title: Two new complete genome sequences offer insight into host and tissue specificity of plant pathogenic Xanthomonas spp.
abstract: Xanthomonas is a large genus of bacteria that collectively cause disease on more than 300 plant species. The broad host range of the genus contrasts with stringent host and tissue specificity for individual species and pathovars. Whole-genome sequences of Xanthomonas campestris pv. raphani strain 756C and X. oryzae pv. oryzicola strain BLS256, pathogens that infect the mesophyll tissue of the leading models for plant biology, Arabidopsis thaliana and rice, respectively, were determined and provided insight into the genetic determinants of host and tissue specificity. Comparisons were made with genomes of closely related strains that infect the vascular tissue of the same hosts and across a larger collection of complete Xanthomonas genomes. The results suggest a model in which complex sets of adaptations at the level of gene content account for host specificity and subtler adaptations at the level of amino acid or noncoding regulatory nucleotide sequence determine tissue specificity.
authors.affiliation: Department of Plant Pathology, Iowa State University, 351 Bessey Hall, Iowa State University, Ames, IA 50011, USA. ajbog@iastate.edu
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Bogdanove
authors.forename: Ralf
authors.initials: R
authors.lastname: Koebnik
authors.forename: Hong
authors.initials: H
authors.lastname: Lu
authors.forename: Ayako
authors.initials: A
authors.lastname: Furutani
authors.forename: Samuel V
authors.initials: SV
authors.lastname: Angiuoli
authors.forename: Prabhu B
authors.initials: PB
authors.lastname: Patil
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Van Sluys
authors.forename: Robert P
authors.initials: RP
authors.lastname: Ryan
authors.forename: Damien F
authors.initials: DF
authors.lastname: Meyer
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Han
authors.forename: Gudlur
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authors.lastname: Aparna
authors.forename: Misha
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authors.lastname: Rajaram
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Delcher
authors.forename: Adam M
authors.initials: AM
authors.lastname: Phillippy
authors.forename: Daniela
authors.initials: D
authors.lastname: Puiu
authors.forename: Michael C
authors.initials: MC
authors.lastname: Schatz
authors.forename: Martin
authors.initials: M
authors.lastname: Shumway
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Sommer
authors.forename: Cole
authors.initials: C
authors.lastname: Trapnell
authors.forename: Faiza
authors.initials: F
authors.lastname: Benahmed
authors.forename: George
authors.initials: G
authors.lastname: Dimitrov
authors.forename: Ramana
authors.initials: R
authors.lastname: Madupu
authors.forename: Diana
authors.initials: D
authors.lastname: Radune
authors.forename: Steven
authors.initials: S
authors.lastname: Sullivan
authors.forename: Gopaljee
authors.initials: G
authors.lastname: Jha
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Ishihara
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Alok
authors.initials: A
authors.lastname: Pandey
authors.forename: Vikas
authors.initials: V
authors.lastname: Sharma
authors.forename: Malinee
authors.initials: M
authors.lastname: Sriariyanun
authors.forename: Boris
authors.initials: B
authors.lastname: Szurek
authors.forename: Casiana M
authors.initials: CM
authors.lastname: Vera-Cruz
authors.forename: Karin S
authors.initials: KS
authors.lastname: Dorman
authors.forename: Pamela C
authors.initials: PC
authors.lastname: Ronald
authors.forename: Valérie
authors.initials: V
authors.lastname: Verdier
authors.forename: J Maxwell
authors.initials: JM
authors.lastname: Dow
authors.forename: Ramesh V
authors.initials: RV
authors.lastname: Sonti
authors.forename: Seiji
authors.initials: S
authors.lastname: Tsuge
authors.forename: Volker P
authors.initials: VP
authors.lastname: Brendel
authors.forename: Pablo D
authors.initials: PD
authors.lastname: Rabinowicz
authors.forename: Jan E
authors.initials: JE
authors.lastname: Leach
authors.forename: Frank F
authors.initials: FF
authors.lastname: White
authors.forename: Steven L
authors.initials: SL
authors.lastname: Salzberg
mesh_terms: D017360:Arabidopsis / Q000382:microbiology; D016680:Genome, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D012275:Oryza / Q000382:microbiology; D014974:Xanthomonas / Q000235:genetics* / Q000502:physiology