title: Recent advances in the therapy of castration-resistant prostate cancer: the price of progress.
abstract: Within the past two years, three agents have garnered approval from the US FDA for the specific treatment of metastatic castration resistant prostate cancer (mCRPC) - (1) abiraterone, (2) cabazitaxel and (3) sipuleucel-T. In separate phase III studies, each agent led to an improvement in overall survival (OS) of 2-4 months over a suitable comparator. With these costly therapies all having potential application in the patient with mCRPC, multiple entities (industry, government, and the general public) must strategize to determine how the cost burden of these agents can be balanced with the potential gains for the individual patient. Herein, we provide a framework with which to approach this dilemma.
authors.affiliation: Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, United States. dhwanishiva@gmail.com
authors.forename: Dhwanishiva
authors.initials: D
authors.lastname: Vasani
authors.forename: David Y
authors.initials: DY
authors.lastname: Josephson
authors.forename: Courtney
authors.initials: C
authors.lastname: Carmichael
authors.forename: Oliver
authors.initials: O
authors.lastname: Sartor
authors.forename: Sumanta Kumar
authors.initials: SK
authors.lastname: Pal
mesh_terms: D000736:Androstenes; D000737:Androstenols / Q000191:economics* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000191:economics* / Q000627:therapeutic use; D017326:Clinical Trials, Phase III as Topic; D016527:Drug Costs; D006801:Humans; D008297:Male; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000191:economics / Q000401:mortality; D043823:Taxoids / Q000191:economics* / Q000627:therapeutic use; D014020:Tissue Extracts / Q000191:economics* / Q000627:therapeutic use
chemical_list: D000736:Androstenes; D000737:Androstenols; D000970:Antineoplastic Agents; D043823:Taxoids; D014020:Tissue Extracts; C552428:cabazitaxel; C511774:sipuleucel-T; C089740:abiraterone