title: [The fundamental mechanisms of metastatic spread and chemotherapy resistance in lung cancer].
abstract: Lung cancer is the leading cause of cancer-related death in the European Union and the United States, accounting for about one third of all cancer deaths. Primary lung cancer may arise from the central (bronchial) or peripheral (bronchiolo-alveolar) compartment of the lung, but the origins of the different histological types of primary lung tumours are not well understood and described in medical literature. Current investigation in the field of cancer research have focused on the "cancer stem cell" hypothesis as stem cells are belived to be crucial players in the homeostasis of all adult tissues. Even if the role of stem cells in lung carcinogenesis is not clear yet, numerous studies indicate that lung cancer is not the result of a sudden transforming event, but of a multistep process of molecular changes of the primordial stem cell niche, leading to the development of noeplasia. In the current review, we present state-of-the-art research in the field of lung stem cell biology, with a special emphasis on lung cancer emergence, development, metastasis and multidrug resistance.
authors.affiliation: Departamentul de Imunologie Tumorală, Institutul Oncologic "Prof Dr. Ion Chiricuţă" Cluj-Napoca. ciprian.tomuleasa@gmail.com
authors.forename: Ciprian
authors.initials: C
authors.lastname: Tomuleasa
authors.forename: Gabriel
authors.initials: G
authors.lastname: Kacso
authors.forename: Olga
authors.initials: O
authors.lastname: Soritau
authors.forename: Sergiu
authors.initials: S
authors.lastname: Susman
authors.forename: Bobe
authors.initials: B
authors.lastname: Petrushev
authors.forename: Mihaela
authors.initials: M
authors.lastname: Aldea
authors.forename: Rareş
authors.initials: R
authors.lastname: Buiga
authors.forename: Alexandru
authors.initials: A
authors.lastname: Irimie
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D019008:Drug Resistance, Neoplasm; D005062:European Union / Q000706:statistics & numerical data; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D014411:Neoplastic Stem Cells / Q000473:pathology; D011013:Pneumonectomy; D011379:Prognosis; D012307:Risk Factors; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D012907:Smoking / Q000009:adverse effects; D014481:United States / Q000453:epidemiology