title: Epistasis: the key to understanding immunological disease?
abstract: Epistasis is fast becoming central to the understanding of the complex relationship between genotype and phenotype observed in autoimmune disease. A study in this issue of the European Journal of Immunology uses in-depth analysis of genome-wide mapping by polymorphic microsatellite markers to shed light on the genomic control of autoimmunity and self-tolerance.
authors.affiliation: Department of Genetics, UCL Institute of Ophthalmology, London, UK.
authors.forename: N Avrion
authors.initials: NA
authors.lastname: Mitchison
authors.forename: Anna M
authors.initials: AM
authors.lastname: Rose
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology*; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D002417:Cattle; D004843:Epistasis, Genetic; D020022:Genetic Predisposition to Disease; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D011956:Receptors, Cell Surface / Q000235:genetics / Q000276:immunology*; D017452:Receptors, IgG / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D005719:gamma-Globulins / Q000008:administration & dosage / Q000276:immunology
chemical_list: D015703:Antigens, CD; C499172:Fcgr2b protein, mouse; D011956:Receptors, Cell Surface; D017452:Receptors, IgG; D005719:gamma-Globulins; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1