title: Non-cirrhotic and non-malignant acute extrahepatic portal vein thrombosis (PVT): short- and long-term results.
abstract: This observational cohort study reports the short- and long-term clinical outcomes of 31 patients admitted for acute non-malignant, non-cirrhotic portal vein thrombosis (PVT) over a 10-year period. Patients had a mean age of 43 years at admission and a mean duration of follow-up of 84 months. All patients were initially treated with anticoagulants. Complete recanalization occurred within 30 days after admission in 18 patients (58%), partially in nine patients (29%), and failed in four patients (13%). During follow-up, 10 patients (32%) had at least one episode of gastrointestinal bleeding. The probability of remaining bleed-free was 0.93 at 24 months and 0.61 at 48 months. Fundal varices were not controlled by endoscopic sclerotherapy, so all four patients underwent portosystemic shunt construction. To date, there has been no mortality. In conclusion, using a combination of different treatment options reduces the risk of death and late complications in patients with non-malignant, non-cirrhotic PVT.
authors.affiliation: Department of Vascular Surgery, University Clinical Centre Maribor, Maribor, Slovenia.
authors.forename: N
authors.initials: N
authors.lastname: Kobilica
authors.forename: M
authors.initials: M
authors.lastname: Skalicky
authors.forename: F
authors.initials: F
authors.lastname: Milotič
authors.forename: V
authors.initials: V
authors.lastname: Flis
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D011169:Portal Vein / Q000473:pathology*; D015911:Sclerotherapy; D036542:Tomography, Spiral Computed; D020246:Venous Thrombosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants