title: Highly enantioselective cascade synthesis of spiropyrazolones.
abstract: An efficient synthesis of spiropyrazolones based on organocatalysis is described. The reaction between pyrazolones, enolizable aldehydes and enals is catalyzed by secondary amine catalysts and affords the final spiro compounds bearing four contiguous chiral centers in good yields and excellent diastereo- and enantioselectivities.
authors.affiliation: Department de Química Orgànica, Universitat de Barcelona, Martí i Franqués 1-11, 08028, Barcelona, Spain.
authors.forename: Alex
authors.initials: A
authors.lastname: Zea
authors.forename: Andrea-Nekane R
authors.initials: AN
authors.lastname: Alba
authors.forename: Andrea
authors.initials: A
authors.lastname: Mazzanti
authors.forename: Albert
authors.initials: A
authors.lastname: Moyano
authors.forename: Ramon
authors.initials: R
authors.lastname: Rios
mesh_terms: D060326:Chemistry Techniques, Synthetic; D015394:Molecular Structure; D047069:Pyrazolones / Q000138:chemical synthesis* / Q000737:chemistry; D011789:Quantum Theory; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D047069:Pyrazolones; D013141:Spiro Compounds