title: Persistent pulmonary hypertension of the newborn in twin-twin transfusion syndrome following fetoscopic laser surgery.
abstract: OBJECTIVE
  We investigated persistent pulmonary hypertension of the newborn (PPHN) among monochorionic-diamniotic (MD) twins.
  
  
  METHODS
  A retrospective cohort study examined MD twins from 195 deliveries and 373 live-born neonates at our center.
  
  
  RESULTS
  PPHN occurred in three cases (3/373: 0.8%), all of which were recipients of twin-twin transfusion syndrome (TTTS), after fetoscopic laser surgery (FLS) (3/117: 2.6%). Although the clinical course of the three cases differed, all cardiothoracic area ratios exceeded 40%, and other cardiac parameters also worsened after FLS.
  
  
  CONCLUSIONS
  The occurrence of PPHN in TTTS recipients should be noted, particularly when fetal cardiac function declines following FLS.
authors.affiliation: Department of Maternal-Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Takahashi
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takahashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: Yushi
authors.initials: Y
authors.lastname: Ito
authors.forename: Tomoo
authors.initials: T
authors.lastname: Nakamura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayashi
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sago
mesh_terms: D000328:Adult; D015331:Cohort Studies; D045462:Endothelium-Dependent Relaxing Factors / Q000627:therapeutic use; D005260:Female; D005330:Fetofetal Transfusion / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D005332:Fetoscopy; D006801:Humans; D007231:Infant, Newborn; D053685:Laser Therapy; D008297:Male; D009569:Nitric Oxide / Q000627:therapeutic use; D010547:Persistent Fetal Circulation Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D011247:Pregnancy; D012189:Retrospective Studies; D014430:Twins, Monozygotic
chemical_list: D045462:Endothelium-Dependent Relaxing Factors; D009569:Nitric Oxide