title: Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa.
abstract: We report treatment outcomes from a retrospective cohort of patients with isoniazid-monoresistant tuberculosis in rural South Africa. Sixteen percent of patients had poor outcomes, 61% of whom progressed to multidrug-resistant tuberculosis. These data reveal the need for early identification and aggressive follow-up of isoniazid monoresistance to increase treatment success.
authors.affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. krjacobson@partners.org
authors.forename: Karen R
authors.initials: KR
authors.lastname: Jacobson
authors.forename: Danie
authors.initials: D
authors.lastname: Theron
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Victor
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Streicher
authors.forename: Robin M
authors.initials: RM
authors.lastname: Warren
authors.forename: Megan B
authors.initials: MB
authors.lastname: Murray
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000235:genetics; D002374:Catalase / Q000235:genetics; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics; D012189:Retrospective Studies; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D002374:Catalase; C480353:katG protein, Mycobacterium tuberculosis; D007538:Isoniazid