title: Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine (-)-217A.
abstract: The enantiospecific and diastereocontrolled total synthesis of alkaloid (-)-217A is described that employs a stepwise [3+3] annelation strategy and a piperidine 2,3-cyclopropanation-ring opening reaction as the key steps.
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, UK.
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Mancey
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sandon
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Auvinet
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Butlin
authors.forename: Werngard
authors.initials: W
authors.lastname: Czechtizky
authors.forename: Joseph P A
authors.initials: JP
authors.lastname: Harrity
mesh_terms: D003521:Cyclopropanes / Q000737:chemistry; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry*; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D003521:Cyclopropanes; D010880:Piperidines; D011807:Quinolizines; C473050:alkaloid 217A; C030797:cyclopropane