title: Negative transcriptional regulation of the human periostin gene by YingYang-1 transcription factor.
abstract: Periostin (POSTN), an osteoblast-specific secreted protein known to be associated with cell adhesion activity for bone formation and development by the epithelial cell-derived tumors, leads to a significant enhancement in angiogenesis and tumorigenesis. At present, little is known about the mechanisms underlying its transcriptional control either in physiological or neoplastic conditions. In this study we demonstrate that the ability of the human POSTN promoter to drive transcription mostly depends on the activity of YingYang-1 (YY1) zinc finger transcription factor. YY1, whose regulatory role in biology includes, besides transcriptional control, also chromatin remodeling, DNA damage repair and tumorigenesis, acts as a strong negative modulator of the POSTN expression. We retain that the identification of the functional role of YY1 in the transcriptional control of the human POSTN gene adds new insights in the studies focused on gene expression in normal and transformed cells.
authors.affiliation: Department of Experimental and Clinical Medicine, "Magna Græcia" University of Catanzaro, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Romeo
authors.forename: L
authors.initials: L
authors.lastname: Falbo
authors.forename: M
authors.initials: M
authors.lastname: Di Sanzo
authors.forename: R
authors.initials: R
authors.lastname: Misaggi
authors.forename: M C
authors.initials: MC
authors.lastname: Faniello
authors.forename: T
authors.initials: T
authors.lastname: Barni
authors.forename: G
authors.initials: G
authors.lastname: Cuda
authors.forename: G
authors.initials: G
authors.lastname: Viglietto
authors.forename: C
authors.initials: C
authors.lastname: Santoro
authors.forename: B
authors.initials: B
authors.lastname: Quaresima
authors.forename: F
authors.initials: F
authors.lastname: Costanzo
mesh_terms: D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism; D002478:Cells, Cultured; D015536:Down-Regulation / Q000235:genetics; D020868:Gene Silencing / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D011485:Protein Binding / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics; D014162:Transfection; D050986:YY1 Transcription Factor / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D015815:Cell Adhesion Molecules; C512835:POSTN protein, human; D050986:YY1 Transcription Factor; C494698:YY1 protein, human