title: [Study of cajal interstitial cells in stomach and small intestine of rats with crude, honey-stir-baked radix polygalae and its saponins].
abstract: OBJECTIVE
  To observe the changes of interstitial cells of Cajal (ICC) in stomach and small intestine of rats with honey-stir-baked Radix Polygalae, crude Radix Polygalae and its saponins, so as to study mechanism of crude Radix Polygalae reducing the motility disorder in gastrointestinal tract.
  
  
  METHODS
  Immunohistochemical staining was used to investigate the distribution of c-kit positive ICC in stomach and small intestine.
  
  
  RESULTS
  Compared with control group, the c-kit positive ICC in stomach and small intestine of crude Radix Polygalae and its saponins groups were both markedly decreased in model group (both P < 0.01), while honey-stir-baked Radix Polygalae group can not (P > 0.05).
  
  
  CONCLUSIONS
  The motility disorder in gastrointestinal tract caused by crude Radix Polygalae and its saponins may be associated with the changes of ICC number in stomach and small intestine. Honey-stir-baked Radix Polygalae can protect ICC in some extent.
authors.affiliation: Pharmacy College, Hubei University of Traditional Chinese Medicine, Wuhan 430065, China. sunzhuyang@126.com
authors.forename: Wei-feng
authors.initials: WF
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Li-na
authors.initials: LN
authors.lastname: Liu
authors.forename: Wu
authors.initials: W
authors.lastname: Xiao
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000473:pathology; D005769:Gastrointestinal Motility / Q000187:drug effects; D006722:Honey; D007150:Immunohistochemistry; D056885:Interstitial Cells of Cajal / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009130:Muscle, Smooth / Q000473:pathology; D018517:Plant Roots / Q000737:chemistry; D031801:Polygala / Q000009:adverse effects / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000009:adverse effects*; D013194:Staining and Labeling; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins