title: SEOM clinical guidelines for hereditary cancer.
abstract: Research in genetics has facilitated the identification of highly penetrant genes responsible for a large number of diseases. In the oncology field, genetic counselling and gene testing are focused on the two most common syndromes in familial cancer: hereditary breast and ovarian cancer syndrome (HBOC) and hereditary non-polyposis colorectal cancer or Lynch syndrome (LS). The objective of this guideline in hereditary cancer is to summarise the current state of knowledge and make recommendations in the areas of diagnosis, prevention and treatment of hereditary cancer.
authors.affiliation: High Risk and Cancer Prevention Unit, Medical Oncology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. bgrana@vhebron.net
authors.forename: Begoña
authors.initials: B
authors.lastname: Graña
authors.forename: Enrique
authors.initials: E
authors.lastname: Lastra
authors.forename: Gemma
authors.initials: G
authors.lastname: Llort
authors.forename: Joan
authors.initials: J
authors.lastname: Brunet
authors.forename: Dolores
authors.initials: D
authors.lastname: Isla
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D012955:Societies, Medical; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor