title: Dynamic combinatorial development of a neutral synthetic receptor that binds sulfate with nanomolar affinity in aqueous solution.
abstract: Using dynamic combinatorial disulfide chemistry we have developed a new generation of neutral synthetic receptors for anions, based on a macrobicyclic peptide structure. These receptors show an exceptional affinity and selectivity for sulfate ions in aqueous solution [log K(a) = 8.67 in 41 mol% (67 volume%) acetonitrile in water]. The high affinity depends on a delicate balance between rigidity and flexibility in the structure of the receptor.
authors.affiliation: Department of Chemistry, University of Cambridge, Cambridge, UK.
authors.forename: Zaida
authors.initials: Z
authors.lastname: Rodriguez-Docampo
authors.forename: Eugenia
authors.initials: E
authors.lastname: Eugenieva-Ilieva
authors.forename: Carsten
authors.initials: C
authors.lastname: Reyheller
authors.forename: Ana M
authors.initials: AM
authors.lastname: Belenguer
authors.forename: Stefan
authors.initials: S
authors.lastname: Kubik
authors.forename: Sijbren
authors.initials: S
authors.lastname: Otto
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D010456:Peptides, Cyclic / Q000737:chemistry; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry*; D012996:Solutions; D013431:Sulfates / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D010456:Peptides, Cyclic; D057786:Peptidomimetics; D012996:Solutions; D013431:Sulfates; D014867:Water