title: Primary cutaneous diffuse large B-cell lymphoma, leg type and secondary cutaneous involvement by testicular B-cell lymphoma share identical clinicopathological and immunophenotypical features.
abstract: BACKGROUND
  Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL), leg type can eventually disseminate to extracutaneous sites including testes. In addition, patients with testicular lymphoma can develop specific skin involvement.
  
  
  OBJECTIVE
  We sought to describe similarities between PCDLBCL, leg type and testicular B-cell lymphoma affecting the skin.
  
  
  METHODS
  We report two cases with typical clinicopathological and immunophenotypical features of leg type lymphoma occurring simultaneously with a testicular B-cell lymphoma. We also report an additional case of PCDLBCL, leg type with secondary testicular involvement.
  
  
  RESULTS
  All cases presented with typical red tumors exclusively located on the legs. Histologically, all cases showed a diffuse nonepidermotropic infiltrate composed of large blastic cells mainly centroblastic type. Phenotype showed strong positivity for Bcl-2, MUM-1, and FOXP1. Epstein-Barr virus stains and CD30 were negative in the 3 cases. In all cases the testicular infiltration showed the same pathological and phenotypical changes to those observed in the skin.
  
  
  CONCLUSIONS
  This was a retrospective case series study.
  
  
  CONCLUSIONS
  Skin involvement by testicular B-cell lymphomas and PCDLBCL, leg type are indistinguishable on the basis of pathologic and immunophenotypical features, therefore specific investigation and clinic correlation are needed.
authors.affiliation: Department of Dermatology, Hospital de Viladecans, Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Muniesa
authors.forename: Ramon M
authors.initials: RM
authors.lastname: Pujol
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Estrach
authors.forename: Fernando
authors.initials: F
authors.lastname: Gallardo
authors.forename: M Pilar
authors.initials: MP
authors.lastname: García-Muret
authors.forename: Josefina
authors.initials: J
authors.lastname: Climent
authors.forename: Antonio
authors.initials: A
authors.lastname: Salar
authors.forename: Octavio
authors.initials: O
authors.lastname: Servitje
mesh_terms: D000368:Aged; D006801:Humans; D016130:Immunophenotyping; D007866:Leg; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D013736:Testicular Neoplasms / Q000556:secondary*