title: Return to youth with Sox17.
abstract: Maturation of hematopoietic stem cells (HSCs) from fetal to adult state and differentiation to progenitors are thought to follow a one-way street. In this issue of Genes & Development, He and colleagues (pp. 1613-1627) show that overexpression of Sox17 can convert adult multipotential progenitors to self-renewing HSCs that possess fetal properties. These findings challenge the irreversibility of hematopoietic development, and open up new perspectives to understand the different forms of HSC self-renewal at distinct stages of ontogeny and during transformation.
authors.affiliation: Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA.
authors.forename: Akanksha
authors.initials: A
authors.lastname: Chhabra
authors.forename: Hanna K A
authors.initials: HK
authors.lastname: Mikkola
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D005333:Fetus; D006410:Hematopoiesis / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism; D055760:SOXF Transcription Factors / Q000378:metabolism*
chemical_list: D055760:SOXF Transcription Factors