title: Effect of general anesthesia on plasma cardiac troponin I concentrations in healthy horses.
abstract: OBJECTIVE
  To evaluate the effect of general anesthesia on plasma cTnI concentrations in horses.
  
  
  METHODS
  Thirty-two horses undergoing general anesthesia and either elective surgery or MRI without surgery were prospectively studied. Twenty-nine horses (22 surgical, 7 imaging) completed the study. Plasma cTnI concentrations were determined prior to anesthesia and at 6, 12 and 24 h following discontinuation of the inhalant anesthetic.
  
  
  RESULTS
  All horses had cTnI values within the reference range at all time points. Six horses (21%) developed detectable cTnI 6 or 12 h following anesthesia. Risk factors for detectable cTnI include increasing age and dorsal recumbency. Horses with detectable cTnI had significantly lower mean and diastolic arterial blood pressures than those without detectable cTnI.
  
  
  CONCLUSIONS
  Uncomplicated general anesthesia with or without surgery does not result in cardiac troponin I elevations above the reference range in the first 24 h postoperatively.
authors.affiliation: Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, USA. slackj@vet.upenn.edu
authors.forename: Joann
authors.initials: J
authors.lastname: Slack
authors.forename: Raymond
authors.initials: R
authors.lastname: Boston
authors.forename: Bernd
authors.initials: B
authors.lastname: Driessen
authors.forename: Virginia
authors.initials: V
authors.lastname: Reef
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary*; D018681:Anesthetics, General / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006736:Horses / Q000097:blood*; D008297:Male; D012016:Reference Values; D019210:Troponin I / Q000097:blood*
chemical_list: D018681:Anesthetics, General; D019210:Troponin I