title: Potential role of Jun activation domain-binding protein 1 and phosphorylated p27 expression in prognosis of glioma.
abstract: To investigate whether Jun activation domain-binding protein 1 (Jab1) expression is correlated with p27 protein and its phosphorylation status as well as how it might be clinically relevant in glioma, we carried out an immunohistochemical study of Jab1, Ser10-phosphorylated p27 (pSer10p27), and p27 using biopsies from 192 patients with primary glioma. Kaplan-Meier survival and Cox regression analyses were performed to evaluate the prognosis of patients. Immunostaining revealed a positive correlation between Jab1 and cytoplasmic p27 as well as pSer10p27 in all glioma cases. In addition, patients displaying the overexpression of Jab1, cytoplasmic p27, and pSer10p27 were significantly associated with unfavorable clinicopathological variables. Statistical analysis showed that patients expressing Jab1, cytoplasmic p27, and pSer10p27 have poor overall survival rates relative to those not expressing these proteins. Cox multifactor analysis showed that Jab1 (P = 0.006), cytoplasmic p27 (P = 0.01), and pSer10p27 (P = 0.009) were independent prognosis factors for human glioma. In conclusion, the current results showed convincing evidence that the overexpression of Jab1, cytoplasmic p27, and pSer10p27 proteins is correlated with poor outcome in patients with glioma and that these three proteins may be useful markers to predict the prognosis of this tumor.
authors.affiliation: Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China.
authors.forename: Shi-Ming
authors.initials: SM
authors.lastname: He
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Zhao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Ji-Pei
authors.initials: JP
authors.lastname: Zhao
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Hou
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Gao
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality; D000075686:COP9 Signalosome Complex; D005260:Female; D005910:Glioma / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010447:Peptide Hydrolases / Q000032:analysis / Q000096:biosynthesis*; D010766:Phosphorylation; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis / Q000096:biosynthesis*; D016016:Proportional Hazards Models
chemical_list: D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; D018809:Proliferating Cell Nuclear Antigen; C413374:p27 antigen; D010447:Peptide Hydrolases; C501488:COPS5 protein, human; D000075686:COP9 Signalosome Complex