title: A potential role for monoclonal antibodies in prophylactic and therapeutic treatment of influenza.
abstract: The role of humoral response in the effective control of infection by influenza viruses is well known, but the protection is usually limited to the infecting or vaccinating isolate and to few related strains. Recent studies have evidenced the existence of B-cell epitopes broadly conserved among different influenza subtypes recognized by monoclonal antibodies endowed with unprecedented broad activity. In this review, all major monoclonal antibodies directed against different influenza virus proteins are reported and their potential in the design of new anti-influenza prophylactic or therapeutic strategies is discussed.
authors.affiliation: Laboratorio di Microbiologia e Virologia, Università "Vita-Salute" San Raffaele, Milano, Italy. mancini.nicasio@hsr.it
authors.forename: Nicasio
authors.initials: N
authors.lastname: Mancini
authors.forename: Laura
authors.initials: L
authors.lastname: Solforosi
authors.forename: Nicola
authors.initials: N
authors.lastname: Clementi
authors.forename: Donata
authors.initials: D
authors.lastname: De Marco
authors.forename: Massimo
authors.initials: M
authors.lastname: Clementi
authors.forename: Roberto
authors.initials: R
authors.lastname: Burioni
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects* / Q000235:genetics / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology / Q000627:therapeutic use; D007251:Influenza, Human / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D007252:Influenza Vaccines; D014764:Viral Proteins