title: Acute West Nile virus neuroinvasive infections: cross-reactivity with dengue virus and tick-borne encephalitis virus.
abstract: Cross-reactions in serology are common among flaviviruses. During the outbreak of West Nile virus (WNV) infections in Greece in 2010, WNV IgM-positive serum and cerebrospinal fluid samples were tested for the presence of IgM and IgG antibodies against Dengue virus (DENV) and tick-borne encephalitis virus. Higher cross-reactivity was observed in IgM antibodies between WNV and DENV; however, the index of the WNV antibodies was in all cases higher than that of the DENV antibodies. There is a need for caution when evaluating serologic results of flaviviral infections, while efforts have to be focused on the development of diagnostic assays with increased specificity.
authors.affiliation: Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. annap@med.auth.gr
authors.forename: Anna
authors.initials: A
authors.lastname: Papa
authors.forename: Dimitra
authors.initials: D
authors.lastname: Karabaxoglou
authors.forename: Athina
authors.initials: A
authors.lastname: Kansouzidou
mesh_terms: D000914:Antibodies, Viral / Q000097:blood* / Q000134:cerebrospinal fluid*; D003429:Cross Reactions; D003716:Dengue Virus / Q000276:immunology*; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006115:Greece; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000097:blood / Q000134:cerebrospinal fluid; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D014901:West Nile Fever / Q000175:diagnosis / Q000276:immunology*; D014902:West Nile virus / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic