title: In vivo biocompatibility of three potential intraperitoneal implants.
abstract: The intraperitoneal biocompatibility of PDMS, polyHEMA and pEVA was investigated in rats, rabbits and rhesus monkeys. No inflammation was evidenced by hematological analyses and measurement of inflammatory markers throughout the experiment and by post-mortem examination of the pelvic cavity. After 3 or 6 months, histological analysis revealed fibrous tissue encapsulating PDMS and PEVA implants in all species and polyHEMA implants in rabbits and monkeys. Calcium deposits were observed inside polyHEMA implants. The intraperitoneal biocompatibility of all 3 polymers makes them suitable for the design of drug delivery systems, which may be of great interest for pathologies confined to the pelvic cavity.
authors.affiliation: Université Catholique de Louvain, Institut de Recherche Clinique et Expérimentale, Department of Gynecology, Avenue Hippocrate 10, 1200 Brussels, Belgium.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Defrère
authors.forename: Mélanie
authors.initials: M
authors.lastname: Mestagdt
authors.forename: Raphaël
authors.initials: R
authors.lastname: Riva
authors.forename: Fabrice
authors.initials: F
authors.lastname: Krier
authors.forename: Anne
authors.initials: A
authors.lastname: Van Langendonckt
authors.forename: Pierre
authors.initials: P
authors.lastname: Drion
authors.forename: Christine
authors.initials: C
authors.lastname: Jérôme
authors.forename: Brigitte
authors.initials: B
authors.lastname: Evrard
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Dehoux
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Foidart
authors.forename: Jacques
authors.initials: J
authors.lastname: Donnez
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002097:C-Reactive Protein / Q000378:metabolism; D004129:Dimethylpolysiloxanes / Q000494:pharmacology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D007249:Inflammation / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism; D008253:Macaca mulatta; D008422:Materials Testing / Q000379:methods*; D010529:Peritoneal Cavity / Q000473:pathology*; D011102:Polyhydroxyethyl Methacrylate / Q000494:pharmacology; D011145:Polyvinyls / Q000494:pharmacology; D019736:Prostheses and Implants; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D018836:Inflammation Mediators; D011145:Polyvinyls; C016438:ethylenevinylacetate copolymer; D011102:Polyhydroxyethyl Methacrylate; D005340:Fibrinogen; D002097:C-Reactive Protein