title: [Effects of dimethyloxalyl glycine on hypoxic-ischemic brain damage in newborn rats].
abstract: OBJECTIVE
  To investigate the effects of dimethyloxalyl glycine on hypoxic-ischemic brain damage in newborn rats.
  
  
  METHODS
  Forty eight postnatal day 10 SD rats were divided into 3 groups, including sham surgery group, hypoxic-ischemic group and DMOG treated group. The brain tissues were collected at 4, 8, 24 and 72 hours after the hypoxic-ischemic treatment. The expressions of hypoxia inducible factor-1alpha (HIF-1alfa) protein and anti apoptoticprotein cleaved caspase 3 (CC3) were detected by immunohistochemistry. The apoptotic cells were detected by TUNEL staining.
  
  
  RESULTS
  The expression level of HIF-1alpha was significantly higher in DMOG treated group than in hypoxic-ischemic group. While the expression level of CC3 was lower and the number of tunel positive cells was fewer in DMOG treated group than that in hypoxic-ischemic group.
  
  
  CONCLUSIONS
  Dimethyloxalyl glycine may play a neuro-protective role in hypoxic-ischemic brain damage in newborn rats by stabilizing HIF-1alpha.
authors.affiliation: Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Qu
authors.forename: Yi
authors.initials: Y
authors.lastname: Qu
authors.forename: Feng-Yan
authors.initials: FY
authors.lastname: Zhao
authors.forename: Bin-Zhi
authors.initials: BZ
authors.lastname: Tang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: De-Zhi
authors.initials: DZ
authors.lastname: Mu
mesh_terms: D000600:Amino Acids, Dicarboxylic / Q000627:therapeutic use*; D000818:Animals; D000831:Animals, Newborn; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000600:Amino Acids, Dicarboxylic; D018696:Neuroprotective Agents; D011393:Procollagen-Proline Dioxygenase; C040947:oxalylglycine