title: Results of liver transplantation with donors older than 70 years: a case-control study.
abstract: Older donors are a growing part of the total pool but no definite consensus exists on the age limit for their acceptance. This retrospective case-control unicenter study compared the outcomes of 72 orthotopic liver transplantations (OLTs) from April 1990 to April 2010 using donors older than 70 years versus 738 chronologically correlated OLTs performed with donors younger than 60 years. The percentage of refusal was greater among older than younger donors (48.2 vs 14.3%; P < .001). No difference was observed in mean cold ischemia times between older (370.5 minutes) versus younger groups (389.2 minutes). or in postoperative complications of rejection or renal insufficiency except for sepsis and mortality. Long-term survival was lower among transplant recipients from donors older than 70 years (P = .001) and these cases showed more blood requirements associated with prolonged cold ischemia (P = .02). Multivariate analysis revealed graft dysfunction, mortality, and reduced survival to be associated with donor weight and recipient MELD (Model for End-stage Liver Disease) (P < .05). Interestingly, the mortality related to hepatitis C virus recurrence was not greater among patients whose donors were older than 70. Septuagenarians' livers can be used safely, but careful donor and recipient evaluation are required to avoid additional risk factors.
authors.affiliation: Liver Transplant Unit, Virgen del Rocío Hospital, Seville, Spain. jmalamom@hotmail.com
authors.forename: J M
authors.initials: JM
authors.lastname: Álamo
authors.forename: L
authors.initials: L
authors.lastname: Barrera
authors.forename: L-M
authors.initials: LM
authors.lastname: Marín
authors.forename: C
authors.initials: C
authors.lastname: Bernal
authors.forename: G
authors.initials: G
authors.lastname: Suárez
authors.forename: J
authors.initials: J
authors.lastname: Serrano
authors.forename: M A
authors.initials: MA
authors.lastname: Gómez
authors.forename: F J
authors.initials: FJ
authors.lastname: Padillo
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D046148:Donor Selection; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects / Q000276:immunology / Q000401:mortality; D008875:Middle Aged; D055031:Primary Graft Dysfunction / Q000209:etiology; D051437:Renal Insufficiency / Q000209:etiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013030:Spain; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D016896:Treatment Outcome