title: Regional homogeneity changes in heavy male smokers: a resting-state functional magnetic resonance imaging study.
abstract: Recent studies have documented declined global cognitive function and abnormal task-related brain activation in chronic cigarette smokers. However, the effects of long-term heavy smoking on task-independent baseline brain activity are still unknown. Here, we used a regional homogeneity (ReHo) method combined with functional magnetic resonance imaging (fMRI) to investigate spontaneous neural activity in the resting state in heavy smokers. Compared with controls, heavy smokers exhibited decreased ReHo in prefrontal regions, as well as increased ReHo in insula and posterior cingulate cortex. Our study may better our understanding of the neurobiological consequences of smoking.
authors.affiliation: Department of Psychology, South China Normal University, Guangzhou, China.
authors.forename: Rongjun
authors.initials: R
authors.lastname: Yu
authors.forename: Liyan
authors.initials: L
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Yuan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology*; D002908:Chronic Disease; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D012146:Rest / Q000502:physiology; D012907:Smoking / Q000009:adverse effects / Q000503:physiopathology*; D014029:Tobacco Use Disorder / Q000503:physiopathology*