title: Plasma coenzyme Q10 is increased during gestational diabetes.
abstract: OBJECTIVE
  To determine plasma CoQ(10) concentration in the course of gestational diabetes mellitus.
  
  
  METHODS
  The assessment was provided longitudinally during the third trimester of pregnancy in 40 women with gestational diabetes mellitus (GDM) and 40 normal controls. CoQ(10) was measured with the HPLC method. CoQ(10) results were also normalized to plasma cholesterol concentration (nmoles/mmoles). Plasma samples were collected longitudinally throughout the third trimester.
  
  
  RESULTS
  No statistically significant difference of plasma CoQ(10)/cholesterol levels between GDM patients and controls at 28-32 and 32-36 weeks of gestation, this difference was significant in late pregnancy (36-40 weeks), similarly, in the same gestational period, there was an increased level of HOMA-IR as index of insulin resistance ORAC as index of oxidative stress.
  
  
  CONCLUSIONS
  Since coenzyme Q(10) is believed to be an important cellular antioxidant defence, higher levels of CoQ(10) in GDM patients may be a compensatory mechanism, in response to an activated oxidative stress, probably associated to hyperglycaemia and insulin resistance.
authors.affiliation: Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy. s.giannubilo@univpm.it
authors.forename: Stefano Raffaele
authors.initials: SR
authors.lastname: Giannubilo
authors.forename: Luca
authors.initials: L
authors.lastname: Tiano
authors.forename: Stefano
authors.initials: S
authors.lastname: Cecchi
authors.forename: Federica
authors.initials: F
authors.lastname: Principi
authors.forename: Andrea Luigi
authors.initials: AL
authors.lastname: Tranquilli
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Littarru
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D016640:Diabetes, Gestational / Q000097:blood / Q000201:enzymology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007558:Italy; D008137:Longitudinal Studies; D018384:Oxidative Stress; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D014451:Ubiquinone; D002784:Cholesterol; C024989:coenzyme Q10