title: [Exclusive radiotherapy and concurrent endocrine therapy for the management of elderly breast cancer patients: case study and review of hypofractionated schemes].
abstract: Normofractionated radiotherapy is standard for adjuvant management of patients treated with breast conservative surgery for breast cancer. However, many elderly patients are not eligible to such strategy, either because of concurrent diseases, or because the tumor is inoperable. Several protocols of exclusive radiotherapy have been reported in the literature, frequently using hypofractionated radiotherapy and endocrine therapy. We report a case of a patient treated with exclusive endocrine and radiotherapy and address the state of the art on hypofractionated schemes for the management of elderly breast cancer patients. While hypofractionated radiotherapy does not compromise the oncologic or cosmetic outcome, there is no prospective data that assesses the place of radiotherapy for the exclusive treatment of elderly patients. This strategy should be further assessed in clinical randomized trial.
authors.affiliation: Département de Radiothérapie, Institut de Cancérologie de la Loire, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Auberdiac
authors.forename: C
authors.initials: C
authors.lastname: Chargari
authors.forename: L
authors.initials: L
authors.lastname: Cartier
authors.forename: A
authors.initials: A
authors.lastname: Mélis
authors.forename: N
authors.initials: N
authors.lastname: Malkoun
authors.forename: C
authors.initials: C
authors.lastname: Chauleur
authors.forename: J-P
authors.initials: JP
authors.lastname: Jacquin
authors.forename: G
authors.initials: G
authors.lastname: de Laroche
authors.forename: N
authors.initials: N
authors.lastname: Magné
mesh_terms: D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans
chemical_list: D006728:Hormones