title: Structural revision of periplocosides and periperoxides, natural immunosuppressive agents from the genus Periploca.
abstract: The structures of a series of peroxy function containing pregnane glycosides isolated from Periploca sepium and Periploca forrestii were revised to be orthoester group bearing ones using 2D NMR spectroscopic techniques, as well as chemical transformations and X-ray crystallographic diffraction analysis. The orthoester function appears to be an essential structural feature for immunosuppressive activity.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
authors.forename: Luo-Yi
authors.initials: LY
authors.lastname: Wang
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zuo
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Zhao
mesh_terms: D018360:Crystallography, X-Ray; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031109:Periploca / Q000737:chemistry*; D010545:Peroxides / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D006027:Glycosides; D007166:Immunosuppressive Agents; D010545:Peroxides; D010936:Plant Extracts