title: Targeting chemokine receptors in chronic inflammatory diseases: an extensive review.
abstract: The traffic of the different types of immune cells is an important aspect in the immune response. Chemokines are soluble peptides that are able to attract cells by interaction with chemokine receptors on their target cells. Several different chemokines and receptors exist enabling the specific trafficking of different immune cells. In chronic inflammatory disorders there is abundance of immune cells present at the inflammatory site. This review focuses on the role of chemokine receptors in chronic inflammatory disorders of the lungs, intestine, joints, skin and nervous system and the potential of targeting these receptors as therapeutic intervention in these disorders.
authors.affiliation: Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands.
authors.forename: Pim J
authors.initials: PJ
authors.lastname: Koelink
authors.forename: Saskia A
authors.initials: SA
authors.lastname: Overbeek
authors.forename: Saskia
authors.initials: S
authors.lastname: Braber
authors.forename: Petra
authors.initials: P
authors.lastname: de Kruijf
authors.forename: Gert
authors.initials: G
authors.lastname: Folkerts
authors.forename: Martine J
authors.initials: MJ
authors.lastname: Smit
authors.forename: Aletta D
authors.initials: AD
authors.lastname: Kraneveld
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D018925:Chemokines / Q000276:immunology*; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D008171:Lung Diseases / Q000276:immunology; D011565:Psoriasis / Q000276:immunology; D019707:Receptors, Chemokine / Q000276:immunology*
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine