title: [Kinetic regularities and mechanisms of action of calix[4]arene C-99 on ATPase activity of myosin subfragment-1 of myometrium].
abstract: It has been shown that calix[4]arene C-99 inhibited myosin subfragment-1 ATPase of myometrium. This inhibition is noncompetitive as to ATP and Mg2+. At the same time, this compound reduces the seeming enzymatic hydrolysis maximum rate of nucleoside triphosphate with respect to ATP and Mg2+. With the help of computer design the interaction of mentioned calix[4]arene with myosin subfragment-1 of myometrium has been investigated. Several mechanisms involved in the calix[4]arene C-99 inhibition of myosin head ATPase were supposed and participation of hydrogen, hydrophobic and electrostatic interactions in these mechanisms was discussed.
authors.forename: A A
authors.initials: AA
authors.lastname: Bevza
authors.forename: R D
authors.initials: RD
authors.lastname: Labyntseva
authors.forename: O V
authors.initials: OV
authors.lastname: Bevza
authors.forename: S O
authors.initials: SO
authors.lastname: Cherenok
authors.forename: V I
authors.initials: VI
authors.lastname: Kal'chenko
authors.forename: S O
authors.initials: SO
authors.lastname: Kosterin
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D047250:Calixarenes / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D006868:Hydrolysis / Q000187:drug effects; D007700:Kinetics; D008274:Magnesium / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D032389:Myocytes, Smooth Muscle / Q000201:enzymology*; D009215:Myometrium / Q000166:cytology / Q000201:enzymology*; D015879:Myosin Subfragments / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D009218:Myosins / Q000037:antagonists & inhibitors / Q000378:metabolism; D013552:Swine
chemical_list: D004791:Enzyme Inhibitors; D015879:Myosin Subfragments; D047250:Calixarenes; D000255:Adenosine Triphosphate; D009218:Myosins; D008274:Magnesium