title: MEMO associated with an ErbB2 receptor phosphopeptide reveals a new phosphotyrosine motif.
abstract: Tyrosine phosphorylations are essential in signal transduction. Recently, a new type of phosphotyrosine binding protein, MEMO (Mediator of ErbB2-driven cell motility), has been reported to bind specifically to an ErbB2-derived phosphorylated peptide encompassing Tyr-1227 (PYD). Structural and functional analyses of variants of this peptide revealed the minimum sequence required for MEMO recognition. Using a docking approach we have generated a structural model for MEMO/PYD complex and compare this new phosphotyrosine motif to SH2 and PTB phosphotyrosine motives.
authors.affiliation: UPR3243-CNRS, Marseille, France.
authors.forename: Mikaël
authors.initials: M
authors.lastname: Feracci
authors.forename: Cyril
authors.initials: C
authors.lastname: Pimentel
authors.forename: Olivier
authors.initials: O
authors.lastname: Bornet
authors.forename: Philippe
authors.initials: P
authors.lastname: Roche
authors.forename: Danièle
authors.initials: D
authors.lastname: Salaun
authors.forename: Ali
authors.initials: A
authors.lastname: Badache
authors.forename: Françoise
authors.initials: F
authors.lastname: Guerlesquin
mesh_terms: D020816:Amino Acid Motifs; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D019159:Nonheme Iron Proteins / Q000378:metabolism*; D010748:Phosphopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D019000:Phosphotyrosine / Q000737:chemistry*; D011485:Protein Binding; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D019159:Nonheme Iron Proteins; D010748:Phosphopeptides; D019000:Phosphotyrosine; D018719:Erb-b2 Receptor Tyrosine Kinases; C527585:MEMO1 protein, human; C508053:ERBB2 protein, human