title: [Spread and features of chronic and recurrent infectious diseases in patients with primary headache].
abstract: OBJECTIVE
  Study of spread and clinical-immunologic features of chronic and recurrent infectious diseases in patients with primary headache.
  
  
  METHODS
  158 patients with migraine and 79 patients with tension headache were examined. Diagnostics of chronic and recurrent infectious diseases were carried out by the appropriate specialists according to the current standards. Immunologic studies included evaluation of cellular, humoral, innate immunity, cytokine status parameters.
  
  
  RESULTS
  Spread of chronic and recurrent infectious diseases, that were considered as clinical manifestations of secondary immunodeficiency, in patients with primary headache exceeded the spread in the population of the region. In the patients with a combination of cephalgia and infectious pathology a tendency of leucopenia, lymphocyte subpopulation composition disorders, neutrophil functional activity, IgG level decrease, cytokine system imbalance were characteristic. In chronic primary headache course rate of occurrence of infectious diseases and intensity of immune status disorders were higher than in episodic course of these cephalgias.
  
  
  CONCLUSIONS
  Results of these studies suggest a connection between chronic and recurrent infectious diseases within secondary immunodeficiency with primary headache.
authors.forename: M I
authors.initials: MI
authors.lastname: Karpova
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Shamurova
authors.forename: V V
authors.initials: VV
authors.lastname: Markova
authors.forename: V F
authors.initials: VF
authors.lastname: Pecherkin
mesh_terms: D002908:Chronic Disease; D003141:Communicable Diseases / Q000150:complications / Q000453:epidemiology* / Q000276:immunology*; D006261:Headache / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000276:immunology; D008881:Migraine Disorders / Q000453:epidemiology* / Q000209:etiology; D012008:Recurrence; D018781:Tension-Type Headache / Q000453:epidemiology* / Q000209:etiology