title: [RANKL/RANK signaling in rheumatoid arthritis].
abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease, which is induced by abundant inflammatory cytokines releasing from synovial fibroblasts and T lymphocytes. These cytokines differentiate monocyte-macrophage lineage cells to mature osteoclasts, which cause bone resorption and then joint destruction. RANKL is involved in the development of osteoclasts, cooperating with another key molecule, M-CSF. Indeed, RANKL is over-expressed in the synovium of RA. We summarize RANKL/RANK signaling in RA, including recent therapeutic topics.
authors.affiliation: Department of Orthopaedic Surgery, The University of Tokyo, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Omata
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D001862:Bone Resorption; D002454:Cell Differentiation; D016207:Cytokines / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D016173:Macrophage Colony-Stimulating Factor / Q000378:metabolism; D008264:Macrophages / Q000166:cytology; D058990:Molecular Targeted Therapy; D009000:Monocytes / Q000166:cytology; D010010:Osteoclasts / Q000502:physiology; D053245:RANK Ligand / Q000502:physiology*; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013583:Synovial Membrane / Q000378:metabolism
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; D016173:Macrophage Colony-Stimulating Factor