title: A patient with prostate cancer and multiple myeloma-diagnostics and possible association of both diseases.
abstract: In this report, we describe a case of a patient with prostate cancer and multiple myeloma as the second metachronous malignant disease. To our knowledge, synchronous occurrence of bone marrow prostate cancer metastases and multiple myeloma-as it was found in the clinical disease course of our patient-has not been documented in the literature. Among other diagnostic procedures, cytomorphology and immunocytochemistry analyses contribute to detection of metastases of epithelial cells and synchronous plasma cell proliferation in bone marrow. Occurrence of multiple myeloma and prostate cancer in our patient adds to other similar reports and points to possible association between both diseases and also to other factors involved in the development of a second malignant disease. Further studies are needed to confirm and clarify this association, because prostate cancer is a relatively common malignant disease.
authors.affiliation: Department of Pathology and Cytology, Clinical Hospital, Sveti Duh, and Department of Medical Biochemistry and Hematology, Zagreb University Faculty of Pharmacy and Biochemistry, 10000 Zagreb, Croatia. mirna.sucic@yahoo.com
authors.forename: Mirna
authors.initials: M
authors.lastname: Sučić
authors.forename: Vesna
authors.initials: V
authors.lastname: Bišof
authors.forename: Mirjana
authors.initials: M
authors.lastname: Cačić
authors.forename: Sanda Bašić
authors.initials: SB
authors.lastname: Kinda
authors.forename: Danijela
authors.initials: D
authors.lastname: Kolenc
authors.forename: Nives
authors.initials: N
authors.lastname: Ljubić
authors.forename: Tena
authors.initials: T
authors.lastname: Sučić
authors.forename: Kristina
authors.initials: K
authors.lastname: Potočki
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary; D014408:Biomarkers, Tumor / Q000378:metabolism; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000556:secondary; D049109:Cell Proliferation; D018450:Disease Progression; D004847:Epithelial Cells / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor