title: A case of a giant glucagonoma with parathyroid hormone-related peptide secretion showing an inconsistent postsurgical endocrine status.
abstract: A 53-year-old woman was admitted because of a giant pancreatic tumor. Hypercalcemia and a high serum parathyroid hormone-related peptide (PTHrP) level were observed. A hypoglycemic attack occurred during pancreatectomy, and the surgical specimen revealed a PTHrP-secreting glucagonoma. Liver metastases developed 1 and 5.5 years later, and bone metastases appeared 6 years after surgery. Her serum PTHrP concentrations remained normal after surgery, despite re-elevation of the serum glucagon concentration after recurrence. The clinical course of this case illustrates the process of development of neuroendocrine tumors secreting two or more hormones.
authors.affiliation: The Second Department of Internal Medicine, Wakayama Medical University, Japan. spk449q9@voice.ocn.ne.jp
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Shirai
authors.forename: Izumi
authors.initials: I
authors.lastname: Inoue
authors.forename: Jun
authors.initials: J
authors.lastname: Kato
authors.forename: Hiroki
authors.initials: H
authors.lastname: Maeda
authors.forename: Kosaku
authors.initials: K
authors.lastname: Moribata
authors.forename: Naoki
authors.initials: N
authors.lastname: Shingaki
authors.forename: Kazuki
authors.initials: K
authors.lastname: Ueda
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Deguchi
authors.forename: Takao
authors.initials: T
authors.lastname: Maekita
authors.forename: Mikitaka
authors.initials: M
authors.lastname: Iguchi
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Yanaoka
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tamai
authors.forename: Masashi
authors.initials: M
authors.lastname: Oka
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawai
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yamaue
authors.forename: Hironao
authors.initials: H
authors.lastname: Yasuoka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Iso-O
authors.forename: Masao
authors.initials: M
authors.lastname: Ichinose
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000556:secondary; D005260:Female; D005934:Glucagon / Q000378:metabolism; D005935:Glucagonoma / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000556:secondary; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery*; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism*; D011184:Postoperative Period
chemical_list: D044162:Parathyroid Hormone-Related Protein; D005934:Glucagon