title: [Non-invasive assessment of renal oxygenation with BOLD MRI in patients with type 2 diabetes].
abstract: OBJECTIVE
  To evaluate renal oxygenation in patients with type 2 diabetes using blood oxygenation level-dependent magnetic resonance imaging (BOLD MRI).
  
  
  METHODS
  The R2* values of cortex and medulla as well as cortical thickness were measured in 25 patients with type 2 diabetes and 30 normal controls. The associations between R2* values and clinical parameters were analyzed.
  
  
  RESULTS
  The medulla R2* value of the patients with diabetes was significantly higher than that of the normal controls. No significant difference in cortical thickness was found between the patients with diabetes and the normal controls. The medulla R2* value increased with eGFR in the patients with diabetes.
  
  
  CONCLUSIONS
  BOLD MRI is a non-invasive and efficient method to assess the oxygenation in different regions of kidney. Abnormality of kidney in diabetic patients can be detected earlier by BOLD MRI than traditional imaging.
authors.affiliation: Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Yin
authors.forename: Meng-Shu
authors.initials: MS
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.forename: Rong-Bo
authors.initials: RB
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*
chemical_list: D010100:Oxygen