title: The reaction of methionine with hydroxyl radical: reactive intermediates and methanethiol production.
abstract: The mechanisms of reaction of methionine with hydroxyl radical are not fully understood. Here, we unequivocally show using electron paramagnetic resonance spin-trapping spectroscopy and GC-FID and GC-MS, the presence of specific carbon-, nitrogen- and sulfur-centered radicals as intermediates of this reaction, as well as the liberation of methanethiol as a gaseous end product. Taking into account the many roles that methionine has in eco- and biosystems, our results may elucidate redox chemistry of this amino acid and processes that methionine is involved in.
authors.affiliation: Institute for Multidisciplinary Research, University of Belgrade, Kneza Višeslava 1, 11000, Belgrade, Serbia. redoxsci@gmail.com
authors.forename: Ivan
authors.initials: I
authors.lastname: Spasojević
authors.forename: Jelena
authors.initials: J
authors.lastname: Bogdanović Pristov
authors.forename: Ljubodrag
authors.initials: L
authors.lastname: Vujisić
authors.forename: Mihajlo
authors.initials: M
authors.lastname: Spasić
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D008401:Gas Chromatography-Mass Spectrometry; D005740:Gases; D017665:Hydroxyl Radical / Q000737:chemistry*; D008715:Methionine / Q000737:chemistry*; D010084:Oxidation-Reduction; D019097:Spin Trapping; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D005740:Gases; D013438:Sulfhydryl Compounds; C005231:methylmercaptan; D017665:Hydroxyl Radical; D008715:Methionine