title: Pleuroparenchymal fibroelastosis in patients with pulmonary disease secondary to bone marrow transplantation.
abstract: This study presents four patients who underwent bone marrow transplantation and subsequently developed pleuroparenchymal fibroelastosis, hitherto reported as an idiopathic condition. All presented clinically with pneumothorax and subpleural fibrosis on high-resolution computed tomography. In addition to the expected obliterative bronchiolitis, histopathology showed coexistent subpleural changes, and the relationship of pathology in multiple anatomic compartments in post bone marrow transplantation pulmonary disease is discussed.
authors.affiliation: Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK. j.vonderthuesen@rbht.nhs.uk
authors.forename: Jan H
authors.initials: JH
authors.lastname: von der Thüsen
authors.forename: David M
authors.initials: DM
authors.lastname: Hansell
authors.forename: Masaki
authors.initials: M
authors.lastname: Tominaga
authors.forename: Paul A
authors.initials: PA
authors.lastname: Veys
authors.forename: Michael T
authors.initials: MT
authors.lastname: Ashworth
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Owens
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Nicholson
mesh_terms: D000293:Adolescent; D000328:Adult; D001344:Autopsy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001989:Bronchiolitis Obliterans / Q000209:etiology; D004549:Elastin / Q000032:analysis*; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000737:chemistry* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010995:Pleural Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011013:Pneumonectomy; D011030:Pneumothorax / Q000209:etiology; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D012008:Recurrence; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D004549:Elastin