title: Parcellation in left lateral parietal cortex is similar in adults and children.
abstract: A key question in developmental neuroscience involves understanding how and when the cerebral cortex is partitioned into distinct functional areas. The present study used functional connectivity MRI mapping and graph theory to identify putative cortical areas and generate a parcellation scheme of left lateral parietal cortex (LLPC) in 7 to 10-year-old children and adults. Results indicated that a majority of putative LLPC areas could be matched across groups (mean distance between matched areas across age: 3.15 mm). Furthermore, the boundaries of children's putative LLPC areas respected the boundaries generated from the adults' parcellation scheme for a majority of children's areas (13/15). Consistent with prior research, matched LLPC areas showed age-related differences in functional connectivity strength with other brain regions. These results suggest that LLPC cortical parcellation and functional connectivity mature along different developmental trajectories, with adult-like boundaries between LLPC areas established in school-age children prior to adult-like functional connectivity.
authors.affiliation: Department of Neurology, Washington University, St. Louis, MO 63110, USA. kelly.barnes@nih.gov
authors.forename: Kelly Anne
authors.initials: KA
authors.lastname: Barnes
authors.forename: Steven M
authors.initials: SM
authors.lastname: Nelson
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Cohen
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Power
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Coalson
authors.forename: Francis M
authors.initials: FM
authors.lastname: Miezin
authors.forename: Alecia C
authors.initials: AC
authors.lastname: Vogel
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Dubis
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Church
authors.forename: Steven E
authors.initials: SE
authors.lastname: Petersen
authors.forename: Bradley L
authors.initials: BL
authors.lastname: Schlaggar
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002648:Child; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology; D010296:Parietal Lobe / Q000033:anatomy & histology* / Q000254:growth & development* / Q000502:physiology*; D055815:Young Adult