title: MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function.
abstract: MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved, small, non-coding RNAs that post-transcriptionally regulate expression of their target genes. Emerging evidence indicates that miRNAs are important regulators that control the development, differentiation and function of different immune cells. Both CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells and invariant natural killer T (iNKT) cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and immunity. Here, we review the important roles of miRNAs in the development and function of iNKT and Treg cells.
authors.affiliation: Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Jang-June
authors.initials: JJ
authors.lastname: Park
authors.forename: Quanhui
authors.initials: Q
authors.lastname: Zheng
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dong
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Mi
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D053487:DEAD-box RNA Helicases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D055611:Natural Killer T-Cells / Q000276:immunology* / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics / Q000276:immunology*; D020871:RNA Stability / Q000276:immunology*; D012333:RNA, Messenger / Q000096:biosynthesis; D043244:Ribonuclease III / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D017634:Self Tolerance / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D035683:MicroRNAs; D012333:RNA, Messenger; C509781:Dicer1 protein, mouse; C513400:Drosha protein, mouse; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases