title: Enantioselective conjugate addition of alkenylboronic acids to indole-appended enones.
abstract: An enantioselective addition of alkenylboronic acids and alkynylboronic esters to unprotected indole-appended enones is reported. This transformation proceeds with high enantioselectivity and high product yields via the use of catalytic amounts of 3,3'-bis(pentafluorophenyl)-BINOL and Mg(Ot-Bu)(2). A range of α-branched indole derivatives are available from the transformation.
authors.affiliation: Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Lundy
authors.forename: Santa
authors.initials: S
authors.lastname: Jansone-Popova
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: May
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001897:Boronic Acids; D004952:Esters; D007211:Indoles; D007659:Ketones