title: Spectroscopic, thermal and antitumor investigations of sulfasalazine drug in situ complexation with alkaline earth metal ions.
abstract: The complexes of sulfasalazine (H(3)Suz) with some of alkaline metals Mg(II), Ca(II), Sr(II) and Ba(II) have been investigated. Sulfasalazine complexes were synthesized and characterized by spectroscopic tools; infrared spectra, electronic and mass spectra. The IR spectra of the prepared complexes were suggested that the H(3)Suz behaves as a bi-dentate ligand through the carboxylic and phenolic groups. The molar conductance measurements gave an idea about the non-electrolytic behavior of the H(3)Suz complexes. The thermal decomposition processes for metal(II) complexes of H(3)Suz viz: [M(HSuz)(H(2)O)(4)] (where M = Mg(II), Ca(II), Sr(II) or Ba(II)) have been accomplished on the basis of TG/DTG and DTA studies, and the formula conforms to the stoichiometry of the complexes based on elemental analysis. The kinetic analyses of the thermal decomposition were studied using the Coats-Redfern and Horowitz-Metzger equations. The antitumor and antimicrobial activities of the H(3)Suz and their alkaline metal(II) complexes were evaluated.
authors.affiliation: Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt. msrefat@yahoo.com
authors.forename: Moamen S
authors.initials: MS
authors.lastname: Refat
authors.forename: Soha F
authors.initials: SF
authors.lastname: Mohamed
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005982:Glutathione Transferase / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D013058:Mass Spectrometry / Q000379:methods; D008670:Metals / Q000737:chemistry*; D008956:Models, Chemical; D013055:Spectrophotometry, Infrared / Q000379:methods; D013057:Spectrum Analysis / Q000379:methods*; D012460:Sulfasalazine / Q000494:pharmacology*; D013696:Temperature; D013818:Thermogravimetry / Q000379:methods
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D008670:Metals; D012460:Sulfasalazine; D005982:Glutathione Transferase