title: Rituximab in steroid refractory autoimmune hemolytic anemia.
abstract: Autoimmune hemolytic anemia is rare in children and infants and steroids are the corner stone of therapy. Management of the patients with steroid refractory/dependent disease is difficult .Rituximab is being used in the treatment of a variety of autoimmune diseases including Autoimmune hemolytic anemia (AIHA),especially in adults but there is scarce data regarding the use of this agent in pediatric AIHA patients.The authors report two cases of steroid refractory AIHA, who responded to rituximab with review the literature of its use in pediatrics.
authors.affiliation: Department of Hematology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
authors.forename: Nitin
authors.initials: N
authors.lastname: Gupta
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Sharma
authors.forename: Tulika
authors.initials: T
authors.lastname: Seth
authors.forename: Pravas
authors.initials: P
authors.lastname: Mishra
authors.forename: Manoranjan
authors.initials: M
authors.lastname: Mahapatra
authors.forename: Suman
authors.initials: S
authors.lastname: Kumar
authors.forename: Rajan
authors.initials: R
authors.lastname: Kapoor
authors.forename: Narendra
authors.initials: N
authors.lastname: Agarwal
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy*; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D002648:Child; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D005938:Glucocorticoids; D007155:Immunologic Factors; D000069283:Rituximab