title: A TeNaCious foundation for the metastatic niche.
abstract: In the July issue of Nature Medicine, Massagué and colleagues define a biphasic role for the extracellular matrix protein tenascin C as a metastatic niche component in lung colonization by breast cancer cells. These results provide a rationale for designing therapies targeting metastatic progression by disrupting its very foundations.
authors.affiliation: Departments of Pediatrics and Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10021, USA.
authors.forename: Irina
authors.initials: I
authors.lastname: Matei
authors.forename: Cyrus M
authors.initials: CM
authors.lastname: Ghajar
authors.forename: David
authors.initials: D
authors.lastname: Lyden