title: [Changes in the red blood cell system and in the activity of free radical processes in rats during chronic nitrite intoxication and alpha-tocopherol administration].
abstract: The red blood cell system and the activity of free radical processes were studied in pregnant rats during chronic nitrite intoxication (oral 0.2% sodium nitrite solution) and during alpha-tocopherol administration (in an intramuscular dose of 150 mg/kg). In intact pregnant rats, alpha-tocopherol decreased the activity of free radical processes and increased the antioxidant potential. Its administration to pregnant rats with nitrite intoxication prevents the elevated concentration of hemoglobin, considerably decreases the activity of free radical processes, and increases the antioxidant activity of serum.
authors.forename: A S
authors.initials: AS
authors.lastname: Ivanova
authors.forename: O G
authors.initials: OG
authors.lastname: Sitnikova
authors.forename: S B
authors.initials: SB
authors.lastname: Nazarov
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002908:Chronic Disease; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D009566:Nitrates / Q000633:toxicity*; D018384:Oxidative Stress; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000139:chemically induced; D011270:Pregnancy, Animal; D051381:Rats; D024502:alpha-Tocopherol / Q000008:administration & dosage*
chemical_list: D002273:Carcinogens; D005609:Free Radicals; D009566:Nitrates; C031618:sodium nitrate; D024502:alpha-Tocopherol