title: Intake of probiotic food and risk of preeclampsia in primiparous women: the Norwegian Mother and Child Cohort Study.
abstract: Probiotics have been suggested to modify placental trophoblast inflammation, systemic inflammation, and blood pressure, all potentially interesting aspects of preeclampsia. The authors examined the association between consumption of milk-based probiotic products in pregnancy and development of preeclampsia and its subtypes. The study was performed in the Norwegian Mother and Child Cohort Study by using a prospective design in 33,399 primiparous women in the years 2002-2008. The intake of milk-based products containing probiotic lactobacilli was estimated from a self-reported food frequency questionnaire. Preeclampsia diagnoses were obtained from the Norwegian Medical Birth Registry. Intake of probiotic milk products was associated with reduced risk of preeclampsia. The association was most prominent in severe preeclampsia (adjusted odds ratio (OR) = 0.79, 95% confidence interval (CI): 0.66, 0.96). With probiotic intakes divided into categories representing no, monthly, weekly, or daily intake, a lower risk for preeclampsia (all subtypes) was observed for daily probiotic intake (OR = 0.80, 95% CI: 0.66, 0.96). Lower risks for severe preeclampsia were observed for weekly (OR = 0.75, 95% CI: 0.57, 0.98) and daily (OR = 0.61, 95% CI: 0.43, 0.89) intakes. These results suggest that regular consumption of milk-based probiotics could be associated with lower risk of preeclampsia in primiparous women.
authors.affiliation: Department of Food Safety and Nutrition, Norwegian Institute of Public Health, Oslo, Norway. Anne.Lise.Brantsaeter@fhi.no
authors.forename: Anne Lise
authors.initials: AL
authors.lastname: Brantsaeter
authors.forename: Ronny
authors.initials: R
authors.lastname: Myhre
authors.forename: Margaretha
authors.initials: M
authors.lastname: Haugen
authors.forename: Solveig
authors.initials: S
authors.lastname: Myking
authors.forename: Verena
authors.initials: V
authors.lastname: Sengpiel
authors.forename: Per
authors.initials: P
authors.lastname: Magnus
authors.forename: Bo
authors.initials: B
authors.lastname: Jacobsson
authors.forename: Helle Margrete
authors.initials: HM
authors.lastname: Meltzer
mesh_terms: D000328:Adult; D000818:Animals; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008892:Milk; D009664:Norway / Q000453:epidemiology; D009753:Nutritive Value; D010298:Parity; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D019936:Probiotics / Q000008:administration & dosage*; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D014807:Vitamin D