title: Prevention of gastroduodenal content reflux and delayed gastric emptying after esophagectomy: gastric tube reconstruction with duodenal diversion plus Roux-en-Y anastomosis.
abstract: Reflux of gastroduodenal contents and delayed gastric emptying are the most common and serious problems after esophagectomy with gastric reconstruction. However, attempts to reduce the above symptoms, surgically as well as non-surgically, had no or limited effect. To address this issue, we performed retrosternal gastric reconstruction with duodenal diversion plus Roux-en-Y anastomosis (RY) in eight patients with thoracic esophageal cancer and compared the outcomes with control patients who underwent standard reconstruction. The procedure is simple, safe, and not associated with any postoperative complications. The pancreatic amylase concentrations in the gastric juice samples on postoperative day 2 were slightly lower in the non-RY group than in the RY group (1884 ± 2152 vs. 25,790 ± 23,542IU/mL, respectively, P= 0.07). Postoperative endoscopic examination showed neither reflux esophagitis nor residual gastric content in the RY group. Quality of life assessed by the Dysfunction After Upper Gastrointestinal Surgery-32 questionnaire postoperatively was significantly better in the RY group than in the non-RY group for 'decreased physical activity,''symptoms of reflux,''nausea and vomiting,' and 'pain.' The results of this pilot study suggest that gastric reconstruction with duodenal diversion plus RY seems effective in improving both the reflux and delayed gastric emptying. The benefits of this procedure need to be further assessed in a large-scale, randomized controlled trial.
authors.affiliation: Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. yano-ma@mc.pref.osaka.jp
authors.forename: M
authors.initials: M
authors.lastname: Yano
authors.forename: M
authors.initials: M
authors.lastname: Motoori
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Kishi
authors.forename: I
authors.initials: I
authors.lastname: Miyashiro
authors.forename: T
authors.initials: T
authors.lastname: Shingai
authors.forename: K
authors.initials: K
authors.lastname: Gotoh
authors.forename: S
authors.initials: S
authors.lastname: Noura
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Ohue
authors.forename: H
authors.initials: H
authors.lastname: Ohigashi
authors.forename: O
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000368:Aged; D000681:Amylases / Q000378:metabolism; D000713:Anastomosis, Roux-en-Y; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D004383:Duodenogastric Reflux / Q000209:etiology / Q000517:prevention & control*; D004386:Duodenum / Q000601:surgery; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy / Q000009:adverse effects*; D004944:Esophagoplasty / Q000379:methods*; D005260:Female; D015390:Gastric Bypass; D005746:Gastric Emptying; D005750:Gastric Juice / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009325:Nausea / Q000209:etiology; D010149:Postoperative Pain / Q000209:etiology; D010865:Pilot Projects; D011788:Quality of Life; D020127:Recovery of Function; D012189:Retrospective Studies; D013270:Stomach / Q000601:surgery; D011795:Surveys and Questionnaires; D014839:Vomiting / Q000209:etiology
chemical_list: D000681:Amylases