title: Effects of intracellular acidosis on endothelial function: an overview.
abstract: The endothelium represents the largest functional organ in the human body playing an active role in vasoregulation, coagulation, inflammation, and microvascular permeability. Endothelium contributes to maintain vascular integrity, intravascular volume, and tissue oxygenation promoting inflammatory network response for local defense and repair. Acid-basis homeostasis is an important physiologic parameter that controls cell function, and changes in pH can influence vascular tone by regulating endothelium and vascular smooth muscle cells. This review presents a current perspective of the effects of intracellular acidosis on the function and the basic regulatory mechanisms of endothelial cells.
authors.affiliation: Department of Anesthesia and Critical Care Medicine, Shands Hospital, University of Florida, Gainesville, FL 32608, USA.
authors.forename: Ettore
authors.initials: E
authors.lastname: Crimi
authors.forename: Fabio Silvio
authors.initials: FS
authors.lastname: Taccone
authors.forename: Teresa
authors.initials: T
authors.lastname: Infante
authors.forename: Sabino
authors.initials: S
authors.lastname: Scolletta
authors.forename: Valeria
authors.initials: V
authors.lastname: Crudele
authors.forename: Claudio
authors.initials: C
authors.lastname: Napoli
mesh_terms: D000138:Acidosis / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D027982:Sodium-Bicarbonate Symporters / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
chemical_list: D027982:Sodium-Bicarbonate Symporters; D017923:Sodium-Hydrogen Exchangers; D002118:Calcium