title: [The configuration of soft palate muscular phenotype in obstructive sleep apnea hypopnea syndrome].
abstract: OBJECTIVE
  To study the mRNA expression of muscle phenotype and collagen of soft palate and pathology in obstructive sleep apnea hypopnea syndrome (OSAHS).
  
  
  METHODS
  We used the Real-time PCR to test the mRNA expression of soft palate muscle myosin heavy chain (MyHC) phenotype and collagen in 12 OSAHS patients and 8 control patients. We also distinguished the muscle isoforms I , II with ATPase staining, then counted the numbers of isoforms muscle fiber.
  
  
  RESULTS
  The mRNA expression of OSAHS group was more than control group in II A MyHC phenotype (P<0.01). The number of OSAHS group muscle fibre I isoform was less than control group with pH4. 3 ATPase staining (P<0.05).
  
  
  CONCLUSIONS
  Compare to control group, the enhancement happened in the mRNA expression of II A MyHC phenotype which can increase the velocity and power but de crease the enduring quality of muscle in OSAHS, and the reduce be in the I MyHC isoform of muscle fiber that can cause muscle velocity become slower and persistency become longer in OSAHS patients.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, the Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
authors.forename: Siyi
authors.initials: S
authors.lastname: Zhang
authors.forename: Rongming
authors.initials: R
authors.lastname: Nie
authors.forename: Pingjiang
authors.initials: P
authors.lastname: Ge
authors.forename: Shaofeng
authors.initials: S
authors.lastname: Liu
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Lu
authors.forename: Runmei
authors.initials: R
authors.lastname: Ge
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Sheng
authors.forename: Shaohua
authors.initials: S
authors.lastname: Chen
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000378:metabolism / Q000473:pathology*; D018995:Myosin Heavy Chains / Q000378:metabolism*; D010160:Palate, Soft / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D020033:Protein Isoforms / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D020181:Sleep Apnea, Obstructive / Q000378:metabolism / Q000473:pathology*
chemical_list: D020033:Protein Isoforms; D012333:RNA, Messenger; D018995:Myosin Heavy Chains