title: Effect of Unex on ethylene glycol-induced urolithiasis in rats.
abstract: This study was aimed to evaluate the effectiveness of the Unex capsule on albino rats as a preventive agent against the development of kidney stones. The Unex capsule is a marketed product of Unijules Life Sciences, Nagpur, containing the extracts of Boerhaavia diffusa and Tribulus terrestris. Activity of Unex was studied using the ethylene glycol-induced urolithiasis model. Standard drug used was Cystone. Several parameters were used including urinary volume, urine pH, urine analysis, and serum analysis to assess the activity. The results indicated that the administration of Unex to rats with ethylene glycol-induced lithiasis significantly reduced and prevented the growth of urinary stones (P < 0.01). Also, the treatment of lithiasis-induced rats by Unex restored all the elevated biochemical parameters (creatinine, uric acid, and blood urea nitrogen), restored the urine pH to normal, and increased the urine volume significantly (P < 0.01) when compared to the model control drug. This study supports the usage of Unex in urolithiasis and the utility could further be confirmed in other animal models.
authors.affiliation: TIFAC CORE in Green Pharmacy, B. R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India.
authors.forename: Elias Edwin
authors.initials: EE
authors.lastname: Jarald
authors.forename: Pankaj
authors.initials: P
authors.lastname: Kushwah
authors.forename: Sheeja
authors.initials: S
authors.lastname: Edwin
authors.forename: Suhail
authors.initials: S
authors.lastname: Asghar
authors.forename: Showkat Ahmad
authors.initials: SA
authors.lastname: Patni