title: Azabicyclo[3.1.0]hexane-1-carbohydrazides as potent and selective GHSR1a ligands presenting a specific in vivo behavior.
authors.affiliation: Department of Medicinal Chemistry, Aptuit (S.r.l.), Via Fleming 4, 37135 Verona, Italy. fabio.m.sabbatini@aptuit.com
authors.forename: Fabio Maria
authors.initials: FM
authors.lastname: Sabbatini
authors.forename: Sergio
authors.initials: S
authors.lastname: Melotto
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bernasconi
authors.forename: Steve M
authors.initials: SM
authors.lastname: Bromidge
authors.forename: Lucilla
authors.initials: L
authors.lastname: D'Adamo
authors.forename: Marilisa
authors.initials: M
authors.lastname: Rinaldi
authors.forename: Chiara
authors.initials: C
authors.lastname: Savoia
authors.forename: Claudia
authors.initials: C
authors.lastname: Mundi
authors.forename: Carla
authors.initials: C
authors.lastname: Di Francesco
authors.forename: Laura
authors.initials: L
authors.lastname: Zonzini
authors.forename: Vivian J A
authors.initials: VJ
authors.lastname: Costantini
authors.forename: Benedetta
authors.initials: B
authors.lastname: Perini
authors.forename: Enzo
authors.initials: E
authors.lastname: Valerio
authors.forename: Alfonso
authors.initials: A
authors.lastname: Pozzan
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Perdonà
authors.forename: Filippo
authors.initials: F
authors.lastname: Visentini
authors.forename: Mauro
authors.initials: M
authors.lastname: Corsi
authors.forename: Romano
authors.initials: R
authors.lastname: Di Fabio
mesh_terms: D000818:Animals; D019167:Appetite Stimulants / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects*; D002942:Circular Dichroism; D004435:Eating / Q000187:drug effects*; D005260:Female; D054439:Ghrelin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006834:Hydrazines / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D008024:Ligands; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley; D054440:Receptors, Ghrelin / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D019167:Appetite Stimulants; D054439:Ghrelin; D006834:Hydrazines; D008024:Ligands; D054440:Receptors, Ghrelin; C019289:carbohydrazide