title: Long-term effects of a community-based lifestyle intervention to prevent type 2 diabetes: the DEPLOY extension pilot study.
abstract: OBJECTIVE
  The US Diabetes Prevention Program (DPP) and other large trials internationally have shown that an intensive lifestyle intervention can reduce the development of type 2 diabetes. We evaluated long-term effects of a lower cost, group-based adaption of the DPP lifestyle intervention offered by the YMCA.
  
  
  METHODS
  Participants were adults with BMI ≥24 kg/m(2) and random capillary blood glucose 6.1-11.1 mmol/L who had been previously enrolled in a cluster-randomized trial comparing a group-based DPP lifestyle intervention versus brief advice alone. Four to 12 months after completion of the initial trial, 72% of 92 participants enrolled in an extension study, and all were offered a group lifestyle maintenance program at the YMCA. Paired t-tests were used to assess within-group changes; ANCOVA with adjustment was used for between-group comparisons.
  
  
  RESULTS
  At 28 months, after both arms were offered the same 8-month lifestyle maintenance intervention, both arms had statistically significant weight losses compared to baseline (brief advice controls: -3.6%; 95% CI: -5.8 to -1.4; intensive lifestyle: -6.0%; 95% CI: -8.8 to -3.2). Participants initially assigned to the DPP also experienced significant improvements in blood pressure and total cholesterol.
  
  
  CONCLUSIONS
  The YMCA is a promising channel for dissemination of a low-cost model for lifestyle diabetes prevention. Future studies are needed to verify these findings.
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. rtackerm@iupui.edu
authors.forename: Ronald T
authors.initials: RT
authors.lastname: Ackermann
authors.forename: Emily A
authors.initials: EA
authors.lastname: Finch
authors.forename: Helena M
authors.initials: HM
authors.lastname: Caffrey
authors.forename: Elaine R
authors.initials: ER
authors.lastname: Lipscomb
authors.forename: Laura M
authors.initials: LM
authors.lastname: Hays
authors.forename: Chandan
authors.initials: C
authors.lastname: Saha
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D019058:Community Networks; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007196:Indiana; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011615:Psychotherapy, Group; D040242:Risk Reduction Behavior; D015431:Weight Loss
chemical_list: D002784:Cholesterol