title: Chemokines plasma levels in preterm newborns of preeclamptic mothers.
abstract: Information on leukocyte activation in newborn infants of preeclamptic mothers is scarce. IL-8 and GRO-α are the main pro-inflammatory cytokines involved in leukocyte activation. The objective was to evaluate IL-8 and GRO-α plasma levels in preterm newborns infants of preeclamptic mothers. Newborns with gestational age<36 weeks and birth weight<2000 g were included and divided: non-preeclamptic (n=64) and preeclamptic groups (n=55). Exclusion criteria were major congenital malformations, inborn errors of metabolism or chromosomal anomalies, congenital infections, death in delivery room, and maternal chronic hypertension without preeclampsia. IL-8 and GRO-α were measured by enzyme immunoassay in the first 48 h. Groups were similar in birth weight, gestational age, Apgar scores at 5 min, sepsis, RDS, mechanical ventilation, TPN, NEC, intraventricular hemorrhage and death. The preeclamptic group had more neutropenia, SGA, cesarean section, and less rupture of membranes>18 h. IL-8 was higher in the non-preeclamptic [157.1 pg/mL (86.4-261.3) and 26.54 pg/mL (3.6-87.2) p<0.001]. GRO-α levels were similar in both groups [229.5 pg/mL (116.6-321.3) and 185.5 pg/mL (63.9-306.7) p=0.236]. After multiple regression analysis only absence of preeclampsia was associated with high IL-8 levels. Our data suggest that leukocyte activation may be impaired in infants of preeclamptic mothers.
authors.affiliation: Department of Pediatrics, Newborn Section, Universidade Federal do Rio Grande do Sul and Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Fabrizia R S
authors.initials: FR
authors.lastname: Faulhaber
authors.forename: Rita C
authors.initials: RC
authors.lastname: Silveira
authors.forename: Ana P
authors.initials: AP
authors.lastname: Vargas
authors.forename: Renato S
authors.initials: RS
authors.lastname: Procianoy
mesh_terms: D000328:Adult; D001034:Apgar Score; D054360:Chemokine CXCL1 / Q000097:blood*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D057230:Limit of Detection; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
chemical_list: C475829:CXCL1 protein, human; D054360:Chemokine CXCL1; D016209:Interleukin-8