title: [Wilson disease. A case report and review of the literature].
abstract: BACKGROUND
  Wilson disease is a problem of cuprum metabolism, with recesive autosomic hereditary transmission and a prevalence of one in 30,000 habitants. The cuprum is deposit in a progressive and irreversible way in the liver and encephalus and it is not liberated with quelant treatment. Neurological manifestations are tremor, disartria, extrapiramidal manifestations or distonia. Ophthalmic exploration shows corneal limb with sign of Kayser-Fleischer.
  
  
  METHODS
  a 15-year-old masculine patient with previous hepatitis outbreak in two times. During the last year he presented distonia, bradicinecious, stiffness and indifference with ictericia. Ophthalmological examination reported Kayser-Fleisher rings. Magnetic resonance of brain showed high dense images in lenticular, pallidus globe and caudate nucleus suggestive of Wilson disease. Ceruloplasmin concentration, cuprum in the liver biopsy confirmed the diagnosis.
  
  
  CONCLUSIONS
  the importance of the case was the hepatic initial manifestations and two years after presented with inexpressive face, and it was considered a psychiatric disease, but the neurological evaluation and the liver biopsy confirmed the diagnosis of Wilson disease.
authors.affiliation: Departamento de Neurología Pediátrica, Hospital General, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Distrito Federal, México. puebla302@hotmail.com
authors.forename: Edith
authors.initials: E
authors.lastname: Alva-Moncayo
authors.forename: María
authors.initials: M
authors.lastname: Castro-Tarín
authors.forename: Adolfo
authors.initials: A
authors.lastname: González-Serrano
mesh_terms: D000293:Adolescent; D006527:Hepatolenticular Degeneration / Q000175:diagnosis*; D006801:Humans; D008297:Male