title: From Pauling's abzyme concept to the new era of hydrolytic anti-DNA autoantibodies: a link to rational vaccine design? - A review.
abstract: Specific entities of naturally-occurring DNA hydrolytic/cytotoxic antibodies (abzymes) are linked to autoimmune and lymphoproliferative disorders. Suggested sequence of underlying activities conform to such entities penetrating the living cells, trans-locating to nucleus and recognising specific binding sites within single- or double-stranded DNA. Their origin is unknown since corresponding immunogens are unidentified. These anti-DNA antibodies could be the organism's immune response to microbial attack. Their structure, function and pathogenicity were investigated in wet-lab and via bioinformatics in context of Rational Vaccine Designs. This paper offers a comprehensive critical review on the subject in the light of known and newly proposed concepts.
authors.affiliation: Department of Computer and Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, Florida 33431, USA. mpavlovi@fau.edu
authors.forename: Mirjana
authors.initials: M
authors.lastname: Pavlovic
authors.forename: Michelle
authors.initials: M
authors.lastname: Cavallo
authors.forename: Anna
authors.initials: A
authors.lastname: Kats
authors.forename: Alex
authors.initials: A
authors.lastname: Kotlarchyk
authors.forename: Hanqi
authors.initials: H
authors.lastname: Zhuang
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000974:Antibodies, Antinuclear; D017151:Antibodies, Catalytic; D001323:Autoantibodies; D001483:Base Sequence; D004247:DNA; D014612:Vaccines
chemical_list: D000974:Antibodies, Antinuclear; D017151:Antibodies, Catalytic; D001323:Autoantibodies; D014612:Vaccines; D004247:DNA