title: Disease embryo development network reveals the relationship between disease genes and embryo development genes.
abstract: A basic problem for contemporary biology and medicine is exploring the correlation between human disease and underlying cellular mechanisms. For a long time, several efforts were made to reveal the similarity between embryo development and disease process, but few from the system level. In this article, we used the human protein-protein interactions (PPIs), disease genes with their classifications and embryo development genes and reconstructed a human disease-embryo development network to investigate the relationship between disease genes and embryo development genes. We found that disease genes and embryo development genes are prone to connect with each other. Furthermore, diseases can be categorized into three groups according to the closeness with embryo development in gene overlapping, interacting pattern in PPI network and co-regulated by microRNAs or transcription factors. Embryo development high-related disease genes show their closeness with embryo development at least in three biological levels. But it is not for embryo development medium-related disease genes and embryo development low-related disease genes. We also found that embryo development high-related disease genes are more central than other disease genes in the human PPI network. In addition, the results show that embryo development high-related disease genes tend to be essential genes compared with other diseases' genes. This network-based approach could provide evidence for the intricate correlation between disease process and embryo development, and help to uncover potential mechanisms of human complex diseases.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
authors.forename: Binsheng
authors.initials: B
authors.lastname: Gong
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhang
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.forename: Hongchao
authors.initials: H
authors.lastname: Lv
authors.forename: Yi
authors.initials: Y
authors.lastname: Zou
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Shaoqi
authors.initials: S
authors.lastname: Rao
mesh_terms: D004194:Disease / Q000235:genetics*; D047108:Embryonic Development / Q000235:genetics*; D053263:Gene Regulatory Networks / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011485:Protein Binding / Q000235:genetics; D025941:Protein Interaction Mapping / Q000379:methods