title: [Risk factor analysis of post-operative complications in radical cystectomy for bladder transitional cell cancer: retrospective assessment from 208 consecutive cases].
abstract: OBJECTIVE
  To describe early complications (within 90 days) after radical cystectomy and to analyze the associated specific risk factors.
  
  
  METHODS
  The clinical data from 208 consecutive cases of muscle invasive bladder cancer were collected and reviewed. Potential variables predictive of early morbidity were retrospectively analyzed.
  
  
  RESULTS
  Of the 208 subjects, 160 (76.9%)developed at least 1 postoperative complication and 46 (22.2%) at least 2 complications. The most frequent complications presented were blood loss (75 cases), post-operative renal insufficiency (31 cases), and intestinal obstruction (29 cases). In univariate analysis, operative time, hypertension and preoperative creatinine level were associated with the development of complications. On multivariate analysis, operative time, preoperative creatinine level were the significant factors.
  
  
  CONCLUSIONS
  Morbidity remains high after radical cystectomy. The operative time, preoperative creatinine level and hypertension may be associated with the postoperative complications. Acknowledgement of the patients' specific risk factors and monitoring perioperative processes may incrementally reduce risks and improve outcomes of the patients.
authors.affiliation: Department of Urology, Peking University First Hospital; Institute of Urology,Peking University; National Urological Cancer Center, Beijing 100034, China.
authors.forename: Ying-wu
authors.initials: YW
authors.lastname: Wen
authors.forename: Ke-hui
authors.initials: KH
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Ying-lu
authors.initials: YL
authors.lastname: Guo
authors.forename: Qun
authors.initials: Q
authors.lastname: He
authors.forename: Zhi-jun
authors.initials: ZJ
authors.lastname: Xi
mesh_terms: D000368:Aged; D016063:Blood Loss, Surgical; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000601:surgery*; D003404:Creatinine / Q000097:blood; D015653:Cystectomy / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011183:Postoperative Complications / Q000453:epidemiology*; D051437:Renal Insufficiency / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*
chemical_list: D003404:Creatinine