title: Computer aided diagnosis system for Alzheimer disease using brain diffusion tensor imaging features selected by Pearson's correlation.
abstract: The aim of this paper is to obtain discriminant features from two scalar measures of Diffusion Tensor Imaging (DTI) data, Fractional Anisotropy (FA) and Mean Diffusivity (MD), and to train and test classifiers able to discriminate Alzheimer's Disease (AD) patients from controls on the basis of features extracted from the FA or MD volumes. In this study, support vector machine (SVM) classifier was trained and tested on FA and MD data. Feature selection is done computing the Pearson's correlation between FA or MD values at voxel site across subjects and the indicative variable specifying the subject class. Voxel sites with high absolute correlation are selected for feature extraction. Results are obtained over an on-going study in Hospital de Santiago Apostol collecting anatomical T1-weighted MRI volumes and DTI data from healthy control subjects and AD patients. FA features and a linear SVM classifier achieve perfect accuracy, sensitivity and specificity in several cross-validation studies, supporting the usefulness of DTI-derived features as an image-marker for AD and to the feasibility of building Computer Aided Diagnosis systems for AD based on them.
authors.affiliation: Grupo de Inteligencia Computacional, UPV/EHU, Spain. manuel.grana@ehu.es
authors.forename: M
authors.initials: M
authors.lastname: Graña
authors.forename: M
authors.initials: M
authors.lastname: Termenon
authors.forename: A
authors.initials: A
authors.lastname: Savio
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez-Pinto
authors.forename: J
authors.initials: J
authors.lastname: Echeveste
authors.forename: J M
authors.initials: JM
authors.lastname: Pérez
authors.forename: A
authors.initials: A
authors.lastname: Besga
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology*; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data; D056324:Diffusion Tensor Imaging / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D015233:Models, Statistical; D011237:Predictive Value of Tests; D012986:Software Validation