title: Chemo-enzymatic synthesis of a multi-useful chiral building block molecule for the synthesis of medicinal compounds.
abstract: Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a "low-temperature lipase-catalyzed transesterification" carried out at -40 °C.
authors.affiliation: Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, 2-16-1 Tokiwadai, Ube 755-8611, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Nakano
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yagi
authors.forename: Mizuki
authors.initials: M
authors.lastname: Miyahara
authors.forename: Akio
authors.initials: A
authors.lastname: Kaminura
authors.forename: Motoi
authors.initials: M
authors.lastname: Kawatsura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Itoh
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D001426:Bacterial Proteins / Q000378:metabolism*; D001688:Biological Products / Q000138:chemical synthesis*; D002384:Catalysis; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004951:Esterification; D005656:Fungal Proteins / Q000378:metabolism*; D007700:Kinetics; D008049:Lipase / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D010940:Plant Proteins / Q000378:metabolism*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D000438:Alcohols; D001426:Bacterial Proteins; D001688:Biological Products; D005656:Fungal Proteins; D010940:Plant Proteins; D008049:Lipase