title: Mechanism of action of the Adiana(®) device: a histologic perspective.
abstract: BACKGROUND
  The study was conducted to confirm the mechanism of action of the Adiana permanent contraception device by means of histologic analysis of long-term specimens.
  
  
  METHODS
  Fifteen specimens were obtained from eight subjects undergoing hysterectomy 2 to 4 years after the Adiana procedure. Serial sections were stained with hematoxylin and eosin, as well as epithelial membrane antigen immunostain.
  
  
  RESULTS
  A normal foreign body reaction with minimal chronic inflammatory changes was observed in all specimens. Immunostaining for epithelial membrane antigen was absent in the interstitial tissue surrounding the matrix.
  
  
  CONCLUSIONS
  Histologic analysis of long-term specimens supports the mechanism of action of the Adiana permanent contraception device.
authors.affiliation: University of New South Wales, Sydney, New South Wales, Australia. thierryvancaillie@mac.com
authors.forename: Thierry G
authors.initials: TG
authors.lastname: Vancaillie
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Harrington
authors.forename: James M
authors.initials: JM
authors.lastname: Anderson
mesh_terms: D000328:Adult; D003274:Contraceptive Devices, Female; D005187:Fallopian Tubes / Q000473:pathology / Q000601:surgery*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D011446:Prospective Studies; D013246:Sterilization, Tubal / Q000009:adverse effects / Q000295:instrumentation*