title: Synthesis and antioxygenic activities of seabuckthorn flavone-3-ols and analogs.
abstract: A practical synthesis of polyhydroxy- and regiospecifically methylated flavone-3-ols which are components of commercial 'seabuckthorn flavone' has been achieved by modified Algar-Flynn-Oyamada method. Antioxidant activities of seabuckthorn extracts, isolated products and a number of flavone-3-ols have been determined. Structure-activity relationships have been discussed. Amongst the compounds tested, gallic acid, which is also present in seabuckthorn, was found to be the most effective antioxidant and radioprotectant.
authors.affiliation: Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam 690525, Kerala, India.
authors.forename: N
authors.initials: N
authors.lastname: Pandurangan
authors.forename: Chinchu
authors.initials: C
authors.lastname: Bose
authors.forename: A
authors.initials: A
authors.lastname: Banerji
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D060326:Chemistry Techniques, Synthetic; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D047309:Flavones; D010100:Oxygen