title: Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines.
abstract: A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg, 1, D-52074, Aachen, Germany. Magnus,Rueping@rwth-aachen.de
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping
authors.forename: Thomas
authors.initials: T
authors.lastname: Theissmann
authors.forename: Mirjam
authors.initials: M
authors.lastname: Stoeckel
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Antonchick
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D006865:Hydrogenation; D008958:Models, Molecular; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D011804:Quinolines