title: Copper-catalyzed reductive coupling of tosylhydrazones with amines: a convenient route to α-branched amines.
abstract: A general procedure for the reductive coupling of N-tosylhydrazones with amines in the presence of Cu(acac)(2) and Cs(2)CO(3) has been developed. The protocol is very effective and chemoselective with various primary and secondary aliphatic amines, aminoalcohols as well as azole derivatives to give α-branched amines in good yields.
authors.affiliation: Université Paris-Sud 11, CNRS, BioCIS UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Châtenay-Malabry, France. abdallah.hamze@u-psud.fr
authors.forename: Abdallah
authors.initials: A
authors.lastname: Hamze
authors.forename: Bret
authors.initials: B
authors.lastname: Tréguier
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Brion
authors.forename: Mouâd
authors.initials: M
authors.lastname: Alami
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000588:Amines; D006835:Hydrazones; D003300:Copper