title: A randomized comparison study of Aquacel Ag and Glucan II as donor site dressings with regard to healing time, cosmesis, infection rate, and patient's perceived pain: a pilot study.
abstract: This study was undertaken to compare pain, healing time, infection rate, and cosmetic outcome between Aquacel Ag (Convatec) and Glucan II (Brennan Medical) as donor site dressings. The authors performed a prospective, randomized, patient-controlled study. Eligible patients had two donor sites harvested. One site was dressed with Aquacel Ag and the other site with Glucan II. Patients were followed at set time points for 6 months to determine the rate of epithelialization, patient's perceived pain, infection rate, and the cosmetic outcome. A total of 20 patients were enrolled in the study. All patient data were collected through reepithelialization. The average time to wound healing for Aquacel Ag was 12.5 ± 2.07 days compared with Glucan II 12.7 ± 1.99 days. Perceived pain scores for each donor site were recorded. On postoperative day 5, patients reported significantly less pain with the Aquacel Ag site (Aquacel Ag 1.75 vs Glucan II 2.5, P = .02). Three donor sites showed clinical signs of infection (two Glucan II and one Aquacel Ag) prompting culture and dressing removal. There was no statistically significant difference in cosmetic outcomes of the donor sites at any time point. When comparing Aquacel Ag and Glucan II, our study has determined that there is no significant difference with regard to healing time, infection rates, and cosmetic outcomes. Both dressings are comparable with regard to ease of application and postoperative care.
authors.affiliation: Department of Rehabilitation Services and Regional Burn Center at the University of California, Irvine, Medical Center, Orange, California 92868, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Bailey
authors.forename: Melissa
authors.initials: M
authors.lastname: Carmean
authors.forename: Marianne
authors.initials: M
authors.lastname: Cinat
authors.forename: Kimberly
authors.initials: K
authors.lastname: Burton
authors.forename: Christopher
authors.initials: C
authors.lastname: Lane
authors.forename: Darren
authors.initials: D
authors.lastname: Malinoski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D002056:Burns / Q000150:complications / Q000188:drug therapy*; D002266:Carboxymethylcellulose Sodium / Q000191:economics / Q000627:therapeutic use*; D016001:Confidence Intervals; D003358:Cosmetics; D005260:Female; D005936:Glucans / Q000191:economics / Q000627:therapeutic use*; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings / Q000191:economics; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D010465:Perception; D010865:Pilot Projects; D016038:Skin Transplantation / Q000379:methods*; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
chemical_list: D003358:Cosmetics; D005936:Glucans; D002266:Carboxymethylcellulose Sodium