title: Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia.
abstract: Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.
authors.affiliation: Psychology Department, University of Otago, P.O. Box 56, Dunedin, New Zealand.
authors.forename: Amy R
authors.initials: AR
authors.lastname: Wolff
authors.forename: Kirsten R
authors.initials: KR
authors.lastname: Cheyne
authors.forename: David K
authors.initials: DK
authors.lastname: Bilkey
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001526:Behavioral Symptoms / Q000209:etiology* / Q000473:pathology; D004192:Discrimination, Psychological; D004195:Disease Models, Animal; D005260:Female; D006624:Hippocampus / Q000473:pathology; D011070:Poly I-C / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D021641:Recognition, Psychology / Q000502:physiology; D012193:Reversal Learning; D012559:Schizophrenia / Q000150:complications* / Q000276:immunology
chemical_list: D011070:Poly I-C