title: Quercetin has a protective role on histopathological findings on testicular ischaemia-reperfusion injury in rats.
abstract: We investigated the effects of quercetin on pathological findings on testicular ischaemia-reperfusion (I/R) injury in rats. Twenty-four male Wistar albino rats were randomly assigned into four groups: Group 1, control (n = 5); Group 2, sham (n = 4); Group 3, I/R (n = 8); and Group 4, I/R + quercetin (n = 7). Bilateral testicular artery and vein were occluded for 1 h, followed by reperfusion in I/R and I/R + quercetin animals. Quercetin (20 mg kg(-1) per day) was administrated once daily by gavage to Group 1 and Group 4, respectively, after reperfusion. At the end of the study, bilateral orchiectomies were performed for histopathologic examination. The tissue damage was evaluated with light microscopy. Normal inter-stitium and seminiferous tubules were observed in control group. In the sham group, rats were seen minimal oedema around the seminiferous tubules and congested vascular structures. In Group 3, oedema, vascular congestion and haemorrhage between seminiferous tubules were observed. In Group 4, histopathologic features were markedly less than Group 3 (P = 0.03). Our study demonstrated that quercetin seems to have a protective effect on testis histopathology in rats with testicular I/R.
authors.affiliation: Department of 2nd Urology, Atatürk Training and Research Hospital, Ankara, Turkey. drmaldemir@mynet.com
authors.forename: M
authors.initials: M
authors.lastname: Aldemir
authors.forename: G
authors.initials: G
authors.lastname: Özgün
authors.forename: E
authors.initials: E
authors.lastname: Önen
authors.forename: E
authors.initials: E
authors.lastname: Okulu
authors.forename: Ö
authors.initials: Ö
authors.lastname: Kayıgil
mesh_terms: D000818:Animals; D008297:Male; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*; D013737:Testis / Q000098:blood supply*
chemical_list: D011794:Quercetin