title: Potential teratogenic effects of allopurinol: a case report.
abstract: We report on a case of a multiple congenital anomalies in a newborn infant whose mother was on allopurinol treatment through the pregnancy. The pattern of congenital anomalies that was noted in our patient was similar to the pattern described in a number of published reports following mycophenolate mofetil [CellCept®] treatment during pregnancy. The anomalies present in our patient include: diaphragmatic hernia, unilateral microtia and absence of external auditory canal, micrognathia, microphthalmia, optic nerve hypoplasia, hypoplasia of the corpus callosum, unilateral renal agenesis, pulmonary agenesis, and cleft lip and palate. Since both allopurinol and mycophenolate mofetil act by disrupting purine biosynthesis and given the similarities in anomalies seen after prenatal exposure, we suggest that allopurinol should also be considered a teratogen.
authors.affiliation: Department of Pediatrics & Child Health and Biochemistry, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Mariya
authors.initials: M
authors.lastname: Kozenko
authors.forename: David
authors.initials: D
authors.lastname: Grynspan
authors.forename: Titi
authors.initials: T
authors.lastname: Oluyomi-Obi
authors.forename: Daniel
authors.initials: D
authors.lastname: Sitar
authors.forename: Alison M
authors.initials: AM
authors.lastname: Elliott
authors.forename: Bernard N
authors.initials: BN
authors.lastname: Chodirker
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D000963:Antimetabolites / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007669:Kidney Calculi / Q000188:drug therapy; D008297:Male; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011297:Prenatal Exposure Delayed Effects; D011687:Purines / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D013723:Teratogens
chemical_list: D000963:Antimetabolites; D011687:Purines; D013723:Teratogens; D000493:Allopurinol; D009173:Mycophenolic Acid