title: Association between hair-induced oronasal inflammation and ulcerative dermatitis in C57BL/6 mice.
abstract: Ulcerative dermatitis (UD) is a genetically linked syndrome that affects the neck, torso, and facial regions of C57BL/6 mice and strains with C57BL/6 background. In this study, 96 mice with skin ulcerations in 3 different regions of the body and 40 control animals without ulcerated lesions were evaluated histologically for the presence of hair-induced inflammation in the oronasal cavity. We found that 73.5% (100 of 136) of the mice had hair-induced periodontitis, glossitis, or rhinitis regardless of the presence or absence of UD. Of those mice with UD, 93.9% had hair-induced oronasal inflammation. The mandibular incisors were the most commonly affected site (64.6%), followed by the maxillary molars (20.8%), maxillary incisors (16.7%), tongue (16.7%), nasal cavity (10.4%), and mandibular molars (7.3%). In addition, oronasal hair-induced inflammation occurred in 25% (10 of 40) of the control mice. Here we show a significant association between UD and hair-induced inflammatory lesions of the oronasal cavities.
authors.affiliation: Division of Laboratory Animal Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA. sandraduarte@mednet.ucla.edu
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Duarte-Vogel
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Lawson
mesh_terms: D000818:Animals; D003872:Dermatitis / Q000150:complications / Q000662:veterinary*; D006197:Hair; D051379:Mice; D008810:Mice, Inbred C57BL; D009055:Mouth / Q000473:pathology*; D009296:Nasal Cavity / Q000473:pathology*; D012376:Rodent Diseases / Q000473:pathology*