title: Innate and adaptive antifungal immune responses: partners on an equal footing.
abstract: Adaptive immunity has long been regarded as the major player in protection against most fungal infections. Mounting evidence suggest however, that both innate and adaptive responses intricately collaborate to produce effective antifungal protection. Dendritic cells (DCs) play an important role in initiating and orchestrating antifungal immunity; neutrophils, macrophages and other phagocytes also participate in recognising and eliminating fungal pathogens. Adaptive immunity provides a wide range of effector and regulatory responses against fungal infections. Th1 responses protect against most forms of mycoses but they associate with significant inflammation and limited pathogen persistence. By contrast, Th2 responses enhance persistence of and tolerance to fungal infections thus permitting the generation of long-lasting immunological memory. Although the role of Th17 cytokines in fungal immunity is not fully understood, they can enhance proinflammatory or anti-inflammatory responses or play a regulatory role in fungal immunity all depending on the pathogen, site/phase of infection and host immunostatus. T regulatory cells balance the activities of various Th cell subsets thereby permitting inflammation and protection on the one hand and allowing for tolerance and memory on the other. Here, recent developments in fungal immunity research are reviewed as means of tracing the emergence of a refined paradigm where innate and adaptive responses are viewed in the same light.
authors.affiliation: Research and Development Unit, JMS Medicals, Zarqa, Jordan. taqiwmohanad@yahoo.com
authors.forename: Mawieh
authors.initials: M
authors.lastname: Hamad
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D005658:Fungi / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance; D009181:Mycoses / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D016207:Cytokines