title: Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats.
abstract: Isolation rearing produces significant behavioral and neurochemical dysregulations in rodents. However, few studies have examined the effects of short-term isolation rearing during puberty compared to chronic social isolation from weaning to adulthood. In this study, we subjected weaning rats to a brief two-week social isolation and then re-socialized them until adulthood. We found that early isolation rearing affected reversal learning without interfering with spatial learning in the Morris water maze. We also found that brain-derived neurotrophic factor (BDNF) protein expression was increased in the medial prefrontal cortex (mPFC) but was decreased in the nucleus accumbens (NAc), CA1 and dentate gyrus of the hippocampus in isolation-reared rats. Together, our findings support the use of adolescent social isolation as a rodent model to study brain and behavior abnormalities induced by early environmental interruptions.
authors.affiliation: Department of Psychology, Peking University, Beijing, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.forename: Weiwen
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Xue
authors.forename: Feng
authors.initials: F
authors.lastname: Shao
authors.forename: Nanxin
authors.initials: N
authors.lastname: Li
mesh_terms: D000375:Aging / Q000523:psychology; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis*; D006624:Hippocampus / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D018782:Maze Learning; D009714:Nucleus Accumbens / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism; D016548:Prosencephalon / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012193:Reversal Learning / Q000502:physiology*; D012931:Social Environment; D012934:Social Isolation
chemical_list: D019208:Brain-Derived Neurotrophic Factor