title: A genome-wide association study identifies two new risk loci for Graves' disease.
abstract: Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex, TSHR, CTLA4 and FCRL3) and identified two new susceptibility loci (the RNASET2-FGFR1OP-CCR6 region at 6q27 (P(combined) = 6.85 × 10(-10) for rs9355610) and an intergenic region at 4p14 (P(combined) = 1.08 × 10(-13) for rs6832151)). These newly associated SNPs were correlated with the expression levels of RNASET2 at 6q27, of CHRNA9 and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.
authors.affiliation: State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Chu
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Pan
authors.forename: Shuang-Xia
authors.initials: SX
authors.lastname: Zhao
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.forename: Guan-Qi
authors.initials: GQ
authors.lastname: Gao
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Guo-Yue
authors.initials: GY
authors.lastname: Yuan
authors.forename: Chang-Gui
authors.initials: CG
authors.lastname: Li
authors.forename: Li-Qiong
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authors.lastname: Xue
authors.forename: Min
authors.initials: M
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.forename: Shao-Ying
authors.initials: SY
authors.lastname: Yang
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wang
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Shi
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Sun
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Du
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Zuo
authors.forename: Jin-Xiu
authors.initials: JX
authors.lastname: Shi
authors.forename: Bing-Li
authors.initials: BL
authors.lastname: Liu
authors.forename: Cui-Cui
authors.initials: CC
authors.lastname: Guo
authors.forename: Ming
authors.initials: M
authors.lastname: Zhan
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Gu
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Sun
authors.forename: Zhi-Quan
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Zhi-Yi
authors.initials: ZY
authors.lastname: Song
authors.forename: Cai-Yan
authors.initials: CY
authors.lastname: Zou
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Sun
authors.forename: Ting
authors.initials: T
authors.lastname: Guo
authors.forename: Huang-Ming
authors.initials: HM
authors.lastname: Cao
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Ma
authors.forename: Bing
authors.initials: B
authors.lastname: Han
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: He
authors.initials: H
authors.lastname: Jiang
authors.forename: Qiu-Hua
authors.initials: QH
authors.lastname: Huang
authors.forename: Liming
authors.initials: L
authors.lastname: Liang
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Su
authors.forename: Yong-De
authors.initials: YD
authors.lastname: Peng
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Zhao
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
authors.forename: Zhu
authors.initials: Z
authors.lastname: Chen
authors.forename: Jia-Lun
authors.initials: JL
authors.lastname: Chen
authors.forename: Sai-Juan
authors.initials: SJ
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Huai-Dong
authors.initials: HD
authors.lastname: Song
mesh_terms: D001323:Autoantibodies / Q000097:blood; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006111:Graves Disease / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011989:Receptors, Thyrotropin / Q000235:genetics* / Q000276:immunology; D012306:Risk
chemical_list: D001323:Autoantibodies; D000949:Histocompatibility Antigens Class II; D011989:Receptors, Thyrotropin