title: [Study on optimization of formulation of Danggui Liuhuang effervescent granules].
abstract: OBJECTIVE
  To optimize the formulation of Danggui Liuhuang effervescent granules.
  
  
  METHODS
  By means of quadratic regression rotation-orthogonal combination design, the effect of the proper proportion between citric acid and sodium bicarbonate, as well as the proper quantity of polyethylene glycol 6000 and sodium cyclamate on the dissolubility and pH of effervescent granules was studied.
  
  
  RESULTS
  The best formulation was as follows: citric acid: sodium bicarbonate = 0.75: 1, the percentage of polyethylene glycol 6000 and cyclamate was 3.25% and 0.89%, respectively.
  
  
  CONCLUSIONS
  The dissolubility and pH of the effervescent granules are better and the taste is satisfactory.
authors.affiliation: Tianjin Key Laboratory of Food Biotechnology/College of Biotechonlogy & Food Science, Tianjin University of Commerce, Tianjin 300134, China. zhping@tjcu.edu.cn
authors.forename: Ping
authors.initials: P
authors.lastname: Zheng
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Meng
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Sun
authors.forename: Wen-Zhong
authors.initials: WZ
authors.lastname: Wang
mesh_terms: D000704:Analysis of Variance; D002626:Chemistry, Pharmaceutical; D019343:Citric Acid / Q000008:administration & dosage* / Q000737:chemistry; D003494:Cyclamates / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011786:Quality Control; D017693:Sodium Bicarbonate / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical
chemical_list: D003494:Cyclamates; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005079:Excipients; D019343:Citric Acid; D011092:Polyethylene Glycols; D017693:Sodium Bicarbonate