title: Surgical timing of the subependymal giant cell astrocytoma (SEGA) with the patients of tuberous sclerosis complex.
abstract: OBJECTIVE
  Tuberous sclerosis complex has shown a wide variety of clinical, pathologic and radiologic manifestations. Many tumor types are found in tuberous sclerosis, which includes subependimal giant cell astrositoma. The aim of this study is to focus on surgical timing of the tumor.
  
  
  METHODS
  This study included 37 children with tuberous sclerosis presenting to Erciyes Univercity Medical School, whose hospital record were retrospectively evaluated between 1995 and 2010. Of the 5 patients had diagnosed with the subependymal giant cell astrocytoma and three patients were opereted on.
  
  
  RESULTS
  In the 27 of the patients had subependimal nodules (73%), cortical tubers were in the 19 patients (51,4%), giant cell astrositoma (SEGA) were in the 5 patients (13,5%). Mental retardation in different level was detected in the 18 patients (48.6%). The other clinical findings of the patients were angiomyolipomas (37.8%), hypomelanotic macules (91.9%), Convulsion (54.1%), adenoma sebaceum (32.4%) , West syndrome (16.22%), shagreeen patch (16.2%), intracardiac tumor (37.8%), subungual fibroma (2.7%), fibroadenom in the neck (2.7%).
  
  
  CONCLUSIONS
  A multidisciplinary approach is essential for an early, accurate diagnosis and proper management of affected individuals. The early surgical menagement for subependimal giant cell astrocytoma are recommended, and also periodic monitoring even for asymptomatic patients with subependymal nodules.
authors.affiliation: Bozok University, Faculty of Medicine, Department of Neurosurgery, Yozgat, Turkey. mehmetali.ekici@gmail.com
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Ekici
authors.forename: Sefer
authors.initials: S
authors.lastname: Kumandas
authors.forename: Huseyin
authors.initials: H
authors.lastname: Per
authors.forename: Arzu
authors.initials: A
authors.lastname: Ekici
authors.forename: Bulent
authors.initials: B
authors.lastname: Tucer
authors.forename: Hakan
authors.initials: H
authors.lastname: Gumus
authors.forename: Ozlem
authors.initials: O
authors.lastname: Canoz
authors.forename: Ali
authors.initials: A
authors.lastname: Kurtsoy
mesh_terms: D000293:Adolescent; D001254:Astrocytoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D002648:Child; D005123:Eye / Q000473:pathology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006261:Headache / Q000209:etiology; D006801:Humans; D006948:Hyperkinesis / Q000209:etiology; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009206:Myocardium / Q000473:pathology; D019635:Neurosurgical Procedures / Q000379:methods*; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology; D012867:Skin / Q000473:pathology; D014402:Tuberous Sclerosis / Q000150:complications* / Q000378:metabolism; D014839:Vomiting / Q000209:etiology
chemical_list: D005904:Glial Fibrillary Acidic Protein