title: Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct.
abstract: To conquer complex and devastating diseases such as cancer, more coordinated and combined attack strategies are needed. We suggest that these can be beautifully achieved by using nanoconstruct design. We present an example showing that neuroblastoma cells are selectively killed by a nanoconstruct that specifically targets neuroblastoma cells, pushes cells to the vulnerable phase of the cell cycle, and greatly enhances radiation-induced cell death. The success of this multipronged attack approach launched by cell-embedded nanoconstructs demonstrates the power and flexibility of nanotechnology in treating cancer, a difficult task for a small molecule.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan, China.
authors.forename: Peifu
authors.initials: P
authors.lastname: Jiao
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.forename: Mario
authors.initials: M
authors.lastname: Otto
authors.forename: Qingxin
authors.initials: Q
authors.lastname: Mu
authors.forename: Liwen
authors.initials: L
authors.lastname: Li
authors.forename: Gaoxing
authors.initials: G
authors.lastname: Su
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Butch
authors.forename: Scott E
authors.initials: SE
authors.lastname: Snyder
authors.forename: Guibin
authors.initials: G
authors.lastname: Jiang
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D049329:Nanostructures / Q000032:analysis / Q000737:chemistry*; D009447:Neuroblastoma / Q000628:therapy*; D017239:Paclitaxel / Q000008:administration & dosage*; D014965:X-Rays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel