title: [Tamoxifen combined with coenzyme Q10 for idiopathic oligoasthenospermia].
abstract: OBJECTIVE
  To investigate the effects of tamoxifen (TMX) combined with coenzyme Q10 (CoQ10) on idiopathic oligoasthenospermia.
  
  
  METHODS
  A total of 183 patients with idiopathic oligoasthenospermia were randomly divided into a TMX + CoQ10 group (n = 63), a TMX group (n = 61) and a CoQ10 group (n = 59). At the end of 3 and 6 months of treatment, semen analyses and hormone tests were performed, and the results were compared with those obtained before the treatment.
  
  
  RESULTS
  Compared with the pre-treatment results, the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) and sperm concentration were significantly elevated in the TMX + CoQ10 and TMX groups (P < 0.05), but showed no significant difference in the CoQ10 group (P > 0.05); sperm motility and morphologically normal sperm were increased significantly in the TMX + CoQ10 and CoQ10 groups (P < 0.05), and slightly in the TMX group but with no statistically significant difference (P > 0.05).
  
  
  CONCLUSIONS
  Tamoxifen combined with CoQ10 can significantly improve sperm concentration, motility and morphology in patients with idiopathic oligoasthenospermia.
authors.affiliation: Department of Urology, The First Affiliated Hospital, Medical College, Xi'an, Shaanxi 710061, China. doc.tangkf@hotmail.com
authors.forename: Kai-Fa
authors.initials: KF
authors.lastname: Tang
authors.forename: Yao
authors.initials: Y
authors.lastname: Xing
authors.forename: Chun-Yun
authors.initials: CY
authors.lastname: Wu
authors.forename: Rui-Zhe
authors.initials: RZ
authors.lastname: Liu
authors.forename: Xin-Yang
authors.initials: XY
authors.lastname: Wang
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Xing
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000188:drug therapy*; D013629:Tamoxifen / Q000627:therapeutic use*; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D013629:Tamoxifen; D014451:Ubiquinone; C024989:coenzyme Q10