title: Vascular risk factors and dementia: 40-year follow-up of a population-based cohort.
abstract: OBJECTIVE
  Our aim was to evaluate the longitudinal associations of individual and multiple vascular risk factors with the subsequent development of dementia and Alzheimer's disease (AD).
  
  
  METHODS
  The Uppsala Longitudinal Study of Adult Men started in 1970 when the 2,268 participants were 50 years old. Baseline investigations included determinations of blood pressure, fasting glucose, cholesterol, BMI and smoking status. Over a maximum follow-up of 40 years, 349 participants were diagnosed with dementia, out of which 127 had AD. Analyses were repeated using a re-examination of the cohort at 70 years of age as a baseline.
  
  
  RESULTS
  No associations between vascular risk factors and AD were found. For all-type dementia, the association between high systolic blood pressure and dementia was the most consistent. High fasting glucose was associated with increased risk of all-type dementia only when measured at 70 years. Individuals with both an APOE ε4 allele and vascular risk factors had the greatest dementia risk.
  
  
  CONCLUSIONS
  Vascular risk factors influence the future risk of dementia, in particular vascular and mixed-type rather than AD. The impact of vascular risk factors on dementia in a longitudinal study depends on the age at baseline and the length of follow-up.
authors.affiliation: Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Science Park, Uppsala, Sweden. elina.ronnemaa@pubcare.uu.se
authors.forename: Elina
authors.initials: E
authors.lastname: Rönnemaa
authors.forename: Björn
authors.initials: B
authors.lastname: Zethelius
authors.forename: Lars
authors.initials: L
authors.lastname: Lannfelt
authors.forename: Lena
authors.initials: L
authors.lastname: Kilander
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology*; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D003704:Dementia / Q000150:complications / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011153:Population; D016016:Proportional Hazards Models; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013548:Sweden / Q000453:epidemiology
chemical_list: D001057:Apolipoproteins E; D001786:Blood Glucose; D002784:Cholesterol