title: Efficient sonochemical synthesis of alkyl 4-aryl-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate derivatives.
abstract: A facile, efficient and environment-friendly protocol for the synthesis of 6-chloro-5-formyl-1,4-dihydropyridine derivatives has been developed by the convenient ultrasound-mediated reaction of 2(1H)pyridone derivatives with the Vilsmeier-Haack reagent. This method provides several advantages over current reaction methodologies including a simpler work-up procedure, shorter reaction times and higher yields.
authors.affiliation: Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de La Habana, 10400-Ciudad Habana, Cuba.
authors.forename: Enrique
authors.initials: E
authors.lastname: Ruiz
authors.forename: Hortensia
authors.initials: H
authors.lastname: Rodríguez
authors.forename: Julieta
authors.initials: J
authors.lastname: Coro
authors.forename: Vladimir
authors.initials: V
authors.lastname: Niebla
authors.forename: Alfredo
authors.initials: A
authors.lastname: Rodríguez
authors.forename: Roberto
authors.initials: R
authors.lastname: Martínez-Alvarez
authors.forename: Hector Novoa
authors.initials: HN
authors.lastname: de Armas
authors.forename: Margarita
authors.initials: M
authors.lastname: Suárez
authors.forename: Nazario
authors.initials: N
authors.lastname: Martín
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D055772:Green Chemistry Technology; D008958:Models, Molecular; D008968:Molecular Conformation; D014465:Ultrasonics
chemical_list: D002264:Carboxylic Acids