title: Olopatadine 0.6% nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis.
abstract: BACKGROUND
  Vasomotor rhinitis (VMR) is a hypersensitivity syndrome with heightened reactivity to environmental triggers.
  
  
  METHODS
  Twenty-two patients with severe VMR were treated nasally with either normal saline or 0.6% olopatadine and challenged nasally with a hyperosmolar mannitol solution.
  
  
  RESULTS
  Treatment with 0.6% olopatadine resulted in an improvement in instantaneous nasal symptom scores at 5 and 30 minutes (p < 0.01) compared with baseline and at 30 minutes after hyperosmolar challenge compared with saline-pretreated individuals (p < 0.01). There was also an improvement in nasal peak inspiratory flow rate at 30 minutes after hyperosmolar challenge compared with saline-pretreated individuals (p < 0.01).
  
  
  CONCLUSIONS
  In this patient population 0.6% olopatadine appears to be efficacious in symptom reduction in VMR and protects from hyperosmolar challenge.
authors.affiliation: Department of Clinical Medicine, Griffith University, Southport, Australia. pksm@mac.com
authors.forename: Peter K
authors.initials: PK
authors.lastname: Smith
authors.forename: Joel
authors.initials: J
authors.lastname: Collins
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002211:Capsaicin / Q000008:administration & dosage; D003990:Dibenzoxepins / Q000008:administration & dosage* / Q000009:adverse effects; D018450:Disease Progression; D005260:Female; D006801:Humans; D007320:Inspiratory Capacity / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000517:prevention & control; D009299:Nasal Provocation Tests; D059085:Nasal Sprays; D000069605:Olopatadine Hydrochloride; D012223:Rhinitis, Vasomotor / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D003990:Dibenzoxepins; D059085:Nasal Sprays; D000069605:Olopatadine Hydrochloride; D002211:Capsaicin