title: PKC-delta and PKC-epsilon: foes of the same family or strangers?
abstract: Protein kinase C (PKC) is a family of 10 serine/threonine kinases divided into 3 subfamilies, classical, novel and atypical classes. Two PKC isozymes of the novel group, PKCε and PKCδ, have different and sometimes opposite effects. PKCε stimulates cell growth and differentiation while PKCδ is apoptotic. In the heart, they are among the most expressed PKC isozymes and they are opposed in the preconditioning process with a positive role of PKCε and an inhibiting role of PKCδ. The goal of this review is to analyze the structural differences of these 2 enzymes that may explain their different behaviors and properties.
authors.affiliation: INSERM, UMR_S915, l'institut du thorax, Nantes, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Duquesnes
authors.forename: Frank
authors.initials: F
authors.lastname: Lezoualc'h
authors.forename: Bertrand
authors.initials: B
authors.lastname: Crozatier
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism* / Q000473:pathology; D007527:Isoenzymes / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009928:Organ Specificity; D011485:Protein Binding; D051571:Protein Kinase C-alpha / Q000737:chemistry / Q000378:metabolism; D051745:Protein Kinase C-delta / Q000737:chemistry / Q000378:metabolism; D051744:Protein Kinase C-epsilon / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011817:Rabbits; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; D051571:Protein Kinase C-alpha; D051745:Protein Kinase C-delta; D051744:Protein Kinase C-epsilon; D013755:Tetradecanoylphorbol Acetate