title: [High resistance of bacterial strains Streptococcus agalactiae to antibiotic therapy in early-onset and late-onset disease in newborns].
abstract: OBJECTIVE
  The resistance of S. agalactiae strains to macrolide and lincosamide antibiotics in newborns and their mothers.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Laboratory of Clinical Microbiology and Antibiotic Centre, Department of Clinical Biochemistry and Laboratory Diagnostics, General Teaching Hospital, Prague.
  
  
  METHODS
  In newborns in General Teaching Hospital in Prague between the years 2007 and 2009 we found 79 patients with S. agalactiae. Erythromycin and clindamycin were used in disk diffusion testing.
  
  
  RESULTS
  In the collection of the children with early and late S. agalactiae infection was proved the same level of resistance to erythromycin and clindamycin - 39% (resp. 40%).
  
  
  CONCLUSIONS
  Macrolide and lincosamide antibiotics cannot be used for antibiotic prophylaxis during delivery without knowledge of the antibiotic susceptibility testing result due to the high level of the antibiotic resistance of Streptococcus agalactiae strains.
authors.affiliation: Laborator klinické mikrobiologie a ATB centrum, Ustav klinické biochemie a laboratorní diagnostiky VFN, Praha. daniela.balikova@vfn.cz
authors.forename: D
authors.initials: D
authors.lastname: Balíková
authors.forename: V
authors.initials: V
authors.lastname: Adámková
authors.forename: J
authors.initials: J
authors.lastname: Svobodová
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D006801:Humans; D007231:Infant, Newborn; D055231:Lincosamides / Q000627:therapeutic use; D018942:Macrolides / Q000627:therapeutic use; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D055231:Lincosamides; D018942:Macrolides