title: [Late relapse of breast cancer after adjuvant chemotherapy].
abstract: Late relapses (> 10 years) of breast cancer are mainly observed in ER positive tumors. The yearly relapse rate is still 0.5 % after 10 years. These relapses occurred even if adjuvant chemotherapy was given. Consequently, a better knowledge of the metastatic process is warranted in order to define better treatment options. We will discuss here a case of hormonosensitive breast cancer relapsing 20 years after the initial treatment. We will discuss the most recent data concerning late relapses. New hypotheses concerning disseminated tumoral cells and circulating cells will be reported. We will also review data about stem cells, tumor initiating cells and dormancy state.
authors.affiliation: Université de Liège, Belgique.
authors.forename: L
authors.initials: L
authors.lastname: Lousberg
authors.forename: J
authors.initials: J
authors.lastname: Somja
authors.forename: J
authors.initials: J
authors.lastname: Collignon
authors.forename: C
authors.initials: C
authors.lastname: Gilles
authors.forename: G
authors.initials: G
authors.lastname: Jerusalem
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*