title: Treatment approaches of gastrointestinal dysfunction in Parkinson's disease, therapeutical options and future perspectives.
abstract: Gastrointestinal (GI) dysfunction is a common but underestimated feature in Parkinson's disease (PD). Out of the multimodal spectrum of treatment options, there currently are only a few pharmacological treatments available to improve gastrointestinal motility and symptoms. Because enteric nervous function is mainly regulated by transmitters different from those involved in the brain, dopamine replacement is not a treatment option in PD patients. This article focuses on the known regulative mechanism of GI function and presents known and upcoming treatment options for GI dysfunction in PD.
authors.affiliation: Department of Neurology, St. Josef Hospital, Ruhr-University-Bochum, Germany. Dirk.Woitalla@rub.de
authors.forename: D
authors.initials: D
authors.lastname: Woitalla
authors.forename: O
authors.initials: O
authors.lastname: Goetze
mesh_terms: D002490:Central Nervous System / Q000503:physiopathology; D017615:Enteric Nervous System / Q000503:physiopathology*; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D010300:Parkinson Disease / Q000150:complications*