title: High relaxivity and stability of a hydroxyquinolinate-based tripodal monoaquagadolinium complex for use as a bimodal MRI/optical imaging agent.
abstract: An octadentate ligand based on triazacyclononane and 8-hydroxyquinolinate/phenolate binding units leads to very soluble, highly stable lanthanide complexes. The monoaquagadolinium complex shows a high relaxivity as a result of the unusually long rotational correlation time, fast water exchange rate, and slow electronic relaxation. The ligand also acts as sensitizer of the near-IR luminescence emission of the Yb and Nd ions. It appears as an excellent candidate for use as a bimodal imaging agent.
authors.affiliation: Laboratoire de Reconnaissance Ionique et Chimie de Coordination, SCIB, UMR-E 3 CEA/UJF-Grenoble 1, INAC, Grenoble, F-38054, France.
authors.forename: Gaylord
authors.initials: G
authors.lastname: Tallec
authors.forename: Pascal H
authors.initials: PH
authors.lastname: Fries
authors.forename: Daniel
authors.initials: D
authors.lastname: Imbert
authors.forename: Marinella
authors.initials: M
authors.lastname: Mazzanti
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D062385:Hydroxybenzoates / Q000737:chemistry; D008024:Ligands; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D015394:Molecular Structure; D009354:Neodymium / Q000032:analysis; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011805:Quinolinic Acids / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared; D015018:Ytterbium / Q000032:analysis
chemical_list: D003287:Contrast Media; D062385:Hydroxybenzoates; D008024:Ligands; D009942:Organometallic Compounds; D011805:Quinolinic Acids; D009354:Neodymium; D005682:Gadolinium; C017616:phenolic acid; D015018:Ytterbium