title: Does metoclopramide impair anastomotic healing of the left colon of rats?
abstract: OBJECTIVE
  To evaluate the effects of metoclopramide on the formation of adhesion and the healing of left colonic anastomoses in rats.
  
  
  METHODS
  Forty rats underwent sectioning of the left colon and end-to-end anastomosis and were divided into two groups of 20 animals for the administration of metoclopramide (experimental group - E) or saline solution (control group - C). Each group was divided into subgroups of 10 animals each to be killed on the third (E3 and C3) or seventh postoperative day (E7 and C7). Adhesion was assessed, and a colonic segment containing the anastomosis was removed for analysis of breaking strength and hydroxyproline concentration.
  
  
  RESULTS
  There were no deaths or dehiscence on the 3(rd) postoperative day. There was one death and one blocked anastomotic dehiscence in the E7 group. No significant differences between groups were found in the analysis of clinical outcome, intra-cavity adhesion, adhesion to the anastomosis or breaking strength on the 3(rd) and 7(th) postoperative day. Hydroxyproline concentration was higher in the control group on the 3(rd) (p=0.006) but not on the 7(th) postoperative day (p=0.241).
  
  
  CONCLUSIONS
  Metoclopramide did not have harmful effects on the healing of intestinal anastomoses in rats.
authors.affiliation: Postgraduate Program in Medical Sciences, School of Medicine, UnB, Brasilia, DF, Brazil.
authors.forename: Silvana Marques e
authors.initials: SM
authors.lastname: Silva
authors.forename: Vânia Maria Moraes
authors.initials: VM
authors.lastname: Ferreira
authors.forename: Omar
authors.initials: O
authors.lastname: Feres
authors.forename: Paulo Gonçalves de
authors.initials: PG
authors.lastname: Oliveira
authors.forename: João Batista de
authors.initials: JB
authors.lastname: Sousa
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000601:surgery*; D018492:Dopamine Antagonists / Q000009:adverse effects*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects*; D011184:Postoperative Period; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013718:Tensile Strength; D013997:Time Factors; D000267:Tissue Adhesions; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D018492:Dopamine Antagonists; D008787:Metoclopramide; D006909:Hydroxyproline