title: Infantile choriocarcinoma in a neonate with massive liver involvement cured with chemotherapy and liver transplant.
abstract: A 6-week-old boy presented with fever, pallor, and hepatomegaly. Ultrasound showed a huge midline abdominal mass. β-human chorionic gonadotropin was markedly elevated, suggesting a diagnosis of infantile choriocarcinoma of the liver. A biopsy confirmed the diagnosis. The patient received 6 cycles of bleomycin, cisplatin, and etoposide with significant decrease in tumor size. However, the tumor remained unresectable. A donor liver became available, and the infant underwent successful liver transplantation. He received 2 posttransplant cycles of moderate dose of methotrexate. This case shows the use of liver transplantation in cases of infantile choriocarcinoma of the liver where the tumor remains unresectable despite chemotherapy.
authors.affiliation: Alfred I. duPont Hospital for Children, Wilmington, DE, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Hanson
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Walter
authors.forename: Stephen
authors.initials: S
authors.lastname: Dunn
authors.forename: David W
authors.initials: DW
authors.lastname: Rittenhouse
authors.forename: Gregory
authors.initials: G
authors.lastname: Griffin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002648:Child; D002822:Choriocarcinoma / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D013736:Testicular Neoplasms / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin; D008727:Methotrexate