title: [A case of clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with anti-glutamate receptor antibody].
abstract: We report the case of an 18-year-old boy who presented with disturbance of consciousness and generalized seizures following flu-like symptoms such as high fever and arthralgia. T2 and diffusion weighted brain magnetic resonance images showed a hyperintense ovoid lesion in the splenium of the corpus callosum and T, weighted images showed a hypointense lesion; the lesion completely disappeared on repeat imaging after 3 days. Antiglutamate epsilon2 receptor antibodies were detected in his cerebrospinal fluid. Although the patient had several episodes of generalized seizures, he completely recovered within 3 months. Our patient had a clinically mild encephalitis/encephalopathy with a reversible splenial lesion following flu-like symptoms, which indicated viral infection. As compared to previously reported cases, our case was characteristic because of the protracted recovery shown by the patient. Anti-glutamate epsilon2 receptor antibodies may be associated with prolonged generalized seizures in the case of our patient. Our results also suggest that anti-glutamate epsilon2 receptor antibodies may play a role in the pathogenesis of this condition.
authors.affiliation: Department of Internal Medicine, Seikeikai Hospital.
authors.forename: Youhei
authors.initials: Y
authors.lastname: Fujiki
authors.forename: Hideto
authors.initials: H
authors.lastname: Nakajima
authors.forename: Takumi
authors.initials: T
authors.lastname: Ito
authors.forename: Haruko
authors.initials: H
authors.lastname: Kitaoka
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Takahashi
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D003337:Corpus Callosum / Q000473:pathology*; D004660:Encephalitis / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008297:Male; D017470:Receptors, Glutamate / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D017470:Receptors, Glutamate