title: Antimicrobial and hemolytic activities of copolymers with cationic and hydrophobic groups: a comparison of block and random copolymers.
abstract: Random and diblock copolymers of 2-(N,N-dimethylamino)ethyl methacrylate and butyl methacrylate are prepared by ATRP. As mimics of cationic antimicrobial peptides, the random and diblock copolymers show similar antimicrobial activities. In contrast, the diblock copolymers have much lower hemolytic activities than the random copolymers. The cell selectivity (HC(50)/MIC, where HC(50) is the concentration to lyse 50% of human red blood cells and MIC is the minimum concentration to inhibit bacterial growth) of the diblock copolymers are 150 to 27,500 times higher than that of random copolymers with similar compositions.
authors.affiliation: Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin, China.
authors.forename: Yanqiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Junjuan
authors.initials: J
authors.lastname: Xu
authors.forename: Yueheng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Husheng
authors.initials: H
authors.lastname: Yan
authors.forename: Keliang
authors.initials: K
authors.lastname: Liu
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology; D002412:Cations / Q000737:chemistry; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D018716:Molecular Mimicry; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D002412:Cations; D008689:Methacrylates; D011108:Polymers