title: [Comparative study on pathology of non involuting congenital hemangioma and infantile hemangioma].
abstract: OBJECTIVE
  To distinguish non involuting congenital hemangioma (NICH) and infantile hemangioma (IH) by comparing the pathological structure and marker antigen expression.
  
  
  METHODS
  From Jan. 2005 to Aug. 2010, 39 paraffin-embedded samples, including 13 cases of NICH, 13 cases of proliferating IH and 13 cases of involuting IH, were collected from operation. Hematoxylin-eosin staining was used to observe the pathological structure. Immunohistochemical analysis was also performed to investigate the expression of Glut-1.
  
  
  RESULTS
  The lobules of capillaries were well-defined in NICH. The lobules were surrounded by abundant fibrous tissue. The capillaries were often large and integrity in NICH. There were few mitosis and apoptosis in endothelial cells and stromal cells in NICH. While in IH, the pathologic findings were totally different. Immunochemistry revealed that the Glut-1 was expressed in endothelial cells of IH, but not in NICH.
  
  
  CONCLUSIONS
  NICH has a steady histologic structure and low proliferation, while the endothelial cells in proliferative IH has a high proliferation. Glut-1 can be used as the reliable marker antigen for differential diagnosis of NICH and proliferative infantile hemangiomas.
authors.affiliation: Department of Plastic Surgery, Xinhua Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Song
authors.forename: Tian-xiang
authors.initials: TX
authors.lastname: Ouyang
authors.forename: Ying-ying
authors.initials: YY
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.forename: Hui-ping
authors.initials: HP
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
mesh_terms: D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D051272:Glucose Transporter Type 1 / Q000378:metabolism; D006391:Hemangioma / Q000151:congenital / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D051272:Glucose Transporter Type 1; C495677:SLC2A1 protein, human