title: Myocardial contractility and relaxation after deep hypothermic circulatory arrest in a neonatal piglet model.
abstract: Cooling before circulatory arrest or ischemic arrest has been reported to influence myocardial performance in isolated neonatal hearts. The aim of the present study was to analyze indices of myocardial contractility and relaxation in an in vivo neonatal model after deep hypothermic circulatory arrest (DHCA). DHCA (18°C; DHCA group; n = 8) or mild hypothermic cardiopulmonary bypass ([MH-CPB] 32°C; MH-CPB group; n = 10) was applied in newborn piglets. After reperfusion (60 and 120 min), left ventricular dP/dt(max) increased in DHCA and MH-CPB, while-dP/dt(max) decreased slightly in DHCA and increased in MH-CPB. Nevertheless, the differences between the two groups did not reach statistical significance. In conclusion, left ventricular contractility remained stable after reperfusion following DHCA, to some degree at the expense of the diastolic function.
authors.affiliation: Department for Thoracic, Cardiac, and Vascular Surgery, University of Goettingen, Goettingen, Germany. theodor.tirilomis@med.uni-goettingen.de
authors.forename: Theodor
authors.initials: T
authors.lastname: Tirilomis
authors.forename: Aron-Frederik
authors.initials: AF
authors.lastname: Popov
authors.forename: Oliver J
authors.initials: OJ
authors.lastname: Liakopoulos
authors.forename: Jan D
authors.initials: JD
authors.lastname: Schmitto
authors.forename: Marc
authors.initials: M
authors.lastname: Bensch
authors.forename: Katja
authors.initials: K
authors.lastname: Steinke
authors.forename: K Oguz
authors.initials: KO
authors.lastname: Coskun
authors.forename: Friedrich A
authors.initials: FA
authors.lastname: Schoendube
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002315:Cardiopulmonary Bypass / Q000379:methods; D050792:Circulatory Arrest, Deep Hypothermia Induced / Q000009:adverse effects*; D004195:Disease Models, Animal; D006324:Heart Arrest, Induced / Q000009:adverse effects*; D007036:Hypothermia, Induced / Q000009:adverse effects*; D009200:Myocardial Contraction / Q000502:physiology*; D015428:Myocardial Reperfusion Injury / Q000209:etiology* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D013552:Swine / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology