title: [Reactivation of hepatitis B in a patient with spondyloarthritis after the suspension of methotrexate and efficacy of treatment with antivirals in association to adalimumab].
abstract: We report the case of a male chronic hepatitis B virus (HBV) carrier with HLA-B27 spondyloarthrititis who developed fulminant hepatitis after discontinuation of methotrexate (MTX). Full recovery after therapy with lamivudine and adefovir allowed treatment with adalimumab which was well tolerated. Reactivation of hepatitis B after MTX withdrawal is a very rare complication, which can also occur in association with anti-TNF agents. In patients with positive serology for HBV prophylactic antiviral therapy is recommended.
authors.affiliation: Unidad de Reumatología, Hospital Royo Villanova, Zaragoza, España. jccobeta@hotmail.com
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Cobeta García
authors.forename: Marta
authors.initials: M
authors.lastname: Medrano
mesh_terms: D000068879:Adalimumab; D000225:Adenine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006509:Hepatitis B / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D019259:Lamivudine / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D063065:Organophosphonates / Q000627:therapeutic use; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000188:drug therapy*; D014775:Virus Activation
chemical_list: D000893:Anti-Inflammatory Agents; D061067:Antibodies, Monoclonal, Humanized; D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D063065:Organophosphonates; D019259:Lamivudine; C053001:adefovir; D000068879:Adalimumab; D000225:Adenine; D008727:Methotrexate