title: Bone mineral density is related with previous renal dysfunction caused by cadmium exposure.
abstract: Relationship between bone mineral density (BMD) and previous renal dysfunction caused by cadmium exposure was investigated. A total of 457 persons, living in polluted and control areas, were followed up in this study. The inhabitants living in exposure areas ceased ingesting cadmium-contaminated rice in 1996. Blood and urinary cadmium levels and BMD in 1998 and 2006 were measured. Urinary N-acetyl-β-d-glucosaminidase and albumin determined in 1998 and 2006 were used to evaluate kidney status. BMD of subjects with tubular damage was significant lower than those without damage in female (p < 0.05). The prevalence of osteoporosis was significantly different between those with and without kidney damage (p = 0.003, in total population; p = 0.039, in female) and those with and without tubular damage (p = 0.0005, in total population; p = 0.007, in female). The results suggested that BMD was correlated with previous kidney impairment caused by cadmium exposure, especially to tubular damage and especially for female.
authors.affiliation: Department of Bone Metabolism, Institute of Radiation Medicine, Fudan University, Shanghai, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.forename: Guoying
authors.initials: G
authors.lastname: Zhu
authors.forename: Taiyi
authors.initials: T
authors.lastname: Jin
authors.forename: Lijian
authors.initials: L
authors.lastname: Lei
authors.forename: Yihuai
authors.initials: Y
authors.lastname: Liang
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000368:Aged; D000419:Albuminuria / Q000139:chemically induced / Q000378:metabolism; D015519:Bone Density; D002104:Cadmium / Q000097:blood / Q000633:toxicity* / Q000652:urine; D002681:China / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity* / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D005506:Food Contamination; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012275:Oryza; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D015995:Prevalence
chemical_list: D004785:Environmental Pollutants; D002104:Cadmium; D000118:Acetylglucosaminidase