title: [Cardiovascular risk factors and apolipoproteic profile in a group of adults treated in a public health center in Carabobo state, Venezuela].
abstract: OBJECTIVE
  To compare serum levels of apolipoproteins A-I and B as well as Apo B/Apo A-I and HDL cholesterol/Apo A-I ratios by age, gender and cardiovascular risk factors in individuals treated at a Venezuelan public health center.
  
  
  METHODS
  We determined in 221 individuals (44.0 ± 15.5 years) of both genders blood pressure, waist circumference (WC), lipid profile and apolipoproteins A-I and B; body mass index (BMI) was calculated from weight and height; smoking habit, alcohol intake and consumption pattern were established.
  
  
  RESULTS
  27.5% of individuals had low levels of Apo A-I, 45.2% high Apo B and 60.6% high Apo B/Apo A-I ratio. Serum levels of apolipoproteins and Apo B/Apo A-I ratio did not vary with age or gender, while the ratio HDL cholesterol/Apo A-I decreased with the age. Obese individuals, smokers, hypertensive, hypercholesterolemics, hypertriglyceridemics or with low HDL cholesterol showed higher Apo B and Apo B/Apo A-I ratio. Older individuals, smokers or individuals with increased LDL cholesterol and triglycerides showed lower HDL cholesterol/Apo A-I ratio. Consumption of three or more alcoholic drinks/day was associated with decreased Apo B.
  
  
  CONCLUSIONS
  These results show high prevalence of altered apolipoprotein profile, which is associated with major cardiovascular risk factors. The results support the inclusion of the evaluated apolipoproteins in laboratory determinations made in public health centers in Venezuela.
authors.affiliation: Departamento de Morfofisiopatología, Escuela de Bioanálisis Sede Carabobo, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela. nelinaruiz@yahoo.com
authors.forename: Nelina
authors.initials: N
authors.lastname: Ruiz
authors.forename: Valerie
authors.initials: V
authors.lastname: Castillo
authors.forename: Francys
authors.initials: F
authors.lastname: Colina
authors.forename: Milagros
authors.initials: M
authors.lastname: Espinoza
authors.forename: Ulises
authors.initials: U
authors.lastname: Leal
authors.forename: Julio César
authors.initials: JC
authors.lastname: Gonzalez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001053:Apolipoproteins / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006268:Health Facilities; D006801:Humans; D008297:Male; D008875:Middle Aged; D011634:Public Health; D012307:Risk Factors; D014687:Venezuela; D055815:Young Adult
chemical_list: D001053:Apolipoproteins