title: The contribution of imaging genetics to the development of predictive markers for addictions.
abstract: A key challenge for intervention and prevention of addictions is the identification of genetic, neurobiological and cognitive risk profiles that can predict which adolescents are at risk for addiction. Abnormalities in reinforcement behaviour have been linked to addiction vulnerability and imaging genetic studies have begun to elucidate the mechanisms by which genetic and environmental factors influence brain function underlying individual variability in reinforcement behaviour. Most studies have examined associations between a few well-characterised candidate polymorphisms and task-related brain activation differences in individual regions of interest. Here we propose that integrating the imaging genetic strategy with biological network approaches and longitudinal adolescent designs in large multi-centre samples may offer promising opportunities to identify risk markers for early diagnosis, progression and prediction of addictions.
authors.affiliation: MRC-SGDP-Centre, Institute of Psychiatry, King's College, London SE5 8AF, UK.
authors.forename: Eva
authors.initials: E
authors.lastname: Loth
authors.forename: Fabiana
authors.initials: F
authors.lastname: Carvalho
authors.forename: Gunter
authors.initials: G
authors.lastname: Schumann
mesh_terms: D015415:Biomarkers; D001921:Brain / Q000254:growth & development / Q000473:pathology*; D003072:Cognition Disorders / Q000209:etiology / Q000235:genetics / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007206:Individuality; D007266:Inhibition, Psychological; D059906:Neuroimaging; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D012054:Reinforcement, Psychology; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications / Q000235:genetics* / Q000473:pathology* / Q000628:therapy
chemical_list: D015415:Biomarkers