title: Clinical impact of albuminuria in diabetic nephropathy.
abstract: Patients suffering from diabetic nephropathy, resulting in end-stage renal failure, are increasing in number. The pathophysiology of diabetic nephropathy remains to be fully investigated. In the clinical setting, the presence of albuminuria/overt proteinuria and a low glomerular filtration rate may predict poor renal prognosis, but the prognosis of the normoalbuminuric renally insufficient diabetic patient remains controversial. In addition to the measurement of urinary albumin excretion, biomarker studies to detect diabetic nephropathy more specifically at the early stage have been performed worldwide. There is a growing body of evidence for remission and/or regression of diabetic nephropathy, which may be an indicator for cardiovascular and renal risk reduction. Deeper insights into the pathological characteristics as well as the clinical impact of albuminuria on renal and cardiovascular outcome are required.
authors.affiliation: Division of Nephrology, Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan. twada@m-kanazawa.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
authors.forename: Miho
authors.initials: M
authors.lastname: Shimizu
authors.forename: Tadashi
authors.initials: T
authors.lastname: Toyama
authors.forename: Akinori
authors.initials: A
authors.lastname: Hara
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kaneko
authors.forename: Kengo
authors.initials: K
authors.lastname: Furuichi
mesh_terms: D000419:Albuminuria / Q000453:epidemiology / Q000503:physiopathology*; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000503:physiopathology*; D005919:Glomerular Filtration Rate; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007668:Kidney / Q000503:physiopathology; D011379:Prognosis; D011507:Proteinuria / Q000503:physiopathology; D012074:Remission Induction
chemical_list: D015415:Biomarkers