title: The effects of prenatal methamphetamine exposure on childhood growth patterns from birth to 3 years of age.
abstract: We examined the effects of prenatal methamphetamine (MA) exposure on growth parameters from birth to age 3 years. The 412 subjects included (n = 204 exposed) were enrolled at birth in the Infant Development, Environment and Lifestyle study, a longitudinal study assessing the effects of prenatal MA exposure on childhood outcomes. Individual models were used to examine the effects of prenatal MA exposure on weight, head circumference, height, and weight-for-length growth trajectories. After adjusting for covariates, height trajectory was lower in the exposed versus the comparison children (p = 0.021) over the first 3 years of life. Both groups increased height on average by 2.27 cm per month by age 3 years. In term subjects, MA exposure was also associated with a lower height trajectory (p = 0.034), with both the exposed and comparison groups gaining 2.25 cm per month by age 3 years. There was no difference in weight, head circumference, or weight-for-length growth trajectories between the comparison and the exposed groups. Children exposed prenatally to MA have a modest decrease in height growth trajectory during the first 3 years of life with no observed difference in weight, head circumference, or weight-for-length trajectories.
authors.affiliation: Los Angeles Biomedical Institute at Harbor-UCLA Medical Center, California, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Zabaneh
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Smith
authors.forename: Linda L
authors.initials: LL
authors.lastname: LaGasse
authors.forename: Chris
authors.initials: C
authors.lastname: Derauf
authors.forename: Elana
authors.initials: E
authors.lastname: Newman
authors.forename: Rizwan
authors.initials: R
authors.lastname: Shah
authors.forename: Amelia
authors.initials: A
authors.lastname: Arria
authors.forename: Marilyn
authors.initials: M
authors.lastname: Huestis
authors.forename: William
authors.initials: W
authors.lastname: Haning
authors.forename: Arthur
authors.initials: A
authors.lastname: Strauss
authors.forename: Sheri
authors.initials: S
authors.lastname: Della Grotta
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Dansereau
authors.forename: Hai
authors.initials: H
authors.lastname: Lin
authors.forename: Charles
authors.initials: C
authors.lastname: Neal
authors.forename: Barry M
authors.initials: BM
authors.lastname: Lester
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000187:drug effects; D049628:Body Size / Q000187:drug effects; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine