title: Inhibitory effect of carboxymethylpachymaran on cyclophosphamide-induced oxidative stress in mice.
abstract: The aim of the present study was to investigate the immunomodulatory effect and antioxidant activity of carboxymethylpachymaran on cyclophosphamide-induced immunosuppression in mice in vivo. The results showed that carboxymethylpachymaran could be used to overcome the cyclophosphamide-induced immunosuppression in mice. Moreover, it significantly increased the thymus and spleen indices, lysozyme, catalase and superoxidase dismutase activities, and total antioxidant capacity. In contrast, it decreased xanthine oxidase activity and malondialdehyde levels. The results indicated that carboxymethylpachymaran might play an important role in the prevention of oxidative damage in the immunological system.
authors.affiliation: College of Animal Science and Technology, Guangxi University, Nanning, PR China.
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Wei
authors.forename: Ting-Jun
authors.initials: TJ
authors.lastname: Hu
authors.forename: Jiong-Ran
authors.initials: JR
authors.lastname: Chen
authors.forename: Ying-Yi
authors.initials: YY
authors.lastname: Wei
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D005260:Female; D005936:Glucans / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009113:Muramidase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D013154:Spleen / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005936:Glucans; C568908:carboxymethylpachymaran; D008315:Malondialdehyde; C003033:pachymaran; D003520:Cyclophosphamide; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D009113:Muramidase