title: A case series and review of sporotrichosis in Sikkim.
abstract: Sporotrichosis caused by the fungus Sporothrix schenckii has been widely reported from the northern Himalayan belt and the north eastern region of India. Three autochthonous cases of lymphocutaneous sporotrichosis from east and south districts of Sikkim are reported. Fluid aspirate from the nodulo-ulcerative lesions were sent for cytology and fungal culture. S. schenckii was isolated on culture and cytological examination in all three cases showed granulomatous reaction. Thermal dimorphism was demonstrated and animal pathogenicity testing was performed. Saturated solution of potassium iodide was used for treatment and the last case was treated with itraconazole and potassium iodide. Awareness of this disease and an extensive environmental study is required to understand the actual burden of this disease.
authors.affiliation: Department of Microbiology, Sir Thotub Namgyal Memorial Hospital, Gangtok, Sikkim, India. pemla55@yahoo.co.in
authors.forename: Pema Yoden
authors.initials: PY
authors.lastname: Bhutia
authors.forename: Shrijana
authors.initials: S
authors.lastname: Gurung
authors.forename: Prakash Peralam
authors.initials: PP
authors.lastname: Yegneswaran
authors.forename: Jagat
authors.initials: J
authors.lastname: Pradhan
authors.forename: Uttam
authors.initials: U
authors.lastname: Pradhan
authors.forename: Tshering
authors.initials: T
authors.lastname: Peggy
authors.forename: Prakash Kumar
authors.initials: PK
authors.lastname: Pradhan
authors.forename: Chewang Doma
authors.initials: CD
authors.lastname: Bhutia
mesh_terms: D000328:Adult; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D003881:Dermatomycoses / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008206:Lymphatic Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D008297:Male; D051379:Mice; D008875:Middle Aged; D011193:Potassium Iodide / Q000627:therapeutic use; D012819:Sikkim / Q000453:epidemiology; D013175:Sporothrix / Q000302:isolation & purification* / Q000472:pathogenicity; D013174:Sporotrichosis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D011193:Potassium Iodide; D017964:Itraconazole