title: Primary leiomyosarcoma of the seminal vesicle: case report and review of the literature.
abstract: BACKGROUND
  Primary leiomyosarcoma of the seminal vesicle is exceedingly rare.
  
  
  METHODS
  We report a case of a 59-year-old man with tumour detected by rectal symptoms and ultrasonography. Computed tomography and magnetic resonance imaging suggested an origin in the right seminal vesicle. Transperineal biopsy of the tumour revealed leiomyosarcoma. A radical vesiculo-prostactectomy with bilateral pelvic lymphadenectomy was performed. Pathological examination showed a grade 2 leiomyosarcoma of the seminal vesicle. The patient received adjuvant radiotherapy. He developed distant metastases 29 months after diagnosis, and received chemotherapy. Metastatic disease was controlled by second-line gemcitabine-docetaxel combination. Fifty-one months after diagnosis of the primary tumour, and 22 months after the first metastases, the patient is alive with excellent performance status, and multiple asymptomatic stable lung and liver lesions.
  
  
  CONCLUSIONS
  We report the eighth case of primary leiomyosarcoma of the seminal vesicle and the first one with a so long follow-up.
authors.affiliation: Department of Radiotherapy, Institut Paoli-Calmettes, 27 bd Leï Roure, 13009, Marseille, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Cauvin
authors.forename: Laurence
authors.initials: L
authors.lastname: Moureau-Zabotto
authors.forename: Bruno
authors.initials: B
authors.lastname: Chetaille
authors.forename: Werner
authors.initials: W
authors.lastname: Hilgers
authors.forename: Yves
authors.initials: Y
authors.lastname: Denoux
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Jacquemier
authors.forename: Jérôme
authors.initials: J
authors.lastname: Guiramand
authors.forename: Anthony
authors.initials: A
authors.lastname: Sarran
authors.forename: François
authors.initials: F
authors.lastname: Bertucci
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077143:Docetaxel; D005834:Genital Neoplasms, Male / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000628:therapy; D008113:Liver Neoplasms / Q000517:prevention & control / Q000556:secondary; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D018714:Radiotherapy, Adjuvant; D012669:Seminal Vesicles / Q000473:pathology*; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D000093542:Gemcitabine