title: An observational pilot study of CSF diversion in subarachnoid haemorrhage.
abstract: BACKGROUND
  A primary focus of hospital treatment following admission for subarachnoid haemorrhage (SAH) is a prevention of cerebral artery vasospasm, which may result in ischaemic stroke. Intraventricular catheter (IVC) insertion to facilitate cerebral spinal fluid (CSF) drainage and intracranial pressure (ICP) monitoring may reduce the incidence or severity of vasospasm, but insufficient evidence exists from which clinicians may determine the best practice of CSF management.
  
  
  OBJECTIVE
  The aim of this study was to provide the pilot data to explore the impact of different methods of CSF drainage on outcomes in patients with SAH.
  
  
  METHODS
  In this non-randomized observational study, patients diagnosed with SAH who had ICP monitoring in situ were prospectively enrolled. Group assignment was determined by the method of external ventricular drainage (EVD) management prescribed by the attending physician prior to enrollment.
  
  
  RESULTS
  The 37 subjects were disproportionately divided: open-EVD group (N = 24) and monitor-ICP group (N = 13). There were no statistically significant differences by group assignment with respect to vasospasm, length of stay (LOS), highest average ICP, total CSF drained and disability upon discharge between groups.
  
  
  CONCLUSIONS
  Although not significant, our results show that the monitor-ICP group trended towards improved clinical outcomes. These results provide sufficient equipoise to support further research in ICP management in patients with SAH using a randomized clinical trial.
  
  
  CONCLUSIONS
  This study provides a solid foundation for the development of a randomized trial exploring two different methods of ICP monitoring and CSF diversion during the acute phase of care following aneurysm rupture.
authors.affiliation: Neuroscience Critical Care Unit, Duke University Medical Center, Durham, NC, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Amato
authors.forename: Gavin W
authors.initials: GW
authors.lastname: Britz
authors.forename: Michael L
authors.initials: ML
authors.lastname: James
authors.forename: Carmelo
authors.initials: C
authors.lastname: Graffagnino
authors.forename: Ali R
authors.initials: AR
authors.lastname: Zomorodi
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Zomorodi
authors.forename: DaiWai M
authors.initials: DM
authors.lastname: Olson
mesh_terms: D002557:Cerebrospinal Fluid Shunts / Q000295:instrumentation / Q000379:methods; D004322:Drainage / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D010865:Pilot Projects; D011446:Prospective Studies; D013345:Subarachnoid Hemorrhage / Q000628:therapy*; D016896:Treatment Outcome; D020301:Vasospasm, Intracranial / Q000517:prevention & control