title: Relation of plasma levels of adiponectin to left ventricular diastolic dysfunction in patients undergoing cardiac catheterization for coronary artery disease.
abstract: In the present study, we hypothesized that hypoadiponectinemia and hyperleptinemia might be associated with left ventricular (LV) diastolic dysfunction. To test the hypothesis, we examined the relation of the plasma levels of adiponectin and leptin with the indexes of LV diastolic and systolic function (relaxation time constant, end-diastolic pressure, and ejection fraction) in 193 consecutive patients undergoing cardiac catheterization for coronary artery disease (age 69 ± 9 years, 74% men; ejection fraction 68.4 ± 9.9%). Regardless of gender, the adiponectin levels correlated negatively with the relaxation time constant and end-diastolic pressure, and the correlations remained significant after adjustment for potential confounders, including age, body mass index, heart rate, blood pressure, and coronary artery disease severity. Adiponectin levels did not significantly correlate with the ejection fraction in either men or women. The leptin levels did not significantly correlate with the indexes of LV diastolic or systolic function in either men or women. In conclusion, we found that decreased adiponectin levels were associated with LV diastolic dysfunction in patients with known or suspected coronary artery disease.
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan. fukuta-h@med.nagoya-cu.ac.jp
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Fukuta
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohte
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Wakami
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Goto
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Tani
authors.forename: Genjiro
authors.initials: G
authors.lastname: Kimura
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D006328:Cardiac Catheterization; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D003971:Diastole; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D055414:Myocardial Perfusion Imaging; D011379:Prognosis; D011863:Radioimmunoassay; D012720:Severity of Illness Index; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000150:complications / Q000503:physiopathology
chemical_list: D052242:Adiponectin; D015415:Biomarkers