title: Successful treatment of ulcerative colitis associated with hypereosinophilic syndrome/chronic eosinophilic leukemia.
abstract: A 23-year-old female was diagnosed as having simultaneous ulcerative colitis (UC) relapse and hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL) without FIP1L1-platelet-derived growth factor receptor alpha (PDGFRA) (F/P) fusion gene. Pathological findings of colon specimens were compatible with UC, however, focal severe infiltration of eosinophils was observed in the rectum, which is unusual in UC, suggesting eosinophil-mediated organ damage. Although imatinib mesylate (IM) is usually ineffective for the treatment of HES/CEL with negative-F/P fusion gene, in the present case it led to the remission of HES/CEL and UC at a higher drug dosage level (400 mg/day). That suggested the presence of unknown tyrosine kinase abnormalities not yet categorized.
authors.affiliation: Department of Internal Medicine, Social Insurance Chuo General Hospital, Japan.
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Awano
authors.forename: Tomiko
authors.initials: T
authors.lastname: Ryu
authors.forename: Naoki
authors.initials: N
authors.lastname: Yoshimura
authors.forename: Masakazu
authors.initials: M
authors.lastname: Takazoe
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Kitamura
authors.forename: Masanori
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D001549:Benzamides; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D000068877:Imatinib Mesylate; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate