title: Thoroughly modern medicine.
abstract: Personalized medicine is receiving increasing attention in the medical literature and lay press as one way to optimize therapy and reduce complications of treatment for almost any disorder. However, understanding the systemic complexities necessary to implement the ambitious goals of personalized medicine is unlikely to arise from the study of common disorders. Rather, dissecting out the individual components to therapeutic response is far more feasible with defined disorders of known cause. Inborn errors of metabolism offer an attractive opportunity to better define the hyperbole surrounding development and institution of personalized medicine.
authors.affiliation: University of Pittsburgh Graduate School of Public Health, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, Pittsburgh, PA 15238, USA.
authors.forename: Georgianne L
authors.initials: GL
authors.lastname: Arnold
authors.forename: Jerry
authors.initials: J
authors.lastname: Vockley
mesh_terms: D003695:Delivery of Health Care; D019317:Evidence-Based Medicine; D006801:Humans; D008403:Mass Screening; D008661:Metabolism, Inborn Errors / Q000628:therapy; D057285:Precision Medicine; D013223:Statistics as Topic