title: (-)-Hydroxylindestrenolide, a new sesquiterpenoid from a gorgonian coral Menella sp. (Plexauridae).
abstract: (-)-Hydroxylindestrenolide (1), an enantiomer of the known sesquiterpenoid, (+)-hydroxylindestrenolide (2), was isolated from a gorgonian coral identified as Menella sp. The structure, including the relative stereochemistry of 1 was established by spectroscopic methods and by comparison the spectral and physical data with those of 2. Sesquiterpenoid 1 exhibited marginal cytotoxicity toward HL-60 and K562 leukemia tumor cells, and displayed a weak inhibitory effect on superoxide anion generation at a concentration of 10 µg/ml by human neutrophils.
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Taiwan.
authors.forename: Shih-Yao
authors.initials: SY
authors.lastname: Kao
authors.forename: Yu-Chia
authors.initials: YC
authors.lastname: Chang
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.forename: Yung-Husan
authors.initials: YH
authors.lastname: Chen
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D007938:Leukemia / Q000188:drug therapy; D009504:Neutrophils / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism; D013481:Superoxides / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C568211:hydroxylindestrenolide; D013481:Superoxides