title: Doubly hydrophilic multiarm hyperbranched polymers with acylhydrazone linkages as acid-sensitive drug carriers.
abstract: A novel type of drug carrier capable of controlled drug release is proposed. It consists of an acid-sensitive doubly hydrophilic multiarm hyperbranched copolymer with a hyperbranched polyamidoamine core and many linear poly(ethylene glycol) arms. Using pH-sensitive acylhydrazone linkages, the polymer forms unimolecular micelles that can encapsulate hydrophobic drugs. Due to their amphiphilicity, the drug-loaded unimolecular micelles can self-assemble into multimolecular micelles that show acid-triggered intracellular delivery of the hydrophobic drugs.
authors.affiliation: Department of Children's Oral, the Stomatology, College of Haerbin Medical University, Nangang District, Haerbin, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhu
authors.forename: Guolin
authors.initials: G
authors.lastname: Li
authors.forename: Chunlai
authors.initials: C
authors.lastname: Tu
authors.forename: Yan
authors.initials: Y
authors.lastname: Pang
authors.forename: Chengyu
authors.initials: C
authors.lastname: Jin
authors.forename: Bangshang
authors.initials: B
authors.lastname: Zhu
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Zhu
authors.forename: Yingqun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D016475:3T3 Cells; D000143:Acids / Q000737:chemistry; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D050091:Dendrimers / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D004058:Diffusion; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D004339:Drug Compounding / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D006835:Hydrazones / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry; D012996:Solutions
chemical_list: D000143:Acids; D003692:Delayed-Action Preparations; D050091:Dendrimers; D004337:Drug Carriers; D006835:Hydrazones; D008823:Micelles; C104700:PAMAM Starburst; D012996:Solutions; D011092:Polyethylene Glycols; D004317:Doxorubicin