title: Anti-inflammatory therapies in cancer cachexia.
abstract: Disease progression in cancer is dependent on the complex interaction between the tumor and the host inflammatory response. Indeed, both the tumor and the patient produce cytokines that act on multiple target sites such as bone marrow, myocytes, hepatocytes, adipocytes, endothelial cells and neurons, where they produce a complex cascade of biological responses leading to the wasting associated with cachexia. The cytokines that have been involved in this cachectic response are TNF-alpha, IL-1, IL-6 and interferon-gamma. Interestingly, these cytokines share the same metabolic effects and their activities are closely interrelated. In many cases these cytokines exhibit synergic effects when administered together. Therefore, therapeutic strategies - either nutritional or pharmacological - have been based on either blocking their synthesis or their action.
authors.affiliation: Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain. jargiles@ub.edu
authors.forename: Josep M
authors.initials: JM
authors.lastname: Argilés
authors.forename: Sílvia
authors.initials: S
authors.lastname: Busquets
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: López-Soriano
mesh_terms: D000818:Animals; D002100:Cachexia / Q000150:complications / Q000178:diet therapy* / Q000188:drug therapy* / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000150:complications*; D019282:Wasting Syndrome / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy / Q000378:metabolism
chemical_list: D016207:Cytokines