title: Identification of the metabolites of baicalein in human plasma.
abstract: The metabolites of baicalein in human plasma were investigated after taking baicalein, which is one of the main bioactive flavones in Scutellaria baicalensis Georgi. Five metabolites (M1-M5) together with the parent drug baicalein (P) were detected and identified by the HPLC-diode-array detector (DAD) and LC-MS/MS methods. Among them, 7-methoxybaicalein 6-O-glucuronide (M5) is a new metabolite. Based on the results, the proposed metabolic pathway of baicalein in humans was inferred.
authors.affiliation: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Guo
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Qi-Fang
authors.initials: QF
authors.lastname: Wang
authors.forename: Qi-Shi
authors.initials: QS
authors.lastname: Sun
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Che
authors.forename: Qing-Ming
authors.initials: QM
authors.lastname: Che
mesh_terms: D002851:Chromatography, High Pressure Liquid; D044950:Flavanones / Q000032:analysis / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D020719:Glucuronides / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D015394:Molecular Structure; D031364:Scutellaria baicalensis / Q000737:chemistry*
chemical_list: C561687:7-methoxybaicalein 6-O-glucuronide; D044950:Flavanones; D020719:Glucuronides; C006680:baicalein