title: MicroRNA-451 regulates p38 MAPK signaling by targeting of Ywhaz and suppresses the mesangial hypertrophy in early diabetic nephropathy.
abstract: Diabetic nephropathy (DN) is a major diabetic complication. However, the initiating molecular events triggering DN are unknown. In this study we focused on microRNA-451 (miR-451), which is downregulated during early DN. We found that miR-451 negatively regulated the expression of Ywhaz through Ywhaz 3'UTR and that Ywhaz was required for the miR-451-mediated downregulation of p38 MAPK signalling. Moreover, over-expression of miR-451 inhibits glomerular mesangial cell proliferation in vitro and in vivo. These findings suggest that the growth-inhibitory effect of miR-451 may be explained in part by miR-451-induced suppression of Ywhaz and p38 MAPK signalling, providing evidence for the potential role of miR-451 in early DN.
authors.affiliation: Department of Cell Biology and Medical Genetics, Chongqing Medical University, No. 1, Medical College Road, Chongqing, China. zhangzheng92@163.com
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Luo
authors.forename: Songtao
authors.initials: S
authors.lastname: Ding
authors.forename: Junxia
authors.initials: J
authors.lastname: Chen
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: He
authors.initials: H
authors.lastname: Zha
authors.forename: Li
authors.initials: L
authors.lastname: Yao
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: He
authors.forename: Huimin
authors.initials: H
authors.lastname: Peng
mesh_terms: D048948:14-3-3 Proteins / Q000235:genetics* / Q000378:metabolism*; D020413:3' Untranslated Regions; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D049109:Cell Proliferation; D017124:Conserved Sequence; D003928:Diabetic Nephropathies / Q000235:genetics* / Q000378:metabolism; D020935:MAP Kinase Signaling System / Q000235:genetics; D008297:Male; D050527:Mesangial Cells / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D048948:14-3-3 Proteins; D020413:3' Untranslated Regions; D035683:MicroRNAs; C550758:Mirn451 microRNA, mouse; D048051:p38 Mitogen-Activated Protein Kinases