title: A novel preparation method for camptothecin (CPT) loaded folic acid conjugated dextran tumor-targeted nanoparticles.
abstract: In this study, folic-dextran-camptothecin (Fa-DEX-CPT) tumor-targeted nanoparticles were produced with a supercritical antisolvent (SAS) technique by using dimethyl sulfoxide (DMSO) as a solvent and carbon dioxide as an antisolvent. A factorial design was used to reveal the effect of various process parameters on the mean particle size (MPS) and morphology of the particles formed. Under the optimum operation conditions, Fa-DEX-CPT nanoparticles with a MPS of 182.21 nm were obtained. Drug encapsulation efficiency and loading efficiency were 62.13% and 36.12%, respectively. It was found that the concentrations of the camptothecin (CPT) and dextran solution had a major influence upon morphology and shape of the final product. In addition, the samples were characterized by Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) with the purpose of developing a suitable targeted drug delivery system for cancer chemotherapy.
authors.affiliation: Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin 150040, China; E-Mails: wangdan639@126.com (D.W.); 644677614@qq.com (R.J.); 835608075@qq.com (Q.Z.); 156828568@qq.com (D.Z.); 724506183@qq.com (Y.L.); zubaishi@163.com (B.Z.); zhiqiangshun@163.com (Z.S.).
authors.forename: Yuangang
authors.initials: Y
authors.lastname: Zu
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Zhao
authors.forename: Ru
authors.initials: R
authors.lastname: Jiang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhao
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Baishi
authors.initials: B
authors.lastname: Zu
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002166:Camptothecin / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003911:Dextrans / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D005492:Folic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003911:Dextrans; D004337:Drug Carriers; D002245:Carbon Dioxide; D005492:Folic Acid; D002166:Camptothecin; D004121:Dimethyl Sulfoxide