title: Endocrine regulation of neonatal hypoxia: role of glucose, oxygen, and epinephrine supplementation.
abstract: Responses of the endocrine system are vital in revealing the mechanisms of respiratory activities. The present study focused on changes in insulin and triiodothyronine concentration in serum, its receptors in the hearts of hypoxic neonatal rats and glucose, oxygen, and epinephrine resuscitated groups. The insulin concentration was significantly increased with a significant upregulation of receptors in hypoxic neonates. Triiodothyronine content and its receptors were significantly decreased in serum and the hearts of hypoxic neonates. The change in hormonal levels is an adaptive modification of the endocrine system to encounter the stress. The effectiveness of glucose resuscitation to hypoxic neonates was also reported.
authors.affiliation: Department of Biotechnology, Cochin University of Science and Technology, Cochin, India.
authors.forename: T R
authors.initials: TR
authors.lastname: Anju
authors.forename: M S
authors.initials: MS
authors.lastname: Nandhu
authors.forename: P
authors.initials: P
authors.lastname: Jes
authors.forename: C S
authors.initials: CS
authors.lastname: Paulose
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004703:Endocrine System / Q000502:physiology*; D004837:Epinephrine / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000378:metabolism* / Q000503:physiopathology; D007328:Insulin / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D007328:Insulin; D014284:Triiodothyronine; D005947:Glucose; D010100:Oxygen; D004837:Epinephrine