title: [Expression of glycoprotein non-metastatic melanoma protein B in prostate cancer and its significance].
abstract: OBJECTIVE
  To investigate the expression of glycoprotein non-metastatic melanoma protein B (GPNMB) in prostate cancer and its clinical significance.
  
  
  METHODS
  The expression of GPNMB was analysed in 63 prostate cancer and 3 heterosexual hyperplasia prostate tissue and 8 benign prostatic hyperplasia samples by immunohistochemical staining, with integral optical density(IOD) value representing expression level of positive cells.
  
  
  RESULTS
  The expression of GPNMB was lower in benign prostatic hyperplasia (BPH, IOD=70 017.49) than in Atypical hyperplasia (IOD=101 547.33, P=0.000 1) . The expression of GPNMB in tumor (IOD= 162 027.54) was higher than in non-tumor group (IOD=79 290.97), which included BPH and atypical hyperplasia (P=0.000 1). But GPNMB expression level was not positively elevated with degree of malignancy of prostate cancer. However, the expression of GPNMB in low pathological grading(IOD=177 944.30) was higher than that in high pathological grading(IOD=150 885.81, P=0.013).
  
  
  CONCLUSIONS
  The abnormal expression of GPNMB may play an important role in the development of prostate cancer and its detection may be useful for the early diagnosis of prostate cancer.
authors.affiliation: Department of Urology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Yun-bei
authors.initials: YB
authors.lastname: Xiao
authors.forename: Zheng-guo
authors.initials: ZG
authors.lastname: Qiao
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Zhang
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.forename: Yi-chang
authors.initials: YC
authors.lastname: Hao
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Yu
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C503042:GPNMB protein, human; D008562:Membrane Glycoproteins