title: Total synthesis of (-)-nakadomarin A.
abstract: A highly diastereoselective bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, a furan N-acyliminium cyclisation, a sequential alkyne RCM/syn-reduction and an alkene RCM has allowed a 19 step, highly stereoselective synthesis of (-)-nakadomarin A.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, United Kingdom.
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Kyle
authors.forename: Pavol
authors.initials: P
authors.lastname: Jakubec
authors.forename: Dane M
authors.initials: DM
authors.lastname: Cockfield
authors.forename: Ed
authors.initials: E
authors.lastname: Cleator
authors.forename: John
authors.initials: J
authors.lastname: Skidmore
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Dixon
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D002243:Carbolines; C476640:nakadomarin A