title: Building the posterior lateral line system in zebrafish.
abstract: The posterior lateral line (pLL) in zebrafish has emerged as an excellent system to study how a sensory organ system develops. Here we review recent studies that illustrate how interactions between multiple signaling pathways coordinate cell fate,morphogenesis, and collective migration of cells in the posterior lateral line primordium. These studies also illustrate how the pLL system is contributing much more broadly to our understanding of mechanisms operating during the growth, regeneration, and self-organization of other organ systems during development and disease.
authors.affiliation: The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. chitnisa@mail.nih.gov
authors.forename: Ajay B
authors.initials: AB
authors.lastname: Chitnis
authors.forename: Damian Dalle
authors.initials: DD
authors.lastname: Nogare
authors.forename: Miho
authors.initials: M
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D053403:Lateral Line System / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism; D009024:Morphogenesis / Q000502:physiology; D019707:Receptors, Chemokine / Q000096:biosynthesis; D015398:Signal Transduction / Q000502:physiology; D015027:Zebrafish / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism; D029961:Zebrafish Proteins / Q000096:biosynthesis
chemical_list: D019707:Receptors, Chemokine; D029961:Zebrafish Proteins