title: Dual effects of caffeoyl-amino acidyl-hydroxamic acid as an antioxidant and depigmenting agent.
abstract: Anti-aging and depigmentation have both been an important subject of study for skin disease and the cosmetic industry. Caffeic acid (CA) has shown synergistically enhanced antioxidant activity when conjugated with amino acids. Hydroxamic acid (NHOH) is a well-known metal chelator, potentially having both tyrosinase inhibitory activity and free radical scavenging activity. We prepared caffeoyl-amino acidyl-hydroxamic acid (CA-Xaa-NHOH) and found that caffeoyl-prolyl-hydroxamic acid (CA-Pro-NHOH) contained excellent antioxidant activity and tyrosinase inhibitory activity by various bioassay systems. Also, CA-Pro-NHOH showed mild melanogenesis inhibitory activity in Mel-Ab cells.
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
authors.forename: Seon-Yeong
authors.initials: SY
authors.lastname: Kwak
authors.forename: Song
authors.initials: S
authors.lastname: Lee
authors.forename: Hye-Ryung
authors.initials: HR
authors.lastname: Choi
authors.forename: Kyung-Chan
authors.initials: KC
authors.lastname: Park
authors.forename: Yoon-Sik
authors.initials: YS
authors.lastname: Lee
mesh_terms: D000363:Agaricales / Q000201:enzymology; D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006877:Hydroxamic Acids / Q000737:chemistry / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D012880:Skin Pigmentation / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D000975:Antioxidants; D002109:Caffeic Acids; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D014442:Monophenol Monooxygenase; C040048:caffeic acid