title: Association between lipoprotein(a) and oxygen reactive metabolite in asymptomatic subjects.
abstract: BACKGROUND
  Lipoprotein(a) [Lp(a)] is generally considered a risk factor for cardiovascular disease (CVD). The coexistence of Lp(a) and oxidative status may be associated with the pathophysiology of the Lp(a)-CVD linkage.
  
  
  OBJECTIVE
  The aim of the present study was to investigate the correlation between Lp(a) and oxidative status using the diacron Reactive Oxygen Metabolite (d-ROM) test as an oxidative stress-related marker in asymptomatic subjects.
  
  
  METHODS
  The serum levels of Lp(a) and d-ROM were measured in 322 subjects (male/female 138/184; mean age 58.5 years) in addition to body mass index, blood pressure, glycemia, and lipid profile.
  
  
  RESULTS
  The median levels of Lp(a) were 14.6 mg/dl (interquartile range 6.7-30.3) and the mean levels of d-ROM were 332 ± 67 U. Carr. A simple linear regression analysis showed that the d-ROM level was significantly and positively correlated with Lp(a) (correlation coefficient = 0.22, P <0.01). Multivariate-adjusted analyses confirmed this weak but significant correlation, independent of confounding variables. This correlation appeared to be relatively stronger in men than in women.
  
  
  CONCLUSIONS
  A positive correlation between Lp(a) and oxidative status, as assessed by d-ROM, in this population may be partially associated with the Lp(a)-CVD relationship.
authors.affiliation: Department of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Japan. kazukotani@jichi.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.forename: Naoki
authors.initials: N
authors.lastname: Sakane
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D017270:Lipoprotein(a); D017382:Reactive Oxygen Species