title: [Type 4 advanced gastric cancer responding to histological complete response after neoadjuvant S-1 combined with CDDP therapy-report of a case].
abstract: A 75-year-old man with type 4 advanced gastric cancer was referred to our hospital. We diagnosed the tumor as cStage III B(cT4a, cN2, cM0)gastric cancer. We selected neoadjuvant S-1 combined with CDDP therapy for him. After 2 courses of chemotherapy, the extension of the gastric wall improved. After an additional 2 courses of chemotherapy, the primary tumor revealed a partial response(PR), judged from a barium meal study and upper GI endoscopic findings, and a total gastrectomy with lymph node dissection was performed. The pathological specimens showed no cancer cells in the gastric wall and lymph nodes, so the histological effect was judged as Grade 3.
authors.affiliation: Dept. of Surgery, Fukui Prefectural Hospital.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asaumi
authors.forename: Tamon
authors.initials: T
authors.lastname: Miyanaga
authors.forename: Homare
authors.initials: H
authors.lastname: Ito
authors.forename: Koichiro
authors.initials: K
authors.lastname: Sawada
authors.forename: Manami
authors.initials: M
authors.lastname: Fujita
authors.forename: Manami
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yagi
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kitamura
authors.forename: Mitsuyasu
authors.initials: M
authors.lastname: Hirano
authors.forename: Kazuya
authors.initials: K
authors.lastname: Maeda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hayashida
authors.forename: Koji
authors.initials: K
authors.lastname: Ohta
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Kenji
authors.initials: K
authors.lastname: Doden
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hattori
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hashizume
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Kaizaki
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin