title: Atypical fibrosarcomas derived from cutaneous ganglion cell-like cells in 2 domestic Djungarian hamsters (Phodopus sungorus).
abstract: Androgen-dependent atypical fibromas are benign tumors derived from ganglion-cell-like cells that are particular to Djungarian hamsters (Phodopus sungorus). Masses excised from 2 hamsters were composed of pleomorphic ganglion cell-like cells supported by small to moderate amounts of collagenous matrix. Intracytoplasmic fibrils were present in silver-stained sections, and immunohistochemistry showed that the cells expressed vimentin, androgen receptor, and, in one case, estrogen receptor α. In contrast to previously reported atypical fibromas, these tumors had features of anaplasia and were locally invasive. We diagnosed the tumors as atypical fibrosarcomas and consider them an unusual malignant counterpart of atypical fibroma.
authors.affiliation: Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA. kondoh@ufl.edu
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kondo
authors.forename: Mamoru
authors.initials: M
authors.lastname: Onuma
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shibuya
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Sato
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Abbott
mesh_terms: D000818:Animals; D006224:Cricetinae; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D006652:Histological Techniques / Q000662:veterinary; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D017111:Phodopus; D012376:Rodent Diseases / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*