title: Wound degradomics - current status and future perspectives.
abstract: Proteases are pivotal modulators of extracellular matrix components and bioactive proteins at all phases of cutaneous wound healing and thereby essentially contribute to the successful reestablishment of skin integrity upon injury. As a consequence, disturbance of proteolytic activity at the wound site is a major factor in the pathology of chronic wounds. A large body of data acquired in many years of research provide a good understanding of how individual proteases may influence the repair process. The next challenge will be to integrate these findings and to elucidate the complex interactions of proteolytic enzymes, their inhibitors and substrates on a system-wide level. Here, we present novel approaches that might help to achieve this ambitious goal in cutaneous wound healing research.
authors.affiliation: Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland.
authors.forename: Olivia
authors.initials: O
authors.lastname: Hermes
authors.forename: Pascal
authors.initials: P
authors.lastname: Schlage
authors.forename: Ulrich
authors.initials: U
authors.lastname: auf dem Keller
mesh_terms: D000818:Animals; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism*; D040901:Proteomics; D012867:Skin / Q000201:enzymology* / Q000378:metabolism; D014945:Wound Healing
chemical_list: D010447:Peptide Hydrolases