title: Voice quality after treatment of early glottic carcinoma.
abstract: OBJECTIVE
  Increasing incidence of laryngeal carcinoma and advancement in diagnostics and therapy methods, have led to constant exploration in that field. Early glottic carcinoma can be treated successfully with several procedures: cordectomy through laryngofissure, laser cordectomy, and radiotherapy. Our objective was to assess the voice quality after these different modalities of treatment.
  
  
  METHODS
  Prospective controlled study with 69 patients, treated in a 1-year period for glottic Tis and T1a carcinoma at the tertiary medical centre.
  
  
  METHODS
  Nineteen of our patients were treated endoscopically with CO(2) laser (types III-IV cordectomy according to recommended European Laryngological Society classification of endoscopic cordectomies). Thirty-five patients underwent cordectomy through laryngofissure, 15 patients had radiotherapy. Multidimensional computer analysis of voice and speech was conducted 1, 6, and 12 months after the treatment. Three programs included 14 parameters, which were observed.
  
  
  RESULTS
  While comparing the parameters between the groups, there were significant differences in the values of fundamental frequency (Hz), jitter (%), normalized noise energy (dB), standard deviation of fundamental frequency (Hz), percent silent time (%), and sound-pressure level in the different follow-up periods (P<0.05).
  
  
  CONCLUSIONS
  In the long run, patients treated with radiotherapy show better voice quality in comparison with other two groups.
authors.affiliation: Institute of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Belgrade, Serbia. anajotic@yahoo.com
authors.forename: Ana
authors.initials: A
authors.lastname: Jotic
authors.forename: Predrag
authors.initials: P
authors.lastname: Stankovic
authors.forename: Snezana
authors.initials: S
authors.lastname: Jesic
authors.forename: Jovica
authors.initials: J
authors.lastname: Milovanovic
authors.forename: Milena
authors.initials: M
authors.lastname: Stojanovic
authors.forename: Vojko
authors.initials: V
authors.lastname: Djukic
mesh_terms: D002277:Carcinoma / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D055088:Early Detection of Cancer; D005260:Female; D005931:Glottis / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D007825:Laryngectomy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D007828:Laryngoscopy / Q000009:adverse effects / Q000295:instrumentation; D053685:Laser Therapy / Q000009:adverse effects / Q000295:instrumentation; D054020:Lasers, Gas; D008297:Male; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011832:Radiation Injuries / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D055771:Serbia; D012815:Signal Processing, Computer-Assisted; D013061:Speech Acoustics; D013068:Speech Production Measurement; D013997:Time Factors; D016896:Treatment Outcome; D014832:Voice Disorders / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D014833:Voice Quality / Q000528:radiation effects; D014834:Voice Training