title: Function, structure and mechanism of bacterial photosensory LOV proteins.
abstract: LOV (light, oxygen or voltage) domains are protein photosensors that are conserved in bacteria, archaea, plants and fungi, and detect blue light via a flavin cofactor. LOV domains are present in both chemotrophic and phototrophic bacterial species, in which they are found amino-terminally of signalling and regulatory domains such as sensor histidine kinases, diguanylate cyclases-phosphodiesterases, DNA-binding domains and regulators of RNA polymerase σ-factors. In this Review, we describe the current state of knowledge about the function of bacterial LOV proteins, the structural basis of LOV domain-mediated signal transduction, and the use of LOV domains as genetically encoded photoswitches in synthetic biology.
authors.affiliation: Department of Biochemistry and Molecular Biology, The University of Chicago, Illinois 60637, USA.
authors.forename: Julien
authors.initials: J
authors.lastname: Herrou
authors.forename: Sean
authors.initials: S
authors.lastname: Crosson
mesh_terms: D001105:Archaea / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019843:Archaeal Proteins / Q000737:chemistry / Q000378:metabolism; D001419:Bacteria / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D056931:Cryptochromes; D005415:Flavins / Q000378:metabolism; D005420:Flavoproteins / Q000737:chemistry / Q000378:metabolism; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism; D005658:Fungi / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008027:Light; D056949:Phototropins / Q000378:metabolism; D018524:Phototropism; D010940:Plant Proteins / Q000737:chemistry / Q000378:metabolism; D010944:Plants / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D058615:Synthetic Biology
chemical_list: D019843:Archaeal Proteins; D001426:Bacterial Proteins; D056931:Cryptochromes; D005415:Flavins; D005420:Flavoproteins; D005656:Fungal Proteins; D056949:Phototropins; D010940:Plant Proteins