title: A mathematical model for the effects of HER2 over-expression on cell cycle progression in breast cancer.
abstract: In this paper, we present a mathematical model predicting the fraction of proliferating cells in G1, S, and G2/M phases of the cell cycle as a function of EGFR and HER2. We show that it is possible to find parameters for the mathematical model so that its predictions agree with the experimental observations that HER2 over-expression results in: (1) a shorter G1-phase and early S-phase entry; (2) and that with a 1-to-1 ration between EGFR and HER2, the growth advantage in HER2 over-expressing cells is indeed associated with the increase of the HER2 expression level.
authors.affiliation: The College of Saint Rose, 432 Western Avenue, Albany, NY 12203, USA. eladdada@strose.edu
authors.forename: Amina
authors.initials: A
authors.lastname: Eladdadi
authors.forename: David
authors.initials: D
authors.lastname: Isaacson
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D002453:Cell Cycle / Q000235:genetics*; D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D018734:Genes, erbB-2; D006801:Humans; D055641:Mathematical Concepts; D008954:Models, Biological; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism
chemical_list: D066246:ErbB Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human