title: [Experimental studies of therapeutic effect of Rheum officinale on acute pancreatitis].
abstract: OBJECTIVE
  To investigate the therapeutic effect of Rheum offĩcinale on acute pancreatitis.
  
  
  METHODS
  Buffered sodium taurocholate (3% m/V) was injected into the pancreatico-biliary duct to induce acute pancreatitis. Death rate,coefficient of pancreas, serum amylyse (AMY), hemocuprein (SOD), TNF-alpha and IL-1beta level were examined at 6, 12 and 24 hours after operations. Pathology analysis were also obtained.
  
  
  RESULTS
  Compared with corresponding pancreatitis groups,death rate, coefficient of pancreas, serum TNF-alpha and IL-1beta level of drug groups decreased remarkably (P < 0.05), while serum SOD level significantly increased (P < 0.01). Serum AMY level of drug groups increased at 6 h (P < 0.01), decreased at 12 h (P < 0.01) and had no statistics disparity at 24 h (P > 0.05) compared with respective pancreatitis group. Although score points of all drug groups were lower than corresponding pancreatitis groups, the growth tendency of both were similar.
  
  
  CONCLUSIONS
  Rheum officinale Baill has the effect of prevention to pancreas pathological changes in the animal pattern, but not able to reverse the tendency.
authors.affiliation: West China School of Pharmacy Sichuan University, Chengdu 610041, China. 11505011@163.com
authors.forename: Chang-yong
authors.initials: CY
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: Zhen-guo
authors.initials: ZG
authors.lastname: Xie
authors.forename: Xing
authors.initials: X
authors.lastname: Jiang
authors.forename: Nan
authors.initials: N
authors.lastname: Liang
authors.forename: Zhong-hua
authors.initials: ZH
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D000681:Amylases / Q000097:blood / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000473:pathology*; D010195:Pancreatitis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012250:Rheum; D020358:Sodium Cholate / Q000008:administration & dosage; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D013482:Superoxide Dismutase; D000681:Amylases; D020358:Sodium Cholate