title: [Risk-reducing surgery in women at hereditary risk of gynaecological cancer].
abstract: OBJECTIVE
  To present up-to-date knowledge concerning risk-reducing surgery in carriers of susceptibility mutations among hereditary breast/ovarian cancer syndrome and Lynch syndrome.
  
  
  METHODS
  Review.
  
  
  METHODS
  Oncogynecological Center, Department of Obstetrics and Gynecology, Charles University in Prague - First Faculty of Medicine and General Faculty Hospital, Prague.
  
  
  METHODS
  After having reviewed the now-a-days literature and summarized our experience we present here an overview of risk-reducing strategies in gynecology and a proposal of guidelines to risk-reducing salpingo-oophorectomy and hysterectomy.
  
  
  CONCLUSIONS
  Risk-reducing salpingo-oophorectomy or hysterectomy is the most effective strategy for gynecological cancer prevention in susceptibility gene mutation carriers so far. This type of surgery, however, requires specific indication work-up and techniques different from those standardly used.
authors.affiliation: Onkogynekologické centrum, Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha. michal.zikan@lf1.cuni.cz
authors.forename: M
authors.initials: M
authors.lastname: Zikán
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D005833:Genital Neoplasms, Female / Q000235:genetics* / Q000517:prevention & control; D006801:Humans; D007044:Hysterectomy; D010051:Ovarian Neoplasms / Q000235:genetics; D010052:Ovariectomy; D040242:Risk Reduction Behavior; D058994:Salpingectomy