title: Antimicrobial, antileishmanial and cytotoxic compounds from Piper chaba.
abstract: The petroleum ether and chloroform extracts of the root of Piper chaba showed antimicrobial, antileishmanial and cytotoxic activities. Further bioactivity-guided fractionation led to the isolation of Bornyl piperate (1), piperlonguminine (2) and piperine (3). This is the first report of isolation of compounds (1) and (2) from P. chaba. It was observed that the isolated compounds (1 and 2) showed potent antifungal activity when compared with standard drug Nystatin, and significant cytotoxic activity with the IC₅₀ values of 0.76 and 0.83 µg mL⁻¹, respectively. These compounds were also found to have weak antibacterial and antileishmanial activities. This is the first report about the antileishmanial activity of Piper isolates.
authors.affiliation: Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.
authors.forename: Tarannum
authors.initials: T
authors.lastname: Naz
authors.forename: Ashik
authors.initials: A
authors.lastname: Mosaddik
authors.forename: Motiur
authors.initials: M
authors.lastname: Rahman
authors.forename: Ilias
authors.initials: I
authors.lastname: Muhammad
authors.forename: Ekramul
authors.initials: E
authors.lastname: Haque
authors.forename: Somi Kim
authors.initials: SK
authors.lastname: Cho
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002853:Chromatography, Liquid; D007891:Leishmania / Q000187:drug effects*; D031701:Piper / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents