title: Practical application of genomics to the development of a topical cosmetic anti-aging regimen.
abstract: The development of topical cosmetic anti-aging products is becoming increasingly sophisticated. This is demonstrated by the benefit agents selected and the scientific approaches used to identify them, treatment protocols that increasingly incorporate multi-product regimens, and the level of rigor in the clinical testing used to demonstrate efficacy. Consistent with these principles, a new cosmetic anti-aging regimen was recently developed. The key product ingredients were identified based on an understanding of the key mechanistic themes associated with aging at the genomic level coupled with appropriate in vitro testing. The products were designed to provide optimum benefits when used in combination in a regimen format. This cosmetic regimen was then tested for efficacy against the appearance of facial wrinkles in a 24-week clinical trial compared with 0.02% tretinoin, a recognized benchmark prescription treatment for facial wrinkling. The cosmetic regimen significantly improved wrinkle appearance after 8 weeks relative to tretinoin and was better tolerated. Wrinkle appearance benefits from the two treatments in cohorts of subjects who continued treatment through 24 weeks were also comparable.
authors.affiliation: The Procter & Gamble Company, Cincinnati, OH, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Kaczvinsky
authors.forename: Vince
authors.initials: V
authors.lastname: Bertucci
authors.forename: Juian-juian Jan
authors.initials: JJ
authors.lastname: Fu
mesh_terms: D000328:Adult; D000368:Aged; D003358:Cosmetics / Q000494:pharmacology*; D005260:Female; D023281:Genomics / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D015595:Skin Aging / Q000187:drug effects*; D014212:Tretinoin / Q000494:pharmacology
chemical_list: D003358:Cosmetics; D014212:Tretinoin