title: Levels of soluble endothelial selectin in umbilical cord serum are influenced by gestational age and histological chorioamnionitis, but not by pre-eclampsia.
abstract: OBJECTIVE
  The aim of this study was to examine the factors that influence soluble endothelial selectin (sE-selectin) levels in umbilical cord serum.
  
  
  METHODS
  sE-selectin levels in umbilical cord serum were measured in 144 patients using enzyme-linked immunosorbent assay. We examined the association of sE-selectin levels with gestational age, pre-eclampsia (PE), histological chorioamnionitis (HCAM), preterm premature rupture of membranes, magnesium sulfate use, birthweight, and placental weight.
  
  
  RESULTS
  A significant positive correlation was observed between sE-selectin levels and gestational age in the patients who had neither PE nor HCAM (r = 0.559, P < 0.0001). This statistically positive correlation persisted in patients with PE without HCAM (n = 25, r = 0.644, P < 0.001), but not in patients with HCAM without PE (n = 58, r = 0.102, P = 0.448). In matched gestational age analysis, sE-selectin levels were increased in the presence of HCAM (P = 0.0006), but were not influenced by the presence of PE (P = 0.127), preterm premature rupture of membranes (P = 0.352) or magnesium sulfate use (P = 0.337).
  
  
  CONCLUSIONS
  sE-selectin levels in umbilical cord serum were positively correlated with gestational weeks. sE-selectin levels in umbilical cord serum were higher in mothers with HCAM but not with PE, when compared with gestational-age-matched controls.
authors.affiliation: Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan. mitani@obgy.twmu.ac.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Mitani
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Etsuko
authors.initials: E
authors.lastname: Shimada
authors.forename: Aiko
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Yoshika
authors.initials: Y
authors.lastname: Akizawa
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kawamichi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Makino
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsui
mesh_terms: D000328:Adult; D002821:Chorioamnionitis / Q000378:metabolism*; D019040:E-Selectin / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010920:Placenta / Q000378:metabolism; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D019040:E-Selectin