title: Monovalent rotavirus vaccine provides protection against an emerging fully heterotypic G9P[4] rotavirus strain in Mexico.
abstract: After the introduction of monovalent rotavirus vaccine (RV1) in Mexico in 2006-2007, diarrhea mortality and morbidity declined substantially among Mexican children under 5 years of age. In January 2010, surveillance identified the emergence of a novel G9P[4] rotavirus strain nationwide. We conducted a case-control study to assess the field effectiveness of RV1 against severe rotavirus gastroenteritis caused by this unusual strain and to determine whether the G9P[4] emergence was related to vaccine failure or failure to vaccinate. RV1 was 94% effective (95% confidence interval, 16%-100%) against G9P[4] rotavirus-related hospitalization, indicating that its emergence was likely unrelated to vaccine pressure.
authors.affiliation: Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. cyen@cdc.go
authors.forename: Catherine
authors.initials: C
authors.lastname: Yen
authors.forename: Jesùs Reyna
authors.initials: JR
authors.lastname: Figueroa
authors.forename: Edgar Sánchez
authors.initials: ES
authors.lastname: Uribe
authors.forename: Luz Del
authors.initials: LD
authors.lastname: Carmen-Hernández
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Tate
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
authors.forename: Manish M
authors.initials: MM
authors.lastname: Patel
authors.forename: Vesta
authors.initials: V
authors.lastname: Richardson López-Collado
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005759:Gastroenteritis / Q000517:prevention & control* / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D008800:Mexico / Q000453:epidemiology; D012401:Rotavirus; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D022243:Rotavirus Vaccines
chemical_list: D022243:Rotavirus Vaccines