title: Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma.
abstract: Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, metastasis at recurrence, and death compared with Group B patients. Identification and optimization of immunohistochemical (IHC) markers for PF ependymoma subgroups allowed validation of our findings on a third independent cohort, using a human ependymoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients.
authors.affiliation: Division Molecular Genetics, German Cancer Research Center, 69120 Heidelberg, Germany.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Witt
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Mack
authors.forename: Marina
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authors.lastname: Ryzhova
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bender
authors.forename: Martin
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authors.lastname: Sill
authors.forename: Ruth
authors.initials: R
authors.lastname: Isserlin
authors.forename: Axel
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authors.lastname: Benner
authors.forename: Thomas
authors.initials: T
authors.lastname: Hielscher
authors.forename: Till
authors.initials: T
authors.lastname: Milde
authors.forename: Marc
authors.initials: M
authors.lastname: Remke
authors.forename: David T W
authors.initials: DT
authors.lastname: Jones
authors.forename: Paul A
authors.initials: PA
authors.lastname: Northcott
authors.forename: Livia
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authors.lastname: Garzia
authors.forename: Kelsey C
authors.initials: KC
authors.lastname: Bertrand
authors.forename: Andrea
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authors.lastname: Wittmann
authors.forename: Yuan
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authors.lastname: Yao
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Roberts
authors.forename: Luca
authors.initials: L
authors.lastname: Massimi
authors.forename: Tim
authors.initials: T
authors.lastname: Van Meter
authors.forename: William A
authors.initials: WA
authors.lastname: Weiss
authors.forename: Nalin
authors.initials: N
authors.lastname: Gupta
authors.forename: Wiesia
authors.initials: W
authors.lastname: Grajkowska
authors.forename: Boleslaw
authors.initials: B
authors.lastname: Lach
authors.forename: Yoon-Jae
authors.initials: YJ
authors.lastname: Cho
authors.forename: Andreas
authors.initials: A
authors.lastname: von Deimling
authors.forename: Andreas E
authors.initials: AE
authors.lastname: Kulozik
authors.forename: Olaf
authors.initials: O
authors.lastname: Witt
authors.forename: Gary D
authors.initials: GD
authors.lastname: Bader
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Hawkins
authors.forename: Uri
authors.initials: U
authors.lastname: Tabori
authors.forename: Abhijit
authors.initials: A
authors.lastname: Guha
authors.forename: James T
authors.initials: JT
authors.lastname: Rutka
authors.forename: Peter
authors.initials: P
authors.lastname: Lichter
authors.forename: Andrey
authors.initials: A
authors.lastname: Korshunov
authors.forename: Michael D
authors.initials: MD
authors.lastname: Taylor
authors.forename: Stefan M
authors.initials: SM
authors.lastname: Pfister
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000145:classification* / Q000235:genetics; D002869:Chromosome Aberrations; D003388:Cranial Fossa, Posterior / Q000473:pathology*; D004806:Ependymoma / Q000145:classification* / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008875:Middle Aged