title: Novel microbial transformation of resibufogenin by Fusarium solani.
abstract: In this paper, microbial transformation of resibufogenin by Fusarium solani AS 3.1829 was investigated, and five transformed products were isolated and identified as 3-ketone-resibufogenin (2), 3-one-cyclic 3-(1,2-dimethyl-1,2-ethanediylacetal)-resibufogenin (3), 3-dimethoxyl-resibufogenin (4), 3-epi-resibufogenin (5), and 3-epi-15α-hydroxy-7βH-bufalin (6), respectively. Among them, 3, 4, and 6 are new compounds, and the rare double oxidization of C-3 was reported. In addition, the cytotoxicities of transformed products were also investigated.
authors.affiliation: Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing 100029, China.
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Xin
authors.forename: Dong-hai
authors.initials: DH
authors.lastname: Su
authors.forename: Deng
authors.initials: D
authors.lastname: Sa
authors.forename: Yan
authors.initials: Y
authors.lastname: Tian
authors.forename: Bao-Jing
authors.initials: BJ
authors.lastname: Zhang
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Ma
authors.forename: Lei
authors.initials: L
authors.lastname: An
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Huang
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Yao
authors.forename: Xun
authors.initials: X
authors.lastname: Cui
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001711:Biotransformation; D002018:Bufanolides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005670:Fusarium / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000970:Antineoplastic Agents; D002018:Bufanolides; C005734:bufogenin; C022777:bufalin