title: Re(CO)(3)(H(2)O)(3)(+) binding to lysozyme: structure and reactivity.
abstract: The reaction of Re(CO)(3)(H(2)O)(3)(+) with hen egg white lysozyme in aqueous solution results in a single covalent adduct. Both NMR spectroscopy and single crystal X-ray diffraction show that the rhenium tricarbonyl cation binds to His15 via replacement of one of the coordinated water molecules. The formation of this adduct does not greatly affect the structure of the protein.
authors.affiliation: Department of Chemistry, University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Binkley
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Leeper
authors.forename: Roger S
authors.initials: RS
authors.lastname: Rowlett
authors.forename: Richard S
authors.initials: RS
authors.lastname: Herrick
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Ziegler
mesh_terms: D001665:Binding Sites; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism*; D018360:Crystallography, X-Ray; D006639:Histidine / Q000737:chemistry; D008958:Models, Molecular; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D012211:Rhenium / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D009942:Organometallic Compounds; D014867:Water; D006639:Histidine; D012211:Rhenium; C421864:hen egg lysozyme; D009113:Muramidase