title: Assessing behavioural manifestations prior to clinical diagnosis of huntington disease: "anger and irritability" and "obsessions and compulsions".
abstract: The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess "Anger and Irritability" and "Obsessions and Compulsions" in prHD individuals.
authors.affiliation: Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Vaccarino
authors.lastname: Anonymous
authors.forename: Karen E
authors.initials: KE
authors.lastname: Anderson
authors.forename: Beth
authors.initials: B
authors.lastname: Borowsky
authors.forename: Emil
authors.initials: E
authors.lastname: Coccaro
authors.forename: David
authors.initials: D
authors.lastname: Craufurd
authors.forename: Jean
authors.initials: J
authors.lastname: Endicott
authors.forename: Joseph
authors.initials: J
authors.lastname: Giuliano
authors.forename: Mark
authors.initials: M
authors.lastname: Groves
authors.forename: Mark
authors.initials: M
authors.lastname: Guttman
authors.forename: Aileen K
authors.initials: AK
authors.lastname: Ho
authors.forename: Peter
authors.initials: P
authors.lastname: Kupchak
authors.forename: Jane S
authors.initials: JS
authors.lastname: Paulsen
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Stanford
authors.forename: Daniel P
authors.initials: DP
authors.lastname: van Kammen
authors.forename: David
authors.initials: D
authors.lastname: Watson
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Wu
authors.forename: Ken
authors.initials: K
authors.lastname: Evans