title: Adenylate kinase locus 1 polymorphism and feto-placental development.
abstract: OBJECTIVE
  Recently our group has found that the correlation between birth weight and placental weight - an index of a balanced feto-placental unit development - is influenced by genetic factors. Since adenylate kinase locus 1 (AK₁) is a polymorphic enzyme that plays an important role in the synthesis of nucleotides required for many metabolic functions, we have investigated the possible role of its genetic variability in the correlation between birth weight and placental weight.
  
  
  METHODS
  342 consecutive healthy newborn infants from the population of Rome (Italy) and 286 puerperae from another population from Central Italy were studied.
  
  
  RESULTS
  The correlation coefficient between birth weight and placental weight is much higher in infants with low activity AK₁2-1 phenotype than in those with high activity AK₁1 phenotype. The difference between AK₁ and AK₁2-1 is well marked only in newborns with a gestational age greater than 38 weeks and it is not influenced by sex, maternal age and maternal smoking. A similar pattern is observed with maternal AK₁ phenotype.
  
  
  CONCLUSIONS
  These results suggest that the difference in enzymatic activity between AK₁ phenotypes influencing the equilibrium among ATP, ADP, AMP and adenosine could have an important role in a balanced development of feto-placental unit.
authors.affiliation: Division of Biopathology of Human Population and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy. gloria@med.uniroma2.it
authors.forename: Gloria-Bottini
authors.initials: GB
authors.lastname: Fulvia
authors.forename: Pietroiusti
authors.initials: P
authors.lastname: Antonio
authors.forename: Neri
authors.initials: N
authors.lastname: Anna
authors.forename: Saccucci
authors.initials: S
authors.lastname: Patrizia
authors.forename: Amante
authors.initials: A
authors.lastname: Ada
authors.forename: Bottini
authors.initials: B
authors.lastname: Egidio
authors.forename: Magrini
authors.initials: M
authors.lastname: Andrea
mesh_terms: D000263:Adenylate Kinase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000483:Alleles; D001724:Birth Weight; D004592:Electrophoresis, Starch Gel; D005260:Female; D005312:Fetal Blood / Q000201:enzymology; D047109:Fetal Development; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D008297:Male; D009929:Organ Size; D010929:Placentation; D011110:Polymorphism, Genetic; D011247:Pregnancy
chemical_list: D000263:Adenylate Kinase; C110939:adenylate kinase 1