title: Cervical intraepithelial neoplasia and invasive cancer risks in women infected with HIV in the French West Indies.
abstract: OBJECTIVE
  The aim of the study was to assess whether HIV infection is associated with a higher risk of invasive cervical cancer (ICC).
  
  
  METHODS
  We conducted a region-wide, population-based observational cohort study of 1232 HIV-infected women over the age of 15 years in Guadeloupe, a French Caribbean archipelago, during the period 1999-2006. The observed numbers of incident cases of cervical intraepithelial neoplasia (CIN) and ICC were compared with the expected numbers of cases based on the incidence rates for the general population, and the standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated.
  
  
  RESULTS
  The incidence rate of CIN was higher in the HIV-infected women than in the general population for all grades (SIR 10.1, 95% CI 6.8-14.6 for CIN grade 1; SIR 9.9, 95% CI 6.1-15.3 for CIN grade 2; and SIR 5.2, 95% CI 3.4-7.7 for CIN grade 3). However, no increase in the risk of ICC was observed (SIR 1.7, 95% CI 0.3-4.9).
  
  
  CONCLUSIONS
  Despite an increase in the occurrence of cervical cancer precursors, no increase in the risk of cervical cancer was found in a population of HIV-infected women who receive treatment for their infection and have access to ICC prevention services.
authors.affiliation: Parent-Child Department, Gynecology and Obstetrics Unit, Pointe-à-Pitre/Abymes University Hospital Center, Pointe-à-Pitre Cedex, France. philippe.kadhel@orange.fr
authors.forename: P
authors.initials: P
authors.lastname: Kadhel
authors.forename: L
authors.initials: L
authors.lastname: Multigner
authors.forename: F
authors.initials: F
authors.lastname: Bardinet
authors.forename: Mt
authors.initials: M
authors.lastname: Goerger-Sow
authors.forename: E
authors.initials: E
authors.lastname: Janky
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019430:Guadeloupe / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011446:Prospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000453:epidemiology*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000453:epidemiology*