title: Patient-specific prediction of intrinsic mechanical loadings on sub-muscular pectoral pacemaker implants based on an inter-species transfer function.
abstract: With the steady technological development enabling reduced device dimensions and new patient populations, detailed data on mechanical in vivo loads become increasingly important to ensure reliability of implantable medical devices. Based on an intra-species correlation of in-line and transverse force of the Pectoralis major established previously for the Chacma baboon (de Vaal et al., 2010a), a simplified physiological model and a mechanical equivalent model were developed for a sub-muscular pectoral device implant considering Pectoralis major, Pectoralis minor and rib cage. By assessing the morphometric and mechanical parameters of these musculo-skeletal structures and the associated model parameters, the intra-species correlation was shown to exhibit (a) robustness for a larger intra-species subject population and (b) linear scale variance allowing application for humans under consideration of the inter-species difference of the attachment angles of Pectoralis major. The transfer function provides a basis for the prediction of patient-specific maximum mechanical loadings on a sub-muscular pectoral cardiac pacemaker implant through non- or minimal invasive measurements on the patient.
authors.affiliation: Cardiovascular Research Unit, Chris Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa.
authors.forename: Michael Hamman
authors.initials: MH
authors.lastname: de Vaal
authors.forename: James
authors.initials: J
authors.lastname: Neville
authors.forename: Micah
authors.initials: M
authors.lastname: Litow
authors.forename: Jacques
authors.initials: J
authors.lastname: Scherman
authors.forename: Peter
authors.initials: P
authors.lastname: Zilla
authors.forename: Thomas
authors.initials: T
authors.lastname: Franz
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D004576:Electromyography; D006801:Humans; D010138:Pacemaker, Artificial; D010215:Papio; D010369:Pectoralis Muscles / Q000033:anatomy & histology* / Q000502:physiology; D019736:Prostheses and Implants; D015203:Reproducibility of Results