title: [Mechanism of intravenous immunoglobulin therapy for severe hand-foot-mouth disease: a review].
abstract: Hand-foot-mouth disease (HFMD) is an acute infectious disease caused by various enteroviruses. Recently, large HFMD outbreaks caused by enterovirus type 71 (EV71) have been frequently reported in China, posing great threats on children's health. There is no specific antiviral therapy for severe HFMD, and patient management mainly depends on supportive and symptomatic treatment. Intravenous immunoglobulin (IVIG) is a pharmaceutical preparation of human IgG that is pooled from thousands of healthy blood donors, and contained neutralization antibodies against various enteroviruses, including EV71. IVIG therapy should be carefully administrated for severe HFMD considering its role on passive immunization against EV71 and immune regulation.
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiologv, Beijing 100071, China.
authors.forename: Ruiyuan
authors.initials: R
authors.lastname: Cao
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Han
authors.forename: Ede
authors.initials: E
authors.lastname: Qin
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Qin
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000276:immunology / Q000627:therapeutic use; D029821:Enterovirus A, Human / Q000276:immunology; D006232:Hand, Foot and Mouth Disease / Q000628:therapy* / Q000821:virology; D006801:Humans; D007116:Immunization, Passive; D016756:Immunoglobulins, Intravenous / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D016756:Immunoglobulins, Intravenous