title: [A prospective study of propranolol as first-line treatment for problematic infantile hemangioma in China].
abstract: OBJECTIVE
  To prospectively assess the efficacy and safety or propranolol as a first-line treatment for problematic infantile haemangioma in China.
  
  
  METHODS
  From Mar. 2009 to Feb. 2010, 78 patients with problematic infantile hemangioma were included in the prospective study. The characteristics of the tumor, including sex, age, site, complications, were recorded. The response to treatment at 1 week, at 1 month and at the end of treatment was evaluated. The efficacy of treatment was graded as no response, stabilization, or accelerated regression. The indications for treatment, side effects and relapse after treatment were documented. The mean follow-up period was 16.7 months (range, 12.1-23.6 months).
  
  
  RESULTS
  Oral therapy was initiated at mean age of 3.7 months (range, 1.1-9.2 months) as first-line therapy. The mean age at the end of treatment was 11.2 months (range, 5.2-22.3 months). The treatment was lasted for 7.6 months (range, 2. 1-18.3 months). One week after treatment beginning, the hemangioma growth was controlled in all the patients. The accelerated regression was achieved in 88.5% (69/78) of patients after one week of treatment, and 98.7% (77/78) of patients after 1 month of treatment and at the end of treatment. Ulceration was occurred in 14 cases before treatment, which was healed after treatment for 2 months. Minor side effects were happened in 15.4% (12/78) of patients. Rebound growth of lesion was noticed in 35.9% (28/78) of patients.
  
  
  CONCLUSIONS
  Propranolol is effective in the treatment of infantile hemangioma with minor side effect. We suggest it should be used as the first-line treatment.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200011, China.
authors.forename: Yun-bo
authors.initials: YB
authors.lastname: Jin
authors.forename: Xiao-xi
authors.initials: XX
authors.lastname: Lin
authors.forename: Xiao-xiao
authors.initials: XX
authors.lastname: Ye
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Ma
authors.forename: Cheng-hong
authors.initials: CH
authors.lastname: Jiang
authors.forename: Chen
authors.initials: C
authors.lastname: Da
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Chen
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Hu
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D011433:Propranolol / Q000008:administration & dosage* / Q000627:therapeutic use; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D011433:Propranolol