title: Intratumoural level of SDF-1 correlates with survival in head and neck squamous cell carcinoma.
abstract: The SDF-1/CXCR4 pathway has been suggested to play a role in the metastatic dissemination of various tumours. We assessed the prognostic impact of SDF-1 and CXCR4 expression in head and neck squamous cell carcinoma (HNSCC). Seventy-one HNSCC samples collected at the time of initial diagnosis were retrospectively analysed. SDF-1 and CXCR4 expression levels were measured using real-time RT-PCR and correlated to survival. After a median follow-up of 45 months, 25 patients (35%) died of cancer (group D), and 46 patients (65%) were alive or dead without evidence of HSNCC evolution (group A). The median level of CXCR4 expression was 0.33 and 0.29 in groups A and D, respectively (P=0.93), showing no correlation with recurrence or survival. By contrast, the median level of SDF-1 expression was significantly different in the A and D groups (2.41 vs 1.16, respectively, P=0.018). Using the median level as a cut-off, patients with low SDF-1 had poorer metastasis-free (P=0.026), disease-free (P=0.006) and overall specific survival rates (P=0.002). The prognostic value of SDF-1 was confirmed by a multivariate analysis. In this series of 71 HNSCC patients, the SDF-1 expression level correlated significantly with metastatic evolution and overall survival.
authors.affiliation: Department of Medical Oncology, Centre Henri Becquerel, 1 rue d'Amiens, 76038 Rouen cedex, France. fclatot@yahoo.fr
authors.forename: Florian
authors.initials: F
authors.lastname: Clatot
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Picquenot
authors.forename: Olivier
authors.initials: O
authors.lastname: Choussy
authors.forename: Sophie
authors.initials: S
authors.lastname: Gouérant
authors.forename: Cristian
authors.initials: C
authors.lastname: Moldovan
authors.forename: Didier
authors.initials: D
authors.lastname: Schultheis
authors.forename: Marie
authors.initials: M
authors.lastname: Cornic
authors.forename: Arnaud
authors.initials: A
authors.lastname: François
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Blot
authors.forename: Sophie
authors.initials: S
authors.lastname: Laberge-Le-Couteulx
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D054377:Chemokine CXCL12 / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000401:mortality*; D011379:Prognosis; D019718:Receptors, CXCR4 / Q000378:metabolism*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D054377:Chemokine CXCL12; D019718:Receptors, CXCR4