title: The epidemic of type 1 diabetes: what is it telling us?
abstract: OBJECTIVE
  Type 1 diabetes (T1D) is an autoimmune disorder which affects millions around the world. The incidence of T1D in children is increasing worldwide at a rate that cannot be explained by genetics alone. This review explores the recent research regarding possible causes of this epidemic.
  
  
  RESULTS
  Investigation into T1D epidemiology has recently focused on several hypotheses. These theories include the role of infections, early childhood diet, vitamin D exposure, environmental pollutants, increased height velocity, obesity, and insulin resistance in the risk for T1D. Over the past year, the evidence has strengthened for early childhood infections, dietary proteins, and insulin resistance as risk factors for T1D, but not for vitamin D exposure or environmental pollutants.
  
  
  CONCLUSIONS
  Investigation into the source of the current epidemic of T1D has shed light on several possible causes, but has not provided definitive answers, yet.
authors.affiliation: Department of Pediatrics, University of Colorado, Aurora, Colorado 80045, USA.
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Forlenza
authors.forename: Marian
authors.initials: M
authors.lastname: Rewers
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000276:immunology / Q000378:metabolism; D004032:Diet; D058872:Epidemics; D006801:Humans; D007333:Insulin Resistance / Q000276:immunology; D009765:Obesity / Q000378:metabolism; D015995:Prevalence; D012307:Risk Factors