title: Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI.
abstract: Alzheimer's disease (AD) and mild cognitive impairment (MCI), the transitional clinical stage between cognition in normal aging and dementia, have been linked to abnormalities in brain perfusion. Pulsed arterial spin labeling (PASL) is a magnetic resonance imaging (MRI) technique for evaluating brain perfusion. The present study aimed to determine regional perfusion abnormalities in 19 patients with mild dementia in AD and 24 patients with MCI as compared to 24 cognitively healthy elderly controls using PASL. In line with nuclear imaging methods, lower perfusion in patients with MCI and AD was found mainly in the parietal lobe, but also in angular and middle temporal areas as well as in the left middle occipital lobe and precuneus. Our data imply that PASL may be a valuable instrument for investigating perfusion changes in the transition from normal aging to dementia and indicate that it might become an alternative to nuclear imaging techniques in AD diagnostics.
authors.affiliation: Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der TU München, Ismaninger Str. 22, 81675, München, Germany. panos.alexopoulos@lrz.tu-muenchen.de
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Alexopoulos
authors.forename: Christian
authors.initials: C
authors.lastname: Sorg
authors.forename: Annette
authors.initials: A
authors.lastname: Förschler
authors.forename: Timo
authors.initials: T
authors.lastname: Grimmer
authors.forename: Maria
authors.initials: M
authors.lastname: Skokou
authors.forename: Afra
authors.initials: A
authors.lastname: Wohlschläger
authors.forename: Robert
authors.initials: R
authors.lastname: Perneczky
authors.forename: Claus
authors.initials: C
authors.lastname: Zimmer
authors.forename: Alexander
authors.initials: A
authors.lastname: Kurz
authors.forename: Christine
authors.initials: C
authors.lastname: Preibisch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology*; D000704:Analysis of Variance; D001931:Brain Mapping; D002560:Cerebrovascular Circulation; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000503:physiopathology*; D003704:Dementia / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D055420:Perfusion Imaging / Q000379:methods*; D011569:Psychiatric Status Rating Scales; D013113:Spin Labels
chemical_list: D013113:Spin Labels