title: Association of Fcγ receptor IIIA variant with a subset of anti-topoisomerase I-positive patients in systemic sclerosis: a descriptive pilot study.
abstract: Hypothesizing a pathophysiological role of anti-topoisomerase I antibodies (anti-topo I) through autoantibody-dependent cell-mediated cytotoxicity (ADCC) and cytotoxic effectors expressing receptors for the Fc portion of IgG in systemic sclerosis (SSc), 267 SSc patients (56 with anti-topo I and 102 with anti-centromere antibodies (ACA)) were genotyped for the functional FCGR3A-V158F polymorphism. A descriptive analysis of patients according to their clinical and immunological status and FCGR3A-158 V/F genotypes was performed using multiple correspondence analysis. This descriptive analysis revealed an association between the FCGR3A-158 VV genotype and the presence of anti-topo I. By contrast, no relationship was found between FCGR3A polymorphism and the presence of ACA. SSc patients with anti-topo I appear to be more frequently homozygous for the high-affinity FcγRIIIA-coding allele, suggesting that some autoantibodies may be pathogenic through ADCC.
authors.affiliation: Service de Médecine Interne et Vasculaire B, CHRU de Tours, France, Tours, France. magnant@med.univ-tours.fr
authors.forename: J
authors.initials: J
authors.lastname: Magnant
authors.forename: M
authors.initials: M
authors.lastname: Ohresser
authors.forename: Y
authors.initials: Y
authors.lastname: Allanore
authors.forename: M
authors.initials: M
authors.lastname: de Monte
authors.forename: M
authors.initials: M
authors.lastname: Lafosse-Marin
authors.forename: D
authors.initials: D
authors.lastname: Degenne
authors.forename: J L
authors.initials: JL
authors.lastname: Guilmot
authors.forename: H
authors.initials: H
authors.lastname: Watier
authors.forename: E
authors.initials: E
authors.lastname: Diot
mesh_terms: D000328:Adult; D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D002503:Centromere / Q000276:immunology; D004264:DNA Topoisomerases, Type I / Q000276:immunology*; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D017452:Receptors, IgG / Q000235:genetics* / Q000276:immunology; D012595:Scleroderma, Systemic / Q000235:genetics* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D017452:Receptors, IgG; D004264:DNA Topoisomerases, Type I