title: Is there a BP benefit of changing the time of aspirin administration in treated hypertensive patients?
abstract: METHODS
  The effects of aspirin on blood pressure (BP) are controversial and a chronopharmacological effect of aspirin on 24-hour BP was reported recently in otherwise untreated hypertensive patients. The study was designed to test the timing effect of aspirin dosing on 24-hour BP in treated hypertensive patients routinely taking aspirin for cardiovascular prevention.
  
  
  RESULTS
  Seventy-five patients were randomized into two groups. One group was to receive aspirin in the evening then in the morning for 1 month and the other group in the morning then in the evening, following a cross-over design. The principal assessment criterion was 24-hour systolic BP (SBP) measured by 24-hour ambulatory BP monitoring (ABPM). Patients were aged 65 ± 9 years and had been hypertensive for 12 ± 10 years. They were all taking a mean of 2.8 antihypertensive drugs and did not modify their treatment throughout the study. Of the included subjects, 70% were men and 33% were diabetics. Mean 24-hour SBP values were clinically equivalent and were not statistically different, depending on whether the aspirin was taking in the morning or evening (128.3 ± 1.4 vs. 128.3 ± 1.4 mmHg, respectively). Neither was there any significant difference in diurnal and nocturnal SBP or in 24-hour, diurnal, and nocturnal diastolic BP (DBP).
  
  
  CONCLUSIONS
  It does not appear useful to advise patients with long-standing hypertension to modify timing of aspirin intake in order to reduce BP values.
authors.affiliation: Club des Jeunes Hypertensiologues, Haguenau, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Dimitrov
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Baguet
authors.forename: Carine
authors.initials: C
authors.lastname: Hottelart
authors.forename: Philippe
authors.initials: P
authors.lastname: Marboeuf
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Tartiere
authors.forename: Michel
authors.initials: M
authors.lastname: Ducher
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Fauvel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005602:France; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin