title: Diabetes mellitus and risk of stroke and its subtypes among Japanese: the Japan public health center study.
abstract: OBJECTIVE
  Although diabetes mellitus has been recognized as a risk factor for ischemic stroke, evidence is limited for ischemic stroke subtypes among Asians.
  
  
  METHODS
  A survey was conducted of a total of 13 129 men and 22 528 women aged 40 to 69 years at baseline. During the median 12.0-year follow-up, there were 526 incidences of ischemic strokes (259 lacunar infarctions, 91 large-artery occlusive, and 140 embolic infarctions).
  
  
  RESULTS
  The risk of ischemic stroke for both sexes was approximately 2 to 4 times higher for diabetic subjects than for those with normal glucose levels. Significant excess risks of lacunar and embolic infarction for both sexes and of large-artery occlusive infarctions for women were also observed in diabetic subjects. Diabetes mellitus was not associated with risk of intraparenchymal or subarachnoid hemorrhage for either sex.
  
  
  CONCLUSIONS
  Diabetes mellitus is a significant risk factor for ischemic stroke and all subtypes of ischemic stroke for middle-aged Japanese.
authors.affiliation: Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan, 2-2 Yamadaoka, Suita-shi, Osaka, 565-0871 Japan.
authors.forename: Renzhe
authors.initials: R
authors.lastname: Cui
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.forename: Isao
authors.initials: I
authors.lastname: Saito
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kokubo
authors.forename: Manami
authors.initials: M
authors.lastname: Inoue
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D020520:Brain Infarction / Q000097:blood / Q000145:classification / Q000453:epidemiology* / Q000209:etiology; D003625:Data Collection; D048909:Diabetes Complications / Q000097:blood / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000145:classification / Q000453:epidemiology* / Q000209:etiology
chemical_list: D001786:Blood Glucose