title: Synthesis of a 4H-anthra[1,2-b]pyran derivative and its antimicrobial activity.
abstract: The five-step synthesis of the new 4H-anthra[1,2-b]pyran derivative 1 is reported. The key steps in this approach included a Marschalk alkylation of 1,4-dihydroxyanthraquinone followed by a Baker-Venkataraman reaction and then an acid-catalyzed cyclization of ring A to form the 4H-anthra[1,2-b]pyran system. Two compounds, the 4H-anthra[1,2-b]pyran 1 and the anthraquinone derivative 6 were evaluated for antimicrobial activity and showed moderate antialgal, antifungal, and antibacterial activities.
authors.affiliation: Department of Chemistry, Universität Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany. Hidayat110@gmail.com
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Shahid
authors.initials: S
authors.lastname: Aziz
authors.forename: Barbara
authors.initials: B
authors.lastname: Schulz
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D011714:Pyrans