title: Recreational physical activity and risk of head and neck cancer: a pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium.
abstract: Increasing evidence suggests that physical activity could prevent cancer, but scanty data is available on head and neck cancer (HNC). The aim of our study is to clarify the effect of recreational physical activity (rPA) on HNC. We analyzed data from four case-control studies, including 2,289 HNC cases and 5,580 controls. rPA was classified as: none/low (reference group), moderate and high. We calculated summary Odds Ratios (ORs) by pooling study-specific ORs. Overall, moderate rPA was associated with 22% lower risk of HNC compared to those with none or very low rPA levels [OR = 0.78, 95% Confidence Interval (95% CI): 0.66, 0.91]. Moderate rPA is associated with reduced risk of oral (OR = 0.74, 95% CI: 0.56, 0.97) and pharyngeal cancer (OR = 0.67, 95% CI: 0.53, 0.85), as well as high rPA levels (OR = 0.53, 95% CI: 0.32, 0.88 for oral cavity, OR = 0.58, 95% CI: 0.38, 0.89 for pharynx). High rPA levels, however, is associated with higher risk of laryngeal cancer (OR = 1.73, 95% CI: 1.04, 2.88). Stratified analyses showed that such inverse association between moderate rPA and HNC was more evident among males (OR = 0.75, 95% CI: 0.62, 0.90), subjects ≥45 years (OR = 0.78, 95% CI: 0.66, 0.93), and ever smokers and ever drinkers (OR = 0.72, 95% CI: 0.59, 0.88). High rPA significantly reduces HNC risk among subject ≥45 years (OR = 0.66, 95% CI: 0.48, 0.91). Promoting rPA might be inversely associated with HNC.
authors.affiliation: Genetic Epidemiology and Public Health Genomics Unit, Institute of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Nicolotti
authors.forename: Shu-Chun
authors.initials: SC
authors.lastname: Chuang
authors.forename: Gabriella
authors.initials: G
authors.lastname: Cadoni
authors.forename: Dario
authors.initials: D
authors.lastname: Arzani
authors.forename: Livia
authors.initials: L
authors.lastname: Petrelli
authors.forename: Cristina
authors.initials: C
authors.lastname: Bosetti
authors.forename: Hermann
authors.initials: H
authors.lastname: Brenner
authors.forename: Satoyo
authors.initials: S
authors.lastname: Hosono
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Heiko
authors.initials: H
authors.lastname: Müller
authors.forename: Joshua
authors.initials: J
authors.lastname: Muscat
authors.forename: Gaetano
authors.initials: G
authors.lastname: Paludetti
authors.forename: Gualtiero
authors.initials: G
authors.lastname: Ricciardi
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Mia
authors.initials: M
authors.lastname: Hashibe
authors.forename: Stefania
authors.initials: S
authors.lastname: Boccia
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D016022:Case-Control Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D015337:Multicenter Studies as Topic; D016017:Odds Ratio; D011998:Recreation / Q000502:physiology*; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D000077195:Squamous Cell Carcinoma of Head and Neck