title: Wide dissemination of Pseudomonas aeruginosa producing beta-lactamase blaKPC-2 gene in Colombia.
abstract: Ten bla(KPC-2)-harboring Pseudomonas aeruginosa isolates from hospitals located in five different Colombian cities have been characterized. Isolates were multidrug resistant, belonged to five different pulsotypes, and possessed naturally chromosome-encoded bla(AmpC) and bla(OXA-50) genes and the acquired bla(KPC-2) gene. In most cases, the bla(KPC-2) genes were carried by plasmids of different sizes and were associated with Tn4401b or a new structure containing only part of the Tn4401 sequence. This study revealed that several clones of P. aeruginosa producing bla(KPC-2) are disseminating in Colombia.
authors.affiliation: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc 94275 Le Kremlin-Bicêtre Cedex, Paris, France.
authors.forename: Gaelle
authors.initials: G
authors.lastname: Cuzon
authors.forename: Thierry
authors.initials: T
authors.lastname: Naas
authors.forename: Maria-Virginia
authors.initials: MV
authors.lastname: Villegas
authors.forename: Adriana
authors.initials: A
authors.lastname: Correa
authors.forename: John P
authors.initials: JP
authors.lastname: Quinn
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003105:Colombia; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D016133:Polymerase Chain Reaction; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases