title: Formation of C-C Bonds via Iridium-Catalyzed Hydrogenation and Transfer Hydrogenation.
abstract: The formation of C-C bonds via catalytic hydrogenation and transfer hydrogenation enables carbonyl and imine addition in the absence of stoichiometric organometallic reagents. In this review, iridium-catalyzed C-C bond-forming hydrogenations and transfer hydrogenations are surveyed. These processes encompass selective, atom-economic methods for the vinylation and allylation of carbonyl compounds and imines. Notably, under transfer hydrogenation conditions, alcohol dehydrogenation drives reductive generation of organoiridium nucleophiles, enabling carbonyl addition from the aldehyde or alcohol oxidation level. In the latter case, hydrogen exchange between alcohols and π-unsaturated reactants generates electrophile-nucleophile pairs en route to products of hydro-hydroxyalkylation, representing a direct method for the functionalization of carbinol C-H bonds.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station - A5300, Austin, TX 78712-0165, USA and Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford 1 3TA, UK.
authors.forename: John F
authors.initials: JF
authors.lastname: Bower
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische