title: Association between diabetes mellitus and breast cancer risk: a meta-analysis of the literature.
abstract: OBJECTIVE
  Diabetes and breast cancer are both serious life-threatening diseases across the world. Some studies shows that diabetes is associated with many kinds of tumor, but links with breast cancer remain controversial. The aim of this study was to assess the association the available evidence.
  
  
  METHODS
  A meta-analysis was conducted including 16 studies published between 2000 and 2010 and summary relative risks(RRs) with 95% CIs were calculated using random-effects model.
  
  
  RESULTS
  The combined evidence supports that diabetes was associated with a statistically significant 23% increased risk of breast cancer, especially in postmenopausal women (RR=1.25 95%CI 1.20-1.29). The correlation between diabetes and breast cancer was the most obvious in Europe (RR=1.88,95%CI:1.56-2.25), followed by America (RR=1.16, 95%CI:1.12-1.20). In Asia the result was not significant (RR=1.01, 95%CI=0.84-1.21). Diabetes also increased mortality from breast cancer overall (RR=1.44, 95%CI:1.31-1.58).
  
  
  CONCLUSIONS
  This meta-analysis indicated that diabetes can be considered as a risk factor for breast cancer. In addition, menstruation status as well as geographical distribution can affect the relationship.
authors.affiliation: Department of Thyroid and Breast Surgery, Renmin Hospital, Wuhan, China.
authors.forename: Shichong
authors.initials: S
authors.lastname: Liao
authors.forename: Jinxin
authors.initials: J
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Wei
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Li
authors.forename: Changhua
authors.initials: C
authors.lastname: Wang
authors.forename: Shenrong
authors.initials: S
authors.lastname: Sun
mesh_terms: D000569:Americas / Q000453:epidemiology; D001208:Asia / Q000453:epidemiology; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000401:mortality; D016022:Case-Control Studies; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D017698:Postmenopause; D011446:Prospective Studies; D012107:Research Design; D012307:Risk Factors