title: Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility.
abstract: Ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. On the other hand, des-acyl ghrelin exerts inhibitory effects on the motility of antrum but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state but not in the fasted state of animals. NPY Y2 and Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptor in the brain may mediate the action of des-acyl ghrelin, whereas CRF type 1 and type 2 receptors in the brain may mediate the action of obestatin.
authors.affiliation: Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan. fujimiya@sapmed.ac.jp
authors.forename: Mineko
authors.initials: M
authors.lastname: Fujimiya
authors.forename: Koji
authors.initials: K
authors.lastname: Ataka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Asakawa
authors.forename: Chih-Yen
authors.initials: CY
authors.lastname: Chen
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kato
authors.forename: Akio
authors.initials: A
authors.lastname: Inui
mesh_terms: D000818:Animals; D004386:Duodenum / Q000502:physiology; D005215:Fasting; D005769:Gastrointestinal Motility / Q000502:physiology*; D015870:Gene Expression; D054439:Ghrelin / Q000008:administration & dosage / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007276:Injections, Intraventricular; D011498:Protein Precursors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011706:Pyloric Antrum / Q000502:physiology; D051381:Rats; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics / Q000378:metabolism; D054440:Receptors, Ghrelin / Q000235:genetics / Q000378:metabolism*; D017476:Receptors, Neuropeptide Y / Q000235:genetics / Q000378:metabolism; D012528:Satiety Response; D015398:Signal Transduction; D000099052:CRF Receptor, Type 1
chemical_list: C101531:CRF receptor type 2; D054439:Ghrelin; D011498:Protein Precursors; D018019:Receptors, Corticotropin-Releasing Hormone; D054440:Receptors, Ghrelin; D017476:Receptors, Neuropeptide Y; C422650:ghrelin, des-n-octanoyl; C095889:neuropeptide Y2 receptor; C109491:neuropeptide Y4 receptor; D000099052:CRF Receptor, Type 1