title: The second Phytophthora mating hormone defines interspecies biosynthetic crosstalk.
abstract: The heterothallic species of the agricultural pest Phytophthora use mating hormones α1 and α2 to regulate their sexual reproduction. Here we describe the absolute stereostructure of the second mating hormone α2 as defined by spectroscopic analysis and total synthesis. We have uncovered not only the interspecies universality of α hormones but also the pathway by which α2 is biosynthesized from phytol by A2-mating type strains and metabolized to α1 by A1 strains.
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. ojika@agr.nagoya-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Ojika
authors.forename: Shylaja D
authors.initials: SD
authors.lastname: Molli
authors.forename: Harumi
authors.initials: H
authors.lastname: Kanazawa
authors.forename: Arata
authors.initials: A
authors.lastname: Yajima
authors.forename: Kou
authors.initials: K
authors.lastname: Toda
authors.forename: Tomoo
authors.initials: T
authors.lastname: Nukada
authors.forename: Haimeng
authors.initials: H
authors.lastname: Mao
authors.forename: Ryo
authors.initials: R
authors.lastname: Murata
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Asano
authors.forename: Jianhua
authors.initials: J
authors.lastname: Qi
authors.forename: Youji
authors.initials: Y
authors.lastname: Sakagami
mesh_terms: D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism; D010838:Phytophthora / Q000378:metabolism*
chemical_list: D004224:Diterpenes; C504077:mating hormone alpha1, Phytophthora; C561798:mating hormone alpha2, Phytophthora