title: Association of variations in TPH1 and HTR2B with gestational weight gain and measures of obesity.
abstract: Serotonin is involved in appetite regulation and energy homeostasis. Recently, it has been reported that 5-hydroxytryptamine receptor 2B (Htr2b) and tryptophan hydroxylase 1 (Tph1) play major role in β-cell proliferation in mouse during pregnancy. We investigated the genetic association of HTR2B and TPH1 with risk of gestational diabetes mellitus (GDM) and measures of obesity, in 869 Korean GDM women and carefully selected 632 nondiabetic control subjects. Six single-nucleotide polymorphisms (SNPs) in HTR2B and ten SNPs in TPH1 were selected for genotyping according to their tagging status. Genetic variants in HTR2B and TPH1 were not associated with the risk of GDM. In GDM women, SNPs of TPH1 were significantly associated with weight gain during pregnancy. In nondiabetic controls, SNPs of TPH1 were associated with waist circumference and BMI. We also found that a variant of TPH1 (rs623580) was associated with BMI in a genome-wide association study comprised of 8,842 subjects. Although genetic variants in HTR2B and TPH1 were not associated with risk of GDM, we found significant association of these variants with measures of obesity. However, further replication studies in a different population are required to confirm our findings.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Soo Heon
authors.initials: SH
authors.lastname: Kwak
authors.forename: Byoung Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Hail
authors.initials: H
authors.lastname: Kim
authors.forename: Michael S
authors.initials: MS
authors.lastname: German
authors.forename: Min Jin
authors.initials: MJ
authors.lastname: Go
authors.forename: Hye Seung
authors.initials: HS
authors.lastname: Jung
authors.forename: Bo Kyong
authors.initials: BK
authors.lastname: Koo
authors.forename: Young Min
authors.initials: YM
authors.lastname: Cho
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Choi
authors.forename: Yoon Shin
authors.initials: YS
authors.lastname: Cho
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Hak C
authors.initials: HC
authors.lastname: Jang
authors.forename: Kyong Soo
authors.initials: KS
authors.lastname: Park
mesh_terms: D000328:Adult; D000818:Animals; D044466:Asian People / Q000235:genetics*; D005260:Female; D006801:Humans; D051379:Mice; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*; D044403:Receptor, Serotonin, 5-HT2B / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology; D012701:Serotonin / Q000235:genetics; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D015430:Weight Gain / Q000235:genetics*
chemical_list: D044403:Receptor, Serotonin, 5-HT2B; D012701:Serotonin; C497467:TPH1 protein, human; D014365:Tryptophan Hydroxylase