title: Multicentric Castleman's disease as a cause for unclear febrile episodes in a 55-year-old HIV-infected man.
abstract: Our case illustrates the difficulties involved in diagnosing multicentric Castleman's disease (MCD) in a human immunodeficiency virus-infected man with febrile episodes and malaise. In the absence of well-established treatment protocols, we have chosen a new treatment algorithm with rituximab, etoposide, and valganciclovir, which led to the remission of clinical symptoms. Yet, we advocate focused exploration for MCD in immunosuppressed patients with unclear febrile episodes, as recent advances in treatment are promising.
authors.affiliation: Department of Internal Medicine, University of Zurich, Zurich, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Lederer
authors.forename: Y
authors.initials: Y
authors.lastname: Achermann
authors.forename: M
authors.initials: M
authors.lastname: Tinguely
authors.forename: F
authors.initials: F
authors.lastname: Stenner
authors.forename: J
authors.initials: J
authors.lastname: Fehr
mesh_terms: D000465:Algorithms; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D005871:Castleman Disease / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D004359:Drug Therapy, Combination; D005047:Etoposide / Q000627:therapeutic use; D015774:Ganciclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D000069283:Rituximab; D003294:Seizures, Febrile / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D016896:Treatment Outcome; D000077562:Valganciclovir
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D007155:Immunologic Factors; D000069283:Rituximab; D005047:Etoposide; D000077562:Valganciclovir; D015774:Ganciclovir