title: [Determination of cinnamic acid and glycyrrhizic acid in rat serum and its pharmacokinetics after oral administration of Dangguisini decoction].
abstract: OBJECTIVE
  To mensurate concentrations and pharmacokinetics of cinnamic acid and glycyrrhizic acid in rats after oral adiministration Dangguisini decoction.
  
  
  METHODS
  To Determine serum concentration of cinnamic acid and glycyrrhizic acid by High-Performance Liquid Chromatography and calculate its parameter of pharmacokinetics in rats after oral administration of Dangguisini decoction via 3P97 software.
  
  
  RESULTS
  Parameters of Pharmacokinetics of cinnamic acid and glycyrrhizic acid were Cmax 9.2008 (mg/L), AUC 304.0734 (mg/L) x min and Cmax 51.1330(mg/L), AUC 21476.9688 (mg/L) x min respectively in rats after oral administration of Dangguisini decoction.
  
  
  CONCLUSIONS
  Absorption of cinnamic acid is quick and its metabolize is quick too, but metabolism of glycyrrhizic acid is oppositely slow in rats after oral administration of Dangguisini decoction.
authors.affiliation: Medical college,Jinan university, Guangzhou 510632 China. gaoyuqin1234567@yahoo.com.cn
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Gao
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Ren-Wang
authors.initials: RW
authors.lastname: Jiang
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Zhao
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002934:Cinnamates / Q000097:blood / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D019695:Glycyrrhizic Acid / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D002934:Cinnamates; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C029010:cinnamic acid; D019695:Glycyrrhizic Acid