title: Pharmacogenomics of cisplatin-induced ototoxicity.
abstract: Cisplatin ototoxicity affects different individuals in a widely variable manner. These variations are likely to be explained by genetic differences among those affected. It would be highly advantageous to identify genetic variants that predispose to cisplatin ototoxicity in order to minimize the risk to susceptible subgroups. Although this area of research is very important, only a few studies have rigorously examined the genetic basis for cisplatin-induced susceptibility to hearing loss. This article addresses recent progress in clarifying the incidence of cisplatin ototoxicity and the risk factors and controversies regarding the identification of genetic variants associated with cisplatin-induced hearing loss.
authors.affiliation: Department of Surgery, Division of Otolaryngology, Southern Illinois University, School of Medicine, Springfield, IL, USA. dmukherjea@siumed.edu
authors.forename: Debashree
authors.initials: D
authors.lastname: Mukherjea
authors.forename: Leonard P
authors.initials: LP
authors.lastname: Rybak
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D034381:Hearing Loss / Q000139:chemically induced* / Q000235:genetics*; D006801:Humans; D026561:Low Density Lipoprotein Receptor-Related Protein-2 / Q000235:genetics* / Q000378:metabolism; D008780:Methyltransferases / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy; D010597:Pharmacogenetics; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D026561:Low Density Lipoprotein Receptor-Related Protein-2; D017382:Reactive Oxygen Species; D008780:Methyltransferases; D002394:Catechol O-Methyltransferase; C022745:thiopurine methyltransferase; D005982:Glutathione Transferase; D002945:Cisplatin