title: Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: a meta-analysis, 1985-2010.
abstract: Human papillomavirus (HPV) types 16 and 18 are causally related to a sub-set of oral cavity and oropharyngeal squamous cell cancers. However, a clear estimate of the prevalence of HPV-16/18 in oral cavity and oropharyngeal dysplasia (OOPD) is not available. This literature review and meta-analysis was conducted to provide a prevalence estimate for HPV-16/18 in OOPD. Twenty-two studies that reported prevalence of HPV-16 and/or 18 in 458 OOPD lesions were analyzed. Meta-analysis was used to evaluate the prevalence of HPV-16/18 and logistic regression was used for stratified analysis by age, gender, and histological grade. The overall prevalence of HPV-16/18 in OOPD lesions was 24.5% [95% confidence interval (CI), 16.4-36.7%)]. The individual prevalence for HPV-16 alone was 24.4%. The prevalence of HPV-16/18 in oral cavity lesions alone was 25.3% (95% CI, 14.2-45.2%). The odds of detection of HPV-16/18 in dysplastic lesions in males were twice that of females [odds ratio (OR), 2.44]. HPV-16/18 were 3 times more common in dysplastic lesions (OR, 3.29; 95% CI, 1.95-5.53%) and invasive cancers (OR, 3.43; 95% CI, 2.07-5.69%), when compared to normal biopsies. There was no significant difference in HPV-16/18 rates between dysplastic lesions and cancers or between mild, moderate or severe dysplastic lesions. This meta-analysis provides a quantification of the prevalence of HPV types 16/18 in OOPD lesions. These results also support the assumption that HPV-16/18 infection occurs during the early phase of the oral cavity and oropharyngeal carcinogenesis.
authors.affiliation: Department of Dentistry and MFP, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. vijay.jayaprakash@roswellpark.org
authors.forename: Vijayvel
authors.initials: V
authors.lastname: Jayaprakash
authors.forename: Mary
authors.initials: M
authors.lastname: Reid
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hatton
authors.forename: Mihai
authors.initials: M
authors.lastname: Merzianu
authors.forename: Nestor
authors.initials: N
authors.lastname: Rigual
authors.forename: James
authors.initials: J
authors.lastname: Marshall
authors.forename: Steve
authors.initials: S
authors.lastname: Gill
authors.forename: Jennifer
authors.initials: J
authors.lastname: Frustino
authors.forename: Gregory
authors.initials: G
authors.lastname: Wilding
authors.forename: Thom
authors.initials: T
authors.lastname: Loree
authors.forename: Saurin
authors.initials: S
authors.lastname: Popat
authors.forename: Maureen
authors.initials: M
authors.lastname: Sullivan
mesh_terms: D000367:Age Factors; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000821:virology*; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D052161:Human papillomavirus 18 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000821:virology*; D016017:Odds Ratio; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000821:virology*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors