title: Defective neutrophil rolling and transmigration in acute uremia.
abstract: Circulating neutrophils are essential for innate immunity and undergo rapid, stepwise adhesion to and transmigration through the endothelium following tissue injury and microbial invasion. Neutrophil dysfunction may contribute to morbidity and mortality in acute kidney injury but has not frequently been studied at a mechanistic level. Rossaint et al. provide experimental evidence in mice and humans that acute uremia causes discrete intracellular signaling abnormalities that interfere with specific stages of neutrophil trafficking during inflammation.
authors.affiliation: Regenerative Medicine Institute, National Centre for Biomedical Engineering Science and College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Galway, Ireland.
authors.forename: Jana
authors.initials: J
authors.lastname: Pindjakova
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Griffin
mesh_terms: D058186:Acute Kidney Injury / Q000503:physiopathology*; D000818:Animals; D002465:Cell Movement; D036904:Leukocyte Rolling; D015398:Signal Transduction