title: [History, current state and future perspective of tuberculosis research and clinical medicine].
abstract: Since Robert Koch identified Mycobacterium tuberculosis as causative agent of tuberculosis (TB) in 1882, TB research has developed in various fields, such as bacteriology, immunology, genomic study and genetic susceptibility. These research results have led to the knowledge concerning cellular immunity and the development of biochemical and gene diagnostic approach for M. tuberculosis, interferon-gamma release assay for latent TB infection and epidemiologic study using variable numbers of tandem repeats. After Selman A. Waksman isolated streptomycin, various drugs came to be used. Standard of the TB treatments has been revised several times up to now. Discovery of the novel drugs potential for multidrug-resistant TB is challenged. Close relationships among basic research, clinical medicine and health service are crucial to improving global control of TB.
authors.affiliation: Department of Respiratory Medicine, Kyoto University Hospital.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ito
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
mesh_terms: D005544:Forecasting; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D012106:Research / Q000266:history / Q000639:trends; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy