title: Platelet-mediated thrombolysis in patients with δ-storage pool deficiency:  a thrombelastographic analysis.
abstract: We present the first thrombelastographic descriptions of three patients with δ-storage pool deficiency, a platelet disorder that involves a deficiency of dense granules and moderate bleeding. The patients demonstrated a 49-54% loss of platelet-mediated clot strength over a 1-2-h period after normal thrombus formation. This pattern persisted, with some attenuation of loss of strength following administration of epsilon aminocaproic acid, desmopressin and platelets for tonsillectomy. Assessment of platelet function in patients with platelet granule disorders can be accomplished with thrombelastographic methods in ambulatory and perioperative settings; however, the effects of therapy for this disorder cannot be monitored with thrombelastography without obtaining a blood sample prior to prophylactic hemostatic intervention.
authors.affiliation: Department of Anesthesiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Brodsky
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Machovec
authors.forename: Bryan P
authors.initials: BP
authors.lastname: Chambers
authors.forename: Vance G
authors.initials: VG
authors.lastname: Nielsen
mesh_terms: D000293:Adolescent; D015119:Aminocaproic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D003594:Cytoplasmic Granules; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006490:Hemostatics / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D010981:Platelet Storage Pool Deficiency / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D017713:Platelet Transfusion; D013916:Thrombelastography / Q000379:methods*; D014068:Tonsillectomy
chemical_list: D006490:Hemostatics; D003894:Deamino Arginine Vasopressin; D015119:Aminocaproic Acid