title: Localized fluid collection after carrier-bound fibrin sealant application on liver: complication or proof of efficacy? A long-term clinical observational study.
abstract: OBJECTIVE
  This study was intended to evaluate the incidence and the long-term outcome of fluid collecting between the hepatic resection surface and a collagen patch. To our knowledge, this is the first study to analyze these aspects.
  
  
  METHODS
  All patients undergoing hepatic resection with patch application from February 2006 to September 2008 were included. At followup, all patients found to have a collection between the liver surface and the patch underwent a CT scan every three months.
  
  
  RESULTS
  Ten patients underwent hepatic resection with the patch application. No mortality occurred and the morbidity rate was 10%. No biliary leaks or free abdominal fluid collection occurred. At follow-up, fluid collections were detected in 60% of cases. The collected fluid did not increase in volume and in 66.6% of the cases the fluid spontaneously reabsorbed after a mean of 5.5 +/- 1.9 months from the operation.
  
  
  CONCLUSIONS
  The high incidence, lack of symptoms, favorable evolution and constant stability should be considered a display of patch tightness rather than a complication.
authors.affiliation: Department of Surgical Sciences, Organ Transplantation and Advanced Technologies, University of Catania, Cannizzaro Hospital, Catania, Italy. idicarlo@unict.it
authors.forename: Isidoro
authors.initials: I
authors.lastname: Di Carlo
authors.forename: Elia
authors.initials: E
authors.lastname: Pulvirenti
authors.forename: Adriana
authors.initials: A
authors.lastname: Toro
authors.forename: Annalisa
authors.initials: A
authors.lastname: Ardiri
authors.forename: Gaetano
authors.initials: G
authors.lastname: Bertino
mesh_terms: D000328:Adult; D000368:Aged; D001826:Body Fluids / Q000378:metabolism*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D005340:Fibrinogen / Q000008:administration & dosage; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011446:Prospective Studies; D013917:Thrombin / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed
chemical_list: D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D013917:Thrombin