title: MOSFET-BJT hybrid mode of the gated lateral bipolar junction transistor for C-reactive protein detection.
abstract: In this study, we propose a novel biosensor based on a gated lateral bipolar junction transistor (BJT) for biomaterial detection. The gated lateral BJT can function as both a BJT and a metal-oxide-semiconductor field-effect transistor (MOSFET) with both the emitter and source, and the collector and drain, coupled. C-reactive protein (CRP), which is an important disease marker in clinical examinations, can be detected using the proposed device. In the MOSFET-BJT hybrid mode, the sensitivity, selectivity, and reproducibility of the gated lateral BJT for biosensors were evaluated in this study. According to the results, in the MOSFET-BJT hybrid mode, the gated lateral BJT shows good selectivity and reproducibility. Changes in the emitter (source) current of the device for CRP antigen detection were approximately 0.65, 0.72, and 0.80 μA/decade at base currents of -50, -30, and -10 μA, respectively. The proposed device has significant application in the detection of certain biomaterials that require a dilution process using a common biosensor, such as a MOSFET-based biosensor.
authors.affiliation: School of Electrical Engineering and Computer Science, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Heng
authors.initials: H
authors.lastname: Yuan
authors.forename: Hyurk-Choon
authors.initials: HC
authors.lastname: Kwon
authors.forename: Se-Hyuk
authors.initials: SH
authors.lastname: Yeom
authors.forename: Dae-Hyuk
authors.initials: DH
authors.lastname: Kwon
authors.forename: Shin-Won
authors.initials: SW
authors.lastname: Kang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D002097:C-Reactive Protein / Q000032:analysis*; D015203:Reproducibility of Results; D012666:Semiconductors; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance; D014173:Transistors, Electronic
chemical_list: D002097:C-Reactive Protein