title: A chemical arms race at sea mediates algal host-virus interactions.
abstract: Despite the critical importance of viruses in shaping marine microbial ecosystems and lubricating upper ocean biogeochemical cycles, relatively little is known about the molecular mechanisms mediating phytoplankton host-virus interactions. Recent work in algal host-virus systems has begun to shed novel insight into the elegant strategies of viral infection and subcellular regulation of cell fate, which not only reveal tantalizing aspects of viral replication and host resistance strategies but also provide new diagnostic tools toward elucidating the impact of virus-mediated processes in the ocean. Widespread lateral gene transfer between viruses and their hosts plays a prominent role in host-virus diversification and in the regulation of host-virus infection mechanisms by allowing viruses to manipulate and 'rewire' host metabolic pathways to facilitate infection.
authors.affiliation: Environmental Biophysics and Molecular Ecology Group, Institute of Marine and Coastal Sciences, Rutgers University, New Brunswick, NJ 08901, USA. bidle@marine.rutgers.edu
authors.forename: Kay D
authors.initials: KD
authors.lastname: Bidle
authors.forename: Assaf
authors.initials: A
authors.lastname: Vardi
mesh_terms: D015415:Biomarkers; D020169:Caspases / Q000378:metabolism; D016923:Cell Death; D004789:Enzyme Activation; D005068:Eutrophication; D022761:Gene Transfer, Horizontal; D005814:Genes, Viral; D006028:Glycosphingolipids / Q000737:chemistry; D058087:Haptophyta / Q000737:chemistry / Q000235:genetics / Q000821:virology; D054884:Host-Pathogen Interactions; D009792:Oceans and Seas; D017862:Phycodnaviridae / Q000737:chemistry* / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology; D010839:Phytoplankton / Q000737:chemistry / Q000235:genetics / Q000821:virology*; D014779:Virus Replication; D014871:Water Microbiology
chemical_list: D015415:Biomarkers; D006028:Glycosphingolipids; D020169:Caspases