title: SiO2@Fe2O3 core-shell nanoparticles for covalent immobilization and release of sparfloxacin drug.
abstract: Silica-coated Fe(2)O(3) nanoparticles were synthesized as carriers for the covalent immobilization and release of antimicrobial drug sparfloxacin (SPFX). SPFX-loaded nanoparticles exhibited time-dependent drug release, with no measurable in vitro cytotoxicity, making the drug@nanoparticle conjugates potentially relevant for nanomedicine applications.
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, 12613 Giza, Egypt. nadinealy@hotmail.com
authors.forename: Nadia E A
authors.initials: NE
authors.lastname: El-Gamel
authors.forename: Laura
authors.initials: L
authors.lastname: Wortmann
authors.forename: Karim
authors.initials: K
authors.lastname: Arroub
authors.forename: Sanjay
authors.initials: S
authors.lastname: Mathur
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000633:toxicity; D002460:Cell Line; D005290:Ferric Compounds / Q000737:chemistry*; D024841:Fluoroquinolones / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D050997:Nanomedicine; D012822:Silicon Dioxide / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000890:Anti-Infective Agents; D005290:Ferric Compounds; D024841:Fluoroquinolones; C000499:ferric oxide; D012822:Silicon Dioxide; C061363:sparfloxacin