title: Breast cancer in female-to-male transsexuals: two cases with a review of physiology and management.
abstract: Testosterone is important for the development of secondary sexual characteristics in female-to-male (FtM) transsexuals, but it may increase breast cancer risk. To date, only one breast cancer case has been reported in the literature in a FtM transsexual after 10 years of testosterone therapy. We describe 2 cases of breast cancers diagnosed in FtM transsexuals who have been treated with supraphysiological doses of testosterone. Our 2 cases demonstrate the unique issues that concern the management of FtM transsexuals with breast cancer and examine possible roles of testosterone in the development of breast cancer.
authors.affiliation: Department of Medical Oncology, Beth Israel Medical Center, 325 W. 15th Street, New York, NY 10011, USA. tshao@chpnet.org
authors.forename: Theresa
authors.initials: T
authors.lastname: Shao
authors.forename: Michael L
authors.initials: ML
authors.lastname: Grossbard
authors.forename: Paula
authors.initials: P
authors.lastname: Klein
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D013739:Testosterone / Q000008:administration & dosage* / Q000009:adverse effects; D014189:Transsexualism
chemical_list: D013739:Testosterone