title: The role of apolipoprotein E in bone metabolism.
abstract: Apolipoprotein E (apoE) is a major structural apolipoprotein of several lipoprotein classes. Over the last 13 years, numerous studies have focused on the question whether human apoE affects bone phenotypes and, more recently, whether apoE regulates bone metabolism in mice. Here, we first provide a brief background introduction into the structure, established physiological and pathophysiological functions of apoE, and will then discuss the new aspects of the emerging role of apoE in bone.
authors.affiliation: Department of Orthopaedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. niemeier@uke.uni-hamburg.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Niemeier
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schinke
authors.forename: Joerg
authors.initials: J
authors.lastname: Heeren
authors.forename: Michael
authors.initials: M
authors.lastname: Amling
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D015519:Bone Density / Q000235:genetics; D001842:Bone and Bones / Q000378:metabolism*; D050723:Fractures, Bone / Q000150:complications / Q000208:ethnology / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism
chemical_list: D001057:Apolipoproteins E; D020033:Protein Isoforms