title: Reaction of β-lactam carbenes with 2-pyridyl isonitriles: a one-pot synthesis of 2-carbonyl-3-(pyridylamino)imidazo[1,2-a]pyridines useful as fluorescent probes for mercury ion.
abstract: The one-pot reaction of β-lactam carbenes with 2-pyridyl isonitriles followed by an acidic hydrolysis was reported, which produced 2-carbonyl-3-(pyridylamino)imidazo[1,2-a]pyridines in moderate to good yields. Among the resulting novel imidazo[1,2-a]pyridine derivatives, 1-(6-chloro-3-(5-chloropyridin-2-ylamino)imidazo[1,2-a]pyridin-2-yl)-2-ethylbutan-1-one was demonstrated to be an efficient fluorescent probe for mercury ion both in acetonitrile and in buffered aqueous solution.
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Na
authors.initials: N
authors.lastname: Shao
authors.forename: Guang-Xian
authors.initials: GX
authors.lastname: Pang
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: Yan
authors.forename: Gao-Feng
authors.initials: GF
authors.lastname: Shi
authors.forename: Ying
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D008628:Mercury / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D047090:beta-Lactams / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D009570:Nitriles; D011725:Pyridines; D047090:beta-Lactams; C030011:carbene; D008628:Mercury; D008697:Methane