title: [Treatment of multi-drug resistant tuberculosis].
abstract: Tuberculosis can be cured by 6 months chemotherapy, consisting of isoniazid (INH), rifampicin (RFP), pyrazinamide (PZA), and ethambutol (EB). However, the patients with tuberculosis caused by multi-drug resistant tuberculosis (MDR-TB) bacilli, defined as resistance to at least INH and RFP, poorly respond to this resimen. To work out the strategy for the elimination of MDR-TB, chemotherapy resume must be changed from standard resume to special one, that are made from effective and stronger at least three anti-tuberculosis drugs. The duration of treatment will be 18-24 months usually. If decreasing of tuberculosis bacilli in sputum is failed under new effective resume, surgical treatment may be indicated. Treatment results of MDR-TB are not satisfactory. But we need to not to make new MDR-TB cases.
authors.affiliation: Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association.
authors.forename: Masao
authors.initials: M
authors.lastname: Okumura
authors.forename: Shoji
authors.initials: S
authors.lastname: Kudoh
mesh_terms: D006801:Humans; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*