title: Is it time to recast the principles of antimicrobial prophylaxis?
abstract: Perioperative antimicrobial prophylaxis has been a time-honored principle in the prevention of surgical site infection. Its effectiveness has recently been questioned. Potential reasons for the lack of demonstrable efficacy and suggestions for re-examination of this concept are presented.
authors.affiliation: American Board of Surgery, 1617 John F, Kennedy Blvd,, Suite 860, Philadelphia, PA, 19103-1847, USA. mmalangoni@absurgery.org.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Malangoni