title: [Analysis for myeloperoxidase genetic polymorphism in gastric cancer].
abstract: OBJECTIVE
  To investigate the association of myeloperoxidase(MPO) genetic polymorphism and gastric cancer.
  
  
  METHODS
  A case-control study was performed including 62 patients with gastric cancer and 61 healthy controls. Peripheral blood was collected for genetic analysis of MPO-463.
  
  
  RESULTS
  There were no significant differences in gender, age, and smoking between the two groups(P>0.05). However, the two groups differed in drinking, family history of gastric cancer, and Helicobacter pylori(HP) infection(P<0.05). The frequencies of MPO-463GG, GA and AA were 87.1%, 11.3% and 1.6%in the study group, and were 72.1%, 23.0%, and 4.9% in the control group, respectively. Carriers of MPO-463 GA or AA had a significantly higher risk of gastric cancer than those of MPO-463 GG(χ(2)=4.253, P<0.05, OR=0.383, 95% CI: 0.151-0.972). Carriers of G allele had a significantly lower risk of gastric cancer compared to carriers of A allele(χ(2)=4.935, P<0.05, OR=0.399, 95% CI: 0.174-0.916).
  
  
  CONCLUSIONS
  MPO-463 G/A polymorphism is associated with gastric cancer with A being a protective gene.
authors.affiliation: Department of Gastrointestinal Surgery, The Affiliated Hospital of Guiyang Medical University, Guiyang 550004, China. wq5969@sina.com
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Yan
authors.forename: Hai-bin
authors.initials: HB
authors.lastname: Wang
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Xie
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D009195:Peroxidase