title: Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera.
abstract: After decades of Alzheimer's disease (AD) research, the development of a definitive diagnostic test for this disease has remained elusive. The discovery of blood-borne biomarkers yielding an accurate and relatively non-invasive test has been a primary goal. Using human protein microarrays to characterize the differential expression of serum autoantibodies in AD and non-demented control (NDC) groups, we identified potential diagnostic biomarkers for AD. The differential significance of each biomarker was evaluated, resulting in the selection of only 10 autoantibody biomarkers that can effectively differentiate AD sera from NDC sera with a sensitivity of 96.0% and specificity of 92.5%. AD sera were also distinguishable from sera obtained from patients with Parkinson's disease and breast cancer with accuracies of 86% and 92%, respectively. Results demonstrate that serum autoantibodies can be used effectively as highly-specific and accurate biomarkers to diagnose AD throughout the course of the disease.
authors.affiliation: Durin Technologies, Inc., New Brunswick, New Jersey, United States of America. nagelero@umdnj.edu
authors.forename: Eric
authors.initials: E
authors.lastname: Nagele
authors.forename: Min
authors.initials: M
authors.lastname: Han
authors.forename: Cassandra
authors.initials: C
authors.lastname: Demarshall
authors.forename: Benjamin
authors.initials: B
authors.lastname: Belinka
authors.forename: Robert
authors.initials: R
authors.lastname: Nagele
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D040081:Protein Array Analysis; D055815:Young Adult
chemical_list: D001323:Autoantibodies