title: CPP-ACP complex as a new adjunctive agent for remineralisation: a review.
abstract: In addition to regular professional oral hygiene visits and the application of appropriate preventive medications, successful preventive strategies involve oral health promotion, patient education and patient compliance. The Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) complex has been shown to remineralise tooth surfaces in situ when delivered in oral care products. This complex has a unique ability to deliver bio-available calcium and phosphate when they are needed most. The effectiveness of casein derivatives, specifically CCP-ACP, in caries prevention and lesion reversal has been supported by many controlled clinical studies. This review summarises the research on Casein phosphopeptide-amorphous calcium phosphate complex and provides information related to its benefit in dentistry. Further research is required to provide a scientifically supported recommendation for other clinical applications.
authors.affiliation: Department of Conservative Dentistry and Department of Prosthodontics, I.T.S. Centre for Dental Studies & Research Muradnagar, Ghaziabad, UP, India. drruchigupta@rediffmail.com
authors.forename: Ruchi
authors.initials: R
authors.lastname: Gupta
authors.forename: Vijay
authors.initials: V
authors.lastname: Prakash
mesh_terms: D000287:Administration, Topical; D001422:Bacterial Adhesion / Q000187:drug effects; D002130:Calcium Phosphates / Q000008:administration & dosage; D002327:Cariostatic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002364:Caseins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002638:Chewing Gum; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005459:Fluorides / Q000494:pharmacology; D006801:Humans; D009067:Mouthwashes / Q000494:pharmacology / Q000627:therapeutic use; D017001:Tooth Demineralization / Q000517:prevention & control; D014077:Tooth Erosion / Q000517:prevention & control; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D002130:Calcium Phosphates; D002327:Cariostatic Agents; D002364:Caseins; D002638:Chewing Gum; D009067:Mouthwashes; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; C020243:calcium phosphate; D005459:Fluorides