title: Diffuse large B-cell lymphoma with aberrant expression of the T-cell antigens CD2 and CD7.
abstract: Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma. Although, aberrant expression of a single T-cell-associated antigen (exclusive of CD5) on diffuse large B-cell lymphoma has occasionally been described in the literature, cases that show coexpression of ≥2 T-cell antigens on a well-documented case of diffuse large B-cell lymphoma are extremely rare. Here, we describe a well-characterized case of diffuse large B-cell lymphoma that showed aberrant coexpression of 2 T-cell-associated antigens, CD2 and CD7. Recognition of these types of cases is important to help ensure accurate diagnoses are made.
authors.affiliation: Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA. nikhil_sangle@yahoo.com
authors.forename: Nikhil A
authors.initials: NA
authors.lastname: Sangle
authors.forename: Archana M
authors.initials: AM
authors.lastname: Agarwal
authors.forename: Kristi J
authors.initials: KJ
authors.lastname: Smock
authors.forename: Matthew O
authors.initials: MO
authors.lastname: Leavitt
authors.forename: Roger
authors.initials: R
authors.lastname: Warnke
authors.forename: David
authors.initials: D
authors.lastname: Bahler
authors.forename: Sherrie L
authors.initials: SL
authors.lastname: Perkins
mesh_terms: D019011:Antigens, CD7 / Q000378:metabolism; D001402:B-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D018801:CD2 Antigens / Q000378:metabolism; D002469:Cell Separation; D003937:Diagnosis, Differential; D005221:Fatigue; D005260:Female; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016130:Immunophenotyping; D008206:Lymphatic Diseases; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009367:Neoplasm Staging; D012074:Remission Induction; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D019011:Antigens, CD7; D014408:Biomarkers, Tumor; D018801:CD2 Antigens