title: Human leukocyte antigen-G in cancer: are they clinically relevant?
abstract: The immunotolerant human leukocyte antigen (HLA)-G has direct inhibitory effects on natural killer cells (NK), dendritic cells (DC), T cells and can induce tolerant regulatory cells. The expression of HLA-G has been correlated with the tolerance of the fetus, the acceptance of organ transplants, and the immune escape of tumor cells and virus-infected cells. In the context of malignancies, aberrant induction of HLA-G expression has been extensively investigated and its clinical relevance has been postulated. We here focus on the HLA-G expression in malignancies and its relevance to tumor cell immune escaping and disease progression.
authors.affiliation: Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, People's Republic of China. yanwhcom@yahoo.com
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Yan
mesh_terms: D006680:HLA Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology*; D019139:Tumor Escape / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I