title: [Clinical significance of cytochrome P450 genetic polymorphism--part I. Enzymatic system of cytochrome P450 and cytochrome P450 1A2].
abstract: Inter-individual variability in drug response is a major clinical problem. Much of the variability has been observed in drug metabolism, particularly in the enzymes of cytochrome P450. Genetic polymorphism in these enzymes may influence a patient's response to commonly prescribed drugs. The first part of this review describes the enzymatic system of cytochrome P450 and further focuses on the influence of genetic polymorphism of cytochrome P450 1A2 on drug effect.
authors.affiliation: Ostravská Univerzita v Ostrave, Lékarská fakulta, Ustav klinické farmakologie FN, Ostrava. jana.duricova@fno.cz
authors.forename: Jana
authors.initials: J
authors.lastname: Duricová
authors.forename: Milan
authors.initials: M
authors.lastname: Grundmann
mesh_terms: D001711:Biotransformation / Q000235:genetics*; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic
chemical_list: D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D019388:Cytochrome P-450 CYP1A2