title: The effect of neurogranin on neural correlates of episodic memory encoding and retrieval.
abstract: Neurogranin (NRGN) is the main postsynaptic protein regulating the availability of calmodulin-Ca(2+) in neurons. NRGN is expressed exclusively in the brain, particularly in dendritic spines and has been implicated in spatial learning and hippocampal plasticity. Genetic variation in rs12807809 in the NRGN gene has recently been confirmed to be associated with schizophrenia in a meta-analysis of genome-wide association studies: the T-allele was found to be genome-wide significantly associated with schizophrenia. Cognitive tests and personality questionnaires were administered in a large sample of healthy subjects. Brain activation was measured with functional magnetic resonance imaging (fMRI) during an episodic memory encoding and retrieval task in a subsample. All subjects were genotyped for NRGN rs12807809. There was no effect of genotype on personality or cognitive measures in the large sample. Homozygote carriers of the T-allele showed better performance in the retrieval task during fMRI. After controlling for memory performance, differential brain activation was evident in the anterior cingulate cortex for the encoding and posterior cingulate regions during retrieval. We could demonstrate that rs12807809 of NRGN is associated with differential neural functioning in the anterior and posterior cingulate. These areas are involved in episodic memory processes and have been implicated in the pathophysiology of schizophrenia in structural and functional imaging as well as postmortem studies.
authors.affiliation: Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany. Axel.Krug@med.uni-marburg.de
authors.forename: Axel
authors.initials: A
authors.lastname: Krug
authors.forename: Sören
authors.initials: S
authors.lastname: Krach
authors.forename: Andreas
authors.initials: A
authors.lastname: Jansen
authors.forename: Vanessa
authors.initials: V
authors.lastname: Nieratschker
authors.forename: Stephanie H
authors.initials: SH
authors.lastname: Witt
authors.forename: N Jon
authors.initials: NJ
authors.lastname: Shah
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Tilo
authors.initials: T
authors.lastname: Kircher
mesh_terms: D000328:Adult; D055106:Genome-Wide Association Study; D005838:Genotype; D006179:Gyrus Cinguli / Q000378:metabolism / Q000503:physiopathology*; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D051579:Neurogranin / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010551:Personality / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D051579:Neurogranin