title: Microwave-assisted decarboxylative three-component coupling of a 2-oxoacetic acid, an amine, and an alkyne.
abstract: A novel and efficient microwave-assisted decarboxylative three-component coupling of a 2-oxoacetic acid, an amine, and an alkyne (OA(2)-coulpling) has been developed. This new multicomponent coupling constitutes an efficient approach for the synthesis of polysubstituted propargylamines in the presence of a catalytic amount of copper(I) catalyst.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
authors.forename: Huangdi
authors.initials: H
authors.lastname: Feng
authors.forename: Denis S
authors.initials: DS
authors.lastname: Ermolat'ev
authors.forename: Gonghua
authors.initials: G
authors.lastname: Song
authors.forename: Erik V
authors.initials: EV
authors.lastname: Van der Eycken