title: Sedentary behaviors and emerging cardiometabolic biomarkers in adolescents.
abstract: OBJECTIVE
  To examine the associations of objectively measured sedentary time and television (TV) viewing time with emerging inflammatory and endothelial function markers in adolescents.
  
  
  METHODS
  This study comprised 183 adolescents (88 girls), aged 13 to 17 years. Sedentary time and moderate-to-vigorous physical activity was objectively measured with accelerometry, whereas TV viewing time was self-reported. White blood cell counts and levels of C-reactive protein, complement factors C3 and C4, interleukin-6, adiponectin, leptin, intercellular adhesion molecule 1, vascular cell adhesion molecule 1, E-selectin, L-selectin, and plasminogen activator inhibitor-1 were measured in fasted blood samples.
  
  
  RESULTS
  Sedentary time was not significantly associated with any of the examined cardiometabolic markers after controlling for potential confounders. However, TV viewing time was positively associated with soluble endothelial adhesion molecules intercellular adhesion molecule 1 (standardized β = 0.19, P = .008), vascular cell adhesion molecule 1 (β = 0.17, P = .020), L-selectin (β = 0.18, P = .013), and E-selectin (β = 0.16, P = .023) concentrations, after controlling for sex, age, pubertal status, moderate-to-vigorous physical activity, body mass index, and total sedentary time.
  
  
  CONCLUSIONS
  High TV viewing time may play a key role in cardiovascular and metabolic diseases through the cell adhesion molecules in adolescence.
authors.affiliation: Department of Metabolism and Nutrition, Spanish National Research Council, Madrid, Spain. d.martinez@uam.es
authors.forename: David
authors.initials: D
authors.lastname: Martinez-Gomez
authors.forename: Joey C
authors.initials: JC
authors.lastname: Eisenmann
authors.forename: Genevieve N
authors.initials: GN
authors.lastname: Healy
authors.forename: Sonia
authors.initials: S
authors.lastname: Gomez-Martinez
authors.forename: L Esperanza
authors.initials: LE
authors.lastname: Diaz
authors.forename: David W
authors.initials: DW
authors.lastname: Dunstan
authors.forename: Oscar L
authors.initials: OL
authors.lastname: Veiga
authors.forename: Ascension
authors.initials: A
authors.lastname: Marcos
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000097:blood*; D057185:Sedentary Behavior; D013690:Television / Q000706:statistics & numerical data; D013997:Time Factors
chemical_list: D015415:Biomarkers