title: Selective killing of bacterial persisters by a single chemical compound without affecting normal antibiotic-sensitive cells.
abstract: We show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensitive cells. C10 led persisters to antibiotic-induced cell death by causing reversion of persisters to antibiotic-sensitive cells. This work is the first demonstration in which the eradication of bacterial persisters is based on single-chemical supplementation. The chemical should be versatile in elucidating the mechanism of persistence.
authors.affiliation: School of Life Science and Biotechnology, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, South Korea.
authors.forename: Jun-Seob
authors.initials: JS
authors.lastname: Kim
authors.forename: Paul
authors.initials: P
authors.lastname: Heo
authors.forename: Tae-Jun
authors.initials: TJ
authors.lastname: Yang
authors.forename: Ki-Sing
authors.initials: KS
authors.lastname: Lee
authors.forename: Da-Hyeong
authors.initials: DH
authors.lastname: Cho
authors.forename: Bum Tae
authors.initials: BT
authors.lastname: Kim
authors.forename: Ji-Hee
authors.initials: JH
authors.lastname: Suh
authors.forename: Hee-Jong
authors.initials: HJ
authors.lastname: Lim
authors.forename: Dongwoo
authors.initials: D
authors.lastname: Shin
authors.forename: Sung-Koo
authors.initials: SK
authors.lastname: Kim
authors.forename: Dae-Hyuk
authors.initials: DH
authors.lastname: Kweon
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents