title: Sagittal spino-pelvic alignment failures following three column thoracic osteotomy for adult spinal deformity.
abstract: OBJECTIVE
  Three column thoracic osteotomy (TCTO) is effective to correct rigid thoracic deformities, however, reasons for residual postoperative spinal deformity are poorly defined. Our objective was to evaluate risk factors for poor spino-pelvic alignment (SPA) following TCTO for adult spinal deformity (ASD).
  
  
  METHODS
  Multicenter, retrospective radiographic analysis of ASD patients treated with TCTO. Radiographic measures included: correction at the osteotomy site, thoracic kyphosis (TK), lumbar lordosis (LL), sagittal vertical axis (SVA), pelvic tilt (PT), and pelvic incidence (PI). Final SVA and PT were assessed to determine if ideal SPA (SVA < 4 cm, PT < 25°) was achieved. Differences between the ideal (IDEAL) and failed (FAIL) SPA groups were evaluated.
  
  
  RESULTS
  A total of 41 consecutive ASD patients treated with TCTO were evaluated. TCTO significantly decreased TK, maximum coronal Cobb angle, SVA and PT (P < 0.05). Ideal SPA was achieved in 32 (78%) and failed in 9 (22%) patients. The IDEAL and FAIL groups had similar total fusion levels and similar focal, SVA and PT correction (P > 0.05). FAIL group had larger pre- and post-operative SVA, PT and PI and a smaller LL than IDEAL (P < 0.05).
  
  
  CONCLUSIONS
  Poor SPA occurred in 22% of TCTO patients despite similar operative procedures and deformity correction as patients in the IDEAL group. Greater pre-operative PT and SVA predicted failed post-operative SPA. Alternative or additional correction procedures should be considered when planning TCTO for patients with large sagittal global malalignment, otherwise patients are at risk for suboptimal correction and poor outcomes.
authors.affiliation: New York University Hospital for Joint Diseases, 306 East 15th Street, New York, NY 10003, USA.
authors.forename: Virginie
authors.initials: V
authors.lastname: Lafage
authors.forename: Justin S
authors.initials: JS
authors.lastname: Smith
authors.forename: Shay
authors.initials: S
authors.lastname: Bess
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Schwab
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Ames
authors.forename: Eric
authors.initials: E
authors.lastname: Klineberg
authors.forename: Vincent
authors.initials: V
authors.lastname: Arlet
authors.forename: Richard
authors.initials: R
authors.lastname: Hostin
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Burton
authors.forename: Christopher I
authors.initials: CI
authors.lastname: Shaffrey
mesh_terms: D000328:Adult; D017760:Bone Malalignment / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007738:Kyphosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008141:Lordosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010027:Osteotomy / Q000009:adverse effects* / Q000379:methods; D010384:Pelvic Bones / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011859:Radiography; D012189:Retrospective Studies; D012307:Risk Factors; D013121:Spinal Curvatures / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D013904:Thoracic Vertebrae / Q000601:surgery*; D017211:Treatment Failure; D014481:United States