title: Molecular signaling in pathogenesis of craniosynostosis: the role of fibroblast growth factor and transforming growth factor-β.
abstract: The interplay of signals between dura mater, suture mesenchyme, and brain is essential in determining the fate of cranial sutures and the pathogenesis of premature suture fusion leading to craniosynostosis. At the forefront of research into suture fusion is the role of fibroblast growth factor and transforming growth factor-β, which have been found to be critical in the cell-signaling cascade involved in aberrant suture fusion. In this review, the authors discuss recent and ongoing research into the role of fibroblast growth factor and transforming growth factor-β in the etiopathogenesis of craniosynostosis.
authors.affiliation: Department of Plastic Surgery, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Harvey
authors.initials: H
authors.lastname: Chim
authors.forename: Sunil
authors.initials: S
authors.lastname: Manjila
authors.forename: Alan R
authors.initials: AR
authors.lastname: Cohen
authors.forename: Arun K
authors.initials: AK
authors.lastname: Gosain
mesh_terms: D000818:Animals; D003398:Craniosynostoses / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology*
chemical_list: D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors