title: Three-component synthesis of polysubstituted pyrroles from α-diazoketones, nitroalkenes, and amines.
abstract: Polysubstituted pyrroles are regiospecifically synthesized via the copper-catalyzed three-component reaction of α-diazoketones, nitroalkenes, and amines under aerobic conditions. The cascade process involves an N-H insertion of carbene, a copper-catalyzed oxidative dehydrogenation of amine, and a [3 + 2] cycloaddition of azomethine ylide.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
authors.forename: Deng
authors.initials: D
authors.lastname: Hong
authors.forename: Yuanxun
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.forename: Xufeng
authors.initials: X
authors.lastname: Lin
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
authors.forename: Yanguang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000588:Amines; D007659:Ketones; D009574:Nitro Compounds; D011758:Pyrroles