title: Effects of coronary angiography and femoral arterial access on endothelial functions.
abstract: BACKGROUND
  Impairment of endothelial function is an independent predictor of coronary events. The aim of this study was to clarify the influence of arterial access and coronary angiography on endothelial function.
  
  
  METHODS
  Eighteen patients with stable angina pectoris who underwent coronary angiography were included in this study. Brachial artery flow-mediated dilatation of patients was measured before angiography, after femoral arterial sheath insertion, and after coronary angiography.
  
  
  RESULTS
  Of 18 patients, 11 had angiographically apparent atherosclerosis. Flow-mediated dilatation after femoral arterial sheath insertion (mean ± SD, 6.62% ± 3.87%) was found to be significantly lower than either before (10.62% ± 5.18%) or after coronary angiography (11.66% ± 5.30%; P = 0.007 and P = 0.001, respectively). Basal and postangiographic flow-mediated dilatation values were similar. Flow-mediated dilatation significantly decreased after sheath insertion in the group with angiographically normal coronary arteries (14.47% ± 4.34% vs 5.98 ± 4.00%, respectively; P = 0.006), whereas the difference was not significant in patients with CAD (8.17% ± 4.16% vs 7.03% ± 3.92%, respectively).
  
  
  CONCLUSIONS
  Coronary angiography did not result in endothelial vasomotor dysfunction. Femoral arterial sheath insertion during coronary angiography was associated with a short-lived endothelial dysfunction. Larger studies are needed to interpret the effect of coronary atherosclerosis on attenuation of endothelial response against arterial wall injury.
authors.affiliation: Department of Cardiology, Kırıkkale University School of Medicine, Kırıkkale, Turkey. mtulmac@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Tulmaç
authors.forename: Nurtaç
authors.initials: N
authors.lastname: Ozer
authors.forename: Vedat
authors.initials: V
authors.lastname: Simşek
authors.forename: Mehmet Tolga
authors.initials: MT
authors.lastname: Doğru
authors.forename: Haksun
authors.initials: H
authors.lastname: Ebinç
mesh_terms: D000787:Angina Pectoris / Q000175:diagnosis; D000792:Angiography / Q000379:methods; D050197:Atherosclerosis / Q000175:diagnosis / Q000473:pathology; D001916:Brachial Artery / Q000473:pathology; D002309:Cardiology / Q000379:methods; D003287:Contrast Media / Q000494:pharmacology; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease; D003326:Coronary Circulation; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D005263:Femoral Artery / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation
chemical_list: D003287:Contrast Media