title: Histology and outcomes of newly detected lung lesions in melanoma patients.
abstract: BACKGROUND
  Melanoma frequently metastasizes to the lung. Improved radiologic techniques may decrease the need for biopsy of such lesions. The aim of this study was to examine factors predictive of a positive biopsy of melanoma.
  
  
  METHODS
  Using the Memorial Sloan-Kettering Cancer Center melanoma database, all patients with melanoma who had undergone biopsy of a suspicious new lung lesion from 1996 to 2009 were identified. Age, date of diagnosis, histology, and stage were obtained. Chart review was carried out to obtain medical history, smoking status, radiological appearance, and histology of lung lesions biopsied.
  
  
  RESULTS
  Two hundred and twenty-nine patients were identified; median age was 63 years; 48% were never smokers; 27% had a prior nonmelanoma cancer; 88% of lung nodules were malignant: 69% melanoma, 19% other cancers. Among 113 patients undergoing positron emission tomography (PET), proportions of benign, melanoma, and nonmelanoma 2-[fluorine-18]fluoro-2-deoxy-D-glucose-avid nodules did not differ (P = 0.53). On multivariable analysis, >stage I melanoma, negative smoking history, multiple lung nodules, and no prior nonmelanoma cancer were significantly associated with a melanoma biopsy result rather than other cancer.
  
  
  CONCLUSIONS
  In this study, 31% of lung lesions were not melanoma. In the subset undergoing PET, this did not differentiate between benign and malignant lesions. Biopsy is mandated in melanoma patients with new lung nodules.
authors.affiliation: Departments of Medicine.
authors.forename: E C
authors.initials: EC
authors.lastname: Smyth
authors.affiliation: Departments of Epidemiology-Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hsu
authors.affiliation: Departments of Epidemiology-Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Panageas
authors.affiliation: Departments of Medicine. Electronic address: chapmanp@mskcc.org.
authors.forename: P B
authors.initials: PB
authors.lastname: Chapman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D016208:Databases, Factual; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000556:secondary*; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000401:mortality / Q000556:secondary*; D008875:Middle Aged; D049268:Positron-Emission Tomography; D016016:Proportional Hazards Models; D055815:Young Adult