title: Phenylethyl cinnamides as potential alpha-glucosidase inhibitors from the roots of Solanum melongena.
abstract: Bioassay-guided fractionation against alpha-glucosidase resulted in isolation and identification of six phenolic compounds (1-6) from the 70% EtOH extract of the roots of Solanum melongena L. (Solanaceae). Of these, three phenylethyl cinnamides, N-trans-feruloyl tyramine (1), N-trans-p-coumaroyl tyramine (2) and N-cis-p-coumaroyl tyramine (3) possessed inhibitory activity against alpha-glucosidase with IC50 values of 500.6, 5.3 and 46.3 microM, respectively. Mechanism analysis revealed these phenylethyl cinnamides were non-competitive inhibitors. This is the first study of the alpha-glucosidase inhibitory activities of the roots of S. melongena, and this preliminary observation suggested potential medicinal use of this herb.
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, People's Republic of China.
authors.forename: Xuchun
authors.initials: X
authors.lastname: Liu
authors.forename: Jianguang
authors.initials: J
authors.lastname: Luo
authors.forename: Lingyi
authors.initials: L
authors.lastname: Kong
mesh_terms: D002934:Cinnamates / Q000737:chemistry* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D032323:Solanum melongena / Q000737:chemistry*
chemical_list: D002934:Cinnamates; D065089:Glycoside Hydrolase Inhibitors; C029010:cinnamic acid