title: Association of body mass index and alcohol intake with hypertension subtypes among HAN Chinese.
abstract: Obesity and excessive drinking are major risk factors for development of hypertension. We aimed to explore association of body mass index (BMI) and alcohol intake with isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and combined systolic/diastolic hypertension (SDH) among Shandong Shengli Oil field workers. A total of 26,681 subjects were cross-sectionally analyzed. Statistical calculations included polytomous logistic regression and interaction analysis. After assigning normotensives as a reference, the odds of being ISH decreased by 4% for moderate drinkers, whereas that of being IDH and SDH increased significantly by 1.50 and 1.15 folds (P < 0.001). The odds for heavy drinkers of being ISH, IDH, and SDH increased by 1.38, 2.41, and 2.25 folds, respectively (P < 0.001). For BMI, the odds of being ISH, IDH, and SDH increased in a dose-response manner (P < 0.001). For patients with BMI of [23, 25), [25, 27), [27, 30) and ≥ 30 kg/m(2), the odds (95% confidence interval (CI)) of being SDH increased significantly by 2.28 (2.07-2.50), 3.22 (2.93-3.55), 5.44 (4.93-6.01), and 8.45 (7.31-9.77) folds, respectively. Interaction analysis indicated that BMI and alcohol intake were interactively associated with ISH (P ≤ 0.045) rather than IDH (P ≥ 0.161). Our results demonstrated that BMI and alcohol intake interactively influenced systolic hypertension, especially for overweight and obese patients.
authors.affiliation: Department of Genetics, Beijing Institute of Genomics, Chinese Academy of Sciences, China.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Gu
authors.forename: Yue
authors.initials: Y
authors.lastname: Qi
authors.forename: Mingping
authors.initials: M
authors.lastname: Li
authors.forename: Wenquan
authors.initials: W
authors.lastname: Niu
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000208:ethnology*; D044466:Asian People / Q000706:statistics & numerical data*; D001794:Blood Pressure; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004651:Employment / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006973:Hypertension / Q000145:classification / Q000208:ethnology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology*; D050177:Overweight / Q000208:ethnology; D012307:Risk Factors