title: Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.
abstract: Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatization to access a diverse array of compounds. This work led to the serendipitous discovery of a new method for the synthesis of a fused quinazolone ring system, which was applied to a one-step total synthesis of the quinazolinocarboline alkaloid rutaecarpine.
authors.affiliation: Department of Chemistry and Biochemistry, The Texas Institute for Drug and Diagnostic Development, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Brett A
authors.initials: BA
authors.lastname: Granger
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Kaneda
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin
mesh_terms: D015394:Molecular Structure; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D044005:Tetrahydroisoquinolines