title: A correlative study of quantitative EMG and biopsy findings in 31 patients with myopathies.
abstract: A direct correlation of QEMG with muscle biopsy findings might help delineate the sensitivity of QEMG in identifying muscle pathology as well as provide information on electrophysiological-histological correlations. In a study of 31 patients with a variety of myopathies we found that the sensitivity of QEMG was between 24 to 69% depending of the specific method of signal analysis. The positive predictive value of abnormal QEMG was more than 90% while its negative predictive value was only about 20%. Amplitude outlier analysis was superior especially in minimally weak muscles (MRC > 4) and was particularly sensitive at detecting increased variability in fiber size and more subtle myopathic changes.
authors.affiliation: The Cyprus Institute ofNeurology and Genetics, Nicosia, Cyprus.
authors.forename: E
authors.initials: E
authors.lastname: Dardiotis
authors.forename: E
authors.initials: E
authors.lastname: Papathanasiou
authors.forename: I
authors.initials: I
authors.lastname: Vonta
authors.forename: G
authors.initials: G
authors.lastname: Hadjigeorgiou
authors.forename: E
authors.initials: E
authors.lastname: Zamba-Papanicolaou
authors.forename: T
authors.initials: T
authors.lastname: Kyriakides
mesh_terms: D004576:Electromyography; D006801:Humans; D018482:Muscle, Skeletal / Q000473:pathology*; D009135:Muscular Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity