title: Development of segmented polyurethane elastomers with low iodine content exhibiting radiopacity and blood compatibility.
abstract: Biofunctionally active and inherently radiopaque polymers are the emerging need for biomedical applications. Novel segmented polyurethane elastomer with inherent radiopacity was prepared using aliphatic chain extender 2,3-diiodo-2-butene-1,4-diol, polyol polytetramethylene glycol and 4,4'-methylenebis(phenyl isocyanate) (MDI) for blood compatible applications. Aliphatic polyurethane was also prepared using hexamethylene diisocyanate for comparison. X-ray analysis of the polyurethanes revealed good radiopacity even at a relatively low concentration of 3% iodine in aromatic polyurethane and 10% in aliphatic polyurethane. The polyurethanes also possessed excellent thermal stability. MDI-based polyurethane showed considerably higher tensile strength than the analogous HDI-based polyurethane. MDI-based aromatic polyurethane exhibited a dynamic surface morphology in aqueous medium, resulting in the segregation of hydrophilic domains which was more conducive to anti-thrombogenic properties. The polyurethane was cytocompatible with L929 fibroblast cells, non-hemolytic, and possessed good blood compatibility.
authors.affiliation: Polymer Science Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
authors.forename: S
authors.initials: S
authors.lastname: Dawlee
authors.forename: Muthu
authors.initials: M
authors.lastname: Jayabalan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D001769:Blood; D002460:Cell Line; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D020724:Elastomers / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D066298:In Vitro Techniques; D007455:Iodine / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D051379:Mice; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D020724:Elastomers; D011140:Polyurethanes; D007455:Iodine