title: Combined experimental and computational strategies define an expansive regulon for GcvB small RNA.
abstract: The bacterial small RNA GcvB has been known as a translational repressor of mRNAs encoding amino acid transporters and has been postulated to limit uptake of unnecessary amino acids under nutrient-rich conditions. In this issue of Molecular Microbiology, Sharma et al. (2011) provide evidence for a much broader role for GcvB as a global regulator of amino acid metabolism. Using a unique combination of experimental and biocomputational approaches, the authors triple the size of the GcvB regulon, making it the largest sRNA regulon defined to date.
authors.affiliation: Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. cvanderp@life.illinois.edu
authors.forename: Carin K
authors.initials: CK
authors.lastname: Vanderpool
mesh_terms: D026905:Amino Acid Transport Systems / Q000235:genetics* / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001693:Biological Transport, Active / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D005998:Glycine; D014176:Protein Biosynthesis / Q000235:genetics; D012329:RNA, Bacterial / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D020733:RNA, Small Cytoplasmic / Q000378:metabolism*; D058727:RNA, Small Untranslated / Q000235:genetics* / Q000378:metabolism; D018085:Regulon / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D026905:Amino Acid Transport Systems; D000596:Amino Acids; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D012329:RNA, Bacterial; D012333:RNA, Messenger; D020733:RNA, Small Cytoplasmic; D058727:RNA, Small Untranslated; D014157:Transcription Factors; D005998:Glycine