title: Myrrh inhibits LPS-induced inflammatory response and protects from cecal ligation and puncture-induced sepsis.
abstract: Myrrh has been used as an antibacterial and anti-inflammatory agent. However, effect of myrrh on peritoneal macrophages and clinically relevant models of septic shock, such as cecal ligation and puncture (CLP), is not well understood. Here, we investigated the inhibitory effect and mechanism(s) of myrrh on inflammatory responses. Myrrh inhibited LPS-induced productions of inflammatory mediators such as nitric oxide, prostaglandin E(2), and tumor necrosis factor-α but not of interleukin (IL)-1β and IL-6 in peritoneal macrophages. In addition, Myrrh inhibited LPS-induced activation of c-jun NH(2)-terminal kinase (JNK) but not of extracellular signal-regulated kinase (ERK), p38, and nuclear factor-κB. Administration of Myrrh reduced the CLP-induced mortality and bacterial counts and inhibited inflammatory mediators. Furthermore, administration of Myrrh attenuated CLP-induced liver damages, which were mainly evidenced by decreased infiltration of leukocytes and aspartate aminotransferase/alanine aminotransferase level. Taken together, these results provide the evidence for the anti-inflammatory and antibacterial potential of Myrrh in sepsis.
authors.affiliation: Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 540-749, Republic of Korea.
authors.forename: Min-Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Gi-Sang
authors.initials: GS
authors.lastname: Bae
authors.forename: Kyoung-Chel
authors.initials: KC
authors.lastname: Park
authors.forename: Bon Soon
authors.initials: BS
authors.lastname: Koo
authors.forename: Byung-Jin
authors.initials: BJ
authors.lastname: Kim
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Sang-Wan
authors.initials: SW
authors.lastname: Seo
authors.forename: Yong Kook
authors.initials: YK
authors.lastname: Shin
authors.forename: Won-Seok
authors.initials: WS
authors.lastname: Jung
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Cho
authors.forename: Youn-Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Tae-Hyeon
authors.initials: TH
authors.lastname: Kim
authors.forename: Ho-Joon
authors.initials: HJ
authors.lastname: Song
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Park