title: Illinois statewide dual kidney transplantation experience--are we appropriately selecting kidneys?
abstract: OBJECTIVE
  Dual kidney transplantation is a technique that some transplant centers have adopted to increase organ use. We investigated whether kidneys that were recovered and discarded were similar to those kidneys used for dual kidney transplantation.
  
  
  METHODS
  We reviewed all kidneys recovered, biopsied and placed on machine perfusion in the state of Illinois from January 2002 to October 2009. We selected those kidneys used in dual kidney transplant, and compared their characteristics to those of kidneys that were recovered and biopsied but ultimately discarded. The immediate and 1-year outcomes of the dual kidney transplant recipients were analyzed.
  
  
  RESULTS
  During the study period 60 dual transplants were performed while 94 kidney pairs were discarded. Overall donors from the used group had a lower mean creatinine clearance, older mean patient age, lower percentage of glomerulosclerosis, higher final flow rate and lower resistance. However, the comparison between those kidneys used successfully with 1-year graft survival and those discarded demonstrated only 3 less favorable parameters among the discarded group, namely a higher percentage of glomerulosclerosis (18.5% vs 13.9%, p=0.024), a higher degree of interstitial fibrosis and a higher final resistance (0.39 vs 0.31, p<0.001).
  
  
  CONCLUSIONS
  The considerable overlap in demographics, histology and perfusion parameters between used and discarded kidneys suggests that many kidneys that were recovered and discarded could have been used in dual kidney transplantation with acceptable outcomes. This highlights the need for further study of how kidneys are selected and used.
authors.affiliation: Department of Urology, Loyola University Medical Center, Maywood, IL 60153, USA. coryhugen@gmail.com
authors.forename: Cory M
authors.initials: CM
authors.lastname: Hugen
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Polcari
authors.forename: Ronald
authors.initials: R
authors.lastname: Skolek
authors.forename: Martin F
authors.initials: MF
authors.lastname: Mozes
authors.forename: John E
authors.initials: JE
authors.lastname: Milner
mesh_terms: D046148:Donor Selection / Q000592:standards*; D006801:Humans; D007087:Illinois; D016030:Kidney Transplantation / Q000379:methods*; D008875:Middle Aged; D014022:Tissue Survival; D009927:Tissue and Organ Procurement / Q000592:standards