title: Donor kidney adapts to body dimensions of recipient: no influence of donor gender on renal function after transplantation.
abstract: Female kidneys and kidneys from small donors have been suggested to perform worse after kidney transplantation. Here, we evaluate the impact of gender and body dimensions on posttransplantation GFR in living donor transplantation. Two hundred and ninety-three donor-recipient pairs, who were transplanted at our center were evaluated. All pairs had detailed renal function measurement ((125) I-iothalamate and (131) I-hippuran) 4 months predonation in the donor and 2.5 months posttransplantation in donor and recipient. For 88 pairs, 5 years of recipient follow-up was available. Delta GFR was calculated as (recipient GFR-donor single kidney GFR). Recipients of both male and female kidneys had similar renal function at early and long term after transplantation. Male recipients had higher ERPF, ΔGFR and ΔERPF at both time points. Kidneys of donors smaller than their recipient had higher ΔGFR and ΔERPF than kidneys of larger donors at both time points (p < 0.05). In multivariate analysis, ΔGFR was predicted by donor/recipient BSA-ratio together with transplantation related factors (R(2)  0.19), irrespective of donor and recipient gender. In conclusion, in living donor transplantation, female kidneys perform as well as male donor kidneys. Kidneys adapt to the recipient's body size and demands, independent of gender, without detrimental effects in renal function and outcome up to mid-long term.
authors.affiliation: Internal Medicine Division of Nephrology Obstetrics and Gynecology Transplantation Immunology Surgery, University Medical Center Groningen, the Netherlands. h.tent@umcg.nl
authors.forename: H
authors.initials: H
authors.lastname: Tent
authors.forename: A T
authors.initials: AT
authors.lastname: Lely
authors.forename: T J
authors.initials: TJ
authors.lastname: Toering
authors.forename: M R M
authors.initials: MR
authors.lastname: San Giorgi
authors.forename: M
authors.initials: M
authors.lastname: Rook
authors.forename: S P M
authors.initials: SP
authors.lastname: Lems
authors.forename: B G
authors.initials: BG
authors.lastname: Hepkema
authors.forename: H S
authors.initials: HS
authors.lastname: Hofker
authors.forename: R J
authors.initials: RJ
authors.lastname: Ploeg
authors.forename: J J
authors.initials: JJ
authors.lastname: Homan van der Heide
authors.forename: G J
authors.initials: GJ
authors.lastname: Navis
mesh_terms: D000328:Adult; D049628:Body Size; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged