title: Alzheimer's disease genetics: lessons to improve disease modelling.
abstract: In the present review, we look back at the recent history of GWAS (genome-wide association studies) in AD (Alzheimer's disease) and integrate the major findings with current knowledge of biological processes and pathways. These topics are essential for the development of animal models, which will be fundamental to our complete understanding of AD.
authors.affiliation: Department of Molecular Neuroscience, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors.forename: Rita J
authors.initials: RJ
authors.lastname: Guerreiro
authors.forename: John
authors.initials: J
authors.lastname: Hardy
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D003165:Complement System Proteins / Q000235:genetics; D004195:Disease Models, Animal; D004705:Endocytosis / Q000235:genetics; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
chemical_list: D016229:Amyloid beta-Peptides; D003165:Complement System Proteins