title: Increased nuchal translucency, normal karyotype and infant development.
abstract: OBJECTIVE
  To investigate whether chromosomally normal fetuses with a nuchal translucency (NT) ≥ 99th percentile(3.5 mm) in the first trimester have an increased risk of delayed development at 2 years of age.
  
  
  METHODS
  The study included children of women from 10 Danish hospitals who had fetal NT either ≥ 99th percentile (Group 1) or <95th percentile (Group 2) in the first trimester. The groups were matched by gender,gestational age at birth and maternal age. There were twice as many children in Group 2 as in Group 1. Follow-up was conducted at 2 years of age, infant development being assessed by the 'Ages and Stages Questionnaire'. The cutoff value for delayed development was defined as the 5th percentile from the first 100 questionnaires from Group 2.
  
  
  RESULTS
  In a 1-year period 202 of 33 266 fetuses (0.6%)had NT ≥ 3.5 mm. Of these, 99 (49.0%) were liveborn with normal karyotype and normal ultrasound findings during pregnancy. The response rate to the ASQ was 83.3% in Group 1 and 71.4% in Group 2. A low ASQ score was found in 1.3% (1/80) and 4.4% (6/137)in Groups 1 and 2, respectively (P = 0.265), but no difference was found in the mean ASQ score between the two groups (P = 0.160).
  
  
  CONCLUSIONS
  Fetuses with NT ≥ 99th percentile, normal karyotype and normal ultrasound findings during pregnancy had no increased risk of developmental delay at 2 years of age compared with fetuses with normal NT(<95th percentile).
authors.affiliation: Department of Fetal Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. caroline winther@hotmail.com
authors.forename: C B
authors.initials: CB
authors.lastname: Miltoft
authors.forename: C K
authors.initials: CK
authors.lastname: Ekelund
authors.forename: B M
authors.initials: BM
authors.lastname: Hansen
authors.forename: A
authors.initials: A
authors.lastname: Lando
authors.forename: O B
authors.initials: OB
authors.lastname: Petersen
authors.forename: P
authors.initials: P
authors.lastname: Skovbo
authors.forename: F S
authors.initials: FS
authors.lastname: Jørgensen
authors.forename: L
authors.initials: L
authors.lastname: Sperling
authors.forename: H
authors.initials: H
authors.lastname: Zingenberg
authors.forename: A
authors.initials: A
authors.lastname: Nikkila
authors.forename: A C
authors.initials: AC
authors.lastname: Shalmi
authors.forename: I
authors.initials: I
authors.lastname: Stornes
authors.forename: V
authors.initials: V
authors.lastname: Ersbak
authors.forename: A
authors.initials: A
authors.lastname: Tabor
mesh_terms: D000328:Adult; D002657:Child Development; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D002658:Developmental Disabilities / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D048208:Nuchal Translucency Measurement / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011379:Prognosis; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors