title: Primary cutaneous CD30+ T-cell lymphoproliferative disorder presenting as paraphimosis: a case report and review of the literature.
abstract: Primary cutaneous CD30+ T-cell lymphoproliferative disorders (PC-CD30+ LPD) as a group are one of the more common types of T-cell lymphoma. More specifically primary cutaneous anaplastic lymphoma (PC-ALCL), one of these lymphoproliferative disorders, is the second most common cutaneous T-cell lymphoma. We report an unusual presentation of PC-ALCL. A 90-year-old, uncircumcised male presented with a 3-week history of painful penile swelling and discharge. The patient was treated with cephalexin and underwent emergent circumcision for paraphimosis. The diagnosis of ALCL was made on microscopic evaluation of the foreskin along with follow-up staging studies. A literature review revealed 31 previously reported cases of penile lymphoma, one of which reported a primary penile CD30+ T-cell lymphoma similar to ours. Only one case report described a lymphoma presenting as paraphimosis. Our case is the second reported case of PC-ALCL of the penis and the first of its kind to present as paraphimosis. Lymphomas must be included in the differential diagnosis of penile lesions and paraphimosis. When present, clinicians should be able to differentiate primary cutaneous lymphoma from lymphomas with secondary skin involvement. All foreskins should be submitted to pathology for proper evaluation of penile lesions.
authors.affiliation: Department of Pathology and Cell Biology, University of South Florida, Tampa, Florida, USA. pmoody@health.usf.edu
authors.forename: Patricia Moody
authors.initials: PM
authors.lastname: McNab
authors.forename: Drazen M
authors.initials: DM
authors.lastname: Jukic
authors.forename: Omie
authors.initials: O
authors.lastname: Mills
authors.forename: Irwin
authors.initials: I
authors.lastname: Browarsky
mesh_terms: D000369:Aged, 80 and over; D002944:Circumcision, Male; D003937:Diagnosis, Differential; D052816:Foreskin / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis*; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008297:Male; D010263:Paraphimosis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D010412:Penile Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery
chemical_list: D017730:Ki-1 Antigen