title: [Experience in treatment of patients with neuropathic facial pain using ziconotide].
abstract: We report on the intrathecal use of ziconotide in three patients with idiopathic facial pain after surgery of the mouth, jaw or face and one patient with neuropathic pain after damage of the lingual nerve. The therapy was successful in three patients but one patient with idiopathic facial pain had pain relief only during the test phase of ziconotide with an external pump and not after implanting the Synchromed® pump. With intrathecal morphine therapy this patient achieved good pain relief. We recommend that patients with neuropathic facial pain should be treated with ziconotide after implementation of guideline-based therapy. In the test phase the ziconotide dose should be increased by 0.6 µg/day per week after an initial dose of 0.6-1.2 µg/day to avoid side-effects.
authors.affiliation: Klinik für Schmerz- und Palliativmedizin, Klinikum St.-Marien-Hospital Lünen. drlux@web.de
authors.forename: E A
authors.initials: EA
authors.lastname: Lux
authors.forename: D
authors.initials: D
authors.lastname: Rasche
mesh_terms: D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D015521:Ethmoid Sinusitis / Q000601:surgery; D005156:Facial Neuralgia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal; D061222:Lingual Nerve Injuries / Q000188:drug therapy; D015523:Maxillary Sinusitis / Q000601:surgery; D009078:Mucocele / Q000601:surgery; D010147:Pain Measurement / Q000187:drug effects; D010149:Postoperative Pain / Q000188:drug therapy*; D014081:Tooth Extraction; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000188:drug therapy; D055815:Young Adult; D020960:omega-Conotoxins / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D018712:Analgesics, Non-Narcotic; D020960:omega-Conotoxins; C078452:ziconotide