title: Impact of IL2 and IL2RB genetic polymorphisms in kidney transplantation.
abstract: Patient genetic make-up may contribute to a higher risk for acute rejection episodes (AREs). Because interleukin-2 (IL2) and IL2 receptor β (IL2RB) play key roles in immune modulation, we investigated the effect of single-nucleotide polymorphisms (SNPs) in the IL2 gene (rs2069762; T>G, promoter; and rs2069763; G>T, exon 1, Leu38Leu) and IL2RB gene (rs228942: C>A, exon 1, Asp391Glu; and rs228953: C>T, exon 8, Gly250Gly) on renal ARE risk in 61 ARE patients and 276 control renal allograft recipients in Korea. The genotype frequencies of the IL2 and IL2RB SNPs showed Hardy-Weinberg equilibrium in both ARE and control groups. No significant difference in the genotype frequencies of the 2 IL2 SNPs was detected between non-ARE and ARE subjects (P > .05). The occurrence of AREs was significantly associated with genetic variants of the IL2RB gene (rs228942: odds ratio [OR] 2.11, 95% confidence interval [CI] 1.19-3.74; P = .0096, dominant model; rs228953: OR 1.58, 95% CI 1.04-2.38; P = .029, codominant model). In the haplotype-based analysis, the AC haplotype of IL2RB (χ(2) = 4.738; P = .0295) showed associations with ARE. Our results demonstrate that genetic variants of IL2RB may be associated with the development of AREs and may help predict ARE risk in kidney transplantation patients.
authors.affiliation: Organ Transplantation Center, College of Medicine, Inje University, Busan, South Korea.
authors.forename: S J
authors.initials: SJ
authors.lastname: Park
authors.forename: Y C
authors.initials: YC
authors.lastname: Yoon
authors.forename: S W
authors.initials: SW
authors.lastname: Kang
authors.forename: T H
authors.initials: TH
authors.lastname: Kim
authors.forename: Y W
authors.initials: YW
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Joo
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Jeong
authors.forename: D Y
authors.initials: DY
authors.lastname: Lee
authors.forename: S S
authors.initials: SS
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Chung
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D053646:Interleukin-2 Receptor beta Subunit / Q000235:genetics*; D016030:Kidney Transplantation / Q000276:immunology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D056910:Republic of Korea; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: C508594:IL2 protein, human; C508020:IL2RB protein, human; D007376:Interleukin-2; D053646:Interleukin-2 Receptor beta Subunit