title: Enantiospecific synthesis of pyridinones as versatile intermediates toward asymmetric piperidines.
abstract: The enantiospecific syntheses of pyridinones from amino acids via a gold-catalyzed strategy are reported. Excellent stereocontrol was observed during the cyclization. This approach provides a straightforward tool for further synthetic applications toward piperidines.
authors.affiliation: Equipe Produits Naturels, Synthèse et Chimie Médicinale, UMR 6226 Sciences Chimiques de Rennes, Université de Rennes 1, 2 Avenue du Pr Léon Bernard 35043 Rennes Cedex, France. nicolas.gouault@univ-rennes1.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gouault
authors.forename: Myriam
authors.initials: M
authors.lastname: Le Roch
authors.forename: Adèle
authors.initials: A
authors.lastname: Cheignon
authors.forename: Philippe
authors.initials: P
authors.lastname: Uriac
authors.forename: Michèle
authors.initials: M
authors.lastname: David
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D011728:Pyridones / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D010880:Piperidines; D011728:Pyridones