title: Swerilactones L-O, secoiridoids with C₁₂ and C₁₃ skeletons from Swertia mileensis.
abstract: Swerilactones L-O (1-4), four unusual secoiridoids with unprecedented C₁₂ and C₁₃ skeletons, were isolated from the traditional Chinese herb Swertia mileensis. Compounds 1 and 2 had moderate inhibitory activities against the secretion of hepatitis B virus surface antigen (IC₅₀ = 1.47 and 1.20 mM, with SI < 1 and 1.53, respectively) and hepatitis B virus e antigen (IC₅₀ = 0.88 and >2.69 mM, with SI 1.62 and <1, respectively) in an antihepatitis B virus assay on the Hep G 2.2.15 cell line in vitro.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, People's Republic of China.
authors.forename: Chang-An
authors.initials: CA
authors.lastname: Geng
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Ma
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006514:Hepatitis B Surface Antigens / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D029967:Swertia / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D006514:Hepatitis B Surface Antigens; D039823:Iridoids; D007783:Lactones