title: Tumor-induced osteomalacia: The tumor may stay hidden!
abstract: We report the case of a patient with severe muscular and articular tenderness that caused almost complete immobility. This subject had severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth factor 23 (FGF-23) was abnormally high and the diagnostic of tumor-induced osteomalacia was made. Despite multiple tests, the tumor was not localized. In this report, we discuss different possible investigations to localize the tumor. Lastly, we review the potential therapy available when tumor is not found and can thus not be excised.
authors.affiliation: Department of Nuclear Medicine, University of Liège, CHU Sart Tilman, Liège, Belgium. catherinevanderrest@hotmail.com
authors.forename: Catherine
authors.initials: C
authors.lastname: van der Rest
authors.forename: Etienne
authors.initials: E
authors.lastname: Cavalier
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Kaux
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Krzesinski
authors.forename: Roland
authors.initials: R
authors.lastname: Hustinx
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Reginster
authors.forename: Pierre
authors.initials: P
authors.lastname: Delanaye
mesh_terms: D015519:Bone Density; D002118:Calcium / Q000627:therapeutic use; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood; D006801:Humans; D017674:Hypophosphatemia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000175:diagnosis*; D010018:Osteomalacia / Q000188:drug therapy* / Q000209:etiology*; D010710:Phosphates / Q000627:therapeutic use; D049268:Positron-Emission Tomography; D016896:Treatment Outcome; D014807:Vitamin D / Q000627:therapeutic use; D051598:Whole Body Imaging
chemical_list: C000717427:FGF23 protein, human; D010710:Phosphates; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002118:Calcium