title: RNAi pathway integration in Caenorhabditis elegans development.
abstract: In this review, the pathways involving small RNAs are provided followed by a new and updated network that illustrates their interplay with diverse cellular mechanisms in Caenorhabditis elegans. The RNA silencing pathways are now recognized as key factors that connect together the many variations in biological processes, including transcriptional gene regulation, post-transcriptional gene silencing, translational gene silencing, apoptosis, meiosis, and antiviral defense. The utilization of small RNAs represents a specific, energy conserving, and fast mechanism of gene regulation via a core system known as RNA interference.
authors.affiliation: Laboratory of Systems Biology and Bioinformatics, Institute of Biochemistry and Biophysics and COE in Biomathematics, University of Tehran, Iran.
authors.forename: Sadegh
authors.initials: S
authors.lastname: Azimzadeh Jamalkandi
authors.forename: Ali
authors.initials: A
authors.lastname: Masoudi-Nejad
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000254:growth & development* / Q000821:virology; D002843:Chromatin / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D055785:Gene Knockdown Techniques; D053263:Gene Regulatory Networks; D007113:Immunity, Innate; D008540:Meiosis / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D014780:Viruses / Q000235:genetics
chemical_list: D002843:Chromatin; D035683:MicroRNAs; D034741:RNA, Small Interfering