title: The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory.
abstract: MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory.
authors.affiliation: Intellectual Development and Disabilities Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
authors.forename: Quan
authors.initials: Q
authors.lastname: Lin
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Coelho
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Danay
authors.initials: D
authors.lastname: Baker-Andresen
authors.forename: Kevin
authors.initials: K
authors.lastname: Dudley
authors.forename: Vikram S
authors.initials: VS
authors.lastname: Ratnu
authors.forename: Zoran
authors.initials: Z
authors.lastname: Boskovic
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kobor
authors.forename: Yi E
authors.initials: YE
authors.lastname: Sun
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Bredy
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000378:metabolism*; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D002461:Cell Line, Transformed; D003214:Conditioning, Classical; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005108:Extinction, Psychological / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005239:Fear; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011189:Potassium Chloride / Q000494:pharmacology; D054645:Protein Phosphatase 1 / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D014161:Transduction, Genetic / Q000379:methods; D014162:Transfection
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; C492004:Creb1 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D016326:Extracellular Matrix Proteins; D035683:MicroRNAs; C550324:Mirn128 microRNA, mouse; D009419:Nerve Tissue Proteins; D034741:RNA, Small Interfering; D000091042:Reelin Protein; D015534:Trans-Activators; D011189:Potassium Chloride; D054645:Protein Phosphatase 1; D012697:Serine Endopeptidases