title: [Dispersion behavior of effective ingredients in Chinese medicine decoctions].
abstract: OBJECTIVE
  To research the disperse behavior of many Chinese medicine decoctions.
  
  
  METHODS
  Through the analysis of the dispersible attributes of 22 kinds of Chinese medicine decoctions including Radix Salviae Miltiorrhizae by means of turbidity, ultramicroscope and TEM, we found that a lot of nanometer particles existed in these decoctions after 4000 r/min centrifugation. Based on the model of Radix Salviae Miltiorrhizae, we analyzed the influence on the loss of effective ingredients by way of centrifugation, alcohol precipitation, flocculation and salting-out edulcoration.
  
  
  RESULTS
  The removal of infinite nanometer particles from these decoctions led to the greater loss of water-soluble and fat-soluble ingredients,and the latter accounts for the major loss.
  
  
  CONCLUSIONS
  Oral liquid preparation of traditional Chinese medicine is a kind of nano-pharmaceutics with nanometer particles dispersed in the water as the carriers of effective ingredients in medicine.
authors.affiliation: Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China.
authors.forename: Mao-Lin
authors.initials: ML
authors.lastname: Wan
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Hong-Fei
authors.initials: HF
authors.lastname: Wu
authors.forename: Chuan-Hua
authors.initials: CH
authors.lastname: Lu
authors.forename: Yan-Ni
authors.initials: YN
authors.lastname: Fan
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
mesh_terms: D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*; D011786:Quality Control; D027561:Salvia miltiorrhiza / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical
chemical_list: D010936:Plant Extracts