title: [Association of thrombospondin-1 gene N700S polymorphism with coronary artery disease].
abstract: To investigate the association of thrombospondin-1 (TSP- 1) gene A8831G (N700S) polymorphism with coronary artery disease (CAD).
  
  
  
  This study was conducted with a case-control design including 178 patients with CAD (55 AMI) and 158 healthy subjects. The TSP-1 N700S polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism analysis.
  
  
  
  No significant difference of the AG genotype in CAD group and control group (1.7% compared with 0.6%, P=0.375) was detected. None of the homozygotes was detected for the G allele. The prevalence of the G allele was not significantly different between CAD group and controls (0.8% compared with 0.3%, P=0.376). No significant difference of the AG genotype in AMI group and control group (3.6% compared with 0.6%, P=0.104). The prevalence of G allele was not significantly different between AMI patients and controls (1.8% compared with 0.3%, P=0.364).
  
  
  
  There are TSP-1 N700S polymorphisms in Chinese Zhejiang Han people, but the TSP-1 N700S variant shows a much lower prevalence compared with Western populations and may be not a potential risk for CAD and AMI.
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. shiyuping007@hotmail.com
authors.forename: Yu-ping
authors.initials: YP
authors.lastname: Shi
authors.forename: Hua-lan
authors.initials: HL
authors.lastname: Gong
authors.forename: Hai-bo
authors.initials: HB
authors.lastname: Liu
authors.forename: Jiang
authors.initials: J
authors.lastname: Shan
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
authors.forename: Jian-an
authors.initials: JA
authors.lastname: Wang
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D019700:Thrombospondin 1 / Q000235:genetics*
chemical_list: D019700:Thrombospondin 1