title: Association between gene polymorphism of CD14-159 (C/T) and allergic asthma.
abstract: The objective of this study was to evaluate the possible association between the CD14-159 polymorphism and adult asthma in the Chinese population. A total of 188 asthmatic patients and 60 healthy adults were enrolled in the present study, and the CD14-159 polymorphism was genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR‑RFLP) analysis. The results showed that the frequencies of CC, CT and TT genotypes were 12.2, 47.9, and 39.9%, respectively, in the asthma group, and 8.3, 50.0, and 41.7%, respectively, in healthy adults, with no statistical difference between the two groups (P>0.05). The frequencies of C and T allele were 36.2 and 63.8%, respectively, in the asthma group, 33.3 and 66.7%, respectively, in the healthy group, and no statistical difference was observed in the allele frequencies between the two groups (P>0.05). Our data suggest that the CD14-159 polymorphism is not associated with adult asthma in Chinese population.
authors.affiliation: Medical Department of Lishui University, Lishui, Zhejiang 323000, PR China. wusq20100429@126.com
authors.forename: Song-Quan
authors.initials: SQ
authors.lastname: Wu
authors.forename: Kai-Bo
authors.initials: KB
authors.lastname: Zhang
authors.forename: Hai-Quan
authors.initials: HQ
authors.lastname: Chen
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Zhao
authors.forename: Guang-Li
authors.initials: GL
authors.lastname: Wang
authors.forename: Cong
authors.initials: C
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000235:genetics*; D001483:Base Sequence; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D018950:Lipopolysaccharide Receptors