title: Screening of estrogenic and antiestrogenic activities from medicinal plants.
abstract: The medicinal plant extracts commercially used in Asia were screened for their estrogenic and antiestrogenic activities in a recombinant yeast system featuring both a human estrogen receptor (ER) expression plasmid and a reporter plasmid. Pueraria lobata (flower) had the highest estrogenic relative potency (RP, 7.75×10(-3); RP of 17β-estradiol=1), followed by Amomum xanthioides (1.25×10(-3)). Next potent were a group consisting of Glycyrrhiza uralensis, Zingiber officinale, Rheum undulatum, Curcuma aromatica, Eriobotrya japonica, Sophora flavescens, Anemarrhena asphodeloides, Polygonum multiflorum, and Pueraria lobata (root) (ranging from 9.5×10(-4) to 1.0×10(-4)). Least potent were Prunus persica, Lycoppus lucidus, and Adenophora stricta (ranging from 9.0×10(-5) to 8.0×10(-5)). The extracts exerting antiestrogenic effects, Cinnamomum cassia and Prunus persica, had relative potencies of 1.14×10(-3) and 7.4×10(-4), respectively (RP of tamoxifen=1). The solvent fractions from selected estrogenic or antiestrogenic herbs had higher estrogenic relative potencies, with their RP ranging from 9.3×10(-1) to 2.7×10(-4) and from 8.2×10(-1) to 9.1×10(-3), respectively. These results support previous reports on the efficacy of Oriental medicinal plants used or not used as phytoestrogens for hormone replacement therapy.
authors.affiliation: Department of Radiation Biology, Environment Radiation Research Group, Korea Atomic Energy Research Institute, Daejeon, Republic of Korea.
authors.forename: In Gyu
authors.initials: IG
authors.lastname: Kim
authors.forename: Se Chan
authors.initials: SC
authors.lastname: Kang
authors.forename: Kug Chan
authors.initials: KC
authors.lastname: Kim
authors.forename: Eui Su
authors.initials: ES
authors.lastname: Choung
authors.forename: Ok Pyo
authors.initials: OP
authors.lastname: Zee