title: The use of umbelliferone in the synthesis of new heterocyclic compounds.
abstract: New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one, 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one, 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide, 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one and 7-[(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy]-2H-chromen-2-one were prepared starting from the natural compound umbelliferone. The newly synthesized compounds were characterized by elemental analysis and spectral studies (IR, ¹H-NMR and ¹³C-NMR).
authors.affiliation: Department of Chemical and Processing Engineering, Faculty of Engineering and Built Environment, University of Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia. dr.ahmed@eng.ukm.my
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Al-Amiery
authors.forename: Ahmed Y
authors.initials: AY
authors.lastname: Musa
authors.forename: Abdul Amir H
authors.initials: AA
authors.lastname: Kadhum
authors.forename: Abu Bakar
authors.initials: AB
authors.lastname: Mohamad
mesh_terms: D000085:Acetates / Q000737:chemistry; D001688:Biological Products / Q000032:analysis / Q000138:chemical synthesis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006842:Hydrocarbons, Brominated / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D012663:Semicarbazides / Q000737:chemistry; D013816:Thermodynamics; D013830:Thiadiazoles / Q000737:chemistry; D014468:Umbelliferones / Q000032:analysis / Q000138:chemical synthesis
chemical_list: D000085:Acetates; D001688:Biological Products; D006842:Hydrocarbons, Brominated; D012663:Semicarbazides; D013830:Thiadiazoles; D014468:Umbelliferones; C058949:1,3,4-thiadiazole; C005151:thiosemicarbazide; C010144:ethyl bromoacetate