title: Sartoryglabrins, analogs of ardeemins, from Neosartorya glabra.
abstract: Chemical investigation of a collection of the fungus Neosartorya glabra from Thailand furnished sartoryglabins A-C (1a, 1b and 2) which are analogs of the reverse prenylated indole alkaloids known as (-) ardeemins. Structures of these compounds were established by NMR spectrometry and an X-ray analysis. Sartoryglabins A-C were evaluated for their in vitro growth inhibitory activity on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma). All the compounds exhibited strong to moderate activity against the MCF-7 cell line but weak or no activity against the NCI-H460 and A375-C5 cell lines. Sartoryglabin B was found to exhibit selectivity towards the MCF-7 cell line.
authors.affiliation: ICBAS- Instituto de Ciêncas Biomédicas de Abel Salazar and CIIMAR, Universidade do Porto, 4099-003 Porto, Portugal. ankijjoa@icbas.up.pt
authors.forename: Anake
authors.initials: A
authors.lastname: Kijjoa
authors.forename: Sonia
authors.initials: S
authors.lastname: Santos
authors.forename: Tida
authors.initials: T
authors.lastname: Dethoup
authors.forename: Leka
authors.initials: L
authors.lastname: Manoch
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Almeida
authors.forename: Maria Helena
authors.initials: MH
authors.lastname: Vasconcelos
authors.forename: Artur
authors.initials: A
authors.lastname: Silva
authors.forename: Luís
authors.initials: L
authors.lastname: Gales
authors.forename: Werner
authors.initials: W
authors.lastname: Herz
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D055326:Neosartorya / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; C560650:sartoryglabrin A; C560651:sartoryglabrin B; C560652:sartoryglabrin C