title: An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors.
abstract: (Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one (7a-q) derivatives have been synthesized by the condensation reaction of 3-phenyl-2-thioxothiazolidin-4-ones (3a-h) with suitably substituted 2-(1H-indol-3-yl)-2-oxoacetaldehyde (6a-d) under microwave condition. The thioxothiazolidine-4-ones were prepared from corresponding aromatic amines (1a-e) and di-(carboxymethyl)-trithiocarbonyl (2). The aldehydes (6a-h) were synthesized from the corresponding acidchlorides (5a-d) using HSnBu(3).
authors.affiliation: Southern Methodist University, Department of, Chemistry, Dallas, TX, 75275.
authors.forename: Sukanta
authors.initials: S
authors.lastname: Kamila
authors.forename: Haribabu
authors.initials: H
authors.lastname: Ankati
authors.forename: Edward R
authors.initials: ER
authors.lastname: Biehl