title: Convergent synthesis of the HIJKLM ring system of ciguatoxin CTX3C.
abstract: The HIJKLM ring system of ciguatoxin CTX3C was synthesized in a convergent manner. The key steps were a conjugate addition/alkylation sequence, spiroacetalization, intramolecular allylation, ring-closing metathesis, and hydrogenation to form the 36-α-methyl substituent.
authors.affiliation: Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan. takamura@cc.okayama-u.ac.jp
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Takamura
authors.forename: Naoki
authors.initials: N
authors.lastname: Nishiuma
authors.forename: Takashi
authors.initials: T
authors.lastname: Abe
authors.forename: Isao
authors.initials: I
authors.lastname: Kadota
mesh_terms: D002922:Ciguatoxins / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: C466858:ciguatoxin 3C; D002922:Ciguatoxins