title: Nitrogen kinetic isotope effects for the monoamine oxidase B-catalyzed oxidation of benzylamine and (1,1-(2)H2)benzylamine: nitrogen rehybridization and CH bond cleavage are not concerted.
abstract: Nitrogen kinetic isotope effects for the oxidation of benzylamine and (1,1-(2)H(2))benzylamine by recombinant human monoamine oxidase B show that cleavage of the CH bond is not concerted with rehybridization of the nitrogen atom.
authors.affiliation: Department of Biochemistry and Organic Chemistry, Uppsala University, P.O. Box 576, SE-75123 Uppsala, Sweden.
authors.forename: Susanna
authors.initials: S
authors.lastname: MacMillar
authors.forename: Dale E
authors.initials: DE
authors.lastname: Edmondson
authors.forename: Olle
authors.initials: O
authors.lastname: Matsson
mesh_terms: D001596:Benzylamines / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008995:Monoamine Oxidase / Q000378:metabolism*; D009587:Nitrogen Isotopes / Q000378:metabolism; D010084:Oxidation-Reduction; D011994:Recombinant Proteins / Q000378:metabolism
chemical_list: D001596:Benzylamines; D009587:Nitrogen Isotopes; D011994:Recombinant Proteins; D008995:Monoamine Oxidase