title: [Study of the function and mechanism of interleukin cytokines in acute pancreatitis rats].
abstract: OBJECTIVE
  To explore the molecular mechanism of interleukin cytokines IL-6, IL-17, IL-23, IL-23R in the onset of acute pancreatitis in rats pancreatitis models.
  
  
  METHODS
  Thirty six SD rats were randomized into 3 groups: control group, model group, and intervention group (n = 12). The rats in model group and intervention group were induced by intraperitoneal injection of 1-arginine, and those in intervention group were treated by tail intravenous administration of drugs at the same time. Then the rats were sacrified at 3rd, 6th, and 12th h. after the modeling. The levels of IL-6 ,IL-17, IL-23, IL-23R in blood, pancreas, lung and kidney were checked by ELISA.
  
  
  RESULTS
  The IL-6 levels of serum, pancreas, lung and kidney in AP Model group were obviously higher than those in the control group and intervention group. This trend increased with time. Similarly, the levels of IL-17 and IL-23 in AP group were obviously higher than those in the control group and intervention group. Compared with the control and intervention group, AP group showed higher IL-23R levels in serum, pancreas, but lower IL-23R levels in lung and kidney.
  
  
  CONCLUSIONS
  IL-23 is a mediator involved in the formation of IL-17 and IL-6, they all can promote acute pancreatitis.
authors.affiliation: Hepatobiliary and Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Hu
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Lu
authors.forename: Zhao-Da
authors.initials: ZD
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000818:Animals; D020381:Interleukin-17 / Q000097:blood / Q000378:metabolism*; D053759:Interleukin-23 / Q000097:blood / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism*; D008297:Male; D010195:Pancreatitis / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D018123:Receptors, Interleukin / Q000097:blood / Q000378:metabolism
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23; D015850:Interleukin-6; D018123:Receptors, Interleukin