title: N-heterocyclic carbene-catalyzed aza-Michael addition.
abstract: Aza-Michael addition of amines, including aromatic and aliphatic amines, with α, β-unsaturated ketones was realized employing N-Heterocyclic Carbene (NHC) as organocatalyst, yielding β-amino ketones with up to 98% yield.
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Kang
authors.forename: Yugen
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000588:Amines; D006571:Heterocyclic Compounds; D007659:Ketones; C030011:carbene; D008697:Methane