title: Studies on the synthesis of apoptolidin: synthesis of a C1-C27 fragment of apoptolidin D.
abstract: Synthesis of a C(1)-C(27) fragment, a key intermediate in the synthesis of apoptolidin D, is reported. The synthesis involves a combination of Heck coupling and Horner-Wadsworth-Emmons reaction for the C(1)-C(7) trienoate portion and an efficient Suzuki cross-coupling protocol for the C(10)-C(13) diene portion.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
authors.forename: Madduri
authors.initials: M
authors.lastname: Srinivasarao
authors.forename: Youngsoon
authors.initials: Y
authors.lastname: Kim
authors.forename: Xiaojin Harry
authors.initials: XH
authors.lastname: Li
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Robbins
authors.forename: Philip L
authors.initials: PL
authors.lastname: Fuchs
mesh_terms: D000475:Alkenes / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000475:Alkenes; D018942:Macrolides; C518447:apoptolidin D