title: [Intravascular lymphoma: report of two autopsic cases, literature review].
abstract: Intravacular large B-cell lymphoma (LIV) is a rare entity individualized in the WHO classification since 2001 as a subtype of extranodal diffuse large B-cell lymphoma. We report two autopsic cases of LIV: a 77-year-old woman presenting with fever, dyspnea, antehypophyseal failure and a 54-year-old man presenting with fever, weight-loss, night-sweats and encephalopathy. They died respectively 10 and 7 months after the beginning of symptoms, without diagnosis. Neither infectious disease nor lymphomatous proliferation had been identified. From these two cases and our literature review, we insist on the importance of histopathological diagnosis on biopsy for this rare pathology which clinical diagnosis remains difficult.
authors.affiliation: Service d'anatomie et cytologie pathologiques, hôpital Bretonneau, CHRU de Tours, 37044 Tours cedex 9, France. c.rousselot@chu-tours.fr
authors.forename: Cécilia
authors.initials: C
authors.lastname: Rousselot-Denis
authors.forename: Flavie
authors.initials: F
authors.lastname: Arbion
authors.forename: Maud
authors.initials: M
authors.lastname: Jaunas
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Rousselet
authors.forename: Serge
authors.initials: S
authors.lastname: Guyetant
mesh_terms: D000368:Aged; D001247:Asthenia / Q000209:etiology; D001344:Autopsy; D001921:Brain / Q000098:blood supply / Q000473:pathology; D003244:Consciousness Disorders / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D005334:Fever / Q000209:etiology; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology; D016130:Immunophenotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000502:physiology; D010179:Pancreas / Q000098:blood supply / Q000473:pathology; D013163:Splenomegaly / Q000209:etiology; D019043:Vascular Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*
chemical_list: D009363:Neoplasm Proteins