title: Hypercholesterolemia: chemical aspect of approach.
abstract: This review is the first attempt at systematization and analysis of the literature data (covering the last decade) on the chemical structures and specific activities of cholesterol-regulating agents. Six of thirty currently known biological targets for treating hyperlipidemia were selected and considered. All of the chemical structures under study are divided into two classes with different mechanisms of their activity: cholesterol biosynthesis blockers (HMG-CoA reductase and squalene 2,3-oxide-lanosterol cyclase inhibitors) and regulators of cholesterol transformations in the organism (PPARα and PPARα/γ agonists, inhibitors of intestinal absorption of cholesterol, cholesteryl ester transfer protein (CETP) inhibitors, and regulators of low-density-lipoprotein receptor (LDLR) expression).
authors.affiliation: Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9 Novosibirsk, 630090, Russian Federation.
authors.forename: N F
authors.initials: NF
authors.lastname: Salakhutdinov
authors.forename: L N
authors.initials: LN
authors.lastname: Rogoza
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
mesh_terms: D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists* / Q000737:chemistry
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D047492:Peroxisome Proliferator-Activated Receptors; D002784:Cholesterol