title: MicroRNAs and vascular (dys)function.
abstract: MicroRNAs (miRNAs) are small non-coding RNAs, that control diverse cellular functions by either promoting degradation or inhibition of target messenger RNA translation. An aberrant expression profile of miRNAs has been linked to human diseases, including cardiovascular dysfunction. This review summarizes the latest insights in the identification of vascular-specific miRNAs and their targets, as well as their roles and mechanisms in the vasculature. Furthermore, we discuss how manipulation of these miRNAs could represent a novel therapeutic approach in the treatment of vascular dysfunction.
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.
authors.forename: Dorothee
authors.initials: D
authors.lastname: Hartmann
authors.forename: Thomas
authors.initials: T
authors.lastname: Thum
mesh_terms: D043924:Angiogenesis Modulating Agents / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D035683:MicroRNAs / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D058990:Molecular Targeted Therapy; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D009843:Oligoribonucleotides / Q000627:therapeutic use; D020320:Oligoribonucleotides, Antisense / Q000627:therapeutic use
chemical_list: D043924:Angiogenesis Modulating Agents; D035683:MicroRNAs; D009843:Oligoribonucleotides; D020320:Oligoribonucleotides, Antisense