title: Preparation and characterization of a polymeric blend of PVP/PVAL for use in drug delivery system.
abstract: The aim of the present study was the characterization of a polymeric blend composed of PVP/PVAL that can be used to obtain a biocompatible hydrogel, appropriate as a controlled drug release system. Polymeric blends could be the solution for the creation of new hydrogel, due to the improvement of individual polymer properties. The PVP and PVAL are used as a biocompatible hydrogel because they present high water absorption the main required characteristics for the formation of a hydrogel. This absorption is favored by the presence of the nitrogen of PVP and the hydroxyl of PVAL, and also by the formation of cross-links. Although the PVAL is a synthetic polymer, it is used as a basic material for different applications in biomedicine, once it is non toxic and also not carcinogenic. For this reason, PVP and PVAL were chosen combining the high flexibility of PVP with the mechanical resistance of PVAL, since it will able to form more resistant films. The characterization of the films obtained by mixing mechanically PVP and PVAL at different concentration was carried through several tests as spectroscopy in the infrared region (FTIR), differential scanning calorimetry (DSC) and tensile strength. Increasing the PVAL concentration increases the interaction between the polymers. This can be justified by the results obtained with the tensile test and with the spectrum obtained with the film which contain 0.9 g of PVAL and 0.1 g of PVP that shows the bonds between the polymers.
authors.affiliation: Universidade Presbiteriana Mackenzie, São Paulo, SFP Brazil.
authors.forename: Mauro Cesar
authors.initials: MC
authors.lastname: Terence
authors.forename: Sonia Braunstein
authors.initials: SB
authors.lastname: Faldini
authors.forename: Leila Figueiredo
authors.initials: LF
authors.lastname: de Miranda
authors.forename: Antônio Hortêncio Júnior
authors.initials: AH
authors.lastname: Munhoz
authors.forename: Paula Junqueira
authors.initials: PJ
authors.lastname: de Castro
mesh_terms: D002152:Calorimetry, Differential Scanning; D016503:Drug Delivery Systems; D019344:Lactic Acid / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
chemical_list: D011091:Polyesters; D011108:Polymers; D011145:Polyvinyls; D011759:Pyrrolidines; C505150:poly(N-vinylpyrrolidine); D019344:Lactic Acid; C033616:poly(lactide)