title: Clinical significance of intestinal type fatty acid binding protein in patients undergoing coronary artery bypass surgery.
abstract: OBJECTIVE
  The aim of this study was to determine whether serum levels of intestinal type fatty acid binding protein (I-FABP) are related to intestinal ischemia in patients undergoing coronary bypass surgery.
  
  
  METHODS
  The study was planned as prospective, observational. Elective coronary artery bypass candidate patients between ages of 50 and 70 were consecutively included in the study. Thirty-five patients scheduled for cardiopulmonary bypass (CPB) were identified as the CPB group and 16 patients not scheduled for CPB were identified as the off-pump coronary artery bypass surgery (OPCAB) group. The variables between and within the groups were analyzed with Student's t, Mann-Whitney U, Friedman and Wilcoxon tests respectively.
  
  
  RESULTS
  In both CPB and OPCAB groups, I-FABP level at the end of the operation was significantly higher than that noted at the beginning of the operation (p<0.005). In the CPB group, there was a significant drop in I-FABP from the end of the operation to each of the postoperative time points (12(th) hour and 24(th) hour) (respectively p<0.001, p<0.001). In the OPCAB group, the I-FABP levels at both postoperative time points were lower than that at the end of the operation (p<0.001), and the level at 24-hour post-surgery was significantly lower than at both the end-of-operation I-FABP value (p<0.001) and the 12-hour post-surgery I-FABP value.
  
  
  CONCLUSIONS
  Since we have not observed any intestinal ischemia through our research, slight changes of I-FABP measurements make us believe that I-FABP would be a valuable way to monitor for intestinal ischemia in patients who undergo cardiac surgery.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Başkent University, Ankara, Turkey. acamkiran@gmail.com
authors.forename: Aynur
authors.initials: A
authors.lastname: Camkıran
authors.forename: Aslı
authors.initials: A
authors.lastname: Dönmez
authors.forename: Derya
authors.initials: D
authors.lastname: Aldemir
authors.forename: Rauf Agah
authors.initials: RA
authors.lastname: Işgüzar
authors.forename: Bahadır
authors.initials: B
authors.lastname: Gültekin
mesh_terms: D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000601:surgery*; D011183:Postoperative Complications / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D050556:Fatty Acid-Binding Proteins