title: Differentiating inherited human herpesvirus type 6 genome from primary human herpesvirus type 6 infection by means of dried blood spot from the newborn screening card.
abstract: To differentiate active human herpesvirus type 6 (HHV-6) infection from inherited HHV-6 (iHHV-6), we analyzed dried blood spots from archived newborn screening cards in 3 patients with high HHV-6 DNA copy numbers. Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. In 1 patient, the absence of HHV-6 DNA excluded iHHV-6.
authors.affiliation: Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria. volker.strenger@medunigraz.at
authors.forename: Volker
authors.initials: V
authors.lastname: Strenger
authors.forename: Klaus
authors.initials: K
authors.lastname: Pfurtscheller
authors.forename: Gerald
authors.initials: G
authors.lastname: Wendelin
authors.forename: Stephan W
authors.initials: SW
authors.lastname: Aberle
authors.forename: Elisabeth P
authors.initials: EP
authors.lastname: Nacheva
authors.forename: Bettina
authors.initials: B
authors.lastname: Zöhrer
authors.forename: Werner
authors.initials: W
authors.lastname: Zenz
authors.forename: Bert
authors.initials: B
authors.lastname: Nagel
authors.forename: Gerfried
authors.initials: G
authors.lastname: Zobel
authors.forename: Therese
authors.initials: T
authors.lastname: Popow-Kraupp
mesh_terms: D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D059788:Dried Blood Spot Testing; D005260:Female; D016679:Genome, Viral; D006566:Herpesviridae Infections / Q000151:congenital* / Q000175:diagnosis*; D015654:Herpesvirus 6, Human / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D016133:Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral