title: Increased risk for gastric cancer in carriers of the lymphotoxin-α+252G variant infected by Helicobacter pylori.
abstract: The objective of this study is to determine whether polymorphisms in the lymphotoxin-α (LTA) and interleukin-10 (IL-10) genes were associated with gastric cancer (GC) in a Chinese population. One hundred ninety-six patients with GC and 248 healthy individuals were enrolled in this case-control study. The LTA 252G was associated with an increased risk of GC, with an adjusted odds ratio (OR) of 1.74 (95% confidence interval [CI]: 1.12-2.69) for the LTA 252G heterozygotes and 2.42 (95% CI: 1.28-4.58) for the LTA 252G homozygotes as compared with noncarriers. In contrast, such association is not found in polymorphisms in IL-10; however, a potential interaction between LTA +252 G allele and IL-10-1082 G/A was found to be associated with the occurrence of GC (adjusted OR: 1.91; 95% CI: 1.01-3.64). This study indicates that the LTA +252G allele is associated with increased risk for the presence of GC in a Helicobacter pylori infection positive subgroup and potential interaction between IL-10 and LTA may contribute to the risk of GC.
authors.affiliation: Central Lab, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: Bangshun
authors.initials: B
authors.lastname: He
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Pan
authors.forename: Yeqiong
authors.initials: Y
authors.lastname: Xu
authors.forename: Zhenlin
authors.initials: Z
authors.lastname: Nie
authors.forename: Liping
authors.initials: L
authors.lastname: Chen
authors.forename: Ling
authors.initials: L
authors.lastname: Gu
authors.forename: Shukui
authors.initials: S
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016480:Helicobacter pylori / Q000502:physiology; D006579:Heterozygote; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D017354:Point Mutation / Q000502:physiology; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology / Q000473:pathology
chemical_list: D008233:Lymphotoxin-alpha