title: Polyphenols in alcoholic beverages activating constitutive androstane receptor CAR.
abstract: The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins. We examined alcoholic beverage phytochemicals for their ability to activate CAR. HepG2 cells were transfected with CAR expression vector and its reporter gene, and then treated with trans-resveratrol, ellagic acid, β-caryophyllene, myrcene, and xanthohumol. A luciferase assay revealed that ellagic acid and trans-resveratrol activated both human and mouse CAR. Since CAR regulates many genes involved in energy metabolism, the possibility exists that these polyphenols would reduce the risk of certain alcohol-induced metabolic disorders with the help of CAR.
authors.affiliation: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Ruiqing
authors.initials: R
authors.lastname: Yao
authors.forename: Akihito
authors.initials: A
authors.lastname: Yasuoka
authors.forename: Asuka
authors.initials: A
authors.lastname: Kamei
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Rogi
authors.forename: Norifumi
authors.initials: N
authors.lastname: Taieishi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tsuruoka
authors.forename: Yoshionobu
authors.initials: Y
authors.lastname: Kiso
authors.forename: Takumi
authors.initials: T
authors.lastname: Misaka
authors.forename: Keiko
authors.initials: K
authors.lastname: Abe
mesh_terms: D000080462:Acyclic Monoterpenes; D000428:Alcohol Drinking / Q000378:metabolism*; D000434:Alcoholic Beverages / Q000032:analysis*; D000475:Alkenes / Q000494:pharmacology; D000818:Animals; D000090702:Constitutive Androstane Receptor; D004610:Ellagic Acid / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology; D017930:Genes, Reporter; D056945:Hep G2 Cells; D006801:Humans; D008156:Luciferases / Q000032:analysis; D051379:Mice; D039821:Monoterpenes / Q000494:pharmacology; D010957:Plasmids; D000081223:Polycyclic Sesquiterpenes; D059808:Polyphenols / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D000077185:Resveratrol; D040242:Risk Reduction Behavior; D012717:Sesquiterpenes / Q000494:pharmacology; D013267:Stilbenes / Q000494:pharmacology; D014162:Transfection
chemical_list: D000080462:Acyclic Monoterpenes; D000475:Alkenes; D000090702:Constitutive Androstane Receptor; D005419:Flavonoids; D039821:Monoterpenes; D000081223:Polycyclic Sesquiterpenes; D059808:Polyphenols; D011427:Propiophenones; D018160:Receptors, Cytoplasmic and Nuclear; D012717:Sesquiterpenes; D013267:Stilbenes; D004610:Ellagic Acid; C509595:myrcene; C024714:caryophyllene; D008156:Luciferases; D000077185:Resveratrol; C104536:xanthohumol