title: Organ printing: the future of bone regeneration?
abstract: In engineered bone grafts, the combined actions of bone-forming cells, matrix and bioactive stimuli determine the eventual performance of the implant. The current notion is that well-built 3D constructs include the biological elements that recapitulate native bone tissue structure to achieve bone formation once implanted. The relatively new technology of organ/tissue printing now enables the accurate 3D organization of the components that are important for bone formation and also addresses issues, such as graft porosity and vascularization. Bone printing is seen as a great promise, because it combines rapid prototyping technology to produce a scaffold of the desired shape and internal structure with incorporation of multiple living cell types that can form the bone tissue once implanted.
authors.affiliation: Department of Orthopaedics, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
authors.forename: Natalja E
authors.initials: NE
authors.lastname: Fedorovich
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Alblas
authors.forename: Wim E
authors.initials: WE
authors.lastname: Hennink
authors.forename: F Cumhur
authors.initials: FC
authors.lastname: Oner
authors.forename: Wouter J A
authors.initials: WJ
authors.lastname: Dhert
mesh_terms: D000818:Animals; D001846:Bone Development; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods*; D006801:Humans; D009924:Organ Culture Techniques / Q000379:methods