title: The feasibility of growing cells of Saccharomyces cerevisiae for citronellol production in a continuous-closed-gas-loop bioreactor (CCGLB).
abstract: The present work aims to address the gas-phase biotransformation of geraniol into citronellol using growing cells of Saccharomyces cerevisiae (baker's yeast) in a continuous-closed-gas-loop bioreactor (CCGLB). This study revealed that the gaseous geraniol had a severe effect on the production of biomass during the growing cell biotransformation resulting in the decrease in the specific growth rate from 0.07 to 0.05 h⁻¹. The rate of reaction of the growing cell biotransformation was strongly affected by agitation and substrate flow rates. The highest citronellol concentration of 1.18 g/L and initial rate of reaction of 7.06 × 10⁻⁴ g/min g(cell) were obtained at 500 rpm and 8 L/min, respectively.
authors.affiliation: School of Chemical Engineering, Engineering Campus, Universiti Sains Malaysia, Seri Ampangan, 14300 Nibong Tebal, Penang, Malaysia.
authors.forename: Aimi Aishah
authors.initials: AA
authors.lastname: Arifin
authors.forename: Mashitah Mat
authors.initials: MM
authors.lastname: Don
authors.forename: Mohamad Hekarl
authors.initials: MH
authors.lastname: Uzir
mesh_terms: D000080462:Acyclic Monoterpenes; D018533:Biomass; D019149:Bioreactors; D001711:Biotransformation / Q000502:physiology; D002849:Chromatography, Gas; D005285:Fermentation; D039821:Monoterpenes / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000254:growth & development* / Q000378:metabolism*; D013053:Spectrophotometry; D013729:Terpenes / Q000378:metabolism
chemical_list: D000080462:Acyclic Monoterpenes; D039821:Monoterpenes; D013729:Terpenes; C007836:geraniol; C007078:citronellol