title: Jasisoquinolines A and B, architecturally new isoquinolines, from a marine sponge Jaspis sp.
abstract: Two architecturally new isoquinolines, jasisoquinolines A and B, were isolated from a marine sponge Jaspis sp. as cathepsin B inhibitors. Their structures were determined by a combination of spectroscopic analyses and chemical methods. Both jasisoquinolines A and B inhibit cathepsin B with an IC(50) value of 10 μg/mL.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Imae
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takada
authors.forename: Shuhei
authors.initials: S
authors.lastname: Murayama
authors.forename: Shigeru
authors.initials: S
authors.lastname: Okada
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ise
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
mesh_terms: D000818:Animals; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007546:Isoquinolines; C568018:jasisoquinoline A; C568019:jasisoquinoline B