title: [The protective of Shenfu injections on hemodynamics and myocardial enzyme after myocardial ischemia/reperfusion injury].
abstract: OBJECTIVE
  To study the protective effect of Shenfu (Chinese traditional medicine) injections on myocardial ischemia/reperfusion (I/R) injury in rabbits.
  
  
  METHODS
  Thirty rabbits were divided into three groups (n = 10) randomly: control group, myocardial ischemia/ reperfusion group (MI/RI) and Shenfu injections extract group, three groups of rabbits were fed respectively with standard diet. After giving medicine 10 minutes, the myocardial ischemia/reperfusion injury animal model was established by ligaturing rabbits left ventricutar branch of coronary artery, and observing the changes of enzyme/hemodynamics during myocardial ischemia/reperfusion.
  
  
  RESULTS
  In model group myocardial function of shrink went down, the amount of malondialdehyde (MDA) was higher, the activity of superoxide dismutase (SOD), glutathine peroxidease (GSH-Px), Na(+) -K(+) -ATP and Ca(2+) -ATP were lower, lactic dehydrogenase (LDH) and creatine kinase(CK) were released compared with those in model group. Shenfu injections could recover left ventricular systolic pressure (LVSP) and +/- dp/dt(max), decrease left ventricular end-diastolic pressure(LVEDP), inhibit the increasing of MDA, LDH and CK, and increase the activaty of SOD, GSH-PX, Na(+) -K(+) -ATP and Ca(2+) -ATP.
  
  
  CONCLUSIONS
  Shenfu injections can obviously protect myocardial ischemia/reperfusion injury.
authors.affiliation: Medical School of Hubei Institute for Nationalities, Enshi 445000, China. wang-zhong-jie@163.com
authors.forename: Zhen-Fu
authors.initials: ZF
authors.lastname: Wang
mesh_terms: D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000201:enzymology*; D011817:Rabbits; D011897:Random Allocation; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; C492793:Shen-Fu; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase