title: The evidence doesn't justify steps by state Medicaid programs to restrict opioid addiction treatment with buprenorphine.
abstract: Many state Medicaid programs restrict access to buprenorphine, a prescription medication that relieves withdrawal symptoms for people addicted to heroin or other opiates. The reason is that officials fear that the drug is costlier or less safe than other therapies such as methadone. To find out if this is true, we compared spending, the use of services related to drug-use relapses, and mortality for 33,923 Massachusetts Medicaid beneficiaries receiving either buprenorphine, methadone, drug-free treatment, or no treatment during the period 2003-07. Buprenorphine appears to have significantly expanded access to treatment because the drug can be prescribed by a physician and taken at home compared with methadone, which by law must be administered at an approved clinic. Buprenorphine was associated with more relapse-related services but $1,330 lower mean annual spending than methadone when used for maintenance treatment. Mortality rates were similar for buprenorphine and methadone. By contrast, mortality rates were 75 percent higher among those receiving drug-free treatment, and more than twice as high among those receiving no treatment, compared to those receiving buprenorphine. The evidence does not support rationing buprenorphine to save money or ensure safety.
authors.affiliation: University of Massachusetts Medical School, Worcester, MA, USA. robin.clark@umassmed.edu
authors.forename: Robin E
authors.initials: RE
authors.lastname: Clark
authors.forename: Mihail
authors.initials: M
authors.lastname: Samnaliev
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Baxter
authors.forename: Gary Y
authors.initials: GY
authors.lastname: Leung
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000009:adverse effects; D002047:Buprenorphine / Q000009:adverse effects / Q000191:economics* / Q000627:therapeutic use; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007345:Insurance Claim Review; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008484:Medicaid; D008875:Middle Aged; D058850:Opiate Substitution Treatment / Q000009:adverse effects / Q000191:economics*; D009293:Opioid-Related Disorders / Q000401:mortality / Q000534:rehabilitation*; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine