title: In utero exposure to air pollution lowers erythrocyte antioxidant defense and decreases weight in adult mice.
abstract: In this study, we tested the influence of ambient air pollution on different phases of development of adult mice. With respect to adult weight, the animals that had spent their in utero period exposed to pollution showed less weight gain over their lifetime, as well as lower activity levels of the antioxidant enzymes catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx). Our study suggests that contact with atmospheric pollutants during the foetal period produces important changes on enzymatic erythrocyte antioxidant defense and weight in adult mice.
authors.affiliation: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Karina Camasmie
authors.initials: KC
authors.lastname: Abe
authors.forename: Letícia
authors.initials: L
authors.lastname: de Campos Brandão
authors.forename: Sérgio
authors.initials: S
authors.lastname: Tufik
authors.forename: Paulo Hilário
authors.initials: PH
authors.lastname: do Nascimento Saldiva
authors.forename: Vânia
authors.initials: V
authors.lastname: D'Almeida
mesh_terms: D000393:Air Pollutants / Q000494:pharmacology*; D000397:Air Pollution / Q000009:adverse effects*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002374:Catalase; D002648:Child; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007223:Infant; D018811:Maternal Exposure / Q000009:adverse effects*; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000393:Air Pollutants; D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase