title: Genomics of iron acquisition in the plant pathogen Erwinia amylovora: insights in the biosynthetic pathway of the siderophore desferrioxamine E.
abstract: Genomics has clarified the biosynthetic pathway for desferrioxamine E critical for iron acquisition in the enterobacterial fire blight pathogen Erwinia amylovora. Evidence for each of the individual steps and the role of desferrioxamine E biosynthesis in pathogen virulence and cell protection from host defenses is presented. Using comparative genomics, it can be concluded that desferrioxamine biosynthesis is ancestral within the genera Erwinia and Pantoea.
authors.affiliation: Plant Protection Division, Agroscope Changins-Wädenswil ACW, 8820, Wädenswil, Switzerland. theo.smits@acw.admin.ch
authors.forename: Theo H M
authors.initials: TH
authors.lastname: Smits
authors.forename: Brion
authors.initials: B
authors.lastname: Duffy
mesh_terms: D053898:Biosynthetic Pathways; D003676:Deferoxamine / Q000378:metabolism*; D044084:Erwinia amylovora / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D023281:Genomics; D007501:Iron / Q000378:metabolism*; D005810:Multigene Family; D020636:Pantoea / Q000235:genetics / Q000378:metabolism; D017262:Siderophores / Q000096:biosynthesis*; D014774:Virulence / Q000235:genetics
chemical_list: D017262:Siderophores; D007501:Iron; D003676:Deferoxamine