title: The prevalence of drug resistance mutations among treatment-naive HIV-infected individuals in Beijing, China.
abstract: To investigate the prevalence of HIV-1 genotypic mutations for drug resistance among patients in Beijing, blood samples from 145 newly confirmed (2006-2007), treatment-naive HIV-1-infected individuals were analyzed. Seven subtypes or CRF were subsequently determined and scored by the Stanford HIV Drug Resistance algorithm: CRF01_AE HIV-1 (27.6%), subtype B' (24.1%), CRF07_BC (21.4%), subtype B (20.7%), CRF08_BC (3.4%), subtype C (2.1%), and CRF06_cpx (0.7%). Eleven of the 145 subjects studied were found to harbor the strains resistant to either protease inhibitors (PIs) (3.4%), or nucleoside reverse transcriptase inhibitors (NRTIs) (2.1%), or nonnucleoside reverse transcriptase inhibitors (NNRTIs) (3.4%). Although the prevalence of drug resistance was relatively low among the treatment-naive HIV-1 patients in Beijing in comparison to those in industrialized countries, we will continue monitoring newly infected subjects for any potential alteration of the prevalence pattern to ensure the success of the ongoing scale-up of antiretroviral treatment.
authors.affiliation: National Institute for Viral Disease Control and Prevention, China Center for Disease Prevention and Control, Beijing, China.
authors.forename: Jing-rong
authors.initials: JR
authors.lastname: Ye
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Lu
authors.forename: Wei-shi
authors.initials: WS
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Ruo-lei
authors.initials: RL
authors.lastname: Xin
authors.forename: Shuang-qing
authors.initials: SQ
authors.lastname: Yu
authors.forename: Ting-chen
authors.initials: TC
authors.lastname: Wu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.forename: Xiong
authors.initials: X
authors.lastname: He
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D024882:Drug Resistance, Viral / Q000187:drug effects / Q000235:genetics*; D005260:Female; D005434:Flow Cytometry; D014644:Genetic Variation; D006679:HIV Seropositivity / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D015995:Prevalence; D018571:Sentinel Surveillance; D011795:Surveys and Questionnaires