title: [Case-control study on the effect of ulinastatin on postoperative complications in elderly patients undergoing hip joint replacement].
abstract: OBJECTIVE
  To evaluate the preventive effects of ulinastatin (Uti) on postoperative complications in elderly patients undergoing hip joint replacement.
  
  
  METHODS
  From Angust 2009 to June 2010, 160 elderly patients undergoing selective hip joint replacement with ASA I to II were assessed according to American Society of Anesthesiologists classification, including 81 males and 79 females ranging in age from 65 to 83 years (mean 73.9 years). All the patients were divided into 2 groups according to random number table (80 patients in each group): control group (group C) and ulinastatin group (group U). The patients in Group U received intravenous injection of ulinastatin with a dose of 10,000 U/kg before skin incision,and then with dose of 5000 U/kg respectively at 1, 2 and 3 days after operatio. The patients in Group C received the same volume of normal saline instead of ulinastatin. Blood samples were taken preoperatively,at the end of surgery and 1, 2, 3 days after operation for determination of ALT, AST, Scr, BUN and Plasma D-dimer. Deep vein thrombosis and postoperative cognitive dysfunction (POCD) were also examined through color Doppler ultrasonography and neuroeognirive assessment on the postoperative 3 days respectively.
  
  
  RESULTS
  Compared with the preoperative values, the contents of ALT, AST, Scr, BUN and plasma D-dimer in each group all increased. Compared with group C,the values of ALT, AST, Scr, BUN and plasma D-dimer decreased markedly (P < 0.05). The incidence rate of DVT and POCD was 0 and 3.75% in group U, which were lower than those of patients in the group C (40%, 27.5%) respectively.
  
  
  CONCLUSIONS
  Intravenous infusion of ulinastatin during operation can protect important organ function, correct blood hypercoagulability, lower the occurrence of DVT and POCD, and prevent the postoperative complications in some degree.
authors.affiliation: Department of Anesthesiology, Ningbo No. 6 Hospital, Zhejiang, China. geyeying59198@163.com
authors.forename: Ye-ying
authors.initials: YY
authors.lastname: Ge
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
authors.forename: Jian-qing
authors.initials: JQ
authors.lastname: Cheng
authors.forename: Jian-ming
authors.initials: JM
authors.lastname: Chen
authors.forename: Rong-ming
authors.initials: RM
authors.lastname: Xu
authors.forename: Yan-di
authors.initials: YD
authors.lastname: Jiang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001806:Blood Urea Nitrogen; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000517:prevention & control; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006023:Glycoproteins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D014361:Trypsin Inhibitors / Q000627:therapeutic use*; D020246:Venous Thrombosis / Q000517:prevention & control
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D006023:Glycoproteins; D014361:Trypsin Inhibitors; C036309:fibrin fragment D; C028665:urinastatin