title: Clotting profile in cattle showing chronic enzootic haematuria (CEH) and bladder neoplasms.
abstract: Primary haemostasis (bleeding and blood clotting time), activated partial thromboplastin time (APTT), prothrombin time (PT), antithrombin III (ATIII), protein C, protein S, fibrinogen and D-dimer were determined in 13 cattle affected by chronic enzootic haematuria (CEH) and bladder neoplasms and 10 healthy cattle (control group). Increases in antithrombin III and protein S activities (P<0.01) and protein C and fibrinogen plasma levels (P<0.05) were observed in sick animals, while activated partial thromboplastin time, prothrombin time, and D-dimer did not show significant differences when compared to healthy animals. The clotting profile observed does not seem responsible for the chronic bleeding typical of CEH. The observed modification of some coagulation markers may derive from multiple interactions among cancer, inflammation and viral infection status typical of this syndrome.
authors.affiliation: Department of Clinical Veterinary Science, Internal Medicine Section University Federico II, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Di Loria
authors.forename: D
authors.initials: D
authors.lastname: Piantedosi
authors.forename: L
authors.initials: L
authors.lastname: Cortese
authors.forename: S
authors.initials: S
authors.lastname: Roperto
authors.forename: C
authors.initials: C
authors.lastname: Urraro
authors.forename: O
authors.initials: O
authors.lastname: Paciello
authors.forename: J
authors.initials: J
authors.lastname: Guccione
authors.forename: D
authors.initials: D
authors.lastname: Britti
authors.forename: P
authors.initials: P
authors.lastname: Ciaramella
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood* / Q000473:pathology; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006417:Hematuria / Q000097:blood / Q000662:veterinary*; D006487:Hemostasis; D010314:Partial Thromboplastin Time / Q000662:veterinary; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D011517:Prothrombin Time / Q000662:veterinary; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000473:pathology / Q000662:veterinary*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D011486:Protein C; D017293:Protein S; C036309:fibrin fragment D; D000990:Antithrombin III; D005340:Fibrinogen