title: Protection by vanadium, a contemporary treatment approach to both diabetes and focal cerebral ischemia in rats.
abstract: There is now substantial epidemiological evidence that diabetes is a risk factor for cerebrovascular disease. The protection by vanadium from focal cerebral ischemia in diabetic rats was studied in this paper. Rats with streptozotocin-induced diabetes were subjected to middle cerebral artery occlusion followed by 4 weeks of administration of 0.6 mg/ml sodium orthovanadate in drinking water. Vanadium significantly improved the outcome in diabetic rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. Vanadium reduces brain damage in streptozotocin-induced diabetic rats by imitating action of insulin.
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Zhenquan
authors.initials: Z
authors.lastname: Liu
authors.forename: Pengtao
authors.initials: P
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Huiling
authors.initials: H
authors.lastname: Tang
authors.forename: Jianyou
authors.initials: J
authors.lastname: Guo
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000401:mortality / Q000517:prevention & control*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D007328:Insulin / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D015996:Survival Rate; D014638:Vanadates / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D018696:Neuroprotective Agents; D014638:Vanadates; D007770:L-Lactate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione