title: Risk factors for human rabies in China.
abstract: In China, we have witnessed an increasing incidence of rabies in recent years and the number of deaths ranked first among the 39 notifiable infectious diseases. We conducted a case-control study to identify risk factors for human rabies infection and disease to recommend prevention and treatment among people exposed to rabies. Exposure site, pre-exposure prophylaxis and post-exposure prophylaxis were significantly associated with rabies infection. Exposure site at upper limb and trunk or at lower limb were at lower risk as compared with head-exposed patients. The OR was 0.09(95% CI: 0.009-0.93) and 0.01(95% CI: 0.001-0.115) respectively. Pre-exposure prophylaxis (OR = 0.05, 95% CI: 0.03-0.11) and post-exposure prophylaxis (OR = 0.02, 95% CI: 0.01-0.40) were both protective factors as compared with no prophylaxis. For patients who had post-exposure prophylaxis, dose for the first injection and immunity procedure were significantly associated with rabies infection.
authors.affiliation: Zhejiang Center for Disease Control and Prevention, Hangzhou City, China. 87235011@163.com
authors.forename: Z
authors.initials: Z
authors.lastname: Gong
authors.forename: F
authors.initials: F
authors.lastname: He
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001733:Bites and Stings / Q000150:complications; D016022:Case-Control Studies; D002415:Cats; D002681:China / Q000453:epidemiology; D004285:Dogs; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D045969:Mustelidae / Q000821:virology; D056990:Post-Exposure Prophylaxis / Q000379:methods*; D011818:Rabies / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D011819:Rabies Vaccines / Q000008:administration & dosage*; D011820:Rabies virus / Q000276:immunology*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult; D015047:Zoonoses
chemical_list: D011819:Rabies Vaccines