title: Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues.
abstract: A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Tsvelikhovsky
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D010077:Oxazepines; D010165:Palladium / Q000737:chemistry*
chemical_list: D010077:Oxazepines; D001569:Benzodiazepines; D010165:Palladium