title: MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma.
abstract: MiR-106b is frequently up-regulated in various types of human cancer including laryngeal carcinoma. However the underlying mechanism of miR-106b involved in laryngeal carcinoma remains elusive. Here we showed that reduction of miR-106b induced cell cycle G0/G1 arrest by targeting tumor suppressor RB in human laryngeal carcinoma cells. Further, Introducing RB cDNA without 3'UTR abrogated miR-106b-induced cell proliferation. Finally, there was an inverse relationship between RB and miR-106b expression in laryngeal carcinoma tissues. To our knowledge, these data indicate for the first time that miR-106b directly regulate cell cycle by targeting RB in laryngeal carcinoma and that miR-106b could be potential therapeutic approaches for laryngeal carcinoma.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Taizhou People's Hospital, Taizhou 225300, PR China. entcaikemin7173@126.com
authors.forename: Kemin
authors.initials: K
authors.lastname: Cai
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Xueli
authors.initials: X
authors.lastname: Bao
mesh_terms: D020413:3' Untranslated Regions; D048708:Cell Growth Processes / Q000235:genetics; D045744:Cell Line, Tumor; D018076:DNA, Complementary / Q000008:administration & dosage / Q000235:genetics; D016193:G1 Phase / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000628:therapy; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage / Q000235:genetics; D016192:Resting Phase, Cell Cycle / Q000235:genetics; D016160:Retinoblastoma Protein / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D014162:Transfection
chemical_list: D020413:3' Untranslated Regions; D018076:DNA, Complementary; C542541:MIRN106 microRNA, human; D035683:MicroRNAs; D016376:Oligonucleotides, Antisense; D016160:Retinoblastoma Protein