title: [Inhibition effect and mechanism of artemisnin on surgically induced endometriosis].
abstract: OBJECTIVE
  To evaluate the inhibitory effect of artemisnin on surgically induced endometriosis in rat model and the possible mechanism related to cellular apoptosis and microvascular angiogenesis.
  
  
  METHODS
  Surgically induced endometriosis model was established with female rats, and then the rats were divided into four groups: high dose artemisinin [300 mg/(kg x d)), low dose artemisinin [150 mg/(kg x d)], danazol [160 mg/(kg x d)] and solvent control group After daily administration of the above agents for 4 weeks, the rats were sacrificed, then the implant size of ectopic endometrium was measured and appotosis index (AI), Bcl-2 and MVD in ectopic endometrium were evaluated with S-P immunohistochemistry.
  
  
  RESULTS
  Compared with solvent control, both artemisinin (high and low quality) and danazol decrease the size of implants significantly (P < 0.05), and there was no significant difference among the three treatment groups. AI of the three treatment groups increased significantly, while Bcl-2 and MVD decreased significantly (P < 0.05). AI of both artemisinin groups were significantly higher than that of danazol group, but Bcl-2 level was lower.
  
  
  CONCLUSIONS
  Artemisnin inhibits surgically induced endometriosis in rats, and the possible mechanism may be related to stimulatation of cellular apoptosis and inhibition of angiogenesis.
authors.affiliation: Department of Obestetricts and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Fang
authors.forename: Xiao-Qian
authors.initials: XQ
authors.lastname: Wang
authors.forename: Hong-Jing
authors.initials: HJ
authors.lastname: Wang
authors.forename: Xi-Biao
authors.initials: XB
authors.lastname: Jia
authors.forename: Lin-Yun
authors.initials: LY
authors.lastname: Yang
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D037621:Artemisinins / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D020533:Angiogenesis Inhibitors; D037621:Artemisinins