title: Forty years later and the role of plasminogen activator inhibitor type 2/SERPINB2 is still an enigma.
abstract: Plasminogen activator inhibitor (PAI)-2 expression is acutely upregulated in pregnancy, inflammation, infection, and other pathophysiological conditions. Circumstances that prevent PAI-2 upregulation are associated with chronic pathology. Altogether this strongly suggests that PAI-2 is one of the many proteins that maintain homeostasis during damage or stress. However, several functions ranging from a classical serpin to various intracellular roles have been ascribed to PAI-2 and, because none of these have been definitively proven in vivo, to this day its precise role or roles remains an enigma. This review readdresses the evidence supporting a role for PAI-2 in fibrinolysis and proteolysis within extracellular environments and includes a review of the many potential intracellular functions attributed to PAI-2.
authors.affiliation: School of Biological Sciences, University of Wollongong, Wollongong NSW, Australia.
authors.forename: Jodi A
authors.initials: JA
authors.lastname: Lee
authors.forename: Blake J
authors.initials: BJ
authors.lastname: Cochran
authors.forename: Sergei
authors.initials: S
authors.lastname: Lobov
authors.forename: Marie
authors.initials: M
authors.lastname: Ranson
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D017396:Plasminogen Activator Inhibitor 2 / Q000737:chemistry / Q000502:physiology*; D011247:Pregnancy
chemical_list: D017396:Plasminogen Activator Inhibitor 2