title: Differentiating Parkinson's disease from multiple system atrophy by [123I] meta-iodobenzylguanidine myocardial scintigraphy and olfactory test.
abstract: We aimed to study whether either [(123)l] myocardial meta-iodobenzylguanidine (MIBG) myocardial scintigraphy or the odor stick identification test for Japanese (OSIT-J) is effective in differentiating Parkinson's disease (PD) from multiple system atrophy (MSA). We compared the MIBG accumulation and olfactory score between 42 PD and 42 MSA (19 MSA-P and 23 MSA-C) patients in the early stages. [(123)l] MIBG myocardial scintigraphy showed higher sensitivity and the olfactory test higher specificity in differentiating PD from MSA. There were significant differences between PD and MSA-C (p = 0.0019) instead of MSA-P (p > 0.05) in the MIBG accumulation, while there were significant differences between PD and MSA-P (p = 0.0003) or MSA-C (p = 0.0003) in the OSIT-J score. Our data suggest that the olfactory test can be useful as a clinical tool with its higher specificity in differentiating PD from MSA in the early stages and, moreover, support the discrimination of PD from MSA-P.
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. akikuchi@med.tohoku.ac.jp
authors.forename: Akio
authors.initials: A
authors.lastname: Kikuchi
authors.forename: Toru
authors.initials: T
authors.lastname: Baba
authors.forename: Takafumi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Naoto
authors.initials: N
authors.lastname: Sugeno
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Konno
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeda
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications / Q000175:diagnosis*; D055414:Myocardial Perfusion Imaging; D000857:Olfaction Disorders / Q000175:diagnosis / Q000209:etiology; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis*; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine