title: Preparation and characterization of temperature-responsive magnetic composite particles for multi-modal cancer therapy.
abstract: The temperature-responsive magnetic composite particles were synthesized by emulsion-free polymerization of N-isopropylacrylamide (NIPAAm) and acrylamide (Am) in the presence of oleic acid-modified Fe(3)O(4) nanoparticles. The magnetic properties and heat generation ability of the composite particles were characterized. Furthermore, temperature and alternating magnetic field (AMF) triggered drug release behaviors of vitamin B(12)-loaded composite particles were also examined. It was found that composite particles enabled drug release to be controlled through temperature changes in the neighborhood of lower critical solution temperature. Continuous application of AMF resulted in an accelerated release of the loaded drug. On the other hand, intermittent AMF application to the composite particles resulted in an "on-off", stepwise release pattern. Longer release duration and larger overall release could be achieved by intermittent application of AMF as compared to continuous magnetic field. Such composite particles may be used for magnetic drug targeting followed by simultaneous hyperthermia and drug release.
authors.affiliation: School of Materials Science and Engineering, Tongji University, Shanghai, 200092, China. aihyao@126.com
authors.forename: Aihua
authors.initials: A
authors.lastname: Yao
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.forename: Fanrong
authors.initials: F
authors.lastname: Ai
authors.forename: Deping
authors.initials: D
authors.lastname: Wang
authors.forename: Wenhai
authors.initials: W
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D006801:Humans; D015603:Keratinocytes; D019344:Lactic Acid / Q000737:chemistry; D008280:Magnetics; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012867:Skin; D013696:Temperature; D013997:Time Factors; D023822:Tissue Engineering
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D011091:Polyesters; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C016240:polycaprolactone; D011100:Polyglycolic Acid; D019344:Lactic Acid