title: SEOM clinical guidelines for the treatment of anal cancer.
abstract: Anal carcinoma is an uncommon disorder accounting for less than 2% of large bowel malignancies and 1-6% of anorectal tumours. Its incidence ranges between 0.5 and 1% per 100,000. Local staging should be done with MR imaging using an external pelvic phased-array coil. Treatment strategy should be optimally discussed in a multidisciplinary team. HIV-positive patients seem to achieve similar response rate and overall survival to HIV-negative patients but with increased toxicity and higher local recurrences. Combined modality treatment with irradiation and chemotherapy has resulted in complete response over 90% and local control over 85%. This guide gives recommendations for diagnosis, staging and treatment.
authors.affiliation: Medical Oncology Department, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain. jmaurel@clinic.ub.es
authors.forename: Joan
authors.initials: J
authors.lastname: Maurel
authors.forename: Carlos
authors.initials: C
authors.lastname: Fernández-Martos
authors.forename: Jaime
authors.initials: J
authors.lastname: Feliu
authors.forename: Dolores
authors.initials: D
authors.lastname: Isla
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D001005:Anus Neoplasms / Q000150:complications / Q000628:therapy*; D002277:Carcinoma / Q000150:complications / Q000628:therapy; D003131:Combined Modality Therapy / Q000379:methods; D015658:HIV Infections / Q000150:complications / Q000628:therapy; D006801:Humans; D008495:Medical Oncology / Q000379:methods*; D012955:Societies, Medical; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents