title: Prospective study of the ARCHITECTHIV Ag/Ab Combo fourth generation assay to detect HIV infection in sexually transmitted infection clinics.
abstract: This prospective, cross-sectional study of HIV testing at two sexually transmitted infection clinics compares testing results from the ARCHITECT HIV Ag/Ab Combo fourth generation assay against the current standard of care in North Carolina (third generation enzyme immunoassay testing with western blot confirmation and reflex nucleic acid amplification testing of pooled seronegative samples). In this setting, the assay reported a sensitivity of 100%, a specificity of 99.9%, and a median turn-around time of 26.1 h.
authors.affiliation: University of North Carolina at Chapel Hill, USA.
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Bischof
authors.forename: JoAnn D
authors.initials: JD
authors.lastname: Kuruc
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Embry
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Hatch
authors.forename: Faith A
authors.initials: FA
authors.lastname: Ashton
authors.forename: John L
authors.initials: JL
authors.lastname: Schmitz
authors.forename: William C
authors.initials: WC
authors.lastname: Miller
authors.forename: Peter A
authors.initials: PA
authors.lastname: Leone
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Gay
mesh_terms: D000554:Ambulatory Care Facilities; D015153:Blotting, Western; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000175:diagnosis*; D006801:Humans; D007118:Immunoassay; D008297:Male; D021141:Nucleic Acid Amplification Techniques; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D015229:Sexually Transmitted Diseases, Viral / Q000175:diagnosis*