title: [Sterile non-traumatic corneal perforation treated with Tachosil®].
abstract: METHODS
  An 83 year-old male reported to the emergency room with red eye and ocular pain. The slit-lamp examination showed a central corneal perforation of 1mm in diameter, with no associated infection or inflammatory process. The patient had no history of trauma. It was decided to apply a patch of Tachosil(®) at the site of corneal perforation. After 36 hours of occlusion, a layer of fibrin covered the perforation, closing the defect. Successful healing of the corneal perforation was observed in the follow-up, with no recurrences of the process.
  
  
  CONCLUSIONS
  Tachosil(®) is collagen sponge with human fibrin and human thrombin used in cardiological and neurosurgical surgery for haemostasis and the occlusion of vessels and meninges. We present the first indication in ophthalmology of Tachosil(®) as an effective alternative in the treatment of sterile non-traumatic corneal perforations less than 1.5 mm in size.
authors.affiliation: Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España. rafael.canones@gmail.com
authors.forename: R
authors.initials: R
authors.lastname: Cañones-Zafra
authors.forename: J
authors.initials: J
authors.lastname: Benítez-Herreros
authors.forename: K
authors.initials: K
authors.lastname: Kubiak
authors.forename: M A
authors.initials: MA
authors.lastname: Montes-Mollón
authors.forename: R
authors.initials: R
authors.lastname: Jiménez-Parras
mesh_terms: D020341:Absorbable Implants; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications; D019072:Antibiotic Prophylaxis; D003261:Contact Lenses; D057112:Corneal Perforation / Q000209:etiology / Q000628:therapy*; D003320:Corneal Ulcer / Q000150:complications; D004338:Drug Combinations; D005340:Fibrinogen / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008525:Medroxyprogesterone / Q000627:therapeutic use; D009184:Mydriatics / Q000627:therapeutic use; D015503:Surgical Sponges; D013917:Thrombin / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D009184:Mydriatics; C518955:TachoSil; D005340:Fibrinogen; D013917:Thrombin; D008525:Medroxyprogesterone