title: Combination therapy of low-fluence photodynamic therapy and intravitreal ranibizumab for choroidal neovascular membrane in choroidal osteoma.
abstract: Choroidal osteoma is an unusual form of intraocular calcification seen in otherwise healthy eyes. It is a benign idiopathic osseous tumor of the choroid, typically seen in young females. Choroidal neovascular membrane (CNVM) is a complication seen in one-third of these patients and carries a poor visual outcome. We report a case of a 25-year-old hyperthyroid female with choroidal osteoma and subfoveal CNVM in her left eye which was successfully treated using low-fluence photodynamic therapy (PDT) with verteporfin followed by a single injection of intravitreal ranibizumab.
authors.affiliation: Department of Retina and Vitreous, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore - 641 014, Tamilnadu, India. rodneyjmorris@gmail.com
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Morris
authors.forename: Varsha V
authors.initials: VV
authors.lastname: Prabhu
authors.forename: Parag K
authors.initials: PK
authors.lastname: Shah
authors.forename: V
authors.initials: V
authors.lastname: Narendran
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D002830:Choroid Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D058449:Intravitreal Injections; D033401:Microscopy, Acoustic; D010016:Osteoma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D010778:Photochemotherapy / Q000379:methods*; D000069579:Ranibizumab; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000069579:Ranibizumab