title: Evaluation of patients' preferences for genital herpes treatment.
abstract: BACKGROUND
  Genital herpes (GH) is widespread, and detrimental to patients' quality of life. It is not always adequately treated, however, with potential consequences for patients' well-being and healthcare costs. Involving patients in treatment decisions can increase their satisfaction and adherence. We investigated patients' preferences for different GH treatments.
  
  
  METHODS
  A discrete choice experiment was administered to 154 subjects with GH. Subjects chose between different treatment options: episodic, suppressive, or no treatment, described according to: chance of GH recurrence; chance of transmitting the GH virus to a partner; chance of becoming infected with HIV; number of tablets to be taken every day and during an outbreak; and out-of-pocket cost. Subjects' willingness to pay and probability of treatment uptake were estimated.
  
  
  RESULTS
  Subjects preferred antiviral treatment to no treatment, and subjects receiving suppressive treatment preferred this treatment to no treatment. Effect of treatment on GH recurrence and HIV infection rates was a significant influence on subject's choice, as were the number of tablets taken daily and during an outbreak and out-of pocket treatment cost. Subjects were willing to pay between $15.50 and $73.41 for treatment. Subjects' willingness to pay depends on the type of treatment and their current treatment.
  
  
  CONCLUSIONS
  Subjects' preferences are influenced by both the treatment they follow and attributes of treatment including cost. Knowledge of patients' preferences, together with their clinical status, could help decision-makers to optimize therapy uptake and success.
authors.affiliation: Research Centre On Public Health, Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Italy. luciana.scalone@unimib.it
authors.forename: Luciana
authors.initials: L
authors.lastname: Scalone
authors.forename: Verity
authors.initials: V
authors.lastname: Watson
authors.forename: Mandy
authors.initials: M
authors.lastname: Ryan
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kotsopoulos
authors.forename: Rajul
authors.initials: R
authors.lastname: Patel
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000191:economics; D002755:Choice Behavior; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology; D017048:Health Care Costs; D007722:Health Knowledge, Attitudes, Practice; D006558:Herpes Genitalis / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D057240:Patient Preference / Q000706:statistics & numerical data*; D017060:Patient Satisfaction; D011788:Quality of Life; D012008:Recurrence; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D006113:United Kingdom; D014481:United States; D055815:Young Adult
chemical_list: D000998:Antiviral Agents