title: [Effects of training on plasma content of nitric oxide, endothelin and NO/ET system in rats fed with high methionine diet].
abstract: OBJECTIVE
  To observe the effects of training on plasma content of NO, ET and NO/ET system in rats fed with high methionine diets.
  
  
  METHODS
  Male Wistar rats were randomly divided into normal diet group (CR), high methionine diet group (MR) and high methionine diet plus 90 min swimming group (T+ MR). Rats in MR and T+ MR group were fed with the diet which contained 3%of methionine for eight weeks, but rats in control group were fed with ordinary diet. After breeding for eight weeks homocysteine (Hcy) level, T-NOS, NO and ET were measured.
  
  
  RESULTS
  Plasma homocysteine of MR increased twofold as compared with that of CR,whereas plasma NO/ET of MR descended significantly (P < 0.05), suggesting that hyperhomocysteinemia was induced by the high methionine diet, and plasma NO/ET system was out of balance. Plasma homocysteine content of T+ MR obviously descended, plasma T-NOS, NO and NO/ET ascended obviously (P < 0.05) as compared with that of MR, and the above indicators of group T + MR were not different as compared with that of CR (P > 0.05).
  
  
  CONCLUSIONS
  Proper training can descend plasma homocysteine level of rats fed with high methionine diet and better balance between NO and ET to prevent developing of hyperhomocysteinemia.
authors.affiliation: Environmental and Public School, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Ren
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Yu
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D016232:Endothelins / Q000097:blood*; D020138:Hyperhomocysteinemia / Q000517:prevention & control; D008297:Male; D008715:Methionine / Q000008:administration & dosage*; D009569:Nitric Oxide / Q000097:blood*; D019001:Nitric Oxide Synthase / Q000097:blood; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000502:physiology
chemical_list: D016232:Endothelins; D009569:Nitric Oxide; D008715:Methionine; D019001:Nitric Oxide Synthase