title: Genetic variation of myeloperoxidase gene contributes to preeclampsia: a preliminary association study in Turkish population.
abstract: OBJECTIVE
  To examine MPO gene polymorphisms of women with preeclampsia in Turkish population.
  
  
  METHODS
  Sixty-one preeclamptic and 61 normotensive women without history of preeclampsia in earlier pregnancies were enrolled in this prospective controlled study. MPO mutations were characterized by PCR-RFLP method.
  
  
  RESULTS
  We demonstrated a significant difference in patients with preeclampsia in terms of genotype frequency. Heterozygous carriers of -463A among preeclamptic pregnancies were significantly frequent, whereas rare A/A homozygotes failed to differ from controls.
  
  
  CONCLUSIONS
  The -463G/A polymorphism of leukocyte MPO could be an intriguing susceptibility factor that modulates an individual's risk of preeclampsia in Turkish population.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. ebruozturkarslan@yahoo.com
authors.forename: Ebru
authors.initials: E
authors.lastname: Ozturk
authors.forename: Ozcan
authors.initials: O
authors.lastname: Balat
authors.forename: Sacide
authors.initials: S
authors.lastname: Pehlivan
authors.forename: Mete Gurol
authors.initials: MG
authors.lastname: Ugur
authors.forename: Tugce
authors.initials: T
authors.lastname: Sever
mesh_terms: D000328:Adult; D017931:DNA Primers; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007962:Leukocytes; D009195:Peroxidase / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011225:Pre-Eclampsia / Q000201:enzymology / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D014421:Turkey; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: D017931:DNA Primers; D009195:Peroxidase