title: Trace detection of hormones and sulfonamides in viscous cosmetic products by neutral desorption extractive electrospray ionization tandem mass spectrometry.
abstract: A sensitive method based on a geometry-independent neutral desorption (GIND) in combination with extractive electrospray ionization mass spectrometry (EESI-MS) has been developed for fast detection of illicit additives such as sulfonamides and hormones in highly viscous cosmetic products. The method gave a low limit of detection (LOD) (in the range of 0.001-1 ng/g), acceptable relative standard deviation (RSD=6.8-11.4%) and reasonable recovery (87-116%) for direct measuring of nine types of hormones and sulfonamides in the cosmetic products. The average measurement time for two types of samples was less than 1 min. Trace amounts of analytes in commercial cosmetic products have been quantitatively detected, without any sample pretreatment. The experimental results showed that non-volatile illicit additives such as sulfonamides and hormones could be sensitively liberated using the GIND device for quantitative detection from the highly viscous cosmetic products, demonstrating that GIND-EESI-MS is a promising tool for high throughput, sensitive and quantitative analysis of highly complex viscous samples.
authors.affiliation: Beijing Center for Physical and Chemical Analysis, Beijing 100089, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Xinglei
authors.initials: X
authors.lastname: Zhang
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Ouyang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Hu
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Jinghua
authors.initials: J
authors.lastname: Zhang
authors.forename: Jinming
authors.initials: J
authors.lastname: Lin
authors.forename: Huanwen
authors.initials: H
authors.lastname: Chen
mesh_terms: D003358:Cosmetics / Q000737:chemistry*; D057166:High-Throughput Screening Assays; D006728:Hormones / Q000032:analysis*; D011312:Pressure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013449:Sulfonamides / Q000032:analysis*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D013696:Temperature; D014783:Viscosity
chemical_list: D003358:Cosmetics; D006728:Hormones; D013449:Sulfonamides