title: Detecting cognitive impairment in individuals at risk for cardiovascular disease: the "Clock-in-the-Box" screening test.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the performance on the Clock-in-the-Box (CIB), a screening measure for cognitive function, relative to neuropsychological testing in an older population with cardiovascular risk.
  
  
  METHODS
  A prospective cohort of older patients (>50 years) with cardiovascular risk was recruited to perform the CIB and complete a brief neuropsychological battery consisting of Trailmaking tests, the Hopkins Verbal Learning Test (HVLT), and fluency tasks. Performance on the CIB was scored according to standard criteria (range 0-8, 0-worst). The performance on the total CIB, working memory subscale (CIB-WM), and planning/organization (COB-PO) was compared to neuropsychological measures.
  
  
  RESULTS
  The cohort (n = 127) was older (age 67 ± 7 years) and diverse with 33% female (n = 42) and 42% non-white race (n = 53). Cardiac risk factors were prevalent: hypertension (83%), hyperlipidemia (74%), overweight (84%), diabetes (48%), prior cardiac disease (39%), and smoking (11%). The CIB (mean 6.5 ± 1.3) took 84 ± 21 s on average to complete and had good inter-rater reliability (κ = 0.809, p < 0.01). The CIB-WM subscale was significantly correlated with performance on Trailmaking B and HVLT learning, recall, and recognition. The CIB-PO subscale was significantly associated with semantic and phonemic fluency, Trailmaking B, and HVLT learning and recall. In regression modeling, CIB-WM significantly predicted performance on HVLT learning, recall, and retention. CIB-PO subscale predicted performance on Trailmaking B, HVLT learning, and HVLT recall.
  
  
  CONCLUSIONS
  The CIB is a brief cognitive screening instrument with good reliability and predictive validity in a CV risk population. The CIB-WM and CIB-PO subscales could provide utility for clinicians.
authors.affiliation: Geriatric Research Education and Clinical Center, Boston VA Healthcare System, Boston, MA, USA.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Grande
authors.forename: James L
authors.initials: JL
authors.lastname: Rudolph
authors.forename: William P
authors.initials: WP
authors.lastname: Milberg
authors.forename: Colleen E
authors.initials: CE
authors.lastname: Barber
authors.forename: Regina E
authors.initials: RE
authors.lastname: McGlinchey
mesh_terms: D000368:Aged; D010054:Brief Psychiatric Rating Scale / Q000592:standards*; D002318:Cardiovascular Diseases / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008570:Memory, Short-Term; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012307:Risk Factors; D014706:Verbal Learning / Q000502:physiology