title: Long-term treatment of refractory invasive fungal infection with posaconazole: additive value of therapeutic drug monitoring.
abstract: Posaconazole is a recently developed broad-spectrum triazole antifungal with potential for long-term prophylaxis or therapy of invasive fungal infections. This case illustrates the additive value for therapeutic drug monitoring to guide clinical decision-making in high risk patients.
authors.affiliation: Afdeling Algemene Inwendige Geneeskunde, Leuven, Belgie. liesbet.henckaerts@uza.be
authors.forename: L
authors.initials: L
authors.lastname: Henckaerts
authors.forename: I
authors.initials: I
authors.lastname: Spriet
authors.forename: W
authors.initials: W
authors.lastname: Meersseman
authors.forename: W E
authors.initials: WE
authors.lastname: Peetermans
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D001232:Aspergillus fumigatus; D002851:Chromatography, High Pressure Liquid; D016903:Drug Monitoring; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000382:microbiology; D006801:Humans; D008297:Male; D055732:Pulmonary Aspergillosis / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence; D014230:Triazoles / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole