title: Risk factors for incident osteoarthritis of the hip and knee.
abstract: This article reviews the published risk factors associated with incident osteoarthritis of the lower extremity weight-bearing joints. Systemic risk factors include factors such as age, ethnicity, gender and genetic variables. Local risk factors are variables such as obesity, previous knee injury and occupational activities. Challenges in the study of incident osteoarthritis, and promising potential future study directions are also reviewed.
authors.affiliation: Division of Rheumatology, University of California, San Francisco, USA, chaganti@medicine.ucsf.edu.
authors.forename: R Krishna
authors.initials: RK
authors.lastname: Chaganti
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Lane