title: Relationship between inhibin-α gene polymorphisms and premature ovarian failure in Korean women.
abstract: OBJECTIVE
  The aim of this study was to determine the relationship between inhibin-α (INHα) gene polymorphisms and the prevalence of premature ovarian failure (POF) in Korean women.
  
  
  METHODS
  The INHα -124A/G, -16C/T, 679G/A, and 769G/A polymorphisms were analyzed in 52 women with POF and 55 normal healthy women using polymerase chain reaction-restriction enzyme fragment length polymorphism analysis.
  
  
  RESULTS
  The 679G/A and 769G/A polymorphisms were not observed. The frequencies of the C allele of the INHα -16C/T polymorphism and the G allele of the INHα -124A/G polymorphism were significantly lower in the women with POF than in the normal control women. The frequencies of the CG haplotype allele of these INHα -16C/T and -124A/G gene polymorphisms were also significantly lower in the women with POF than in the control women.
  
  
  CONCLUSIONS
  The INHα -16C/T and -124A/G polymorphisms are genetic factors associated with the prevalence of POF in Korean women.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Kim
authors.forename: Sungwook
authors.initials: S
authors.lastname: Chun
authors.forename: Bon Seon
authors.initials: BS
authors.lastname: Gu
authors.forename: Seung-Yup
authors.initials: SY
authors.lastname: Ku
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Jung Gu
authors.initials: JG
authors.lastname: Kim
mesh_terms: D005260:Female; D006239:Haplotypes; D006801:Humans; D007265:Inhibins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D056910:Republic of Korea
chemical_list: C094377:inhibin-alpha subunit; D007265:Inhibins