title: The assessment of left ventricular systolic asynchrony in patients with primary hyperparathyroidism.
abstract: OBJECTIVE
  Primary hyperparathyroidism (PHP) is associated with a variety of cardiovascular disturbances such as left ventricular (LV) hypertrophy, diastolic cardiac dysfunction, and hypertension. LV asynchrony is defined as the loss of the simultaneous peak contraction of corresponding cardiac segments. The objective of this study was to assess systolic asynchrony in patients with overt hyperparthyroidism.
  
  
  METHODS
  Asynchrony was evaluated in 22 patients with PHP and 24 controls. All the patients and controls were subjected to a tissue synchronization imaging (TSI). The time to regional peak systolic tissue velocity (Ts) in LV by the six-basal-six-midsegmental model was measured on ejection phase TSI images and four TSI parameters of systolic asynchrony were computed.
  
  
  RESULTS
  All TSI parameters of LV asynchrony increased in patients with PHP patients compared to the controls: the standard deviation (SD) of the 12 LV segments Ts (37.3±20.6 vs. 21.5±11.1, P=0.01); the maximal difference in Ts between any 2 of the 12 LV segments (111.2±59.8 vs. 70.2±32.1, P=0.01); the SD of the 6 basal LV segments (42.9±36.4 vs. 18.5±13, P=0.003); and the maximal difference in Ts between any 2 of the 6 basal LV segments (89.6±50.5 vs. 48±31.1, P=0.003).
  
  
  CONCLUSIONS
  Patients with PHP show an evidence of LV asynchrony by TSI. Asynchrony may contribute to the harmful cardiovascular effects of PHP.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. akiris79@yahoo.com
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Kırış
authors.forename: Cihangir
authors.initials: C
authors.lastname: Erem
authors.forename: Gülhanım
authors.initials: G
authors.lastname: Kırış
authors.forename: Irfan
authors.initials: I
authors.lastname: Nuhoğlu
authors.forename: Kayıhan
authors.initials: K
authors.lastname: Karaman
authors.forename: Nadim
authors.initials: N
authors.lastname: Civan
authors.forename: Cihan
authors.initials: C
authors.lastname: Örem
authors.forename: Ismet
authors.initials: I
authors.lastname: Durmuş
authors.forename: Merih
authors.initials: M
authors.lastname: Kutlu
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000503:physiopathology
chemical_list: D015415:Biomarkers