title: An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile.
abstract: A three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile catalyzed by silver triflate under mild conditions is reported, which generates pyrazolo[5,1-a]isoquinolin-2-amines in good to excellent yields.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.
authors.forename: Xingxin
authors.initials: X
authors.lastname: Yu
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Honglei
authors.initials: H
authors.lastname: Lou
authors.forename: Yiyuan
authors.initials: Y
authors.lastname: Peng
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis*; D001547:Benzaldehydes / Q000737:chemistry*; D002384:Catalysis; D007546:Isoquinolines / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013830:Thiadiazoles / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000588:Amines; D001547:Benzaldehydes; D007546:Isoquinolines; D009570:Nitriles; D011720:Pyrazoles; D013830:Thiadiazoles; C012563:sulfohydrazide; D012834:Silver; C039109:isoquinoline