title: Pharmacogenetic testing to predict antipsychotic-induced weight gain: a systematic review.
abstract: Weight gain is an important side effect of antipsychotic drugs. Since the high interindividual difference in weight gain suggests that genetic factors play a role in this weight gain, studies have tried to identify these factors. Most of these studies were carried out in the past few years and focussed largely on receptor polymorphisms, although some tried to explain the variation in weight gain by differences in pharmacokinetics. Unfortunately, the results of these association studies are often conflicting, which makes it hard to apply this genetic knowledge in daily clinical practice. This article summarizes the findings of these association studies and focuses on differences in study methodology in an attempt to explain why study results could have been conflicting. Furthermore, the feasibility of genetic testing in today's clinical practice is discussed, using a model that consists of four components; analytical validity, clinical validity, clinical utility and ethical, legal and social issues.
authors.affiliation: Department of Pharmacoepidemiology & Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
authors.forename: Arne J
authors.initials: AJ
authors.lastname: Risselada
authors.forename: Hans
authors.initials: H
authors.lastname: Mulder
authors.forename: Eibert R
authors.initials: ER
authors.lastname: Heerdink
authors.forename: Toine C G
authors.initials: TC
authors.lastname: Egberts
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D010597:Pharmacogenetics; D011237:Predictive Value of Tests; D011618:Psychotic Disorders / Q000150:complications / Q000378:metabolism; D015203:Reproducibility of Results; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents