title: Roux-en-Y gastric bypass and inflammatory activity of the adipose tissue.
abstract: OBJECTIVE
  To evaluate the oxidative stress and inflammatory markers in obese patients before and after Roux-en-Y vertical banded gastroplasty.
  
  
  METHODS
  We studied 20 class III obese patients undergoing Roux-en-Y vertical banded gastroplasty, seven men and 13 women, mean age 39 years, and 20 non-obese subjects, nine males and 11 females, mean age 38 years. We determined the plasma levels of malondialdehyde, stress an index, total antioxidant capacity, catalase, reduced and oxidized glutathione and inflammatory markers (C reactive protein and á-1 acid glycoprotein). In the obese group, these parameters were determined before and 2, 6 and 12 months after gastroplasty.
  
  
  RESULTS
  Preoperatively, the obese group showed elevated levels of inflammatory markers of oxidative stress (malondialdehyde levels and stress index) and lower levels of indicators of antioxidant defense compared to the control group. Weight loss was accompanied by gradual reduction in the levels of malondialdehyde and stress index. We found an increased concentration of reduced glutathione and total antioxidant status and reduced levels of inflammatory markers.
  
  
  CONCLUSIONS
  Weight loss improves the inflammatory state and oxidative stress levels.
authors.affiliation: Department of Surgery, State University of Londrina, Paraná-PR, BR. valezi@sercomtel.com.br
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Valezi
authors.forename: Edilson João
authors.initials: EJ
authors.lastname: Cabrera
authors.forename: Vinicius Daher Alvares
authors.initials: VD
authors.lastname: Delfino
authors.forename: Decio Sabbatini
authors.initials: DS
authors.lastname: Barbosa
authors.forename: Jorge
authors.initials: J
authors.lastname: Mali Junior
authors.forename: Mariano de Almeida
authors.initials: Mde A
authors.lastname: Menezes
mesh_terms: D000273:Adipose Tissue / Q000276:immunology* / Q000378:metabolism*; D000328:Adult; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D007249:Inflammation; D008297:Male; D009765:Obesity / Q000601:surgery; D018384:Oxidative Stress