title: Prevalence of equine herpesvirus type 1 strains of neuropathogenic genotype in a major breeding area of Japan.
abstract: A single non-synonymous nucleotide substitution of guanine (G) for adenine (A) at position 2254 in the viral DNA polymerase gene (encoded by open reading frame [ORF] 30) of equine herpesvirus type 1 (EHV-1) has been significantly associated with neuropathogenic potential in strains of this virus. To estimate the prevalence of EHV-1 strains with the neuropathogenic genotype (ORF30 G(2254)) in the Hidaka district--a major horse breeding area in Japan--we analyzed the ORF30 genomic region in cases of EHV-1 infection in this area during the years 2001-2010. Of the 113 cases analyzed, 3 (2.7%) were induced by ORF30 G(2254) strains. This prevalence is lower than those observed in the U.S.A. (10.8-19.4%), Argentina (7.4%), France (24%), and Germany (10.6%).
authors.affiliation: Epizootic Research Center, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi 329–0412, Japan. koji_tsujimura@jra.go.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Tsujimura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oyama
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Katayama
authors.forename: Masanori
authors.initials: M
authors.lastname: Muranaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Bannai
authors.forename: Manabu
authors.initials: M
authors.lastname: Nemoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Kato
authors.forename: Tomio
authors.initials: T
authors.lastname: Matsumura
mesh_terms: D000034:Abortion, Veterinary; D000818:Animals; D001947:Breeding; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D004861:Herpesvirus 1, Equid / Q000235:genetics* / Q000302:isolation & purification*; D006734:Horse Diseases / Q000453:epidemiology / Q000821:virology*; D006736:Horses; D007564:Japan / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D013997:Time Factors