title: [Effects of bushen huoxue recipe on urinary levels of albumin, IL-6, TGF-beta1 and MCP-1 in chronic nephritis patients of shen-deficiency blood-stasis syndrome].
abstract: OBJECTIVE
  To observe the effect of Bushen Huoxue Recipe (BSHXR, a Chinese medicine recipe for Shen reinforcing and blood circulation activating) on the levels of urinary albumin, interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-beta1), and monocyte chemotactic protein-1 (MCP-1) in chronic nephritis patients of Shen-deficiency blood-stasis syndrome.
  
  
  METHODS
  Forty-five patients were blocking assigned randomly to two groups, fifteen patients in the control group and thirty in the treatment group. All orally took Monopril 10 mg, once daily. But BSHXR was given additionally to patients in the treatment group after decocting,one dose per day (taken in two times). The treatment course for both groups was eight weeks. Besides, a normal control group consisting of six healthy subjects from health examination of Shuguang Hospital was set up. The 24-h urinary albumin and contents of TGF-beta1, IL-6 and MCP-1 in urine of all subjects were observed.
  
  
  RESULTS
  Compared with before treatment the 24-h urinary albumin was obviously reduced in the treatment group, showing significant difference (P<0.01). The urinary 24-h albumin decreased in the control group, with statistical significance (P<0.05). Statistical difference existed between the treatment group and the control group after treatment (P<0.01). Compared with before treatment, urinary levels of IL-6, TGF-beta1, and MCP-1 were all down-regulated in the treatment group and the control group after treatment (P<0.01), and the decreasing of IL-6 and TGF-beta1, levels was more significant in the treatment group statistically (P<0.05).
  
  
  CONCLUSIONS
  BSHXR could attenuate the albuminuria in patients of chronic nephritis. Its mechanism might be possibly correlated with its down-regulation of IL-6, TGF-beta1, and MCP-1 levels.
authors.affiliation: Huashan Hospital of Fudan University, Shanghai 200040.
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Duan
authors.forename: Jing-cheng
authors.initials: JC
authors.lastname: Dong
authors.forename: Li-qun
authors.initials: LQ
authors.lastname: He
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000188:drug therapy / Q000652:urine; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000652:urine*; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000652:urine; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009393:Nephritis / Q000188:drug therapy* / Q000652:urine; D008517:Phytotherapy; D053773:Transforming Growth Factor beta1 / Q000652:urine*
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D004365:Drugs, Chinese Herbal; C508600:IL6 protein, human; D015850:Interleukin-6; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; C527851:bushen huoxue