title: Bioinformatics of the TULIP domain superfamily.
abstract: Proteins of the BPI (bactericidal/permeability-increasing protein)-like family contain either one or two tandem copies of a fold that usually provides a tubular cavity for the binding of lipids. Bioinformatic analyses show that, in addition to its known members, which include BPI, LBP [LPS (lipopolysaccharide)-binding protein)], CETP (cholesteryl ester-transfer protein), PLTP (phospholipid-transfer protein) and PLUNC (palate, lung and nasal epithelium clone) protein, this family also includes other, more divergent groups containing hypothetical proteins from fungi, nematodes and deep-branching unicellular eukaryotes. More distantly, BPI-like proteins are related to a family of arthropod proteins that includes hormone-binding proteins (Takeout-like; previously described to adopt a BPI-like fold), allergens and several groups of uncharacterized proteins. At even greater evolutionary distance, BPI-like proteins are homologous with the SMP (synaptotagmin-like, mitochondrial and lipid-binding protein) domains, which are found in proteins associated with eukaryotic membrane processes. In particular, SMP domain-containing proteins of yeast form the ERMES [ER (endoplasmic reticulum)-mitochondria encounter structure], required for efficient phospholipid exchange between these organelles. This suggests that SMP domains themselves bind lipids and mediate their exchange between heterologous membranes. The most distant group of homologues we detected consists of uncharacterized animal proteins annotated as TM (transmembrane) 24. We propose to group these families together into one superfamily that we term as the TULIP (tubular lipid-binding) domain superfamily.
authors.affiliation: Department of Protein Evolution, Max-Planck-Institute for Developmental Biology, Spemannstrasse 35, 72076 Tübingen, Germany.
authors.forename: Klaus O
authors.initials: KO
authors.lastname: Kopec
authors.forename: Vikram
authors.initials: V
authors.lastname: Alva
authors.forename: Andrei N
authors.initials: AN
authors.lastname: Lupas
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D016000:Cluster Analysis; D019295:Computational Biology; D019143:Evolution, Molecular; D006801:Humans; D008055:Lipids / Q000737:chemistry; D017434:Protein Structure, Tertiary / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D002352:Carrier Proteins; D008055:Lipids