title: Relation of left ventricular mass to QTc in normotensive severely obese patients.
abstract: Prolongation of the corrected QT interval (QTc) has been described in obese subjects. This study assesses the relation of left ventricular (LV) mass to QTc in normotensive severely obese subjects. Fifty normotensive patients whose BMI was ≥40 kg/m(2) (mean age: 38 ± 7 years) were studied. QTc was derived using Bazett's formula. LV mass was calculated using the formula of Devereux et al. and was indexed to height(2.7). Mean QTc was 428.8 ± 19.0 ms and was significantly longer in those with than in those without LV hypertrophy (P < 0.01) QTc correlated positively and significantly with BMI (r = 0.392, P < 0.025), LV mass/height(2.7) (r = 0.793, P < 0.0005), systolic blood pressure (r = 0.742, P < 0.001), LV end - systolic wall stress (r = 0.746, P < 0.001) and LV internal dimension in diastole (r = 0.788, P < 0.0005). Among five variables tested, LV mass/height(2.7) was identified as the sole predictor of QTc by multivariate analysis. In conclusion, LV mass and loading conditions that may affect LV mass are important determinants of QTc in normotensive severely obese subjects.
authors.affiliation: Division of Cardiovascular Medicine and Department of Surgery, University of Missouri School of Medicine, Columbia, Missouri, USA.
authors.forename: Rita
authors.initials: R
authors.lastname: Mukerji
authors.forename: Boyd E
authors.initials: BE
authors.lastname: Terry
authors.forename: John L
authors.initials: JL
authors.lastname: Fresen
authors.forename: Marius
authors.initials: M
authors.lastname: Petruc
authors.forename: Gurushankar
authors.initials: G
authors.lastname: Govindarajan
authors.forename: Martin A
authors.initials: MA
authors.lastname: Alpert
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D001794:Blood Pressure; D015331:Cohort Studies; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D008297:Male; D009767:Obesity, Morbid / Q000503:physiopathology* / Q000601:surgery; D011446:Prospective Studies; D020257:Ventricular Remodeling; D015431:Weight Loss