title: Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis.
abstract: The immunopathogenesis of respiratory syncytial virus (RSV) and human rhinovirus lower respiratory tract infections in children remains to be defined. We measured nasal wash concentrations of 29 cytokines in infants with RSV or human rhinovirus lower respiratory tract infections. Concentrations of interferon-γ in RSV and innate immunity cytokines in both infections inversely correlated with disease severity.
authors.affiliation: Division of Pediatric Infectious Diseases, UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Carla
authors.initials: C
authors.lastname: García
authors.forename: Alejandra
authors.initials: A
authors.lastname: Soriano-Fallas
authors.forename: Juanita
authors.initials: J
authors.lastname: Lozano
authors.forename: Nora
authors.initials: N
authors.lastname: Leos
authors.forename: Ana M
authors.initials: AM
authors.lastname: Gomez
authors.forename: Octavio
authors.initials: O
authors.lastname: Ramilo
authors.forename: Asuncion
authors.initials: A
authors.lastname: Mejias
mesh_terms: D001990:Bronchiolitis, Viral / Q000276:immunology* / Q000503:physiopathology* / Q000821:virology; D002675:Child, Preschool; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D007223:Infant; D007371:Interferon-gamma / Q000276:immunology / Q000378:metabolism*; D008297:Male; D010850:Picornaviridae Infections / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D012229:Rhinovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D012720:Severity of Illness Index; D013781:Texas
chemical_list: D016207:Cytokines; D007371:Interferon-gamma