title: Post-translational modification of the androgen receptor.
abstract: Regulation of the androgen receptor (AR) by its cognate ligand is well established, but how post-translational modification modulates AR activity is only emerging. The AR is subject to modification by phosphorylation, acetylation, methylation, SUMOylation, and ubiquitination. As several of the enzymes that modify the AR are altered in prostate cancer, defining the context and physiological effects of these modifications could provide insight into mechanisms that underpin human disease. Here, we review how post-translational modification contributes to AR function as a transcription factor with particular emphasis on phosphorylation and dephosphorylation mechanisms.
authors.affiliation: Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gioeli
authors.forename: Bryce M
authors.initials: BM
authors.lastname: Paschal
mesh_terms: D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms; D011499:Protein Processing, Post-Translational; D011944:Receptors, Androgen / Q000378:metabolism*
chemical_list: D011944:Receptors, Androgen