title: Highly selectively monitoring heavy and transition metal ions by a fluorescent sensor based on dipeptide.
abstract: Fluorescent sensor (DMH) based on dipeptide was efficiently synthesized in solid phase synthesis. The dipeptide sensor shows sensitive response to Ag(I), Hg(II), and Cu(II) among 14 metal ions in 100% aqueous solution. The fluorescent sensor differentiates three heavy metal ions by response type; turn on response to Ag(I), ratiometric response to Hg(II), and turn off detection of Cu(II). The detection limits of the sensor for Ag(I) and Cu(II) were much lower than the EPA's drinking water maximum contaminant levels (MCL). Specially, DMH penetrated live cells and detected intracellular Ag(+) by turn on response. We described the fluorescent change, binding affinity, detection limit for the metal ions. The study of a heavy metal-responsive sensor based on dipeptide demonstrates its potential utility in the environment field.
authors.affiliation: Department of Chemistry, Inha University, Nam-Gu, Inchon-City, Republic of Korea.
authors.forename: Lok Nath
authors.initials: LN
authors.lastname: Neupane
authors.forename: Ponnaboina
authors.initials: P
authors.lastname: Thirupathi
authors.forename: Sujung
authors.initials: S
authors.lastname: Jang
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Jang
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Kim
authors.forename: Keun-Hyeung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D003300:Copper / Q000032:analysis / Q000737:chemistry; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry*; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D042541:Intracellular Space / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D008628:Mercury / Q000032:analysis / Q000737:chemistry; D019216:Metals, Heavy / Q000737:chemistry*; D015203:Reproducibility of Results; D012834:Silver / Q000032:analysis / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques; D013050:Spectrometry, Fluorescence / Q000379:methods*; D028561:Transition Elements / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D004151:Dipeptides; D007477:Ions; D019216:Metals, Heavy; D028561:Transition Elements; D014874:Water Pollutants, Chemical; D012834:Silver; D003300:Copper; D008628:Mercury