title: Death and dessert: nutrient signalling pathways and ageing.
abstract: Reduction in nutrient intake without malnutrition can delay ageing and extend healthy life in diverse organisms from yeast to primates. This effect can be recapitulated by genetic or pharmacological dampening of the signal through nutrient signalling pathways, making them a promising target for intervention into human ageing and age-related diseases. Here we review the current knowledge of the interactions between nutrient signalling pathways and ageing, focusing on the findings emerged in the past few years.
authors.affiliation: Institute of Healthy Ageing, and GEE, University College London, London WC1E 6BT, UK.
authors.forename: Nazif
authors.initials: N
authors.lastname: Alic
authors.forename: Linda
authors.initials: L
authors.lastname: Partridge
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D031204:Caloric Restriction; D004032:Diet; D006801:Humans; D008136:Longevity; D015398:Signal Transduction