title: A coincidence of addiction to "Kratom" and severe primary hypothyroidism.
abstract: Here we present a case of a coincidence of addiction to "Kratom" (botanically known as Mitragyna speciosa Korth) and developed severe primary hypothyroidism. We are discussing a possibility that high dose of indole alkaloid mitragynine (the major alkaloid identified from "Kratom") might reduce the normal response of the thyroid gland to thyroid-stimulating hormone resulting in primary hypothyroidism. Further experimental investigations of mitragynine as a possible suppressor of thyroid gland function would be a matter of interest.
authors.affiliation: Cleveland Clinic Alcohol and Drug Recovery Center, Cleveland, OH, USA. ssheleg@yahoo.com
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Sheleg
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Collins
mesh_terms: D000328:Adult; D002047:Buprenorphine / Q000627:therapeutic use; D015897:Comorbidity; D004359:Drug Therapy, Combination; D006801:Humans; D007011:Hypoparathyroidism / Q000453:epidemiology* / Q000534:rehabilitation; D008297:Male; D032065:Mitragyna / Q000009:adverse effects*; D058850:Opiate Substitution Treatment; D010936:Plant Extracts / Q000009:adverse effects*; D046948:Secologanin Tryptamine Alkaloids / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000534:rehabilitation; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D010936:Plant Extracts; D046948:Secologanin Tryptamine Alkaloids; D002047:Buprenorphine; C001801:mitragynine; D013974:Thyroxine