title: e-PKGene: a knowledge-based research tool for analysing the impact of genetics on drug exposure.
abstract: e-PKGene (www.pharmacogeneticsinfo.org) is a manually curated knowledge product developed in the Department of Pharmaceutics at the University of Washington, USA. The tool integrates information from the literature, public repositories, reference textbooks, product prescribing labels and clinical review sections of new drug approval packages. The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information. The database helps scientists to mine pharmacokinetic and pharmacodynamic information for drug-metabolising enzymes and transporters, and provides access to available quantitative information on drug exposure contained in the literature. It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites. This review gives a brief description of the database organisation, its search functionalities and examples of use.
authors.affiliation: Department of Pharmaceutics, University of Washington, Seattle, USA.
authors.forename: Houda
authors.initials: H
authors.lastname: Hachad
authors.forename: Casey Lynnette
authors.initials: CL
authors.lastname: Overby
authors.forename: Sophie
authors.initials: S
authors.lastname: Argon
authors.forename: Catherine K
authors.initials: CK
authors.lastname: Yeung
authors.forename: Isabelle
authors.initials: I
authors.lastname: Ragueneau-Majlessi
authors.forename: René H
authors.initials: RH
authors.lastname: Levy
mesh_terms: D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D016208:Databases, Factual; D004347:Drug Interactions / Q000235:genetics; D064420:Drug-Related Side Effects and Adverse Reactions; D014644:Genetic Variation; D006801:Humans; D020407:Internet; D051188:Knowledge Bases; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D010599:Pharmacokinetics; D010600:Pharmacology; D012984:Software; D014584:User-Computer Interface
chemical_list: D002352:Carrier Proteins; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System