title: [Review of research approach on allergens of Shuanghuanglian injection and its important research strategy of susceptibility gene].
abstract: Reviewing the progress on study about the major allergen of Shuanghuanglian injection in recent years, resulted in that individual differences of anaphylactic shock are closely related with HLA gene polymorphism. Basing on this, we put forward the research strategy on susceptibility gene of important allergen of Shuanghuanglian injection based on the theory of genetic fingerprints, in order to make sure about the relationship the major allergen of Shuanghuanglian injection and HLA-DRB gene polymorphism and specificity IgE antibody, and to clarify the allergic reaction loci reduced allergic reactions, which can provide the reference data for the study on mechanisms for anaphylactic reaction of Shuanghuanglian injection, and research ideas for the sensitization mechanism of traditional Chinese medicine injection study.
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yanming
authors.initials: Y
authors.lastname: Xie
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000485:Allergens / Q000009:adverse effects; D000707:Anaphylaxis / Q000139:chemically induced* / Q000235:genetics* / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007267:Injections; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D000485:Allergens; D004365:Drugs, Chinese Herbal; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C516400:shuang-huang-lian; D007073:Immunoglobulin E