title: Long-term treatment with standardized Ginkgo biloba extract (EGb 761) attenuates cognitive deficits and hippocampal neuron loss in a gerbil model of vascular dementia.
abstract: The standardized extract of Ginkgo biloba EGb 761 has been used to reduce cognitive dysfunction. The present study was designed to evaluate the effect of postischemic oral treatment with EGb 761 in a model of vascular dementia in gerbils. Daily oral posttreatment with EGb 761 led to a significant recovery of spatial memory assessed by the object location test, inhibited the decrease in plasma SOD activity and protected the hippocampal CA1 neurons, even when administered after the insult. These data provide further evidence for the therapeutic potential of EGb 761 in the treatment of vascular dementia.
authors.affiliation: Ipsen Innovation, 5, avenue du canada 91940 les Ulis, France.
authors.forename: Marie-Noelle
authors.initials: MN
authors.lastname: Rocher
authors.forename: Denis
authors.initials: D
authors.lastname: Carré
authors.forename: Brigitte
authors.initials: B
authors.lastname: Spinnewyn
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Schulz
authors.forename: Sylvie
authors.initials: S
authors.lastname: Delaflotte
authors.forename: Bernadette
authors.initials: B
authors.lastname: Pignol
authors.forename: Pierre-Etienne
authors.initials: PE
authors.lastname: Chabrier
authors.forename: Michel
authors.initials: M
authors.lastname: Auguet
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000097:blood / Q000150:complications / Q000188:drug therapy; D015140:Dementia, Vascular / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D005849:Gerbillinae; D020441:Ginkgo biloba; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000097:blood / Q000188:drug therapy*; D009410:Nerve Degeneration / Q000097:blood / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood; D000096983:Ginkgo Extract
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; D013482:Superoxide Dismutase; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract