title: Refractory cutaneous Rosai-Dorfman disease responsive to cryotherapy.
abstract: Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare, acquired, idiopathic, nonneoplastic histiocytosis. In many cases the skin is involved and treatment is indicated. Various treatment options have been attempted with variable success. We report a case of cutaneous Rosai-Dorfman disease (CRDD) refractory to both topical and intralesional corticosteroid therapy that showed a rapid and remarkable response to cryotherapy. These observations suggest that cryotherapy should be considered as a therapeutic option for CRDD.
authors.affiliation: University of British Columbia Faculty of Medicine, Vancouver, Canada.
authors.forename: Raina
authors.initials: R
authors.lastname: Fumerton
authors.forename: Nigel
authors.initials: N
authors.lastname: Ball
authors.forename: Youwen
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D017679:Cryotherapy; D003937:Diagnosis, Differential; D005260:Female; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008875:Middle Aged