title: [Two cases of drug-induced intrathoracic lesions caused by mesalazine in patients with ulcerative colitis].
abstract: We encountered 2 cases of drug-induced intrathoracic lesions caused by allergic reactions to mesalazine in patients with ulcerative colitis. Case 1: A 26-year-old man had a fever, cough and exertional dyspnea after 1 month of mesalazine treatment. He was hospitalized because of bilateral pulmonary infiltrates on a chest X-ray film. Case 2: A 27-year-old woman complained of fever and left back pain that exacerbated after 2 weeks of mesalazine treatment. She was hospitalized because of bilateral pulmonary effusions on chest CT. Both patients showed a positive reaction to a drug lymphocyte stimulation tests (DLST) for mesalazine. The first case was given a diagnosis of eosinophilic pneumonia by bronchoscopic examination, and responded to steroid therapy after discontinuation of mesalazine. The second case was given a diagnosis of pleuritis and improved on cessation of Mesalazine treatment.
authors.affiliation: National Hospital Organization Kochi National Hospital.
authors.forename: Hisanori
authors.initials: H
authors.lastname: Machida
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Shinohara
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hatakeyama
authors.forename: Mami
authors.initials: M
authors.lastname: Inayama
authors.forename: Emiko
authors.initials: E
authors.lastname: Hosokawa
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ogushi
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000009:adverse effects*; D010998:Pleurisy / Q000139:chemically induced*; D011657:Pulmonary Eosinophilia / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine