title: Synthesis of a MUC1-glycopeptide-BSA conjugate vaccine bearing the 3'-deoxy-3'-fluoro-Thomsen-Friedenreich antigen.
abstract: A novel MUC1-glycopeptide-BSA conjugate vaccine with a specifically fluorinated Thomsen-Friedenreich antigen side chain at Thr6 was prepared. Preliminary immunological experiments reveal specific binding of the tumor-associated glycopeptide antigen analog by anti-MUC1-mouse antibodies.
authors.affiliation: Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Mainz, Germany. hroeder@uni-mainz.de
authors.forename: Anja
authors.initials: A
authors.lastname: Hoffmann-Röder
authors.forename: Manuel
authors.initials: M
authors.lastname: Johannes
mesh_terms: D000818:Animals; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism*; D002417:Cattle; D006020:Glycopeptides / Q000378:metabolism*; D051379:Mice; D018396:Mucin-1 / Q000378:metabolism*; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D018074:Vaccines, Conjugate / Q000737:chemistry / Q000276:immunology / Q000378:metabolism
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D006020:Glycopeptides; D018396:Mucin-1; D018074:Vaccines, Conjugate; D012710:Serum Albumin, Bovine; C016467:Thomsen-Friedenreich antigen