title: Peroxisome proliferator-activated receptor delta (PPARD) genetic variation and type 2 diabetes in middle-aged Chinese women.
abstract: Animal studies have shown that the peroxime proliferator-activated receptor delta (PPARD) gene regulates glucose metabolism and insulin sensitivity. Genetic variation in the PPARD gene might affect physical endurance and has been associated with obesity. We investigated the independent and modifying effect of variants in the PPARD gene with exercise participation and body mass index (BMI) on type 2 diabetes (T2D), using data from a genome-wide association study (GWAS) of middle-aged women living in Shanghai, China, with 1019 T2D cases and 1709 controls. The genotyping was performed using the Affymetrix Genome-Wide Human SNP Array 6.0 platform. Imputation was used to determine missing genotypes. Participation in exercise was assessed by a questionnaire. Anthropometric variables were measured by trained interviewers. The association between polymorphisms and T2D was assessed by logistic regression analyses. The combined effects of polymorphisms in the PPARD gene with exercise participation and BMI on T2D risk was assessed by conducting stratified analysis with exercise participation and BMI categories. No significant associations between PPARD and T2D were found in either genotyped or imputed SNPs and no effect modification between exercise participation and PPARD genetic variation was found, suggesting that PPARD is not a risk factor for T2D in this population.
authors.affiliation: Vanderbilt Epidemiology Center, Department of Medicine, Nashville, TN 37203-1738, USA. raquel.villegas@vanderbilt.edu
authors.forename: Raquel
authors.initials: R
authors.lastname: Villegas
authors.forename: Scott
authors.initials: S
authors.lastname: Williams
authors.forename: Yutang
authors.initials: Y
authors.lastname: Gao
authors.forename: Qiuyin
authors.initials: Q
authors.lastname: Cai
authors.forename: Honglan
authors.initials: H
authors.lastname: Li
authors.forename: Tom
authors.initials: T
authors.lastname: Elasy
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
authors.forename: Todd
authors.initials: T
authors.lastname: Edwards
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Jirong
authors.initials: J
authors.lastname: Long
authors.forename: Xiao
authors.initials: X
authors.lastname: Ou Shu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D047494:PPAR delta / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D047494:PPAR delta