title: Lack of association of the polymorphism of the CCR5 gene in liver recipients with acute rejection from China.
abstract: OBJECTIVE
  This study sought to investigate the associations between polymorphisms in the chemokine receptor 5 gene and acute rejection in liver transplant.
  
  
  METHODS
  A total of 266 patients who underwent a liver transplant between January 2006 and March 2009 were enrolled in this study. Genomic DNA was extracted from whole blood, and chemokine receptor 5Δ32 was detected by polymerase chain reaction. Eight nucleotide polymorphism loci in the chemokine receptor 5 gene were detected by Applied Biosystems SNaPShot and TaqMan technologies.
  
  
  RESULTS
  Chemokine receptor 5Δ32 mutation was not detected in all the individuals from China. There was no significant association between the single nucleotide polymorphism in chemokine receptor 5 gene and acute rejection.
  
  
  CONCLUSIONS
  Single nucleotide polymorphisms in a single gene of the chemokine receptor 5 might not play a role in acute rejection after liver transplant.
authors.affiliation: Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health; First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Hai-yang
authors.initials: HY
authors.lastname: Xie
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Shu-Sen
authors.initials: SS
authors.lastname: Zheng
mesh_terms: D000208:Acute Disease; D000328:Adult; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006801:Humans; D015810:Linkage Disequilibrium; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D019713:Receptors, CCR5 / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D019713:Receptors, CCR5