title: Antifungal activity of denture soft lining material modified by silver nanoparticles-a pilot study.
abstract: Soft liner materials in oral cavity environments are easily colonized both by fungi and dental plaque. These factors are the cause of mucosal infections. The microorganism that most frequently colonizes soft liner materials is Candida albicans. Colonization occurs on the surface of materials and within materials. A solution to this problem might involve modification of soft liner materials with silver nanoparticles (AgNPs). In this article, we present results showing the antifungal efficacy of silicone soft lining materials modified with AgNPs. The modification process was conducted by dissolving both material components (base and catalyst) in a colloidal solution of AgNPs and evaporating the solvent. Composites with various AgNP concentrations (10, 20, 40, 80, 120 and 200 ppm) were examined. The in vitro antifungal efficacy (AFE) of composite samples was 16.3% to 52.5%.
authors.affiliation: Department of Materials Technology, Silesian University of Technology, ul. Krasińskiego 8, 40-019 Katowice, Poland; E-Mail: Jaroslaw.Zmudzki@polsl.pl.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Chladek
authors.forename: Anna
authors.initials: A
authors.lastname: Mertas
authors.forename: Izabela
authors.initials: I
authors.lastname: Barszczewska-Rybarek
authors.forename: Teresa
authors.initials: T
authors.lastname: Nalewajek
authors.forename: Jarosław
authors.initials: J
authors.lastname: Zmudzki
authors.forename: Wojciech
authors.initials: W
authors.lastname: Król
authors.forename: Jan
authors.initials: J
authors.lastname: Lukaszczyk
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D003764:Dental Materials / Q000737:chemistry* / Q000494:pharmacology*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010865:Pilot Projects; D012828:Silicones / Q000737:chemistry; D012834:Silver / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D003764:Dental Materials; D012828:Silicones; D012834:Silver