title: Hospital-based surveillance of rotavirus gastroenteritis in the era of limited vaccine uptake through the private sector.
abstract: To investigate possible impact of limited vaccine uptake by the private sector since 2007, a prospective observational study included all children <5 years hospitalized for acute gastroenteritis (AGE) in a Tertiary Care Hospital between 09/2006 and 08/2010. Rotavirus (RV) antigen was detected in stools by a rapid immunochromatographic test and genotype analysis was performed on positive samples by RT-PCR. Compared to 2006-2008, the likelihood of rotavirus infection was significantly reduced among children hospitalized for AGE in 2008-2010 (OR 0.64; 95%CI: 0.49-0.84, p<0.001). This was mainly due to the reduction of RVGE cases in infants 0-11 months (p=0.035). Moreover, RVGE cases as well as the rate of RVGE/10,000 hospitalized children significantly decreased (p=0.009 and p=0.010 respectively). No children with rotavirus gastroenteritis (RVGE) had received any vaccine dose. G4P [8] was the most common genotype (64/90). In conclusion, this study indicates that even low RV vaccination coverage may have significant effect.
authors.affiliation: Vaccine Unit, VIANEX/Sanofi Pasteur MSD, Athens, Greece. gtrim@otenet.gr
authors.forename: Georgios
authors.initials: G
authors.lastname: Trimis
authors.forename: Ioanna
authors.initials: I
authors.lastname: Koutsoumbari
authors.forename: Christine
authors.initials: C
authors.lastname: Kottaridi
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Palaiologou
authors.forename: Efstathia
authors.initials: E
authors.lastname: Assimakopoulou
authors.forename: Aris
authors.initials: A
authors.lastname: Spathis
authors.forename: Evaggelia
authors.initials: E
authors.lastname: Lebessi
authors.forename: Andreas
authors.initials: A
authors.lastname: Konstantopoulos
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kafetzis
authors.forename: Petros
authors.initials: P
authors.lastname: Karakitsos
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Papaevangelou
mesh_terms: D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012401:Rotavirus / Q000276:immunology; D012400:Rotavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D022243:Rotavirus Vaccines; D014611:Vaccination
chemical_list: D022243:Rotavirus Vaccines