title: Serial measurement of tear meniscus by FD-OCT after instillation of artificial tears in patients with dry eyes.
abstract: OBJECTIVE
  To use Fourier-domain optical coherence tomography (FD-OCT) to study the effect of artificial tears on the tear meniscus in patients with dry eyes.
  
  
  METHODS
  The lower tear meniscus of 16 consecutive patients with dry eyes was imaged by an FD-OCT system (RTVue; Optovue, Inc., Fremont, CA). Baseline and five serial pairs of measurements were taken after the instillation of artificial tears (Optive; Allergan, Irvine, CA) at 1, 2, 5, 10, and 15 minutes. The lower meniscus height, depth, and area were measured with a computer caliper.
  
  
  RESULTS
  Baseline meniscus measurements were 235.5 ± 150.0 μm, 138.1 ± 78.7 μm, and 0.020 ± 0.022 mm(2) for height, depth, and area, respectively. After instillation of artificial tears, all lower tear meniscus parameters remained significantly elevated for 5 minutes and returned to baseline by 10 minutes.
  
  
  CONCLUSIONS
  FD-OCT is able to quantify a dramatic initial increase in tear meniscus, followed by a decay back to baseline values after approximately 5 minutes. FD-OCT may be useful in objectively quantifying the dynamic efficacy of dry eye treatments.
authors.affiliation: Doheny Eye Institute, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Bujak
authors.forename: Samuel
authors.initials: S
authors.lastname: Yiu
authors.forename: Xinbo
authors.initials: X
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: David
authors.initials: D
authors.lastname: Huang
mesh_terms: D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D011446:Prospective Studies; D013666:Tears / Q000378:metabolism*; D041623:Tomography, Optical Coherence
chemical_list: D009883:Ophthalmic Solutions