title: On the chromatin structure of eukaryotic telomeres.
abstract: Telomeres prevent chromosome fusions and degradation by exonucleases and are implicated in DNA repair, homologous recombination, chromosome pairing and segregation. All these functions of telomeres require the integrity of their chromatin structure, which has been traditionally considered as heterochromatic. In agreement with this idea, different studies have reported that telomeres associate with heterochromatic marks. However, these studies addressed simultaneously the chromatin structures of telomeres and subtelomeric regions or the chromatin structure of telomeres and Interstitial Telomeric Sequences (ITSs). The independent analysis of Arabidopsis telomeres, subtelomeric regions and ITSs has allowed the discovery of euchromatic telomeres. In Arabidopsis, whereas subtelomeric regions and ITSs associate with heterochromatic marks, telomeres exhibit euchromatic features. We think that this scenario could be found in other model systems if the chromatin organizations of telomeres, subtelomeric regions and ITSs are independently analyzed.
authors.affiliation: Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla-CSIC, Seville, Spain.
authors.forename: María I
authors.initials: MI
authors.lastname: Vaquero-Sedas
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Vega-Palas
mesh_terms: D017360:Arabidopsis / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics; D042002:Chromatin Assembly and Disassembly; D047369:Chromatin Immunoprecipitation / Q000379:methods; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000737:chemistry / Q000235:genetics; D016615:Telomere / Q000737:chemistry* / Q000235:genetics
chemical_list: D002843:Chromatin