title: Applications of vectorized gold nanoparticles to the diagnosis and therapy of cancer.
abstract: This critical review focuses on the anti-cancer fight using gold nanoparticles (AuNPs) functionalized with chemotherapeutic drugs in so-called "complexes" (supramolecular assemblies) and "conjugates" (covalent assemblies) as vectors. There is a considerable body of recent literature on various tumor-imaging techniques using the surface plasmon band (SPB) and the "passive" and "active" vectorization of anti-cancer drugs. This article reviews the main concepts and the most recent literature data with emphasis on AuNP preparation, cytotoxicities and use in selective targeting of cancer cells with over-expressed receptors for diagnosis and therapy (108 references).
authors.affiliation: ENSCPB, Université Bordeaux 1, 33607 Pessac, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Llevot
authors.forename: Didier
authors.initials: D
authors.lastname: Astruc
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D050091:Dendrimers / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D020349:Surface Plasmon Resonance
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D004337:Drug Carriers; D011108:Polymers; D011092:Polyethylene Glycols; D006046:Gold