title: Initial excited-state structural dynamics of 2'-deoxyguanosine determined via UV resonance Raman spectroscopy.
abstract: The resonance Raman spectra of 2'-deoxyguanosine, a DNA nucleoside, were measured in aqueous solution at wavelengths throughout its 260 nm absorption band. Self-consistent analysis of the resulting resonance Raman excitation profiles and absorption spectrum using a time-dependent wave packet formalism with two electronic states yielded the initial excited-state structural dynamics in both states. The vibrational modes containing the N(7)═C(8) stretching and C(8)-H bending internal coordinates were found to exhibit significant initial structural dynamics upon photoexcitation to either state and are coincident with the photochemical reaction coordinate involving the formation of the 2'-deoxyguanosine cation radical.
authors.affiliation: Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
authors.forename: Amira F
authors.initials: AF
authors.lastname: El-Yazbi
authors.forename: Alexandra
authors.initials: A
authors.lastname: Palech
authors.forename: Glen R
authors.initials: GR
authors.lastname: Loppnow
mesh_terms: D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D011789:Quantum Theory; D013059:Spectrum Analysis, Raman; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D003849:Deoxyguanosine