title: Cytogenetic toxicity of Aloe vera (a medicinal plant).
abstract: The cytogenetic toxicity of the crude leaf extract of Aloe vera, a medicinal plant, was evaluated in two test systems, onion and Swiss albino mice, using their root tip meristematic and bone marrow cells, respectively. No significant increase in structural abnormalities in chromosomes was observed, but a marked increase in cells with chromosome-number anomalies was found. The extract, however, significantly increased the mitotic index of both cell types.
authors.affiliation: Department of Botany, Patna University, Patna, India.
authors.forename: Anjana
authors.initials: A
authors.lastname: Verma
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Amod
authors.initials: A
authors.lastname: Kumar
authors.forename: Parimal K
authors.initials: PK
authors.lastname: Khan
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism; D002869:Chromosome Aberrations / Q000139:chemically induced; D005260:Female; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D019697:Onions / Q000737:chemistry; D010936:Plant Extracts / Q000633:toxicity*; D018515:Plant Leaves
chemical_list: D009153:Mutagens; D010936:Plant Extracts