title: Ovarian cancer risk assessment: a tool for preoperative assessment.
abstract: OBJECTIVE
  The objective of this pilot study was to determine if the combination of CA 125, menopausal status and prealbumin can be used to accurately predict ovarian cancer in women with pelvic masses.
  
  
  METHODS
  Preoperative serum CA 125, prealbumin and menopausal status were prospectively determined. Results were formulated into an ovarian cancer risk assessment (OCRA) score and compared with final surgical pathology.
  
  
  RESULTS
  OCRA was studied in 130 women. No cancers were found in women with a score less than 200. For all cancers, an OCRA score ≥ 200 had a sensitivity of 96%, specificity of 95% and positive predictive value of 95%. When the OCRA score of ≥ 200 was evaluated for its ability to predict ovarian cancer, the sensitivity, specificity, and positive predictive value were 100%, 83%, and 78%, respectively.
  
  
  CONCLUSIONS
  In this pilot study, OCRA was able to predict which women with pelvic masses were more likely to have ovarian cancer. The scoring system easily applied clinically and may help facilitate appropriate referral of women to gynecologic oncologists for optimal care.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toledo Medical Center, 3120 Glendale Avenue, Mail Stop 1194, Toledo, OH 43614, United States.
authors.forename: Deb A
authors.initials: DA
authors.lastname: Ronco
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Manahan
authors.forename: John P
authors.initials: JP
authors.lastname: Geisler
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D010865:Pilot Projects; D011228:Prealbumin / Q000032:analysis*; D011237:Predictive Value of Tests; D011300:Preoperative Care; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D011228:Prealbumin