title: A case of McCune-Albright syndrome associated with pituitary GH adenoma: therapeutic process and autopsy.
abstract: BACKGROUND
  McCune-Albright syndrome (MAS) is a clinical syndrome with low incidence, and its concurrence with pituitary GH adenoma is rare. Little of the history, treatment and outcome has been studied.
  
  
  METHODS
  Follow-up of a 37-year-old male patient of MAS associated with pituitary GH adenoma was performed continuously recording the disease development and the treatment process until death, after which an autopsy was performed.
  
  
  RESULTS
  Radiation therapy (RT) efficaciously controlled GH hypersecretion, however, it may have been the cause of the malignant transformation of the dysplastic bone tissue, which eventually caused brain hernia and death; autopsy demonstrated that the cranium had significant thickening (as much as 10 cm), the pathological diagnosis was fibrous dysplasia of bone associated with chondrosarcoma; and undifferentiated chondrosarcoma with malignant fibrous histocytoma subtype in the sellar region; nodular goiter with the thyroid gland, one nodus was pathologically demonstrated as papillary carcinoma.
  
  
  CONCLUSIONS
  GH adenoma, present in a patient with MAS, might be cured by RT; but the risk of malignant transformation of the dysplastic bone tissue in the field of irradiation make it controversial. Lessons from the case reported here told us that we should take great caution when recommending RT for patients like this.
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hang Zhou 310009, China.
authors.forename: Fuyi
authors.initials: F
authors.lastname: Liu
authors.forename: Wenting
authors.initials: W
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Yao
authors.forename: Guilin
authors.initials: G
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Wanchen
authors.initials: W
authors.lastname: Dou
authors.forename: Dingrong
authors.initials: D
authors.lastname: Zhong
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Zhu
authors.forename: Hua
authors.initials: H
authors.lastname: Hu
authors.forename: Jianmin
authors.initials: J
authors.lastname: Zhang
authors.forename: Renzhi
authors.initials: R
authors.lastname: Wang
authors.forename: Gao
authors.initials: G
authors.lastname: Chen
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000473:pathology / Q000628:therapy; D000236:Adenoma / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D000328:Adult; D001344:Autopsy; D001859:Bone Neoplasms / Q000209:etiology / Q000473:pathology; D002813:Chondrosarcoma / Q000209:etiology / Q000473:pathology; D017809:Fatal Outcome; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D005877:Gigantism / Q000150:complications / Q000473:pathology / Q000628:therapy; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000473:pathology