title: Socio-demographic factors, reproductive history and risk of osteoarthritis in a cohort of 4.6 million Danish women and men.
abstract: OBJECTIVE
  Studies addressing possible socio-demographic and reproductive factors in the aetiology of osteoarthritis (OA) are few. We studied possible influences of educational level, household income, marital status and parenting patterns on OA risk overall and at anatomical sites.
  
  
  METHODS
  We linked national register data about socio-demographic variables, reproductive histories and OA hospital contacts to a cohort of 4.6 million Danes. Ratios of first OA hospitalisation rates (RRs) were calculated using Poisson regression.
  
  
  RESULTS
  Overall, 100,437 women and 92,020 men had a first OA hospital contact during 91.5 million person-years between 1982 and 2008. Short education, low income and married status were significantly associated with increased OA risk, and persons with children were at higher risk of OA(overall) (RR=1.10 in women; RR=1.22 in men), OA(knee) (RRs 1.14; 1.28), OA(back) (RRs 1.18; 1.33), and OA(hand) (RRs 1.21; 1.43), but not of OA(hip) (RRs 0.96; 1.00) than persons without children. The RR of OA(overall) increased by a factor of 1.05 in women and 1.04 in men per additional child, most notably for OA(knee) in women (1.10 per child).
  
  
  CONCLUSIONS
  Risk of OA hospitalisation was highest among married persons and persons with short education or low income. The similar or even stronger associations with reproductive factors in men than women suggest that unmeasured lifestyle factors rather than biological factors associated with pregnancy might explain the higher OA risk in persons with children. However, the particularly strong association between parity and risk of OA(knee) in women is compatible with a role of pregnancy-associated factors.
authors.affiliation: Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. ktj@ssi.dk
authors.forename: K T
authors.initials: KT
authors.lastname: Jørgensen
authors.forename: B V
authors.initials: BV
authors.lastname: Pedersen
authors.forename: N M
authors.initials: NM
authors.lastname: Nielsen
authors.forename: A V
authors.initials: AV
authors.lastname: Hansen
authors.forename: S
authors.initials: S
authors.lastname: Jacobsen
authors.forename: M
authors.initials: M
authors.lastname: Frisch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003710:Demography; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000453:epidemiology*; D017584:Reproductive History; D012307:Risk Factors; D012959:Socioeconomic Factors; D055815:Young Adult