title: Indole alkaloids from Aspidosperma rigidum and A. schultesii and their antiparasitic effects.
abstract: Five oxindole alkaloids, three plumerane-type alkaloids, subtype haplophitine, and one aspidospermatane-type alkaloid, subtype tubotaiwine, were isolated from the medicinal plants Aspidosperma rigidum and A. schultesii. One compound was identified as the transoid conformer of 18-oxo-O-methylaspidoalbine which was not previously described. The antiparasitic activity of all compounds against Trypanosoma cruzi and Leishmania infantum and their non-specific cytotoxicity against mammalian cells were also determined.
authors.affiliation: Instituto de Productos Naturales y Agrobiología (IPNA), CSIC, Avda. Astrofísico F, Sánchez 3, P. O. Box 195, 38206 - La Laguna, Tenerife, Canary Islands, Spain. mreina@ipna.csic.es
authors.forename: Matías
authors.initials: M
authors.lastname: Reina
authors.forename: Wilfredo
authors.initials: W
authors.lastname: Ruiz-Mesia
authors.forename: Lastenia
authors.initials: L
authors.lastname: Ruiz-Mesia
authors.forename: Rafael
authors.initials: R
authors.lastname: Martínez-Díaz
authors.forename: Azucena
authors.initials: A
authors.lastname: González-Coloma
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology*; D030009:Aspidosperma / Q000737:chemistry*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D026121:Indole Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013045:Species Specificity; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000977:Antiparasitic Agents; D026121:Indole Alkaloids