title: Sensing change: the emerging role of calcium sensors in neuronal disease.
abstract: Calcium (Ca(2+)) is a fundamental intracellular signalling molecule in neurons. Therefore, significant interest has been expressed in understanding how the dysregulation of Ca(2+) signals might impact on neuronal function and the progression of different disease states. Many previous studies have examined the role of Ca(2+) in neuronal excitotoxicity and some have started to understand how Ca(2+) dysregulation might be a cause or consequence of neurodegeneration. This review will therefore focus on the significance of Ca(2+) sensors, proteins that transduce Ca(2+) signals, in neuronal function and dysfunction. Finally, we will assess their potential role in neurodegenerative processes, such as Alzheimer's disease (AD), arguing that they could serve as potential therapeutic targets.
authors.affiliation: Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK.
authors.forename: Gillian
authors.initials: G
authors.lastname: Seaton
authors.forename: Ellen L
authors.initials: EL
authors.lastname: Hogg
authors.forename: Jihoon
authors.initials: J
authors.lastname: Jo
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Whitcomb
authors.forename: Kwangwook
authors.initials: K
authors.lastname: Cho
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D020832:EF Hand Motifs; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D051580:Neuronal Calcium-Sensor Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D051580:Neuronal Calcium-Sensor Proteins; D002118:Calcium