title: The role of microRNAs in Epstein-Barr virus latency and lytic reactivation.
abstract: Oncogenic viruses reprogram host gene expression driving proliferation, ensuring survival, and evading the immune response. The recent appreciation of microRNAs (miRNAs) as small non-coding RNAs that broadly regulate gene expression has provided new insight into this complex scheme of host control. This review highlights the role of viral and cellular miRNAs during the latent and lytic phases of the EBV life cycle.
authors.affiliation: Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Forte
authors.forename: Micah A
authors.initials: MA
authors.lastname: Luftig
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000821:virology; D017124:Conserved Sequence; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000276:immunology / Q000821:virology*; D055354:Exosomes / Q000276:immunology / Q000378:metabolism / Q000821:virology; D020869:Gene Expression Profiling; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000276:immunology / Q000821:virology*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D034743:RNA-Induced Silencing Complex / Q000276:immunology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D014775:Virus Activation / Q000502:physiology*; D017735:Virus Latency / Q000502:physiology*
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger; D012367:RNA, Viral; D034743:RNA-Induced Silencing Complex; D014764:Viral Proteins