title: An association analysis of Per2 with panic disorder in the Japanese population.
abstract: Panic disorder (PD) is a severe and chronic psychiatric disorder, with genetic components underlying in its etiology. The PERIOD2 (Per2) gene has been reported to be associated with familial advanced sleep phase syndrome. Considering the high frequency of sleep disturbance in PD, Per2 may be a candidate gene for PD. Therefore, we conducted a two-stage case-control association study in the Japanese population. In the first screening sample of 203 patients and 409 controls, we investigated three single-nucleotide polymorphisms in Per2. We found a potential association in the screening sample (rs2304672, genotype P=0.046, uncorrected), whereas we could not replicate the association in the second sample of 460 patients and 460 controls. Our results suggest that Per2 may not have a major role in the pathogenesis of PD in the Japanese population.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. totowa-psy@umin.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otowa
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Nagisa
authors.initials: N
authors.lastname: Sugaya
authors.forename: Eiji
authors.initials: E
authors.lastname: Yoshida
authors.forename: Ken
authors.initials: K
authors.lastname: Inoue
authors.forename: Shin
authors.initials: S
authors.lastname: Yasuda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umekage
authors.forename: Takashi
authors.initials: T
authors.lastname: Ebisawa
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tanii
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Kaiya
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000235:genetics*; D056950:Period Circadian Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D055815:Young Adult
chemical_list: C421902:PER2 protein, human; D056950:Period Circadian Proteins