title: Enantioselective formal synthesis of palmerolide A.
abstract: Enantioselective formal synthesis of macrolactone palmerolide A, a polyketide marine natural product, is described. Key strategies in the synthesis include the oxidative furan ring-opening of a chiral furyl carbinol for the installation of the 1,4-dienol core and a Jung nonaldol-aldol reaction for the dienamide core.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India. prasad@orgchem.iisc.ernet.in
authors.forename: Kavirayani R
authors.initials: KR
authors.lastname: Prasad
authors.forename: Amit B
authors.initials: AB
authors.lastname: Pawar
mesh_terms: D018942:Macrolides / Q000138:chemical synthesis*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D018942:Macrolides; C522534:palmerolide A