title: Gene editing in stem cells hits the target.
abstract: Two recent reports describe promising, highly efficient methods to modify genes in pluripotent stem cells using zinc finger nuclease (ZFN)-mediated (Soldner et al., 2011) or helper-dependent adenovirus (HDAdV)-mediated (Liu et al., 2011b) gene modification. These technical developments will have far ranging effects on the rapidly growing field of regenerative medicine.
authors.affiliation: The Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
authors.forename: Ho Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Clive Niels
authors.initials: CN
authors.lastname: Svendsen