title: Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration.
abstract: BACKGROUND
  We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members.
  
  
  METHODS
  We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls.
  
  
  RESULTS
  Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P<0.0001, 0.021, and 0.92, respectively).
  
  
  CONCLUSIONS
  Chlamydia and gonorrhoea may infect the prostate of some infected men.
authors.affiliation: Division of Public Health Sciences and the Alvin J. Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8100, Room 5026, St Louis, MO 63110, USA. sutcliffes@wudosis.wustl.edu
authors.forename: S
authors.initials: S
authors.lastname: Sutcliffe
authors.forename: R L
authors.initials: RL
authors.lastname: Nevin
authors.forename: R
authors.initials: R
authors.lastname: Pakpahan
authors.forename: D J
authors.initials: DJ
authors.lastname: Elliott
authors.forename: S R
authors.initials: SR
authors.lastname: Cole
authors.forename: A M
authors.initials: AM
authors.lastname: De Marzo
authors.forename: C A
authors.initials: CA
authors.lastname: Gaydos
authors.forename: W B
authors.initials: WB
authors.lastname: Isaacs
authors.forename: W G
authors.initials: WG
authors.lastname: Nelson
authors.forename: L J
authors.initials: LJ
authors.lastname: Sokoll
authors.forename: J M
authors.initials: JM
authors.lastname: Zenilman
authors.forename: S B
authors.initials: SB
authors.lastname: Cersovsky
authors.forename: E A
authors.initials: EA
authors.lastname: Platz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000097:blood / Q000453:epidemiology; D006069:Gonorrhea / Q000097:blood / Q000453:epidemiology; D006801:Humans; D008297:Male; D008889:Military Personnel / Q000706:statistics & numerical data; D009994:Osmolar Concentration; D011467:Prostate / Q000382:microbiology / Q000473:pathology / Q000502:physiology*; D017430:Prostate-Specific Antigen / Q000032:analysis / Q000097:blood*; D012749:Sexually Transmitted Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000635:transmission
chemical_list: D017430:Prostate-Specific Antigen