title: [Synthesis and basic physicochemical properties of 1-[3-(Y-alkoxyphenylcarbamoyloxy)-2-hydroxypropyl]-4-(2-methylphenyl)piperazinium chlorides].
abstract: 1-[3-(Y-Alkoxyphenylcarbamoyloxy)-2-hydroxypropyl]-4-(2-methylphenyl)piperazinium chlorides (labelled as 7a-7d) were prepared within a complex study of the relationships between the chemical structure, physicochemical properties and biological (antiarrhythmic, antihypertensive) activity of dual acting compounds. Chemical structures of basic forms (labelled as 7a2C-7d2C) and appropriate monochlorides (labelled as 7a-7d) were confirmed by 1H-NMR, 13C-NMR, MS and IR spectral and elemental analysis. The estimated physicochemical parameters included the melting point data, solubility profile in various media, purity checking (adsorption thin-layer chromatography), surface activity determination (Traube stalagmometric method), acidobasic characteristics (pKa value determination by alkalimetric titration) as well as the log epsilon values estimation by UV/VIS spectrophotometry. Other experimental values under consideration were lipohydrophilic characteristics using reversed-phase thin-layer chromatography (R(M) readouts) RP-HPLC (log k' data) and the log P(exp) s estimated in octan-1-ol/phosphate buffer medium.
authors.affiliation: Univerzita Komenského Bratislava, Farmaceutická fakulta, Katedra farmaceutickej chémie, Bratislava, Slovenská republika. malik@fpharm.uniba.sk
authors.forename: Ivan
authors.initials: I
authors.lastname: Malík
authors.forename: Eva
authors.initials: E
authors.lastname: Sedlárová
authors.forename: Fils
authors.initials: F
authors.lastname: Andriamainty
authors.forename: Jana
authors.initials: J
authors.lastname: Galisinová
authors.forename: Jozef
authors.initials: J
authors.lastname: Csöllei
authors.forename: Ján
authors.initials: J
authors.lastname: Vanco
mesh_terms: D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D002855:Chromatography, Thin Layer; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
chemical_list: D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D010879:Piperazines