title: Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formation.
abstract: Cancer metastasis consists of a sequential series of events, and the epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are recognized as critical events for metastasis of carcinomas. A current area of focus is the histopathological similarity between primary and metastatic tumors, and MET at sites of metastases has been postulated to be part of the process of metastatic tumor formation. Here, we summarize accumulating evidence from experimental studies that directly supports the role of MET in cancer metastasis, and we analyze the main mechanisms that regulate MET or reverse EMT in carcinomas. Given the critical role of MET in metastatic tumor formation, the potential to effectively target the MET process at sites of metastasis offers new hope for inhibiting metastatic tumor formation.
authors.affiliation: Department of Hepatobiliary and Splenic Surgery, Shengjing Hospital of China Medical University, Heping District, Shenyang 110004, Liaoning Province, China.
authors.forename: Dianbo
authors.initials: D
authors.lastname: Yao
authors.forename: Chaoliu
authors.initials: C
authors.lastname: Dai
authors.forename: Songlin
authors.initials: S
authors.lastname: Peng
mesh_terms: D002471:Cell Transformation, Neoplastic; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009362:Neoplasm Metastasis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D010641:Phenotype; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D059016:Tumor Microenvironment / Q000502:physiology
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors