title: [Sperm DNA damage and unexplained recurrent spontaneous abortion].
abstract: OBJECTIVE
  To explore the relationship of sperm DNA damage with unexplained recurrent spontaneous abortion (URSA).
  
  
  METHODS
  Sperm DNA fragmentation was evaluated by sperm chromatin dispersion (SCD), and the results were expressed in terms of DNA fragmentation index (DFI). DFIs were measured in the male partners of 56 women with URSA (the experiment group) and of 31 without URSA (the control group).
  
  
  RESULTS
  The DFI was shown to be (11.0% - 56.9%) in the experiment group, 21 (37.5%) of the subjects over 30%, as compared with (10.0% -36.8%) in the control group, only 8 (25.8%) of the subjects over 30%, significantly higher in the former than in the latter (29.4% vs 25.5%, P < 0.05).
  
  
  CONCLUSIONS
  There is a relationship between sperm DNA damage and URSA.
authors.affiliation: Reproductive Center, Navy General Hospital, Beijing 100048, China.
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Liu
authors.forename: Ai-Ming
authors.initials: AM
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Shang
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Wei-Zhou
authors.initials: WZ
authors.lastname: Wang
authors.forename: Yu-Liang
authors.initials: YL
authors.lastname: Shen
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology*; D000328:Adult; D016022:Case-Control Studies; D004249:DNA Damage; D053938:DNA Fragmentation; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D013094:Spermatozoa / Q000473:pathology*