title: Influencing mucosal homeostasis and immune responsiveness: the impact of nutrition and pharmaceuticals.
abstract: Both nutrition and orally ingested drugs pass the gastrointestinal mucosa and may affect the balance between the mucosal immune system and microbial community herein, i.e. affecting composition of the microbial community as well as the status of local immune system that controls microbial composition and maintains mucosal integrity. Numerous ways are known by which the microbial community stimulates mammalian host's immune system and vice versa. The communication between microbiota and immune system is principally mediated by interaction of bacterial components with pattern recognition receptors expressed by intestinal epithelium and various local antigen-presenting cells, resulting in activation or modulation of both innate and adaptive immune responses. Current review describes some of the factors influencing development and maintenance of a proper mucosal/immune balance, with special attention to Toll like receptor signaling and regulatory T cell development. It further describes examples (antibiotic use, HIV and asthma will be discussed) showing that disruption of the balance can be linked to immune function failure. The therapeutic potential of nutritional pharmacology herein is the main focus of discussion.
authors.affiliation: Department of Pediatrics, The Wilhelmina Children's Hospital, University Medical Center, Utrecht, the Netherlands. Belinda.vantLand@Danone.com
authors.forename: Belinda
authors.initials: B
authors.lastname: van't Land
authors.forename: Marcel A
authors.initials: MA
authors.lastname: Schijf
authors.forename: Rocio
authors.initials: R
authors.lastname: Martin
authors.forename: Johan
authors.initials: J
authors.lastname: Garssen
authors.forename: Grada M
authors.initials: GM
authors.lastname: van Bleek
mesh_terms: D000818:Animals; D005502:Food; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000276:immunology / Q000382:microbiology / Q000502:physiology*; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D054892:Metagenome / Q000187:drug effects / Q000502:physiology; D009092:Mucous Membrane / Q000187:drug effects / Q000276:immunology / Q000382:microbiology / Q000502:physiology