title: The Brain's Aging Immune System.
abstract: In this review, we summarize key observations supporting the idea of immunosenescence in the CNS. We provide a discussion of senescent changes that affect microglial cells and emphasize differences between laboratory rodents and humans. Microglial immunosenescence may explain why humans but not rodents develop neurofibrillary degeneration.
authors.affiliation: Department of Neuroscience, University of Florida College of Medicine and Evelyn F. McKnight Brain Institute, Gainesville, FL, USA.
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Streit
authors.forename: Qing-Shan
authors.initials: QS
authors.lastname: Xue