title: Colonic in situ mantle cell lymphoma.
abstract: This report describes the first case, to our knowledge, of in situ mantle cell lymphoma (MCL) in the gastrointestinal tract identified retrospectively by immunostains and fluorescence in situ hybridization (FISH) analysis after progression to disseminated disease with pleomorphic morphology several years later. A 45-year-old man with blood per rectum underwent colonoscopy and had random biopsies interpreted as benign colonic mucosa. Two years later, he presented with ileocolic intussusception related to enlarged lymph nodes. Biopsies on the second presentation demonstrated widespread MCL. Reevaluation of the original colonic biopsies showed cyclin D1-positive cells within small lymphoid aggregates, confirmed by FISH for t(11;14). Postchemotherapy, lymphoid aggregates in colonic biopsies showed scattered cyclin D1- and FISH t(11;14)-positive cells, similar to the original in situ lymphoma. We discuss this case in the context of the current understanding of the evolution of MCL and the difficulties associated with detecting primary GI lymphoma.
authors.affiliation: Department of Pathology and Laboratory Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA.
authors.forename: Antonio G
authors.initials: AG
authors.lastname: Neto
authors.forename: Gabor
authors.initials: G
authors.lastname: Oroszi
authors.forename: Petr
authors.initials: P
authors.lastname: Protiva
authors.forename: Michal
authors.initials: M
authors.lastname: Rose
authors.forename: Nelofar
authors.initials: N
authors.lastname: Shafi
authors.forename: Richard
authors.initials: R
authors.lastname: Torres
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001706:Biopsy; D002278:Carcinoma in Situ / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D003113:Colonoscopy; D019938:Cyclin D1 / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007413:Intestinal Mucosa / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; D019938:Cyclin D1