title: Lack of Association Between COMT Polymorphisms and Apathy in Alzheimer's Disease.
abstract: We tested the hypothesis that single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) are associated with apathy in individuals with Alzheimer's disease (AD). We analyzed a cohort of 105 Caucasian individuals with AD (age = 79.3 ± 7.03 years; MMSE = 20.2 ± 4.4) according to the presence of apathy, as defined either by the Neuropsychiatric Inventory or the Apathy Inventory. Polymorphisms in seventeen SNPs in COMT were examined. A replication cohort consisting of 176 Caucasian AD subjects in the ADNI database was also analyzed. None of the candidate gene SNPs were significantly associated with the presence of apathy in either cohort. We did not find any SNPs in COMT that were consistently associated with apathy in individuals with AD.
authors.affiliation: Centre Mémoire de Ressources de Recherche - EA CoBTeK, CHU University of Nice Sophia Antipolis, Nice, France. david.r@chu-nice.fr
authors.forename: Renaud
authors.initials: R
authors.lastname: David
authors.forename: Leah
authors.initials: L
authors.lastname: Friedman
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mulin
authors.forename: Art
authors.initials: A
authors.lastname: Noda
authors.forename: Franck
authors.initials: F
authors.lastname: Le Duff
authors.forename: Quinn
authors.initials: Q
authors.lastname: Kennedy
authors.forename: Rene
authors.initials: R
authors.lastname: Garcia
authors.forename: Philippe H
authors.initials: PH
authors.lastname: Robert
authors.forename: Jerome A
authors.initials: JA
authors.lastname: Yesavage
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Zeitzer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D057565:Apathy / Q000502:physiology*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D016009:Chi-Square Distribution; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales
chemical_list: D002394:Catechol O-Methyltransferase