title: The use of drug-eluting stents in the management of transplant renal artery stenosis.
abstract: Transplant renal artery stenosis (TRAS) is a common occurrence following kidney transplantation with an incidence rate ranging from 6% to 23%. A single-center retrospective study was conducted to examine the use of drug-eluting stents (DES) in eligible patients with hemodynamically significant TRAS. Between March 2008 and January 2011, 12 patients were diagnosed with TRAS with reference vessel diameter measuring <5 mm and underwent endovascular intervention (EVI) with DES placement. TRAS was detected within the first year posttransplantation in a majority of these patients (83%) and manifested as hypertension (100%), allograft dysfunction (100%) and edema (58%). Procedural success rate was 100%. Patients were followed for a mean period of 16 ± 10 months. Blood pressure improved from a mean of 156/82 to 138/73 mmHg at the end of the follow-up period. In 11/12 patients, serum creatinine improved from 3.1 ± 1.3 mg/dL to 2.3 ± 0.5 mg/dL at the end of the follow-up period. TRAS of early onset is readily amenable to EVI with stent placement resulting in improvement in blood pressure control and allograft function.
authors.affiliation: Nephrology Cardiology Department of Medicine and Transplantation Services, School of Medicine, State University of New York, Stony Brook, NY, USA. mersema.abate@sunysb.edu
authors.forename: M T
authors.initials: MT
authors.lastname: Abate
authors.forename: J
authors.initials: J
authors.lastname: Kaur
authors.forename: H
authors.initials: H
authors.lastname: Suh
authors.forename: F
authors.initials: F
authors.lastname: Darras
authors.forename: A
authors.initials: A
authors.lastname: Mani
authors.forename: E P
authors.initials: EP
authors.lastname: Nord
mesh_terms: D000368:Aged; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000188:drug therapy* / Q000209:etiology; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents