title: [A case of carcinoma associated with anal fistula resected after preoperative chemoradiotherapy].
abstract: A 66-year-old man with a 39-year history of anal fistula was admitted to our hospital for anal pain and bleeding. Fistulectomy was carried out for anal fistula. Histological examination of the specimen revealed carcinoma associated with anal fistula. A computed tomography showed that the tumor had invaded the prostate. Therefore, preoperative chemoradiotherapy(S-1 plus radiation 40 Gy/body)for locally advanced cancer was performed. Magnetic resonance imaging showed that the boundary between the tumor and the prostate was unclear, but we performed an abdominoperineal resection and the prostate was fully preserved. Histopathologically, no cancer cell existed on the surgical margin. The histological effect of chemoradiotherapy was judged as grade 2. This case suggested that surgical treatment combined with preoperative chemoradiotherapy may be effective for locally advanced carcinoma associated with anal fistula, in which preservation of adjacent organs is considered to be difficult.
authors.affiliation: Dept. of Organ Regulatory Surgery, Fukushima Medical University School of Medicine.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sato
authors.forename: Shinji
authors.initials: S
authors.lastname: Ohki
authors.forename: Motoki
authors.initials: M
authors.lastname: Sassa
authors.forename: Kazunoshin
authors.initials: K
authors.lastname: Tachibana
authors.forename: Jin
authors.initials: J
authors.lastname: Ando
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Endo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Izumi
authors.initials: I
authors.lastname: Nakamura
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Koyama
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Seiichi
authors.initials: S
authors.lastname: Takenoshita
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004338:Drug Combinations; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D012003:Rectal Fistula / Q000473:pathology*; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid