title: [Hereditary susceptibility to endometrial cancer].
abstract: OBJECTIVE
  To present up-to-date knowledge concerning field of hereditary susceptibility to endometrial cancer as a part of hereditary non-polyposis colorectal cancer (Lynch syndrome).
  
  
  METHODS
  Review.
  
  
  METHODS
  Oncogynecological Center, Department of Obstetrics and Gynecology, Charles University in Prague, First Faculty of Medicine and General Faculty Hospital, Prague.
  
  
  METHODS
  After having gone over the now-a-days literature and summarized our experience with management of high risk women of Lynch syndrome families we present up-to-date overview of this field problematics.
  
  
  CONCLUSIONS
  Although endometrial cancer arising due to germ-line susceptibility account for a small part of these malignancies only, they represent disease with clearly defined and detectable serious risk factor. Management approach for these women is now defined and allows for early detection or lowering the risk. Educated gynecologist, as a field specialist, has good chance to identify women at risk and manage them in an appropriate way.
authors.affiliation: Onkogynekologické centrum, Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha. michal.zikan@lf1.cuni.cz
authors.forename: M
authors.initials: M
authors.lastname: Zikán
authors.forename: J
authors.initials: J
authors.lastname: Sláma
authors.forename: I
authors.initials: I
authors.lastname: Pinkavová
authors.forename: D
authors.initials: D
authors.lastname: Fischerová
authors.forename: P
authors.initials: P
authors.lastname: Freitag
authors.forename: D
authors.initials: D
authors.lastname: Cibula
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D053843:DNA Mismatch Repair / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D009154:Mutation