title: Comparative evaluation of platelet-rich plasma and guided tissue regeneration membrane in the healing of apicomarginal defects: a clinical study.
abstract: BACKGROUND
  The aim of the study was to compare the healing responses of platelet-rich plasma (PRP), PRP + a collagen sponge, and a collagen membrane used as guided tissue regeneration (GTR) materials for the treatment of apicomarginal defects.
  
  
  METHODS
  Thirty patients with suppurative chronic apical periodontitis and apicomarginal communication were selected and allocated randomly into three groups according to the barrier technique to be used during periradicular surgery: the collagen membrane group, the PRP group, and the PRP + collagen sponge group. Clinical and radiographic measurements were determined at baseline and every 3 months after surgery up to 1 year. Cases were defined as healed when no clinical signs or symptoms were present, and radiographs showed complete or incomplete (scar tissue) healing of previous radiolucencies.
  
  
  RESULTS
  The PRP and PRP + collagen sponge groups depicted 83.33% and 88.89% healing, respectively, in terms of combined clinical-radiographic healing as compared with 80% in the collagen membrane group. All the three treatments showed highly significant (P < .05) reductions in the periodontal pocket depth (PD), the clinical attachment level (CAL), the gingival margin position (GMP), the size of the periapical lesion, the percentage reduction of the periapical rarefactions, and periapical healing. No significant differences between the three groups were evident for these parameters (P > .05).
  
  
  CONCLUSIONS
  GTR applied to apicomarginal defects using PRP or PRP + collagen sponge lead to similar enhancements of the clinical outcome of periradicular surgery in terms of periapical healing, gain of periodontal support, PD reduction, and PRP may be an alternative treatment for GTR membrane in the treatment of apicomarginal defects.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Government Dental College, Rohtak, Haryana, India.
authors.forename: Bhawna
authors.initials: B
authors.lastname: Goyal
authors.forename: Sanjay
authors.initials: S
authors.lastname: Tewari
authors.forename: Jigyasa
authors.initials: J
authors.lastname: Duhan
authors.forename: P K
authors.initials: PK
authors.lastname: Sehgal
mesh_terms: D000293:Adolescent; D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D001047:Apicoectomy / Q000379:methods; D001672:Biocompatible Materials; D003094:Collagen; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D010482:Periapical Abscess / Q000000981:diagnostic imaging / Q000601:surgery*; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D053657:Platelet-Rich Plasma / Q000502:physiology*; D011859:Radiography; D012184:Retrograde Obturation / Q000379:methods; D013524:Surgical Flaps; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; C488453:CollaCote; D008567:Membranes, Artificial; D003094:Collagen