title: Inverse correlation between plasma Beta-carotene and interleukin-6 in patients with advanced coronary artery disease.
abstract: The interrelationships between plasma beta-carotene, alpha-tocopherol, and the level of systemic inflammation and oxidative stress were investigated in patients with advanced coronary artery disease (CAD). Plasma beta-carotene, alpha-tocopherol, malondialdehyde, free radicals, interleukin-6, high sensitive C-reactive protein levels, and other risk factors of CAD were determined in a group of patients with advanced CAD [significant stenosis according to coronarographic examination (n=91) and a control group of examined patients with coronary arteries with no stenosis (n=49)]. Between-group differences in continuous variables were analyzed with the Hotelling T2-test (software NCSS2000), analyses of correlation matrix with the software STATISTICA. Advanced CAD coincided with significantly lower plasma concentrations of high-density lipoprotein (HDL)-cholesterol and beta-carotene as well as with elevated levels of all inflammatory markers, but only with mild increase of oxidative stress. Beta-carotene significantly inversely correlated with interleukin-6. This inverse correlation could suggest potential protective effect of beta-carotene on atherosclerosis due to the inhibition of inflammatory processes.
authors.affiliation: Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, and Department of Clinical Biochemistryand Diagnostics, Regional Hospital of Pardubice, Pardubice, Czech Republic. vladimira.muzakova@upce.cz
authors.forename: Vladimíra
authors.initials: V
authors.lastname: Muzáková
authors.forename: Roman
authors.initials: R
authors.lastname: Kand'ár
authors.forename: Milan
authors.initials: M
authors.lastname: Meloun
authors.forename: Jirí
authors.initials: J
authors.lastname: Skalický
authors.forename: Karel
authors.initials: K
authors.lastname: Královec
authors.forename: Pavla
authors.initials: P
authors.lastname: Záková
authors.forename: Petr
authors.initials: P
authors.lastname: Vojtísek
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D011795:Surveys and Questionnaires; D024502:alpha-Tocopherol / Q000097:blood; D019207:beta Carotene / Q000097:blood*
chemical_list: D015850:Interleukin-6; D019207:beta Carotene; D008315:Malondialdehyde; D002097:C-Reactive Protein; D002784:Cholesterol; D024502:alpha-Tocopherol