title: Antimicrobial and antioxidant activities of new metal complexes derived from 3-aminocoumarin.
abstract: 3-Aminocoumarin (L) has been synthesized and used as a ligand for the formation of Cr(III), Ni(II), and Cu(II) complexes. The chemical structures were characterized using different spectroscopic methods. The elemental analyses revealed that the complexes where M=Ni(II) and Cu(II) have the general formulae [ML(2)Cl(2)], while the Cr(III) complex has the formula [CrL(2)Cl(2)]Cl. The molar conductance data reveal that all the metal chelates, except the Cr(III) one, are non-electrolytes. From the magnetic and UV-Visible spectra, it is found that these complexes have octahedral structures. The stability for the prepared complexes was studied theoretically using Density Function Theory. The total energy for the complexes was calculated and it was shown that the copper complex is the most stable one. Complexes were tested against selected types of microbial organisms and showed significant activities. The free radical scavenging activity of metal complexes have been determined by measuring their interaction with the stable free radical DPPH and all the compounds have shown encouraging antioxidant activities.
authors.affiliation: Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia.
authors.forename: Abdul Amir H
authors.initials: AA
authors.lastname: Kadhum
authors.forename: Abu Bakar
authors.initials: AB
authors.lastname: Mohamad
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Al-Amiery
authors.forename: Mohd S
authors.initials: MS
authors.lastname: Takriff
mesh_terms: D049933:Aminocoumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors / Q000378:metabolism; D002236:Carbohydrate Conformation; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002857:Chromium / Q000378:metabolism; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology; D003300:Copper / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D009532:Nickel / Q000378:metabolism; D010851:Picrates / Q000037:antagonists & inhibitors / Q000378:metabolism; D013053:Spectrophotometry; D013816:Thermodynamics
chemical_list: D049933:Aminocoumarins; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D002614:Chelating Agents; D056831:Coordination Complexes; D010851:Picrates; D002857:Chromium; D003300:Copper; D009532:Nickel; C004931:1,1-diphenyl-2-picrylhydrazyl