title: Cancer-targeted optical imaging with fluorescent zinc oxide nanowires.
abstract: Herein we demonstrate that intrinsically fluorescent zinc oxide (ZnO) nanowires (NWs) can be adopted for molecularly targeted imaging of cancer cells, after they are functionalized to render water solubility, biocompatibility, and low cellular toxicity. Optical imaging of integrin α(v)β(3) on U87MG human glioblastoma cells was achieved with RGD peptide-conjugated green fluorescent ZnO NWs, which opened up new avenues of research for investigating ZnO NW-based agents in tumor vasculature-targeted molecular imaging and drug delivery.
authors.affiliation: Department of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
authors.forename: Hao
authors.initials: H
authors.lastname: Hong
authors.forename: Jian
authors.initials: J
authors.lastname: Shi
authors.forename: Yunan
authors.initials: Y
authors.lastname: Yang
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Engle
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Nickles
authors.forename: Xudong
authors.initials: X
authors.lastname: Wang
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D045744:Cell Line, Tumor; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning / Q000379:methods; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008856:Microscopy, Fluorescence / Q000379:methods*; D008956:Models, Chemical; D053770:Nanowires / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009842:Oligopeptides / Q000737:chemistry; D055095:Optics and Photonics; D012995:Solubility; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D039302:Integrin alphaVbeta3; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; D015034:Zinc Oxide