title: FDG uptake in lipomatous hypertrophy of the interatrial septum is not likely related to brown adipose tissue.
abstract: Lipomatous hypertrophy of the interatrial septum (LHIS) may be associated with arrhythmias or sudden death. Increased fluorine-18 fluorodeoxyglucose (FDG) uptake in LHIS is occasionally found on positron emission tomography, and has been attributed to metabolically active brown adipose tissue (BAT) contained within LHIS. We report a case of a patient suggesting that neither of the 2 currently known mechanisms of glucose uptake by BAT is responsible for FDG uptake in LHIS, unless a mechanism of BAT activation exists that has not been previously described. This study also suggests that FDG uptake is unlikely to be due to cardiomyocytes contained within LHIS. Inflammation is a potential mechanism, although further investigation is needed.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Zukotynski
authors.forename: David A
authors.initials: DA
authors.lastname: Israel
authors.forename: Chun K
authors.initials: CK
authors.lastname: Kim
mesh_terms: D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging*; D000369:Aged, 80 and over; D054087:Atrial Septum / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D006984:Hypertrophy; D008067:Lipoma / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
chemical_list: D019788:Fluorodeoxyglucose F18