title: Why do our kidneys get old?
abstract: The majority of the human population shows a decline in renal clearance with age and a loss of renal physiologic reserve. Kidneys are increasingly less able to deal with stressful challenges such as a salt or acid load. It is not clear what underlies this aging-related change and whether it is inevitable or can be modified in such a way as to preserve renal function throughout the life span. This is a very brief review of aging biology and how it might impact on renal aging.
authors.affiliation: Division of Geriatrics, Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. wiggi @ umich.edu
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Wiggins
mesh_terms: D000375:Aging / Q000235:genetics / Q000502:physiology*; D060833:Cellular Microenvironment / Q000235:genetics / Q000502:physiology*; D005966:Glucuronidase / Q000235:genetics; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D000090265:Klotho Proteins; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D037761:Sirtuins / Q000235:genetics; D058570:TOR Serine-Threonine Kinases / Q000235:genetics
chemical_list: D007334:Insulin-Like Growth Factor I; D058570:TOR Serine-Threonine Kinases; D005966:Glucuronidase; D000090265:Klotho Proteins; D037761:Sirtuins