title: MicroRNAs involved in the EGFR/PTEN/AKT pathway in gliomas.
abstract: Gliomas are the most common type of malignant primary brain tumor. Despite advances in surgery, radiation therapy, and chemotherapy, the prognosis of patients with gliomas has not significantly improved. MicroRNAs (miRNAs), a class of non-coding RNAs, 21-25 nucleotides long, negatively regulate the expression of target genes by interacting with specific sites in mRNAs, and play a critical role in the development of gliomas. The EGFR/PTEN/AKT pathway is a promising target for anti-glioma therapy. Recent studies have showed that regulation of the EGFR/PTEN/AKT pathway by miRNAs plays a major role in glioma progression, indicating a novel way to investigate the tumorigenesis, diagnosis, and therapy of gliomas. Here, we focus on recent findings of miRNAs with respect to the EGFR/PTEN/AKT pathway in gliomas.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300, Guangzhou Road, 210029 Nanjing, People's Republic of China.
authors.forename: Yingyi
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiefeng
authors.initials: X
authors.lastname: Wang
authors.forename: Junxia
authors.initials: J
authors.lastname: Zhang
authors.forename: Guan
authors.initials: G
authors.lastname: Sun
authors.forename: Hui
authors.initials: H
authors.lastname: Luo
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Kang
authors.forename: Peiyu
authors.initials: P
authors.lastname: Pu
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: Yongping
authors.initials: Y
authors.lastname: You
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D005910:Glioma / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D035683:MicroRNAs; C512478:EGFR protein, human; D066246:ErbB Receptors; D051057:Proto-Oncogene Proteins c-akt; D051059:PTEN Phosphohydrolase