title: New strategies in diffuse large B-cell lymphoma: translating findings from gene expression analyses into clinical practice.
abstract: Gene expression profiling has had a major impact on our understanding of the biology and heterogeneity of diffuse large B-cell lymphoma (DLBCL). Using this technology, investigators can identify biologic subgroups of DLBCL that provide unique targets for rational therapeutic intervention. This review summarizes these potential targets and updates the progress of clinical development of exciting novel agents for the treatment of DLBCL. Results of ongoing studies suggest that in the near future, we will be able to use gene expression profiling, or an accurate surrogate, to define the best therapeutic approach for individual patients with DLBCL.
authors.affiliation: University of Rochester Medical Center, Rochester, New York 14642, USA. jonathan_friedberg@urmc.rochester.edu
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Friedberg
mesh_terms: D020869:Gene Expression Profiling; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy* / Q000235:genetics*; D058990:Molecular Targeted Therapy; D011379:Prognosis; D011493:Protein Kinase C / Q000235:genetics; D064546:Protein Kinase C beta; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D011493:Protein Kinase C; D064546:Protein Kinase C beta