title: Design, synthesis, and drug solubilising properties of the first folate-calix[4]arene conjugate.
abstract: The first example of a folate-calix[4]arene conjugate was designed and synthesized via microwave-assisted click chemistry. In PBS medium at physiological pH, the conjugate formed soluble aggregates and showed the capability to improve the water-solubility of a hydrophobic drug model, such as indomethacin.
authors.affiliation: Consiglio Nazionale delle Ricerche, Istituto di Chimica Biomolecolare, Via Paolo Gaifami 18, 95126, Catania, Italy. grazia.consoli@icb.cnr.it
authors.forename: Grazia M L
authors.initials: GM
authors.lastname: Consoli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Granata
authors.forename: Corrada
authors.initials: C
authors.lastname: Geraci
mesh_terms: D047250:Calixarenes / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D057930:Click Chemistry; D015195:Drug Design; D005492:Folic Acid / Q000737:chemistry*; D007213:Indomethacin / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D012995:Solubility; D013237:Stereoisomerism
chemical_list: D010636:Phenols; C121325:calix(4)arene; D047250:Calixarenes; D005492:Folic Acid; D007213:Indomethacin