title: Sources of uncertainty about daughters' breast cancer risk that emerge during genetic counseling consultations.
abstract: Uncertainty is central to the experience of genetic decision making and counseling about cancer risk. Women seeking genetic counseling about their breast cancer risk may experience a great deal of uncertainty about issues related to their daughters. We used a theory of Communication and Uncertainty Management to guide analysis of sources of uncertainty about daughters that emerged during 16 video-recorded and transcribed conversations between mothers at risk for a BRCA 1/2 mutation and their genetic healthcare practitioners. An interpretive design and constant comparative method revealed three dominant patterns or themes representing sources of uncertainty mothers have relating to their daughters: disease risk, future cancer screening, and communication of related information to daughters. Both practitioners and mothers discussed these aspects of uncertainty. The findings identify the significant role uncertainty and familial concerns play in mothers' genetic testing decision making process. To assist genetic practitioners, we highlight daughter-related concerns that mothers are uncertain about and which are vital to their genetic counseling needs.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. bylundlc@mskcc.org
authors.forename: Carma L
authors.initials: CL
authors.lastname: Bylund
authors.forename: Carla L
authors.initials: CL
authors.lastname: Fisher
authors.forename: Dale
authors.initials: D
authors.lastname: Brashers
authors.forename: Shawna
authors.initials: S
authors.lastname: Edgerson
authors.forename: Emily A
authors.initials: EA
authors.lastname: Glogowski
authors.forename: Sherry R
authors.initials: SR
authors.lastname: Boyar
authors.forename: Yelena
authors.initials: Y
authors.lastname: Kemel
authors.forename: Sara
authors.initials: S
authors.lastname: Spencer
authors.forename: David
authors.initials: D
authors.lastname: Kissane
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D035501:Uncertainty