title: [High-grade prostatic intraepithelial neoplasia: the only accepted prostate cancer precursor lesion].
abstract: For many tumors the early detection of precursor lesions of invasive cancer has an impact on the clinical course. The high-grade prostatic intraepithelial neoplasia (HG-PIN) is the only accepted facultative precursor lesion for acinar prostate cancer. While HG-PIN shows many similarities to prostate cancer it is most probably not a precursor of every prostate cancer variant. However, the detection of HG-PIN in needle biopsies is a significant risk factor for the subsequent diagnosis of invasive prostate cancer. Low-grade PIN (LG-PIN), proliferative inflammatory atrophy (PIA), and atypical adenomatous hyperplasia are no longer considered to be true precursor lesions.
authors.affiliation: Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Braun
authors.forename: S
authors.initials: S
authors.lastname: Perner
mesh_terms: D001707:Biopsy, Needle; D002278:Carcinoma in Situ / Q000235:genetics* / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology*; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000235:genetics / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology*