title: Immune correlates of HIV control.
abstract: The development of an effective HIV vaccine is still hampered by the lack of clearly defined immune correlates of HIV control. Although a number of immune markers have been associated over last years with relative viral control and slower HIV disease progression, these associations are oftentimes complicated by the causality dilemma that does not allow to directly assign cause or effect to the identified parameters. In addition, many of these immune markers may act in concert or represent surrogate makers for otherwise controlled HIV infection. This review will revisit the current knowledge of host genetic and immune markers and their associations with HIV control, particularly examining the roles of virus-specific T cells and humoral immune responses and testing their role as direct correlates of control.
authors.affiliation: AIDS Research Institute IrsiCaixa - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Spain.
authors.forename: J G
authors.initials: JG
authors.lastname: Prado
authors.forename: J
authors.initials: J
authors.lastname: Carrillo
authors.forename: J
authors.initials: J
authors.lastname: Blanco-Heredia
authors.forename: C
authors.initials: C
authors.lastname: Brander
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology* / Q000627:therapeutic use; D015658:HIV Infections / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control*; D006679:HIV Seropositivity / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral / Q000502:physiology
chemical_list: D016915:AIDS Vaccines