title: Supplementation before endoscopic therapy for esophageal varices reduces mental stress in patients with liver cirrhosis.
abstract: OBJECTIVE
  Esophageal varices are often seen in cirrhotic patients. Because endoscopic therapy for esophageal varices forces such patients to go on an extended fast until the endoscopic therapy occurs, physical and psychological stresses are induced. The aims of this study were to investigate the effects of a nutritional supplement before endoscopic therapy on such stresses, and on the safety of therapy.
  
  
  METHODS
  Thirty-six cirrhotic patients with esophageal varices were enrolled in this study and classified into two groups. In the fasting group, no energy was supplied to patients prior to endoscopic therapy (n=18). In the supplement group, a supplement of 200kcal was given prior to endoscopic therapy (n=18). The effects of the supplement on the safety of therapy and on stresses were evaluated by the endoscopist and by the self-rating questionnaire.
  
  
  RESULTS
  There were no significant differences in age, gender, BMI, or Child-Pugh score between the two groups. There was no interference with endoscopic therapy in the supplement group. Although physical symptoms were not significantly different between the two groups, stress scores for hypodynamia, was significantly lower in the supplement group than in the fasting group.
  
  
  CONCLUSIONS
  We first demonstrated that the supplementation before endoscopic therapy does not interfere with endoscopic treatment for esophageal varices in cirrhotic patients. Supplementation improves fasting-related hypodynamia.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Kurume, Japan. itou74m@med.kurume-u.ac.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Itou
authors.forename: Takumi
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Eitaro
authors.initials: E
authors.lastname: Taniguchi
authors.forename: Tetsuharu
authors.initials: T
authors.lastname: Oriishi
authors.forename: Takuro
authors.initials: T
authors.lastname: Suetsugu
authors.forename: Risa
authors.initials: R
authors.lastname: Hano
authors.forename: Miku
authors.initials: M
authors.lastname: Yoshihara
authors.forename: Midori
authors.initials: M
authors.lastname: Takishita
authors.forename: Mayumi
authors.initials: M
authors.lastname: Eguchi
authors.forename: Yukari
authors.initials: Y
authors.lastname: Ogiwara
authors.forename: Juri
authors.initials: J
authors.lastname: Otsuyama
authors.forename: Michiko
authors.initials: M
authors.lastname: Mutou
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ibi
authors.forename: Ryoko
authors.initials: R
authors.lastname: Akiyama
authors.forename: Midori
authors.initials: M
authors.lastname: Ono
authors.forename: Momoka
authors.initials: M
authors.lastname: Otsuka
authors.forename: Ayu
authors.initials: A
authors.lastname: Nagamatsu
authors.forename: Suiko
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kenji
authors.initials: K
authors.lastname: Miyakoda
authors.forename: Keigo
authors.initials: K
authors.lastname: Emori
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Morita
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kumamoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Tsuruta
authors.forename: Michio
authors.initials: M
authors.lastname: Sata
mesh_terms: D000368:Aged; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage; D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D005260:Female; D006801:Humans; D008026:Ligation; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D018529:Nutritional Support; D015911:Sclerotherapy; D013315:Stress, Psychological / Q000517:prevention & control*
chemical_list: D000597:Amino Acids, Branched-Chain