title: [Effect of sodium cantharidinate on the angiogenesis of nude mice with human gastric cancer].
abstract: OBJECTIVE
  To study the effect of sodium cantharidinate on the angiogenesis of nude mice with human gastric cancer.
  
  
  METHODS
  Nude mice xenograft models of human gastric cancer were established by injecting gastric carcinoma cell BGC823 into peritoneal. Expression of VEGF and MVD labeling by CD34 in human gastric cancer cells were measured by immunohistochemistry.
  
  
  RESULTS
  Expression scores of VEGF in medium dose and high dose group with sodium cantharidinate treatment were lower than those in low dose and control group (P < 0.01). There was no significant difference between medium dose and high dose group or low dose and control group (P > 0.05). MVD values in medium and high dose group with sodium cantharidinate treatment were lower than those in low dose and control group (P < 0.01), but there was no significant difference between medium dose and high dose group (P > 0.05).
  
  
  CONCLUSIONS
  sodium cantharidinate can inhibit the growth of the tumor by down-regulating VEGF expression of the tumour cell and the angiogenesis of the tumour.
authors.affiliation: Fundamental education Department of Anhui College of Chinese Traditional Medicine, Wuhu 241000, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liang
authors.forename: Ming-Yan
authors.initials: MY
authors.lastname: Wang
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Huang
authors.forename: Ai-Jian
authors.initials: AJ
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology; D002193:Cantharidin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D008419:Materia Medica / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D055806:Microvessels; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D008419:Materia Medica; D042442:Vascular Endothelial Growth Factors; D002193:Cantharidin