title: Prevalence, characteristics, and risk factors of elevated triglyceride levels in US children.
abstract: Limited information is available on the epidemiology of hypertriglyceridemia (HTG; 150-499 mg/dL) and severe HTG (SHTG; >500 mg/dL) in children. This study estimates the prevalence of HTG and SHTG, evaluates factors that may be associated with these conditions, and describes the use of dyslipidemic agents in children. The sample included children 12 to 19 years old who participated in National Health and Nutrition Examination Survey (NHANES) 2001-2008 (n = 3248) and children 5 to 19 years of age who were part of a large managed-care claims database in the United States (n = 65 258). Results from NHANES confirm the rarity of SHTG in the US pediatric population (ie, 0.2%). Factors statistically significantly associated with having HTG or SHTG in the claims database were being male, 12 to 19 years old, having high low-density lipoprotein (LDL), having low high-density lipoprotein (HDL), diabetes, and psychological disorders. Fibrates were the most commonly prescribed triglyceride-lowering agent among children with SHTG, followed by statins and Lovaza.
authors.affiliation: GlaxoSmithKline, Durham, NC, USA. Jennifer.B.Christian@gsk.com
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: Christian
authors.forename: Maneesh X
authors.initials: MX
authors.lastname: Juneja
authors.forename: Amy M
authors.initials: AM
authors.lastname: Meadowcroft
authors.forename: Spencer
authors.initials: S
authors.lastname: Borden
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Lowe
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D016015:Logistic Models; D008297:Male; D001523:Mental Disorders / Q000150:complications; D009749:Nutrition Surveys; D010865:Pilot Projects; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides