title: Mechanical properties and in vivo performance of a novel sliding-lock bioabsorbable poly-p-dioxanone stent.
abstract: A bioabsorbable poly-p-dioxanone (PPDO) stent with a novel sliding-lock structure was fabricated to treat stenotic peripheral vessels. The sliding-lock PPDO stents have greater radial strength (107 kPa) than PPDO stents with conventional net-tube structure (32 kPa). The sliding-lock PPDO stents were implanted into the iliac arteries of pigs, and implantation success rate was 90% indicating the feasibility of this design. Additionally, we found that sliding-lock PPDO stents kept vessels patent, although by 3 and 6 months post implantation, luminal diameter decreased slightly due to intimal hyperplasia. At 1 month post implantation, the stents were sparsely covered with endothelial cells, and by 6 months, the stents were mostly absorbed and inflammatory reaction gradually decreased as the stents were absorbed. This study shows favorable mechanical strength, degradability and efficacy for the sliding-lock PPDO stents, and supports further research and development of this unique design of polymer stents for applications in vascular devices.
authors.affiliation: Children's Heart Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China.
authors.forename: Qimao
authors.initials: Q
authors.lastname: Feng
authors.forename: Wenbo
authors.initials: W
authors.lastname: Jiang
authors.forename: Kun
authors.initials: K
authors.lastname: Sun
authors.forename: Kang
authors.initials: K
authors.lastname: Sun
authors.forename: Sun
authors.initials: S
authors.lastname: Chen
authors.forename: Lijiao
authors.initials: L
authors.lastname: Zhao
authors.forename: Ke
authors.initials: K
authors.lastname: Dai
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
mesh_terms: D020341:Absorbable Implants; D000042:Absorption; D000818:Animals; D001158:Arteries; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D004146:Dioxanes; D011108:Polymers; D015607:Stents; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D004146:Dioxanes; D011108:Polymers; C079733:poly-4-dioxan-2-one