title: Detection of rheumatoid arthritis by evaluation of normalized variances of fluorescence time correlation functions.
abstract: Fluorescence imaging using the dye indocyanine green as a contrast agent was investigated in a prospective clinical study for the detection of rheumatoid arthritis. Normalized variances of correlated time series of fluorescence intensities describing the bolus kinetics of the contrast agent in certain regions of interest were analyzed to differentiate healthy from inflamed finger joints. These values are determined using a robust, parameter-free algorithm. We found that the normalized variance of correlation functions improves the differentiation between healthy joints of volunteers and joints with rheumatoid arthritis of patients by about 10% compared to, e.g., ratios of areas under the curves of raw data.
authors.affiliation: Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin, Germany. thomas.dziekan@ptb.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Dziekan
authors.forename: Carmen
authors.initials: C
authors.lastname: Weissbach
authors.forename: Jan
authors.initials: J
authors.lastname: Voigt
authors.forename: Bernd
authors.initials: B
authors.lastname: Ebert
authors.forename: Rainer
authors.initials: R
authors.lastname: Macdonald
authors.forename: Malte L
authors.initials: ML
authors.lastname: Bahner
authors.forename: Marianne
authors.initials: M
authors.lastname: Mahler
authors.forename: Michael
authors.initials: M
authors.lastname: Schirner
authors.forename: Michael
authors.initials: M
authors.lastname: Berliner
authors.forename: Birgitt
authors.initials: B
authors.lastname: Berliner
authors.forename: Jens
authors.initials: J
authors.lastname: Osel
authors.forename: Ilka
authors.initials: I
authors.lastname: Osel
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D004396:Coloring Agents; D003952:Diagnostic Imaging / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D005384:Finger Joint / Q000098:blood supply / Q000473:pathology; D005453:Fluorescence; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D055815:Young Adult
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green