title: Clinical and microbiological efficacy of an antimicrobial mouth rinse containing 0.05% cetylpyridinium chloride in patients with gingivitis.
abstract: OBJECTIVE
  the aim of this study was to evaluate the effects of the use of a mouth rinse and dentifrice with cetylpyridinium chloride (CPC) in patients with gingivitis.
  
  
  METHODS
  the study was designed as a 1-month, double-blind, parallel, randomized clinical trial comparing a negative control regimen (minus active ingredients dentifrice and mouth rinse) with the test products (dentifrice and mouth rinse with 0.05% CPC) in terms of plaque and gingival indexes (PI, GI), patient-based and microbiological outcome variables. The comparisons in relation to the main outcome variables (PI and GI) were made by means of the t-test, either unpaired or paired for the intergroup and intragroup comparisons, respectively.
  
  
  RESULTS
  no differences were detected at baseline. Both groups showed statistically significant decreases in GI (0.17-0.19), without intergroup differences. The PI demonstrated a significant decrease of -0.12 in the test group and minor changes in the negative control group (increase of +0.01). Differences between groups showed a tendency towards statistical significance. A limited impact was observed for microbiological variables in both groups.
  
  
  CONCLUSIONS
  the results of this study show limited benefits of the evaluated formulations as adjuncts to unsupervised oral hygiene in reducing plaque accumulation, and no effect on gingivitis.
authors.affiliation: Graduate Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Rioboo
authors.forename: V
authors.initials: V
authors.lastname: García
authors.forename: J
authors.initials: J
authors.lastname: Serrano
authors.forename: A
authors.initials: A
authors.lastname: O'Connor
authors.forename: D
authors.initials: D
authors.lastname: Herrera
authors.forename: M
authors.initials: M
authors.lastname: Sanz
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D002594:Cetylpyridinium / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D003131:Combined Modality Therapy; D003773:Dental Plaque / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D003774:Dental Plaque Index; D003802:Dentifrices; D004311:Double-Blind Method; D005260:Female; D005891:Gingivitis / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D009067:Mouthwashes; D010512:Periodontal Index; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D003802:Dentifrices; D009067:Mouthwashes; D002594:Cetylpyridinium