title: Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.
abstract: Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.
authors.affiliation: Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Zhang
authors.forename: Laura D
authors.initials: LD
authors.lastname: Wood
authors.forename: Robert A
authors.initials: RA
authors.lastname: Anders
authors.forename: Michael A
authors.initials: MA
authors.lastname: Choti
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Pawlik
authors.forename: Hubert D
authors.initials: HD
authors.lastname: Daniel
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kannangai
authors.forename: G Johan A
authors.initials: GJ
authors.lastname: Offerhaus
authors.forename: Victor E
authors.initials: VE
authors.lastname: Velculescu
authors.forename: Linfang
authors.initials: L
authors.lastname: Wang
authors.forename: Shibin
authors.initials: S
authors.lastname: Zhou
authors.forename: Bert
authors.initials: B
authors.lastname: Vogelstein
authors.forename: Ralph H
authors.initials: RH
authors.lastname: Hruban
authors.forename: Nick
authors.initials: N
authors.lastname: Papadopoulos
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Cai
authors.forename: Michael S
authors.initials: MS
authors.lastname: Torbenson
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Kinzler
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000821:virology*; D002843:Chromatin / Q000378:metabolism*; D005260:Female; D020868:Gene Silencing; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C512511:ARID2 protein, human; D002843:Chromatin; D014157:Transcription Factors