title: Hemoglobin glycation rate constant in non-diabetic Individuals.
abstract: The objectives were as follows: (1) estimating mean value of the overall hemoglobin glycation rate constant (k); (2) analyzing inter-individual variability of k; (3) verifying ability of the hemoglobin A1c (HbA1c) formation model to predict changes of HbA1c during red blood cells cultivation in vitro and to reproduce the clinical data. The mean k estimated in a group of 10 non-diabetic subjects was equal to 1.257 ± 0.114 × 10(-9) L mmol(-1) s(-1). The mean k was not affected by a way of estimation of glycemia. The mean k differed less than 20% from values reported earlier and it was almost identical to the mean values calculated on basis of the selected published data. Analysis of variability of k suggests that inter-individual heterogeneity of HbA1c formation is limited or rare. The HbA1c mathematical model was able to predict changes of HbA1c in vitro resulting from different glucose levels and to reproduce a linear relationship of HbA1c and average glucose obtained in the A1C-Derived Average Glucose Study. This study demonstrates that the glycation model with the same k value might be used in majority of individuals as a tool supporting interpretation of HbA1c in different clinical situations.
authors.affiliation: Department of Biomedical Systems and Technologies, Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland. Piotr.Ladyzynski@ibib.waw.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Ladyżyński
authors.forename: Jan M
authors.initials: JM
authors.lastname: Wójcicki
authors.forename: Marianna I
authors.initials: MI
authors.lastname: Bąk
authors.forename: Stanisława
authors.initials: S
authors.lastname: Sabalińska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kawiak
authors.forename: Piotr
authors.initials: P
authors.lastname: Foltyński
authors.forename: Janusz
authors.initials: J
authors.lastname: Krzymień
authors.forename: Waldemar
authors.initials: W
authors.lastname: Karnafel
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000378:metabolism; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin