title: Metal ion mediated imprinting for electrochemical enantioselective sensing of L-histidine at trace level.
abstract: Enantioselective trace level sensing of l-histidine (limit of detection, 1.980 ngm L(-1), S/N=3) was feasible with the use of a typical, reproducible, and rugged complex imprinted polymer-based pencil graphite electrode, in aqueous samples. In the present instance, the Cu(2+) ion-mediated imprinting of l-histidine in an molecularly imprinted polymer motif actually helped upbringing electrocatalytic activity to respond an enhanced differential pulse anodic stripping voltammetric oxidation peak of l-histidine, without any cross-reactivity and false-positive, in real samples. The proposed sensor could be considered suitable for the practical applications in biomarking histedinemia, a disease associated with L-histidine metabolic disorders, in clinical settings.
authors.affiliation: Analytical Division, Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India. prof.bbpd@yahoo.com
authors.forename: Bhim Bali
authors.initials: BB
authors.lastname: Prasad
authors.forename: Deepak
authors.initials: D
authors.lastname: Kumar
authors.forename: Rashmi
authors.initials: R
authors.lastname: Madhuri
authors.forename: Mahavir Prasad
authors.initials: MP
authors.lastname: Tiwari
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry; D003429:Cross Reactions; D055664:Electrochemical Techniques / Q000379:methods*; D006639:Histidine / Q000032:analysis*; D008855:Microscopy, Electron, Scanning; D054802:Molecular Imprinting / Q000379:methods*; D015203:Reproducibility of Results; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism
chemical_list: D006639:Histidine; D003300:Copper