title: Can the rat be used as a valid model of human esophageal adenocarcinoma?
abstract: Animal models of Barrett's metaplasia and esophageal adenocarcinoma are important to further characterize the disease and test potential therapies. This paper reviews the development of the surgical model of esophageal adenocarcinoma in the rat and considers whether this model provides a biologically accurate representation of Barrett's esophagus and esophageal adenocarcinoma in humans.
authors.affiliation: Department of Upper GI Surgery, Norfolk and Norwich University Hospital, Norwich, UK. andrewhindmarsh@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Hindmarsh
authors.forename: N
authors.initials: N
authors.lastname: Belshaw
authors.forename: S
authors.initials: S
authors.lastname: Mehta
authors.forename: I T
authors.initials: IT
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Rhodes
mesh_terms: D000230:Adenocarcinoma; D000818:Animals; D001471:Barrett Esophagus; D018899:CpG Islands / Q000502:physiology; D004195:Disease Models, Animal; D004938:Esophageal Neoplasms; D004947:Esophagus / Q000601:surgery; D005764:Gastroesophageal Reflux; D006801:Humans; D008745:Methylation; D051381:Rats