title: Increased expression of the PRL-3 gene in human oral squamous cell carcinoma and dysplasia tissues.
abstract: Phosphatase of regenerating liver (PRL) belongs to a class of the protein tyrosine phosphatase family, which is known so far to consist of 3 members, PRL-1, PRL-2, and PRL-3. The aim of this study was to uncover the role of PRL genes in development of oral malignancy. We analyzed expression levels of the 3 PRL genes in 50 human oral squamous cell carcinomas (OSCCs), 11 dysplasia and 12 normal mucosa tissues by a real-time RT-PCR method. PRL-3 but not PRL-1 or PRL-2 expressions were significantly higher in OSCC and dysplasia than in normal mucosa tissues. Additionally, PRL-3 expressions were significantly higher in OSCC tissues harboring dominant-negative p53 or recessive p53 mutation than in those harboring wild-type p53. These results suggest that PRL-3 plays a role in oral cancer development and can be useful as a marker of pre-malignant and malignant lesion of oral mucosa.
authors.affiliation: Division of Cancer-Related Genes, Institute for Genetic Medicine, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Nur Mohammad Monsur
authors.initials: NM
authors.lastname: Hassan
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Hamada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kameyama
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Tada
authors.forename: Koji
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Shoko
authors.initials: S
authors.lastname: Yoshida
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kashiwazaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Akira
authors.initials: A
authors.lastname: Sasaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nagatsuka
authors.forename: Nobuo
authors.initials: N
authors.lastname: Inoue
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Moriuchi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007971:Leukoplakia / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D009062:Mouth Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009154:Mutation / Q000235:genetics; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics
chemical_list: D009363:Neoplasm Proteins; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases