title: [Effect of vitamin E supplementation on alpha-tocopherol levels in human colostrum].
abstract: OBJECTIVE
  To assess the levels of alpha-tocopherol in human colostrum following supplementation with capsules containing vitamin A plus synthetic vitamin E.
  
  
  METHODS
  Thirty healthy women about to give birth were recruited from a public maternity hospital. After overnight fasting, blood samples as well as colostrum samples (2 mL) were collected. After the first collection, the women received supplementation with a capsule containing retinyl palmitate (200,000 IU or 60 mg) plus synthetic vitamin E (49.4 mg dl-alpha tocopherol). Twenty-four hours after supplementation, a second 2 mL colostrum sample was collected after overnight fasting.
  
  
  RESULTS
  The serum concentration of alpha-tocopherol was 1 042,9 ± 319.0 µg/dL. The concentration of alpha-tocopherol in colostrum before supplementation was 155.4 ± 811.0 µg/dL, vs. 1 396.3 ± 862.2 µg/dL 24 hours after supplementation (P > 0.05). A correlation was found between fasting levels of alpha-tocopherol in colostrum before supplementation and 24 hours after supplementation (P = 0.001; r = 0.58), but not between the concentrations in serum and colostrum.
  
  
  CONCLUSIONS
  There was no increase in the levels of alpha-tocopherol in colostrum 24 hours after supplementation. This suggests that supplementation with synthetic vitamin E is not advantageous. However, the present results also suggest that if the nutritional state is adequate prior to supplementation, more tocopherol will be available in colostrum after supplementation. Further studies should be carried out to investigate the effects of supplementation with the natural form of alpha-tocopherol.
authors.affiliation: Departamento de Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil. robertod@ufrnet.br
authors.forename: Roberto
authors.initials: R
authors.lastname: Dimenstein
authors.forename: Larissa
authors.initials: L
authors.lastname: Lira
authors.forename: Ana C P
authors.initials: AC
authors.lastname: Medeiros
authors.forename: Lahyana R F
authors.initials: LR
authors.lastname: Cunha
authors.forename: Tânia L M
authors.initials: TL
authors.lastname: Stamford
mesh_terms: D000328:Adult; D001835:Body Weight; D001938:Brazil / Q000453:epidemiology; D003126:Colostrum / Q000737:chemistry*; D003430:Cross-Sectional Studies; D019587:Dietary Supplements; D004224:Diterpenes; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008895:Milk, Human / Q000737:chemistry*; D011247:Pregnancy / Q000097:blood*; D000084562:Retinyl Esters; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives; D014810:Vitamin E / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D055815:Young Adult; D024502:alpha-Tocopherol / Q000097:blood*
chemical_list: D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; D014810:Vitamin E; C014794:retinol palmitate; D024502:alpha-Tocopherol