title: Impact of smoking during pregnancy on functional coagulation testing.
abstract: Compounds that are systemically absorbed during the course of cigarette smoking, and their metabolites, affect the coagulation system and cause endothelial dysfunction, dyslipidemia, and platelet activation leading to a prothrombotic state. In addition, smoking increases the activity of fibrinogen, homocysteine, and C-reactive protein. We hypothesize that smoking may affect functional coagulation testing during pregnancy. A secondary analysis of 371 women pregnant with a singleton pregnancy and enrolled in a multicenter, prospective observational study of complications of factor V Leiden mutation subsequently underwent functional coagulation testing for antithrombin III, protein C antigen and activity, and protein S antigen and activity. Smoking was assessed by self-report at time of enrollment (<14 weeks). None of the functional coagulation testing results was altered by maternal smoking during pregnancy. Smoking does not affect the aforementioned functional coagulation testing results during pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, USA. donna.dizon-townson@imail.org
authors.forename: Donna
authors.initials: D
authors.lastname: Dizon-Townson
authors.forename: Connie
authors.initials: C
authors.lastname: Miller
authors.forename: Valerija
authors.initials: V
authors.lastname: Momirova
authors.forename: Baha
authors.initials: B
authors.lastname: Sibai
authors.forename: Catherine Y
authors.initials: CY
authors.lastname: Spong
authors.forename: George
authors.initials: G
authors.lastname: Wendel
authors.forename: Katharine
authors.initials: K
authors.lastname: Wenstrom
authors.forename: Philip
authors.initials: P
authors.lastname: Samuels
authors.forename: Steve
authors.initials: S
authors.lastname: Caritis
authors.forename: Yoram
authors.initials: Y
authors.lastname: Sorokin
authors.forename: Menachem
authors.initials: M
authors.lastname: Miodovnik
authors.forename: Mary J
authors.initials: MJ
authors.lastname: O'Sullivan
authors.forename: Deborah
authors.initials: D
authors.lastname: Conway
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Wapner
authors.forename: Steven G
authors.initials: SG
authors.lastname: Gabbe
mesh_terms: D000328:Adult; D000990:Antithrombin III / Q000032:analysis / Q000378:metabolism; D001777:Blood Coagulation / Q000502:physiology*; D001780:Blood Coagulation Tests / Q000706:statistics & numerical data; D001798:Blood Proteins / Q000032:analysis* / Q000378:metabolism*; D005165:Factor V / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000378:metabolism*; D011446:Prospective Studies; D011486:Protein C / Q000032:analysis / Q000378:metabolism; D017293:Protein S / Q000032:analysis / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects / Q000378:metabolism*
chemical_list: D001798:Blood Proteins; D011486:Protein C; D017293:Protein S; D000990:Antithrombin III; D005165:Factor V