title: Effects of acidosis and Fe (II) on lipid peroxidation in phospholipid extract: Comparative effect of diphenyl diselenide and ebselen.
abstract: The influence of acidosis on lipid peroxidation in phospholipids extract from egg yolk was studied. In addition, we have also tested the effect of pH on the anti-oxidant properties of diphenyl diselenide and ebselen. Acidosis increased rate of lipid peroxidation both in the absence and presence of Fe (II). Diphenyl diselenide significantly protected TBARS production at all studied pH values while ebselen offered only a small statistically non-significant protection. However, changing the pH of the reaction medium did not alter the anti-oxidant activity of the tested compounds. This study provides in vitro evidence for acidosis-induced oxidative stress in phospholipids extract and anti-oxidant action of diphenyl diselenide.
authors.affiliation: Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
authors.forename: Waseem
authors.initials: W
authors.lastname: Hassan
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ibrahim
authors.forename: Cristina W
authors.initials: CW
authors.lastname: Nogueira
authors.forename: Mushtaq
authors.initials: M
authors.lastname: Ahmed
authors.forename: Joao B T
authors.initials: JB
authors.lastname: Rocha