title: [Utilization of hyperestrogenic therapies in systemic lupus erythematosus].
abstract: The use of treatments that increase the estrogenic levels has been usually deemed risky in lupus patients. Past studies about the utilization of oral contraceptive drugs and hormone replacement therapy (HRT) have shown contradictory results. More recently, prospective studies about this issue suggest that either oral anticonceptive and HRT can be used in patients with stable disease without special risk for increments in clinical activity. Neither, it has been observed an association with the development of arterial or venous thrombosis. Although, to this regard, several methodological limitations preclude to establish definitive conclusions. Regarding to the use of assisted reproduction techniques in lupus patients, only retrospective data are available. Overall they indicate that the real risk of disease worsening is quite low, being the flares mostly mild when these procedures are performed in patients with stable disease.
authors.affiliation: Sección de Reumatología, Hospital General Sierrallana, IFIMAV, Universidad de Cantabria, Cantabria, España.
authors.forename: Jaime
authors.initials: J
authors.lastname: Calvo-Alén
authors.forename: Cristina
authors.initials: C
authors.lastname: Mata
authors.forename: Elena
authors.initials: E
authors.lastname: Aurrecoechea