title: Limited clinical activity of nilotinib and sorafenib in FIP1L1-PDGFRA positive chronic eosinophilic leukemia with imatinib-resistant T674I mutation.
authors.forename: G
authors.initials: G
authors.lastname: Metzgeroth
authors.forename: P
authors.initials: P
authors.lastname: Erben
authors.forename: H
authors.initials: H
authors.lastname: Martin
authors.forename: S
authors.initials: S
authors.lastname: Mousset
authors.forename: M
authors.initials: M
authors.lastname: Teichmann
authors.forename: C
authors.initials: C
authors.lastname: Walz
authors.forename: T
authors.initials: T
authors.lastname: Klippstein
authors.forename: A
authors.initials: A
authors.lastname: Hochhaus
authors.forename: N C P
authors.initials: NC
authors.lastname: Cross
authors.forename: W-K
authors.initials: WK
authors.lastname: Hofmann
authors.forename: A
authors.initials: A
authors.lastname: Reiter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D001557:Benzenesulfonates / Q000627:therapeutic use*; D002908:Chronic Disease; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000188:drug therapy* / Q000235:genetics; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D010879:Piperazines / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics*; D000077157:Sorafenib; D039221:mRNA Cleavage and Polyadenylation Factors / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D001557:Benzenesulfonates; C479818:FIP1L1 protein, human; D010671:Phenylurea Compounds; D010879:Piperazines; D011725:Pyridines; D011743:Pyrimidines; D039221:mRNA Cleavage and Polyadenylation Factors; D009536:Niacinamide; D000068877:Imatinib Mesylate; D000077157:Sorafenib; D020796:Receptor, Platelet-Derived Growth Factor alpha; C498826:nilotinib