title: Biotransformation of a taxadiene by ginkgo cell cultures and the tumor multi-drug resistant reversal activities of the metabolites.
abstract: The biotransformation of 2α,5α,10β-triacetoxy-14-oxo-taxa-4(20),11-diene (1) by cultured Gingko cells afforded four products. Their structures were identified on the basis of analyses of the chemical and spectroscopic (IR, MS, ¹H- and ¹³C-NMR) data. Among them, 2, 3 and 5 were three new compounds, and 4 displayed potent multi-drug resistant (MDR) reversal activities to MX-1/T tumor MDR cells.
authors.affiliation: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zou
authors.forename: Dali
authors.initials: D
authors.lastname: Yin
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Chen
authors.forename: Jungui
authors.initials: J
authors.lastname: Dai
mesh_terms: D000475:Alkenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D001711:Biotransformation; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D004224:Diterpenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D020441:Ginkgo biloba / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D017239:Paclitaxel / Q000494:pharmacology
chemical_list: D000475:Alkenes; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C093125:taxa-4(5),11(12)diene; D017239:Paclitaxel