title: Inclusion body myositis in Alzheimer's disease.
abstract: BACKGROUND
  The prevalence of Alzheimer's disease is increasing. Could findings of similar deposits in brain and muscle tissue explain this increase? The purpose of this report is to illustrate that Alzheimer's disease and inclusion body myositis may share a common aetiology.
  
  
  RESULTS
  We present a case where Alzheimer's disease and inclusion body myositis coexist in the same patient. Amyloid-beta deposition and the presence of phosphorylated tau protein have been noted in brain tissue and in muscle biopsy from patients with these disorders.
  
  
  METHODS
  Electrophysiological methods are needed for proper diagnosis of this brain and muscle disorder. Recent data on deposit structures in both conditions may indicate an environmental aetiology for Alzheimer's disease and inclusion body myositis.
  
  
  CONCLUSIONS
  By combining electrophysiological methods with muscle biopsy in cases of Alzheimer's disease, the possible aetiological connection between simultaneous affection of both muscle and brain in this condition can be established.
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. per.roos@ki.se
authors.forename: P M
authors.initials: PM
authors.lastname: Roos
authors.forename: O
authors.initials: O
authors.lastname: Vesterberg
authors.forename: M
authors.initials: M
authors.lastname: Nordberg
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography / Q000379:methods; D005260:Female; D006801:Humans; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology*; D009133:Muscular Atrophy / Q000209:etiology; D018979:Myositis, Inclusion Body / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins