title: [A case of Castleman disease with status epileptics originating from focal cortical dysplasia].
abstract: A 55-year-old man was admitted to our hospital because of prolonged consciousness disturbance after generalized convulsions. He had been afflicted with chronic inflammatory symptoms since 43 years of age, while multiple abdominal lymphadenopathy with a high level of serum IL-6 was revealed at the age of 53. FDG-PET/CT showed hypermetabolism in the left medial portion of the frontal lobe. Biopsy specimens of this lesion revealed a pathology of focal cortical dysplasia (FCD). Non-convulsive status epileptics continued despite enhanced treatment with antiepileptic drugs, while cortical T2 hyperintense lesions developed and expanded. Castleman disease was confirmed by pathological findings of abdominal lymph node biopsy specimens. The patient showed a higher level of IL-6 in cerebrospinal fluid (1,400 pg/dl) than in serum (720 pg/dl), thus indicating intrathecal production of this proinflammatory cytokine. We concluded that continuous exposure of FCD tissue to IL-6 may have augmented epileptogenesis of the originally silent congenital lesion.
authors.affiliation: Department of Neurology, Kanazawa Medical University.
authors.forename: Muichi
authors.initials: M
authors.lastname: Kaito
authors.forename: Haruka
authors.initials: H
authors.lastname: Iwao
authors.forename: Eriko
authors.initials: E
authors.lastname: Kinoshita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Funaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Tachibana
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsui
mesh_terms: D001927:Brain Diseases / Q000150:complications; D005871:Castleman Disease / Q000150:complications*; D004827:Epilepsy; D006801:Humans; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications; D065703:Malformations of Cortical Development, Group I; D008875:Middle Aged; D013226:Status Epilepticus / Q000209:etiology*