title: Synthesis, spectroscopy and antibacterial activity of supermolecular compounds of organotitanium substituted heteropolytungstates containing 8-quinolinol.
abstract: Parent compounds of cyclopentadienyltitanium substituted heteropolytungstates with Keggin structure, An[(CpTi)XW11O39] xH2O (A=Me4N, K; X=P, Si, Co; Cp=eta5-C5H5) were synthesized in aqueous phase. By allowing parent heteropoly compounds to react with protonated 8-quinolinol, the title supermolecular compounds (C9H8NO)mAn[(CpTi)XW11O39] xH2O (A=Me4N, H; X=P, Si, Co) were synthesized. The title compounds were characterized by means of elementary analysis, IR, UV, 1H NMR, XRD and TG-DSC. The results indicate that the title compounds are new heteropoly compounds, and there is a charge transfer interaction between the organic cation and heteropoly anion. The results obtained from thermal analysis show that QCpTiPW, QCpTiSiW and QCpTiCoW begin to decompose at 212.4, 194.2 and 171.2 degrees C, respectively. The results obtained from antibacterial test reveal that QCpTiSiW has the best antibacterial activity, and the MIC values of QCpTiSiW against Escherichia coli and Staphylococcus aurous are 64.0 and 0.500 microg mL(-1), respectively.
authors.affiliation: State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing 100081, China. cgfeng@cast.org.cn
authors.forename: Chang-gen
authors.initials: CG
authors.lastname: Feng
authors.forename: Yu-di
authors.initials: YD
authors.lastname: Xiong
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D015125:Oxyquinoline / Q000138:chemical synthesis / Q000737:chemistry*; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects; D017973:Tungsten Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D017973:Tungsten Compounds; D015125:Oxyquinoline; C045951:tungstate