title: Concomitant autologous chondrocyte implantation with osteochondral grafting for treatment of a massive osteochondral defect in the bilateral knees of a child.
abstract: We report the case of a 15-year-old patient who underwent concomitant autologous chondrocyte implantation and osteochondral grafting for the treatment of a massive osteochondritis dissecans defect in the left knee and autologous chondrocyte implantation in the right knee joint. Magnetic resonance imaging showed large osteochondral defects in both the knee joints measuring 8-9 cm(2). Both defects were located in the weight-bearing areas of the medial femoral condyles. Therefore, simultaneous autologous chondrocyte implantation (ACI) and osteochondral autograft transplantation (OAT) for the left knee defect and ACI for the right knee joint were performed. Osteochondral plugs were harvested from the patellofemoral joint of the same left knee and grafted into the most dorsal regions of the large osteochondral defect of the left knee. The remaining osteochondral defect was covered with ACI using collagen type I and III membrane and chondrocyte cells. The membrane was implanted into more proximal part of the osteochondral defect of the left knee. Time interval between operations of the left and right knee joints was 6 months. Magnetic resonance imaging at 6 months after each knee surgery showed good preservation of the OAT and ACI grafts. The most recent follow-up examination, performed 12 months after surgeries, has shown excellent results with an International Knee Documentation Committee score of 95.59±4.64 and 96.88±4.69 for the right and left knee joints, respectively, and full range of knee motions with no symptoms. In this clinical case, the combination of ACI and OAT methods in a one-step procedure produced a good reconstruction of the joint surface with excellent clinical outcomes in the both knee joints of the same patient. Autologous osteochondral grafting and autologous chondrocyte implantation can be combined for the treatment of large osteochondral defects of the knee.
authors.affiliation: Department of Orthopedics and Traumatology, Medical Academy, Lithuanian University of Health Sciences. rimtautas.gudas@kaunoklinikos.lt
authors.forename: Rimtautas
authors.initials: R
authors.lastname: Gudas
authors.forename: Rasa
authors.initials: R
authors.lastname: Simonaitytė
authors.forename: Emilis
authors.initials: E
authors.lastname: Cekanauskas
authors.forename: Tomas
authors.initials: T
authors.lastname: Mickevičius
mesh_terms: D000293:Adolescent; D019902:Chondrocytes / Q000473:pathology / Q000637:transplantation*; D024042:Collagen Type I / Q000627:therapeutic use; D005269:Femur / Q000473:pathology; D006801:Humans; D007717:Knee / Q000473:pathology; D007719:Knee Joint / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010008:Osteochondritis Dissecans / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D014182:Transplantation, Autologous
chemical_list: D024042:Collagen Type I