title: Achillinin A, a cytotoxic guaianolide from the flower of Yarrow, Achillea millefolium.
abstract: Achillinin A (2β,3β-epoxy-1α,4β,10α-trihydroxyguai-11(13)-en-12,6α-olide, 1), a new guaianolide isolated from the flower of Achillea millefolium, exhibited potential antiproliferative activity to A549, RERF-LC-kj and QG-90 cells with 50% inhibitory concentration (IC(50)) values of 5.8, 10 and 0.31 µM, respectively.
authors.affiliation: School of Basic Medicine, Hebei Medical University, Hebei Province, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Man-Li
authors.initials: ML
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Cong
authors.forename: Si-Ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Dong
authors.forename: Françoise
authors.initials: F
authors.lastname: Sauriol
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Huo
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Shi
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Gu
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kiyota
mesh_terms: D031162:Achillea / Q000737:chemistry*; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D035264:Flowers / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012717:Sesquiterpenes