title: [Heterogeneity of bone metastases in a patient with breast cancer: case report illustrating the potential of combining various imaging techniques].
abstract: Morphological appearance of bone metastases in breast cancer can be classified into three groups: osteolytic, sclerotic and mixed types. 18F-NaF PET/CT is considered to be superior to bone scintigraphy (BS) for the detection of bone metastases. 18F-NaF PET shows a higher uptake in both lytic and sclerotic bone metastases with a higher contrast and spatial resolution than BS. 18F-FDG PET is generally considered to be superior to BS for detection of lytic bone metastases. However, BS and 18F-NaF PET/CT are more sensitive for sclerotic lesions, as a decreased 18F-FDG uptake in this subtype of lesion has been reported. In conclusion, as various types of bone metastases may coexist in a single patient, the combination of both 18F-FDG and 18F-fluoride PET/CT studies is likely to provide the most comprehensive assessment of metastatic spread to the skeleton.
authors.affiliation: Service de Médecine nucléaire, CHU de Liège, Belgique.
authors.forename: N
authors.initials: N
authors.lastname: Withofs
authors.forename: J
authors.initials: J
authors.lastname: Collignon
authors.forename: A
authors.initials: A
authors.lastname: Rorive
authors.forename: G
authors.initials: G
authors.lastname: Jerusalem
authors.forename: R
authors.initials: R
authors.lastname: Hustinx
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18