title: B-Myb, cancer, senescence, and microRNAs.
abstract: The transcription factor B-Myb plays a critical role in regulating gene expression and is implicated in controlling carcinogenesis and cellular senescence. Transcription of the B-Myb gene is regulated by retinoblastoma proteins acting directly on the B-Myb promoter. Recently, we found that microRNAs also control the abundance of B-Myb mRNA during senescence, adding another level of complexity to B-Myb regulation. This review focuses on the importance of B-Myb in cancer and senescence, with an emphasis on the regulation of B-Myb expression and activity.
authors.affiliation: Department of Genetics and Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, Connecticut 06520-8005, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Martinez
authors.forename: Daniel
authors.initials: D
authors.lastname: Dimaio
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D049109:Cell Proliferation; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D011401:Promoter Regions, Genetic; D012323:RNA Processing, Post-Transcriptional; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; C064352:MYBL2 protein, human; D035683:MicroRNAs; D015534:Trans-Activators