title: Analysis of coronary angiography related psychophysiological responses.
abstract: BACKGROUND
  Coronary angiography is an important tool in diagnosis of cardiovascular diseases. However, it is the administration is relatively stressful and emotionally traumatic for the subjects. The aim of this study is to evaluate psychophysiological responses induced by the coronary angiography instead of subjective methods such as a questionnaire. We have also evaluated the influence of the tranquilizer on the psychophysiological responses.
  
  
  METHODS
  Electrocardiography (ECG), Blood Volume Pulse (BVP), and Galvanic Skin Response (GSR) of 34 patients who underwent coronary angiography operation were recorded. Recordings were done at three phases: "1 hour before," "during," and "1 hour after" the coronary angiography test. Total of 5 features obtained from the physiological signals were compared across these three phases. Sixteen of the patients were administered 5 mg of a tranquilizer (Diazepam) before the operation and remaining 18 were not.
  
  
  RESULTS
  Our results indicate that there is a strong correlation between features (LF/HF, Bk, DN1/DN2, skin conductance level and seg_mean) in terms of reflecting psychophysiological responses. However only DN1/DN2 feature has statistically significant differences between angiography phases (for diazepam: p = 0.0201, for non_diazepam p = 0.0224). We also note that there are statistically significant differences between the diazepam and non-diazepam groups for seg_mean features in "before", "during" and "after" phases (p = 0.0156, 0.0282, and 0.0443, respectively).
  
  
  CONCLUSIONS
  The most intense sympathetic activity is observed in the "during" angiography phase for both of the groups. The obtained features can be used in some clinical studies where generation of the customized/individual diagnoses styles and quantitative evaluation of psychophysiological responses is necessary.
authors.affiliation: Institute of Biomedical Engineering, Fatih University, Buyukcekmece, Istanbul, 34500, Turkey. sukruokkesim@fatih.edu.tr
authors.forename: Şükrü
authors.initials: Ş
authors.lastname: Okkesim
authors.forename: Sadik
authors.initials: S
authors.lastname: Kara
authors.forename: Mehmet G
authors.initials: MG
authors.lastname: Kaya
authors.forename: Musa H
authors.initials: MH
authors.lastname: Asyali
mesh_terms: D000368:Aged; D000792:Angiography / Q000187:drug effects; D017023:Coronary Angiography / Q000379:methods*; D003975:Diazepam / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D005712:Galvanic Skin Response / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011603:Psychophysiology
chemical_list: D003975:Diazepam