title: Cell growth and cell cycle in Saccharomyces cerevisiae: basic regulatory design and protein-protein interaction network.
abstract: In this review we summarize the major connections between cell growth and cell cycle in the model eukaryote Saccharomyces cerevisiae. In S. cerevisiae regulation of cell cycle progression is achieved predominantly during a narrow interval in the late G1 phase known as START (Pringle and Hartwell, 1981). At START a yeast cell integrates environmental and internal signals (such as nutrient availability, presence of pheromone, attainment of a critical size, status of the metabolic machinery) and decides whether to enter a new cell cycle or to undertake an alternative developmental program. Several signaling pathways, that act to connect the nutritional status to cellular actions, are briefly outlined. A Growth & Cycle interaction network has been manually curated. More than one fifth of the edges within the Growth & Cycle network connect Growth and Cycle proteins, indicating a strong interconnection between the processes of cell growth and cell cycle. The backbone of the Growth & Cycle network is composed of middle-degree nodes suggesting that it shares some properties with HOT networks. The development of multi-scale modeling and simulation analysis will help to elucidate relevant central features of growth and cycle as well as to identify their system-level properties. Confident collaborative efforts involving different expertises will allow to construct consensus, integrated models effectively linking the processes of cell growth and cell cycle, ultimately contributing to shed more light also on diseases in which an altered proliferation ability is observed, such as cancer.
authors.affiliation: Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Milano, Italy. lilia.alberghina@unimib.it
authors.forename: Lilia
authors.initials: L
authors.lastname: Alberghina
authors.forename: Gabriella
authors.initials: G
authors.lastname: Mavelli
authors.forename: Guido
authors.initials: G
authors.lastname: Drovandi
authors.forename: Pasquale
authors.initials: P
authors.lastname: Palumbo
authors.forename: Stefania
authors.initials: S
authors.lastname: Pessina
authors.forename: Farida
authors.initials: F
authors.lastname: Tripodi
authors.forename: Paola
authors.initials: P
authors.lastname: Coccetti
authors.forename: Marco
authors.initials: M
authors.lastname: Vanoni
mesh_terms: D002453:Cell Cycle / Q000502:physiology; D015966:Gene Expression Regulation, Fungal; D008954:Models, Biological; D060066:Protein Interaction Maps; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D049490:Systems Biology