title: Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in mice.
abstract: Many people begin to experiment with alcohol during adolescence, an important developmental period during which sex differences in the effects of ethanol appear. In the present study we evaluated the effect of ethanol (0, 0.625, 1.25 or 2.5 g/kg) on the acquisition of a conditioned place preference (CPP) in early and late adolescent male and female mice. In addition, we assessed the capacity of ethanol to induce reinstatement of the CPP after its extinction. CPP was induced in early and late adolescent females with 2.5 g/kg, and in early adolescent males with 1.25 or 2.5 g/kg of ethanol. No CPP was observed in late adolescent males. Priming with ethanol reinstated the CPP induced by the highest dose in early adolescent male and early and late adolescent female mice. Our data suggest that early adolescents of both sex and late adolescent females are particularly vulnerable to the effects of ethanol.
authors.affiliation: Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de Valencia, Avda. Blasco Ibáñez, 21, 46010 Valencia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Roger-Sánchez
authors.forename: M A
authors.initials: MA
authors.lastname: Aguilar
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez-Arias
authors.forename: C M
authors.initials: CM
authors.lastname: Aragon
authors.forename: J
authors.initials: J
authors.lastname: Miñarro
mesh_terms: D000367:Age Factors; D020268:Alcohol-Induced Disorders, Nervous System / Q000209:etiology*; D000437:Alcoholism / Q000209:etiology*; D000818:Animals; D021461:Animals, Outbred Strains; D015984:Causality; D002492:Central Nervous System Depressants / Q000097:blood / Q000633:toxicity; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D000431:Ethanol / Q000097:blood / Q000633:toxicity*; D005260:Female; D007859:Learning Disabilities / Q000209:etiology*; D008297:Male; D051379:Mice; D060865:Repetition Priming / Q000187:drug effects* / Q000502:physiology; D012727:Sex Characteristics
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol