title: [Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats].
abstract: The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted. It is shown that introduction of short peptides promotes a survival rate of the animals that have modeled occlusion of carotid arteries. Under Pinealon before occlusion of carotid arteries, behavioral dream has been increased and a position-finding behavior, a motivational behavior and a motor performance have been reduced. The rats that were introduced Cortexin before carotid arteries occlusion demonstrated the raise of behavioral dream time. At introduction of Pinealon activity of caspase-3 moderately raises in false-operated animals and in a model of occlusion of carotid arteries.
authors.forename: A M
authors.initials: AM
authors.lastname: Mendzheritskiĭ
authors.forename: G V
authors.initials: GV
authors.lastname: Karantysh
authors.forename: K O
authors.initials: KO
authors.lastname: Ivonina
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000201:enzymology; D016893:Carotid Stenosis / Q000201:enzymology / Q000503:physiopathology / Q000517:prevention & control*; D053148:Caspase 3 / Q000378:metabolism*; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D016019:Survival Analysis
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; D010455:Peptides; C570174:pinealon; C056590:cortexin; C505410:Casp3 protein, rat; D053148:Caspase 3