title: [Influence of iridoid from Valeriana jatamansi on 5-HT and 5-HIAA in rats with irritable bowel syndrome].
abstract: OBJECTIVE
  To investigate the mechanism of iridoid from Valeriana jatamansi treating irritable bowel syndrome.
  
  
  METHODS
  Sixty male SD rats were equally divided into 6 groups (2 controls, 1 model and 3 treatment doses) with 10 rats per group. The test groups were administered with iridoid (24.92, 12.46, 6. 23 mg x kg(-1)) while the control groups were administered with fluoxetine (2.5 mg x kg(-1), positive control) or distilled water (negative control). The model was established by chronic stress and independent feeding. The influence of iridoid from V. jatamansi on 5-HT and 5-HIAA in colon, serum and hypothalamic were observed in all groups.
  
  
  RESULTS
  In the model group, the content of 5-HT in colon and serum increased significantly, but the content of 5-HT in hypothalamic decreased significantly. The content of 5-HIAA and the value of 5-HT/5-HIAA had no significant change. In three iridoid-treated groups, the content of 5-HT in colon and serum decreased, but the content of 5-HT in hypothalamic increased. The content of 5-HIAA had no significant change. The value of 5-HT/5-HIAA in colon and serum reduced.
  
  
  CONCLUSIONS
  The mechanism of iridoid from V. jatamansi treating irritable bowel syndrome may be related to the regulation effect to the levels of 5-HT from Gastrointestinal to central nervous system.
authors.affiliation: Beijing University of Chinese Medicine, Beijing 100029, China. xingliyan3@126.com
authors.forename: Xingli
authors.initials: X
authors.lastname: Yan
authors.forename: Ying
authors.initials: Y
authors.lastname: Hong
authors.forename: Jinli
authors.initials: J
authors.lastname: Shi
authors.forename: Yi
authors.initials: Y
authors.lastname: Qin
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Chen
authors.forename: Ren
authors.initials: R
authors.lastname: Zhao
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Cui
authors.forename: Xuemin
authors.initials: X
authors.lastname: Gao
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003106:Colon / Q000187:drug effects / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000097:blood* / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D039823:Iridoids / Q000627:therapeutic use*; D043183:Irritable Bowel Syndrome / Q000097:blood* / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000097:blood* / Q000378:metabolism; D014632:Valerian / Q000737:chemistry*
chemical_list: D039823:Iridoids; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid