title: Measurement of NT-proBNP with LOCI technology in heart failure patients.
abstract: OBJECTIVE
  The aim of our study was to determine NT-proBNP concentrations in heart failure (HF) patients with a luminescent oxygen channeling immunoassay (LOCI).
  
  
  METHODS
  Seventy HF patients were enrolled. NT-proBNP levels were measured with LOCI method and compared to a reference NT-proBNP assay.
  
  
  RESULTS
  LOCI NT-proBNP levels were significantly correlated with the reference NT-proBNP assay and were related to HF severity.
  
  
  CONCLUSIONS
  LOCI assay demonstrates performances close to the comparative assay for NT-proBNP testing and allows a significant reduction of the time of analysis.
authors.affiliation: Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium. damien.gruson@uclouvain.be
authors.forename: D
authors.initials: D
authors.lastname: Gruson
authors.forename: Sylvie A
authors.initials: SA
authors.lastname: Ahn
authors.forename: Thibault
authors.initials: T
authors.lastname: Lepoutre
authors.forename: Michel F
authors.initials: MF
authors.lastname: Rousseau
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002309:Cardiology / Q000379:methods; D019411:Clinical Laboratory Techniques / Q000379:methods; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000032:analysis*; D010100:Oxygen / Q000737:chemistry; D010446:Peptide Fragments / Q000032:analysis*; D011863:Radioimmunoassay / Q000379:methods; D013997:Time Factors
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D010100:Oxygen