title: Shortened treatment duration of glucocorticoid-induced skin atrophy in rats.
abstract: Glucocorticoids (GCs) belong to the most widely used anti-inflammatory drugs at all. However, their topical use is limited by their side effect potential, with skin atrophy being the most prominent one. Thus, determining the atrophogenic potential of novel compounds is of importance for drug development. Currently, the most frequently performed model in the base and pharmaceutical research is the hr/hr rat model of GC-induced skin atrophy that lasts for 19 days. In this study, we analysed statistically skin atrophy experiments retrospectively to ascertain (i) the earliest time-point, at which skin atrophy is significantly induced; and (ii) whether the differences between the GC treatment groups change until the end of the experiment. We show here that the treatment duration of rat skin atrophy models might be reduced to 5 days for economical and ethical reasons.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Schoepe
authors.forename: Richardus
authors.initials: R
authors.lastname: Vonk
authors.forename: Heike
authors.initials: H
authors.lastname: Schäcke
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Zollner
authors.forename: Khusru
authors.initials: K
authors.lastname: Asadullah
authors.forename: Lars
authors.initials: L
authors.lastname: Röse
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001284:Atrophy / Q000139:chemically induced / Q000473:pathology; D002990:Clobetasol / Q000009:adverse effects; D004195:Disease Models, Animal; D005938:Glucocorticoids / Q000009:adverse effects*; D016014:Linear Models; D008775:Methylprednisolone / Q000009:adverse effects; D000068656:Mometasone Furoate; D011244:Pregnadienediols / Q000009:adverse effects; D051381:Rats; D054772:Rats, Hairless; D012867:Skin / Q000187:drug effects* / Q000473:pathology*; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D011244:Pregnadienediols; D000068656:Mometasone Furoate; D002990:Clobetasol; D008775:Methylprednisolone