title: Combination of narrow band imaging (NBI) and autofluorescence imaging (AFI) videobronchoscopy in endoscopic assessment of lung cancer extension.
abstract: Both narrow band imaging (NBI) and autofluorescence imaging (AFI) are new techniques for the assessment of lung cancer. The major aim of this study was to investigate whether the combination of these two techniques improve sensitivity and specificity in the assessment of lung cancer extension. The study prospectively evaluated 118 patients with suspected lung cancer. All of the patients were examined using EVIS LUCERA SPECTRUM videobronchoscopy system. The narrow band imaging preceded autofluorescence imaging examination. In every patient, at least 1 but no more than 4 biopsies were taken from places visualized as pathologic, surrounding primary tumor, and at least 1 biopsy from places that appeared visually normal. Sensitivity, specificity, positive, and negative predictive value for autofluorescence imaging in the assessment of tumor extension were 89.2, 77.8, 87, and 81%, respectively. Sensitivity, specificity, positive, and negative predictive value for narrow band imaging were 90.4, 82.4, 91.8, and 79.7%, respectively. Corresponding values for combination of techniques were 93.7, 86.9, 94.5, and 85.1%. Combination of techniques significantly improves sensitivity (P = 0.034) with borderline effect on specificity (P = 0.056) of autofluorescence imaging. There was no significant improvement for sensitivity and specificity of NBI alone. The combination of techniques shows significantly better sensitivity and specificity in the assessment of lung cancer extension when compared to white light videobronchoscopy alone, but improvement is not so convincing when compared to the each technique alone.
authors.affiliation: Department for Interventional Pulmonology, Institute for Pulmonary Diseases of Vojvodina, Clinic for Pulmonary Oncology, Faculty of Medicine, University of Novi Sad, Serbia, Institutski put 4, 21204 Sremska Kamenica, Serbia. bojanzaric@neobee.net
authors.forename: Bojan
authors.initials: B
authors.lastname: Zaric
authors.forename: Branislav
authors.initials: B
authors.lastname: Perin
authors.forename: Heinrich D
authors.initials: HD
authors.lastname: Becker
authors.forename: Felix Fj
authors.initials: FF
authors.lastname: Herth
authors.forename: Ralf
authors.initials: R
authors.lastname: Eberhardt
authors.forename: Svetlana
authors.initials: S
authors.lastname: Jovanovic
authors.forename: Tihomir
authors.initials: T
authors.lastname: Orlic
authors.forename: Milana
authors.initials: M
authors.lastname: Panjkovic
authors.forename: Biljana
authors.initials: B
authors.lastname: Zvezdin
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Jovelic
authors.forename: Milorad
authors.initials: M
authors.lastname: Bijelovic
authors.forename: Vladimir
authors.initials: V
authors.lastname: Jurisic
authors.forename: Milan
authors.initials: M
authors.lastname: Antonic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001999:Bronchoscopy / Q000379:methods*; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D061848:Optical Imaging / Q000379:methods; D012680:Sensitivity and Specificity; D014741:Video Recording / Q000379:methods