title: Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans.
abstract: BACKGROUND
  It has been known that hypertension is an independent risk factor for cardiovascular disease (CVD). CVD is the major cause of morbidity and mortality in developed and developing countries. Elevation of blood pressure (BP) increases the adverse effect for cardiovascular outcomes. Prevention of increased BP plays a crucial role in a reduction of those outcomes, leading to a decrease in mortality. Therefore, the purpose of this study was to investigate the effects of dietary black sesame meal on BP and oxidative stress in individuals with prehypertension.
  
  
  METHODS
  Twenty-two women and eight men (aged 49.8 ± 6.6 years) with prehypertension were randomly divided into two groups, 15 subjects per group. They ingested 2.52 g black sesame meal capsules or placebo capsules each day for 4 weeks. Blood samples were obtained after overnight fasting for measurement of plasma lipid, malondialdehyde (MDA) and vitamin E levels. Anthropometry, body composition and BP were measured before and after 4-week administration of black sesame meal or a placebo.
  
  
  RESULTS
  The results showed that 4-week administration of black sesame meal significantly decreased systolic BP (129.3 ± 6.8 vs. 121.0 ± 9.0 mmHg, P < 0.05) and MDA level (1.8 ± 0.6 vs. 1.2 ± 0.6 μmol/L, P < 0.05), and increased vitamin E level (29.4 ± 6.0 vs. 38.2 ± 7.8 μmol/L, P < 0.01). In the black sesame meal group, the change in SBP tended to be positively related to the change in MDA (R = 0.50, P = 0.05), while the change in DBP was negatively related to the change in vitamin E (R = -0.55, P < 0.05). There were no correlations between changes in BP and oxidative stress in the control group.
  
  
  CONCLUSIONS
  These results suggest the possible antihypertensive effects of black sesame meal on improving antioxidant status and decreasing oxidant stress. These data may imply a beneficial effect of black sesame meal on prevention of CVD.
authors.affiliation: Faculty of Physical Therapy, Mahidol University, Thailand.
authors.forename: Jatuporn
authors.initials: J
authors.lastname: Wichitsranoi
authors.forename: Natthida
authors.initials: N
authors.lastname: Weerapreeyakul
authors.forename: Patcharee
authors.initials: P
authors.lastname: Boonsiri
authors.forename: Chatri
authors.initials: C
authors.lastname: Settasatian
authors.forename: Nongnuch
authors.initials: N
authors.lastname: Settasatian
authors.forename: Nantarat
authors.initials: N
authors.lastname: Komanasin
authors.forename: Suchart
authors.initials: S
authors.lastname: Sirijaichingkul
authors.forename: Yaovalak
authors.initials: Y
authors.lastname: Teerajetgul
authors.forename: Nuchanart
authors.initials: N
authors.lastname: Rangkadilok
authors.forename: Naruemon
authors.initials: N
authors.lastname: Leelayuwat
mesh_terms: D000328:Adult; D000886:Anthropometry; D000959:Antihypertensive Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001823:Body Composition; D003906:Developing Countries; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology; D058246:Prehypertension / Q000188:drug therapy*; D012639:Seeds / Q000737:chemistry*; D031685:Sesamum / Q000737:chemistry*; D014810:Vitamin E / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D000975:Antioxidants; D008055:Lipids; D028321:Plant Preparations; D014810:Vitamin E; D008315:Malondialdehyde