title: Protein solubility and protein homeostasis: a generic view of protein misfolding disorders.
abstract: According to the "generic view" of protein aggregation, the ability to self-assemble into stable and highly organized structures such as amyloid fibrils is not an unusual feature exhibited by a small group of peptides and proteins with special sequence or structural properties, but rather a property shared by most proteins. At the same time, through a wide variety of techniques, many of which were originally devised for applications in other disciplines, it has also been established that the maintenance of proteins in a soluble state is a fundamental aspect of protein homeostasis. Taken together, these advances offer a unified framework for understanding the molecular basis of protein aggregation and for the rational development of therapeutic strategies based on the biological and chemical regulation of protein solubility.
authors.affiliation: Department of Chemistry, University of Cambridge, United Kingdom.
authors.forename: Michele
authors.initials: M
authors.lastname: Vendruscolo
authors.forename: Tuomas P J
authors.initials: TP
authors.lastname: Knowles
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Dobson
mesh_terms: D006706:Homeostasis; D006801:Humans; D007700:Kinetics; D017510:Protein Folding; D057165:Proteostasis Deficiencies / Q000378:metabolism*; D012995:Solubility; D013816:Thermodynamics