title: A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation.
abstract: We now seem to live in a small world, in which everyone is highly interconnected. Cells, too, often also display tremendous interconnectivities in their component systems. As a recent case in point, we have identified a conserved protein complex--the SEA complex--that links the nuclear pore complex (NPC), the COPII vesicle coating complex, vacuoles and autophagy. In this punctum we will discuss the properties of this novel complex.
authors.affiliation: CNRS UMR 8126, Université Paris-Sud 11, Institut Gustave Roussy, Villejuif, France. svetlana.dokudovskaya@igr.fr
authors.forename: Svetlana
authors.initials: S
authors.lastname: Dokudovskaya
authors.forename: Michael P
authors.initials: MP
authors.lastname: Rout
mesh_terms: D022181:COP-Coated Vesicles / Q000187:drug effects / Q000378:metabolism*; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism*; D009584:Nitrogen / Q000172:deficiency* / Q000494:pharmacology; D022022:Nuclear Pore / Q000187:drug effects / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D017433:Protein Structure, Secondary; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism*; D014617:Vacuoles / Q000187:drug effects / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D029701:Saccharomyces cerevisiae Proteins; D009584:Nitrogen