title: A fluoro analogue of UDP-α-D-glucuronic acid is an inhibitor of UDP-α-D-apiose/UDP-α-D-xylose synthase.
abstract: UDP-2F-glucuronic acid was synthesized and analyzed as a mechanistic probe to investigate the ring contraction step catalyzed by UDP-d-apiose/UDP-d-xylose synthase (AXS).
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Sei-hyun
authors.initials: SH
authors.lastname: Choi
authors.forename: Mark W
authors.initials: MW
authors.lastname: Ruszczycky
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Hung-wen
authors.initials: HW
authors.lastname: Liu
mesh_terms: D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D005461:Fluorine / Q000737:chemistry*; D014535:Uridine Diphosphate Glucuronic Acid / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000737:chemistry*; D014539:Uridine Diphosphate Sugars / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; C511616:UDP-apiose; D014539:Uridine Diphosphate Sugars; C081993:UDP-2-fluoro-2-deoxyglucuronic acid; D014535:Uridine Diphosphate Glucuronic Acid; D005461:Fluorine; D002262:Carboxy-Lyases; C023257:UDPglucuronate decarboxylase