title: Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2.
abstract: The three members of the amyloid precursor protein family in mammals [amyloid precursor protein, amyloid precursor-like protein 1, and amyloid precursor-like protein 2 (APLP2)] have been implicated in a large array of intracellular processes, which include development, transcription, apoptosis, metabolism, and the cell cycle. A series of studies by our laboratories has demonstrated that APLP2 is highly expressed by many cancer cell lines (with the highest expression in pancreatic cancer cell lines) and that it facilitates major histocompatibility complex (MHC) class I molecule endocytosis. This review focuses on this recently revealed function of APLP2 relevant to tumor immunology: that it acts as a novel regulator of MHC class I molecule surface expression.
authors.affiliation: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Haley L
authors.initials: HL
authors.lastname: Peters
authors.forename: Amit
authors.initials: A
authors.lastname: Tuli
authors.forename: Mahak
authors.initials: M
authors.lastname: Sharma
authors.forename: Naava
authors.initials: N
authors.lastname: Naslavsky
authors.forename: Steve
authors.initials: S
authors.lastname: Caplan
authors.forename: Richard G
authors.initials: RG
authors.lastname: MacDonald
authors.forename: Joyce C
authors.initials: JC
authors.lastname: Solheim
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000276:immunology*; D006801:Humans; D009363:Neoplasm Proteins / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000276:immunology* / Q000378:metabolism
chemical_list: C084104:APLP2 protein, human; D016564:Amyloid beta-Protein Precursor; D015395:Histocompatibility Antigens Class I; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins