title: Overcoming antiangiogenic resistance.
abstract: The success of drugs targeting angiogenesis is tempered by the transient duration of disease control and modest survival improvement. The very hypoxic stress produced by successful therapy may lead to upregulation of multiple pathways that promote angiogenesis and invasive behavior. Overcoming this evasive resistance may further improve outcome.
authors.affiliation: Department of Gastrointestinal Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, USA. jyao@mdanderson.org
authors.forename: James C
authors.initials: JC
authors.lastname: Yao
authors.forename: Alexandria
authors.initials: A
authors.lastname: Phan
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D006801:Humans; D018358:Neuroendocrine Tumors / Q000188:drug therapy*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D014227:Triazines / Q000494:pharmacology*
chemical_list: D014227:Triazines; C509922:brivanib; D000409:Alanine