title: tRNA structural and functional changes induced by oxidative stress.
abstract: Oxidatively damaged biomolecules impair cellular functions and contribute to the pathology of a variety of diseases. RNA is also attacked by reactive oxygen species, and oxidized RNA is increasingly recognized as an important contributor to neurodegenerative complications in humans. Recently, evidence has accumulated supporting the notion that tRNA is involved in cellular responses to various stress conditions. This review focuses on the intriguing consequences of oxidative modification of tRNA at the structural and functional level.
authors.affiliation: Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112, Sienkiewicza Street, 90-363 Lodz, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Nawrot
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Sochacka
authors.forename: Markus
authors.initials: M
authors.lastname: Düchler
mesh_terms: D004734:Energy Metabolism; D008957:Models, Genetic; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012343:RNA, Transfer / Q000737:chemistry* / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013455:Sulfur / Q000737:chemistry
chemical_list: D017382:Reactive Oxygen Species; D013455:Sulfur; D012343:RNA, Transfer