title: Cross-coupling in flow.
abstract: Until recently, cross-coupling reactions have been exclusively performed in batch processes. With the advent of microfluidics, significant effort has been devoted to develop a wide variety of continuous-flow techniques to facilitate organic synthesis. In this critical review, we attempt to give an overview of the different continuous-flow methodologies that have been developed and utilized for cross-coupling reactions. In addition, we attempt to point out the advantages of continuous-flow when compared with their batch counterparts (246 references).
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. tnoel@mit.edu
authors.forename: Timothy
authors.initials: T
authors.lastname: Noël
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D002244:Carbon / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D009584:Nitrogen / Q000737:chemistry
chemical_list: D002244:Carbon; D009584:Nitrogen