title: Non-healing leg ulcers in a patient with dystrophic calcification and crest syndrome: a challenging clinical case.
abstract: The management of non-healing leg ulcers in patients with CREST syndrome and subdermal calcification is rarely reported in medical literature. Only one similar case was found in the literature (1). Dealing with such patients can be a challenge for wound specialists. In this article, we discuss the clinical progress of an interesting case of extensive non-healing leg ulcers in a CREST patient with dystrophic calcification. The combination of systemic physiological deficits and immune compromise, along with the local physical abnormalities associated with the wound pose a complex multifactorial aetiological mix. There is no conclusive data on the optimal management of these wounds in CREST patients. It seems that ablation of the calcific deposits may offer some hope.
authors.affiliation: Department of Vascular Surgery, Gold Coast Hospital, Southport, Queensland, Australia.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Al-Najjar
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Jackson
mesh_terms: D000368:Aged; D001458:Bandages; D017675:CREST Syndrome / Q000150:complications*; D002114:Calcinosis / Q000150:complications*; D003078:Colchicine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007871:Leg Ulcer / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D018810:Magnetic Resonance Angiography; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014945:Wound Healing
chemical_list: D003078:Colchicine