title: Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review.
abstract: BACKGROUND
  Hepatic follicular dendritic cell (FDC) sarcoma is an extremely rare neoplasm. Most commonly, FDC sarcoma presents as a solitary mass in lymph nodes, however, several extra-nodal locations have been identified.
  
  
  METHODS
  We report a case of a 53-year-old female who presented with symptoms of abdominal pain, fever, anemia, and jaundice. After an extensive review of the literature, we have found only 12 cases of hepatic FDC sarcoma.
  
  
  RESULTS
  The tumor was 11.5 cm in diameter and composed of spindle and epithelioid cells with ovoid nuclei and associated with mixed inflammatory infiltrate. Immunohistochemical stains were positive for CD35 and CD21. The patient underwent a left hepatic lobectomy.
  
  
  CONCLUSIONS
  Liver follicular dendritic cell sarcoma is a very rare tumor. Most cases present with abdominal pain and weight loss, and most of them can be managed by hepatic resection with excellent short-term outcomes.
authors.affiliation: Department of Surgery, Division of Hepatobiliary Surgery and Transplantation, New York Medical College, Westchester Medical Center, 95 Grassland Road, Valhalla, NY 10595, USA. martinsp@wcmc.com
authors.forename: Paulo N
authors.initials: PN
authors.lastname: Martins
authors.forename: Sanjay
authors.initials: S
authors.lastname: Reddy
authors.forename: Ann-Britt
authors.initials: AB
authors.lastname: Martins
authors.forename: Marcelo
authors.initials: M
authors.lastname: Facciuto
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D054740:Dendritic Cell Sarcoma, Follicular / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000601:surgery; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D017463:Receptors, Complement 3b / Q000032:analysis; D017464:Receptors, Complement 3d / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; C509991:CR1 protein, human; D017463:Receptors, Complement 3b; D017464:Receptors, Complement 3d