title: Relevance of both type-1 and type-2 corticotropin releasing factor receptors in stress-induced relapse to cocaine seeking behaviour.
abstract: The essential role of corticotropin releasing factor (CRF) and its type-1 receptor (CRF1) in stress-induced relapse to drug seeking has been demonstrated. The bed nucleus of the stria terminalis is the major anatomical substrate for this CRF/CRF1 receptor action. More recently, the role of type-2 CRF (CRF2) receptors in stress-induced relapse to cocaine seeking has also has been documented. The ventral tegmental area is the anatomical substrate for this CRF/CRF2 receptor action. The new information involving CRF2 receptors in stress-induced relapse to cocaine seeking has generated a need for a reappraisal of the existing anatomical and pharmacological evidence that have been used to support the critical role of CRF1 receptors. The role of CRF2 receptors in stress-induced relapse to drug seeking also opens the question of the putative role of the other peptides of the CRH family (urocotin-1, urocortin-2 and urocortin-3) that have high affinity for CRF2 receptors. In this commentary, the available evidence supporting the role of both CRF1 and CRF2 receptors in stress-induced relapse to drug seeking is reviewed.
authors.affiliation: Millennium Science Nucleus in Stress and Addiction and Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile. kgysling@bio.puc.cl
authors.forename: Katia
authors.initials: K
authors.lastname: Gysling
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000378:metabolism* / Q000523:psychology; D019970:Cocaine-Related Disorders / Q000378:metabolism* / Q000523:psychology; D006801:Humans; D018019:Receptors, Corticotropin-Releasing Hormone / Q000502:physiology*; D012008:Recurrence; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology; D000099052:CRF Receptor, Type 1
chemical_list: C101531:CRF receptor type 2; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1