title: A retrospective consecutive case series using mineralized allograft combined with recombinant human platelet-derived growth factor BB to treat moderate to severe osseous lesions.
abstract: This retrospective case series reports on the use of freeze-dried bone allograft (FDBA) combined with a purified recombinant protein of platelet-derived growth factor BB (PDGF-BB) for the treatment of periodontal intraosseous defects in 50 consecutive patients. The mean pretreatment measurements for clinical attachment level and probing depth were 7.9 ± 1.6 mm and 7.8 ± 1.4 mm, respectively. At 6 months, mean clinical attachment level was 3.9 ± 1.4 mm, reflecting an improvement of 4.1 ± 1.3 mm, whereas mean probing depth was reduced to 3.0 ± 1.2 mm, corresponding to a reduction of 4.8 ± 1.4 mm. These clinical results indicate that the combined use of FDBA and PDGF-BB can lead to substantial improvements in clinical parameters.
authors.affiliation: Department of Periodontics, Baltimore College of Dental Surgery, University of Maryland, Baltimore, Maryland, USA. p.rosen@psrperioimplant.com
authors.forename: Paul S
authors.initials: PS
authors.lastname: Rosen
authors.forename: Nicholas
authors.initials: N
authors.lastname: Toscano
authors.forename: Daniel
authors.initials: D
authors.lastname: Holzclaw
authors.forename: Mark A
authors.initials: MA
authors.lastname: Reynolds
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000145:classification / Q000601:surgery*; D000543:Alveoloplasty / Q000379:methods; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000077214:Becaplermin; D016025:Bone Transplantation / Q000379:methods*; D003094:Collagen; D015925:Cryopreservation; D012534:Dental Scaling / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D057747:Periodontal Debridement / Q000379:methods; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D020574:Proto-Oncogene Proteins c-sis / Q000627:therapeutic use*; D011994:Recombinant Proteins; D012189:Retrospective Studies; D016745:Root Planing / Q000379:methods; D013524:Surgical Flaps; D014184:Transplantation, Homologous
chemical_list: D043925:Angiogenesis Inducing Agents; D008567:Membranes, Artificial; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin; D003094:Collagen