title: Antibiotics and the post-genome revolution.
abstract: The emergence of pathogenic bacteria resistant to multiple antimicrobial agents is turning into a major crisis in human and veterinary medicine. This necessitates a serious re-evaluation of our approaches toward antibacterial drug discovery and use. Concurrent advances in genomics including whole-genome sequencing, genotyping, and gene expression profiling have the potential to transform our basic understanding of antimicrobial pathways and lead to the discovery of novel targets and therapeutics.
authors.affiliation: Department of Molecular Biology & Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, United States.
authors.forename: Sasan
authors.initials: S
authors.lastname: Amini
authors.forename: Saeed
authors.initials: S
authors.lastname: Tavazoie
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics*; D055808:Drug Discovery / Q000379:methods*; D016680:Genome, Bacterial; D023281:Genomics / Q000379:methods*; D005838:Genotype; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics; D059467:Transcriptome
chemical_list: D000900:Anti-Bacterial Agents