title: Activity of DBXX granules on anti-gastric ulcer and decreasing the side effect of chemotherapy in S180 tumor-bearing mice.
abstract: BACKGROUND
  DBXX is a derived prescription from "Banxiaxiexin Tang" in "Shanghan Lun", the representative prescription to regulate spleen and stomach.
  
  
  OBJECTIVE
  To determine the pharmacodynamics effects of DBXX granules on anti-ulcer and anti-side effect on digestive system induced by chemotherapeutic drugs.
  
  
  METHODS
  Chronic gastric ulcer was induced by an injection of 100% glacial acetic acid into the submucosal layer of the glandular stomach, then the area of all ulcers was added together as the ulcer index and inhibition rate of ulcer was calculated. While S180 tumor-bearing mice were treated with cyclophosphamide as the chemotherapeutic drug, the weight of food-intake after chemotherapy, the loss body weight, tumor weight and spleen index were weighed and calculated.
  
  
  RESULTS
  In the gastric ulcer bearing mice, DBXX granules showed a dose-dependent reduction of ulcer at the dose 4.87 and 9.73 g/kg. In the S180 tumor-bearing mice, low dose of DBXX granules could significantly improve every investigated index compared with that of control group (p < 0.05).
  
  
  CONCLUSIONS
  It proved that DBXX granules showed good healing effect on the chronic gastric ulcer mice and significant effect on decreasing the side effect of chemotherapy of S180 tumor-bearing mice.
authors.affiliation: Department of Pharmacognosy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xue
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Cao
authors.forename: Na
authors.initials: N
authors.lastname: Han
authors.forename: Xiaowan
authors.initials: X
authors.lastname: Lin
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
mesh_terms: D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000633:toxicity*; D003520:Cyclophosphamide / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D013154:Spleen / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D047368:Tumor Burden / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000897:Anti-Ulcer Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; C477181:banxiaxiexintang decoction; D003520:Cyclophosphamide; D019342:Acetic Acid