title: Relationships of thigh muscle contractile and non-contractile tissue with function, strength, and age in boys with Duchenne muscular dystrophy.
abstract: The purpose of this study was to assess the contractile and non-contractile content in thigh muscles of patients with Duchenne muscular dystrophy (DMD) and determine the relationship with functional abilities. Magnetic resonance images of the thigh were acquired in 28 boys with DMD and 10 unaffected boys. Muscle strength, timed functional tests, and the Brookes Lower Extremity scale were also assessed. Non-contractile content in the DMD group was significantly greater than in the control group for six muscles, including rectus femoris, biceps femoris-long head and adductor magnus. Non-contractile content in the total thigh musculature assessed by MRI correlated with the Brookes scale (r(s)=0.75) and supine-up test (r(s)=0.68), as well as other functional measures. An age-related specific torque increase was observed in the control group (r(s)=0.96), but not the DMD (r(s)=0.06). These findings demonstrate that MRI measures of contractile and non-contractile content can provide important information about disease progression in DMD.
authors.affiliation: Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA. akima@nagoya-u.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akima
authors.forename: Donovan
authors.initials: D
authors.lastname: Lott
authors.forename: Claudia
authors.initials: C
authors.lastname: Senesac
authors.forename: Jasjit
authors.initials: J
authors.lastname: Deol
authors.forename: Sean
authors.initials: S
authors.lastname: Germain
authors.forename: Ishu
authors.initials: I
authors.lastname: Arpan
authors.forename: Roxanna
authors.initials: R
authors.lastname: Bendixen
authors.forename: H
authors.initials: H
authors.lastname: Lee Sweeney
authors.forename: Glenn
authors.initials: G
authors.lastname: Walter
authors.forename: Krista
authors.initials: K
authors.lastname: Vandenborne
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D018450:Disease Progression; D006801:Humans; D035002:Lower Extremity / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D053580:Muscle Strength / Q000502:physiology*; D018482:Muscle, Skeletal / Q000503:physiopathology; D020388:Muscular Dystrophy, Duchenne / Q000175:diagnosis / Q000503:physiopathology*; D013848:Thigh / Q000503:physiopathology*; D019415:Torque