title: Nanofibrous scaffolds for dental and craniofacial applications.
abstract: Tissue-engineering solutions often harness biomimetic materials to support cells for functional tissue regeneration. Three-dimensional scaffolds can create a multi-scale environment capable of facilitating cell adhesion, proliferation, and differentiation. One such multi-scale scaffold incorporates nanofibrous features to mimic the extracellular matrix along with a porous network for the regeneration of a variety of tissues. This review will discuss nanofibrous scaffold synthesis/fabrication, biological effects of nanofibers, their tissue- engineering applications in bone, cartilage, enamel, dentin, and periodontium, patient-specific scaffolds, and incorporated growth factor delivery systems. Nanofibrous scaffolds cannot only further the field of craniofacial regeneration but also advance technology for tissue-engineered replacements in many physiological systems.
authors.affiliation: Department of Biomedical Engineering, 1011 North University Ave., Room 2211, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gupte
authors.forename: P X
authors.initials: PX
authors.lastname: Ma
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D001861:Bone Regeneration; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D003743:Dental Enamel / Q000502:physiology; D003804:Dentin / Q000502:physiology; D004337:Drug Carriers; D055664:Electrochemical Techniques; D006801:Humans; D057139:Nanofibers; D054118:Nanospheres; D010513:Periodontal Ligament / Q000166:cytology / Q000502:physiology; D044367:Phase Transition; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D004337:Drug Carriers