title: Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion.
abstract: Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH(4)) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49 mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH(4). PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion.
authors.affiliation: Division of Nano & Bio Technology, Daegu Gyungbuk Institute of Science & Technology, Daegu, Republic of Korea.
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Lee
authors.forename: Se Guen
authors.initials: SG
authors.lastname: Lee
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Oh
authors.forename: Ho Yun
authors.initials: HY
authors.lastname: Chung
authors.forename: Sang Ik
authors.initials: SI
authors.lastname: Han
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Kim
authors.forename: Song Yi
authors.initials: SY
authors.lastname: Seo
authors.forename: Han Do
authors.initials: HD
authors.lastname: Ghim
authors.forename: Jeong Hyun
authors.initials: JH
authors.lastname: Yeum
authors.forename: Jin Hyun
authors.initials: JH
authors.lastname: Choi
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003102:Colloids / Q000737:chemistry*; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D053768:Metal Nanoparticles / Q000009:adverse effects / Q000737:chemistry*; D011094:Polyethyleneimine / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D003102:Colloids; D012834:Silver; D011094:Polyethyleneimine