title: Random blood glucose measurement at antenatal booking to screen for overt diabetes in pregnancy: a retrospective study.
abstract: OBJECTIVE
  To assess random venous blood glucose (RBG) measurement at antenatal booking to detect "overt diabetes in pregnancy" (ODIP).
  
  
  METHODS
  A retrospective analysis of regional hospital obstetric data from 2004-2008 was performed. Universal RBG screening was included at booking. Oral glucose tolerance test (OGTT) was administered if RBG >7.0 mmol/L or other indications, e.g., if a 50-g glucose challenge test was >7.7 mmol/L at 26-28 weeks. ODIP was based upon World Health Organization plasma glucose criteria for diabetes.
  
  
  RESULTS
  RBG data were collected from 17,852/26,369 (67.7%) pregnancies around the initial antenatal visit; 3,007 women had an OGTT. The receiver operator curve area under the curve for RBG to detect ODIP was 0.86 (0.80-0.92) (assuming women without an OGTT did not have ODIP).
  
  
  CONCLUSIONS
  RBG at booking may provide a sufficiently sensitive screening tool for the detection of ODIP. We recommend further studies and comparison with fasting glucose and HbA(1c).
authors.affiliation: Department of Clinical Biochemistry, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK.
authors.forename: David
authors.initials: D
authors.lastname: Church
authors.forename: David
authors.initials: D
authors.lastname: Halsall
authors.forename: Claire
authors.initials: C
authors.lastname: Meek
authors.forename: Richard A
authors.initials: RA
authors.lastname: Parker
authors.forename: Helen R
authors.initials: HR
authors.lastname: Murphy
authors.forename: David
authors.initials: D
authors.lastname: Simmons
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001786:Blood Glucose