title: Time-course of changes in inflammatory response after whole-body cryotherapy multi exposures following severe exercise.
abstract: The objectives of the present investigation was to analyze the effect of two different recovery modalities on classical markers of exercise-induced muscle damage (EIMD) and inflammation obtained after a simulated trail running race. Endurance trained males (n = 11) completed two experimental trials separated by 1 month in a randomized crossover design; one trial involved passive recovery (PAS), the other a specific whole body cryotherapy (WBC) for 96 h post-exercise (repeated each day). For each trial, subjects performed a 48 min running treadmill exercise followed by PAS or WBC. The Interleukin (IL) -1 (IL-1), IL-6, IL-10, tumor necrosis factor alpha (TNF-α), protein C-reactive (CRP) and white blood cells count were measured at rest, immediately post-exercise, and at 24, 48, 72, 96 h in post-exercise recovery. A significant time effect was observed to characterize an inflammatory state (Pre vs. Post) following the exercise bout in all conditions (p<0.05). Indeed, IL-1β (Post 1 h) and CRP (Post 24 h) levels decreased and IL-1ra (Post 1 h) increased following WBC when compared to PAS. In WBC condition (p<0.05), TNF-α, IL-10 and IL-6 remain unchanged compared to PAS condition. Overall, the results indicated that the WBC was effective in reducing the inflammatory process. These results may be explained by vasoconstriction at muscular level, and both the decrease in cytokines activity pro-inflammatory, and increase in cytokines anti-inflammatory.
authors.affiliation: Research Department, National Institute of Sport, Expertise and Performance (INSEP), Paris, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Pournot
authors.forename: François
authors.initials: F
authors.lastname: Bieuzen
authors.forename: Julien
authors.initials: J
authors.lastname: Louis
authors.forename: Rémi
authors.initials: R
authors.lastname: Mounier
authors.forename: Jean-Robert
authors.initials: JR
authors.lastname: Fillard
authors.forename: Etienne
authors.initials: E
authors.lastname: Barbiche
authors.forename: Christophe
authors.initials: C
authors.lastname: Hausswirth
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000097:blood; D003198:Computer Simulation; D018592:Cross-Over Studies; D017679:Cryotherapy; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology* / Q000628:therapy; D018836:Inflammation Mediators / Q000097:blood*; D007375:Interleukin-1 / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007962:Leukocytes; D008297:Male; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10