title: Amelioratory effect of Andrographis paniculata Nees on liver, kidney, heart, lung and spleen during nicotine induced oxidative stress.
abstract: The ameliorative properties of bioactive compound andrographolide (ANDRO), aqueous extract of Andrographis paniculata (AE-AP) and vitamin E (vit.E) were tested against nicotine induced liver, kidney, heart, lung and spleen toxicity. A group of male Wistar rats were intraperitoneally administered vehicle, nicotine (1mg/kg body weight/day), nicotine+ANDRO (250mg/kg body weight/day), nicotine+AE-AP (250mg/kg body weight/day) and nicotine+vit.E (50mg/kg body weight/day) for the period of 7 days. The significantly increased levels of lipid peroxidation, protein oxidation and the decreased antioxidant enzyme status were noted in nicotine treated group as compared to vehicle treated group. ANDRO, AE-AP and vit.E significantly reduced the lipid peroxidation, protein oxidation and increased the antioxidant enzyme status. This indicates A. paniculata and vit.E may act as putative protective agent against nicotine induced tissue injury and may pave a new path to develop suitable drug therapy.
authors.affiliation: Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore 721102, West Bengal, India.
authors.forename: Sreeparna
authors.initials: S
authors.lastname: Neogy
authors.forename: Subhasis
authors.initials: S
authors.lastname: Das
authors.forename: Santanu Kar
authors.initials: SK
authors.lastname: Mahapatra
authors.forename: Nirjal
authors.initials: N
authors.lastname: Mandal
authors.forename: Somenath
authors.initials: S
authors.lastname: Roy