title: Antiplasmodial indole alkaloids from Leuconotis griffithii.
abstract: A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falciparum 3D7 of indole alkaloids isolated from L. griffithii was investigated.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Alfarius E
authors.initials: AE
authors.lastname: Nugroho
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Wong Chin
authors.initials: WC
authors.lastname: Piow
authors.forename: Toshio
authors.initials: T
authors.lastname: Kaneda
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirota
authors.forename: Wiwied
authors.initials: W
authors.lastname: Ekasari
authors.forename: Aty
authors.initials: A
authors.lastname: Widyawaruyanti
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D026121:Indole Alkaloids; D010936:Plant Extracts