title: Brooding rumination and risk for depressive disorders in children of depressed mothers.
abstract: The goal of the current study was to examine the role of brooding rumination in children at risk for depression. We found that children of mothers with a history of major depression exhibited higher levels of brooding rumination than did children of mothers with no depression history. Examining potential mechanisms of this risk, we found no evidence for shared genetic influences (BDNF or 5-HTTLPR) or modeling of mothers' rumination. However, we did find that children with a history of prior depressive disorders exhibited higher current levels of brooding rumination than children with no depression history. Importantly, children's brooding predicted prospective onsets of new depressive episodes over a 20-month follow-up even when we statistically controlled for depressive symptom levels at the initial assessment, suggesting that the predictive effect of brooding rumination in children was not due simply to co-occurring depressive symptoms.
authors.affiliation: Binghamton University (SUNY), Binghamton, NY, USA. bgibb@binghamton.edu
authors.forename: Brandon E
authors.initials: BE
authors.lastname: Gibb
authors.forename: Marie
authors.initials: M
authors.lastname: Grassia
authors.forename: Lindsey B
authors.initials: LB
authors.lastname: Stone
authors.forename: Dorothy J
authors.initials: DJ
authors.lastname: Uhrlass
authors.forename: John E
authors.initials: JE
authors.lastname: McGeary
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology*; D003866:Depressive Disorder / Q000235:genetics / Q000523:psychology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009035:Mothers / Q000523:psychology*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D011795:Surveys and Questionnaires; D013850:Thinking
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins