title: Synthesis of cyclopentenols and cyclopentenones via nickel-catalyzed reductive cycloaddition.
abstract: Strategies for the reductive cycloaddition of enals or enoates with alkynes have been developed. The enal-alkyne cycloaddition directly affords cyclopentenols, whereas the enoate-alkyne cycloaddition affords the analogous cyclopentenones. The mechanism of these processes likely involves formation and protonation of a metallacyclic intermediate. The general strategy provides a straightforward entry to five-membered ring products from simple, stable π-systems.
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
authors.forename: Aireal D
authors.initials: AD
authors.lastname: Jenkins
authors.forename: Ananda
authors.initials: A
authors.lastname: Herath
authors.forename: Minsoo
authors.initials: M
authors.lastname: Song
authors.forename: John
authors.initials: J
authors.lastname: Montgomery