title: Registration of the endoluminal surfaces of the colon derived from prone and supine CT colonography.
abstract: OBJECTIVE
  Computed tomographic (CT) colonography is a relatively new technique for detecting bowel cancer or potentially precancerous polyps. CT scanning is combined with three-dimensional (3D) image reconstruction to produce a virtual endoluminal representation similar to optical colonoscopy. Because retained fluid and stool can mimic pathology, CT data are acquired with the bowel cleansed and insufflated with gas and patient in both prone and supine positions. Radiologists then match visually endoluminal locations between the two acquisitions in order to determine whether apparent pathology is real or not. This process is hindered by the fact that the colon, essentially a long tube, can undergo considerable deformation between acquisitions. The authors present a novel approach to automatically establish spatial correspondence between prone and supine endoluminal colonic surfaces after surface parameterization, even in the case of local colon collapse.
  
  
  METHODS
  The complexity of the registration task was reduced from a 3D to a 2D problem by mapping the surfaces extracted from prone and supine CT colonography onto a cylindrical parameterization. A nonrigid cylindrical registration was then performed to align the full colonic surfaces. The curvature information from the original 3D surfaces was used to determine correspondence. The method can also be applied to cases with regions of local colonic collapse by ignoring the collapsed regions during the registration.
  
  
  RESULTS
  Using a development set, suitable parameters were found to constrain the cylindrical registration method. Then, the same registration parameters were applied to a different set of 13 validation cases, consisting of 8 fully distended cases and 5 cases exhibiting multiple colonic collapses. All polyps present were well aligned, with a mean (+/- std. dev.) registration error of 5.7 (+/- 3.4) mm. An additional set of 1175 reference points on haustral folds spread over the full endoluminal colon surfaces resulted in an error of 7.7 (+/- 7.4) mm. Here, 82% of folds were aligned correctly after registration with a further 15% misregistered by just onefold.
  
  
  CONCLUSIONS
  The proposed method reduces the 3D registration task to a cylindrical registration representing the endoluminal surface of the colon. Our algorithm uses surface curvature information as a similarity measure to drive registration to compensate for the large colorectal deformations that occur between prone and supine data acquisitions. The method has the potential to both enhance polyp detection and decrease the radiologist's interpretation time.
authors.affiliation: Centre for Medical Image Computing, University College London, London WC1E 6BT, United Kingdom. h.roth@ucl.ac.uk
authors.forename: Holger R
authors.initials: HR
authors.lastname: Roth
authors.forename: Jamie R
authors.initials: JR
authors.lastname: McClelland
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Boone
authors.forename: Marc
authors.initials: M
authors.lastname: Modat
authors.forename: M Jorge
authors.initials: MJ
authors.lastname: Cardoso
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Hampshire
authors.forename: Mingxing
authors.initials: M
authors.lastname: Hu
authors.forename: Shonit
authors.initials: S
authors.lastname: Punwani
authors.forename: Sebastien
authors.initials: S
authors.lastname: Ourselin
authors.forename: Greg G
authors.initials: GG
authors.lastname: Slabaugh
authors.forename: Steve
authors.initials: S
authors.lastname: Halligan
authors.forename: David J
authors.initials: DJ
authors.lastname: Hawkes
mesh_terms: D003106:Colon / Q000000981:diagnostic imaging* / Q000473:pathology; D003111:Colonic Polyps / Q000000981:diagnostic imaging / Q000473:pathology; D023881:Colonography, Computed Tomographic / Q000379:methods*; D006801:Humans; D016684:Prone Position; D015203:Reproducibility of Results; D016683:Supine Position