title: Feline urate urolithiasis: a retrospective study of 159 cases.
abstract: The objective of the study was to characterize the signalment, clinicopathologic data, and diagnostic imaging of cats with urate urolithiasis, as well as the salts of uric acid present in the uroliths. A retrospective analysis of feline urate uroliths submitted to the GV Ling Urinary Stone Analysis Laboratory between 2000 and 2008 was included. From these data, records were assimilated from referring veterinarians (143); furthermore, all recorded cases from within the William R Pritchard Veterinary Medical Teaching Hospital (16) were included. Median values for the complete blood count and chemistry panels available were within the reference intervals, when provided, with only a few outliers present. Of all cases evaluated, seven had a portosystemic shunt (PSS). Cats with urate uroliths and a PSS were younger than cats without a PSS (2 years vs 7 years). The pathogenesis of urate uroliths in cats is poorly understood. Most cats were not completely evaluated for a PSS, however, clinicopathologic parameters indicating hepatic dysfunction were seldom noted; more sensitive diagnostics such as serum bile acids were rarely performed to confirm or negate the presence of a shunt. Studies are warranted to evaluate pathogenesis of urate uroliths to tailor proper management and breeding strategies.
authors.affiliation: Veterinary Medical Teaching Hospital, University of California-Davis, Davis, CA 95616, USA. jddear@ucdavis.edu
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Dear
authors.forename: Ryojj
authors.initials: R
authors.lastname: Shiraki
authors.forename: Annette L
authors.initials: AL
authors.lastname: Ruby
authors.forename: Jodi L
authors.initials: JL
authors.lastname: Westropp
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood; D001772:Blood Cell Count / Q000662:veterinary; D002140:California / Q000453:epidemiology; D002371:Cat Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D002415:Cats; D005260:Female; D005402:Fistula / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D012189:Retrospective Studies; D014527:Uric Acid / Q000032:analysis; D052878:Urolithiasis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary*
chemical_list: D001647:Bile Acids and Salts; D014527:Uric Acid