title: Selective IgA deficiency in autoimmune diseases.
abstract: Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), celiac disease (CD), myasthenia gravis (MG) and rheumatoid arthritis (RA) on the basis of both our own recent large-scale screening results and literature data. Genetic factors are important for the development of both IgAD and various autoimmune disorders, including GD, SLE, T1D, CD, MG and RA, and a strong association with the major histocompatibility complex (MHC) region has been reported. In addition, non-MHC genes, such as interferon-induced helicase 1 (IFIH1) and c-type lectin domain family 16, member A (CLEC16A), are also associated with the development of IgAD and some of the above diseases. This indicates a possible common genetic background. In this review, we present suggestive evidence for a shared genetic predisposition between these disorders.
authors.affiliation: Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Shen
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Vyse
authors.forename: Vidya
authors.initials: V
authors.lastname: Anand
authors.forename: Iva
authors.initials: I
authors.lastname: Gunnarson
authors.forename: Gunnar
authors.initials: G
authors.lastname: Sturfelt
authors.forename: Solbritt
authors.initials: S
authors.lastname: Rantapää-Dahlqvist
authors.forename: Kerstin
authors.initials: K
authors.lastname: Elvin
authors.forename: Lennart
authors.initials: L
authors.lastname: Truedsson
authors.forename: Bengt A
authors.initials: BA
authors.lastname: Andersson
authors.forename: Charlotte
authors.initials: C
authors.lastname: Dahle
authors.forename: Eva
authors.initials: E
authors.lastname: Ortqvist
authors.forename: Peter K
authors.initials: PK
authors.lastname: Gregersen
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Behrens
authors.forename: Lennart
authors.initials: L
authors.lastname: Hammarström
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D015415:Biomarkers; D006801:Humans; D017098:IgA Deficiency / Q000150:complications* / Q000453:epidemiology / Q000276:immunology
chemical_list: D015415:Biomarkers