title: Functional and highly porous scaffolds for biomedical applications.
abstract: Highly porous functional scaffolds were obtained from linear and cross-linked multifunctional poly(ε-caprolactone) and poly(L-lactide). The polymers were synthesized by ring-opening polymerization of ε-caprolactone and L-lactide using poly(but-2-ene-1,4-diyl malonate) (PBM) as macroinitiator and stannous 2-ethylhexanoate. The presence of a double bond in each repeating unit of PBM enabled cross-linking of both scaffolds and films. Soft and flexible scaffolds were created from cross-linked PBM. The mechanical properties of scaffolds and films were evaluated under cyclic conditions, with a focus on the compositions and molecular weights. It was obvious that PBM in the polymers and its cross-linking ability resulted in tunable material characteristics, including an increased ability to recover after repeated loading.
authors.affiliation: Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology, SE-100 44, Stockholm, Sweden.
authors.forename: Therese
authors.initials: T
authors.lastname: Tyson
authors.forename: Sofia
authors.initials: S
authors.lastname: Målberg
authors.forename: Veronica
authors.initials: V
authors.lastname: Wåtz
authors.forename: Anna
authors.initials: A
authors.lastname: Finne-Wistrand
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Albertsson
mesh_terms: D019245:Compressive Strength; D008314:Malonates / Q000737:chemistry; D008422:Materials Testing; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry; D058105:Polymerization; D016062:Porosity; D044968:Regenerative Medicine / Q000379:methods*; D013718:Tensile Strength; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D055114:X-Ray Microtomography
chemical_list: D008314:Malonates; D011091:Polyesters; C016240:polycaprolactone; C033616:poly(lactide); C030290:malonic acid