title: Arterial stiffness and 24 h ambulatory blood pressure monitoring in young healthy volunteers: the early vascular ageing Aristotle University Thessaloniki Study (EVA-ARIS Study).
abstract: Differences in 24 h blood pressure (BP) monitoring parameters such as average 24 h BP, day to night BP ratio and BP variability could have an impact in arterial stiffness. The study hypothesis was that despite similar average BP values in ambulatory blood pressure monitoring subjects with increased 24 h BP variability may have increased arterial stiffness. The study population consisted of 115 consecutive young healthy volunteers. Carotid-femoral PWV was measured in all subjects. Clinic BP was measured and an appropriate cuff was fitted on the non-dominant arm of each subject for a 24 h ambulatory blood pressure monitoring session. Waist to hip ratio as well as BMI was measured. Family history and smoking habits were recorded. In univariate analysis, estimated carotid-femoral PWV showed a significant correlation with age, weight, waist circumference, height, clinic systolic and diastolic BP, 24-h systolic and diastolic BP, 24-h pulse pressure, 24-h systolic and diastolic BP variability, daytime systolic and diastolic BP, daytime pulse pressure, daytime systolic and diastolic BP variability, nighttime systolic BP, nighttime pulse pressure and nighttime systolic BP variability. In multivariate regression analysis, age (B=0.95, P<0.001) and 24 h systolic BP variability (B=0.28, P<0.001) were independent determinanats of arterial stiffness. In conclusions, increased 24 h systolic BP variability is associated with arterial stiffness in young healthy volunteers. Pulse wave velocity in a young healthy population is useful to identify determinants of premature arterial stiffness, thus further elucidating the aspects of early vascular ageing.
authors.affiliation: Hypertension Center, 3rd Department of Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Greece. vkotsis@auth.gr
authors.forename: Vasilios
authors.initials: V
authors.lastname: Kotsis
authors.forename: Stella
authors.initials: S
authors.lastname: Stabouli
authors.forename: Ioannis
authors.initials: I
authors.lastname: Karafillis
authors.forename: Sofia
authors.initials: S
authors.lastname: Papakatsika
authors.forename: Zoe
authors.initials: Z
authors.lastname: Rizos
authors.forename: Spiros
authors.initials: S
authors.lastname: Miyakis
authors.forename: Sofia
authors.initials: S
authors.lastname: Goulopoulou
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Parati
authors.forename: Peter
authors.initials: P
authors.lastname: Nilsson
mesh_terms: D000293:Adolescent; D000375:Aging / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases / Q000503:physiopathology; D002339:Carotid Arteries / Q000502:physiology; D002940:Circadian Rhythm; D005263:Femoral Artery / Q000502:physiology; D006801:Humans; D011673:Pulsatile Flow / Q000502:physiology; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult