title: 2-(3,5-Dihydroxyphenyl)-6-hydroxybenzothiazole arrests cell growth and cell cycle and induces apoptosis in breast cancer cell lines.
abstract: 2-Arylbenzothiazoles are an important class of bicyclic privileged substructures present in various natural or synthetic compounds that have been shown to possess anticancer, antifungal, antibacterial, anti-inflammatory, and antiallergic activities. This study examined the antiproliferative properties of 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole (DH) and its molecular mechanism of action in human breast cancer MDA-MB-231 cells. DH inhibits the growth of MDA-MB-231 cells with an IC(50) value of 25 μM in a dose/time-dependent manner as measured by the microculture tetrazolium method. Cell cycle analysis by flow cytometry showed that DH-induced growth arrest could be associated to apoptosis in MDA-MB-231 cells.
authors.affiliation: Department of Chemistry and Biochemistry, Islamic Azad University, Neyshabur, Iran. m.rajabi.s@gmail.com
authors.forename: Mehdi
authors.initials: M
authors.lastname: Rajabi
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D052160:Benzothiazoles / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure
chemical_list: C561204:2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole; D052160:Benzothiazoles