title: Gene expression profiles in liver of zebrafish treated with microcystin-LR.
abstract: Microcystin-LR (MC-LR) is the most frequently studied cyclic heptatoxin produced by cyanobacteria, which has tremendous negative impacts on fish, while its molecular mechanism behind remained unclear at present. Here, Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafish (Danio rerio) after MC-LR exposure. Among the 14,900 transcripts in the microarray, 273 genes were differentially expressed, in which 243 genes were elevated and 30 were decreased. According to GOstat analysis, MC-LR mainly influenced the cell cycle and mitogen-activated protein kinases (MAPK) signaling pathways. In addition, many immune-related genes were also influenced. These data suggest that MC-LR could promote tumorigenesis and cause immunotoxicity in fish.
authors.affiliation: College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei Province 430070, China; State Key Laboratory of Freshwater Ecology and Biotechnology, and Laboratory of Fish Diseases, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province 430072, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Wei
authors.forename: Baojian
authors.initials: B
authors.lastname: Sun
authors.forename: Lirong
authors.initials: L
authors.lastname: Song
authors.forename: Pin
authors.initials: P
authors.lastname: Nie