title: Acute pulmonary histoplasmosis in a patient with uveitis after infliximab therapy.
abstract: The purpose of this study is to report a case of disseminated histoplasmosis in a patient with uveitis, after treatment with infliximab. The method employed in this study is single case report. Infliximab can be useful in controlling idiopathic uveitis, but can give rise to disseminated histoplamosis, especially in patients living in geographic areas where histoplasmosis is endemic. Clinicians should be aware of the possibility of rapid onset histoplasmosis in patients receiving anti-tumor necrosis factor agents. In such cases, these agents should be immediately stopped, investigations performed, and appropriate treatment started.
authors.affiliation: Tennent Institute of Ophthalmology, Gartnavel General Hospital, 1053 Great Western Road, Glasgow, G12 0YN, UK. likthai@doctors.org.uk
authors.forename: Lik Thai
authors.initials: LT
authors.lastname: Lim
authors.forename: Nargiz
authors.initials: N
authors.lastname: Ruzmetova
authors.forename: Susan H
authors.initials: SH
authors.lastname: Ballinger
authors.forename: Ramana S
authors.initials: RS
authors.lastname: Moorthy
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006658:Histoplasma / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D000069285:Infliximab; D008168:Lung / Q000382:microbiology*; D008297:Male; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014605:Uveitis / Q000188:drug therapy*; D014606:Uveitis, Anterior / Q000150:complications / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab