title: Rapid and sensitive determination of benzaldehyde arising from benzyl alcohol used as preservative in an injectable formulation solution using dispersive liquid-liquid microextraction followed by gas chromatography.
abstract: A rapid and sensitive method has been developed for the determination of benzaldehyde, a toxic oxidation product of the widely used preservative and co-solvent benzyl alcohol in injectable formulations of non-steroidal anti-inflammatory drugs, diclofenac, vitamin B-complex and Voltaren injection solutions by using dispersive liquid-liquid microextraction followed by gas chromatography. This method involves the use of an appropriate mixture of extraction solvent (43.0 µL 1,2-dichloroethane) and disperser solvent (1.0 mL acetonitrile) for the formation of a cloudy solution in a 5.0-mL aqueous sample containing benzaldehyde. The linear range was 1.0-1000 µg L(-1), and the limit of detection was 0.2 µg L(-1) for benzaldehyde.
authors.affiliation: Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran. chem.mashayekhi@tonekaboniau.ac.ir
authors.forename: Hossein Ali
authors.initials: HA
authors.lastname: Mashayekhi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rezaee
authors.forename: Shirin Sadeghi
authors.initials: SS
authors.lastname: Garmaroudi
authors.forename: Naser
authors.initials: N
authors.lastname: Montazeri
authors.forename: Seyed Javad
authors.initials: SJ
authors.lastname: Ahmadi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry; D001547:Benzaldehydes / Q000032:analysis* / Q000737:chemistry; D019905:Benzyl Alcohol / Q000737:chemistry*; D002849:Chromatography, Gas; D007267:Injections; D059627:Liquid Phase Microextraction; D011310:Preservatives, Pharmaceutical / Q000032:analysis / Q000737:chemistry; D012996:Solutions
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001547:Benzaldehydes; D011310:Preservatives, Pharmaceutical; D012996:Solutions; D019905:Benzyl Alcohol; C032175:benzaldehyde