title: Antibodies that induce phagocytosis of malaria infected erythrocytes: effect of HIV infection and correlation with clinical outcomes.
abstract: HIV infection increases the burden of disease of malaria in pregnancy, in part by impairing the development of immunity. We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected). In women with placental malaria infection, phagocytic antibodies to CS2(VSA) were decreased in the presence of HIV (p = 0.011) and correlated positively with infant birth weight (coef = 3.57, p = 0.025), whereas total IgG to CS2(VSA) did not. Phagocytic antibodies to CS2(VSA) are valuable tools to study acquired immunity to malaria in the context of HIV co-infection. Secundigravidae may be an informative group for identification of correlates of immunity.
authors.affiliation: Department of Medicine (RMH/WH), University of Melbourne, Post Office Royal Melbourne Hospital, Melbourne, Victoria, Australia. ric.ataide@gmail.com
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ataíde
authors.forename: Victor
authors.initials: V
authors.lastname: Mwapasa
authors.forename: Malcolm E
authors.initials: ME
authors.lastname: Molyneux
authors.forename: Steven R
authors.initials: SR
authors.lastname: Meshnick
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Rogerson
mesh_terms: D000913:Antibodies, Protozoan / Q000276:immunology*; D000953:Antigens, Protozoan / Q000276:immunology; D001724:Birth Weight / Q000276:immunology; D015331:Cohort Studies; D004912:Erythrocytes / Q000469:parasitology* / Q000473:pathology*; D005260:Female; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D008288:Malaria / Q000150:complications* / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology*; D010920:Placenta / Q000469:parasitology / Q000473:pathology; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000469:parasitology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D006454:Hemoglobins