title: [Study on processing technology and processing principles of atractrylodis macrocephalae rhizoma].
abstract: OBJECTIVE
  To investigate the rule about changes on main active compositions of Atractrylodis Macrocephalae Rhizoma before and after being processed, and to explore its processing principle.
  
  
  METHODS
  The HPLC method was employed to determine the content of atractrylone, atractrylode I, II, III and total volatile oil of Atractrylodis Macrocephalae Rhizoma with different processes. The processing principle before and after processing of Atractrylodis Macrocephalae Rhizoma was investigated.
  
  
  RESULTS
  Compared with Atractrylodis Macrocephalae Rhizoma, the contents of atractrylone in different processed products of Atractrylodis Macrocephalae Rhizoma were decreased by some extent. The lowest content was 0.33% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt, reduced by 25.4%; the content of atractylenolide I, III were significantly increased, the highest content were 0.069% and 0.078% in Atractrylodis Macrocephalae Rhizoma of stir-fried with bran, respectively; the content of atractylenolide II was increased slightly, the highest content was 0.066% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt; the content of total volatile oil was significantly reduced, the lowest content was 0.64% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt.
  
  
  CONCLUSIONS
  The content of atractylon is significantly reduced after processing, which changed into atractrylode I, II, III by some extent, and improve the effective cure of Atractrylodis Macrocephala Rhizoma.
authors.affiliation: Pharmaceutical Department, Guangdong Provcial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China. 13688879998@163.com
authors.forename: Suihar
authors.initials: S
authors.lastname: Rong
authors.forename: Hai
authors.initials: H
authors.lastname: Lin
authors.forename: Ni
authors.initials: N
authors.lastname: Gao
mesh_terms: D031174:Atractylodes / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007783:Lactones / Q000032:analysis*; D009822:Oils, Volatile / Q000032:analysis; D027343:Rhizome / Q000737:chemistry*; D012717:Sesquiterpenes / Q000032:analysis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004365:Drugs, Chinese Herbal; D007783:Lactones; D009822:Oils, Volatile; D012717:Sesquiterpenes; C424804:atractylenolide I; C458582:atractylenolide II; C424802:atractylenolide III; C046196:atractylon