title: Highly enantioselective intermolecular Stetter reactions of β-aryl acceptors: α-ketoester moiety as handle for activation and synthetic manipulations.
abstract: The use of β,γ-unsaturated-α-ketoesters in the intermolecular Stetter reaction furnishes 1,2,5-tricarbonyl compounds in high yield and excellent enantioselectivity. The α,δ-diketoesters generated using this methodology serve as useful synthetic building blocks via chemo- and diastereoselective transformations.
authors.affiliation: Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sánchez-Larios
authors.forename: Karen
authors.initials: K
authors.lastname: Thai
authors.forename: François
authors.initials: F
authors.lastname: Bilodeau
authors.forename: Michel
authors.initials: M
authors.lastname: Gravel
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D004952:Esters; D007659:Ketones