title: [Studies on the chemical constituents of Coleus forskohlii transplanted in Tongcheng and their antitumor activity].
abstract: OBJECTIVE
  To study the chemical constituents of Coleus forskohlii.
  
  
  METHODS
  Isolation and purification were carried out by silica gel column chromatographic and Toyopearl HW-40F. Compounds were identified and elucidated by spectral and chemical methods.
  
  
  RESULTS
  Seven compounds were obtained from ethyl acetate extract fraction. Their structures were identified as lupeol (1), oleanolic acid (2), uvalo(3), beta-sitosterol (4), colonic acid (5), demethylcryptojaponol (6), coleolic acid (7). Compounds 1, 2, 6, 7 showed obviously antitumor activity.
  
  
  CONCLUSIONS
  Compound 1 and 3 are isolated from the genus for the first time. Moreover, compound 1 is firstly found to have antitumor activity from the plants.
authors.affiliation: Xiang Fan Hospital of Traditional Chinese Medicine, Xiangfan 441000, China.
authors.forename: De-Hong
authors.initials: DH
authors.lastname: Huang
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Yang
authors.forename: Lun-Qiang
authors.initials: LQ
authors.lastname: Ai
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.forename: He-Zhen
authors.initials: HZ
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D031330:Coleus / Q000737:chemistry* / Q000254:growth & development; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry / Q000254:growth & development; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000094042:Lupanes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C010480:lupeol; D000094042:Lupanes; C013330:uvaol