title: Role of metalloproteinases in rotator cuff tear.
abstract: The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPS) in the pathophysiology of rotator cuff tears has not been established yet. Recent advances empathize about the role of MMPs and TIMPS in extracellular matrix (ECM) remodeling and degradation in rotator cuff tears pathogenesis and healing after surgical repair. An increase in MMPs synthesis and the resulting MMPs mediated alterations in the ECM of tendons have been implicated in the etiopathogenesis of tendinopathy, and there is an increase in the expression of MMPs and a decrease in TIMP messenger ribonucleic acid expression in tenocytes from degenerative or ruptured tendons. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and bisphosphonates. A better understanding of relationship and activity of these molecules could provide better strategies to optimize outcomes of rotator cuff therapy.
authors.affiliation: Department of Orthopedic and Traumatology, F Miulli Hospital, Acquaviva delle fonti, Bari, Italy. raffaelegarofalo@gmail.com
authors.forename: Raffaele
authors.initials: R
authors.lastname: Garofalo
authors.forename: Eugenio
authors.initials: E
authors.lastname: Cesari
authors.forename: Enzo
authors.initials: E
authors.lastname: Vinci
authors.forename: Alessandro
authors.initials: A
authors.lastname: Castagna
mesh_terms: D006801:Humans; D045726:Metalloproteases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D017006:Rotator Cuff / Q000201:enzymology* / Q000503:physiopathology; D000070636:Rotator Cuff Injuries; D013708:Tendon Injuries / Q000188:drug therapy / Q000201:enzymology; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism*
chemical_list: D019714:Tissue Inhibitor of Metalloproteinases; D045726:Metalloproteases