title: [Osteoarticular brucellosis: an analysis of the past decade].
abstract: OBJECTIVE
  Characterize Osteoarticular Brucellosis in the University Hospital of Coimbra (HUC) in the past decade.
  
  
  METHODS
  A retrospective study of the cases diagnosed between January/2000 and December/2009 in the HUC.
  
  
  RESULTS
  Ninety patients were admitted with the dia-gnosis of brucellosis in our hospital, of whom 44 (49%; 18 men; 26 women, mean 49.5 years) had osteoarticular complications. Twenty-five (45%) patients had a positive epidemiological context. The most frequent clinical manifestation was local pain (73%) followed by polyarthralgias and constitutional symptoms. The C-reactive protein was the inflammatory marker most often increased (82%). The Rose Bengala test was positive in 42 patients, and a Wright's sero-aglutination above than 1/160 was detected in 28 patients. An etiologic agent was isolated in 28 (64%) patients, with 70% of positive blood cultures. The imaging procedure of choice was magnetic resonance imaging (MRI) (46%). The osteo-articular manifestation most frequent was spondylodiscitis (57%) with a lumbosacral involvement in 40%. All patients completed antibiotic therapy. One patient underwent surgery to drain the abscess. Patients had an average length of admission of 28.3 days, with a good outcome in 60%, and a reasonable outcome in 20%, despite 20% of the patients lost follow-up.
  
  
  CONCLUSIONS
  Brucellosis is a disease of obligatory declaration not eradicated in Portugal, with a great impact on socio-economic and public health. So, this epidemiological knowledge of brucellosis cases, allows an early intervention and therapy.
authors.affiliation: Hospitais da Universidade de Coimbra, Portugal. tlousasantiago@hotmail.com
authors.forename: T
authors.initials: T
authors.lastname: Santiago
authors.forename: J
authors.initials: J
authors.lastname: Rovisco
authors.forename: J
authors.initials: J
authors.lastname: Silva
authors.forename: J A
authors.initials: JA
authors.lastname: Pereira da Silva
mesh_terms: D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000382:microbiology*; D002006:Brucellosis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies