title: Long-term success of intravitreal bevacizumab for choroidal neovascularization associated with choroidal osteoma.
abstract: OBJECTIVE
  To describe a case of choroidal osteoma with choroidal neovascularization (CNV) that was successfully treated with two intravitreal injections of bevacizumab (IVB).
  
  
  METHODS
  Case report on a 12-year-old Japanese girl who presented with a sudden decrease in vision in her left eye. At the first visit, 2 days after the onset of her symptoms, her visual acuity (VA) in her left eye was 0.2. Ophthalmoscopy showed a hemorrhage of 5 disc diameters under the retinal pigment epithelium and a serous retinal detachment at the posterior pole of the left eye. These findings were confirmed by optical coherence tomography. Fluorescein angiography (FA) and indocyanine green angiography (ICGA) showed several points of leakage around the fovea, which suggested a CNV. From these findings, the patient was diagnosed with choroidal osteoma with a CNV. The submacular hemorrhage was from the CNV associated with the choroidal osteoma. We treated her with two injections of 1.25 mg/0.05 mL IVB with a 4-month interval.
  
  
  RESULTS
  The patient's VA in her left eye improved to 0.7, and this vision was maintained for 4 years. The CNV disappeared in the FA and ICGA images and no recurrence was observed after 4 years.
  
  
  CONCLUSIONS
  Our findings indicate that IVB is effective in resolving CNV in eyes with an osteoma and prevents a decrease of vision in eyes with a choroidal osteoma with a CNV.
authors.affiliation: Department of Ophthalmology, National Hospital Organization, Chiba Medical Center, Chiba, Japan;
authors.forename: Mariko
authors.initials: M
authors.lastname: Kubota-Taniai
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Oshitari
authors.forename: Maya
authors.initials: M
authors.lastname: Handa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Baba
authors.forename: Jiro
authors.initials: J
authors.lastname: Yotsukura
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto