title: Moving in the right direction: how eukaryotic cells migrate along chemical gradients.
abstract: Many cells have the ability to grow or migrate towards chemical cues. Oriented growth and movement require detection of the external chemical gradient, transduction of signals, and reorganization of the cytoskeleton. Recent studies in Dictyostelium discoideum and mammalian neutrophils have revealed a complex signaling network that enables cells to migrate in chemical gradients.
authors.affiliation: The Department of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Huaqing
authors.initials: H
authors.lastname: Cai
authors.forename: Peter N
authors.initials: PN
authors.lastname: Devreotes
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D002630:Chemotactic Factors / Q000378:metabolism* / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D002630:Chemotactic Factors