title: Anti-inflammatory activity of Premna corymbosa (Burm.f.) Rottl. & Willd. leaves extracts in Wistar albino rats.
abstract: OBJECTIVE
  To evaluate the acute toxicity and to investigate the effect of Premna corymbosa ethanolic extract (PCEE) at doses of 200 and 400 mg/kg body weight in acute and chronic models of inflammation in experimental animals.
  
  
  METHODS
  In the acute toxicity study, a single dose of PCEE of 2 000 mg/kg body weight, p.o. was administered and observed for 48 h. In acute models as egg albumin induced paw edema and chronic model as cotton pellet methods was followed.
  
  
  RESULTS
  In acute models, egg albumin induced paw edema PCEE significantly (P<0.01) inhibited the edema formation. In chronic model, cotton pellet induced granuloma formation in rats PCEE significantly (P<0.01) reduced the granuloma formation with percentage inhibition of 35.17% and 50.38 % respectively.
  
  
  CONCLUSIONS
  The present study establishes the antiinflammatory activity of Premna corymbosa leaves.
authors.affiliation: Department of Pharmacology, Al Shifa College of Pharmacy, Poonthavanam, Kizhattur Perinthalmanna, Malappuram - 679325 Kerala State, India. karthikeyanpgt@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Karthikeyan
authors.forename: M K
authors.initials: MK
authors.lastname: Deepa
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D029648:Verbenaceae / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts