title: Genetics of inflammation in the gastrointestinal tract and how it can cause cancer.
abstract: Genetic epidemiology is an important discipline that is helping to unravel the aetiology and pathogenesis of complex human diseases. In the context of gastrointestinal malignancy, the paradigm model of host genetic influence on disease outcome is H. pylori-associated gastric adenocarcinoma. This cancer represents a classic example of an inflammation-induced malignancy and highlights the importance of host genetics in disease development. This chapter gives an insight into how genetic epidemiology can play an important role in the development of gastric cancer. Increasing our understanding of host genetics in cancer development may allow particularly susceptible individuals to be targeted for screening or treatment to reduce risk of future malignant transformation.
authors.affiliation: Gastrointestinal Research Group, Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK.
authors.forename: Mairi H
authors.initials: MH
authors.lastname: McLean
authors.forename: Emad M
authors.initials: EM
authors.lastname: El-Omar
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D051546:Cyclooxygenase 2 / Q000235:genetics; D005759:Gastroenteritis / Q000150:complications* / Q000235:genetics*; D005770:Gastrointestinal Neoplasms / Q000209:etiology*; D005802:Genes, MHC Class II / Q000235:genetics / Q000276:immunology; D016481:Helicobacter Infections / Q000150:complications* / Q000235:genetics / Q000276:immunology; D016480:Helicobacter pylori / Q000378:metabolism / Q000472:pathogenicity; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics; D016209:Interleukin-8 / Q000235:genetics; D013274:Stomach Neoplasms / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology
chemical_list: D053583:Interleukin-1beta; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D051546:Cyclooxygenase 2