title: Does sustained weight loss reverse the metabolic syndrome?
abstract: The prevalence of the metabolic syndrome (MetS) has increased rapidly in North America in recent years. Presently, the MetS is found in 34.3% of the population, and the prevalence is likely to continue to increase in parallel with the obesity epidemic. Losing weight and long-term maintenance of the weight loss are primary targets to beneficially reverse all of the components of the MetS. This paper reviews the clinical and experimental evidence for the reversal of the metabolic complications related to the MetS that follows a sustained weight loss.
authors.affiliation: Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Anschutz Medical Center, 12801 E. 17th Avenue, Aurora, CO 80045, USA.
authors.forename: Annie
authors.initials: A
authors.lastname: Ferland
authors.forename: Robert H
authors.initials: RH
authors.lastname: Eckel
mesh_terms: D019440:Anti-Obesity Agents / Q000627:therapeutic use; D050110:Bariatric Surgery; D018450:Disease Progression; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control; D006949:Hyperlipidemias / Q000517:prevention & control; D006973:Hypertension / Q000517:prevention & control*; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D056128:Obesity, Abdominal / Q000150:complications / Q000473:pathology / Q000517:prevention & control*; D040242:Risk Reduction Behavior; D013997:Time Factors; D015431:Weight Loss
chemical_list: D019440:Anti-Obesity Agents