title: Role of growth factors in rotator cuff healing.
abstract: The histologic lesion underlying overuse rotator cuff tendinopathy is a failed healing response, with haphazard proliferation of tenocytes, disruption of tendon cells and collagen fibers, and increased noncollagenous extracellular matrix. Recent attention has focused on the biological pathways by which tendons heal, leading to the identification of several growth factors (GFs) involved in this process. No studies have been published on the time course of the various GFs during rotator cuff healing process in vivo, in humans. We review what is known about these GFs and their role in rotator cuff healing.
authors.affiliation: Department of Orthopaedics and Traumatology, University of Rome Tor Vergata School of Medicine, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Oliva
authors.forename: Alessio Giai
authors.initials: AG
authors.lastname: Via
authors.forename: Nicola
authors.initials: N
authors.lastname: Maffulli
mesh_terms: D012090:Cumulative Trauma Disorders / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology* / Q000627:therapeutic use; D017006:Rotator Cuff / Q000378:metabolism; D000070636:Rotator Cuff Injuries; D013708:Tendon Injuries / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D036341:Intercellular Signaling Peptides and Proteins