title: OPCML gene as a schizophrenia susceptibility locus in Thai population.
abstract: Opioid-binding protein/cell adhesion molecule (OPCML) gene has been recently identified as a susceptibility gene for schizophrenia in Europeans. This study aims to investigate the association between single nucleotide polymorphisms (SNPs) in the OPCML gene and risk of schizophrenia in a Thai population. DNA samples of 115 schizophrenia patients and 173 normal controls were genotyped using high-resolution melting analysis and analyzed by chi-square test of SPSS software. We observed a strong association between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population [P = 0.00036; odds ratio for the minor A allele, 2.11(1.57-2.84)]. The previously discovered SNP associated with schizophrenia in Europeans, rs3016384, also showed significant association with schizophrenia in the Thai population [P = 0.01; odds ratio of the minor T allele, 0.59 (0.44-0.79)]. Therefore, the OPCML gene is considered to be a schizophrenia-susceptible gene in the Thai population.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Sukhumvit 23, Bangkok, 10110, Thailand.
authors.forename: Benjaporn
authors.initials: B
authors.lastname: Panichareon
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakayama
authors.forename: Wanpen
authors.initials: W
authors.lastname: Thurakitwannakarn
authors.forename: Sadahiko
authors.initials: S
authors.lastname: Iwamoto
authors.forename: Wasana
authors.initials: W
authors.lastname: Sukhumsirichart
mesh_terms: D000328:Adult; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000502:physiology; D005006:Ethnicity / Q000235:genetics; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics / Q000502:physiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009691:Nucleic Acid Denaturation; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D013785:Thailand / Q000453:epidemiology
chemical_list: D015815:Cell Adhesion Molecules; D058851:GPI-Linked Proteins; C059785:OPCML protein, human