title: Comparative study on antioxidant capacity of flavonoids and their inhibitory effects on oleic acid-induced hepatic steatosis in vitro.
abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and its incidence is rising worldwide. We compared the antioxidant capacity of seventeen flavonoids with their inhibitory effects on oleic acid-induced triglyceride (TG) over-accumulation in HepG2 cells. The results showed significant correlations (P < 0.01) between the inhibition of intracellular TG levels and the suppression effects on reactive oxygen species. Nevertheless, the radical-reducing activities of flavonoids assessed by chemical assays (cyclic voltammetry and Folin-Ciocalteu reagent assay) were poorly correlated with their intracellular TG inhibitory effects. The relationships between structural properties of flavonoids and their inhibitory effects on TG over-accumulation were discussed.
authors.affiliation: College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, People's Republic of China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.forename: Liyang
authors.initials: L
authors.lastname: Xie
authors.forename: Gang
authors.initials: G
authors.lastname: Jia
authors.forename: Shengbao
authors.initials: S
authors.lastname: Cai
authors.forename: Baoping
authors.initials: B
authors.lastname: Ji
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Aili
authors.initials: A
authors.lastname: Wang
authors.forename: Le
authors.initials: L
authors.lastname: Chu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Fengyi
authors.initials: F
authors.lastname: Gao
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002460:Cell Line; D005234:Fatty Liver / Q000378:metabolism / Q000517:prevention & control*; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D019301:Oleic Acid / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D017382:Reactive Oxygen Species; D014280:Triglycerides; D019301:Oleic Acid