title: Progression of pancreatitis prior to diabetes onset in WBN/Kob-Lepr(fa) rats.
abstract: We established the WBN/Kob-Lepr(fa) rat as a new congenic strain for the fa allele of the leptin receptor gene (Lepr). Homozygous (fa/fa) WBN/Kob-Lepr(fa) rats provide a model of non-insulin-dependent diabetes, although its onset is secondary to pancreatitis. In the present study, we compared histopathological observations of pancreatitis in each genotype of this rat, to examine its suitability as a model of pancreatitis. The histopathological findings of the pancreatitis revealed intense changes dependent on age, such as hemorrhage or hemosiderin deposition. The pancreatitis in homozygous (fa/fa) WBN/Kob-Lepr(fa) rats were more severe than those of WBN/Kob rats.
authors.affiliation: Division of Laboratory Animal Science, Nippon Medical School, Tokyo, Japan. toshio@nms.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Akimoto
authors.forename: Misao
authors.initials: M
authors.lastname: Terada
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
mesh_terms: D000375:Aging; D000818:Animals; D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D009765:Obesity; D010195:Pancreatitis / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose