title: Pulmonary capillaritis leading to alveolar hemorrhage in a juvenile idiopathic arthritis patient: first description.
abstract: Juvenile idiopathic arthritis (JIA) is characterized by the typical joint involvement and some patients have extra-articular lesions, such as uveitis and pleuritis. However, until this date, no case of alveolar hemorrhage in JIA has been described. Herein, the authors describe a case of a male patient, 33 years old diagnosed as polyarticular JIA who had a dramatic evolution with alveolar hemorrhage secondary to pulmonary capillaritis. He received intravenous immunoglobulin and pulse therapies with glucocorticoid and cyclophosphamide with a satisfactory outcome. In addition, the authors review this important pulmonary complication in rheumatic diseases.
authors.forename: Elisa
authors.initials: E
authors.lastname: Watanabe
authors.forename: Leonardo Rios
authors.initials: LR
authors.lastname: Diniz
authors.forename: Licia Maria Henrique
authors.initials: LM
authors.lastname: da Mota
authors.forename: Solange Murta
authors.initials: SM
authors.lastname: Barros
authors.forename: Jozélio Freire
authors.initials: JF
authors.lastname: de Carvalho
mesh_terms: D000328:Adult; D001171:Arthritis, Juvenile / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D001706:Biopsy; D002196:Capillaries / Q000473:pathology*; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008168:Lung / Q000098:blood supply*; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D020551:Pulse Therapy, Drug; D012121:Respiration, Artificial; D014139:Tracheostomy; D016896:Treatment Outcome; D014657:Vasculitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide