title: Vascular endothelial growth factor gene polymorphisms in Korean patients with premature ovarian failure.
abstract: OBJECTIVE
  To study the association of vascular endothelial growth factor (VEGF) polymorphisms (-2578C>A, -1154G>A, -634G>C, and 936C>T) with premature ovarian failure (POF) in Korean patients.
  
  
  METHODS
  Prospective case-control study. One hundred and thirty five patients with POF and confirmed serum follicle-stimulating hormone levels of >40IU/L before the age of 40 years and 120 healthy controls with at least one live birth, regular menstrual cycles, and karyotype 46, XX.
  
  
  RESULTS
  POF patients exhibited significantly different frequencies of the VEGF -1154GA genotype (odds ratio [OR], 2.002; 95% confidence interval [CI], 1.116-3.592; P=0.019), and -2578CA+AA/-1154GA+AA combination genotype (OR, 1.805; 95% CI, 1.013-3.217; P=0.044) compared to the control group. The frequency of the -2578A/-1154A haplotype (OR, 1.647; 95% CI, 1.017-2.677; P=0.041) was significantly higher in the POF group than in the control group.
  
  
  CONCLUSIONS
  The VEGF -1154G>A mutation, -2578CA+AA/-1154GA+AA combination genotype, and -2578A/-1154A haplotype are significantly associated with POF in Korean women.
authors.affiliation: Institute for Clinical Research, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea.
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Youngsok
authors.initials: Y
authors.lastname: Choi
authors.forename: Sung Han
authors.initials: SH
authors.lastname: Shim
authors.forename: Yi Seul
authors.initials: YS
authors.lastname: Choi
authors.forename: Jung Jae
authors.initials: JJ
authors.lastname: Ko
authors.forename: Tae Ki
authors.initials: TK
authors.lastname: Yoon
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Cha
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D005787:Gene Frequency; D056726:Genetic Association Studies; D006239:Haplotypes; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000235:genetics*; D011401:Promoter Regions, Genetic; D011446:Prospective Studies; D056910:Republic of Korea; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D043373:Follicle Stimulating Hormone, Human; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A