title: Old world Leishmania infantum cutaneous leishmaniasis unresponsive to liposomal amphotericin B treated with topical imiquimod.
abstract: We present a case of a child with Leishmania infantum cutaneous leishmaniasis unresponsive to 2 courses of intravenous liposomal amphotericin B, a treatment failure that has not been reported in this Leishmania species. The patient responded to topical imiquimod and had no relapse. We review the literature on the treatment failure of liposomal amphotericin B for cutaneous leishmaniasis.
authors.affiliation: Section of Pediatric Infectious Diseases, IUNICS, Son Espases University Hospital and University of the Balearic Islands, Palma de Mallorca, The Balearic Islands, Spain. jhervashp@yahoo.es
authors.forename: Juan A
authors.initials: JA
authors.lastname: Hervás
authors.forename: Ana
authors.initials: A
authors.lastname: Martín-Santiago
authors.forename: Daniel
authors.initials: D
authors.lastname: Hervás
authors.forename: Estrella
authors.initials: E
authors.lastname: Rojo
authors.forename: Ana
authors.initials: A
authors.lastname: Mena
authors.forename: Vicente
authors.initials: V
authors.lastname: Rocamora
authors.forename: Joaquín
authors.initials: J
authors.lastname: Dueñas
mesh_terms: D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage*; D000666:Amphotericin B / Q000008:administration & dosage*; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage*; D002648:Child; D006801:Humans; D000077271:Imiquimod; D018314:Leishmania infantum / Q000187:drug effects*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000469:parasitology; D008081:Liposomes / Q000008:administration & dosage*; D008297:Male; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D000981:Antiprotozoal Agents; D008081:Liposomes; D000666:Amphotericin B; D000077271:Imiquimod