title: A case of ulcerative colitis accompanied with myelodysplastic syndrome successfully treated by cyclosporine.
abstract: A 64-year-old man had been admitted to a previous hospital because of melena and a diagnosis of ulcerative colitis (UC, pancolitis type) had been made. He had received prednisolone and 5-ASA but steroid-induced hyperamylasemia had developed. Prednisolone had been tapered and halted, but it had resulted in UC relapse and thrombocytopenia. Then, he was referred to our hospital due to severe melena with hypovolemic shock. However, he was also positive for CMV antigen. Thus, we attempted to treat him with ganciclovir for CMV and intravenous cyclosporine (CsA) for UC. According to his clinical course, a reduction of CsA blood concentration induced leukocytopenia. Myelodysplastic syndrome (MDS, RAEB-1) was then revealed after bone marrow biopsy. A high blood CsA concentration may cause the improvement of UC and MDS conditions.
authors.affiliation: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine. sho@sapmed.ac.jp
authors.forename: Sho
authors.initials: S
authors.lastname: Takahashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sato
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sagawa
authors.forename: Shingo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Murase
authors.forename: Kohichi
authors.initials: K
authors.lastname: Takada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iyama
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Rishu
authors.initials: R
authors.lastname: Takimoto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobune
authors.forename: Ganji
authors.initials: G
authors.lastname: Kuroiwa
authors.forename: Michiaki
authors.initials: M
authors.lastname: Hirayama
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Okamoto
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
mesh_terms: D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D016572:Cyclosporine / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000188:drug therapy*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine