title: Measurement of two-dimensional movement parameters of the carotid artery wall for early detection of arteriosclerosis: a preliminary clinical study.
abstract: The aim of this study was to clinically investigate the association between the risk factors of early-stage atherosclerosis and the two-dimensional (2-D) movement of the artery wall. To meet this objective, a speckle tracking approach for the estimation of the 2-D trajectory of the vessel wall was proposed and applied to B-mode ultrasound (US) sequences of the left common carotid artery (CCA). A deformable skeleton model was also introduced in the block matching scheme. Finally, the 2-D movements of both proximal and distal walls were investigated in three different local regions, with 1.5 × 0.3 mm(2) kernel blocks. A clinical study was conducted in which two different populations (26 young healthy volunteers and 26 older diabetic patients) were studied. The results show that the mean amplitude value of the diameter change ΔD, of the longitudinal displacement of the proximal wall ΔX(p) and of the longitudinal displacement of the distal wall ΔX(d) were 0.65 ± 0.17 vs. 0.41 ± 0.12 mm (p < 0.001), 0.48 ± 0.21 vs. 0.26 ± 0.18 mm (p < 0.001) and 0.48 ± 0.20 vs. 0.35 ± 0.23 mm (p = 0.006) for the young healthy volunteers and the older diabetic patients, respectively. The results of the three dynamic parameters ΔD, ΔX(p) and ΔX(d) were systematically and significantly lower for the diabetic subjects, respectively 37%, 46% and 27%. The method introduced in this feasibility study might constitute a pertinent approach to assess the presence of early-stage arteriosclerosis by the noninvasive estimation of the 2-D motion of the intima-media complex in the CCA.
authors.affiliation: Université de Lyon, CREATIS, CNRS UMR 5220, INSERM U1044, INSA-Lyon, France. guillaume.zahnd@creatis.insa-lyon.fr
authors.forename: Guillaume
authors.initials: G
authors.lastname: Zahnd
authors.forename: Loïc
authors.initials: L
authors.lastname: Boussel
authors.forename: Adrien
authors.initials: A
authors.lastname: Marion
authors.forename: Marion
authors.initials: M
authors.lastname: Durand
authors.forename: Philippe
authors.initials: P
authors.lastname: Moulin
authors.forename: André
authors.initials: A
authors.lastname: Sérusclat
authors.forename: Didier
authors.initials: D
authors.lastname: Vray
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014463:Ultrasonography