title: Co-processed MCC-Eudragit® E excipients for extrusion-spheronization.
abstract: This study investigates the extrusion-spheronization performance of some mixtures of co-processed microcrystalline cellulose and Eudragit® E (as excipients) and sorbitol (as soluble filler-disintegrant). Attention is focused on the dissolution rate of low water solubility drugs (hydrochlorothiazide is used as a model drug) from pellets prepared with these mixtures. All pellet formulations studied presented adequate morphological, flow and mechanical properties. The pellets prepared with co-processed MCC-Eudragit® E and sorbitol show a drug dissolution rate dependent on the content of Eudragit® E in the co-processed excipient and on the proportion of sorbitol incorporated. Furthermore, the pellets made with co-processed MCC-Eudragit® E incorporating the higher proportion of sorbitol (50%) show a very high dissolution rate of hydrochlorothiazide (HCT) and undergo rapid disintegration in the dissolution medium.
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Goyanes
authors.forename: Consuelo
authors.initials: C
authors.lastname: Souto
authors.forename: Ramón
authors.initials: R
authors.lastname: Martínez-Pacheco
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D019245:Compressive Strength; D004339:Drug Compounding / Q000379:methods*; D005079:Excipients / Q000737:chemistry*; D006852:Hydrochlorothiazide / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D008768:Methylmethacrylates; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D033362:Powder Diffraction; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D005079:Excipients; D008689:Methacrylates; D008768:Methylmethacrylates; D006852:Hydrochlorothiazide; C102808:Eudragit-E; D002482:Cellulose; C109691:microcrystalline cellulose