title: [Changes in expression of the genes for chemokines, cytokines, and their receptors in response to selank and its fragments].
abstract: A study of the immunomodulating effect of selank showed that the total peptide and its fragment significantly change the expression of the genes for chemokines, cytokines, and their receptors in mouse spleen 6 and 24 h after administration of a single dose. Changes in the mRNA level of the majority of the genes under study were similarly observed after the administration of Gly-Pro, which was earlier identified as a selank pharmacophor, a minimum fragment with anitiviral activity. Pharmacological preparations based on endogenous regulatory peptides are studied intensely because they are the most promising class of drugs and have almost no side effects. The class includes selank, which is a synthetic analog of taftsin. Selank exerts anxiolytic and nootropic effects and, on the other hand, has pronounced antiviral properties.
authors.forename: T A
authors.initials: TA
authors.lastname: Kolomin
authors.forename: M I
authors.initials: MI
authors.lastname: Shadrina
authors.forename: P A
authors.initials: PA
authors.lastname: Slominskiĭ
authors.forename: S  A
authors.initials: S
authors.lastname: Limborskaia
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D018925:Chemokines / Q000235:genetics*; D016207:Cytokines / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects*; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D018697:Nootropic Agents / Q000737:chemistry / Q000494:pharmacology*; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics; D018121:Receptors, Cytokine / Q000235:genetics; D014405:Tuftsin / Q000737:chemistry / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D000998:Antiviral Agents; D018925:Chemokines; D016207:Cytokines; D007155:Immunologic Factors; D018697:Nootropic Agents; D009842:Oligopeptides; D012333:RNA, Messenger; D018121:Receptors, Cytokine; D014405:Tuftsin; C100827:TP 7