title: The association of hs-CRP with fasting and postprandial plasma lipids in patients with type 2 diabetes is disrupted by dietary monounsaturated fatty acids.
abstract: The aim of the study was to evaluate whether two dietary approaches recommended for diabetes mellitus and cardiovascular prevention-high-MUFA or complex carbohydrates/fiber-differently influence inflammation. A 4-week crossover study in 12 individuals with type 2 diabetes was performed. Fasting and postprandial hs-CRP plasma levels were not significantly different after a high-carbohydrate/high-fiber/low-glycemic index (CHO/fiber) and a high-MUFA diet. Compared with fasting, hs-CRP levels decreased significantly after the MUFA but not after the CHO/fiber meal. Triglyceride-rich lipoproteins were significantly lower after the CHO/fiber than the MUFA diet. At fasting and postprandially, hs-CRP correlated with triglyceride in whole plasma, chylomicrons, small and large VLDL after the CHO/fiber but not after the MUFA diet. In conclusion, a MUFA-rich diet and a carbohydrate/fiber-rich diet induced similar effects on plasma hs-CRP concentrations. However, these dietary approaches seem to influence hs-CRP levels through different mechanisms. i.e., direct acute postprandial effects by MUFA and triglyceride-rich lipoproteins mediated effects by CHO/fiber.
authors.affiliation: Department of Clinical and Experimental Medicine, Federico II University, Via S Pansini 5, 80131, Naples, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bozzetto
authors.forename: C
authors.initials: C
authors.lastname: De Natale
authors.forename: L
authors.initials: L
authors.lastname: Di Capua
authors.forename: G
authors.initials: G
authors.lastname: Della Corte
authors.forename: L
authors.initials: L
authors.lastname: Patti
authors.forename: S
authors.initials: S
authors.lastname: Maione
authors.forename: G
authors.initials: G
authors.lastname: Riccardi
authors.forename: A A
authors.initials: AA
authors.lastname: Rivellese
authors.forename: G
authors.initials: G
authors.lastname: Annuzzi
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage; D005215:Fasting / Q000097:blood*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D038321:Glycemic Index; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood
chemical_list: D002097:C-Reactive Protein; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D005229:Fatty Acids, Monounsaturated; D006442:Glycated Hemoglobin; D008055:Lipids; D014280:Triglycerides