title: The delayed impact of parental age on offspring mortality in mice.
abstract: The certitude of death makes reproduction the foundation upon which all life-history strategies are based. Plasticity in the reproductive biology of organisms is an essential adaptive response to the capricious and hazardous environments of earth. In this article, we use data from a breeding colony for laboratory mice to examine the mortality risks of offspring born at the outer boundaries of their Dam's reproductive plasticity. Our results suggest that the mortality/survival characteristics of offspring are affected by both litter parity and offspring gender. Females born to young Dams have consistently longer life spans than females born to older Dams. Conversely, males are either not affected by parental age or have longer life spans when born to older Dams.
authors.affiliation: Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. bruce-carnes@ouhsc.edu
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Carnes
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Riesch
authors.forename: Ingo
authors.initials: I
authors.lastname: Schlupp
mesh_terms: D000818:Animals; D001947:Breeding; D005260:Female; D008098:Litter Size; D008136:Longevity; D008297:Male; D008423:Maternal Age; D051379:Mice; D008815:Mice, Inbred Strains; D010331:Paternal Age; D015996:Survival Rate