title: Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier.
abstract: A library of 32 organoruthenium compounds has been synthesised. Known and novel C-N cyclometalated compounds as well as N-C-N and N-N-C pincer derivatives of this metal have been used in this purpose. Most of the compounds have been tested for their in vitro antitumoral behaviours, good to excellent activities have thus been found. Several of the newly synthesized compounds pass the symbolic barrier of the nanomolar range for their IC(50) indicating a critical improvement. The level of activity is tentatively correlated to physicochemical properties of the compounds such as their Ru(III/II) redox potential and their lipophilicity (log P).
authors.affiliation: Institut de Chimie, UMR 7177, CNRS, Université de Strasbourg, 4, rue Blaise Pascal, 67000, Strasbourg, France.
authors.forename: Ludivine
authors.initials: L
authors.lastname: Fetzer
authors.forename: Bastien
authors.initials: B
authors.lastname: Boff
authors.forename: Moussa
authors.initials: M
authors.lastname: Ali
authors.forename: Meng
authors.initials: M
authors.lastname: Xiangjun
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Collin
authors.forename: Claude
authors.initials: C
authors.lastname: Sirlin
authors.forename: Christian
authors.initials: C
authors.lastname: Gaiddon
authors.forename: Michel
authors.initials: M
authors.lastname: Pfeffer
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012428:Ruthenium