title: A cool channel in cold transduction.
abstract: Transient receptor potential melastatin 8 (TRPM8), a calcium-permeable cation channel activated by cold, cooling compounds and voltage, is the main molecular entity responsible for detection of cold temperatures in the somatosensory system. Here, we review the biophysical properties, physiological role, and near-membrane trafficking of this exciting polymodal ion channel.
authors.affiliation: Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.
authors.forename: Ramón
authors.initials: R
authors.lastname: Latorre
authors.forename: Sebastián
authors.initials: S
authors.lastname: Brauchi
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Madrid
authors.forename: Patricio
authors.initials: P
authors.lastname: Orio
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D003080:Cold Temperature; D006801:Humans; D015398:Signal Transduction; D050053:TRPM Cation Channels / Q000502:physiology*; D013697:Thermosensing / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D050053:TRPM Cation Channels