title: Apheresis as rescue therapy in a severe case of sudden hearing loss.
abstract: A 23-year-old man complained of progressive left ear hearing loss and tinnitus and was unsuccessfully treated with steroids and mannitol. Four months later he presented with sudden, severe, asymmetrical, bilateral sensorineural hearing loss. The results of the laboratory workup were normal except for antinuclear autoantibodies. Auditory brain stem responses showed absent peak and interpeak latencies on both sides. The combination of plasma exchange with high doses of steroids resulted in a definite improvement. Plasmapheresis combined with steroid administration can be used as second-line therapy in idiopathic, sudden sensorineural hearing loss.
authors.affiliation: Center of Research on Immunopathology and Documentation of Rare Diseases (CMID), G. Bosco Hospital, Turin, Italy.
authors.forename: Mirella
authors.initials: M
authors.lastname: Alpa
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Bucolo
authors.forename: Fabio
authors.initials: F
authors.lastname: Beatrice
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Giachino
authors.forename: Dario
authors.initials: D
authors.lastname: Roccatello
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D003639:Hearing Loss, Sudden / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D012720:Severity of Illness Index; D013256:Steroids / Q000008:administration & dosage; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000974:Antibodies, Antinuclear; D013256:Steroids