title: A replication study of the IRS1, CAPN10, TCF7L2, and PPARG gene polymorphisms associated with type 2 diabetes in two different populations of Mexico.
abstract: Type 2 diabetes (T2D) is a chronic degenerative disease that involves the participation of several genetic and environmental factors. The objective of the study was to determine the association of the IRS1 (rs1801278), CAPN10 (rs3792267), TCF7L2 (rs7903146 and rs12255372), and PPARG (rs1801282) gene polymorphisms with T2D, in two different Mexican populations. We conducted a case-control replication study in the state of Guerrero and in Mexico City, with 400 subjects from Guerrero and 1065 from Mexico City. Data were analyzed by logistic regression, adjusting by ancestry, age, gender, and BMI, to determine the association with T2D. Heterozygosity for the Gly972Arg variant of the IRS1 gene showed the strongest association for T2D in both analyzed samples (OR = 2.43, 95% CI 1.12-5.26 and 2.64, 95% CI 1.37-5.10, respectively). In addition, an association of two SNPs of the TCF7L2 gene with T2D was observed in both cities: rs7903146, (for Guerrero OR = 1.98 CI95% 1.02-3.89 and for Mexico OR = 1.94 CI95% 1.31-2.88) and rs12255372 (OR = 1.79 CI95% 1.08-2.97, OR = 1.78 CI95% 1.17-2.71 respectively). We suggest that our results provide strong evidence that variation in the IRS1 and TCF7L2 genes confers susceptibility to T2D in our studied populations.
authors.affiliation: Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, México.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Martínez-Gómez
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
authors.forename: Gabriela A
authors.initials: GA
authors.lastname: Martínez-Nava
authors.forename: Vicente
authors.initials: V
authors.lastname: Madrid-Marina
authors.forename: Esteban
authors.initials: E
authors.lastname: Parra
authors.forename: Jaime
authors.initials: J
authors.lastname: García-Mena
authors.forename: Mónica
authors.initials: M
authors.lastname: Espinoza-Rojo
authors.forename: Barbara I
authors.initials: BI
authors.lastname: Estrada-Velasco
authors.forename: Luis F
authors.initials: LF
authors.lastname: Piza-Roman
authors.forename: Penelope
authors.initials: P
authors.lastname: Aguilera
authors.forename: Ana I
authors.initials: AI
authors.lastname: Burguete-García
mesh_terms: D000328:Adult; D000368:Aged; D002154:Calpain / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
chemical_list: C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; D047495:PPAR gamma; D058118:Transcription Factor 7-Like 2 Protein; D002154:Calpain; C415197:calpain 10