title: Versatile flow-injection amperometric ion detector based on an interface between two immiscible electrolyte solutions: numerical and experimental characterization.
abstract: The present paper describes a flexible thin layer electrochemical flow cell for ultrasensitive amperometric detection at a supported interface between immiscible electrolyte solutions. Nanomolar detection limits were demonstrated using the cell design, and 3D finite element simulations allowed a detailed characterization of the flow cell. The cell design employed in the present work allowed the sensing oil membrane and the aqueous reference electrode to be placed in close contact, thereby minimizing cell resistance. The adjustable cell volume means that the same cell design can be used for different application with different requirement for detection limits and dynamic range. A disposable membrane was employed which reduces the need for surface cleaning and prevents sample carryover between different applications. For the lowest cell volumes the detection chamber approaches a thin layer electrochemical flow cell detector with a large surface to volume ratio.
authors.affiliation: Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Deryabina
authors.forename: Steen H
authors.initials: SH
authors.lastname: Hansen
authors.forename: Henrik
authors.initials: H
authors.lastname: Jensen
mesh_terms: D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004573:Electrolytes / Q000737:chemistry; D004987:Ethers / Q000737:chemistry; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods*; D008567:Membranes, Artificial; D011145:Polyvinyls / Q000737:chemistry; D012996:Solutions; D013499:Surface Properties; D014867:Water / Q000737:chemistry; D005465:Fluorocarbon Polymers
chemical_list: D004573:Electrolytes; D004987:Ethers; D008567:Membranes, Artificial; D011145:Polyvinyls; D012996:Solutions; D014867:Water; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers