title: Mycoplasma pneumoniae induces interleukin-8 production via the epidermal growth factor receptor pathway.
abstract: In mycoplasmal pneumonia, the bronchi are histopathologically filled with polymorphonuclear leukocytes. The EGFR pathway is involved in IL-8 production. We investigated the contribution of the EGFR pathway to IL-8 production by bronchial epithelial cells (A549) stimulated with Mp-Ag. The IL-8 production by A549 cells stimulated with Mp-Ag was decreased by the addition of an EGFR kinase inhibitor or transfection with small interfering RNA against EGFR. The levels of epiregulin mRNA in A549 cells were increased by stimulation with Mp-Ag. In conclusion, the EFGR pathway participates in IL-8 production by bronchial epithelial cells stimulated with Mp-Ag.
authors.affiliation: Department of Immunology, Kyorin University Faculty of Health Sciences, 476 Miyashita, Hachioji, Tokyo 192-8508, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Arae
authors.forename: Masako
authors.initials: M
authors.lastname: Hirata
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kurata
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kamiya
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Taguchi
mesh_terms: D002460:Cell Line; D004815:Epidermal Growth Factor / Q000235:genetics / Q000276:immunology; D066260:Epiregulin; D066246:ErbB Receptors / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics / Q000276:immunology*; D009177:Mycoplasma pneumoniae / Q000502:physiology*; D011019:Pneumonia, Mycoplasma / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D015398:Signal Transduction
chemical_list: C587880:EREG protein, human; D066260:Epiregulin; D016209:Interleukin-8; D004815:Epidermal Growth Factor; D066246:ErbB Receptors