title: Transfusion-related acute lung injury in a neutropenic patient.
abstract: Transfusion-related acute lung injury (TRALI) is a leading cause of transfusion related morbidity and mortality. Current concepts regarding the pathogenesis of this disorder imply a "two-hit" model in which neutrophils are sequestered in the pulmonary capillary bed, and subsequently activated by substances in the transfused blood product. We report a case of TRALI in a patient with neutropenia and discuss the possible factors contributing to the respiratory symptoms in this patient. We also emphasise the importance of recognising mild cases of TRALI in order to investigate the implicated donor/s appropriately, and to minimise the risk for more severe episodes in other patients.
authors.affiliation: Department of Haematology, PathWest Laboratory Medicine, QEII Medical Centre, Western Australia, Australia. jill.finlayson@health.wa.gov.au
authors.forename: J
authors.initials: J
authors.lastname: Finlayson
authors.forename: D
authors.initials: D
authors.lastname: Grey
authors.forename: L
authors.initials: L
authors.lastname: Kavanagh
authors.forename: C
authors.initials: C
authors.lastname: Witt
mesh_terms: D055371:Acute Lung Injury / Q000175:diagnosis* / Q000209:etiology; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000150:complications / Q000175:diagnosis*; D017713:Platelet Transfusion / Q000009:adverse effects*; D014019:Tissue Donors