title: A functional polymorphism in miRNA-196a2 is associated with colorectal cancer risk in a Chinese population.
abstract: Single-nucleotide polymorphisms in microRNAs (miRNAs) may alter miRNA expression levels or processing and, thus, may contribute to cancer development. We hypothesized that miRNA-196a2 polymorphism is associated with risk of colorectal cancer (CRC). In a case-control study of 573 patients with CRC and 588 cancer-free controls frequency matched by age and sex, we genotyped the functional polymorphism rs11614913 (T>C) and assessed its association with the risk of CRC in a Chinese population. We found that the CT/CC genotypes were associated with a significantly increased risk of CRC (odds ratio [OR]=1.44, 95% confidence interval [CI]=1.10-1.88), compared with the TT genotype. Further, the polymorphism was significantly associated with the risk of patients with advanced stage tumor (Dukes C and D) (OR=1.65, 95% CI=1.11-2.46). Our results suggest that the functional polymorphism rs11614913 in miRNA-196a2 is involved in the etiology of CRC and, thus, may be a marker for genetic susceptibility to CRC.
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Lingjun
authors.initials: L
authors.lastname: Zhu
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chu
authors.forename: Dongying
authors.initials: D
authors.lastname: Gu
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.forename: Danni
authors.initials: D
authors.lastname: Shi
authors.forename: Dongyan
authors.initials: D
authors.lastname: Zhong
authors.forename: Na
authors.initials: N
authors.lastname: Tong
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D005828:Genetics, Population; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C542543:MIRN196 microRNA, human; D035683:MicroRNAs