title: Highly efficient one-pot access to functionalized arylboronic acids via noncryogenic bromine/magnesium exchanges.
abstract: A general and convenient protocol for the electrophilic borylation of aryl Grignard reagents prepared from arylbromides by direct insertion of magnesium in the presence of LiCl or by Mg/Br exchange with (i)PrMgCl·LiCl has been developed. Various aryl boronic acids were synthesized in a straightforward manner in excellent yields at 0 °C.
authors.affiliation: Laboratoire de Stéréochimie (UMR CNRS 7509), CNRS/Université de Strasbourg (ECPM), 25 Rue Becquerel, F-67087 Strasbourg, France.
authors.forename: Timo
authors.initials: T
authors.lastname: Leermann
authors.forename: Frédéric R
authors.initials: FR
authors.lastname: Leroux
authors.forename: Françoise
authors.initials: F
authors.lastname: Colobert
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D002245:Carbon Dioxide / Q000138:chemical synthesis / Q000737:chemistry; D056831:Coordination Complexes; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D017975:Ruthenium Compounds
chemical_list: D000588:Amines; D001897:Boronic Acids; D002245:Carbon Dioxide; D056831:Coordination Complexes; D006842:Hydrocarbons, Brominated; D009942:Organometallic Compounds; C547232:tris(2,2-bipyridine)-ruthenium(II); D017975:Ruthenium Compounds