title: [Components of myrsinane-type diterpenes from Euphorbia prolifera].
abstract: To extract and isolate the component from myrsinane-type diterpenes of Euphorbia prolifera.
  
  
  
  Petroleum extraction and chromatography on the silica gel were used to extract and isolate the diterpenes of Euphorbia prolifera.
  
  
  
  Eight components of myrsinol diterpenes were isolated, namely: Proliferin A(1), Proliferin B (2), Proliferin C(3), Proliferin D(4), Euphorprolitherin B(5), Euphorprolitherin D(6), SPr5(7) and 14-desoxo-3-O-prorionyl-5, 15-di-O-acetyl-7-O-nicotinoyl-myrsinol-14β-acetate(8). Their structures were identified with mass-spectroscopic methods and NMR techniques. The cytotoxicity of compounds 1, 2, and 4 against cancer cells was evaluated, with compound 1 being active against A2780 cancer cells (IC(50) 7.7 μmol/L).
  
  
  
  Myrsinane-type diterpene Proliferin A from Euphorbia prolifera shows cytotoxic effect against human ovarian cancer cell line A2780.
authors.affiliation: School of Medicine and Life Sciences, Zhejiang University City College, Hangzhou 310015, China. lijie@zucc.edu.cn
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Liang
authors.initials: L
authors.lastname: Deng
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C562259:proliferin A