title: New insights into HIV assembly and trafficking.
abstract: Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly translocates to membrane to orchestrate particle production. The cell biology of HIV-1 Gag trafficking is currently one of the least understood aspects of HIV-1 replication. In this review, we highlight the current understanding of the cellular machinery involved in Gag trafficking and virus assembly.
authors.affiliation: Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA.
authors.forename: Muthukumar
authors.initials: M
authors.lastname: Balasubramaniam
authors.forename: Eric O
authors.initials: EO
authors.lastname: Freed
mesh_terms: D015497:HIV-1 / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D021381:Protein Transport; D019065:Virus Assembly / Q000502:physiology*; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000378:metabolism
chemical_list: D054301:gag Gene Products, Human Immunodeficiency Virus