title: Novel techniques in the use of bivalirudin for cardiopulmonary bypass anticoagulation in a child with heparin-induced thrombocytopenia.
abstract: Heparin-induced thrombocytopenia (HIT) occurs in both the pediatric and adult populations after exposure to heparin. Bivalirudin has been used as an alternative to heparin for adults undergoing cardiac surgery and cardiopulmonary bypass, but has only been used minimally in children for this purpose. We report the successful use of bivalirudin for anticoagulation during cardiopulmonary bypass in a small child with HIT, using novel techniques not previously described.
authors.affiliation: Perfusion Services, University of California, Los Angeles, CA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Dragomer
authors.forename: A
authors.initials: A
authors.lastname: Chalfant
authors.forename: R
authors.initials: R
authors.lastname: Biniwale
authors.forename: B
authors.initials: B
authors.lastname: Reemtsen
authors.forename: M
authors.initials: M
authors.lastname: Federman
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D004867:Equipment Design; D006493:Heparin / Q000009:adverse effects*; D006629:Hirudins; D006801:Humans; D007223:Infant; D010446:Peptide Fragments / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; D006493:Heparin; C074619:bivalirudin