title: Effects of sensitization on the detection of an instrumental contingency.
abstract: While prior exposure to drugs of abuse permanently changes many behaviors, the underlying psychological mechanisms are relatively obscure. Here, the effects of sensitization on the detection of an action-outcome relationship were assessed, using a particularly stringent contingency degradation procedure. Rats were trained to leverpress until the probability of reinforcement for a response on one lever, or alternative reinforcement for a response on a second lever was reduced to 0.05 per second. Sensitization was then carried out (1mg/kg d-amphetamine/day for 7 days). Then, one reinforcer was also made available for a lack of response on either lever (p=0.05/s), maintaining its contiguity with the original response but eliminating its contingent relationship. Sensitized animals were more active, particularly early in the contingency degradation phase, but reduced responding directed at the degraded action-outcome contingency at a similar rate as controls. However, controls also reduced responding directed at the nondegraded contingency until very late in training, while sensitized animals maintained nondegraded responding at baseline levels. It was suggested that the relatively specific response shown by sensitized animals may reflect either improved action-outcome utilization or discrimination of relevant task features.
authors.affiliation: Department of Psychology, University of York, Heslington, York YO10 5DD, UK. g.phillips@psych.york.ac.uk
authors.forename: Gavin D
authors.initials: GD
authors.lastname: Phillips
authors.forename: Anthony
authors.initials: A
authors.lastname: Vugler
mesh_terms: D000661:Amphetamine / Q000008:administration & dosage*; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012054:Reinforcement, Psychology; D012646:Self Administration
chemical_list: D000661:Amphetamine