title: Cellular immune responses in Echinostoma caproni experimentally infected mice.
abstract: The Echinostoma caproni-mice system is extensively used as an experimental model for the study of the factors involved in the establishment of chronic intestinal helminth infections. Although several parameters of the immunobiology of the host-parasite system have been studied in detail, the current knowledge of the cellular responses in these infections is still scarce. In the present paper, we analyze the kinetics of the circulating CD3(+) and CD19(+) cell populations and the different T-cell phenotype profiles in mice experimentally infected with E. caproni. Whereas the CD3(+) populations remained stable during the complete experiment, a marked increase in CD19(+) cells was observed from 4 weeks post-infection and beyond. Similarly, a marked increase in CD8(+) cell populations was observed in the 2 week post-infection. Our results show that E. caproni infection in mice alters the peripheral lymphoid cell populations, which may be important to determine the course of the infection. In this sense, CD8(+) cells can be essential in relation to their role as a source of IFN-γ.
authors.affiliation: Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain. javier.sotillo@uv.es
authors.forename: Javier
authors.initials: J
authors.lastname: Sotillo
authors.forename: María
authors.initials: M
authors.lastname: Trelis
authors.forename: Bernard
authors.initials: B
authors.lastname: Fried
authors.forename: Antonio
authors.initials: A
authors.lastname: Marcilla
authors.forename: J Guillermo
authors.initials: JG
authors.lastname: Esteban
authors.forename: Rafael
authors.initials: R
authors.lastname: Toledo
mesh_terms: D000818:Animals; D018941:Antigens, CD19 / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D004195:Disease Models, Animal; D004449:Echinostoma / Q000276:immunology*; D004451:Echinostomiasis / Q000276:immunology*; D005434:Flow Cytometry; D007111:Immunity, Cellular; D016130:Immunophenotyping; D007371:Interferon-gamma / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013997:Time Factors
chemical_list: D018941:Antigens, CD19; D017252:CD3 Complex; D016827:CD8 Antigens; D007371:Interferon-gamma