title: [Expression of GSK3B gene in peripheral blood in patient with Parkinson's disease].
abstract: Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons. Detecting changes in gene expression in untreated de novo patients with PD is important for understanding disease pathogenesis and for identifying biomarkers for preclinical stage of PD. In this study we investigate expression of gene of Glycogen synthase kinase-3 beta (GSK3B) in the peripheral blood of different groups of patients with neurological diseases using reverse transcription reaction and real-time polymerase chain reaction (PCR). Our results suggest that the expression levels of GSK3B can't serve as a biomarker for early stages of PD.
authors.forename: E V
authors.initials: EV
authors.lastname: Filatova
authors.forename: M I
authors.initials: MI
authors.lastname: Shadrina
authors.forename: A V
authors.initials: AV
authors.lastname: Karabanov
authors.forename: P A
authors.initials: PA
authors.lastname: Slominskiĭ
authors.forename: S N
authors.initials: SN
authors.lastname: Illarioshkin
authors.forename: I A
authors.initials: IA
authors.lastname: Ivanova-Smolenskaia
authors.forename: S A
authors.initials: SA
authors.lastname: Limborskaia
mesh_terms: D000328:Adult; D000368:Aged; D042241:Early Diagnosis; D005260:Female; D015870:Gene Expression; D005819:Genetic Markers; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000175:diagnosis* / Q000235:genetics
chemical_list: D005819:Genetic Markers; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3