title: Discrepancy of pre- and postoperative grades of patients with endometrial carcinoma.
abstract: OBJECTIVE
  To investigate the diagnostic accuracy of endometrial curettage in patients with endometrial carcinoma. In this retrospective study, pre- and postoperative histopathologic findings of patients with endometrial cancer were investigated.
  
  
  METHODS
  168 patients with the final diagnosis of endometrial cancer were enrolled in the study. Pre- and postoperative histopathologic diagnoses and grades (according to the 1988 FIGO classification) of the patients were compared retrospectively.
  
  
  RESULTS
  22 patients were diagnosed as having endometrial hyperplasia and the remaining 136 patients had endometrial carcinoma preoperatively. Overall discrepancy rate of grades was 39% (31% upgrade, 8% downgrade; p < 0.05). There was also 9% discrepancy between the pre- and postoperative histopathological types.
  
  
  CONCLUSIONS
  It has been suggested that since endometrial cancer patients with low grades according to the preoperative pathologic diagnosis have a potential to upgrade, the management of these patients if myometrial invasion is less than one-half thickness, simply by hysterectomy plus bilateral salpingo-oophorectomy (without lymph node sampling), might actually miss some patients who actually deserve surgical staging. Further studies are needed to draw a sufficient conclusion.
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Hospital, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Karateke
authors.forename: N
authors.initials: N
authors.lastname: Tug
authors.forename: C
authors.initials: C
authors.lastname: Cam
authors.forename: S
authors.initials: S
authors.lastname: Selcuk
authors.forename: M R
authors.initials: MR
authors.lastname: Asoglu
authors.forename: S
authors.initials: S
authors.lastname: Cakir
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D003475:Curettage; D004714:Endometrial Hyperplasia / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric