title: Self-assembled antimicrobial and biocompatible copolymer films on titanium.
abstract: Copolymers of 4-vinyl-N-hexylpyridinium bromide and dimethyl(2-methacryloyloxyethyl) phosphonate self-assemble to form ultrathin layers on titanium surfaces that show antimicrobial activity, and biocompatibility. The copolymer layers are characterized by contact angle measurements, ellipsometry and XPS. Antibacterial activity is assessed by investigation of adherence of S. mutans. Biocompatibility is rated based on human gingival fibroblast adhesion and proliferation. By balancing the opposing effects of the chemical composition on biocompatibility and antimicrobial activity, copolymer coatings are fabricated that are able to inhibit the growth of S. mutans on the surface but still show attachment of gingival fibroblasts, and therefore might prevent biofilm formation on implants.
authors.affiliation: Institute for Technical Chemistry, Braunschweig University of Technology, Braunschweig, Germany.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Pfaffenroth
authors.forename: Andreas
authors.initials: A
authors.lastname: Winkel
authors.forename: Wibke
authors.initials: W
authors.lastname: Dempwolf
authors.forename: Lara J
authors.initials: LJ
authors.lastname: Gamble
authors.forename: David G
authors.initials: DG
authors.lastname: Castner
authors.forename: Meike
authors.initials: M
authors.lastname: Stiesch
authors.forename: Henning
authors.initials: H
authors.lastname: Menzel
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D015921:Dental Implants; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005881:Gingiva / Q000166:cytology / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D018625:Microscopy, Atomic Force; D056951:Photoelectron Spectroscopy; D011108:Polymers / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D008689:Methacrylates; D011108:Polymers; D011726:Pyridinium Compounds; D014025:Titanium