title: Balancing act during development: lessons from a SUMO-less SF-1.
abstract: When a transcription factor is modified by small ubiquitin-like modifier (SUMO), this usually represses its transcriptional activity. In this issue of Developmental Cell, Lee et al. (2011) use a knockin mouse model to show that SUMO-less SF-1 binds and activates inappropriate targets, causing changes in cell fates and endocrine abnormalities.
authors.affiliation: Texas Heart Institute/St. Luke's Episcopal Hospital, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Feng-Ming
authors.initials: FM
authors.lastname: Lin
authors.forename: Edward T H
authors.initials: ET
authors.lastname: Yeh