title: Adenovirus-vectored drug-vaccine duo as a rapid-response tool for conferring seamless protection against influenza.
abstract: Few other diseases exert such a huge toll of suffering as influenza. We report here that intranasal (i.n.) administration of E1/E3-defective (ΔE1E3) adenovirus serotype 5 (Ad5) particles rapidly induced an anti-influenza state as a means of prophylactic therapy which persisted for several weeks in mice. By encoding an influenza virus (IFV) hemagglutinin (HA) HA1 domain, an Ad5-HA1 vector conferred rapid protection as a prophylactic drug followed by elicitation of sustained protective immunity as a vaccine for inducing seamless protection against influenza as a drug-vaccine duo (DVD) in a single package. Since Ad5 particles induce a complex web of host responses, which could arrest influenza by activating a specific arm of innate immunity to impede IFV growth in the airway, it is conceivable that this multi-pronged influenza DVD may escape the fate of drug resistance that impairs the current influenza drugs.
authors.affiliation: Vaxin, Inc., Birmingham, Alabama, United States of America.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhang
authors.forename: E Bart
authors.initials: EB
authors.lastname: Tarbet
authors.forename: Tsungwei
authors.initials: T
authors.lastname: Feng
authors.forename: Zhongkai
authors.initials: Z
authors.lastname: Shi
authors.forename: Kent R
authors.initials: KR
authors.lastname: Van Kampen
authors.forename: De-chu C
authors.initials: DC
authors.lastname: Tang
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use*; D005822:Genetic Vectors / Q000235:genetics*; D006304:Health Status; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000188:drug therapy / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D008168:Lung / Q000276:immunology / Q000473:pathology / Q000821:virology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D014611:Vaccination; D015431:Weight Loss
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D007252:Influenza Vaccines