title: Cell migration: PKA and RhoA set the pace.
abstract: A new study shows that protein kinase A (PKA) activity establishes a signaling loop that governs protrusion-retraction cycles in migrating cells. PKA activity near the leading edge of protrusions phosphorylates RhoA and inhibits its activity via increased association with RhoGDI.
authors.affiliation: Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
authors.forename: Karen A
authors.initials: KA
authors.lastname: Newell-Litwa
authors.forename: Alan Rick
authors.initials: AR
authors.lastname: Horwitz
mesh_terms: D000818:Animals; D002465:Cell Movement; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D010766:Phosphorylation; D020742:rhoA GTP-Binding Protein / Q000378:metabolism*
chemical_list: D017868:Cyclic AMP-Dependent Protein Kinases; D020742:rhoA GTP-Binding Protein