title: Predictive performance of prostate cancer risk in Chinese men using 33 reported prostate cancer risk-associated SNPs.
abstract: BACKGROUND
  Genome-wide association studies (GWAS) have identified more than 30 single nucleotide polymorphisms (SNPs) that were reproducibly associated with prostate cancer (PCa) risk in populations of European descent. In aggregate, these variants have shown potential to predict risk for PCa in European men. However, their utility for PCa risk prediction in Chinese men is unknown.
  
  
  METHODS
  We selected 33 PCa risk-related SNPs that were originally identified in populations of European descent. Genetic scores were estimated for subjects in a Chinese case-control study (1,108 cases and 1,525 controls) based on these SNPs. To assess the performance of the genetic score on its ability to predict risk for PCa, we calculated area under the curve (AUC) of the receiver operating characteristic (ROC) in combination with 10-fold cross-validation.
  
  
  RESULTS
  The genetic score was significantly higher for cases than controls (P = 5.91 × 10(-20)), and was significantly associated with risk of PCa in a dose-dependent manner (P for trend: 4.78 × 10(-18)). The AUC of the genetic score was 0.604 for risk prediction of PCa in Chinese men. When ORs derived from this Chinese study population were used to calculate genetic score, the AUCs were 0.631 for all 33 SNPs and 0.617 when using only the 11 significant SNPs.
  
  
  CONCLUSIONS
  Our results indicate that genetic variants related to PCa risk may be useful for risk prediction in Chinese men. Prospective studies are warranted to further evaluate these findings.
authors.affiliation: Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Lin
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
authors.forename: Haowen
authors.initials: H
authors.lastname: Jiang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
authors.forename: Guangfu
authors.initials: G
authors.lastname: Jin
authors.forename: Ann W
authors.initials: AW
authors.lastname: Hsing
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shao
authors.forename: Jun
authors.initials: J
authors.lastname: Qi
authors.forename: Yu
authors.initials: Y
authors.lastname: Ye
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
authors.forename: Guozeng
authors.initials: G
authors.lastname: Wang
authors.forename: Lisa W
authors.initials: LW
authors.lastname: Chu
authors.forename: Jun
authors.initials: J
authors.lastname: Ouyang
authors.forename: Yichen
authors.initials: Y
authors.lastname: Huang
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Chen
authors.forename: Yutang
authors.initials: Y
authors.lastname: Gao
authors.forename: Rong
authors.initials: R
authors.lastname: Shi
authors.forename: Qijun
authors.initials: Q
authors.lastname: Wu
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Hu
authors.forename: Jielin
authors.initials: J
authors.lastname: Sun
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.forename: Xu
authors.initials: X
authors.lastname: Gao
authors.forename: Chuanliang
authors.initials: C
authors.lastname: Xu
authors.forename: Zengnan
authors.initials: Z
authors.lastname: Mo
authors.forename: Yinghao
authors.initials: Y
authors.lastname: Sun
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
mesh_terms: D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D019540:Area Under Curve; D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D012372:ROC Curve; D012307:Risk Factors