title: [Therapeutic effects of saponins from Achyranthes bidentata in SHRsp].
abstract: OBJECTIVE
  To study the therapeutic effects of saponins from Achyranthes bidentata (SAB) in stroke-prone sponyaneously hypertension rats (SHRsp).
  
  
  METHODS
  Sixty SHRsp were randomly divided into five groups: SAB 0.10, 0.20, 0.40 g x kg(-1), Huatuo Zaizao pill group (positive control group) 2.5 g x kg(-1) and pathologic group (n=10). SAB and Huatuo Zaizao pill were used through filing stomach everyday for 20 days, pathologic group was given distilled water. The effects of SAB on blood pressure, changes of nerve state, death rate, brain index and the pathologic changes of hippocampal neuron of SHRsp were observed.
  
  
  RESULTS
  SAB could markedly decrease brain index, death rate of SHRsp after stroke. SAB could improve nerve state of SHRsp after stroke. Also SAB could prolong survival time and prevent pathologic change of hippocampal neuron of SHRsp after stroke.
  
  
  CONCLUSIONS
  SAB is advantageous of therapying the stroke in SHRsp.
authors.affiliation: South-Central University for Nationalities, Wuhan 430074, China. sippr1976@163.com
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Maochuan
authors.initials: M
authors.lastname: Liao
mesh_terms: D029044:Achyranthes / Q000737:chemistry*; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D012503:Saponins / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D012503:Saponins