title: The relationship between adiponectin, an adiponectin gene polymorphism, and high-density lipoprotein particle size: from the Mima study.
abstract: This study examined the association among serum adiponectin levels, a single nucleotide polymorphism (SNP) of the adiponectin gene, and the size of serum high-density lipoprotein (HDL) particles in a general population. A total of 275 subjects were examined as part of the community-based Mima study. Serum adiponectin levels were measured with an enzyme-linked immunosorbent assay. Serum small-sized HDL was measured with the electrophoretic separation of lipoproteins using the Lipoprint system. Single nucleotide polymorphism G276T (rs1501299, SNP276) of the adiponectin gene was determined with a fluorescent allele-specific DNA primer assay system. Age- and sex-adjusted correlation test revealed a significant inverse relationship between small-sized HDL and adiponectin levels (r = -0.236, P < .001). More percentages of small-sized HDL were observed in the subjects with the SNP276 G/G and G/T genotypes than in those with the T/T genotype (5.5% ± 5.0% vs 3.0% ± 2.9%, P = .016). In a multiple regression analysis, small-sized HDL was significantly and independently correlated with triglycerides levels (β = 0.133, P = .030), adiponectin levels (β = -0.242, P < .001), and the SNP276 G allele (β = -0.142, P = .014). Our findings indicated that adiponectin and SNP276 of the adiponectin gene may modify the size of HDL particles.
authors.affiliation: Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors.forename: Kokoro
authors.initials: K
authors.lastname: Tsuzaki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Sano
authors.forename: Shinji
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Irene F
authors.initials: IF
authors.lastname: Gazi
authors.forename: Moses
authors.initials: M
authors.lastname: Elisaf
authors.forename: Naoki
authors.initials: N
authors.lastname: Sakane
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000235:genetics*; D000368:Aged; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000737:chemistry; D008297:Male; D010316:Particle Size; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D008075:Lipoproteins, HDL; D014280:Triglycerides