title: Common and distinct neural correlates of emotional processing in Bipolar Disorder and Major Depressive Disorder: a voxel-based meta-analysis of functional magnetic resonance imaging studies.
abstract: Neuroimaging studies have consistently shown functional brain abnormalities in patients with Bipolar Disorder (BD) and Major Depressive Disorder (MDD). However, the extent to which these two disorders are associated with similar or distinct neural changes remains unclear. We conducted a systematic review of functional magnetic resonance imaging studies comparing BD and MDD patients to healthy participants using facial affect processing paradigms. Relevant spatial coordinates from twenty original studies were subjected to quantitative Activation Likelihood Estimation meta-analyses based on 168 BD and 189 MDD patients and 344 healthy controls. We identified common and distinct patterns of neural engagement for BD and MDD within the facial affect processing network. Both disorders were associated with increased engagement of limbic regions. Diagnosis-specific differences were observed in cortical, thalamic and striatal regions. Decreased ventrolateral prefrontal cortical engagement was associated with BD while relative hypoactivation of the sensorimotor cortices was seen in MDD. Increased responsiveness in the thalamus and basal ganglia were associated with BD. These findings were modulated by stimulus valence. These data suggest that whereas limbic overactivation is reported consistently in patients with mood disorders, future research should consider the relevance of a wider network of regions in formulating conceptual models of BD and MDD.
authors.affiliation: European College of Neuropsychopharmacology, Networks Initiative, Neuroimaging Network, London, UK.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Delvecchio
authors.forename: Philippe
authors.initials: P
authors.lastname: Fossati
authors.forename: Patrice
authors.initials: P
authors.lastname: Boyer
authors.forename: Paolo
authors.initials: P
authors.lastname: Brambilla
authors.forename: Peter
authors.initials: P
authors.lastname: Falkai
authors.forename: Oliver
authors.initials: O
authors.lastname: Gruber
authors.forename: Jarmo
authors.initials: J
authors.lastname: Hietala
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Lawrie
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Martinot
authors.forename: Andrew M
authors.initials: AM
authors.lastname: McIntosh
authors.forename: Eva
authors.initials: E
authors.lastname: Meisenzahl
authors.forename: Sophia
authors.initials: S
authors.lastname: Frangou
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000098:blood supply / Q000473:pathology; D001931:Brain Mapping; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D003865:Major Depressive Disorder / Q000473:pathology*; D004644:Emotions; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen