title: Pre-surgical mood predicts memory decline after anterior temporal lobe resection for epilepsy.
abstract: This study examined pre-surgical depressed mood as a predictor of post-surgical memory change in adults who underwent temporal lobe resections (TLRs; n = 211). Patients completed the Wechsler Memory Scale-III and Beck Depression Inventory-Second Edition (BDI-II) before and after TLR (left = 110, right = 101) and were divided into two groups (clinically elevated depressive symptoms or not depressed) based on BDI-II score. Left-TLR patients with poorer pre-surgical mood had greater verbal memory declines after surgery compared with nondepressed left- or right-TLR patients and right-TLR patients with poor mood. Further, pre-surgical BDI-II score demonstrated incremental validity in predicting post-surgical memory change in left-TLR patients beyond pre-surgical memory scores. Differences in seizure outcome and post-surgical mood change could not account for memory decline. Results suggest that elevated pre-surgical depressive symptomatology is a risk factor for post-surgical memory decline and indicate that mood should be considered when advising patients about cognitive risks associated with temporal lobectomy. Results are discussed in terms of poor pre-surgical mood as an indicator of reduced cognitive reserve.
authors.affiliation: Cleveland Clinic Epilepsy Center, Neurological Institute, OH 44195, USA. buschr@ccf.org
authors.forename: Robyn M
authors.initials: RM
authors.lastname: Busch
authors.forename: Mario F
authors.initials: MF
authors.lastname: Dulay
authors.forename: Kevin H
authors.initials: KH
authors.lastname: Kim
authors.forename: Jessica S
authors.initials: JS
authors.lastname: Chapin
authors.forename: Lara
authors.initials: L
authors.lastname: Jehi
authors.forename: Colleen C
authors.initials: CC
authors.lastname: Kalman
authors.forename: Richard I
authors.initials: RI
authors.lastname: Naugle
authors.forename: Imad M
authors.initials: IM
authors.lastname: Najm
mesh_terms: D000293:Adolescent; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000150:complications*; D000368:Aged; D000704:Analysis of Variance; D038481:Anterior Temporal Lobectomy / Q000009:adverse effects / Q000379:methods / Q000523:psychology*; D004833:Epilepsy, Temporal Lobe / Q000523:psychology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000523:psychology; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D011300:Preoperative Care / Q000523:psychology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult