title: Oxidative stress induced by lambda-cyhalothrin (LTC) in rat erythrocytes and brain: Attenuation by vitamin C.
abstract: The objective of this study was to investigate the propensity of lambda-cyhalothrin (LTC) to induce oxidative stress in blood and brain of male Wistar rats and its possible attenuation by vitamin C. Rats were randomly divided into four groups: group I served as control rats. group II was treated daily with 200mgvit C/(kgbw) administered by intraperitoneal way. Rats of group III have received orally 668ppm LTC. Animals of group IV were treated with LTC and vitamin C. A decrease of some hematologic parameters (RBC, Hb, Ht: p<0.01) and a significant increase of MDA levels (p<0.05) in erythrocytes and brain were observed in LTC group compared to controls. Antioxidant enzyme activities in both tissues were modified in LTC group compared to controls. Administration of vitamin C ameliorated these parameters. Our results indicated the potential effects of LTC to induce oxidative damage in tissues and the ability of vitamin C to attenuate LTC-induced oxidative damage.
authors.affiliation: Animal Physiology Laboratory, Sciences Faculty of Sfax, BP1171, 3000 Sfax Tunisia.
authors.forename: Hamadi
authors.initials: H
authors.lastname: Fetoui
authors.forename: El Mouldi
authors.initials: el M
authors.lastname: Garoui
authors.forename: Fatma
authors.initials: F
authors.lastname: Makni-Ayadi
authors.forename: Najiba
authors.initials: N
authors.lastname: Zeghal