title: Determination of photostability and photodegradation products of indomethacin in aqueous media.
abstract: Photochemical behaviour of indomethacin in aqueous media at 254nm, 310nm and sunlight was studied by HPLC. The drug exhibited a similar behaviour in all the irradiation experiments affording eight photoproducts that were separated and identified. The main photochemical routes are suggested to proceed via decarboxylation, followed by oxygenation to give an alcohol and an aldehyde and/or by solvent trapping to produce the alcohol. Photoinduced hydrolysis of CO-N bond and oxidative C2-C3 bond breakage also occur.
authors.affiliation: UDR Napoli 4 (Consorzio INCA), IC-REACH Dipartimento di Chimica Organica e Biochimica, Università Federico II, Complesso Universitario Monte S. Angelo, Via Cinthia 4, I-80126 Napoli, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Temussi
authors.forename: Flavio
authors.initials: F
authors.lastname: Cermola
authors.forename: Marina
authors.initials: M
authors.lastname: Dellagreca
authors.forename: M Rosaria
authors.initials: MR
authors.lastname: Iesce
authors.forename: Monica
authors.initials: M
authors.lastname: Passananti
authors.forename: Lucio
authors.initials: L
authors.lastname: Previtera
authors.forename: Armando
authors.initials: A
authors.lastname: Zarrelli
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D004355:Drug Stability; D006801:Humans; D006868:Hydrolysis; D007213:Indomethacin / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D010599:Pharmacokinetics; D010782:Photolysis; D010787:Photosensitivity Disorders / Q000378:metabolism; D012997:Solvents; D013472:Sunlight; D014466:Ultraviolet Rays; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000737:chemistry / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012997:Solvents; D014874:Water Pollutants, Chemical; D007213:Indomethacin