title: Advances in tenascin-C biology.
abstract: Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.
authors.affiliation: Kennedy Institute of Rheumatology Division, Faculty of Medicine, NDORMS, Oxford University, 65 Aspenlea Road, Hammersmith, London W6 8LH, UK. kim.midwood@kennedy.ox.ac.uk
authors.forename: Kim S
authors.initials: KS
authors.lastname: Midwood
authors.forename: Thomas
authors.initials: T
authors.lastname: Hussenet
authors.forename: Benoit
authors.initials: B
authors.lastname: Langlois
authors.forename: Gertraud
authors.initials: G
authors.lastname: Orend
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D009203:Myocardial Infarction / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D032389:Myocytes, Smooth Muscle / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D051381:Rats; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology; D019063:Tenascin / Q000097:blood / Q000737:chemistry / Q000502:physiology*; D014652:Vascular Diseases / Q000378:metabolism / Q000473:pathology; D014945:Wound Healing / Q000502:physiology
chemical_list: D019063:Tenascin