title: Electrochemical oxidation behavior of colchicine on a graphene oxide-Nafion composite film modified glassy carbon electrode.
abstract: An electrochemical sensor, based on a graphene oxide (GO)-Nafion composite film modified glassy carbon electrode (GCE), was developed and used for detection of trace amounts of colchicine. Owing to the large surface area, good conductivity of GO and good affinity of Nafion, the sensor exhibited excellent electrocatalytic activity for the oxidation of colchicine, displaying a wide linear response from 5.0 × 10(-8) to 2.0 × 10(-5) mol L(-1) and a low detection limit of 1.5 × 10(-8) mol L(-1) in 0.1 mol L(-1) H(2)SO(4) solution. And this modified electrode exhibited a superior immunity from epinephrine, dopamine and ascorbic acid interference. The method was also applied successfully to detect colchicine in medicinal tablets.
authors.affiliation: Department of Chemistry, Zhengzhou University, Zhengzhou, 450052, P. R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: ShengJiang
authors.initials: S
authors.lastname: Wu
authors.forename: Ge
authors.initials: G
authors.lastname: Song
authors.forename: Baoxian
authors.initials: B
authors.lastname: Ye
mesh_terms: D002244:Carbon / Q000737:chemistry*; D003078:Colchicine / Q000032:analysis* / Q000737:chemistry*; D004553:Electric Conductivity; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D005465:Fluorocarbon Polymers / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D008567:Membranes, Artificial; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D005465:Fluorocarbon Polymers; D008567:Membranes, Artificial; D010087:Oxides; C040402:perfluorosulfonic acid; D002244:Carbon; D003078:Colchicine