title: Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children.
abstract: OBJECTIVE
  To find the best lead exposure assessment marker for children.
  
  
  METHODS
  We recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level.
  
  
  RESULTS
  Nine of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score.
  
  
  CONCLUSIONS
  Lead exposure at younger age significantly impacts a child's later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.
authors.affiliation: Purdue University, School of Health Sciences, West Lafayette, IN, USA. hnie@purdue.edu
authors.forename: Linda H
authors.initials: LH
authors.lastname: Nie
authors.forename: Robert O
authors.initials: RO
authors.lastname: Wright
authors.forename: David C
authors.initials: DC
authors.lastname: Bellinger
authors.forename: Javed
authors.initials: J
authors.lastname: Hussain
authors.forename: Chitra
authors.initials: C
authors.lastname: Amarasiriwardena
authors.forename: David R
authors.initials: DR
authors.lastname: Chettle
authors.forename: Ana
authors.initials: A
authors.lastname: Pejović-Milić
authors.forename: Alan
authors.initials: A
authors.lastname: Woolf
authors.forename: Michael
authors.initials: M
authors.lastname: Shannon
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D001842:Bone and Bones / Q000737:chemistry; D002648:Child; D002658:Developmental Disabilities / Q000097:blood* / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D007854:Lead / Q000009:adverse effects / Q000097:blood*; D020264:Lead Poisoning, Nervous System, Childhood / Q000097:blood* / Q000503:physiopathology; D008297:Male; D009420:Nervous System / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D011446:Prospective Studies; D014481:United States
chemical_list: D015415:Biomarkers; D007854:Lead