title: Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
abstract: Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a replication study consisting of a total of 7,171 individuals with adult asthma (cases) and 27,912 controls in the Japanese population, we identified five loci associated with susceptibility to adult asthma. In addition to the major histocompatibility complex and TSLP-WDR36 loci previously reported, we identified three additional loci: a USP38-GAB1 locus on chromosome 4q31 (combined P = 1.87 × 10(-12)), a locus on chromosome 10p14 (P = 1.79 × 10(-15)) and a gene-rich region on chromosome 12q13 (P = 2.33 × 10(-13)). We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07 × 10(-23)), which is close to rs2070600, a SNP previously reported for association with FEV(1)/FVC in genome-wide association studies for lung function. Our findings offer a better understanding of the genetic contribution to asthma susceptibility.
authors.affiliation: Laboratory for Respiratory Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan.
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Hirota
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Kaori
authors.initials: K
authors.lastname: Tomita
authors.forename: Satoru
authors.initials: S
authors.lastname: Doi
authors.forename: Kimie
authors.initials: K
authors.lastname: Fujita
authors.forename: Akihiko
authors.initials: A
authors.lastname: Miyatake
authors.forename: Tadao
authors.initials: T
authors.lastname: Enomoto
authors.forename: Takehiko
authors.initials: T
authors.lastname: Miyagawa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Adachi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Akio
authors.initials: A
authors.lastname: Niimi
authors.forename: Hisako
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Isao
authors.initials: I
authors.lastname: Ito
authors.forename: Hironori
authors.initials: H
authors.lastname: Masuko
authors.forename: Tohru
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hizawa
authors.forename: Masami
authors.initials: M
authors.lastname: Taniguchi
authors.forename: John J
authors.initials: JJ
authors.lastname: Lima
authors.forename: Charles G
authors.initials: CG
authors.lastname: Irvin
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Peters
authors.forename: Blanca E
authors.initials: BE
authors.lastname: Himes
authors.forename: Augusto A
authors.initials: AA
authors.lastname: Litonjua
authors.forename: Kelan G
authors.initials: KG
authors.lastname: Tantisira
authors.forename: Scott T
authors.initials: ST
authors.lastname: Weiss
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tamari
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide