title: Co-existence of gastrointestinal stromal tumors with other primary neoplasms.
abstract: OBJECTIVE
  Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal neoplasms of the tubular gastrointestinal tract (GI). Here, we present a series of 32 patients diagnosed with a primary neoplasm in addition to GIST, from six different institutions in Turkey.
  
  
  METHODS
  In total, 200 patients with GIST were evaluated; 32 patients with both GISTs and other primary malignancies were identified.
  
  
  RESULTS
  This study included 20 men and 12 women median age 66.5 years (range 43-78). GIST was incidentally found intra-operatively in 12 of the cases. All patients underwent surgery. Detection of the GIST was synchronous in 19 cases, metachronous in 7 cases and preceded the GIST diagnosis in 6 cases. The median time before follow-up evaluation ranged from 4 to 80 months.
  
  
  CONCLUSIONS
  To our knowledge, no cases of GISTs co-existing with leiomyosarcoma of the spermatic cord and larynx tumors have been reported previously. The prevalence of malignancies in this subpopulation of GIST patients is significantly higher than the prevalence of malignancies in the healthy Turkish population. The high occurrence rate of additional primary malignancies in GIST patients has focused the attention of clinical oncologists on this problem, and may imply a common genetic mechanism for their etiology.
authors.affiliation: Department of Medical Oncology, Gaziantep University, Gaziantep Oncology Hospital, Gaziantep, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Sevinc
authors.forename: Mesut
authors.initials: M
authors.lastname: Seker
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bilici
authors.forename: Nuriye Yildirim
authors.initials: NY
authors.lastname: Ozdemir
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yildiz
authors.forename: Basak Oven
authors.initials: BO
authors.lastname: Ustaalioglu
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Kalender
authors.forename: Faysal
authors.initials: F
authors.lastname: Dane
authors.forename: Halit
authors.initials: H
authors.lastname: Karaca
authors.forename: Cengiz
authors.initials: C
authors.lastname: Gemici
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gumus
authors.forename: Suleyman
authors.initials: S
authors.lastname: Buyukberber
mesh_terms: D000368:Aged; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*