title: [The reaction of the neuroblastoma cells in the culture on the influence of tretionine and neurotoxine].
abstract: Effect of the tretionine (retinoid) and aluminum chloride (neurotoxin) on the growth and differentiation of neuroblastoma cells in culture after their introduction into the medium separately and in combination was studied. The introduction of these substances creates a new information field in the medium, which becomes apparent by the reactions of neuroblastoma found on the populational and cellular levels of its organization. The presence of tretionine stimulates proliferation and induces differentiation of the cells into astrocytes. Aluminum chloride inhibits cell proliferation and enhances the process of their destruction in the monolayer. The variety of the reactions of neuroblastoma cells to the presence of these substances in the medium indicates the existence and functioning of a mechanism that selects from the information introduced only the portion which may contribute to adaptation of neuroblastoma cells to the changed culture conditions.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Magakian
authors.forename: Z A
authors.initials: ZA
authors.lastname: Karalian
authors.forename: E M
authors.initials: EM
authors.lastname: Karalova
authors.forename: L O
authors.initials: LO
authors.lastname: Abroian
authors.forename: L A
authors.initials: LA
authors.lastname: Akopian
authors.forename: A C
authors.initials: AC
authors.lastname: Avetisian
authors.forename: Z B
authors.initials: ZB
authors.lastname: Semerdzhian
mesh_terms: D000222:Adaptation, Physiological; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology*; D004247:DNA / Q000032:analysis; D007257:Information Theory; D009447:Neuroblastoma; D046569:Neuroepithelial Cells / Q000187:drug effects* / Q000473:pathology; D009498:Neurotoxins / Q000494:pharmacology*; D012313:RNA / Q000032:analysis; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D017607:Aluminum Compounds; D000970:Antineoplastic Agents; D002712:Chlorides; D009498:Neurotoxins; D000077410:Aluminum Chloride; D014212:Tretinoin; D012313:RNA; D004247:DNA