title: Irrelevance between the induction of anti-Campylobacter humoral response by a bacterin and the lack of protection against homologous challenge in Japanese Jidori chickens.
abstract: On-farm vaccination of chickens against Campylobacter jejuni is considered a potentially effective countermeasure to decrease campylobacteriosis via consumption of contaminated chicken meat, but is not yet available. In this study, 2 groups of Jidori chicks were immunized subcutaneously with a formalin-killed C. jejuni with 2 different adjuvants. Other chicks served as the unvaccinated control group. Both vaccines induced high levels of anti-Campylobacter IgG but did not decrease bacterial excretion in cecal droppings and bacterial load in the liver and spleen after oral challenge with 10(5) CFU of the homologous strain. Further study is needed to address the observed irrelevance and to develop a novel effective vaccine against C. jejuni.
authors.affiliation: Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine, Towada, Aomori, Japan. okamuram@vmas.kitasato-u.ac.jp
authors.forename: Masashi
authors.initials: M
authors.lastname: Okamura
authors.forename: Ayumi
authors.initials: A
authors.lastname: Tominaga
authors.forename: Michihiro
authors.initials: M
authors.lastname: Ueda
authors.forename: Rumiko
authors.initials: R
authors.lastname: Ohshima
authors.forename: Masahide
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Mari
authors.initials: M
authors.lastname: Tsukada
authors.forename: Eriko
authors.initials: E
authors.lastname: Yokoyama
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Takehara
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Deguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Honda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines / Q000276:immunology*; D002167:Campylobacter / Q000145:classification / Q000276:immunology*; D002169:Campylobacter Infections / Q000517:prevention & control / Q000662:veterinary*; D002645:Chickens; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D007074:Immunoglobulin G / Q000097:blood; D011201:Poultry Diseases / Q000517:prevention & control*
chemical_list: D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007074:Immunoglobulin G