title: Frailty models: Applications to biomedical and genetic studies.
abstract: In survival analysis, frailty models are potential choices for modeling unexplained heterogeneity in a population. This tutorial presents an overview and general framework of frailty modeling and estimation for multiplicative hazards models in the context of biomedical and genetic studies. Other topics in frailty models, such as diagnostic methods for model adequacy and inference in frailty models, are also discussed. Examples of analyses using multivariate frailty models in a non-parametric hazards setting on biomedical datasets are provided, and the implications of choosing to use frailty and relevance to genetic applications are discussed.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. usha@alum.bu.edu
authors.forename: Usha S
authors.initials: US
authors.lastname: Govindarajulu
authors.forename: Haiqun
authors.initials: H
authors.lastname: Lin
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Lunetta
authors.forename: R B
authors.initials: RB
authors.lastname: D'Agostino
mesh_terms: D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D011157:Population Dynamics; D016016:Proportional Hazards Models; D016019:Survival Analysis