title: Citrus bergamia juice: phytochemical and technological studies.
abstract: Fresh juice from bergamot (Citrus bergamia Risso) has been studied to evaluate the polyphenolic composition by HPLC-DAD analysis and total polyphenols content by UV method. The main constituent, Naringin, has been selected as analytical and biological marker of the juice. Juice has been loaded onto maltodextrin matrix by spray-drying. The produced maltodextrin/juice powder (BMP) showed neither significant change in total polyphenols content nor decrease in antioxidant properties with respect to fresh juice. Moreover, BMP displayed high in vitro dissolution rate of the bioactive constituents in water and in simulated biological fluids. BMP appears as promising functional raw material for food, nutraceutical and pharmaceutical products. With this aim, a formulation study to develop tablets (BMT) for oral administration has been also performed. The produced solid oral dosage form preserved high polyphenols content, showed complete disaggregation in few minutes and satisfying dissolution rate of the bioactive constituents in simulated biological fluids.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Picerno
authors.forename: Francesca
authors.initials: F
authors.lastname: Sansone
authors.forename: Teresa
authors.initials: T
authors.lastname: Mencherini
authors.forename: Lucia
authors.initials: L
authors.lastname: Prota
authors.forename: Rita Patrizia
authors.initials: RP
authors.lastname: Aquino
authors.forename: Luca
authors.initials: L
authors.lastname: Rastrelli
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Lauro
mesh_terms: D000975:Antioxidants / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D001713:Biphenyl Compounds / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002957:Citrus / Q000737:chemistry*; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit / Q000737:chemistry*; D010636:Phenols / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D010851:Picrates / Q000737:chemistry; D059808:Polyphenols; D011134:Polysaccharides / Q000737:chemistry; D013607:Tablets / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D010636:Phenols; D010851:Picrates; D059808:Polyphenols; D011134:Polysaccharides; D013607:Tablets; C008315:maltodextrin; C004931:1,1-diphenyl-2-picrylhydrazyl