title: Rare case of Takayasu's arteritis associated with Crohn's disease.
abstract: Takayasu's arteritis (TA) and Crohn's disease (CD) are chronic inflammatory diseases of uncertain etiology. Although co-existence of these rare diseases is estimated to occur in 1 in 10 billion individuals, a theoretically unexpected association has been reported in several patients and it is suggested that those associations may have been more than an unusual coincidence. Herein, we report a case of TA associated with clinically inactive CD. A Japanese woman was diagnosed with colonic CD at the age of 15, developed aortic valve regurgitation at 19, and then presented with general fatigue, low grade fever, and painful sensations in her left arm at 25. She was diagnosed with TA based on computed tomography scanning and magnetic resonance angiography findings, and treatments with prednisolone and cyclosporine were started. Thereafter, valve replacement and right coronary artery bypass graft surgery were performed. The possible pathophysiological mechanism responsible for concurrent existence of TA and CD may be associated with immune disorders. Early diagnosis of vascular lesions for patients with inflammatory bowel disease is highly encouraged.
authors.affiliation: Department of Internal Medicine II, Shimane University School of Medicine, Japan.
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Kusunoki
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
authors.forename: Mariko
authors.initials: M
authors.lastname: Sato
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Sumita
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mishima
authors.forename: Mayumi
authors.initials: M
authors.lastname: Okada
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Tada
authors.forename: Akihiko
authors.initials: A
authors.lastname: Oka
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Fukuba
authors.forename: Naoki
authors.initials: N
authors.lastname: Oshima
authors.forename: Ichiro
authors.initials: I
authors.lastname: Moriyama
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yuki
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sato
authors.forename: Yuji
authors.initials: Y
authors.lastname: Amano
authors.forename: Yohko
authors.initials: Y
authors.lastname: Murakawa
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000293:Adolescent; D000328:Adult; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery; D001241:Aspirin / Q000008:administration & dosage; D001026:Coronary Artery Bypass; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis; D016572:Cyclosporine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D018810:Magnetic Resonance Angiography; D011239:Prednisolone / Q000008:administration & dosage; D013625:Takayasu Arteritis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014859:Warfarin / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D014859:Warfarin; D016572:Cyclosporine; D011239:Prednisolone; D001241:Aspirin