title: Cell-based therapy in Chagas disease.
abstract: Chagas disease was first described one century ago, yet the mechanisms underlying chagasic cardiomyopathy remain elusive. Disease progression often leads to heart failure and patients with this infectious cardiomyopathy have a poor prognosis. Treatment options for heart failure due to Chagas disease are not different from standard therapy. Over the past decade, cell-based therapies have emerged as a new alternative in the treatment of this disease, not only because of the possibility of replacing lost vessels and cardiomyocytes but also because these cells could potentially influence the microenvironmental changes that perpetuate the disease. In this chapter, we will review current knowledge on cell-based therapies for the treatment of Chagas disease.
authors.affiliation: Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro and National Cardiology Institute, Rio de Janeiro, RJ, Brazil.
authors.forename: Antonio C Campos
authors.initials: AC
authors.lastname: de Carvalho
authors.forename: Adriana B
authors.initials: AB
authors.lastname: Carvalho
authors.forename: Regina C S
authors.initials: RC
authors.lastname: Goldenberg
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods; D014355:Chagas Disease / Q000150:complications / Q000469:parasitology / Q000628:therapy*; D002986:Clinical Trials as Topic; D018450:Disease Progression; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D051379:Mice; D051381:Rats; D033581:Stem Cell Transplantation / Q000379:methods; D014349:Trypanosoma cruzi / Q000472:pathogenicity*; D018754:Ventricular Dysfunction / Q000469:parasitology / Q000628:therapy*