title: Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.
abstract: The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment.
authors.affiliation: Laboratory of Genetics (LOG-G), The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Marchetto
authors.forename: Kristen J
authors.initials: KJ
authors.lastname: Brennand
authors.forename: Leah F
authors.initials: LF
authors.lastname: Boyer
authors.forename: Fred H
authors.initials: FH
authors.lastname: Gage
mesh_terms: D000818:Animals; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D008954:Models, Biological; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism