title: MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: a Children's Oncology Group (COG) study.
abstract: BACKGROUND
  Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements.
  
  
  METHODS
  Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age.
  
  
  RESULTS
  Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases.
  
  
  CONCLUSIONS
  These patterns may provide important etiological insight into the biology of infant leukemia.
authors.affiliation: University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota.
authors.forename: Thien N
authors.initials: TN
authors.lastname: Sam
authors.forename: John H
authors.initials: JH
authors.lastname: Kersey
authors.forename: Amy M
authors.initials: AM
authors.lastname: Linabery
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Johnson
authors.forename: Nyla A
authors.initials: NA
authors.lastname: Heerema
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Hilden
authors.forename: Stella M
authors.initials: SM
authors.lastname: Davies
authors.forename: Gregory H
authors.initials: GH
authors.lastname: Reaman
authors.forename: Julie A
authors.initials: JA
authors.lastname: Ross
mesh_terms: D017677:Age Distribution; D017668:Age of Onset; D005260:Female; D015321:Gene Rearrangement; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053208:Kaplan-Meier Estimate; D007938:Leukemia / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D017678:Sex Distribution
chemical_list: C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase