title: An association study of polymorphisms in JAK3 gene with lung cancer in the Korean population.
abstract: OBJECTIVE
  The genetic alteration of the janus kinases (JAKs), non-receptor tyrosine kinase, is related to the development of human cancers. However, little is known about how the sequence variation of JAK3 contributes to the development of lung cancer. This study investigated whether polymorphisms at the promoter region of the JAK3 gene are associated with the risk of lung cancer in the Korean population.
  
  
  METHODS
  A total of 819 subjects, including 409 lung cancer patients and 410 healthy controls were recruited. The SNaPshot assay and polymerase chain reaction-restriction fragment length polymorphism analysis were used, and logistic regression analyses were performed to characterize the association between polymorphisms of JAK3 and lung cancer risk.
  
  
  RESULTS
  Three polymorphisms (-672 G>A, +64 A>G and +227 G>A) of JAK3 were analyzed for large-scale genotyping (n=819). Statistical analyses revealed that polymorphisms and haplotypes in the JAK3 gene were not significantly associated with lung cancer.
  
  
  CONCLUSIONS
  JAK3 gene was not significantly associated with the risk of lung cancer in the Korean population.
authors.affiliation: Brain Korea 21 Project for Biomedical Science, Seoul, Korea.
authors.forename: Wonbeak
authors.initials: W
authors.lastname: Yoo
authors.forename: Hae-Yun
authors.initials: HY
authors.lastname: Jung
authors.forename: Seungjoon
authors.initials: S
authors.lastname: Lim
authors.forename: Jae Sook
authors.initials: JS
authors.lastname: Sung
authors.forename: Kyong Hwa
authors.initials: KH
authors.lastname: Park
authors.forename: Jeong Seon
authors.initials: JS
authors.lastname: Ryu
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Shin
authors.forename: Jun Suk
authors.initials: JS
authors.lastname: Kim
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Seo
authors.forename: Yeul Hong
authors.initials: YH
authors.lastname: Kim