title: [The influence of suoquan capsule on the mRNA expression of CYP11B2 in deficiency of the kidney and diuresis rats].
abstract: OBJECTIVE
  To explore the mechanism of nourishing kidney and reducing urine effect of suoquan capsule by discussing the adjusting action on ALD synthase.
  
  
  METHODS
  Built the model of deficiency of the kidney and diuresis by adenine,inspectd the contents of Cort, ALD in blood and the mRNA expression of CYP11B2 with ELISA and RT-PCR technology of the mice.
  
  
  RESULTS
  Compared with model group, Suoquan capsule could remarkedly increase the contents of Cort, ALD in blood and the mRNA expression of CYP1 1 B2 of model rats.
  
  
  CONCLUSIONS
  Suoquan capsule can increase the contents of Cort, ALD in blood and the mRNA expression of CYP11B2 in deficiency of the kidney and diuresis rats. Promote the combining of ALD by adjusting the ALD synthase may be the mechanism of nourishing the kidney and reducing urine of Souquan capsule from ALD synthase approach.
authors.affiliation: Jiangxi College of Traditional Chinese Medicine, Fuzhou 344000, China. lswzyh@qq.com
authors.forename: Shu-wen
authors.initials: SW
authors.lastname: Li
authors.forename: Lv-jiang
authors.initials: LJ
authors.lastname: Hu
authors.forename: Qing-he
authors.initials: QH
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Cao
mesh_terms: D000225:Adenine / Q000009:adverse effects; D000450:Aldosterone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D004232:Diuretics; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D000450:Aldosterone; D019405:Cytochrome P-450 CYP11B2; D000225:Adenine; D003345:Corticosterone