title: Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.
abstract: Single-nucleotide and diplotype associations with 17-item Hamilton Depression Rating Scale (HAMD(17)) total score changes were examined, based on catechol-O-methyltransferase (COMT) rs165599 status in duloxetine-treated, self-identified white patients with major depressive disorder. COMT rs165737 and a diplotype containing COMT rs165599 and COMT rs165737 were associated with HAMD(17) total score changes.
authors.affiliation: Neuroscience Department, Eli Lilly and Company, LLC, Indianapolis, IN, USA. houston_jonh_p@lilly.com
authors.forename: John P
authors.initials: JP
authors.lastname: Houston
authors.forename: Jared
authors.initials: J
authors.lastname: Kohler
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Ostbye
authors.forename: Alexandra
authors.initials: A
authors.lastname: Heinloth
authors.forename: Roy H
authors.initials: RH
authors.lastname: Perlis
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D000068736:Duloxetine Hydrochloride; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride; D002394:Catechol O-Methyltransferase