title: Viridaphin A₁ glucoside, a green pigment possessing cytotoxic and antibacterial activity from the aphid Megoura crassicauda.
abstract: A green pigment, viridaphin A₁ glucoside (1), was isolated from the green aphid Megoura crassicauda. One- and two-dimensional NMR spectrometric analyses of 1 and its aglycone established the structure as an octacyclic compound. Viridaphin A₁ glucoside exhibited cytotoxicity against HL-60 human tumor cells with an IC₅₀ of 23 μM and antibacterial activity against Bacillus subtilis NBRC 3134 with a minimum inhibitory concentration of 10.0 μg/mL. These results suggested that aphid pigments may protect aphids from invasive species, including viruses and bacteria.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan. horikawa@ph.bunri-u.ac.jp
authors.forename: Mitsuyo
authors.initials: M
authors.lastname: Horikawa
authors.forename: To-Sho
authors.initials: TS
authors.lastname: Hoshiyama
authors.forename: Masako
authors.initials: M
authors.lastname: Matsuzawa
authors.forename: Takanori
authors.initials: T
authors.lastname: Shugyo
authors.forename: Masami
authors.initials: M
authors.lastname: Tanaka
authors.forename: Shinya
authors.initials: S
authors.lastname: Suzuki
authors.forename: Masao
authors.initials: M
authors.lastname: Sato
authors.forename: Takuya
authors.initials: T
authors.lastname: Ito
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kaku
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishii
authors.forename: Makoto
authors.initials: M
authors.lastname: Inai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Takahashi
authors.forename: Tetsuto
authors.initials: T
authors.lastname: Tsunoda
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001042:Aphids / Q000737:chemistry* / Q000502:physiology; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007564:Japan; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D005960:Glucosides; D010860:Pigments, Biological; C561984:viridaphin A(1) glucoside