title: An investigation on the fluorescence quenching of 9-aminoacridine by certain pyrimidines.
abstract: The fluorescence quenching of 9-aminoacridine by certain substituted uracils in water was studied using absorption, steady state and time resolved measurements. The bimolecular quenching rate constants (k(q)), binding constant K and number of binding sites (n) were calculated based on the fluorescence quenching data. The free energy change (ΔG(et)) for electron transfer process was calculated by Rehm-Weller equation. From lifetime measurement we observed that the quenching was mainly due to static mechanism involving ground state complex formation.
authors.affiliation: School of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
authors.forename: C
authors.initials: C
authors.lastname: Manivannan
authors.forename: R
authors.initials: R
authors.lastname: Renganathan
mesh_terms: D000585:Aminacrine / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001665:Binding Sites; D004247:DNA / Q000737:chemistry; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D011743:Pyrimidines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013816:Thermodynamics; D014498:Uracil / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D011743:Pyrimidines; D014867:Water; D014498:Uracil; D000585:Aminacrine; D004247:DNA