title: [Evaluation of fracture risk in osteoporosis].
abstract: Osteoporotic fractures are associated with excess mortality. Effective treatment options are available, which reduce the risk of vertebral and non-vertebral fractures, but the identification of patients with high fracture risk is problematic. Low bone mineral density (BMD)--the basis for the diagnosis of osteoporosis--is an important, but not the only determinant of fracture risk. Several clinical risk factors are know that operate partially or completely independently of BMD, and affect the fracture risk. These include age, a prior fragility fracture, a parental history of hip fracture, use of corticosteroids, excess alcohol intake, rheumatoid arthritis, and different types of diseases which can cause secondary bone loss. The FRAX® tool integrates the weight of above mentioned clinical risk factors for fracture risk assessment with or without BMD value, and calculates the 10-year absolute risk of hip and major osteoporotic (hip, vertebral, humerus and forearm together) fracture probabilities. Although the use of data is not yet uniform, the FRAX® is a promising opportunity to identify individuals with high fracture risk. The accumulation of experience with FRAX® is going on and it can modify current diagnostic and therapeutic recommendations in Hungary as well.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Belgyógyászati Klinika, Budapest, Korányi S. u. 2/A 1083. szatmik@bel1.sote.hu
authors.forename: Miklós
authors.initials: M
authors.lastname: Szathmári
mesh_terms: D000367:Age Factors; D000465:Algorithms; D015519:Bone Density; D005260:Female; D006620:Hip Fractures / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D006814:Hungary; D008297:Male; D008403:Mass Screening / Q000379:methods; D058866:Osteoporotic Fractures / Q000209:etiology* / Q000517:prevention & control*; D011157:Population Dynamics; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D016103:Spinal Fractures / Q000209:etiology / Q000517:prevention & control; D011795:Surveys and Questionnaires; D006113:United Kingdom