title: Pharmacokinetics of hydroxycamptothecin nanosuspensions in rats.
abstract: The purpose of the present study was to investigate the pharmacokinetics of hydroxycamptothecin nanosuspensions after intravenous administration in rats. Hydroxycamptothecin injection was studied parallelly. The results showed that AUC(0 --> infinity), MRT, t1/2(alpha) and t1/2(beta) of hydroxycamptothecin nanosuspensions was significantly higher, while their total body clearance was lower than those of hydroxycamptothecin injections. The results indicate that hydroxycamptothecin nanosuspensions significantly increase hydroxycamptothecin blood concentrations and retention within the systemic circulation.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Hua
authors.forename: Wei-Jing
authors.initials: WJ
authors.lastname: Liu
authors.forename: Yong-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D006207:Half-Life; D007275:Injections, Intravenous; D053758:Nanoparticles; D051381:Rats; D017208:Rats, Wistar; D013535:Suspensions
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013535:Suspensions; C028098:10-hydroxycamptothecin; D002166:Camptothecin