title: Increased PLA2 activity in the hippocampus of patients with temporal lobe epilepsy and psychosis.
abstract: OBJECTIVE
  The aim of this work was to investigate whether increased activity of the enzyme phospholipase A(2) (PLA(2)) in the brain, as frequently reported in schizophrenia, is also related to psychosis in epilepsy. Our working hypothesis was based on the increased prevalence of schizophrenia-like psychosis in patients with temporal lobe epilepsy (TLE) secondary to mesial temporal sclerosis (MTS), as compared to patients with other forms of epilepsy.
  
  
  METHODS
  We determined PLA(2) activity in hippocampal tissue from 7 patients with TLE-MTS and psychosis, as compared to 9 TLE-MTS patients without psychosis. Hippocampal tissue was obtained from patients who underwent an anterior temporal lobectomy due to therapy-resistant epilepsy.
  
  
  RESULTS
  We found that patients with TLE-MTS and psychosis had a significantly increased calcium-independent PLA(2) activity as compared to patients without psychosis (p = 0.016).
  
  
  CONCLUSIONS
  Our finding suggest that an increment in brain PLA(2) activity is not specific for schizophrenia, but rather may be associated to the manifestation of schizophrenia-like psychotic symptoms in general.
authors.affiliation: Laboratory of Neuroscience (LIM27), Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr. Ovídio Pires de Campos 785, 05403-010 São Paulo, Brazil. gattaz@usp.br
authors.forename: Wagner F
authors.initials: WF
authors.lastname: Gattaz
authors.forename: Kette D
authors.initials: KD
authors.lastname: Valente
authors.forename: Nadia R B
authors.initials: NR
authors.lastname: Raposo
authors.forename: Silvia
authors.initials: S
authors.lastname: Vincentiis
authors.forename: Leda L
authors.initials: LL
authors.lastname: Talib
mesh_terms: D000328:Adult; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054467:Phospholipases A2 / Q000378:metabolism*; D011618:Psychotic Disorders / Q000473:pathology*; D011863:Radioimmunoassay / Q000379:methods; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D054467:Phospholipases A2