title: Melanin biosynthesis inhibitors from Tarragon Artemisia dracunculus.
abstract: The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10-dynoic acid. The respective EC(50) values for melanin biosynthesis inhibition were 1.8 and 2.3 µg/mL for 1 and 2.
authors.affiliation: FANCL Research Institute, FANCL Corporation, Yokohama, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yamada
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Taeko
authors.initials: T
authors.lastname: Watabe
authors.forename: Osamu
authors.initials: O
authors.lastname: Ohno
authors.forename: Masaru
authors.initials: M
authors.lastname: Kawagoshi
authors.forename: Norihito
authors.initials: N
authors.lastname: Maru
authors.forename: Nobuo
authors.initials: N
authors.lastname: Uotsu
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Chiba
authors.forename: Kohji
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uemura
mesh_terms: D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014407:Tumor Cells, Cultured; D000521:alpha-MSH / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D008543:Melanins; D010936:Plant Extracts; D053284:Polyunsaturated Alkamides; D000521:alpha-MSH