title: Isolated lateral thalamic infarction: the role of posterior cerebral artery disease.
abstract: OBJECTIVE
  Lateral thalamic infarction (LTI) is usually caused by small vessel disease (SVD), i.e., occlusion of the deep perforator. However, focal atherosclerotic posterior cerebral artery disease (PCAD) may produce LTI via thrombotic occlusion of the perforator. We aimed to investigate the prevalence of PCAD in LTI and differences in clinical and imaging findings between LTIs associated with PCAD and SVD.
  
  
  METHODS
  We retrospectively evaluated 58 consecutive patients with isolated LTI who underwent diffusion-weighted imaging (DWI) and MR angiography (MRA) within 7 days after stroke onset. Patients were divided into two groups: those with PCAD and those with SVD. Clinical syndromes were divided into pure sensory stroke (PSS) and sensory stroke plus (SS-plus), i.e., the concomitant presence of motor dysfunction or ataxia. Clinical and imaging findings were compared between these two groups.
  
  
  RESULTS
  Of the 58 patients, 13 (22.4%) had PCAD. PSS was more frequently associated with SVD than with PCAD (57.8% vs. 23.1%, P=0.032). Initial DWI lesion volume (cm³) was significantly larger in PCAD than in patients with SVD (0.38±0.13 vs. 0.33±0.22, P=0.025). Among the 23 patients (39.7%) who underwent follow-up DWI, patients with PCAD showed a significantly greater increase in subacute lesion volume than those with SVD (P=0.019). Although National Institutes of Health Stroke Scale scores did not differ at admission (P=0.185), they were significantly higher at discharge in PCAD than in patients with SVD (P=0.012).
  
  
  CONCLUSIONS
  Our data suggest that PCAD is an important cause of LTI, being related to SS-plus, larger lesion volume, and worse clinical outcomes.
authors.affiliation: Stroke Center and Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, South Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Kwon
authors.forename: S U
authors.initials: SU
authors.lastname: Kwon
authors.forename: D-W
authors.initials: DW
authors.lastname: Kang
authors.forename: D C
authors.initials: DC
authors.lastname: Suh
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002539:Cerebral Arterial Diseases / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D020762:Infarction, Posterior Cerebral Artery / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020769:Posterior Cerebral Artery / Q000473:pathology*; D012189:Retrospective Studies; D013788:Thalamus / Q000473:pathology* / Q000503:physiopathology