title: Is there a role of the local tissue RAS in the regulation of physiologic and pathophysiologic conditions in the reproductive tract?
abstract: The renin-angiotensin system is well known as a systemic endocrine pathway that regulates blood pressure and salt-water metabolism. In addition to the systemic renin-angiotensin system there is evidence in different species for the presence of a local tissue renin-angiotensin system, which allows local production of the bioactive peptides angiotensin II and angiotensin (1-7). The local renin-angiotensin system has been found in a variety of tissues including tissue of the human reproductive tract. Thus, it was suspected that it may have important functions in the local hormonal microenvironment. Here, a systematic literature search was undertaken to review whether there is evidence for regulatory functions of the local tissue renin-angiotensin system in the human reproductive tract under physiological and pathological conditions.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Ulm, Germany.
authors.forename: Lukas
authors.initials: L
authors.lastname: Schwentner
authors.forename: Achim
authors.initials: A
authors.lastname: Wöckel
authors.forename: Daniel
authors.initials: D
authors.lastname: Herr
authors.forename: Christine
authors.initials: C
authors.lastname: Wulff
mesh_terms: D005835:Genitalia / Q000502:physiology* / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D012084:Renin-Angiotensin System / Q000502:physiology*