title: Meeting report: mode(s) of action of asbestos and related mineral fibers.
abstract: BACKGROUND
  Although asbestos in general is well known to cause a range of neoplastic and non-neoplastic human health effects, not all asbestos fiber types have the same disease-causing potential, and the mode of action (MOA) of specific types of asbestos and related fibers for various health outcomes are not well understood.
  
  
  OBJECTIVE
  A workshop was held to discuss the state of the science of the MOA for asbestos-related disease. The objective was to review the range of asbestos-induced health effects (including those at sites remote to the respiratory tract). We sought to identify existing knowledge gaps and define what research is needed to address these gaps and advance asbestos research.
  
  
  CONCLUSIONS
  Discussions centered on areas of uncertainty in the field, including the ways asbestos is defined and characterized, the role of different fiber characteristics (e.g., length and mineralogy) in disease, and the impact of low-dose exposures on human health. Studying the dosimetry and mode of action of multiple fiber types would enhance our understanding of asbestos-related disease. To better elucidate the MOA of specific asbestos fibers, the risk assessor requires data as to specific characteristics of asbestos in determining fiber toxicity (e.g., surface area, mineral type), which may inform efforts to assess and control exposures and prevent adverse human health outcomes for the diverse range of fiber types. Specific research aims were defined for these topics and for overarching issues to be addressed, including the use of standardized terminology, test materials, and better experimental models to aid in data extrapolation to humans.
  
  
  CONCLUSIONS
  To resolve these and other issues, participants agreed that diverse scientific disciplines must coordinate to better understand the MOA leading to the various asbestos-related disease end points.
authors.affiliation: National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC 20460, USA. gwinn.maureen@epa.gov
authors.forename: Maureen R
authors.initials: MR
authors.lastname: Gwinn
authors.forename: Danielle
authors.initials: D
authors.lastname: DeVoney
authors.forename: Annie M
authors.initials: AM
authors.lastname: Jarabek
authors.forename: Babasaheb
authors.initials: B
authors.lastname: Sonawane
authors.forename: John
authors.initials: J
authors.lastname: Wheeler
authors.forename: David N
authors.initials: DN
authors.lastname: Weissman
authors.forename: Scott
authors.initials: S
authors.lastname: Masten
authors.forename: Claudia
authors.initials: C
authors.lastname: Thompson
mesh_terms: D001194:Asbestos / Q000737:chemistry / Q000145:classification / Q000633:toxicity*; D004493:Education; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000503:physiopathology*; D009369:Neoplasms / Q000139:chemically induced* / Q000503:physiopathology*; D009626:Terminology as Topic
chemical_list: D001194:Asbestos