title: [First experience with intrasurgical brachytherapy in the combined treatment for locally advanced laryngeal cancer].
abstract: Results of combined radiosurgical treatment with larynx preservation, and pre- and postoperative distant external irradiation, were evaluated. Forty-eight patients with locally advanced laryngeal cancer received single-step individually-tailored tissue application, followed by high-dose brachytherapy. Discriminative function of the larynx was restored in all patients within 2 days involving swallowing disturbances in 8%. Breathing function was restored in 98% within 2 days to 6 months after completion of treatment. Three-year relapse-free survival was 95.8%.
authors.forename: I L
authors.initials: IL
authors.lastname: Vasil'chenko
authors.forename: V M
authors.initials: VM
authors.lastname: Vinogradov
authors.forename: D A
authors.initials: DA
authors.lastname: Pastushenko
authors.forename: N N
authors.initials: NN
authors.lastname: Samsonova
authors.forename: A L
authors.initials: AL
authors.lastname: Iudin
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy* / Q000601:surgery*; D003679:Deglutition; D018572:Disease-Free Survival; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy* / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D007830:Larynx / Q000473:pathology / Q000503:physiopathology* / Q000528:radiation effects / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D011881:Radiotherapy, Computer-Assisted; D012119:Respiration; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007496:Iridium Radioisotopes