title: The role of metabolic syndrome components and adipokines in insulin resistance in prepubertal children.
abstract: OBJECTIVE
  Insulin resistance has a central role in the pathophysiology of cardiovascular atherosclerotic disease. Adipose tissue is of capital importance in view of its production of adipokines. The present study aims to determine the association of metabolic syndrome components, which constitute risk factors for cardiovascular atherosclerotic disease, and leptin and adiponectin with insulin resistance in prepubertal children.
  
  
  METHODS
  We conducted a cross-sectional study involving 197 children. Of these, 112 children were obese, 36 were overweight and 49 had normal weight. The association of sex, waist circumference, Acanthosis nigricans, age, BMI Z-score, serum lipids, leptin and adipocytokines with insulin resistance [defined as the homeostatic model assessment for insulin resistance (HOMA-IR) index higher than or equal to 2.5] was investigated using logistic regression.
  
  
  RESULTS
  There was positive association of sex (female), age, BMI Z-score, triglycerides and leptin with insulin resistance (p<0.05).
  
  
  CONCLUSIONS
  Among the conventional components of metabolic syndrome, the role of BMI Z-score and triglycerides stands out in insulin resistance of prepubertal children. Sex (female), age and leptin also showed to be of major importance.
authors.affiliation: Department of Pediatrics, FCM, UERJ, Brazil. isamadeira@oi.com.br
authors.forename: Isabel Rey
authors.initials: IR
authors.lastname: Madeira
authors.forename: Maria Alice Neves
authors.initials: MA
authors.lastname: Bordallo
authors.forename: Cecilia Noronha Miranda
authors.initials: CN
authors.lastname: Carvalho
authors.forename: Fernanda Mussi
authors.initials: FM
authors.lastname: Gazolla
authors.forename: Flavio Moutinho
authors.initials: FM
authors.lastname: de Souza
authors.forename: Haroldo José
authors.initials: HJ
authors.lastname: de Matos
authors.forename: Marcos Antônio
authors.initials: MA
authors.lastname: Borges
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications / Q000503:physiopathology; D054392:Adipokines / Q000502:physiology*; D052242:Adiponectin / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001938:Brazil; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000502:physiology; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000503:physiopathology*; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D050177:Overweight / Q000150:complications / Q000503:physiopathology; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; D008055:Lipids