title: [Successful treatment of invasive pulmonary aspergillosis with a fungus ball and infiltration by the long-term administration of liposomal amphotericin B].
abstract: A 64-year-old diabetic man was admitted because his general condition had not improved despite the admini stration of voriconazole in another hospital, and his condition had become critical. Chest CT demonstrated a large fungus ball and consolidation around a cavity in the right lung. Aspergillusfumigatus was detected on a sputum culture. Based on these findings, we diagnosed invasive aspergillosis and administered high-dose (5mg/kg) liposomal amphotericin B (L-AMB) for 8 weeks, which resulted in the improvement of his general condition and the disappearance of the fungus ball, without severe adverse events.
authors.affiliation: Division of Respiratory Medicine, Matsusaka Municipal Hospital.
authors.forename: Osamu
authors.initials: O
authors.lastname: Hataji
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Komada
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Osamu
authors.initials: O
authors.lastname: Taguchi
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D006801:Humans; D008081:Liposomes; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D055732:Pulmonary Aspergillosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B