title: Factors associated with recurrence and therapeutic strategies for sinonasal Rosai-Dorfman disease.
abstract: BACKGROUND
  The purpose of this study was to explore the factors associated with the recurrence of Rosai-Dorfman disease (RDD) in the nasal cavity and paranasal sinus.
  
  
  METHODS
  In this study, we conducted a review of the English-language literature published between 1969 and 2010 on the recurrence of and treatment strategies for sinonasal RDD.
  
  
  RESULTS
  To our knowledge, 126 cases of RDD have been reported to date. Of the 126 patients, 32 (25.4%) had no recurrence or were alive with no evidence of disease; remission occurred in only 1 patient (0.7%); 69 patients (54.8%) had a recurrent, persistent, or progressive course; and 6 patients (4.8%) died from the disease. In patients with recurrent, persistent, and progressive disease, there was no significant tendency for lymph node involvement.
  
  
  CONCLUSIONS
  Sinonasal RDD is generally described as benign. However, recurrence and fatal outcome have been reported. Our results suggest that the initial modality may affect the recurrence of RDD.
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors.forename: Hai-Hong
authors.initials: HH
authors.lastname: Chen
authors.forename: Shui-Hong
authors.initials: SH
authors.lastname: Zhou
authors.forename: Shen-Qing
authors.initials: SQ
authors.lastname: Wang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Teng
authors.forename: Jun
authors.initials: J
authors.lastname: Fan
mesh_terms: D001707:Biopsy, Needle; D004724:Endoscopy / Q000009:adverse effects / Q000379:methods*; D005500:Follow-Up Studies; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009296:Nasal Cavity / Q000473:pathology* / Q000601:surgery; D010254:Paranasal Sinus Diseases / Q000473:pathology* / Q000601:surgery; D012008:Recurrence; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult