title: Assessment of portal hypertension by transient elastography in patients with compensated cirrhosis and potentially resectable liver tumors.
abstract: OBJECTIVE
  Patients with cirrhosis and small hepatocellular carcinoma with normal bilirubin and hepatic venous pressure gradient (HVPG) <10 mm Hg have >70% 5-year survival after hepatic resection. On the contrary, patients with HVPG ≥10 mm Hg (clinically significant portal hypertension, CSPH) frequently develop decompensation following surgery, with around 50% 5-year survival. Liver stiffness (LS) evaluation by transient elastography might non-invasively identify CSPH. We investigated the usefulness of LS predicting CSPH in patients with compensated cirrhosis and potentially resectable liver tumors.
  
  
  METHODS
  Ninety-seven consecutive Child-Pugh A patients with potentially resectable liver tumors referred for HVPG measurement were prospectively evaluated. In fasting conditions LS was measured before the hemodynamic study.
  
  
  RESULTS
  HVPG could be measured in all patients, whereas LS could not be measured in 18 (18.5%) obese patients. In the 79 patients with valid LS, 32 (40.5%) had CSPH; mean HVPG was 8.8±4.7 mm Hg. Mean LS was 18.4±12.3 kPa. LS showed a moderate correlation with HVPG (r=0.552; p<0.001). LS<13.6 kPa had high sensitivity (91%) but low specificity (57%) excluding CSPH. Conversely, LS>21 kPa had low sensitivity (53%) and high specificity (91%) predicting CSPH. 35% of patients had LS between 13.6 and 21 kPa ("grey zone").
  
  
  CONCLUSIONS
  These data suggest that in real-life scenarios half of patients with potentially resectable liver nodules can be non-invasively classified as having or not CSPH by LS. However, in the remaining half, LS is either not applicable or inaccurate. In this last population HVPG is still a non replaceable method to detect CSPH.
authors.affiliation: Hepatic Hemodynamic Laboratory, Liver Unit, University of Barcelona, Spain.
authors.forename: Elba
authors.initials: E
authors.lastname: Llop
authors.forename: Annalisa
authors.initials: A
authors.lastname: Berzigotti
authors.forename: Maria
authors.initials: M
authors.lastname: Reig
authors.forename: Eva
authors.initials: E
authors.lastname: Erice
authors.forename: Enric
authors.initials: E
authors.lastname: Reverter
authors.forename: Susana
authors.initials: S
authors.lastname: Seijo
authors.forename: Juan G
authors.initials: JG
authors.lastname: Abraldes
authors.forename: Jordi
authors.initials: J
authors.lastname: Bruix
authors.forename: Jaime
authors.initials: J
authors.lastname: Bosch
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: García-Pagan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000150:complications; D015331:Cohort Studies; D054459:Elasticity Imaging Techniques; D005260:Female; D006503:Hepatic Veins / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications* / Q000000981:diagnostic imaging*; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies