title: Accelerated hydrolysis of α-halo and α-cyano pyridinium relative to uracil derivatives: a model for ODCase-catalyzed hydrolysis of 6-cyanoUMP.
abstract: α-Halo and α-cyano pyridiniums were found to undergo facile hydrolysis, in contrast to the sluggish reactions of corresponding uracils. The greatly enhanced rates found with pyridinium compounds have indicated a possible source of the rate acceleration seen in the hydrolysis of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase.
authors.affiliation: Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 USA.
authors.forename: Sha
authors.initials: S
authors.lastname: Huang
authors.forename: Freeman M
authors.initials: FM
authors.lastname: Wong
authors.forename: George T
authors.initials: GT
authors.lastname: Gassner
authors.forename: Weiming
authors.initials: W
authors.lastname: Wu