title: Cross-linked, heterogeneous colloidosomes exhibit pH-induced morphogenesis.
abstract: Inspired by morphogenesis in biology, we present a strategy for developing functional 3D materials with the capacity to morph based on environmental cues. We utilized local mechanical stresses to cause global shape changes in colloidosomes. Colloidosomes were assembled from pH-sensitive calcium alginate particles (CAPs) with high and low swelling ratios. Colloidosomes were subsequently cross-linked via diamine compounds with varying carbon chain lengths. New colloidosome isoforms were generated from heterogeneous mixtures of CAPs, which resulted in nonuniform stresses. Our study demonstrated that coordinated networks of heterogeneous subunits may be used to design programmable materials.
authors.affiliation: School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: Jin-Oh
authors.initials: JO
authors.lastname: You
authors.forename: Marjan
authors.initials: M
authors.lastname: Rafat
authors.forename: Debra T
authors.initials: DT
authors.lastname: Auguste
mesh_terms: D000464:Alginates / Q000737:chemistry*; D032701:Biomimetics; D002244:Carbon / Q000737:chemistry; D003102:Colloids; D003959:Diamines / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D013314:Stress, Mechanical
chemical_list: D000464:Alginates; D003102:Colloids; D003959:Diamines; D006603:Hexuronic Acids; D002244:Carbon; D020723:Glucuronic Acid