title: Human buccal plate extraction socket regeneration with recombinant human platelet-derived growth factor BB or enamel matrix derivative.
abstract: The objective of this study was to assess the osseous healing of buccal plate extraction socket defects. There were four cohorts: group A (mineral collagen bone substitute [MCBS] scaffold alone), group B (MCBS with recombinant human platelet-derived growth factor BB [rhPDGF-BB; 0.3 mg/mL]), group C (MCBS with enamel matrix derivative [EMD]), and group D (combination of EMD with bone ceramic). The primary outcome of bone quality was evaluated using light microscopy, backscatter scanning electron microscopy, and histomorphometrics. Reentry surgery provided an opportunity for clinical observation of the healed ridge morphology. Sixteen patients with buccal wall extraction socket defects were randomized into four treatment groups of equal size. Grafting was provided at the time of extraction with advancement of the buccal flap for primary closure. A trephine core biopsy of the implant site preparation was performed after 5 months for implant placement. Histologic examination identified new bone healing around the biomaterial scaffolds. Statistically significant differences in new bone formation were not observed among the treatment groups. There was a histomorphometric trend toward more new bone for the rhPDGF-BB-treated group (group B). This group had the most favorable ridge morphology for optimal implant placement.
authors.affiliation: Department of Oral Medicine, Infection and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts, USA. marc_nevins@hms.harvard.edu
authors.forename: Marc L
authors.initials: ML
authors.lastname: Nevins
authors.forename: Marcelo
authors.initials: M
authors.lastname: Camelo
authors.forename: Peter
authors.initials: P
authors.lastname: Schupbach
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
authors.forename: Soo-Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: David M
authors.initials: DM
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000077214:Becaplermin; D001706:Biopsy; D015519:Bone Density / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000627:therapeutic use; D002516:Ceramics; D015331:Cohort Studies; D003094:Collagen / Q000627:therapeutic use; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous; D005500:Follow-Up Studies; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D010012:Osteogenesis / Q000187:drug effects; D011446:Prospective Studies; D020574:Proto-Oncogene Proteins c-sis / Q000627:therapeutic use*; D013524:Surgical Flaps; D054457:Tissue Scaffolds; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects; D055815:Young Adult
chemical_list: D043925:Angiogenesis Inducing Agents; D018786:Bone Substitutes; D003746:Dental Enamel Proteins; D020574:Proto-Oncogene Proteins c-sis; C109069:enamel matrix proteins; D000077214:Becaplermin; D003094:Collagen