title: Genetic susceptibility to juvenile idiopathic arthritis in Iranian children.
abstract: OBJECTIVE
  This study was comprised of Iranian children with oligoarthritis and rheumatoid factor negative (RF) polyarthritis subtypes of juvenile idiopathic arthritis (JIA) to determine the association of HLA-DRB1 alleles in Iran.
  
  
  METHODS
  HLA-DRB1 alleles were investigated in 33 Iranian children with oligoarthritis and RF negative polyarthritis JIA and compared with 45 healthy controls. HLA typing was performed by PCR with sequence specific primers in either of the two groups and followed by direct detection of HLA polymorphism by sequence analysis in patient group.
  
  
  RESULTS
  HLA-DRB1*11 was found to be the most frequent allele associated with oligoarthritis and RF negative polyarthritis JIA in Iran followed by HLA-DRB1*8. The frequencies of HLA-DRB1*04 and *13 were not significantly different in both groups.
  
  
  CONCLUSIONS
  We concluded that there was a significant difference in allele frequencies between patients and control group that may help in predicting the susceptibility to oligoarthritis and rheumatic factor negative polyarthritis JIA.
authors.affiliation: Faculty of Biological Sciences, Shahid Beheshti University, G.C., Tehran, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Farivar
authors.forename: Reza
authors.initials: R
authors.lastname: Shiari
authors.forename: Elham
authors.initials: E
authors.lastname: Hadi
mesh_terms: D001171:Arthritis, Juvenile / Q000235:genetics* / Q000276:immunology*; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D007492:Iran; D008297:Male
chemical_list: D059811:HLA-DRB1 Chains