title: The association between ACE polymorphism and risk of colorectal cancer in a Chinese population.
abstract: OBJECTIVE
  Angiotensin I-converting enzyme (ACE) plays crucial roles not only in the regulation of circulatory homeostasis but also in the pathology of carcinomas. An insertion-deletion (I/D) polymorphism in intron 16 of ACE gene was identified to be functional. We aimed to investigate the association between ACE I/D polymorphism and risk of colorectal cancer (CRC).
  
  
  METHODS
  Using genomic DNA from 241 CRC patients and 299 control subjects, we genotyped the ACE I/D polymorphism using a polymerase chain reaction analysis.
  
  
  RESULTS
  We found that patients carrying the D allele were associated with an increased risk of developing poorly differentiated cancer and metastasis compared with those carrying the I allele (OR=1.54, 95%CI, 1.04-2.28; OR=1.56, 95%CI, 1.08-2.26, respectively), although no significant association was observed between cases and controls in overall analysis.
  
  
  CONCLUSIONS
  These findings indicate that the ACE I/D polymorphism is likely to play a role in CRC progression.
authors.affiliation: The Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130031, PR China.
authors.forename: Song-Yan
authors.initials: SY
authors.lastname: Liu
authors.forename: Xiutian
authors.initials: X
authors.lastname: Sima
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A