title: Patient-specific dosimetry in radionuclide therapy.
abstract: This study presents an attempt to compare individualised palliative treatment absorbed doses, by planar images data and Monte Carlo simulation, in two in vivo treatment cases, one of bone metastases and the other of liver lesions. Medical Internal Radiation Dose schema was employed to estimate the absorbed doses. Radiopharmaceutical volume distributions and absorbed doses in the lesions as well as in critical organs were also calculated by Monte Carlo simulation. Individualised planar data calculations remain the method of choice in internal dosimetry in nuclear medicine, but with the disadvantage of attenuation and scatter corrections lack and organ overlay. The overall error is about 7 % for planar data calculations compared with that using Monte Carlo simulation. Patient-specific three-dimensional dosimetric calculations using single-photon emission computed tomography with a parallel computed tomography study is proposed as an accurate internal dosimetry with the additional use of dose-volume histograms, which express dose distributions in cases with obvious inhomogeneity.
authors.affiliation: Radiation Physics Unit, A' Radiology Department, Kapodistrian University of Athens, 76 Vas Sophias Ave, Athens, Greece. mlyra@med.uoa.gr
authors.forename: Maria
authors.initials: M
authors.lastname: Lyra
authors.forename: Nefeli
authors.initials: N
authors.lastname: Lagopati
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Charalambatou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vamvakas
mesh_terms: D000465:Algorithms; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D009010:Monte Carlo Method; D015282:Octreotide / Q000627:therapeutic use; D057285:Precision Medicine; D016499:Radioimmunotherapy; D011874:Radiometry; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007205:Indium Radioisotopes; D015282:Octreotide