title: Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.
abstract: Bioassay-guided fractionation of roots of Beilschmiedia tsangii led to the isolation of six new endiandric acid analogues: tsangibeilin A (1), tsangibeilin B (2), endiandramide A (3), endiandric acid K (4), endiandric acid L (5), and endiandramide B (6). Also isolated were two new lignans, beilschminol A (7) and tsangin C (8), and six known compounds. The structures of 1-8 were determined by spectroscopic techniques. Compounds 3 and 6 exhibited potent iNOS inhibitory activity, with IC(50) values of 9.59 and 16.40 μM, respectively.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
authors.forename: Yun-Ting
authors.initials: YT
authors.lastname: Huang
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.forename: Guei-Jane
authors.initials: GJ
authors.lastname: Wang
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Chu-Huang
authors.initials: CH
authors.lastname: Chen
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Yang
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D019770:Lauraceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013624:Taiwan
chemical_list: D000893:Anti-Inflammatory Agents; D002264:Carboxylic Acids; D017705:Lignans; C534861:endiandric acid; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II