title: A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval.
abstract: OBJECTIVE
  To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval.
  
  
  METHODS
  Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effect-site concentration of 1.5 μg/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site concentration of either 1.5 (group I, n = 23), 2 (group II, n = 23) or 2.5 ng/mL (group III, n = 23). Hemodynamic variables, sedation, pain, the Aldrete recovery score, and side effects were recorded.
  
  
  RESULTS
  Hemodynamic variables, sedation and pain scores and the number of patients with the maximum Aldrete recovery score 10 min after the procedure were comparable among the groups. The number of patients in group III with the maximum Aldrete recovery score 5 min after the procedure was significantly lower than that in groups I and II. One patient in group II and one patient in group III suffered from nausea.
  
  
  CONCLUSIONS
  Similar pain-free conscious sedation conditions without significant changes in hemodynamic parameters were provided by all three protocols. However, target controlled infusion of remifentanil at 1.5 or 2 ng/mL proved superior at providing early recovery compared to 2.5 ng/mL.
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey. dcoskun@gazi.edu.tr
authors.forename: Demet
authors.initials: D
authors.lastname: Coskun
authors.forename: Berrin
authors.initials: B
authors.lastname: Gunaydin
authors.forename: Ayca
authors.initials: A
authors.lastname: Tas
authors.forename: Gozde
authors.initials: G
authors.lastname: Inan
authors.forename: Hulya
authors.initials: H
authors.lastname: Celebi
authors.forename: Kadir
authors.initials: K
authors.lastname: Kaya
mesh_terms: D000328:Adult; D000762:Anesthesia Recovery Period; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D054315:Oocyte Retrieval / Q000379:methods*; D010149:Postoperative Pain; D010880:Piperidines / Q000008:administration & dosage* / Q000009:adverse effects; D020250:Postoperative Nausea and Vomiting; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D000077208:Remifentanil
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol