title: Opioid-induced constipation in advanced illness: safety and efficacy of methylnaltrexone bromide.
abstract: Constipation, one of the major side effects of opiates used in palliative care, can impair patients' quality of life to a point where it prevents sufficient pain control. Methylnaltrexone is a novel μ-receptor antagonist, which does not pass the blood brain barrier. It is licensed to treat opiate induced constipation for patients with advanced diseases. This review article presents an overview of pharmacology and safety of its application, evidence of its efficacy and economic aspects of its use in clinical practice. Available data are limited but strongly suggest that methylnaltrexone causes laxation in less than 24 hours for at least half of those patients over the first two weeks of usage without impairing pain control or causing serious adverse effects. To avoid danger of gastrointestinal perforation it is contraindicated for patients at risk for that complication. More research is needed to evaluate its long-term efficacy and economic impact.
authors.affiliation: Department of Palliative Care, University Hospital Freiburg, Robert-Koch-Str. 3, D-79106, Freiburg.
authors.forename: S
authors.initials: S
authors.lastname: Bader
authors.forename: K
authors.initials: K
authors.lastname: Jaroslawski
authors.forename: H E
authors.initials: HE
authors.lastname: Blum
authors.forename: G
authors.initials: G
authors.lastname: Becker