title: Peptide-based and polypeptide-based hydrogels for drug delivery and tissue engineering.
abstract: Bio-inspired materials chemistry is an interdisciplinary field in which biological functions and structures are used as inspirations to construct a wide variety of new synthetic materials and devices. Peptide sequences that provide structural, mechanical, chemical, or biological function can be borrowed from nature and fused into synthetic poly(amino acid) chains without replicating the entire natural biomolecular sequence. Supramolecular self-assembly of such rationally designed peptidic sequences is emerging as a promising route to novel biofunctional materials. This chapter highlights recent progress in bio-inspired peptide and polypeptide hydrogels that have potential biomedical and pharmaceutical applications. The focus is on synthetic or biosynthetic poly(amino acid) hydrogels based on α-helical coiled-coils, β-sheets, dipeptides, peptide amphiphiles, elastin-like peptides, and on hybrids of organic polypeptides or polymers functionalized with peptides.
authors.affiliation: Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA. aysegul@udel.edu
authors.forename: Aysegul
authors.initials: A
authors.lastname: Altunbas
authors.forename: Darrin J
authors.initials: DJ
authors.lastname: Pochan
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D004549:Elastin / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D013501:Surface-Active Agents / Q000737:chemistry / Q000378:metabolism*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D000596:Amino Acids; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D010455:Peptides; D013501:Surface-Active Agents; D004549:Elastin