title: Randomized controlled trial of restrictive fluid management in transient tachypnea of the newborn.
abstract: OBJECTIVE
  To determine the effect of mild fluid restriction on the hospital course of neonates with transient tachypnea of the newborn (TTN).
  
  
  METHODS
  In this pilot prospective randomized controlled trial of 64 late preterm and term neonates diagnosed with TTN at a single tertiary care hospital in the United States, patients were randomized to receive standard fluid management or mild fluid restriction. The primary outcome was duration of respiratory support. Secondary outcomes were duration of admission to the intensive care unit, time to first enteral feed, and total and composite hospital costs. Results were analyzed by t-test, χ(2) test, Kaplan-Meier estimation, and proportional hazards regression.
  
  
  RESULTS
  Fluid restriction did not cause adverse events or unsafe dehydration. Fluid management strategy did not affect primary or secondary outcomes in the total study population. Fluid restriction significantly reduced the duration of respiratory support (P = .008) and hospitalization costs (P = .017) in neonates with severe TTN.
  
  
  CONCLUSIONS
  Mild fluid restriction appears to be safe in late preterm and term neonates with uncomplicated TTN. Fluid restriction may be of benefit in decreasing the duration of respiratory support and reducing hospitalization costs in term and late preterm neonates with uncomplicated severe TTN.
authors.affiliation: Mount Sinai Medical Center, New York, NY, USA. Annemarie.Stroustrup@mssm.edu
authors.forename: Annemarie
authors.initials: A
authors.lastname: Stroustrup
authors.forename: Leonardo
authors.initials: L
authors.lastname: Trasande
authors.forename: Ian R
authors.initials: IR
authors.lastname: Holzman
mesh_terms: D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D059245:Transient Tachypnea of the Newborn / Q000628:therapy*