title: Changes in magnetic resonance imaging signal intensity of transplanted meniscus allografts are not associated with clinical outcomes.
abstract: OBJECTIVE
  To evaluate changes in intrameniscal signal intensity (IMSI) of transplanted allografts during the first year after meniscus allograft transplantation (MAT) by use of serial magnetic resonance imaging, as well as to analyze the relation between IMSI and clinical outcome.
  
  
  METHODS
  This prospective study involved 43 patients who underwent MAT between 2006 and 2007 after diagnosis of total or subtotal meniscectomized knees. The mean patient age at the time of surgery was 35.8 years (range, 17 to 46 years). Allografts were assessed by conventional magnetic resonance imaging performed at 6 weeks and 3, 6, and 12 months after MAT. The ratio of the signal intensity of the transplanted meniscus allograft to that of the control normal meniscus in the ipsilateral knee was calculated to obtain a standardized signal intensity value. IMSI was assessed in terms of postoperative time and location (anterior v posterior horn). The Lysholm score was used to evaluate knee function.
  
  
  RESULTS
  The IMSI of transplanted allograft menisci was higher than that for nontransplanted menisci at all 4 postoperative time points (P < .01). The anterior horn allograft IMSI was greater than the posterior horn allograft IMSI at all time points (P < .01). The allograft IMSI increased starting 3 months postoperatively for the anterior horn (F(3,40) = 7.5, P < .01) and 6 months postoperatively for the posterior horn (F(3,40) = 9.2, P < .01). These increases were maintained to the final assessment at 1 year postoperatively. No correlation was found between IMSI and postoperative Lysholm score.
  
  
  CONCLUSIONS
  Transplanted allograft menisci had higher signal intensities than normal menisci. Signal intensity was higher for the anterior horn than the posterior horn throughout the first postoperative year. Signal intensity increased over time, and this increase was maintained at 1 year postoperatively. However, signal intensity was not related to clinical outcome.
  
  
  METHODS
  Level II, development of diagnostic criteria based on analysis of consecutive patients, applying a universally recognized gold standard.
authors.affiliation: Department of Orthopaedic Surgery, College of Medicine, Korea University, Anam Hospital, Seoul, South Korea.
authors.forename: Dae-Hee
authors.initials: DH
authors.lastname: Lee
authors.forename: Bum-Sik
authors.initials: BS
authors.lastname: Lee
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Chung
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Kyung-Sook
authors.initials: KS
authors.lastname: Yang
authors.forename: Eun-Jong
authors.initials: EJ
authors.lastname: Cha
authors.forename: Seong-Il
authors.initials: SI
authors.lastname: Bin
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007718:Knee Injuries / Q000534:rehabilitation; D008279:Magnetic Resonance Imaging; D008297:Male; D008592:Menisci, Tibial / Q000601:surgery* / Q000637:transplantation*; D008875:Middle Aged; D015915:Motion Therapy, Continuous Passive; D026741:Physical Therapy Modalities; D011446:Prospective Studies; D016059:Range of Motion, Articular; D020127:Recovery of Function; D000070600:Tibial Meniscus Injuries; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult