title: The pathophysiology of acute pain: animal models.
abstract: OBJECTIVE
  Trauma, surgery, and burns are three common clinical scenarios that are associated with significant acute pain. This review describes the pathophysiology of acute pain utilizing three preclinical models: surgery, burn, and fracture.
  
  
  RESULTS
  In general, there is greater interest directed toward peripheral mediators of acute pain. Studies indicate that treatment against nerve growth factor, interleukins, and ischemic-like mediators may provide valuable avenues for treatment of acute pain. By targeting the periphery, analgesic therapies may have reduced side-effects.
  
  
  CONCLUSIONS
  Peripheral mediators of acute pain can vary depending upon the type of injury. Treatment aimed toward those mediators specific to the injury may improve acute pain management in the future. It will be important to translate these findings into clinical trials in the future.
authors.affiliation: Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Brennan
mesh_terms: D059787:Acute Pain / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D002056:Burns / Q000150:complications; D004195:Disease Models, Animal; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D010149:Postoperative Pain / Q000503:physiopathology
chemical_list: D000700:Analgesics