title: Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp. and their promoting activities of innate immune responses.
abstract: Innate immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as an innate immune promoter from the fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-α-stimulated production of IL-8 in human umbilical vein endothelial cells.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan. hal@mail.pharm.tohoku.ac.jp
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Kikuchi
authors.forename: Masato
authors.initials: M
authors.lastname: Isobe
authors.forename: Mizuki
authors.initials: M
authors.lastname: Sekiya
authors.forename: Yuko
authors.initials: Y
authors.lastname: Abe
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hoshikawa
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ueda
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Kurata
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Katou
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Oshima
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D019281:Dimerization; D004330:Drosophila / Q000276:immunology; D042783:Endothelial Cells / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000276:immunology* / Q000302:isolation & purification* / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000737:chemistry* / Q000276:immunology; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D016207:Cytokines; D007166:Immunosuppressive Agents