title: The effects of single and repeated exposure to 2.45 GHz radiofrequency fields on c-Fos protein expression in the paraventricular nucleus of rat hypothalamus.
abstract: This study investigated the effects of microwave radiation on the PVN of the hypothalamus, extracted from rat brains. Expression of c-Fos was used to study the pattern of cellular activation in rats exposed once or repeatedly (ten times in 2 weeks) to 2.45 GHz radiation in a GTEM cell. The power intensities used were 3 and 12 W and the Finite Difference Time Domain calculation was used to determine the specific absorption rate (SAR). High SAR triggered an increase of the c-Fos marker 90 min or 24 h after radiation, and low SAR resulted in c-Fos counts higher than in control rats after 24 h. Repeated irradiation at 3 W increased cellular activation of PVN by more than 100% compared to animals subjected to acute irradiation and to repeated non-radiated repeated session control animals. The results suggest that PVN is sensitive to 2.45 GHz microwave radiation at non-thermal SAR levels.
authors.affiliation: Departamento de Ciencias Morfológicas, Facultad de Medicina, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Jorge-Mora
authors.forename: M J
authors.initials: MJ
authors.lastname: Misa-Agustiño
authors.forename: J A
authors.initials: JA
authors.lastname: Rodríguez-González
authors.forename: F J
authors.initials: FJ
authors.lastname: Jorge-Barreiro
authors.forename: F J
authors.initials: FJ
authors.lastname: Ares-Pena
authors.forename: E
authors.initials: E
authors.lastname: López-Martín
mesh_terms: D000818:Animals; D005260:Female; D015870:Gene Expression / Q000528:radiation effects*; D008872:Microwaves; D010286:Paraventricular Hypothalamic Nucleus / Q000528:radiation effects*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000528:radiation effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016760:Proto-Oncogene Proteins c-fos