title: [The association of Serenoa repens, lycopene and selenium is superior to Serenoa repens alone in reducing benign prostatic hyperplasia].
abstract: Serenoa repens (SeR) is frequently associated with other natural compounds, such as lycopene (Ly), a carotenoid, and selenium (Se), an essential trace element, to increase its therapeutic activity in benign prostatic hyperplasia (BPH). The LY-Se-SeR association has a greater and stronger anti-inflammatory activity than SeR alone. In addition, the LY-Se-SeR combination is more effective than SeR alone in reducing prostate weight and hyperplasia, augmenting apoptosis, and reducing cell proliferation and growth factor expression. This experimental evidence suggests that Ly-Se-SeR association is superior to SeR alone in reducing benign prostate growth.
authors.affiliation: Department of Clinical and experimental Medicine, University of Messina, Messina -Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Squadrito
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Morgia
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D002338:Carotenoids / Q000008:administration & dosage / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004815:Epidermal Growth Factor / Q000096:biosynthesis; D000077276:Lycopene; D008297:Male; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D011467:Prostate / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D011897:Random Allocation; D051381:Rats; D012643:Selenium / Q000008:administration & dosage / Q000627:therapeutic use*; D028024:Serenoa; D001748:Urinary Bladder Neck Obstruction / Q000188:drug therapy; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat; D002338:Carotenoids; D004815:Epidermal Growth Factor; D012643:Selenium; D000077276:Lycopene