title: Kinetic resolution of N-acyl-β-lactams via benzotetramisole-catalyzed enantioselective alcoholysis.
abstract: The first nonenzymatic kinetic resolution of β-lactams has been achieved. Alcoholysis of their N-aroyl derivatives in the presence of a simple chiral acyl transfer catalyst, benzotetramisole, produces β-amino acid derivatives with excellent enantioselectivity.
authors.affiliation: Department of Chemistry, Washington University, St. Louis, Missouri 63130, United States.
authors.forename: Valentina D
authors.initials: VD
authors.lastname: Bumbu
authors.forename: Vladimir B
authors.initials: VB
authors.lastname: Birman
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D007700:Kinetics; D013237:Stereoisomerism; D013773:Tetramisole / Q000031:analogs & derivatives* / Q000737:chemistry; D047090:beta-Lactams / Q000737:chemistry*
chemical_list: D000596:Amino Acids; C515434:benzotetramisole; D047090:beta-Lactams; D013773:Tetramisole