title: Therapeutic effects of cinnamaldehyde and potentiation of its efficacy in combination with methylcellulose on murine oral candidiasis.
abstract: We examined the therapeutic effects of cinnamaldehyde and the potentiation of those effects with cassia and cinnamaldehyde when combined with the food additive methylcellulose against murine oral candidiasis. When 19.5mg/ml of cinnamaldehyde was administered in the oral cavity of Candida infected mice, the oral symptoms were improved. Furthermore, when either a cassia or a cinnamaldehyde preparation in combination with methylcellulose was administered to oral candidiasis-inflicted mice, the therapeutic effects of cassia or cinnamaldehyde potentiated. Methylcellulose itself did not affect the oral symptoms or the viable number of C. albicans cells. GC/MS analysis showed that the dose of cinnamaldehyde remaining in the tongue tissue of mice treated with the cinnamaldehyde-methylcellulose mixture was higher than that in mice administered cinnamaldehyde alone, and also showed that cinnamaldehyde was not detected in the blood of any of the tested mice. These findings suggested that the combination of cassia or cinnamaldehyde and methylcellulose may be a useful prophylactic or therapeutic tool against oral candidiasis.
authors.affiliation: Research and Product Development Division, S&B Foods Inc.,Tokyo, Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Taguchi
authors.forename: Kazumi
authors.initials: K
authors.lastname: Hayama
authors.forename: Masashi
authors.initials: M
authors.lastname: Okada
authors.forename: Takehito
authors.initials: T
authors.lastname: Sagawa
authors.forename: Ryo
authors.initials: R
authors.lastname: Arai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Abe
mesh_terms: D000171:Acrolein / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000284:Administration, Oral; D000818:Animals; D002180:Candidiasis, Oral / Q000188:drug therapy*; D002366:Cassia; D004195:Disease Models, Animal; D004357:Drug Synergism; D005260:Female; D008747:Methylcellulose / Q000008:administration & dosage*; D051379:Mice; D008813:Mice, Inbred ICR; D028321:Plant Preparations / Q000008:administration & dosage
chemical_list: D028321:Plant Preparations; D000171:Acrolein; D008747:Methylcellulose; C012843:cinnamaldehyde