title: Drug monitoring of a case of citalopram overdosage.
abstract: Selective serotonin reuptake inhibitors are widely prescribed drugs without recognized cardiovascular risk. We report the case of a 54-year-old patient who developed QTc interval prolongation, followed by ventricular fibrillation episodes, 10 hours after admission to the ICU, in the setting of a citalopram overdose. Citalopram plasma values dropped from 5.88 to 0.34 mg/L at 9 days postadmission. The patient was treated by oral activated charcoal, and final outcome was favorable.
authors.affiliation: CHU Clermont-Ferrand, Hospital G. Montpied, Nephrology and Intensive Care Unit, Clermont- Ferrand, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Liotier
authors.forename: François
authors.initials: F
authors.lastname: Coudoré
mesh_terms: D015283:Citalopram / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood* / Q000627:therapeutic use; D016903:Drug Monitoring; D062787:Drug Overdose; D004562:Electrocardiography; D005260:Female; D006207:Half-Life; D006801:Humans; D008133:Long QT Syndrome / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood* / Q000627:therapeutic use; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors