title: Antimicrobial activity against bacteria with dermatological relevance and skin tolerance of the essential oil from Coriandrum sativum L. fruits.
abstract: The aim of this work was to determine the antibacterial activity of essential coriander oil (ECO) on bacteria with dermatological relevance and to assess the skin tolerance of antimicrobial effective ECO concentrations. Essential coriander oil was tested on clinical isolates of different bacteria species, all of which may cause superficial skin infections. Antimicrobial susceptibility testing was performed using a standardized macrodilution test. Essential coriander oil showed good antibacterial activity towards the majority of the bacterial strains tested, including Streptococcus pyogenes (Lancefield group A) and methicillin resistant Staphylococcus aureus (MRSA), with mean minimal inhibitory concentrations of 0.04% v/v and 0.25% v/v, respectively. The skin tolerance of a cream and a lotion containing 0.5% and 1.0% ECO was assessed in 40 healthy volunteers using the occlusive patch test. No skin irritation could be observed by sensitive photometric assessment in any of the volunteers. Because of its activity against Streptococcus pyogenes, Staphylococcus aureus and MRSA combined with excellent skin tolerance, ECO might be useful as an antiseptic for the prevention and treatment of skin infections with Gram-positive bacteria.
authors.affiliation: Competence Centre skintegral®, Department of Dermatology, University Medical Centre Freiburg, Hauptstrasse 7, D-79104 Freiburg, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Casetti
authors.forename: S
authors.initials: S
authors.lastname: Bartelke
authors.forename: K
authors.initials: K
authors.lastname: Biehler
authors.forename: M
authors.initials: M
authors.lastname: Augustin
authors.forename: C M
authors.initials: CM
authors.lastname: Schempp
authors.forename: U
authors.initials: U
authors.lastname: Frank
mesh_terms: D000080462:Acyclic Monoterpenes; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology; D028526:Coriandrum / Q000737:chemistry*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010328:Patch Tests; D011446:Prospective Studies; D017192:Skin Diseases, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000187:drug effects; D055815:Young Adult
chemical_list: D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D039821:Monoterpenes; D009822:Oils, Volatile; C018584:linalool