title: Tracking down the molecular substrates of stress: new roles for p38α MAPK and kappa-opioid receptors.
abstract: In this issue, Bruchas et al. (2011) uncover a novel stress-induced p38α MAPK signaling cascade within serotonergic neurons of the dorsal raphe nucleus that mediates depressive and drug-seeking behaviors. Their findings have potentially important implications for medication development.
authors.affiliation: Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Muschamp
authors.forename: Ashlee
authors.initials: A
authors.lastname: Van't Veer
authors.forename: William A
authors.initials: WA
authors.lastname: Carlezon