title: Kidney function and histological damage in autopsy subjects with myocardial infarction.
abstract: OBJECTIVE
  Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD). We previously reported renal parenchymal damage in autopsy subjects with stroke or abdominal aortic aneurysm. The aim of this study is to evaluate the relationship between renal histology and clinical characteristics of patients with myocardial infarction (MI).
  
  
  METHODS
  A total of 699 subjects were autopsied at the National Cerebral and Cardiovascular Center Hospital. We retrospectively evaluated all autopsy cases with MI (n = 123). Estimated glomerular filtration rate (eGFR) was calculated using the Japanese formula. Subjects were classified into four groups: 25 subjects with eGFR ≥ 60 mL/min/1.73 m(2) and no proteinuria (no CKD), 10 subjects with eGFR ≥ 60 and proteinuria (CKD1/2), 65 subjects with 60 > eGFR ≥ 30 (CKD3), and 23 subjects with eGFR < 30 (CKD4/5). Renal parenchymal damage was evaluated using a semi-quantitative histological score (score 0-3) for glomerulosclerosis, interstitial fibrosis, tubular atrophy, arteriolar hyalinosis, and arteriosclerosis of medium-sized artery (maximum score = 15).
  
  
  RESULTS
  The mean histological score was significantly higher in patients with CKD3 and CKD4/5 and was associated with age, hypertension, diabetes, kidney function, proteinuria, and other CVD.
  
  
  CONCLUSIONS
  In patients with MI, renal parenchymal damage and deteriorating kidney function are closely associated.
authors.affiliation: Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Niizuma
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakamura
authors.forename: Hatsue
authors.initials: H
authors.lastname: Ishibashi-Ueda
authors.forename: Fumiki
authors.initials: F
authors.lastname: Yoshihara
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Kawano
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D001707:Biopsy, Needle; D015331:Cohort Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007150:Immunohistochemistry; D007676:Kidney Failure, Chronic / Q000150:complications / Q000401:mortality* / Q000473:pathology*; D007677:Kidney Function Tests; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality* / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors