title: Application of platelet-rich plasma for enhanced bone regeneration in grafted sinus.
abstract: OBJECTIVE
  The present study was conducted to evaluate the effect of platelet-rich plasma (PRP) on new bone formation and remodeling after grafting of the maxillary sinus with an algae-derived hydroxyapatite AlgOss/C Graft/Algipore.
  
  
  METHODS
  Fourteen consecutive patients with severely atrophic maxillae underwent uni- or bilateral grafting of the maxillary sinus with a mixture of collected bone, algae-derived hydroxyapatite AlgOss/C Graft/Algipore (ratio 1:10), and a combined addition of PRP and thrombin (Tissucol Kit; Baxter, Vienna, Austria) to allow for fast clotting. After an average healing period of 7.1 months bone samples were retrieved. Patients from a former consecutive series treated without PRP served as control group. Statistical analysis was done by Welch 2-sample t test and mixed linear model testing.
  
  
  RESULTS
  In the coronal specimen portions, mean values for newly formed bone area, biomaterial area and marrow space of 32.2% ± 10.4%, 20.1% ± 13.0%, and 47.7% ± 8.5% were found with PRP, respectively. In the control group the corresponding values were 27.6% ± 13.4%, 20.3% ± 12.9%, and 52.1% ± 9.3%. In the apical specimen portions in the PRP group, the newly formed bone area, biomaterial area, and marrow space was 25.7% ± 15.0%, 23.4% ± 14.9%, and 50.9% ± 12.5%, respectively. The corresponding values in the control group were 17.0% ± 8.6%, 34.5% ± 11.2%, and 48.5% ± 8.5%.
  
  
  CONCLUSIONS
  Statistical evaluation of the samples proved significantly better overall resorption of algae-derived hydroxyapatite AlgOss/C Graft/Algipore and increased new bone formation when PRP was used, especially in the apical region.
authors.affiliation: Department of Craniomaxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Poeschl
authors.forename: Farzad
authors.initials: F
authors.lastname: Ziya-Ghazvini
authors.forename: Kurt
authors.initials: K
authors.lastname: Schicho
authors.forename: Christoph
authors.initials: C
authors.lastname: Buchta
authors.forename: Doris
authors.initials: D
authors.lastname: Moser
authors.forename: Rudolf
authors.initials: R
authors.lastname: Seemann
authors.forename: Rolf
authors.initials: R
authors.lastname: Ewers
authors.forename: Christian
authors.initials: C
authors.lastname: Schopper
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016301:Alveolar Bone Loss / Q000601:surgery*; D000540:Alveolar Ridge Augmentation / Q000379:methods; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008437:Maxilla / Q000601:surgery; D008443:Maxillary Sinus; D008875:Middle Aged; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods; D016348:Osseointegration / Q000187:drug effects*; D053657:Platelet-Rich Plasma; D059546:Sinus Floor Augmentation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: C483718:Algipore; D018786:Bone Substitutes