title: Fabrication, characterization, and application of greigite nanoparticles for cancer hyperthermia.
abstract: Greigite is a Fe-S-containing complex having magnetic properties mainly synthesized in the solution. In the present study, greigite was synthesized by a coprecipitation method at different pH's and reaction times. The greigite phase was analyzed by the X-ray diffraction (XRD) method at an optimum pH of 3.0 and reaction time of 10 min, respectively. The magnetization characterization by superconducting quantum interference device (SQUID) revealed that the magnetic saturation was obtained at 16.1538 (emu/g). The inductive heating property of the greigite nanoparticles was carried out by induction heater power cube (IHPC) in an alternating current magnetic field and the results indicated that the heating effect was significant. Transmission electron microscopy (TEM) revealed that the size of the greigite was around 50-100 nm and the edges of nanoparticles have no clear boundary or distinctive morphology. Studies on LDH and WST-I assay revealed low cytotoxicity at greigite concentrations of 1 mg/ml. In vitro experiments suggested that cancerous cells, human lung adenocarcinoma epithelial cell line (A549), had the ability to become more damaged under AC magnetic field than the normal human lung cells (HFL-1).
authors.affiliation: National Taipei University of Technology, Institute of Materials Science and Engineering, Taipei, Taiwan.
authors.forename: Yo-Sheng
authors.initials: YS
authors.lastname: Chang
authors.forename: S
authors.initials: S
authors.lastname: Savitha
authors.forename: S
authors.initials: S
authors.lastname: Sadhasivam
authors.forename: Chung-King
authors.initials: CK
authors.lastname: Hsu
authors.forename: Feng-Huei
authors.initials: FH
authors.lastname: Lin
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D007501:Iron / Q000737:chemistry / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D060526:Magnetic Fields; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013440:Sulfides; C111959:greigite; D007501:Iron