title: Mitochondria in innate immunity.
abstract: Mitochondria are cellular organelles involved in host-cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS-a crucial adaptor for RIGI-like receptor signalling-as a mitochondria-anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 and IRGM have been functionally associated with mitochondria. Furthermore, mitochondrial alarmins-such as mitochondrial DNA and formyl peptides-can be released by damaged mitochondria and trigger inflammation. Therefore, mitochondria emerge as a fundamental hub for innate immune signalling.
authors.affiliation: INSERM U, Hopital Paul Brousse, Batiment Lavoisier, Villejuif, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Arnoult
authors.forename: Fraser
authors.initials: F
authors.lastname: Soares
authors.forename: Ivan
authors.initials: I
authors.lastname: Tattoli
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Girardin
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D006801:Humans; D007113:Immunity, Innate; D008928:Mitochondria / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D024101:Mitochondrial Proteins