title: An electronic analog of synthetic genetic networks.
abstract: An electronic analog of a synthetic genetic network known as the repressilator is proposed. The repressilator is a synthetic biological clock consisting of a cyclic inhibitory network of three negative regulatory genes which produces oscillations in the expressed protein concentrations. Compared to previous circuit analogs of the repressilator, the circuit here takes into account more accurately the kinetics of gene expression, inhibition, and protein degradation. A good agreement between circuit measurements and numerical prediction is observed. The circuit allows for easy control of the kinetic parameters thereby aiding investigations of large varieties of potential dynamics.
authors.affiliation: Department of Physics and Astronomy, University of North Carolina Greensboro, Greensboro, North Carolina, United States of America. ehhellen@uncg.edu
authors.forename: Edward H
authors.initials: EH
authors.lastname: Hellen
authors.forename: Evgenii
authors.initials: E
authors.lastname: Volkov
authors.forename: Jurgen
authors.initials: J
authors.lastname: Kurths
authors.forename: Syamal Kumar
authors.initials: SK
authors.lastname: Dana
mesh_terms: D015870:Gene Expression; D053263:Gene Regulatory Networks; D008962:Models, Theoretical