title: Effects of gene-environmental interaction on noise-induced hearing threshold levels for high frequencies (HTLHF).
abstract: In this study we assessed the interaction between glutathione S-transferase (GST) genetic polymorphisms and noise exposures, with regard to their effect on the hearing threshold levels for high frequencies (HTLHF). Research participants comprised 347 male workers, and each participant's cumulative noise exposure was determined using a job-exposure matrix. Approximately 64.6% of the participants' exposure in L(eq-8 h) was above 90 dBA. The mean HTLHF was 32.1 dB. A significant dose-response relationship was found between noise exposure and HTLHF. We further converted the estimated total noise exposure level over each participant's job history to a noise exposure level that corresponded to a 40-year exposure (L(eq-40y)). After we had adjusted the results for age, we found that workers carrying GSTM1 null, GSTT1 null, and GSTP1 Ile(105)/Ile(105) genotypes were susceptible to the HTLHF when their L(eq-40y) were above 90 dBA. Therefore, GST genetic polymorphisms might affect HTLHF only when workers are exposed to high noise levels.
authors.affiliation: Department of Otolaryngology, Tainan Hospital, West Central District, Tainan City 700, Taiwan.
authors.forename: Cheng-Yu
authors.initials: CY
authors.lastname: Lin
authors.forename: Tung-Sheng
authors.initials: TS
authors.lastname: Shih
authors.forename: Yue-Liang Leon
authors.initials: YL
authors.lastname: Guo
authors.forename: Jiunn-Liang
authors.initials: JL
authors.lastname: Wu
authors.forename: Yih-Min
authors.initials: YM
authors.lastname: Sun
authors.forename: Perng-Jy
authors.initials: PJ
authors.lastname: Tsai
mesh_terms: D000328:Adult; D000818:Animals; D004777:Environment; D059647:Gene-Environment Interaction; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006317:Hearing Loss, Noise-Induced / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D006320:Hearing Tests; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009623:Noise, Occupational / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species / Q000009:adverse effects / Q000378:metabolism; D013016:Sound / Q000009:adverse effects
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D007527:Isoenzymes; D017382:Reactive Oxygen Species; C413545:glutathione S-transferase T1