title: Glycated haemoglobin: what is the diagnostic yield at shortened testing intervals?
abstract: The proportion of sequential HbA1c exceeding critical difference (diagnostic yield), where it is considered clinically significant change, was calculated for different testing intervals. 12% and 26% of repeat HbA1c exceeded the critical difference before 30 and 90 days testing intervals, respectively. Repeating HbA1c within 4 weeks has poor diagnostic yield and should be avoided.
authors.affiliation: Department of Laboratory Medicine, National University Hospital, Singapore. lohtp@yahoo.com
authors.forename: Tze Ping
authors.initials: TP
authors.lastname: Loh
authors.forename: Karen Mei Ling
authors.initials: KM
authors.lastname: Tan
authors.forename: Sharon
authors.initials: S
authors.lastname: Saw
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Sethi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012846:Singapore; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human