title: Mammalian metallothionein in toxicology, cancer, and cancer chemotherapy.
abstract: The present paper centers on mammalian metallothionein 1 and 2 in relationship to cell and tissue injury beginning with its reaction with Cd²⁺ and then considering its role in the toxicology and chemotherapy of both metals and non-metal electrophiles and oxidants. Intertwined is a consideration of MTs role in tumor cell Zn²⁺ metabolism. The paper updates and expands on our recent review by Petering et al. (Met Ions Life Sci 5:353-398, 2009).
authors.affiliation: Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, USA.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Namdarghanbari
authors.forename: William
authors.initials: W
authors.lastname: Wobig
authors.forename: Susan
authors.initials: S
authors.lastname: Krezoski
authors.forename: Niloofar M
authors.initials: NM
authors.lastname: Tabatabai
authors.forename: David H
authors.initials: DH
authors.lastname: Petering
mesh_terms: D000818:Animals; D003603:Cytotoxins / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D008322:Mammals; D008668:Metallothionein / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D008670:Metals / Q000378:metabolism / Q000633:toxicity; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016877:Oxidants / Q000378:metabolism
chemical_list: D003603:Cytotoxins; D008670:Metals; D016877:Oxidants; D008668:Metallothionein