title: Clarithromycin induced reversible sensorineural hearing loss.
abstract: OBJECTIVE
  We present a rare case of reversible sensorineural hearing loss caused by clarithromycin.
  
  
  METHODS
  We present a case report of hearing loss following clarithromycin administration; we also review the current literature and case reports concerning macrolides and, in particular, clarithromycin induced hearing loss.
  
  
  RESULTS
  A young pregnant woman presented with sensorineural hearing loss after clarithromycin intake. The subject's hearing returned to normal limits after drug discontinuation and short-term treatment with low dose steroids.
  
  
  CONCLUSIONS
  Newer macrolides are considered to be safer regarding ototoxic effects, and a few cases have been previously described. The present case adds to the body of knowledge concerning clarithromycin ototoxicity. Clinicians should be aware of this rare complication and a thorough otologic history should be established prior to macrolide administration. A baseline audiogram and close observation for patients at higher risk is suggested to identify patients with prior hearing loss and serve as baseline for future reference.
authors.affiliation: ENT Department of General Hospital of Nikea, Piraeus, Greece.
authors.forename: J K
authors.initials: JK
authors.lastname: Hajiioannou
authors.forename: V
authors.initials: V
authors.lastname: Florou
authors.forename: P
authors.initials: P
authors.lastname: Kousoulis
authors.forename: M
authors.initials: M
authors.lastname: Fragkos
authors.forename: E
authors.initials: E
authors.lastname: Moshovakis
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017291:Clarithromycin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006309:Hearing / Q000187:drug effects; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D012141:Respiratory Tract Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin