title: [TNF and cytokines and pain: Beyond the tisular inflammation].
abstract: Numerous studies support the participation of cytokines in the transmission of pain, especially in neuropathic pain. Results obtained both from different experimental pain models as well as studies from a clinical perspective implicate diverse cytokines, especially some of a proinflammatory nature, in the physiopathology of chronic pain. Selective pharmacologic manipulation of these pathways key molecules represents and constitutes a treatment opportunity and an answer to this painful pathology which currently has a difficult solution.
authors.affiliation: Departamento de Neurociencias, Universidad de Cádiz, CIBER de Salud Mental (CIBERSAM), Cádiz, España.
authors.forename: M A Remedios
authors.initials: MA
authors.lastname: Moreno Brea
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Micó