title: Microsatellite instability analysis in uterine cavity washings as a screening tool for endometrial cancer in Lynch syndrome.
abstract: Although patients with Lynch syndrome (LS) are at high risk of endometrial cancer, gynecologic screening has been poorly investigated and diagnostic value of current screening tests remains unclear. Microsatellite instability (MSI) phenotype is found in more than 90% of endometrial cancers developed in LS patients. Here we report the first two cases of unstable endometrial tumors with detection of MSI in uterine cavity washings cells. This new technique may be a promising screening tool in LS.
authors.affiliation: Université Paris Descartes, Paris, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Bouquier
authors.forename: Hélène
authors.initials: H
authors.lastname: Blons
authors.forename: Céline
authors.initials: C
authors.lastname: Narjoz
authors.forename: Fabrice
authors.initials: F
authors.lastname: Lécuru
authors.forename: Pierre
authors.initials: P
authors.lastname: Laurent-Puig
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Bats
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000231:Adenocarcinoma, Papillary / Q000175:diagnosis* / Q000235:genetics; D018269:Carcinoma, Endometrioid / Q000175:diagnosis* / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000235:genetics; D053843:DNA Mismatch Repair; D004252:DNA Mutational Analysis; D004268:DNA-Binding Proteins / Q000235:genetics; D055088:Early Detection of Cancer / Q000379:methods; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D006801:Humans; D053842:Microsatellite Instability; D008875:Middle Aged; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D007507:Therapeutic Irrigation; D014599:Uterus / Q000166:cytology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; C501486:MLH1 protein, human; D009687:Nuclear Proteins; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein