title: PEGylated anti-MUC1 aptamer-doxorubicin complex for targeted drug delivery to MCF7 breast cancer cells.
abstract: Targeted drug delivery is especially important in cancer treatment as many anti-cancer drugs are non-specific and highly toxic to both cancer and normal cells. The targeted drug delivery of DOX to the MUC1-expressing breast cancer cell line (MCF7) was obtained using APT as a carrier. Modification of the APT-DOX complex by PEG increases the survivability of the macrophage control (RAW 264.7) by about six-fold as compared to free DOX treatment without significantly affecting the cytotoxicity toward the target cell line. Thus, PEG-APT-DOX is potentially a new therapeutic agent for targeted drug delivery to MUC1-expressing cell lines.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, 119260, Singapore.
authors.forename: Lihan
authors.initials: L
authors.lastname: Tan
authors.forename: Koon Gee
authors.initials: KG
authors.lastname: Neoh
authors.forename: En-Tang
authors.initials: ET
authors.lastname: Kang
authors.forename: Woo Seok
authors.initials: WS
authors.lastname: Choe
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Su
mesh_terms: D000818:Animals; D052158:Aptamers, Peptide / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods*; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D051379:Mice; D018396:Mucin-1 / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D052158:Aptamers, Peptide; D018396:Mucin-1; D011092:Polyethylene Glycols; D004317:Doxorubicin