title: Brief report: Hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: a clinical trial.
abstract: We sought to determine whether HBOT leads to parental reported behavioral changes and alterations in cytokines in children with ASD. Ten children completed 80 sessions of HBOT and all improved by 2 points on the clinician-rated CGI-I scale (much improved) as well as several parent-completed measures of behavior. The lack of a control group limits the ability to determine if improvements were related to HBOT. Enrolled children did not exhibit abnormal cytokine levels at baseline and no significant changes in mean cytokine levels were observed. Although this study was limited by the small sample size and by the variable nature of cytokines, we found no evidence that HBOT affects cytokine levels or that cytokine levels were associated with behavioral changes.
authors.affiliation: Department of Psychiatry, University of California, San Francisco, CA, USA. Stephen.Bent@ucsf.edu
authors.forename: Stephen
authors.initials: S
authors.lastname: Bent
authors.forename: Kiah
authors.initials: K
authors.lastname: Bertoglio
authors.forename: Paul
authors.initials: P
authors.lastname: Ashwood
authors.forename: Edward
authors.initials: E
authors.lastname: Nemeth
authors.forename: Robert L
authors.initials: RL
authors.lastname: Hendren
mesh_terms: D002648:Child; D002659:Child Development Disorders, Pervasive / Q000628:therapy*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D016896:Treatment Outcome