title: Neonatal outcome after prenatal interventions for congenital lung lesions.
abstract: Congenital lung lesions, mostly congenital cystic adenomatoid malformations (CCAMs) and bronchopulmonary sequestrations (BPSs), are uncommon disorders. Prenatal intervention in severely affected (hydropic) fetuses has drastically improved perinatal survival. Not much is known, however, on the short-term and long-term respiratory and neurodevelopmental outcome. Several small case series have been reported and suggest an increased incidence of neonatal morbidity, mainly associated with prematurity and respiratory failure at birth. Overall, neonatal mortality and morbidity after prenatal interventions for CCAM seems to be worse than for BPS. This review focuses on the neonatal outcome after prenatal intervention for congenital lung lesions and summarizes the results reported in the literature.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands. r.witlox@lumc.nl
authors.forename: Ruben S
authors.initials: RS
authors.lastname: Witlox
authors.forename: Enrico
authors.initials: E
authors.lastname: Lopriore
authors.forename: Dick
authors.initials: D
authors.lastname: Oepkes
authors.forename: Frans J
authors.initials: FJ
authors.lastname: Walther
mesh_terms: D001998:Bronchopulmonary Sequestration / Q000150:complications / Q000628:therapy*; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000150:complications / Q000628:therapy*; D005260:Female; D046128:Fetal Therapies; D006801:Humans; D007231:Infant, Newborn; D009017:Morbidity; D011247:Pregnancy; D012131:Respiratory Insufficiency / Q000453:epidemiology / Q000209:etiology; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal