title: Exclusion of Class III malocclusion candidate loci in Brazilian families.
abstract: The role played by genetic components in the etiology of the Class III phenotype, a class of dental malocclusion, is not yet understood. Regions that may be related to the development of Class III malocclusion have been suggested previously. The aim of this study was to search for genetic linkage with 6 microsatellite markers (D1S234, D4S3038, D6S1689, D7S503, D10S1483, and D19S566), near previously proposed candidate regions for Class III. We performed a two-point parametric linkage analysis for 42 affected individuals from 10 Brazilian families with a positive Class III malocclusion segregation. Analysis of our data indicated that there was no evidence for linkage of any of the 6 microsatellite markers to a Class III locus at = zero, with data supporting exclusion for 5 of the 6 markers evaluated. The present work reinforces that Class III is likely to demonstrate locus heterogeneity, and there is a dependency of the genetic background of the population in linkage studies.
authors.affiliation: Laboratório de Genética, Departamento de Genética e Morfologia, Campus Darcy Ribeiro, Universidade de Brasília, Asa Norte, CEP 70910900 Brasília, DF, Brazil.
authors.forename: R M
authors.initials: RM
authors.lastname: Cruz
authors.forename: J K
authors.initials: JK
authors.lastname: Hartsfield
authors.forename: G
authors.initials: G
authors.lastname: Falcão-Alencar
authors.forename: D L
authors.initials: DL
authors.lastname: Koller
authors.forename: R W
authors.initials: RW
authors.lastname: Pereira
authors.forename: J
authors.initials: J
authors.lastname: Mah
authors.forename: I
authors.initials: I
authors.lastname: Ferrari
authors.forename: S F
authors.initials: SF
authors.lastname: Oliveira
mesh_terms: D001938:Brazil; D005799:Genes, Dominant; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D056426:Genetic Loci; D008313:Malocclusion, Angle Class III / Q000235:genetics*; D008334:Mandible / Q000002:abnormalities; D018895:Microsatellite Repeats; D010375:Pedigree; D011378:Prognathism / Q000235:genetics*