title: Novel Taxoid-Based Tumor-Targeting Drug Conjugates.
abstract: A long standing problem of conventional cancer chemotherapy is the lack of tumor specificity. Tumor-targeting drug delivery systems have been explored to overcome this problem. These systems combine a powerful cytotoxic anticancer agent with a tumor-targeting molecule via a suitable linker to form highly efficacious drug-conjugates. These conjugates can deliver potent cytotoxic drugs specifically to tumors and cancer cells with minimal systemic toxicity. This article describes the design, development and application of novel taxoid-based tumor-targeting drug-conjugates, which possess excellent specificity and efficacy in vitro and in vivo.
authors.forename: Manisha
authors.initials: M
authors.lastname: DAS
authors.forename: Edison
authors.initials: E
authors.lastname: Zuniga
authors.forename: Iwao
authors.initials: I
authors.lastname: Ojima