title: Quinonoid and phenazine compounds: synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis.
abstract: Several quinonoid and phenazine compounds were synthesized in moderate to high yields and showed activity against H(37)Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis. The cytotoxity of the compounds were evaluated against human peripheral blood mononuclear cells (PBMC) and these substances emerge as promising antitubercular prototypes.
authors.affiliation: Núcleo de Pesquisas de Produtos Naturais, UFRJ, 21941-971 Rio de Janeiro, Brazil.
authors.forename: Paula F
authors.initials: PF
authors.lastname: Carneiro
authors.forename: Maria do Carmo F R
authors.initials: Mdo C
authors.lastname: Pinto
authors.forename: Tatiane S
authors.initials: TS
authors.lastname: Coelho
authors.forename: Bruno C
authors.initials: BC
authors.lastname: Cavalcanti
authors.forename: Cláudia
authors.initials: C
authors.lastname: Pessoa
authors.forename: Carlos A
authors.initials: CA
authors.lastname: de Simone
authors.forename: Isabelle K C
authors.initials: IK
authors.lastname: Nunes
authors.forename: Nathalia M
authors.initials: NM
authors.lastname: de Oliveira
authors.forename: Renata G
authors.initials: RG
authors.lastname: de Almeida
authors.forename: Antonio V
authors.initials: AV
authors.lastname: Pinto
authors.forename: Kelly C G
authors.initials: KC
authors.lastname: de Moura
authors.forename: Pedro A
authors.initials: PA
authors.lastname: da Silva
authors.forename: Eufrânio N
authors.initials: EN
authors.lastname: da Silva Júnior
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D004352:Drug Resistance, Microbial; D007538:Isoniazid / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010619:Phenazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D000995:Antitubercular Agents; D010619:Phenazines; D011809:Quinones; D007538:Isoniazid; D012293:Rifampin