title: Preventive effects of dentifrice containing 5000ppm fluoride against dental erosion in situ.
abstract: OBJECTIVE
  To evaluate the effectiveness of a dentifrice with 5000ppm fluoride in preventing dental erosion by orange juice in situ in comparison to a control dentifrice with 1450ppm fluoride.
  
  
  METHODS
  This was a double-blind and randomized clinical study with a cross-over design. Sixteen subjects wore an intra-oral appliance containing two enamel disks with an exposed surface of approximately 2mm×5mm. Enamel disks in the study group were treated with a dentifrice with 5000ppm fluoride and in the control group with 1450ppm fluoride. The subjects rinsed with slurries of study dentifrices for one minute before immersing the enamel disks in 250ml orange Juice four times in an 8-h period daily. The treatment procedure was repeated for three 5-day phases for each dentifrice. Enamel erosion was measured after each 5-day treatment phase using a focus-variation 3D scanning microscopy. Medians and inter-quartile ranges (IQR) of mean erosion depth were compared between the groups.
  
  
  RESULTS
  The mean erosion depths of enamel varied greatly amongst the subjects. Enamel treated with 5000ppm fluoride had less erosion (median 5.7μm, IQR 4.5μm) as compared to the control (median 12.6μm, IQR 12.3μm) after 15 days of fluoride treatment and erosive challenge cycles (p<0.05).
  
  
  CONCLUSIONS
  Enamel treated with 5000ppm fluoride had significantly improved resistance to erosion by orange juice. Periodic application of 5000ppm fluoride may be beneficial in individuals at risk of acidic erosion associated with soft drink consumptions.
authors.affiliation: University of Rochester Eastman Institute for Oral Health, Rochester, New York 14620, USA. yanfang_ren@urmc.rochester.edu
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Ren
authors.forename: Xuejun
authors.initials: X
authors.lastname: Liu
authors.forename: Noura
authors.initials: N
authors.lastname: Fadel
authors.forename: Hans
authors.initials: H
authors.lastname: Malmstrom
authors.forename: Virginia
authors.initials: V
authors.lastname: Barnes
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
mesh_terms: D000328:Adult; D001628:Beverages / Q000009:adverse effects*; D032084:Citrus sinensis / Q000009:adverse effects; D018592:Cross-Over Studies; D003802:Dentifrices / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012969:Sodium Fluoride / Q000008:administration & dosage*; D018709:Statistics, Nonparametric; D014077:Tooth Erosion / Q000209:etiology / Q000517:prevention & control*
chemical_list: D003802:Dentifrices; D012969:Sodium Fluoride