title: Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case-control study.
abstract: BACKGROUND
  Insulin-like growth factor-I (IGF-I) and C-reactive protein (CRP) may be positively associated with the risk of epithelial ovarian cancer (EOC) but no previous studies have investigated their associations with non-epithelial ovarian cancers (NEOC).
  
  
  METHODS
  A case-control study was nested within the Finnish Maternity Cohort. Case subjects were 58 women diagnosed with sex cord-stromal tumors (SCST) and 30 with germ cell tumors (GCT) after recruitment. Control subjects (144 for SCST and 74 for GCT) were matched for age, parity, and date of blood donation of the index case.
  
  
  RESULTS
  Doubling of IGF-I concentration was not related to maternal risk of either SCST (OR 0.97, 95% CI 0.58-1.62) or GCT (OR 1.13, 95% CI 0.51-2.51). Similarly, doubling of CRP concentrations was not related to maternal risk of either SCST (OR 1.10, 95% CI 0.85-1.43) or GCT (OR 0.93, 95% CI 0.68-1.28).
  
  
  CONCLUSIONS
  Pre-diagnostic IGF-I and CRP concentrations during the first trimester of pregnancy were not associated with increased risk of NEOC in the mother. Risk factors for NEOC may differ from those of EOC.
authors.affiliation: National Institute for Health and Welfare, Finland. Adetunji.toriola@nct-heidelberg.de
authors.forename: Adetunji T
authors.initials: AT
authors.lastname: Toriola
authors.forename: Helja-Marja
authors.initials: HM
authors.lastname: Surcel
authors.forename: Eva
authors.initials: E
authors.lastname: Lundin
authors.forename: Helena
authors.initials: H
authors.lastname: Schock
authors.forename: Kjell
authors.initials: K
authors.lastname: Grankvist
authors.forename: Eero
authors.initials: E
authors.lastname: Pukkala
authors.forename: Tianhui
authors.initials: T
authors.lastname: Chen
authors.forename: Paolo
authors.initials: P
authors.lastname: Toniolo
authors.forename: Matti
authors.initials: M
authors.lastname: Lehtinen
authors.forename: Anne
authors.initials: A
authors.lastname: Zeleniuch-Jacquotte
authors.forename: Annekatrin
authors.initials: A
authors.lastname: Lukanova
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein