title: Surprise! HSC are aberrant in chronic lymphocytic leukemia.
abstract: In this issue of Cancer Cell, Kikushige et al. report the surprising finding that, in human chronic lymphocytic leukemia (CLL), hematopoietic stem cells (HSC) aberrantly generate clonal B cells with CLL-like phenotypes, which implicate HSC in the pathogenesis of this mature lymphoid malignancy and has major implications for CLL therapies.
authors.affiliation: Institute for Stem Cell Biology and Regenerative Medicine, Cancer Institute, and Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. arasha@stanford.edu
authors.forename: Ash A
authors.initials: AA
authors.lastname: Alizadeh
authors.forename: Ravindra
authors.initials: R
authors.lastname: Majeti