title: Total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate.
abstract: We report the first total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate. Our route features a number of key transformations, including an indolyne cyclization to assemble the [4.3.1]-bicyclic scaffold, as well as a late-stage intramolecular nitrene insertion to functionalize the C11 bridgehead carbon en route to the natural product.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Huters
authors.forename: Kyle W
authors.initials: KW
authors.lastname: Quasdorf
authors.forename: Evan D
authors.initials: ED
authors.lastname: Styduhar
authors.forename: Neil K
authors.initials: NK
authors.lastname: Garg
mesh_terms: D060326:Chemistry Techniques, Synthetic; D000458:Cyanobacteria / Q000737:chemistry*; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D026121:Indole Alkaloids; D007211:Indoles; C092268:N-methylwelwitindolinone C isothiocyanate