title: AD8-Brazil: cross-cultural validation of the ascertaining dementia interview in Portuguese.
abstract: Dementia is a global public health problem and detection in the primary care setting, particularly in developing countries, is challenging. The aim of this research was to produce the cross-cultural validation of the AD8 interview to the Brazilian Portuguese Language. The original version of the AD8 was submitted to translation, back-translation, and application of the questionnaire to 20 elderly informants for face validation. The AD8-Brazil was then evaluated in 109 community-dwelling elderly with a sociodemographic questionnaire, clinical examination, Mini Mental State Examination (MMSE), Katz Inventory of Activities of Daily Living (ADL), and Clinical Dementia Rating scale (CDR). The AD8-Brazil was compared with the other instruments and with the clinical diagnosis (DSM-IV) for criterion validation. There was significant agreement of AD8-Brazil with diagnosis of dementia (p < 0.001), MMSE (p = 0.047), and ADL (PFisher = 0.004). Also, the AD8-Brazil was able to differentiate the stages of dementia by CDR scale. The reliability was high (alpha = 0.818) and reproducibility analysis showed excellent inter-rater (kappa = 0.889) and test-retest consistency (kappa = 0.814). The AD8-Brazil showed excellent discrimination between CDR 0 and CDR > 0 (area under the curve 86.1%) and between CDR 0 and CDR 0.5 (area under the curve 76.9%). The administration of the questionnaire took 2.3 ± 0.1 minutes. The Brazilian version of the AD8 is a valid, reliable, quick, and easy screening instrument for dementia.
authors.affiliation: University of Pernambuco, Recife, Pernambuco, Brazil. claricecorreia@hotmail.com
authors.forename: Clarice Câmara
authors.initials: CC
authors.lastname: Correia
authors.forename: Fábia
authors.initials: F
authors.lastname: Lima
authors.forename: Franco
authors.initials: F
authors.lastname: Junqueira
authors.forename: Marília Siqueira
authors.initials: MS
authors.lastname: Campos
authors.forename: Othon
authors.initials: O
authors.lastname: Bastos
authors.forename: Kátia
authors.initials: K
authors.lastname: Petribú
authors.forename: Jerson
authors.initials: J
authors.lastname: Laks
authors.forename: James E
authors.initials: JE
authors.lastname: Galvin
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000208:ethnology; D003072:Cognition Disorders / Q000209:etiology; D003431:Cross-Cultural Comparison; D003704:Dementia / Q000150:complications / Q000175:diagnosis* / Q000208:ethnology; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D009483:Neuropsychological Tests; D011174:Portugal / Q000208:ethnology; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D015203:Reproducibility of Results