title: Quantifying the effects of iodine contrast media on standardised uptake values of FDG PET/CT images: an anthropomorphic phantom study.
abstract: This study aimed to quantify the amount of change in Standardised Uptake Values (SUVs) of PET/CT images by simulating the set-up as closely as possible to the actual patient scanning. The experiments were conducted using an anthropomorphic phantom, which contained an amount of radioactivity in the form of Fluorodeoxyglucose (FDG) in a primary plastic test tube and one litre saline bags, including the insertion of bony structures and another two test tubes containing different concentrations of iodine contrast media. Standard scanning protocols were employed for the PET/CT image acquisition. The highest absolute differences in the SUVmax and SUVmean values of the saline bags were found to be about 0.2 and 0.4, respectively. The primary test tube showed the largest change of 1.5 in both SUVs; SUV max and SUVmean. However, none of these changes were found to be statistically significant. The clinical literature also contains no evidence to suggest that the changes of this magnitude would change the final diagnosis. Based on these preliminary data, we propose that iodine contrast media can be used during the CT scan of PET/CT imaging, without significantly affecting the diagnostic quality of this integrated imaging modality.
authors.affiliation: Discipline of Medical Radiations, School of Medical Sciences, Bundoora West Campus, RMIT University, VIC 3083, Australia.
authors.forename: Hairil Rashmizal
authors.initials: HR
authors.lastname: Abdul Razak
authors.forename: Abdul Jalil
authors.initials: AJ
authors.lastname: Nordin
authors.forename: Trevor
authors.initials: T
authors.lastname: Ackerly
authors.forename: Bruce
authors.initials: B
authors.lastname: Van Every
authors.forename: Ruth
authors.initials: R
authors.lastname: Martin
authors.forename: Moshi
authors.initials: M
authors.lastname: Geso
mesh_terms: D003287:Contrast Media; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007455:Iodine; D064847:Multimodal Imaging / Q000379:methods* / Q000592:standards; D009369:Neoplasms / Q000175:diagnosis; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D019788:Fluorodeoxyglucose F18; D007455:Iodine