title: Strategies and implications for prime-boost vaccination to generate memory CD8 T cells.
abstract: Generating a large population of memory CD8 T cells is an appealing goal for vaccine design against a variety of human diseases. Indeed, experimental models have demonstrated that the overall number of memory CD8 T cells present at the time of infection correlates strongly with the ability to confer host protection against a range of different pathogens. Currently, the most conceivable approach to rapidly generate a large population of memory CD8 T cells is through the use of prime-boost vaccination. In addition, recent experimental findings have uncovered important principles that govern both the rate and magnitude of memory CD8 T cell formation. Thus, this has resulted in novel prime-boost vaccination strategies that could potentially be used in humans to generate protective populations of memory CD8 T cells.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Nolz
authors.forename: John T
authors.initials: JT
authors.lastname: Harty
mesh_terms: D000818:Animals; D015478:Antigens, Heterophile / Q000276:immunology / Q000494:pharmacology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D005822:Genetic Vectors / Q000276:immunology; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D007156:Immunologic Memory / Q000235:genetics / Q000276:immunology; D051379:Mice; D013997:Time Factors; D014611:Vaccination / Q000379:methods*; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology
chemical_list: D015478:Antigens, Heterophile; D014765:Viral Vaccines