title: Modeling anxiety using adult zebrafish: a conceptual review.
abstract: Zebrafish (Danio rerio) are rapidly emerging as a useful animal model in neurobehavioral research. Mounting evidence shows the suitability of zebrafish to model various aspects of anxiety-related states. Here, we evaluate established and novel approaches to uncover the molecular substrates, genetic pathways and neural circuits of anxiety using adult zebrafish. Experimental approaches to modeling anxiety in zebrafish include novelty-based paradigms, pharmacological and genetic manipulations, as well as innovative video-tracking, 3D-reconstructions, bioinformatics-based searchable databases and omics-based tools. Complementing traditional rodent models of anxiety, we provide a conceptual framework for the wider application of zebrafish and other aquatic models in anxiety research. This article is part of a Special Issue entitled 'Anxiety and Depression'.
authors.affiliation: Department of Pharmacology and Neuroscience Program, Tulane Neurophenotyping Platform, Zebrafish Neuroscience Research Consortium, Tulane University Medical School, 1430 Tulane Ave., New Orleans, LA 70112, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Stewart
authors.forename: Siddharth
authors.initials: S
authors.lastname: Gaikwad
authors.forename: Evan
authors.initials: E
authors.lastname: Kyzar
authors.forename: Jeremy
authors.initials: J
authors.lastname: Green
authors.forename: Andrew
authors.initials: A
authors.lastname: Roth
authors.forename: Allan V
authors.initials: AV
authors.lastname: Kalueff
mesh_terms: D000818:Animals; D001007:Anxiety / Q000473:pathology* / Q000503:physiopathology*; D001362:Avoidance Learning; D003623:Dark Adaptation; D004195:Disease Models, Animal; D005106:Exploratory Behavior; D006801:Humans; D012919:Social Behavior; D015027:Zebrafish