title: A facile and one pot synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from terminal alkynes and phenacyl azides prepared from styrenes by CAN oxidant and sodium azide.
abstract: A facile and green synthesis of 1,4-disubstituted-1H-1,2,3-triazoles is reported. The reaction of α-azido ketones and terminal alkynes in the presence of [CuSO(4) (H(2)O)(5)/sodium ascorbate] in a mixture of H(2)O/polyethylene glycol 400 as solvent afforded the corresponding 1,4-disubstituted triazoles at ambient temperature with short reaction times and at high yields. The corresponding α-azido ketones were directly prepared in situ from various substituted styrenes using the oxidant cerium ammonium nitrate and sodium azide in oxygen-saturated methanol.
authors.affiliation: Department of Chemistry, Faculty of Sciences, Shahid Chamran University, Ahvaz 61357-4-3169, Iran.
authors.forename: Mosadegh
authors.initials: M
authors.lastname: Keshavarz
authors.forename: Rashid
authors.initials: R
authors.lastname: Badri
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002563:Cerium / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D057930:Click Chemistry; D009566:Nitrates / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry*; D019810:Sodium Azide / Q000737:chemistry*; D020058:Styrene / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D009566:Nitrates; D016877:Oxidants; D014230:Triazoles; C532772:cerium(IV) ammonium nitrate; D002563:Cerium; D020058:Styrene; D019810:Sodium Azide