title: Computation of entropy and energetics profiles of a single-stranded viral DNA.
abstract: The bioinformatic aspects of computing entropy and energetic profiles associated with a viral single-stranded DNA (ssDNA) are addressed. The analyses envisaged thereof determine the structural (stem and loop) features, identify the CpG motifs and delineate the boundaries of coding DNA segments along a test viral (B19) ssDNA. The analytical modelling and computational efforts conform to Shannon entropy and thermodynamic kinetics of the test genome. Results are presented toward validation against available data. Pertinent details are reviewed in the context of their possible uses in rational vaccine designs.
authors.affiliation: Department of Computer and Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, Florida 33431, USA. neelakan@fau.edu
authors.forename: Perambur S
authors.initials: PS
authors.lastname: Neelakanta
authors.forename: Sharmistha
authors.initials: S
authors.lastname: Chatterjee
authors.forename: George A
authors.initials: GA
authors.lastname: Thengum-Pallil
mesh_terms: D004277:DNA, Single-Stranded; D004279:DNA, Viral / Q000235:genetics; D019277:Entropy; D016679:Genome, Viral; D006801:Humans
chemical_list: D004277:DNA, Single-Stranded; D004279:DNA, Viral