title: Anatomy and development of the craniovertebral junction.
abstract: The occipital bone is the upper end of the somatic spine, limited cranially by the tentorium. The bony craniovertebral junction (caudal occiput, atlas, and axis) is interposed between the unsegmented occipital and the intersegmental spinal sclerotomes, separated from the occiput and C3 by the intrasegmental clefts of O4 and C2 sclerotomes, respectively. It retains a primitive segmental hypocentrum (anterior arch of C1) and is unsegmented from caudal O4 to cranial C2 half-sclerotomes (axis). Its morphology relates to the dual function of providing support and mobility (visual/olfactory/auditory pursuit, oral prehension) to the head. The early notochord passes through the odontoid tip to the basiocciput surface before entering the clivus up to the craniopharyngeal canal; later, the rostralmost chordal remnant is the C2/3 nucleus pulposus. Chondrification starts in the second fetal month and ossification in the fetal or postnatal periods depending on the structure.
authors.affiliation: Department of Neuroradiology, Hospital for Sick Children, University of Toronto, Toronto, ON, M5G1X8, Canada. charles.raybaud@sickkids.ca
authors.forename: Charles
authors.initials: C
authors.lastname: Raybaud
mesh_terms: D001268:Atlanto-Axial Joint / Q000033:anatomy & histology* / Q000254:growth & development*; D001269:Atlanto-Occipital Joint / Q000033:anatomy & histology* / Q000254:growth & development*; D001270:Cervical Atlas / Q000033:anatomy & histology* / Q000254:growth & development*; D006801:Humans