title: Conversional synthesis and cytotoxic evaluation of novel taxoid analogs.
abstract: Four novel taxoid analogs were conversionally synthesized from the C(19)-diterpenoid alkaloid deltaline, and their cytotoxic activities were evaluated against a small panel of cancer cell lines.
authors.affiliation: Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Song
authors.forename: Qiao-Hong
authors.initials: QH
authors.lastname: Chen
authors.forename: Xue-Ke
authors.initials: XK
authors.lastname: She
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Chen
authors.forename: Feng-Peng
authors.initials: FP
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry*; D000077143:Docetaxel; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry; D043823:Taxoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D004224:Diterpenes; D043823:Taxoids; C528313:deltaline; D000077143:Docetaxel; D017239:Paclitaxel