title: Digital optical tomography system for dynamic breast imaging.
abstract: Diffuse optical tomography has shown promising results as a tool for breast cancer screening and monitoring response to chemotherapy. Dynamic imaging of the transient response of the breast to an external stimulus, such as pressure or a respiratory maneuver, can provide additional information that can be used to detect tumors. We present a new digital continuous-wave optical tomography system designed to simultaneously image both breasts at fast frame rates and with a large number of sources and detectors. The system uses a master-slave digital signal processor-based detection architecture to achieve a dynamic range of 160 dB and a frame rate of 1.7 Hz with 32 sources, 64 detectors, and 4 wavelengths per breast. Included is a preliminary study of one healthy patient and two breast cancer patients showing the ability to identify an invasive carcinoma based on the hemodynamic response to a breath hold.
authors.affiliation: Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, New York 10027, USA. mlf2129@columbia.edu
authors.forename: Molly L
authors.initials: ML
authors.lastname: Flexman
authors.forename: Michael A
authors.initials: MA
authors.lastname: Khalil
authors.forename: Rabah
authors.initials: R
authors.lastname: Al Abdi
authors.forename: Hyun K
authors.initials: HK
authors.lastname: Kim
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Fong
authors.forename: Elise
authors.initials: E
authors.lastname: Desperito
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Hershman
authors.forename: Randall L
authors.initials: RL
authors.lastname: Barbour
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Hielscher
mesh_terms: D000328:Adult; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000503:physiopathology; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply / Q000175:diagnosis / Q000503:physiopathology; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D004867:Equipment Design; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008875:Middle Aged; D055100:Optical Fibers; D015656:Respiratory Mechanics; D012815:Signal Processing, Computer-Assisted; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D014584:User-Computer Interface