title: Controlled release of chlorhexidine antiseptic from microporous amorphous silica applied in open porosity of an implant surface.
abstract: Amorphous microporous silica (AMS) serving as a reservoir for controlled release of a bioactive agent was applied in the open porosity of a titanium coating on a Ti-6Al-4V metal substrate. The pores of the AMS emptied by calcination were loaded with chlorhexidine diacetate (CHX) via incipient wetness impregnation with CHX solution, followed by solvent evaporation. Using this CHX loaded AMS system on titanium substrate sustained release of CHX into physiological medium was obtained over a 10 day-period. CHX released from the AMS coating was demonstrated to be effective in killing planktonic cultures of the human pathogens Candida albicans and Staphylococcus epidermidis. This surface modification of titanium bodies with AMS controlled release functionality for a bioactive compound potentially can be applied on dental and orthopaedic implants to abate implant-associated microbial infection.
authors.affiliation: Centre of Surface Chemistry and Catalysis, K.U.Leuven, Kasteelpark Arenberg 23 Bus 2461, B-3001 Heverlee, Belgium.
authors.forename: Els
authors.initials: E
authors.lastname: Verraedt
authors.forename: Annabel
authors.initials: A
authors.lastname: Braem
authors.forename: Amol
authors.initials: A
authors.lastname: Chaudhari
authors.forename: Karin
authors.initials: K
authors.lastname: Thevissen
authors.forename: Erwin
authors.initials: E
authors.lastname: Adams
authors.forename: Lieve
authors.initials: L
authors.lastname: Van Mellaert
authors.forename: Bruno P A
authors.initials: BP
authors.lastname: Cammue
authors.forename: Joke
authors.initials: J
authors.lastname: Duyck
authors.forename: Jozef
authors.initials: J
authors.lastname: Anné
authors.forename: Jef
authors.initials: J
authors.lastname: Vleugels
authors.forename: Johan A
authors.initials: JA
authors.lastname: Martens
mesh_terms: D000085:Acetates / Q000008:administration & dosage* / Q000494:pharmacology; D000497:Alloys; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D003692:Delayed-Action Preparations; D016062:Porosity; D019736:Prostheses and Implants; D012822:Silicon Dioxide / Q000737:chemistry*; D013212:Staphylococcus epidermidis / Q000187:drug effects; D014025:Titanium / Q000737:chemistry*
chemical_list: D000085:Acetates; D000497:Alloys; D000891:Anti-Infective Agents, Local; D003692:Delayed-Action Preparations; C469946:chlorheridine diacetate; C031462:titanium alloy (TiAl6V4); D012822:Silicon Dioxide; D014025:Titanium