title: No evidence that extended tracts of homozygosity are associated with Alzheimer's disease.
abstract: We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.
authors.affiliation: MRC Centre for Neuropyschiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Heath Park. simsrc@cardiff.ac.uk
authors.forename: Rebecca
authors.initials: R
authors.lastname: Sims
authors.forename: Sarah
authors.initials: S
authors.lastname: Dwyer
authors.forename: Denise
authors.initials: D
authors.lastname: Harold
authors.forename: Amy
authors.initials: A
authors.lastname: Gerrish
authors.forename: Paul
authors.initials: P
authors.lastname: Hollingworth
authors.forename: Jade
authors.initials: J
authors.lastname: Chapman
authors.forename: Nicola
authors.initials: N
authors.lastname: Jones
authors.forename: Richard
authors.initials: R
authors.lastname: Abraham
authors.forename: Dobril
authors.initials: D
authors.lastname: Ivanov
authors.forename: Jaspreet Singh
authors.initials: JS
authors.lastname: Pahwa
authors.forename: Valentina
authors.initials: V
authors.lastname: Moskvina
authors.forename: Kimberley
authors.initials: K
authors.lastname: Dowzell
authors.forename: Charlene
authors.initials: C
authors.lastname: Thomas
authors.forename: Alexandra
authors.initials: A
authors.lastname: Stretton
authors.forename: Simon
authors.initials: S
authors.lastname: Lovestone
authors.forename: John
authors.initials: J
authors.lastname: Powell
authors.forename: Petroula
authors.initials: P
authors.lastname: Proitsi
authors.forename: Michelle K
authors.initials: MK
authors.lastname: Lupton
authors.forename: Carol
authors.initials: C
authors.lastname: Brayne
authors.forename: David C
authors.initials: DC
authors.lastname: Rubinsztein
authors.forename: Michael
authors.initials: M
authors.lastname: Gill
authors.forename: Brian
authors.initials: B
authors.lastname: Lawlor
authors.forename: Aoibhinn
authors.initials: A
authors.lastname: Lynch
authors.forename: Kevin
authors.initials: K
authors.lastname: Morgan
authors.forename: Kristelle S
authors.initials: KS
authors.lastname: Brown
authors.forename: Peter A
authors.initials: PA
authors.lastname: Passmore
authors.forename: David
authors.initials: D
authors.lastname: Craig
authors.forename: Bernadette
authors.initials: B
authors.lastname: McGuiness
authors.forename: Stephen
authors.initials: S
authors.lastname: Todd
authors.forename: Janet A
authors.initials: JA
authors.lastname: Johnston
authors.forename: Clive
authors.initials: C
authors.lastname: Holmes
authors.forename: David
authors.initials: D
authors.lastname: Mann
authors.forename: A David
authors.initials: AD
authors.lastname: Smith
authors.forename: Seth
authors.initials: S
authors.lastname: Love
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Kehoe
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.forename: Simon
authors.initials: S
authors.lastname: Mead
authors.forename: Nick
authors.initials: N
authors.lastname: Fox
authors.forename: Martin
authors.initials: M
authors.lastname: Rossor
authors.forename: John
authors.initials: J
authors.lastname: Collinge
authors.forename: Gill
authors.initials: G
authors.lastname: Livingston
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Bass
authors.forename: Hugh
authors.initials: H
authors.lastname: Gurling
authors.forename: Andrew
authors.initials: A
authors.lastname: McQuillin
authors.forename: Lesley
authors.initials: L
authors.lastname: Jones
authors.forename: Peter A
authors.initials: PA
authors.lastname: Holmans
authors.forename: Michael
authors.initials: M
authors.lastname: O'Donovan
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.forename: Julie
authors.initials: J
authors.lastname: Williams
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005260:Female; D005796:Genes / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006720:Homozygote; D006801:Humans; D008297:Male