title: [Opioid rotation: from theory to practice. Interdisciplinary recommendations from the Geneva University Hospitals pain network].
abstract: Opioids are widely used to treat moderate to severe pain of cancer or non cancer origin. Although opioids provide an adequate analgesia in many patients, their use can be limited by inefficacy and/or intolerable side effects. Opioid rotation is one of the strategies that have been proposed to overcome these therapeutic difficulties. This article revisits the concept of opioid rotation, from pharmacological rational to clinical application.
authors.affiliation: Service de Pharmacologie et Toxicologie Cliniques, HUG, Genève. lucien.roulet@hcuge.ch
authors.forename: L
authors.initials: L
authors.lastname: Roulet
authors.forename: C
authors.initials: C
authors.lastname: Luthy
authors.forename: N
authors.initials: N
authors.lastname: Garin
authors.forename: L
authors.initials: L
authors.lastname: Di Pollina de Gold
authors.forename: D
authors.initials: D
authors.lastname: Zoccatelli
authors.forename: M
authors.initials: M
authors.lastname: Escher Imhof
authors.forename: J
authors.initials: J
authors.lastname: Desmeules
authors.forename: V
authors.initials: V
authors.lastname: Piguet
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D006785:Hospitals, University; D006801:Humans; D033183:Interdisciplinary Communication; D009369:Neoplasms / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D011957:Receptors, Opioid / Q000187:drug effects*; D013557:Switzerland
chemical_list: D000701:Analgesics, Opioid; D011957:Receptors, Opioid