title: Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery.
abstract: Poly(methyl methacrylate)-based bone cements are functionalized with mesoporous silica nanoparticles (MSN) to enable a highly efficient and sustained release of antibiotics to reduce the risk of post-operative joint infection. To overcome the limited drug release of 5% for only 1 day with the current commercial-grade bone cements, a 8 wt% MSN-formulated bone cement is able to increase the drug release efficiency by 14-fold and sustain the release for up to 80 days. The loaded MSN is suggested to build up an effective network of rod-shaped silica particles with uniformly arranged nanoporous channels, which is responsible for the effective drug diffusion and extend time-release to the external surfaces. MSN has no detrimental effect on the critical weight-bearing bending modulus and compression strength of bone cement. In vitro assay test results show a much sustained antibacterial effect and low cytotoxicity of MSN demonstrating the potential applicability of MSN-formulated bone cement.
authors.affiliation: Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore, 627833, Singapore. shen_shoucang@ices.a-star.edu.sg
authors.forename: Shou-Cang
authors.initials: SC
authors.lastname: Shen
authors.forename: Wai Kiong
authors.initials: WK
authors.lastname: Ng
authors.forename: Zhilong
authors.initials: Z
authors.lastname: Shi
authors.forename: Leonard
authors.initials: L
authors.lastname: Chia
authors.forename: Koon Gee
authors.initials: KG
authors.lastname: Neoh
authors.forename: Reginald Beng Hee
authors.initials: RB
authors.lastname: Tan
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D001672:Biocompatible Materials; D001843:Bone Cements / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects; D005839:Gentamicins / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D001843:Bone Cements; D005839:Gentamicins; D012822:Silicon Dioxide; D019904:Polymethyl Methacrylate