title: Cytotoxic copper (II) mixed ligand complexes: crystal structure and DNA cleavage activity.
abstract: Two new mixed ligand complexes of copper (II) containing an imidazolyl terpyridine ligand, [Cu(Itpy)(bpy)](ClO(4))(2)·(H(2)O), 1, and [Cu(Itpy)(phen) (ClO(4))](ClO(4))·(H(2)O), 2 have been synthesized and characterized. Complex 1 has been found to possess a distorted square pyramidal geometry whereas 2 exhibit a distorted octahedral geometry. Electronic spectral titrations suggest that 1 and 2 bind to DNA intercalatively with the binding constant, K(b) (4.12 ± 0.13) × 10(4) M(-1) (1) and (6.04 ± 0.15) × 10(4) M(-1) (2). Under physiological condition, in the absence of any external cofactor 2 has been found to bring about DNA cleavage via hydrolytic mechanism but 1 does not bring about any DNA cleavage. Both compounds show antitumor effects on the A549 lung adenocarcinoma cancer cell line.
authors.affiliation: Chemical Laboratory, Central Leather Research Institute, Adyar, Chennai 600 020, India.
authors.forename: Verasuntharam M
authors.initials: VM
authors.lastname: Manikandamathavan
authors.forename: Royapuram P
authors.initials: RP
authors.lastname: Parameswari
authors.forename: Thomas
authors.initials: T
authors.lastname: Weyhermüller
authors.forename: Hannah R
authors.initials: HR
authors.lastname: Vasanthi
authors.forename: Balachandran Unni
authors.initials: BU
authors.lastname: Nair
mesh_terms: D017209:Apoptosis; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D006868:Hydrolysis; D008024:Ligands; D008958:Models, Molecular; D013050:Spectrometry, Fluorescence
chemical_list: D008024:Ligands; D003300:Copper; D004247:DNA