title: On rare and "super-rare" diseases: an insight from the Republic of Macedonia.
abstract: Rare diseases (RD) are becoming increasingly important as possible targets of new forms of treatment, as a valuable source of a novel insight in fundamental lows of biology, and in the specific mechanisms of many diseases. Molecular methods have created a better diagnosis and oftentimes treatment. RDs pose significant problem for the patients, since their problems are often not recognized by the medical community and shunned by the health insurance. The cumulative costs of diagnosis and treatment of RDs is significant for any society, oftentimes bearably acceptable for developing countries.
authors.affiliation: Medical Faculty, Skopje, R. Macedonia.
authors.forename: Z S
authors.initials: ZS
authors.lastname: Gucev
authors.forename: V
authors.initials: V
authors.lastname: Tasic
authors.forename: M
authors.initials: M
authors.lastname: Polenakovic
mesh_terms: D003951:Diagnostic Errors / Q000517:prevention & control*; D061345:Early Medical Intervention / Q000458:organization & administration; D006295:Health Resources / Q000458:organization & administration; D006801:Humans; D009965:Orphan Drug Production; D010346:Patient Care Management / Q000379:methods*; D035583:Rare Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D018843:Republic of North Macedonia; D009626:Terminology as Topic