title: Chromosomal abnormalities in patients with recurrent spontaneous abortions in northeast China.
abstract: OBJECTIVE
  To investigate the ratio and types of chromosomal abnormalities in patients with recurrent spontaneous abortions (RSAs).
  
  
  METHODS
  In this study, cytogenetic results of 734 patients with RSA, 360 men and 374 women, were referred to Norman Bethune Medicine College, Jilin University, Changchun, China, from May 2004 to December 2009. Among these 734 patients, 172 were couples. Gbanded cytogenetic analysis was performed based on our standard laboratory protocols, and results were given based on International System for Human Cytogenetic Nomenclature 2005 and 2009.
  
  
  RESULTS
  Of the total 734 patients, 22 patients were found to have abnormal karyotypes, which were believed to cause RSA. Eight of them were men (1.09%) and 14 were women (1.91%). The chromosomal abnormalities detected include reciprocal translocation (2.45%), dicentric abnormality (0.14%), Robertsonian translocation (0.27%), and inversion (0.14%).
  
  
  CONCLUSIONS
  Chromosomal abnormality is an important cause of RSA. It is very important to provide chromosomal analysis service for patients with RSA, and it should be considered as a standard medical care.
authors.affiliation: Center for Reproductive Medicine of the First Hospital, Jilin University, Changchun, People's Republic of China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Heli
authors.initials: H
authors.lastname: Gao
authors.forename: Shibo
authors.initials: S
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Hong
authors.forename: Ruizhi
authors.initials: R
authors.lastname: Liu
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D002681:China / Q000453:epidemiology; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D025063:Chromosome Disorders / Q000453:epidemiology / Q000235:genetics*; D007446:Chromosome Inversion / Q000235:genetics; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult