title: Synthesis of quinoxaline 1,4-di-N-oxide analogues and crystal structure of 2-carbomethoxy-3-hydroxyquinoxaline-di-N-oxide.
abstract: A series of quinoxaline 1,4-di-N-oxide analogues were prepared from benzofurazan N-oxide derivatives and β-diketone ester compounds by the improved Beirut reaction. The structures of the target products were characterized by NMR, MS, IR and elemental analysis measurements, and that of 2-carbomethoxy-3-hydroxyquinoxaline- di-N-oxide was further confirmed by single-crystal X-ray diffraction. Its crystal structure belongs to the monoclinic system, space group C2/c with a = 14.4320 (12) Å, b = 10.7514 (9) Å, c = 13.2728 (11) Å, V = 1958.5 (3) Å 3, Z = 8. The X-ray crystallographic analysis reveals that quinoxaline 1,4-di-N-oxide displays acyloin-endiol tautomerism.
authors.affiliation: College of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 200235, China.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Xu
authors.forename: Fanhong
authors.initials: F
authors.lastname: Wu
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Yao
authors.forename: Minmin
authors.initials: M
authors.lastname: Zhang
authors.forename: Sheng
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis / Q000138:chemical synthesis*; D001688:Biological Products / Q000032:analysis / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D004952:Esters / Q000737:chemistry; D007536:Isomerism; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D011810:Quinoxalines / Q000032:analysis / Q000138:chemical synthesis*
chemical_list: D000890:Anti-Infective Agents; D001688:Biological Products; D004952:Esters; D007659:Ketones; D011810:Quinoxalines