title: Metformin-associated lactic acidosis in a patient with normal kidney function.
abstract: The existence of metformin-induced lactic acidosis has been questioned, in particular in the absence of specific risk factors such as impaired renal function. This report describes the presence of lactic acidosis in a patient with normal kidney function and normal doses of metformin. Subsequent positive rechallenge with metformin confirms causality.
authors.affiliation: Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: T T
authors.initials: TT
authors.lastname: van Sloten
authors.forename: E
authors.initials: E
authors.lastname: Pijpers
authors.forename: C D A
authors.initials: CD
authors.lastname: Stehouwer
authors.forename: M C G J
authors.initials: MC
authors.lastname: Brouwers
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000503:physiopathology; D000369:Aged, 80 and over; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin