title: A general and efficient approach to 2H-indazoles and 1H-pyrazoles through copper-catalyzed intramolecular N-N bond formation under mild conditions.
abstract: A new efficient copper-catalyzed intramolecular amination reaction has been developed to readily synthesise a wide variety of multi-substituted 2H-indazole and 1H-pyrazole derivatives from easily accessible starting materials under mild conditions. A highly selective ligand for estrogen receptor β was prepared in three steps by employing this method.
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
authors.forename: Jiantao
authors.initials: J
authors.lastname: Hu
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Cheng
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Yang
authors.forename: Yu
authors.initials: Y
authors.lastname: Rao
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007191:Indazoles / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D007191:Indazoles; D011720:Pyrazoles; C031280:pyrazole; D003300:Copper