title: Extracorporeal artificial liver support in hypoxic liver injury.
abstract: The incidence of hypoxic liver injury, most commonly referred to as hypoxic hepatitis (HH), is up to 10% in critically ill patients. In the majority of cases, HH occurs as a consequence of haemodynamic impairment following cardiogenic or septic shock. A marked, dramatic increase in the aminotransferase levels in a setting of cardiocirculatory failure is the key characteristic of HH. HH may contribute to several complications such as hepatopulmonary syndrome and hypoglycaemia. The overall mortality after the onset of HH is approximately 50-60% within 1 month. We report a case of severe HH that was successfully bridged using the Molecular Adsorbent Recirculating System. In addition to the possible effects of extracorporeal liver support devices, the recognition of HH and therapy of the underlying disease that led to the occurrence of HH is of central importance.
authors.affiliation: Department of Internal Medicine 3, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Drolz
authors.forename: Reinhard
authors.initials: R
authors.lastname: Saxa
authors.forename: Thomas
authors.initials: T
authors.lastname: Scherzer
authors.forename: Valentin
authors.initials: V
authors.lastname: Fuhrmann
mesh_terms: D001219:Aspartate Aminotransferases / Q000097:blood; D006505:Hepatitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D000860:Hypoxia / Q000150:complications*; D006435:Renal Dialysis / Q000379:methods*; D015427:Reperfusion Injury / Q000150:complications*; D012772:Shock, Septic / Q000150:complications*; D016060:Sorption Detoxification / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D001219:Aspartate Aminotransferases