title: Prevalence of adrenal haemorrhage in non-surviving patients with burns.
abstract: OBJECTIVE
  The purpose of this study was to investigate the prevalence of adrenal haemorrhage (AH) in non-surviving patients with severe burns by combining the clinical notes and autopsy data.
  
  
  METHODS
  A retrospective review of all adult (age >18 years) burn patients who died in the Helsinki Burn Centre, Helsinki, Finland during 1.1.1995 to 31.12.2005 was conducted. Patients diagnosed with AH either in the clinical charts or in the autopsy reports were sorted out. Special attention was paid to the course of events preceding death and autopsy findings.
  
  
  RESULTS
  We identified four patients, creating a prevalence of 5.6%. None of the patients was diagnosed with AH alive. Three patients we diagnosed with bilateral AH, all young men. Cause of death was multiple organ failure (MOF) in all three cases. On the autopsy, they were diagnosed with 5±1 organ failures. One case of unilateral AH was established, an elderly male with hot air sauna burns. Clinical charts and autopsy data suggest idiopathic AH.
  
  
  CONCLUSIONS
  The prevalence of AH is higher than previously estimated in non-surviving patients with burns. Bilateral AH occurred later then 1 week after the burn trauma. Bilateral AH always presented with sepsis, multiple organ failure and acute renal failure.
authors.affiliation: Department of Plastic Surgery, Helsinki University Hospital, Helsinki, Finland. outi.kallinen@helsinki.fi
authors.forename: Outi
authors.initials: O
authors.lastname: Kallinen
authors.forename: Virve
authors.initials: V
authors.lastname: Koljonen
mesh_terms: D000307:Adrenal Gland Diseases / Q000150:complications / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D001344:Autopsy; D002056:Burns / Q000150:complications* / Q000401:mortality; D005260:Female; D005387:Finland / Q000453:epidemiology; D006470:Hemorrhage / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000401:mortality; D015995:Prevalence; D012189:Retrospective Studies; D016019:Survival Analysis