title: [Pharmacological effects of remaxol on endotoxicosis of peritonitis genesis].
abstract: It is found that the drug remaxol, which possesses antioxidant and antihypoxant properties, is also highly effective in correction of metabolism disorders in the kidneys with peritoneal endotoxicosis. The high neuroprotective effect of remaxol is related to its ability to correct the lipid metabolism violated by hypoxia phenomena in tissues, to decrease peroxidation of lipids and activity of phospholipase A2, and to recover intrinsic antioxidant potential of cellular structures of the kidney.
authors.forename: A P
authors.initials: AP
authors.lastname: Vlasov
authors.forename: O V
authors.initials: OV
authors.lastname: Loginova
authors.forename: V V
authors.initials: VV
authors.lastname: Vasil'ev
authors.forename: T I
authors.initials: TI
authors.lastname: Vlasova
authors.forename: V A
authors.initials: VA
authors.lastname: Shibitov
authors.forename: T N
authors.initials: TN
authors.lastname: Kazaeva
authors.forename: M V
authors.initials: MV
authors.lastname: Matveeva
mesh_terms: D000818:Animals; D000975:Antioxidants; D002374:Catalase / Q000032:analysis; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D000860:Hypoxia / Q000517:prevention & control; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D007677:Kidney Function Tests; D050356:Lipid Metabolism / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000032:analysis; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D010537:Peritoneum / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism* / Q000382:microbiology / Q000503:physiopathology; D064801:Phospholipase A2 Inhibitors; D054467:Phospholipases A2 / Q000378:metabolism; D013386:Succinates / Q000008:administration & dosage; D013482:Superoxide Dismutase / Q000032:analysis
chemical_list: D000975:Antioxidants; D008055:Lipids; D064801:Phospholipase A2 Inhibitors; C555877:Remaxol; D013386:Succinates; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D054467:Phospholipases A2