title: ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia.
abstract: ROR1 is a receptor tyrosine kinase expressed during embryogenesis, on chronic lymphocytic leukemia (CLL) and in other malignancies. Hematogones (non-neoplastic B-lymphocyte precursors) express surface ROR1 at an intermediate stage of maturation that lacks CD34 or TdT. The neoplastic counterpart to hematogones is precursor-B acute lymphoblastic leukemia (B-ALL), but less than 10% of B-ALL express surface ROR1, and these ROR1+ B-ALL cases have an unusually high frequency of lacking CD34 and/or having t(1;19), a chromosomal translocation that defines a specific subtype of B-ALL.
authors.affiliation: Department of Pathology, Moores Cancer Center, University of California San Diego, 3855 Health Drive, La Jolla, CA 92093-0987, USA. ebroome@ucsd.edu
authors.forename: H Elizabeth
authors.initials: HE
authors.lastname: Broome
authors.forename: Laura Z
authors.initials: LZ
authors.lastname: Rassenti
authors.forename: Huan-You
authors.initials: HY
authors.lastname: Wang
authors.forename: Lilly M
authors.initials: LM
authors.lastname: Meyer
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Kipps
mesh_terms: D015703:Antigens, CD / Q000032:analysis / Q000096:biosynthesis; D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D005434:Flow Cytometry; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D054448:Precursor Cells, B-Lymphoid / Q000378:metabolism* / Q000473:pathology; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000235:genetics / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: D015703:Antigens, CD; C078716:ROR1 protein, human; D057050:Receptor Tyrosine Kinase-like Orphan Receptors