title: Adult pancreatic neuroblastoma, an unusual site and fatal outcome.
abstract: In this report, we describe a classic case of stroma rich neuroblastoma, nodular type in a 22 year old female presented with a pancreatic mass. This rare and unusual presentation elicits several differential diagnostic categories including solid pseudopapillary tumor, pancreatic endocrine tumor, pancreatoblastoma and PNET. In this report, we tried to differentiate between them depending on the histopathological features and using panel of epithelial and neuroendocrine markers. Although of the rarity of pancreatic neuroblastoma as a primary site of origin, however it should be considered in the differential diagnosis of pancreatic masses in children and young adult. Neuropil and ganglionic differentiation are helpful features to recognize neuroblastoma and differentiate them from other small blue cell tumors. The fatal outcome of adult neuroblastoma confirming the independence of age as a prognostic factor in this neoplasm regardless of stage and histology.
authors.affiliation: Department of Pathology, Faculty of Medicine, Menofiya University, Shebein Elkom, Egypt. Asmaa_elsaidy@yahoo.com
authors.forename: Asmaa Gaber
authors.initials: AG
authors.lastname: Abdou
authors.forename: Nancy Youssef
authors.initials: NY
authors.lastname: Asaad
authors.forename: Ahmed
authors.initials: A
authors.lastname: Elkased
authors.forename: Hala
authors.initials: H
authors.lastname: Said
authors.forename: Marwa
authors.initials: M
authors.lastname: Dawoud
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009447:Neuroblastoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy