title: Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides.
abstract: 8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.
authors.affiliation: Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, CAS, Guangzhou, 510530, PR China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Wang
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Yao
authors.forename: Sheng
authors.initials: S
authors.lastname: Jiang
mesh_terms: D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D006900:Hydroxylation; D007454:Iodides / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis*
chemical_list: D001965:Bromides; D002712:Chlorides; D007454:Iodides; D008024:Ligands; D010636:Phenols; D003300:Copper