title: Toward an integrated route to the vernonia allenes and related sesquiterpenoids.
abstract: The synthesis of a model endocyclic allene related to the vernonia allenes is described. Fragmentation of a suitable decalin derivative gave the simplified germacrane scaffold. Computational analysis of this and related substrates provides insight into the stereoelectronic requirements of C-C fragmentation. The overall strategy to access these and other sesquiterpenes and the key steps in the present sequence are also discussed.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA.
authors.forename: Da
authors.initials: D
authors.lastname: Xu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Drahl
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Williams