title: [Clinical and functional disorders of the stomach-in patients with psoriasis in the presence of chronic opisthorchiasis].
abstract: OBJECTIVE
  to study the clinical and functional status of the stompach in patients with psoriasis in the presence of chronic opisthorchiasis (CO). Subjects and methods. Ninety patients with psoriasis concurrent with CO (a study group (Group 1)), 70 with psoriasis (a comparison group (Group 2)), 70 with CO (Group 3), and 30 healthy individuals were examined. All the patients underwent fractional gastric secretory studies and esophagogastroduodenoscopy (EGDS).
  
  
  RESULTS
  The study group showed a reduction in stimulated hydrochloric acid output (4.25+/-0.38 mmol/hour), which was significantly less than that in Groups 2 and 3 and healthy individuals [5.87+/-0.51 (p<0.001); 6.86+/-0.59 (p<0.05), and 10.73+/-0.84 mmnol/hour (p<0.001), respectively]. In the study group, stimulated pepsin output (4.87+/-0.49 mmol/hour) was also significantly less than that in the other groups. Reduced basal hydrochloric acid output was found in 65.5% of the study group patients, whose number was significantly larger than that in the comparison group [44.3% (p<0.05)] and its stimulated output was less in 80 and 62.9% in the study and comparison groups, respectively (p < 0.05). A reduction in pepsin output in the basal secretion phase was revealed in 57.8 and 37.1% of the patients in the study and comparison groups, respectively (p<0.05) while that in the stimulated phase was in 63.3 and 34.3% (p<0.001). Thus, gastric secretory function in psoriatic patients is characterized by reduced hydrochloric acid and pepsin outputs and it is more impaired in patients with mixed pathology, which necessitates anthelmintic therapy in this category of patients.
authors.forename: S A
authors.initials: SA
authors.lastname: Khardikova
authors.forename: É I
authors.initials: ÉI
authors.lastname: Beloborodova
mesh_terms: D002908:Chronic Disease; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D006851:Hydrochloric Acid / Q000378:metabolism; D009889:Opisthorchiasis / Q000378:metabolism / Q000503:physiopathology*; D010434:Pepsin A / Q000378:metabolism; D011565:Psoriasis / Q000378:metabolism / Q000469:parasitology* / Q000503:physiopathology*; D013270:Stomach / Q000469:parasitology / Q000503:physiopathology*
chemical_list: D010434:Pepsin A; D006851:Hydrochloric Acid