title: Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.
abstract: TORC1-dependent phosphorylation of Saccharomyces cerevisiae Sch9 was dramatically reduced upon exposure to a protonophore or in respiration-incompetent ρ(0) cells but not in respiration-incompetent pet mutants, providing important insight into the molecular mechanisms governing interorganellar signaling in general and retrograde signaling in particular.
authors.affiliation: Laboratory of Basic and Applied Molecular Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan. kawais@kais.kyoto-u.ac.jp
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kawai
authors.forename: Jörg
authors.initials: J
authors.lastname: Urban
authors.forename: Manuele
authors.initials: M
authors.lastname: Piccolis
authors.forename: Nicolas
authors.initials: N
authors.lastname: Panchaud
authors.forename: Claudio
authors.initials: C
authors.lastname: De Virgilio
authors.forename: Robbie
authors.initials: R
authors.lastname: Loewith
mesh_terms: D015966:Gene Expression Regulation, Fungal; D054629:Genome, Mitochondrial; D008928:Mitochondria / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029701:Saccharomyces cerevisiae Proteins; C561842:TORC1 protein complex, S cerevisiae; D014157:Transcription Factors; D017346:Protein Serine-Threonine Kinases; C530964:SCH9 protein, S cerevisiae