title: Tissue distribution of hesperetin in rats after a dietary intake.
abstract: Hesperetin, the aglycone of hesperidin present in citrus fruits, possesses various biological activities. We assessed the tissue distribution of hesperetin in rats fed with a 0.2% hesperetin diet for 4 weeks. Its highest concentration was found in the liver, and the second highest was in the aorta. The aorta is assumed to be one of the main target tissues of hesperetin for exerting its functions.
authors.affiliation: Institute of Health Sciences, Ezaki Glico Co., Ltd., Nishiyodogawa-ku, Osaka, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Takumi
authors.forename: Rie
authors.initials: R
authors.lastname: Mukai
authors.forename: Sawako
authors.initials: S
authors.lastname: Ishiduka
authors.forename: Takashi
authors.initials: T
authors.lastname: Kometani
authors.forename: Junji
authors.initials: J
authors.lastname: Terao
mesh_terms: D000818:Animals; D001011:Aorta / Q000737:chemistry*; D001682:Biological Availability; D002199:Capillary Permeability / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000178:diet therapy / Q000503:physiopathology; D002851:Chromatography, High Pressure Liquid; D002957:Citrus / Q000737:chemistry*; D004032:Diet; D006569:Hesperidin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D008099:Liver / Q000737:chemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D006569:Hesperidin; C013015:hesperetin