title: Collectrin and ACE2 in renal and intestinal amino acid transport.
abstract: Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane of kidney and/or small intestine, where they (re-)absorb amino acids into the body. In this review we present the results concerning the dependence of their apical expression with their association to partner proteins. We will in particular focus on the situation of B0AT1 and B0AT3, that associate with members of the renin-angiotensin system (RAS), namely Tmem27 and angiotensin-converting enzyme 2 (ACE2), in a tissue specific manner. The role of this association in relation to the formation of a functional unit related to Na+ or amino acid transport will be assessed. We will conclude with some remarks concerning the relevance of this association to Hartnup disorder, where some mutations have been shown to differentially interact with the partner proteins.
authors.affiliation: INRA/AgroParisTech, Paris, France. dustin.singer@agroparistech.fr
authors.forename: Dustin
authors.initials: D
authors.lastname: Singer
authors.forename: Simone M R
authors.initials: SM
authors.lastname: Camargo
mesh_terms: D026921:Amino Acid Transport Systems, Neutral / Q000235:genetics / Q000378:metabolism; D000596:Amino Acids / Q000235:genetics / Q000378:metabolism*; D000085962:Angiotensin-Converting Enzyme 2; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D006250:Hartnup Disease / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009928:Organ Specificity / Q000502:physiology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000502:physiology; D012964:Sodium / Q000378:metabolism
chemical_list: D026921:Amino Acid Transport Systems, Neutral; D000596:Amino Acids; C429534:CLTRN protein, human; D008562:Membrane Glycoproteins; C491436:SLC6A19 protein, human; C505021:SLC6A19 protein, mouse; C504407:Tmem27 protein, mouse; D012964:Sodium; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; C000705328:Ace2 protein, mouse; D000085962:Angiotensin-Converting Enzyme 2