title: Combinatorial patterns of histone modifications in Saccharomyces cerevisiae.
abstract: Histone modification is an important subject of epigenetics that plays an intrinsic role in transcriptional regulation. It has been suggested that multiple histone modifications act in a combinatorial fashion to form a 'histone code'. In this study, the combinatorial patterns of histone modifications were studied by using a Bayesian network at the level of individual nucleosomes in S. cerevisiae. Our results indicated that there were 23 combinatorial patterns for 12 histone modifications investigated when a general Bayesian network was constructed. Meanwhile, different networks were also constructed for the genes with high transcript levels (H-network) and low transcript levels (L-network), respectively. Comparison among the general network, H-network and L-network illustrated four conserved combinations: H2BK16Ac → H3K4me3; H3K14Ac → H3K4me3; H2AK7Ac → H3K14Ac; and H4K12Ac → H3K18Ac. The detailed analysis for some combinations demonstrated that the combinations were ascribed to some histone-modifying enzymes.
authors.affiliation: School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Xiang-Jun
authors.initials: XJ
authors.lastname: Cui
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Liu
mesh_terms: D044127:Epigenesis, Genetic; D015966:Gene Expression Regulation, Fungal; D042421:Histone Code; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D006657:Histones; D029701:Saccharomyces cerevisiae Proteins