title: Liver transplantation in patients with cryptogenic cirrhosis: long-term follow-up.
abstract: OBJECTIVE
  The objective of this study was to evaluate long-term survival, histological diagnoses, and mobility of patients with cryptogenic cirrhosis (CC) treated with orthotopic liver transplantation (OLT).
  
  
  METHODS
  We performed a retrospective analysis of 35 patients who underwent transplantation with CC among 800 OLT patients. There were no differences in gender, mean age of 47 years, average MELD (Model for End-stage Liver Disease) of 16, and hepatocellular carcinoma incidence (8%).
  
  
  RESULTS
  In 28.6% of patients, the diagnosis of CC was wrong. There was no incidence of an acute rejection episode and a low incidence of complications, although the postoperative mortality rate was 20%, of chronic rejection was 25%, and recurrence of disease was 4%. Cumulative at 3-, 5-, and 10-year survivals were lower than the other OLT. Survival was lower in patients receiving suboptimal grafts.
  
  
  CONCLUSIONS
  One of 3 patients who underwent transplantation for CC had a specific etiologic diagnosis. The chronic rejection rate and postoperative mortality rate were higher than other etiologies, and survivals at 5, 10, and 15 years were lower than other OLT.
authors.affiliation: Liver Transplant Unit, Virgen del Rocío Hospital, Seville, Spain. jmalamom@hotmail.com
authors.forename: J M
authors.initials: JM
authors.lastname: Álamo
authors.forename: C
authors.initials: C
authors.lastname: Bernal
authors.forename: L
authors.initials: L
authors.lastname: Barrera
authors.forename: L M
authors.initials: LM
authors.lastname: Marín
authors.forename: G
authors.initials: G
authors.lastname: Suárez
authors.forename: J
authors.initials: J
authors.lastname: Serrano
authors.forename: M A
authors.initials: MA
authors.lastname: Gómez
authors.forename: F J
authors.initials: FJ
authors.lastname: Padillo
mesh_terms: D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects / Q000276:immunology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013030:Spain; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome