title: p53 codon 72 polymorphism and coronary artery disease: evidence of association with left ventricular ejection fraction.
abstract: BACKGROUND
  Recently, there has been a surge of interest on the possible relationship between p53 polymorphism and coronary atherosclerosis. The authors have investigated the possible association of p53 codon 72 polymorphism with left ventricular ejection fraction (LVEF) in subjects with and without coronary artery disease (CAD).
  
  
  METHODS
  The authors have studied 198 subjects admitted consecutively to Valmontone Hospital for CAD and 129 subjects admitted for cardiovascular diseases without CAD. Fifty-nine subjects admitted for CAD to Division of Cardiac Surgery of Tor Vergata University were also studied. All subjects were from the white population. The p53 polymorphism was evaluated using the restriction fragment length polymorphism polymerase chain reaction.
  
  
  RESULTS
  p53 codon 72 polymorphism is a significant independent predictor of LVEF in subjects with CAD but not in subjects with cardiovascular disease without CAD. In subjects with CAD, LVEF is significantly lower in subjects carrying the *Pro variant than in *Arg/*Arg subjects. This effect is more evident in subjects with a positive history of infarction.
  
  
  CONCLUSIONS
  Our study points to a significant relationship of p53 codon 72 polymorphism with cardiac function in subjects with CAD.
authors.affiliation: Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy. Electronic address: gloria@med.uniroma2.it.
authors.forename: Fulvia
authors.initials: F
authors.lastname: Gloria-Bottini
authors.affiliation: Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Saccucci
authors.affiliation: Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Magrini
authors.affiliation: Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Egidio
authors.initials: E
authors.lastname: Bottini
authors.affiliation: Department of Cardiology, Valmontone Hospital, Rome, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Banci
authors.affiliation: Department of Cardiology, Valmontone Hospital, Rome, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Papetti
authors.affiliation: Department of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Nardi
authors.affiliation: Department of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Scognamiglio
authors.affiliation: Department of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellegrino
authors.affiliation: Department of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Chiariello
mesh_terms: D000328:Adult; D000368:Aged; D003062:Codon / Q000235:genetics*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D004452:Echocardiography; D005260:Female; D016158:Genes, p53; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012384:Rome / Q000453:epidemiology; D013318:Stroke Volume
chemical_list: D003062:Codon