title: Physiopathological mechanism of sarcopenia.
abstract: The etiology of sarcopenia is multifactorial but still poorly understood, and the sequelae of this phenomenon represent a major public health issue. Age-related loss of muscle mass can be counteracted by adequate metabolic interventions including nutritional intake and exercise training. Other strategies including changes in daily protein pattern, the speed of protein digestion, or specific amino acid supplementation may be beneficial to improve short-term muscle anabolic response in elderly people. A multimodal approach combining nutrition, exercise, hormones, and specific anabolic drugs may be an innovative treatment for limiting the development of sarcopenia with aging.
authors.affiliation: INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, F-63009, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Walrand
authors.forename: Christelle
authors.initials: C
authors.lastname: Guillet
authors.forename: Jérome
authors.initials: J
authors.lastname: Salles
authors.forename: Noël
authors.initials: N
authors.lastname: Cano
authors.forename: Yves
authors.initials: Y
authors.lastname: Boirie
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001823:Body Composition; D004044:Dietary Proteins / Q000378:metabolism*; D015444:Exercise; D005260:Female; D006728:Hormones / Q000502:physiology*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000150:complications; D055948:Sarcopenia / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy
chemical_list: D004044:Dietary Proteins; D006728:Hormones