title: Hemocompatibility investigation of the NiTi alloy implanted with tantalum.
abstract: A composite TiO(2)/Ta(2)O(5) nano-film has been formed on the NiTi shape memory alloy by Ta implantation. The wettability, protein adsorption, platelets adhesion and hemolysis tests are conducted to evaluate the hemocompatibility. The contact angle measurements showed that the surface of the NiTi alloy kept hydrophilic before and after Ta implantation, although the water contact angle increased with the increasing of implantation current. Both of the surface energy and the interfacial tension decreased after Ta implantation. The protein adsorption behavior was investigated by (125)I isotope labeling. The fibrinogen adsorption was enhanced by a high surface roughness or a large interfacial tension, while the albumin adsorption was insensitive to the surface modification. Platelet adhesion and activation were weakened and the hemolysis rate was reduced at least 46% after Ta implantation due to the decreased surface energy and improved corrosion resistance ability, respectively.
authors.affiliation: School of Materials Science and Engineering, Beihang University, #37, Xueyuan Road, Beijing, 100191, People's Republic of China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Yuzhi
authors.initials: Y
authors.lastname: Gao
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000009:adverse effects; D001769:Blood / Q000187:drug effects*; D001792:Blood Platelets / Q000166:cytology / Q000502:physiology; D002448:Cell Adhesion; D006461:Hemolysis; D006801:Humans; D008855:Microscopy, Electron, Scanning; D009532:Nickel / Q000009:adverse effects* / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D013314:Stress, Mechanical; D013635:Tantalum / Q000009:adverse effects* / Q000737:chemistry*; D014025:Titanium / Q000009:adverse effects* / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D011506:Proteins; C040654:titanium nickelide; D013635:Tantalum; D009532:Nickel; D014025:Titanium