title: NeuroPedia: neuropeptide database and spectral library.
abstract: CONCLUSIONS
  Neuropeptides are essential for cell-cell communication in neurological and endocrine physiological processes in health and disease. While many neuropeptides have been identified in previous studies, the resulting data has not been structured to facilitate further analysis by tandem mass spectrometry (MS/MS), the main technology for high-throughput neuropeptide identification. Many neuropeptides are difficult to identify when searching MS/MS spectra against large protein databases because of their atypical lengths (e.g. shorter/longer than common tryptic peptides) and lack of tryptic residues to facilitate peptide ionization/fragmentation. NeuroPedia is a neuropeptide encyclopedia of peptide sequences (including genomic and taxonomic information) and spectral libraries of identified MS/MS spectra of homolog neuropeptides from multiple species. Searching neuropeptide MS/MS data against known NeuroPedia sequences will improve the sensitivity of database search tools. Moreover, the availability of neuropeptide spectral libraries will also enable the utilization of spectral library search tools, which are known to further improve the sensitivity of peptide identification. These will also reinforce the confidence in peptide identifications by enabling visual comparisons between new and previously identified neuropeptide MS/MS spectra.
  
  
  BACKGROUND
  http://proteomics.ucsd.edu/Software/NeuroPedia.html
  
  
  BACKGROUND
  bandeira@ucsd.edu
  
  
  BACKGROUND
  Supplementary materials are available at Bioinformatics online.
authors.affiliation: Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, California 92093-0744, USA.
authors.forename: Yoona
authors.initials: Y
authors.lastname: Kim
authors.forename: Steven
authors.initials: S
authors.lastname: Bark
authors.forename: Vivian
authors.initials: V
authors.lastname: Hook
authors.forename: Nuno
authors.initials: N
authors.lastname: Bandeira
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030562:Databases, Protein; D057166:High-Throughput Screening Assays; D006801:Humans; D020407:Internet; D013058:Mass Spectrometry / Q000379:methods; D009479:Neuropeptides; D019151:Peptide Library; D010455:Peptides / Q000032:analysis; D012680:Sensitivity and Specificity; D053719:Tandem Mass Spectrometry
chemical_list: D009479:Neuropeptides; D019151:Peptide Library; D010455:Peptides