title: Cost-effectiveness analysis of memantine for moderate-to-severe Alzheimer's disease in the Netherlands.
abstract: OBJECTIVE
  The purpose of this study was to estimate the cost-effectiveness of memantine relative to standard care in patients with moderate-to-severe Alzheimer's disease in the Netherlands.
  
  
  METHODS
  A country-adapted five-year Markov model simulated disease progression through a series of states, defined by dependency and disease severity. Transition probabilities were derived from trials, with utility and epidemiological data obtained from a longitudinal Dutch cohort. Cost-effectiveness was described in terms of quality-adjusted life years and time spent in a nondependent state or in a moderate severity state.
  
  
  RESULTS
  Memantine monotherapy versus standard care led to 0.058 quality-adjusted life years gained (1.207 versus 1.265), longer time in a nondependent state (from 1.602 to 1.751 years) and in a moderate state (from 2.051 to 2.141 years), and no additional costs (€113,927 versus €110,097). Robustness of results was confirmed through sensitivity analyses.
  
  
  CONCLUSIONS
  Memantine is dominant compared with standard care in the Netherlands. Results are consistent with similar economic evaluations in other countries.
authors.affiliation: Field Product Management, Lundbeck BV, Amsterdam, The Netherlands;
authors.forename: Bart
authors.initials: B
authors.lastname: Hoogveldt
authors.forename: Benoît
authors.initials: B
authors.lastname: Rive
authors.forename: Johan
authors.initials: J
authors.lastname: Severens
authors.forename: Khaled
authors.initials: K
authors.lastname: Maman
authors.forename: Chantal
authors.initials: C
authors.lastname: Guilhaume