title: Apolipoprotein E is associated with blood lipids and inflammation in Taiwanese older adults.
abstract: Polymorphisms of the apolipoprotein E gene (ApoE) have been associated with health and longevity. Numerous studies have linked ApoE to health outcomes including cardiovascular disease and mortality, but far fewer studies have examined the relationship of ApoE to other biological markers of health. This study investigates the relationship between ApoE and mortality, as well as ApoE and a set of biomarkers related to cardiovascular and immune function, in a population-based sample of Taiwanese adults ages 54+. ApoE £2 carriers were less likely to have at-risk levels of high-density lipoprotein (HDL-C) and total cholesterol (total-C) than non-carriers (odds ratio [OR] 0.45, 95% confidence interval [CI] 0.25-0.83 and OR 0.45, 95% CI 0.29-0.71, respectively). ApoE £4 carriers were less likely to have elevated levels of C-reactive protein (CRP) than non-carriers (OR 0.62, 95% CI 0.39-0.96). ApoE genotype was not, however, associated with mortality after 8 years of follow-up. Our findings confirm the association between ApoE £2and cholesterol levels, suggesting a potential protective effect of ApoE £2 on blood lipids. They also contribute to reports on the relationship between ApoE £4 carrier status and lower CRP levels.
authors.affiliation: Office of Population Research, Princeton University, Princeton, NJ 08544, USA. svasunil@princeton.edu
authors.forename: Sarinnapha
authors.initials: S
authors.lastname: Vasunilashorn
authors.forename: Dana A
authors.initials: DA
authors.lastname: Glei
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Lan
authors.forename: Ron
authors.initials: R
authors.lastname: Brookmeyer
authors.forename: Maxine
authors.initials: M
authors.lastname: Weinstein
authors.forename: Noreen
authors.initials: N
authors.lastname: Goldman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology
chemical_list: D001057:Apolipoproteins E; D015415:Biomarkers; D008055:Lipids; D002097:C-Reactive Protein; D002784:Cholesterol