title: [Effect of a simulated He-O2 saturation dive to 65 msw on oxidative stress in humans].
abstract: OBJECTIVE
  To investigate whether a simulated He-O2 saturation dive to 65 msw would affect oxidative balance in humans.
  
  
  METHODS
  Seven divers participated in a simulated saturation dive to 0.75 MPa (65 msw). 24-h urine samples were collected twice before, twice during, and twice after the dive, then were analyzed for contents of superoxide dismutase (SOD), malondialdehyde (MDA), total amino acid (T-AA) and total anti-oxidant capacity (T-AOC). Meanwhile, total urine volume and body weight were measured.
  
  
  RESULTS
  The content of T-AA was higher. (P < 0.05) than the base value in final decompression, but reverse to normal at one week after decompression. There were no changes in contents of SOD, MDA and T-AOC during and after the dive compared with their basic value. Total urine volume was lower (P < 0.05, vs basic value) at first day in chamber, then returned to normal. Body weight gradually increased after compression till the end of decompression (higher than basic value, P < 0.05).
  
  
  CONCLUSIONS
  These data indicate that simulated saturation dive to 65 msw may not induce obvious oxidative damage, but it is necessary to monitor 24-h urine volume and oxidative sress by time in order to prevent from tissue injury.
authors.affiliation: Naval Medical Research Institute, Shanghai 200433, China.
authors.forename: Ci
authors.initials: C
authors.lastname: Li
authors.forename: Jia
authors.initials: J
authors.lastname: He
authors.forename: Min-Hang
authors.initials: MH
authors.lastname: Liu
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Liu
authors.forename: Heng-Rong
authors.initials: HR
authors.lastname: Yuan
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Yi-Qun
authors.initials: YQ
authors.lastname: Fang
authors.forename: Wei-Bing
authors.initials: WB
authors.lastname: Xiao
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000652:urine; D003664:Decompression; D004242:Diving / Q000502:physiology*; D006371:Helium / Q000737:chemistry; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000652:urine; D018384:Oxidative Stress / Q000502:physiology*; D010100:Oxygen / Q000009:adverse effects* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D006371:Helium; D008315:Malondialdehyde; D010100:Oxygen