title: [Cancellation of IVF-ET cycles: poor prognosis, poor responder, or variability of the response to controlled ovarian hyperstimulation? An analysis of 142 cancellations].
abstract: BACKGROUND
  This retrospective study aimed at analyzing IVF-ET management and outcome after cancellation of a first cycle for poor response.
  
  
  METHODS
  One hundred and forty-two infertile patients were included in this observational study. After an overall analysis on the outcome of the second IVF-ET attempt, a sub-analysis was performed according to the presence or the absence of poor prognostic criteria defined as mentioned: patient age superior to 38 years old, antral follicle count (3-9 mm in diameter) inferior to 10 on cycle day 3 and day 3 serum AMH and FSH levels less than 1 ng/mL and more than 10 IU/mL, respectively. Main outcome measures were the cancellation rates, pregnancy and live birth rates.
  
  
  RESULTS
  When a controlled ovarian stimulation was performed, patients with poor prognosis had higher cancellation rates (37.8% vs. 13.3%, P<0.004) and lower pregnancy and live birth rates (22.2% vs. 35.0%, P<0.05 and 11.1% vs. 26.1%, P<0.05, respectively) as compared to good prognosis women.
  
  
  CONCLUSIONS
  The relatively high cancellation rate in patients with poor prognosis raises the question of the use of IVF modified natural cycle in this group.
authors.affiliation: Service de gynécologie-obstétrique et médecine de reproduction, hôpital Antoine-Béclère, AP-HP, 157, rue de Porte-de-Trivaux, 92141 Clamart, France. frederic.lamazou@abc.aphp.fr
authors.forename: F
authors.initials: F
authors.lastname: Lamazou
authors.forename: F
authors.initials: F
authors.lastname: Fuchs
authors.forename: M
authors.initials: M
authors.lastname: Grynberg
authors.forename: V
authors.initials: V
authors.lastname: Gallot
authors.forename: E
authors.initials: E
authors.lastname: Herzog
authors.forename: R
authors.initials: R
authors.lastname: Fanchin
authors.forename: N
authors.initials: N
authors.lastname: Frydman
authors.forename: R
authors.initials: R
authors.lastname: Frydman
mesh_terms: D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood / Q000172:deficiency; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods* / Q000706:statistics & numerical data; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D050498:Live Birth; D008597:Menstrual Cycle / Q000502:physiology*; D017063:Outcome Assessment, Health Care; D006080:Ovarian Follicle / Q000033:anatomy & histology; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D012189:Retrospective Studies; D017211:Treatment Failure; D016312:Treatment Refusal / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone