title: Role of interleukin-8 in differentiation of uncomplicated from complicated parapneumonic effusion.
abstract: The aim of this study was to investigate the value and significance of interleukin-8 in differentiation of uncomplicated parapneumonic effusion (UCPPE) from complicated parapneumonic effusion (CPPE). Using an IMMULITE 1000 Analyzer, with chemiluminescent immunometric assay, levels of interleukin-8 (IL-8) were measured in the pleural fluid of patients with UCPPE (n=30), and CPPE (n=30), and three classical parameters (pH, glucose, and LDH) in these two groups. Receiver-operating curves were to assess the sensitivity and specifity of interleukin-8 for differentiating between the two patient groups. IL-8 levels were statistically higher in the CPPE group. A positive significant correlation, was found between levels of IL-8 and and lactate dehydrogenase (LDH) (r=0.68, p<0.05). There was also a positive significant correlation between IL-8 and protein level in pleural effusion (r=0.306, r<0.01). There was a significant negative correlation between levels of IL-8 and pH (r=-0.83, p<0.05), and of IL-8 and glucose in pleural fluid (r=-0.61, p<0.05). A cut-off value of 1805.81 pg/ml, differentiated CPPE from UPPE with a sensitivity of 100% and a specifity of 98%. IL-8 may be used as an alternative marker for the complication of parapneumonic effusion.
authors.affiliation: Infectious Diseases Clinic, Clinical Centre, Medical Faculty, Skopje, R. Macedonia.
authors.forename: S
authors.initials: S
authors.lastname: Petrusevska Marinkovic
authors.forename: I
authors.initials: I
authors.lastname: Kondova Topuzovska
authors.forename: Z
authors.initials: Z
authors.lastname: Milenkovic
authors.forename: G
authors.initials: G
authors.lastname: Kondov
authors.forename: G
authors.initials: G
authors.lastname: Bosevska
authors.forename: A
authors.initials: A
authors.lastname: Anastasovska
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D005947:Glucose / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D016209:Interleukin-8 / Q000032:analysis / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D011014:Pneumonia / Q000150:complications*; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D016209:Interleukin-8; D007770:L-Lactate Dehydrogenase; D005947:Glucose