title: Successful treatment of brainstem blastomycosis with fluconazole.
abstract: The lipid formulation of amphotericin B is the initial drug of choice for central nervous system blastomycosis, but it is costly and associated with significant toxicity. This case report details a patient with primary pulmonary blastomycosis with dissemination to the skin, one joint, and the brainstem that was successfully treated solely with high-dose fluconazole.
authors.affiliation: Infectious Disease Section, Gundersen Lutheran Health System, 1900 South Avenue, La Crosse, WI 54601, USA.
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Brick
authors.forename: William A
authors.initials: WA
authors.lastname: Agger
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001758:Blastomyces; D001759:Blastomycosis / Q000188:drug therapy*; D001933:Brain Stem / Q000382:microbiology / Q000473:pathology*; D020314:Central Nervous System Fungal Infections / Q000188:drug therapy*; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole