title: Glucocorticoid receptor and breast cancer.
abstract: Stress enhances glucocorticoid (GC) synthesis, which alters inflammation and immune responses, as well as cellular proliferation and apoptosis in a number of tissues. Increasingly, stress has been associated with cancer progression, and in particular in breast cancer. Consequently, an operational glucocorticoid receptor system in breast tissue influences breast cancer development. In this review, we summarize the data on the GC/GR system in normal and tumoral breast tissue. We also review the molecular mechanisms by which GCs control apoptosis and proliferation in breast cancer models and how GCs alter the chemotherapy of breast cancer treatment when used in combination. Finally, we discuss the participation of GR in breast tumorigenesis under hormone replacement therapy.
authors.affiliation: INSERM-UPMC, UMRS 938, Hôpital Saint-Antoine, 184 rue du Faubourg Saint Antoine, 75012, Paris, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Vilasco
authors.forename: Laudine
authors.initials: L
authors.lastname: Communal
authors.forename: Najat
authors.initials: N
authors.lastname: Mourra
authors.forename: Aurélie
authors.initials: A
authors.lastname: Courtin
authors.forename: Patricia
authors.initials: P
authors.lastname: Forgez
authors.forename: Anne
authors.initials: A
authors.lastname: Gompel
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001940:Breast / Q000166:cytology / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D011372:Progestins / Q000378:metabolism; D020239:Receptor Cross-Talk; D011960:Receptors, Estrogen / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism; D012306:Risk
chemical_list: D018931:Antineoplastic Agents, Hormonal; D005938:Glucocorticoids; D011372:Progestins; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D011980:Receptors, Progesterone