title: A case of hepatitis C-associated osteosclerosis with xanthogranulomatous cholecystitis.
abstract: A 62-year-old woman presented with a markedly increased serum ALP level of skeletal origin during a regular follow-up of chronic hepatitis C. Serum calcium, phosphorus, and intact-PTH levels were normal and bone turnover markers were increased. Her generalized bone density was diffusely increased. These findings were consistent with hepatitis C-associated osteosclerosis (HCAO). She underwent cholecystectomy, as gallbladder cancer was suspected; however, histopathological findings demonstrated xanthogranulomatous cholecystitis. After cholecystectomy, serum ALP level and bone turnover markers were gradually decreased. This may indicate the existence of a novel osteogenic factor in the gallbladder in HCAO.
authors.affiliation: Department of Endocrinology, Kyoto City Hospital, Japan. yujih@kuhp.kyoto-u.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hataya
authors.forename: Yasato
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Hideki
authors.initials: H
authors.lastname: Chusho
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kirishima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shintani
authors.forename: Taisuke
authors.initials: T
authors.lastname: Morimoto
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D002764:Cholecystitis / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology; D005260:Female; D006099:Granuloma / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology; D019698:Hepatitis C, Chronic / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology; D006801:Humans; D008875:Middle Aged; D010026:Osteosclerosis / Q000150:complications* / Q000175:diagnosis / Q000201:enzymology; D014973:Xanthomatosis / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology
chemical_list: D000469:Alkaline Phosphatase