title: Case of metastatic pulmonary carcinoma in optic disc diagnosed from results of biopsy performed during vitrectomy surgery.
abstract: BACKGROUND
  Most intraocular metastatic tumors occur in the uveal tract, while isolated metastasis to the optic nerve is rarely found. We report a case of metastasis to the optic disc from primary lung cancer, diagnosed from biopsy findings obtained during a vitrectomy.
  
  
  METHODS
  A 69-year-old male presented with gradual visual impairment due to a milky white tumour that extended from the optic disc into the vitreous cavity. A systemic examination revealed primary squamous cell lung cancer.
  
  
  RESULTS
  A biopsy specimen was obtained from the optic disc tumor during a vitrectomy, which led to a diagnosis of metastasis from lung cancer. Despite courses of chemotherapy and radiotherapy, the patient died of brain metastasis.
  
  
  CONCLUSIONS
  There are few reports of secondary optic disc tumors and pathological biopsy findings are rare. When a milky white tumor is observed extending from the optic disc, a possible differential diagnosis is metastatic neoplasm.
authors.affiliation: Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo Bunkyo-ku, Tokyo, Japan. reina.fukuda@gmail.com
authors.forename: Reina
authors.initials: R
authors.lastname: Fukuda
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Tanabe
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Sawamura
authors.forename: Mikiko
authors.initials: M
authors.lastname: Kawata
authors.forename: Hideki
authors.initials: H
authors.lastname: Tsuji
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Kaburaki
mesh_terms: D000368:Aged; D001706:Biopsy; D001932:Brain Neoplasms / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D017809:Fatal Outcome; D005451:Fluorescein Angiography; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009898:Optic Disk / Q000473:pathology*; D019574:Optic Nerve Neoplasms / Q000556:secondary*; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity; D014821:Vitrectomy