title: Linear IgA disease: complicated by alpha thalassemia.
abstract: Dapsone is regarded as the treatment of choice for linear immunoglobulin A disease (chronic bullous disease of childhood). It is associated with both hemolytic anemia and methemoglobinemia. The hematotoxic effects are dose related and can result in significant hemolysis. We present a case of a patient with chronic bullous disease of childhood and alpha thalassemia trait. Complete resolution occurred on a standard dose of dapsone without significant hemolysis.
authors.affiliation: National Naval Medical Center, Bethesda, Maryland 20889, USA. melissa.scorza@med.navy.mil
authors.forename: Melissa
authors.initials: M
authors.lastname: Scorza
authors.forename: Kenneth
authors.initials: K
authors.lastname: Galeckas
mesh_terms: D002675:Child, Preschool; D002908:Chronic Disease; D003622:Dapsone / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome; D017085:alpha-Thalassemia / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics
chemical_list: D003879:Dermatologic Agents; D007070:Immunoglobulin A; D003622:Dapsone; D011239:Prednisolone