title: IDO in human gut graft-versus-host disease.
abstract: Although rodent graft-versus-host disease (GVHD) models have suggested that indoleamine 2,3-dioxygenase (IDO) is a critical regulator of gastrointestinal GVHD, parallel human studies on IDO expression have not been reported. IDO expression was assessed in 20 patients who underwent duodenal biopsy. IDO was upregulated in epithelial cells. In situ analyses reveal that macrophages and dendritic cells stain positive for IDO, but that most of the IDO(+) cells were a novel population of CD3(+)CD4(+)IDO(+) cells. The proportion of CD4(+)IDO(+) T cells was significantly higher in patients with moderate GVHD. In situ regulatory T cell and Th17 numbers correlated with overall severity. Although needing confirmatory results from larger sample sets, these data are consistent with the hypothesis that IDO is involved in regulating gastrointestinal GVHD.
authors.affiliation: Inserm, U, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Ratajczak
authors.forename: Anne
authors.initials: A
authors.lastname: Janin
authors.forename: Régis
authors.initials: R
authors.lastname: Peffault de Larour
authors.forename: Lisa
authors.initials: L
authors.lastname: Koch
authors.forename: Brigitte
authors.initials: B
authors.lastname: Roche
authors.forename: David
authors.initials: D
authors.lastname: Munn
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Blazar
authors.forename: Gérard
authors.initials: G
authors.lastname: Socié
mesh_terms: D000328:Adult; D004386:Duodenum / Q000201:enzymology* / Q000276:immunology / Q000473:pathology; D004847:Epithelial Cells / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D005260:Female; D006086:Graft vs Host Disease / Q000201:enzymology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D058504:Th17 Cells / Q000201:enzymology / Q000276:immunology / Q000473:pathology
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase