title: Toward a definition of sarcopenia.
abstract: The definition of sarcopenia has been thoroughly discussed by scientific stakeholders and industry representatives to increase the clinical applicability of the concept. The pooled consensus from 3 of 5 recent and parallel processes, of which 2 are pending, is that sarcopenia is mainly, but not only, an age-related condition defined by the combined presence of reduced muscle mass and muscle function. Contributing factors to sarcopenia are senescence, chronic disease, physical inactivity, and poor food intake. Cachexia may be considered as one etiologic pathway of an accelerated sarcopenia. The adjusted and extended definitions of sarcopenia promote the clinical use of the concept.
authors.affiliation: Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, Dag Hammarskjöldsväg, Sweden. tommy.cederholm@pubcare.uu.se
authors.forename: Tommy E
authors.initials: TE
authors.lastname: Cederholm
authors.forename: Juergen M
authors.initials: JM
authors.lastname: Bauer
authors.forename: Yves
authors.initials: Y
authors.lastname: Boirie
authors.forename: Stephane M
authors.initials: SM
authors.lastname: Schneider
authors.forename: Cornel C
authors.initials: CC
authors.lastname: Sieber
authors.forename: Yves
authors.initials: Y
authors.lastname: Rolland
mesh_terms: D000369:Aged, 80 and over; D000375:Aging; D001823:Body Composition; D016330:Frail Elderly; D006801:Humans; D007391:International Cooperation; D053580:Muscle Strength; D018482:Muscle, Skeletal; D055948:Sarcopenia / Q000209:etiology; D009626:Terminology as Topic