title: ADRB1 as a potential target for gene therapy of pregnancy induced hypertension and gestational diabetes mellitus.
abstract: Pregnancy-induced hypertension (PIH) and gestational diabetes mellitus (GDM) do not cause any problems with recognition; however, their pathophysiologies are still not explained. Yet many authors suggest that adrenergic β-1 receptor (ADRB1) plays a crucial role. The aim of this study was to evaluate the transcription activity of ADRB1 by using real-time polymerase chain reaction (PCR) in placenta from normal pregnancies and from PIH and GDM. Obtained findings demonstrated a significant increase in ADRB1 mRNA expression in the examined groups in comparison to the control (p = 0.03). Our data indicate a potential perspective of ADRB1 suppression gene therapy in the treatment of PIH and GDM.
authors.affiliation: Department of Molecular Biology, Medical University of Silesia, Katowice, Poland. awieclawek@op.pl
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wieclawek
authors.forename: Helena
authors.initials: H
authors.lastname: Slawska
authors.forename: Urszula
authors.initials: U
authors.lastname: Mazurek
mesh_terms: D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D015316:Genetic Therapy; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000503:physiopathology / Q000628:therapy*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology / Q000628:therapy*; D012333:RNA, Messenger / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: C547787:ADRB1 protein, human; D012333:RNA, Messenger; D018342:Receptors, Adrenergic, beta-1