title: Adiponectin gene and risk of colorectal cancer.
abstract: BACKGROUND
  Genes of the adiponectin pathway are interesting candidates for colorectal cancer risk based on the potential association between colorectal cancer and obesity. However, variants of the adiponectin gene (ADIPOQ) have been demonstrated to be inconsistently associated with risk of colorectal cancer.
  
  
  METHODS
  The current study attempted to evaluate these findings by examining several single nucleotide polymorphisms (SNPs) that were previously genotyped as part of a genome-wide association study in the ADIPOQ gene. Genotyping was also performed for a previously reported risk variant, rs266729, in 1062 individuals with a diagnosis of colorectal cancer and 1062 controls matched on age, gender and ethnicity (Jewish or not Jewish) as part of a population-based case-control study in Israel.
  
  
  RESULTS
  No evidence was found for an association between ADIPOQ and risk of colorectal cancer. The single nucleotide variant previously associated with decreased risk of colorectal cancer, rs266729, revealed an adjusted odds ratio of 1.04; 95% confidence interval, 0.88-1.23.
  
  
  CONCLUSIONS
  The SNP, rs266729, was not strongly associated with colorectal cancer in patients of Ashkenazi Jewish descent or other ethnic groups in Israel.
authors.affiliation: Department of Human Genetics, University of Michigan School of Medicine, 1524 BSRB, 109 Zina Pitcher, Ann Arbor, MI, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Gornick
authors.forename: G
authors.initials: G
authors.lastname: Rennert
authors.forename: V
authors.initials: V
authors.lastname: Moreno
authors.forename: S B
authors.initials: SB
authors.lastname: Gruber
mesh_terms: D052242:Adiponectin / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007585:Jews / Q000235:genetics* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin