title: Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder.
abstract: Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
authors.affiliation: Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.
authors.forename: Yaoting
authors.initials: Y
authors.lastname: Gui
authors.forename: Guangwu
authors.initials: G
authors.lastname: Guo
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Xueda
authors.initials: X
authors.lastname: Hu
authors.forename: Aifa
authors.initials: A
authors.lastname: Tang
authors.forename: Shengjie
authors.initials: S
authors.lastname: Gao
authors.forename: Renhua
authors.initials: R
authors.lastname: Wu
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Xianxin
authors.initials: X
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Minghui
authors.initials: M
authors.lastname: He
authors.forename: Zesong
authors.initials: Z
authors.lastname: Li
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Sun
authors.forename: Wenlong
authors.initials: W
authors.lastname: Jia
authors.forename: Jinnong
authors.initials: J
authors.lastname: Chen
authors.forename: Shangming
authors.initials: S
authors.lastname: Yang
authors.forename: Fangjian
authors.initials: F
authors.lastname: Zhou
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Zhao
authors.forename: Shengqing
authors.initials: S
authors.lastname: Wan
authors.forename: Rui
authors.initials: R
authors.lastname: Ye
authors.forename: Chaozhao
authors.initials: C
authors.lastname: Liang
authors.forename: Zhisheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Peide
authors.initials: P
authors.lastname: Huang
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Hancheng
authors.initials: H
authors.lastname: Zheng
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.forename: Xingwang
authors.initials: X
authors.lastname: Liu
authors.forename: Zhimao
authors.initials: Z
authors.lastname: Jiang
authors.forename: Dafei
authors.initials: D
authors.lastname: Feng
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Song
authors.initials: S
authors.lastname: Wu
authors.forename: Jing
authors.initials: J
authors.lastname: Zou
authors.forename: Zhongfu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Ruilin
authors.initials: R
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Congjie
authors.initials: C
authors.lastname: Xu
authors.forename: Weihua
authors.initials: W
authors.lastname: Yin
authors.forename: Zhichen
authors.initials: Z
authors.lastname: Guan
authors.forename: Jiongxian
authors.initials: J
authors.lastname: Ye
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Jingxiang
authors.initials: J
authors.lastname: Li
authors.forename: Karsten
authors.initials: K
authors.lastname: Kristiansen
authors.forename: Michael L
authors.initials: ML
authors.lastname: Nickerson
authors.forename: Dan
authors.initials: D
authors.lastname: Theodorescu
authors.forename: Yingrui
authors.initials: Y
authors.lastname: Li
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Zhang
authors.forename: Songgang
authors.initials: S
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Huanming
authors.initials: H
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Cai
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D002869:Chromosome Aberrations; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009154:Mutation; D001749:Urinary Bladder Neoplasms / Q000235:genetics*