title: New insights into asthma pathogenesis and treatment.
abstract: Although national asthma guidelines help organize standards for asthma care, current asthma management is still primarily symptom based. Recent reports provide insights on how to improve asthma management through steps to better understand the natural history of asthma, individualize asthma care, reduce asthma exacerbations, manage inner city asthma, and some potential new ways to use available medications to improve asthma control. Despite many significant gains in managing asthma, we must now find improved strategies to prevent asthma exacerbations, alter the natural history of the disease, and to reduce health disparities in asthma care. Perhaps new directions in personalized medicine including a systems biology approach, along with improved health care access and communication will lead to better methods to alleviate the burden of asthma. This review will discuss the benefits and limitations of the current approach to asthma management, new studies that could impact new directions in asthma management, and new insights related to mechanisms of asthma and allergic airways inflammation that could eventually lead to improved asthma control.
authors.affiliation: Helen Wohlberg & Herman Lambert Chair in Pharmacokinetics, Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado School of Medicine, Denver, CO 80206, USA. szeflers@njhealth.org
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Szefler
authors.forename: Azzeddine
authors.initials: A
authors.lastname: Dakhama
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000628:therapy*; D004198:Disease Susceptibility; D006801:Humans; D057285:Precision Medicine