title: Notch signaling: simplicity in design, versatility in function.
abstract: Notch signaling is evolutionarily conserved and operates in many cell types and at various stages during development. Notch signaling must therefore be able to generate appropriate signaling outputs in a variety of cellular contexts. This need for versatility in Notch signaling is in apparent contrast to the simple molecular design of the core pathway. Here, we review recent studies in nematodes, Drosophila and vertebrate systems that begin to shed light on how versatility in Notch signaling output is generated, how signal strength is modulated, and how cross-talk between the Notch pathway and other intracellular signaling systems, such as the Wnt, hypoxia and BMP pathways, contributes to signaling diversity.
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
authors.forename: Emma R
authors.initials: ER
authors.lastname: Andersson
authors.forename: Rickard
authors.initials: R
authors.lastname: Sandberg
authors.forename: Urban
authors.initials: U
authors.lastname: Lendahl
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D014714:Vertebrates / Q000235:genetics / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D051880:Receptors, Notch