title: Two-year clinical experience with tomotherapy: the French national cancer institute project on implementing new technology.
abstract: The pooled 2-year clinical experience using three tomotherapy units installed in France in 2007 is presented. Treatment indications and protocols were devised for each disease site and were the result of a consensus. A total of 642 patients were treated for central nervous system, head and neck, thoracic, abdominal, and pelvic tumors. Overall, grade 3, 4, and 5 acute toxicity was 10.7%, 0.3%, and 0.2%, respectively. Grade 3 chronic toxicity was 1.2%. There was no grade 4 or 5 chronic toxicity. The use of tomotherapy in a broad clinical practice is safe, and acute and chronic toxicity both are acceptable for all anatomical locations.
authors.affiliation: Department of Radiation Oncology, Hôpital Européen Georges Pompidou, Paris Descartes University, Sorbonne Cité Paris, France. philippe.giraud@egp.aphp.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Giraud
authors.forename: Guy
authors.initials: G
authors.lastname: Kantor
authors.forename: Michael
authors.initials: M
authors.lastname: Yassa
authors.forename: Sofia
authors.initials: S
authors.lastname: Zefkili
authors.forename: Catherine
authors.initials: C
authors.lastname: Dejean
authors.forename: Albert
authors.initials: A
authors.lastname: Lisbona
authors.forename: François
authors.initials: F
authors.lastname: Campana
authors.forename: Marc-André
authors.initials: MA
authors.lastname: Mahé
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*