title: Oral fast-release solid dispersion-paradigm shift to nanoparticles.
abstract: Design of oral fast-release solid dispersion of poorly water-soluble drugs has been a great challenge over past decades on issues of drug recrystallization, drug polymorphism, formulation limited to low drug-to-carrier ratio and drug particle aggregation in matrix. The complexity in solid dispersion design is envisaged to be resolvable by the use of nanoparticulate system as solid dosage form. This manuscript reviews several patented processing approaches of nanoparticulate solid dispersion that have been reported recently. Through drug nanoencapsulation, a higher content of drug may be delivered with less aggregation via placing the same drug mass in a greater number of tinier carriers. Nanoencapsulation, by its own process of formation, brings about submicron particles. Keeping drug in these nanoparticles, a remarkable rise in specific surface area of drug is realized for dissolution. The augmentation of drug dissolution can be sufficiently high to the extent that the influences of polymorphism and crystallization phenomenon on drug dissolution in a solid dispersion may be negligible.
authors.affiliation: Non-Destructive Biomedical and Pharmaceutical Research Centre, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia. wongtinwui@salam.uitm.edu.my
authors.forename: Tin W
authors.initials: TW
authors.lastname: Wong
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000639:trends; D004355:Drug Stability; D004655:Emulsions; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013535:Suspensions; D013678:Technology, Pharmaceutical / Q000639:trends
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D004364:Pharmaceutical Preparations; D013535:Suspensions