title: Sinus augmentation in two patients with severe posterior maxillary height atrophy using tissue-engineered bone derived from autologous bone cells: a case report.
abstract: Implant placement in the edentulous maxilla often represents a clinical challenge because of insufficient bone height after crestal bone resorption and maxillary sinus pneumatization. In this study, tissue engineering techniques were used to increase bone height in the posterior maxilla before implant placement. Periosteal biopsies were harvested, and osteoblast precursor cells were isolated and cultured on three-dimensional fleeces (nonwoven polyglactin-910 fibers connected by poly-p-dioxanon bonding sites) in vitro. Tissue-engineered bone chips were implanted into the sinus cavity using a lateral window approach. Four months post-sinus augmentation, implants were placed and subsequently restored. During a 12-month follow-up period, no implant failure was observed.
authors.affiliation: Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University College of Dental Medicine, New York, New York, USA.
authors.forename: Luigi
authors.initials: L
authors.lastname: Montesani
authors.forename: Ulrike
authors.initials: U
authors.lastname: Schulze-Späte
authors.forename: Serge
authors.initials: S
authors.lastname: Dibart
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery; D001284:Atrophy; D001672:Biocompatible Materials / Q000737:chemistry; D018786:Bone Substitutes / Q000627:therapeutic use; D018929:Cell Culture Techniques; D003094:Collagen; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D004146:Dioxanes / Q000737:chemistry; D005500:Follow-Up Studies; D006801:Humans; D007575:Jaw, Edentulous / Q000601:surgery; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery*; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D010006:Osteoblasts / Q000637:transplantation*; D010521:Periosteum / Q000166:cytology; D011098:Polyglactin 910 / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D059546:Sinus Floor Augmentation / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry; D020858:Tissue and Organ Harvesting / Q000379:methods; D014182:Transplantation, Autologous
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D015921:Dental Implants; D004146:Dioxanes; D008567:Membranes, Artificial; D008903:Minerals; D011108:Polymers; C079733:poly-4-dioxan-2-one; D011098:Polyglactin 910; D003094:Collagen