title: Histopathological, immunohistochemical and ultrastructural studies of a renal mesenchymal tumor in a young beagle dog.
abstract: A 15-month-old male beagle dog used in a toxicity study had a primary renal mesenchymal tumor. Macroscopically, the tumor was a gray-white mass which was found in the right kidney, and extended from the capsule to a position slightly compressing the medulla. Microscopically, most of the tumor cells showed a myxoid pattern, in which the matrix was positive for alcian blue staining. In the other parts of the tumor, a fascicular and wavy pattern was observed, and the matrix was full of collagen fibrils. Immunohistochemically, tumor cells were positive for vimentin and fibronectin, and negative for cytokeratin, desmin, α-smooth muscle actin, Von Willebrand factor, cyclooxigenase-2 and myelin basic protein. As a result, we diagnosed this case to be a renal mesenchymal tumor. Based on the microscopic findings, interstitial characteristics and immunohistochemical features, the present case was classified as a congenital mesoblastic tumor.
authors.affiliation: Toxicological Research Laboratories, Kyowa Hakko Kirin, Co., Ltd., Shizuoka, Japan. yui.manabe@kyowa-kirin.co.jp
authors.forename: Yui
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Katsumi
authors.initials: K
authors.lastname: Takaba
authors.forename: Itaru
authors.initials: I
authors.lastname: Yamaguchi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Myoujou
authors.forename: Naoya
authors.initials: N
authors.lastname: Kimoto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Ikegami
authors.forename: Koji
authors.initials: K
authors.lastname: Saeki
authors.forename: Minami
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Chie
authors.initials: C
authors.lastname: Takada
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D007680:Kidney Neoplasms / Q000151:congenital / Q000473:pathology / Q000662:veterinary*; D008297:Male; D018201:Nephroma, Mesoblastic / Q000473:pathology / Q000662:veterinary*