title: Chiral separation of basic compounds on a cellulose 3,5-dimethylphenylcarbamate-coated zirconia monolithin basic eluents by capillary electrochromatography.
abstract: Porous zirconia monolith (ZM) modified with cellulose 3,5-dimethylphenylcarbamate (CDMPC) was used as chiral stationary phase to separate basic chiral compounds in capillary electrochromatography. The electroosmotic flow behavior of bare and CDMPC-modified zirconia monolithic (CDMPC-ZM) column was studied in ACN/phosphate buffer eluents of pH ranging from 2 to 12. The CDMPC-ZM column was evaluated by investigating the influences of pH, the type and composition of organic modifier of the eluent on enantioseparation. CEC separations at pH 9 provided the best resolutions for the analytes studied, which are better than those observed on CDMPC-modified silica monolithic columns under similar chromatographic conditions. No appreciable decline in retention and resolution factors after over 200 injections, and run-to-run and day-to-day repeatabilities of the column of less than 3% indicate the stability of the zirconia monolithic column in basic media.
authors.affiliation: Department of Chemistry, Yeungnam University, Gyeongsan 712-749, South Korea.
authors.forename: Avvaru Praveen
authors.initials: AP
authors.lastname: Kumar
authors.forename: Jung Hag
authors.initials: JH
authors.lastname: Park
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D053801:Capillary Electrochromatography / Q000379:methods*; D002219:Carbamates / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009930:Organic Chemicals / Q000737:chemistry; D015203:Reproducibility of Results; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000097:Acetonitriles; D002219:Carbamates; D009930:Organic Chemicals; C509199:cellulose 3,5-dimethylphenylcarbamate; D002482:Cellulose; D015040:Zirconium; C028541:zirconium oxide; C032159:acetonitrile