title: Myeloid derived suppressor cells in transplantation.
abstract: Myeloid derived suppressor cells (MDSC) are a heterogeneous population of hematopoietic derived cell precursors that can suppress immune responses in a variety of inflammatory settings. Here we review recent studies detailing expansion of phenotypically and functionally disparate MDSC. Findings related to MDSC accumulation, activation, and mechanisms utilized in immune suppression are presented. Further, we discuss recent reports that suggest MDSC are expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection.
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Lees
authors.forename: Agnes M
authors.initials: AM
authors.lastname: Azimzadeh
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Bromberg
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000941:Antigens / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D049109:Cell Proliferation; D016207:Cytokines / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007113:Immunity, Innate; D007165:Immunosuppression Therapy; D007249:Inflammation / Q000276:immunology; D036341:Intercellular Signaling Peptides and Proteins / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D023461:Myeloid Progenitor Cells / Q000276:immunology / Q000637:transplantation; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D016377:Organ Transplantation
chemical_list: D000941:Antigens; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins