title: Protons and Ca2+: ionic allies in tumor progression?
abstract: Ion channels and G-protein-coupled receptors (GPCRs) play a fundamental role in cancer progression by influencing Ca(2+) influx and signaling pathways in transformed cells. Transformed cells thrive in a hostile environment that is characterized by extracellular acidosis that promotes the pathological phenotype. The pathway(s) by which extracellular protons achieve this remain unclear. Here, a role for proton-sensing ion channels and GPCRs as mediators of the effects of extracellular protons in cancer cells is discussed.
authors.affiliation: Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, United Kingdom. maike.glitsch@dpag.ox.ac.uk
authors.forename: Maike
authors.initials: M
authors.lastname: Glitsch
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D018450:Disease Progression; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011522:Protons; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D011522:Protons; D043562:Receptors, G-Protein-Coupled; D006859:Hydrogen; D002118:Calcium