title: Microbial transformation of deoxyandrographolide by Alternaria alternata AS 3.4578.
abstract: Biotransformation of deoxyandrographolide (1) by Alternaria alternata AS 3.4578 gave five derivatives identified by spectral methods including 2D NMR as the known dehydroandrographolide (2) and 9beta-hydroxy-dehydroandrographolide (3) and the new compounds 9beta-hydroxy-deoxyandrographolide (4), 3alpha,17,19-trihydroxy-8,13-ent-labdadien-15,16-olide (5) and 3-oxo-9beta-hydroxy-deoxyandrographolide (6).
authors.affiliation: Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing 100029, China.
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Xin
authors.forename: Sha
authors.initials: S
authors.lastname: Deng
authors.forename: Bao-Jing
authors.initials: BJ
authors.lastname: Zhang
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Tian
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Ma
authors.forename: Lei
authors.initials: L
authors.lastname: An
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Shu
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Yao
authors.forename: Xun
authors.initials: X
authors.lastname: Cui
mesh_terms: D000528:Alternaria / Q000378:metabolism*; D035685:Andrographis / Q000737:chemistry; D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: C114791:14-deoxyandrographolide; D004224:Diterpenes