title: Anaerobicizing into pluripotency.
abstract: Reprogramming involves multiple layers of molecular regulation, yet it remains relatively unknown how the cell's metabolism is changing and/or contributing to this process. In this issue of Cell Metabolism, Folmes et al. (2011) demonstrate that reprogramming induces a bioenergetic transition from an oxidative to a glycolytic state, and provide evidence to suggest that these changes may precede pluripotency.
authors.affiliation: Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: Athanasia D
authors.initials: AD
authors.lastname: Panopoulos
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Izpisua Belmonte