title: Inflammatory and oxidative stress after surgery for the small area corrections of burn sequelae.
abstract: OBJECTIVE
  To compare vitamin levels, inflammatory and oxidative stress markers before and after skin autograft surgery to correct burn scar areas.
  
  
  METHODS
  This prospective study was conducted with 8 patients with a median age of 28 years (range, 16 to 40 years) that had burn sequelae and were admitted to a Burn Unit for correction of small burn scar areas [3.3 (1.0-5.0) % of the corporal surface]. The volunteers were evaluated before and 48 hours after excision of scar tissue and skin autograft. Routine laboratory data, along with a food questionnaire and anthropometry were collected in the preoperative period. Serum vitamin A, C, E, B(12) and folic acid levels, inflammatory markers (C-protein reactive, alpha-1-acid glycoprotein, ferritin) and oxidative stress markers (reduced glutathione - GSH and Thiobarbituric Acid Reactive Substances - TBARS) were determined at preoperative and postoperative phases. Data were analyzed with two-sample Wilcoxon test.
  
  
  RESULTS
  All volunteers were clinically stable and had adequate nutritional status at admission. After surgery, C-reactive protein serum levels increased [0.4 (0.01-1.0) vs. 2.5 (0.6-4.7) mg/dL, p=0.01] and vitamin A levels decreased [3.4 (2.1-4.2) vs. 2.4 (1.6-4.1) µmol/L, p=0.01]. No changes occurred in other vitamins, ferrritin, alpha-1-acid glycoprotein, GSH and TBARS levels.
  
  
  CONCLUSIONS
  Minimal metabolic changes were produced after skin autograft in small areas of well-nourished patients without active infection or inflammation.
authors.affiliation: Internal Medicine, FMRP-USP, Ribeirao Preto, SP, Brazil.
authors.forename: Paula Pileggi
authors.initials: PP
authors.lastname: Vinha
authors.forename: Alceu Afonso
authors.initials: AA
authors.lastname: Jordão
authors.forename: Jayme Adriano
authors.initials: JA
authors.lastname: Farina
authors.forename: Helio
authors.initials: H
authors.lastname: Vannucchi
authors.forename: Júlio Sérgio
authors.initials: JS
authors.lastname: Marchini
authors.forename: Selma Freire de Carvalho da
authors.initials: SF
authors.lastname: Cunha
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002056:Burns / Q000150:complications* / Q000601:surgery; D002921:Cicatrix / Q000601:surgery*; D003286:Contracture / Q000209:etiology / Q000601:surgery; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D011446:Prospective Studies; D016038:Skin Transplantation / Q000502:physiology*; D018709:Statistics, Nonparametric; D014815:Vitamins / Q000032:analysis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014815:Vitamins