title: Interactions between subunits of the Mediator complex with gene-specific transcription factors.
abstract: The Mediator complex forms the bridge between gene-specific transcription factors and the RNA polymerase II (RNAP II) machinery. Mediator is a large polypetide complex consisting of about thirty polypeptides that are mostly conserved from yeast to human. Mediator coordinates RNAP II recruitment, phosphorylation of the C-terminal domain of RNAP II, enhancer-loop formation and post-initiation events. The focus of the review is to summarize the current knowledge of transcription factor/Mediator interactions in higher eukaryotes and illuminate the physiological and gene-selective roles of Mediator.
authors.affiliation: Max-Planck-Institute of Immunobiology and Epigenetics, Stübeweg 51, D-79108 Freiburg, Germany. borggrefe@ie-freiburg.mpg.de
authors.forename: Tilman
authors.initials: T
authors.lastname: Borggrefe
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Yue
mesh_terms: D000818:Animals; D006801:Humans; D050356:Lipid Metabolism; D020935:MAP Kinase Signaling System; D056892:Mediator Complex / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D056913:Mediator Complex Subunit 1 / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D019473:Transcription Factors, TFII / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: C538855:MED1 protein, human; C416944:MED15 protein, human; C492159:MED23 protein, human; C483045:MED25 protein, human; D056892:Mediator Complex; D056913:Mediator Complex Subunit 1; D014157:Transcription Factors; D019473:Transcription Factors, TFII; D012319:RNA Polymerase II