title: Recent advances in designs, approaches and materials in total knee replacement: literature review and evidence today.
abstract: Ever since Themistocles Gluck described the use of an ivory cup as a tibial hemiarthroplasty in 1894, knee arthoplasty has continued to evolve. Both human ingenuity and intensive clinical research has led to an improved understanding of biomaterials and knee kinematics, resulting in the modern total knee replacement which has enjoyed such a clinical and commercial success. As it increases in popularity, attempts to improve knee arthroplasty have been driven by demands for improved function and implant survival, particularly in younger, more demanding patients. Research continues to see if advances in implant instrumentation, materials and design will translate into improved clinical outcomes and longevity.
authors.affiliation: UCL Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, Middlesex.
authors.forename: James M
authors.initials: JM
authors.lastname: Wong
authors.forename: Wasim S
authors.initials: WS
authors.lastname: Khan
authors.forename: Mukai
authors.initials: M
authors.lastname: Chimutengwende-Gordon
authors.forename: George S E
authors.initials: GS
authors.lastname: Dowd
mesh_terms: D019645:Arthroplasty, Replacement, Knee / Q000295:instrumentation / Q000379:methods*; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008297:Male; D019060:Minimally Invasive Surgical Procedures
chemical_list: D001672:Biocompatible Materials