title: Prognostic significance of CD44s expression in resected non-small cell lung cancer.
abstract: BACKGROUND
  CD44s is a cell adhesion molecule known to mediate cellular adhesion to the extracellular matrix, a prerequisite for tumor cell migration. CD44s plays an important role in invasion and metastasis of various cancers. In the present study, we sought to determine whether CD44s is involved in clinical outcomes of patients with resected non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Using immunohistochemical staining, we investigated CD44s protein expression using tissue array specimens from 159 patients with resected NSCLC (adenocarcinoma (AC; n=82) and squamous cell carcinoma (SCC; n=77). Additionally, the immunoreactivity of cyclooxygenase (COX)-2 was also studied. The clinicopathological implications of these molecules were analyzed statistically.
  
  
  RESULTS
  High CD44s expression was detected more frequently in NSCLC patients with SCC (66/72; 91.7%) than in those with AC histology (P<0.001). Additionally, high CD44s expression was significant correlated with more advanced regional lymph node metastasis (P=0.021). In multivariate analysis of survival in NSCLC patients with AC histology, significant predictors were lymph node metastasis status (P<0.001), high-grade tumor differentiation (P=0.046), and high CD44s expression (P=0.014). For NSCLC patients with SCC histology, the significant predictor was a more advanced tumor stage (P=0.015). No significant association was found between CD44s and clinical outcome (P=0.311).
  
  
  CONCLUSIONS
  High CD44s expression was a negative prognostic marker with significance in patients with resected NSCLC, particularly those with AC histology, and was independent of tumor stage.
authors.affiliation: Division of Oncology, Department of Internal Medicine, Seoul St, Mary's Hospital, Catholic University, Seoul, South Korea.
authors.forename: Yoon Ho
authors.initials: YH
authors.lastname: Ko
authors.forename: Hye Sung
authors.initials: HS
authors.lastname: Won
authors.forename: Eun Kyoung
authors.initials: EK
authors.lastname: Jeon
authors.forename: Sook Hee
authors.initials: SH
authors.lastname: Hong
authors.forename: Sang Young
authors.initials: SY
authors.lastname: Roh
authors.forename: Young Seon
authors.initials: YS
authors.lastname: Hong
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Byun
authors.forename: Chan-Kwon
authors.initials: CK
authors.lastname: Jung
authors.forename: Jin Hyoung
authors.initials: JH
authors.lastname: Kang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: C473647:CD44S antigen; D018960:Hyaluronan Receptors