title: Cytogenetic and comparative genomic hybridization studies of an esophageal giant fibrovascular polyp: a case report.
abstract: Esophageal giant fibrovascular polyps are rare and are thought to represent redundant tumorlike or hamartomatous esophageal folds. Although most patients present with slowly evolving dysphagia, a minority present with acute respiratory distress or even death caused by asphyxia. We present the pathologic and cytogenetic findings of an 18-cm esophageal giant fibrovascular polyp in a 49-year-old woman who presented with odynophagia and dysphagia. The histologic findings are that of classic esophageal giant fibrovascular polyp as previously described in the literature. Cytogenetic study revealed an abnormal karyotype, and comparative genomic hybridization analysis showed regional amplifications of chromosomes 3 and 12 and a possible loss of 22q13.3-qter. The significance of these cytogenetic findings is unclear but may suggest a neoplastic process in the pathogenesis of esophageal giant fibrovascular polyps.
authors.affiliation: Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. zhongxin-yu@ouhsc.edu
authors.forename: Zhongxin
authors.initials: Z
authors.lastname: Yu
authors.forename: Barbara L
authors.initials: BL
authors.lastname: Bane
authors.forename: Ji-Yun
authors.initials: JY
authors.lastname: Lee
authors.forename: Jan V
authors.initials: JV
authors.lastname: Pitha
authors.forename: Marvin
authors.initials: M
authors.lastname: Peyton
authors.forename: John
authors.initials: J
authors.lastname: Houck
authors.forename: Shibo
authors.initials: S
authors.lastname: Li
mesh_terms: D059786:Abnormal Karyotype; D002881:Chromosomes, Human, Pair 12; D002893:Chromosomes, Human, Pair 3; D055028:Comparative Genomic Hybridization / Q000379:methods*; D003680:Deglutition Disorders / Q000235:genetics / Q000473:pathology / Q000601:surgery; D004935:Esophageal Diseases / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy; D004947:Esophagus / Q000473:pathology*; D005260:Female; D005784:Gene Amplification; D006801:Humans; D008875:Middle Aged; D011127:Polyps / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D012303:Ring Chromosomes; D016896:Treatment Outcome