title: True and sham acupuncture produced similar frequency of ovulation and improved LH to FSH ratios in women with polycystic ovary syndrome.
abstract: BACKGROUND
  Acupuncture may represent a nonpharmaceutical treatment for women with polycystic ovary syndrome (PCOS), based on four studies.
  
  
  OBJECTIVE
  The objective of the study was to determine whether true, as compared with sham, acupuncture normalizes pituitary gonadotropin hormones and increases ovulatory frequency in women with PCOS.
  
  
  METHODS
  This was a randomized, double-blind, sham-controlled clinical trial (5 month protocol).
  
  
  METHODS
  The study was conducted in central Virginia.
  
  
  METHODS
  Eighty-four reproductive-aged women completed the intervention. Eligibility required a PCOS diagnosis and no hormonal intervention 60 d before enrollment.
  
  
  METHODS
  Intervention included 12 sessions of true or sham acupuncture (Park sham device) for 8 wk.
  
  
  METHODS
  Serum LH and FSH at baseline, after intervention, and 3 months later were measured. Ovulation was measured with weekly urine or blood samples.
  
  
  RESULTS
  Both arms demonstrated a similar mean ovulation rate over the 5 months (0.37/month among n = 40 true acupuncture and 0.40/month among n = 44 sham participants, P = 0.6), similar LH to FSH ratio improvement (-0.5 and -0.8 true and sham, respectively, P < 0.04 after intervention vs. baseline) and a similar decline in LH over the 5-month protocol (P < 0.05). Neither arm experienced a change in FSH. There were seven pregnancies (no difference by intervention, P = 0.7). Lower fasting insulin and free testosterone were highly correlated with a higher ovulation rate within the true acupuncture group only (P = 0.03), controlling for prestudy menstrual frequency and body mass index.
  
  
  CONCLUSIONS
  We were unable to discern a difference between the true and sham acupuncture protocols for these women with PCOS, and both groups had a similar improvement in their LH/FSH ratio.
authors.affiliation: Department of Obstetrics/Gynecology, University of Virginia, Charlottesville, Virginia 22908, USA. lpastore@virginia.edu
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Pastore
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Williams
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Jenkins
authors.forename: James T
authors.initials: JT
authors.lastname: Patrie
mesh_terms: D015670:Acupuncture Therapy; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D004311:Double-Blind Method; D004522:Educational Status; D005006:Ethnicity; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006728:Hormones / Q000097:blood; D006801:Humans; D008137:Longitudinal Studies; D007986:Luteinizing Hormone / Q000097:blood*; D008598:Menstruation / Q000502:physiology; D010060:Ovulation / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D006728:Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone