title: Stereoselective Copper-Catalyzed Intramolecular Alkene Aminooxygenation: Effects of Substrate and Ligand Structure on Selectivity.
abstract: A new protocol for diastereoselective copper-catalyzed intra-molecular alkene aminooxygenation, which provides methyleneoxy-functionalized disubstituted pyrrolidines and five-membered cyclic ureas from the corresponding γ-alkenyl sulfonamides and N-allylureas, is reported. In addition, some success was achieved in enantioselective desymmetrizations reactions. We discovered that the level of enantioselectivity and diastereoselectivity could be tuned by choice of copper(II) ligands and substrate N-substituent.
authors.affiliation: Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260-3000, USA.
authors.forename: Monissa C
authors.initials: MC
authors.lastname: Paderes
authors.forename: Sherry R
authors.initials: SR
authors.lastname: Chemler