title: Current and future use of genomics data in toxicology: opportunities and challenges for regulatory applications.
abstract: Toxicogenomics is the application of toxicology, genetics, molecular biology and environmental health to describe the response of organisms to environmental stimuli. The field of toxicogenomics has developed over the past 15 years mainly due to advances in toxicology, molecular genetics and cell biology. Its prospective use to resolve crucial data gaps and data inconsistencies could improve risk assessment by providing additional data to increase the understanding of mechanisms and modes of action (MOA) and enhance the reliability of dose-response extrapolation. Thus, toxicogenomics holds promise for advancing the scientific basis of risk assessments. However, one of the current issues is how genomic/transcriptional data is being used to further describe a MOA for oncogenicity and, in turn, its potential uses in cancer risk assessment. This commentary identifies how toxicogenomics could be used on a case by case basis to add information to a MOA addressing both the opportunities and challenges this technology holds. In addition, some pitfalls to avoid in the generation and interpretation of toxicogenomic data and validation issues that need to be addressed before toxicogenomics can be used in the risk assessment process and regulatory decisions are discussed.
authors.affiliation: Syngenta Crop Protection, LLC, Greensboro, NC 27419, USA. mber.goetz@syngenta.com
authors.forename: Amber K
authors.initials: AK
authors.lastname: Goetz
authors.forename: Bhanu P
authors.initials: BP
authors.lastname: Singh
authors.forename: Michael
authors.initials: M
authors.lastname: Battalora
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Breier
authors.forename: Jason P
authors.initials: JP
authors.lastname: Bailey
authors.forename: Amechi C
authors.initials: AC
authors.lastname: Chukwudebe
authors.forename: Erik R
authors.initials: ER
authors.lastname: Janus
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods / Q000639:trends; D043922:Toxicogenetics / Q000379:methods* / Q000639:trends; D014116:Toxicology / Q000379:methods* / Q000639:trends