title: Lack of association between eotaxin-1 gene polymorphisms and nasal polyposis.
abstract: OBJECTIVE
  To examine whether there is an association of eotaxin-1 gene polymorphisms with nasal polyposis (NP).
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  The study group included 85 patients with NP and 93 controls without sinonasal disease. Genotypes of eotaxin-1 (-384 A>G and +67 G>A) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.
  
  
  RESULTS
  The -384 A>G and +67 G>A single nucleotide polymorphisms were higher in patients with NP than in controls (P = .044 and P = .019, respectively). However, their relation was statistically poor (association coefficient = 0.18). Consistent with this result, comparisons of allele frequencies for both single nucleotide polymorphisms were not significantly different (-384 A>G, P = .164; +67 G>A, P = .144).
  
  
  CONCLUSIONS
  In this study, eotaxin-1 -384 A>G or 67 G>A genotypes were not associated with susceptibility to NP.
authors.affiliation: Department of Otolaryngology, Baskent University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Ekinci
authors.forename: Selim S
authors.initials: SS
authors.lastname: Erbek
authors.forename: Erkan
authors.initials: E
authors.lastname: Yurtcu
authors.forename: Feride I
authors.initials: FI
authors.lastname: Sahin
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D016022:Case-Control Studies; D054413:Chemokine CCL11 / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005786:Gene Expression Regulation; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D054413:Chemokine CCL11