title: Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma.
abstract: The delivery of curcumin, a broad-spectrum anticancer drug, has been explored in the form of liposomal nanoparticles to treat osteosarcoma (OS). Curcumin is water insoluble and an effective delivery route is through encapsulation in cyclodextrins followed by a second encapsulation in liposomes. Liposomal curcumin's potential was evaluated against cancer models of mesenchymal (OS) and epithelial origin (breast cancer). The resulting 2-Hydroxypropyl-γ-cyclodextrin/curcumin - liposome complex shows promising anticancer potential both in vitro and in vivo against KHOS OS cell line and MCF-7 breast cancer cell line. An interesting aspect is that liposomal curcumin initiates the caspase cascade that leads to apoptotic cell death in vitro in comparison with DMSO-curcumin induced autophagic cell death. In addition, the efficiency of the liposomal curcumin formulation was confirmed in vivo using a xenograft OS model. Curcumin-loaded γ-cyclodextrin liposomes indicate significant potential as delivery vehicles for the treatment of cancers of different tissue origin.
  
  
  BACKGROUND
  Curcumin-loaded γ-cyclodextrin liposomes were demonstrated in vitro to have significant potential as delivery vehicles for the treatment of cancers of mesenchymal and epithelial origin. Differences between mechanisms of cell death were also evaluated.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Louisiana, USA.
authors.forename: Santosh S
authors.initials: SS
authors.lastname: Dhule
authors.forename: Patrice
authors.initials: P
authors.lastname: Penfornis
authors.forename: Trivia
authors.initials: T
authors.lastname: Frazier
authors.forename: Ryan
authors.initials: R
authors.lastname: Walker
authors.forename: Joshua
authors.initials: J
authors.lastname: Feldman
authors.forename: Grace
authors.initials: G
authors.lastname: Tan
authors.forename: Jibao
authors.initials: J
authors.lastname: He
authors.forename: Alina
authors.initials: A
authors.lastname: Alb
authors.forename: Vijay
authors.initials: V
authors.lastname: John
authors.forename: Radhika
authors.initials: R
authors.lastname: Pochampally
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy / Q000648:ultrastructure; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008081:Liposomes; D051379:Mice; D008819:Mice, Nude; D009363:Neoplasm Proteins / Q000378:metabolism; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000188:drug therapy* / Q000648:ultrastructure; D014183:Transplantation, Heterologous; D023041:Xenograft Model Antitumor Assays; D047408:gamma-Cyclodextrins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D009363:Neoplasm Proteins; D047408:gamma-Cyclodextrins; D020169:Caspases; D003474:Curcumin