title: Effects of cysteinyl-leukotriene receptors' antagonism by montelukast on lung mechanics and olfactory system histology in healthy mice.
abstract: BACKGROUND
  At variance with steroid administration, the possible effects of leukotrienes inhibition on basal respiratory mechanics and olfactory system function are still unclear.
  
  
  OBJECTIVE
  To investigate if interference with the leukotrienes activity may influence basal lung mechanics in healthy mammals, as well as the olfactory system.
  
  
  METHODS
  We measured lung mechanics by the end-inflation occlusion method in control and in montelukast i.p. treated anaesthetised healthy mice (10 mg/kg/die for a week). A study of olfactory system histology was also conducted.
  
  
  RESULTS
  Elastance and resistive properties of the lung were not affected by montelukast, while a significant increment of lung hysteresis was observed. The analysis of olfactory system histology revealed no significant effects of montelukast compared to controls.
  
  
  CONCLUSIONS
  Leukotrienes' antagonism does not affect respiratory mechanics in basal conditions, except for a hysteresis increment, which might counteract the increase in expiratory flow in asthmatic subjects assuming montelukast.
authors.affiliation: Department of Human Anatomy and Physiology, Section of Physiology, University of Padova, Padova, Italy. alessandro.rubini@unipd.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rubini
authors.forename: Michela
authors.initials: M
authors.lastname: Bondì
authors.forename: Carla
authors.initials: C
authors.lastname: Mucignat-Caretta
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003521:Cyclopropanes; D007274:Injections, Intraperitoneal; D020024:Leukotriene Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D008168:Lung / Q000502:physiology*; D008297:Male; D051379:Mice; D009831:Olfactory Mucosa / Q000166:cytology / Q000187:drug effects*; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*; D018077:Receptors, Leukotriene / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013440:Sulfides
chemical_list: D000085:Acetates; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D018077:Receptors, Leukotriene; D013440:Sulfides; C093875:montelukast