title: Synthesis and antimicrobial activity of new 1-[(tetrazol-5-yl)methyl] indole derivatives, their 1,2,4-triazole thioglycosides and acyclic analogs.
abstract: New 1-[(tetrazol-5-yl)methyl]indole derivatives, their acyclic nucleoside analogs and the corresponding glycoside derivatives were synthesized. Furthermore, the [)(1,2,4-triazol-3-yl)methyl])-2H-tetrazole derivative as well as the corresponding thioglucoside were prepared. The synthesized compounds were tested for their antimicrobial activity against Aspergillus Niger, Penicillium sp, Candida albican, Bacillus subtilis, Streptococcus lacti, Escherichia coli, Pseudomonas sp., and streptomyces sp. Compounds 3, 5 and 19b exhibited potent antibacterial activity and compounds 4, 5 and 10 exhibited high activities against the tested fungi compared with fusidic acid.
authors.affiliation: Photochemistry Department, National Research Center, El-Dokki, Cairo 72427, Egypt. waelshendy@gmail.com
authors.forename: Weal A
authors.initials: WA
authors.lastname: El-Sayed
authors.forename: Randa E
authors.initials: RE
authors.lastname: Abdel Megeid
authors.forename: Hebat-Allah S
authors.initials: HA
authors.lastname: Abbas
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013865:Thioglycosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles
chemical_list: C569592:1-(1-(2H-tetrazol-5-ylmethyl)-1H-indol-3-yl)ethanone; D000890:Anti-Infective Agents; D007211:Indoles; D013777:Tetrazoles; D013865:Thioglycosides; D014230:Triazoles; C569593:ethyl(5-((3-acetyl-1H-indol-1-yl)methyl)-2H-tetrazol-2-yl)acetate; C045575:1,2,4-triazole