title: [Mitochondrial dynamics: a potential new therapeutic target for heart failure].
abstract: Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. These events allow the transmission of signaling messengers and exchange of metabolites within the cell. They have also been implicated in a variety of biological processes including embryonic development, metabolism, apoptosis, and autophagy. Although the majority of these studies have been confined to noncardiac cells, emerging evidence suggests that changes in mitochondrial morphology could participate in cardiac development, the response to ischemia-reperfusion injury, heart failure, and diabetes mellitus. In this article, we review how the mitochondrial dynamics are altered in different cardiac pathologies, with special emphasis on heart failure, and how this knowledge may provide new therapeutic targets for treating cardiovascular diseases.
authors.affiliation: Centro Estudios Moleculares de la Célula, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
authors.forename: Jovan
authors.initials: J
authors.lastname: Kuzmicic
authors.forename: Andrea
authors.initials: A
authors.lastname: Del Campo
authors.forename: Camila
authors.initials: C
authors.lastname: López-Crisosto
authors.forename: Pablo E
authors.initials: PE
authors.lastname: Morales
authors.forename: Christian
authors.initials: C
authors.lastname: Pennanen
authors.forename: Roberto
authors.initials: R
authors.lastname: Bravo-Sagua
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hechenleitner
authors.forename: Ramiro
authors.initials: R
authors.lastname: Zepeda
authors.forename: Pablo F
authors.initials: PF
authors.lastname: Castro
authors.forename: Hugo E
authors.initials: HE
authors.lastname: Verdejo
authors.forename: Valentina
authors.initials: V
authors.lastname: Parra
authors.forename: Mario
authors.initials: M
authors.lastname: Chiong
authors.forename: Sergio
authors.initials: S
authors.lastname: Lavandero
mesh_terms: D017209:Apoptosis / Q000502:physiology; D006333:Heart Failure / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology