title: A pilot study to assess the use of the gonadotrophin antagonist cetrorelix in preserving ovarian function during chemotherapy.
abstract: Cyclophosphamide treatment can cause premature ovarian failure. This pilot study evaluates the protective effect of the gonadotrophin releasing hormone (GnRH) antagonist, cetrorelix, on ovarian function, when used during cyclophosphamide chemotherapy in women aged 18-35. Primary outcomes measured were serum follicle stimulating hormone (FSH) and inhibin prior to and at 6 and 12 months after chemotherapy. Secondary outcomes were hormonal evidence of a suppressive effect and the side effect profile.
authors.affiliation: Melbourne IVF, Australia. julie.whitehead@mivf.com.au
authors.forename: Julie
authors.initials: J
authors.lastname: Whitehead
authors.forename: Manuela G
authors.initials: MG
authors.lastname: Toledo
authors.forename: Catharyn J
authors.initials: CJ
authors.lastname: Stern
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology; D001327:Autoimmune Diseases / Q000188:drug therapy; D001943:Breast Neoplasms / Q000188:drug therapy; D003520:Cyclophosphamide / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D059247:Fertility Preservation; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006727:Hormone Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007265:Inhibins / Q000097:blood; D008223:Lymphoma / Q000188:drug therapy; D058958:Organs at Risk / Q000502:physiology; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D010865:Pilot Projects; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced* / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D007265:Inhibins; D003520:Cyclophosphamide; D005640:Follicle Stimulating Hormone; C062876:cetrorelix