title: Prognostic factors influencing progression-free survival determined from a series of sporadic desmoid tumors: a wait-and-see policy according to tumor presentation.
abstract: OBJECTIVE
  Desmoid tumors are mesenchymal fibroblastic/myofibroblastic proliferations with locoregional aggressiveness and high ability to recur after initial treatment. We present the results of the largest series of sporadic desmoid tumors ever published to determine the prognostic factors of these rare tumors.
  
  
  METHODS
  Four hundred twenty-six patients with a desmoid tumor at diagnosis were included, and the following parameters were studied: age, sex, delay between first symptoms and diagnosis, tumor size, tumor site, previous history of surgery or trauma in the area of the primary tumor, surgical margins, and context of abdominal wall desmoids in women of child-bearing age during or shortly after pregnancy. We performed univariate and multivariate analysis for progression-free survival (PFS).
  
  
  RESULTS
  In univariate analysis, age, tumor size, tumor site, and surgical margins (R2 v R0/R1) had a significant impact on PFS. PFS curves were not significantly different for microscopic assessment of surgical resection quality (R0 v R1). In multivariate analysis, age, tumor size, and tumor site had independent values. Three prognostic groups for PFS were defined on the basis of the number of independent unfavorable prognostic factors (0 or 1, 2, and 3).
  
  
  CONCLUSIONS
  This study clearly demonstrates that there are different prognostic subgroups of desmoid tumors that could benefit from different therapeutic strategies, including a wait-and-see policy.
authors.affiliation: Département de Pathologie, Institut Bergonié. 229, cours de l'Argonne, Bordeaux, France CEDEX 33076. sebastien.salas@ap-hm.fr
authors.forename: Sébastien
authors.initials: S
authors.lastname: Salas
authors.forename: Armelle
authors.initials: A
authors.lastname: Dufresne
authors.forename: Binh
authors.initials: B
authors.lastname: Bui
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Blay
authors.forename: Philippe
authors.initials: P
authors.lastname: Terrier
authors.forename: Dominique
authors.initials: D
authors.lastname: Ranchere-Vince
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bonvalot
authors.forename: Eberhard
authors.initials: E
authors.lastname: Stoeckle
authors.forename: Louis
authors.initials: L
authors.lastname: Guillou
authors.forename: Axel
authors.initials: A
authors.lastname: Le Cesne
authors.forename: Odile
authors.initials: O
authors.lastname: Oberlin
authors.forename: Véronique
authors.initials: V
authors.lastname: Brouste
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Coindre
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005060:Europe; D005260:Female; D018222:Desmoid Tumors / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis