title: Vibrio anguillarum as a fish pathogen: virulence factors, diagnosis and prevention.
abstract: Vibrio anguillarum, also known as Listonella anguillarum, is the causative agent of vibriosis, a deadly haemorrhagic septicaemic disease affecting various marine and fresh/brackish water fish, bivalves and crustaceans. In both aquaculture and larviculture, this disease is responsible for severe economic losses worldwide. Because of its high morbidity and mortality rates, substantial research has been carried out to elucidate the virulence mechanisms of this pathogen and to develop rapid detection techniques and effective disease-prevention strategies. This review summarizes the current state of knowledge pertaining to V. anguillarum, focusing on pathogenesis, known virulence factors, diagnosis, prevention and treatment.
authors.affiliation: Laboratory for Process Microbial Ecology and Bioinspirational Management, Consortium for Industrial Microbiology and Biotechnology, Department of Microbial and Molecular Systems, K.U. Leuven Association, Lessius Mechelen, Sint-Katelijne-Waver, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Frans
authors.forename: C W
authors.initials: CW
authors.lastname: Michiels
authors.forename: P
authors.initials: P
authors.lastname: Bossier
authors.forename: K A
authors.initials: KA
authors.lastname: Willems
authors.forename: B
authors.initials: B
authors.lastname: Lievens
authors.forename: H
authors.initials: H
authors.lastname: Rediers
mesh_terms: D000818:Animals; D005393:Fish Diseases / Q000175:diagnosis* / Q000382:microbiology* / Q000517:prevention & control*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D007501:Iron / Q000378:metabolism; D008070:Lipopolysaccharides; D008854:Microscopy, Electron; D053038:Quorum Sensing / Q000502:physiology*; D017262:Siderophores / Q000378:metabolism; D014733:Vibrio / Q000472:pathogenicity* / Q000648:ultrastructure; D014735:Vibrio Infections / Q000175:diagnosis / Q000517:prevention & control / Q000662:veterinary*; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D008070:Lipopolysaccharides; D017262:Siderophores; D037521:Virulence Factors; D007501:Iron