title: Electron ionization mass spectral study of oxo- and thio derivatives of minor tobacco alkaloids.
abstract: The electron-ionization mass spectra (EI-MS) of oxo- and thio-derivatives of minor tobacco alkaloids and structurally similar piperidine alkaloids, i.e. thiocotinine (1), 2'-oxo-N-methylanabasine (2), 2'-thio-N- methylanabasine (3), 2'-oxoanabasamine (4) and 2'-thioanabasamine (5) are discussed and general fragmentation routes of their molecular cations are proposed. Comparison of the data obtained for 1 with the EI-MS data of metameric metabolites of nicotine: 3'-hydroxycotinine, (A) and 5'-hydroxycotinine, (B) allows a differentiation between these metamers. The data will be useful for the identification of metabolites of alkaloids of these types in biological matrices.
authors.affiliation: Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland. beatakoz@amu.edu.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Jasiewicz
authors.forename: Marzena
authors.initials: M
authors.lastname: Wojciechowska-Nowak
authors.forename: Władysław
authors.initials: W
authors.lastname: Boczoń
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Wyrzykiewicz
mesh_terms: D000470:Alkaloids / Q000032:analysis* / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis* / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D014026:Nicotiana / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D010936:Plant Extracts