title: Periodic multidrug therapy in a within-host virus model.
abstract: Floquet theory and perturbation techniques are used to analyze a classical within-host virus model with periodic drug treatment. Both single and multidrug treatment strategies are investigated. Specifically, the effects of both RT-inhibitors and P-inhibitors on the stability of the infection-free steady state are studied. It is found that when both classes of drugs have periodic drug efficacy functions, then shifting the phase of these functions can critically affect the stability of the infection-free steady state. A numerical study is conducted to illustrate the theoretical results and provide additional insights.
authors.affiliation: Department of Mathematics, University of Florida, Gainesville, FL 32611-8105, USA. cambro@ufl.edu
authors.forename: Cameron J
authors.initials: CJ
authors.lastname: Browne
authors.forename: Sergei S
authors.initials: SS
authors.lastname: Pilyugin
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D003198:Computer Simulation; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors