title: Insulin resistance index (HOMA-IR) levels in a general adult population: curves percentile by gender and age. The EPIRCE study.
abstract: OBJECTIVE
  To describe the distribution of HOMA-IR levels in a general nondiabetic population and its relationships with metabolic and lifestyles characteristics.
  
  
  METHODS
  Cross-sectional study. Data from 2246 nondiabetic adults in a random Spanish population sample, stratified by age and gender, were analyzed. Assessments included a structured interview, physical examination, and blood sampling. Generalized additive models (GAMs) were used to assess the effect of lifestyle habits and clinical and demographic measurements on HOMA-IR. Multivariate GAMs and quantile regression analyses of HOMA-IR were carried out separately in men and women.
  
  
  RESULTS
  This study shows refined estimations of HOMA-IR levels by age, body mass index, and waist circumference in men and women. HOMA-IR levels were higher in men (2.06) than women (1.95) (P=0.047). In women, but not men, HOMA-IR and age showed a significant nonlinear association (P=0.006), with increased levels above fifty years of age. We estimated HOMA-IR curves percentile in men and women.
  
  
  CONCLUSIONS
  Age- and gender-adjusted HOMA-IR levels are reported in a representative Spanish adult non-diabetic population. There are gender-specific differences, with increased levels in women over fifty years of age that may be related with changes in body fat distribution after menopause.
authors.affiliation: Clinical Epidemiology and Biostatistics Unit, Hospital Clínico Universitario de Santiago de Compostela, Spain. pilar.gayoso.diz@sergas.es
authors.forename: Pilar
authors.initials: P
authors.lastname: Gayoso-Diz
authors.forename: Alfonso
authors.initials: A
authors.lastname: Otero-Gonzalez
authors.forename: María Xosé
authors.initials: MX
authors.lastname: Rodriguez-Alvarez
authors.forename: Francisco
authors.initials: F
authors.lastname: Gude
authors.forename: Carmen
authors.initials: C
authors.lastname: Cadarso-Suarez
authors.forename: Fernando
authors.initials: F
authors.lastname: García
authors.forename: Angel
authors.initials: A
authors.lastname: De Francisco
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D055815:Young Adult