title: Deciphering the regulatory codes in bacterial genomes.
abstract: Interactions between cis-regulatory elements and trans-acting factors are fundamental for cellular functions such as transcription. With the revolution in microarrays and sequencing technologies, genome-wide binding locations of trans-acting factors are being determined in large numbers. The richness of the genome-scale information has revealed that the nature of the bacterial transcriptome and regulome are considerably more complex than previously expected. In addition, the emerging view of the bacterial transcriptome is revising the concept of the operon organization of the genome. This review describes current advances in the genome-scale analysis of the interaction between cis-regulatory elements and trans-acting factors in microorganisms.
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea. bcho@kaist.ac.kr
authors.forename: Byung-Kwan
authors.initials: BK
authors.lastname: Cho
authors.forename: Bernhard
authors.initials: B
authors.lastname: Palsson
authors.forename: Karsten
authors.initials: K
authors.lastname: Zengler
mesh_terms: D016680:Genome, Bacterial / Q000235:genetics*; D059014:High-Throughput Nucleotide Sequencing; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D049490:Systems Biology; D059467:Transcriptome