title: Two new casbane diterpenoids from the roots of Euphorbia pekinensis.
abstract: From the roots of Euphorbia pekinensis, two new casbane diterpenoids, named pekinenins A (1) and B (2), were isolated. Their structures were elucidated as 18-hydroxy-1βH,2αH-casba-3E,7E,11E-trien-5-one (1), 5α-methoxy-1βH,2αH-casba-3Z,7E,11E-trien-18-oic acid (2) by a combination of 1D and 2D NMR spectroscopy and mass spectrometry. In the cytotoxicity assay of the two new compounds against Hela, MCF-7, and C6 human cancer cell lines, compound 1 showed moderate cytotoxic activity against two human cancer cell lines, Hela and C6, with IC(50) values of 42.97 and 50.00 μM, respectively.
authors.affiliation: School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Feng-Guang
authors.initials: FG
authors.lastname: Shao
authors.forename: Ren
authors.initials: R
authors.lastname: Bu
authors.forename: Cui
authors.initials: C
authors.lastname: Zhang
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C561953:pekinenin A; C561952:pekinenin B