title: Aseptic tissue necrosis and chronic inflammation after irrigation of penetrating hand wounds using Octenisept®.
abstract: Penetrating hand wounds are common and these are managed by thorough debridement. However, stab wounds without evidence of divided structures are often treated with irrigation using antiseptic substances, antibiotic therapy, and immobilization. Octenisept® (Schülke & Mayr Ltd) is a widely used antiseptic agent for disinfection of acute or chronic wounds. It has a broad spectrum of antiseptic efficacy and has become an antiseptic of first choice in many hospitals. Within a few months, four patients presented to us with chronic inflammation and severe tissue necrosis after irrigation of penetrating hand wounds with Octenisept®. Repeated surgery and debridement was required in all patients. Wound healing was prolonged and patients had persisting oedema. Penetrating hand wounds must not be irrigated with Octenisept®.
authors.affiliation: Department of Plastic and Hand Surgery, Inselspital Berne, University Hospital, Berne, Switzerland. torsten.franz@insel.ch
authors.forename: T
authors.initials: T
authors.lastname: Franz
authors.forename: E
authors.initials: E
authors.lastname: Vögelin
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000009:adverse effects*; D003646:Debridement; D005260:Female; D006230:Hand Injuries / Q000188:drug therapy*; D006801:Humans; D007097:Imines; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D009336:Necrosis / Q000139:chemically induced; D011725:Pyridines / Q000009:adverse effects*; D007507:Therapeutic Irrigation; D014945:Wound Healing / Q000187:drug effects; D014950:Wounds, Penetrating / Q000188:drug therapy*
chemical_list: D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; C034213:octenidine