title: Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill.
abstract: Using a ball mill, rapid, atom-economic coupling between adenosine-5'-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.
authors.affiliation: School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast, Northern Ireland, UK BT9 5AG.
authors.forename: Francesco
authors.initials: F
authors.lastname: Ravalico
authors.forename: Ivano
authors.initials: I
authors.lastname: Messina
authors.forename: M Victoria
authors.initials: MV
authors.lastname: Berberian
authors.forename: Stuart L
authors.initials: SL
authors.lastname: James
authors.forename: Marie E
authors.initials: ME
authors.lastname: Migaud
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Vyle
mesh_terms: D060326:Chemistry Techniques, Synthetic; D011756:Diphosphates / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010766:Phosphorylation; D013237:Stereoisomerism
chemical_list: D011756:Diphosphates; D009711:Nucleotides