title: Investigation of the binding of roxatidine acetate hydrochloride with cyclomaltoheptaose (β-cyclodextrin) using IR and NMR spectroscopy.
abstract: NMR chemical shift changes of the cyclomaltoheptaose (β-cyclodextrin, β-CD) cavity protons as well as roxatidine acetate hydrochloride aromatic ring protons revealed the formation of a RAH-β-CD inclusion complex. Detailed FTIR and NMR spectroscopic ((1)H NMR, COSY, NOESY, ROESY) studies have been done. The stoichiometry of the complex was determined to be 1:1, and the overall binding constant was also determined by Scott's method. The NOESY spectrum confirmed the selective penetration of the aromatic ring of RAH into the β-CD cavity in comparison to that of the piperidine ring. The mode of penetration of the guest into the CD cavity and structure of the complex has been established.
authors.affiliation: Department of Chemistry, Mangalayatan University, Beswan, Aligarh, India. arti_maheshwari2002@yahoomail.com
authors.forename: Arti
authors.initials: A
authors.lastname: Maheshwari
authors.forename: Manisha
authors.initials: M
authors.lastname: Sharma
authors.forename: Deepak
authors.initials: D
authors.lastname: Sharma
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D010880:Piperidines; D047392:beta-Cyclodextrins; C053742:roxatidine acetate