title: Therapeutic promise and challenges of targeting DLL4/NOTCH1.
abstract: DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development of γ-secretase inhibitors (GSIs) might offer insights into how to safely harness this important signaling pathway.
authors.affiliation: Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080, USA. minhong@gene.com.
authors.forename: Minhong
authors.initials: M
authors.lastname: Yan