title: Relevance of Bifidobacterium animalis subsp. lactis plasminogen binding activity in the human gastrointestinal microenvironment.
abstract: Human plasmin(ogen) is regarded as a component of the molecular cross talk between the probiotic species Bifidobacterium animalis subsp. lactis and the human host. However, up to now, only in vitro studies have been reported. Here, we demonstrate that the probiotic strain B. animalis subsp. lactis BI07 is capable of recruiting plasmin(ogen) present at physiological concentrations in crude extracts from human feces. Our results provide evidence that supports the significance of the B. lactis-plasmin(ogen) interaction in the human gastrointestinal tract.
authors.affiliation: Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro n.6, Bologna, Italy. marco.candela@unibo.it
authors.forename: Marco
authors.initials: M
authors.lastname: Candela
authors.forename: Silvia
authors.initials: S
authors.lastname: Turroni
authors.forename: Manuela
authors.initials: M
authors.lastname: Centanni
authors.forename: Jessica
authors.initials: J
authors.lastname: Fiori
authors.forename: Simone
authors.initials: S
authors.lastname: Bergmann
authors.forename: Sven
authors.initials: S
authors.lastname: Hammerschmidt
authors.forename: Patrizia
authors.initials: P
authors.lastname: Brigidi
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D001644:Bifidobacterium / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism*; D005243:Feces / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D010958:Plasminogen / Q000378:metabolism*; D019936:Probiotics
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; C084529:plasminogen-binding protein, bacteria; D010958:Plasminogen