title: A novel macrocyclic lactone with insecticidal bioactivity from Streptomyces microflavus neau3.
abstract: A novel macrocyclic lactone (1) was isolated from the fermentation broth of Streptomycesmicroflavus neau3, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed high acaricidal activity against adult mites (IC(50)=11.1 μg mL(-1)), and nematocidal activity against Caenorhabditis elegans (IC(50)=17.4 μg mL(-1)), especially the acaricidal activity against mite eggs with an IC(50) of 37.1 μg mL(-1), which was relative higher than that of the commercial acaricide and nematocide milbemycins A(3)/A(4).
authors.affiliation: School of Life Science, Northeast Agricultural University, Harbin 150030, China.
authors.forename: Xiang-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Chong-Xi
authors.initials: CX
authors.lastname: Liu
authors.forename: Dian-Liang
authors.initials: DL
authors.lastname: Gong
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Wang
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Yan
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Xiang
mesh_terms: D056810:Acaricides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008925:Mites / Q000187:drug effects*; D008968:Molecular Conformation; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D056810:Acaricides; D000969:Antinematodal Agents; D007306:Insecticides; D007783:Lactones; D047028:Macrocyclic Compounds