title: [The expression of PD4 and its significance in human laryngeal carcinoma].
abstract: OBJECTIVE
  To explore the expression of mycoplasma monoclonal antibody PD4 in different laryngeal carcinoma tissues and their clinical significance.
  
  
  METHODS
  Using immunohistochemistry methods to detect 256 cases of laryngeal tissues, including 105 cases of laryngeal carcinoma tissues, 31 cases of neck metastasis lymph node tissues, 18 cases of precarcinoma tissues, 53 cases of vocal cord polyps, 20 cases of normal tissues adjacent to laryngeal carcinoma and 29 cases of normal tissues around laryngeal carcinoma.
  
  
  RESULTS
  (1) The positive rate of PD4 was 44.76% in laryngeal carcinoma, which was much higher than that in other laryngeal tissues (P < 0.01 or P < 0.05). (2) The PD4 expression in laryngeal carcinoma was higher in the third and fourth stages than in the first and second stages, higher with cervical metastasis than those without cervical metastasis and higher in the third and second histological grade than in the first histological grade (P < 0.01 or P < 0.05). (3) To 3 and 5 years survival, PD4 positive cases had lower chance than PD4 negative cases (P < 0.01).
  
  
  CONCLUSIONS
  These results implicate that the occurrence, development and prognosis of laryngeal carcinoma may be closely related to mycoplasma infection.
authors.affiliation: Department of Otolaryngology, the First Affiliated Hospital of PLA General Hospital, Beijing, 100037, China. sunbaochun2009@sina.com
authors.forename: Baochun
authors.initials: B
authors.lastname: Sun
authors.forename: Shuwei
authors.initials: S
authors.lastname: Zhao
authors.forename: Chengyong
authors.initials: C
authors.lastname: Zhou
authors.forename: Dagen
authors.initials: D
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009175:Mycoplasma Infections; D009367:Neoplasm Staging; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D051017:Apoptosis Regulatory Proteins; C114487:PDCD4 protein, human; D016601:RNA-Binding Proteins