title: Application of time-varying analysis to diagnostic needle electromyography.
abstract: Quantification in clinical, diagnostic electromyography (EMG) currently includes motor unit action potential (MUAP) analysis and interference pattern analysis. Early efforts to examine the frequency/power spectra of the interference pattern showed modest value but the technique was not developed further. This paper re-examines spectral analysis, extending it into the time-varying domain, which has never been studied in diagnostic needle EMG. Time-frequency and time-scale analysis employing wavelet and non-wavelet techniques were applied to short trains of MUAPs. The results show that time-varying analysis produces clear visual representations of the energy content of individual MUAPs within an interference pattern. The time frequency representations allow easy, qualitative distinction between normal and neurogenic MUAPs. Furthermore, the quantified MUAP energy correlates well with the current morphological standard and the quantification process is substantially faster. Time-varying analysis links classical power spectral analysis in the realm of interference patterns with quantitative MUAP analysis. In addition to morphological classification, MUAPs might also be classified by energy content, which more closely reflects the physical and physiological consequences of neuromuscular pathology on the motor unit.
authors.affiliation: University of California, San Diego, Neuromuscular Division, 402 Dickinson Street, Suite 190, San Diego, CA 92103-8465, USA. gsheean@ucsd.edu
authors.forename: Geoffrey L
authors.initials: GL
authors.lastname: Sheean
mesh_terms: D000200:Action Potentials; D002138:Calibration; D004576:Electromyography / Q000295:instrumentation* / Q000592:standards; D009046:Motor Neurons / Q000166:cytology; D009339:Needles; D012015:Reference Standards; D013997:Time Factors