title: [Expression of ID3 protein in prostate cancer and its clinicopathological significance].
abstract: OBJECTIVE
  To study the expression of the ID3 protein in prostate cancer and its clinicopathological significance.
  
  
  METHODS
  We detected the expression of the ID3 protein in PC-3M cells by indirect immunofluorescence, and that in 29 prostate cancer and 15 prostate hyperplasia specimens by immunohistochemistry. Then we analyzed the correlation between the expression level of ID3 and the clinicopathological parameters.
  
  
  RESULTS
  The ID3 protein was expressed predominantly in the nucleus of PC-3M cells. Its expression rate was 82.7% (24/29) in the prostate cancer specimens, significantly higher than 6.6% (1/15) in prostate hyperplasia (P < 0.05), and was positively correlated with the Gleason score of prostate cancer (P < 0.05).
  
  
  CONCLUSIONS
  The ID3 protein is expressed in prostate cancer, and is elevated with the increase of Gleason score.
authors.affiliation: PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Li
authors.forename: Hong-lin
authors.initials: HL
authors.lastname: Yin
authors.forename: Hang-bo
authors.initials: HB
authors.lastname: Zhou
authors.forename: Fang-fang
authors.initials: FF
authors.lastname: Chen
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
authors.forename: Heng-hui
authors.initials: HH
authors.lastname: Ma
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015200:Fluoroimmunoassay; D006801:Humans; D007150:Immunohistochemistry; D051796:Inhibitor of Differentiation Proteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D051796:Inhibitor of Differentiation Proteins; D009363:Neoplasm Proteins; C075640:ID3 protein, human