title: Effect of exercise training on the cardiovascular and biochemical parameters in women with eNOS gene polymorphism.
abstract: BACKGROUND
  Presence of endothelial nitric oxide synthase (eNOS) gene polymorphism has been associated with cardiovascular disease (CVD) whereas exercise training (EX) promotes beneficial effects on CVD which is related to increased nitric oxide levels (NO).
  
  
  OBJECTIVE
  To evaluate if women with eNOS gene polymorphism at position-G894T would be less responsive to EX than those who did not carry T allele.
  
  
  METHODS
  Women were trained 3 days/week, 40 minutes session during 6 months. Cardio-biochemical parameters and genetic analysis were performed in a double-blind fashion.
  
  
  RESULTS
  Plasma NOx- levels were similar in both groups at baseline (GG genotype: 18.44±3.28 μM) and (GT+TT genotype: 17.19±2.43 μM) and after EX (GG: 29.20±4.33 and GT+TT: 27.38±3.12 μM). A decrease in blood pressure was also observed in both groups.
  
  
  CONCLUSIONS
  The presence of eNOS polymorphism does not affect the beneficial effects of EX in women.
authors.affiliation: Laboratory of Cardiovascular Research and Physical Activity, Institute of Bioscience, University of São Paulo State (UNESP), Rio Claro (SP), Brazil.
authors.forename: Tiago M
authors.initials: TM
authors.lastname: Rezende
authors.forename: Carlos H G
authors.initials: CH
authors.lastname: Sponton
authors.forename: Pamella A
authors.initials: PA
authors.lastname: Malagrino
authors.forename: Marcos A C
authors.initials: MA
authors.lastname: Bezerra
authors.forename: Carla F F
authors.initials: CF
authors.lastname: Penteado
authors.forename: Angelina
authors.initials: A
authors.lastname: Zanesco
mesh_terms: D000483:Alleles; D001794:Blood Pressure; D001938:Brazil; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000235:genetics / Q000517:prevention & control*; D016022:Case-Control Studies; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009569:Nitric Oxide / Q000096:biosynthesis / Q000097:blood*; D052250:Nitric Oxide Synthase Type III / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III