title: Diet and IVF pilot study: short-term weight loss improves pregnancy rates in overweight/obese women undertaking IVF.
abstract: Obesity worsens and modest weight loss improves female fertility. Overweight women were randomised to lifestyle or standard treatment pre-in vitro fertilisation with treatment cessation at embryo transfer. There was a greater reduction in weight (P < 0.001) for lifestyle treatment (-3.8 ± 3.0 kg, P < 0.001) compared with no changes for standard treatment (-0.5 ± 1.2 kg, P = 0.092). Both the intervention (-5.3 ± 4.6 cm) and control (-3.5 ± 3.5 cm) group had reductions in waist circumference (P < 0.001) with no differences between the two groups (P = 0.215). The overall pregnancy rate was 53% (20/38) for the intervention and control group combined.
authors.affiliation: School of Paediatrics and Reproductive Health, Research Centre for Reproductive Health, The Robinson Institute, University of Adelaide, South Australia, Australia. lisa.moran@adelaide.edu.au
authors.forename: Lisa
authors.initials: L
authors.lastname: Moran
authors.forename: Victoria
authors.initials: V
authors.lastname: Tsagareli
authors.forename: Robert
authors.initials: R
authors.lastname: Norman
authors.forename: Manny
authors.initials: M
authors.lastname: Noakes
mesh_terms: D000328:Adult; D015992:Body Mass Index; D004038:Diet, Reducing; D015444:Exercise; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008019:Life Style; D009765:Obesity / Q000178:diet therapy*; D010865:Pilot Projects; D011247:Pregnancy; D018873:Pregnancy Rate; D055105:Waist Circumference; D015431:Weight Loss