title: Diastolic function predicts survival after renal revascularization.
abstract: OBJECTIVE
  The purpose of this study was to define the relationship between left ventricular diastolic function and survival after renal revascularization.
  
  
  METHODS
  Seventy-six adult patients (49 women, 27 men; mean age: 63 ± 13 years) with preoperative echocardiography who underwent renal revascularization for atherosclerotic disease were identified. Diastolic function was estimated from the early diastolic transmitral flow velocity (E), the atrial transmitral flow velocity (A), and the mitral annular tissue doppler velocity (e'). Patients were divided into two groups of diastolic dysfunction as either none/mild (E/A ≤ 0.75, E/e' <10) or moderate/severe (E/A >0.75, E/e' ≥ 10). Perioperative and follow-up mortality were determined from a prospective vascular database and the National Death Index. Descriptive statistics were calculated and postoperative survival was estimated by product-limit methods. Associations between preoperative factors, perioperative factors, and follow-up survival were examined using proportional hazards regression models. A forward stepwise variable selection procedure was used to select a "best" model to predict follow-up survival.
  
  
  RESULTS
  Seventy-six patients were followed for an average of 41.9 months after renal revascularization. Within this group, 47 of 76 patients (61.8%) were identified as having moderate or severe diastolic dysfunction. Diastolic dysfunction had no apparent association with abnormal systolic function. The mean ejection fraction for those with moderate/severe diastolic dysfunction was 57.7% ± 11.5%. When comparing the moderate/severe and none/mild groupings of diastolic dysfunction, there was a significant difference in left ventricular mass index (151.9 ± 48.9 vs 125.3 ± 31.7; P = .0087). There were five deaths in the perioperative period and 20 deaths on follow-up. Among perioperative survivors, hypertension was cured or improved in 82% of the none/mild group and 53% of the moderate/severe group (P = .012). In multivariable analysis, none/mild diastolic dysfunction was significantly and independently associated with an improvement in blood pressure after revascularization (odds ratio [OR], 6.2; 95% confidence interval [CI], 1.4-28.6; P = .018). Ejection fraction was not associated with survival. After forward variable selection, moderate/severe diastolic dysfunction (hazard ratio [HR], 5.8; 95% CI 1.4-25; P = .018) was the only variable to demonstrate a significant and independent association with follow-up survival.
  
  
  CONCLUSIONS
  Diastolic dysfunction, but not systolic dysfunction, was frequent in patients with renovascular disease. Blood pressure response and follow-up survival after renal revascularization demonstrated significant and independent associations with diastolic function. Consideration of diastolic function should be included in the management of patients with atherosclerotic renovascular disease.
authors.affiliation: Department of Vascular and Endovascular Surgery, Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157, USA.
authors.forename: Racheed J
authors.initials: RJ
authors.lastname: Ghanami
authors.forename: Hamza
authors.initials: H
authors.lastname: Rana
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Craven
authors.forename: John
authors.initials: J
authors.lastname: Hoyle
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Edwards
authors.forename: Kimberley J
authors.initials: KJ
authors.lastname: Hansen
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D015331:Cohort Studies; D003971:Diastole / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012078:Renal Artery Obstruction / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures; D016277:Ventricular Function, Left / Q000502:physiology*