title: Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver.
abstract: Titanate nanofibers containing silver have been demonstrated through the experiments reported herein to have effective antifungal and antiproliferative activities in the presence of UV light. The titanate nanofibers containing silver can be fabricated by means of ion exchange followed by a topochemical process in an environment suitable for reductive reactions. Excellent antibacterial, antifungal, and antiproliferative activities could be demonstrated by both Ag₂Ti₅O₁₁ · xH₂O and Ag/titanate (UV light irradiation) due to their unique structures and compositions, which have photocatalytic activities to generate reactive oxygen species and capabilities to continuously release the silver ions. Therefore these materials have the potential to produce a membrane for the treatment of superficial malignant tumor, esophageal cancer, or cervical carcinoma. They may also hold utility if incorporated into a coating on stents in moderate and advanced stage esophageal carcinoma or for endoscopic retrograde biliary drainage. These approaches may significantly reduce infections, inhibit tumor growth, and importantly, improve quality of life and prolong survival time for patients with tumors.
authors.affiliation: Department of Traditional Chinese Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Yong Hua
authors.initials: YH
authors.lastname: Su
authors.forename: Zi Fei
authors.initials: ZF
authors.lastname: Yin
authors.forename: Hai Liang
authors.initials: HL
authors.lastname: Xin
authors.forename: Hui Qing
authors.initials: HQ
authors.lastname: Zhang
authors.forename: Jia Yu
authors.initials: JY
authors.lastname: Sheng
authors.forename: Yan Long
authors.initials: YL
authors.lastname: Yang
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Chang Quan
authors.initials: CQ
authors.lastname: Ling
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D057139:Nanofibers / Q000737:chemistry*; D055668:Photochemical Processes; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013816:Thermodynamics; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D000890:Anti-Infective Agents; D012834:Silver; D014025:Titanium