title: [Preliminary clinical study on the treatment of severe infantile hemangioma with high-dose propranolol in China].
abstract: OBJECTIVE
  To investigate the clinical results of the treatment of severe infantile hemangioma with high-dose propranolol in Chinese.
  
  
  METHODS
  56 cases with severe infantile hemangioma were treated with propranolol. Clinical evaluation, electrocardiography, and experimental examination of liver function and heart function were performed before treatment. The daily dose of propranolol was increased from 1 mg/kg at the first day to 1.5 mg/kg at the second day, and to 2 mg/kg at the third day. The propranolol was given twice a day. The treatment was lasted for six months. The patients were visited every month.
  
  
  RESULTS
  The lesion color was changed after 2-4 days of treatment in all the cases. All the lesions were dramatically improved after one month of treatment. The ulceration were healed, except one case. Until now, complete regression was achieved in 10 cases and marked improvement in 46 cases. Side effects were happened in 3 cases, including one case of abnormal liver function, one case of CK-MB increase and one case of continuous increase of CK-MB, LDH, ALT, GGT.
  
  
  CONCLUSIONS
  High-dose Propranolol is very effective in the treatment of infantile hemangioma with minor side effects and short disease period. It might he used as the first-line treatment for infantile hemangioma.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Fujian Medical University Affiliated Union Hospital, Fuzhou 350001, China.
authors.forename: Ming-kun
authors.initials: MK
authors.lastname: Zhan
authors.forename: Yi-de
authors.initials: YD
authors.lastname: Xie
authors.forename: Zhi-hui
authors.initials: ZH
authors.lastname: Guo
authors.forename: Ba-rui
authors.initials: BR
authors.lastname: Huang
authors.forename: Ya-kuan
authors.initials: YK
authors.lastname: Zhou
authors.forename: Xiao-song
authors.initials: XS
authors.lastname: Chen
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Yu-cheng
authors.initials: YC
authors.lastname: Yang
mesh_terms: D002681:China; D005260:Female; D006391:Hemangioma / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D011433:Propranolol / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D011433:Propranolol