title: Effects of working-memory training on striatal dopamine release.
abstract: Updating of working memory has been associated with striato-frontal brain regions and phasic dopaminergic neurotransmission. We assessed raclopride binding to striatal dopamine (DA) D2 receptors during a letter-updating task and a control condition before and after 5 weeks of updating training. Results showed that updating affected DA activity before training and that training further increased striatal DA release during updating. These findings highlight the pivotal role of transient neural processes associated with D2 receptor activity in working memory.
authors.affiliation: Aging Research Center, Karolinska Institute, 171 77 Stockholm, Sweden. lars.backman.1@ki.se
authors.forename: Lars
authors.initials: L
authors.lastname: Bäckman
authors.forename: Lars
authors.initials: L
authors.lastname: Nyberg
authors.forename: Anna
authors.initials: A
authors.lastname: Soveri
authors.forename: Jarkko
authors.initials: J
authors.lastname: Johansson
authors.forename: Micael
authors.initials: M
authors.lastname: Andersson
authors.forename: Erika
authors.initials: E
authors.lastname: Dahlin
authors.forename: Anna S
authors.initials: AS
authors.lastname: Neely
authors.forename: Jere
authors.initials: J
authors.lastname: Virta
authors.forename: Matti
authors.initials: M
authors.lastname: Laine
authors.forename: Juha O
authors.initials: JO
authors.lastname: Rinne
mesh_terms: D000328:Adult; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D007858:Learning; D008297:Male; D008570:Memory, Short-Term; D049268:Positron-Emission Tomography; D020891:Raclopride / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D055815:Young Adult
chemical_list: D017448:Receptors, Dopamine D2; D020891:Raclopride; D004298:Dopamine