title: Water-jet-aided transurethral dissection of urothelial carcinoma: a prospective clinical study.
abstract: OBJECTIVE
  The application of a water-jet dissector for mucosal elevation was shown to improve resection of lesions of the gastrointestinal tract. We present the first prospective clinical trial on the application of a combined water-jet dissector and needle-knife (HybridKnife) in transurethral dissection (TUD) of urothelial carcinoma of the bladder (UCB).
  
  
  METHODS
  Thirty separate urothelial tumors of the bladder in 17 unselected patients were elevated and dissected with the HybridKnife. The goal was to determine the safety, effectiveness of resection, and overall applicability of the HybridKnife.
  
  
  RESULTS
  No perforation or other complication was seen. All tumors could be dissected from the bladder wall en bloc. TUD of UCB by using the HybridKnife is technically feasible and safe in the resection of papillary and solid tumors.
  
  
  CONCLUSIONS
  The application of the HybridKnife in TUD of UCB appears to be a feasibly safe and applicable for en-bloc dissection technique potentially following principles of oncologic surgery in transurethral removal of UCB. It seems to facilitate histopathologic assessment. A possibly improved oncologic outcome has to be addressed in further studies.
authors.affiliation: Department of Urology, University of Regensburg , Caritas St. Josef Medical Center, Regensburg, Germany.
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Fritsche
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Otto
authors.forename: Fabian
authors.initials: F
authors.lastname: Eder
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Hofstädter
authors.forename: Stefan
authors.initials: S
authors.lastname: Denzinger
authors.forename: Christian G
authors.initials: CG
authors.lastname: Chaussy
authors.forename: Christian
authors.initials: C
authors.lastname: Stief
authors.forename: Wolf F
authors.initials: WF
authors.lastname: Wieland
authors.forename: Maximilian
authors.initials: M
authors.lastname: Burger
mesh_terms: D000818:Animals; D004210:Dissection / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D011446:Prospective Studies; D034421:Sus scrofa; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*; D019459:Urothelium / Q000473:pathology / Q000601:surgery*; D014867:Water
chemical_list: D014867:Water