title: Phosphoinositides and the regulation of tubular-based endosomal sorting.
abstract: From the pioneering work of Mabel and Lowell Hokin in the 1950s, the biology of this specific isomer of hexahydroxycyclohexane and its phosphorylated derivatives, in the form of inositol phosphates and phosphoinositides, has expanded to fill virtually every corner of cell biology, whole-organism physiology and development. In the present paper, I give a personal view of the role played by phosphoinositides in regulating the function of the endosomal network, and, in so doing, highlight some of the basic properties through which phosphoinositides regulate cell function.
authors.affiliation: Henry Wellcome Integrated Signalling Laboratories, School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK. Pete.Cullen@bristol.ac.uk
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Cullen
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008968:Molecular Conformation; D010716:Phosphatidylinositols / Q000737:chemistry / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D009626:Terminology as Topic; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: D010716:Phosphatidylinositols; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins