title: The neurovascular link in health and disease: molecular mechanisms and therapeutic implications.
abstract: At first sight, the nervous and vascular systems seem to share little in common. However, neural and vascular cells not only are anatomically closely tied to each other, but they also utilize and respond to similar classes of signals to establish correct connectivity and wiring of their networks. Recent studies further provide evidence that this neurovascular crosstalk is more important for understanding the molecular basis of neurological disease than originally anticipated. Moreover, neurovascular strategies offer novel therapeutic opportunities for neurodegenerative disorders.
authors.affiliation: The laboratory of Angiogenesis & Neurovascular link; Vesalius Research Center, K.U.Leuven, Leuven, B-3000, Belgium.
authors.forename: Annelies
authors.initials: A
authors.lastname: Quaegebeur
authors.forename: Christian
authors.initials: C
authors.lastname: Lange
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D043924:Angiogenesis Modulating Agents / Q000627:therapeutic use; D000818:Animals; D001253:Astrocytes / Q000502:physiology; D001808:Blood Vessels / Q000254:growth & development / Q000502:physiology* / Q000503:physiopathology; D001812:Blood-Brain Barrier / Q000254:growth & development / Q000502:physiology* / Q000503:physiopathology; D001921:Brain / Q000098:blood supply* / Q000254:growth & development / Q000502:physiology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D009420:Nervous System / Q000098:blood supply*; D009422:Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology*; D020286:Pericytes / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology
chemical_list: D043924:Angiogenesis Modulating Agents