title: Impact of diabetes on postinfarction heart failure and left ventricular remodeling.
abstract: Diabetes mellitus, the metabolic syndrome, and the underlying insulin resistance are increasingly associated with diastolic dysfunction and reduced stress tolerance. The poor prognosis associated with heart failure in patients with diabetes after myocardial infarction is likely attributable to many factors, important among which is the metabolic impact from insulin resistance and hyperglycemia on the regulation of microvascular perfusion and energy generation in the cardiac myocyte. This review summarizes epidemiologic, pathophysiologic, diagnostic, and therapeutic data related to diabetes and heart failure in acute myocardial infarction and discusses novel perceptions and strategies that hold promise for the future and deserve further investigation.
authors.affiliation: Klinic for Endocrinology, Diabetes and Vascular Medicine, Klinikum Bogenhausen, Städtische Klinikum München GmbH, Englschalkingerstrasse 77, 81925, München, Germany. vonbibra@gmx.de
authors.forename: Helene
authors.initials: H
authors.lastname: von Bibra
authors.forename: Martin
authors.initials: M
authors.lastname: St John Sutton
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003326:Coronary Circulation; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D004730:Endothelium, Vascular / Q000503:physiopathology; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D009203:Myocardial Infarction / Q000150:complications*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D020257:Ventricular Remodeling
chemical_list: D001786:Blood Glucose