title: Malignant solitary fibrous tumor of the thyroid gland: report of a case and review of the literature.
abstract: Solitary fibrous tumors of the thyroid gland (T-SFT) are rarely described, with only 21 cases being reported in the English literatures, all showing benign clinical characteristics. We herein present a 76-year-old woman presenting with a 3-month history of rapidly enlarging neck masses and the CT showed masses with partial calcification in the right thyroid lobe. We performed right hemithyroidectomy and isthmectomy with negative margin under general anesthesia. Histologically, the masses consisted of pleomorphic spindle cells with high mitoses and collagen bands. Immunohistochemically, the tumor cells showed positive reactions for CD34, vimentin and bcl-2, then a diagnosis of malignant solitary fibrous tumor of the right thyroid was made. Six months postoperatively, the CT showed the recurrence of the thyroid tumor and the presence of many nodules of varying sizes throughout bilateral pulmonary lobes. To our knowledge, this is the first case of malignant solitary fibrous tumor of the thyroid gland (T-SFT) with local recurrence and pulmonary metastasis and T-SFT must be considered in the differential diagnosis of spindle cells lesions in the thyroid gland. Correct diagnosis of the malignant T-SFT plays an important role in choosing appropriate therapeutic strategies and long-term follow-up is also extremely essential for these patients.
authors.affiliation: Department of General Surgery, Qilu Hospital, Shandong University, Ji'nan, China.
authors.forename: Shanglei
authors.initials: S
authors.lastname: Ning
authors.forename: Xie
authors.initials: X
authors.lastname: Song
authors.forename: Lei
authors.initials: L
authors.lastname: Xiang
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Cheng
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Chen
mesh_terms: D000199:Actins / Q000378:metabolism; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary*; D009364:Neoplasm Recurrence, Local; D054364:Solitary Fibrous Tumors / Q000378:metabolism / Q000556:secondary*; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology*; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed
chemical_list: D000199:Actins; D018952:Antigens, CD34