title: Posttransplantation anemia: relationship with inflammatory markers, oxidation, and prohepcidin levels.
abstract: BACKGROUND
  Anemia frequently occurs after kidney transplantation, its origin is multifactorial. The objective of this study was to evaluate the frequency of anemia among kidney transplantation patients at 3 months after transplantation and its relationship to inflammatory, oxidative, and nutritional states. Furthermore, we determined serum prohepcidin, a precursor of hepcidin, the main hormone implicated in iron metabolism.
  
  
  METHODS
  We performed a transverse retrospective study in 130 patients who underwent kidney transplantation, including 89 men and 41 women. Patients were randomized according to the presence or absence of anemia at 3 months. The patients' inflammatory, oxidative, and nutritional states were evaluated as well as renal function and serum prohepcidin at 3 months.
  
  
  RESULTS
  Twenty-four percent of the patients developed anemia at 3 months after transplantation. These patients presented with a greater inflammatory state, a poor nutritional status, and poor renal function. Serum prohepcidin was significantly lower compared with the transplantation patients who did not show anemia.
  
  
  CONCLUSIONS
  Serum prohepcidin was significantly higher among kidney transplantation patients who did not develop anemia. The inflammatory state may be a determinant of the response to treatment with erythropoiesis-stimulating agents in anemic kidney transplant recipients.
authors.affiliation: Department of Biochemistry, Hospital Universitari Germans Trias I Pujol, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Sancho
authors.forename: M C
authors.initials: MC
authors.lastname: Pastor
authors.forename: L
authors.initials: L
authors.lastname: Cañas
authors.forename: C
authors.initials: C
authors.lastname: Morales Indiano
authors.forename: M
authors.initials: M
authors.lastname: Ardèvol
authors.forename: S
authors.initials: S
authors.lastname: Aguerrevere
authors.forename: J
authors.initials: J
authors.lastname: Juega
authors.forename: R
authors.initials: R
authors.lastname: Romero
authors.forename: R
authors.initials: R
authors.lastname: Lauzurica
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006397:Hematinics / Q000627:therapeutic use; D064451:Hepcidins; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology* / Q000276:immunology; D018836:Inflammation Mediators / Q000097:blood*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D018384:Oxidative Stress; D011498:Protein Precursors / Q000097:blood*; D012189:Retrospective Studies; D013030:Spain; D013997:Time Factors
chemical_list: D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; D006397:Hematinics; D064451:Hepcidins; D018836:Inflammation Mediators; D011498:Protein Precursors