title: Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence.
abstract: We report here the identification and characterization of a previously uncharacterized, two-component response regulator gene (orf19.5843) from Candida albicans. Because of its apparent functions in stress adaptation, we have named this gene SRR1 (stress response regulator 1). Disruption of SRR1 causes defects in hyphal development, reduced resistance to stress, and severe virulence attenuation in the mouse model of disseminated candidiasis.
authors.affiliation: Public Health Research Institute and Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 225 Warren Street, Newark, NJ 07078, USA.
authors.forename: Chirayu
authors.initials: C
authors.lastname: Desai
authors.forename: John
authors.initials: J
authors.lastname: Mavrianos
authors.forename: Neeraj
authors.initials: N
authors.lastname: Chauhan
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000235:genetics / Q000254:growth & development* / Q000472:pathogenicity* / Q000502:physiology; D002177:Candidiasis / Q000382:microbiology*; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D005809:Genes, Regulator; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D017434:Protein Structure, Tertiary; D013312:Stress, Physiological; D014774:Virulence
chemical_list: D005656:Fungal Proteins