title: A periadventitial sirolimus-releasing mesh decreased intimal hyperplasia in a rabbit model.
abstract: Autologous vein grafts used as aortocoronary bypasses are often prone to intimal hyperplasia, which results in stenosis and occlusion of the vein. The aim of this study was to prevent intimal hyperplasia using a newly developed perivascular system with sustained release of sirolimus. This system of controlled drug release consists of a polyester mesh coated with a copolymer of L-lactic acid and epsilon-caprolactone that releases sirolimus. The mesh is intended for wrapping around the vein graft during surgery. The mesh releasing sirolimus was implanted in periadventitial position onto arteria carotis communis of rabbits, and neointimal hyperplasia was then assessed. We found that implanted sirolimus-releasing meshes reduced intima thickness by 47+/-10 % compared to a vein graft after 3 weeks. The pure polyester mesh decreased vein intima thickness by 35+/-9 %. Thus, our periadventitial system for controlled release of sirolimus prevented the development of intimal hyperplasia in autologous vein grafts in vivo in rabbits. A perivascularly applied mesh releasing sirolimus is a promising device for preventing stenosis of autologous vein grafts.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: I
authors.initials: I
authors.lastname: Skalský
authors.forename: E
authors.initials: E
authors.lastname: Filová
authors.forename: O
authors.initials: O
authors.lastname: Szárszoi
authors.forename: M
authors.initials: M
authors.lastname: Pařízek
authors.forename: A
authors.initials: A
authors.lastname: Lytvynets
authors.forename: J
authors.initials: J
authors.lastname: Malušková
authors.forename: A
authors.initials: A
authors.lastname: Lodererová
authors.forename: E
authors.initials: E
authors.lastname: Brynda
authors.forename: V
authors.initials: V
authors.lastname: Lisá
authors.forename: Z
authors.initials: Z
authors.lastname: Burdíková
authors.forename: M
authors.initials: M
authors.lastname: Capek
authors.forename: J
authors.initials: J
authors.lastname: Pirk
authors.forename: L
authors.initials: L
authors.lastname: Bačáková
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004337:Drug Carriers; D006083:Graft Occlusion, Vascular / Q000473:pathology / Q000517:prevention & control*; D006965:Hyperplasia / Q000517:prevention & control; D007601:Jugular Veins / Q000187:drug effects / Q000473:pathology; D011091:Polyesters; D011817:Rabbits; D020123:Sirolimus / Q000737:chemistry / Q000494:pharmacology*; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology
chemical_list: D002317:Cardiovascular Agents; D004337:Drug Carriers; D011091:Polyesters; C062968:lactide-caprolactone copolymer; D020123:Sirolimus