title: Overview of peroxiredoxins in oxidant defense and redox regulation.
abstract: Peroxiredoxins are important hydroperoxide detoxification enzymes, yet have only come to the fore in recent years relative to the other major players in peroxide detoxification, heme-containing catalases and peroxidases and glutathione peroxidases. These cysteine-dependent peroxidases exhibit high reactivity with hydrogen peroxide, organic hydroperoxides, and peroxynitrite and play major roles not only in peroxide defense, but also in regulating peroxide-mediated cell signaling. This overview focuses on important peroxiredoxin features that have emerged over the past several decades with an emphasis on catalytic mechanism, regulation, and biological function.
authors.affiliation: Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Leslie B
authors.initials: LB
authors.lastname: Poole
authors.forename: Andrea
authors.initials: A
authors.lastname: Hall
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Nelson
mesh_terms: D000818:Animals; D002384:Catalysis; D006801:Humans; D008958:Models, Molecular; D010084:Oxidation-Reduction; D054464:Peroxiredoxins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
chemical_list: D054464:Peroxiredoxins