title: Design and characterization of bi-soft segmented polyurethane microparticles for biomedical application.
abstract: Bi-soft segmented poly(ester urethane urea) microparticles were prepared and characterized aiming a biomedical application. Two different formulations were developed, using poly(propylene glycol), tolylene 2,4-diisocyanate terminated pre-polymer (TDI) and poly(propylene oxide)-based tri-isocyanated terminated pre-polymer (TI). A second soft segment was included due to poly(ɛ-caprolactone) diol (PCL). Infrared spectroscopy, used to study the polymeric structure, namely its H-bonding properties, revealed a slightly higher degree of phase separation in TDI-microparticles. TI-microparticles presented slower rate of hydrolytic degradation, and, accordingly, fairly low toxic effect against macrophages. These new formulations are good candidates as non-biodegradable biomedical systems.
authors.affiliation: Research Centre for Chemical Processes Engineering and Forest Products (CIEPQPF), Department of Chemical Engineering, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal. elisajcampos@gmail.com
authors.forename: Elisa
authors.initials: E
authors.lastname: Campos
authors.forename: Rosemeyre
authors.initials: R
authors.lastname: Cordeiro
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Santos
authors.forename: Cláudia
authors.initials: C
authors.lastname: Matos
authors.forename: M H
authors.initials: MH
authors.lastname: Gil
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002478:Cells, Cultured; D051379:Mice; D008807:Mice, Inbred BALB C; D008853:Microscopy; D011108:Polymers / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011140:Polyurethanes; D011409:Propylene Glycols; C012504:polypropylene glycol