title: Outcomes and risk prediction model for peripheral arterial disease in patients with stable coronary artery disease.
abstract: We used the National Heart, Lung, and Blood Institute Limited Access Dataset of Prevention of Events with Angiotensin-Converting Enzyme Inhibition (PEACE) Trial (n = 8290) which included patients with stable coronary artery disease (CAD) and preserved ejection fraction (>40%). We identified risk factors for the development of critical peripheral arterial disease (PAD; those needing angioplasty, bypass grafting, or aneurysm repair) and formulated a risk score by multivariate analyses. A total of 220 patients (2.8%) developed critical PAD over a mean follow-up of 4.7 years. Significant predictors of critical PAD were history of intermittent claudication, smoking, hypertension (HTN), coronary-artery bypass grafting (CABG), diabetes, age, serum cholesterol, and body mass index (BMI). Incident critical PAD was associated with increased composite outcome of cardiovascular death, myocardial infarction, percutaneous transluminal coronary angioplasty, or CABG (hazard ratio 1.82, 95% CI 1.50-2.22, P < .001). Risk assessment using our score may identify CAD patients at risk for critical PAD events.
authors.affiliation: Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA.
authors.forename: Apurva O
authors.initials: AO
authors.lastname: Badheka
authors.forename: Ankit D
authors.initials: AD
authors.lastname: Rathod
authors.forename: Aditya S
authors.initials: AS
authors.lastname: Bharadwaj
authors.forename: Samrat
authors.initials: S
authors.lastname: Bhat
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Kizilbash
authors.forename: Vikas
authors.initials: V
authors.lastname: Veeranna
authors.forename: Victorio
authors.initials: V
authors.lastname: Pidlaon
authors.forename: Sony
authors.initials: S
authors.lastname: Jacob
authors.forename: Luis
authors.initials: L
authors.lastname: Afonso
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D015233:Models, Statistical; D058729:Peripheral Arterial Disease / Q000453:epidemiology* / Q000209:etiology*; D011379:Prognosis; D018570:Risk Assessment