title: Complete remission of a relapsing adult T cell leukaemia following treatment of a secondary acute promyelocytic leukaemia: towards a reappraisal of arsenic trioxide and all-transretinoic acid?
abstract: Despite improvements in therapeutic options, human T cell lymphotropic virus type 1 (HTLV-1)-related adult T cell leukaemia/lymphoma (ATLL) has a dismal prognosis. The present report concerns the case of a multirelapsing ATLL that reached a complete remission following the treatment of a secondary acute promyelocytic leukaemia with cytarabine, anthracyclin, all-transretinoic acid and arsenic trioxide. This unexpected result with a multitreated/chemorefractory disease led us to reconsider the potential therapeutic benefits of arsenic trioxide, which has demonstrated efficacy against ATLL cells.
authors.affiliation: Hôpital Necker, Enfants Malades, Service d'Hématologie, 149, Rue de Sèvres, Paris, 75743 Cedex 15, France.
authors.forename: Marie-Olivia
authors.initials: MO
authors.lastname: Chandesris
authors.forename: David
authors.initials: D
authors.lastname: Ghez
authors.forename: Caroline
authors.initials: C
authors.lastname: Besson
authors.forename: Felipe
authors.initials: F
authors.lastname: Suarez
authors.forename: Richard
authors.initials: R
authors.lastname: Delarue
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Rubio
authors.forename: Ali
authors.initials: A
authors.lastname: Bazarbachi
authors.forename: Bruno
authors.initials: B
authors.lastname: Varet
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine