title: Coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma: the influence of lymph node metastasis.
abstract: BACKGROUND
  The aim of this study was to evaluate the influence of coexistent Hashimoto's thyroiditis with papillary thyroid carcinoma on lymph node metastasis.
  
  
  METHODS
  The coexistent Hashimoto's thyroiditis group was defined by the presence of thyroid autoantibodies or pathologic confirmation. The control group did not have autoantibodies, disease, or ultrasound findings of Hashimoto's thyroiditis.
  
  
  RESULTS
  For the Hashimoto's thyroiditis group, only central lymph node metastasis had a lower frequency and the mean number of central metastatic lymph nodes was lower than in the control group after adjustment. With regard to lateral lymph node involvement, there was no significant difference between the 2 groups. The multivariate analysis showed a negative association between the coexistence of Hashimoto's thyroiditis and central lymph node metastasis.
  
  
  CONCLUSIONS
  Coexisting Hashimoto's thyroiditis in patients with papillary thyroid carcinoma was identified as a negative independent predictive factor for central lymph node metastasis.
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Byung Joo
authors.initials: BJ
authors.lastname: Lee
authors.forename: Jin Choon
authors.initials: JC
authors.lastname: Lee
authors.forename: Seong-Jang
authors.initials: SJ
authors.lastname: Kim
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Jeon
authors.forename: Mi Ra
authors.initials: MR
authors.lastname: Kim
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Huh
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Mok
authors.forename: Bo Hyun
authors.initials: BH
authors.lastname: Kim
authors.forename: Yong Ki
authors.initials: YK
authors.lastname: Kim
authors.forename: In Joo
authors.initials: IJ
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000150:complications* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D050031:Hashimoto Disease / Q000150:complications*; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology; D055815:Young Adult