title: Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6.
abstract: Theiler's murine encephalomyelitis virus infection of C57BL/6 mice results in acute behavioral seizures in 50% of the mice. Treatment of infected mice with minocycline or infection of interleukin (IL)-6-deficient chimeric mice results in a significant decrease in the number of mice developing seizures. However, in those mice that do develop seizures, the pathological changes (neuronal cell loss, inflammation [perivascular cuffing, gliosis, activated microglia/macrophages]), and the numbers of virus infected cells in minocycline-treated or IL-6-deficient chimeric mice are very similar. Therefore, once seizures develop, the pathological changes are consistent regardless of the treatment or genetic background.
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Libbey
authors.forename: Nikki J
authors.initials: NJ
authors.lastname: Kennett
authors.forename: Karen S
authors.initials: KS
authors.lastname: Wilcox
authors.forename: H Steve
authors.initials: HS
authors.lastname: White
authors.forename: Robert S
authors.initials: RS
authors.lastname: Fujinami
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism; D018188:Cardiovirus Infections / Q000150:complications*; D004195:Disease Models, Animal; D005911:Gliosis / Q000473:pathology; D015850:Interleukin-6 / Q000172:deficiency*; D008264:Macrophages / Q000473:pathology / Q000821:virology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017628:Microglia / Q000473:pathology / Q000821:virology; D008911:Minocycline / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000473:pathology* / Q000821:virology; D017945:Theilovirus / Q000472:pathogenicity*
chemical_list: D015850:Interleukin-6; D008911:Minocycline