title: Sesquiterpenoids from the resinous exudates of Commiphora myrrha and their neuroprotective effects.
abstract: Ten new furanosesquiterpenoids, myrrhterpenoids A-J (1- 10), together with eight known analogues (11- 18), were isolated from the resinous exudates of COMMIPHORA MYRRHA. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by the ChemDraw 3D modeling using MM2. All isolated furanosesquiterpenes showed neuroprotective effects against MPP (+)-induced neuronal cell death in SH-SY5Y cells.
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Yushan
authors.initials: Y
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Cuizhou
authors.initials: C
authors.lastname: Liu
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Ma
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Wenbin
authors.initials: W
authors.lastname: Hou
authors.forename: Tiejun
authors.initials: T
authors.lastname: Zhang
mesh_terms: D016923:Cell Death; D002470:Cell Survival; D029744:Commiphora / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012116:Resins, Plant / Q000032:analysis / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D018696:Neuroprotective Agents; D012116:Resins, Plant; D012717:Sesquiterpenes