title: The Ripoptosome: death decision in the cytosol.
abstract: In this issue of Molecular Cell, Tenev et al. and Feoktistova et al. describe the Ripoptosome, a cytosolic death-inducing RIP1-, FADD-, and caspase-8-containing complex that spontaneously assembles upon cIAP depletion, challenging the view that such complexes exclusively originate from receptor activation.
authors.affiliation: Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium. mathieu.bertrand@dmbr.vib-ugent.be
authors.forename: Mathieu J M
authors.initials: MJ
authors.lastname: Bertrand
authors.forename: Peter
authors.initials: P
authors.lastname: Vandenabeele