title: Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality.
abstract: Fibroblast growth factor receptor 2 (FGFR2), a recently described risk factor for breast cancer, plays important roles in cell growth, invasiveness, motility, and angiogenesis. In attempt to investigate whether FGFR2 polymorphisms are associated with a risk of breast cancer in Chinese women of the Han nationality, we genotyped single-nucleotide polymorphisms (SNPs) of seven FGFR2 sites (rs2981582, rs17102287, rs17542768, rs10510097, rs11200012, rs3750817, rs2981578) in 816 women including 388 breast cancer patients and 428 healthy controls via the polymerase chain reaction single-strand conformation polymorphism procedure as well as sequence detection. Our results suggest that the A allele and AA genotype of SNP rs2981578 appear to be protective factors associated with breast cancer, while the CT genotype of SNP rs3750817 is a putative risk factor.
authors.affiliation: Life Sciences School of Hubei University, 368 Youyi Road, Wuchang, Wuhan 430062, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Chen
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.forename: Min
authors.initials: M
authors.lastname: Lv
authors.forename: Yun
authors.initials: Y
authors.lastname: Xue
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Feifei
authors.initials: F
authors.lastname: Hu
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Zhanqin
authors.initials: Z
authors.lastname: Zhao
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: XingGuo
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
chemical_list: C496353:FGFR2 protein, human; D051497:Receptor, Fibroblast Growth Factor, Type 2