title: [In vivo transmigration of active ingredients from Gastrodia elata in dachuanxiong fang].
abstract: OBJECTIVE
  To investigate the substance basis of Gastrodia elata in Dachuanxiong Fang (DF) by serum pharmacochemistry, so that the quality of DF as well as its preparations can be effectively and systemically controlled.
  
  
  METHODS
  The chromatographic peaks of blank plasma, blank cerebrospinal fluid, drug-contained plasma and cerebrospinal fluid were compared by HPLC fingerprints. The absorbed ingredients of the active parts extracted from G. elata were structurally identified by HPLC-DAD-MS".
  
  
  RESULTS
  Two components, which were definitely detectable in rat plasma following the oral administration of the active parts from G. elata, were identified as gastrodin and parishin. In rat cerebrospinal fluid, there are, however, no obvious peaks that belong to the ingredients from G. elata.
  
  
  CONCLUSIONS
  Research on in vivo transmigration of ingredients from G. elata is favorable to the clarification of its active substance basis.
authors.affiliation: Engineering Research Center of Modern Preparation Technology of Traditional Chinese medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.forename: Ying
authors.initials: Y
authors.lastname: Yuan
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Hong
authors.forename: Desheng
authors.initials: D
authors.lastname: Xu
authors.forename: Lan
authors.initials: L
authors.lastname: Shen
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D031668:Gastrodia / Q000737:chemistry*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal