title: [Study on intra-gastric floating beads of naringenin].
abstract: OBJECTIVE
  To prepare calcium alginate-chitosan intra-gastric floating beads of naringenin combining with the solid dispersion method and investigate the in vitro floating characteristics, entrapment efficiency and drug release property of the beads.
  
  
  METHODS
  The solid dispersion of naringenin was prepared by the Eudragit RLPO. Sodium alginate solution mixed with the powder of the solid dispersion of naringenin and frother was slowly dripped into chitosan-calcium chloride solution added with acetic acid. Calcium alginatechitosan intra-gastric floating beads of naringenin were obtained after drying. The effects of solid dispersion on in vitro release of naringenin were investigated.
  
  
  RESULTS
  Intra-gastric floating beads of naringenin were acquired successfully. More than 70% of the beads kept floating in artificial gastric juice in 9 h, the release ratio of naringenin during 9 h was 65%-70% and the entrapment efficiency was about 70%-80%.
  
  
  CONCLUSIONS
  The sustained release of naringenin in the calcium alginate-chitosan intra-gastric floating beads could be achieved by using the solid dispersion method and it provides some ideas of intra-gastric floating preparations.
authors.affiliation: School of Pharmacy, Chongqing 400016, China. j_h_m_t_h@yahoo.com.cn
authors.forename: Hui-ming
authors.initials: HM
authors.lastname: Jiang
authors.forename: Liang-ke
authors.initials: LK
authors.lastname: Zhang
authors.forename: Pei
authors.initials: P
authors.lastname: Yuan
authors.forename: Cheng-yuan
authors.initials: CY
authors.lastname: Wang
authors.forename: You-qi
authors.initials: YQ
authors.lastname: Long
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002122:Calcium Chloride / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D044950:Flavanones / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D005750:Gastric Juice; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D010316:Particle Size; D011126:Polypropylenes / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D044950:Flavanones; D006603:Hexuronic Acids; D011126:Polypropylenes; D020723:Glucuronic Acid; D048271:Chitosan; C005273:naringenin; D002122:Calcium Chloride