title: An experimental outer membrane vesicle vaccine from N. meningitidis serogroup B strains that induces serum bactericidal activity to multiple serogroups.
abstract: A trivalent native outer membrane vesicle vaccine that has potential to provide broad based protection against Neisseria meningitidis serogroup B strains has been developed. Preliminary immunogenicity studies in mice showed that the vaccine was capable of inducing an effective broad based bactericidal antibody response against N. meningitidis serogroup B strains. These findings in mice have been repeated with a cGMP trivalent NOMV vaccine and extended to show that the bactericidal antibody response induced by the vaccine in mice is effective against strains belonging to serogroups C, Y, W135, X, and NadA-expressing serogroup A strains. Taken together these results suggest that this experimental vaccine may provide protection against both serogroup B and non-serogroup B N. meningitidis strains.
authors.affiliation: Division of Bacterial and Rickettsial Diseases, 503 Robert Grant Ave., Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA. valerian.pinto@us.army.mil
authors.forename: Valerian B
authors.initials: VB
authors.lastname: Pinto
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Moran
authors.forename: Francisco
authors.initials: F
authors.lastname: Cruz
authors.forename: Xin-Ming
authors.initials: XM
authors.lastname: Wang
authors.forename: Arthur
authors.initials: A
authors.lastname: Fridman
authors.forename: Wendell D
authors.initials: WD
authors.lastname: Zollinger
authors.forename: Craig T
authors.initials: CT
authors.lastname: Przysiecki
authors.forename: Robert
authors.initials: R
authors.lastname: Burden
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D001770:Blood Bactericidal Activity; D003429:Cross Reactions; D055354:Exosomes / Q000276:immunology*; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D038541:Neisseria meningitidis, Serogroup B / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D022401:Meningococcal Vaccines