title: Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting.
abstract: The function of cell-specific ligands on gold nanoparticles can be selectively gated by the action of co-grafted thermosensitive polymers. Below the LCST the responsive chain-extended polymers prevent cell-surface receptors from accessing the affinity ligands while above the LCST, the polymers collapse exposing the ligands and allowing binding to receptors, which in turn promotes cell internalisation.
authors.affiliation: Department of Pharmaceutical Sciences, University of Padua, Padova, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Mastrotto
authors.forename: Paolo
authors.initials: P
authors.lastname: Caliceti
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Amendola
authors.forename: Sara
authors.initials: S
authors.lastname: Bersani
authors.forename: Johannes Pall
authors.initials: JP
authors.lastname: Magnusson
authors.forename: Moreno
authors.initials: M
authors.lastname: Meneghetti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mantovani
authors.forename: Cameron
authors.initials: C
authors.lastname: Alexander
authors.forename: Stefano
authors.initials: S
authors.lastname: Salmaso
mesh_terms: D001692:Biological Transport; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007624:KB Cells; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D008024:Ligands; D011108:Polymers; D006046:Gold