title: An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy.
abstract: By rationally employing enzymes for signal amplification, an ultrasensitive aptasensor was developed and successfully tested in a system designed to detect lysozyme with a detection limit of 0.1 fM. This detection limit is nearly three orders of magnitude lower than those of any previously reported DNAzyme-based aptasensors.
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK21 Program), KAIST, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Rongzhan
authors.initials: R
authors.lastname: Fu
authors.forename: Kyungeun
authors.initials: K
authors.lastname: Jeon
authors.forename: Cheulhee
authors.initials: C
authors.lastname: Jung
authors.forename: Hyun Gyu
authors.initials: HG
authors.lastname: Park
mesh_terms: D052157:Aptamers, Nucleotide / Q000378:metabolism*; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000378:metabolism; D021881:DNA, Catalytic / Q000378:metabolism*; D006735:Horseradish Peroxidase / Q000378:metabolism*; D057230:Limit of Detection; D009113:Muramidase / Q000032:analysis / Q000378:metabolism
chemical_list: D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D004247:DNA; D006735:Horseradish Peroxidase; D009113:Muramidase