title: The catalytic asymmetric 1,3-dipolar cycloaddition of ynones with azomethine ylides.
abstract: The first catalytic asymmetric 1,3-dipolar cycloaddition of electron-deficient carbon-carbon triple bonds with azomethine ylides has been established. This reaction provides an unprecedented approach to access novel 2,5-dihydropyrrole derivatives with potential bioactivities in perfect enantioselectivities of up to >99% ee.
authors.affiliation: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, 221116, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Shi-Wei
authors.initials: SW
authors.lastname: Luo
authors.forename: Zhong-Lin
authors.initials: ZL
authors.lastname: Tao
authors.forename: Long
authors.initials: L
authors.lastname: He
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011789:Quantum Theory; D013237:Stereoisomerism; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D001391:Azo Compounds; D007659:Ketones; D013882:Thiosemicarbazones; C512188:azomethine