title: Influence of the timing of malaria infection during pregnancy on birth weight and on maternal anemia in Benin.
abstract: Abstract. Although consequences of malaria in pregnancy are well known, the period of pregnancy in which infection has the highest impact is still unclear. In Benin, we followed up a cohort of 1,037 women through pregnancy until delivery. The objective was to evaluate the relationship between the timing of infection and birth weight, and maternal anemia at delivery. At the beginning of pregnancy, peripheral infections were associated with a decrease in mean birth weight (-98.5 g; P = 0.03) and an increase in the risk of anemia at delivery (adjusted odds ratio [aOR] = 1.6; P = 0.03). Infections in late pregnancy were related to a higher risk of maternal anemia at delivery (aOR = 1.7; P = 0.001). To fully protect the women during the whole pregnancy, already implemented measures (insecticide-treated nets and intermittent preventive treatment) should be reinforced. In the future, a vaccine against pregnancy-associated malaria parasites could protect the women in early pregnancy, which seems to be a high-risk period.
authors.affiliation: Institut de Recherche pour le Développement, Mère et Enfant Face aux Infections Tropicales, Paris, France. bichtrambe@hotmail.com
authors.forename: Bich-Tram
authors.initials: BT
authors.lastname: Huynh
authors.forename: Nadine
authors.initials: N
authors.lastname: Fievet
authors.forename: Gildas
authors.initials: G
authors.lastname: Gbaguidi
authors.forename: Sébastien
authors.initials: S
authors.lastname: Dechavanne
authors.forename: Sophie
authors.initials: S
authors.lastname: Borgella
authors.forename: Blaise
authors.initials: B
authors.lastname: Guézo-Mévo
authors.forename: Achille
authors.initials: A
authors.lastname: Massougbodji
authors.forename: Nicaise Tuikue
authors.initials: NT
authors.lastname: Ndam
authors.forename: Philippe
authors.initials: P
authors.lastname: Deloron
authors.forename: Michel
authors.initials: M
authors.lastname: Cot
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000209:etiology*; D001541:Benin / Q000453:epidemiology; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000473:pathology*; D008875:Middle Aged; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology / Q000473:pathology*; D011264:Pregnancy Trimesters; D055815:Young Adult