title: Chromosomal aberrations in the bone marrow cells of mice induced by accelerated (12)C(6+) ions.
abstract: The whole bodies of 6-week-old male Kun-Ming mice were exposed to different doses of (12)C(6+) ions or X-rays. Chromosomal aberrations of the bone marrow (gaps, terminal deletions and breaks, fragments, inter-chromosomal fusions and sister-chromatid union) were scored in metaphase 9h after exposure, corresponding to cells exposed in the G(2)-phase of the first mitosis cycle. Dose-response relationships for the frequency of chromosomal aberrations were plotted both by linear and linear-quadratic equations. The data showed that there was a dose-related increase in the frequency of chromosomal aberrations in all treated groups compared to controls. Linear-quadratic equations were a good fit for both radiation types. The compound theory of dual radiation action was applied to decipher the bigger curvature (D(2)) of the dose-response curves of X-rays compared to those of (12)C(6+) ions. Different distributions of the five types of aberrations and different degrees of homogeneity were found between (12)C(6+) ion and X-ray irradiation and the possible underlying mechanism for these phenomena were analyzed according to the differences in the spatial energy deposition of both types of radiation.
authors.affiliation: Department of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Ma
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Wang
authors.forename: Xianhua
authors.initials: X
authors.lastname: Min
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Wu
authors.forename: Chao
authors.initials: C
authors.lastname: Sun
authors.forename: Bitao
authors.initials: B
authors.lastname: Hu
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000000981:diagnostic imaging; D002244:Carbon; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D020450:Heavy Ions; D018499:Linear Energy Transfer; D008297:Male; D008677:Metaphase; D051379:Mice; D014463:Ultrasonography; D014916:Whole-Body Irradiation; D014965:X-Rays
chemical_list: D002244:Carbon