title: Regio- and stereoselective synthesis of 2-deoxy-C-aryl glycosides via palladium catalyzed decarboxylative reactions.
abstract: An efficient and versatile approach for the synthesis of 2-deoxy-C-aryl glycosides is reported. This strategy is based on a palladium-catalyzed decarboxylative Heck coupling reaction of benzoic acids and glycals. A wide variety of glycals and benzoic acids have been screened, and all these reactions could afford the desired C-aryl glycoside products in moderate to good yields with exclusive regio- and stereoselectivities.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Xiang
authors.forename: Shuting
authors.initials: S
authors.lastname: Cai
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Liu
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D003653:Decarboxylation; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006027:Glycosides; D009942:Organometallic Compounds; D010165:Palladium