title: Antibacterial and modulatory effect of Stryphnodendron rotundifolium.
abstract: BACKGROUND
  Stryphnodendron rotundifolium Mart. (Leguminosae), a tree in Northeast Brazil (Chapada do Araripe), is used in popular medicine to treat different processes such as inflammation and infectious diseases, mainly caused by bacterial pathogens.
  
  
  OBJECTIVE
  This study determined the modulatory and antimicrobial activity of the hydroethanol extract of dried stem bark, the most used form of this natural product, as a remedy by the traditional communities, against standard and clinical isolates of Escherichia coli and Staphylococcus aureus.
  
  
  METHODS
  The antibacterial and modulatory activities of the hydroalcoholic extract from the leaves were obtained by maceration/hydrodistillation method and assayed by microdilution.
  
  
  RESULTS
  In the microbiological assays, growth inhibition was demonstrated by this extract against the bacterial strains tested, with minimal inhibitory concentration (MIC) values of 512 μg/mL. However, when a subinhibitory concentration (MIC/8 = 64 μg/mL) was combined with conventional antimicrobial drugs (gentamicin, kanamycin, amikacin and neomycin), the extract showed a potentiating effect, reducing the MIC for all drugs assayed in a range between 312.5 and 2.4 μg/mL.
  
  
  CONCLUSIONS
  We indicate that the extract of S. rotundifolium showed potential synergistic antibiotic activity. With the results obtained, these extracts proved to be a promising source of antibacterial and modulatory agents.
authors.affiliation: Laboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri, Crato, Brazil.
authors.forename: Dayanne R
authors.initials: DR
authors.lastname: Oliveira
authors.forename: Francisco E
authors.initials: FE
authors.lastname: Brito
authors.forename: Elizângela B
authors.initials: EB
authors.lastname: Bento
authors.forename: Edinardo F F
authors.initials: EF
authors.lastname: Matias
authors.forename: Ana Carla A
authors.initials: AC
authors.lastname: Sousa
authors.forename: Jose G M
authors.initials: JG
authors.lastname: Costa
authors.forename: Henrique D M
authors.initials: HD
authors.lastname: Coutinho
authors.forename: Marta R
authors.initials: MR
authors.lastname: Kerntopf
authors.forename: Irwin R A
authors.initials: IR
authors.lastname: Menezes
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects; D020834:Ethnopharmacology; D007887:Fabaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D010936:Plant Extracts