title: Bioactivities of Chuquiraga straminea sandwith.
abstract: Methanolic extracts of Chuquiraga straminea Sandwith, subfamily Barnadesioideae (Asteraceae) showed the presence of quercetin-3-O-glucoside, quercetin-3-O-rutinoside, kaempferol, kaempferol-3-O-glucoside and kaempferol-3-O-rutinoside. Antioxidant and antimicrobial activity was determined. The total extracts showed antioxidant activity by DPPH and ABTS method (SC50 14.5 to 34.9 microg/mL). A significantly positive correlation was observed between the antioxidant activity and the total phenolics (R2 > 0.93). The extracts were active against ten methicillin resistant and sensitive Staphylococcus aureus strains isolated from nosocomial infection (MIC values between 200 to 800 microg/mL). These preliminary studies are highly interesting as they open new ways for further applications in the treatment of infections by methicillin resistant S. aureus.
authors.affiliation: Facultad de Ciencias Naturales e Instituto Miguel Lillo, UNT, Fundación Miguel Lillo, CONICET Miguel Lillo 205/251, (4000) San Miguel de Tucumán, Tucumán, Argentina.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Mendiondo
authors.forename: Berta E
authors.initials: BE
authors.lastname: Juáreza
authors.forename: Catiana
authors.initials: C
authors.lastname: Zampini
authors.forename: Maria Inés
authors.initials: MI
authors.lastname: Isla
authors.forename: Roxana
authors.initials: R
authors.lastname: Ordoñez
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001118:Argentina; D019659:Asteraceae / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D003428:Cross Infection / Q000382:microbiology; D020834:Ethnopharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010851:Picrates / Q000737:chemistry; D010865:Pilot Projects; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D005419:Flavonoids; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl