title: Nilotinib is effective in imatinib and sunitinib resistant GIST: a case report.
abstract: We report on the case of a 65-year-old male patient who had an imatinib- and sunitinib-resistant gastro-intestinal stromal tumor. Partial response was achieved with nilotinib treatment given in a compassionate-use program. Efficacy and tolerability of nilotinib in patients with refractory gastrointestinal stromal tumor are briefly discussed.
authors.affiliation: Department of Medical Oncology, Hacettepe University, Institute of Oncology, Ankara, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Dizdar
authors.forename: Suayib
authors.initials: S
authors.lastname: Yalcin
mesh_terms: D000368:Aged; D001549:Benzamides; D019008:Drug Resistance, Neoplasm; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use*; D000077210:Sunitinib
chemical_list: D001549:Benzamides; D007211:Indoles; D010879:Piperazines; D011743:Pyrimidines; D011758:Pyrroles; D000068877:Imatinib Mesylate; C498826:nilotinib; D000077210:Sunitinib