxicity, recent work has shown that some RNA toxins cause apoptosis in the absence of damage to RNA and that defense against pathogens can be achieved without host cell death. Moreover, a decrease in cellular translation rate, insufficient to cause cell death, allows some organisms to adapt to stress and environmental change. Although ascribing effects observed in vitro to the roles of these toxins in nature has been challenging, recent results have expanded our understanding of their modes of action, and emphasized the importance of these toxins in development, adaptation to stress and defense against pathogens.
authors.affiliation: Department of Biology, York University, Toronto, Ontario, Canada.
authors.forename: Alice
authors.initials: A
authors.lastname: Zhabokritsky
authors.forename: Meherzad
authors.initials: M
authors.lastname: Kutky
authors.forename: Lydia A
authors.initials: LA
authors.lastname: Burns
authors.forename: Rajita A
authors.initials: RA
authors.lastname: Karran
authors.forename: Katalin A
authors.initials: KA
authors.lastname: Hudak
mesh_terms: D000220:Adaptation, Biological; D000998:Antiviral Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D005658:Fungi / Q000378:metabolism; D054884:Host-Pathogen Interactions; D008954:Models, Biological; D014176:Protein Biosynthesis / Q000187:drug effects; D012313:RNA / Q000187:drug effects* / Q000378:metabolism*; D059367:RNA Cleavage; D012260:Ribonucleases / Q000378:metabolism / Q000633:toxicity; D054788:Ribosome Inactivating Proteins / Q000378:metabolism / Q000633:toxicity; D013312:Stress, Physiological; D014118:Toxins, Biological / Q000378:metabolism / Q000633:toxicity
chemical_list: D000998:Antiviral Agents; D014118:Toxins, Biological; D012313:RNA; D012260:Ribonucleases; C049345:anticodon nuclease; D054788:Ribosome Inactivating Proteins