title: Morphological studies of the murine heart based on probabilistic and statistical atlases.
abstract: This study directly compares morphological features of the mouse heart in its end-relaxed state based on constructed morphometric maps and atlases using principal component analysis in C57BL/6J (n=8) and DBA (n=5) mice. In probabilistic atlases, a gradient probability exists for both strains in longitudinal locations from base to apex. Based on the statistical atlases, differences in size (49.8%), apical direction (15.6%), basal ventricular blood pool size (13.2%), and papillary muscle shape and position (17.2%) account for the most significant modes of shape variability for the left ventricle of the C57BL/6J mice. For DBA mice, differences in left ventricular size and direction (67.4%), basal size (15.7%), and position of papillary muscles (16.8%) account for significant variability.
authors.affiliation: Department of Mechanical and Manufacturing Engineering, School of Engineering, University of Cyprus, Nicosia, Cyprus.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Perperidis
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Bucholz
authors.forename: G Allan
authors.initials: GA
authors.lastname: Johnson
authors.forename: Christakis
authors.initials: C
authors.lastname: Constantinides
mesh_terms: D000465:Algorithms; D000818:Animals; D003287:Contrast Media; D003627:Data Interpretation, Statistical; D019786:Gadolinium DTPA; D006321:Heart / Q000033:anatomy & histology*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA