title: Synthesis, crystal structures, photophysical properties, and bioimaging of living cells of bis-β-diketonate phenothiazine ligands and its cyclic dinuclear complexes.
abstract: Two bis-β-diketones, RCOCH(2)CO-EPTZ-COCH(2)COR (EPTZ = 10-ethylphenothiazine; R = C(6)H(5) for H(2)L(1) and CF(3) for H(2)L(2)) and their cyclic dinuclear Zn(II), Cd(II), Ni(II), Mn(II), Cu(II), Co(II) complexes have been synthesized and fully characterized. Their crystal structures were determined by single crystal X-ray diffraction analysis. Their photophysical properties have been further investigated both experimentally and theoretically. The results revealed that significant enhancement of two-photon absorption cross section values were obtained for the cyclic dinuclear Zn(II) and Cd(II) complexes compared with their free ligands. Additionally, confocal microscopy and two-photon microscopy fluorescent imaging of MCF-7 cells labeled with two ligands and Zn(II) complexes reveal their potential applications as a biological fluorescent probe.
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Materials of Chemistry of Anhui Province, Anhui University, Hefei 230039, P.R. China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Li
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Tian
authors.forename: Guiju
authors.initials: G
authors.lastname: Hu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Pingping
authors.initials: P
authors.lastname: Sun
authors.forename: Hongping
authors.initials: H
authors.lastname: Zhou
authors.forename: Xiangming
authors.initials: X
authors.lastname: Meng
authors.forename: Jiaxiang
authors.initials: J
authors.lastname: Yang
authors.forename: Jieying
authors.initials: J
authors.lastname: Wu
authors.forename: Baokang
authors.initials: B
authors.lastname: Jin
authors.forename: Shengyi
authors.initials: S
authors.lastname: Zhang
authors.forename: Xutang
authors.initials: X
authors.lastname: Tao
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010640:Phenothiazines / Q000737:chemistry*; D055668:Photochemical Processes; D011789:Quantum Theory; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D007659:Ketones; D008024:Ligands; D019216:Metals, Heavy; D009942:Organometallic Compounds; D010640:Phenothiazines