title: Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine.
abstract: In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma.
authors.affiliation: Naval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD 20910, USA. ashraful.haque@med.navy.mil
authors.forename: Ashraful
authors.initials: A
authors.lastname: Haque
authors.forename: Françoise
authors.initials: F
authors.lastname: Arnaud
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Teranishi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Okada
authors.forename: Bobby
authors.initials: B
authors.lastname: Kim
authors.forename: Paula F
authors.initials: PF
authors.lastname: Moon-Massat
authors.forename: Charles
authors.initials: C
authors.lastname: Auker
authors.forename: Richard
authors.initials: R
authors.lastname: McCarron
authors.forename: Daniel
authors.initials: D
authors.lastname: Freilich
authors.forename: Anke H
authors.initials: AH
authors.lastname: Scultetus
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology; D001810:Blood Volume / Q000187:drug effects; D004347:Drug Interactions; D015942:Factor VIIa / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006454:Hemoglobins / Q000494:pharmacology* / Q000627:therapeutic use; D006761:Hospitals; D008297:Male; D010100:Oxygen / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D016019:Survival Analysis; D013552:Swine
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; D011994:Recombinant Proteins; C096798:HBOC 201; D015942:Factor VIIa; D010100:Oxygen