title: Lipid nanoparticles for brain targeting I. Formulation optimization.
abstract: The aim of this study was to optimize the formulation of lipid nanoparticles (NPs), intended for brain targeting, with the aid of a computer generated experimental design. The high pressure homogenization technique, selected for this purpose, was suitable to formulate the 3 investigated lipids (i.e., Softisan(®) 142, SOFT; Compritol(®) 888 ATO, COMP; cetyl palmitate, CP) into nanometre-length particles, while the computer generated experimental design helped to individuate the best preparation conditions with a small number of experimental assay. Even though all the 3 optimized formulations were suitable for intravenous infusion, CP NPs showed the smallest particle size and the appropriate thermal behaviour to be used as carriers in brain targeting applications.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, via del Liceo 1, 06123 Perugia, Italy. kaolino@unipg.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Blasi
authors.forename: Stefano
authors.initials: S
authors.lastname: Giovagnoli
authors.forename: Aurélie
authors.initials: A
authors.lastname: Schoubben
authors.forename: Carmelo
authors.initials: C
authors.lastname: Puglia
authors.forename: Francesco
authors.initials: F
authors.lastname: Bonina
authors.forename: Carlo
authors.initials: C
authors.lastname: Rossi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Ricci
mesh_terms: D001921:Brain / Q000378:metabolism*; D017076:Computer-Aided Design; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005227:Fatty Acids / Q000737:chemistry; D007262:Infusions, Intravenous; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles; D010168:Palmitates / Q000737:chemistry; D010316:Particle Size; D013696:Temperature; D014280:Triglycerides / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D005227:Fatty Acids; D008055:Lipids; D010168:Palmitates; D014280:Triglycerides; C086409:glyceryl behenate; C006957:cetyl palmitate