title: Predictors and moderators of parent training efficacy in a sample of children with autism spectrum disorders and serious behavioral problems.
abstract: The Research Units on Pediatric Psychopharmacology--Autism Network reported additional benefit when adding parent training (PT) to antipsychotic medication in children with autism spectrum disorders and serious behavior problems. The intent-to-treat analyses were rerun with putative predictors and moderators. The Home Situations Questionnaire (HSQ) and the Hyperactivity/Noncompliance subscale of the Aberrant Behavior Checklist were used as outcome measures. Candidate predictors and moderators included 21 demographics and baseline measures of behavior. Higher baseline HSQ scores predicted greater improvement on the HSQ regardless of treatment assignment, but no other predictors of outcome were observed. None of the variables measured in this study moderated response to PT. Antipsychotic medication plus PT appears to be equally effective for children with a wide range of demographic and behavioral characteristics.
authors.affiliation: Ohio State University, McCampbell Hall, Rm 305, 1581 Dodd Drive, Columbus, OH 43210, USA.
authors.forename: Cristan
authors.initials: C
authors.lastname: Farmer
authors.forename: Luc
authors.initials: L
authors.lastname: Lecavalier
authors.forename: Sunkyung
authors.initials: S
authors.lastname: Yu
authors.forename: L
authors.initials: L
authors.lastname: Eugene Arnold
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: McDougle
authors.forename: Lawrence
authors.initials: L
authors.lastname: Scahill
authors.forename: Benjamin
authors.initials: B
authors.lastname: Handen
authors.forename: Cynthia R
authors.initials: CR
authors.lastname: Johnson
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Stigler
authors.forename: Karen
authors.initials: K
authors.lastname: Bearss
authors.forename: Naomi B
authors.initials: NB
authors.lastname: Swiezy
authors.forename: Michael G
authors.initials: MG
authors.lastname: Aman
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002648:Child; D002653:Child Behavior Disorders / Q000188:drug therapy / Q000523:psychology*; D002659:Child Development Disorders, Pervasive / Q000188:drug therapy / Q000523:psychology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010287:Parent-Child Relations; D010290:Parents / Q000193:education* / Q000523:psychology; D011237:Predictive Value of Tests; D018967:Risperidone / Q000627:therapeutic use; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone