title: Resting tremor in Parkinson disease: a negative predictor of levodopa-induced dyskinesia.
abstract: BACKGROUND
  It is unclear whether patients with different clinical subtypes of Parkinson disease (PD) differ in their risk of developing levodopa-induced dyskinesia (LID) and whether resting tremor is negatively correlated with this risk.
  
  
  OBJECTIVE
  To determine whether resting tremor as an initial manifestation of PD negatively correlated with subsequent occurrence and severity of LID and to study the correlations between LID and other epidemiological factors (eg, age at onset of PD and duration of PD).
  
  
  METHODS
  Logistic regression analysis was used to determine predictive factors of LID. Spearman rank correlations between LID and epidemiological factors and motor signs (including tremor) were calculated.
  
  
  METHODS
  Institutional tertiary referral center for movement disorders.
  
  
  METHODS
  Cohort of 85 patients with PD.
  
  
  METHODS
  Occurrence of LID according to the Unified Parkinson Disease Rating Scale part IV.
  
  
  RESULTS
  Resting tremor as an initial manifestation of PD was associated with reduced risk of developing LID independent of other predictors of LID (duration of PD, axial signs, and levodopa dose).
  
  
  CONCLUSIONS
  Resting tremor as an initial manifestation of PD predicts lower probability of developing LID under levodopa treatment.
authors.affiliation: Movement Disorders Center, Department of Neurology, “Inselspital” Berne University Hospital, University of Berne, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kipfer
authors.forename: Marianne A
authors.initials: MA
authors.lastname: Stephan
authors.forename: W M Michael
authors.initials: WM
authors.lastname: Schüpbach
authors.forename: Pietro
authors.initials: P
authors.lastname: Ballinari
authors.forename: Alain
authors.initials: A
authors.lastname: Kaelin-Lang
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects; D015331:Cohort Studies; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000453:epidemiology; D011237:Predictive Value of Tests; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D014202:Tremor / Q000175:diagnosis* / Q000453:epidemiology
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa