title: Habitual resistance exercise and endothelial ischemia-reperfusion injury in young adults.
abstract: Resistance exercise involves muscular contractions that can render downstream tissues ischemic and may precondition the vasculature against ischemia-reperfusion (IR) injury, but it is unknown if habitual resistance exercise protects against IR injury in humans. We determined the magnitude and recovery from endothelial IR injury induced by forearm occlusion in 22 healthy young sedentary and resistance-trained adults. After IR injury, brachial artery flow-mediated dilation (FMD) significantly decreased by 36% in sedentary, but not resistance-trained subjects and fully recovered within 45 min. Though HDL-cholesterol, handgrip strength and systolic blood pressure were significantly associated with FMD 15 min after IR injury, the change in FMD from before to 15 min after IR injury was not associated with any subject characteristics. These results are consistent with the notion that habitual resistance exercise may protect against endothelial IR injury in young adults, presumably through effects analogous to ischemic preconditioning.
authors.affiliation: Cardiovascular Aging Research Laboratory, Department of Kinesiology and Health Education, The University of Texas at Austin, Bellmont Hall 222, D3700, Austin, TX 78712, USA. Allison.DeVan@colorado.edu
authors.forename: Allison E
authors.initials: AE
authors.lastname: DeVan
authors.forename: Daniel
authors.initials: D
authors.lastname: Umpierre
authors.forename: Hsin-Fu
authors.initials: HF
authors.lastname: Lin
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Harrison
authors.forename: Takashi
authors.initials: T
authors.lastname: Tarumi
authors.forename: Mandeep
authors.initials: M
authors.lastname: Dhindsa
authors.forename: Stacy D
authors.initials: SD
authors.lastname: Hunter
authors.forename: Shawn M
authors.initials: SM
authors.lastname: Sommerlad
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D001916:Brachial Artery / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D005260:Female; D005542:Forearm / Q000098:blood supply; D018737:Hand Strength; D006801:Humans; D019194:Ischemic Preconditioning / Q000379:methods; D008297:Male; D015427:Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control; D014664:Vasodilation / Q000502:physiology; D055815:Young Adult