title: [Detection of large deletions of mitochondrial DNA in tissues of mice exposed to X-rays].
abstract: Large mtDNA deletions in mouse brain and spleen cells, induced by X-radiation at doses of 2 and 5 Gy were studied within four weeks after the exposure of animals to X-rays. Variations in the content of extracellular (deletion) mtDNA were examined in the blood plasma of mice irradiated with 5 Gy in the same postirradiation times. Ionizing radiation was shown to effectively induce large mtDNA deletions at the doses chosen. The level of deletion mtDNA was dependent on dose and postirradiation time.
authors.forename: V N
authors.initials: VN
authors.lastname: Antipova
authors.forename: L V
authors.initials: LV
authors.lastname: Malakhova
authors.forename: V G
authors.initials: VG
authors.lastname: Bezlepkin
mesh_terms: D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D004272:DNA, Mitochondrial / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009928:Organ Specificity / Q000528:radiation effects; D017384:Sequence Deletion / Q000528:radiation effects*; D013154:Spleen / Q000378:metabolism*; D014965:X-Rays / Q000009:adverse effects*
chemical_list: D004272:DNA, Mitochondrial