title: A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population.
abstract: To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, -1316T/G), PTGES (rs7872802, -404A/G), PTGIS (rs5628, Leu256Leu), PTGS1 (rs3842788, Gln41Gln) and PTGS2 (rs5275, 3'UTR). A total of 398 control subjects and 196 stroke patients (79 ICH and 117 IS) were genotyped by direct sequencing. The rs17222919 SNP was associated with ICH in codominant 1 (P=0.008), dominant (P=0.003) and log-additive (P=0.004) models. Allele frequencies of rs17222919 were different between ICH and controls (P=0.007). However, the seven tested SNPs were not associated with clinical phenotypes (NIHSS, MBI and CRPS) in ICH and IS. These results suggest that the promoter SNP rs17222919 of ALOX5AP may be associated with the development of ICH in Korean population.
authors.affiliation: Department of Physical Medicine & Rehabilitation, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Kim
authors.forename: Woo Yong
authors.initials: WY
authors.lastname: Ahn
authors.forename: Dong Kwan
authors.initials: DK
authors.lastname: Kim
authors.forename: Bong Keun
authors.initials: BK
authors.lastname: Choe
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.forename: Dae Jean
authors.initials: DJ
authors.lastname: Jo
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Yong Seol
authors.initials: YS
authors.lastname: Jeong
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Yun
authors.forename: Seung Don
authors.initials: SD
authors.lastname: Yoo
authors.forename: Hee-Sang
authors.initials: HS
authors.lastname: Kim
authors.forename: Hyung Hwan
authors.initials: HH
authors.lastname: Baik
mesh_terms: D058927:5-Lipoxygenase-Activating Proteins / Q000235:genetics*; D000328:Adult; D000368:Aged; D001092:Arachidonate 12-Lipoxygenase / Q000235:genetics; D001094:Arachidonate 5-Lipoxygenase / Q000235:genetics; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000235:genetics*; D051545:Cyclooxygenase 1 / Q000235:genetics; D051546:Cyclooxygenase 2 / Q000235:genetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D000071876:Prostaglandin-E Synthases; D056910:Republic of Korea
chemical_list: D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human; D003577:Cytochrome P-450 Enzyme System; D001092:Arachidonate 12-Lipoxygenase; C476558:ALOX12 protein, human; D001094:Arachidonate 5-Lipoxygenase; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D019746:Intramolecular Oxidoreductases; C000605862:PTGES protein, human; D000071876:Prostaglandin-E Synthases; C472456:PTGIS protein, human