title: [Pathogenetic characteristics of generalized parodontitis in elderly patients].
abstract: Chronic periodontit inflammation in old-aged patients was found to be accompanied by imbalance of complement system; sIgA, IgA, IgG and IgM hyperproduction; increased concentrations of IL-8, IL-1alpha and decreased level of IL-4; abrogated NO and its derivatives concentration; increased anti-HSP-70 and homocystein levels in blood and saliva. The obtained results justify the necessity to use in therapy of chronic parodontit inflammation the immunocorrection, antioxidant and bioregulatory therapy, which normalize the cells function.
authors.forename: M S
authors.initials: MS
authors.lastname: Malezhik
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Pinelis
authors.forename: L P
authors.initials: LP
authors.lastname: Malezhik
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood* / Q000276:immunology; D000906:Antibodies / Q000097:blood; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood* / Q000150:complications / Q000276:immunology; D003165:Complement System Proteins / Q000032:analysis; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications / Q000276:immunology; D009569:Nitric Oxide / Q000097:blood; D012463:Saliva / Q000276:immunology
chemical_list: D000906:Antibodies; D018840:HSP70 Heat-Shock Proteins; D007136:Immunoglobulins; D007378:Interleukins; D009569:Nitric Oxide; D003165:Complement System Proteins