title: Evaluation of cytogenotoxic effects of cold aqueous extract from Achyrocline satureioides by Allium cepa L test.
abstract: Achyrocline satureioides ("marcela del campo") is native to America. Numerous investigations have reported several bioactive properties such as anti-inflammatory, hepatoprotective, immunomodulatory, antimicrobial and antiviral. Nowadays, few medicinal plants have been scientifically evaluated to test its safety, efficacy and potential benefits, despite the great public interest in these herbs. The aim of this work was to evaluate the cytotoxic and genotoxic activities of cold aqueous extract obtained from A. satureioides using Allium cepa L test. The results demonstrated the absence of genotoxicity of the extract. Only higher concentrations induced cytotoxicity but interestingly this effect was reversible and was not associated with mutagenicity. The contribution of this research provides assurance of safety in the application of Achyrocline satureioides in treatment of microbial diseases and other pathologies helping to define selective toxicity.
authors.affiliation: Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, Córdoba, Argentina. csabini@exa.unrc.edu.ar
authors.forename: María C
authors.initials: MC
authors.lastname: Sabini
authors.forename: Laura N
authors.initials: LN
authors.lastname: Cariddi
authors.forename: Franco M
authors.initials: FM
authors.lastname: Escobara
authors.forename: Romina A
authors.initials: RA
authors.lastname: Bachetti
authors.forename: Sonia B
authors.initials: SB
authors.lastname: Sutil
authors.forename: Marta S
authors.initials: MS
authors.lastname: Contigiani
authors.forename: Silvia M
authors.initials: SM
authors.lastname: Zanon
authors.forename: Liliana I
authors.initials: LI
authors.lastname: Sabini
mesh_terms: D036921:Achyrocline / Q000737:chemistry*; D002869:Chromosome Aberrations / Q000139:chemically induced*; D003080:Cold Temperature; D008940:Mitotic Index; D019697:Onions / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development / Q000648:ultrastructure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity*; D018517:Plant Roots / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000648:ultrastructure; D014867:Water / Q000737:chemistry
chemical_list: D010936:Plant Extracts; D014867:Water