title: Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men.
abstract: Obesity is causally linked with the development of atherosclerosis. Omentin is an adipocytokine whose concentrations are reduced in obese individuals. Here we examined the relationship between plasma omentin levels and carotid intima-media thickness (IMT), a marker of early atherosclerosis, in apparently healthy Japanese men. Participants were 100 Japanese men who underwent a medical checkup. Maximal IMT (max-IMT) and mean-IMT in common carotid artery were measured by high-resolution carotid ultrasound system. Plasma omentin concentrations were determined by enzyme-linked immunosorbent assay. Circulating omentin levels correlated negatively with body mass index, waist circumference, fasting glucose, creatinine, max-IMT and mean-IMT, and positively with estimated glomerular filtration rates (eGFR). Single regression analysis demonstrated that max-IMT associated with age, eGFR and omentin levels, and that mean-IMT associated with age, fasting glucose, eGFR and omentin levels. Multiple regression analysis revealed that omentin levels, together with age, correlated with max-IMT and mean-IMT. Our data document that circulating omentin levels independently and negatively associate with carotid IMT in this population, suggesting that measurement of omentin may be useful for assessment of carotid IMT.
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Showa-Ku, Nagoya, Japan.
authors.forename: Rei
authors.initials: R
authors.lastname: Shibata
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Takahashi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kataoka
authors.forename: Koji
authors.initials: K
authors.lastname: Ohashi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Ikeda
authors.forename: Shinji
authors.initials: S
authors.lastname: Kihara
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ouchi
mesh_terms: D000375:Aging / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D059168:Carotid Intima-Media Thickness; D003404:Creatinine / Q000097:blood; D016207:Cytokines / Q000097:blood* / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood / Q000235:genetics; D005919:Glomerular Filtration Rate; D006801:Humans; D007564:Japan; D037102:Lectins / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D003404:Creatinine