title: -383 A/C tumor necrosis factor receptor 1 polymorphism and ankylosing spondylitis in Mexicans: a preliminary study.
abstract: The objective of this study was to evaluate the differences in allele and genotype frequencies of -383 tumor necrosis factor receptor 1 (TNFR1) polymorphism between ankylosing spondylitis (AS) and controls. Mexican Mestizos with AS were matched by gender, age, and ethnicity with healthy controls and compared in allele and genotype frequencies of the -383 TNFR1 polymorphism. Polymorphisms were genotyped using PCR-RFLP. The AA genotype occurred at a higher frequency in the AS group (92%) compared with controls (79%, P = 0.03). A allele was increased in AS (96% vs. 88%, P = 0.015) and was associated with genetic susceptibility for AS (odds ratio = 3.48, 95% CI = 1.23-10.61). This preliminary study is the first assessing the association of the -383 A/C TNFR1 polymorphism with AS, although it has the limitation of a small sample size. These data are of interest for the genetic epidemiology of AS in the Mexican population, requiring further investigation in other countries.
authors.affiliation: Clinical Epidemiology Research Unit, Section of Musculoskeletal Diseases and Autoimmunity, Hospital de Especialidades Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Belisario Domínguez No. 1000, Col. Independencia, Guadalajara, Mexico.
authors.forename: Esther Guadalupe
authors.initials: EG
authors.lastname: Corona-Sanchez
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Muñoz-Valle
authors.forename: Laura
authors.initials: L
authors.lastname: Gonzalez-Lopez
authors.forename: Julia Dolores
authors.initials: JD
authors.lastname: Sanchez-Hernandez
authors.forename: Monica
authors.initials: M
authors.lastname: Vazquez-Del Mercado
authors.forename: Heriberto
authors.initials: H
authors.lastname: Ontiveros-Mercado
authors.forename: Miguel
authors.initials: M
authors.lastname: Huerta
authors.forename: Xochitl
authors.initials: X
authors.lastname: Trujillo
authors.forename: Alberto Daniel
authors.initials: AD
authors.lastname: Rocha-Muñoz
authors.forename: Alfredo
authors.initials: A
authors.lastname: Celis
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ortega-Flores
authors.forename: Jorge Ivan
authors.initials: JI
authors.lastname: Gamez-Nava
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology
chemical_list: D047888:Receptors, Tumor Necrosis Factor, Type I; C506235:TNFRSF1A protein, human