title: Glutathione-S-transferase M1 and T1 genes and gastric cancer: a case control study in North Indian population.
abstract: BACKGROUND
  Difference in the capacity of xenobiotic metabolising enzymes might be an important factor in genetic susceptibility to cancer.
  
  
  METHODS
  A case control study involving forty one gastric cancer patients and one hundred and thirty controls was carried out to determine the frequency of GSTM1 and GSTT1 null genotypes. The frequency of GSTM1 and GSTT1 null genotype was observed by carrying out multiplex PCR.
  
  
  RESULTS
  There was no difference in the frequencies of the GSTM1 and GSTT1 null and the combined GSTM1 and GSTT1 null genotype between patients and control.
  
  
  CONCLUSIONS
  Our data suggest that GSTM1 and GSTT1 status may not influence the risk of developing gastric cancer.
authors.affiliation: Cardiovascular Toxicology Division, Indian Institute of Toxicology Research, Lucknow.
authors.forename: Deepmala
authors.initials: D
authors.lastname: Yadav
authors.forename: Richa
authors.initials: R
authors.lastname: Chandra
authors.forename: Rajan
authors.initials: R
authors.lastname: Saxena
authors.forename: Deepti
authors.initials: D
authors.lastname: Agarwal
authors.forename: Mohit
authors.initials: M
authors.lastname: Agarwal
authors.forename: Tanima
authors.initials: T
authors.lastname: Ghosh
authors.forename: Deepa
authors.initials: D
authors.lastname: Agrawal
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1