title: Activity against Streptococcus pneumoniae of the essential oil and 5-(3-buten-1-ynyl)-2, 2'-bithienyl isolated from Chrysactinia mexicana roots.
abstract: The essential oil of Chrysactinia mexicana retrieved from the root bark was characterized by gas chromatography coupled to a mass detector. The compounds silphiperfol-5-ene, 7-epi- silphiperfol-5-ene, modheph-2-ene, alpha-isocomene, beta-isocomene and methyl-linoleate were identified. The principal compound (76.42%) could not be identified by the library and was further isolated through a reverse phase C-18 chromatography followed by silica gel chromatography and identified as 5-(3-buten-1-ynyl)-2,2'-bithienyl. Both the oil and the isolated compound were tested for their antimicrobial activity against two strains of Streptococcus pneumoniae resistant to beta-lactam antibiotics. MICs were 250 microg/mL and 125 microg/mL respectively. This is the first report about extraction of oil and compound 5-(3-buten-1-ynyl)-2, 2'-bithienyl from roots of Chrysactinia mexicana as well as the determination of antimicrobial activity against S. pneumoniae.
authors.affiliation: Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Departamento de Química, Av. Pedro de Albay Manuel L. Barragán s/n, Cd. Universitaria, C.P. 66451, San Nicolás de los Garza, Nuevo León, México.
authors.forename: Bárbara Missiam Mezari
authors.initials: BM
authors.lastname: Guevara Campos
authors.forename: Anabel
authors.initials: A
authors.lastname: Torres Cirio
authors.forename: Verónica Mayela
authors.initials: VM
authors.lastname: Rivas Galindo
authors.forename: Ricardo
authors.initials: R
authors.lastname: Salazar Aranda
authors.forename: Noemí
authors.initials: N
authors.lastname: Waksman de Torres
authors.forename: Luis Alejandro
authors.initials: LA
authors.lastname: Pérez-López
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D008800:Mexico; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013876:Thiophenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile; D010938:Plant Oils; D013876:Thiophenes