title: Metal-based new sulfonamides: Design, synthesis, antibacterial, antifungal, and cytotoxic properties.
abstract: Cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes with 5-chlorosalicyladehyde derived Schiff base sulfonamides have been synthesized and characterized. Structure and bonding nature of all the synthesized compounds have been deduced from physical, analytical, and spectral (IR, (1)H NMR, (13)C NMR, Mass, electronic) data. An octahedral geometry has been proposed for all the metal complexes. The ligands and their metal complexes have been screened for their in vitro antibacterial, antifungal, and cytotoxic properties and results are reported.
authors.affiliation: Department of Chemistry, Bahauddin Zakariya University, Multan 60800, Pakistan. dr.zahidchohan@gmail.com
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
authors.forename: Hazoor A
authors.initials: HA
authors.lastname: Shad
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects*; D001419:Bacteria / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D007814:Larva / Q000166:cytology / Q000187:drug effects; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D012545:Schiff Bases / Q000737:chemistry; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry*; D018675:Toxicity Tests
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D008024:Ligands; D019216:Metals, Heavy; D009942:Organometallic Compounds; D012545:Schiff Bases; D013449:Sulfonamides