title: Analgesic activity of aqueous leaf extract of Phyllanthus amarus.
abstract: Various doses of the aqueous extract of Phyllanthus amarus (AEPA) were investigated for analgesic and anti-inflammatory activities using both thermal and chemical models of pain assessment in rats. The extract caused a significant (P < 0.05) dose related increase inhibition of the carrageenan-induced paw oedema in the rats. The inhibition produced by 200 mg/kg AEPA (70.20%) was significantly higher than that of the reference drug (Acetylsalicylic acid). The extract produced a marked analgesic activity by inhibiting both early and late phases of pain stimulus in Formalin-induced paw licking rats and also a significant and dose related increase in inhibiting the mean tail immersion duration (MITD) at varying water bath temperature (50 degrees C, 55 degrees C and 60 degrees C). This study thus established the anti-inflammatory and analgesic activities of Phyllanthus amarus.
authors.affiliation: Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Nigeria. bolasunkanmi45@yahoo.com
authors.forename: B O
authors.initials: BO
authors.lastname: Iranloye
authors.forename: V B
authors.initials: VB
authors.lastname: Owoyele
authors.forename: O R
authors.initials: OR
authors.lastname: Kelani
authors.forename: S B
authors.initials: SB
authors.lastname: Olaleye
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D029803:Phyllanthus / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014867:Water
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D014867:Water; D002351:Carrageenan