title: Acute kidney injury in the elderly: predisposition to chronic kidney disease and vice versa.
abstract: There have been considerable advances in the past few years in our understanding of how chronic kidney disease (CKD) predisposes to acute kidney injury (AKI) and vice versa. This review shows, however, that few studies have focused on the elderly or conducted stratified analysis by age. It does appear that elderly patients with estimated glomerular filtration rate (eGFR) 45-59 ml/min/1.73 m(2) are at higher risk for AKI compared with their counterparts with eGFR >60 ml/min/1.73 m(2). This is a similar relationship to that seen in younger patients, although effect size appears smaller. As the incidence of AKI has been increasing over the past several years, the proportion of elderly patients surviving after AKI has also been increasing. Since AKI heightens the risk for the development and acceleration of CKD, this implies significant public health concerns with regard to the absolute number of elderly persons developing incident CKD.
authors.affiliation: Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Coca
authors.forename: Kerry C
authors.initials: KC
authors.lastname: Cho
authors.forename: Chi-yuan
authors.initials: CY
authors.lastname: Hsu
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000209:etiology; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D006328:Cardiac Catheterization / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015331:Cohort Studies; D048909:Diabetes Complications / Q000453:epidemiology; D018450:Disease Progression; D004198:Disease Susceptibility; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000209:etiology; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000453:epidemiology*; D011157:Population Dynamics; D015995:Prevalence; D012307:Risk Factors; D014481:United States / Q000453:epidemiology