title: [Preparation and physicochemical properties of vinorelbine liposomes].
abstract: OBJECTIVE
  To prepare the vinorelbine liposomes and investigate their physicochemical properties.
  
  
  METHODS
  Vinorelbine liposomes were prepared by thin-film ultrasonication method. The morphology of the liposomes was detected by transmission electron microscopy. The partical size distribution and zeta potential were investigated by laser scattering. Sephadex G-50 was applied to separate the free drug and liposomes in order to determine the entrapment efficiency and leakage efficiency of the liposomes. The release characteristics of vinorelbine liposomes were measured by dialysis method.
  
  
  RESULTS
  The particle size of the liposome was 149.2 nm, the bilayer of the liposome was observed obviously. The zeta potential was 38.62 mv. The entrapment efficiency of vinorelbine liposomes was more than 85% (n=3), and the leakage efficiency was less than 9.0% preserved in refrigerator ( <4 degrees C). In vitro release test, it could sustain for 24 h and conform to the Higuchi model.
  
  
  CONCLUSIONS
  The vinorelbine liposomes have uniform partical size, fine-looking, high entrapment efficiency and sustained releasing effect.
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China. lixuetao1979@yahoo.cn
authors.forename: Xue-tao
authors.initials: XT
authors.lastname: Li
authors.forename: Lan
authors.initials: L
authors.lastname: Cheng
authors.forename: Tian-zhu
authors.initials: TZ
authors.lastname: Jia
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics; D002627:Chemistry, Physical; D002784:Cholesterol / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D010743:Phospholipids / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D000077235:Vinorelbine
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D014747:Vinblastine; D002784:Cholesterol; D000077235:Vinorelbine