title: Limonoids from Meliaceae with lipid peroxidation inhibitory activity.
abstract: In this study the antioxidant activity of natural limonoids from Meliaceae swietenolide (1), 3,6-O,O-diacetylswietenolide (2), swietenine (3), swietemahonin G (4) and 2-hydroxyswietenine (5) were investigated along with the semi-synthetic analogues (6-25) of compounds 1, 3-4. Lipid peroxidation (LPO) inhibitory assays revealed 85.6, 13.3, 77.3, 61.2 and 24.6% inhibition for the natural compounds 1-5. Excellent antioxidant activity was seen for the semi-synthetic analogues 10 (98.3%), 16-17, 21-22 and 25 (100%), which were more active than the positive controls BHA (91.3%) and TBHQ (95.7%).
authors.affiliation: Department of Agricultural, Food and Nutritional Science, T6G 2P5, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Fowles
authors.forename: Baldwin S
authors.initials: BS
authors.lastname: Mootoo
authors.forename: Russel S
authors.initials: RS
authors.lastname: Ramsewak
authors.forename: William F
authors.initials: WF
authors.lastname: Reynolds
authors.forename: Muraleedharan G G
authors.initials: MG
authors.lastname: Nair
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D036701:Limonins / Q000737:chemistry* / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000975:Antioxidants; D036701:Limonins