title: Small ruminant resistance against gastrointestinal nematodes: a case of Haemonchus contortus.
abstract: Gastrointestinal nematode (GIN) infections are a common constraint to small ruminant industry throughout the world, and among those, haemonchosis has its own significance. Control of GIN primarily relies on the use of anthelmintics, but this approach has become less reliable due to the development of resistance in GINs against commonly used anthelmintics and an increased consumer demand for environmentally friendly animal products. These issues have stimulated investigations to find alternative sustainable control strategies, which are less reliant on anthelmintic input. One of such strategies is breeding of small ruminants for their resistance to the GINs. The susceptibility and resistance of animals to GIN infections varies within and between breeds. Various parasitological, biochemical and immunological parameters are employed to evaluate natural resistance status of animals both in natural pasture and artificial infections. The immune mechanisms responsible for resistance are not completely understood, but it has a significant effect in inherited resistance. Relatively resistant or tolerant animals show better local and generalised immune response as compared to susceptible. Immune response against GINs is influenced by many physiological factors. Determination of specific genes linked with host resistance will provide a valuable approach to find out the molecular mechanism of host resistance to GINs. Resistance has been reported to reduce pasture contamination, which in turn reduces re-infection and thus the requirement of the frequent anthelmintic treatments. The efficiency of control can be increased through objective and accurate identification of genetically tolerant individuals by natural and artificial infections with GINs. Complete resistance is the ultimate solution, but this has generally been ignored as a commercial reality. This paper reviews the published reports on natural resistance in small ruminants and discusses the prospects of developing small ruminants, which could be resistant to GINs.
authors.affiliation: Department of Zoology, Government College University Faisalabad, Faisalabad, Pakistan. abubaker_79@yahoo.com
authors.forename: Hafiz A
authors.initials: HA
authors.lastname: Saddiqi
authors.forename: Abdul
authors.initials: A
authors.lastname: Jabbar
authors.forename: Muhammad
authors.initials: M
authors.lastname: Sarwar
authors.forename: Zafar
authors.initials: Z
authors.lastname: Iqbal
authors.forename: Ghulam
authors.initials: G
authors.lastname: Muhammad
authors.forename: Mahrun
authors.initials: M
authors.lastname: Nisa
authors.forename: Aasif
authors.initials: A
authors.lastname: Shahzad
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology / Q000627:therapeutic use; D060467:Disease Resistance / Q000235:genetics*; D005260:Female; D005767:Gastrointestinal Diseases / Q000276:immunology / Q000469:parasitology; D015511:Goat Diseases / Q000276:immunology / Q000469:parasitology; D006041:Goats; D006188:Haemonchiasis / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects / Q000276:immunology*; D007113:Immunity, Innate / Q000235:genetics; D007411:Intestinal Diseases, Parasitic / Q000276:immunology / Q000662:veterinary*; D008297:Male; D012418:Ruminants / Q000276:immunology / Q000469:parasitology; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000469:parasitology
chemical_list: D000969:Antinematodal Agents