title: Molecular diagnosis of lobomycosis-like disease in a bottlenose dolphin in captivity.
abstract: We report the diagnosis and molecular characterization of lobomycosis-like lesions in a captive bottlenose dolphin. The clinical picture and the absence of growth in conventional media resembled the features associated with Lacazia loboi. However sequencing of ribosomal DNA and further phylogenetic analyses showed a novel sequence more related to Paracoccidioides brasilensis than to L. loboi. Moreover, the morphology of the yeast cells differed from those L. loboi causing infections humans. These facts suggest that the dolphin lobomycosis-like lesions might have been be caused by different a different fungus clustered inside the order Onygenales. A successful treatment protocol based on topic and systemic terbinafine is also detailed.
authors.affiliation: Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain. esperon@inia.es
authors.forename: Fernando
authors.initials: F
authors.lastname: Esperón
authors.forename: Daniel
authors.initials: D
authors.lastname: García-Párraga
authors.forename: Edwige Nina
authors.initials: EN
authors.lastname: Bellière
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Sánchez-Vizcaíno
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D050681:Bottle-Nosed Dolphin; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D060368:Lobomycosis / Q000473:pathology / Q000662:veterinary; D008969:Molecular Sequence Data; D010228:Paracoccidioides / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D010229:Paracoccidioidomycosis / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D017422:Sequence Analysis, DNA
chemical_list: D004271:DNA, Fungal