title: [Laboratory diagnosis of atherosclerotic plaque damage in patients with coronary heart disease: PAPP-A (a review of literature)].
abstract: Vascular inflammation is a major pathogenetic factor for the progression of an atherosclerotic process and for the development of destructive plaque changes. Now an active search is under way for markers to diagnose acute coronary syndrome at the early stage of development. The paper discusses the role of markers of inflammation and endogenous destruction in the development of atherosclerotic plaque instability. Pregnancy-associated plasma protein A (PAPP-A) is its most promising marker. It may be used to stratify the risk of cardiovascular complications in coronary heart disease and to assess their prognosis.
authors.forename: A O
authors.initials: AO
authors.lastname: Shevchenko
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Slesareva
authors.forename: O P
authors.initials: OP
authors.lastname: Shevchenko
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D003327:Coronary Disease / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D003331:Coronary Vessels / Q000473:pathology; D042241:Early Diagnosis; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D007249:Inflammation; D058226:Plaque, Atherosclerotic / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D011266:Pregnancy-Associated Plasma Protein-A