title: [Study on resting-state default mode network in patients with posttraumatic stress disorder after the earthquake].
abstract: OBJECTIVE
  To explore the pathogenesis of posttraumatic stress disorder (PTSD) by studying default mode network during the resting state in patients with PTSD after homologous traumatic experience.
  
  
  METHODS
  Seventeen PTSD patients and 20 matched normal controls received the examnation of resting-state fMRI scanning. Left and right posterior cingulate cortex was regarded as seed region respectively, and the functional connectivity about whole brain was assessed by using resting-state functional connectivity analysis.
  
  
  RESULTS
  Compared with control group, the patients with PTSD showed that the brain area with decreased functional connectivity included left superior frontal gyrus and right fusiform gyrus, while the brain area with increased functional connectivity included right precuneus, right superior temporal gyrus and right middle temporal gyrus.
  
  
  CONCLUSIONS
  The brain default mode network of PTSD patients is abnormal in resting state. These abnormalities might be the neuropathological mechanisms of PTSD.
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Rui-Zhi
authors.initials: RZ
authors.lastname: Wu
authors.forename: Jun-Ran
authors.initials: JR
authors.lastname: Zhang
authors.forename: Chang-Jian
authors.initials: CJ
authors.lastname: Qiu
authors.forename: Ya-Jing
authors.initials: YJ
authors.lastname: Meng
authors.forename: Hong-Ru
authors.initials: HR
authors.lastname: Zhu
authors.forename: Qi-Yong
authors.initials: QY
authors.lastname: Gong
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China; D004190:Disasters; D055866:Earthquakes; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology*; D055815:Young Adult