title: [Usefulness of reticulocyte hemoglobin equivalent for the safety of pre-operative autologous blood donation].
abstract: Pre-operative autologous blood donation (PABD) provides safe blood for patients at the expense of the risk of iron deficiency anemia that may compromise the patients. The reticulocyte hemoglobin equivalent (RET-He) is an indirect measure of the functional iron available for the erythropoiesis over the previous 2-3 days. The aim of this study was to evaluate the clinical usefulness of RET-He quickly measured by the automated hematology analyzer Sysmex XE-2100 in patients undergoing PABD at our hospital. Receiver-operating characteristic curve analysis revealed that RET-He was reliable in the diagnosis of iron deficiency anemia. Two of 14 patients in the absence of post-PABD iron replacement developed marked anemia with low RET-He levels after PABD, suggesting that this anemia was due to iron deficiency. Of 26 patients receiving post-PABD iron replacement, 8 who had already showed low RET-He levels at PABD developed statistically significant reduction in hemoglobin levels after PABD despite adequate iron replacement, indicating that the 8 patients had iron deficiency prior to PABD. These findings suggest that automated measurement of RET-He may contribute to improve the safety of PABD.
authors.affiliation: Department of Clinical Laboratory, Kanazawa University Hospital, Kanazawa 920-8641, Japan. sibayama-knz@umin.ac.jp
authors.forename: Masami
authors.initials: M
authors.lastname: Shibayama
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Takami
authors.forename: Mika
authors.initials: M
authors.lastname: Kimura
authors.forename: Sayuri
authors.initials: S
authors.lastname: Takamichi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Sakai
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors; D001804:Blood Transfusion, Autologous; D005260:Female; D006403:Hematologic Tests / Q000295:instrumentation / Q000379:methods*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012156:Reticulocytes / Q000737:chemistry*; D012449:Safety; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006454:Hemoglobins