title: [Oxidative stress biomarkers as indicator of chronic inflammatory joint diseases stage].
abstract: OBJECTIVE
  To evaluate the participation of oxidative stress (OS) on chronic inflammatory joint disease (CIJD), as well as its possible use as a diagnostic biomarker.
  
  
  METHODS
  The study population comprised 29 patients with CIJD: 18 with rheumatoid arthritis (RA: 13 active/5 inactive); 11 with ankylosing spondylitis (AS: 7 active/4 inactive) and 13 healthy subjects. Activity of the disease was assessed by: RA patients, Disease Activity Score (DAS 28) and AS patients by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Oxidative stress biomarkers were determined in plasma using spectrophotometrical techniques. The statistical analysis was carried out using the SSPS statistical package.
  
  
  RESULTS
  Active CIJD showed a high oxidative stress characterized by increases in oxidative damage markers and a reduction in antioxidative systems, together with a higher myeloperoxidase (MPO) concentration. Inactive CIJD only showed changes in oxidized glutathione (GSSG) and reduced glutathione (GSH)/GSSG ratio levels, without changes in oxidative damage parameters or in antioxidative systems.
  
  
  CONCLUSIONS
  Our data revealed that: i) CIJD presents with a high oxidative stress; ii) inactive CIJD shows a production of reactive species without triggering oxidative damage and maintaining red-ox homeostasis, and iii) the combination of oxidative stress biomarkers may be used as markers of active-inactive stages of CIJD.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Córdoba, España.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Feijóo
authors.forename: Isaac
authors.initials: I
authors.lastname: Túnez
authors.forename: Adela
authors.initials: A
authors.lastname: Ruiz
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Tasset
authors.forename: Elisa
authors.initials: E
authors.lastname: Muñoz
authors.forename: Eduardo
authors.initials: E
authors.lastname: Collantes