title: Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia.
abstract: The interplay of amyloid and mitochondrial function is considered crucial in the pathophysiology of Alzheimer's disease (AD). We tested the association of the putative marker of mitochondrial function N-acetylaspartate (NAA) as measured by proton magnetic resonance spectroscopy within the medial temporal lobe and cerebrospinal fluid amyoid-β42 (Aβ42), total Tau and pTau181. 109 patients were recruited in a multicenter study (40 mild AD patients, 14 non-AD dementia patients, 29 mild cognitive impairment (MCI) AD-type patients, 26 MCI of non-AD type patients). NAA correlated with Aβ42 within the AD group. Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and Aβ42 may reflect the interaction between disrupted mitochondrial pathways and amyloid production.
authors.affiliation: Department of Psychiatry, University of Bonn, Bonn, Germany. Frank.Jessen@ukb.uni-bonn.de
authors.forename: Frank
authors.initials: F
authors.lastname: Jessen
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewczuk
authors.forename: Okan
authors.initials: O
authors.lastname: Gür
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Block
authors.forename: Gabriele
authors.initials: G
authors.lastname: Ende
authors.forename: Lutz
authors.initials: L
authors.lastname: Frölich
authors.forename: Thilo
authors.initials: T
authors.lastname: Hammen
authors.forename: Sönke
authors.initials: S
authors.lastname: Arlt
authors.forename: Johannes
authors.initials: J
authors.lastname: Kornhuber
authors.forename: Thomas
authors.initials: T
authors.lastname: Kucinski
authors.forename: Julius
authors.initials: J
authors.lastname: Popp
authors.forename: Oliver
authors.initials: O
authors.lastname: Peters
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Frank
authors.initials: F
authors.lastname: Träber
authors.forename: Jens
authors.initials: J
authors.lastname: Wiltfang
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D015415:Biomarkers / Q000134:cerebrospinal fluid / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000378:metabolism; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D001224:Aspartic Acid; C000179:N-acetylaspartate