title: Potential role of serine proteases in modulating renal sodium transport in vivo.
abstract: The maintenance of sodium (Na+) homeostasis is an essential function of the kidney. It is achieved by a variety of transport processes localized all along the highly specialised segments of the nephron. Impairment of these transport mechanisms, and thereby Na+ handling, is associated with disturbed Na+ and water balance, leading to hypertension and oedema. This review focuses on the novel regulation of sodium reabsorption by serine proteases acting along the entire nephron.
authors.affiliation: UCL Centre for Nephrology, Royal Free Hospital, University College London, Medical School, London, UK. g.jacquillet@medsch.ucl.ac.uk
authors.forename: G
authors.initials: G
authors.lastname: Jacquillet
authors.forename: I
authors.initials: I
authors.lastname: Rubera
authors.forename: R J
authors.initials: RJ
authors.lastname: Unwin
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D005341:Fibrinolysin / Q000652:urine; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008954:Models, Biological; D009399:Nephrons / Q000378:metabolism*; D009404:Nephrotic Syndrome / Q000378:metabolism / Q000503:physiopathology / Q000652:urine; D010958:Plasminogen; D057057:Serine Proteases / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
chemical_list: D010958:Plasminogen; D012964:Sodium; D057057:Serine Proteases; D005341:Fibrinolysin