title: Delivery of plant-made vaccines and therapeutics.
abstract: As commercial approval of the first, purified, plant-based biopharmaceuticals for parenteral delivery to humans approaches, improved strategies for delivery of plant-made vaccines and therapeutics are required to ensure their further development and to fulfil the prospect of supplying a global solution for affordable medicines. To ensure that this occurs, research should investigate and characterise the host immune system in addition to the effects of adjuvants and carrier vehicles on consistency and efficacy of vaccination. In this review we explore the basic understandings of pharmaceutical delivery and its effect on immunogenicity in an effort to advance the plant-made pharmaceutical platform.
authors.affiliation: School of Biological Sciences, Monash University, Clayton, Victoria, Australia. assunta.pelosi@monash.edu
authors.forename: Assunta
authors.initials: A
authors.lastname: Pelosi
authors.forename: Robert
authors.initials: R
authors.lastname: Shepherd
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Walmsley
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000284:Administration, Oral; D000818:Animals; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D006801:Humans; D018928:Immunity, Mucosal; D023421:Models, Animal; D030821:Plants, Genetically Modified / Q000235:genetics* / Q000378:metabolism; D014611:Vaccination / Q000379:methods*; D014612:Vaccines / Q000096:biosynthesis*
chemical_list: D000276:Adjuvants, Immunologic; D014612:Vaccines