title: Oestrogen receptor polymorphisms and late-life depression.
abstract: BACKGROUND
  Evidence suggests a role for oestrogen in depression but the involvement of oestrogen receptor polymorphisms remains unknown.
  
  
  OBJECTIVE
  To determine the association between oestrogen receptor polymorphisms and late-life depression and the modifying effect of hormone treatment.
  
  
  METHODS
  Depression was assessed using the Mini-International Neuropsychiatric Interview, according to DSM-IV criteria and the Centre for Epidemiologic Studies - Depression Scale. The association between oestrogen receptor α and β (ER-α and ER-β) polymorphisms with severe depression was examined in 6017 community-dwelling elderly people using multivariate logistic regression.
  
  
  RESULTS
  In women, the ER-α rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depression. The A allele of ER-β rs1256049 increased the risk of depression, but only for non-current users of hormone treatment. In men, only the ER-β rs4986938 polymorphism showed a weak association with depression risk.
  
  
  CONCLUSIONS
  Oestrogen receptor polymorphisms are associated with severe late-life depression risk in women only.
authors.affiliation: Inserm U1061, Hôpital La Colombière, 39 Avenue Charles Flahault, BP 34493, 34093 Montpellier Cedex 5, France. joanne.ryan@inserm.fr
authors.forename: Joanne
authors.initials: J
authors.lastname: Ryan
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Scali
authors.forename: Isabelle
authors.initials: I
authors.lastname: Carrière
authors.forename: Karine
authors.initials: K
authors.lastname: Peres
authors.forename: Olivier
authors.initials: O
authors.lastname: Rouaud
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Scarabin
authors.forename: Karen
authors.initials: K
authors.lastname: Ritchie
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Ancelin
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000235:genetics*; D015987:Effect Modifier, Epidemiologic; D015914:Estrogen Replacement Therapy; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011960:Receptors, Estrogen / Q000235:genetics*
chemical_list: D011960:Receptors, Estrogen