title: A new hydroxylated nonaprenylhydroquinone from the Mediterranean marine sponge Sarcotragus spinosulus.
abstract: Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.
authors.affiliation: Chemistry Laboratory of Biomolecules and Aroma, Nice Institute of Chemistry, UFR of Sciences, University of Nice-Sophia Antipolis, UMR-CNRS 6001, Parc Valrose, F-06108 Nice Cedex 02, France.|Marseille Oceanology Center, University of Aix-Marseille, CNRS UMR 6540 DIMAR, Endoume Marine Station, Batterie des Lions Street, 13007 Marseille, France.
authors.forename: Charline
authors.initials: C
authors.lastname: Abed
authors.affiliation: Chemistry Laboratory of Biomolecules and Aroma, Nice Institute of Chemistry, UFR of Sciences, University of Nice-Sophia Antipolis, UMR-CNRS 6001, Parc Valrose, F-06108 Nice Cedex 02, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Legrave
authors.affiliation: INSERM UMR 895, Team 2, Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Saint-Antoine de Ginestiere Road, BP2 3194, 06204 Nice Cedex 3, France.
authors.forename: Maeva
authors.initials: M
authors.lastname: Dufies
authors.affiliation: INSERM UMR 895, Team 2, Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Saint-Antoine de Ginestiere Road, BP2 3194, 06204 Nice Cedex 3, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Robert
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Guérineau
authors.affiliation: Marseille Oceanology Center, University of Aix-Marseille, CNRS UMR 6540 DIMAR, Endoume Marine Station, Batterie des Lions Street, 13007 Marseille, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Vacelet
authors.affiliation: INSERM UMR 895, Team 2, Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Saint-Antoine de Ginestiere Road, BP2 3194, 06204 Nice Cedex 3, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Auberger
authors.affiliation: Chemistry Laboratory of Biomolecules and Aroma, Nice Institute of Chemistry, UFR of Sciences, University of Nice-Sophia Antipolis, UMR-CNRS 6001, Parc Valrose, F-06108 Nice Cedex 02, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Amade
authors.affiliation: Chemistry Laboratory of Biomolecules and Aroma, Nice Institute of Chemistry, UFR of Sciences, University of Nice-Sophia Antipolis, UMR-CNRS 6001, Parc Valrose, F-06108 Nice Cedex 02, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mehiri
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D006900:Hydroxylation; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D015394:Molecular Structure; D009792:Oceans and Seas; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D006873:Hydroquinones; D010936:Plant Extracts