title: Epitaxial growth of the zinc oxide nanorods, their characterization and in vitro biocompatibility studies.
abstract: Here, we have synthesized Zinc Oxide (ZnO) nanorods at room temperature using zinc acetate and hexamethylenetetramine as precursors followed by characterization using X-ray diffraction (XRD), fourier transform infra red spectroscopy, scanning electron microscopy (SEM) and transmission electron microscopy. The growth of the synthesized ZnO was found to be very close to its hexagonal nature, which is confirmed by XRD. The nanorods were grown perpendicular to the long-axis and grew along the [001] direction, which is the nature of ZnO growth. The morphology of the synthesized ZnO nanorods was also confirmed by SEM. The size of the nanorod was estimated to be around 20-25 nm in diameter and approximately 50-60 nm in length. Our biocompatibility studies using synthesized ZnO showed no significant dose- or time-dependent increase in the formation of free radicals, accumulation of peroxidative products, antioxidant depletion or loss of cell viability on lung epithelial cells.
authors.affiliation: Molecular Toxicology Laboratory, Center for Biotechnology and Biomedical Sciences, Department of Biology, Norfolk State University, Norfolk, VA 23504, USA.
authors.forename: Ramya
authors.initials: R
authors.lastname: Gopikrishnan
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.forename: Prabakaran
authors.initials: P
authors.lastname: Ravichandran
authors.forename: Santhoshkumar
authors.initials: S
authors.lastname: Biradar
authors.forename: Vani
authors.initials: V
authors.lastname: Ramesh
authors.forename: Virupaxi
authors.initials: V
authors.lastname: Goornavar
authors.forename: Robert B
authors.initials: RB
authors.lastname: Jeffers
authors.forename: Aswini
authors.initials: A
authors.lastname: Pradhan
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Hall
authors.forename: Sudhakar
authors.initials: S
authors.lastname: Baluchamy
authors.forename: Govindarajan T
authors.initials: GT
authors.lastname: Ramesh
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival; D004847:Epithelial Cells / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000009:adverse effects* / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D015034:Zinc Oxide / Q000009:adverse effects* / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001672:Biocompatible Materials; D005978:Glutathione; D015034:Zinc Oxide