title: Renal hyperperfusion injury resulting in transient proteinuria post renal artery angioplasty for fibromuscular dysplasia.
abstract: Renovascular hypertension (RVH) can be treated utilizing medical, surgical or endovascular techniques. We present a case in which severe exacerbation of pre-existing proteinuria followed percutaneous transluminal angioplasty of a highly stenotic renal artery to relieve RVH caused by fibromuscular dysplasia. We propose that the worsening proteinuria post-angioplasty was caused by a transient renal hyperperfusion injury that overcame the glomerular autoregulatory mechanisms, thereby leading to raised intraglomerular pressures and loss of proteins through the glomerular filtration barrier until the vascular autoregulatory ability of the glomeruli was successfully re-established.
authors.affiliation: Department of Radiology, University of British Columbia, Vancouver, Canada. mheran@cw.bc.ca
authors.forename: Manraj K S
authors.initials: MK
authors.lastname: Heran
authors.forename: Bippan S
authors.initials: BS
authors.lastname: Sangha
authors.forename: Colin
authors.initials: C
authors.lastname: White
mesh_terms: D000293:Adolescent; D017130:Angioplasty / Q000009:adverse effects*; D005260:Female; D005352:Fibromuscular Dysplasia / Q000150:complications* / Q000601:surgery*; D006801:Humans; D006977:Hypertension, Renal / Q000175:diagnosis / Q000209:etiology*; D012077:Renal Artery / Q000601:surgery*; D012078:Renal Artery Obstruction / Q000209:etiology* / Q000601:surgery*