title: Synthesis and biological activity of new 1,3-dioxolanes as potential antibacterial and antifungal compounds.
abstract: A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possible antibacterial and antifungal activity. Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity against S. aureus, S. epidermidis, E. faecalis and P. aeruginosa.
authors.affiliation: Department of Chemistry, Faculty of Engineering, Istanbul University, 34320 Avcılar, Istanbul, Turkey.
authors.forename: Hatice Başpınar
authors.initials: HB
authors.lastname: Küçük
authors.forename: Ayşe
authors.initials: A
authors.lastname: Yusufoğlu
authors.forename: Emel
authors.initials: E
authors.lastname: Mataracı
authors.forename: Sibel
authors.initials: S
authors.lastname: Döşler
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D002851:Chromatography, High Pressure Liquid; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D019946:Propylene Glycol / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004148:Dioxolanes; C013243:salicylaldehyde; D019946:Propylene Glycol