title: Synthesis, computational studies and preliminary pharmacological evaluation of 2-[4-(aryl substituted) piperazin-1-yl] N, N-diphenylacetamides as potential antipsychotics.
abstract: A series of 2-[4-(aryl substituted) piperazin-1-yl] N, N-diphenylacetamides have been synthesized and the target compounds (3a-j) were evaluated for atypical antipsychotic activity in apomorphine induced climbing, 5-HTP induced head twitches behavior and catalepsy studies in mice. The physicochemical similarity of the target compounds with respect to standard drugs clozapine, ketanserin and risperidone was calculated by using software programs. Among them, compound 3e showed maximum atypical antipsychotic like profile.
authors.affiliation: Drug Design & Medicinal Chemistry Research Laboratory, College of Pharmacy, IFTM, Moradabad 244001, UP, India. sushilmpharm@rediffmail.com
authors.forename: Sushil
authors.initials: S
authors.lastname: Kumar
authors.forename: A K
authors.initials: AK
authors.lastname: Wahi
authors.forename: Ranjit
authors.initials: R
authors.lastname: Singh
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000081:Acetamides; D014150:Antipsychotic Agents; D010879:Piperazines