title: How we mobilize haemopoietic stem cells.
abstract: Mobilization and collection of haemopoietic stem and progenitor cells (HSPC) is the cornerstone of autologous and allogeneic stem cell transplantation for a wide variety of haematological and some non-haematological malignancies. Centres providing this service face the challenge of optimizing the likelihood of successful collection of transplantable doses of cells, while maximizing the efficiency of the apheresis unit and minimizing the risk of toxicity as well as mobilization failure. Recent developments in the understanding of the molecular mechanisms of mobilization have led to the emergence of novel strategies for HSPC mobilization, which may assist in meeting these imperatives. The task for clinicians is how to incorporate the use of these strategies into practice, in the light of emerging evidence for efficacy and safety of these agents. Herein, the literature is reviewed, and a proposed algorithm for HSPC mobilization is presented.
authors.affiliation: Division of Cancer Medicine, Peter MacCallum Cancer Centre, The Royal Melbourne Hospital, Victoria, Australia.
authors.forename: K E
authors.initials: KE
authors.lastname: Herbert
authors.forename: J-P
authors.initials: JP
authors.lastname: Levesque
authors.forename: A K
authors.initials: AK
authors.lastname: Mills
authors.forename: D J
authors.initials: DJ
authors.lastname: Gottlieb
authors.forename: J
authors.initials: J
authors.lastname: Cooney
authors.forename: J
authors.initials: J
authors.lastname: Szer
authors.forename: J
authors.initials: J
authors.lastname: Rasko
authors.forename: L B
authors.initials: LB
authors.lastname: To
mesh_terms: D000818:Animals; D001781:Blood Component Removal / Q000379:methods / Q000592:standards; D001854:Bone Marrow Cells / Q000502:physiology; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods* / Q000592:standards; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000592:standards; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans
chemical_list: D016179:Granulocyte Colony-Stimulating Factor