title: Tissue at risk in the deep middle cerebral artery territory is critical to stroke outcome.
abstract: BACKGROUND
  The clinical efficacy of thrombolysis in stroke patients is explained by the increased rate of recanalization, which limits infarct growth. However, the efficacy could also be explained by the protection of specific sites of the brain. Here, we investigate where is this outcome-related tissue at risk using voxel-based analysis.
  
  
  METHODS
  We included 68 acute stroke patients with middle cerebral artery (MCA) occlusion on the admission MRI performed within 6 h of symptoms onset (H6) and 16 controls. MCA recanalization was assessed using the magnetic resonance angiography performed at day 1 (D1). Apparent diffusion coefficient (ADC) changes were analyzed using a voxel-based method between patients vs. controls group at admission (H6) in non-recanalized vs. recanalized and in 3-month poor vs. good outcome patients at D1.
  
  
  RESULTS
  Complete or partial MCA recanalization was observed in 52 of 68 patients. Good outcome at 3 months occurred in 40 patients (59%). In non-recanalized patients, ADC was decreased in the deep MCA and watershed arterial territory (the lenticular nucleus, internal capsule, and the overlying periventricular white matter). This decrease was not observed in recanalized patients at D1 or patients at H6. Fiber tracking suggested that the area is crossed by the cortico-spinal, cerebellar, and intra-hemispheric association tracts. Finally, this area almost co-localized with the area associated with poor outcome.
  
  
  CONCLUSIONS
  A clinically relevant area of tissue at risk may occur in patients with MCA infarcts at the level of deep white matter fiber tracts. These findings suggest that neuroprotection research should be refocused on white matter.
authors.affiliation: AP-HP, Urgences Cérébro-Vasculaires, Pitié-Salpêtrière Hospital, Paris, France. charlotte.rosso@gmail.com
authors.forename: Charlotte
authors.initials: C
authors.lastname: Rosso
authors.forename: Olivier
authors.initials: O
authors.lastname: Colliot
authors.forename: Romain
authors.initials: R
authors.lastname: Valabrègue
authors.forename: Sophie
authors.initials: S
authors.lastname: Crozier
authors.forename: Didier
authors.initials: D
authors.lastname: Dormont
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lehéricy
authors.forename: Yves
authors.initials: Y
authors.lastname: Samson
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000150:complications* / Q000175:diagnosis; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000175:diagnosis / Q000473:pathology*; D013997:Time Factors