title: Sesterterpenes from the tropical sponge Coscinoderma sp.
abstract: Eight new sesterterpenes (2, 5, and 10-15), including structurally related pentaprenyl hydroquinones (2 and 5), and seven known ones of the same structural classes were isolated from the sponge Coscinoderma sp., collected from Chuuk Island, Micronesia. On the basis of the results of combined spectroscopic analyses, the new compounds were determined to be derivatives of the halisulfates and suvanine. These compounds exhibited moderate cytotoxicity against the K562 cell line and inhibitory activities against isocitrate lyase, sortase A, and Na+/K+-ATPase; significant structure-activity relationships were evident.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Jaemin
authors.initials: J
authors.lastname: Bae
authors.forename: Ju-Eun
authors.initials: JE
authors.lastname: Jeon
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Chung J
authors.initials: CJ
authors.lastname: Sim
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D003546:Cysteine Endopeptidases; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors; D020014:K562 Cells; D008849:Micronesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001426:Bacterial Proteins; D054830:Sesterterpenes; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases; D007522:Isocitrate Lyase; D000254:Sodium-Potassium-Exchanging ATPase