title: Exposure to bisphosphonates and risk of colorectal cancer: a population-based nested case-control study.
abstract: BACKGROUND
  Chemoprevention is a potentially attractive strategy for decreasing the burden of colorectal cancer (CRC). Preclinical studies suggest that bisphosphonates (BPs) may have direct antitumour effects against CRC. The objective of this study was to determine the effect of exposure to BPs on the incidence of CRC.
  
  
  METHODS
  The Manitoba Cancer Registry was used to identify patients who were diagnosed with CRC from 2000 to 2009 who had been living in Manitoba for at least 5 years before diagnosis (cases). Each case was matched to 10 controls of similar age, sex, and duration of residence in Manitoba using incidence density sampling. Exposure to BPs was determined using the provincial Drug Program Information Network database. Conditional logistic regression analysis was performed to determine the effect of exposure to BPs on CRC incidence with adjustment for health care use, medical procedures (including lower gastrointestinal endoscopy), socioeconomic status, and pre-existing health conditions.
  
  
  RESULTS
  In total, 5425 patients with CRC were matched to 54,242 controls. In the multivariate analysis, exposure to BPs was associated with a reduction in the risk of CRC (2-13 BP prescriptions over ≥5 years: odds ratio [OR] 0.84; 95% confidence interval [CI], 0.71-1.00; ≥14 BP prescriptions over ≥5 years: OR, 0.78; 95% CI, 0.65-0.94). When the effect of specific BP agents was evaluated, the effect was significant only for exposure to risedronic acid (OR, 0.50; 95% CI, 0.30-0.85). There was no significant effect of increasing duration or cumulative dose of alendronic acid.
  
  
  CONCLUSIONS
  The results from this study suggested that exposure to BPs, especially risedronic acid, may be associated with a decreased risk of developing CRC.
authors.affiliation: Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. singh@cc.umanitoba.ca
authors.forename: Harminder
authors.initials: H
authors.lastname: Singh
authors.forename: Zoann
authors.initials: Z
authors.lastname: Nugent
authors.forename: Alain
authors.initials: A
authors.lastname: Demers
authors.forename: Salaheddin
authors.initials: S
authors.lastname: Mahmud
authors.forename: Charles
authors.initials: C
authors.lastname: Bernstein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D015897:Comorbidity; D004164:Diphosphonates / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016273:Occupational Exposure / Q000706:statistics & numerical data; D011153:Population; D012042:Registries; D012307:Risk Factors
chemical_list: D004164:Diphosphonates