title: Serum unconjugated bisphenol A concentrations in men may influence embryo quality indicators during in vitro fertilization.
abstract: Here we assess bisphenol A (BPA) in couples undergoing in vitro fertilization (IVF) and indicators of embryo quality; embryo cell number (ECN) and embryo fragmentation score (EFS). Twenty-seven couples provided serum on the day of oocyte retrieval. Unconjugated BPA was measured by HPLC with Coularray detection. Odds ratios (OR) were generated using ordinal logistic regression including female and male BPA concentrations, age and race, and day of embryo transfer for ECN. Inverse associations are suggested for male BPA with ECN (OR=0.70, P=0.069), and EFS (OR=0.54, P=0.009), but not for women. Male BPA exposure may affect embryo quality during IVF.
authors.affiliation: Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY 12144, USA. mbloom@albany.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Bloom
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Vom Saal
authors.forename: Dongsul
authors.initials: D
authors.lastname: Kim
authors.forename: Julia A
authors.initials: JA
authors.lastname: Taylor
authors.forename: Julie D
authors.initials: JD
authors.lastname: Lamb
authors.forename: Victor Y
authors.initials: VY
authors.lastname: Fujimoto
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds; D004622:Embryo, Mammalian / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D004968:Estrogens, Non-Steroidal / Q000097:blood* / Q000494:pharmacology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010636:Phenols / Q000097:blood* / Q000494:pharmacology*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds