title: The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death.
abstract: Currently, no drugs are available to protect humans from γ-irradiation-induced death. Because reactive oxygen species are produced upon exposure to γ-irradiation and directly responsible for the resulting death, we hypothesized that antioxidants found in foodstuffs may provide a safe and potent means of antioxidant-dependent radioprotection. Here, we describe our studies investigating the radioprotective properties of resveratrol and 3,5,4'-tri-O-acetylresveratrol. Each of these natural antioxidants was found to protect live cells after γ-irradiation. In mice, the use of 3,5,4'-tri-O-acetylresveratrol with Cremophor EL was particularly effective, indicating that this natural antioxidant may be a leading candidate for radioprotective drug development.
authors.affiliation: Center for Medical Countermeasures Against Radiation, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Koide
authors.forename: Sami
authors.initials: S
authors.lastname: Osman
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Garner
authors.forename: Fengling
authors.initials: F
authors.lastname: Song
authors.forename: Tracy
authors.initials: T
authors.lastname: Dixon
authors.forename: Joel S
authors.initials: JS
authors.lastname: Greenberger
authors.forename: Michael W
authors.initials: MW
authors.lastname: Epperly