title: High throughput platforms for structural genomics of integral membrane proteins.
abstract: Structural genomics approaches on integral membrane proteins have been postulated for over a decade, yet specific efforts are lagging years behind their soluble counterparts. Indeed, high throughput methodologies for production and characterization of prokaryotic integral membrane proteins are only now emerging, while large-scale efforts for eukaryotic ones are still in their infancy. Presented here is a review of recent literature on actively ongoing structural genomics of membrane protein initiatives, with a focus on those aimed at implementing interesting techniques aimed at increasing our rate of success for this class of macromolecules.
authors.affiliation: Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
authors.forename: Filippo
authors.initials: F
authors.lastname: Mancia
authors.forename: James
authors.initials: J
authors.lastname: Love
mesh_terms: D000818:Animals; D004926:Escherichia coli / Q000235:genetics; D023281:Genomics / Q000379:methods*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism
chemical_list: D008565:Membrane Proteins