title: Deregulated transcription factors in leukemia.
abstract: Specific chromosomal translocations and other mutations associated with acute myeloblastic leukemia (AML) often involve transcription factors and transcriptional coactivators. Such target genes include AML1, C/EBPα, RARα, MOZ, p300/CBP, and MLL, all of which are important in the regulation of hematopoiesis. The resultant fusion or mutant proteins deregulate the transcription of the affected genes and disrupt their essential role in hematopoiesis, causing differentiation block and abnormal proliferation and/or survival. This review focuses on such transcription factors and coactivators, and describes their roles in leukemogenesis and hematopoiesis.
authors.affiliation: Division of Hematological Malignancy, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shima
authors.affiliation: Division of Hematological Malignancy, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. ikitabay@ncc.go.jp.
authors.forename: Issay
authors.initials: I
authors.lastname: Kitabayashi
mesh_terms: D015973:Gene Expression Regulation, Leukemic; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D050505:Mutant Proteins; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D050505:Mutant Proteins; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors