title: Statistical analysis and interpretation of prenatal diagnostic imaging studies, Part 1: evaluating the efficiency of screening and diagnostic tests.
abstract: Screening and diagnostic testing play fundamental roles in all fields of clinical medicine, with obstetric imaging and prenatal diagnosis being no exceptions. With advances in maternal serum screening and ultrasound technology, much research effort in the field of pre-natal diagnosis has actually been dedicated to the development and refinement of screening tests for fetal aneuploidy and other congenital disorders. This article aims to review the differences between screening and diagnostic tests, describe the accepted criteria for an efficient screening test, and provide an overview of the calculation and interpretation of test performance characteristics in relation to prenatal imaging studies.
authors.affiliation: Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes-Jewish Hospital Plaza, Campus Box 8064, St Louis, MO 63110, USA.
authors.forename: Katherine R
authors.initials: KR
authors.lastname: Goetzinger
authors.forename: Anthony O
authors.initials: AO
authors.lastname: Odibo
mesh_terms: D004526:Efficiency; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D015233:Models, Statistical; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000379:methods*