title: Cytotoxicity of chemical constituents from the stems of Dalbergia parviflora.
abstract: Three new compounds, dalberpene, dalparvinene B and dalparvone B, as well as 12 known compounds were isolated from the heartwood of Dalbergia parviflora. Isoflavanone 13 showed strong cytotoxicity against KB, MCF-7 and NCI-H187 cell lines with IC₅₀ values ranging from 3.5 to 5.4μg/mL and it was inactive against normal cells.
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Uraiwan
authors.initials: U
authors.lastname: Songsiang
authors.forename: Chariya
authors.initials: C
authors.lastname: Hahnvajanawong
authors.forename: Chavi
authors.initials: C
authors.lastname: Yenjai
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002460:Cell Line; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D002934:Cinnamates / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D035782:Dalbergia / Q000737:chemistry*; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018547:Plant Stems; D014709:Vero Cells; D014934:Wood
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002934:Cinnamates; D005663:Furans; D007529:Isoflavones; D010936:Plant Extracts; C571562:dalberpene; C571565:dalparvinene B; C544792:dalparvone B