title: Utility of Quantitative Tc-MAA SPECT/CT for yttrium-Labelled Microsphere Treatment Planning: Calculating Vascularized Hepatic Volume and Dosimetric Approach.
abstract: Objectives. The aim of this study was to assess the effectiveness of SPECT/CT for volume measurements and to report a case illustrating the major impact of SPECT/CT in calculating the vascularized liver volume and dosimetry prior to injecting radiolabelled yttrium-90 microspheres (Therasphere). Materials and Methods. This was a phantom study, involving volume measurements carried out by two operators using SPECT and SPECT/CT images. The percentage of error for each method was calculated, and interobserver reproducibility was evaluated. A treatment using Therasphere was planned in a patient with three hepatic arteries, and the quantitative analysis of SPECT/CT for this patient is provided. Results. SPECT/CT volume measurements proved to be accurate (mean error <6% for volumes ≥16 cm(3)) and reproductive (interobserver agreement = 0.9). In the case report, (99m)Tc-MAA SPECT/CT identified a large liver volume, not previously identified with angiography, which was shown to be vascularized after selective MAA injection into an arterial branch, resulting in a large modification in the activity of Therasphere used. Conclusions. MAA SPECT/CT is accurate for vascularized liver volume measurements, providing a valuable contribution to the therapeutic planning of patients with complex hepatic vascularization.
authors.affiliation: Department of Nuclear Medicine, Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Garin
authors.forename: Yan
authors.initials: Y
authors.lastname: Rolland
authors.forename: Laurence
authors.initials: L
authors.lastname: Lenoir
authors.forename: Marc
authors.initials: M
authors.lastname: Pracht
authors.forename: Habiba
authors.initials: H
authors.lastname: Mesbah
authors.forename: Philippe
authors.initials: P
authors.lastname: Porée
authors.forename: Sophie
authors.initials: S
authors.lastname: Laffont
authors.forename: Bruno
authors.initials: B
authors.lastname: Clement
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Raoul
authors.forename: Eveline
authors.initials: E
authors.lastname: Boucher