title: The importance of tricuspid regurgitation and right ventricular overload in ICD/CRT recipients: beside the left, beyond the left.
abstract: Device therapy for advanced heart failure has become increasingly employed in the last 10 years. Several retrospective studies have postulated a harmful effect of implantable cardioverter-defibrillator (ICD) lead placement on tricuspid valve function and right heart hemodynamics, in particular among patients with preexisting pulmonary vascular overload and both left and right ventricular remodeling/dysfunction. This functional hypothesis is also supported by long-term clinical follow-up analyses of ICD and cardiac resynchronization therapy recipients. In this viewpoint, we propose that the possibility of worsening tricuspid regurgitation and consequent hemodynamic deterioration following device implantation should be considered in future studies, as well as in the preimplant evaluation of individual candidates among other clinical factors.
authors.affiliation: Department of Clinical Medicine, Cardiovascular and Immunological Sciences Federico II University, Naples, Italy. fazio@unina.it
authors.forename: Serafino
authors.initials: S
authors.lastname: Fazio
authors.forename: Guido
authors.initials: G
authors.lastname: Carlomagno
mesh_terms: D058409:Cardiac Resynchronization Therapy Devices; D017147:Defibrillators, Implantable; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy; D006352:Heart Ventricles / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D016896:Treatment Outcome; D014261:Tricuspid Valve / Q000503:physiopathology; D014262:Tricuspid Valve Insufficiency / Q000503:physiopathology* / Q000628:therapy; D020257:Ventricular Remodeling / Q000502:physiology