title: Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula.
abstract: Grassypeptolides F (1) and G (2), bis-thiazoline-containing cyclic depsipeptides with a rare β-amino acid, extensive N-methylation, and a large number of d-amino acids, are reported from an extract of the Palauan cyanobacterium Lyngbya majuscula. Both 1 and 2 were found to have moderate inhibitory activity against the transcription factor AP-1 (IC₅₀ = 5.2 and 6.0 μM, respectively).
authors.affiliation: Molecular Targets Laboratory, Center for Cancer Research, NCI-Frederick , Frederick, Maryland 21702-1124, USA.
authors.forename: Wendy L
authors.initials: WL
authors.lastname: Popplewell
authors.forename: Ranjala
authors.initials: R
authors.lastname: Ratnayake
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Wilson
authors.forename: John A
authors.initials: JA
authors.lastname: Beutler
authors.forename: Nancy H
authors.initials: NH
authors.lastname: Colburn
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Henrich
authors.forename: James B
authors.initials: JB
authors.lastname: McMahon
authors.forename: Tawnya C
authors.initials: TC
authors.lastname: McKee
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D018808:Transcription Factor AP-1 / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D047630:Depsipeptides; D018808:Transcription Factor AP-1; C561847:grassypeptolide F; C561848:grassypeptolide G