title: The influence of probiotic Enterococcus faecium strain L5 on the microbiota and cytokines expression in rats with dysbiosis induced by antibiotics.
abstract: The animal model of intestinal dysbiosis induced by antibiotics was created. Dysbiotic condition was confirmed by the changes in titre of the indigenous microbiota (excessive growth of opportunistic microorganisms and reduced number of lactobacilli, bifidobacteria and enterococci) and the appearance of dyspeptic symptoms. Consumption of the fermented milk product with probiotic strain Enterococcus faecium L5 led to the rapid disappearance of dysbiosis symptoms, normalisation of the microbiota, increase in expression of IL-10 and decrease in IL-8 expression.
authors.affiliation: Institute of Experimental Medicine, St. Petersburg, Russia.
authors.forename: E
authors.initials: E
authors.lastname: Tarasova
authors.forename: E
authors.initials: E
authors.lastname: Yermolenko
authors.forename: V
authors.initials: V
authors.lastname: Donets
authors.forename: Z
authors.initials: Z
authors.lastname: Sundukova
authors.forename: A
authors.initials: A
authors.lastname: Bochkareva
authors.forename: I
authors.initials: I
authors.lastname: Borshev
authors.forename: M
authors.initials: M
authors.lastname: Suvorova
authors.forename: I
authors.initials: I
authors.lastname: Ilyasov
authors.forename: V
authors.initials: V
authors.lastname: Simanenkov
authors.forename: A N
authors.initials: AN
authors.lastname: Suvorov
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004195:Disease Models, Animal; D016984:Enterococcus faecium / Q000254:growth & development* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000276:immunology; D016209:Interleukin-8 / Q000235:genetics* / Q000276:immunology; D007410:Intestinal Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D007422:Intestines / Q000276:immunology / Q000382:microbiology*; D008297:Male; D054892:Metagenome; D019936:Probiotics / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000900:Anti-Bacterial Agents; D016209:Interleukin-8; D016753:Interleukin-10