title: Synthesis and cytotoxic activities of new fatty acid esters of 20(S)-protopanaxadiol.
abstract: In order to find new lead compounds with antitumour activies, thirteen new fatty acid esters of 20(S)-protopanaxadiol (PPD) were synthesized using oleoyl chloride or fatty acids and N,N'-dicyclohexylcarbodiimide (DCC). Their cytotoxic activities were tested using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] method, and the structure-activity relationships between the fatty acid esters of PPD and their cytotoxic activities are discussed.
authors.affiliation: School of Traditional Chinese Materia Medica 49#, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China. liningsypharm@163.com
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Wan
authors.initials: W
authors.lastname: Xiao
authors.forename: Jinping
authors.initials: J
authors.lastname: Liu
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Pingya
authors.initials: P
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004952:Esters; D005227:Fatty Acids / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012502:Sapogenins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004952:Esters; D005227:Fatty Acids; D012502:Sapogenins; C062916:protopanaxadiol