title: A 78-year-old woman with an acute eosinophilic gastroenteritis.
abstract: Eosinophil accumulation in the gastrointestinal tract is a common feature of numerous disorders including mainly parasitic infection, drug-induced allergic reactions, inflammatory bowel disease, and various connective tissue disorders. Digestive tissue eosinophilia requires thorough searching for secondary causes that may be specifically treated with antibiotics, dietary and drug elimination or immunosuppressive therapy. Frequency, prognosis and therapeutic implications must guide the diagnostic course. An acute eosinophilic gastroenteritis in a 78-year-old asthmatic woman receiving celecoxib is reported. She presented later with neurologic and cutaneous features and was finally treated by methylprednisolone and cyclophosphamide. The diagnostic approach leading to a Churg-Strauss syndrome (CSS) assertion is described. We discuss the pathogenesis, the management and the potential enhancing role of celecoxib in CSS gastrointestinal involvement.
authors.affiliation: Department of Internal Medicine and Infectious diseases, Laveran Military Teaching Hospital, 4, boulevard Laveran, BP 60149, 13384 Marseille cedex 13, France. emilie.javelle@gmail.com
authors.forename: Emilie
authors.initials: E
authors.lastname: Javelle
authors.forename: Guillaume
authors.initials: G
authors.lastname: Gasperini
authors.forename: Jean
authors.initials: J
authors.lastname: Mercier
authors.forename: Laure
authors.initials: L
authors.lastname: Luciano
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Sagui
authors.forename: Marie
authors.initials: M
authors.lastname: Soulier
authors.forename: Sebastien
authors.initials: S
authors.lastname: Kerebel
authors.forename: Patrick
authors.initials: P
authors.lastname: Lebougeant
authors.forename: Sylvain
authors.initials: S
authors.lastname: Molinier
authors.forename: Michel
authors.initials: M
authors.lastname: Guisset
authors.forename: Thierry
authors.initials: T
authors.lastname: Coton
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Morand
mesh_terms: D000208:Acute Disease; D000368:Aged; D015267:Churg-Strauss Syndrome / Q000150:complications / Q000175:diagnosis*; D004751:Enteritis / Q000209:etiology; D004802:Eosinophilia / Q000209:etiology; D005260:Female; D005756:Gastritis / Q000209:etiology; D006801:Humans