title: Odour transduction in olfactory receptor neurons.
abstract: The molecular mechanisms that control the binding of odorant to olfactory receptors and transduce this signal into membrane depolarization are reviewed. They are compared in vertebrates and insects for interspecific (allelochemicals) and intraspecific (pheromones) olfactory signals. Attempts to develop quantitative models of these multistage signalling networks are presented. Computational analysis of olfactory transduction is still in its infancy and appears as a promising area for future developments.
authors.affiliation: INRA, UMR 1272 Physiologie de l'Insecte: Signalisation et Communication, Versailles, France. jean-pierre.rospars@versailles.inra.fr
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Rospars
authors.forename: Yuqiao
authors.initials: Y
authors.lastname: Gu
authors.forename: Alexandre
authors.initials: A
authors.lastname: Grémiaux
authors.forename: Philippe
authors.initials: P
authors.lastname: Lucas
mesh_terms: D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D009812:Odorants; D018034:Olfactory Receptor Neurons / Q000502:physiology*; D010675:Pheromones / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007473:Ion Channels; D010675:Pheromones