title: A prion-like trigger of antiviral signaling.
abstract: The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al. (2011) now report that virus infection induces a conformational change in MAVS, leading to the prion-like formation of functional self-aggregates that provide a sensitive trigger for antiviral signaling.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Junqiang
authors.initials: J
authors.lastname: Ye
authors.forename: Tom
authors.initials: T
authors.lastname: Maniatis