title: Pubertal exposure to bisphenol A disrupts behavior in adult C57BL/6J mice.
abstract: Bisphenol A (BPA) is a widespread endocrine disrupting chemical that influences adult physiology and behavior after perinatal exposure. However, it is not clear if pubertal exposure to BPA exerts hormone dependent effects on behaviors. Using C57BL/6J mice, we sought to determine how pubertal exposure to BPA affects locomotion, exploration, anxiety and sociability in adulthood. Compared to controls, pubertal exposure to BPA or E(2) (17β-estradiol) significantly altered female exploratory and anxiety behavior. Moreover, BPA and E(2)-treated female mice displayed increased levels of affiliation to female stimulus mice and decreased levels of affiliation to male stimulus mice; while our control males showed affiliation preference to female stimulus. These results indicate that pubertal exposure to BPA or E(2) may masculinize female social and emotional behavior.
authors.affiliation: Institute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.
authors.forename: Chengjun
authors.initials: C
authors.lastname: Yu
authors.forename: Fadao
authors.initials: F
authors.lastname: Tai
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Song
authors.forename: Ruiyong
authors.initials: R
authors.lastname: Wu
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.forename: Fengqin
authors.initials: F
authors.lastname: He
mesh_terms: D000818:Animals; D001007:Anxiety / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects*; D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors / Q000633:toxicity*; D004958:Estradiol / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D007398:Interpersonal Relations; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D010636:Phenols / Q000633:toxicity*; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000187:drug effects; D012919:Social Behavior; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004958:Estradiol; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds