title: Abnormalities of the exercise pressor reflex in heart failure.
abstract: Abnormal cardiovascular responses to exercise in heart failure contribute significantly to the morbidity and mortality in the patient population. These abnormal responses may be the result of peripheral impairment in the skeletal muscle and the neurons that innervate the muscle. We present the current literature on the role of muscle afferents in regulating the cardiovascular responses to exercise in cardiomyopathy.
authors.affiliation: Department of Medicine, Division of Hematology, Oncology and Transplantation, Lillehei Heart Institute, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, USA. garry002@umn.edu
authors.forename: Mary G
authors.initials: MG
authors.lastname: Garry
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002211:Capsaicin; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology; D015536:Down-Regulation; D015444:Exercise / Q000502:physiology*; D005682:Gadolinium; D006333:Heart Failure / Q000378:metabolism / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology*; D043882:Receptors, Cannabinoid / Q000378:metabolism; D018689:Sensory System Agents; D050916:TRPV Cation Channels / Q000378:metabolism
chemical_list: D043882:Receptors, Cannabinoid; D018689:Sensory System Agents; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D005682:Gadolinium; D002211:Capsaicin