title: Abnormal plasma peptide YY(3-36) levels in patients with liver cirrhosis.
abstract: OBJECTIVE
  Peptide YY(3-36) (PYY(3-36)) is a gut hormone with anorectic action that also affects energy expenditure. Anorexia and malnutrition are often observed in patients with decompensated liver cirrhosis (LC), whereas patients with LC after insertion of transjugular portosystemic stent shunts (TIPS) show normal eating behavior. The underlying mechanism of anorexia in decompensated LC and its resolution in patients with TIPS is still unclear. We thus investigated fasting and postprandial PYY(3-36) serum levels in patients with decompensated LC, patients with compensated LC with in situ TIPS, and healthy controls.
  
  
  METHODS
  We analyzed fasting PYY(3-36) levels in six patients with decompensated LC (four men and two women, 55 ± 11 y of age), nine patients with TIPS (seven men and two women, 48 ± 11 y of age), and 10 controls (eight men and two women, 43 ± 9 y of age) postprandially after a standardized meal of 300 kcal and during 1-h continuous parenteral nutrition. Energy expenditure was determined by indirect calorimetry.
  
  
  RESULTS
  At baseline PYY(3-36) was comparable in controls and patients with TIPS (91 ± 10 and 89 ± 25 ng/L) but was increased in patients with decompensated LC (165 ± 44 ng/L, P < 0.01). Although the cumulative postprandial PYY(3-36) increase was similar in controls (mean 2089 ng/240 min per liter) and patients with decompensated LC (mean 1735 ng/240 min per liter), no postprandial PYY(3-36) increase was observed in patients with TIPS (mean -579 ng/240 min per liter). Parenteral nutrition did not significantly affect PYY(3-36) levels in any group. Fasting PYY(3-36) values were negatively related to resting energy expenditure (r = -0.443, P = 0.030). PYY(3-36) was not associated to liver parameters (e.g., bilirubin, alanine aminotransferase).
  
  
  CONCLUSIONS
  Our results demonstrate an abnormal neuroendocrine regulation of PYY(3-36) in patients with decompensated LC and those with TIPS.
authors.affiliation: Department of Gastroenterology, Hepatology and Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany. luzia.valentini@charite.de
authors.forename: Luzia
authors.initials: L
authors.lastname: Valentini
authors.forename: Tatjana
authors.initials: T
authors.lastname: Schuetz
authors.forename: Ajmal
authors.initials: A
authors.lastname: Omar
authors.forename: Silja
authors.initials: S
authors.lastname: Gläser
authors.forename: Esmatollah
authors.initials: E
authors.lastname: Kasim
authors.forename: Peter
authors.initials: P
authors.lastname: Nowotny
authors.forename: Thomas
authors.initials: T
authors.lastname: Kroencke
authors.forename: Johann
authors.initials: J
authors.lastname: Ockenga
mesh_terms: D000328:Adult; D000368:Aged; D000855:Anorexia / Q000097:blood* / Q000209:etiology; D001481:Basal Metabolism; D016022:Case-Control Studies; D005215:Fasting; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications / Q000601:surgery; D008297:Male; D044342:Malnutrition / Q000209:etiology; D008875:Middle Aged; D010288:Parenteral Nutrition; D019894:Peptide YY / Q000097:blood*; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D019518:Postprandial Period
chemical_list: D019894:Peptide YY