title: Genetic testing for early detection of individuals at risk of coronary heart disease and monitoring response to therapy: challenges and promises.
abstract: Coronary heart disease (CHD) often presents suddenly with little warning. Traditional risk factors are inadequate to identify the asymptomatic high-risk individuals. Early identification of patients with subclinical coronary artery disease using noninvasive imaging modalities would allow the early adoption of aggressive preventative interventions. Currently, it is impractical to screen the entire population with noninvasive coronary imaging tools. The use of relatively simple and inexpensive genetic markers of increased CHD risk can identify a population subgroup in which benefit of atherosclerotic imaging modalities would be increased despite nominal cost and radiation exposure. Additionally, genetic markers are fixed and need only be measured once in a patient's lifetime, can help guide therapy selection, and may be of utility in family counseling.
authors.affiliation: Celera Corporation, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA. HighHDL@mac.com
authors.forename: H Robert
authors.initials: HR
authors.lastname: Superko
authors.forename: Robert
authors.initials: R
authors.lastname: Roberts
authors.forename: Arthur
authors.initials: A
authors.lastname: Agatston
authors.forename: Stephen
authors.initials: S
authors.lastname: Frohwein
authors.forename: Jason S
authors.initials: JS
authors.lastname: Reingold
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: White
authors.forename: John J
authors.initials: JJ
authors.lastname: Sninsky
authors.forename: Basil
authors.initials: B
authors.lastname: Margolis
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Momary
authors.forename: Brenda C
authors.initials: BC
authors.lastname: Garrett
authors.forename: Spencer B
authors.initials: SB
authors.lastname: King
mesh_terms: D000483:Alleles; D003327:Coronary Disease / Q000235:genetics* / Q000628:therapy*; D003952:Diagnostic Imaging; D042241:Early Diagnosis; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008403:Mass Screening; D010641:Phenotype; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors