title: Addendum to "Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential" [Mol. Immunol. 48(4) (2011) 497-504].
abstract: Measles virus (MV) V protein blocks type I IFN signaling in MV-infected cells. Previous studies suggested that some MV strains could release the V protein-mediated type I IFN suppression in affected cells by two distinct modes: V protein mutation and production of DI RNA. These two modes of type I interferon regulation involves the IPS-1 (MAVS, Cardif, VISA) pathway (Takaki et al., 2011. Mol. Immunol. 48(4), 497–504). We add the comment to this previous issue that the release of the V protein-mediated suppression of type I IFN occurs only by a laboratory-adapted strain of Edmonston.
authors.affiliation: Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo 060-8638, Japan. seya-tu@pop.med.hokudai.ac.jp
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Seya
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D002460:Cell Line; D006801:Humans; D007370:Interferon Type I / Q000235:genetics / Q000378:metabolism*; D008459:Measles virus / Q000276:immunology*; D010750:Phosphoproteins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism*; D015398:Signal Transduction; D014764:Viral Proteins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D007370:Interferon Type I; C505371:MAVS protein, human; D010750:Phosphoproteins; C069181:V protein, measles virus; D014764:Viral Proteins