title: Effect of BDE-209 on glutathione system in Carassius auratus.
abstract: In this study, the oxidative stress induced by deca-polybromodiphenyl ether (BDE-209) was investigated in livers of Carassius auratus. Six groups of fish were exposed to blank and 0, 0.004, 0.04, 0.4, 4 μM BDE-209 (in 0.1% DMSO) for 1, 4, 7, 10, 13 d, respectively. The following oxidative stress markers were analyzed: reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidases (GPx) and glutathione S-transferases (GSTs). No significant difference was observed in the content of GSH over the whole period of exposure (p > 0.05). Increases in hepatic GR and GPx activities were in concomitant with the decrease in GST activity. GR activity was induced after 1 d exposure, while GPx activity reached maximum at 4 d after exposure to 0.04 μM BDE-209 and GST activity was significantly inhibited at 7-13 d in all the treatment groups (0.004-4 μM group).
authors.affiliation: School of Environmental Science and Public Health, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Zhao
authors.forename: Huanqiang
authors.initials: H
authors.lastname: Liu
authors.forename: Aina
authors.initials: A
authors.lastname: Zhang
authors.forename: Xuedong
authors.initials: X
authors.lastname: Wang
authors.forename: Hongqin
authors.initials: H
authors.lastname: Zhang
authors.forename: Huili
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006054:Goldfish / Q000378:metabolism*; D055768:Halogenated Diphenyl Ethers / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D055768:Halogenated Diphenyl Ethers; D014874:Water Pollutants, Chemical; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione; C010902:decabromobiphenyl ether