title: Solubilisation of griseofulvin and rutin in aqueous micellar solutions of gemini and heterogemini surfactants and their mixtures.
abstract: The solubilisation of two natural compounds, griseofulvin and rutin, in micellar solutions of mixtures of gemini (N,N'-didecyl-N,N,N',N'-tetramethylethane-1,2-diyldiammonium dibromide) and heterogemini (decyl 2-[decyl(dimethyl)ammonio]ethylphosphate) surfactants has been studied. The highest solubilisation capacities were found for mixtures with a molar fraction of heterogemini surfactant equal or greater than the molar fraction of gemini surfactant. The relationship between synergism in surface properties of mixtures of surfactants and their solubilisation properties was also investigated.
authors.affiliation: Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, 832 32 Bratislava, Slovakia. lukac@fpharm.uniba.sk
authors.forename: Miloš
authors.initials: M
authors.lastname: Lukáč
authors.forename: Ivan
authors.initials: I
authors.lastname: Prokipčák
authors.forename: Ivan
authors.initials: I
authors.lastname: Lacko
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Devínsky
mesh_terms: D006118:Griseofulvin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012431:Rutin / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D008823:Micelles; C570123:N,N'-didecyl-N,N,N',N'-tetramethylethane-1,2-diyldiammonium dibromide; D000644:Quaternary Ammonium Compounds; D012996:Solutions; D013501:Surface-Active Agents; C570124:decyl(2-decyl(dimethyl)ammonio)ethylphosphate; D006118:Griseofulvin; D012431:Rutin