title: N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation.
abstract: We synthesized a novel derivative of a well-known skin-lightening compound niacinamide, N-nicotinoyl dopamine (NND). NND did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. However, NND retains high antioxidant activity without affecting viability of cells. In a reconstructed skin model, topical applications of 0.05% and 0.1% NND induced skin lightening and decreased melanin production without affecting the viability and morphology of melanocytes and overall tissue histology. Moreover, no evidence for skin irritation or sensitization was observed when 0.1% NND emulsion was applied onto the skin of 52 volunteers. The effect of NND on skin lightening was further revealed by pigmented spot analyses of human clinical trial. Overall, NND treatment may be a useful trial for skin lightening and treating pigmentary disorders.
authors.affiliation: Enprani Co., Ltd., R&D Center of Skin Science and Cosmetics, Incheon, Korea.
authors.forename: Bora
authors.initials: B
authors.lastname: Kim
authors.forename: Jin Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Su Min
authors.initials: SM
authors.lastname: Lee
authors.forename: Soung-Hoon
authors.initials: SH
authors.lastname: Lee
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Myung Kyoo
authors.initials: MK
authors.lastname: Kim
authors.forename: Kye Jong
authors.initials: KJ
authors.lastname: Lee
authors.forename: Hyuk
authors.initials: H
authors.lastname: Kim
authors.forename: Joo Dong
authors.initials: JD
authors.lastname: Lee
authors.forename: Kang-Yell
authors.initials: KY
authors.lastname: Choi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D057886:Bleaching Agents / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy; D008546:Melanoma, Experimental; D051379:Mice; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D012880:Skin Pigmentation / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D057886:Bleaching Agents; D009536:Niacinamide; D004298:Dopamine; C000610699:N-nicotinoyl dopamine