title: [Effect of 6 MeV radiotherapy on secondary Echinococcus multilocularis infection in rats].
abstract: OBJECTIVE
  To explore the effect of 6-MeV X-ray radiotherapy on secondary Echinococcus multilocularis infection in rats.
  
  
  METHODS
  Female SD rats were used to develop a secondary infection model, and then randomly divided into experimental group and control group (5/group). Rats in experimental group received two irradiations at 7-day intervals with the same dose (20 Gy) which applied with 6-MeV ray. The rats in control group did not receive any treatment. At one month after the second irradiation, the pathomorphological changes of E. multilocularis cysts were observed.
  
  
  RESULTS
  Cysts in experimental group showed different degrees of damage, including that the laminated layer and germinal layer became swollen and separated from each other, brood capsules and protoscoleces were rare. The structure of cysts was normal in control group, laminated layer and germinal layer were clear, and there were many protoscoleces in the brood capsule.
  
  
  CONCLUSIONS
  6 MeV radiotherapy can inhibit the growth of E. multilocularis.
authors.affiliation: Cancer Center of the First Teaching Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Yong-xing
authors.initials: YX
authors.lastname: Bao
authors.forename: Yue-fen
authors.initials: YF
authors.lastname: Zhang
authors.forename: Ya-qiong
authors.initials: YQ
authors.lastname: Ni
authors.forename: Zeng-ru
authors.initials: ZR
authors.lastname: Xie
authors.forename: Hong-zhi
authors.initials: HZ
authors.lastname: Qi
authors.forename: Rui
authors.initials: R
authors.lastname: Mao
authors.forename: Yu-gang
authors.initials: YG
authors.lastname: Yang
authors.forename: Hao
authors.initials: H
authors.lastname: Wen
mesh_terms: D000818:Animals; D004443:Echinococcosis / Q000469:parasitology / Q000532:radiotherapy*; D048210:Echinococcus multilocularis / Q000528:radiation effects*; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley