title: Adaptation as a genome-wide autoregulatory principle in the stress response of yeast.
abstract: The gene expression response of yeast to various types of stresses/perturbations shows a common functional and dynamical pattern for the vast majority of genes, characterised by a quick transient peak (affecting primarily short genes) followed by a return to the pre-stimulus level. Kinetically, this process of adaptation following the transient excursion can be modelled using a genome-wide autoregulatory mechanism by means of which yeast aims at maintaining a preferential concentration in its mRNA levels. The resulting feedback system explains well the different time constants observable in the transient response, while being in agreement with all the known experimental dynamical features. For example, it suggests that a very rapid transient can be induced also by a slowly varying concentration of the gene products.
authors.affiliation: SISSA International School for Advanced Studies, Trieste, Italy.
authors.forename: G
authors.initials: G
authors.lastname: De Palo
authors.forename: F
authors.initials: F
authors.lastname: Eduati
authors.forename: M
authors.initials: M
authors.lastname: Zampieri
authors.forename: B
authors.initials: B
authors.lastname: Di Camillo
authors.forename: G
authors.initials: G
authors.lastname: Toffolo
authors.forename: C
authors.initials: C
authors.lastname: Altafini
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D003198:Computer Simulation; D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D016678:Genome / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D008954:Models, Biological; D020543:Proteome / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D020543:Proteome; D029701:Saccharomyces cerevisiae Proteins