title: MicroRNAs might be promising biomarkers of human gliomas.
abstract: Recently, altered expression levels of several microRNAs have been observed in gliomas, the most frequent primary brain tumor in adults. To review whether microRNAs might be promising biomarkers of human gliomas, we comprehensively searched the Cochrane Library, Medline and EMbase from 1966 to 2010 with the language limitation of English. We found that further understanding of the functions of miRNAs in specific cellular events is needed; the continuous technological advances in accurate and cost-effective miRNAs detection provide the prospect of a very promising role for miRNAs as novel diagnostic biomarkers of gliomas.
authors.affiliation: Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Xianhou
authors.initials: X
authors.lastname: Yuan
authors.forename: Zhangming
authors.initials: Z
authors.lastname: Zhou
authors.forename: Juntao
authors.initials: J
authors.lastname: Hu
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Shengli
authors.initials: S
authors.lastname: Hu
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Xinjian
authors.initials: X
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis* / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D005910:Glioma / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000032:analysis* / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs