title: MICALs in control of the cytoskeleton, exocytosis, and cell death.
abstract: MICALs form an evolutionary conserved family of multidomain signal transduction proteins characterized by a flavoprotein monooxygenase domain. MICALs are being implicated in the regulation of an increasing number of molecular and cellular processes including cytoskeletal dynamics and intracellular trafficking. Intriguingly, some of these effects are dependent on the MICAL monooxygenase enzyme and redox signaling, while other functions rely on other parts of the MICAL protein. Recent breakthroughs in our understanding of MICAL signaling identify the ability of MICALs to bind and directly modify the actin cytoskeleton, link MICALs to the docking and fusion of exocytotic vesicles, and uncover MICALs as anti-apoptotic proteins. These discoveries could lead to therapeutic advances in neural regeneration, cancer, and other diseases.
authors.affiliation: Department of Neuroscience and Pharmacology, University Medical Center Utrecht, STR 4.229, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
authors.forename: Yeping
authors.initials: Y
authors.lastname: Zhou
authors.forename: Rou-Afza F
authors.initials: RA
authors.lastname: Gunput
authors.forename: Youri
authors.initials: Y
authors.lastname: Adolfs
authors.forename: R Jeroen
authors.initials: RJ
authors.lastname: Pasterkamp
mesh_terms: D020816:Amino Acid Motifs; D017209:Apoptosis; D002135:Calcium-Binding Proteins / Q000737:chemistry; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism*; D005089:Exocytosis; D060588:LIM Domain Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008840:Microfilament Proteins / Q000737:chemistry; D005810:Multigene Family / Q000502:physiology; D011392:Proline / Q000737:chemistry; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D000096985:Calponins
chemical_list: D002135:Calcium-Binding Proteins; D003598:Cytoskeletal Proteins; D060588:LIM Domain Proteins; D008840:Microfilament Proteins; D011392:Proline; D000096985:Calponins