title: Perfluorocarbon exposure, gender and thyroid function in the C8 Health Project.
abstract: Perfluorocarbons from common household products such as food containers, stain- resistant protection for clothing, furniture and carpets, paints, and fire-fighting foams are found in soil, water, plants, animal and human serum worldwide. Previous research has shown a significant association between these chemicals and thyroid disease in women. The present data from the C8 Health Project assessed thyroid function in a cross-sectional analysis of 52,296 adults with a year or more of exposure to perfluorooctanoate (PFOA) from drinking water. Outcomes were: thyroxine, T3 uptake, and thyroid stimulating hormone (TSH). Analyses were stratified by gender and age group (< 20 - < 50 years and > 50). Both PFOA and perfluorooctane sulfonate (PFOS) were associated with significant elevations in serum thyroxine and a significant reduction in T3 uptake in all participants. There were also significant gender/PFOS interactions for T3( )uptake and thyroxine, as well as gender/PFOA interactions for T3 uptake. Results provide evidence for disruption of thyroid function related to these common chemicals and possible mechanisms are discussed.
authors.affiliation: Department of Community Medicine, West Virginia University School of Medicine, Morgantown, WV 26506, USA. sknox@hsc.wvu.edu
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Knox
authors.forename: Timothy
authors.initials: T
authors.lastname: Jackson
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Frisbee
authors.forename: Beth
authors.initials: B
authors.lastname: Javins
authors.forename: Alan M
authors.initials: AM
authors.lastname: Ducatman
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012727:Sex Characteristics; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood; D014874:Water Pollutants, Chemical / Q000097:blood*; D014903:West Virginia; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005466:Fluorocarbons; D013963:Thyroid Hormones; D014874:Water Pollutants, Chemical