title: Effectiveness of intraperitoneal hyperthermo-chemotherapy for malignant peritoneal mesothelioma and estimation of its effect by repeated FDG-PET: a case report.
abstract: Malignant peritoneal mesothelioma is a rare neoplasm derived from the peritoneum of the abdominal cavity. Here, we report on a case of malignant peritoneal mesothelioma that expanded aggressively after initial surgery, followed by successful treatment with cytoreductive surgery, intra-abdominal hyperthermo-chemotherapy, to allow the patient to perform daily activities with reduced symptoms. The therapeutic effects were monitored by FDG-PET/CT. The patient, a 55-year-old female, was referred to our hospital with a diagnosis of pelvic tumor. Laparotomy and cytoreductive surgery revealed the diagnosis of malignant mesothelioma. The tumor progressed rapidly in the abdominal cavity, so cytoreduction and intra-abdominal hyperthermo-chemotherapy were performed as strong local therapies. In addition, monthly hyperthermo-chemotherapy was performed. The patient lived for 21 months after the first surgery. Severe bowel obstruction and malignant ascites did not appear. Cancerous pain was controllable throughout this portion of her life. In conclusion, we experienced a case of malignant peritoneal mesothelioma and treated it with hyperthermo-chemotherapy. This treatment helped the patient to maintain daily activities throughout the remainder of her life. Thus, hyperthermo-chemotherapy can be considered an option in the treatment of malignant peritoneal mesothelioma.
authors.affiliation: Department of General Surgical Science, Gunma University Graduate School, Graduate School of Medicine, Gunma, Japan. syamaguc@med.gunma-u.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Asao
authors.forename: Soichi
authors.initials: S
authors.lastname: Tsutsumi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Fujii
authors.forename: Hayato
authors.initials: H
authors.lastname: Yamauchi
authors.forename: Wakako
authors.initials: W
authors.lastname: Kigure
authors.forename: Hiroki
authors.initials: H
authors.lastname: Morita
authors.forename: Reina
authors.initials: R
authors.lastname: Yajima
authors.forename: Toshinaga
authors.initials: T
authors.lastname: Suto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D003131:Combined Modality Therapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D006979:Hyperthermia, Induced; D008654:Mesothelioma / Q000000981:diagnostic imaging / Q000628:therapy*; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18