title: Unresponsiveness to a kidney graft after a fully matched allogenic bone marrow transplantation combined with low-dose tacrolimus therapy: a case report.
abstract: We present the case of a patient with past medical history of acute mieloblastic leukemia treated with a related, fully match alogenic bone marrow transplantation (BMT). He presented after BMT treatment graft versus host disease (GVHD) and thrombotic thrombocytopenic purpura. He also developed end-stage renal disease that required renal replacement therapy. A preemptive kidney transplant was performed. The haematopoiesis were in complete chimera and the patient developed tolerance to the kidney graft, requiring only minimal immunossupression because of his GVHD.
authors.affiliation: Transplantation Unit, Clínica Dávila, Santiago, Chile.
authors.forename: S
authors.initials: S
authors.lastname: Álvarez
authors.forename: A
authors.initials: A
authors.lastname: Boltansky
authors.forename: J
authors.initials: J
authors.lastname: Alfaro
authors.forename: L
authors.initials: L
authors.lastname: Sepúlveda
authors.forename: M
authors.initials: M
authors.lastname: Ursu
authors.forename: G
authors.initials: G
authors.lastname: Innocenti
authors.forename: D
authors.initials: D
authors.lastname: Carvajal
authors.forename: G
authors.initials: G
authors.lastname: Villamizar
authors.forename: M
authors.initials: M
authors.lastname: Hurtado
authors.forename: A
authors.initials: A
authors.lastname: Vukusich
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D008297:Male; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology; D018183:Transplantation Chimera; D023001:Transplantation Tolerance; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents