title: Piperidine-mediated synthesis of thiazolyl chalcones and their derivatives as potent antimicrobial agents.
abstract: A series of new thiazolyl chalcones, 1-[2-amino-4-methyl-1,3-thiazol-5-yl]-3-aryl-prop-2-en-1-one were prepared by piperidine mediated Claisen-Schmidt condensation of thiazolyl ketone with aromatic aldehyde. These chalcones on cyclisation gave 2-amino-6-(2-amino-4-methyl-1,3-thiazol-5-yl)-4-aryl-4H-pyridine-3-carbonitrile and 2-amino-6-(2-amino-4-methyl-1,3-thiazol-5-yl)-4-aryl-4H-pyran-3-carbonitrile. The result showed that the compounds exhibited marked potency as antimicrobial agents.
authors.affiliation: Department of Chemistry, Mahendra Institute of Technology, Namakkal 637503, India. venkatesanps@yahoo.co.in
authors.forename: P
authors.initials: P
authors.lastname: Venkatesan
authors.forename: T
authors.initials: T
authors.lastname: Maruthavanan
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D047188:Chalcones / Q000096:biosynthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010880:Piperidines / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D047188:Chalcones; D010880:Piperidines