title: Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm.
abstract: Pilocarpine-induced status epilepticus (SE) results in chronic spontaneous recurrent seizures resembling human temporal lobe epilepsy. In this and other experimental models, behaviorally monitored seizure frequency was suggested to vary in a circadian fashion, and to increase with time. We re-addressed those hypotheses using continuous video-electroencephalography (EEG) telemetry in rats with SE at 30 days of age. In 11 chronically epileptic animals monitored up to 300 days after SE in a fixed 12 h light/dark cycle, we found that seizure frequency did not correlate with circadian rhythm.
authors.affiliation: Oscar Langendorff Institute of Physiology, University of Rostock, Rostock, Germany.
authors.forename: Rika
authors.initials: R
authors.lastname: Bajorat
authors.forename: Marleen
authors.initials: M
authors.lastname: Wilde
authors.forename: Tina
authors.initials: T
authors.lastname: Sellmann
authors.forename: Timo
authors.initials: T
authors.lastname: Kirschstein
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Köhling
mesh_terms: D000818:Animals; D016009:Chi-Square Distribution; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D004195:Disease Models, Animal; D004569:Electroencephalography; D008297:Male; D010862:Pilocarpine / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000209:etiology*; D013226:Status Epilepticus / Q000139:chemically induced / Q000150:complications*
chemical_list: D010862:Pilocarpine