title: [Correlation between the quantity of oral mucosal micronucleus cells and cancerization].
abstract: OBJECTIVE
  To explore the relationship between micronuclei and malignant development of oral epithelial dysplasia (OED).
  
  
  METHODS
  Oral exfoliated cells were smeared from 30 control subjects, 46 patients with oral lichen planus (OLP), 78 patients with oral leukoplakia (OLK) and hyperplasia, 30 patients with OLK and mild OED, 29 patients with OLK and moderate OED, 15 patients with OLK and severe OED and 22 patients with oral squamous cell carcinoma (OSCC).
  
  
  RESULTS
  Micronucleus rates declined according to the order of OSCC, OLK and severe OED, OLK and moderate OED, OLK and mild OED, OLK and hyperplasia, OLP and control groups (P<0.001).
  
  
  CONCLUSIONS
  Micronuclei may reflect the progression of oral epithelial malignant changes. It could be used in monitoring cancerization in following up cases regularly.
authors.affiliation: Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100034, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Liu
authors.forename: Xiao-song
authors.initials: XS
authors.lastname: Liu
authors.forename: Jian-qiu
authors.initials: JQ
authors.lastname: Jin
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007972:Leukoplakia, Oral / Q000378:metabolism / Q000473:pathology; D017676:Lichen Planus, Oral / Q000378:metabolism / Q000473:pathology*; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*