title: Comparison of drug resistance scores for tipranavir in protease inhibitor-naive patients infected with HIV-1 B and non-B subtypes.
abstract: Genotypes of samples from protease inhibitor-naïve patients in Frankfurt's HIV Cohort were analyzed with five tipranavir resistance prediction algorithms. Mean scores were higher in non-B than in B subtypes. The proportion of non-B subtypes increased with increasing scores, except in weighted algorithms. Virtual and in vitro phenotype analyses of samples with increased scores showed no reduced tipranavir susceptibility. Current algorithms appear suboptimal for interpretation of resistance to tipranavir in non-B subtypes; increased scores might reflect algorithm bias rather than "natural resistance."
authors.affiliation: Johann Wolfgang Goethe-University Hospital, Institute for Medical Virology, Frankfurt, Germany. M.Stuermer@em.uni-frankfurt.de
authors.forename: Martin
authors.initials: M
authors.lastname: Stürmer
authors.forename: Christoph
authors.initials: C
authors.lastname: Stephan
authors.forename: Peter
authors.initials: P
authors.lastname: Gute
authors.forename: Gaby
authors.initials: G
authors.lastname: Knecht
authors.forename: Markus
authors.initials: M
authors.lastname: Bickel
authors.forename: Hans-Reinhard
authors.initials: HR
authors.lastname: Brodt
authors.forename: Hans W
authors.initials: HW
authors.lastname: Doerr
authors.forename: Lutz
authors.initials: L
authors.lastname: Gürtler
authors.forename: Pierre
authors.initials: P
authors.lastname: Lecocq
authors.forename: Margriet
authors.initials: M
authors.lastname: van Houtte
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D009154:Mutation; D011725:Pyridines / Q000627:therapeutic use*; D011753:Pyrones / Q000627:therapeutic use*; D013449:Sulfonamides
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D011725:Pyridines; D011753:Pyrones; D013449:Sulfonamides; C107201:tipranavir