title: [Abnormal expression and significance of MIR-184 in human renal carcinoma].
abstract: OBJECTIVE
  To explore the role of microRNA-184(MIR-184) in the development of renal cell carcinoma(RCC).
  
  
  METHODS
  The expressions of MIR-184 in 51 patients with RCC Investigated, normal adjacent tissues (ADTs) matched by fluorescence quantitative PCR technology (RT-qPCR) and the correlations analyzed between MIR-184 expression and the age, gender and clinical stage of RCC patients.
  
  
  RESULTS
  The average expression of MIR-184 in RCC was -14.664 6 ± 5.362 4, while that in ADTs was -10.408 7 ± 3.482 7(P<0.01). Bounded with the MIR-184 expression in RCC, patients were divided into lower-expression group and higher-expression group. Meanwhile, the RCC patients were divided into three groups according to the age, gender and clinical stage of the patients. Chi-square statistical analysis showed that the expression level of MIR-184 was not significantly correlated with the patient's age, gender and clinical stage (respectively: P>0.03, P>0.99, P>0.03).
  
  
  CONCLUSIONS
  MIR-184 in RCC was significantly lower than that in ADTs, which may have potential significance in the occurrence and development of RCC.
authors.affiliation: Department of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Hui-min
authors.initials: HM
authors.lastname: Leng
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Qian
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Qing-na
authors.initials: QN
authors.lastname: Zhai
authors.forename: Xian-xin
authors.initials: XX
authors.lastname: Li
authors.forename: Zhi-chen
authors.initials: ZC
authors.lastname: Guan
authors.forename: Yao-ting
authors.initials: YT
authors.lastname: Gui
authors.forename: Zhi-ming
authors.initials: ZM
authors.lastname: Cai
mesh_terms: D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged
chemical_list: C534424:MIRN184 microRNA, human; D035683:MicroRNAs