title: Compulsive use of dopamine replacement therapy: a model for stimulant drug addiction?
abstract: The compulsive use of dopamine replacement therapy (DRT) or dopamine dysregulation syndrome (DDS) is one of the behavioural disturbances reported in some patients with Parkinson's disease (PD) and other disorders who are receiving DRT. We draw this phenomenon to the attention of the addiction field as a topic deserving of more systematic study. We outline: the clinical features, epidemiology and clinical correlates of the disorder; the unresolved issues in its definition and diagnosis; and its potential relevance to neurobiological models of psychostimulant addiction. We argue that compulsive DRT use may provide a useful model for drug addiction, while advancing our understanding of the neurobiology of addiction and improving the management of PD patients with the disorder.
authors.affiliation: The University of Queensland, UQ Centre for Clinical Research, Queensland, Australia.
authors.forename: Polly
authors.initials: P
authors.lastname: Ambermoon
authors.forename: Adrian
authors.initials: A
authors.lastname: Carter
authors.forename: Wayne
authors.initials: W
authors.lastname: Hall
authors.forename: Nadeeka
authors.initials: N
authors.lastname: Dissanayaka
authors.forename: John
authors.initials: J
authors.lastname: O'Sullivan
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D003937:Diagnosis, Differential; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000139:chemically induced / Q000175:diagnosis; D015259:Dopamine Agents / Q000009:adverse effects*; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy* / Q000523:psychology; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000209:etiology; D011795:Surveys and Questionnaires; D013577:Syndrome
chemical_list: D000978:Antiparkinson Agents; D000697:Central Nervous System Stimulants; D015259:Dopamine Agents