title: Factors predicting persistent thrombocytopenia after living donor liver transplantation in pediatric patients.
abstract: Thrombocytopenia is common after LT for pediatric end-stage liver diseases. Seventy-six pediatric patients (≤15 yr old) who underwent LDLT were evaluated for the incidence and predictive factors of post-transplant thrombocytopenia (PLT <100, 000/mm(3) ). The prevalence of thrombocytopenia at two wk and at 12 months post-transplant was 22/76 (28.9%) and 11/62 (17.7%), respectively. Thrombocytopenia at two wk after LDLT was significantly associated with age at transplant, preoperative PLT, GRWR, acute rejection, and CMV infection in univariate analysis. Moreover, preoperative PLT, GRWR, and acute rejection had a strong correlation in multivariate analysis. Thrombocytopenia at 12 months after LDLT was associated only with preoperative PLT. We also demonstrated that vascular complications caused thrombocytopenia and that successful treatment recovered the PLT. These results showed that, in addition to considering the preoperative PLT, post-operative monitoring of platelets is very helpful for the early detection of adverse events related to the graft liver in pediatric liver transplant patients.
authors.affiliation: Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Honda
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Shintaro
authors.initials: S
authors.lastname: Hayashida
authors.forename: Hiroko
authors.initials: H
authors.lastname: Suda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ohya
authors.forename: Kwang-Jong
authors.initials: KJ
authors.lastname: Lee
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takeichi
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Asonuma
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Inomata
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D058625:End Stage Liver Disease / Q000628:therapy; D005260:Female; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods*; D008297:Male; D015999:Multivariate Analysis; D010372:Pediatrics / Q000379:methods; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000209:etiology*; D013997:Time Factors