title: Monte Carlo estimation of dose difference in lung from 192Ir brachytherapy due to tissue inhomogeneity.
abstract: Lung brachytherapy using high-dose rate (192)Ir technique is a well-established technique of radiation therapy. However, many commercial treatment planning systems do not have the ability to consider the inhomogeneity of lung in relation to normal tissue. Under such circumstances dose calculations for tissues and organs at risk close to the target are inaccurate. The purpose of the current study was to estimate the dose difference due to tissue inhomogeneity using the Monte Carlo simulation code MCNP-5. Results showed that there was a relative sub dosage by treatment planning systems calculations in neighbouring tissues around the radioactive source due to inhomogeneity ignorance. The presence of lung instead of normal tissue resulted in an increase in relative dose, which approached 8 % at 4-cm distance from the source. Additionally, the relative increase was small for the lung (2.1 %) and larger for organs at risk such as the heart (6.8 %) and bone marrow (7.6 %).
authors.affiliation: Medical Physics Department, IASSO Hospital, 37-39 Kifissias Str, Maroussi 15123, Athens, Greece. gialousis@med.uoa.gr
authors.forename: G
authors.initials: G
authors.lastname: Gialousis
authors.forename: A
authors.initials: A
authors.lastname: Dimitriadis
authors.forename: E
authors.initials: E
authors.lastname: Yakoumakis
mesh_terms: D000465:Algorithms; D001853:Bone Marrow / Q000528:radiation effects; D001918:Brachytherapy; D003198:Computer Simulation; D006321:Heart / Q000528:radiation effects; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000532:radiotherapy*; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D011874:Radiometry; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012062:Relative Biological Effectiveness
chemical_list: D007496:Iridium Radioisotopes