title: Association of FCGR2A, JAK2 or HNF4A variants with ulcerative colitis in Koreans.
abstract: BACKGROUND
  Recent genome-wide association studies have identified over 40 candidate genes contributing to ulcerative colitis susceptibility. The goal of this study was to test the reported ulcerative colitis susceptibility genes including FCGR2A, SLC26A3, JAK2 and HNF4A in Korean patients with ulcerative colitis and Crohn's disease.
  
  
  METHODS
  Five single nucleotide polymorphisms from 4 loci including FCGR2A, SLC26A3, JAK2 and HNF4A were genotyped in 661 patients with ulcerative colitis, 642 patients with Crohn's disease and 601 healthy controls.
  
  
  RESULTS
  Statistically significant associations with ulcerative colitis were found at FCGR2A (rs1801274, p=2.3×10(-4), OR=0.70 (95% CI=0.57-0.84) under the allelic model), the JAK2 locus (rs10975003, p=6.7×10(-4), OR=1.43 (95% CI=1.16-1.77) under the allelic model) and HNF4A (rs6017342, p=0.002, OR=0.66 (95% CI=0.51-0.85) under the allelic model). The association of FCGR2A was much stronger in female patients with ulcerative colitis (p=5.7×10(-6)) than in males (p=0.50). Except rs10975003 from the JAK2 locus, none showed positive association with Crohn's disease.
  
  
  CONCLUSIONS
  Our data suggest that FCGR2A, JAK2 or HNF4A variants play a role in the pathogenesis of ulcerative colitis in Koreans.
authors.affiliation: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Suk-Kyun
authors.initials: SK
authors.lastname: Yang
authors.forename: Yusun
authors.initials: Y
authors.lastname: Jung
authors.forename: Hyeri
authors.initials: H
authors.lastname: Kim
authors.forename: Myunghee
authors.initials: M
authors.lastname: Hong
authors.forename: Byong Duk
authors.initials: BD
authors.lastname: Ye
authors.forename: Kyuyoung
authors.initials: K
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D027963:Chloride-Bicarbonate Antiporters / Q000235:genetics; D003093:Colitis, Ulcerative / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051557:Hepatocyte Nuclear Factor 4 / Q000235:genetics; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics; D056910:Republic of Korea; D012737:Sex Factors; D000076988:Sulfate Transporters; D055815:Young Adult
chemical_list: D027963:Chloride-Bicarbonate Antiporters; C445323:FCGR2A protein, human; C496592:HNF4A protein, human; D051557:Hepatocyte Nuclear Factor 4; D017452:Receptors, IgG; C081011:SLC26A3 protein, human; D000076988:Sulfate Transporters; C507924:JAK2 protein, human; D053614:Janus Kinase 2