title: Clinical significance of TRAIL and TRAIL receptors in patients with head and neck cancer.
abstract: BACKGROUND
  Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a death ligand currently under clinical trials for cancer. The molecular profile of TRAIL and TRAIL receptors has not yet been mapped for patients with laryngeal squamous cell carcinoma (SCC) or patients with oral cavity squamous cell carcinoma (OCSCC).
  
  
  METHODS
  Paraffin-embedded tissues from 60 patients with laryngeal SCC and 14 patients with OCSCC were retrospectively analyzed using immunohistochemistry.
  
  
  RESULTS
  An increase in decoy-R1 (DcR1) but a decrease in decoy-R2 (DcR2) expression were observed in patients with laryngeal SCC and in patients with OCSCC compared with control individuals with benign lesions. Clinical and pathologic grading revealed distinctive TRAIL and TRAIL receptor profiles in patients with squamous cell carcinoma of the head and neck (SCCHN).
  
  
  CONCLUSIONS
  TRAIL and a TRAIL receptor expression profile might be useful to follow-up disease progression by virtue of its connection with clinical staging and pathologic grading in patients with laryngeal SCC.
authors.affiliation: Human Gene Therapy Division of the Department of Medical Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkey.
authors.forename: Burcak
authors.initials: B
authors.lastname: Yoldas
authors.forename: Cem
authors.initials: C
authors.lastname: Ozer
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ozen
authors.forename: Tuba
authors.initials: T
authors.lastname: Canpolat
authors.forename: Isilay
authors.initials: I
authors.lastname: Dogan
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Griffith
authors.forename: Salih
authors.initials: S
authors.lastname: Sanlioglu
authors.forename: Levent N
authors.initials: LN
authors.lastname: Ozluoglu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism*; D012189:Retrospective Studies; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism*
chemical_list: D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand