title: Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load.
abstract: The Tsimane of lowland Bolivia are an indigenous forager-farmer population living under conditions resembling pre-industrial European populations, with high infectious morbidity, high infection and inflammation, and shortened life expectancy. Analysis of 917 persons ages 5 to 60+ showed that allele frequencies of 9 SNPs examined in the apolipoprotein E (apoE), C-reactive protein (CRP), and interleukin-6 (IL-6) genes differed from some European, African, and north Asian-derived populations. The apoE2 allele was absent, whereas four SNPs related to CRP and IL-6 were monomorphic: CRP (rs1800947, rs3093061, and rs3093062) and IL-6 (rs1800795). No significant differences in apoE, CRP, and IL-6 variants across age were found CRP levels were higher in carriers of two CRP proinflammatory SNPs, whereas they were lower in carriers of apoE4. Taken together the evidence for (1) different allele frequencies between the Tsimane and other populations and (2) the correlations of CRP and apoE alleles with blood CRP may suggest that these variants are under selection in response to a high infection environment.
authors.affiliation: Office of Population Research, Princeton University, Princeton, New Jersey 08544, USA. svasunil@princetin.edu
authors.forename: Sarinnapha
authors.initials: S
authors.lastname: Vasunilashorn
authors.forename: Caleb E
authors.initials: CE
authors.lastname: Finch
authors.forename: Eileen M
authors.initials: EM
authors.lastname: Crimmins
authors.forename: Suvi A
authors.initials: SA
authors.lastname: Vikman
authors.forename: Jonathan
authors.initials: J
authors.lastname: Stieglitz
authors.forename: Michael
authors.initials: M
authors.lastname: Gurven
authors.forename: Hillard
authors.initials: H
authors.lastname: Kaplan
authors.forename: Hooman
authors.initials: H
authors.lastname: Allayee
mesh_terms: D000293:Adolescent; D000328:Adult; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D001838:Bolivia / Q000453:epidemiology; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003141:Communicable Diseases / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D016018:Least-Squares Analysis; D008017:Life Expectancy / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide
chemical_list: D001057:Apolipoproteins E; D015850:Interleukin-6; D002097:C-Reactive Protein