title: Abrikossoff tumor: does it origin in swchann cells? Case report.
abstract: BACKGROUND
  Abrikossoff tumor is an uncommon neoplasia, benign in most of the cases, that affects soft tissues, skin, and oral mucosa. Between 1% and 2% of cases are malignant and, in these cases, outcome is usually fatal. Between 5% and 25% of patients have multiple lesions.
  
  
  METHODS
  A 52-year old Caucasian male was referred to the Plastic Surgery Department with a lesion in the tongue. A wide surgical excision was subsequently performed and the final pathologic diagnosis was Abrikossoff's tumor.
  
  
  CONCLUSIONS
  The pathogenesis of this tumor has long been subject of research and debate, and its origin has still to be clearly established. At the time, Abrikossoff proposed a myogenic origin, later studies supported a neural differentiation. According to the data in the literature the expression of S-100, that we found in our case, sustains the hypothesis that Abrikossoff tumor has origin in the Schwann's cells.
  
  
  CONCLUSIONS
  In our opinion, Abrikossoff tumor has origin in the Schwann's cells. However familial cases, congenital cases, and multiple lesions are uncommon, and it is worth stressing that this tumor has a good prognosis but every patient with Abrikossoff tumor should undergo a complete physical examination to rule out the presence of multiple associated tumors and possible visceral involvement.
authors.affiliation: Department of Dermatology and Plastic, Reconstructive and Aesthetic Surgery, University of Rome "Sapienza" Policlinico Umberto I, Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Tarallo
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cigna
authors.forename: Pasquale
authors.initials: P
authors.lastname: Fino
authors.forename: Federico
authors.initials: F
authors.lastname: Lo Torto
authors.forename: Alessia
authors.initials: A
authors.lastname: Pollastrini
authors.forename: Nicolò
authors.initials: N
authors.lastname: Scuderi
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D012583:Schwann Cells / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D014062:Tongue Neoplasms / Q000473:pathology*