title: Impact of differential glycosylation on IgG activity.
abstract: Immunoglobulin G (IgG) molecules are glycoproteins with dual functionality. While participating in the destruction of virally infected cells or healthy tissues during autoimmune disease, IgG antibodies are also used as a therapeutic agent to suppress IgG-triggered autoimmune disease and inflammation. Research of recent years has put the IgG-associated sugar moiety in the spotlight for regulating these opposing activities. This review will focus on how certain IgG glycovariants impact different IgG-dependent effector functions and how this knowledge might be used to further improve the therapeutic effectiveness of this class of molecules.
authors.forename: Anja
authors.initials: A
authors.lastname: Lux
authors.forename: Falk
authors.initials: F
authors.lastname: Nimmerjahn
mesh_terms: D000117:Acetylglucosamine / Q000737:chemistry / Q000276:immunology; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D002240:Carbohydrate Sequence; D005643:Fucose / Q000737:chemistry / Q000276:immunology; D005690:Galactose / Q000737:chemistry / Q000276:immunology; D006031:Glycosylation; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology* / Q000627:therapeutic use; D007074:Immunoglobulin G / Q000276:immunology / Q000627:therapeutic use; D007132:Immunoglobulin Isotypes / Q000737:chemistry / Q000276:immunology*; D007249:Inflammation / Q000276:immunology / Q000628:therapy; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D017452:Receptors, IgG / Q000276:immunology*; D012794:Sialic Acids / Q000737:chemistry / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000628:therapy / Q000821:virology
chemical_list: D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D017452:Receptors, IgG; D012794:Sialic Acids; D005643:Fucose; D000117:Acetylglucosamine; D005690:Galactose