title: Biomarkers associated with metastasis of lung cancer to brain predict patient survival.
abstract: MicroRNAs influence cell physiology; alteration in miRNA regulation can be implicated in carcinogenesis and disease progression. Generally, one miRNA is predicted to regulate several hundred genes, and as a result, miRNAs could serve as a better classifier than gene expression. We combine validated miRNA expression values with imaging features to classify NSCLC brain mets from non-brain mets and identify possible biomarkers of brain mets. This research involves comprehensive miRNA expression profiling, evaluation of normalisation techniques and combination of miRNA with imaging features FDG-PET/CT and CT Scan. The biomarkers were validated on an independent data set to predict potential brain mets.
authors.affiliation: Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA. snasser@tgen.org
authors.forename: Sara
authors.initials: S
authors.lastname: Nasser
authors.forename: Aarati R
authors.initials: AR
authors.lastname: Ranade
authors.forename: Shravan
authors.initials: S
authors.lastname: Sridhar
authors.forename: Lisa
authors.initials: L
authors.lastname: Haney
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Korn
authors.forename: Michael B
authors.initials: MB
authors.lastname: Gotway
authors.forename: Glen J
authors.initials: GJ
authors.lastname: Weiss
authors.forename: Seungchan
authors.initials: S
authors.lastname: Kim
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000556:secondary*; D020869:Gene Expression Profiling; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs