title: Combination therapy with an endothelin-1 receptor antagonist (bosentan) and a phosphodiesterase V inhibitor (sildenafil) for the management of severe digital ulcerations in systemic sclerosis.
authors.affiliation: Department for Dermatology and Venerology, University of Cologne, Cologne, Germany. Electronic address: pia.moinzadeh@uk-koeln.de.
authors.forename: Pia
authors.initials: P
authors.lastname: Moinzadeh
authors.affiliation: Department for Dermatology and Venerology, University of Cologne, Cologne, Germany.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Hunzelmann
authors.affiliation: Department for Dermatology and Venerology, University of Cologne, Cologne, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Krieg
mesh_terms: D000077300:Bosentan; D004359:Drug Therapy, Combination; D065130:Endothelin A Receptor Antagonists; D005385:Fingers; D006801:Humans; D008297:Male; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors / Q000008:administration & dosage*; D010879:Piperazines / Q000008:administration & dosage*; D011687:Purines / Q000008:administration & dosage; D012595:Scleroderma, Systemic / Q000150:complications*; D000068677:Sildenafil Citrate; D012883:Skin Ulcer / Q000150:complications / Q000188:drug therapy*; D013449:Sulfonamides / Q000008:administration & dosage*; D013450:Sulfones / Q000008:administration & dosage*
chemical_list: D065130:Endothelin A Receptor Antagonists; D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D013449:Sulfonamides; D013450:Sulfones; D000068677:Sildenafil Citrate; D000077300:Bosentan