title: Synthesis of the scalarane sesterterpenoid 16-deacetoxy-12-epi-scalarafuranacetate.
abstract: The marine natural product 16-deacetoxy-12-epi-scalarafuranacetate, isolated from Spongua officinalis , was synthesized in 18 linear steps, starting from (-)-sclareol, with high stereoselectivity and an overall yield of 6.1%. The intermediate 16-deacetoxy-12-epi-scalarafuran could be easily transformed into a series of natural scalarane sesterterpenoids in a few steps.
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
authors.forename: Xi-Bo
authors.initials: XB
authors.lastname: Chen
authors.forename: Qian-Jia
authors.initials: QJ
authors.lastname: Yuan
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Si-Kai
authors.initials: SK
authors.lastname: Hua
authors.forename: Jiangmeng
authors.initials: J
authors.lastname: Ren
authors.forename: Bu-Bing
authors.initials: BB
authors.lastname: Zeng
mesh_terms: D004224:Diterpenes / Q000737:chemistry*; D015394:Molecular Structure; D054830:Sesterterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C569680:16-deacetoxy-12-epi-scalarafuranacetate; D004224:Diterpenes; D054830:Sesterterpenes; C070760:sclareol