title: New 4-deoxy-(1→3)-β-D-glucan-based oligosaccharides and their immunostimulating potential.
abstract: (1→3)-β-D-Glucans are well-established natural biological immunomodulators. However, problems inherited with the natural origin of these polysaccharides bring about significant setbacks, including batch-to-batch heterogeneity and significant differences based on the source and isolation techniques. In this study, we tried to overcome these problems by preparation of a quantitatively new set of oligo-(1→3)-β-D-glucan-based synthetic immunomodulators. Some of these non-natural oligosaccharides showed biological activities, such as stimulation of phagocytosis, modulation of gene expression, and anti-cancer activity, which were superior to natural glucans.
authors.affiliation: University of Louisville, Department of Pathology, Louisville, KY 40202, USA. vaclav.vetvicka@louisville.edu
authors.forename: Vaclav
authors.initials: V
authors.lastname: Vetvicka
authors.forename: Sujata
authors.initials: S
authors.lastname: Saraswat-Ohri
authors.forename: Aruna
authors.initials: A
authors.lastname: Vashishta
authors.forename: Karine
authors.initials: K
authors.lastname: Descroix
authors.forename: Frank
authors.initials: F
authors.lastname: Jamois
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Yvin
authors.forename: Vincent
authors.initials: V
authors.lastname: Ferrières
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D002240:Carbohydrate Sequence; D002460:Cell Line; D005260:Female; D005936:Glucans / Q000737:chemistry*; D006801:Humans; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D012624:Seaweed / Q000737:chemistry
chemical_list: D000276:Adjuvants, Immunologic; D005936:Glucans; D009844:Oligosaccharides