title: Lateral ridge augmentation using an equine flex bone block infused with recombinant human platelet-derived growth factor BB: a clinical and histologic study.
abstract: This paper reports on a patient who underwent horizontal ridge augmentation using recombinant human platelet-derived growth factor BB (rhPDGF-BB) in combination with a collagenate equine block. Ninety days after the first surgery, 8 mm of new bone was noted on a computed tomography scan, and three 5-mm implants were placed. Histology, performed using confocal laser scanning microscopy, showed a large amount of newly formed bone well characterized with osteon and resorption lacunae, which demonstrated the intense bone remodeling. This study supports the use of rhPDGF-BB in combination with allograft blocks.
authors.affiliation: University of Genova, Genova, Italy. nicola.deangelis@perio.org
authors.forename: Nicola
authors.initials: N
authors.lastname: De Angelis
authors.forename: Michele
authors.initials: M
authors.lastname: Scivetti
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000818:Animals; D000077214:Becaplermin; D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption / Q000473:pathology; D016025:Bone Transplantation / Q000379:methods* / Q000473:pathology; D003758:Dental Implantation, Endosseous; D005500:Follow-Up Studies; D006253:Haversian System / Q000473:pathology; D006736:Horses; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology; D020574:Proto-Oncogene Proteins c-sis / Q000627:therapeutic use*; D011994:Recombinant Proteins; D014057:Tomography, X-Ray Computed; D014183:Transplantation, Heterologous
chemical_list: D043925:Angiogenesis Inducing Agents; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin