title: Cardiac myxoma with glandular differentiation: an immunohistochemical and ultrastructural study.
abstract: A case of cardiac myxoma with glandular differentiation is reported. The patient did not have elements of the Carney triad or syndrome. The tumor was mainly composed of characteristic stellate cells in a focally collagenized, myxoid stroma, along with aggregates of glandular-forming epithelial cells, with mucin-containing intra- and intercellular lumina. Ultrastructurally, these gland spaces displayed short, straight microvilli and junctional complexes. The epithelial cells were positive for cytokeratin 7 and negative for cytokeratin 20. Calretinin was positive in the stellate cells and negative in the epithelial component. The potential origin from pluripotent mesenchymal cells or from seeded stem cells is hypothesized for glandular differentiation in myxomas. Further studies are required to unravel the relationship between stellate cells and the diverse heterologous components reported in these tumors.
authors.affiliation: Hospital del Mar, Universitat Pompeu Fabra, Barcelona, Spain. jlloreta@hospitaldelmar.cat
authors.forename: Josep
authors.initials: J
authors.lastname: Lloreta
authors.forename: Núria
authors.initials: N
authors.lastname: Juanpere
authors.forename: Anna
authors.initials: A
authors.lastname: Riverola
authors.forename: Daniel
authors.initials: D
authors.lastname: Dallari
authors.forename: Maria Angels
authors.initials: MA
authors.lastname: Cañas
authors.forename: Lara
authors.initials: L
authors.lastname: Pijuan
authors.forename: Teresa
authors.initials: T
authors.lastname: Baró
authors.forename: Pilar
authors.initials: P
authors.lastname: García
authors.forename: Sergi
authors.initials: S
authors.lastname: Serrano
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D064032:Calbindin 2; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000737:chemistry / Q000648:ultrastructure; D005260:Female; D006338:Heart Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D053554:Keratin-20 / Q000032:analysis; D053552:Keratin-7 / Q000032:analysis; D059630:Mesenchymal Stem Cells / Q000737:chemistry / Q000648:ultrastructure; D008854:Microscopy, Electron; D009232:Myxoma / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery / Q000648:ultrastructure; D009375:Neoplasms, Glandular and Epithelial / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery / Q000648:ultrastructure; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000648:ultrastructure; D011237:Predictive Value of Tests; D064030:S100 Calcium Binding Protein G / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; C576764:CALB2 protein, human; D064032:Calbindin 2; C507499:KRT20 protein, human; C507497:KRT7 protein, human; D053554:Keratin-20; D053552:Keratin-7; D064030:S100 Calcium Binding Protein G