title: [Comparative study on pharmacokinetics of curcumin extract of rhizoma curcumae longae and rhizoma wenyujin concisum in rats].
abstract: OBJECTIVE
  To compare the pharmacokinetics of curcumin extracted from Rhizoma Curcumae Longe and Rhizoma Wenyujin Concisum in rats.
  
  
  METHODS
  Sprague Dawley rats were administrated extracts of Rhizoma Curcumae Longae and Rhizoma Wenyujin Concisum. The pharmacokinetic parameters were calculated with 3P97 program.
  
  
  RESULTS
  The plasma concentration-time curves of curcumin that extracted from Rhizoma Curcumae Longae and Rhizoma Wenyujin Concisum were fitted with one-compartment model respectively. The AUC and Cmax of curcumin extracted from Rhizoma Curcumae Longae were much greater than of extracted from Rhizoma Wenyujin Concisum.
  
  
  CONCLUSIONS
  There were significantly difference in pharmacokinetic parameters of curcumin in Rhizoma Curcumae Longae and Rhizoma Wenyujin Concisum in rats.
authors.affiliation: Fengrun district People Hospital, Tang shan 064000, China.
authors.forename: Guo-xian
authors.initials: GX
authors.lastname: Yao
authors.forename: Gang
authors.initials: G
authors.lastname: Han
authors.forename: Wan-ying
authors.initials: WY
authors.lastname: La
authors.forename: Rui
authors.initials: R
authors.lastname: Bi
authors.forename: Cheng-qiang
authors.initials: CQ
authors.lastname: Wang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D030024:Curcuma / Q000737:chemistry* / Q000145:classification; D003474:Curcumin / Q000493:pharmacokinetics*; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D027343:Rhizome / Q000737:chemistry; D013997:Time Factors
chemical_list: D010936:Plant Extracts; D003474:Curcumin