title: [Anesthesia and perioperative management in a patient with acquired angioedema].
abstract: We experienced anesthesia and perioperative management for hysterectomy in a patient with acquired angioedema. Angioedema due to C1 esterase inhibitor (C1-INH) deficiency (loss or dysfunction of C1-INH) is one of the rarest diseases, and is characterized by recurrent episodes of regional hard edema and ascites induced by mechanical stimuli or mental stress. Edema spreads to the subcutaneous and submucosal layer, and laryngeal edema may cause the upper airway obstruction. Tranexamic acid and C1-INH concentrates were administered perioperatively for prophylaxis of attacks, and combined spinal and epidural anesthesia was performed for hysterectomy. We could manage perioperative care without causing edema.
authors.affiliation: Department of Anesthesiology, Miyazaki Prefectural Nobeoka Hospital, Nobeoka 882-0835.
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Maruta
authors.forename: Machiko
authors.initials: M
authors.lastname: Tateishi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Fujie
authors.forename: Nozomi
authors.initials: N
authors.lastname: Maruta
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Takao
authors.initials: T
authors.lastname: Yano
authors.forename: Taro
authors.initials: T
authors.lastname: Kawano
authors.forename: Isao
authors.initials: I
authors.lastname: Tsuneyoshi
mesh_terms: D000767:Anesthesia, Epidural; D000775:Anesthesia, Spinal; D000799:Angioedema / Q000601:surgery*; D050718:Complement C1 Inhibitor Protein / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007819:Laryngeal Edema / Q000517:prevention & control; D019990:Perioperative Care; D014148:Tranexamic Acid / Q000008:administration & dosage
chemical_list: D050718:Complement C1 Inhibitor Protein; D014148:Tranexamic Acid