title: Clinical outcomes of patients with plasma cell leukemia in the era of novel therapies and hematopoietic stem cell transplantation strategies: a single-institution experience.
abstract: BACKGROUND
  PCL carries a poor prognosis and the optimal management remains unknown.
  
  
  METHODS
  To evaluate the outcome of patients with PCL in the era of novel agents and innovative transplantation strategies, we conducted a review of patients with PCL who were treated at our institution from August 2003 to October 2009. Our primary endpoint was to determine overall survival, which was calculated from time of PCL diagnosis to death or last follow-up. Secondary endpoints included response rates and analyses regarding how the novel agents and presence of adverse cytogenetic analyses affected outcomes.
  
  
  RESULTS
  We identified 25 patients with PCL (13 with primary PCL [pPCL], 12 with secondary PCL [sPCL]) from our institution. Eighteen patients received bortezomib-based regimens, 19 received high-dose melphalan followed by autologous hematopoietic stem cell transplantation (HCT), and 6 underwent allogeneic HCT. The median overall survival for all patients was 23.6 months. Bortezomib-treated patients had a median survival of 28.4 months vs. 4.0 months for the non-bortezomib-treated group (P < .001).
  
  
  CONCLUSIONS
  Our analysis suggests that patients with PCL who were treated with bortezomib and/or allogeneic HCT had improved outcomes.
authors.affiliation: Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Lebovic
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Melissa
authors.initials: M
authors.lastname: Alsina
authors.forename: Taiga
authors.initials: T
authors.lastname: Nishihori
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Shain
authors.forename: Daniel
authors.initials: D
authors.lastname: Sullivan
authors.forename: Jose L
authors.initials: JL
authors.lastname: Ochoa-Bayona
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Kharfan-Dabaja
authors.forename: Rachid
authors.initials: R
authors.lastname: Baz
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome