title: Adjuvant temozolomide chemotherapy for treatment of papillary tumor of the pineal region.
abstract: BACKGROUND
  We present a personal case of papillary pineocytoma in a 42-year-old woman.
  
  
  METHODS
  The lesion was first treated surgically both for diagnostic aims and for resolution of the mass effect causing hydrocephalus and correlated neurological disturbances. Because the tumor recurred after surgery and radiotherapy, we decided to further treat the patient with chemotherapy, in particular with temozolomide.
  
  
  RESULTS
  Currently, almost 9 years after the first treatment, the patient is symptom-free and follow-up magnetic resonance imaging shows no tumor recurrence.
  
  
  CONCLUSIONS
  Although surgery should be considered the first-choice therapy, we think that temozolomide can be a valid option in case of recurrence of these rare tumors.
authors.affiliation: Neurosurgery, Department of Neurological Sciences, Ospedale Maggiore, Mangiagalli e Regina Elena, Fondazione Policlinico, Istituto di Ricovero e Cura a Carattere Scientifico, and Department of Medicine, Surgery, and Dentistry, University of Milan, Milan, Italy. marwinx@gmail.com
authors.forename: Martin
authors.initials: M
authors.lastname: Lorenzetti
authors.forename: Federica
authors.initials: F
authors.lastname: Motta
authors.forename: Rolando
authors.initials: R
authors.lastname: Campanella
authors.forename: Dario
authors.initials: D
authors.lastname: Bauer
authors.forename: Agnese
authors.initials: A
authors.lastname: Assi
authors.forename: Cesare
authors.initials: C
authors.lastname: Arienta
authors.forename: Sergio Maria
authors.initials: SM
authors.lastname: Gaini
authors.forename: Manuela
authors.initials: M
authors.lastname: Caroli
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D002291:Carcinoma, Papillary / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D020233:Gait Disorders, Neurologic / Q000209:etiology; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures; D009886:Ophthalmoplegia / Q000209:etiology; D010871:Pinealoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D000077204:Temozolomide; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000209:etiology
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide