title: Suppression of 18F-FDG Myocardial Uptake Using a Fat-Allowed, Carbohydrate-Restricted Diet.
abstract: Patients prepared by the generally used fasting protocol show variable myocardial (18)F-FDG uptake, which may result in difficult interpretation of mediastinal (18)F-FDG uptake. This retrospective study described the effect of a 1-d fat-allowed, carbohydrate-restricted diet on myocardial (18)F-FDG uptake.
  
  
  METHODS
  The study included 100 patients on a carbohydrate-restricted diet from the Medical Center Leeuwarden and 100 patients on an unrestricted diet from the University Medical Center of Utrecht. A visual uptake scale was used, with category 0 indicating myocardial uptake less than liver uptake, category 1 indicating myocardial uptake comparable to liver uptake, and category 2 indicating myocardial uptake considerably higher than liver uptake.
  
  
  RESULTS
  After a carbohydrate-restricted diet, 68% of patients had a homogeneously low myocardial uptake of (18)F-FDG (category 0), 14% had moderate myocardial uptake (category 1), and 18% had homogeneously intense myocardial uptake (category 2). Without a carbohydrate-restricted diet, 69% of patients showed a homogeneously intense myocardial uptake (category 2), 16% a moderate myocardial uptake (category 1), and 15% a homogeneously low myocardial uptake (category 0).
  
  
  CONCLUSIONS
  A fat-allowed, carbohydrate-restricted diet starting the day before (18)F-FDG administration suppresses myocardial (18)F-FDG uptake satisfactorily.
authors.affiliation: Department of Nuclear Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands. hans.balink@znb.nl
authors.forename: Hans
authors.initials: H
authors.lastname: Balink
authors.forename: Evelien
authors.initials: E
authors.lastname: Hut
authors.forename: Thomas
authors.initials: T
authors.lastname: Pol
authors.forename: Freerk-Jan
authors.initials: FJ
authors.lastname: Flokstra
authors.forename: Mark
authors.initials: M
authors.lastname: Roef
mesh_terms: D050528:Diet, Carbohydrate-Restricted; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012189:Retrospective Studies
chemical_list: D004041:Dietary Fats; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18