title: The intake of grain fibers modulates cytokine levels in blood.
abstract: Dietary fiber may modulate the environment of the intestinal lumen, alter the intestinal microflora populations, and influence the immune response and disease risk. Epidemiological investigations have suggested that higher fiber intake is associated with lower overall mortality, in particular from cardiovascular and digestive tract diseases. Here a panel of 17 cytokines and chemokines were measured in plasma of 88 cancer-free subjects sampled within the Italian EPIC-Italy cohort. A statistically significant inverse association (p-trend = 0.01) was observed for cereal fiber and cytokines included in the main factor in factor analysis (IL-1β, IL-4, IL-5, IL-6, IL-13, and TNF-α), which alone explained 35.5% of variance. Our study suggests that fiber intake, especially cereal fiber, may be associated with a decreased level of pro-inflammatory cytokines.
authors.affiliation: Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, UK.
authors.forename: Shu-Chun
authors.initials: SC
authors.lastname: Chuang
authors.forename: Roel
authors.initials: R
authors.lastname: Vermeulen
authors.forename: Mansour T A
authors.initials: MT
authors.lastname: Sharabiani
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.forename: S H
authors.initials: SH
authors.lastname: Fatemeh
authors.forename: Franco
authors.initials: F
authors.lastname: Berrino
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Toby James
authors.initials: TJ
authors.lastname: Athersuch
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage*; D002523:Edible Grain / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000276:immunology / Q000517:prevention & control*; D007558:Italy; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires
chemical_list: D016207:Cytokines; D004043:Dietary Fiber