title: The role of Ki-67 in predicting biological behavior of goblet cell carcinoid tumor in appendix.
abstract: BACKGROUND
  The aim of this study was to examine the role of Ki-67, a cellular proliferation marker, in the prognosis of goblet cell appendiceal carcinoid tumor.
  
  
  METHODS
  Twelve goblet cell appendiceal carcinoid tumors were stained with MIB-1, a monoclonal antibody of Ki-67, to assess their cell proliferation and correlations with clinical and histologic parameters.
  
  
  RESULTS
  Among 12 patients studied, the mean MIB-1 index was 24%, with tumors ranging from .5 to 5.0 cm in size. No correlation was observed between tumor size and MIB-1 index. Two patients had metastatic disease on presentation (MIB-1 index 10% and 60%). All patients received surgical intervention according to extent of tumor invasion regardless of their MIB-1 index values. Median follow-up was 54 months, with a 75% follow-up rate and 1 death from metastasis. The overall survival rate was 76%, with a disease-specific survival rate of 87%.
  
  
  CONCLUSIONS
  Ki-67 had no prognostic significance for goblet cell carcinoid tumors and should not be used solely to determine treatment and surgical approach.
authors.affiliation: Division of General Surgery, Department of Surgery, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Liu
authors.forename: Dana A
authors.initials: DA
authors.lastname: Telem
authors.forename: Richard R P
authors.initials: RR
authors.lastname: Warner
authors.forename: Andrew
authors.initials: A
authors.lastname: Dikman
authors.forename: Celia M
authors.initials: CM
authors.lastname: Divino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001063:Appendiceal Neoplasms / Q000473:pathology* / Q000601:surgery; D001065:Appendix / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000502:physiology*; D002276:Carcinoid Tumor / Q000473:pathology* / Q000601:surgery; D049109:Cell Proliferation; D005260:Female; D020397:Goblet Cells / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen