title: Signal transduction by mitochondrial oxidants.
abstract: The production of mitochondrial reactive oxygen species occurs as a consequence of aerobic metabolism. Mitochondrial oxidants are increasingly viewed less as byproducts of metabolism and more as important signaling molecules. Here, I review several notable examples, including the cellular response to hypoxia, aspects of innate immunity, the regulation of autophagy, and stem cell self-renewal capacity, where evidence suggests an important regulatory role for mitochondrial oxidants.
authors.affiliation: Center for Molecular Medicine, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. finkelt@nih.gov
authors.forename: Toren
authors.initials: T
authors.lastname: Finkel
mesh_terms: D000818:Animals; D006801:Humans; D000860:Hypoxia / Q000276:immunology / Q000378:metabolism; D007113:Immunity, Innate / Q000502:physiology*; D008928:Mitochondria / Q000276:immunology / Q000378:metabolism; D016877:Oxidants / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013234:Stem Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D016877:Oxidants