title: Proline-based reduced dipeptides as recyclable and highly enantioselective organocatalysts for asymmetric Michael addition.
abstract: A series of novel proline-based reduced dipeptides was developed and evaluated for a direct Michael addition of ketones and aldehydes to nitroalkenes. Excellent yields (up to 95%), diastereoselectivities (up to 98% dr) and enantioselectivities (up to 98% ee) were achieved in the presence of 5 mol% catalyst without any additional additives at room temperature.
authors.affiliation: School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Cao
authors.forename: Ge
authors.initials: G
authors.lastname: Wang
authors.forename: Richeng
authors.initials: R
authors.lastname: Zhang
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wei
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Huichao
authors.initials: H
authors.lastname: Sun
authors.forename: Ligong
authors.initials: L
authors.lastname: Chen
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry; D011392:Proline / Q000737:chemistry*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000475:Alkenes; D004151:Dipeptides; D007659:Ketones; D009574:Nitro Compounds; D011714:Pyrans; D011392:Proline