title: Preparation of ultrafine fast-dissolving feruloyl-oleyl-glycerol-loaded polyvinylpyrrolidone fiber mats via electrospinning.
abstract: Fast-dissolving drug delivery membranes for poorly water-soluble drugs were prepared by electrospinning using feruloyl-oleyl-glycerol (FOG) as a model drug and polyvinylpyrrolidone (PVP) K90 as a polymer matrix in a mixed solvent of chloroform/ethanol (4:1, v/v). Results from Fourier-transform infrared spectroscopy (FT-IR) illustrated good compatibility between FOG and PVP as well as a good distribution of FOG within the fibers. The morphology and diameter of the fibers were influenced by the concentration of PVP and the applied voltage. When the PVP concentration was 5% (w/v) and the applied voltage was 14 kV, uniform and smooth fibers were obtained, with diameter 700-800 nm. Wetting time assays confirmed fast-dissolving properties with the average dissolution time for FOG-loaded PVP fiber membranes being 2.0±1.5 s. These results demonstrate the potential of electrospinning solid dispersions to improve the dissolution profile of poorly water-soluble drugs.
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Quan
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Christopher
authors.initials: C
authors.lastname: Branford-White
authors.forename: Gareth R
authors.initials: GR
authors.lastname: Williams
authors.forename: Deng-Guang
authors.initials: DG
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Nie
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Zhu
mesh_terms: D002725:Chloroform / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D011205:Povidone / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D004337:Drug Carriers; D000431:Ethanol; D002725:Chloroform; D011205:Povidone