title: The antidiabetic effect of ginsenoside Rb2 via activation of AMPK.
abstract: Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Kyoung-Tae
authors.initials: KT
authors.lastname: Lee
authors.forename: Tae Woo
authors.initials: TW
authors.lastname: Jung
authors.forename: Hak-Ju
authors.initials: HJ
authors.lastname: Lee
authors.forename: Seul-Gi
authors.initials: SG
authors.lastname: Kim
authors.forename: Yu-Su
authors.initials: YS
authors.lastname: Shin
authors.forename: Wan-Kyunn
authors.initials: WK
authors.lastname: Whang
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D020868:Gene Silencing / Q000187:drug effects; D036145:Ginsenosides / Q000378:metabolism / Q000494:pharmacology*; D005943:Gluconeogenesis / Q000187:drug effects; D005947:Glucose / Q000032:analysis / Q000096:biosynthesis; D022781:Hepatocytes / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects*; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6 / Q000187:drug effects; D012313:RNA / Q000032:analysis; D051381:Rats; D014162:Transfection
chemical_list: D036145:Ginsenosides; D007004:Hypoglycemic Agents; C048026:ginsenoside Rb2; D012313:RNA; D055372:AMP-Activated Protein Kinases; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; C509250:Ptpn6 protein, rat; D005947:Glucose