title: Invasive cutaneous squamous cell carcinoma presenting as a nonhealing radiation wound: a case report.
abstract: Cutaneous squamous cell carcinoma is the second most common form of skin cancer and accounts for 20% of cutaneous malignancies. We report the case of a patient who presented with a complaint of nonhealing wounds following radiation therapy for the treatment of noninvasive squamous cell carcinoma of both lower extremities. Initial biopsies of the wounds were benign. However, a second biopsy performed approximately 2 months later was found to be positive for invasive squamous cell carcinoma. This case uniquely exemplifies that all nonhealing wounds should be viewed with a critical eye for possible malignancy even in the presence of previous negative biopsy. This is especially true for radiation wounds that may be prone to malignant transformation or recurrence.
authors.affiliation: Wound Care Center, St. Barnabas Medical Center, Livingston, NJ 07039, USA. sjlongobardi@gmail.com
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Longobardi
authors.forename: Brian
authors.initials: B
authors.lastname: Sullivan
authors.forename: E Hani
authors.initials: EH
authors.lastname: Mansour
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007871:Leg Ulcer / Q000175:diagnosis* / Q000473:pathology; D035002:Lower Extremity; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D011832:Radiation Injuries / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D014945:Wound Healing / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents