title: Alpha-Fetoprotein-Producing Extrahepatic Tumor: Clinical and Histopathological Significance of a Case.
abstract: BACKGROUND
  The serum rise of alpha-fetoprotein (AFP) has been relationed to hepatic tumors. Other than these, such as gastric adenocarcinoma, can present with high levels of this glycoprotein. One rare kind of gastric adenocarcinoma, called hepatoid subtype, has two essential features: hepatoid differentiation in histology and high levels of AFP in serum.
  
  
  CONCLUSIONS
  We report a Spanish female who consulted because of fatigue, anorexia, and weight loss. In laboratory data, she presented anemia and markedly elevation of AFP. On CT scan, a gastric mass resulted without hepatic dissemination, and subsequently, gastroduodenoscopy was performed for histological diagnosis. Then, an ulcerated mass was detected and sample was taken, resulting in poorly-differentiated adenocarcinoma of stomach with hepatoid tissue foci, with intense positivity for AFP-immunohistochemical staining. This rare cancer has poor prognosis even with early gastrectomy and chemotherapy.
authors.affiliation: Emergency Department, Rapid diagnosis Unit, Madrid, Spain. jose_nuevo@hotmail.com.|Emergency department, Hospital Gregorio Marañón, C/Doctor Esquerdo, 46, 28007, Madrid, Spain. jose_nuevo@hotmail.com.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Nuevo-Gonzalez
authors.affiliation: Emergency Department, Rapid diagnosis Unit, Madrid, Spain.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Cano-Ballesteros
authors.affiliation: Department of Pathology, Hospital Gregorio Marañón, Madrid, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Lopez
authors.affiliation: Emergency Department, Rapid diagnosis Unit, Madrid, Spain.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Andueza-Lillo
authors.affiliation: Department of Internal Medicine, Hospital Gregorio Marañón, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Audibert
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D003131:Combined Modality Therapy; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins